## Wed Oct 16 20:17:35 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/HKD1_bin.54.fa -m mmseqs --itype genome -o HKD1_bin.54 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/HKD1_bin.54 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1004362_1	644968.DFW101_2954	2.076e-09	58.0	COG3464@1|root,COG3464@2|Bacteria,1MV5J@1224|Proteobacteria,42M93@68525|delta/epsilon subdivisions,2WK5I@28221|Deltaproteobacteria,2M9GS@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Transposase, IS204 IS1001 IS1096 IS1165	-	-	-	ko:K07485	-	-	-	-	ko00000	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD1_k127_1004362_2	1121904.ARBP01000034_gene1830	1.225e-06	51.0	2BUNJ@1|root,32PZE@2|Bacteria,4NQFC@976|Bacteroidetes,47VU5@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1004362_0	1267535.KB906767_gene2663	3.188e-47	184.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Collagen,SprB,VPEP,fn3
HKD1_k127_1019236_2	1304885.AUEY01000002_gene359	4.714e-90	315.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MJRC@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_1019236_0	1267534.KB906760_gene1237	1.387e-235	742.0	COG0659@1|root,COG0659@2|Bacteria,3Y6R7@57723|Acidobacteria,2JM1A@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_1019236_1	1496688.ER33_02795	4.487e-144	462.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_1019236_4	1232410.KI421426_gene1483	5.086e-11	69.0	29WX2@1|root,30IJ3@2|Bacteria,1Q0W8@1224|Proteobacteria,433PA@68525|delta/epsilon subdivisions,2WXEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
HKD1_k127_1019236_3	671143.DAMO_0004	1e-63	225.0	COG0612@1|root,COG0612@2|Bacteria,2NPE5@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_1026835_16	671143.DAMO_2077	2.404e-28	113.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_1026835_18	316067.Geob_2631	8.691e-26	114.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria,43UWZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_1026835_4	335543.Sfum_2401	6.801e-127	432.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,PocR,Response_reg,dCache_1
HKD1_k127_1026835_19	1304885.AUEY01000021_gene3472	2.503e-25	115.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,42M4Y@68525|delta/epsilon subdivisions,2WKKD@28221|Deltaproteobacteria,2MIK0@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
HKD1_k127_1026835_9	485913.Krac_0147	9.018e-67	242.0	COG1482@1|root,COG1482@2|Bacteria	2|Bacteria	G	cell wall glycoprotein biosynthetic process	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HKD1_k127_1026835_22	1121899.Q764_03975	5.374e-07	55.0	COG1983@1|root,COG1983@2|Bacteria,4NG3T@976|Bacteroidetes,1HX01@117743|Flavobacteriia,2NT7H@237|Flavobacterium	976|Bacteroidetes	KT	Phage-shock protein	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	DUF2807,PspC
HKD1_k127_1026835_2	234267.Acid_3971	1.082e-165	535.0	COG1252@1|root,COG1252@2|Bacteria,3Y308@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_1026835_8	215803.DB30_8393	1.136e-74	265.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,42REB@68525|delta/epsilon subdivisions,2WNWD@28221|Deltaproteobacteria,2YUH8@29|Myxococcales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_1026835_21	671143.DAMO_2684	5.313e-14	75.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	mauD	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HKD1_k127_1026835_23	292459.STH1733	1.489e-06	54.0	COG0526@1|root,COG0526@2|Bacteria,1V7JP@1239|Firmicutes,25ET7@186801|Clostridia	186801|Clostridia	CO	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,Redoxin
HKD1_k127_1026835_14	1267535.KB906767_gene424	5.01e-31	127.0	COG0494@1|root,COG0494@2|Bacteria,3Y55X@57723|Acidobacteria	57723|Acidobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_1026835_10	671143.DAMO_2860	1.157e-66	236.0	COG1194@1|root,COG1194@2|Bacteria,2NPAU@2323|unclassified Bacteria	2|Bacteria	L	endonuclease III	mutY	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:1901360	2.1.1.37,2.1.3.15,6.4.1.2	ko:K00558,ko:K01962,ko:K01963,ko:K03575	ko00061,ko00270,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko03410,ko05206,map00061,map00270,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map03410,map05206	M00035,M00082,M00376	R00742,R04386,R04858	RC00003,RC00040,RC00253,RC00332,RC00367	ko00000,ko00001,ko00002,ko01000,ko02048,ko03032,ko03036,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD1_k127_1026835_13	314230.DSM3645_20247	2.189e-33	133.0	COG1359@1|root,COG1359@2|Bacteria,2J0XI@203682|Planctomycetes	203682|Planctomycetes	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_1026835_0	671143.DAMO_3171	7.499e-189	602.0	COG0277@1|root,COG0277@2|Bacteria,2NP2P@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1026835_5	671143.DAMO_3172	3.335e-118	399.0	COG0277@1|root,COG0277@2|Bacteria,2NP55@2323|unclassified Bacteria	2|Bacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1026835_1	671143.DAMO_3031	1.133e-170	546.0	COG0247@1|root,COG0247@2|Bacteria,2NNU8@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_17,Fer4_7,Fer4_8
HKD1_k127_1026835_11	247490.KSU1_B0249	8.685e-47	182.0	COG1192@1|root,COG1192@2|Bacteria,2IX5Z@203682|Planctomycetes	203682|Planctomycetes	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_1026835_6	263358.VAB18032_03290	5.621e-102	346.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DEDW@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_1026835_7	1499967.BAYZ01000060_gene6005	3.082e-76	262.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_1026835_3	861299.J421_6040	3.274e-159	514.0	COG0076@1|root,COG0076@2|Bacteria,1ZSZN@142182|Gemmatimonadetes	2|Bacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_1026835_12	266117.Rxyl_0901	6.454e-37	153.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2IH0Y@201174|Actinobacteria,4CU32@84995|Rubrobacteria	84995|Rubrobacteria	H	methylated-DNA- protein -cysteine S-methyltransferase	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1
HKD1_k127_1026835_17	1499968.TCA2_5107	5.074e-27	117.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,4HC17@91061|Bacilli,26TDT@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	sigW	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_1026835_15	1499967.BAYZ01000014_gene6363	2.133e-29	119.0	COG0111@1|root,COG0111@2|Bacteria,2NQWB@2323|unclassified Bacteria	2|Bacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iLJ478.TM0327	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_103605_0	439235.Dalk_5180	1.069e-178	567.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MIMJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_103605_1	439235.Dalk_5181	2.065e-60	215.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RMH@68525|delta/epsilon subdivisions,2WNKC@28221|Deltaproteobacteria,2MIZ2@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Electron transfer flavoprotein domain	etfB-3	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_1038432_1	977880.pRALTA_0023	3.957e-35	152.0	COG1752@1|root,COG1752@2|Bacteria	2|Bacteria	M	Esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_1038432_0	1238182.C882_1552	1.082e-117	396.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TQKV@28211|Alphaproteobacteria,2JPHX@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
HKD1_k127_1041383_2	56780.SYN_02954	8.819e-110	360.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,2MRHZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Fructose-bisphosphate aldolase class-II	fbaA	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_1041383_1	880072.Desac_2750	6.897e-206	649.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,2MQ9W@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_1041383_0	338966.Ppro_0419	0.0	1012.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,43U1C@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_1041459_0	485913.Krac_3419	7.396e-75	268.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
HKD1_k127_1041459_1	1040987.AZUY01000046_gene4415	2.608e-21	94.0	COG0286@1|root,COG0286@2|Bacteria	2|Bacteria	V	site-specific DNA-methyltransferase (adenine-specific) activity	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HKD1_k127_1044773_14	614083.AWQR01000025_gene3755	4.483e-38	147.0	COG0607@1|root,COG4275@1|root,COG0607@2|Bacteria,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VQ0S@28216|Betaproteobacteria,4ABCM@80864|Comamonadaceae	28216|Betaproteobacteria	P	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD1_k127_1044773_8	1501230.ET33_33920	5.66e-64	234.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,26QDE@186822|Paenibacillaceae	91061|Bacilli	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,MFS_3,Sugar_tr
HKD1_k127_1044773_5	1209989.TepiRe1_0147	1.552e-113	380.0	COG3875@1|root,COG3875@2|Bacteria,1UMTR@1239|Firmicutes,25GQI@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_1044773_10	555088.DealDRAFT_2812	7.509e-63	220.0	COG0693@1|root,COG0693@2|Bacteria,1V1CG@1239|Firmicutes,25CHN@186801|Clostridia	186801|Clostridia	S	TIGRFAM intracellular protease, PfpI family	pfpI	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_1044773_6	340099.Teth39_1970	5.384e-93	317.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia	186801|Clostridia	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_1044773_11	1380394.JADL01000011_gene3924	5.009e-58	213.0	COG3836@1|root,COG3836@2|Bacteria,1QY50@1224|Proteobacteria,2U2PU@28211|Alphaproteobacteria,2JVW5@204441|Rhodospirillales	204441|Rhodospirillales	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HKD1_k127_1044773_16	575540.Isop_1046	3.094e-27	117.0	COG1917@1|root,COG1917@2|Bacteria,2J134@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_1044773_4	1123242.JH636436_gene30	9.264e-115	384.0	COG2768@1|root,COG2768@2|Bacteria,2IXTH@203682|Planctomycetes	203682|Planctomycetes	C	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_1044773_12	1232410.KI421412_gene349	3.256e-56	206.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WPRF@28221|Deltaproteobacteria,43UU6@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Biotin/lipoate A/B protein ligase family	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
HKD1_k127_1044773_7	891968.Anamo_1259	3.736e-91	315.0	COG0508@1|root,COG0508@2|Bacteria,3TA12@508458|Synergistetes	508458|Synergistetes	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_1044773_2	1089553.Tph_c19640	2.294e-124	406.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,42F56@68295|Thermoanaerobacterales	186801|Clostridia	C	Transketolase, central region	-	-	1.2.4.4	ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_1044773_3	1089553.Tph_c19650	2.373e-120	394.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_1044773_15	653733.Selin_0116	2.117e-35	146.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K05799,ko:K07746	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	FCD,GntR
HKD1_k127_1044773_13	671143.DAMO_1685	2.168e-54	197.0	COG3945@1|root,COG4309@1|root,COG3945@2|Bacteria,COG4309@2|Bacteria,2NRHJ@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2249)	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	DUF2249,Hemerythrin
HKD1_k127_1044773_0	1254432.SCE1572_20065	0.0	1050.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD1_k127_1044773_9	1461579.CCNK01000011_gene290	1.455e-63	225.0	COG2846@1|root,COG2846@2|Bacteria,1MVCQ@1224|Proteobacteria,1RPY6@1236|Gammaproteobacteria,1Y9TT@135625|Pasteurellales	135625|Pasteurellales	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin
HKD1_k127_1044773_1	448385.sce3280	2.814e-180	578.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2X7TS@28221|Deltaproteobacteria,2YXZZ@29|Myxococcales	28221|Deltaproteobacteria	K	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	ko:K12266	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
HKD1_k127_1047301_5	1122919.KB905571_gene3064	1.544e-29	128.0	COG0395@1|root,COG0395@2|Bacteria,1UZIP@1239|Firmicutes,4HHYA@91061|Bacilli,26XRN@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_1047301_6	1499967.BAYZ01000067_gene6044	1.878e-23	107.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
HKD1_k127_1047301_8	1449065.JMLL01000012_gene3713	1.126e-12	72.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TQZY@28211|Alphaproteobacteria,43KJ7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_1047301_3	1033743.CAES01000002_gene1862	8.602e-39	162.0	COG1653@1|root,COG1653@2|Bacteria,1TQFZ@1239|Firmicutes,4HA0U@91061|Bacilli,26WHS@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_1047301_7	314256.OG2516_17840	9.126e-20	98.0	COG1802@1|root,COG1802@2|Bacteria,1RDIT@1224|Proteobacteria,2U7YZ@28211|Alphaproteobacteria,2PFP0@252301|Oceanicola	28211|Alphaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_1047301_4	404589.Anae109_2990	1.815e-31	137.0	COG2963@1|root,COG2963@2|Bacteria,1N1MP@1224|Proteobacteria,43BIX@68525|delta/epsilon subdivisions,2X6XD@28221|Deltaproteobacteria,2YVUT@29|Myxococcales	28221|Deltaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_Tnp_1
HKD1_k127_1047301_1	671143.DAMO_0401	9.138e-122	409.0	COG2801@1|root,COG2801@2|Bacteria,2NR9G@2323|unclassified Bacteria	2|Bacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve,rve_3
HKD1_k127_1047301_0	768671.ThimaDRAFT_1929	4.039e-190	607.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1WYPQ@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_1047301_2	379731.PST_0581	5.001e-88	300.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,1Z0CJ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	ISPsy14, transposition helper protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
HKD1_k127_1047301_9	311402.Avi_7693	1.28e-06	54.0	COG0789@1|root,COG1396@1|root,COG1917@1|root,COG0789@2|Bacteria,COG1396@2|Bacteria,COG1917@2|Bacteria,1RCRW@1224|Proteobacteria,2UBPH@28211|Alphaproteobacteria,4B7KU@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31,MerR_1
HKD1_k127_1049473_1	266117.Rxyl_0921	2.223e-106	350.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_1049473_3	1037409.BJ6T_66100	2.156e-30	126.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_15120	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_1049473_0	1100720.ALKN01000045_gene229	4.665e-195	621.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria,4AAW5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_1049473_4	204773.HEAR0351	2.997e-24	113.0	COG1102@1|root,COG2823@1|root,COG1102@2|Bacteria,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,2VK5B@28216|Betaproteobacteria,4760C@75682|Oxalobacteraceae	28216|Betaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
HKD1_k127_1049473_2	1134413.ANNK01000072_gene2863	5.631e-46	174.0	COG0800@1|root,COG0800@2|Bacteria,1TS0F@1239|Firmicutes,4HG4G@91061|Bacilli,1ZEB4@1386|Bacillus	91061|Bacilli	G	2-dehydro-3-deoxy-phosphogluconate aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HKD1_k127_1049473_5	391595.RLO149_c008600	5.031e-09	60.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2P4H9@2433|Roseobacter	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_1059101_40	1247726.MIM_c26180	2.518e-16	84.0	COG2188@1|root,COG2188@2|Bacteria,1MUEB@1224|Proteobacteria,2VNHN@28216|Betaproteobacteria,3T23A@506|Alcaligenaceae	28216|Betaproteobacteria	K	UTRA	-	-	-	ko:K03486,ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD1_k127_1059101_27	1122970.AUHC01000002_gene1264	3.781e-48	185.0	COG1222@1|root,COG1222@2|Bacteria,1QTV4@1224|Proteobacteria,2U0Q7@28211|Alphaproteobacteria,2K0N9@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the AAA ATPase family	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_1059101_29	880072.Desac_1765	6.042e-43	167.0	COG1247@1|root,COG1247@2|Bacteria,1R6UW@1224|Proteobacteria	1224|Proteobacteria	M	Acetyltransferase (GNAT) domain	MA20_16670	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_1059101_16	1499967.BAYZ01000078_gene982	1.954e-79	274.0	COG1801@1|root,COG1801@2|Bacteria,2NPDU@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_1059101_24	671143.DAMO_1713	3.575e-63	227.0	COG1678@1|root,COG1678@2|Bacteria	2|Bacteria	K	ribonucleoside-diphosphate reductase activity	MA20_18155	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD1_k127_1059101_13	1118054.CAGW01000033_gene4067	7.389e-95	332.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,26TTF@186822|Paenibacillaceae	91061|Bacilli	G	C4-dicarboxylate ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_1059101_39	457421.CBFG_01119	2.581e-19	99.0	COG3090@1|root,COG3090@2|Bacteria,1VAHP@1239|Firmicutes,24NMF@186801|Clostridia	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_1059101_25	1449126.JQKL01000002_gene1602	4.966e-55	206.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,269C3@186813|unclassified Clostridiales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_1059101_23	556261.HMPREF0240_00555	2.645e-64	234.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_1059101_34	1265505.ATUG01000001_gene3656	1.082e-31	128.0	COG1832@1|root,COG1832@2|Bacteria,1PUW7@1224|Proteobacteria,42T5D@68525|delta/epsilon subdivisions,2WPHZ@28221|Deltaproteobacteria,2MK69@213118|Desulfobacterales	28221|Deltaproteobacteria	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_1059101_45	472759.Nhal_1980	1.105e-07	59.0	2DD9Q@1|root,2ZH70@2|Bacteria,1P8P5@1224|Proteobacteria,1SWFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1059101_43	656519.Halsa_1404	5.747e-10	64.0	COG0757@1|root,COG0757@2|Bacteria,1V6E8@1239|Firmicutes,24JBK@186801|Clostridia,3WBRR@53433|Halanaerobiales	186801|Clostridia	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD1_k127_1059101_15	886293.Sinac_3494	4.396e-89	305.0	COG0500@1|root,COG4742@1|root,COG2226@2|Bacteria,COG4742@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_1059101_33	671143.DAMO_0367	6.776e-32	130.0	2C6B2@1|root,335GA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1059101_32	555779.Dthio_PD2840	1.063e-33	131.0	COG2929@1|root,COG2929@2|Bacteria,1N6QP@1224|Proteobacteria,42VMA@68525|delta/epsilon subdivisions,2WS3K@28221|Deltaproteobacteria,2ME5A@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnT_toxin
HKD1_k127_1059101_41	1047013.AQSP01000029_gene2172	3.319e-13	74.0	COG4914@1|root,COG4914@2|Bacteria,2NR4D@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
HKD1_k127_1059101_30	383372.Rcas_0089	8.044e-43	159.0	COG2361@1|root,COG2361@2|Bacteria,2G8W4@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HKD1_k127_1059101_37	395961.Cyan7425_3265	2.387e-24	105.0	COG1669@1|root,COG1669@2|Bacteria,1G8HY@1117|Cyanobacteria	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_1059101_26	913865.DOT_1899	2.163e-53	195.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,2612Y@186807|Peptococcaceae	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD1_k127_1059101_17	696369.KI912183_gene72	1.096e-78	275.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,261SM@186807|Peptococcaceae	186801|Clostridia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02525,ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_1,Peripla_BP_3
HKD1_k127_1059101_7	42256.RradSPS_3032	3.094e-123	430.0	COG1069@1|root,COG1069@2|Bacteria,2I41D@201174|Actinobacteria	201174|Actinobacteria	G	Belongs to the FGGY kinase family	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
HKD1_k127_1059101_0	309803.CTN_0381	3.627e-185	607.0	COG2407@1|root,COG2407@2|Bacteria,2GC41@200918|Thermotogae	200918|Thermotogae	G	L-fucose isomerase	-	-	5.3.1.25,5.3.1.3	ko:K01818	ko00051,ko01120,map00051,map01120	-	R03163	RC00434	ko00000,ko00001,ko01000	-	-	-	Fucose_iso_C,Fucose_iso_N1,Fucose_iso_N2
HKD1_k127_1059101_28	1150474.JQJI01000019_gene1460	3.155e-46	178.0	COG0329@1|root,COG0329@2|Bacteria,2GC68@200918|Thermotogae	200918|Thermotogae	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_1059101_6	1499967.BAYZ01000083_gene1028	2.264e-130	423.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_1059101_35	1499967.BAYZ01000083_gene1029	2.664e-27	118.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_1059101_2	1499967.BAYZ01000083_gene1030	1.534e-153	506.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_1059101_10	1411123.JQNH01000001_gene709	1.647e-102	350.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2U05K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,TAT_signal
HKD1_k127_1059101_12	1411123.JQNH01000001_gene709	1.624e-100	344.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2U05K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,TAT_signal
HKD1_k127_1059101_19	338969.Rfer_0953	8.727e-78	274.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VSSA@28216|Betaproteobacteria,4AEKS@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_1059101_14	649638.Trad_2184	1.102e-89	306.0	COG0395@1|root,COG0395@2|Bacteria,1WK7B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Carbohydrate ABC transporter membrane protein 2, CUT1 family	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_1059101_36	706587.Desti_4721	1.099e-25	108.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1059101_42	292459.STH685	4.357e-10	69.0	2EMGM@1|root,33F5A@2|Bacteria,1W2YC@1239|Firmicutes,256C3@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1059101_18	452637.Oter_4331	6.536e-78	268.0	COG1028@1|root,COG1028@2|Bacteria,46YNC@74201|Verrucomicrobia,3K7SX@414999|Opitutae	414999|Opitutae	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD1_k127_1059101_4	667632.KB890182_gene876	1.388e-140	464.0	COG1520@1|root,COG1520@2|Bacteria,1NDU1@1224|Proteobacteria,2WBCG@28216|Betaproteobacteria,1K4V0@119060|Burkholderiaceae	1224|Proteobacteria	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_3
HKD1_k127_1059101_5	706587.Desti_4719	5.5e-136	441.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD1_k127_1059101_3	706587.Desti_4720	7.071e-151	483.0	COG0003@1|root,COG0003@2|Bacteria,1MUTX@1224|Proteobacteria,42V9Y@68525|delta/epsilon subdivisions,2WND5@28221|Deltaproteobacteria,2MS8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Anion-transporting ATPase	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD1_k127_1059101_31	706587.Desti_4721	1.148e-36	141.0	2DZFA@1|root,32V98@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1059101_9	314230.DSM3645_15945	3.475e-104	351.0	COG1611@1|root,COG1611@2|Bacteria,2IXIR@203682|Planctomycetes	203682|Planctomycetes	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_1059101_21	671143.DAMO_2805	6.372e-73	256.0	COG1957@1|root,COG1957@2|Bacteria,2NPG1@2323|unclassified Bacteria	2|Bacteria	F	Inosine-uridine preferring nucleoside hydrolase	iunH	-	3.2.2.1	ko:K01239,ko:K01250	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HKD1_k127_1059101_20	330214.NIDE0494	1.21e-74	265.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	udgB	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033958,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
HKD1_k127_1059101_46	585394.RHOM_15060	1.602e-06	58.0	COG1700@1|root,COG1700@2|Bacteria,1TT3T@1239|Firmicutes,24DEW@186801|Clostridia	186801|Clostridia	S	PD-(D/E)XK nuclease superfamily	-	-	-	ko:K09124	-	-	-	-	ko00000	-	-	-	DUF2357,PDDEXK_7
HKD1_k127_1059101_8	1211115.ALIQ01000169_gene4026	1.025e-111	369.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TTFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_1059101_44	1411123.JQNH01000001_gene237	8.562e-10	66.0	2E6D9@1|root,3310W@2|Bacteria,1R35H@1224|Proteobacteria,2TZY3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_1059101_1	998674.ATTE01000001_gene1982	1.09e-173	559.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,1RMQB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Tripartite tricarboxylate transporter TctA	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD1_k127_1059101_22	247490.KSU1_C0891	5.566e-71	246.0	COG2110@1|root,COG2110@2|Bacteria,2IZUI@203682|Planctomycetes	203682|Planctomycetes	S	phosphatase homologous to the C-terminal domain of histone macroH2A1	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD1_k127_1059101_11	1499967.BAYZ01000185_gene4531	2.194e-102	340.0	COG0834@1|root,COG0834@2|Bacteria	2|Bacteria	ET	amino acid transport	pheC	-	4.2.1.51,4.2.1.91	ko:K01713,ko:K02030	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00236	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_1077488_4	1150469.RSPPHO_01690	7.257e-15	78.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,2JQ12@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_1077488_0	335543.Sfum_2287	3.472e-317	984.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MRC1@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_1077488_3	335543.Sfum_2286	2.875e-18	86.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
HKD1_k127_1077488_1	335543.Sfum_2285	8.831e-212	662.0	COG0683@1|root,COG0683@2|Bacteria,1RFC0@1224|Proteobacteria,42YW4@68525|delta/epsilon subdivisions,2WTXP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_1077488_2	1125863.JAFN01000001_gene1853	1.078e-21	95.0	COG0559@1|root,COG0559@2|Bacteria,1R23K@1224|Proteobacteria,42Z1D@68525|delta/epsilon subdivisions,2WU6V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_1083200_3	1499967.BAYZ01000182_gene4469	1.151e-194	621.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_1083200_24	670292.JH26_00885	0.0002029	53.0	2E6AZ@1|root,330YU@2|Bacteria,1N88X@1224|Proteobacteria,2UHAK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_1083200_8	1499967.BAYZ01000048_gene2683	1.493e-96	327.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_1083200_7	1123060.JONP01000001_gene1543	3.949e-97	336.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
HKD1_k127_1083200_18	1231190.NA8A_19288	2.663e-20	98.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_1083200_14	1209989.TepiRe1_1972	5.846e-56	210.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,24BWQ@186801|Clostridia,42H00@68295|Thermoanaerobacterales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_1083200_10	697281.Mahau_2710	2.834e-78	274.0	COG2855@1|root,COG2855@2|Bacteria,1TQYA@1239|Firmicutes,247X6@186801|Clostridia,42GM3@68295|Thermoanaerobacterales	186801|Clostridia	S	Conserved hypothetical protein 698	yeiH	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD1_k127_1083200_13	671143.DAMO_2574	1.219e-65	248.0	COG1427@1|root,COG1427@2|Bacteria,2NRPR@2323|unclassified Bacteria	2|Bacteria	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	1.21.98.1,4.2.1.151	ko:K07081,ko:K11782,ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588,R10666	RC02329,RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD1_k127_1083200_9	671143.DAMO_2575	3.969e-94	323.0	COG0402@1|root,COG0402@2|Bacteria,2NNT7@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	ssnA	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1083200_15	56780.SYN_00289	4.053e-41	159.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria,2MQKK@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Molybdopterin guanine dinucleotide synthesis protein B	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
HKD1_k127_1083200_19	671143.DAMO_2577	1.225e-19	95.0	COG1758@1|root,COG1758@2|Bacteria	2|Bacteria	K	DNA-directed 5'-3' RNA polymerase activity	rpoZ	GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030312,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0071944,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_1083200_12	671143.DAMO_2578	8.523e-68	246.0	COG0194@1|root,COG0194@2|Bacteria,2NPIN@2323|unclassified Bacteria	2|Bacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8,4.1.1.23	ko:K00942,ko:K01591	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00050,M00051	R00332,R00965,R02090	RC00002,RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2813,iIT341.HP0321,iPC815.YPO0040,iSBO_1134.SBO_3729,iSFV_1184.SFV_3881,iSFxv_1172.SFxv_4016,iUTI89_1310.UTI89_C4193	Guanylate_kin
HKD1_k127_1083200_11	671143.DAMO_2580	7.006e-74	261.0	COG1561@1|root,COG1561@2|Bacteria,2NPG5@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1732)	yicC	GO:0000175,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008408,GO:0009022,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_1083200_17	671143.DAMO_2572	1.725e-29	120.0	COG2331@1|root,COG2331@2|Bacteria,2NQ36@2323|unclassified Bacteria	2|Bacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_1083200_20	56780.SYN_03077	4.217e-19	97.0	COG5652@1|root,COG5652@2|Bacteria,1PUUC@1224|Proteobacteria,43F3B@68525|delta/epsilon subdivisions,2X381@28221|Deltaproteobacteria,2MSC7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD1_k127_1083200_1	671143.DAMO_2469	4.45e-248	778.0	COG0442@1|root,COG0442@2|Bacteria,2NNNH@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD1_k127_1083200_4	671143.DAMO_2468	4.822e-148	492.0	COG0821@1|root,COG0821@2|Bacteria,2NNPV@2323|unclassified Bacteria	2|Bacteria	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006081,GO:0006082,GO:0006090,GO:0006091,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009055,GO:0009058,GO:0009240,GO:0009987,GO:0016020,GO:0016491,GO:0016725,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0022900,GO:0030312,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044464,GO:0046429,GO:0046490,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0052592,GO:0055114,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901576	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430,iJN678.gcpE	GcpE
HKD1_k127_1083200_6	671143.DAMO_2467	4.478e-111	375.0	COG0750@1|root,COG0750@2|Bacteria,2NP7C@2323|unclassified Bacteria	2|Bacteria	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD1_k127_1083200_5	667014.Thein_2089	8.661e-123	407.0	COG0743@1|root,COG0743@2|Bacteria,2GHA5@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD1_k127_1083200_22	671143.DAMO_2462	2.999e-14	77.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K12065,ko:K13052	-	-	-	-	ko00000,ko02044,ko03036	3.A.7.11.1	-	-	DivIC
HKD1_k127_1083200_2	443143.GM18_3499	3.998e-195	618.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,42MS9@68525|delta/epsilon subdivisions,2WJMS@28221|Deltaproteobacteria,43U3Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_1083200_0	671143.DAMO_2460	0.0	1135.0	COG1109@1|root,COG1208@1|root,COG1109@2|Bacteria,COG1208@2|Bacteria,2NQFC@2323|unclassified Bacteria	2|Bacteria	GJM	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	mpg	-	1.6.5.5,2.7.7.13,5.4.2.10,5.4.2.2,5.4.2.8	ko:K00344,ko:K00966,ko:K01840,ko:K03431,ko:K15778,ko:K16881	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00361,M00362	R00885,R00959,R01057,R01818,R02060,R08639	RC00002,RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3178	Hexapep,NTP_transferase,PGM_PMM_I,PGM_PMM_II,PGM_PMM_III
HKD1_k127_1083200_16	933262.AXAM01000172_gene934	3.206e-33	130.0	COG2337@1|root,COG2337@2|Bacteria,1N1DE@1224|Proteobacteria,42WAI@68525|delta/epsilon subdivisions,2WRAJ@28221|Deltaproteobacteria,2MNJZ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_1083200_21	589865.DaAHT2_0744	9.904e-17	81.0	COG0864@1|root,COG0864@2|Bacteria,1N84E@1224|Proteobacteria,42VWB@68525|delta/epsilon subdivisions,2WRHU@28221|Deltaproteobacteria,2MNZW@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD1_k127_1083200_23	1123242.JH636435_gene2133	5.12e-11	65.0	COG2055@1|root,COG2055@2|Bacteria,2IZK5@203682|Planctomycetes	203682|Planctomycetes	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_1084799_8	1267533.KB906745_gene60	1.552e-47	171.0	COG0166@1|root,COG0166@2|Bacteria,3Y3HG@57723|Acidobacteria,2JIQE@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the GPI family	-	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_1084799_5	1382306.JNIM01000001_gene770	6.489e-73	252.0	COG0036@1|root,COG0036@2|Bacteria,2G6EU@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_1084799_1	886293.Sinac_0946	3.089e-169	537.0	COG1023@1|root,COG1023@2|Bacteria,2IYCD@203682|Planctomycetes	203682|Planctomycetes	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD1_k127_1084799_4	404589.Anae109_0599	2.928e-82	279.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase	pgl	-	2.7.1.12,3.1.1.31	ko:K00851,ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R01737,R02035	RC00002,RC00017,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD1_k127_1084799_6	1463858.JOHR01000004_gene1742	8.936e-62	222.0	28HIR@1|root,2Z7U4@2|Bacteria,2GN2S@201174|Actinobacteria	201174|Actinobacteria	S	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_1084799_0	383372.Rcas_3080	0.0	1025.0	COG1053@1|root,COG1053@2|Bacteria,2G5YB@200795|Chloroflexi,374WX@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_1084799_2	383372.Rcas_3081	8.705e-115	376.0	COG0479@1|root,COG0479@2|Bacteria,2GACG@200795|Chloroflexi,3758X@32061|Chloroflexia	32061|Chloroflexia	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD1_k127_1084799_7	1040989.AWZU01000002_gene5221	3.785e-59	212.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3JQPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_1084799_11	929556.Solca_1806	3.75e-22	105.0	2E3RZ@1|root,32YPK@2|Bacteria,4NVPS@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084799_12	1232410.KI421426_gene1467	3.958e-22	102.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria	1224|Proteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
HKD1_k127_1084799_9	1244869.H261_17453	2.109e-38	167.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TRHH@28211|Alphaproteobacteria,2JPVE@204441|Rhodospirillales	204441|Rhodospirillales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07716	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HKD1_k127_1084799_3	1396141.BATP01000002_gene4798	4.732e-90	333.0	COG4191@1|root,COG4191@2|Bacteria,46ZJR@74201|Verrucomicrobia,2IV4D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD1_k127_1084799_13	247490.KSU1_D1022	5.811e-10	60.0	COG1724@1|root,COG1724@2|Bacteria,2J4RJ@203682|Planctomycetes	203682|Planctomycetes	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084799_10	391612.CY0110_26712	4.942e-29	117.0	COG1598@1|root,COG1598@2|Bacteria,1G9MA@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_1098227_4	1286093.C266_24533	7.34e-35	139.0	COG0526@1|root,COG0526@2|Bacteria,1RDGI@1224|Proteobacteria,2VT2S@28216|Betaproteobacteria,1K3AC@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_1098227_0	1117379.BABA_23183	2.138e-129	429.0	COG0620@1|root,COG0620@2|Bacteria,1TP2H@1239|Firmicutes,4H9QC@91061|Bacilli,1ZBI7@1386|Bacillus	91061|Bacilli	E	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HKD1_k127_1098227_1	1117379.BABA_23188	2.452e-60	220.0	COG0425@1|root,COG1765@1|root,COG0425@2|Bacteria,COG1765@2|Bacteria,1U9IG@1239|Firmicutes,4IJP4@91061|Bacilli,1ZCSK@1386|Bacillus	91061|Bacilli	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	OsmC,TusA
HKD1_k127_1098227_2	1212548.B381_18249	3.518e-54	193.0	COG2044@1|root,COG2044@2|Bacteria,1N4KA@1224|Proteobacteria,1SC3W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD1_k127_1098227_5	1123507.ATVQ01000003_gene618	1.058e-15	85.0	2BMJ7@1|root,32G45@2|Bacteria,2H1DR@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HKD1_k127_1098227_3	883110.HMPREF9260_00970	8.583e-39	160.0	COG1305@1|root,COG1305@2|Bacteria,1TT33@1239|Firmicutes	1239|Firmicutes	E	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_1098227_6	644282.Deba_1724	1.189e-12	70.0	COG0582@1|root,COG0582@2|Bacteria,1MVZB@1224|Proteobacteria,42W21@68525|delta/epsilon subdivisions,2WRE7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
HKD1_k127_1123002_1	1408473.JHXO01000001_gene2146	4.566e-75	262.0	COG1453@1|root,COG1453@2|Bacteria,4NJU2@976|Bacteroidetes,2G2UD@200643|Bacteroidia	976|Bacteroidetes	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD1_k127_1123002_3	1168289.AJKI01000011_gene481	1.127e-48	185.0	2CK1R@1|root,32V4M@2|Bacteria,4NTYZ@976|Bacteroidetes,2FU5M@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1123002_7	1380355.JNIJ01000046_gene1355	2.707e-11	70.0	2EFUW@1|root,339M2@2|Bacteria,1R8JP@1224|Proteobacteria,2U5Q7@28211|Alphaproteobacteria,3JYA2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_23140	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_1123002_0	706587.Desti_3265	1.52e-205	650.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_1123002_2	1268622.AVS7_02240	3.831e-66	238.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2VHK8@28216|Betaproteobacteria,4A9R8@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_1123002_6	314230.DSM3645_05830	1.303e-31	134.0	COG1082@1|root,COG1082@2|Bacteria,2IYUT@203682|Planctomycetes	203682|Planctomycetes	G	PFAM Xylose isomerase	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_1123002_8	410358.Mlab_0427	5.478e-06	59.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_1123002_5	880072.Desac_0462	4.221e-34	140.0	COG1402@1|root,COG1402@2|Bacteria,1MXR9@1224|Proteobacteria,42QNA@68525|delta/epsilon subdivisions,2WIN0@28221|Deltaproteobacteria,2MRIE@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_1123002_4	368408.Tpen_1553	3.267e-44	167.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPVK@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran
HKD1_k127_1134650_1	1123504.JQKD01000101_gene3532	1.683e-16	87.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2VPAP@28216|Betaproteobacteria,4AFM7@80864|Comamonadaceae	28216|Betaproteobacteria	L	Insertion element 4 transposase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Nterm_IS4
HKD1_k127_1134650_2	1170562.Cal6303_2855	2.285e-12	80.0	COG1609@1|root,COG1609@2|Bacteria,1G54D@1117|Cyanobacteria,1HMP3@1161|Nostocales	1117|Cyanobacteria	K	PFAM Rhodopirellula transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_1134650_0	383372.Rcas_0928	2.19e-129	432.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_1137029_0	335543.Sfum_3024	2.759e-140	449.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2MQ8Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Thiamine pyrophosphate enzyme, central	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_1137029_1	335543.Sfum_1786	1.632e-52	193.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,42RIT@68525|delta/epsilon subdivisions,2WP64@28221|Deltaproteobacteria,2MQKS@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Glycoprotease family	yeaZ	-	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_1137307_3	1499967.BAYZ01000156_gene565	6.624e-134	435.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_1137307_2	1449126.JQKL01000013_gene3410	6.682e-155	501.0	COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia,2682H@186813|unclassified Clostridiales	186801|Clostridia	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	-	-	4.2.1.7	ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
HKD1_k127_1137307_4	1121904.ARBP01000001_gene5773	3.506e-100	346.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	larA	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
HKD1_k127_1137307_1	941449.dsx2_0707	4.877e-197	627.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,42KZU@68525|delta/epsilon subdivisions,2WJ6T@28221|Deltaproteobacteria,2M7RJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD1_k127_1137307_5	1382359.JIAL01000001_gene1816	3.56e-74	265.0	COG1566@1|root,COG1566@2|Bacteria,3Y2GY@57723|Acidobacteria,2JIUM@204432|Acidobacteriia	204432|Acidobacteriia	V	Biotin-lipoyl like	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_1137307_7	1120983.KB894576_gene3397	2.571e-27	120.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,1JP6K@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
HKD1_k127_1137307_6	75379.Tint_0420	1.113e-65	230.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ6F@28216|Betaproteobacteria,1KKPY@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_1137307_0	641491.DND132_0693	2.389e-246	784.0	COG0457@1|root,COG0457@2|Bacteria,1MX2U@1224|Proteobacteria,42QJC@68525|delta/epsilon subdivisions,2WPI2@28221|Deltaproteobacteria,2M9VY@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,HEAT_2,Paired_CXXCH_1,TPR_10,TPR_16,TPR_19,TPR_4,TPR_8
HKD1_k127_1140320_0	502025.Hoch_1145	2.932e-23	113.0	COG3385@1|root,COG3385@2|Bacteria,1NBHF@1224|Proteobacteria,43BBP@68525|delta/epsilon subdivisions,2WRX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD1_k127_1156973_3	1499967.BAYZ01000068_gene1935	5.049e-08	54.0	COG3266@1|root,COG3420@1|root,COG4733@1|root,COG3266@2|Bacteria,COG3420@2|Bacteria,COG4733@2|Bacteria,2NS5M@2323|unclassified Bacteria	2|Bacteria	P	Fibronectin type 3 domain	-	-	-	ko:K12685,ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000,ko02044	1.B.12.5.1,1.B.12.5.3,3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CHB_HEX_C_1,CHU_C,DUF1573,DUF285,F5_F8_type_C,Laminin_G_3,Lectin_legB,fn3
HKD1_k127_1156973_1	251221.35213780	4.954e-47	177.0	COG4293@1|root,COG4293@2|Bacteria,1G555@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG4293 conserved	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
HKD1_k127_1156973_2	4113.PGSC0003DMT400001249	3.686e-28	119.0	COG2138@1|root,2RXIW@2759|Eukaryota,37TYY@33090|Viridiplantae,3GHWI@35493|Streptophyta,44HX7@71274|asterids	35493|Streptophyta	S	CbiX	-	GO:0003674,GO:0003824,GO:0004325,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009058,GO:0009507,GO:0009536,GO:0009987,GO:0016829,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046156,GO:0046483,GO:0048037,GO:0050896,GO:0051186,GO:0051188,GO:0051266,GO:0051536,GO:0051540,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.4	ko:K03794	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R02864	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiX
HKD1_k127_1156973_0	1121121.KB894290_gene1888	3.157e-49	180.0	COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,4HRFR@91061|Bacilli,2753A@186822|Paenibacillaceae	91061|Bacilli	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_1156973_4	293227.XP_008716631.1	6.612e-05	46.0	COG0175@1|root,KOG2644@2759|Eukaryota,39U3G@33154|Opisthokonta,3NXB1@4751|Fungi,3QQBV@4890|Ascomycota,20C9V@147545|Eurotiomycetes,3MVZ2@451870|Chaetothyriomycetidae	4751|Fungi	EH	Probable molybdopterin binding domain	-	GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0008150,GO:0008152,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044464,GO:0055114	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_117831_2	1458357.BG58_28305	2.965e-59	231.0	COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,2WI17@28216|Betaproteobacteria,1KG8X@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_117831_1	338966.Ppro_0408	8.358e-112	374.0	29MQ2@1|root,308MT@2|Bacteria,1REUR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_117831_4	314278.NB231_07442	4.329e-36	144.0	2E3RZ@1|root,32YPK@2|Bacteria,1NJYT@1224|Proteobacteria,1SHP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_117831_3	1118235.CAJH01000033_gene2155	1.302e-51	189.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(twin-arginine translocation) pathway signal	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_117831_0	1449065.JMLL01000012_gene3738	2.27e-160	509.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2U1RU@28211|Alphaproteobacteria,43MQW@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Predicted Permease Membrane Region	-	-	-	-	-	-	-	-	-	-	-	-	Asp-Al_Ex,TrkA_C
HKD1_k127_1182715_18	1007096.BAGW01000017_gene883	8.355e-29	119.0	COG1694@1|root,COG1694@2|Bacteria,1VA3E@1239|Firmicutes,24NYY@186801|Clostridia,2N7AY@216572|Oscillospiraceae	186801|Clostridia	S	MazG-like family	-	-	-	-	-	-	-	-	-	-	-	-	MazG-like
HKD1_k127_1182715_24	485913.Krac_4174	7.026e-14	82.0	29XJU@1|root,30JAW@2|Bacteria,2G9DS@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_6	1009370.ALO_11459	1.597e-121	398.0	COG1063@1|root,COG1063@2|Bacteria,1U91N@1239|Firmicutes,4H8ZE@909932|Negativicutes	909932|Negativicutes	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1182715_3	266117.Rxyl_0923	3.58e-191	603.0	COG0075@1|root,COG0075@2|Bacteria,2GM5F@201174|Actinobacteria,4CQFE@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase, class V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_1182715_0	94624.Bpet4353	4.569e-251	781.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_1182715_13	94624.Bpet4352	1.291e-61	218.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_1182715_5	94624.Bpet4351	6.707e-134	436.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VKSV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_1182715_11	401526.TcarDRAFT_2289	9.644e-66	230.0	2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,4H7KF@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_8	1009370.ALO_01424	4.552e-80	277.0	COG1145@1|root,COG1145@2|Bacteria,1UIDU@1239|Firmicutes,4H7FN@909932|Negativicutes	909932|Negativicutes	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_9	264732.Moth_0724	1.027e-79	282.0	COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,24AD5@186801|Clostridia,42FHR@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_1182715_21	1121422.AUMW01000028_gene3413	6.409e-19	101.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,25ZZF@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD1_k127_1182715_16	635013.TherJR_1938	1.564e-39	154.0	COG1142@1|root,COG1142@2|Bacteria,1V809@1239|Firmicutes,25E9V@186801|Clostridia,262AX@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S	-	-	-	ko:K00196	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	-	R07157,R08034	RC00250,RC02800	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4
HKD1_k127_1182715_15	696369.KI912183_gene2503	1.297e-48	181.0	2AV93@1|root,31M00@2|Bacteria,1V94N@1239|Firmicutes,251VU@186801|Clostridia,265SD@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_14	138119.DSY0993	8.726e-56	204.0	COG1145@1|root,COG1145@2|Bacteria,1UIDU@1239|Firmicutes,25EIV@186801|Clostridia,267A7@186807|Peptococcaceae	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_7	1293048.CBMB010000006_gene3059	2.19e-88	303.0	COG2309@1|root,arCOG01890@2157|Archaea,2XVX8@28890|Euryarchaeota,23UIJ@183963|Halobacteria	183963|Halobacteria	E	Leucyl aminopeptidase (Aminopeptidase t)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_4	706587.Desti_3265	3.465e-167	539.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_1182715_23	479434.Sthe_3001	9.219e-15	80.0	2DSW1@1|root,33HMW@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_1182715_10	644966.Tmar_1750	3.892e-68	249.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,24MEW@186801|Clostridia	186801|Clostridia	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD1_k127_1182715_2	639283.Snov_1607	1.967e-210	677.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,3EZS5@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_1182715_17	1304880.JAGB01000002_gene1925	7.387e-34	140.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24E6I@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_1182715_25	1401065.HMPREF2130_11430	1.868e-05	49.0	COG2409@1|root,COG2409@2|Bacteria,1NRRD@1224|Proteobacteria	1224|Proteobacteria	S	Drug exporters of the RND superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_19	478741.JAFS01000002_gene81	5.632e-25	105.0	2CAAC@1|root,34561@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1182715_20	41431.PCC8801_1300	2.768e-24	120.0	COG0457@1|root,COG0457@2|Bacteria,1GIT8@1117|Cyanobacteria,3KHZU@43988|Cyanothece	1117|Cyanobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8,Trypsin_2
HKD1_k127_1182715_12	983917.RGE_08880	2.41e-65	240.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2WI85@28216|Betaproteobacteria,1KPDS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Vacuole effluxer Atg22 like	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_1182715_1	1341151.ASZU01000031_gene2730	2.422e-250	784.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,4H9ZG@91061|Bacilli,27BIC@186824|Thermoactinomycetaceae	91061|Bacilli	EG	Dehydratase family	ilvD	-	4.2.1.9	ko:K01687,ko:K16786	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,ko02010,map00290,map00770,map01100,map01110,map01130,map01210,map01230,map02010	M00019,M00570,M00582	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ILVD_EDD
HKD1_k127_1182715_22	1472418.BBJC01000005_gene2278	9.428e-16	78.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TTNG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_43565	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_1223524_1	298655.KI912266_gene4860	2.335e-87	298.0	COG2055@1|root,COG2055@2|Bacteria,2GN93@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
HKD1_k127_1223524_2	935261.JAGL01000043_gene2123	4.953e-46	169.0	COG1487@1|root,COG1487@2|Bacteria,1RJ2J@1224|Proteobacteria,2UA97@28211|Alphaproteobacteria,43K0H@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_1223524_4	323261.Noc_2538	4.537e-23	104.0	COG2002@1|root,COG2002@2|Bacteria,1NKXK@1224|Proteobacteria,1SRBJ@1236|Gammaproteobacteria,1X1W0@135613|Chromatiales	135613|Chromatiales	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD1_k127_1223524_3	671143.DAMO_1180	1.99e-24	105.0	COG3177@1|root,COG3177@2|Bacteria,2NREB@2323|unclassified Bacteria	2|Bacteria	S	Filamentation induced by cAMP protein fic	fic	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD1_k127_1223524_0	631362.Thi970DRAFT_02641	6.201e-153	486.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,1RMRA@1236|Gammaproteobacteria,1WX0S@135613|Chromatiales	135613|Chromatiales	V	PFAM N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
HKD1_k127_1228245_0	243231.GSU2782	0.0	1491.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_1234553_2	671143.DAMO_0750	7.352e-187	591.0	COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria	2|Bacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_1234553_0	671143.DAMO_0749	1.46e-255	802.0	COG1222@1|root,COG2433@1|root,COG1222@2|Bacteria,COG2433@2|Bacteria,2NQB9@2323|unclassified Bacteria	2|Bacteria	O	Proteasomal ATPase OB/ID domain	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	2.7.13.3	ko:K07184,ko:K07777,ko:K12065,ko:K13525,ko:K13527	ko02020,ko03050,ko04141,ko05134,map02020,map03050,map04141,map05134	M00342,M00400,M00403,M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02044,ko03019,ko03051,ko04131,ko04147	3.A.16.1,3.A.7.11.1	-	-	AAA,Prot_ATP_ID_OB
HKD1_k127_1234553_16	671143.DAMO_0689	4.836e-14	73.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_1234553_15	671143.DAMO_0690	1.106e-14	76.0	2E9C2@1|root,30ZT9@2|Bacteria,2NRQ4@2323|unclassified Bacteria	2|Bacteria	S	Pup-like protein	-	-	-	ko:K13570	-	-	-	-	ko00000,ko04121	-	-	-	Pup
HKD1_k127_1234553_10	671143.DAMO_0691	4.873e-51	193.0	COG0521@1|root,COG0521@2|Bacteria,2NR7Z@2323|unclassified Bacteria	2|Bacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HKD1_k127_1234553_8	1125863.JAFN01000001_gene1846	2.985e-64	228.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,42QWD@68525|delta/epsilon subdivisions,2WN14@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	beta-lactamase domain protein	ycbL	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_1234553_5	1382356.JQMP01000003_gene1909	1.284e-91	309.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia	189775|Thermomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD1_k127_1234553_6	671143.DAMO_0692	4.255e-74	264.0	COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c	GTP_cyclohydroI
HKD1_k127_1234553_13	379066.GAU_0779	6.781e-31	126.0	COG0720@1|root,COG0720@2|Bacteria,1ZTV2@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_1234553_12	518766.Rmar_0192	2.076e-32	130.0	COG0720@1|root,COG0720@2|Bacteria,4NNY0@976|Bacteroidetes,1FJAI@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_1234553_7	1128421.JAGA01000002_gene944	9.716e-72	259.0	COG0438@1|root,COG0438@2|Bacteria,2NR08@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_1234553_11	1232410.KI421426_gene1402	1.956e-40	156.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,42TAG@68525|delta/epsilon subdivisions,2WPRH@28221|Deltaproteobacteria,43SJK@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_1234553_14	671143.DAMO_1405	6.411e-29	127.0	COG5426@1|root,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1234553_4	1121468.AUBR01000039_gene1946	1.69e-100	345.0	COG4198@1|root,COG4198@2|Bacteria,1TQSW@1239|Firmicutes,249E4@186801|Clostridia,42F45@68295|Thermoanaerobacterales	186801|Clostridia	S	conserved protein UCP033563	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD1_k127_1234553_1	1321778.HMPREF1982_04262	9.945e-219	684.0	COG0205@1|root,COG0205@2|Bacteria,1TRJQ@1239|Firmicutes,247IV@186801|Clostridia,2688K@186813|unclassified Clostridiales	186801|Clostridia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_1234553_3	1499967.BAYZ01000068_gene1948	1.177e-118	399.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1234553_9	530564.Psta_2957	8.64e-60	214.0	COG2055@1|root,COG2055@2|Bacteria,2IWXD@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	ko:K13574	-	-	-	-	ko00000,ko01000	-	-	-	Ldh_2
HKD1_k127_1265550_3	1499967.BAYZ01000185_gene4523	7.673e-108	357.0	COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria	2|Bacteria	S	Amidohydrolase family	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_1265550_2	1499967.BAYZ01000185_gene4524	2.949e-122	413.0	COG1173@1|root,COG1173@2|Bacteria	2|Bacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_1265550_1	1499967.BAYZ01000185_gene4525	2.458e-132	428.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_1265550_0	1499967.BAYZ01000185_gene4526	1.95e-216	684.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_1266046_3	596152.DesU5LDRAFT_3930	3.193e-07	53.0	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42VSP@68525|delta/epsilon subdivisions,2WRGT@28221|Deltaproteobacteria,2MCUX@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM regulatory protein ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_1266046_0	194439.CT1717	1.846e-100	330.0	COG2191@1|root,COG2191@2|Bacteria	2|Bacteria	C	Formylmethanofuran dehydrogenase, subunit e	-	-	1.2.7.12	ko:K11261	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	FmdE,zf-dskA_traR
HKD1_k127_1266046_1	118166.JH976537_gene1044	8.81e-60	224.0	COG2059@1|root,COG2059@2|Bacteria,1G37Z@1117|Cyanobacteria,1HA7A@1150|Oscillatoriales	1117|Cyanobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_1266046_2	266117.Rxyl_0898	2.893e-51	194.0	COG1725@1|root,COG1725@2|Bacteria,2I4BB@201174|Actinobacteria,4CTS5@84995|Rubrobacteria	84995|Rubrobacteria	K	regulatory protein, gntR	-	-	-	-	-	-	-	-	-	-	-	-	GntR
HKD1_k127_1285233_19	717605.Theco_3395	5.521e-28	132.0	COG2931@1|root,COG2931@2|Bacteria,1V022@1239|Firmicutes,4HFJ6@91061|Bacilli,26SF3@186822|Paenibacillaceae	91061|Bacilli	Q	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD1_k127_1285233_22	247490.KSU1_A0008	2.317e-13	84.0	COG4447@1|root,COG5492@1|root,COG4447@2|Bacteria,COG5492@2|Bacteria,2J3BX@203682|Planctomycetes	203682|Planctomycetes	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1285233_0	671143.DAMO_1433	6.168e-189	598.0	COG0304@1|root,COG0304@2|Bacteria,2NNSX@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0033817,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1095,iAPECO1_1312.APECO1_176,iB21_1397.B21_01099,iBWG_1329.BWG_0943,iE2348C_1286.E2348C_1187,iEC042_1314.EC042_1165,iEC55989_1330.EC55989_1207,iECABU_c1320.ECABU_c13085,iECBD_1354.ECBD_2506,iECB_1328.ECB_01091,iECDH10B_1368.ECDH10B_1167,iECDH1ME8569_1439.ECDH1ME8569_1030,iECD_1391.ECD_01091,iECED1_1282.ECED1_1238,iECH74115_1262.ECH74115_1474,iECIAI1_1343.ECIAI1_1130,iECIAI39_1322.ECIAI39_2066,iECO103_1326.ECO103_1140,iECO111_1330.ECO111_1372,iECO26_1355.ECO26_1428,iECOK1_1307.ECOK1_1202,iECP_1309.ECP_1087,iECS88_1305.ECS88_1109,iECSE_1348.ECSE_1159,iECSF_1327.ECSF_0994,iECSP_1301.ECSP_1396,iECUMN_1333.ECUMN_1270,iECW_1372.ECW_m1203,iECs_1301.ECs1473,iEKO11_1354.EKO11_2739,iETEC_1333.ETEC_1160,iEcDH1_1363.EcDH1_2552,iEcE24377_1341.EcE24377A_1216,iEcSMS35_1347.EcSMS35_2032,iG2583_1286.G2583_1355,iJO1366.b1095,iJR904.b1095,iLF82_1304.LF82_0607,iNRG857_1313.NRG857_05280,iSF_1195.SF1099,iSFxv_1172.SFxv_1251,iS_1188.S1179,iUMN146_1321.UM146_11850,iWFL_1372.ECW_m1203,iY75_1357.Y75_RS05720,iZ_1308.Z1734,ic_1306.c1365	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_1285233_18	1499967.BAYZ01000055_gene4865	1.43e-29	120.0	COG0236@1|root,COG0236@2|Bacteria,2NPVJ@2323|unclassified Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_1285233_11	1280390.CBQR020000018_gene391	1.237e-74	258.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,26QK6@186822|Paenibacillaceae	91061|Bacilli	IQ	reductase	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
HKD1_k127_1285233_10	243231.GSU1602	5.301e-95	320.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,43UBD@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD1_k127_1285233_6	671143.DAMO_1437	7.468e-130	422.0	COG0332@1|root,COG0332@2|Bacteria,2NNX5@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_1285233_4	671143.DAMO_1438	4.529e-133	432.0	COG0416@1|root,COG0416@2|Bacteria,2NP1H@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.21.4.2,1.21.4.3,1.21.4.4,2.3.1.15	ko:K03621,ko:K21576,ko:K21577	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD1_k127_1285233_20	1382359.JIAL01000001_gene525	1.733e-19	89.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_1285233_16	671143.DAMO_1440	5.975e-39	151.0	COG1399@1|root,COG1399@2|Bacteria,2NQ7G@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterized ACR, COG1399	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD1_k127_1285233_13	671143.DAMO_1441	1.547e-49	180.0	COG0105@1|root,COG0105@2|Bacteria,2NPM5@2323|unclassified Bacteria	2|Bacteria	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_1285233_5	671143.DAMO_1442	2.255e-132	430.0	COG0074@1|root,COG0074@2|Bacteria,2NNZD@2323|unclassified Bacteria	2|Bacteria	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	GO:0001539,GO:0003674,GO:0003824,GO:0004774,GO:0004776,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006928,GO:0008150,GO:0008152,GO:0009361,GO:0009987,GO:0016310,GO:0016874,GO:0016877,GO:0016878,GO:0019538,GO:0031974,GO:0032991,GO:0036211,GO:0040011,GO:0042709,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0045239,GO:0046777,GO:0048870,GO:0051179,GO:0051674,GO:0070013,GO:0071704,GO:0071973,GO:0097588,GO:1901564,GO:1902494	6.2.1.5	ko:K01902,ko:K02381	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_0608,iYO844.BSU16100	CoA_binding,DUF1116,Ligase_CoA
HKD1_k127_1285233_2	671143.DAMO_1443	3.285e-161	518.0	COG0045@1|root,COG0045@2|Bacteria,2NNQA@2323|unclassified Bacteria	2|Bacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_1285233_7	1242864.D187_007613	2.138e-122	399.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,2YVVI@29|Myxococcales	28221|Deltaproteobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_1285233_21	198467.NP92_13165	3.245e-14	86.0	COG1233@1|root,COG1233@2|Bacteria,1UU71@1239|Firmicutes,4HA25@91061|Bacilli,21WXH@150247|Anoxybacillus	91061|Bacilli	Q	Flavin containing amine oxidoreductase	-	-	5.2.1.13	ko:K09835	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R07512	RC01960	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD1_k127_1285233_3	1121468.AUBR01000051_gene2000	7.744e-145	471.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,42F2X@68295|Thermoanaerobacterales	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD1_k127_1285233_25	1211814.CAPG01000019_gene573	7.937e-09	66.0	28NT3@1|root,2ZBRV@2|Bacteria,1V1C2@1239|Firmicutes,4HFYQ@91061|Bacilli,1ZFIE@1386|Bacillus	91061|Bacilli	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
HKD1_k127_1285233_8	309801.trd_0767	7.074e-114	378.0	COG1062@1|root,COG1062@2|Bacteria,2G7KZ@200795|Chloroflexi,27XUS@189775|Thermomicrobia	189775|Thermomicrobia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1285233_14	315749.Bcer98_2119	4.068e-48	177.0	COG2606@1|root,COG2606@2|Bacteria,1TTR4@1239|Firmicutes,4I2YF@91061|Bacilli,1ZEIT@1386|Bacillus	91061|Bacilli	S	Prolyl-tRNA synthetase	-	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_1285233_15	290397.Adeh_0794	3.562e-42	162.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,43AKN@68525|delta/epsilon subdivisions,2X60M@28221|Deltaproteobacteria,2Z1JH@29|Myxococcales	28221|Deltaproteobacteria	K	Putative zinc-finger	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
HKD1_k127_1285233_23	483219.LILAB_14250	2.376e-13	73.0	2DTSQ@1|root,33MH7@2|Bacteria,1NGXY@1224|Proteobacteria,42XSM@68525|delta/epsilon subdivisions,2WSY2@28221|Deltaproteobacteria,2Z0X4@29|Myxococcales	28221|Deltaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_1285233_1	398767.Glov_1719	1.099e-172	550.0	28I8B@1|root,2Z8B5@2|Bacteria,1MUNM@1224|Proteobacteria,42NZH@68525|delta/epsilon subdivisions,2WKHB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c bacterial	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Cytochrome_C7,Cytochrome_cB
HKD1_k127_1285233_9	858215.Thexy_0080	4.49e-98	327.0	COG0730@1|root,COG0730@2|Bacteria,1TPMA@1239|Firmicutes,249II@186801|Clostridia,42FVW@68295|Thermoanaerobacterales	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_1285233_27	626522.GCWU000325_02539	0.0001806	52.0	COG4272@1|root,COG4272@2|Bacteria,4PGF1@976|Bacteroidetes,2G1NN@200643|Bacteroidia,1WDYK@1283313|Alloprevotella	976|Bacteroidetes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1634
HKD1_k127_1285233_26	429009.Adeg_1544	1.246e-08	60.0	COG2331@1|root,COG2331@2|Bacteria,1VM29@1239|Firmicutes,24USJ@186801|Clostridia,42IT8@68295|Thermoanaerobacterales	186801|Clostridia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_1285233_17	670292.JH26_18865	1.874e-34	136.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,1JVD0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_1285233_12	671143.DAMO_1931	1.783e-72	259.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_1292164_1	574087.Acear_1443	3.54e-21	97.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,3WACI@53433|Halanaerobiales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_1292164_0	171693.BN988_00856	5.86e-68	242.0	COG1230@1|root,COG1230@2|Bacteria,1TR92@1239|Firmicutes,4HBCQ@91061|Bacilli,23IY7@182709|Oceanobacillus	91061|Bacilli	P	Cation efflux family	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD1_k127_1296205_0	1386089.N865_04180	6.145e-125	429.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HKD1_k127_1296205_1	189753.AXAS01000012_gene4337	1.018e-59	221.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_1313_20	671143.DAMO_2077	2.114e-64	226.0	COG0020@1|root,COG0020@2|Bacteria,2NP9M@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	GO:0002094,GO:0003674,GO:0003824,GO:0004659,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0071704,GO:1901576,GO:1901615,GO:1901617	2.5.1.31,2.5.1.68	ko:K00806,ko:K12503	ko00900,ko01110,map00900,map01110	-	R06447,R08528	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_1313_23	1408422.JHYF01000010_gene3265	4.175e-14	73.0	COG0695@1|root,COG0695@2|Bacteria	2|Bacteria	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	nrdH	-	-	ko:K06191	-	-	-	-	ko00000	-	-	-	Glutaredoxin
HKD1_k127_1313_0	1121920.AUAU01000004_gene642	0.0	1184.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria	57723|Acidobacteria	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD1_k127_1313_8	292459.STH540	4.241e-133	432.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	namA	-	1.6.99.1	ko:K00354	-	-	R00282	RC00001	ko00000,ko01000	-	-	-	Oxidored_FMN
HKD1_k127_1313_16	1499967.BAYZ01000154_gene1504	4.05e-90	314.0	COG0591@1|root,COG0591@2|Bacteria,2NRKN@2323|unclassified Bacteria	2|Bacteria	E	Sodium:solute symporter family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD1_k127_1313_3	1121456.ATVA01000012_gene2869	4.074e-168	539.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2M8RC@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1313_14	443143.GM18_0360	8.768e-95	319.0	COG0410@1|root,COG0410@2|Bacteria,1R93H@1224|Proteobacteria,42Z1V@68525|delta/epsilon subdivisions,2WUI3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_1313_15	443143.GM18_0361	1.413e-93	318.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42YQS@68525|delta/epsilon subdivisions,2WUCI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_1313_9	1125863.JAFN01000001_gene1330	8.722e-120	392.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,43AW2@68525|delta/epsilon subdivisions,2X6A9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_1313_11	1125863.JAFN01000001_gene1329	1.579e-114	376.0	COG0559@1|root,COG0559@2|Bacteria,1MXHF@1224|Proteobacteria,42YKY@68525|delta/epsilon subdivisions,2WUCY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_1313_4	1125863.JAFN01000001_gene1328	2.695e-162	520.0	COG0683@1|root,COG0683@2|Bacteria,1NHBN@1224|Proteobacteria,42RYV@68525|delta/epsilon subdivisions,2WNEF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_1313_2	1288494.EBAPG3_26360	3.258e-195	636.0	COG0308@1|root,COG0308@2|Bacteria,1PVVK@1224|Proteobacteria,2VIU3@28216|Betaproteobacteria,3722N@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD1_k127_1313_12	305700.B447_18023	1.311e-113	379.0	COG0265@1|root,COG3016@1|root,COG0265@2|Bacteria,COG3016@2|Bacteria,1MX1I@1224|Proteobacteria,2VPEA@28216|Betaproteobacteria,2KXIP@206389|Rhodocyclales	206389|Rhodocyclales	O	Haem-binding uptake, Tiki superfamily, ChaN	-	-	-	-	-	-	-	-	-	-	-	-	Cofac_haem_bdg,PDZ_2
HKD1_k127_1313_19	501479.ACNW01000113_gene4018	1.132e-82	291.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_1313_24	760142.Hipma_0532	1.046e-13	78.0	COG4665@1|root,COG4665@2|Bacteria,1QWP8@1224|Proteobacteria,42U9U@68525|delta/epsilon subdivisions,2WR0R@28221|Deltaproteobacteria,2M79F@213113|Desulfurellales	28221|Deltaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_1313_22	1123247.AUIJ01000036_gene1402	4.409e-16	93.0	COG4663@1|root,COG4663@2|Bacteria,1R2K7@1224|Proteobacteria	1224|Proteobacteria	Q	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_1313_13	1195236.CTER_5299	5.489e-108	365.0	COG0493@1|root,COG0493@2|Bacteria,1V14A@1239|Firmicutes,24FJ4@186801|Clostridia,3WP0B@541000|Ruminococcaceae	186801|Clostridia	C	Dihydroorotate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	DHO_dh,Fer4,Fer4_20
HKD1_k127_1313_17	1121035.AUCH01000001_gene1947	9.782e-87	298.0	COG0697@1|root,COG0697@2|Bacteria,1NEYM@1224|Proteobacteria,2VIII@28216|Betaproteobacteria,2KWBA@206389|Rhodocyclales	206389|Rhodocyclales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_1313_6	1187851.A33M_0952	1.153e-150	488.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2TSCJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD1_k127_1313_18	697303.Thewi_1729	2.137e-84	302.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia	186801|Clostridia	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_1313_21	556261.HMPREF0240_00422	2.726e-21	109.0	COG0407@1|root,COG0407@2|Bacteria,1W13C@1239|Firmicutes,24TPG@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_1313_5	1095769.CAHF01000021_gene918	2.801e-161	516.0	COG1744@1|root,COG1744@2|Bacteria,1MWTM@1224|Proteobacteria,2VH5W@28216|Betaproteobacteria,476JW@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HKD1_k127_1313_10	1121033.AUCF01000013_gene1603	8.01e-116	385.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,2TSGJ@28211|Alphaproteobacteria,2JQ12@204441|Rhodospirillales	204441|Rhodospirillales	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_1313_7	93220.LV28_01230	1.003e-136	446.0	COG4603@1|root,COG4603@2|Bacteria,1MX6V@1224|Proteobacteria,2VH2R@28216|Betaproteobacteria,1K49S@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_1313_1	497321.C664_16935	1.423e-203	647.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,2WGJY@28216|Betaproteobacteria,2KUT1@206389|Rhodocyclales	206389|Rhodocyclales	S	transport systems, ATPase components	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_1313_25	1134445.AJJM01000152_gene90	0.000638	51.0	COG0265@1|root,COG0265@2|Bacteria,2GK4U@201174|Actinobacteria	201174|Actinobacteria	O	Trypsin-like peptidase domain	-	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Trypsin_2
HKD1_k127_1315_14	1047013.AQSP01000091_gene641	7.856e-43	166.0	COG1905@1|root,COG1905@2|Bacteria,2NPSB@2323|unclassified Bacteria	2|Bacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_1315_18	335543.Sfum_2441	4.9e-08	60.0	299YV@1|root,2ZX0J@2|Bacteria,1P75H@1224|Proteobacteria,432SS@68525|delta/epsilon subdivisions,2WY0Q@28221|Deltaproteobacteria,2MSEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1315_2	909663.KI867150_gene971	2.324e-169	546.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2X1VS@28221|Deltaproteobacteria,2MRES@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1315_6	909663.KI867150_gene970	4.929e-110	370.0	COG4191@1|root,COG4191@2|Bacteria,1R89N@1224|Proteobacteria,42QDX@68525|delta/epsilon subdivisions,2WKNA@28221|Deltaproteobacteria,2MR83@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS
HKD1_k127_1315_0	880072.Desac_1402	0.0	1336.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_1315_7	63737.Npun_F1045	2.205e-105	359.0	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria,1HR9W@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_1315_16	1173028.ANKO01000193_gene5855	1.591e-11	71.0	COG1357@1|root,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD1_k127_1315_15	1121396.KB893121_gene3060	2.034e-12	72.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MIMV@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
HKD1_k127_1315_9	1121405.dsmv_2020	8.274e-101	333.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,42VTP@68525|delta/epsilon subdivisions,2X5B0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HKD1_k127_1315_12	671143.DAMO_2771	1.247e-80	284.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
HKD1_k127_1315_17	313612.L8106_15749	1.175e-10	72.0	COG0457@1|root,COG4421@1|root,COG0457@2|Bacteria,COG4421@2|Bacteria,1G22H@1117|Cyanobacteria,1H8WY@1150|Oscillatoriales	1117|Cyanobacteria	G	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF563,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_7,TPR_8
HKD1_k127_1315_13	251221.35213066	7.775e-59	211.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD1_k127_1315_1	309801.trd_1952	5.248e-241	759.0	COG0747@1|root,COG0747@2|Bacteria,2GASZ@200795|Chloroflexi,27YY9@189775|Thermomicrobia	189775|Thermomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_1315_3	309801.trd_1951	8.452e-135	437.0	COG0601@1|root,COG0601@2|Bacteria,2GAQS@200795|Chloroflexi,27YWJ@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_1315_8	1382356.JQMP01000001_gene963	8.278e-103	343.0	COG1173@1|root,COG1173@2|Bacteria,2G8EC@200795|Chloroflexi,27YUP@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_1315_4	1382356.JQMP01000001_gene960	4.744e-127	413.0	COG0444@1|root,COG0444@2|Bacteria,2GBE3@200795|Chloroflexi,27Z2B@189775|Thermomicrobia	189775|Thermomicrobia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_1315_5	1382356.JQMP01000001_gene959	7.17e-118	400.0	COG4608@1|root,COG4608@2|Bacteria,2GARG@200795|Chloroflexi,27Z3W@189775|Thermomicrobia	189775|Thermomicrobia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_1315_10	1089545.KB913037_gene1220	2.366e-91	314.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_1315_11	374847.Kcr_1548	1.218e-87	300.0	COG1052@1|root,arCOG01755@2157|Archaea	2157|Archaea	C	D-isomer specific 2-hydroxyacid dehydrogenase	gyaR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0008152,GO:0016491,GO:0016614,GO:0016616,GO:0016618,GO:0030267,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.1.1.26,1.1.1.29	ko:K00015,ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_1318711_7	234267.Acid_7883	2.737e-88	309.0	COG1432@1|root,COG1432@2|Bacteria,3Y64C@57723|Acidobacteria	57723|Acidobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD1_k127_1318711_16	338966.Ppro_0314	1.16e-29	122.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,42VE3@68525|delta/epsilon subdivisions,2WR9Q@28221|Deltaproteobacteria,43V33@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_1318711_12	1125863.JAFN01000001_gene1069	3.717e-44	166.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WRBN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-2	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_1318711_0	671143.DAMO_2457	1.069e-273	849.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_1318711_14	671143.DAMO_2458	4.277e-41	154.0	COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_1318711_18	292459.STH921	6.577e-23	105.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24IAA@186801|Clostridia	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_1318711_22	926554.KI912675_gene2247	2.824e-05	51.0	2DUIA@1|root,32UXB@2|Bacteria	2|Bacteria	S	SPW repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPW
HKD1_k127_1318711_10	864051.BurJ1DRAFT_4722	9.437e-55	206.0	COG2197@1|root,COG2197@2|Bacteria,1RH8D@1224|Proteobacteria,2WEH4@28216|Betaproteobacteria,1KPF7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_1318711_15	1122221.JHVI01000012_gene850	2.931e-36	153.0	COG4585@1|root,COG4585@2|Bacteria,1WJNH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HATPase_c,HATPase_c_2,HisKA_3,PAS,PAS_4,PAS_8
HKD1_k127_1318711_3	706587.Desti_4722	1.181e-161	528.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD1_k127_1318711_11	56780.SYN_00482	1.868e-47	178.0	COG0746@1|root,COG0746@2|Bacteria,1RKCH@1224|Proteobacteria,42T8X@68525|delta/epsilon subdivisions,2WP3Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_1318711_6	671143.DAMO_2129	4.139e-90	319.0	COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria	2|Bacteria	O	CAAX prenyl protease N-terminal, five membrane helices	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD1_k127_1318711_19	1183438.GKIL_2110	8.386e-13	76.0	COG1397@1|root,COG1397@2|Bacteria,1G5Y5@1117|Cyanobacteria	1117|Cyanobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_1318711_20	1469607.KK073768_gene2086	1.881e-11	66.0	COG1397@1|root,COG1397@2|Bacteria,1G5Y5@1117|Cyanobacteria,1HR9M@1161|Nostocales	1117|Cyanobacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_1318711_9	1081640.AGFU01000006_gene1194	9.605e-61	221.0	COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,2TREE@28211|Alphaproteobacteria,2JZZE@204457|Sphingomonadales	204457|Sphingomonadales	Q	ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD1_k127_1318711_1	876269.ARWA01000001_gene241	1.693e-217	690.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3NB0Q@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_1318711_2	596152.DesU5LDRAFT_0189	2.861e-208	658.0	COG2223@1|root,COG2223@2|Bacteria,1QUK3@1224|Proteobacteria,43BJX@68525|delta/epsilon subdivisions,2X6XT@28221|Deltaproteobacteria,2M96G@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_1318711_17	1184607.AUCHE_22_00420	9.948e-26	120.0	COG1612@1|root,COG1612@2|Bacteria,2GQ8W@201174|Actinobacteria	201174|Actinobacteria	O	heme a metabolic process	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD1_k127_1318711_5	1211115.ALIQ01000068_gene3488	1.607e-111	365.0	COG4221@1|root,COG4221@2|Bacteria,1MWXS@1224|Proteobacteria,2TQYY@28211|Alphaproteobacteria,3NB18@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	MA20_32450	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_1318711_4	247633.GP2143_13316	8.802e-134	434.0	COG3618@1|root,COG3618@2|Bacteria,1MVG0@1224|Proteobacteria,1RRC6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_1318711_13	757424.Hsero_3989	1.732e-41	163.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,2VN2W@28216|Betaproteobacteria,472V6@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_1318711_8	639283.Snov_3530	5.932e-79	276.0	COG0673@1|root,COG0673@2|Bacteria,1N1XT@1224|Proteobacteria,2UCWH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_1318711_21	1123060.JONP01000023_gene2651	5.854e-08	55.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TSFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	HMGL-like	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD1_k127_1350889_6	671143.DAMO_0060	9.509e-115	376.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168,ko:K07479	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
HKD1_k127_1350889_4	671143.DAMO_0061	1.096e-164	529.0	COG1206@1|root,COG1206@2|Bacteria,2NS4B@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	GO:0000166,GO:0001510,GO:0002097,GO:0002098,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0050660,GO:0050662,GO:0071704,GO:0090304,GO:0097159,GO:1901265,GO:1901360,GO:1901363	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD1_k127_1350889_8	671143.DAMO_0070	7.724e-100	336.0	COG4974@1|root,COG4974@2|Bacteria,2NP4H@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_1350889_10	1047013.AQSP01000121_gene2717	8.801e-70	244.0	COG5405@1|root,COG5405@2|Bacteria,2NP72@2323|unclassified Bacteria	2|Bacteria	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016787,GO:0017076,GO:0019538,GO:0019904,GO:0022607,GO:0030163,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0051603,GO:0065003,GO:0070003,GO:0070011,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD1_k127_1350889_1	671143.DAMO_0072	5.268e-204	644.0	COG1220@1|root,COG1220@2|Bacteria,2NP00@2323|unclassified Bacteria	2|Bacteria	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	GO:0000166,GO:0000287,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009266,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019904,GO:0022607,GO:0030554,GO:0031597,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034214,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043335,GO:0043933,GO:0044085,GO:0044238,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051259,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD1_k127_1350889_12	1121918.ARWE01000001_gene1059	3.214e-43	172.0	COG0642@1|root,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,43CC6@68525|delta/epsilon subdivisions,2X7N2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA
HKD1_k127_1350889_7	671143.DAMO_0073	1.498e-102	341.0	COG0548@1|root,COG0548@2|Bacteria,2NQHT@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016020,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0030312,GO:0031406,GO:0034618,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10565,iJN678.argB,iLJ478.TM1784	AA_kinase
HKD1_k127_1350889_3	671143.DAMO_0074	5.376e-175	557.0	COG4992@1|root,COG4992@2|Bacteria,2NP1Z@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-III	argD	GO:0003674,GO:0005488,GO:0005515,GO:0008144,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0070279,GO:0097159,GO:1901363	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_0204,iHN637.CLJU_RS10560	Aminotran_3
HKD1_k127_1350889_5	671143.DAMO_0075	1.167e-129	420.0	COG0078@1|root,COG0078@2|Bacteria,2NNWN@2323|unclassified Bacteria	2|Bacteria	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_1350889_11	28042.GU90_06610	1.509e-50	190.0	COG1028@1|root,COG1028@2|Bacteria,2GJGM@201174|Actinobacteria,4E1KU@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_1350889_0	671143.DAMO_0085	9.485e-209	655.0	COG0137@1|root,COG0137@2|Bacteria,2NP01@2323|unclassified Bacteria	2|Bacteria	E	Arginosuccinate synthase	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iJN678.argG,iSB619.SA_RS04675	Arginosuc_synth
HKD1_k127_1350889_2	671143.DAMO_0086	2.639e-189	601.0	COG0165@1|root,COG0165@2|Bacteria,2NP70@2323|unclassified Bacteria	2|Bacteria	E	argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,4.3.2.1	ko:K01755,ko:K14681	ko00220,ko00250,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map01100,map01110,map01130,map01210,map01230	M00028,M00029,M00844,M00845	R00259,R01086	RC00004,RC00064,RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_1350889_9	671143.DAMO_0087	4.811e-75	267.0	COG4733@1|root,COG4733@2|Bacteria,2NQ62@2323|unclassified Bacteria	2|Bacteria	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14,fn3
HKD1_k127_1350889_13	13690.CP98_00718	3.229e-24	111.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria,2KCU9@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_1364522_1	1274524.BSONL12_10167	2.484e-15	78.0	COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,4HNXE@91061|Bacilli,1ZI6R@1386|Bacillus	91061|Bacilli	O	Protein of unknown function (DUF2847)	ytxJ	-	-	-	-	-	-	-	-	-	-	-	DUF2847
HKD1_k127_1364522_2	555779.Dthio_PD1452	1.029e-13	73.0	COG0484@1|root,COG1357@1|root,COG0484@2|Bacteria,COG1357@2|Bacteria	2|Bacteria	S	protein homooligomerization	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	DUF3099,DnaJ,Pentapeptide
HKD1_k127_1413504_0	566461.SSFG_05429	4.019e-116	382.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10233	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1,CarboxypepD_reg,SdrD_B
HKD1_k127_1413504_1	1054860.KB913030_gene94	1.927e-101	347.0	COG0395@1|root,COG0395@2|Bacteria,2GJNN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K10234	ko02010,map02010	M00201	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1
HKD1_k127_1413504_3	381666.H16_A0581	1.347e-06	53.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,1K0B9@119060|Burkholderiaceae	28216|Betaproteobacteria	M	RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_1413504_2	338966.Ppro_2204	3.226e-23	100.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43T46@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K07788,ko:K07789,ko:K18138	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_1424597_2	653386.HMPREF0975_01540	9.225e-09	57.0	2DSQW@1|root,33H3S@2|Bacteria,2GTIV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1424597_0	574087.Acear_0406	5.862e-125	412.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,3WA6J@53433|Halanaerobiales	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD1_k127_1424597_1	1379698.RBG1_1C00001G1562	7.121e-16	82.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
HKD1_k127_1442422_11	765913.ThidrDRAFT_0465	2.666e-08	55.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,1RSJY@1236|Gammaproteobacteria,1WY4B@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_1442422_7	289376.THEYE_A0315	1.1e-15	83.0	COG0582@1|root,COG0582@2|Bacteria,3J133@40117|Nitrospirae	40117|Nitrospirae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_1442422_3	365046.Rta_22780	7.5e-52	188.0	2C6PE@1|root,333XY@2|Bacteria,1R3CF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1442422_12	347834.RHE_CH01407	1.604e-06	55.0	COG1051@1|root,COG1051@2|Bacteria,1N1KH@1224|Proteobacteria,2UA1K@28211|Alphaproteobacteria,4BEK8@82115|Rhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the Nudix hydrolase family	nudF	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_1442422_10	1173024.KI912148_gene4129	7.512e-09	61.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3,GrpB,NUDIX
HKD1_k127_1442422_5	379066.GAU_2184	2.843e-35	143.0	COG1670@1|root,COG1670@2|Bacteria,1ZUYQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_1442422_4	556261.HMPREF0240_00555	1.493e-35	152.0	COG0407@1|root,COG0407@2|Bacteria,1URPV@1239|Firmicutes,24XIW@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_1442422_1	1040983.AXAE01000038_gene2569	7.528e-63	231.0	COG3964@1|root,COG3964@2|Bacteria,1MVC7@1224|Proteobacteria,2TSUD@28211|Alphaproteobacteria,43J9W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Amidohydrolase family	MA20_40145	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1442422_2	1305836.AXVE01000011_gene1075	1.701e-61	224.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,4HCIH@91061|Bacilli,26DRW@186818|Planococcaceae	91061|Bacilli	G	TRAP-type C4-dicarboxylate transport system, periplasmic	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_1442422_6	1120956.JHZK01000012_gene3651	5.536e-21	98.0	COG3090@1|root,COG3090@2|Bacteria,1N7V7@1224|Proteobacteria,2VCDP@28211|Alphaproteobacteria,1JPCK@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_1442422_0	1380394.JADL01000004_gene6127	1.658e-129	434.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQGA@204441|Rhodospirillales	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_1449339_5	768706.Desor_4279	7.827e-73	269.0	COG0247@1|root,COG0247@2|Bacteria,1TR46@1239|Firmicutes,24EGE@186801|Clostridia	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
HKD1_k127_1449339_0	767817.Desgi_2701	1.067e-159	517.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1449339_2	1038860.AXAP01000001_gene6374	2.651e-107	364.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,2TT6G@28211|Alphaproteobacteria,3JWEQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1449339_4	1499967.BAYZ01000019_gene6298	2.434e-79	272.0	COG0744@1|root,COG0744@2|Bacteria,2NRF9@2323|unclassified Bacteria	2|Bacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129,3.4.16.4	ko:K03814,ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD1_k127_1449339_1	572547.Amico_0090	3.335e-121	406.0	COG1593@1|root,COG1593@2|Bacteria,3TA8I@508458|Synergistetes	508458|Synergistetes	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_1449339_6	572547.Amico_0089	1.886e-23	106.0	COG3090@1|root,COG3090@2|Bacteria,3TCAW@508458|Synergistetes	508458|Synergistetes	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_1449339_3	1449126.JQKL01000008_gene233	1.282e-99	336.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,269C3@186813|unclassified Clostridiales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_145360_5	671143.DAMO_2705	6.228e-173	549.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD1_k127_145360_1	671143.DAMO_2706	2.985e-282	880.0	COG1009@1|root,COG1009@2|Bacteria,2NNM8@2323|unclassified Bacteria	2|Bacteria	CP	NADH-quinone oxidoreductase chain L	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_145360_15	671143.DAMO_2707	1.223e-43	160.0	COG0713@1|root,COG0713@2|Bacteria,2NQ6R@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_145360_14	671143.DAMO_2708	1.345e-45	170.0	COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	ndhG	-	1.6.5.3	ko:K00339,ko:K05578	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_145360_8	671143.DAMO_2709	1.3e-125	413.0	COG1005@1|root,COG1005@2|Bacteria,2NQIK@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0008137,GO:0008150,GO:0008152,GO:0009987,GO:0015980,GO:0016491,GO:0016651,GO:0016655,GO:0044237,GO:0045333,GO:0050136,GO:0055114	1.6.5.3	ko:K00337,ko:K05572	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_145360_4	671143.DAMO_2710	1.009e-190	601.0	COG0649@1|root,COG0649@2|Bacteria,2NNXB@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_145360_12	671143.DAMO_2711	5.995e-51	188.0	COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD1_k127_145360_10	671143.DAMO_2712	5.01e-52	188.0	COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0050136,GO:0055114,GO:0098796,GO:1902494	1.6.5.3	ko:K00330,ko:K05574	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_145360_0	1121918.ARWE01000001_gene386	0.0	1015.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,42NYP@68525|delta/epsilon subdivisions,2WIPJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_145360_13	1380394.JADL01000007_gene4661	5.182e-47	177.0	2DMMP@1|root,32SHG@2|Bacteria,1RM15@1224|Proteobacteria,2UAH7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_145360_2	765911.Thivi_3147	4.446e-273	875.0	COG1061@1|root,COG1061@2|Bacteria,1MWY3@1224|Proteobacteria,1S2A3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KL	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ResIII
HKD1_k127_145360_19	880072.Desac_1390	2.707e-06	61.0	COG1708@1|root,COG1708@2|Bacteria,1NIDP@1224|Proteobacteria,433AV@68525|delta/epsilon subdivisions,2WY5Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD1_k127_145360_16	518766.Rmar_2146	4.707e-37	144.0	COG2250@1|root,COG2250@2|Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
HKD1_k127_145360_3	765911.Thivi_3144	5.987e-218	697.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,1RNHM@1236|Gammaproteobacteria,1WW54@135613|Chromatiales	135613|Chromatiales	L	PFAM DNA methylase	-	-	2.1.1.72	ko:K07319	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_145360_17	671143.DAMO_3050	9.116e-31	124.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_145360_18	706587.Desti_0347	6.122e-11	74.0	2DPS5@1|root,3335G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2703
HKD1_k127_145360_7	1411123.JQNH01000001_gene2879	1.987e-135	444.0	COG0477@1|root,COG2814@2|Bacteria,1MXPM@1224|Proteobacteria,2TSB9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_145360_6	525904.Tter_2663	2.119e-147	478.0	COG2059@1|root,COG2059@2|Bacteria,2NPUT@2323|unclassified Bacteria	2|Bacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_145360_9	643648.Slip_0474	1.846e-80	290.0	COG0699@1|root,COG0699@2|Bacteria,1TR0Q@1239|Firmicutes,24BWJ@186801|Clostridia	186801|Clostridia	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD1_k127_145360_11	570952.ATVH01000011_gene578	1.522e-51	187.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,2VBUK@28211|Alphaproteobacteria,2JX3C@204441|Rhodospirillales	204441|Rhodospirillales	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
HKD1_k127_1457513_1	671143.DAMO_0996	8.317e-224	705.0	COG1067@1|root,COG4987@1|root,COG1067@2|Bacteria,COG4987@2|Bacteria,2NP29@2323|unclassified Bacteria	2|Bacteria	O	peptidase S16	cydC	-	3.4.21.53	ko:K01338,ko:K04076,ko:K04770,ko:K16012,ko:K16014	ko02010,ko04112,map02010,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000	3.A.1.129	-	-	AAA_32,ABC_membrane,ABC_tran,Lon_C
HKD1_k127_1457513_0	1144319.PMI16_02559	2.637e-277	871.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2W0KT@28216|Betaproteobacteria,476SR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_1457513_4	243924.LT42_00445	2.209e-60	213.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S58P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	2Fe-2S -binding domain protein	-	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016725,GO:0019439,GO:0044237,GO:0044248,GO:0055114	1.17.2.1	ko:K18029	ko00760,ko01120,map00760,map01120	M00622	R09473	RC00589	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_1457513_5	448385.sce9006	6.66e-53	200.0	COG1816@1|root,COG1816@2|Bacteria,1MWBV@1224|Proteobacteria,42UJZ@68525|delta/epsilon subdivisions,2WQCC@28221|Deltaproteobacteria,2YV77@29|Myxococcales	28221|Deltaproteobacteria	F	adenosine deaminase	add	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HKD1_k127_1457513_2	1125973.JNLC01000010_gene1162	2.215e-62	228.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TT0P@28211|Alphaproteobacteria,3K63K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Arginase family	speB_1	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_1457513_3	1499967.BAYZ01000163_gene6599	6.508e-62	223.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_1461928_6	395495.Lcho_0054	2.671e-24	104.0	COG0642@1|root,COG2205@2|Bacteria,1N58A@1224|Proteobacteria,2VHVP@28216|Betaproteobacteria,1KN51@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Histidine kinase	yfhK	-	2.7.13.3	ko:K07711	ko02020,ko02024,map02020,map02024	M00502	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1461928_5	1096546.WYO_5676	7.517e-38	146.0	2DNM2@1|root,32Y26@2|Bacteria,1N7KR@1224|Proteobacteria,2UI2G@28211|Alphaproteobacteria,1JVBG@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HKD1_k127_1461928_3	1121106.JQKB01000010_gene445	6.272e-105	350.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,2JRVP@204441|Rhodospirillales	204441|Rhodospirillales	S	Epoxide hydrolase N terminus	-	-	3.3.2.9	ko:K01253	ko00980,ko04976,ko05204,map00980,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
HKD1_k127_1461928_4	485913.Krac_4939	1.582e-80	279.0	COG2120@1|root,COG2120@2|Bacteria,2G9IP@200795|Chloroflexi	200795|Chloroflexi	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_1461928_1	869210.Marky_1927	2.66e-175	572.0	COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_1461928_0	1454004.AW11_02730	0.0	1188.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_1461928_2	1298867.AUES01000023_gene2771	4.322e-157	499.0	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria,3JX2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_1461928_7	398767.Glov_0712	2.082e-23	100.0	COG0371@1|root,COG0371@2|Bacteria,1MWAE@1224|Proteobacteria,42PJS@68525|delta/epsilon subdivisions,2WJ69@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.6	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	-	R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_148000_0	744872.Spica_0065	3.155e-168	543.0	2BXG3@1|root,2Z82R@2|Bacteria,2J6D3@203691|Spirochaetes	203691|Spirochaetes	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
HKD1_k127_148000_3	1499967.BAYZ01000177_gene5729	3.8e-31	135.0	COG0207@1|root,COG0207@2|Bacteria	2|Bacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD1_k127_148000_2	2002.JOEQ01000012_gene5740	2.404e-31	131.0	COG0586@1|root,COG0586@2|Bacteria,2GKKC@201174|Actinobacteria	201174|Actinobacteria	I	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_148000_1	215803.DB30_4065	1.001e-68	241.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,42ZK4@68525|delta/epsilon subdivisions,2WUTV@28221|Deltaproteobacteria,2YVBM@29|Myxococcales	28221|Deltaproteobacteria	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD1_k127_1510855_2	1499967.BAYZ01000039_gene2221	3.25e-31	132.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_1510855_1	266117.Rxyl_0316	3.532e-311	969.0	COG0296@1|root,COG0296@2|Bacteria,2GJ5C@201174|Actinobacteria,4CP7U@84995|Rubrobacteria	84995|Rubrobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_1510855_0	247490.KSU1_B0323	0.0	1093.0	COG1523@1|root,COG1523@2|Bacteria,2IX65@203682|Planctomycetes	203682|Planctomycetes	G	Carbohydrate-binding module 48 (Isoamylase N-terminal domain)	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_1510855_3	671143.DAMO_1542	5.263e-26	118.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HTH_8,Mrr_cat,Response_reg,SpoIIE
HKD1_k127_1510855_4	671143.DAMO_1544	2.207e-05	51.0	COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1529041_0	671143.DAMO_0421	3.34e-171	550.0	COG0513@1|root,COG0513@2|Bacteria,2NP0A@2323|unclassified Bacteria	2|Bacteria	JKL	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K03732,ko:K05592,ko:K11927	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_1529041_1	1232410.KI421412_gene435	2.356e-79	281.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,42PI3@68525|delta/epsilon subdivisions,2WJN3@28221|Deltaproteobacteria,43TSZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	RNA pseudouridylate synthase	-	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD1_k127_1529041_2	671143.DAMO_2125	2.22e-41	154.0	COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria	2|Bacteria	S	RNA recognition motif	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_1529041_3	671143.DAMO_2124	1.877e-20	94.0	COG0828@1|root,COG0828@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_1529041_4	1379698.RBG1_1C00001G0140	5.799e-15	78.0	COG1278@1|root,COG1278@2|Bacteria	2|Bacteria	K	Cold shock	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD,Excalibur
HKD1_k127_1534742_3	879309.HMPREF9199_1286	1.251e-14	84.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,4H5DY@909932|Negativicutes	909932|Negativicutes	I	glutaconyl-CoA decarboxylase subunit gamma	gcdC	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Biotin_lipoyl
HKD1_k127_1534742_0	1121472.AQWN01000011_gene1255	1.744e-177	569.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,26167@186807|Peptococcaceae	186801|Clostridia	C	Conserved carboxylase domain	-	-	4.1.1.3,6.4.1.1	ko:K01571,ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00217,R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000,ko02000	3.B.1.1.1	-	-	Biotin_lipoyl,HMGL-like,PYC_OADA
HKD1_k127_1534742_1	1191523.MROS_1715	2.738e-94	323.0	COG0635@1|root,COG0635@2|Bacteria	2|Bacteria	H	coproporphyrinogen oxidase activity	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_1534742_2	1463887.KL589954_gene7191	3.684e-28	120.0	COG2318@1|root,COG2318@2|Bacteria,2GXK3@201174|Actinobacteria	201174|Actinobacteria	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_1538915_0	903818.KI912268_gene1318	5.911e-160	512.0	COG0702@1|root,COG0702@2|Bacteria,3Y7DF@57723|Acidobacteria	57723|Acidobacteria	GM	Protein of unknown function (DUF2867)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD1_k127_1538915_1	696369.KI912183_gene1891	6.426e-36	154.0	COG0265@1|root,COG0265@2|Bacteria,1UYZJ@1239|Firmicutes	1239|Firmicutes	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_1538915_2	314278.NB231_04435	1.786e-13	78.0	2EGDK@1|root,33A5G@2|Bacteria,1NIIK@1224|Proteobacteria,1SUBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1538915_3	1206725.BAFU01000070_gene6024	1.291e-10	68.0	COG4244@1|root,COG4244@2|Bacteria,2II9W@201174|Actinobacteria,4G94C@85025|Nocardiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD1_k127_154992_3	243164.DET0166	1.296e-59	212.0	COG2801@1|root,COG2801@2|Bacteria,2G8GQ@200795|Chloroflexi,34DDP@301297|Dehalococcoidia	301297|Dehalococcoidia	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD1_k127_154992_8	1124991.MU9_112	5.826e-21	93.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,1RR8F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD1_k127_154992_0	1123367.C666_01500	1.256e-126	409.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2VK6T@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_154992_1	643648.Slip_0474	5.203e-90	317.0	COG0699@1|root,COG0699@2|Bacteria,1TR0Q@1239|Firmicutes,24BWJ@186801|Clostridia	186801|Clostridia	S	Dynamin family	-	-	-	-	-	-	-	-	-	-	-	-	Dynamin_N
HKD1_k127_154992_7	926561.KB900618_gene107	2.793e-21	99.0	COG1418@1|root,COG1418@2|Bacteria,1UVYG@1239|Firmicutes,25MMF@186801|Clostridia,3WC72@53433|Halanaerobiales	186801|Clostridia	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_154992_4	269799.Gmet_2744	9.867e-38	146.0	COG3753@1|root,COG3753@2|Bacteria,1N7FF@1224|Proteobacteria,42XCB@68525|delta/epsilon subdivisions,2WWYM@28221|Deltaproteobacteria,43VES@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HKD1_k127_154992_5	909663.KI867150_gene1398	1.846e-34	141.0	COG1555@1|root,COG1555@2|Bacteria,1Q2CD@1224|Proteobacteria,437YR@68525|delta/epsilon subdivisions,2X38P@28221|Deltaproteobacteria,2MSET@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
HKD1_k127_154992_6	909663.KI867150_gene1399	5.738e-26	117.0	2CFNS@1|root,331AJ@2|Bacteria,1NBYG@1224|Proteobacteria,42VZ5@68525|delta/epsilon subdivisions,2WR8A@28221|Deltaproteobacteria,2MS7D@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_154992_2	880072.Desac_0212	1.025e-60	214.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,2MRIV@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_1557139_6	1123060.JONP01000001_gene1310	2.073e-05	48.0	COG2271@1|root,COG2271@2|Bacteria,1R8Q1@1224|Proteobacteria,2U16E@28211|Alphaproteobacteria,2JV4J@204441|Rhodospirillales	204441|Rhodospirillales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_1557139_3	290397.Adeh_2253	4.642e-216	692.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,43BKG@68525|delta/epsilon subdivisions,2X6YU@28221|Deltaproteobacteria,2YYW6@29|Myxococcales	28221|Deltaproteobacteria	K	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,PAS_9,Sigma54_activat
HKD1_k127_1557139_2	861299.J421_0622	1.487e-237	741.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
HKD1_k127_1557139_5	861299.J421_0621	4.139e-64	236.0	2AI77@1|root,318MJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1557139_1	296591.Bpro_1506	1.119e-245	766.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria,4AD4J@80864|Comamonadaceae	28216|Betaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD1_k127_1557139_4	1282876.BAOK01000001_gene2139	8.717e-66	231.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM ThiJ PfpI domain protein	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_1557139_0	1267535.KB906767_gene1227	9.969e-253	784.0	COG0277@1|root,COG0277@2|Bacteria,3Y36Q@57723|Acidobacteria	57723|Acidobacteria	C	PFAM FAD linked oxidase	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD1_k127_1560928_10	189753.AXAS01000030_gene7102	1.425e-74	261.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_1560928_19	1122179.KB890480_gene3150	9.069e-08	57.0	295U4@1|root,2ZT58@2|Bacteria,4PQ2P@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_1560928_18	1120948.KB903224_gene366	1.237e-09	66.0	2AVNR@1|root,31MFR@2|Bacteria,2HBMC@201174|Actinobacteria	1120948.KB903224_gene366|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1560928_1	543728.Vapar_0459	5.214e-208	671.0	COG4122@1|root,COG4122@2|Bacteria,1QWCT@1224|Proteobacteria,2VJBK@28216|Betaproteobacteria,4ACMD@80864|Comamonadaceae	28216|Betaproteobacteria	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1560928_8	207559.Dde_0137	1.135e-95	324.0	COG1079@1|root,COG1079@2|Bacteria,1MVDQ@1224|Proteobacteria,42P6E@68525|delta/epsilon subdivisions,2WISH@28221|Deltaproteobacteria,2M9UN@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Branched-chain amino acid transport system / permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_1560928_6	1121423.JONT01000011_gene232	2.006e-105	357.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,260XA@186807|Peptococcaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_1560928_4	641491.DND132_0591	7.279e-141	468.0	COG3845@1|root,COG3845@2|Bacteria,1NT0H@1224|Proteobacteria,42NTY@68525|delta/epsilon subdivisions,2WK4F@28221|Deltaproteobacteria,2M8EW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ABC transporter related	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_1560928_2	1379281.AVAG01000026_gene1668	1.591e-157	506.0	COG1744@1|root,COG1744@2|Bacteria,1NS9V@1224|Proteobacteria,42ZD1@68525|delta/epsilon subdivisions,2WTZN@28221|Deltaproteobacteria,2M8YZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD1_k127_1560928_15	926550.CLDAP_31530	3.683e-56	209.0	COG0697@1|root,COG0697@2|Bacteria,2G70T@200795|Chloroflexi	200795|Chloroflexi	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_1560928_5	671143.DAMO_0321	1.555e-137	449.0	COG1570@1|root,COG1570@2|Bacteria,2NNQT@2323|unclassified Bacteria	2|Bacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6,3.4.21.102	ko:K03601,ko:K03797	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD1_k127_1560928_17	56780.SYN_02458	2.924e-13	79.0	COG1722@1|root,COG1722@2|Bacteria,1Q1MM@1224|Proteobacteria,42X37@68525|delta/epsilon subdivisions,2WSNI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD1_k127_1560928_7	404380.Gbem_1257	1.143e-97	328.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,42NPN@68525|delta/epsilon subdivisions,2WIY4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_1560928_0	398767.Glov_2235	1.164e-229	728.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,42M35@68525|delta/epsilon subdivisions,2WIX5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_1560928_12	671143.DAMO_0324	8.039e-68	259.0	COG1189@1|root,COG1189@2|Bacteria,2NPHR@2323|unclassified Bacteria	2|Bacteria	J	FtsJ-like methyltransferase	tlyA	GO:0000154,GO:0001510,GO:0001897,GO:0001906,GO:0001907,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0019835,GO:0019836,GO:0022613,GO:0031167,GO:0031640,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0035821,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044003,GO:0044004,GO:0044085,GO:0044179,GO:0044237,GO:0044238,GO:0044260,GO:0044364,GO:0044403,GO:0044419,GO:0044764,GO:0046483,GO:0051701,GO:0051704,GO:0051715,GO:0051801,GO:0051817,GO:0051818,GO:0051883,GO:0052331,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD1_k127_1560928_9	671143.DAMO_0325	4.578e-95	319.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
HKD1_k127_1560928_3	671143.DAMO_0326	8.618e-156	510.0	COG0497@1|root,COG0497@2|Bacteria,2NNUS@2323|unclassified Bacteria	2|Bacteria	L	May be involved in recombinational repair of damaged DNA	recN	GO:0000724,GO:0000725,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009295,GO:0009314,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0030312,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:1901360	-	ko:K03631,ko:K13582	ko04112,map04112	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
HKD1_k127_1560928_13	1125863.JAFN01000001_gene2856	5.107e-64	233.0	COG0614@1|root,COG0614@2|Bacteria,1MWVF@1224|Proteobacteria,42PQA@68525|delta/epsilon subdivisions,2WKNZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_1560928_11	555088.DealDRAFT_0688	1.762e-71	254.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,42JXY@68298|Syntrophomonadaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_1560928_14	330214.NIDE2672	3.721e-57	214.0	COG1120@1|root,COG1120@2|Bacteria,3J14U@40117|Nitrospirae	40117|Nitrospirae	HP	ABC transporter	-	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD1_k127_1560928_16	671143.DAMO_0102	2.593e-28	124.0	COG4772@1|root,COG4772@2|Bacteria,2NRIP@2323|unclassified Bacteria	2|Bacteria	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD1_k127_1575252_1	1469245.JFBG01000068_gene15	4.379e-80	270.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria,1X10G@135613|Chromatiales	135613|Chromatiales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_1575252_2	94624.Bpet3294	2.799e-62	235.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria	1224|Proteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.156,4.2.1.42	ko:K20023	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_1575252_0	1242864.D187_008565	3.437e-110	361.0	COG3967@1|root,COG3967@2|Bacteria,1QSYJ@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K14189	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
HKD1_k127_1575252_3	1122201.AUAZ01000012_gene1344	1.039e-40	156.0	COG1765@1|root,COG1765@2|Bacteria,1QUE7@1224|Proteobacteria,1S84Z@1236|Gammaproteobacteria,466R0@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_1575252_5	1128421.JAGA01000002_gene1331	2.623e-20	94.0	2ED7R@1|root,3374C@2|Bacteria,2NS2D@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1575252_7	634498.mru_0819	0.0001577	50.0	COG4010@1|root,arCOG04906@2157|Archaea,2XZ3A@28890|Euryarchaeota,23P5J@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized protein conserved in archaea (DUF2096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2096
HKD1_k127_1575252_8	1121918.ARWE01000001_gene35	0.0008042	51.0	COG0746@1|root,COG1526@1|root,COG1763@1|root,COG0746@2|Bacteria,COG1526@2|Bacteria,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,42RZK@68525|delta/epsilon subdivisions,2WQ3C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	TIGRFAM Molybdopterin-guanine dinucleotide biosynthesis protein B	mobB	-	2.7.7.77	ko:K03753,ko:K13818	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	MobB,NTP_transf_3
HKD1_k127_1575252_4	536227.CcarbDRAFT_5133	5.362e-32	139.0	2E19M@1|root,32WPW@2|Bacteria,1VCY5@1239|Firmicutes,24I3Z@186801|Clostridia,36IZS@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1575252_6	643648.Slip_1431	7.992e-20	100.0	COG3058@1|root,COG3058@2|Bacteria,1VJXM@1239|Firmicutes,25DK9@186801|Clostridia,42KN0@68298|Syntrophomonadaceae	186801|Clostridia	C	Necessary for formate dehydrogenase activity	-	-	-	ko:K02380	-	-	-	-	ko00000	-	-	-	FdhE
HKD1_k127_1576761_1	1123274.KB899411_gene3184	1.979e-21	99.0	COG0451@1|root,COG0451@2|Bacteria,2J5DY@203691|Spirochaetes	203691|Spirochaetes	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_1576761_0	404380.Gbem_1025	1.957e-55	205.0	29PPX@1|root,30AN2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1576761_2	909663.KI867150_gene11	4.696e-18	85.0	COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,42QX9@68525|delta/epsilon subdivisions,2WKS8@28221|Deltaproteobacteria,2MRU4@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08224	-	-	-	-	ko00000,ko02000	2.A.1.36	-	-	MFS_1
HKD1_k127_1608433_3	1267005.KB911266_gene1243	6.912e-09	59.0	COG1670@1|root,COG1670@2|Bacteria,1RF8W@1224|Proteobacteria,2U707@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD1_k127_1608433_0	706587.Desti_1627	2.433e-69	241.0	COG0491@1|root,COG0491@2|Bacteria,1RJQM@1224|Proteobacteria,42SK3@68525|delta/epsilon subdivisions,2WPR1@28221|Deltaproteobacteria,2MRUG@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_1608433_1	335543.Sfum_1957	7.268e-12	72.0	2EUFT@1|root,33MY2@2|Bacteria,1NMCP@1224|Proteobacteria,42XWX@68525|delta/epsilon subdivisions,2WTB3@28221|Deltaproteobacteria,2MQQ5@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1608433_2	1121405.dsmv_2616	3.635e-11	64.0	COG0492@1|root,COG0492@2|Bacteria,1R82E@1224|Proteobacteria,42PSM@68525|delta/epsilon subdivisions,2WJYX@28221|Deltaproteobacteria,2MN1E@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD1_k127_1631983_0	1434929.X946_3758	4.706e-44	163.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2VIWI@28216|Betaproteobacteria,1K590@119060|Burkholderiaceae	28216|Betaproteobacteria	S	penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD1_k127_1631983_1	582899.Hden_1421	3.041e-12	78.0	COG0697@1|root,COG0745@1|root,COG4191@1|root,COG5002@1|root,COG0697@2|Bacteria,COG0745@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,3N8EP@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_1649402_0	1396418.BATQ01000103_gene5522	9.022e-55	210.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD1_k127_1661516_9	1162668.LFE_0389	2.623e-46	186.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,3J14D@40117|Nitrospirae	40117|Nitrospirae	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
HKD1_k127_1661516_10	330214.NIDE2935	2.454e-29	119.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_1661516_12	330214.NIDE2936	1.144e-27	112.0	COG1598@1|root,COG1598@2|Bacteria,3J1EZ@40117|Nitrospirae	40117|Nitrospirae	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1661516_0	671143.DAMO_1667	0.0	1242.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2NNNY@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.3.13,2.7.9.1	ko:K01006,ko:K22424	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_1661516_1	671143.DAMO_2645	2.183e-251	795.0	COG0751@1|root,COG0751@2|Bacteria,2NNWY@2323|unclassified Bacteria	2|Bacteria	J	Glycyl-tRNA synthetase beta subunit	glyS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046983,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.14	ko:K01879,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAPECO1_1312.APECO1_2891,iE2348C_1286.E2348C_3810,iECABU_c1320.ECABU_c40010,iECED1_1282.ECED1_4242,iECH74115_1262.ECH74115_4934,iECNA114_1301.ECNA114_3710,iECOK1_1307.ECOK1_4005,iECP_1309.ECP_3661,iECS88_1305.ECS88_3976,iECSF_1327.ECSF_3393,iECSP_1301.ECSP_4554,iECs_1301.ECs4442,iG2583_1286.G2583_4300,iJN678.glyS,iUMN146_1321.UM146_17960,iUTI89_1310.UTI89_C4099,ic_1306.c4378	DALR_1,tRNA_synt_2f
HKD1_k127_1661516_2	671143.DAMO_2644	1.618e-157	501.0	COG0752@1|root,COG0752@2|Bacteria,2NNZ3@2323|unclassified Bacteria	2|Bacteria	J	Glycyl-tRNA synthetase, alpha subunit	glyQ	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016874,GO:0016875,GO:0044424,GO:0044444,GO:0044464,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01878,ko:K14164	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF1260.b3560,iAF987.Gmet_2942,iJO1366.b3560,iPC815.YPO4072,iY75_1357.Y75_RS19360	tRNA-synt_2e
HKD1_k127_1661516_7	671143.DAMO_2994	1.349e-59	215.0	COG1381@1|root,COG1381@2|Bacteria	2|Bacteria	L	Involved in DNA repair and RecF pathway recombination	recO	GO:0008150,GO:0009314,GO:0009628,GO:0050896	2.6.99.2	ko:K03474,ko:K03584	ko00750,ko01100,ko03440,map00750,map01100,map03440	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	RecO_C,RecO_N
HKD1_k127_1661516_5	1329516.JPST01000035_gene3155	2.681e-84	289.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,27BCC@186824|Thermoactinomycetaceae	91061|Bacilli	S	KH domain	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD1_k127_1661516_8	1232410.KI421421_gene3665	2.105e-47	183.0	COG0739@1|root,COG0739@2|Bacteria,1MY2X@1224|Proteobacteria,42U06@68525|delta/epsilon subdivisions,2X9QY@28221|Deltaproteobacteria,43VFG@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_1661516_11	177437.HRM2_35790	1.822e-28	121.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,42UZ6@68525|delta/epsilon subdivisions,2WQDM@28221|Deltaproteobacteria,2MPVA@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Uncharacterized protein family UPF0054	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD1_k127_1661516_3	671143.DAMO_2990	4.045e-145	477.0	COG1480@1|root,COG1480@2|Bacteria,2NP1K@2323|unclassified Bacteria	2|Bacteria	S	7TM receptor with intracellular HD hydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
HKD1_k127_1661516_4	671143.DAMO_2989	2.923e-135	438.0	COG1702@1|root,COG1702@2|Bacteria,2NNZF@2323|unclassified Bacteria	2|Bacteria	T	PhoH-like protein	phoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD1_k127_1661516_6	1232410.KI421413_gene478	1.316e-77	276.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,42UYG@68525|delta/epsilon subdivisions,2WR4P@28221|Deltaproteobacteria,43V2Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_1661516_13	234267.Acid_2861	3.503e-23	106.0	COG0457@1|root,COG0457@2|Bacteria,3Y4RD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HKD1_k127_1661516_14	545695.TREAZ_2783	2.107e-06	52.0	COG2204@1|root,COG2204@2|Bacteria,2J6EQ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1666952_0	102125.Xen7305DRAFT_00024090	9.672e-160	516.0	COG2801@1|root,COG2801@2|Bacteria,1G1WB@1117|Cyanobacteria	2|Bacteria	L	PFAM Mu transposase, C-terminal	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_23,HTH_28,Mu-transpos_C,rve
HKD1_k127_1666952_1	102125.Xen7305DRAFT_00024100	1.392e-52	197.0	COG2842@1|root,COG2842@2|Bacteria	2|Bacteria	S	AAA domain	-	-	3.6.1.3	ko:K07132	-	-	-	-	ko00000,ko01000	-	-	-	AAA_22
HKD1_k127_1680518_7	671143.DAMO_1587	1.14e-49	184.0	COG0526@1|root,COG0526@2|Bacteria,2NPYK@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin-like	dsbE	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
HKD1_k127_1680518_6	247490.KSU1_C1034	4.088e-53	196.0	COG3861@1|root,COG3861@2|Bacteria,2IZRE@203682|Planctomycetes	203682|Planctomycetes	S	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_1680518_10	1121405.dsmv_2351	4.889e-40	152.0	2CNK3@1|root,32SH9@2|Bacteria,1N02U@1224|Proteobacteria,42V96@68525|delta/epsilon subdivisions,2WRGH@28221|Deltaproteobacteria,2MNZE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of Unknown function (DUF2784)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2784
HKD1_k127_1680518_13	671143.DAMO_2368	5.865e-25	114.0	COG3678@1|root,COG3678@2|Bacteria,2NRWA@2323|unclassified Bacteria	2|Bacteria	NPTU	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HKD1_k127_1680518_9	1125863.JAFN01000001_gene1473	2.44e-41	162.0	COG3439@1|root,COG3439@2|Bacteria,1RH9Z@1224|Proteobacteria,42VVC@68525|delta/epsilon subdivisions,2WRH9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD1_k127_1680518_15	1125863.JAFN01000001_gene2235	5.18e-13	72.0	COG3462@1|root,COG3462@2|Bacteria	2|Bacteria	S	membrane protein (DUF2078)	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HKD1_k127_1680518_11	1094980.Mpsy_1432	8.618e-37	146.0	COG2010@1|root,arCOG06111@2157|Archaea,2XXGW@28890|Euryarchaeota	28890|Euryarchaeota	C	Cytochrome c	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_1680518_2	880072.Desac_0720	2.755e-143	469.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1680518_5	404589.Anae109_0620	1.391e-57	218.0	COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42RPW@68525|delta/epsilon subdivisions,2WK10@28221|Deltaproteobacteria,2Z2WV@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,dCache_2
HKD1_k127_1680518_8	869210.Marky_1416	3.739e-43	163.0	2CP7W@1|root,32MRP@2|Bacteria,1WKBJ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1680518_3	671143.DAMO_0822	2.775e-134	453.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD1_k127_1680518_1	671143.DAMO_0821	3.397e-170	541.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HKD1_k127_1680518_4	671143.DAMO_0820	6.172e-59	207.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HKD1_k127_1680518_0	663610.JQKO01000008_gene56	0.0	1067.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,3NAW2@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	YHS domain	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD1_k127_1680518_16	158500.BV97_03066	5.997e-13	70.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales	204457|Sphingomonadales	P	P-type ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HKD1_k127_1680518_12	1094980.Mpsy_1432	6.36e-33	142.0	COG2010@1|root,arCOG06111@2157|Archaea,2XXGW@28890|Euryarchaeota	28890|Euryarchaeota	C	Cytochrome c	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_1680518_14	671143.DAMO_2368	4.366e-20	103.0	COG3678@1|root,COG3678@2|Bacteria,2NRWA@2323|unclassified Bacteria	2|Bacteria	NPTU	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	Metal_resist
HKD1_k127_1690176_6	645991.Sgly_0856	4.226e-24	109.0	COG0644@1|root,COG0644@2|Bacteria,1TRTQ@1239|Firmicutes,24E1W@186801|Clostridia,261F2@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM geranylgeranyl reductase family	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
HKD1_k127_1690176_0	266117.Rxyl_3113	1.063e-105	355.0	COG1087@1|root,COG1087@2|Bacteria,2GMCW@201174|Actinobacteria,4CU6C@84995|Rubrobacteria	84995|Rubrobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD1_k127_1690176_4	1499967.BAYZ01000147_gene687	2.858e-30	138.0	2EDIX@1|root,337ET@2|Bacteria	2|Bacteria	S	tagaturonate epimerase	-	-	-	-	-	-	-	-	-	-	-	-	UxaE
HKD1_k127_1690176_2	573061.Clocel_1755	2.315e-74	256.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,36I7J@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD1_k127_1690176_3	1123024.AUII01000001_gene2941	8.59e-54	191.0	COG0251@1|root,COG0251@2|Bacteria,2IIXG@201174|Actinobacteria,4EAYK@85010|Pseudonocardiales	201174|Actinobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_1690176_7	398525.KB900701_gene3037	1.166e-22	100.0	COG0517@1|root,COG0517@2|Bacteria,1MXI6@1224|Proteobacteria,2TS6X@28211|Alphaproteobacteria,3JWIG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp,Zn_Tnp_IS91
HKD1_k127_1690176_8	1384065.JAGS01000001_gene987	4.328e-05	51.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia,3WK48@541000|Ruminococcaceae	186801|Clostridia	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD1_k127_1690176_5	192952.MM_1524	4.573e-27	115.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,2N9R7@224756|Methanomicrobia	224756|Methanomicrobia	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
HKD1_k127_1690176_1	553973.CLOHYLEM_05158	3.7e-86	296.0	COG1679@1|root,COG1679@2|Bacteria,1UJDG@1239|Firmicutes,24DTH@186801|Clostridia,21ZZC@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
HKD1_k127_1693911_6	383372.Rcas_0103	3.186e-45	171.0	COG1070@1|root,COG1070@2|Bacteria,2G7KS@200795|Chloroflexi	200795|Chloroflexi	G	FGGY family of carbohydrate kinases, N-terminal domain	-	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_1693911_5	477974.Daud_2175	8.733e-54	201.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,248B7@186801|Clostridia,260W6@186807|Peptococcaceae	186801|Clostridia	G	Fructose-1,6-bisphosphate aldolase, class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_1693911_0	670292.JH26_17160	6.416e-103	344.0	COG4221@1|root,COG4221@2|Bacteria,1R83E@1224|Proteobacteria,2TVY6@28211|Alphaproteobacteria,1JU09@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_1693911_7	331869.BAL199_23067	9.522e-28	114.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,2UBQF@28211|Alphaproteobacteria,4BSRA@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HKD1_k127_1693911_8	1047013.AQSP01000070_gene35	1.461e-15	82.0	COG3093@1|root,COG3093@2|Bacteria	2|Bacteria	K	addiction module antidote protein HigA	vapL	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3,HTH_31
HKD1_k127_1693911_2	573064.Mefer_1000	2.598e-89	315.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,23Q61@183939|Methanococci	183939|Methanococci	E	TIGRFAM argininosuccinate lyase	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_1693911_3	1118054.CAGW01000056_gene2104	5.379e-80	284.0	COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,4HEZJ@91061|Bacilli,26VHQ@186822|Paenibacillaceae	91061|Bacilli	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_1693911_1	1144310.PMI07_006175	2.335e-94	326.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TQJC@28211|Alphaproteobacteria,4BBIF@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_1693911_4	1054213.HMPREF9946_01101	1.396e-78	286.0	COG1173@1|root,COG1173@2|Bacteria,1MVHY@1224|Proteobacteria,2TQVQ@28211|Alphaproteobacteria,2JQEY@204441|Rhodospirillales	204441|Rhodospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_1716059_2	234267.Acid_0827	8.104e-67	238.0	COG1108@1|root,COG1108@2|Bacteria,3Y93X@57723|Acidobacteria	57723|Acidobacteria	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HKD1_k127_1716059_1	1379698.RBG1_1C00001G0108	2.876e-70	248.0	COG0803@1|root,COG0803@2|Bacteria,2NPH3@2323|unclassified Bacteria	2|Bacteria	P	Belongs to the bacterial solute-binding protein 9 family	znuA	-	-	ko:K02077,ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_1716059_3	349124.Hhal_0489	1.31e-14	86.0	COG3746@1|root,COG3746@2|Bacteria,1MY3M@1224|Proteobacteria,1RZ3M@1236|Gammaproteobacteria,1WWSF@135613|Chromatiales	135613|Chromatiales	P	phosphate-selective porin O and P	-	-	-	-	-	-	-	-	-	-	-	-	TonB_dep_Rec
HKD1_k127_1716059_0	456442.Mboo_0351	7.178e-122	414.0	COG3410@1|root,arCOG04708@2157|Archaea	2157|Archaea	S	conserved protein (DUF2075)	-	-	-	ko:K09384	-	-	-	-	ko00000	-	-	-	DUF2075
HKD1_k127_178576_0	880072.Desac_2381	1.594e-107	374.0	COG3087@1|root,COG3087@2|Bacteria,1QUVJ@1224|Proteobacteria	1224|Proteobacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_178576_1	1267534.KB906760_gene1239	1.444e-101	344.0	COG4325@1|root,COG4325@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD1_k127_1793573_23	1283300.ATXB01000001_gene80	4.103e-07	60.0	COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1XF4P@135618|Methylococcales	135618|Methylococcales	NU	Type IV Pilus-assembly protein W	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
HKD1_k127_1793573_22	382464.ABSI01000013_gene1773	1.119e-13	84.0	COG4726@1|root,COG4726@2|Bacteria,46T3V@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1793573_14	671143.DAMO_1464	1.906e-75	262.0	COG2071@1|root,COG2071@2|Bacteria,2NPQK@2323|unclassified Bacteria	2|Bacteria	S	Peptidase C26	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD1_k127_1793573_12	671143.DAMO_1462	4.046e-89	301.0	COG4821@1|root,COG4821@2|Bacteria,2NR6C@2323|unclassified Bacteria	2|Bacteria	S	SIS domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
HKD1_k127_1793573_10	671143.DAMO_1461	2.731e-121	401.0	COG2377@1|root,COG2377@2|Bacteria,2NNMN@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling	anmK	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0044237	2.7.1.170,4.2.1.126	ko:K07106,ko:K09001	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c18930,iECED1_1282.ECED1_1841,ic_1306.c2032	AnmK
HKD1_k127_1793573_8	671143.DAMO_1458	7.055e-132	431.0	COG1473@1|root,COG1473@2|Bacteria,2NP7P@2323|unclassified Bacteria	2|Bacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_1793573_21	880072.Desac_2179	2.736e-15	85.0	COG0468@1|root,COG0468@2|Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	AAA_12,AAA_24,AAA_25,DUF4011
HKD1_k127_1793573_20	880072.Desac_2172	2.906e-20	93.0	arCOG07300@1|root,2ZTGG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1793573_11	204669.Acid345_0620	4.092e-96	328.0	COG1533@1|root,COG1533@2|Bacteria,3Y2S5@57723|Acidobacteria,2JIC8@204432|Acidobacteriia	204432|Acidobacteriia	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_1793573_15	331678.Cphamn1_0755	4.965e-68	239.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00609	R10404	RC00003	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD1_k127_1793573_9	1295642.H839_10673	3.216e-131	426.0	COG0388@1|root,COG0388@2|Bacteria,1TQR9@1239|Firmicutes,4HDUI@91061|Bacilli,1WEZK@129337|Geobacillus	91061|Bacilli	S	Carbon-nitrogen hydrolase	-	-	3.5.5.1	ko:K01501	ko00380,ko00460,ko00627,ko00643,ko00910,ko01120,map00380,map00460,map00627,map00643,map00910,map01120	-	R00540,R01887,R03093,R03542,R05591,R07855	RC00315,RC00325,RC00617,RC00959,RC02811	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD1_k127_1793573_5	489825.LYNGBM3L_24700	3.378e-165	526.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria,1HHPF@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Cys Met metabolism PLP-dependent enzyme	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD1_k127_1793573_16	398767.Glov_0611	9.166e-66	228.0	COG1803@1|root,COG1803@2|Bacteria,1RD3D@1224|Proteobacteria,42SPC@68525|delta/epsilon subdivisions,2WP55@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	TIGRFAM Methylglyoxal synthase	mgsA	-	4.2.3.3	ko:K01734	ko00640,ko01120,map00640,map01120	-	R01016	RC00424	ko00000,ko00001,ko01000	-	-	-	MGS
HKD1_k127_1793573_17	1173024.KI912149_gene5746	5.412e-65	231.0	COG0546@1|root,COG0546@2|Bacteria,1G0NB@1117|Cyanobacteria,1JHEB@1189|Stigonemataceae	1117|Cyanobacteria	S	Haloacid dehalogenase-like hydrolase	gvpK	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD1_k127_1793573_19	997346.HMPREF9374_3285	1.368e-23	109.0	COG0546@1|root,COG0546@2|Bacteria,1V1K2@1239|Firmicutes,4HGEI@91061|Bacilli	91061|Bacilli	K	haloacid dehalogenase-like hydrolase	-	-	3.6.1.1	ko:K06019	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_1793573_13	1380394.JADL01000013_gene703	2.881e-87	299.0	COG0667@1|root,COG0667@2|Bacteria,1R5BH@1224|Proteobacteria,2TS0A@28211|Alphaproteobacteria,2JVHZ@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_1793573_4	880072.Desac_2171	2.755e-173	570.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
HKD1_k127_1793573_6	243231.GSU0479	6.53e-164	528.0	COG1027@1|root,COG1027@2|Bacteria,1R9JY@1224|Proteobacteria,42MFS@68525|delta/epsilon subdivisions,2X6YF@28221|Deltaproteobacteria,43TQ6@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Fumarase C C-terminus	aspA	-	4.3.1.1	ko:K01744	ko00250,ko01100,map00250,map01100	-	R00490	RC00316,RC02799	ko00000,ko00001,ko01000	-	-	-	FumaraseC_C,Lyase_1,cNMP_binding
HKD1_k127_1793573_1	671143.DAMO_0393	6.097e-258	815.0	COG0507@1|root,COG0507@2|Bacteria,2NNQY@2323|unclassified Bacteria	2|Bacteria	L	Helix-hairpin-helix containing domain	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HKD1_k127_1793573_18	330214.NIDE2482	4.35e-29	120.0	COG2146@1|root,COG2146@2|Bacteria,3J1E7@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	1.7.1.15	ko:K00363,ko:K05710	ko00360,ko00910,ko01120,ko01220,map00360,map00910,map01120,map01220	M00530,M00545	R00787,R06782,R06783	RC00098,RC00176	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske
HKD1_k127_1793573_7	1125863.JAFN01000001_gene2148	9.458e-137	449.0	COG1180@1|root,COG1180@2|Bacteria,1QW1I@1224|Proteobacteria,43BRG@68525|delta/epsilon subdivisions,2X72A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_1793573_0	1267535.KB906767_gene2350	9.626e-271	845.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_1793573_2	1125863.JAFN01000001_gene231	3.27e-186	586.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,42MKX@68525|delta/epsilon subdivisions,2WJ7X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iAF987.Gmet_2853	Aminotran_4
HKD1_k127_1793573_3	526227.Mesil_2127	2.701e-176	562.0	COG1048@1|root,COG1048@2|Bacteria,1WIMG@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acn	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003730,GO:0003824,GO:0003994,GO:0005488,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0045333,GO:0046459,GO:0047456,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0072350,GO:0097159,GO:1901363	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_1803860_1	1382306.JNIM01000001_gene3130	1.079e-130	423.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi	2|Bacteria	H	Thiamine pyrophosphate protein TPP binding domain protein	ilvB2	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_1803860_0	991905.SL003B_2525	3.173e-205	655.0	COG1053@1|root,COG1053@2|Bacteria,1MURY@1224|Proteobacteria,2TSRQ@28211|Alphaproteobacteria,4BRHP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2
HKD1_k127_1803860_2	1382306.JNIM01000001_gene3131	0.0004827	43.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Haem_oxygenas_2
HKD1_k127_1812438_3	525904.Tter_1910	7.557e-23	105.0	COG1082@1|root,COG1082@2|Bacteria,2NQZX@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD1_k127_1812438_0	330084.JNYZ01000008_gene6550	8.23e-115	384.0	COG0399@1|root,COG0399@2|Bacteria,2GKD7@201174|Actinobacteria,4E12P@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the DegT DnrJ EryC1 family	rifK	-	4.2.1.144	ko:K16016	ko01051,ko01130,map01051,map01130	-	R06586,R06595	RC00006,RC00781,RC02678	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_1812438_2	525904.Tter_2475	1.694e-44	175.0	COG1609@1|root,COG1609@2|Bacteria,2NR26@2323|unclassified Bacteria	2|Bacteria	K	Periplasmic binding protein LacI transcriptional regulator	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD1_k127_1812438_1	357808.RoseRS_1361	3.507e-61	219.0	COG2017@1|root,COG2017@2|Bacteria,2G7BC@200795|Chloroflexi	200795|Chloroflexi	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	DUF5107
HKD1_k127_190416_7	497964.CfE428DRAFT_4070	1.978e-38	149.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_190416_2	1499967.BAYZ01000069_gene1876	2.188e-114	383.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27,2.7.7.91	ko:K00975,ko:K20427	ko00500,ko00520,ko00525,ko01100,ko01110,ko01130,ko02026,map00500,map00520,map00525,map01100,map01110,map01130,map02026	M00565,M00814	R00948,R11237,R11246,R11402	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_190416_1	1499967.BAYZ01000068_gene1973	2.548e-132	438.0	COG0448@1|root,COG0448@2|Bacteria,2NPBS@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27,2.7.7.91	ko:K00975,ko:K20427	ko00500,ko00520,ko00525,ko01100,ko01110,ko01130,ko02026,map00500,map00520,map00525,map01100,map01110,map01130,map02026	M00565,M00814	R00948,R11237,R11246,R11402	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD1_k127_190416_3	1303518.CCALI_02196	8.354e-109	363.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria	2|Bacteria	S	cellular manganese ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
HKD1_k127_190416_6	395961.Cyan7425_4301	1.435e-45	181.0	COG2202@1|root,COG2203@1|root,COG3437@1|root,COG3829@1|root,COG3920@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,COG3829@2|Bacteria,COG3920@2|Bacteria,1GHCI@1117|Cyanobacteria,3KKV1@43988|Cyanothece	1117|Cyanobacteria	T	SMART PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA_2,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_190416_4	671143.DAMO_1830	1.769e-100	355.0	COG0745@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nifL	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
HKD1_k127_190416_0	671143.DAMO_2495	9.398e-208	663.0	COG1132@1|root,COG1132@2|Bacteria,2NNN4@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter transmembrane region	mdlA	-	-	ko:K06147,ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_190416_5	671143.DAMO_2494	5.911e-95	328.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1916060_4	215803.DB30_6830	4.083e-42	156.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_1916060_3	439235.Dalk_1854	3.947e-56	202.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MIG4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HKD1_k127_1916060_0	439235.Dalk_1854	0.0	1147.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,1MW3N@1224|Proteobacteria,43BJY@68525|delta/epsilon subdivisions,2WIWD@28221|Deltaproteobacteria,2MIG4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	fdnG	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HKD1_k127_1916060_2	439235.Dalk_1855	1.48e-84	287.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42NS2@68525|delta/epsilon subdivisions,2WMA0@28221|Deltaproteobacteria,2MN9Z@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	fdnH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,NrfD
HKD1_k127_1916060_1	439235.Dalk_1856	2.704e-106	359.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,42P2Q@68525|delta/epsilon subdivisions,2WKC2@28221|Deltaproteobacteria,2MJCP@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Polysulphide reductase, NrfD	fdnI	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1061	NrfD
HKD1_k127_1920005_2	1079460.ATTQ01000013_gene2759	1.496e-114	375.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2TX7J@28211|Alphaproteobacteria,4BC0Z@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_1920005_0	1232410.KI421426_gene1474	7.971e-156	512.0	COG3264@1|root,COG3264@2|Bacteria,1QUDC@1224|Proteobacteria,43DHA@68525|delta/epsilon subdivisions,2X8P3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_1920005_3	1193181.BN10_560013	1.987e-10	65.0	COG2161@1|root,COG2161@2|Bacteria,2GV08@201174|Actinobacteria	201174|Actinobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	relB	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007,GO:0097351	-	ko:K19159	-	-	-	-	ko00000,ko02048	-	-	-	PhdYeFM_antitox
HKD1_k127_1920005_4	90814.KL370891_gene905	2.145e-06	53.0	COG2026@1|root,COG2026@2|Bacteria,1NGC6@1224|Proteobacteria	1224|Proteobacteria	DJ	cytotoxic translational repressor of toxin-antitoxin	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_1920005_1	671143.DAMO_1578	1.208e-138	451.0	COG1060@1|root,COG1060@2|Bacteria,2NP8W@2323|unclassified Bacteria	2|Bacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_1926532_12	573370.DMR_33550	3.163e-25	105.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2M9H9@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Carboxylyase-related protein	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_1926532_23	65393.PCC7424_2626	1.661e-05	47.0	COG0457@1|root,COG0457@2|Bacteria,1GA4G@1117|Cyanobacteria,3KICY@43988|Cyanothece	1117|Cyanobacteria	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_6,TPR_8
HKD1_k127_1926532_2	78245.Xaut_3736	7.535e-63	224.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3F1JR@335928|Xanthobacteraceae	28211|Alphaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD1_k127_1926532_14	1120792.JAFV01000001_gene1908	1.2e-16	85.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBQE@28211|Alphaproteobacteria,36YY4@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Helix-turn-helix domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD1_k127_1926532_7	933262.AXAM01000070_gene2294	2.908e-42	164.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_1926532_21	1096546.WYO_2760	4.819e-07	59.0	COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1RCYA@1224|Proteobacteria,2TU8R@28211|Alphaproteobacteria,1JR0K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Cupin 2 conserved barrel domain protein	MA20_09770	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3,HTH_31
HKD1_k127_1926532_5	189753.AXAS01000012_gene4337	4.01e-61	226.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_1926532_19	118161.KB235917_gene133	2.48e-09	62.0	COG1961@1|root,COG1961@2|Bacteria,1G67F@1117|Cyanobacteria,3VKKE@52604|Pleurocapsales	1117|Cyanobacteria	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
HKD1_k127_1926532_15	204669.Acid345_4263	4.16e-16	91.0	COG1961@1|root,COG1961@2|Bacteria,3Y5HT@57723|Acidobacteria,2JK3G@204432|Acidobacteriia	204432|Acidobacteriia	L	Resolvase, N terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_7,Resolvase
HKD1_k127_1926532_8	396588.Tgr7_3139	1.195e-34	150.0	COG5295@1|root,COG5295@2|Bacteria,1N8QZ@1224|Proteobacteria	1224|Proteobacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1926532_22	1358423.N180_02820	8.675e-07	60.0	2E8S0@1|root,3332X@2|Bacteria,4NWIA@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1926532_6	1499967.BAYZ01000033_gene1106	8.807e-52	192.0	COG3382@1|root,COG3382@2|Bacteria	2|Bacteria	J	B3 4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B3_4
HKD1_k127_1926532_16	504728.K649_02050	4.211e-16	88.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	ypeA	-	-	ko:K03826	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD1_k127_1926532_0	420662.Mpe_A0408	5.806e-98	327.0	COG3971@1|root,COG3971@2|Bacteria,1RGHI@1224|Proteobacteria,2VRTF@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	2-Keto-4-pentenoate hydratase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_1926532_13	84531.JMTZ01000025_gene4100	1.068e-16	89.0	2E69S@1|root,330XP@2|Bacteria,1N7XM@1224|Proteobacteria,1SDDI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HKD1_k127_1926532_10	441620.Mpop_1704	9.712e-32	135.0	2DMF8@1|root,32R47@2|Bacteria,1RJ0J@1224|Proteobacteria,2UFI8@28211|Alphaproteobacteria,1JUPT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HKD1_k127_1926532_1	99598.Cal7507_0195	8.454e-81	280.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1HM2J@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD1_k127_1926532_9	391612.CY0110_23281	8.365e-34	149.0	2DTH0@1|root,33KAH@2|Bacteria,1GM3T@1117|Cyanobacteria,3KJ5A@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1926532_11	290397.Adeh_2234	5.336e-26	115.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,42Y44@68525|delta/epsilon subdivisions,2WT88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1988920_1	1347392.CCEZ01000044_gene662	1.084e-105	359.0	COG4091@1|root,COG4091@2|Bacteria,1TR51@1239|Firmicutes,24AUF@186801|Clostridia,36H66@31979|Clostridiaceae	186801|Clostridia	E	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DapB_N,NAD_binding_3,SAF
HKD1_k127_1988920_5	234267.Acid_0972	1.285e-26	118.0	COG1708@1|root,COG1708@2|Bacteria,3Y7NX@57723|Acidobacteria	57723|Acidobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1988920_3	944481.JAFP01000001_gene787	4.727e-35	148.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria,2M6TA@213113|Desulfurellales	28221|Deltaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_1988920_2	56780.SYN_00535	3.024e-63	222.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,42R4C@68525|delta/epsilon subdivisions,2WKG9@28221|Deltaproteobacteria,2MS0Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_1988920_0	667014.Thein_1592	1.478e-236	748.0	COG0441@1|root,COG0441@2|Bacteria,2GH53@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
HKD1_k127_1988920_4	671143.DAMO_1864	2.156e-31	126.0	COG0290@1|root,COG0290@2|Bacteria,2NPDH@2323|unclassified Bacteria	2|Bacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0000049,GO:0001731,GO:0002181,GO:0002183,GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006413,GO:0006417,GO:0006446,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009409,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0016020,GO:0016043,GO:0019222,GO:0019538,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032268,GO:0032270,GO:0032790,GO:0032984,GO:0032988,GO:0032991,GO:0034248,GO:0034250,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043022,GO:0043024,GO:0043043,GO:0043170,GO:0043254,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045727,GO:0045948,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065003,GO:0065007,GO:0070992,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901193,GO:1901195,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008,GO:1904688,GO:1904690,GO:1990856,GO:1990904,GO:2000112,GO:2000765,GO:2000767	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD1_k127_2017897_7	1121472.AQWN01000006_gene1788	8.093e-108	364.0	COG0543@1|root,COG0543@2|Bacteria,1TQBZ@1239|Firmicutes,248GQ@186801|Clostridia,2676A@186807|Peptococcaceae	186801|Clostridia	C	Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulphur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD1_k127_2017897_15	767817.Desgi_2043	6.318e-80	285.0	COG1143@1|root,COG1143@2|Bacteria,1UJ43@1239|Firmicutes,25EVE@186801|Clostridia,2605I@186807|Peptococcaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
HKD1_k127_2017897_14	760568.Desku_1432	1.191e-81	282.0	COG4656@1|root,COG4656@2|Bacteria,1UIC8@1239|Firmicutes,25EHB@186801|Clostridia,267BW@186807|Peptococcaceae	186801|Clostridia	C	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17,Fer4_8,FrhB_FdhB_C
HKD1_k127_2017897_20	697281.Mahau_0896	1.721e-56	201.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,42GG4@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	FlpD
HKD1_k127_2017897_1	1449126.JQKL01000012_gene3470	1.64e-288	899.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Fer4,Fer4_7,Pyr_redox_2
HKD1_k127_2017897_3	1121430.JMLG01000005_gene675	5.405e-232	730.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,264B9@186807|Peptococcaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein	-	-	1.3.5.1,1.3.5.4,1.3.99.33	ko:K00239,ko:K00244,ko:K17363	ko00020,ko00190,ko00340,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00340,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164,R10330	RC00045,RC00669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind,FMN_red
HKD1_k127_2017897_11	760568.Desku_1500	2.176e-99	330.0	COG1152@1|root,COG1152@2|Bacteria,1UKJG@1239|Firmicutes,25FYP@186801|Clostridia,26446@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4,Fer4_10,Fer4_9
HKD1_k127_2017897_12	1125863.JAFN01000001_gene1783	8.214e-93	314.0	COG2048@1|root,COG2048@2|Bacteria,1N37J@1224|Proteobacteria,42P51@68525|delta/epsilon subdivisions,2X6MI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HKD1_k127_2017897_25	1125863.JAFN01000001_gene1784	5.882e-33	132.0	COG1150@1|root,COG1150@2|Bacteria,1NFJN@1224|Proteobacteria,43B2A@68525|delta/epsilon subdivisions,2X6GB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_17
HKD1_k127_2017897_19	1288494.EBAPG3_27310	6.788e-64	237.0	COG5002@1|root,COG5002@2|Bacteria,1PUWJ@1224|Proteobacteria,2WAYZ@28216|Betaproteobacteria,371RM@32003|Nitrosomonadales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD1_k127_2017897_26	880072.Desac_0830	9.26e-14	79.0	COG0745@1|root,COG0745@2|Bacteria,1PGXZ@1224|Proteobacteria,437JJ@68525|delta/epsilon subdivisions,2X2TK@28221|Deltaproteobacteria,2MSE0@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_2017897_18	671143.DAMO_0610	2.016e-68	241.0	COG0494@1|root,COG0494@2|Bacteria,2NPTC@2323|unclassified Bacteria	2|Bacteria	L	NUDIX domain	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_2017897_21	269799.Gmet_3073	1.386e-47	180.0	COG3222@1|root,COG3222@2|Bacteria,1RHCP@1224|Proteobacteria,43B9I@68525|delta/epsilon subdivisions,2X6NN@28221|Deltaproteobacteria,43SK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Guanylyl transferase CofC like	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HKD1_k127_2017897_16	671143.DAMO_0614	9.968e-80	277.0	COG1215@1|root,COG1215@2|Bacteria,2NRME@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_2017897_17	671143.DAMO_0611	9.926e-69	253.0	COG1216@1|root,COG1216@2|Bacteria,2NRAF@2323|unclassified Bacteria	2|Bacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD1_k127_2017897_10	290397.Adeh_1892	5.474e-101	334.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,43BC6@68525|delta/epsilon subdivisions,2X255@28221|Deltaproteobacteria,2YY92@29|Myxococcales	28221|Deltaproteobacteria	C	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD1_k127_2017897_5	671143.DAMO_0612	1.33e-124	411.0	COG0535@1|root,COG0535@2|Bacteria,2NR6I@2323|unclassified Bacteria	2|Bacteria	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD1_k127_2017897_8	426117.M446_6115	8.901e-102	342.0	COG0535@1|root,COG0535@2|Bacteria,1PKRS@1224|Proteobacteria,2UZDC@28211|Alphaproteobacteria,1JU6F@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_2017897_23	671143.DAMO_0620	1.439e-42	162.0	2EA1Q@1|root,33470@2|Bacteria	2|Bacteria	-	-	-	-	1.8.5.2	ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxD
HKD1_k127_2017897_22	269799.Gmet_0018	8.89e-43	174.0	COG2206@1|root,COG3850@1|root,COG2206@2|Bacteria,COG3850@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2WP5V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HD,HD_5
HKD1_k127_2017897_13	479434.Sthe_2934	1.75e-88	309.0	COG1252@1|root,COG1252@2|Bacteria,2G5SS@200795|Chloroflexi,27Y53@189775|Thermomicrobia	189775|Thermomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_2017897_27	889378.Spiaf_1719	2.914e-08	65.0	COG0457@1|root,COG0457@2|Bacteria,2JAI6@203691|Spirochaetes	203691|Spirochaetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2017897_24	370438.PTH_0128	1.314e-34	143.0	COG1216@1|root,COG1216@2|Bacteria,1UJRW@1239|Firmicutes,25F86@186801|Clostridia,262I4@186807|Peptococcaceae	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_2017897_4	211165.AJLN01000061_gene3947	4.821e-134	438.0	COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria,1JK2A@1189|Stigonemataceae	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_2017897_2	861299.J421_1872	5.796e-253	794.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
HKD1_k127_2017897_9	251229.Chro_3613	5.191e-101	336.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_2017897_0	671143.DAMO_0621	0.0	1315.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HKD1_k127_2017897_6	1173028.ANKO01000084_gene946	4.796e-114	374.0	COG1028@1|root,COG1028@2|Bacteria,1G0IE@1117|Cyanobacteria,1H74G@1150|Oscillatoriales	1117|Cyanobacteria	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
HKD1_k127_2021757_7	1123487.KB892838_gene3924	8.751e-36	143.0	COG2239@1|root,COG2239@2|Bacteria,1RFCV@1224|Proteobacteria	1224|Proteobacteria	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
HKD1_k127_2021757_5	1424334.W822_01775	2.55e-75	261.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2VIJM@28216|Betaproteobacteria,3T5HA@506|Alcaligenaceae	28216|Betaproteobacteria	S	Carbon-nitrogen hydrolase	-	-	3.5.1.77	ko:K01459	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD1_k127_2021757_6	1499967.BAYZ01000095_gene4292	1.08e-68	246.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73	ko:K00852,ko:K00856,ko:K10710,ko:K22026	ko00030,ko00230,ko00240,ko01100,map00030,map00230,map00240,map01100	-	R00185,R00513,R01051,R01131,R01228,R02750,R08124	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_2021757_8	290317.Cpha266_1382	4.039e-14	76.0	COG1569@1|root,COG1569@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HKD1_k127_2021757_2	1121920.AUAU01000002_gene2033	1.663e-132	433.0	COG0013@1|root,COG0013@2|Bacteria,3Y4AR@57723|Acidobacteria	57723|Acidobacteria	J	Threonyl and Alanyl tRNA synthetase second additional domain	-	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_2021757_1	452637.Oter_4342	2.169e-133	437.0	COG1312@1|root,COG1312@2|Bacteria,46UDP@74201|Verrucomicrobia,3K8B6@414999|Opitutae	414999|Opitutae	G	Catalyzes the dehydration of D-mannonate	-	-	4.2.1.8	ko:K01686	ko00040,ko01100,map00040,map01100	M00061	R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	UxuA
HKD1_k127_2021757_0	1267535.KB906767_gene265	1.502e-154	505.0	COG0443@1|root,COG0443@2|Bacteria	2|Bacteria	O	unfolded protein binding	hscA	-	-	-	-	-	-	-	-	-	-	-	HSP70,RNase_Zc3h12a
HKD1_k127_2021757_4	1499967.BAYZ01000028_gene1246	5.136e-88	299.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_2021757_3	1499967.BAYZ01000028_gene1245	3.51e-104	361.0	COG3734@1|root,COG3734@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
HKD1_k127_2035488_10	883.DvMF_2802	1.142e-15	85.0	COG2823@1|root,COG2823@2|Bacteria,1Q1QW@1224|Proteobacteria,42U7A@68525|delta/epsilon subdivisions,2X5PY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HKD1_k127_2035488_8	330214.NIDE4278	3.059e-63	226.0	2DC00@1|root,2ZC4V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2035488_4	621372.ACIH01000203_gene2423	6.906e-83	290.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,4HA0A@91061|Bacilli,26QBT@186822|Paenibacillaceae	91061|Bacilli	S	Protein containing tetrapyrrole methyltransferase domain and MazG-like	yabN	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
HKD1_k127_2035488_0	1267533.KB906735_gene4926	3.779e-150	499.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
HKD1_k127_2035488_5	292459.STH1114	1.358e-74	260.0	COG1015@1|root,COG1015@2|Bacteria,1UJAM@1239|Firmicutes,25EZP@186801|Clostridia	186801|Clostridia	C	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
HKD1_k127_2035488_1	1379698.RBG1_1C00001G1760	6.611e-124	411.0	COG1030@1|root,COG1030@2|Bacteria,2NNMU@2323|unclassified Bacteria	2|Bacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
HKD1_k127_2035488_2	671143.DAMO_0444	1.559e-120	393.0	COG0330@1|root,COG0330@2|Bacteria,2NNUC@2323|unclassified Bacteria	2|Bacteria	O	prohibitin homologues	hflC	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_2035488_6	69014.TK1161	3.343e-69	246.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y878@28890|Euryarchaeota,245MF@183968|Thermococci	183968|Thermococci	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_2035488_12	706587.Desti_4672	9.953e-09	65.0	2EM0R@1|root,33EQ9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2035488_13	1232437.KL662011_gene1514	7.448e-07	53.0	2EINH@1|root,33CDW@2|Bacteria,1NN5W@1224|Proteobacteria,42XC5@68525|delta/epsilon subdivisions,2WT26@28221|Deltaproteobacteria,2MMA6@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2035488_11	1125863.JAFN01000001_gene2882	4.696e-15	84.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,TPR_16,gag-asp_proteas
HKD1_k127_2035488_9	944479.JQLX01000010_gene571	1.431e-33	135.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,42U0T@68525|delta/epsilon subdivisions,2WQ7I@28221|Deltaproteobacteria,2M76J@213113|Desulfurellales	28221|Deltaproteobacteria	O	CS domain	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_2035488_14	797114.C475_07686	0.0002896	45.0	arCOG02764@1|root,arCOG02764@2157|Archaea,2Y054@28890|Euryarchaeota,23XGI@183963|Halobacteria	183963|Halobacteria	P	Heavy metal transport detoxification protein	-	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
HKD1_k127_2035488_3	243231.GSU0487	2.243e-85	293.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,42MJ0@68525|delta/epsilon subdivisions,2WKKK@28221|Deltaproteobacteria,43SA5@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	dmeF	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD1_k127_2035488_7	1121428.DESHY_150111___1	3.141e-67	247.0	COG0500@1|root,COG1246@1|root,COG1246@2|Bacteria,COG2226@2|Bacteria,1U9KN@1239|Firmicutes	1239|Firmicutes	E	methyltransferase	ywlB	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD1_k127_2036739_1	316067.Geob_0094	3.694e-64	229.0	2C8XG@1|root,2Z7PK@2|Bacteria,1RA5I@1224|Proteobacteria,42QRD@68525|delta/epsilon subdivisions,2WMYW@28221|Deltaproteobacteria,43V3A@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
HKD1_k127_2036739_0	1232437.KL662022_gene879	6.154e-90	309.0	COG0633@1|root,COG3894@1|root,COG0633@2|Bacteria,COG3894@2|Bacteria,1MV6C@1224|Proteobacteria,42MF5@68525|delta/epsilon subdivisions,2WIJD@28221|Deltaproteobacteria,2MHUT@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD1_k127_2045368_2	1195236.CTER_2914	2.383e-108	361.0	COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,24AUV@186801|Clostridia,3WPE2@541000|Ruminococcaceae	186801|Clostridia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_2045368_0	86416.Clopa_4019	8.761e-203	658.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	cutC	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_2045368_1	479434.Sthe_3301	2.872e-130	426.0	COG1804@1|root,COG1804@2|Bacteria,2G7MX@200795|Chloroflexi,27YZQ@189775|Thermomicrobia	189775|Thermomicrobia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_2064382_0	1121875.KB907549_gene2004	2.714e-107	359.0	COG0205@1|root,COG0205@2|Bacteria,4NF8F@976|Bacteroidetes,1HWWG@117743|Flavobacteriia	2|Bacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_2064382_1	748247.AZKH_1973	1.217e-90	302.0	COG1180@1|root,COG1180@2|Bacteria,1QJHU@1224|Proteobacteria,2WFUK@28216|Betaproteobacteria,2KXC6@206389|Rhodocyclales	206389|Rhodocyclales	C	4Fe-4S single cluster domain	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_2072649_22	338966.Ppro_0301	0.0002787	48.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,42M09@68525|delta/epsilon subdivisions,2WJ1G@28221|Deltaproteobacteria,43T4B@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD1_k127_2072649_13	671143.DAMO_2940	2.925e-37	142.0	COG0718@1|root,COG0718@2|Bacteria,2NPUK@2323|unclassified Bacteria	2|Bacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD1_k127_2072649_3	671143.DAMO_2939	2.705e-81	274.0	COG0353@1|root,COG0353@2|Bacteria,2NP5N@2323|unclassified Bacteria	2|Bacteria	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	GO:0000731,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0018130,GO:0019438,GO:0033554,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:1901360,GO:1901362,GO:1901576	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH,RecR,Toprim_4
HKD1_k127_2072649_12	1340493.JNIF01000003_gene1948	2.3e-37	150.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_2072649_0	1449126.JQKL01000003_gene1813	3.99e-141	470.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_2072649_9	525903.Taci_0473	1.212e-43	166.0	COG1142@1|root,COG1142@2|Bacteria,3TB3B@508458|Synergistetes	508458|Synergistetes	C	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_6
HKD1_k127_2072649_5	1121468.AUBR01000010_gene2451	3.181e-75	267.0	COG1251@1|root,COG1251@2|Bacteria,1TQYX@1239|Firmicutes,24AD5@186801|Clostridia,42FHR@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_2072649_16	326427.Cagg_0599	7.357e-23	106.0	COG2199@1|root,COG3706@2|Bacteria,2G8GT@200795|Chloroflexi,374RS@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,Response_reg
HKD1_k127_2072649_8	1196835.A458_01225	2.408e-47	180.0	COG0622@1|root,COG0622@2|Bacteria,1RGUN@1224|Proteobacteria,1S69D@1236|Gammaproteobacteria,1Z0QQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Phosphoesterase	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD1_k127_2072649_14	1121935.AQXX01000127_gene1130	2.401e-32	130.0	COG4319@1|root,COG4319@2|Bacteria,1N8AM@1224|Proteobacteria	1224|Proteobacteria	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_2072649_2	1472716.KBK24_0100315	5.166e-94	316.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2VQ8D@28216|Betaproteobacteria,1K2JR@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2072649_17	485913.Krac_6476	6.562e-14	78.0	COG1506@1|root,COG1506@2|Bacteria,2G5NN@200795|Chloroflexi	2|Bacteria	E	Peptidase S9, prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD1_k127_2072649_18	525897.Dbac_2186	4.588e-10	66.0	2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2072649_19	1415780.JPOG01000001_gene3251	2.223e-09	60.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,1SGD7@1236|Gammaproteobacteria,1X8TY@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD1_k127_2072649_20	504832.OCAR_6947	1.568e-08	56.0	2AEV9@1|root,314SS@2|Bacteria,1NAGH@1224|Proteobacteria,2UJB1@28211|Alphaproteobacteria,3K0X6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3096
HKD1_k127_2072649_6	138119.DSY0970	8.177e-56	211.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2495J@186801|Clostridia,260RY@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD1_k127_2072649_4	1499967.BAYZ01000163_gene6592	1.677e-76	272.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_2072649_1	1499967.BAYZ01000163_gene6591	5.513e-132	433.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_2072649_21	1123366.TH3_19477	2.842e-07	63.0	COG3090@1|root,COG3090@2|Bacteria,1RIQN@1224|Proteobacteria,2UBZ3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_2072649_15	1172186.KB911465_gene4201	1.458e-27	124.0	COG4221@1|root,COG4221@2|Bacteria,2GP17@201174|Actinobacteria,235ND@1762|Mycobacteriaceae	201174|Actinobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_2072649_7	714943.Mucpa_6877	5.883e-49	190.0	COG0382@1|root,COG0382@2|Bacteria	2|Bacteria	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39,2.5.1.42	ko:K03179,ko:K17105	ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110	M00117	R04520,R05000,R05615	RC00209,RC01171,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_2072649_11	1206737.BAGF01000075_gene4763	8.088e-41	166.0	COG1597@1|root,COG1597@2|Bacteria,2HHKU@201174|Actinobacteria,4FZ0T@85025|Nocardiaceae	201174|Actinobacteria	I	Diacylglycerol kinase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD1_k127_2072649_10	714943.Mucpa_6873	3.68e-41	160.0	COG0611@1|root,COG0611@2|Bacteria	2|Bacteria	H	thiamine-phosphate kinase activity	-	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS
HKD1_k127_2074390_5	671143.DAMO_1651	2.315e-101	338.0	COG1044@1|root,COG1044@2|Bacteria,2NNSF@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD1_k127_2074390_15	671143.DAMO_1650	2.598e-60	218.0	COG0764@1|root,COG0764@2|Bacteria,2NPK9@2323|unclassified Bacteria	2|Bacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	3.5.1.108,4.2.1.59	ko:K02372,ko:K16363	ko00061,ko00540,ko00780,ko01100,ko01212,map00061,map00540,map00780,map01100,map01212	M00060,M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965,R07764,R10117,R10121	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA
HKD1_k127_2074390_10	671143.DAMO_1648	8.793e-75	263.0	COG3494@1|root,COG3494@2|Bacteria,2NR94@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF1009)	cdsA2	GO:0003674,GO:0003824,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0008758,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0019637,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748,ko:K09949	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	DUF1009
HKD1_k127_2074390_3	671143.DAMO_1647	9.701e-112	368.0	COG0673@1|root,COG0673@2|Bacteria,2NNUQ@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA
HKD1_k127_2074390_6	671143.DAMO_1646	1.738e-92	318.0	COG0763@1|root,COG0763@2|Bacteria,2NP10@2323|unclassified Bacteria	2|Bacteria	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD1_k127_2074390_11	671143.DAMO_1645	6.004e-73	254.0	COG2121@1|root,COG2121@2|Bacteria,2NPP6@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD1_k127_2074390_2	671143.DAMO_1644	2.07e-112	379.0	COG1519@1|root,COG1519@2|Bacteria,2NP5A@2323|unclassified Bacteria	2|Bacteria	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
HKD1_k127_2074390_12	671143.DAMO_1643	3.484e-72	263.0	COG1663@1|root,COG1663@2|Bacteria,2NPF0@2323|unclassified Bacteria	2|Bacteria	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396	LpxK
HKD1_k127_2074390_9	671143.DAMO_1642	2.893e-78	273.0	COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria	2|Bacteria	M	Lipid A biosynthesis	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD1_k127_2074390_0	330214.NIDE3031	5.52e-125	423.0	COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,3J0PZ@40117|Nitrospirae	40117|Nitrospirae	EM	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9,Hydrolase_like
HKD1_k127_2074390_4	671143.DAMO_1640	1.931e-102	344.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD1_k127_2074390_1	448385.sce7377	8.796e-115	378.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,42MWH@68525|delta/epsilon subdivisions,2WJMZ@28221|Deltaproteobacteria,2Z0DM@29|Myxococcales	28221|Deltaproteobacteria	M	RmlD substrate binding domain	uge	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_2074390_22	1095769.CAHF01000010_gene1177	4.71e-05	53.0	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria,2VSJ5@28216|Betaproteobacteria,474R1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA,Gly-zipper_YMGG
HKD1_k127_2074390_21	261292.Nit79A3_2658	8.49e-17	89.0	2DP14@1|root,3303I@2|Bacteria,1N7JW@1224|Proteobacteria,2VW7N@28216|Betaproteobacteria,373JJ@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2074390_13	696369.KI912183_gene2001	2.636e-71	255.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,2607I@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_2074390_7	1449126.JQKL01000003_gene1756	2.331e-85	294.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,268B4@186813|unclassified Clostridiales	186801|Clostridia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_2074390_16	1499967.BAYZ01000103_gene3781	3.323e-55	204.0	COG1028@1|root,COG1028@2|Bacteria,2NP35@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2074390_14	1298867.AUES01000017_gene3997	1.971e-63	228.0	COG1414@1|root,COG1414@2|Bacteria,1MUNW@1224|Proteobacteria,2TSY8@28211|Alphaproteobacteria,3JTIU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD1_k127_2074390_18	231434.JQJH01000022_gene1465	2.316e-40	161.0	COG1082@1|root,COG1082@2|Bacteria,1N0QZ@1224|Proteobacteria,2UDUZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_2074390_8	1131814.JAFO01000001_gene4681	7.948e-79	274.0	COG0451@1|root,COG0451@2|Bacteria,1R5DG@1224|Proteobacteria,2TWFF@28211|Alphaproteobacteria,3F02Y@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	GDP-mannose 4,6 dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD1_k127_2074390_17	1382306.JNIM01000001_gene3131	2.244e-41	158.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Haem_oxygenas_2
HKD1_k127_2074390_20	644548.SCNU_19035	4.787e-28	118.0	COG1053@1|root,COG1053@2|Bacteria,2GIXG@201174|Actinobacteria,4GD2Q@85026|Gordoniaceae	201174|Actinobacteria	C	FAD dependent oxidoreductase	-	-	1.3.99.4	ko:K05898	ko00984,ko01100,ko01120,map00984,map01100,map01120	-	R09884	RC00991	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2
HKD1_k127_2089871_0	1205680.CAKO01000006_gene3265	4.419e-113	373.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
HKD1_k127_2089871_1	1128427.KB904821_gene3178	4.864e-07	61.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,1HA72@1150|Oscillatoriales	1117|Cyanobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_2091183_0	671143.DAMO_0866	1.662e-220	689.0	COG0493@1|root,COG0493@2|Bacteria,2NNUI@2323|unclassified Bacteria	2|Bacteria	E	Flavin containing amine oxidoreductase	gltD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iJN678.gltD,iNJ661.Rv3858c,iSB619.SA_RS02450	Fer4_20,Pyr_redox_2
HKD1_k127_2092978_0	671143.DAMO_0818	6.384e-109	362.0	COG3005@1|root,COG3005@2|Bacteria,2NQ90@2323|unclassified Bacteria	2|Bacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	ko:K08354	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C554,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1
HKD1_k127_2092978_1	1379698.RBG1_1C00001G0297	5.671e-99	328.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_2094030_0	1347087.CBYO010000007_gene1051	7.869e-78	273.0	COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HCVR@91061|Bacilli	91061|Bacilli	P	ABC transporter, solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD1_k127_2094030_1	330084.JNYZ01000002_gene1659	9.88e-35	135.0	COG2017@1|root,COG2017@2|Bacteria,2IBS3@201174|Actinobacteria	201174|Actinobacteria	G	converts alpha-aldose to the beta-anomer	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2103936_0	485913.Krac_3419	1.026e-72	261.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
HKD1_k127_2132203_0	1283300.ATXB01000001_gene819	2.489e-42	162.0	COG1618@1|root,COG1618@2|Bacteria,1N4XQ@1224|Proteobacteria	1224|Proteobacteria	F	NTPase	-	-	-	-	-	-	-	-	-	-	-	-	NTPase_1
HKD1_k127_2132203_2	228410.NE0846	1.781e-24	109.0	2BH5I@1|root,32B6M@2|Bacteria,1RKHK@1224|Proteobacteria,2VSSI@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD
HKD1_k127_2132203_1	314278.NB231_02148	1.163e-37	158.0	COG1073@1|root,COG1073@2|Bacteria,1R9V1@1224|Proteobacteria,1TIVF@1236|Gammaproteobacteria,1X1GF@135613|Chromatiales	135613|Chromatiales	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2138974_3	671143.DAMO_0750	1.069e-62	218.0	COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria	2|Bacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_2138974_1	671143.DAMO_0751	8.23e-103	346.0	COG0638@1|root,COG0638@2|Bacteria,2NQJR@2323|unclassified Bacteria	2|Bacteria	O	Proteasome subunit	prcB	GO:0000502,GO:0003674,GO:0003824,GO:0004175,GO:0004298,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005839,GO:0005886,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010498,GO:0016020,GO:0016787,GO:0019538,GO:0019774,GO:0019899,GO:0019941,GO:0030163,GO:0032991,GO:0035375,GO:0040007,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0051603,GO:0051704,GO:0070003,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD1_k127_2138974_2	671143.DAMO_0752	4.811e-94	315.0	COG0638@1|root,COG0638@2|Bacteria,2NQRX@2323|unclassified Bacteria	2|Bacteria	O	Proteasome subunit	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD1_k127_2138974_0	671143.DAMO_0753	1.417e-162	528.0	COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria	2|Bacteria	O	Pup-ligase protein	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_2141182_1	189753.AXAS01000041_gene2534	1.963e-21	98.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_2141182_0	189753.AXAS01000041_gene2534	4.14e-86	297.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_2141764_4	370438.PTH_0070	2.684e-60	214.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,260P1@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_2141764_7	1121405.dsmv_1963	4.768e-44	168.0	COG1226@1|root,COG1226@2|Bacteria,1MYKU@1224|Proteobacteria,42SR3@68525|delta/epsilon subdivisions,2WP9S@28221|Deltaproteobacteria,2MK4H@213118|Desulfobacterales	28221|Deltaproteobacteria	P	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)	-	-	-	-	-	-	-	-	-	-	-	-	TrkA_N
HKD1_k127_2141764_5	1123371.ATXH01000019_gene589	1.036e-55	199.0	COG0778@1|root,COG0778@2|Bacteria,2GHTQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_2141764_1	335543.Sfum_0467	6.91e-131	428.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,42NIG@68525|delta/epsilon subdivisions,2WIR1@28221|Deltaproteobacteria,2MQ4I@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_2141764_3	671143.DAMO_2419	1.078e-65	231.0	COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria	2|Bacteria	L	Uracil DNA glycosylase superfamily	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_2141764_0	335543.Sfum_0465	9.448e-132	434.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,2MQRK@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
HKD1_k127_2141764_2	335543.Sfum_0464	2.226e-118	385.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,42NX0@68525|delta/epsilon subdivisions,2WISZ@28221|Deltaproteobacteria,2MQ9P@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_2141764_8	335543.Sfum_0463	7.006e-28	115.0	2ECCP@1|root,336AZ@2|Bacteria,1N9PN@1224|Proteobacteria,42W93@68525|delta/epsilon subdivisions,2WRXB@28221|Deltaproteobacteria,2MS3Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Rho_N
HKD1_k127_2141764_6	439235.Dalk_2746	8.403e-52	190.0	COG2316@1|root,COG2316@2|Bacteria,1RA50@1224|Proteobacteria,42QZZ@68525|delta/epsilon subdivisions,2WMUN@28221|Deltaproteobacteria,2MJHQ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_2159024_1	1121439.dsat_0035	2.448e-121	396.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
HKD1_k127_2159024_2	1121440.AUMA01000009_gene596	1.043e-114	378.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42MKP@68525|delta/epsilon subdivisions,2WJU9@28221|Deltaproteobacteria,2MGDW@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_2159024_3	1121406.JAEX01000003_gene1499	1.325e-110	367.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria,2M91J@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1821	BPD_transp_2
HKD1_k127_2159024_5	404380.Gbem_2186	2.602e-74	264.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions	1224|Proteobacteria	E	ABC transporter	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD1_k127_2159024_4	1121406.JAEX01000003_gene1497	6.915e-95	316.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M5A@68525|delta/epsilon subdivisions,2WK03@28221|Deltaproteobacteria,2M9W9@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_2159024_0	177439.DP1272	4.273e-203	642.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42MSQ@68525|delta/epsilon subdivisions,2WISJ@28221|Deltaproteobacteria,2MPW4@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-1	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_216137_3	1121396.KB893123_gene1084	1.1e-68	267.0	COG2197@1|root,COG2202@1|root,COG4585@1|root,COG2197@2|Bacteria,COG2202@2|Bacteria,COG4585@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HATPase_c,HTH_3,HisKA,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,SBP_bac_3
HKD1_k127_216137_5	65393.PCC7424_0596	2.98e-39	170.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3KGUV@43988|Cyanothece	1117|Cyanobacteria	T	GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,HAMP,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SBP_bac_3,dCache_1
HKD1_k127_216137_2	1449126.JQKL01000042_gene1033	5.187e-70	243.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,269AP@186813|unclassified Clostridiales	186801|Clostridia	T	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_216137_4	479434.Sthe_0156	2.108e-49	198.0	COG3850@1|root,COG3850@2|Bacteria,2GBH4@200795|Chloroflexi,27XF0@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_3
HKD1_k127_216137_8	1345697.M493_12305	0.0001515	55.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,4HANF@91061|Bacilli,1WERY@129337|Geobacillus	91061|Bacilli	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_216137_1	452637.Oter_2137	9.128e-84	287.0	COG2006@1|root,COG2006@2|Bacteria,46U2P@74201|Verrucomicrobia,3K77Y@414999|Opitutae	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_216137_6	525897.Dbac_1575	2.499e-28	118.0	COG1359@1|root,COG1359@2|Bacteria,1RI7W@1224|Proteobacteria,42Y4G@68525|delta/epsilon subdivisions,2WTC4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_216137_0	1265505.ATUG01000001_gene3854	7.683e-178	569.0	COG0427@1|root,COG0427@2|Bacteria,1NVAY@1224|Proteobacteria,42ZS2@68525|delta/epsilon subdivisions,2WUYX@28221|Deltaproteobacteria,2MN92@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_2164258_2	485913.Krac_0261	1.128e-17	86.0	COG3335@1|root,COG3335@2|Bacteria,2G8X3@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Rhodopirellula transposase family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_2164258_1	290317.Cpha266_0332	4.344e-42	159.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_2164258_3	163908.KB235896_gene4765	8.603e-07	53.0	COG3335@1|root,COG3335@2|Bacteria,1G4FA@1117|Cyanobacteria,1HQ3V@1161|Nostocales	1117|Cyanobacteria	L	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_2164258_0	485913.Krac_3929	1.547e-43	174.0	28JEU@1|root,2Z98W@2|Bacteria,2G8M2@200795|Chloroflexi	200795|Chloroflexi	S	PFAM MULE transposase, conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	MULE
HKD1_k127_2173731_0	399795.CtesDRAFT_PD1775	2.51e-60	211.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria,2VXJS@28216|Betaproteobacteria,4AHS5@80864|Comamonadaceae	28216|Betaproteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2179573_0	316067.Geob_0774	1.693e-140	461.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TGP@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Penicillin-binding protein, dimerisation domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD1_k127_2179573_1	335543.Sfum_3463	1.953e-96	329.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,42N5Q@68525|delta/epsilon subdivisions,2WJ8J@28221|Deltaproteobacteria,2MQE3@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_2181938_0	1283300.ATXB01000001_gene385	7.965e-121	428.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XEIK@135618|Methylococcales	135618|Methylococcales	KT	PFAM RNA polymerase sigma factor 54, interaction	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
HKD1_k127_2181938_2	335543.Sfum_1463	1.272e-19	92.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	ycnE	GO:0003674,GO:0003824	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	ABM
HKD1_k127_2181938_1	1089552.KI911559_gene1255	2.387e-35	142.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,2JSUH@204441|Rhodospirillales	204441|Rhodospirillales	M	17 kDa outer membrane surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Rick_17kDa_Anti
HKD1_k127_2181938_3	715226.ABI_20880	0.0001678	53.0	COG5126@1|root,COG5126@2|Bacteria,1NAM6@1224|Proteobacteria,2UH6E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	DTZ	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5,EF-hand_7
HKD1_k127_2188386_3	443598.AUFA01000127_gene7209	3.197e-31	123.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria,3JYZA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_2188386_1	189753.AXAS01000041_gene2534	6.979e-74	262.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_2188386_0	515635.Dtur_1805	1.951e-102	364.0	COG0058@1|root,COG0058@2|Bacteria	2|Bacteria	G	glycogen phosphorylase activity	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_2188386_2	1499967.BAYZ01000055_gene4836	1.144e-72	256.0	COG0488@1|root,COG0488@2|Bacteria,2NNPH@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter	yheS	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_2194479_6	713587.THITH_07045	1.51e-27	114.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,1RMCS@1236|Gammaproteobacteria,1WWP0@135613|Chromatiales	135613|Chromatiales	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_2194479_0	1121405.dsmv_2542	1.713e-179	577.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1MUI0@1224|Proteobacteria,42MCB@68525|delta/epsilon subdivisions,2WIRJ@28221|Deltaproteobacteria,2MISA@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Belongs to the precorrin methyltransferase family	hemD	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD1_k127_2194479_2	1304885.AUEY01000013_gene3121	6.378e-94	318.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2WJ5V@28221|Deltaproteobacteria,2MISN@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD1_k127_2194479_1	671143.DAMO_1079	1.875e-139	454.0	COG0373@1|root,COG0373@2|Bacteria,2NP37@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0005575,GO:0005623,GO:0009288,GO:0042597,GO:0042995,GO:0043226,GO:0043228,GO:0044464,GO:0055040	1.2.1.70	ko:K02407,ko:K02492,ko:K10714	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,ko02040,map00680,map00860,map01100,map01110,map01120,map01200,map02040	M00121	R04109,R08059	RC00055,RC00149,RC00202	ko00000,ko00001,ko00002,ko01000,ko02035	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD1_k127_2194479_4	1232410.KI421412_gene412	1.026e-62	226.0	COG0755@1|root,COG0755@2|Bacteria,1RCCI@1224|Proteobacteria,42PVM@68525|delta/epsilon subdivisions,2WJ7I@28221|Deltaproteobacteria,43SCE@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD1_k127_2194479_5	1121428.DESHY_10149___1	4.738e-46	176.0	COG1648@1|root,COG1648@2|Bacteria,1VA2E@1239|Firmicutes,24N6M@186801|Clostridia,2625C@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM siroheme synthase	cysG	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M
HKD1_k127_2194479_3	671143.DAMO_1078	8.9e-72	244.0	COG1327@1|root,COG1327@2|Bacteria,2NPEU@2323|unclassified Bacteria	2|Bacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_2198757_5	944564.HMPREF9200_1406	1.032e-17	88.0	COG4770@1|root,COG4770@2|Bacteria,1VA1E@1239|Firmicutes,4H5DY@909932|Negativicutes	909932|Negativicutes	I	glutaconyl-CoA decarboxylase subunit gamma	gcdC	-	4.1.1.70	ko:K01615	ko00362,ko00650,ko01120,map00362,map00650,map01120	-	R03028	RC00832	ko00000,ko00001,ko01000,ko02000	3.B.1.1.3	-	-	Biotin_lipoyl
HKD1_k127_2198757_0	383372.Rcas_0953	3.882e-152	488.0	COG1883@1|root,COG1883@2|Bacteria,2G7ZJ@200795|Chloroflexi,3768I@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD1_k127_2198757_3	177439.DP2251	5.329e-56	198.0	COG1720@1|root,COG1720@2|Bacteria,1MUF0@1224|Proteobacteria,42T7R@68525|delta/epsilon subdivisions,2WPDU@28221|Deltaproteobacteria,2MK9K@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_2198757_2	1267535.KB906767_gene2004	2.835e-96	325.0	COG3391@1|root,COG3391@2|Bacteria,3Y4CD@57723|Acidobacteria,2JJ1Y@204432|Acidobacteriia	204432|Acidobacteriia	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2198757_4	189753.AXAS01000002_gene5413	9.659e-39	161.0	COG3391@1|root,COG3391@2|Bacteria,1RFWG@1224|Proteobacteria,2U7T8@28211|Alphaproteobacteria,3K2MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2198757_1	1040989.AWZU01000016_gene2485	1.441e-108	356.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3JSVF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_2214435_3	909663.KI867150_gene1328	1.751e-38	152.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,42R5H@68525|delta/epsilon subdivisions,2WNZS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD1_k127_2214435_6	1379698.RBG1_1C00001G0502	4.114e-17	93.0	COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD1_k127_2214435_4	1125863.JAFN01000001_gene888	5.159e-37	147.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,42TXX@68525|delta/epsilon subdivisions,2WQBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,Peptidase_S15
HKD1_k127_2214435_2	1123376.AUIU01000011_gene937	6.184e-47	184.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD1_k127_2214435_0	861299.J421_3591	1.169e-56	211.0	COG1028@1|root,COG1028@2|Bacteria,1ZTNC@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD1_k127_2214435_5	1337936.IJ00_19120	2.324e-17	93.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,1HKH8@1161|Nostocales	1117|Cyanobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_2214435_1	1123060.JONP01000015_gene4443	5.424e-56	203.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,2JPTF@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_2217854_0	1123073.KB899244_gene352	3.358e-11	73.0	COG4319@1|root,COG4319@2|Bacteria,1QDB7@1224|Proteobacteria,1T990@1236|Gammaproteobacteria,1XBUD@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_2238201_2	1382304.JNIL01000001_gene2934	1.588e-37	149.0	COG0624@1|root,COG0624@2|Bacteria,1TYR6@1239|Firmicutes,4HCVC@91061|Bacilli	91061|Bacilli	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_2238201_1	401526.TcarDRAFT_1876	2.046e-103	351.0	COG3069@1|root,COG3069@2|Bacteria,1TRIV@1239|Firmicutes,4H3U0@909932|Negativicutes	909932|Negativicutes	C	Transporter anaerobic C4-dicarboxylate uptake C	dcuC	-	-	ko:K03326	-	-	-	-	ko00000,ko02000	2.A.61.1	-	-	DcuC
HKD1_k127_2238201_0	671143.DAMO_2544	1.914e-117	387.0	COG0150@1|root,COG0150@2|Bacteria,2NNUJ@2323|unclassified Bacteria	2|Bacteria	F	AIR synthase related protein, N-terminal domain	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1,6.3.4.13	ko:K01933,ko:K11788	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04208	RC00090,RC00166,RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1844,iECSF_1327.ECSF_2340	AIRS,AIRS_C
HKD1_k127_2238201_3	671143.DAMO_1159	1.019e-30	126.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2NNTX@2323|unclassified Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20	ko:K01874,ko:K01890	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD1_k127_2262436_0	909663.KI867149_gene3178	0.0	1363.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MRGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_2262436_1	909663.KI867149_gene3178	0.0	1343.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MRGT@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_2262436_27	1122918.KB907282_gene4956	1.017e-39	154.0	COG3506@1|root,COG3506@2|Bacteria,1V1CZ@1239|Firmicutes,4HVWU@91061|Bacilli,26UNM@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1349)	yjl217W	-	-	ko:K09702	-	-	-	-	ko00000	-	-	-	DUF1349
HKD1_k127_2262436_26	1121087.AUCK01000002_gene2439	3.218e-41	161.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli,1ZBS6@1386|Bacillus	91061|Bacilli	K	transcriptional	yvoA	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD1_k127_2262436_20	696369.KI912183_gene1352	7.853e-63	229.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,263FM@186807|Peptococcaceae	186801|Clostridia	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_2262436_21	370438.PTH_0276	1.26e-60	217.0	COG1878@1|root,COG1878@2|Bacteria,1TSXB@1239|Firmicutes,24B80@186801|Clostridia,2624J@186807|Peptococcaceae	186801|Clostridia	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD1_k127_2262436_22	266117.Rxyl_2988	1.327e-59	223.0	COG1995@1|root,COG1995@2|Bacteria,2GRPG@201174|Actinobacteria	201174|Actinobacteria	H	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_2262436_19	1449126.JQKL01000008_gene233	7.116e-65	237.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,269C3@186813|unclassified Clostridiales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_2262436_32	1265502.KB905929_gene2249	1.278e-20	98.0	COG3090@1|root,COG3090@2|Bacteria,1R3YK@1224|Proteobacteria,2WFEZ@28216|Betaproteobacteria,4AJSE@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_2262436_6	1380394.JADL01000004_gene6127	7.214e-139	459.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQGA@204441|Rhodospirillales	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_2262436_25	429009.Adeg_0287	2.209e-41	163.0	COG1028@1|root,COG1028@2|Bacteria,1TZY6@1239|Firmicutes,248QZ@186801|Clostridia,42EQW@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG5	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_2262436_11	1501230.ET33_05725	4.175e-114	374.0	COG0667@1|root,COG0667@2|Bacteria,1UHXA@1239|Firmicutes,4HDI7@91061|Bacilli,26U1C@186822|Paenibacillaceae	91061|Bacilli	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_2262436_13	1380394.JADL01000007_gene4580	5.524e-106	353.0	COG0715@1|root,COG0715@2|Bacteria,1MWJF@1224|Proteobacteria,2TT19@28211|Alphaproteobacteria	2|Bacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD1_k127_2262436_8	94624.Bpet0412	4.278e-122	397.0	COG1116@1|root,COG1116@2|Bacteria,1MUYG@1224|Proteobacteria,2VHDU@28216|Betaproteobacteria,3T2MF@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_2262436_7	94624.Bpet0411	9.565e-127	411.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2VJ97@28216|Betaproteobacteria,3T3G2@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_2262436_17	1380394.JADL01000010_gene4385	6.303e-85	291.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,2VF56@28211|Alphaproteobacteria,2JWVZ@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2262436_12	1123501.KB902297_gene3603	5.756e-108	359.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TS46@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_2262436_30	252305.OB2597_06030	3.559e-24	109.0	COG3090@1|root,COG3090@2|Bacteria,1RM4J@1224|Proteobacteria,2UKDE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_2262436_5	252305.OB2597_06025	7.233e-151	490.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2PDPV@252301|Oceanicola	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_2262436_29	296591.Bpro_1458	1.541e-32	138.0	COG1082@1|root,COG1082@2|Bacteria,1R963@1224|Proteobacteria,2W0J1@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_2262436_33	933262.AXAM01000059_gene2918	3.453e-08	64.0	COG1555@1|root,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	-	ko:K02237,ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Cu_amine_oxidN1,HHH_3,Lactamase_B,SLBB
HKD1_k127_2262436_23	246197.MXAN_6314	1.645e-48	183.0	COG3394@1|root,COG3394@2|Bacteria,1MX3P@1224|Proteobacteria,42TZT@68525|delta/epsilon subdivisions,2WQ2A@28221|Deltaproteobacteria,2YYV7@29|Myxococcales	28221|Deltaproteobacteria	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HKD1_k127_2262436_2	696369.KI912183_gene1935	1.035e-177	573.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_2262436_4	398767.Glov_2278	2.754e-156	507.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,42MGZ@68525|delta/epsilon subdivisions,2WIY6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Belongs to the DEAD box helicase family	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C,R3H
HKD1_k127_2262436_35	334545.CCMG01000026_gene1530	3.995e-05	50.0	COG0457@1|root,COG0457@2|Bacteria	334545.CCMG01000026_gene1530|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2262436_28	671143.DAMO_1850	5.694e-33	133.0	COG3536@1|root,COG3536@2|Bacteria,2NQ65@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
HKD1_k127_2262436_14	671143.DAMO_1849	1.175e-104	349.0	COG1063@1|root,COG1063@2|Bacteria,2NPFX@2323|unclassified Bacteria	2|Bacteria	E	Glucose dehydrogenase C-terminus	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_2262436_9	671143.DAMO_1848	8.311e-121	407.0	COG1063@1|root,COG1063@2|Bacteria,2NR1V@2323|unclassified Bacteria	2|Bacteria	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_2262436_34	743525.TSC_c12250	1.917e-07	56.0	2DSVR@1|root,33HKS@2|Bacteria,1WKIU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1,RHH_3,RHH_4
HKD1_k127_2262436_31	891968.Anamo_1094	5.18e-22	101.0	COG2402@1|root,COG2402@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07065	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_2262436_16	1038859.AXAU01000002_gene400	5.902e-86	303.0	COG1653@1|root,COG1653@2|Bacteria,1PEBV@1224|Proteobacteria,2V8NU@28211|Alphaproteobacteria,3K0ZY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_2262436_15	1038859.AXAU01000002_gene399	6.68e-90	307.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2U351@28211|Alphaproteobacteria,3JUAH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2262436_18	1038859.AXAU01000002_gene398	9.749e-85	288.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VFFM@28211|Alphaproteobacteria,3JYFJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2262436_3	1121422.AUMW01000006_gene781	2.076e-172	556.0	COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,247ZG@186801|Clostridia,2617N@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the 3-oxoacid CoA-transferase family	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_2262436_24	1499967.BAYZ01000089_gene5042	1.391e-45	169.0	COG2030@1|root,COG2030@2|Bacteria,2NRNG@2323|unclassified Bacteria	2|Bacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_2262436_10	246194.CHY_1350	1.413e-118	392.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,42FF9@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Acyl-CoA dehydrogenase	bcd2	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,ETF_alpha,Rubredoxin
HKD1_k127_2262436_37	1329516.JPST01000003_gene1196	0.0001028	45.0	COG1028@1|root,COG1028@2|Bacteria,1TSCT@1239|Firmicutes,4HD4Z@91061|Bacilli,27CWA@186824|Thermoactinomycetaceae	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2265361_4	1121106.JQKB01000063_gene61	3.194e-53	200.0	COG1653@1|root,COG1653@2|Bacteria,1MXY4@1224|Proteobacteria,2TS7N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_2265361_2	1408254.T458_26080	2.888e-80	282.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,4HB6X@91061|Bacilli,26WJP@186822|Paenibacillaceae	91061|Bacilli	C	Malate/L-lactate dehydrogenase	-	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
HKD1_k127_2265361_3	1157708.KB907454_gene3047	4.346e-72	253.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria	1224|Proteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_2265361_0	1049564.TevJSym_aa02060	5.494e-158	517.0	COG4715@1|root,COG4715@2|Bacteria,1R60K@1224|Proteobacteria,1S0TU@1236|Gammaproteobacteria,1JAXM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	SWIM zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HKD1_k127_2265361_9	671143.DAMO_2932	8.634e-09	58.0	COG5304@1|root,COG5304@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin,CopG_antitoxin
HKD1_k127_2265361_6	163908.KB235896_gene3284	3.684e-28	115.0	COG2442@1|root,COG2442@2|Bacteria,1GACC@1117|Cyanobacteria,1HQ0P@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_2265361_8	667014.Thein_2003	3.517e-12	69.0	2DSNR@1|root,33GUE@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2265361_5	313612.L8106_19071	5.591e-31	123.0	2E46S@1|root,32Z2Q@2|Bacteria,1G7T4@1117|Cyanobacteria,1HCIX@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2265361_7	497965.Cyan7822_4463	5.312e-17	83.0	COG2442@1|root,COG2442@2|Bacteria,1GKGR@1117|Cyanobacteria,3KJ0X@43988|Cyanothece	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_2265361_1	671143.DAMO_1977	1.658e-102	345.0	COG0732@1|root,COG0732@2|Bacteria	2|Bacteria	V	type I restriction modification DNA specificity domain	hsdS	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
HKD1_k127_2272196_0	713586.KB900536_gene2659	1.522e-136	446.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_28,HTH_32,LZ_Tnp_IS481,rve,rve_3
HKD1_k127_2272196_2	455632.SGR_1194	1.289e-12	81.0	COG2267@1|root,COG2267@2|Bacteria,2GNE3@201174|Actinobacteria	201174|Actinobacteria	I	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	3HBOH,Tannase
HKD1_k127_2272196_1	1500894.JQNN01000001_gene2104	9.545e-69	250.0	COG2755@1|root,COG2755@2|Bacteria,1MXBN@1224|Proteobacteria,2VPAT@28216|Betaproteobacteria,472W0@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_2278373_4	452637.Oter_3889	7.291e-17	82.0	COG2025@1|root,COG2025@2|Bacteria	2|Bacteria	C	fatty acid beta-oxidation using acyl-CoA dehydrogenase	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	Acyl-CoA_dh_1,ETF,ETF_alpha
HKD1_k127_2278373_2	452637.Oter_3888	8.15e-129	415.0	COG2086@1|root,COG2086@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_2278373_1	452637.Oter_3887	4.457e-295	919.0	COG0644@1|root,COG1145@1|root,COG0644@2|Bacteria,COG1145@2|Bacteria,46WP0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	oxidoreductase	-	-	1.5.5.1	ko:K00311,ko:K00313	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HKD1_k127_2278373_0	234267.Acid_0094	0.0	1107.0	COG1960@1|root,COG1960@2|Bacteria	2|Bacteria	I	acyl-CoA dehydrogenase activity	fadE23	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_2278373_3	1382304.JNIL01000001_gene1130	2.724e-68	240.0	COG1028@1|root,COG1028@2|Bacteria,1V05R@1239|Firmicutes,4HDCM@91061|Bacilli,279TK@186823|Alicyclobacillaceae	91061|Bacilli	IQ	KR domain	yusR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD1_k127_2306878_7	1469245.JFBG01000068_gene15	3.817e-97	324.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria,1X10G@135613|Chromatiales	135613|Chromatiales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_2306878_2	1207063.P24_14579	2.9e-132	444.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,2JRAR@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_2306878_5	1144319.PMI16_04846	7.895e-107	355.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2VHA0@28216|Betaproteobacteria,477H5@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	ABC-type sugar	-	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HKD1_k127_2306878_4	1123060.JONP01000012_gene2846	1.638e-109	360.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,2JQYY@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2306878_8	644966.Tmar_1677	1.625e-36	144.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_2306878_3	644966.Tmar_1678	1.256e-113	375.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,25B0H@186801|Clostridia	186801|Clostridia	V	SMART ATPase, AAA type, core	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2306878_6	644966.Tmar_1679	1.622e-103	343.0	COG0842@1|root,COG0842@2|Bacteria,1UYEB@1239|Firmicutes,24BUQ@186801|Clostridia,3WDNI@538999|Clostridiales incertae sedis	186801|Clostridia	V	daunorubicin resistance ABC transporter membrane protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_2306878_1	330214.NIDE3529	8.678e-140	466.0	COG0845@1|root,COG0845@2|Bacteria,3J11U@40117|Nitrospirae	40117|Nitrospirae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	-
HKD1_k127_2306878_0	1304885.AUEY01000099_gene2596	0.0	1219.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42NNB@68525|delta/epsilon subdivisions,2WMAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07788	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_2313442_1	1210884.HG799462_gene8316	6.179e-54	199.0	2C32S@1|root,33JPG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2313442_0	485913.Krac_2355	2.611e-120	399.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2G9RC@200795|Chloroflexi	200795|Chloroflexi	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD1_k127_2316578_2	266117.Rxyl_0920	1.22e-124	406.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_2316578_4	266117.Rxyl_0919	1.338e-101	343.0	COG1144@1|root,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K00172,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,Fer4_21,POR
HKD1_k127_2316578_5	880073.Calab_0209	1.725e-99	342.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	-	-	1.17.1.9,1.18.1.2,1.19.1.1,1.5.8.1,1.5.8.2,5.2.1.13	ko:K00123,ko:K00317,ko:K00528,ko:K09835	ko00630,ko00680,ko00906,ko01100,ko01110,ko01120,ko01200,map00630,map00680,map00906,map01100,map01110,map01120,map01200	M00097	R00519,R01588,R02511,R07512,R10159	RC00185,RC00556,RC00557,RC00732,RC01960,RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase,Fer4_20,NAD_binding_8,Oxidored_FMN,Pyr_redox_2
HKD1_k127_2316578_6	671143.DAMO_3057	1.295e-36	149.0	COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD1_k127_2316578_9	1961.JOAK01000043_gene6800	1.21e-18	91.0	COG0745@1|root,COG0745@2|Bacteria,2GMZ7@201174|Actinobacteria	201174|Actinobacteria	T	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2316578_0	880072.Desac_1402	0.0	1362.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_2316578_3	63737.Npun_F1045	6.307e-108	365.0	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria,1HR9W@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_2316578_7	747365.Thena_0983	5.039e-32	133.0	COG0681@1|root,COG0681@2|Bacteria,1V7H9@1239|Firmicutes,24HHW@186801|Clostridia,42G4C@68295|Thermoanaerobacterales	186801|Clostridia	U	PFAM Peptidase S24 S26A S26B, conserved region	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_2316578_1	671143.DAMO_3115	4.808e-148	484.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	degP	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD1_k127_2316578_10	1075090.GOAMR_56_00130	0.0001781	50.0	COG0745@1|root,COG0745@2|Bacteria,2GMG9@201174|Actinobacteria,4GCYH@85026|Gordoniaceae	201174|Actinobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483,ko:K07665	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01504,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2316578_8	1324957.K933_11981	4.503e-19	95.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1P@28890|Euryarchaeota,23TI5@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_2326656_0	113395.AXAI01000002_gene5146	2.946e-139	449.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2U0UX@28211|Alphaproteobacteria,3JWP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2326656_1	1038860.AXAP01000107_gene4557	7.242e-119	391.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TZRR@28211|Alphaproteobacteria,3JTDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2326656_2	1037409.BJ6T_87390	8.963e-119	397.0	COG1653@1|root,COG1653@2|Bacteria,1R5NT@1224|Proteobacteria,2TTRQ@28211|Alphaproteobacteria,3JSBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_2326656_3	1528106.JRJE01000009_gene1666	2.403e-47	173.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,2JPX8@204441|Rhodospirillales	204441|Rhodospirillales	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
HKD1_k127_2327997_0	234267.Acid_6996	0.0	1315.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria	57723|Acidobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_2336661_1	234267.Acid_5646	1.48e-174	550.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HKD1_k127_2336661_0	234267.Acid_5647	8.935e-229	711.0	COG3507@1|root,COG3507@2|Bacteria,3Y89B@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
HKD1_k127_2338339_1	671143.DAMO_3153	1.12e-59	210.0	COG0577@1|root,COG0577@2|Bacteria,2NP20@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	salY	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
HKD1_k127_2338339_3	1380346.JNIH01000052_gene6930	2.574e-28	125.0	COG2120@1|root,COG2120@2|Bacteria,2GIUS@201174|Actinobacteria	201174|Actinobacteria	S	PFAM LmbE family protein	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_2338339_0	1123248.KB893322_gene630	1.468e-69	261.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_2338339_2	1122605.KB893649_gene3709	1.409e-36	159.0	COG0438@1|root,COG0438@2|Bacteria,4NM4T@976|Bacteroidetes,1IW8N@117747|Sphingobacteriia	976|Bacteroidetes	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2338339_4	489825.LYNGBM3L_21130	7.601e-24	102.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_2344845_5	522306.CAP2UW1_2783	2.904e-78	266.0	COG1502@1|root,COG1502@2|Bacteria,1RBXW@1224|Proteobacteria	1224|Proteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD1_k127_2344845_0	522306.CAP2UW1_2784	6.749e-276	861.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2VIAP@28216|Betaproteobacteria,1KPU9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147,ko:K18893	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1,3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_2344845_2	1454004.AW11_02387	7.796e-109	367.0	COG2067@1|root,COG2067@2|Bacteria,1MUU4@1224|Proteobacteria,2VHI3@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Outer membrane protein transport protein, Ompp1 FadL TodX	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD1_k127_2344845_3	1403819.BATR01000118_gene4111	2.642e-106	376.0	COG3264@1|root,COG3264@2|Bacteria,46T7X@74201|Verrucomicrobia,2IWP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_2344845_1	522306.CAP2UW1_1261	7.824e-273	864.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,2VKEC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2344845_4	522306.CAP2UW1_1261	1.426e-92	317.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,2VKEC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2345601_11	632335.Calkr_2138	3.254e-11	69.0	COG1813@1|root,COG1813@2|Bacteria,1VEVE@1239|Firmicutes,25F53@186801|Clostridia	186801|Clostridia	K	PFAM Helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD1_k127_2345601_3	653733.Selin_0517	8.034e-84	283.0	COG1272@1|root,COG1272@2|Bacteria	2|Bacteria	K	protein, Hemolysin III	hly3	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD1_k127_2345601_13	298653.Franean1_2903	3.641e-05	51.0	COG1321@1|root,COG1321@2|Bacteria,2ICG2@201174|Actinobacteria	201174|Actinobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2345601_12	1121918.ARWE01000001_gene3243	2.687e-08	58.0	2DN4U@1|root,32VHV@2|Bacteria,1NDP9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2345601_5	62928.azo2453	5.709e-51	188.0	COG2808@1|root,COG2808@2|Bacteria,1N1B9@1224|Proteobacteria,2VRAJ@28216|Betaproteobacteria,2KWSA@206389|Rhodocyclales	206389|Rhodocyclales	K	Putative FMN-binding domain	-	-	-	ko:K07734	-	-	-	-	ko00000,ko03000	-	-	-	FMN_bind_2
HKD1_k127_2345601_1	1340493.JNIF01000004_gene118	8.283e-112	369.0	COG0412@1|root,COG0412@2|Bacteria,3Y4P0@57723|Acidobacteria	57723|Acidobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD1_k127_2345601_0	1380394.JADL01000001_gene2784	1.807e-129	423.0	COG0500@1|root,COG0500@2|Bacteria,1N3PV@1224|Proteobacteria,2TVNH@28211|Alphaproteobacteria,2JQZB@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_2345601_8	272134.KB731324_gene2628	3.015e-31	136.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	Z012_09115	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_2345601_7	368407.Memar_0519	2.66e-36	154.0	COG0642@1|root,arCOG06192@2157|Archaea,2Y7VU@28890|Euryarchaeota	2157|Archaea	T	ATP-binding region, ATPase domain protein domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_2345601_10	706587.Desti_3480	1.223e-14	76.0	COG3464@1|root,COG3464@2|Bacteria,1QZI9@1224|Proteobacteria,43CJK@68525|delta/epsilon subdivisions	1224|Proteobacteria	L	PFAM Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_2345601_4	1089551.KE386572_gene924	1.085e-68	247.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,2TR3K@28211|Alphaproteobacteria,4BRVC@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Penicillin-insensitive murein endopeptidase	mepA	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
HKD1_k127_2345601_9	883126.HMPREF9710_02354	8.602e-19	93.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,Response_reg
HKD1_k127_2345601_6	215803.DB30_8405	3.184e-45	171.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YTW0@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_2365460_0	338966.Ppro_3267	4.435e-299	944.0	COG3280@1|root,COG3280@2|Bacteria,1QTVK@1224|Proteobacteria,42MEW@68525|delta/epsilon subdivisions,2WJX1@28221|Deltaproteobacteria,43SW5@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Alpha amylase, catalytic domain	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
HKD1_k127_2365460_2	1238182.C882_0986	7.154e-248	781.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,2TVJ1@28211|Alphaproteobacteria,2JQZS@204441|Rhodospirillales	204441|Rhodospirillales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416,hDGE_amylase
HKD1_k127_2365460_1	1128421.JAGA01000004_gene2674	1.661e-277	861.0	COG0366@1|root,COG0366@2|Bacteria,2NQND@2323|unclassified Bacteria	2|Bacteria	G	Maltogenic Amylase, C-terminal domain	treS	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	APH,Alpha-amylase,Malt_amylase_C
HKD1_k127_2365460_3	1128421.JAGA01000003_gene2723	2.148e-145	476.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_2370186_15	936455.KI421499_gene3182	1.9e-38	145.0	COG4134@1|root,COG4134@2|Bacteria,1N6GY@1224|Proteobacteria,2U0KB@28211|Alphaproteobacteria,3K21E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD1_k127_2370186_0	936455.KI421499_gene3181	1.579e-142	462.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQMJ@28211|Alphaproteobacteria,3JRKH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	-	-	-	ko:K02049,ko:K02052	ko02024,map02024	M00188,M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11,3.A.1.16,3.A.1.17	-	-	ABC_tran,TOBE_2
HKD1_k127_2370186_2	936455.KI421499_gene3180	2.54e-126	411.0	COG1176@1|root,COG1176@2|Bacteria,1PE8C@1224|Proteobacteria,2U3DM@28211|Alphaproteobacteria,3K3BG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD1_k127_2370186_3	1037409.BJ6T_56670	8.66e-125	404.0	COG1177@1|root,COG1177@2|Bacteria,1NTF5@1224|Proteobacteria,2U2YS@28211|Alphaproteobacteria,3K2P6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD1_k127_2370186_5	1396418.BATQ01000110_gene4803	1.149e-110	387.0	COG3264@1|root,COG3264@2|Bacteria,46T7X@74201|Verrucomicrobia,2IWP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_2370186_6	445972.ANACOL_03511	2.21e-102	346.0	COG4948@1|root,COG4948@2|Bacteria,1TS0S@1239|Firmicutes,24AE7@186801|Clostridia,3WP52@541000|Ruminococcaceae	186801|Clostridia	M	Mandelate racemase muconate lactonizing enzyme, N-terminal domain	-	-	4.2.1.5,4.2.1.6	ko:K01683,ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_2370186_17	760568.Desku_1542	8.4e-26	114.0	2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes,24SN5@186801|Clostridia,262GJ@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2370186_10	910964.GEAM_2430	1.916e-65	229.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2311,iAPECO1_1312.APECO1_4253,iB21_1397.B21_02196,iBWG_1329.BWG_2085,iE2348C_1286.E2348C_2451,iEC55989_1330.EC55989_2555,iECBD_1354.ECBD_1348,iECB_1328.ECB_02236,iECDH10B_1368.ECDH10B_2473,iECDH1ME8569_1439.ECDH1ME8569_2249,iECD_1391.ECD_02236,iECED1_1282.ECED1_2775,iECH74115_1262.ECH74115_3451,iECIAI39_1322.ECIAI39_2460,iECNA114_1301.ECNA114_2401,iECO103_1326.ECO103_2775,iECOK1_1307.ECOK1_2544,iECP_1309.ECP_2350,iECS88_1305.ECS88_2458,iECSE_1348.ECSE_2620,iECSF_1327.ECSF_2187,iECSP_1301.ECSP_3186,iECs_1301.ECs3195,iETEC_1333.ETEC_2447,iEcDH1_1363.EcDH1_1345,iEcE24377_1341.EcE24377A_2605,iEcHS_1320.EcHS_A2462,iEcSMS35_1347.EcSMS35_2467,iG2583_1286.G2583_2848,iJO1366.b2311,iJR904.b2311,iLF82_1304.LF82_2354,iNRG857_1313.NRG857_11705,iSDY_1059.SDY_2510,iUMN146_1321.UM146_05255,iUMNK88_1353.UMNK88_2862,iUTI89_1310.UTI89_C2595,iY75_1357.Y75_RS12120,iZ_1308.Z3573	Flavoprotein
HKD1_k127_2370186_4	671143.DAMO_1524	3.163e-111	364.0	COG0682@1|root,COG0682@2|Bacteria,2NPK2@2323|unclassified Bacteria	2|Bacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008961,GO:0009058,GO:0009059,GO:0009249,GO:0009898,GO:0009987,GO:0010467,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0036211,GO:0042157,GO:0042158,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051604,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.1.1.199	ko:K03438,ko:K13292	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	LGT
HKD1_k127_2370186_13	552811.Dehly_0347	3.755e-49	188.0	COG0702@1|root,COG0702@2|Bacteria,2G6I7@200795|Chloroflexi,34CR0@301297|Dehalococcoidia	301297|Dehalococcoidia	M	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
HKD1_k127_2370186_20	671143.DAMO_1268	7.085e-17	84.0	COG2331@1|root,COG2331@2|Bacteria	2|Bacteria	P	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_2370186_25	1379281.AVAG01000040_gene797	0.0002575	49.0	2ECCP@1|root,33IDE@2|Bacteria,1NQFP@1224|Proteobacteria,42XDI@68525|delta/epsilon subdivisions,2WTE0@28221|Deltaproteobacteria,2MH80@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2370186_22	1278073.MYSTI_07655	2.601e-10	70.0	2EIZM@1|root,33CQT@2|Bacteria,1P1YR@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2370186_23	555779.Dthio_PD0961	1.507e-09	63.0	2CKUB@1|root,34BQT@2|Bacteria,1P2NW@1224|Proteobacteria,431FP@68525|delta/epsilon subdivisions,2WW8P@28221|Deltaproteobacteria,2MFE3@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2370186_1	1449126.JQKL01000002_gene1600	2.231e-126	417.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,268RD@186813|unclassified Clostridiales	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_2370186_19	1499967.BAYZ01000177_gene5753	2.09e-23	106.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_2370186_11	1449126.JQKL01000008_gene233	2.008e-61	226.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,269C3@186813|unclassified Clostridiales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_2370186_16	671143.DAMO_0756	3.313e-36	152.0	COG0477@1|root,COG2814@2|Bacteria,2NRCB@2323|unclassified Bacteria	2|Bacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_2370186_12	1408164.MOLA814_00278	8.204e-53	199.0	COG2084@1|root,COG2084@2|Bacteria,1MV48@1224|Proteobacteria,2VKTQ@28216|Betaproteobacteria	28216|Betaproteobacteria	I	6-phosphogluconate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_2370186_14	1227739.Hsw_2696	2.608e-45	174.0	COG2227@1|root,COG2227@2|Bacteria,4PKW0@976|Bacteroidetes,47PVE@768503|Cytophagia	976|Bacteroidetes	H	Methyltransferase domain	cypM_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD1_k127_2370186_9	266117.Rxyl_3010	2.515e-72	256.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4CSY8@84995|Rubrobacteria	84995|Rubrobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_2370186_21	1382356.JQMP01000003_gene2446	9.349e-12	72.0	COG3191@1|root,COG3191@2|Bacteria,2G83F@200795|Chloroflexi,27YT6@189775|Thermomicrobia	189775|Thermomicrobia	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD1_k127_2370186_8	671143.DAMO_1169	4.728e-80	274.0	2C8XG@1|root,2Z7PK@2|Bacteria,2NR2W@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF4197)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4197
HKD1_k127_2370186_18	640081.Dsui_3156	1.879e-24	113.0	COG0730@1|root,COG0730@2|Bacteria,1RKNK@1224|Proteobacteria,2VY8V@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_2370186_7	365044.Pnap_3244	3.469e-101	346.0	COG0265@1|root,COG0265@2|Bacteria,1QWA4@1224|Proteobacteria,2VK6X@28216|Betaproteobacteria,4A9X2@80864|Comamonadaceae	28216|Betaproteobacteria	O	peptidase S1 and S6, chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_2384524_3	1128421.JAGA01000001_gene2382	8.82e-91	304.0	COG4992@1|root,COG4992@2|Bacteria,2NP0N@2323|unclassified Bacteria	2|Bacteria	E	acetylornithine and succinylornithine aminotransferase	lysJ	-	2.6.1.11,2.6.1.17	ko:K00821,ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00031,M00763,M00845	R02283,R04475,R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,Peptidase_M20
HKD1_k127_2384524_2	926554.KI912628_gene2723	1.406e-99	334.0	COG0548@1|root,COG0548@2|Bacteria,1WIHT@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Belongs to the acetylglutamate kinase family. LysZ subfamily	lysZ	GO:0003674,GO:0003824,GO:0003991,GO:0005488,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016597,GO:0016740,GO:0016772,GO:0016774,GO:0019752,GO:0031406,GO:0034618,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_2384524_0	1191523.MROS_0164	2.653e-138	455.0	COG0002@1|root,COG0002@2|Bacteria	2|Bacteria	E	N-acetyl-gamma-glutamyl-phosphate reductase activity	argC	-	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_2384524_1	324602.Caur_0334	2.141e-132	428.0	COG0189@1|root,COG0189@2|Bacteria,2G5RN@200795|Chloroflexi,374VK@32061|Chloroflexia	32061|Chloroflexia	HJ	PFAM ATP-dependent carboxylate-amine ligase domain protein, ATP-grasp	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
HKD1_k127_2384524_5	926550.CLDAP_04840	2.253e-14	74.0	2DRHT@1|root,33BTG@2|Bacteria,2G7I1@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM lysine biosynthesis protein LysW	-	-	-	ko:K05826	-	M00031,M00763	-	-	ko00000,ko00001,ko00002	-	-	-	-
HKD1_k127_2384524_4	351160.RCIX924	2.226e-36	148.0	COG1011@1|root,arCOG02291@2157|Archaea	2157|Archaea	S	hydrolase (HAD superfamily)	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD1_k127_23883_0	85643.Tmz1t_1479	1.229e-231	723.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,2VY2Q@28216|Betaproteobacteria,2KXWX@206389|Rhodocyclales	206389|Rhodocyclales	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
HKD1_k127_23883_1	1174528.JH992892_gene6417	2.083e-54	192.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_2411517_0	765911.Thivi_2047	1.711e-92	319.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WWWX@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_2416037_1	211165.AJLN01000066_gene4498	8.929e-92	305.0	COG1600@1|root,COG3255@1|root,COG1600@2|Bacteria,COG3255@2|Bacteria,1G07Y@1117|Cyanobacteria	1117|Cyanobacteria	CI	PFAM 4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Dehalogenase,Fer4,Fer4_7,SCP2
HKD1_k127_2416037_2	1341151.ASZU01000016_gene774	2.204e-82	298.0	COG0654@1|root,COG0654@2|Bacteria,1TXG1@1239|Firmicutes,4IJW6@91061|Bacilli,27D42@186824|Thermoactinomycetaceae	91061|Bacilli	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD1_k127_2416037_4	404589.Anae109_3659	0.000958	45.0	COG2220@1|root,COG2220@2|Bacteria,1PZVZ@1224|Proteobacteria,4398Q@68525|delta/epsilon subdivisions,2X4FZ@28221|Deltaproteobacteria,2Z1VW@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_2416037_3	324602.Caur_3333	5.019e-06	51.0	2A4K7@1|root,30T6V@2|Bacteria,2GB43@200795|Chloroflexi,377VP@32061|Chloroflexia	32061|Chloroflexia	S	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.	-	-	-	-	-	-	-	-	-	-	-	-	Frankia_peptide
HKD1_k127_2416037_0	204669.Acid345_1618	5.631e-110	361.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2419783_0	748280.NH8B_3131	6.236e-121	428.0	COG1361@1|root,COG1361@2|Bacteria,1MUQC@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Peptidase M11 gametolysin	-	-	-	-	-	-	-	-	-	-	-	-	NPCBM_assoc,Peptidase_M11,Reprolysin_5,RicinB_lectin_2
HKD1_k127_2429666_4	696747.NIES39_J05350	2.622e-08	60.0	COG0436@1|root,COG0436@2|Bacteria,1G2TF@1117|Cyanobacteria,1H73T@1150|Oscillatoriales	1117|Cyanobacteria	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_2429666_5	456442.Mboo_2096	2.409e-05	48.0	COG0436@1|root,arCOG01133@2157|Archaea,2XU6A@28890|Euryarchaeota,2N9FK@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_2429666_2	304371.MCP_2158	1.902e-28	120.0	COG3603@1|root,arCOG05233@2157|Archaea,2Y1ZW@28890|Euryarchaeota,2NB8G@224756|Methanomicrobia	224756|Methanomicrobia	S	ACT domain	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
HKD1_k127_2429666_1	1499967.BAYZ01000088_gene5057	9.852e-92	311.0	COG2006@1|root,COG2006@2|Bacteria,2NPBD@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_2429666_0	1499967.BAYZ01000088_gene5058	1.762e-159	519.0	COG0348@1|root,COG1143@1|root,COG1148@1|root,COG0348@2|Bacteria,COG1143@2|Bacteria,COG1148@2|Bacteria,2NP1X@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	napF	-	-	ko:K02572	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_5,Fer4_6,Fer4_7
HKD1_k127_2429666_3	1168289.AJKI01000011_gene482	1.619e-22	104.0	COG1453@1|root,COG1453@2|Bacteria,4NJU2@976|Bacteroidetes,2G2UD@200643|Bacteroidia	976|Bacteroidetes	S	Aldo/keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD1_k127_2433873_16	880072.Desac_1360	4.227e-20	97.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,42NF0@68525|delta/epsilon subdivisions,2WIJK@28221|Deltaproteobacteria,2MQFN@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD1_k127_2433873_0	671143.DAMO_1565	2.065e-317	979.0	COG0465@1|root,COG0465@2|Bacteria,2NNQ5@2323|unclassified Bacteria	2|Bacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	GO:0000166,GO:0003674,GO:0003824,GO:0004175,GO:0004176,GO:0004222,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009056,GO:0009057,GO:0010468,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019222,GO:0019538,GO:0030145,GO:0030163,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043273,GO:0044238,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0098796,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_2433873_6	671143.DAMO_1563	8.595e-89	302.0	COG1624@1|root,COG1624@2|Bacteria,2NPQS@2323|unclassified Bacteria	2|Bacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
HKD1_k127_2433873_10	671143.DAMO_1561	3.366e-47	177.0	COG4856@1|root,COG4856@2|Bacteria,2NQ44@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	dacA	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD1_k127_2433873_1	671143.DAMO_1560	1.483e-197	625.0	COG1109@1|root,COG1109@2|Bacteria,2NNWU@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	GO:0003674,GO:0003824,GO:0004614,GO:0004615,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006047,GO:0006048,GO:0006139,GO:0006464,GO:0006468,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008966,GO:0009058,GO:0009225,GO:0009226,GO:0009987,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0018130,GO:0019438,GO:0019538,GO:0034641,GO:0034654,GO:0036211,GO:0040007,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046483,GO:0046777,GO:0055086,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901576	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1886,iSBO_1134.SBO_3206	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_2433873_9	338963.Pcar_1002	4.098e-54	198.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,42NZY@68525|delta/epsilon subdivisions,2WJDY@28221|Deltaproteobacteria,43UAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1885	PdxJ
HKD1_k127_2433873_14	671143.DAMO_1557	1.117e-26	116.0	COG0736@1|root,COG0736@2|Bacteria,2NPTD@2323|unclassified Bacteria	2|Bacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008897,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016772,GO:0016780,GO:0018070,GO:0018193,GO:0018209,GO:0018215,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901564,GO:1901576	2.7.8.7,3.2.1.52	ko:K00997,ko:K01207	ko00520,ko00531,ko00770,ko01100,ko01501,map00520,map00531,map00770,map01100,map01501	M00628	R00022,R01625,R05963,R07809,R07810,R10831	RC00002,RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	ACPS
HKD1_k127_2433873_3	671143.DAMO_1556	3e-166	539.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,2NNR2@2323|unclassified Bacteria	2|Bacteria	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	GO:0003674,GO:0003824,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0052855,GO:0052856,GO:0052857	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD1_k127_2433873_2	243231.GSU2308	1.508e-166	536.0	COG0281@1|root,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,42MDI@68525|delta/epsilon subdivisions,2WIVY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	malic protein domain protein	-	-	1.1.1.38,1.1.1.40	ko:K00027,ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,ko02020,map00620,map00710,map01100,map01120,map01200,map02020	M00169,M00172	R00214,R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,malic
HKD1_k127_2433873_15	378806.STAUR_4729	1.582e-25	115.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,42VU4@68525|delta/epsilon subdivisions,2WQBA@28221|Deltaproteobacteria,2YW3H@29|Myxococcales	28221|Deltaproteobacteria	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	yjeE	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD1_k127_2433873_13	404380.Gbem_2312	4.151e-32	142.0	COG1102@1|root,COG2823@1|root,COG1102@2|Bacteria,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,42TW4@68525|delta/epsilon subdivisions,2WQ5J@28221|Deltaproteobacteria,43SXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
HKD1_k127_2433873_11	1123256.KB907936_gene2558	6.701e-47	184.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1X5ZT@135614|Xanthomonadales	135614|Xanthomonadales	EGP	Nucleoside H+ symporter	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
HKD1_k127_2433873_5	443144.GM21_2012	2.703e-111	388.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,43CB2@68525|delta/epsilon subdivisions,2X7MH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2433873_8	555088.DealDRAFT_2928	3.145e-63	234.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	MA20_23315	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_2433873_7	671143.DAMO_1553	9.865e-75	271.0	COG1214@1|root,COG1214@2|Bacteria,2NPK8@2323|unclassified Bacteria	2|Bacteria	O	Glycoprotease family	yeaZ	GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K14742	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_2433873_12	671143.DAMO_1552	2.862e-38	152.0	COG0454@1|root,COG0456@2|Bacteria,2NPTV@2323|unclassified Bacteria	2|Bacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_2433873_17	671143.DAMO_1551	6.561e-18	85.0	COG2835@1|root,COG2835@2|Bacteria,2NQ60@2323|unclassified Bacteria	2|Bacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD1_k127_2433873_4	880073.Calab_0536	2.303e-121	396.0	COG1209@1|root,COG1209@2|Bacteria,2NNTJ@2323|unclassified Bacteria	2|Bacteria	M	Nucleotidyl transferase	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD1_k127_2436829_7	335543.Sfum_2574	2.056e-97	334.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,42NCJ@68525|delta/epsilon subdivisions,2WM7Z@28221|Deltaproteobacteria,2MQJH@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
HKD1_k127_2436829_3	1293054.HSACCH_00207	1.441e-157	506.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD1_k127_2436829_10	429009.Adeg_0470	4.314e-73	265.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,42ET8@68295|Thermoanaerobacterales	186801|Clostridia	G	Transketolase, central region	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_2436829_11	316067.Geob_1367	3.363e-70	248.0	COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,42P7U@68525|delta/epsilon subdivisions,2WKZQ@28221|Deltaproteobacteria,43RXC@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	PFAM Transketolase domain protein	tklA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_2436829_13	1293054.HSACCH_01642	9.267e-58	216.0	COG1082@1|root,COG1082@2|Bacteria,1UITG@1239|Firmicutes,25FCS@186801|Clostridia	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_2436829_15	526227.Mesil_3299	2.644e-47	182.0	COG1028@1|root,COG1028@2|Bacteria,1WM8P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2436829_6	1205680.CAKO01000038_gene1586	1.452e-113	390.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JRXA@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_2436829_1	706587.Desti_3265	2.881e-167	548.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_2436829_19	78245.Xaut_1331	2.474e-08	62.0	2D22U@1|root,3160H@2|Bacteria,1RGW1@1224|Proteobacteria,2U97W@28211|Alphaproteobacteria,3EZRA@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_2436829_8	671143.DAMO_0872	3.978e-91	307.0	COG2267@1|root,COG2267@2|Bacteria,2NRR1@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_2436829_16	1128421.JAGA01000001_gene2006	6.161e-43	160.0	COG2363@1|root,COG2363@2|Bacteria,2NRMS@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF423)	ywdK	-	-	-	-	-	-	-	-	-	-	-	DUF423
HKD1_k127_2436829_18	1121468.AUBR01000007_gene266	1.773e-13	74.0	COG5304@1|root,COG5304@2|Bacteria,1VK0G@1239|Firmicutes,251YC@186801|Clostridia	186801|Clostridia	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
HKD1_k127_2436829_17	477974.Daud_1518	1.522e-14	76.0	COG2929@1|root,COG2929@2|Bacteria,1VBN0@1239|Firmicutes,24N5K@186801|Clostridia,265V0@186807|Peptococcaceae	186801|Clostridia	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD1_k127_2436829_2	1232410.KI421421_gene3821	1.199e-164	524.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,42MK7@68525|delta/epsilon subdivisions,2WJCJ@28221|Deltaproteobacteria,43T63@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Fructose-bisphosphate aldolase class-II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_2436829_5	563192.HMPREF0179_03307	2.112e-125	416.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,42NVM@68525|delta/epsilon subdivisions,2WJHT@28221|Deltaproteobacteria,2MFBY@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_3
HKD1_k127_2436829_14	706587.Desti_2100	4.48e-50	194.0	COG0407@1|root,COG0407@2|Bacteria,1P737@1224|Proteobacteria,4328N@68525|delta/epsilon subdivisions,2WYF5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2436829_12	697281.Mahau_1084	6.337e-70	243.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
HKD1_k127_2436829_9	880073.Calab_2491	5.433e-81	282.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_2436829_4	196490.AUEZ01000007_gene5132	1.649e-145	473.0	COG3069@1|root,COG3069@2|Bacteria	2|Bacteria	C	C4-dicarboxylate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2436829_0	196490.AUEZ01000007_gene5131	5.183e-261	822.0	COG0145@1|root,COG0145@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,3JSA9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EQ	Hydantoinase/oxoprolinase	-	-	-	-	-	-	-	-	-	-	-	-	Hydant_A_N,Hydantoinase_A
HKD1_k127_2457394_2	671143.DAMO_1259	9.066e-53	194.0	COG1309@1|root,COG1309@2|Bacteria,2NQ8G@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	MA20_16815	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_2457394_1	1121396.KB893112_gene1975	4.938e-137	449.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2MHST@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD1_k127_2457394_0	909663.KI867150_gene1589	0.0	1189.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_2471395_0	682795.AciX8_2828	9.352e-136	440.0	COG0028@1|root,COG0028@2|Bacteria,3Y3GJ@57723|Acidobacteria,2JI90@204432|Acidobacteriia	204432|Acidobacteriia	EH	Acetolactate synthase, large subunit	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_2471395_1	1217720.ALOX01000087_gene3048	6.925e-34	134.0	COG1028@1|root,COG1028@2|Bacteria,1MXVZ@1224|Proteobacteria,2TSQ4@28211|Alphaproteobacteria,2JWJB@204441|Rhodospirillales	204441|Rhodospirillales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2474229_0	1267535.KB906767_gene870	1.496e-24	118.0	COG3209@1|root,COG3209@2|Bacteria,3Y7FC@57723|Acidobacteria,2JKK9@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_2474229_1	344747.PM8797T_15481	1.555e-07	59.0	COG2204@1|root,COG2204@2|Bacteria,2IYTN@203682|Planctomycetes	203682|Planctomycetes	T	response regulator	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_2494235_0	886293.Sinac_6049	1.807e-110	360.0	COG2801@1|root,COG2801@2|Bacteria,2IZIZ@203682|Planctomycetes	203682|Planctomycetes	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
HKD1_k127_2494235_2	886293.Sinac_6028	2.576e-36	140.0	COG2963@1|root,COG2963@2|Bacteria,2J14P@203682|Planctomycetes	203682|Planctomycetes	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD1_k127_2494235_1	886293.Sinac_2736	2.233e-102	339.0	COG5433@1|root,COG5433@2|Bacteria,2J2DN@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_2495449_15	909663.KI867150_gene367	2.021e-82	284.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,42U7P@68525|delta/epsilon subdivisions,2WQKY@28221|Deltaproteobacteria,2MQSP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2495449_23	909663.KI867150_gene368	1.532e-54	199.0	COG3784@1|root,COG3784@2|Bacteria,1MYIH@1224|Proteobacteria,42TUM@68525|delta/epsilon subdivisions,2WQJJ@28221|Deltaproteobacteria,2MRRR@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1318
HKD1_k127_2495449_1	1304865.JAGF01000001_gene1608	2.585e-232	734.0	COG1263@1|root,COG1264@1|root,COG1263@2|Bacteria,COG1264@2|Bacteria,2GKPM@201174|Actinobacteria	201174|Actinobacteria	G	Phosphotransferase System	-	-	2.7.1.193,2.7.1.199,2.7.1.208	ko:K02749,ko:K02750,ko:K02778,ko:K02779,ko:K02790,ko:K02791,ko:K02803,ko:K02804	ko00010,ko00500,ko00520,ko02060,ko05111,map00010,map00500,map00520,map02060,map05111	M00265,M00266,M00267,M00268	R02738,R04111,R05199	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.1.1.1,4.A.1.1.10,4.A.1.1.15,4.A.1.1.16,4.A.1.1.2,4.A.1.1.3,4.A.1.1.4,4.A.1.1.5,4.A.1.1.7,4.A.1.1.8	-	-	PTS_EIIB,PTS_EIIC
HKD1_k127_2495449_0	1487953.JMKF01000019_gene2285	0.0	1024.0	COG1080@1|root,COG1080@2|Bacteria,1G0VI@1117|Cyanobacteria,1H86E@1150|Oscillatoriales	1117|Cyanobacteria	G	Phosphotransferase system HPr (HPr) family protein	-	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr,PTS_EIIA_1,PTS_EIIA_2
HKD1_k127_2495449_22	1499967.BAYZ01000095_gene4292	6.291e-55	204.0	COG0524@1|root,COG0524@2|Bacteria	2|Bacteria	G	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	-	-	2.7.1.15,2.7.1.20,2.7.1.213,2.7.1.218,2.7.1.73	ko:K00852,ko:K00856,ko:K10710,ko:K22026	ko00030,ko00230,ko00240,ko01100,map00030,map00230,map00240,map01100	-	R00185,R00513,R01051,R01131,R01228,R02750,R08124	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_2495449_12	96561.Dole_0793	4.164e-121	397.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_2495449_3	1118054.CAGW01000056_gene2118	7.292e-217	698.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,26QTI@186822|Paenibacillaceae	91061|Bacilli	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_2495449_28	671143.DAMO_0811	4.056e-33	131.0	COG0721@1|root,COG0721@2|Bacteria,2NPXC@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD1_k127_2495449_2	671143.DAMO_0810	3.416e-222	701.0	COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_2495449_6	671143.DAMO_0807	1.12e-202	640.0	COG0064@1|root,COG0064@2|Bacteria,2NNPK@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.12,6.3.5.6,6.3.5.7	ko:K01876,ko:K02434	ko00970,ko01100,map00970,map01100	M00359,M00360	R03905,R04212,R05577	RC00010,RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_2495449_24	945713.IALB_0020	1.16e-44	169.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00025,M00570	R00220,R00996,R01513,R01728,R01773,R01775	RC00031,RC00087,RC00125,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
HKD1_k127_2495449_21	1298867.AUES01000006_gene427	2.481e-57	221.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2495449_20	1380355.JNIJ01000004_gene2961	3.298e-59	222.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2495449_19	1121405.dsmv_2310	5.634e-60	226.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42U0W@68525|delta/epsilon subdivisions,2WQRX@28221|Deltaproteobacteria,2MPQV@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2495449_31	1255043.TVNIR_3591	1.051e-25	124.0	COG2982@1|root,COG2982@2|Bacteria,1NVUY@1224|Proteobacteria,1RPFM@1236|Gammaproteobacteria,1WXRZ@135613|Chromatiales	135613|Chromatiales	M	PFAM AsmA family protein	-	-	-	ko:K07289	-	-	-	-	ko00000	-	-	-	AsmA
HKD1_k127_2495449_14	671143.DAMO_0804	2.794e-99	334.0	COG0583@1|root,COG0583@2|Bacteria,2NPS6@2323|unclassified Bacteria	2|Bacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_2495449_37	1120971.AUCA01000001_gene1657	1.158e-09	67.0	COG1280@1|root,COG1280@2|Bacteria	2|Bacteria	E	homoserine transmembrane transporter activity	chpE	-	-	ko:K06600,ko:K06895	-	-	-	-	ko00000,ko02000,ko02035	2.A.75.1,2.A.76	-	-	LysE
HKD1_k127_2495449_5	339671.Asuc_1294	9.841e-212	676.0	COG0017@1|root,COG0017@2|Bacteria,1MWFV@1224|Proteobacteria,1RMU4@1236|Gammaproteobacteria,1Y78Z@135625|Pasteurellales	135625|Pasteurellales	J	asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_2495449_10	497964.CfE428DRAFT_4290	1.206e-165	535.0	COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_2495449_8	234267.Acid_2234	3.224e-185	588.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	aspB1	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_2495449_4	401526.TcarDRAFT_0155	1.073e-216	692.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,4H27R@909932|Negativicutes	909932|Negativicutes	P	cadmium-exporting ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_2495449_30	926550.CLDAP_21180	3.724e-26	111.0	COG0640@1|root,COG0640@2|Bacteria,2G6YR@200795|Chloroflexi	200795|Chloroflexi	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD1_k127_2495449_33	323259.Mhun_2016	1.169e-20	102.0	arCOG01632@1|root,arCOG01632@2157|Archaea,2XWWZ@28890|Euryarchaeota,2NAN2@224756|Methanomicrobia	224756|Methanomicrobia	Q	PFAM Methyltransferase type	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25
HKD1_k127_2495449_35	1089552.KI911559_gene1816	1.322e-14	82.0	COG2230@1|root,COG2230@2|Bacteria,1QXKQ@1224|Proteobacteria,2TXBW@28211|Alphaproteobacteria,2JYX5@204441|Rhodospirillales	204441|Rhodospirillales	M	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_2495449_25	552811.Dehly_0860	1.861e-44	169.0	COG1611@1|root,COG1611@2|Bacteria,2G6YH@200795|Chloroflexi,34CSH@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	DNA_processg_A
HKD1_k127_2495449_17	671143.DAMO_3041	5.748e-71	244.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	JAB,Prok-JAB
HKD1_k127_2495449_16	671143.DAMO_2646	3.867e-77	264.0	COG0461@1|root,COG0461@2|Bacteria,2NPFJ@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_2495449_11	767817.Desgi_3802	7.489e-127	426.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,260J2@186807|Peptococcaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	-	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HKD1_k127_2495449_18	671143.DAMO_1472	6.321e-63	227.0	COG2003@1|root,COG2003@2|Bacteria,2NPI9@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	HHH,RadC
HKD1_k127_2495449_13	891968.Anamo_1376	1.25e-107	358.0	COG3181@1|root,COG3181@2|Bacteria,3TB6N@508458|Synergistetes	508458|Synergistetes	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_2495449_9	696281.Desru_1697	1.602e-181	580.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,247UH@186801|Clostridia,263JV@186807|Peptococcaceae	186801|Clostridia	S	PFAM Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_2495449_36	1179773.BN6_43250	3.129e-10	67.0	293R6@1|root,2ZR6U@2|Bacteria,2HRYX@201174|Actinobacteria,4E40R@85010|Pseudonocardiales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_2495449_29	1121406.JAEX01000014_gene2321	4.195e-32	129.0	COG0662@1|root,COG0662@2|Bacteria,1N1XN@1224|Proteobacteria,42TS2@68525|delta/epsilon subdivisions,2WPZ5@28221|Deltaproteobacteria,2MCQX@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2495449_26	469381.Dpep_1065	5.795e-41	155.0	COG0647@1|root,COG0647@2|Bacteria,3TC1F@508458|Synergistetes	508458|Synergistetes	G	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like,NUDIX
HKD1_k127_2495449_7	1105031.HMPREF1141_1839	1.021e-192	617.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_2495449_27	986075.CathTA2_0528	1.692e-33	138.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli	91061|Bacilli	K	transcriptional	yvoA	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD1_k127_249985_4	671143.DAMO_2057	8.735e-109	367.0	COG0820@1|root,COG0820@2|Bacteria,2NP4V@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	GO:0000049,GO:0000154,GO:0001510,GO:0002935,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008175,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016426,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0030488,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0070040,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:0140102,GO:1901360,GO:1901363	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_249985_15	926569.ANT_25310	6.257e-22	108.0	COG1996@1|root,COG1996@2|Bacteria	2|Bacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF4379
HKD1_k127_249985_17	926569.ANT_25300	3.341e-08	65.0	COG2888@1|root,COG2888@2|Bacteria	2|Bacteria	J	peptidyl-tyrosine sulfation	ybeL	-	1.17.4.1,4.6.1.1	ko:K00525,ko:K01768	ko00230,ko00240,ko01100,ko02025,ko04113,ko04213,map00230,map00240,map01100,map02025,map04113,map04213	M00053,M00695	R00089,R00434,R02017,R02018,R02019,R02024	RC00295,RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	DUF1451
HKD1_k127_249985_2	1121396.KB893129_gene32	7.71e-126	413.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,42P7D@68525|delta/epsilon subdivisions,2WJ6S@28221|Deltaproteobacteria,2MIXK@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DZR,SHOCT,zinc_ribbon_2
HKD1_k127_249985_13	671143.DAMO_2058	6.655e-49	186.0	COG0457@1|root,COG0457@2|Bacteria,2NQ11@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
HKD1_k127_249985_6	671143.DAMO_2059	2.967e-94	321.0	COG1559@1|root,COG1559@2|Bacteria,2NP75@2323|unclassified Bacteria	2|Bacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD1_k127_249985_14	1120973.AQXL01000135_gene1406	9.888e-36	142.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,278JB@186823|Alicyclobacillaceae	91061|Bacilli	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD1_k127_249985_10	671143.DAMO_2061	1.98e-70	250.0	COG2231@1|root,COG2231@2|Bacteria,2NR9H@2323|unclassified Bacteria	2|Bacteria	L	endonuclease III	magIII	-	-	ko:K07457	-	-	-	-	ko00000	-	-	-	HhH-GPD
HKD1_k127_249985_0	671143.DAMO_2062	6.039e-292	906.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	LeuA_dimer,PALP
HKD1_k127_249985_12	671143.DAMO_2064	4.722e-64	241.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_249985_7	1267535.KB906767_gene1574	9.1e-81	282.0	COG3481@1|root,COG3481@2|Bacteria,3Y38F@57723|Acidobacteria,2JITD@204432|Acidobacteriia	204432|Acidobacteriia	S	Nucleic acid binding	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HKD1_k127_249985_11	313596.RB2501_14834	2.544e-68	240.0	COG2518@1|root,COG2518@2|Bacteria,4NMTP@976|Bacteroidetes,1I1EU@117743|Flavobacteriia	976|Bacteroidetes	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_249985_1	1303518.CCALI_01952	4.78e-132	439.0	COG0318@1|root,COG0318@2|Bacteria	2|Bacteria	IQ	PFAM AMP-dependent synthetase and ligase	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD1_k127_249985_8	880073.Calab_1753	1.204e-77	274.0	COG3437@1|root,COG3437@2|Bacteria,2NP8B@2323|unclassified Bacteria	2|Bacteria	T	metal-dependent phosphohydrolase HD region	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,Response_reg
HKD1_k127_249985_5	671143.DAMO_2066	1.875e-100	335.0	COG0568@1|root,COG0568@2|Bacteria,2NQT5@2323|unclassified Bacteria	2|Bacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoS	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_249985_3	1125863.JAFN01000001_gene865	7.736e-123	409.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the peptidase S1C family	degP-2	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_249985_16	485915.Dret_2406	7.272e-18	87.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MCVH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
HKD1_k127_249985_9	671143.DAMO_2067	2.507e-72	254.0	COG1912@1|root,COG1912@2|Bacteria,2NPI0@2323|unclassified Bacteria	2|Bacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD1_k127_2506219_27	323261.Noc_1246	5.571e-16	81.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1X2EW@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_2506219_3	1123242.JH636434_gene3641	7.771e-269	845.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_2506219_8	234267.Acid_0497	2.797e-115	381.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HKD1_k127_2506219_17	886293.Sinac_3660	1.984e-81	282.0	COG1999@1|root,COG1999@2|Bacteria,2IYYD@203682|Planctomycetes	203682|Planctomycetes	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_2506219_28	1296990.H845_1002	8.506e-14	77.0	2EJZ3@1|root,33DPP@2|Bacteria,1NKIC@1224|Proteobacteria,2UJFD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2506219_7	1128421.JAGA01000003_gene2874	1.194e-120	408.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2506219_21	204669.Acid345_3000	9.072e-63	224.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_2506219_18	1128421.JAGA01000003_gene2872	6.222e-69	237.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD1_k127_2506219_5	1128421.JAGA01000003_gene2871	6.686e-218	685.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HKD1_k127_2506219_0	472759.Nhal_2603	0.0	1179.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1WWTE@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S	-	-	-	ko:K00184,ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	5.A.3	-	-	Fer4_11,Fer4_4,Fer4_7
HKD1_k127_2506219_15	525904.Tter_1596	1.263e-90	303.0	COG3880@1|root,COG3880@2|Bacteria,2NPCX@2323|unclassified Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	mcsA	GO:0003674,GO:0005488,GO:0005507,GO:0006950,GO:0008150,GO:0008270,GO:0010035,GO:0010038,GO:0042221,GO:0043167,GO:0043169,GO:0046686,GO:0046688,GO:0046870,GO:0046872,GO:0046914,GO:0050896,GO:0050897,GO:0097501,GO:1990169,GO:1990170	2.7.14.1	ko:K19405,ko:K19411	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	Cytochrom_CIII,Cytochrome_C7,GSu_C4xC__C2xCH,UVR
HKD1_k127_2506219_9	204669.Acid345_2220	3.059e-110	366.0	COG1131@1|root,COG1131@2|Bacteria,3Y3I9@57723|Acidobacteria,2JIPJ@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2506219_19	344747.PM8797T_04795	2.898e-67	246.0	COG0842@1|root,COG0842@2|Bacteria,2IZDF@203682|Planctomycetes	203682|Planctomycetes	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_2506219_2	671143.DAMO_1179	5.941e-295	925.0	COG0209@1|root,COG0209@2|Bacteria,2NNVF@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdZ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
HKD1_k127_2506219_12	671143.DAMO_1182	2.612e-101	332.0	COG0717@1|root,COG0717@2|Bacteria,2NQ5G@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HKD1_k127_2506219_25	1121920.AUAU01000017_gene1225	2.798e-18	91.0	COG0748@1|root,COG0748@2|Bacteria,3Y2Q3@57723|Acidobacteria	57723|Acidobacteria	P	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07226	-	-	-	-	ko00000	-	-	-	DUF2470,Pyrid_oxidase_2
HKD1_k127_2506219_4	1121920.AUAU01000004_gene735	3.106e-250	790.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM glutamate formiminotransferase	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
HKD1_k127_2506219_22	926569.ANT_10750	1.258e-60	220.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	yigM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_2506219_1	1499967.BAYZ01000179_gene4626	3.523e-318	987.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5,1.2.7.6	ko:K03738,ko:K11389	ko00010,ko00030,ko01100,ko01120,ko01200,ko01230,map00010,map00030,map01100,map01120,map01200,map01230	M00001,M00002,M00309	R07159,R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_2506219_11	1009370.ALO_08300	3.792e-104	346.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,4H2GI@909932|Negativicutes	909932|Negativicutes	P	ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_2506219_13	401526.TcarDRAFT_0524	9.507e-96	322.0	COG0600@1|root,COG0600@2|Bacteria,1UYCY@1239|Firmicutes,4H2M9@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_2506219_10	1444306.JFZC01000041_gene71	2.919e-106	355.0	COG0715@1|root,COG0715@2|Bacteria,1UYBA@1239|Firmicutes,4HHFE@91061|Bacilli,26Q81@186821|Sporolactobacillaceae	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_2506219_16	1449063.JMLS01000008_gene4915	3.171e-83	286.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,4IURM@91061|Bacilli,277Q7@186822|Paenibacillaceae	91061|Bacilli	S	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_2506219_23	926560.KE387023_gene3409	1.905e-56	205.0	COG1051@1|root,COG1051@2|Bacteria,1WN9T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Hydrolase of X-linked nucleoside diphosphate N terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N
HKD1_k127_2506219_14	1100721.ALKO01000003_gene2553	5e-91	312.0	COG1167@1|root,COG1167@2|Bacteria,1MV6F@1224|Proteobacteria,2VHE6@28216|Betaproteobacteria,4A9JE@80864|Comamonadaceae	28216|Betaproteobacteria	EK	PFAM aminotransferase, class I and II	lysN	-	-	ko:K05825	ko00300,ko01100,ko01130,ko01210,map00300,map01100,map01130,map01210	-	R01939	RC00006	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD1_k127_2506219_20	1499680.CCFE01000011_gene715	3.962e-64	231.0	COG2421@1|root,COG2421@2|Bacteria,1TQ67@1239|Firmicutes,4HA9D@91061|Bacilli,1ZEDI@1386|Bacillus	91061|Bacilli	C	Acetamidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	FmdA_AmdA
HKD1_k127_2506219_26	525254.HMPREF0072_0033	1.635e-17	85.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia,22HW5@1570339|Peptoniphilaceae	186801|Clostridia	L	GIY-YIG catalytic domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HKD1_k127_2506219_6	330214.NIDE4018	1.079e-209	672.0	COG0488@1|root,COG0488@2|Bacteria	2|Bacteria	L	(ABC) transporter	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_2506219_24	1121106.JQKB01000003_gene2609	1.674e-28	119.0	COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,2TUUQ@28211|Alphaproteobacteria,2JRNF@204441|Rhodospirillales	204441|Rhodospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_2508837_1	1123508.JH636454_gene5769	3.461e-77	262.0	COG4422@1|root,COG4422@2|Bacteria,2IY1I@203682|Planctomycetes	203682|Planctomycetes	S	COG4422 Bacteriophage protein gp37	-	-	-	-	-	-	-	-	-	-	-	-	DUF5131
HKD1_k127_2508837_0	383372.Rcas_0928	1.472e-126	419.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_2509309_5	335543.Sfum_3722	4.633e-25	105.0	COG4729@1|root,COG4729@2|Bacteria,1NK52@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
HKD1_k127_2509309_1	401526.TcarDRAFT_1522	1.019e-279	874.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HKD1_k127_2509309_4	1499967.BAYZ01000026_gene1603	1.213e-71	250.0	COG1794@1|root,COG1794@2|Bacteria,2NR05@2323|unclassified Bacteria	2|Bacteria	M	Asp/Glu/Hydantoin racemase	racX	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HKD1_k127_2509309_2	671143.DAMO_1683	1.707e-200	636.0	COG0004@1|root,COG0004@2|Bacteria,2NQS8@2323|unclassified Bacteria	2|Bacteria	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	iHN637.CLJU_c42670,iYO844.BSU36510	Ammonium_transp
HKD1_k127_2509309_0	671143.DAMO_3015	5.68e-286	906.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD1_k127_2509309_3	338963.Pcar_2149	2.381e-118	387.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WIPP@28221|Deltaproteobacteria,43TCZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pilB	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N,cNMP_binding
HKD1_k127_2516533_6	370438.PTH_2894	1.722e-58	212.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,261ZB@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	kduD	-	1.1.1.127,1.1.1.304,1.1.1.69,1.1.1.76	ko:K00046,ko:K00065,ko:K18009	ko00040,ko00650,map00040,map00650	-	R01542,R03707,R09078,R10505	RC00089,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD1_k127_2516533_2	998674.ATTE01000001_gene3216	4.43e-101	336.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RY2T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Dehydrogenase	paaH	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_2516533_4	671143.DAMO_0646	8.11e-83	282.0	COG2086@1|root,COG2086@2|Bacteria,2NP4J@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	ygcR	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0055114	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_2516533_5	671143.DAMO_0647	4.931e-78	279.0	COG2025@1|root,COG2025@2|Bacteria,2NNR6@2323|unclassified Bacteria	2|Bacteria	C	Electron transfer flavoprotein	etfA-5	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD1_k127_2516533_0	671143.DAMO_0649	1.95e-247	779.0	COG0247@1|root,COG0247@2|Bacteria,2NNXS@2323|unclassified Bacteria	2|Bacteria	C	Cysteine-rich domain	dgcB	-	-	ko:K11473,ko:K21834	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,DUF3483,Fer4_8
HKD1_k127_2516533_7	865861.AZSU01000007_gene1073	3.889e-57	201.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,36J94@31979|Clostridiaceae	186801|Clostridia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD1_k127_2516533_3	903814.ELI_0288	3.103e-88	305.0	COG2006@1|root,COG2006@2|Bacteria,1TRYQ@1239|Firmicutes,24966@186801|Clostridia,25X3Z@186806|Eubacteriaceae	186801|Clostridia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_2516533_1	1218074.BAXZ01000004_gene1111	9.051e-112	374.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2WFE1@28216|Betaproteobacteria,1KI13@119060|Burkholderiaceae	28216|Betaproteobacteria	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_2516533_8	742738.HMPREF9460_00657	8.72e-33	132.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,26B72@186813|unclassified Clostridiales	186801|Clostridia	I	N-terminal half of MaoC dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HKD1_k127_2528404_13	1499967.BAYZ01000163_gene6599	9.19e-40	153.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_2528404_16	345341.KUTG_00632	0.0003855	43.0	COG0395@1|root,COG0395@2|Bacteria,2GJ3P@201174|Actinobacteria,4E0TQ@85010|Pseudonocardiales	201174|Actinobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K02026,ko:K17239,ko:K17331	ko02010,map02010	M00207,M00599,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33,3.A.1.1.38	-	-	BPD_transp_1
HKD1_k127_2528404_2	671143.DAMO_0319	1.618e-189	622.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2NP4I@2323|unclassified Bacteria	2|Bacteria	U	Metallo-beta-lactamase superfamily	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD1_k127_2528404_10	671143.DAMO_0315	1.376e-77	276.0	COG0795@1|root,COG0795@2|Bacteria,2NP9S@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ family protein	lptF	-	-	ko:K07091,ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD1_k127_2528404_7	671143.DAMO_0314	2.334e-94	322.0	COG0795@1|root,COG0795@2|Bacteria,2NPHN@2323|unclassified Bacteria	2|Bacteria	S	Permease YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD1_k127_2528404_1	224324.aq_1180	3.518e-190	601.0	COG0499@1|root,COG0499@2|Bacteria,2G3TI@200783|Aquificae	200783|Aquificae	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_2528404_0	671143.DAMO_0276	2.149e-214	670.0	COG0192@1|root,COG0192@2|Bacteria,2NNYF@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	GO:0003674,GO:0003824,GO:0004478,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0016740,GO:0016765,GO:0044424,GO:0044444,GO:0044464	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_2528404_8	78245.Xaut_0008	1.941e-83	286.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TSMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_2528404_9	78245.Xaut_0007	9.199e-79	285.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2TVRQ@28211|Alphaproteobacteria,3F1HX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_2528404_5	391735.Veis_0897	1.432e-124	407.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,2VIFR@28216|Betaproteobacteria,4AHPH@80864|Comamonadaceae	28216|Betaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_2528404_6	78245.Xaut_0005	8.852e-105	353.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3F1D1@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_2528404_4	78245.Xaut_0004	1.032e-157	508.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,3F1AA@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_2528404_3	1125863.JAFN01000001_gene893	5.511e-178	576.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,42P77@68525|delta/epsilon subdivisions,2WK7E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.1.202,2.7.3.9	ko:K02768,ko:K08483,ko:K11183	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1,8.A.7	-	-	EIIA-man,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C,PTS-HPr
HKD1_k127_2528404_11	1131269.AQVV01000015_gene2041	8.345e-60	222.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	rfaG	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_2528404_14	768670.Calni_1965	1.879e-24	113.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23
HKD1_k127_2528404_12	335543.Sfum_0371	2.465e-52	199.0	COG0859@1|root,COG0859@2|Bacteria,1N112@1224|Proteobacteria,42MUI@68525|delta/epsilon subdivisions,2WRZM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	PFAM glycosyl transferase family 9	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_2548323_0	335543.Sfum_0432	9.415e-198	625.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,42M08@68525|delta/epsilon subdivisions,2WITS@28221|Deltaproteobacteria,2MR4G@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,PurS
HKD1_k127_2548323_1	933262.AXAM01000073_gene3359	1.718e-109	368.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,42MNY@68525|delta/epsilon subdivisions,2WJ6C@28221|Deltaproteobacteria,2MI5J@213118|Desulfobacterales	28221|Deltaproteobacteria	F	CobB/CobQ-like glutamine amidotransferase domain	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_2548323_2	1122947.FR7_1323	2.439e-05	47.0	COG2049@1|root,COG2049@2|Bacteria,1TTBZ@1239|Firmicutes,4H3CN@909932|Negativicutes	909932|Negativicutes	E	Allophanate hydrolase subunit 1	-	-	-	ko:K06351	-	-	-	-	ko00000	-	-	-	CT_C_D
HKD1_k127_2551080_5	330214.NIDE3598	1.077e-151	484.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD1_k127_2551080_16	497321.C664_06868	2.051e-57	205.0	COG2010@1|root,COG2010@2|Bacteria,1N0EF@1224|Proteobacteria,2VT6G@28216|Betaproteobacteria,2KYSG@206389|Rhodocyclales	206389|Rhodocyclales	C	Cytochrome c mono- and diheme variants	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2551080_15	945713.IALB_2899	8.036e-58	205.0	28NYH@1|root,2ZBVN@2|Bacteria	2|Bacteria	S	Belongs to the UPF0403 family	yqiW	-	-	-	-	-	-	-	-	-	-	-	Disulph_isomer
HKD1_k127_2551080_0	926550.CLDAP_36510	2.204e-251	786.0	COG3534@1|root,COG3534@2|Bacteria,2G63U@200795|Chloroflexi	2|Bacteria	G	PFAM alpha-L-arabinofuranosidase domain protein	abfA	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HKD1_k127_2551080_17	661478.OP10G_2210	8.892e-43	173.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_2551080_11	525904.Tter_2208	9.893e-72	252.0	COG1175@1|root,COG1175@2|Bacteria,2NPDA@2323|unclassified Bacteria	2|Bacteria	G	binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K05814,ko:K10118,ko:K10237,ko:K10241,ko:K15771,ko:K17235,ko:K17316	ko02010,map02010	M00196,M00198,M00204,M00206,M00207,M00491,M00602,M00605	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.17,3.A.1.1.2,3.A.1.1.23,3.A.1.1.24,3.A.1.1.28,3.A.1.1.3,3.A.1.1.30,3.A.1.1.34	-	-	BPD_transp_1
HKD1_k127_2551080_14	1195236.CTER_1192	6.933e-62	224.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,25C50@186801|Clostridia,3WSB2@541000|Ruminococcaceae	186801|Clostridia	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2551080_10	1123504.JQKD01000002_gene4000	2.277e-96	325.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2VN73@28216|Betaproteobacteria,4ADBZ@80864|Comamonadaceae	28216|Betaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_2551080_8	1121106.JQKB01000032_gene4428	1.033e-116	384.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,2JPTF@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_2551080_7	1205680.CAKO01000029_gene5024	4.7e-137	456.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2TXJS@28211|Alphaproteobacteria,2JVHA@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_2551080_19	1209984.BN978_03698	5.362e-37	152.0	COG2186@1|root,COG2186@2|Bacteria,2I90D@201174|Actinobacteria,236Z8@1762|Mycobacteriaceae	201174|Actinobacteria	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_2551080_20	113395.AXAI01000021_gene3519	2.056e-08	62.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2TVAB@28211|Alphaproteobacteria,3JUMP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_2551080_2	706587.Desti_4722	3.951e-169	550.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD1_k127_2551080_21	485913.Krac_7836	2.606e-07	56.0	COG1960@1|root,COG1960@2|Bacteria,2G7JH@200795|Chloroflexi	200795|Chloroflexi	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_2551080_6	96561.Dole_2972	2.524e-149	487.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42P1P@68525|delta/epsilon subdivisions,2WJ99@28221|Deltaproteobacteria,2MJA4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TAT_signal,TPR_16,TPR_19
HKD1_k127_2551080_13	196367.JNFG01000042_gene7862	1.681e-64	227.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VJC7@28216|Betaproteobacteria,1K2SW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD1_k127_2551080_18	1218075.BAYA01000014_gene4068	2.1e-38	148.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,2VJC7@28216|Betaproteobacteria,1K2SW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD1_k127_2551080_4	671143.DAMO_3028	3.645e-152	492.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	egtB	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	DinB_2,FGE-sulfatase
HKD1_k127_2551080_12	1123504.JQKD01000007_gene3396	4.541e-71	251.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2VJHK@28216|Betaproteobacteria,4AB1Q@80864|Comamonadaceae	28216|Betaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD1_k127_2551080_9	220664.PFL_2851	7.058e-114	382.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria	1224|Proteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2551080_1	398767.Glov_0712	1.571e-174	553.0	COG0371@1|root,COG0371@2|Bacteria,1MWAE@1224|Proteobacteria,42PJS@68525|delta/epsilon subdivisions,2WJ69@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.6	ko:K00005	ko00561,ko00640,ko01100,map00561,map00640,map01100	-	R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_2551080_3	1038859.AXAU01000010_gene1766	7.363e-156	495.0	COG3618@1|root,COG3618@2|Bacteria,1R4T9@1224|Proteobacteria,2TRFM@28211|Alphaproteobacteria,3JX2A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_2561029_0	1532558.JL39_23420	4.692e-90	306.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRJI@28211|Alphaproteobacteria,4BAQP@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K15585	ko02010,map02010	M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_2561029_1	1200792.AKYF01000010_gene2141	1.49e-84	289.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HDBB@91061|Bacilli,274T8@186822|Paenibacillaceae	91061|Bacilli	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_2562968_1	243231.GSU1866	8.486e-91	303.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,42MK9@68525|delta/epsilon subdivisions,2WJ1C@28221|Deltaproteobacteria,43UHM@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	SMART Nucleotide binding protein, PINc	phoH1	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD1_k127_2562968_0	671143.DAMO_1991	9.658e-289	897.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	GO:0003674,GO:0003824,GO:0004360,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006002,GO:0006040,GO:0006047,GO:0006139,GO:0006464,GO:0006486,GO:0006487,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009100,GO:0009101,GO:0009225,GO:0009987,GO:0016740,GO:0016769,GO:0019538,GO:0019637,GO:0034641,GO:0034645,GO:0036211,GO:0043170,GO:0043412,GO:0043413,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0055086,GO:0070085,GO:0070548,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_1487	GATase_6,SIS
HKD1_k127_2579183_0	1380394.JADL01000001_gene2217	8.453e-275	862.0	COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQRE@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_258204_2	649747.HMPREF0083_02915	1.236e-93	314.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,4H9QK@91061|Bacilli,275V3@186822|Paenibacillaceae	91061|Bacilli	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_258204_0	1121468.AUBR01000014_gene2192	1.485e-131	435.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,42FK5@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_258204_1	869210.Marky_1469	1.351e-99	329.0	COG1126@1|root,COG1126@2|Bacteria,1WI0Q@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	ABC-type polar amino acid transport system ATPase component	-	-	-	ko:K09972	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
HKD1_k127_258204_8	1131814.JAFO01000001_gene2608	1.761e-40	158.0	COG0765@1|root,COG0765@2|Bacteria,1MVB6@1224|Proteobacteria,2U0HN@28211|Alphaproteobacteria,3F0MW@335928|Xanthobacteraceae	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD1_k127_258204_6	34007.IT40_16555	2.459e-47	178.0	COG0765@1|root,COG0765@2|Bacteria,1MX2Y@1224|Proteobacteria,2U5MI@28211|Alphaproteobacteria,2PVE4@265|Paracoccus	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD1_k127_258204_5	1169143.KB911049_gene5551	1.229e-47	182.0	COG0834@1|root,COG0834@2|Bacteria,1MVMP@1224|Proteobacteria,2WEI7@28216|Betaproteobacteria,1K3Y0@119060|Burkholderiaceae	28216|Betaproteobacteria	ET	belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_258204_9	1394178.AWOO02000001_gene1334	1.54e-29	129.0	COG1802@1|root,COG1802@2|Bacteria,2GMJX@201174|Actinobacteria,4EH5I@85012|Streptosporangiales	201174|Actinobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_258204_3	243231.GSU0520	9.921e-86	304.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,42P4E@68525|delta/epsilon subdivisions,2WN09@28221|Deltaproteobacteria,43SVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0016070,GO:0016853,GO:0016866,GO:0034641,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
HKD1_k127_258204_7	864051.BurJ1DRAFT_4437	7.104e-43	169.0	COG0697@1|root,COG0697@2|Bacteria,1R46X@1224|Proteobacteria,2VNGN@28216|Betaproteobacteria,1KNKQ@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_258204_4	1444309.JAQG01000097_gene4122	1.895e-69	251.0	COG2220@1|root,COG2220@2|Bacteria,1TRRP@1239|Firmicutes,4HA5C@91061|Bacilli,275MX@186822|Paenibacillaceae	91061|Bacilli	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_258204_10	298653.Franean1_4571	8.723e-07	59.0	COG1028@1|root,COG1028@2|Bacteria,2HP88@201174|Actinobacteria	201174|Actinobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2601161_2	573413.Spirs_3457	1.121e-28	119.0	COG1028@1|root,COG1028@2|Bacteria,2J8GM@203691|Spirochaetes	203691|Spirochaetes	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_2601161_0	457415.HMPREF1006_01991	9.36e-101	338.0	COG2309@1|root,COG2309@2|Bacteria,3TC7X@508458|Synergistetes	508458|Synergistetes	E	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2601161_1	42256.RradSPS_1685	6.431e-36	143.0	COG0436@1|root,COG0436@2|Bacteria,2GJ7R@201174|Actinobacteria,4CTDV@84995|Rubrobacteria	84995|Rubrobacteria	E	Aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_2611357_3	671143.DAMO_3057	4.523e-42	162.0	COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD1_k127_2611357_1	646529.Desaci_0664	1.524e-67	233.0	COG4803@1|root,COG4803@2|Bacteria,1UJ40@1239|Firmicutes,24JIS@186801|Clostridia	186801|Clostridia	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269,YflT
HKD1_k127_2611357_2	573370.DMR_11930	3.278e-67	232.0	COG4803@1|root,COG4803@2|Bacteria,1RAJ2@1224|Proteobacteria,42RBR@68525|delta/epsilon subdivisions,2WN5K@28221|Deltaproteobacteria,2MAEW@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
HKD1_k127_2611357_4	522306.CAP2UW1_1519	1.183e-31	131.0	COG4828@1|root,COG4828@2|Bacteria,1N984@1224|Proteobacteria,2W60I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD1_k127_2611357_5	207559.Dde_2000	1.118e-09	66.0	COG2823@1|root,COG2823@2|Bacteria,1NB3W@1224|Proteobacteria,42T8P@68525|delta/epsilon subdivisions,2WR4I@28221|Deltaproteobacteria,2MC5K@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM transport-associated	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HKD1_k127_2611357_0	1304872.JAGC01000009_gene1532	6.907e-119	387.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,42PRE@68525|delta/epsilon subdivisions,2WJRD@28221|Deltaproteobacteria,2MAAB@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_2618170_2	189753.AXAS01000033_gene2858	5.109e-39	149.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,2TTSG@28211|Alphaproteobacteria,3JRZP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_2618170_4	1206731.BAGB01000063_gene7437	8.527e-36	138.0	COG2350@1|root,COG2350@2|Bacteria,2GS0M@201174|Actinobacteria,4G4G4@85025|Nocardiaceae	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD1_k127_2618170_1	1038866.KB902774_gene2219	1.421e-50	185.0	2ERSM@1|root,33JBU@2|Bacteria,1R78D@1224|Proteobacteria,2U0HU@28211|Alphaproteobacteria,3JVSB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2618170_0	1123393.KB891317_gene2209	1.015e-59	213.0	COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria	1224|Proteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2618170_3	1082933.MEA186_02043	6.451e-37	144.0	COG4319@1|root,COG4319@2|Bacteria,1NH3X@1224|Proteobacteria,2VGUW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_2635294_2	706587.Desti_2685	2.381e-173	552.0	COG2421@1|root,COG2421@2|Bacteria,1N12N@1224|Proteobacteria,42WG0@68525|delta/epsilon subdivisions,2WSEJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Acetamidase/Formamidase family	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HKD1_k127_2635294_17	1235797.C816_00187	7.104e-29	122.0	COG1661@1|root,COG1661@2|Bacteria,1V67W@1239|Firmicutes,24J3Y@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
HKD1_k127_2635294_7	1121440.AUMA01000009_gene671	1.025e-95	325.0	COG0500@1|root,COG0500@2|Bacteria,1QW86@1224|Proteobacteria,42N1Q@68525|delta/epsilon subdivisions,2WJJS@28221|Deltaproteobacteria,2MA1B@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	O-methyltransferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_2635294_12	671143.DAMO_2754	2.284e-41	161.0	COG1579@1|root,COG1579@2|Bacteria,2NPW0@2323|unclassified Bacteria	2|Bacteria	S	C4-type zinc ribbon domain	CP_0228	-	3.5.4.16	ko:K07164,ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	zf-RING_7
HKD1_k127_2635294_14	867903.ThesuDRAFT_00795	2.069e-38	152.0	COG0328@1|root,COG2384@1|root,COG0328@2|Bacteria,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,3WDGE@538999|Clostridiales incertae sedis	186801|Clostridia	L	tRNA (adenine(22)-N(1))-methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
HKD1_k127_2635294_19	338966.Ppro_1102	1.737e-12	74.0	COG5512@1|root,COG5512@2|Bacteria,1N6KK@1224|Proteobacteria,42TK4@68525|delta/epsilon subdivisions,2WQQS@28221|Deltaproteobacteria,43VF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD1_k127_2635294_6	671143.DAMO_2751	1.55e-110	369.0	COG0774@1|root,COG0774@2|Bacteria,2NNYX@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008270,GO:0008610,GO:0008654,GO:0008759,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016787,GO:0016810,GO:0016811,GO:0019213,GO:0019637,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044464,GO:0046467,GO:0046493,GO:0046872,GO:0046914,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	3.5.1.108,4.2.1.59	ko:K02535,ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	iECS88_1305.ECS88_0100	LpxC
HKD1_k127_2635294_3	243231.GSU0812	1.558e-171	567.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,42MCN@68525|delta/epsilon subdivisions,2WIYA@28221|Deltaproteobacteria,43TNJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD1_k127_2635294_1	1499967.BAYZ01000008_gene5424	2.903e-175	569.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	ntrX	-	-	ko:K02481,ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_2635294_15	255470.cbdbA344	5.978e-36	145.0	COG0637@1|root,COG1214@1|root,COG0637@2|Bacteria,COG1214@2|Bacteria,2G6ZZ@200795|Chloroflexi,34D2B@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Glycoprotease family	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Peptidase_M22
HKD1_k127_2635294_8	204669.Acid345_2245	3.09e-91	320.0	COG0053@1|root,COG0053@2|Bacteria,3Y43E@57723|Acidobacteria,2JIIM@204432|Acidobacteriia	204432|Acidobacteriia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD1_k127_2635294_10	1234664.AMRO01000074_gene2886	4.981e-62	230.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,4H9Q7@91061|Bacilli,1WEUF@129337|Geobacillus	91061|Bacilli	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD1_k127_2635294_5	667014.Thein_2035	3.712e-113	372.0	COG1313@1|root,COG1313@2|Bacteria,2GH0B@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	C	Radical SAM superfamily	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD1_k127_2635294_0	671143.DAMO_2750	5.338e-225	711.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,2NNNK@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase X family	polX	-	-	ko:K02347,ko:K04477	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD1_k127_2635294_20	694429.Pyrfu_1736	0.0004207	45.0	COG1801@1|root,arCOG04291@2157|Archaea,2XQ8C@28889|Crenarchaeota	28889|Crenarchaeota	S	DUF72 domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_2635294_9	909663.KI867150_gene313	8.584e-65	230.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,42RV4@68525|delta/epsilon subdivisions,2WP4W@28221|Deltaproteobacteria,2MRS3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_2635294_4	360910.BAV0776	6.836e-168	547.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VZ4T@28216|Betaproteobacteria,3T5GW@506|Alcaligenaceae	28216|Betaproteobacteria	E	Gamma-glutamyltranspeptidase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_2635294_11	1121861.KB899910_gene762	4.374e-48	191.0	COG3342@1|root,COG3342@2|Bacteria,1MWQT@1224|Proteobacteria,2TRJZ@28211|Alphaproteobacteria,2JS5D@204441|Rhodospirillales	204441|Rhodospirillales	S	Family of unknown function (DUF1028)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1028
HKD1_k127_2635294_16	316067.Geob_2074	1.337e-34	137.0	COG1569@1|root,COG1569@2|Bacteria,1QSUM@1224|Proteobacteria,42WJR@68525|delta/epsilon subdivisions,2WRT9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HKD1_k127_2635294_18	944480.ATUV01000002_gene422	5.144e-20	93.0	COG4118@1|root,COG4118@2|Bacteria,1NM68@1224|Proteobacteria,42XA0@68525|delta/epsilon subdivisions,2WT8W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_2635294_13	869210.Marky_2238	1.586e-39	148.0	COG1173@1|root,COG1173@2|Bacteria,1WJC3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_2639733_5	521011.Mpal_2322	9.296e-12	70.0	COG2217@1|root,arCOG01576@2157|Archaea,2XTD8@28890|Euryarchaeota,2N9FY@224756|Methanomicrobia	224756|Methanomicrobia	P	E1-E2 ATPase	-	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_2639733_3	118166.JH976537_gene4139	1.108e-22	103.0	COG1937@1|root,COG1937@2|Bacteria,1G6NF@1117|Cyanobacteria,1HBHM@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Uncharacterised BCR, COG1937	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD1_k127_2639733_6	1121121.KB894317_gene4216	1.268e-09	64.0	COG0582@1|root,COG0582@2|Bacteria,1TTJI@1239|Firmicutes,4IQMM@91061|Bacilli,276FC@186822|Paenibacillaceae	91061|Bacilli	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_2639733_2	234267.Acid_4808	1.18e-54	205.0	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
HKD1_k127_2639733_1	1211115.ALIQ01000174_gene3538	2.501e-122	398.0	COG0395@1|root,COG0395@2|Bacteria,1MXTE@1224|Proteobacteria,2TSM4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2639733_0	1211115.ALIQ01000174_gene3539	1.035e-122	400.0	COG1175@1|root,COG1175@2|Bacteria,1RDF1@1224|Proteobacteria,2U92C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2639733_4	1211115.ALIQ01000174_gene3540	2.035e-21	94.0	COG1653@1|root,COG1653@2|Bacteria,1R767@1224|Proteobacteria,2U1C0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_2658226_2	316067.Geob_2357	1.255e-77	274.0	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria,43T76@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2658226_0	56780.SYN_00023	9.362e-165	526.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2MQUU@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2658226_1	443144.GM21_0987	1.232e-78	266.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42QF5@68525|delta/epsilon subdivisions,2WK2K@28221|Deltaproteobacteria,43TRN@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2702714_1	1304885.AUEY01000001_gene3209	8.137e-107	352.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,42M2I@68525|delta/epsilon subdivisions,2WMSH@28221|Deltaproteobacteria,2MPU8@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_2702714_4	1089548.KI783301_gene1145	9.907e-28	120.0	COG0500@1|root,COG2226@2|Bacteria,1V0C5@1239|Firmicutes,4HGC7@91061|Bacilli	91061|Bacilli	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_2702714_6	671143.DAMO_2997	2.013e-14	76.0	COG4395@1|root,COG4395@2|Bacteria	2|Bacteria	S	Tim44	MA20_08550	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	Tim44
HKD1_k127_2702714_5	338966.Ppro_0435	1.844e-24	110.0	COG2204@1|root,COG2204@2|Bacteria,1RKC4@1224|Proteobacteria,42SJ3@68525|delta/epsilon subdivisions,2WPI1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_2702714_2	1382356.JQMP01000001_gene844	1.232e-70	252.0	COG0265@1|root,COG0265@2|Bacteria,2G8RK@200795|Chloroflexi,27Y6G@189775|Thermomicrobia	189775|Thermomicrobia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_2702714_0	661478.OP10G_0423	0.0	1039.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_2702714_3	102129.Lepto7375DRAFT_5415	1.184e-69	258.0	COG0845@1|root,COG0845@2|Bacteria,1G1I8@1117|Cyanobacteria,1HEB7@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23,YtkA
HKD1_k127_2702714_7	1185876.BN8_06006	1.542e-13	83.0	COG1538@1|root,COG1538@2|Bacteria,4NF4X@976|Bacteroidetes,47KE9@768503|Cytophagia	976|Bacteroidetes	MU	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_2702714_8	311402.Avi_0942	4.782e-09	63.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,4B8TR@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	FOG TPR repeat	MA20_42300	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HKD1_k127_2722589_1	290397.Adeh_0218	8.187e-71	244.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1149@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1149@2|Bacteria,1MVM0@1224|Proteobacteria,42MZ0@68525|delta/epsilon subdivisions,2WJ96@28221|Deltaproteobacteria,2Z2NY@29|Myxococcales	28221|Deltaproteobacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	poR	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_2722589_3	1123508.JH636448_gene7658	3.332e-07	62.0	COG3118@1|root,COG3118@2|Bacteria,2J08Q@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_2722589_0	1403819.BATR01000195_gene6595	1.885e-136	455.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_2722589_2	1267534.KB906756_gene611	6.805e-16	82.0	COG2267@1|root,COG2267@2|Bacteria,3Y4GV@57723|Acidobacteria,2JJ2R@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_2746764_2	522306.CAP2UW1_1267	1.417e-31	130.0	2EBP0@1|root,335P6@2|Bacteria,1N33Y@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2746764_0	1395516.PMO01_14390	3.781e-194	635.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,1T5GM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2746764_1	1298864.AUEQ01000007_gene1926	1.594e-83	281.0	COG1502@1|root,COG1502@2|Bacteria,2HA2M@201174|Actinobacteria,232YH@1762|Mycobacteriaceae	201174|Actinobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD1_k127_2749670_7	118168.MC7420_4324	3.223e-43	168.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1H8AU@1150|Oscillatoriales	1117|Cyanobacteria	IQ	with different specificities (related to short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2749670_10	266265.Bxe_C0610	8.984e-08	57.0	COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2W6SY@28216|Betaproteobacteria,1KCJX@119060|Burkholderiaceae	28216|Betaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2749670_2	1429916.X566_14890	1.686e-137	444.0	COG0179@1|root,COG0179@2|Bacteria,1R7SI@1224|Proteobacteria,2VFC0@28211|Alphaproteobacteria,3K3FV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_2749670_5	314232.SKA53_00699	8.359e-108	356.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2TSAS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_2749670_3	398580.Dshi_2544	1.266e-112	372.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TS9K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_2749670_4	501479.ACNW01000121_gene3053	2.872e-111	369.0	COG0715@1|root,COG0715@2|Bacteria,1R60E@1224|Proteobacteria,2U09M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC transporter (Periplasmic binding protein)	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_2749670_1	1047013.AQSP01000091_gene644	9.813e-244	762.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
HKD1_k127_2749670_6	1047013.AQSP01000091_gene643	2.56e-75	259.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
HKD1_k127_2749670_0	1499967.BAYZ01000059_gene4772	0.0	1064.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.12.1.3	ko:K18331	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
HKD1_k127_2777086_2	644282.Deba_1291	2.578e-30	122.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	acyl-coa dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_2777086_1	1121405.dsmv_0918	9.737e-95	319.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,42QPM@68525|delta/epsilon subdivisions,2WMRG@28221|Deltaproteobacteria,2MI75@213118|Desulfobacterales	28221|Deltaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1716	ECH_1
HKD1_k127_2777086_0	644966.Tmar_1237	1.025e-112	375.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes	1239|Firmicutes	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_2777086_3	330214.NIDE2547	4.425e-11	67.0	COG1912@1|root,COG1912@2|Bacteria,3J0RG@40117|Nitrospirae	40117|Nitrospirae	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD1_k127_2800589_1	99598.Cal7507_2656	6.681e-29	118.0	COG0144@1|root,COG0144@2|Bacteria,1G4U9@1117|Cyanobacteria,1HT5Q@1161|Nostocales	1117|Cyanobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD1_k127_2800589_2	234267.Acid_0644	7.175e-23	108.0	COG3464@1|root,COG3464@2|Bacteria	234267.Acid_0644|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2800589_0	1380394.JADL01000008_gene3577	2.223e-188	600.0	COG0665@1|root,COG0665@2|Bacteria,1MVGP@1224|Proteobacteria,2TUMK@28211|Alphaproteobacteria,2JPB1@204441|Rhodospirillales	204441|Rhodospirillales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD1_k127_2800589_3	1205680.CAKO01000038_gene1979	1.565e-21	98.0	COG1177@1|root,COG1177@2|Bacteria,1MUQD@1224|Proteobacteria,2TS3C@28211|Alphaproteobacteria,2JVVN@204441|Rhodospirillales	204441|Rhodospirillales	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_2818186_18	1028801.RG1141_PA09730	1.096e-34	148.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria,4BMAR@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2818186_7	1209989.TepiRe1_2255	4.99e-78	272.0	COG1175@1|root,COG1175@2|Bacteria,1TTAF@1239|Firmicutes,24AMT@186801|Clostridia,42FWJ@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_2818186_13	1121346.KB899809_gene3762	3.93e-50	196.0	COG1653@1|root,COG1653@2|Bacteria,1TPX9@1239|Firmicutes,4HI13@91061|Bacilli,276C3@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_2818186_10	309799.DICTH_0482	1.195e-62	226.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD1_k127_2818186_17	1242864.D187_000919	1e-39	157.0	COG2802@1|root,COG2802@2|Bacteria,1Q90Z@1224|Proteobacteria,43426@68525|delta/epsilon subdivisions,2X4S2@28221|Deltaproteobacteria,2YVIH@29|Myxococcales	28221|Deltaproteobacteria	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338,ko:K07157	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD1_k127_2818186_8	485913.Krac_7281	2.346e-77	267.0	COG1028@1|root,COG1028@2|Bacteria,2G6GQ@200795|Chloroflexi	200795|Chloroflexi	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100,1.1.1.140	ko:K00059,ko:K00068	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05607,R07759,R07763,R10116,R10120,R11671	RC00029,RC00085,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_2818186_12	118168.MC7420_4324	3.338e-60	218.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1H8AU@1150|Oscillatoriales	1117|Cyanobacteria	IQ	with different specificities (related to short-chain alcohol	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2818186_4	1120954.ATXE01000002_gene987	9.607e-89	307.0	COG0524@1|root,COG0524@2|Bacteria,2HZSG@201174|Actinobacteria,4DTV3@85009|Propionibacteriales	201174|Actinobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD1_k127_2818186_21	314230.DSM3645_21754	1.299e-11	75.0	COG0800@1|root,COG0800@2|Bacteria,2IXBP@203682|Planctomycetes	203682|Planctomycetes	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HKD1_k127_2818186_11	420247.Msm_0518	6.447e-62	226.0	COG0407@1|root,arCOG03324@2157|Archaea,2XVT1@28890|Euryarchaeota,23PXK@183925|Methanobacteria	183925|Methanobacteria	H	Methyltransferase MtaA	-	-	2.1.1.246	ko:K14080	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R09098,R10000	RC00035,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_2818186_16	1210884.HG799463_gene10006	4.028e-40	157.0	COG0684@1|root,COG0684@2|Bacteria,2IY7W@203682|Planctomycetes	203682|Planctomycetes	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD1_k127_2818186_9	1294265.JCM21738_446	1.878e-68	243.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,4HB9E@91061|Bacilli,1ZCCD@1386|Bacillus	91061|Bacilli	K	RpiR family transcriptional regulator	gntR	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD1_k127_2818186_15	1265502.KB905970_gene1295	3.882e-40	154.0	COG3090@1|root,COG3090@2|Bacteria,1RAZ5@1224|Proteobacteria,2VQ8J@28216|Betaproteobacteria,4ADJZ@80864|Comamonadaceae	28216|Betaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctQ	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_2818186_0	1265502.KB905970_gene1296	7.044e-158	508.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2VHJP@28216|Betaproteobacteria,4ACPD@80864|Comamonadaceae	28216|Betaproteobacteria	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_2818186_1	1265502.KB905970_gene1297	4.182e-155	497.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2VHPJ@28216|Betaproteobacteria,4AGXE@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_2818186_14	66692.ABC3607	3.89e-47	182.0	COG0329@1|root,COG0329@2|Bacteria,1TSEN@1239|Firmicutes,4I3K0@91061|Bacilli,1ZHGD@1386|Bacillus	91061|Bacilli	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_2818186_2	1499967.BAYZ01000014_gene6362	3.366e-141	469.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	gntK	-	2.7.1.12,2.7.1.17	ko:K00851,ko:K00854	ko00030,ko00040,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_2818186_6	1449126.JQKL01000019_gene3205	4.013e-81	281.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,269C3@186813|unclassified Clostridiales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_2818186_19	1118054.CAGW01000033_gene4063	1.507e-26	115.0	COG3090@1|root,COG3090@2|Bacteria,1V8BR@1239|Firmicutes,4HSSR@91061|Bacilli	91061|Bacilli	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_2818186_3	665959.HMPREF1013_01360	2.067e-111	374.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,1ZC02@1386|Bacillus	91061|Bacilli	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	ko:K21393	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctM
HKD1_k127_2818186_20	1121861.KB899913_gene2193	2.598e-14	78.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD1_k127_2818186_5	1499967.BAYZ01000014_gene6363	5.214e-82	283.0	COG0111@1|root,COG0111@2|Bacteria,2NQWB@2323|unclassified Bacteria	2|Bacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iLJ478.TM0327	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_2826826_13	1499967.BAYZ01000186_gene3970	2.217e-60	218.0	COG0438@1|root,COG0438@2|Bacteria,2NR2T@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_2826826_6	555088.DealDRAFT_1940	8.948e-101	339.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,42KNT@68298|Syntrophomonadaceae	186801|Clostridia	M	Male sterility protein	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_2826826_12	1128421.JAGA01000003_gene2785	1.798e-61	226.0	COG0472@1|root,COG0472@2|Bacteria,2NR03@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	CoA_binding_3,Glycos_transf_4
HKD1_k127_2826826_16	264732.Moth_0535	1.565e-52	192.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,42GIM@68295|Thermoanaerobacterales	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD1_k127_2826826_15	671143.DAMO_1093	5.07e-56	204.0	COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HKD1_k127_2826826_17	671143.DAMO_1094	3.566e-42	158.0	COG0848@1|root,COG0848@2|Bacteria,2NPWJ@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HKD1_k127_2826826_8	330214.NIDE4106	3.135e-74	256.0	COG0586@1|root,COG0586@2|Bacteria	2|Bacteria	S	FtsZ-dependent cytokinesis	dedA	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_2826826_14	671143.DAMO_1095	5.406e-60	213.0	COG1392@1|root,COG1392@2|Bacteria,2NPPV@2323|unclassified Bacteria	2|Bacteria	P	Protein of unknown function DUF47	MA20_27875	-	-	ko:K02039,ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD1_k127_2826826_22	671143.DAMO_1097	6.673e-13	76.0	COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_2826826_7	671143.DAMO_1098	1.865e-83	290.0	COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_2826826_11	311424.DhcVS_538	1.021e-64	227.0	COG0311@1|root,COG0311@2|Bacteria,2G6JN@200795|Chloroflexi,34D43@301297|Dehalococcoidia	301297|Dehalococcoidia	F	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HKD1_k127_2826826_1	243164.DET0380	1.129e-143	464.0	COG0214@1|root,COG0214@2|Bacteria,2G5MW@200795|Chloroflexi,34D6P@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HKD1_k127_2826826_0	404589.Anae109_0573	1.99e-271	854.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,2YUAP@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_2826826_20	469383.Cwoe_4928	2.159e-20	97.0	COG2062@1|root,COG2062@2|Bacteria,2HPES@201174|Actinobacteria,4CQT1@84995|Rubrobacteria	84995|Rubrobacteria	T	Phosphoglycerate mutase family	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD1_k127_2826826_10	269799.Gmet_2705	3.542e-72	251.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WMS0@28221|Deltaproteobacteria,43TYN@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Plays a role in the regulation of phosphate uptake	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_2826826_4	644966.Tmar_1646	1.57e-104	354.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,3WCRK@538999|Clostridiales incertae sedis	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_2826826_5	404380.Gbem_1851	1.399e-101	340.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,42N2N@68525|delta/epsilon subdivisions,2WK67@28221|Deltaproteobacteria,43VF5@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iAF987.Gmet_2702	BPD_transp_1
HKD1_k127_2826826_3	1191523.MROS_2640	4.285e-125	410.0	COG0226@1|root,COG0226@2|Bacteria	2|Bacteria	P	phosphate ion binding	pstS	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009314,GO:0009628,GO:0009987,GO:0010921,GO:0015698,GO:0019220,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031975,GO:0033554,GO:0035303,GO:0042301,GO:0042597,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0065007,GO:0065009	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iECH74115_1262.ECH74115_5157,iECSP_1301.ECSP_4770,iECs_1301.ECs4664,iG2583_1286.G2583_4518,iZ_1308.Z5219	PBP_like_2
HKD1_k127_2826826_2	671143.DAMO_1128	1.458e-126	426.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	phoR	-	2.7.13.3	ko:K02484,ko:K07636,ko:K07768	ko02020,map02020	M00434,M00443	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HKD1_k127_2826826_9	498761.HM1_2078	2.381e-72	252.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia	186801|Clostridia	K	response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2826826_21	247490.KSU1_B0721	2.744e-18	89.0	COG2005@1|root,COG2005@2|Bacteria,2J0YV@203682|Planctomycetes	203682|Planctomycetes	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1
HKD1_k127_2826826_19	671143.DAMO_1132	6.991e-29	119.0	COG2998@1|root,COG2998@2|Bacteria,2NP4U@2323|unclassified Bacteria	2|Bacteria	H	PBP superfamily domain	tupB	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_2848826_4	1245469.S58_15420	4.9e-08	60.0	COG0477@1|root,COG2814@2|Bacteria,1MVQQ@1224|Proteobacteria,2TRBF@28211|Alphaproteobacteria,3JXPV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K08195	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,MFS_4
HKD1_k127_2848826_2	314254.OA2633_09474	3.555e-83	283.0	COG0693@1|root,COG0693@2|Bacteria,1N8N6@1224|Proteobacteria,2TT0U@28211|Alphaproteobacteria,43XK4@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	intracellular protease amidase	-	-	4.2.1.103	ko:K18199	ko00930,map00930	-	R05771	RC01467	ko00000,ko00001,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_2848826_3	485915.Dret_2496	1.357e-20	100.0	2BHAV@1|root,32BCF@2|Bacteria,1NDPS@1224|Proteobacteria,42SQW@68525|delta/epsilon subdivisions,2WSCF@28221|Deltaproteobacteria,2MD3R@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2848826_1	65497.JODV01000004_gene1420	5.763e-102	343.0	COG0624@1|root,COG0800@1|root,COG0624@2|Bacteria,COG0800@2|Bacteria,2I8IJ@201174|Actinobacteria,4E1MS@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_2867166_1	247490.KSU1_C1386	1.014e-50	186.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K20543,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	1.B.55.3	-	-	Lip_A_acyltrans,TPR_19
HKD1_k127_2867166_0	204669.Acid345_0802	8.69e-172	554.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	2|Bacteria	S	Radical SAM	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_2867166_2	941449.dsx2_0207	1.24e-09	69.0	COG2834@1|root,COG2834@2|Bacteria,1PDTV@1224|Proteobacteria,42TAB@68525|delta/epsilon subdivisions,2WPXY@28221|Deltaproteobacteria,2MA72@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD1_k127_2867166_3	289376.THEYE_A1675	1.899e-08	57.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
HKD1_k127_2869787_2	311402.Avi_0549	2.55e-13	71.0	COG3293@1|root,COG3293@2|Bacteria,1N1CW@1224|Proteobacteria,2U8KW@28211|Alphaproteobacteria,4BFMC@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DUF4096
HKD1_k127_2869787_0	1120956.JHZK01000057_gene1844	6.419e-105	350.0	COG2801@1|root,COG2801@2|Bacteria,1R471@1224|Proteobacteria,2U60M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
HKD1_k127_2869787_1	1121106.JQKB01000071_gene860	3.941e-33	132.0	2DTBN@1|root,33JKH@2|Bacteria,1NNEI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28
HKD1_k127_2877526_1	671143.DAMO_0414	6.961e-93	319.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_2877526_0	335543.Sfum_2617	1.902e-201	634.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,42NZF@68525|delta/epsilon subdivisions,2WJNR@28221|Deltaproteobacteria,2MQ4A@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Osmosensitive K channel His kinase sensor	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	KdpD,PTS_EIIA_2,Usp
HKD1_k127_2877526_2	335543.Sfum_2618	4.743e-53	189.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,42SC9@68525|delta/epsilon subdivisions,2WPDZ@28221|Deltaproteobacteria,2MQQ6@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD1_k127_2882528_0	1379698.RBG1_1C00001G0607	1.712e-147	496.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_2882528_2	234267.Acid_4535	4.884e-06	52.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_2882528_1	925409.KI911562_gene479	5.835e-09	61.0	COG0520@1|root,COG0520@2|Bacteria,4NF4G@976|Bacteroidetes,1IR6S@117747|Sphingobacteriia	976|Bacteroidetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_2924382_2	1316936.K678_10691	5.405e-10	62.0	2C7CG@1|root,33AMC@2|Bacteria,1NQDB@1224|Proteobacteria,2UKNG@28211|Alphaproteobacteria,2JY58@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2924382_0	1273538.G159_07035	8.657e-36	143.0	COG2318@1|root,COG2318@2|Bacteria,1VI69@1239|Firmicutes,4HPG9@91061|Bacilli,26HDR@186818|Planococcaceae	91061|Bacilli	S	DinB family	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
HKD1_k127_2924382_1	926550.CLDAP_37060	9.202e-30	124.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD1_k127_2924382_3	391937.NA2_17781	7.675e-09	68.0	COG0596@1|root,COG0596@2|Bacteria,1R5ID@1224|Proteobacteria,2U12K@28211|Alphaproteobacteria,43NQH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_2930498_8	234267.Acid_0622	2.169e-75	264.0	COG1004@1|root,COG1004@2|Bacteria,3Y3GR@57723|Acidobacteria	2|Bacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.132,1.1.1.22	ko:K00012,ko:K00066	ko00040,ko00051,ko00053,ko00520,ko01100,ko02020,map00040,map00051,map00053,map00520,map01100,map02020	M00014,M00129,M00361,M00362	R00286,R00880	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_2930498_14	497964.CfE428DRAFT_5272	2.477e-24	113.0	COG2813@1|root,COG2813@2|Bacteria	2|Bacteria	J	rRNA (guanine-N2-)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase,MMPL,Methyltransf_21,Methyltransf_25,Methyltransf_31
HKD1_k127_2930498_10	909663.KI867150_gene893	1.066e-63	228.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_2930498_18	338966.Ppro_1851	3.114e-09	61.0	2EGQI@1|root,33AGP@2|Bacteria,1NHU7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
HKD1_k127_2930498_15	1122132.AQYH01000007_gene2060	2.485e-24	109.0	COG3126@1|root,COG3187@1|root,COG3126@2|Bacteria,COG3187@2|Bacteria,1N78G@1224|Proteobacteria,2UHM9@28211|Alphaproteobacteria,4BDEK@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META,MliC
HKD1_k127_2930498_17	571166.KI421509_gene838	3.415e-11	66.0	2EGQI@1|root,33AGP@2|Bacteria,1NHU7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
HKD1_k127_2930498_2	909663.KI867149_gene3370	7.182e-162	530.0	COG1075@1|root,COG1075@2|Bacteria,1NYAK@1224|Proteobacteria,42Q3C@68525|delta/epsilon subdivisions,2WMAK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_2930498_13	349161.Dred_0467	1.204e-28	130.0	COG0265@1|root,COG0265@2|Bacteria,1UYZJ@1239|Firmicutes,24JSN@186801|Clostridia	186801|Clostridia	O	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_2930498_3	671143.DAMO_0005	2.287e-153	497.0	COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_2930498_4	671143.DAMO_0004	2.338e-126	418.0	COG0612@1|root,COG0612@2|Bacteria,2NPE5@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_2930498_6	264198.Reut_B4586	1.684e-93	323.0	COG3064@1|root,COG3064@2|Bacteria,1MXPS@1224|Proteobacteria,2VKTY@28216|Betaproteobacteria,1K11H@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_2930498_5	335543.Sfum_2322	4.79e-98	335.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD1_k127_2930498_7	1476583.DEIPH_ctg047orf0003	5.422e-87	298.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HKD1_k127_2930498_0	335543.Sfum_2959	1.136e-208	658.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2MQT1@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_2930498_9	748247.AZKH_2006	1.354e-69	249.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,2KW9W@206389|Rhodocyclales	206389|Rhodocyclales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_2930498_16	1537994.JQFW01000057_gene375	5.521e-14	82.0	COG0385@1|root,COG0385@2|Bacteria,1MXF3@1224|Proteobacteria,1RNZF@1236|Gammaproteobacteria,467CH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Na -dependent transporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD1_k127_2930498_1	1283300.ATXB01000001_gene385	3.416e-172	563.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XEIK@135618|Methylococcales	135618|Methylococcales	KT	PFAM RNA polymerase sigma factor 54, interaction	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
HKD1_k127_2932881_2	266117.Rxyl_2362	3.685e-10	64.0	COG2128@1|root,COG2128@2|Bacteria,2I829@201174|Actinobacteria,4CTTA@84995|Rubrobacteria	84995|Rubrobacteria	S	carboxymuconolactone decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_2932881_3	570952.ATVH01000005_gene1156	5.413e-06	55.0	COG4454@1|root,COG4454@2|Bacteria,1R91G@1224|Proteobacteria,2U6DH@28211|Alphaproteobacteria,2JSVB@204441|Rhodospirillales	204441|Rhodospirillales	P	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD1_k127_2932881_4	1200792.AKYF01000012_gene1182	0.0002896	45.0	COG1994@1|root,COG1994@2|Bacteria,1TRIF@1239|Firmicutes,4HE7E@91061|Bacilli	91061|Bacilli	S	Peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2932881_1	264198.Reut_A2916	1.997e-19	94.0	2DP14@1|root,3303I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2932881_0	1121861.KB899934_gene487	5.64e-122	396.0	COG1921@1|root,COG1921@2|Bacteria,1MW8F@1224|Proteobacteria,2TSR8@28211|Alphaproteobacteria,2JYRT@204441|Rhodospirillales	204441|Rhodospirillales	E	L-seryl-tRNA selenium transferase	-	-	-	-	-	-	-	-	-	-	-	-	SelA
HKD1_k127_294700_1	1159870.KB907784_gene2946	4.2e-50	192.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2VN6W@28216|Betaproteobacteria,3T882@506|Alcaligenaceae	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_294700_3	272624.lpg1633	1.105e-43	170.0	2D6MI@1|root,30AQT@2|Bacteria,1P8HC@1224|Proteobacteria,1T7XG@1236|Gammaproteobacteria,1JFZQ@118969|Legionellales	118969|Legionellales	S	PAP2 superfamily C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_C
HKD1_k127_294700_0	1267535.KB906767_gene4518	2.732e-144	463.0	COG1633@1|root,COG1633@2|Bacteria,3Y42J@57723|Acidobacteria,2JM0I@204432|Acidobacteriia	204432|Acidobacteriia	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_294700_2	1246995.AFR_42580	1.21e-44	171.0	COG1764@1|root,COG1764@2|Bacteria,2IFFB@201174|Actinobacteria,4DCYH@85008|Micromonosporales	201174|Actinobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD1_k127_294700_5	525904.Tter_2238	3.742e-08	61.0	COG2132@1|root,COG4454@1|root,COG2132@2|Bacteria,COG4454@2|Bacteria,2NPD2@2323|unclassified Bacteria	2|Bacteria	Q	Multicopper oxidase	-	GO:0005575,GO:0005623,GO:0042597,GO:0044464	1.16.3.3,1.7.2.1	ko:K00368,ko:K18683,ko:K22348	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1,DUF4396
HKD1_k127_294700_4	543728.Vapar_0693	1.615e-11	72.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,2VY9Z@28216|Betaproteobacteria,4AFU1@80864|Comamonadaceae	28216|Betaproteobacteria	K	PFAM zinc finger, DksA TraR C4-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD1_k127_3015181_3	443598.AUFA01000127_gene7209	9.111e-14	71.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria,3JYZA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_3015181_1	1037409.BJ6T_61420	1.905e-39	160.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_3015181_5	321327.CYA_2305	1.156e-08	60.0	COG1225@1|root,COG1225@2|Bacteria,1G6V9@1117|Cyanobacteria,1H0ZA@1129|Synechococcus	1117|Cyanobacteria	O	AhpC Tsa family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_3015181_0	1380394.JADL01000008_gene3608	1.461e-161	524.0	COG2223@1|root,COG2223@2|Bacteria,1MVFQ@1224|Proteobacteria,2U0IE@28211|Alphaproteobacteria,2JZQM@204441|Rhodospirillales	204441|Rhodospirillales	P	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_3015181_6	1504672.669783518	2.251e-05	52.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,4A9VK@80864|Comamonadaceae	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_3015181_4	1121920.AUAU01000007_gene543	6.705e-09	57.0	COG0604@1|root,COG0604@2|Bacteria,3Y4X4@57723|Acidobacteria	57723|Acidobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3015181_2	1192124.LIG30_1791	1.52e-17	82.0	COG0604@1|root,COG0604@2|Bacteria,1R8NX@1224|Proteobacteria,2W0KY@28216|Betaproteobacteria,1K4PK@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_3015639_33	1101192.KB910516_gene1733	1.835e-13	78.0	COG0775@1|root,COG0775@2|Bacteria,1PETT@1224|Proteobacteria,2TTTB@28211|Alphaproteobacteria,1JUPC@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	Phosphorylase superfamily	MA20_16045	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_3015639_16	671143.DAMO_2629	7.398e-102	338.0	COG0767@1|root,COG0767@2|Bacteria,2NPFZ@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_3015639_24	671143.DAMO_2630	1.44e-81	299.0	COG1127@1|root,COG1127@2|Bacteria,2NP3U@2323|unclassified Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_3015639_25	671143.DAMO_2631	7.543e-79	278.0	COG1463@1|root,COG1463@2|Bacteria,2NPXJ@2323|unclassified Bacteria	2|Bacteria	Q	MlaD protein	ttg2C	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_3015639_4	1173027.Mic7113_1452	6.234e-166	552.0	COG1449@1|root,COG1449@2|Bacteria,1G0BM@1117|Cyanobacteria,1H9KC@1150|Oscillatoriales	1117|Cyanobacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
HKD1_k127_3015639_27	289376.THEYE_A1869	1.361e-43	167.0	COG2928@1|root,COG2928@2|Bacteria,3J0R2@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD1_k127_3015639_8	671143.DAMO_2633	8.615e-143	470.0	COG1253@1|root,COG1253@2|Bacteria,2NP04@2323|unclassified Bacteria	2|Bacteria	S	Transporter associated domain	ytfL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03699,ko:K06189	-	-	-	-	ko00000,ko02000,ko02042	9.A.40.1.2	-	-	CBS,CorC_HlyC,DUF21,TerC
HKD1_k127_3015639_28	443143.GM18_0796	1.173e-38	169.0	COG2982@1|root,COG2982@2|Bacteria,1QA6E@1224|Proteobacteria,42URI@68525|delta/epsilon subdivisions,2WQ69@28221|Deltaproteobacteria,43U4E@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA,AsmA_2,DUF3971,DUF748
HKD1_k127_3015639_20	497964.CfE428DRAFT_6227	5.21e-93	314.0	COG0676@1|root,COG0676@2|Bacteria,46VKE@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Aldose 1-epimerase	-	-	5.1.3.15	ko:K01792	ko00010,ko01100,ko01110,ko01120,ko01130,map00010,map01100,map01110,map01120,map01130	-	R02739	RC00563	ko00000,ko00001,ko01000	-	-	-	Aldose_epim
HKD1_k127_3015639_11	536019.Mesop_4520	3.34e-125	411.0	COG0031@1|root,COG0031@2|Bacteria,1Q4JV@1224|Proteobacteria,2VG8H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3015639_14	933262.AXAM01000015_gene69	1.308e-107	353.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,42M21@68525|delta/epsilon subdivisions,2WK4G@28221|Deltaproteobacteria,2MKV8@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_3015639_32	937777.Deipe_2940	2.254e-15	85.0	COG1434@1|root,COG1434@2|Bacteria,1WMM5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_3015639_15	861299.J421_2666	2.543e-107	368.0	COG0508@1|root,COG0508@2|Bacteria,1ZSYJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_3015639_5	671143.DAMO_1597	1.297e-163	521.0	COG0022@1|root,COG0022@2|Bacteria,2NNQZ@2323|unclassified Bacteria	2|Bacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Biotin_lipoyl,Transket_pyr,Transketolase_C
HKD1_k127_3015639_12	671143.DAMO_1598	5.491e-124	408.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_3015639_13	1382356.JQMP01000003_gene1909	3.115e-112	374.0	COG0489@1|root,COG0489@2|Bacteria,2G60P@200795|Chloroflexi,27XJW@189775|Thermomicrobia	189775|Thermomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD1_k127_3015639_31	192952.MM_0224	1.411e-20	96.0	COG3585@1|root,arCOG00228@2157|Archaea,2Y699@28890|Euryarchaeota,2NBCT@224756|Methanomicrobia	224756|Methanomicrobia	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	TOBE
HKD1_k127_3015639_26	365046.Rta_15490	2.604e-76	267.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,2VI8S@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate	-	-	4.1.1.3,5.4.2.9	ko:K01003,ko:K01841	ko00440,ko00620,ko01100,ko01120,ko01130,map00440,map00620,map01100,map01120,map01130	-	R00217,R00661	RC00040,RC02792	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD1_k127_3015639_3	1131730.BAVI_08331	1.395e-208	664.0	COG2079@1|root,COG2079@2|Bacteria,1TRR8@1239|Firmicutes,4HAUS@91061|Bacilli,1ZCS6@1386|Bacillus	91061|Bacilli	S	2-methylcitrate dehydratase	prpD	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0047547,GO:0071704	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD1_k127_3015639_6	1034943.BN1094_03603	7.216e-147	482.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNT1@1236|Gammaproteobacteria,1JCTF@118969|Legionellales	118969|Legionellales	C	Citrate synthase, C-terminal domain	prpC	-	2.3.3.5	ko:K01659	ko00640,map00640	-	R00931	RC00004,RC00406,RC02827	ko00000,ko00001,ko01000	-	-	-	Citrate_synt
HKD1_k127_3015639_34	1179778.PMM47T1_19743	0.0004192	48.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,1RPSX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	paaF	GO:0003674,GO:0003824,GO:0004300,GO:0005488,GO:0005515,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0006725,GO:0006805,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009404,GO:0009407,GO:0009410,GO:0009636,GO:0009850,GO:0009852,GO:0009987,GO:0010124,GO:0010817,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019439,GO:0019748,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0042178,GO:0042221,GO:0042445,GO:0042447,GO:0042537,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070887,GO:0071466,GO:0071704,GO:0072329,GO:0098754,GO:1901360,GO:1901361,GO:1901575	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_3015639_1	306281.AJLK01000134_gene1553	2.375e-320	1000.0	COG1960@1|root,COG1960@2|Bacteria,1G3AS@1117|Cyanobacteria	1117|Cyanobacteria	I	PFAM Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K06445	ko00071,ko01100,ko01212,map00071,map01100,map01212	M00087	R01175,R01279,R03777,R03857,R03990,R04751,R04754	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N,DUF1974
HKD1_k127_3015639_0	1120971.AUCA01000004_gene1313	0.0	1351.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli,27812@186823|Alicyclobacillaceae	91061|Bacilli	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD1_k127_3015639_30	644282.Deba_1535	4.851e-26	113.0	COG1545@1|root,COG1545@2|Bacteria	2|Bacteria	I	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD1_k127_3015639_7	644282.Deba_1534	1.31e-143	469.0	COG0183@1|root,COG0183@2|Bacteria,1MU8C@1224|Proteobacteria,42N6X@68525|delta/epsilon subdivisions,2WJIE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_3015639_22	716544.wcw_1472	5.069e-89	316.0	COG1250@1|root,COG1250@2|Bacteria,2JFTQ@204428|Chlamydiae	204428|Chlamydiae	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N
HKD1_k127_3015639_9	264462.Bd2095	6.923e-135	445.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,42MSR@68525|delta/epsilon subdivisions,2MSP4@213481|Bdellovibrionales,2WIXG@28221|Deltaproteobacteria	213481|Bdellovibrionales	I	Belongs to the thiolase family	bamN	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_3015639_29	1265505.ATUG01000002_gene981	1.212e-26	118.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria,1MVQY@1224|Proteobacteria,42REC@68525|delta/epsilon subdivisions,2WNN1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD1_k127_3015639_23	1295642.H839_16813	2.511e-84	295.0	COG0508@1|root,COG0508@2|Bacteria,1TR5N@1239|Firmicutes,4HFK2@91061|Bacilli,1WE49@129337|Geobacillus	91061|Bacilli	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_3015639_10	404589.Anae109_1994	1.563e-128	420.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42N06@68525|delta/epsilon subdivisions,2WK5N@28221|Deltaproteobacteria,2YTX4@29|Myxococcales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	bkdB	-	1.2.4.1,1.2.4.4	ko:K00162,ko:K00167	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_3015639_21	448385.sce1571	1.216e-92	317.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42NW8@68525|delta/epsilon subdivisions,2WJY1@28221|Deltaproteobacteria,2YV62@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase E1 component	bkdA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00166	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_3015639_2	469371.Tbis_0788	2.25e-240	760.0	COG0365@1|root,COG0365@2|Bacteria,2GM20@201174|Actinobacteria,4DXBK@85010|Pseudonocardiales	201174|Actinobacteria	I	TIGRFAM Acetoacetyl-CoA synthase	acsA1	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_3015639_17	671143.DAMO_1145	1.118e-101	353.0	COG3842@1|root,COG3842@2|Bacteria,2NNPE@2323|unclassified Bacteria	2|Bacteria	E	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	gtsA	-	3.6.3.25,3.6.3.30,3.6.3.31,3.6.3.55	ko:K02010,ko:K02045,ko:K02049,ko:K02068,ko:K02071,ko:K06857,ko:K10112,ko:K11072	ko00920,ko02010,map00920,map02010	M00185,M00186,M00188,M00190,M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00211,M00238,M00299,M00491,M00602,M00605,M00606	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.10,3.A.1.11.1,3.A.1.16,3.A.1.17,3.A.1.24,3.A.1.6.1,3.A.1.6.2,3.A.1.6.3,3.A.1.6.4	-	-	ABC_tran,TOBE_2
HKD1_k127_3015639_18	671143.DAMO_1144	1.371e-101	335.0	COG4662@1|root,COG4662@2|Bacteria,2NPF5@2323|unclassified Bacteria	2|Bacteria	H	Binding-protein-dependent transport system inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD1_k127_3015639_19	671143.DAMO_1132	9.238e-97	320.0	COG2998@1|root,COG2998@2|Bacteria,2NP4U@2323|unclassified Bacteria	2|Bacteria	H	PBP superfamily domain	tupB	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_3016341_0	204669.Acid345_3939	2.277e-154	496.0	COG0531@1|root,COG0531@2|Bacteria,3Y356@57723|Acidobacteria,2JP5J@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3016341_5	1385514.N782_15215	1.987e-62	226.0	COG1082@1|root,COG1082@2|Bacteria,1UITG@1239|Firmicutes,4HFIC@91061|Bacilli	91061|Bacilli	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_3016341_1	1380394.JADL01000010_gene4184	3.352e-100	344.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,2JPWP@204441|Rhodospirillales	204441|Rhodospirillales	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_3016341_3	1125973.JNLC01000002_gene1995	1.392e-83	291.0	28PPE@1|root,2ZCBU@2|Bacteria,1RC73@1224|Proteobacteria,2U68E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD1_k127_3016341_2	1380394.JADL01000010_gene4183	2.631e-87	295.0	COG0600@1|root,COG0600@2|Bacteria,1PH8M@1224|Proteobacteria,2V8ZI@28211|Alphaproteobacteria,2JXIM@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_3016341_4	1125973.JNLC01000002_gene1997	2.981e-66	235.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2U275@28211|Alphaproteobacteria,3JRFE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_3016341_6	1121087.AUCK01000002_gene2439	7.49e-40	158.0	COG2188@1|root,COG2188@2|Bacteria,1UYBW@1239|Firmicutes,4HDDG@91061|Bacilli,1ZBS6@1386|Bacillus	91061|Bacilli	K	transcriptional	yvoA	-	-	ko:K03710	-	-	-	-	ko00000,ko03000	-	-	-	GntR,UTRA
HKD1_k127_3016341_7	671143.DAMO_1642	5.248e-27	114.0	COG1560@1|root,COG1560@2|Bacteria,2NPD7@2323|unclassified Bacteria	2|Bacteria	M	Lipid A biosynthesis	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD1_k127_3016341_9	1125863.JAFN01000001_gene1373	4.628e-11	72.0	2DD8H@1|root,2ZH1Z@2|Bacteria,1PBE0@1224|Proteobacteria,432B3@68525|delta/epsilon subdivisions,2WY4T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3016341_8	596151.DesfrDRAFT_1726	4.311e-19	96.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42V9Q@68525|delta/epsilon subdivisions,2WRRT@28221|Deltaproteobacteria,2MCID@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3016341_10	338963.Pcar_2643	3.713e-05	54.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_3016341_11	272134.KB731324_gene4454	0.0003764	51.0	COG3668@1|root,COG3668@2|Bacteria,1G7Z2@1117|Cyanobacteria,1HCAD@1150|Oscillatoriales	1117|Cyanobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD1_k127_3016557_1	269799.Gmet_0234	2.657e-51	187.0	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria	1224|Proteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
HKD1_k127_3016557_8	1282362.AEAC466_17505	0.0008996	43.0	COG5126@1|root,COG5126@2|Bacteria,1NAM6@1224|Proteobacteria,2UH6E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	DTZ	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5,EF-hand_7
HKD1_k127_3016557_5	1274524.BSONL12_18349	4.868e-19	95.0	COG3467@1|root,COG3467@2|Bacteria,1V2CN@1239|Firmicutes,4HBSQ@91061|Bacilli,1ZGCZ@1386|Bacillus	91061|Bacilli	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD1_k127_3016557_2	1449126.JQKL01000004_gene556	8.935e-40	154.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,24KDQ@186801|Clostridia	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3016557_0	1499967.BAYZ01000159_gene530	4.466e-66	239.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3016557_7	693661.Arcve_1072	1.211e-05	54.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,246E5@183980|Archaeoglobi	183980|Archaeoglobi	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_3016557_3	671143.DAMO_2125	1.893e-39	150.0	COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria	2|Bacteria	S	RNA recognition motif	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3016557_4	671143.DAMO_2124	1.603e-20	93.0	COG0828@1|root,COG0828@2|Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_3024580_2	338963.Pcar_2643	9.097e-110	364.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_3024580_7	252305.OB2597_04610	7.142e-22	101.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2U79E@28211|Alphaproteobacteria,2PE7C@252301|Oceanicola	28211|Alphaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	slyD	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HKD1_k127_3024580_10	1123301.KB904188_gene1177	3.664e-05	51.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,4HKJ1@91061|Bacilli	91061|Bacilli	L	COG1555 DNA uptake protein and related DNA-binding proteins	comEA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HKD1_k127_3024580_0	370438.PTH_1586	2.166e-199	642.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,261BK@186807|Peptococcaceae	186801|Clostridia	G	Domain of unknown function (DUF3459)	-	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48,DUF3459
HKD1_k127_3024580_4	671143.DAMO_1116	1.948e-70	254.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD1_k127_3024580_9	1122237.AUGQ01000001_gene1090	5.003e-07	58.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4FQ5V@85023|Microbacteriaceae	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD1_k127_3024580_6	1499967.BAYZ01000068_gene1948	8.001e-25	111.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3024580_1	1242864.D187_005468	4.75e-131	432.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJKZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Response regulator receiver	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3024580_3	671143.DAMO_1544	6.764e-79	284.0	COG4191@1|root,COG4191@2|Bacteria,2NPGF@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_3024580_5	273526.SMDB11_2881	2.672e-61	221.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,1SYHW@1236|Gammaproteobacteria,4033P@613|Serratia	1236|Gammaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_3024580_8	760568.Desku_0245	9.608e-12	75.0	COG0655@1|root,COG0655@2|Bacteria,1V2PA@1239|Firmicutes,24GUN@186801|Clostridia	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_3024580_11	436229.JOEH01000037_gene2669	7.828e-05	46.0	COG0604@1|root,COG0604@2|Bacteria,2GKHW@201174|Actinobacteria,2NGD8@228398|Streptacidiphilus	201174|Actinobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD1_k127_3027780_11	1235799.C818_00850	2.308e-17	87.0	COG0673@1|root,COG0673@2|Bacteria,1V8V8@1239|Firmicutes,24PDR@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_3027780_4	1499967.BAYZ01000104_gene3694	1.661e-105	348.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000104_gene3694|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3027780_6	492774.JQMB01000003_gene2518	1.758e-102	343.0	COG3718@1|root,COG3718@2|Bacteria,1MWGD@1224|Proteobacteria,2TUJZ@28211|Alphaproteobacteria,4BBVH@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	KduI/IolB family	iolB2	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD1_k127_3027780_1	1499967.BAYZ01000195_gene3110	1.618e-186	599.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_3027780_10	1499967.BAYZ01000195_gene3109	8.367e-49	183.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_3027780_2	1499967.BAYZ01000195_gene3108	5.269e-158	507.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_3027780_5	595537.Varpa_3958	8.566e-103	346.0	COG0600@1|root,COG0600@2|Bacteria,1MVAE@1224|Proteobacteria,2VMJ5@28216|Betaproteobacteria,4AH5X@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_3027780_3	93220.LV28_08055	5.102e-120	395.0	COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,2VJ9W@28216|Betaproteobacteria,1KH1U@119060|Burkholderiaceae	28216|Betaproteobacteria	M	NMT1/THI5 like	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_3027780_7	543728.Vapar_1860	1.966e-102	346.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2WEDA@28216|Betaproteobacteria,4ADUF@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_3027780_0	886293.Sinac_5129	2.537e-205	651.0	COG4948@1|root,COG4948@2|Bacteria,2IXK2@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C
HKD1_k127_3027780_9	1499967.BAYZ01000057_gene4726	6.562e-63	227.0	COG1082@1|root,COG1082@2|Bacteria,2NRTI@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_3027780_8	530564.Psta_3167	9.377e-78	264.0	COG0673@1|root,COG0673@2|Bacteria,2IYB5@203682|Planctomycetes	203682|Planctomycetes	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_3036967_1	317936.Nos7107_2784	1.614e-26	114.0	28MKU@1|root,2ZAWW@2|Bacteria,1G4PA@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3036967_0	1123508.JH636460_gene192	8.973e-63	226.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IZX0@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_3037373_31	1108045.GORHZ_183_00320	5.79e-07	59.0	COG1541@1|root,COG1541@2|Bacteria,2HQVK@201174|Actinobacteria,4GGFN@85026|Gordoniaceae	201174|Actinobacteria	H	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding_C_2
HKD1_k127_3037373_20	580332.Slit_1368	2.213e-52	209.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,2VMHK@28216|Betaproteobacteria,44V80@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_3037373_26	443144.GM21_2023	1.592e-27	129.0	COG0671@1|root,COG0671@2|Bacteria,1RIRR@1224|Proteobacteria,42X79@68525|delta/epsilon subdivisions,2WSVG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD1_k127_3037373_21	247490.KSU1_D0759	3.476e-50	199.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	wzi	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi,PAP2
HKD1_k127_3037373_25	247490.KSU1_D0759	1.032e-30	130.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	wzi	-	-	-	-	-	-	-	-	-	-	-	Caps_assemb_Wzi,PAP2
HKD1_k127_3037373_5	247490.KSU1_D0757	1.885e-150	509.0	COG1596@1|root,COG1596@2|Bacteria	2|Bacteria	M	polysaccharide export	kpsD	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Caps_synth_GfcC,Poly_export,SLBB
HKD1_k127_3037373_4	671143.DAMO_1404	3.579e-162	520.0	COG0082@1|root,COG0082@2|Bacteria,2NNQ8@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016491,GO:0016651,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0976,iNJ661.Rv2540c	Chorismate_synt
HKD1_k127_3037373_10	671143.DAMO_1408	4.929e-122	422.0	COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria	2|Bacteria	U	Secretin and TonB N terminus short domain	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
HKD1_k127_3037373_24	671143.DAMO_1410	1.828e-31	132.0	COG3167@1|root,COG3167@2|Bacteria,2NPUF@2323|unclassified Bacteria	2|Bacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD1_k127_3037373_28	671143.DAMO_1411	1.563e-22	104.0	COG3166@1|root,COG3166@2|Bacteria	2|Bacteria	NU	PFAM Fimbrial assembly family protein	pilN	-	-	ko:K02662,ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD1_k127_3037373_9	671143.DAMO_1412	2.112e-122	402.0	COG4972@1|root,COG4972@2|Bacteria,2NPF6@2323|unclassified Bacteria	2|Bacteria	NU	Type IV pilus assembly protein PilM;	pilM	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD1_k127_3037373_32	1265505.ATUG01000003_gene189	5.733e-06	56.0	COG4966@1|root,COG4966@2|Bacteria,1N2NR@1224|Proteobacteria,42TRJ@68525|delta/epsilon subdivisions,2WQQ2@28221|Deltaproteobacteria,2MKHU@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	pilus assembly protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,PilW
HKD1_k127_3037373_33	1125863.JAFN01000001_gene730	0.0005764	50.0	COG4967@1|root,COG4967@2|Bacteria	2|Bacteria	NU	type IV pilus modification protein PilV	-	-	-	ko:K02459,ko:K02671	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15	-	-	N_methyl
HKD1_k127_3037373_29	56780.SYN_01761	4.941e-11	71.0	COG4970@1|root,COG4970@2|Bacteria	2|Bacteria	NU	protein transport across the cell outer membrane	-	-	-	ko:K02246,ko:K08084	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.15.2	-	-	GspH,N_methyl
HKD1_k127_3037373_14	671143.DAMO_1413	4.105e-77	267.0	COG0159@1|root,COG0159@2|Bacteria,2NP9W@2323|unclassified Bacteria	2|Bacteria	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD1_k127_3037373_1	671143.DAMO_1414	1.286e-188	596.0	COG0133@1|root,COG0133@2|Bacteria,2NNWF@2323|unclassified Bacteria	2|Bacteria	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3037373_18	338966.Ppro_1292	1.039e-57	210.0	COG0135@1|root,COG0135@2|Bacteria,1RA87@1224|Proteobacteria,42QQ3@68525|delta/epsilon subdivisions,2WNPH@28221|Deltaproteobacteria,43U0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the TrpF family	trpF	-	5.3.1.24	ko:K01817	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03509	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD1_k127_3037373_15	671143.DAMO_1416	7.169e-72	252.0	COG0134@1|root,COG0134@2|Bacteria,2NPIH@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the TrpC family	trpC	GO:0003674,GO:0003824,GO:0004425,GO:0016829,GO:0016830,GO:0016831	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD1_k127_3037373_6	671143.DAMO_1417	2.361e-132	434.0	COG0547@1|root,COG0547@2|Bacteria,2NNVH@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	GO:0000162,GO:0003674,GO:0003824,GO:0004048,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2495	GATase,Glycos_trans_3N,Glycos_transf_3
HKD1_k127_3037373_13	497964.CfE428DRAFT_0598	6.224e-85	285.0	COG0512@1|root,COG0512@2|Bacteria,46SN1@74201|Verrucomicrobia	74201|Verrucomicrobia	EH	PFAM glutamine amidotransferase class-I	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_3037373_3	398767.Glov_2547	2.243e-175	562.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,42MXN@68525|delta/epsilon subdivisions,2WJN0@28221|Deltaproteobacteria,43TZF@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657,ko:K13503	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_3037373_22	671143.DAMO_1420	7.679e-36	151.0	COG3118@1|root,COG3118@2|Bacteria,2NPNZ@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the thioredoxin family	trxC	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_3037373_27	1430440.MGMSRv2_1085	1.61e-27	121.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,2JSAS@204441|Rhodospirillales	204441|Rhodospirillales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD1_k127_3037373_0	671143.DAMO_1424	1.362e-243	795.0	COG1196@1|root,COG1196@2|Bacteria,2NNYZ@2323|unclassified Bacteria	2|Bacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_3037373_11	1121430.JMLG01000006_gene1788	2.697e-98	329.0	COG0552@1|root,COG0552@2|Bacteria,1TPRI@1239|Firmicutes,247JD@186801|Clostridia,260N3@186807|Peptococcaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_3037373_7	1121468.AUBR01000026_gene2918	1.894e-126	414.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD1_k127_3037373_19	1121472.AQWN01000002_gene2312	1.04e-56	205.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,260I1@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD1_k127_3037373_2	671143.DAMO_1428	9.575e-180	580.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,2NNKV@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K01497,ko:K02858,ko:K14652	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830,iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_3037373_16	443143.GM18_3008	1.986e-67	232.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,43UNX@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_3037373_23	667014.Thein_1879	2.527e-33	133.0	COG0781@1|root,COG0781@2|Bacteria,2GHUU@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD1_k127_3037373_30	926550.CLDAP_34720	3.12e-07	59.0	COG0260@1|root,COG0260@2|Bacteria,2G617@200795|Chloroflexi	200795|Chloroflexi	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD1_k127_3037373_17	903818.KI912269_gene400	2.247e-58	205.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD1_k127_3037373_8	645991.Sgly_3090	6.198e-126	410.0	COG2084@1|root,COG2084@2|Bacteria,1TR4F@1239|Firmicutes,249YG@186801|Clostridia,262SR@186807|Peptococcaceae	186801|Clostridia	I	PFAM NAD binding domain of 6-phosphogluconate dehydrogenase	-	-	1.1.1.60	ko:K00042	ko00630,ko01100,map00630,map01100	-	R01745,R01747	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_3037373_12	596152.DesU5LDRAFT_3486	4.93e-92	308.0	COG3622@1|root,COG3622@2|Bacteria,1MV53@1224|Proteobacteria,42Y15@68525|delta/epsilon subdivisions,2WT2S@28221|Deltaproteobacteria,2MACA@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Belongs to the hyi family	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_3042349_0	381666.H16_B1352	1.066e-115	394.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2VMY9@28216|Betaproteobacteria,1K6F2@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Insecticidal toxin complex protein TcaC	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
HKD1_k127_3042349_1	1273538.G159_19950	2.267e-92	321.0	COG2351@1|root,COG3409@1|root,COG2351@2|Bacteria,COG3409@2|Bacteria,1V08W@1239|Firmicutes	1239|Firmicutes	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	VRP1
HKD1_k127_3048589_7	316058.RPB_0146	1.662e-103	341.0	COG0251@1|root,COG0251@2|Bacteria,1N1B6@1224|Proteobacteria,2TZWE@28211|Alphaproteobacteria,3JRZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3048589_13	456442.Mboo_0014	1.368e-61	218.0	COG1853@1|root,arCOG02016@2157|Archaea,2XYAJ@28890|Euryarchaeota,2N9RF@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_3048589_6	768704.Desmer_1384	4.102e-106	354.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,261Z4@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_3048589_24	1499967.BAYZ01000102_gene3556	2.587e-24	106.0	COG0826@1|root,COG0826@2|Bacteria,2NPQH@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	ydcP	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD1_k127_3048589_1	498761.HM1_1305	3.207e-159	517.0	COG1640@1|root,COG1640@2|Bacteria,1W5VQ@1239|Firmicutes,25E46@186801|Clostridia	186801|Clostridia	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD1_k127_3048589_11	1267535.KB906767_gene266	1.872e-73	256.0	COG1878@1|root,COG1878@2|Bacteria,3Y72H@57723|Acidobacteria	57723|Acidobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD1_k127_3048589_19	243365.CV_4378	3.359e-37	149.0	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,2VSGQ@28216|Betaproteobacteria,2KRD6@206351|Neisseriales	206351|Neisseriales	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3048589_25	880072.Desac_0156	4.272e-10	63.0	COG2331@1|root,COG2331@2|Bacteria,1NMRY@1224|Proteobacteria	1224|Proteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_3048589_26	882.DVU_3388	1.992e-05	49.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,43BM7@68525|delta/epsilon subdivisions,2X6ZD@28221|Deltaproteobacteria,2MH97@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD1_k127_3048589_22	1210884.HG799462_gene8487	5.625e-32	133.0	COG0517@1|root,COG0517@2|Bacteria,2J0FD@203682|Planctomycetes	203682|Planctomycetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_3048589_2	479434.Sthe_2520	1.799e-142	470.0	COG0154@1|root,COG0154@2|Bacteria,2G5T0@200795|Chloroflexi,27Y0A@189775|Thermomicrobia	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	GO:0008150,GO:0040007	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_3048589_23	448385.sce1473	8.18e-29	122.0	COG1193@1|root,COG1193@2|Bacteria,1NCS6@1224|Proteobacteria,42VGJ@68525|delta/epsilon subdivisions,2WRA6@28221|Deltaproteobacteria,2YVNG@29|Myxococcales	28221|Deltaproteobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD1_k127_3048589_17	880072.Desac_0961	8.965e-50	190.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,42T3V@68525|delta/epsilon subdivisions,2X2EJ@28221|Deltaproteobacteria,2MSD1@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
HKD1_k127_3048589_15	671143.DAMO_2862	4.09e-53	193.0	COG0242@1|root,COG0242@2|Bacteria	2|Bacteria	J	peptide deformylase activity	def2	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD1_k127_3048589_5	1353529.M899_0311	8.583e-120	391.0	COG1951@1|root,COG1951@2|Bacteria,1MUV9@1224|Proteobacteria,42MC7@68525|delta/epsilon subdivisions,2WKIV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD1_k127_3048589_12	1078085.HMPREF1210_02761	1.859e-71	246.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,4HA3C@91061|Bacilli,26DUU@186818|Planococcaceae	91061|Bacilli	C	Catalyzes the reversible hydration of fumarate to (S)- malate	fumA	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HKD1_k127_3048589_21	1449063.JMLS01000002_gene1247	3.305e-34	139.0	COG0457@1|root,COG0457@2|Bacteria,1V3MA@1239|Firmicutes,4HH74@91061|Bacilli,26SMD@186822|Paenibacillaceae	91061|Bacilli	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_3048589_10	586413.CCDL010000003_gene3256	2.172e-84	290.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HDBB@91061|Bacilli,23K50@182709|Oceanobacillus	91061|Bacilli	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_3048589_8	1444309.JAQG01000004_gene3668	5.286e-90	307.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,26RTC@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_3048589_4	1444309.JAQG01000004_gene3669	6.569e-125	422.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_3048589_3	1382304.JNIL01000001_gene1701	2.597e-135	446.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli	91061|Bacilli	E	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3048589_20	472759.Nhal_3411	3.612e-37	149.0	COG4221@1|root,COG4221@2|Bacteria,1QXBX@1224|Proteobacteria,1T4IE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
HKD1_k127_3048589_14	1286093.C266_02081	6.365e-56	198.0	COG2128@1|root,COG2128@2|Bacteria,1RD2I@1224|Proteobacteria,2VV72@28216|Betaproteobacteria,1K788@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_3048589_0	880072.Desac_2817	8.467e-173	574.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
HKD1_k127_3048589_18	335543.Sfum_3476	1.298e-45	179.0	COG0484@1|root,COG0484@2|Bacteria,1R9Y3@1224|Proteobacteria,42RBH@68525|delta/epsilon subdivisions,2WP1M@28221|Deltaproteobacteria,2MRJD@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_3048589_16	1454004.AW11_02872	3.628e-50	183.0	COG1142@1|root,COG1142@2|Bacteria,1MWE1@1224|Proteobacteria,2VJ9U@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	ko:K05796	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_11,Fer4_4,Fer4_6,Fer4_9
HKD1_k127_3048589_9	1286631.X805_22550	2.455e-86	307.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2VKIS@28216|Betaproteobacteria,1KIVX@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3734,Patatin,Pyr_redox_2,Reductase_C
HKD1_k127_3053974_2	1207063.P24_01340	2.421e-31	124.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TQJF@28211|Alphaproteobacteria,2JRNV@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10229	ko02010,map02010	M00200	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.5	-	-	BPD_transp_1
HKD1_k127_3053974_1	639283.Snov_1914	8.758e-118	385.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,3EZN9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_3053974_0	639283.Snov_1915	1.774e-142	465.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_3053974_3	679200.HMPREF9333_00096	5.297e-07	56.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia	186801|Clostridia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3055558_1	1211115.ALIQ01000174_gene3541	1.901e-175	565.0	COG0191@1|root,COG0191@2|Bacteria,1NUAP@1224|Proteobacteria	1224|Proteobacteria	G	Fructose-bisphosphate aldolase class-II	-	-	-	-	-	-	-	-	-	-	-	-	F_bP_aldolase
HKD1_k127_3055558_0	1211115.ALIQ01000174_gene3540	5.769e-177	563.0	COG1653@1|root,COG1653@2|Bacteria,1R767@1224|Proteobacteria,2U1C0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_3058656_1	204669.Acid345_0001	1.086e-30	123.0	COG0593@1|root,COG0593@2|Bacteria,3Y2HA@57723|Acidobacteria,2JHN7@204432|Acidobacteriia	204432|Acidobacteriia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_3058656_0	1267535.KB906767_gene3182	2.97e-88	304.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria,2JI4X@204432|Acidobacteriia	204432|Acidobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD1_k127_3068816_2	1464048.JNZS01000003_gene1081	6.301e-14	81.0	COG0611@1|root,COG0611@2|Bacteria,2I8EE@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	-	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_3068816_0	714943.Mucpa_6874	3.044e-129	428.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes,1INN3@117747|Sphingobacteriia	976|Bacteroidetes	E	PFAM Aminotransferase class I and II	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3068816_1	448385.sce5522	1.04e-50	190.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42MCH@68525|delta/epsilon subdivisions,2WJPZ@28221|Deltaproteobacteria,2Z39Q@29|Myxococcales	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_3077747_0	926569.ANT_05210	2.309e-81	279.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_3077747_2	886293.Sinac_2019	4.311e-58	205.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_3077747_3	268407.PWYN_18665	1.147e-26	113.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,26Q92@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_3077747_1	1267533.KB906745_gene60	6.179e-63	217.0	COG0166@1|root,COG0166@2|Bacteria,3Y3HG@57723|Acidobacteria,2JIQE@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the GPI family	-	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_3079204_1	1038869.AXAN01000036_gene2113	1.006e-14	76.0	28M5B@1|root,2ZAJ4@2|Bacteria,1R7Y9@1224|Proteobacteria,2VSMK@28216|Betaproteobacteria,1K5H6@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3079204_0	1123242.JH636434_gene5275	1.7e-153	502.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD1_k127_3084860_7	1120985.AUMI01000016_gene1909	1.629e-55	205.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,4H2HX@909932|Negativicutes	909932|Negativicutes	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HKD1_k127_3084860_4	1158345.JNLL01000001_gene901	1.283e-105	350.0	COG0253@1|root,COG0253@2|Bacteria,2G4B5@200783|Aquificae	200783|Aquificae	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD1_k127_3084860_2	572547.Amico_1317	8.885e-131	424.0	COG2513@1|root,COG2513@2|Bacteria,3T9VU@508458|Synergistetes	508458|Synergistetes	G	Phosphoenolpyruvate phosphomutase	-	-	4.1.3.32	ko:K20454	ko00760,ko01120,map00760,map01120	-	R01355	RC00286,RC01810	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD1_k127_3084860_0	469381.Dpep_1619	2.28e-193	613.0	COG1593@1|root,COG1593@2|Bacteria,3T9YH@508458|Synergistetes	508458|Synergistetes	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
HKD1_k127_3084860_8	580340.Tlie_0220	3.24e-45	170.0	COG4665@1|root,COG4665@2|Bacteria,3TCKH@508458|Synergistetes	508458|Synergistetes	Q	PFAM Tripartite ATP-independent periplasmic transporter DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_3084860_3	580340.Tlie_0219	4.553e-128	419.0	COG1638@1|root,COG1638@2|Bacteria,3TAI5@508458|Synergistetes	508458|Synergistetes	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_3084860_1	1415780.JPOG01000001_gene590	1.061e-181	578.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,1RNB5@1236|Gammaproteobacteria,1X5SD@135614|Xanthomonadales	135614|Xanthomonadales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_3084860_9	1265505.ATUG01000003_gene122	3.734e-23	105.0	COG0484@1|root,COG3339@1|root,COG0484@2|Bacteria,COG3339@2|Bacteria,1RIIG@1224|Proteobacteria,42SK6@68525|delta/epsilon subdivisions,2WPXU@28221|Deltaproteobacteria,2MK9Y@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232,DnaJ
HKD1_k127_3084860_5	1232410.KI421412_gene406	4.757e-87	303.0	COG1193@1|root,COG1193@2|Bacteria,1QYV7@1224|Proteobacteria	1224|Proteobacteria	L	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3084860_10	497964.CfE428DRAFT_6665	8.431e-21	97.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_3,HAMP,HATPase_c,HisKA,PAS_4,PAS_7,PAS_9,Response_reg
HKD1_k127_3084860_6	1120985.AUMI01000018_gene2985	1.728e-61	220.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4H20F@909932|Negativicutes	909932|Negativicutes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_3122671_2	867845.KI911784_gene3527	1.388e-149	478.0	COG4799@1|root,COG4799@2|Bacteria,2G5IX@200795|Chloroflexi,376MS@32061|Chloroflexia	32061|Chloroflexia	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD1_k127_3122671_8	867845.KI911784_gene3528	2.363e-22	101.0	COG3630@1|root,COG3630@2|Bacteria	2|Bacteria	C	sodium ion export across plasma membrane	oadG	GO:0003674,GO:0003824,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0008150,GO:0008948,GO:0015672,GO:0016829,GO:0016830,GO:0016831,GO:0030001,GO:0051179,GO:0051234	4.1.1.3	ko:K01573	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_gamma
HKD1_k127_3122671_7	684949.ATTJ01000001_gene2187	3.253e-28	120.0	COG4770@1|root,COG4770@2|Bacteria	2|Bacteria	I	CoA carboxylase activity	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD1_k127_3122671_1	684949.ATTJ01000001_gene2186	1.051e-168	538.0	COG1883@1|root,COG1883@2|Bacteria	2|Bacteria	C	oxaloacetate decarboxylase activity	oadB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD1_k127_3122671_4	909663.KI867150_gene245	3.167e-81	277.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,42PQF@68525|delta/epsilon subdivisions,2WMCA@28221|Deltaproteobacteria,2MQNC@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD1_k127_3122671_5	243231.GSU1736	1.275e-60	212.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,43SGJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD1_k127_3122671_3	1125863.JAFN01000001_gene1150	5.772e-90	327.0	COG2271@1|root,COG2271@2|Bacteria,1QX38@1224|Proteobacteria,42NSX@68525|delta/epsilon subdivisions,2WK8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_4,Sugar_tr
HKD1_k127_3122671_0	118005.AWNK01000007_gene599	2.943e-205	646.0	COG1541@1|root,COG1541@2|Bacteria	2|Bacteria	H	phenylacetate-CoA ligase activity	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1825	AMP-binding,AMP-binding_C_2
HKD1_k127_3122671_6	370438.PTH_2845	4.861e-52	190.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,261U9@186807|Peptococcaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_3126408_0	404380.Gbem_1240	0.0007604	49.0	COG2885@1|root,COG3637@1|root,COG2885@2|Bacteria,COG3637@2|Bacteria,1R8DG@1224|Proteobacteria,42NGC@68525|delta/epsilon subdivisions,2WVVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA
HKD1_k127_3141041_3	204669.Acid345_2512	2.986e-39	147.0	COG0667@1|root,COG0667@2|Bacteria,3Y2GF@57723|Acidobacteria,2JI5T@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_3141041_2	1298880.AUEV01000023_gene5233	1.642e-40	152.0	COG4334@1|root,COG4334@2|Bacteria,2IR4U@201174|Actinobacteria	201174|Actinobacteria	S	Uncharacterized protein conserved in bacteria (DUF2255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2255
HKD1_k127_3141041_5	338963.Pcar_1084	1.529e-32	133.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_3141041_1	338963.Pcar_1084	3.529e-69	244.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_3141041_0	290397.Adeh_3220	1.422e-71	245.0	COG0657@1|root,COG0657@2|Bacteria,1R41U@1224|Proteobacteria,42YKQ@68525|delta/epsilon subdivisions,2WU3G@28221|Deltaproteobacteria,2YY16@29|Myxococcales	28221|Deltaproteobacteria	I	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD1_k127_3141041_7	933262.AXAM01000070_gene2294	0.0005876	47.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_3141041_6	686340.Metal_2809	8.103e-20	91.0	2DS0K@1|root,33DZ7@2|Bacteria,1NKVW@1224|Proteobacteria,1SGDA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_3141041_4	713587.THITH_04565	3.399e-39	149.0	COG1598@1|root,COG1598@2|Bacteria,1N00D@1224|Proteobacteria,1TK9Z@1236|Gammaproteobacteria,1X0XS@135613|Chromatiales	135613|Chromatiales	S	HicB family	-	-	-	ko:K18843	-	-	-	-	ko00000,ko02048	-	-	-	HicB,HicB_lk_antitox
HKD1_k127_3155734_17	671143.DAMO_2258	1.241e-65	229.0	COG0681@1|root,COG0681@2|Bacteria,2NPIA@2323|unclassified Bacteria	2|Bacteria	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD1_k127_3155734_9	671143.DAMO_2256	8.357e-102	344.0	COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria	2|Bacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA,HrcA_DNA-bdg
HKD1_k127_3155734_22	671143.DAMO_2255	2.457e-47	177.0	COG0576@1|root,COG0576@2|Bacteria,2NPSS@2323|unclassified Bacteria	2|Bacteria	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0017076,GO:0030234,GO:0030312,GO:0030554,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036094,GO:0040007,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0050790,GO:0050896,GO:0051082,GO:0051716,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0071496,GO:0071944,GO:0097159,GO:0098772,GO:1901265,GO:1901363	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_3155734_3	671143.DAMO_2254	1.235e-154	496.0	COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0000988,GO:0000989,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006457,GO:0006458,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010556,GO:0015035,GO:0015036,GO:0016020,GO:0016032,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0016989,GO:0019219,GO:0019222,GO:0022607,GO:0031323,GO:0031326,GO:0032991,GO:0034641,GO:0034645,GO:0042026,GO:0043167,GO:0043169,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051704,GO:0055114,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0140096,GO:0140110,GO:1901360,GO:1901576,GO:1903506,GO:2001141	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_3155734_23	483219.LILAB_02945	3.225e-34	142.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,42R1A@68525|delta/epsilon subdivisions,2WMV6@28221|Deltaproteobacteria,2YVVD@29|Myxococcales	28221|Deltaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD1_k127_3155734_11	316067.Geob_2372	3.515e-81	280.0	COG0258@1|root,COG0328@1|root,COG0258@2|Bacteria,COG0328@2|Bacteria,1NRSF@1224|Proteobacteria,42YWE@68525|delta/epsilon subdivisions,2WTRZ@28221|Deltaproteobacteria,43SWB@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	5_3_exonuc,5_3_exonuc_N,RNase_H
HKD1_k127_3155734_20	671143.DAMO_2252	7.467e-49	182.0	COG0237@1|root,COG0237@2|Bacteria,2NPMB@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	GO:0003674,GO:0003824,GO:0004140,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.1.24,2.7.7.87	ko:K00859,ko:K07566	ko00770,ko01100,map00770,map01100	M00120	R00130,R10463	RC00002,RC00078,RC00745	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016	-	-	-	CoaE
HKD1_k127_3155734_24	96561.Dole_2945	1.383e-28	121.0	2FI53@1|root,349XT@2|Bacteria,1P0KG@1224|Proteobacteria,431XV@68525|delta/epsilon subdivisions,2WW9F@28221|Deltaproteobacteria,2MP20@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3155734_27	399795.CtesDRAFT_PD1596	3.379e-06	60.0	2DBPG@1|root,2ZA96@2|Bacteria,1QVNF@1224|Proteobacteria,2VP5D@28216|Betaproteobacteria,4ACJ0@80864|Comamonadaceae	28216|Betaproteobacteria	M	Domain of unknown function (DUF4382)	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,DUF4382
HKD1_k127_3155734_28	999611.KI421504_gene1125	3.23e-05	55.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TS6B@28211|Alphaproteobacteria,27ZQ1@191028|Leisingera	28211|Alphaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	htrA2	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3155734_0	671143.DAMO_2251	4.551e-247	767.0	COG1158@1|root,COG1158@2|Bacteria,2NNXC@2323|unclassified Bacteria	2|Bacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576	-	ko:K02887,ko:K03628	ko03010,ko03018,map03010,map03018	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD1_k127_3155734_25	671143.DAMO_2250	3.845e-27	112.0	COG0254@1|root,COG0254@2|Bacteria,2NPUV@2323|unclassified Bacteria	2|Bacteria	J	Binds the 23S rRNA	rpmE	GO:0008150,GO:0040007	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD1_k127_3155734_4	671143.DAMO_2249	3.345e-150	484.0	COG0216@1|root,COG0216@2|Bacteria,2NNKY@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_3155734_19	555079.Toce_2071	4.4e-60	220.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,42F18@68295|Thermoanaerobacterales	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD1_k127_3155734_2	671143.DAMO_2247	2.362e-167	535.0	COG0766@1|root,COG0766@2|Bacteria,2NNUV@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008760,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016765,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_3155734_13	671143.DAMO_2246	1.404e-77	277.0	COG0040@1|root,COG0040@2|Bacteria,2NPCD@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD1_k127_3155734_5	671143.DAMO_2245	1.488e-139	462.0	COG0141@1|root,COG0141@2|Bacteria,2NNTS@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0030145,GO:0034641,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0046914,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,1.1.1.308	ko:K00013,ko:K15509	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14140,iYO844.BSU34910	Histidinol_dh
HKD1_k127_3155734_10	671143.DAMO_2244	2.464e-84	299.0	COG0079@1|root,COG0079@2|Bacteria,2NPHF@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3155734_16	671143.DAMO_2243	1.998e-69	240.0	COG0131@1|root,COG0131@2|Bacteria,2NPI3@2323|unclassified Bacteria	2|Bacteria	E	Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004401,GO:0004424,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0040007,GO:0042578,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23,2.6.1.9,3.1.3.15,4.2.1.19	ko:K00013,ko:K00817,ko:K01089,ko:K01693	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R01158,R01163,R03012,R03013,R03243,R03457	RC00006,RC00017,RC00099,RC00242,RC00463,RC00888,RC00932	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iECO111_1330.ECO111_2746,iECS88_1305.ECS88_2121,iJN746.PP_0289,iLJ478.TM1039,iSB619.SA_RS14130,iUMNK88_1353.UMNK88_2570	Hydrolase_like,IGPD,PNK3P
HKD1_k127_3155734_15	338963.Pcar_2686	2.556e-70	248.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,42QX8@68525|delta/epsilon subdivisions,2WMNR@28221|Deltaproteobacteria,43TF4@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_3155734_12	671143.DAMO_2238	2.545e-78	269.0	COG0106@1|root,COG0106@2|Bacteria,2NPEY@2323|unclassified Bacteria	2|Bacteria	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_3155734_7	671143.DAMO_2237	8.839e-115	380.0	COG0107@1|root,COG0107@2|Bacteria,2NNMK@2323|unclassified Bacteria	2|Bacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000105,GO:0000107,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009382,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0032991,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	3.5.4.19,3.6.1.31	ko:K01663,ko:K02500,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037,R04558	RC00002,RC00010,RC01055,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_2749,iEcolC_1368.EcolC_1617,iHN637.CLJU_RS05755,iLJ478.TM1036,iSB619.SA_RS14115,iYL1228.KPN_02481	His_biosynth
HKD1_k127_3155734_18	497965.Cyan7822_0113	7.638e-65	225.0	COG1839@1|root,COG1839@2|Bacteria,1G575@1117|Cyanobacteria,3KHP9@43988|Cyanothece	1117|Cyanobacteria	S	Adenosine specific kinase	-	-	-	ko:K09129	-	-	-	-	ko00000	-	-	-	Adenosine_kin
HKD1_k127_3155734_14	671143.DAMO_2236	1.021e-75	261.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,2NPDP@2323|unclassified Bacteria	2|Bacteria	E	Phosphoribosyl-AMP cyclohydrolase	hisE	GO:0000105,GO:0000287,GO:0003674,GO:0003824,GO:0004635,GO:0004636,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009605,GO:0009607,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016810,GO:0016814,GO:0016817,GO:0016818,GO:0018130,GO:0019238,GO:0019438,GO:0019752,GO:0030312,GO:0034641,GO:0040007,GO:0043167,GO:0043169,GO:0043207,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0052803,GO:0071704,GO:0071944,GO:0075136,GO:0075139,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.4.19,3.5.4.25,3.6.1.31,5.3.1.16	ko:K01496,ko:K01497,ko:K01523,ko:K01814,ko:K11755	ko00340,ko00740,ko00790,ko01100,ko01110,ko01230,ko02024,map00340,map00740,map00790,map01100,map01110,map01230,map02024	M00026,M00125	R00425,R04035,R04037,R04640	RC00002,RC00293,RC00945,RC01055,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1897,iECNA114_1301.ECNA114_0880,iECW_1372.ECW_m2186,iEKO11_1354.EKO11_1768,iHN637.CLJU_RS05760,iSB619.SA_RS14110,iUMN146_1321.UM146_06665,iWFL_1372.ECW_m2186,iYO844.BSU34860	PRA-CH,PRA-PH
HKD1_k127_3155734_26	290397.Adeh_0718	5.434e-21	94.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_3155734_21	671143.DAMO_2759	3.032e-48	179.0	COG1610@1|root,COG1610@2|Bacteria,2NPQ9@2323|unclassified Bacteria	2|Bacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_3155734_6	292459.STH1115	5.558e-136	462.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD1_k127_3155734_8	644966.Tmar_2128	1.692e-104	362.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,3WCFZ@538999|Clostridiales incertae sedis	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD1_k127_3155734_1	1144275.COCOR_02304	1.108e-172	565.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,42N2S@68525|delta/epsilon subdivisions,2WJ0E@28221|Deltaproteobacteria,2YUHI@29|Myxococcales	28221|Deltaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_3155734_29	1444310.JANV01000190_gene4066	0.000408	43.0	29S5T@1|root,30DAB@2|Bacteria,1UB2G@1239|Firmicutes,4IMF9@91061|Bacilli,1ZK0W@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3155855_3	1120968.AUBX01000012_gene2674	2.187e-15	81.0	COG4775@1|root,COG4775@2|Bacteria,4NHNW@976|Bacteroidetes,47QHX@768503|Cytophagia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD1_k127_3155855_4	1532558.JL39_15400	3.95e-05	46.0	2D8WY@1|root,32TS4@2|Bacteria,1N2W6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3155855_1	1205680.CAKO01000025_gene4612	2.933e-77	267.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2TU46@28211|Alphaproteobacteria,2JUVN@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD1_k127_3155855_2	1123242.JH636434_gene5275	1.399e-64	226.0	COG4320@1|root,COG4320@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD1_k127_3155855_0	748247.AZKH_1971	6.898e-194	616.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_3165933_0	330214.NIDE0861	8.937e-243	768.0	COG1657@1|root,COG1657@2|Bacteria,3J0ZD@40117|Nitrospirae	40117|Nitrospirae	I	Squalene-hopene cyclase C-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD1_k127_3165933_1	316067.Geob_3665	6.943e-137	448.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,42PCW@68525|delta/epsilon subdivisions,2WMDU@28221|Deltaproteobacteria,43UIR@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF3463)	hpnH	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_3165933_2	1266925.JHVX01000004_gene1194	2.598e-60	218.0	COG2324@1|root,COG2324@2|Bacteria,1RCF6@1224|Proteobacteria,2WBQ1@28216|Betaproteobacteria,373JY@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Carotenoid biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Caroten_synth
HKD1_k127_3172060_0	1047013.AQSP01000103_gene1160	7.957e-167	535.0	COG1770@1|root,COG1770@2|Bacteria,2NNMF@2323|unclassified Bacteria	2|Bacteria	E	Prolyl oligopeptidase, N-terminal beta-propeller domain	ptrB	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0070011,GO:0070012,GO:0071704,GO:0140096,GO:1901564	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD1_k127_3173040_9	65497.JODV01000031_gene1298	2.911e-29	121.0	COG3181@1|root,COG3181@2|Bacteria,2IAFT@201174|Actinobacteria,4DZJJ@85010|Pseudonocardiales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_3173040_2	882083.SacmaDRAFT_5131	1.205e-171	561.0	COG3333@1|root,COG3333@2|Bacteria,2ICF3@201174|Actinobacteria,4DXD5@85010|Pseudonocardiales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD1_k127_3173040_8	485913.Krac_5262	2.355e-69	244.0	COG1296@1|root,COG1296@2|Bacteria,2G6SG@200795|Chloroflexi	200795|Chloroflexi	E	PFAM AzlC family protein	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
HKD1_k127_3173040_10	485913.Krac_5263	1.055e-24	116.0	COG4392@1|root,COG4392@2|Bacteria,2G7HT@200795|Chloroflexi	200795|Chloroflexi	S	Branched-chain amino acid transport protein (AzlD)	-	-	-	-	-	-	-	-	-	-	-	-	AzlD
HKD1_k127_3173040_11	204669.Acid345_3240	3.2e-07	61.0	COG1266@1|root,COG1266@2|Bacteria,3Y5CJ@57723|Acidobacteria,2JJVP@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_3173040_0	744872.Spica_2428	1.503e-269	839.0	COG0318@1|root,COG0318@2|Bacteria,2J6YC@203691|Spirochaetes	203691|Spirochaetes	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD1_k127_3173040_7	877418.ATWV01000009_gene362	1.637e-72	248.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3
HKD1_k127_3173040_3	289376.THEYE_A0114	4.089e-161	514.0	COG0473@1|root,COG0473@2|Bacteria,3J0JQ@40117|Nitrospirae	40117|Nitrospirae	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_3173040_4	1144310.PMI07_001951	7.899e-149	486.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,4B9MM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	tctA	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_3173040_12	1385511.N783_11120	2.418e-06	57.0	2E96H@1|root,333F3@2|Bacteria,1VBC5@1239|Firmicutes,4HKWQ@91061|Bacilli	91061|Bacilli	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_3173040_6	1408254.T458_15455	1.372e-82	286.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,4HBWA@91061|Bacilli,275XT@186822|Paenibacillaceae	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD1_k127_3173040_1	709797.CSIRO_0066	2.067e-194	621.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSTW@28211|Alphaproteobacteria,3JVAX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_3173040_5	709797.CSIRO_2188	9.15e-84	286.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_3173730_0	335543.Sfum_0008	1.144e-173	553.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,42MGK@68525|delta/epsilon subdivisions,2WJQH@28221|Deltaproteobacteria,2MRBU@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_3173730_1	481448.Minf_1218	2.238e-07	53.0	COG0034@1|root,COG0034@2|Bacteria,46SSU@74201|Verrucomicrobia,37G3Z@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7
HKD1_k127_3187676_15	1408254.T458_19920	7.984e-28	113.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26Q9W@186822|Paenibacillaceae	91061|Bacilli	EP	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_3187676_17	1502851.FG93_00181	1.586e-20	98.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,3K6ZS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD1_k127_3187676_9	697281.Mahau_2275	3.698e-64	229.0	COG1028@1|root,COG1028@2|Bacteria,1TPZ8@1239|Firmicutes,24903@186801|Clostridia,42GQ3@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.127,1.1.1.69	ko:K00046,ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD1_k127_3187676_4	883.DvMF_1586	1.152e-122	403.0	COG1840@1|root,COG1840@2|Bacteria,1MXZ8@1224|Proteobacteria,42P50@68525|delta/epsilon subdivisions,2WKU5@28221|Deltaproteobacteria,2MA3A@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_11,SBP_bac_6
HKD1_k127_3187676_6	883.DvMF_1587	4.86e-116	385.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2M9D3@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.30,3.6.3.31	ko:K02010,ko:K11072	ko02010,map02010	M00190,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD1_k127_3187676_0	883.DvMF_1588	1.36e-237	751.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria,2MG9C@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_3187676_3	457415.HMPREF1006_00885	1.939e-125	437.0	COG3842@1|root,COG3842@2|Bacteria,3TBZM@508458|Synergistetes	508458|Synergistetes	E	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
HKD1_k127_3187676_10	1382306.JNIM01000001_gene258	2.621e-55	203.0	COG0647@1|root,COG0647@2|Bacteria,2G6QY@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
HKD1_k127_3187676_5	671143.DAMO_3135	6.54e-118	392.0	COG0772@1|root,COG0772@2|Bacteria,2NNRP@2323|unclassified Bacteria	2|Bacteria	D	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008360,GO:0016020,GO:0022603,GO:0022604,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD1_k127_3187676_1	671143.DAMO_3134	6.275e-218	695.0	COG0768@1|root,COG0768@2|Bacteria,2NNYI@2323|unclassified Bacteria	2|Bacteria	M	Penicillin-binding protein 2	mrdA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042493,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:0071972,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0928,iEcE24377_1341.EcE24377A_0661,iPC815.YPO2604	PBP_dimer,Transpeptidase
HKD1_k127_3187676_16	671143.DAMO_3133	1.432e-26	115.0	COG2891@1|root,COG2891@2|Bacteria,2NRRJ@2323|unclassified Bacteria	2|Bacteria	M	rod shape-determining protein MreD	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD1_k127_3187676_8	671143.DAMO_3132	3.736e-67	240.0	COG1792@1|root,COG1792@2|Bacteria,2NPNX@2323|unclassified Bacteria	2|Bacteria	M	Cell shape-determining protein MreC	mreC	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007163,GO:0008150,GO:0008360,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0030428,GO:0031224,GO:0031226,GO:0042546,GO:0043621,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071554,GO:0071840,GO:0071944,GO:0071963	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD1_k127_3187676_2	671143.DAMO_3131	2.135e-189	595.0	COG1077@1|root,COG1077@2|Bacteria,2NNVU@2323|unclassified Bacteria	2|Bacteria	D	MreB/Mbl protein	mreB	GO:0000003,GO:0000910,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005856,GO:0005886,GO:0007049,GO:0008150,GO:0008360,GO:0009987,GO:0016020,GO:0019954,GO:0022402,GO:0022414,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0032505,GO:0042802,GO:0043093,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0051301,GO:0051302,GO:0051782,GO:0051983,GO:0065007,GO:0065008,GO:0071944	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_3187676_12	671143.DAMO_3130	1.345e-51	195.0	COG0760@1|root,COG0760@2|Bacteria	2|Bacteria	O	peptidyl-prolyl cis-trans isomerase activity	yacD	-	5.2.1.8	ko:K03770,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
HKD1_k127_3187676_7	237368.SCABRO_03142	1.795e-76	272.0	COG1355@1|root,COG1355@2|Bacteria,2IZEZ@203682|Planctomycetes	203682|Planctomycetes	S	Memo-like protein	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD1_k127_3187676_13	234267.Acid_6546	1.854e-35	141.0	2EC2F@1|root,3361I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3187676_11	1041139.KB902702_gene2538	9.547e-55	198.0	2E930@1|root,333BZ@2|Bacteria,1Q8B7@1224|Proteobacteria,2VEHC@28211|Alphaproteobacteria,4BE2P@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3187676_19	9778.XP_004385684.1	0.0008175	45.0	KOG1785@1|root,KOG1785@2759|Eukaryota,38BWD@33154|Opisthokonta,3BAZF@33208|Metazoa,3CRQC@33213|Bilateria,485YE@7711|Chordata,48ZCE@7742|Vertebrata,3J3GW@40674|Mammalia,354K2@311790|Afrotheria	33208|Metazoa	V	E3 ubiquitin-protein ligase CBL	CBL	GO:0000003,GO:0000209,GO:0001654,GO:0001667,GO:0001745,GO:0001751,GO:0001752,GO:0001754,GO:0001784,GO:0001894,GO:0001932,GO:0001933,GO:0002009,GO:0002064,GO:0002065,GO:0002066,GO:0002165,GO:0003002,GO:0003006,GO:0003674,GO:0003700,GO:0003824,GO:0004842,GO:0005102,GO:0005154,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005912,GO:0005924,GO:0005925,GO:0005938,GO:0006109,GO:0006355,GO:0006464,GO:0006468,GO:0006469,GO:0006508,GO:0006511,GO:0006513,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006897,GO:0006928,GO:0007154,GO:0007163,GO:0007165,GO:0007166,GO:0007167,GO:0007169,GO:0007173,GO:0007175,GO:0007176,GO:0007178,GO:0007179,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007297,GO:0007298,GO:0007389,GO:0007399,GO:0007423,GO:0007444,GO:0007465,GO:0007472,GO:0007476,GO:0007552,GO:0007560,GO:0008069,GO:0008150,GO:0008152,GO:0008270,GO:0008283,GO:0008543,GO:0009056,GO:0009057,GO:0009653,GO:0009719,GO:0009791,GO:0009798,GO:0009886,GO:0009887,GO:0009888,GO:0009889,GO:0009890,GO:0009892,GO:0009950,GO:0009953,GO:0009966,GO:0009967,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010469,GO:0010556,GO:0010563,GO:0010605,GO:0010631,GO:0010646,GO:0010647,GO:0010648,GO:0010817,GO:0010941,GO:0014066,GO:0014068,GO:0016020,GO:0016043,GO:0016192,GO:0016310,GO:0016333,GO:0016334,GO:0016477,GO:0016567,GO:0016740,GO:0017124,GO:0019219,GO:0019220,GO:0019221,GO:0019222,GO:0019538,GO:0019787,GO:0019899,GO:0019900,GO:0019901,GO:0019904,GO:0019941,GO:0019953,GO:0022008,GO:0022412,GO:0022414,GO:0023051,GO:0023052,GO:0023056,GO:0023057,GO:0030054,GO:0030055,GO:0030100,GO:0030154,GO:0030163,GO:0030182,GO:0030260,GO:0030424,GO:0030426,GO:0030427,GO:0030707,GO:0030855,GO:0030971,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0032350,GO:0032351,GO:0032353,GO:0032446,GO:0032501,GO:0032502,GO:0032504,GO:0032879,GO:0033267,GO:0033673,GO:0034097,GO:0035107,GO:0035114,GO:0035120,GO:0035220,GO:0035239,GO:0035295,GO:0035635,GO:0036211,GO:0036312,GO:0038127,GO:0040011,GO:0040027,GO:0040028,GO:0042058,GO:0042059,GO:0042127,GO:0042221,GO:0042325,GO:0042326,GO:0042592,GO:0042706,GO:0042981,GO:0042995,GO:0043005,GO:0043066,GO:0043067,GO:0043069,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043548,GO:0043549,GO:0043632,GO:0044092,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044344,GO:0044403,GO:0044409,GO:0044419,GO:0044424,GO:0044425,GO:0044444,GO:0044463,GO:0044464,GO:0044703,GO:0045121,GO:0045165,GO:0045309,GO:0045453,GO:0045466,GO:0045742,GO:0045807,GO:0045859,GO:0045936,GO:0046530,GO:0046552,GO:0046677,GO:0046849,GO:0046872,GO:0046875,GO:0046885,GO:0046914,GO:0048134,GO:0048259,GO:0048260,GO:0048468,GO:0048471,GO:0048477,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048563,GO:0048569,GO:0048580,GO:0048581,GO:0048583,GO:0048584,GO:0048585,GO:0048592,GO:0048609,GO:0048663,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048749,GO:0048771,GO:0048856,GO:0048869,GO:0048870,GO:0048871,GO:0050730,GO:0050732,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051049,GO:0051050,GO:0051093,GO:0051128,GO:0051130,GO:0051171,GO:0051172,GO:0051174,GO:0051179,GO:0051219,GO:0051234,GO:0051239,GO:0051241,GO:0051246,GO:0051248,GO:0051252,GO:0051338,GO:0051348,GO:0051603,GO:0051674,GO:0051701,GO:0051704,GO:0051716,GO:0051806,GO:0051828,GO:0060249,GO:0060255,GO:0060429,GO:0060548,GO:0060562,GO:0060627,GO:0061024,GO:0061062,GO:0061064,GO:0061097,GO:0061099,GO:0061630,GO:0061659,GO:0065007,GO:0065008,GO:0065009,GO:0070102,GO:0070161,GO:0070647,GO:0070741,GO:0070848,GO:0070849,GO:0070851,GO:0070887,GO:0071310,GO:0071345,GO:0071354,GO:0071363,GO:0071364,GO:0071495,GO:0071559,GO:0071560,GO:0071704,GO:0071774,GO:0071840,GO:0071944,GO:0080090,GO:0090130,GO:0090132,GO:0090596,GO:0097458,GO:0098589,GO:0098657,GO:0098805,GO:0098857,GO:0099568,GO:0120025,GO:0120038,GO:0140096,GO:0140110,GO:0150034,GO:1901184,GO:1901185,GO:1901186,GO:1901214,GO:1901215,GO:1901564,GO:1901565,GO:1901575,GO:1902531,GO:1902533,GO:1903506,GO:1990782,GO:2000026,GO:2000112,GO:2000272,GO:2001141	2.3.2.27	ko:K04707	ko04012,ko04120,ko04144,ko04660,ko04910,ko05100,ko05200,ko05205,ko05220,map04012,map04120,map04144,map04660,map04910,map05100,map05200,map05205,map05220	-	-	-	ko00000,ko00001,ko01000,ko04121,ko04131	-	-	-	Cbl_N,Cbl_N2,Cbl_N3,Prok-RING_4,UBA
HKD1_k127_3187676_18	1210884.HG799471_gene14682	2.045e-06	57.0	COG0500@1|root,COG2226@2|Bacteria,2J1IZ@203682|Planctomycetes	203682|Planctomycetes	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3194053_0	118168.MC7420_8133	2.912e-266	833.0	COG3387@1|root,COG3387@2|Bacteria,1G3VS@1117|Cyanobacteria,1H860@1150|Oscillatoriales	1117|Cyanobacteria	G	Glycosyl hydrolases family 15	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD1_k127_3194053_4	671143.DAMO_1538	1.644e-57	207.0	COG0668@1|root,COG0668@2|Bacteria,2NQ6B@2323|unclassified Bacteria	2|Bacteria	M	transmembrane transport	cmpX	-	-	-	-	-	-	-	-	-	-	-	MS_channel,TM_helix
HKD1_k127_3194053_3	671143.DAMO_1539	3.958e-67	244.0	COG0463@1|root,COG0463@2|Bacteria,2NQD9@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	2.4.1.268	ko:K21349	-	-	-	-	ko00000,ko01000	-	GT81	-	Glycos_transf_2
HKD1_k127_3194053_1	909663.KI867151_gene3002	1.213e-119	412.0	COG0438@1|root,COG0438@2|Bacteria,1MYTB@1224|Proteobacteria,42MCA@68525|delta/epsilon subdivisions,2WJVX@28221|Deltaproteobacteria,2MQT9@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
HKD1_k127_3194053_5	525903.Taci_0298	1.17e-24	121.0	COG0438@1|root,COG0438@2|Bacteria,3TC5G@508458|Synergistetes	508458|Synergistetes	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3194053_2	1128421.JAGA01000003_gene2942	2.803e-85	308.0	COG3281@1|root,COG3281@2|Bacteria,2NR3X@2323|unclassified Bacteria	2|Bacteria	G	Phosphotransferase enzyme family	treS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0005984,GO:0005991,GO:0005992,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009058,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016310,GO:0034637,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044424,GO:0044444,GO:0044464,GO:0046351,GO:0046835,GO:0071704,GO:0071944,GO:1901576	2.4.1.18,2.7.1.175,3.2.1.1,5.4.99.16	ko:K00700,ko:K05343,ko:K16146	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01557,R02108,R02110,R02112,R09945,R11262	RC00002,RC00078,RC01816	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	APH,Alpha-amylase,Malt_amylase_C
HKD1_k127_3200268_1	1042326.AZNV01000031_gene3667	1.932e-122	405.0	COG0475@1|root,COG0475@2|Bacteria,1PK6R@1224|Proteobacteria,2UA1A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_3200268_2	338966.Ppro_1433	4.689e-59	213.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2X2H8@28221|Deltaproteobacteria,43VFB@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_3200268_3	1205680.CAKO01000030_gene4866	6.807e-30	126.0	2CPI3@1|root,32SJ7@2|Bacteria,1N1IR@1224|Proteobacteria,2UBVS@28211|Alphaproteobacteria,2JX60@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF992)	-	-	-	-	-	-	-	-	-	-	-	-	DUF992
HKD1_k127_3200268_0	765952.PUV_21540	7.242e-303	936.0	COG3119@1|root,COG3119@2|Bacteria,2JGPY@204428|Chlamydiae	204428|Chlamydiae	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_3203902_3	1267534.KB906755_gene4106	4.96e-09	60.0	COG1208@1|root,COG1208@2|Bacteria,3Y2MI@57723|Acidobacteria,2JI1C@204432|Acidobacteriia	204432|Acidobacteriia	JM	Glucose-1-phosphate cytidylyltransferase	-	-	2.7.7.33	ko:K00978	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R00956	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HKD1_k127_3203902_2	215803.DB30_4272	9.439e-84	292.0	COG0399@1|root,COG0515@1|root,COG0399@2|Bacteria,COG0515@2|Bacteria,1MUMJ@1224|Proteobacteria,43BZX@68525|delta/epsilon subdivisions,2X7AP@28221|Deltaproteobacteria,2YXNP@29|Myxococcales	28221|Deltaproteobacteria	M	Putative transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y2_Tnp
HKD1_k127_3203902_1	1267534.KB906754_gene3076	9.207e-86	299.0	2ART5@1|root,31H4G@2|Bacteria,3Y848@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3203902_0	1245469.S58_28530	8.56e-155	498.0	COG4641@1|root,COG4641@2|Bacteria,1RK42@1224|Proteobacteria,2U7VU@28211|Alphaproteobacteria,3JZKD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2
HKD1_k127_3216293_20	1394178.AWOO02000054_gene7982	0.0004646	47.0	COG0819@1|root,COG0819@2|Bacteria,2I9CY@201174|Actinobacteria	201174|Actinobacteria	K	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway	-	-	-	-	-	-	-	-	-	-	-	-	TENA_THI-4
HKD1_k127_3216293_3	309801.trd_A0407	2.821e-157	505.0	COG3964@1|root,COG3964@2|Bacteria,2G7WR@200795|Chloroflexi,27XRM@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_3216293_1	797209.ZOD2009_14406	1.37e-172	552.0	COG2421@1|root,arCOG01004@2157|Archaea,2XTXT@28890|Euryarchaeota,23SNN@183963|Halobacteria	183963|Halobacteria	C	Acetamidase formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HKD1_k127_3216293_14	324602.Caur_3886	1.711e-55	203.0	COG2129@1|root,COG2129@2|Bacteria,2G8MC@200795|Chloroflexi,375QR@32061|Chloroflexia	32061|Chloroflexia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_3216293_12	1128421.JAGA01000001_gene2083	6.473e-75	261.0	COG1475@1|root,COG1475@2|Bacteria,2NS1X@2323|unclassified Bacteria	2|Bacteria	K	DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032,ParBc
HKD1_k127_3216293_17	309799.DICTH_1288	9.813e-17	85.0	COG1254@1|root,COG1254@2|Bacteria	2|Bacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0016787,GO:0016817,GO:0016818,GO:0050896	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS07020,iSBO_1134.SBO_2263,iSF_1195.SF0969,iSFxv_1172.SFxv_1053,iS_1188.S1036	Acylphosphatase
HKD1_k127_3216293_13	671143.DAMO_1377	2.043e-72	247.0	COG0503@1|root,COG0503@2|Bacteria,2NPGX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	PRTase_2,Pribosyltran,TRSP
HKD1_k127_3216293_19	393921.HQ45_01295	0.0001991	51.0	COG0457@1|root,COG1729@1|root,COG2956@1|root,COG4105@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,COG2956@2|Bacteria,COG4105@2|Bacteria,4NE4W@976|Bacteroidetes,2FM3C@200643|Bacteroidia,22X5K@171551|Porphyromonadaceae	976|Bacteroidetes	G	Tetratricopeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_21,TPR_6,TPR_8
HKD1_k127_3216293_15	1463895.JODA01000026_gene5415	1.537e-25	112.0	COG0745@1|root,COG0745@2|Bacteria,2GK5S@201174|Actinobacteria	201174|Actinobacteria	T	response regulator, receiver	resD	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_3216293_16	1230460.C495_01845	2.341e-25	121.0	COG0477@1|root,arCOG00134@2157|Archaea,2Y8EE@28890|Euryarchaeota,2419Q@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_3216293_2	926569.ANT_12900	6.977e-158	506.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q1@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3216293_5	926569.ANT_12890	1.238e-135	443.0	COG0559@1|root,COG0559@2|Bacteria,2G6FM@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_3216293_6	926569.ANT_12880	1.037e-119	400.0	COG4177@1|root,COG4177@2|Bacteria,2G6D8@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_3216293_7	926569.ANT_12870	7.58e-114	372.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_3216293_10	1121468.AUBR01000032_gene1193	1.64e-102	339.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,42EMQ@68295|Thermoanaerobacterales	186801|Clostridia	E	ABC transporter related	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_3216293_0	335543.Sfum_3244	5.675e-204	643.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MRBG@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_3216293_4	1191523.MROS_2798	2.263e-153	513.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transf_2,PPDK_N,Response_reg
HKD1_k127_3216293_11	204773.HEAR1081	1.509e-93	316.0	COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria,474I0@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD1_k127_3216293_8	246197.MXAN_0722	7.699e-114	374.0	COG1682@1|root,COG1682@2|Bacteria,1QXTH@1224|Proteobacteria,42XN1@68525|delta/epsilon subdivisions,2WSPR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_3216293_9	404589.Anae109_1617	9.023e-107	349.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42ZGK@68525|delta/epsilon subdivisions,2WUTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3229372_13	1499967.BAYZ01000095_gene4129	5.589e-11	75.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_3229372_4	392499.Swit_1884	1.025e-114	382.0	COG0673@1|root,COG0673@2|Bacteria,1NVJK@1224|Proteobacteria,2U0NE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	MA20_02630	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_3229372_8	402777.KB235903_gene2437	7.734e-68	246.0	COG0745@1|root,COG5002@1|root,COG0745@2|Bacteria,COG5002@2|Bacteria,1GBPX@1117|Cyanobacteria	1117|Cyanobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_3229372_1	671143.DAMO_2072	1.001e-205	670.0	COG1075@1|root,COG4995@1|root,COG1075@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_12
HKD1_k127_3229372_3	671143.DAMO_2073	4.195e-119	394.0	COG4249@1|root,COG4249@2|Bacteria,2NQXX@2323|unclassified Bacteria	2|Bacteria	S	Caspase domain	atmc2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HKD1_k127_3229372_0	671143.DAMO_2917	0.0	1409.0	COG0667@1|root,COG1331@1|root,COG0667@2|Bacteria,COG1331@2|Bacteria,2NP26@2323|unclassified Bacteria	2|Bacteria	O	Protein of unknown function, DUF255	yyaL	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_3229372_10	671143.DAMO_2130	8.005e-50	185.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	sscB	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_3229372_7	397948.Cmaq_0649	8.33e-89	301.0	COG1082@1|root,arCOG01895@2157|Archaea	2157|Archaea	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	5.1.3.30,5.1.3.31	ko:K18910	-	-	R10817,R10818	RC03111,RC03283	ko00000,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_3229372_5	309801.trd_0006	5.428e-106	358.0	COG1171@1|root,COG1171@2|Bacteria,2G5YN@200795|Chloroflexi,27XYI@189775|Thermomicrobia	189775|Thermomicrobia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3229372_12	671143.DAMO_1987	7.357e-24	107.0	COG2259@1|root,COG2259@2|Bacteria,2NQ4C@2323|unclassified Bacteria	2|Bacteria	S	DoxX	ndh	-	1.6.99.3,1.8.5.2	ko:K03885,ko:K16937	ko00190,ko00920,ko01120,map00190,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxD,DoxX,Pyr_redox_2
HKD1_k127_3229372_9	671143.DAMO_1263	1.18e-58	205.0	COG0780@1|root,COG0780@2|Bacteria,2NPZV@2323|unclassified Bacteria	2|Bacteria	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD1_k127_3229372_6	335543.Sfum_2007	1.702e-93	317.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,42N90@68525|delta/epsilon subdivisions,2WJUU@28221|Deltaproteobacteria,2MRIT@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_3229372_2	335543.Sfum_2006	6.214e-132	437.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,42QF7@68525|delta/epsilon subdivisions,2WJAU@28221|Deltaproteobacteria,2MQKF@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K07644	ko02020,map02020	M00452,M00745	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko01504,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS_9,Response_reg
HKD1_k127_3244261_0	1128427.KB904821_gene3548	1.001e-190	615.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1G40A@1117|Cyanobacteria,1HI0P@1150|Oscillatoriales	1117|Cyanobacteria	P	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
HKD1_k127_3244261_2	426355.Mrad2831_1922	7.835e-29	119.0	2CI53@1|root,2ZTP9@2|Bacteria,1R3BG@1224|Proteobacteria,2U75J@28211|Alphaproteobacteria,1JV5R@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3244261_6	398767.Glov_3620	1.617e-06	57.0	2C6P2@1|root,33C1K@2|Bacteria,1NI6K@1224|Proteobacteria,42WBY@68525|delta/epsilon subdivisions,2WRCU@28221|Deltaproteobacteria,43VJ1@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD1_k127_3244261_1	56780.SYN_01206	1.241e-74	259.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,42TGK@68525|delta/epsilon subdivisions,2WRH2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	alpha beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_6,Hydrolase_4
HKD1_k127_3244261_5	880072.Desac_0965	8.227e-16	85.0	COG1433@1|root,COG1433@2|Bacteria,1PX8P@1224|Proteobacteria,434CZ@68525|delta/epsilon subdivisions,2X35B@28221|Deltaproteobacteria,2MRZJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD1_k127_3244261_4	931626.Awo_c06690	2.779e-20	93.0	COG2043@1|root,COG2043@2|Bacteria	2|Bacteria	C	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_3244261_3	555088.DealDRAFT_2708	5.482e-23	104.0	COG2043@1|root,COG2043@2|Bacteria,1TT5P@1239|Firmicutes,25NSU@186801|Clostridia,42K8T@68298|Syntrophomonadaceae	186801|Clostridia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_3251007_5	398767.Glov_3457	8.105e-20	95.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,42PV9@68525|delta/epsilon subdivisions	1224|Proteobacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	clsA	GO:0003674,GO:0003824,GO:0008808,GO:0016740,GO:0016772,GO:0016780,GO:0030572	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_3078	PLDc_2,PLDc_N
HKD1_k127_3251007_1	255470.cbdbA813	1.914e-191	613.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,34CWN@301297|Dehalococcoidia	301297|Dehalococcoidia	H	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_3251007_0	398767.Glov_1468	1.1e-208	670.0	COG3291@1|root,COG3291@2|Bacteria,1NS55@1224|Proteobacteria,43CPJ@68525|delta/epsilon subdivisions,2X7WV@28221|Deltaproteobacteria	1224|Proteobacteria	C	Chitobiase/beta-hexosaminidase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,Cytochrome_cB
HKD1_k127_3251007_3	1504672.669783786	3.642e-143	463.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,4ACKS@80864|Comamonadaceae	28216|Betaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HKD1_k127_3251007_4	365046.Rta_32000	1.273e-126	412.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2VJHU@28216|Betaproteobacteria,4A9S6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_3251007_2	62928.azo2862	2.852e-165	525.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria,2KW6R@206389|Rhodocyclales	206389|Rhodocyclales	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_3258660_5	1041930.Mtc_0336	1.63e-41	161.0	COG0610@1|root,arCOG00879@2157|Archaea,2Y7GI@28890|Euryarchaeota,2N9MN@224756|Methanomicrobia	224756|Methanomicrobia	V	Type III restriction	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N,ResIII
HKD1_k127_3258660_3	96561.Dole_3137	3.809e-167	534.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,42NJU@68525|delta/epsilon subdivisions,2WKA6@28221|Deltaproteobacteria,2MJK5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HKD1_k127_3258660_0	269799.Gmet_3159	5.978e-320	1003.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_3258660_1	330214.NIDE1508	3.182e-273	865.0	COG2203@1|root,COG2804@1|root,COG2203@2|Bacteria,COG2804@2|Bacteria,3J0XR@40117|Nitrospirae	40117|Nitrospirae	NU	Type II/IV secretion system protein	-	-	-	ko:K02454,ko:K02652	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSE,T2SSE_N
HKD1_k127_3258660_2	671143.DAMO_2970	2.417e-218	693.0	COG0322@1|root,COG0322@2|Bacteria,2NNQ4@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016787,GO:0016788,GO:0030312,GO:0031668,GO:0032991,GO:0033554,GO:0034641,GO:0040007,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD1_k127_3258660_4	247490.KSU1_C0571	4.045e-68	244.0	COG2204@1|root,COG2204@2|Bacteria,2IY95@203682|Planctomycetes	203682|Planctomycetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3273353_1	748247.AZKH_1971	2.843e-82	277.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_3273353_0	1267534.KB906755_gene4600	2.924e-125	412.0	28ITY@1|root,2Z8SS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3279306_2	671143.DAMO_2692	2.562e-118	390.0	COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015672,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0051179,GO:0051234,GO:0055085,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00341,ko:K12137	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	e_coli_core.b2278,iAF1260.b2278,iBWG_1329.BWG_2052,iECDH10B_1368.ECDH10B_2440,iECDH1ME8569_1439.ECDH1ME8569_2215,iEcDH1_1363.EcDH1_1379,iJN746.PP_4129,iJO1366.b2278,iJR904.b2278,iY75_1357.Y75_RS11945	Proton_antipo_M,Proton_antipo_N
HKD1_k127_3279306_0	671143.DAMO_2691	1.241e-204	649.0	COG1008@1|root,COG1008@2|Bacteria,2NNQ9@2323|unclassified Bacteria	2|Bacteria	C	NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD1_k127_3279306_1	247490.KSU1_D0315	4.598e-149	487.0	COG1007@1|root,COG1007@2|Bacteria,2IXC6@203682|Planctomycetes	203682|Planctomycetes	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_3279306_3	671143.DAMO_2689	4.931e-91	304.0	COG2344@1|root,COG2344@2|Bacteria,2NPI1@2323|unclassified Bacteria	2|Bacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HKD1_k127_3279306_4	880072.Desac_2016	3.226e-53	191.0	COG4747@1|root,COG4747@2|Bacteria,1RDCG@1224|Proteobacteria,42RTD@68525|delta/epsilon subdivisions,2WNC2@28221|Deltaproteobacteria,2MRPV@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD1_k127_3279306_5	941449.dsx2_2930	1.742e-15	80.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
HKD1_k127_3280499_0	1173022.Cri9333_0468	1.887e-225	713.0	COG0296@1|root,COG0296@2|Bacteria,1G4X2@1117|Cyanobacteria,1H8Y0@1150|Oscillatoriales	1117|Cyanobacteria	G	Alpha amylase, C-terminal all-beta domain	-	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_3280499_6	1173022.Cri9333_0463	1.965e-05	48.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K14673	-	-	-	-	ko00000,ko01008	-	-	-	Cupin_2
HKD1_k127_3280499_4	886293.Sinac_3965	4.179e-25	108.0	COG0724@1|root,COG0724@2|Bacteria,2IZPY@203682|Planctomycetes	203682|Planctomycetes	S	PFAM RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3280499_1	316067.Geob_1378	5.587e-80	279.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,42MTK@68525|delta/epsilon subdivisions,2WM8U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD1_k127_3280499_2	316067.Geob_1379	4.12e-45	175.0	COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,43CDH@68525|delta/epsilon subdivisions,2X7PC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_3280499_5	316067.Geob_1379	8.425e-13	72.0	COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,43CDH@68525|delta/epsilon subdivisions,2X7PC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_3280499_3	1380390.JIAT01000010_gene4081	2.29e-32	127.0	COG2267@1|root,COG2267@2|Bacteria,2GJ78@201174|Actinobacteria,4CSBE@84995|Rubrobacteria	84995|Rubrobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_3283083_1	886293.Sinac_1231	6.124e-45	165.0	COG3464@1|root,COG3464@2|Bacteria,2J4EX@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3283083_0	314230.DSM3645_26134	6.539e-107	358.0	COG5433@1|root,COG5433@2|Bacteria,2IWUI@203682|Planctomycetes	203682|Planctomycetes	L	COG5433 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_3283083_2	667015.Bacsa_0522	3.508e-08	60.0	COG0714@1|root,COG0714@2|Bacteria,4NJZG@976|Bacteroidetes,2FNHD@200643|Bacteroidia,4AMSJ@815|Bacteroidaceae	976|Bacteroidetes	S	COG NOG11635 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	DUF3987
HKD1_k127_3289734_2	391625.PPSIR1_27758	3.158e-98	325.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,42MXV@68525|delta/epsilon subdivisions,2WIIT@28221|Deltaproteobacteria,2YY6V@29|Myxococcales	28221|Deltaproteobacteria	C	Pyruvate flavodoxin ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD1_k127_3289734_1	530564.Psta_0806	2.287e-143	462.0	COG1013@1|root,COG1013@2|Bacteria,2IY6Z@203682|Planctomycetes	203682|Planctomycetes	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD1_k127_3289734_0	671143.DAMO_3171	1.301e-167	539.0	COG0277@1|root,COG0277@2|Bacteria,2NP2P@2323|unclassified Bacteria	2|Bacteria	C	FAD linked oxidases, C-terminal domain	glcD	GO:0003674,GO:0003824,GO:0006066,GO:0006082,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009441,GO:0009987,GO:0016054,GO:0016491,GO:0016614,GO:0017144,GO:0019154,GO:0019752,GO:0032787,GO:0033554,GO:0034308,GO:0034310,GO:0042737,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046164,GO:0046296,GO:0046395,GO:0050896,GO:0051716,GO:0055114,GO:0071704,GO:0072329,GO:1901575,GO:1901615,GO:1901616	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	iJN746.PP_3745,iLF82_1304.LF82_0831,iNRG857_1313.NRG857_14750	FAD-oxidase_C,FAD_binding_4
HKD1_k127_3289734_3	671143.DAMO_3172	2.919e-69	249.0	COG0277@1|root,COG0277@2|Bacteria,2NP55@2323|unclassified Bacteria	2|Bacteria	C	FAD binding domain	glcE	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_3315602_4	1038859.AXAU01000002_gene334	0.0001024	46.0	COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria,3JVI6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3315602_0	189753.AXAS01000058_gene153	7.81e-193	632.0	COG1129@1|root,COG4177@1|root,COG1129@2|Bacteria,COG4177@2|Bacteria,1R9IW@1224|Proteobacteria,2TWGB@28211|Alphaproteobacteria,3K6KK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD1_k127_3315602_1	1217720.ALOX01000037_gene2906	9.502e-91	308.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria,2JR66@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_3315602_2	1411123.JQNH01000001_gene3176	1.593e-73	255.0	COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3315602_3	1188256.BASI01000001_gene945	1.389e-07	53.0	COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3333505_2	1340493.JNIF01000003_gene3717	2.635e-91	317.0	28S8C@1|root,2ZEJQ@2|Bacteria,3Y4E5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3333505_1	720554.Clocl_1256	5.748e-151	488.0	COG1850@1|root,COG1850@2|Bacteria,1TSZQ@1239|Firmicutes,2482N@186801|Clostridia	186801|Clostridia	G	Belongs to the RuBisCO large chain family	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
HKD1_k127_3333505_0	639030.JHVA01000001_gene925	0.0	1492.0	COG1201@1|root,COG1201@2|Bacteria,3Y3XA@57723|Acidobacteria,2JHMF@204432|Acidobacteriia	204432|Acidobacteriia	L	DEAD DEAH box	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_42,Helicase_C
HKD1_k127_3333505_3	290397.Adeh_2091	3.098e-62	224.0	COG0266@1|root,COG0266@2|Bacteria,1N1J5@1224|Proteobacteria,433TA@68525|delta/epsilon subdivisions,2X3D6@28221|Deltaproteobacteria,2YVHV@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the FPG family	-	-	4.2.99.18	ko:K05522	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD1_k127_3333505_4	909663.KI867150_gene367	2.502e-11	71.0	COG2911@1|root,COG2911@2|Bacteria,1MW9V@1224|Proteobacteria,42U7P@68525|delta/epsilon subdivisions,2WQKY@28221|Deltaproteobacteria,2MQSP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3345801_4	1125725.HMPREF1325_1474	1.963e-05	47.0	COG1593@1|root,COG1593@2|Bacteria,2J6K2@203691|Spirochaetes	203691|Spirochaetes	G	transporter, DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_3345801_3	883.DvMF_2930	6.672e-47	179.0	COG1802@1|root,COG1802@2|Bacteria,1N7GE@1224|Proteobacteria,43AVA@68525|delta/epsilon subdivisions,2X5U1@28221|Deltaproteobacteria,2ME3Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_3345801_2	1040989.AWZU01000003_gene6625	2.957e-116	388.0	COG1653@1|root,COG1653@2|Bacteria,1R5NT@1224|Proteobacteria,2TTRQ@28211|Alphaproteobacteria,3JSBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_3345801_1	1040989.AWZU01000003_gene6625	1.772e-128	426.0	COG1653@1|root,COG1653@2|Bacteria,1R5NT@1224|Proteobacteria,2TTRQ@28211|Alphaproteobacteria,3JSBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_3345801_0	1125973.JNLC01000012_gene987	1.587e-139	454.0	COG4091@1|root,COG4091@2|Bacteria,1MUZX@1224|Proteobacteria,2TRZ0@28211|Alphaproteobacteria,3JSZI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	SAF	MA20_06800	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA,NAD_binding_3,SAF
HKD1_k127_3349417_17	1121861.KB899934_gene487	3.06e-62	218.0	COG1921@1|root,COG1921@2|Bacteria,1MW8F@1224|Proteobacteria,2TSR8@28211|Alphaproteobacteria,2JYRT@204441|Rhodospirillales	204441|Rhodospirillales	E	L-seryl-tRNA selenium transferase	-	-	-	-	-	-	-	-	-	-	-	-	SelA
HKD1_k127_3349417_10	1082933.MEA186_20574	1.335e-103	344.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,2TQX2@28211|Alphaproteobacteria,43ICT@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	glnQ	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
HKD1_k127_3349417_14	420324.KI911943_gene5281	3.603e-75	271.0	COG0765@1|root,COG0765@2|Bacteria,1RBI8@1224|Proteobacteria,2U6FS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD1_k127_3349417_12	420324.KI911943_gene5282	1.366e-94	314.0	COG0765@1|root,COG0765@2|Bacteria,1RA2Q@1224|Proteobacteria,2U63Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	ABC transporter (Permease)	-	-	-	ko:K02029	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD1_k127_3349417_6	1082933.MEA186_20589	3.122e-118	387.0	COG0834@1|root,COG0834@2|Bacteria,1RC5X@1224|Proteobacteria,2U5YC@28211|Alphaproteobacteria,43JUH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	ET	Bacterial extracellular solute-binding proteins, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_3349417_16	1219084.AP014508_gene186	1.21e-62	225.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_3349417_22	883.DvMF_1180	9.75e-38	147.0	COG4087@1|root,COG4087@2|Bacteria,1N05K@1224|Proteobacteria,42U05@68525|delta/epsilon subdivisions,2WQDW@28221|Deltaproteobacteria,2MBNV@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	COGs COG4087 Soluble P-type ATPase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase,Hydrolase_3
HKD1_k127_3349417_23	383372.Rcas_0720	1.064e-36	147.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3349417_27	383372.Rcas_0721	5.052e-18	86.0	COG0011@1|root,COG0011@2|Bacteria	2|Bacteria	H	TIGRFAM Protein of	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP,Ykof
HKD1_k127_3349417_7	1499967.BAYZ01000078_gene1005	9.624e-115	379.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_3349417_4	635013.TherJR_1813	1.67e-127	418.0	COG0436@1|root,COG0436@2|Bacteria,1TQD6@1239|Firmicutes,2491B@186801|Clostridia,260Z9@186807|Peptococcaceae	186801|Clostridia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	dapL	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3349417_21	497964.CfE428DRAFT_3622	3.327e-49	179.0	COG1765@1|root,COG1765@2|Bacteria,46T1Y@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_3349417_25	525904.Tter_2739	6.517e-28	120.0	COG4315@1|root,COG4315@2|Bacteria	2|Bacteria	P	Pfam Secreted repeat of	MA20_31645	-	-	ko:K19519	-	-	-	-	ko00000,ko04516	-	-	-	Lipoprotein_15
HKD1_k127_3349417_13	1210884.HG799465_gene12277	1.605e-77	267.0	COG1834@1|root,COG1834@2|Bacteria,2IXSX@203682|Planctomycetes	203682|Planctomycetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD1_k127_3349417_8	886293.Sinac_5339	2.657e-114	393.0	COG1915@1|root,COG1915@2|Bacteria,2IWVZ@203682|Planctomycetes	203682|Planctomycetes	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HKD1_k127_3349417_18	370438.PTH_1534	1.027e-58	213.0	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,261MU@186807|Peptococcaceae	186801|Clostridia	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3
HKD1_k127_3349417_3	1123368.AUIS01000014_gene2282	6.78e-129	422.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome c peroxidase	ccpA	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD1_k127_3349417_29	1304877.KI519399_gene3351	4.921e-16	81.0	COG2010@1|root,COG2010@2|Bacteria,1NC9D@1224|Proteobacteria,2UGP9@28211|Alphaproteobacteria,3JZM8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3349417_2	1235457.C404_16175	1.59e-137	448.0	COG2041@1|root,COG2041@2|Bacteria,1MX9E@1224|Proteobacteria,2VK72@28216|Betaproteobacteria,1JZY2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	C oxidoreductase subunit A	sorA	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD1_k127_3349417_24	313596.RB2501_04755	5.328e-30	125.0	COG2010@1|root,COG2010@2|Bacteria,4NRFW@976|Bacteroidetes,1I3K8@117743|Flavobacteriia	976|Bacteroidetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_3349417_28	323848.Nmul_A0869	2.433e-16	85.0	2DP14@1|root,3303I@2|Bacteria,1N7JW@1224|Proteobacteria,2VW7N@28216|Betaproteobacteria,373MI@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3349417_30	706587.Desti_3697	2.782e-07	62.0	COG1283@1|root,COG1283@2|Bacteria,1NYQQ@1224|Proteobacteria,430T2@68525|delta/epsilon subdivisions,2WW13@28221|Deltaproteobacteria,2MSGK@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	sodium-dependent phosphate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3349417_9	1009370.ALO_19362	4.435e-106	351.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H2E8@909932|Negativicutes	1239|Firmicutes	E	ABC transporter, ATP-binding protein	-	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
HKD1_k127_3349417_20	1137799.GZ78_16370	1.702e-55	202.0	COG0765@1|root,COG0765@2|Bacteria,1MX3E@1224|Proteobacteria,1RS0Y@1236|Gammaproteobacteria,1XJ30@135619|Oceanospirillales	135619|Oceanospirillales	P	ABC transporter	glnP	-	-	ko:K02029,ko:K10037	ko02010,map02010	M00227,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.2	-	-	BPD_transp_1
HKD1_k127_3349417_5	1009370.ALO_19372	1.325e-121	399.0	COG0834@1|root,COG0834@2|Bacteria,1TQUG@1239|Firmicutes,4H1US@909932|Negativicutes	909932|Negativicutes	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3
HKD1_k127_3349417_1	1499967.BAYZ01000177_gene5725	3.349e-191	617.0	COG1053@1|root,COG1053@2|Bacteria,2NQEG@2323|unclassified Bacteria	2|Bacteria	C	FAD binding domain	-	-	1.4.3.16,1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K00278,ko:K03388	ko00250,ko00680,ko00760,ko01100,ko01120,ko01200,map00250,map00680,map00760,map01100,map01120,map01200	M00115,M00356,M00357,M00563,M00567	R00357,R00481,R04540,R11928,R11931,R11943,R11944	RC00006,RC00011,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2
HKD1_k127_3349417_19	1392490.JHZX01000001_gene210	4.292e-57	218.0	COG4775@1|root,COG4775@2|Bacteria,4NMIQ@976|Bacteroidetes,1I1IX@117743|Flavobacteriia	976|Bacteroidetes	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD1_k127_3349417_26	1408418.JNJH01000041_gene729	6.259e-19	88.0	COG3394@1|root,COG3394@2|Bacteria,1PP39@1224|Proteobacteria,2U2UW@28211|Alphaproteobacteria,2JSM3@204441|Rhodospirillales	204441|Rhodospirillales	G	YdjC-like protein	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HKD1_k127_3349417_0	1162668.LFE_1152	1.161e-256	801.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	bchE	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
HKD1_k127_3349417_11	756067.MicvaDRAFT_5296	7.796e-96	320.0	COG1028@1|root,COG1028@2|Bacteria,1G0IE@1117|Cyanobacteria	1117|Cyanobacteria	IQ	PFAM short chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_3349417_15	1274374.CBLK010000083_gene3788	5.04e-63	227.0	COG2220@1|root,COG2220@2|Bacteria,1TSFV@1239|Firmicutes,4HBNW@91061|Bacilli,26TE3@186822|Paenibacillaceae	91061|Bacilli	S	Beta-lactamase superfamily domain	ulaG	-	-	ko:K03476	ko00053,ko01100,ko01120,map00053,map01100,map01120	M00550	R07677	RC02793	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactamase_B_2,Lactamase_B_3
HKD1_k127_3367990_0	1411123.JQNH01000001_gene3657	4.743e-234	743.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG1529 Aerobic-type carbon monoxide dehydrogenase large subunit CoxL CutL homologs	MA20_17495	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HKD1_k127_3367990_3	1298858.AUEL01000007_gene2371	1.311e-64	224.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	COG2080 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS CutS homologs	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_3367990_1	204669.Acid345_3257	2.12e-157	506.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria,2JHSR@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
HKD1_k127_3367990_2	1267535.KB906767_gene4009	1.224e-141	458.0	COG1239@1|root,COG1239@2|Bacteria,3Y3FM@57723|Acidobacteria,2JHY2@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in chlorophyll biosynthesis. Catalyzes the insertion of magnesium ion into protoporphyrin IX to yield Mg- protoporphyrin IX	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	Sigma54_activat
HKD1_k127_3369754_13	416591.Tlet_0853	4.549e-10	63.0	COG0747@1|root,COG0747@2|Bacteria,2GC9E@200918|Thermotogae	200918|Thermotogae	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_3369754_3	1499967.BAYZ01000160_gene407	2.723e-119	392.0	COG0601@1|root,COG0601@2|Bacteria	2|Bacteria	P	nitrogen compound transport	dppB	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_3369754_7	1499967.BAYZ01000160_gene410	5.702e-102	359.0	COG1173@1|root,COG1173@2|Bacteria,2NQ14@2323|unclassified Bacteria	2|Bacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	dppC	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02034,ko:K12370	ko02010,ko02024,map02010,map02024	M00239,M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_3369754_6	1121861.KB899937_gene4028	2.841e-104	348.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,2JP9V@204441|Rhodospirillales	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
HKD1_k127_3369754_5	215803.DB30_0768	1.742e-105	352.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,42TDH@68525|delta/epsilon subdivisions,2WIQT@28221|Deltaproteobacteria,2YU5K@29|Myxococcales	28221|Deltaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_3369754_4	342949.PNA2_1651	3.01e-107	362.0	COG2355@1|root,arCOG04083@2157|Archaea,2XUXV@28890|Euryarchaeota,242R0@183968|Thermococci	183968|Thermococci	E	Membrane dipeptidase (Peptidase family M19)	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_3369754_8	713586.KB900536_gene78	8.599e-66	234.0	COG2159@1|root,COG2159@2|Bacteria,1R44U@1224|Proteobacteria,1SZYU@1236|Gammaproteobacteria,1X1U1@135613|Chromatiales	135613|Chromatiales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_3369754_17	1233951.IO90_02755	0.0002171	48.0	COG2026@1|root,COG2026@2|Bacteria,4NVIF@976|Bacteroidetes,1I5T2@117743|Flavobacteriia	976|Bacteroidetes	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_3369754_16	933262.AXAM01000013_gene1308	6.587e-06	48.0	COG2442@1|root,COG2442@2|Bacteria,1N96I@1224|Proteobacteria,42VWX@68525|delta/epsilon subdivisions,2X6NY@28221|Deltaproteobacteria,2MP3C@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_3369754_14	237368.SCABRO_03797	1.053e-09	61.0	293PF@1|root,2ZR54@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3369754_12	572477.Alvin_1301	3.429e-21	98.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	ycnE	GO:0003674,GO:0003824	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	ABM
HKD1_k127_3369754_1	671143.DAMO_2457	1.261e-281	873.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_3369754_10	671143.DAMO_2458	1.983e-41	156.0	COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_3369754_2	316067.Geob_0176	6.34e-155	506.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y50@68525|delta/epsilon subdivisions,2WUBF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HTH_8,PAS_4,Sigma54_activat
HKD1_k127_3369754_9	1499967.BAYZ01000034_gene1071	7.497e-49	178.0	2E46N@1|root,32Z2M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3369754_15	1117379.BABA_20751	2.489e-07	60.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,4HEMS@91061|Bacilli,1ZMEV@1386|Bacillus	91061|Bacilli	C	Iron-sulfur cluster-binding domain	ydeM3	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_3369754_11	909663.KI867149_gene3179	5.692e-35	135.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,42PD2@68525|delta/epsilon subdivisions,2WJIK@28221|Deltaproteobacteria,2MR97@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SEC-C,SPASM
HKD1_k127_3369754_0	909663.KI867150_gene786	0.0	1108.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,42T3U@68525|delta/epsilon subdivisions,2WPDH@28221|Deltaproteobacteria,2MRV1@213462|Syntrophobacterales	28221|Deltaproteobacteria	EH	Thiamine pyrophosphate enzyme, central domain	-	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_3401464_4	1283299.AUKG01000001_gene1326	8.089e-16	83.0	COG4243@1|root,COG4243@2|Bacteria,2HGRK@201174|Actinobacteria,4CSQE@84995|Rubrobacteria	84995|Rubrobacteria	S	VKc	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
HKD1_k127_3401464_1	439235.Dalk_3407	4.803e-152	490.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,42MKR@68525|delta/epsilon subdivisions,2WJ0U@28221|Deltaproteobacteria,2MI24@213118|Desulfobacterales	28221|Deltaproteobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_3401464_0	1120973.AQXL01000119_gene596	1.737e-191	608.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,4H9WR@91061|Bacilli,278X6@186823|Alicyclobacillaceae	91061|Bacilli	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_3401464_5	1131813.AQVT01000001_gene3535	2.638e-15	81.0	COG0346@1|root,COG0346@2|Bacteria,1RB65@1224|Proteobacteria,2U7DP@28211|Alphaproteobacteria,1JV5P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD1_k127_3401464_2	134676.ACPL_8102	6.209e-71	253.0	COG0177@1|root,COG0177@2|Bacteria,2GJ01@201174|Actinobacteria,4DB84@85008|Micromonosporales	201174|Actinobacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0030312,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_3401464_3	207559.Dde_0128	2.636e-60	228.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,4322X@68525|delta/epsilon subdivisions,2WWUP@28221|Deltaproteobacteria,2MDT9@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HKD1_k127_3410016_0	485913.Krac_3419	3.34e-83	293.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,Dimer_Tnp_Tn5,Tnp_DNA_bind
HKD1_k127_3422984_1	335543.Sfum_1457	1.093e-115	380.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MR4N@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Protein export membrane protein	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_3422984_3	335543.Sfum_1458	4.873e-90	315.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MR8F@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_3422984_5	472759.Nhal_2908	3.526e-28	117.0	COG0392@1|root,COG0392@2|Bacteria,1RCBH@1224|Proteobacteria,1S366@1236|Gammaproteobacteria,1X1IF@135613|Chromatiales	135613|Chromatiales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD1_k127_3422984_6	626418.bglu_2g13440	8.919e-12	76.0	COG0392@1|root,COG0392@2|Bacteria,1MWRY@1224|Proteobacteria,2W1IU@28216|Betaproteobacteria,1JZTT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD1_k127_3422984_0	1380394.JADL01000001_gene2976	3.951e-125	407.0	COG1082@1|root,COG1082@2|Bacteria,1R8NU@1224|Proteobacteria,2VDZU@28211|Alphaproteobacteria,2JUZV@204441|Rhodospirillales	204441|Rhodospirillales	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_3422984_2	880073.Calab_1821	2.706e-102	349.0	COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_3422984_4	1313172.YM304_08620	2.506e-54	203.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.303,1.1.1.4	ko:K00004	ko00650,map00650	-	R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3422984_7	1411123.JQNH01000001_gene491	1.952e-06	55.0	COG1028@1|root,COG1028@2|Bacteria,1MVT2@1224|Proteobacteria,2TQKU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fixR	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_3422984_8	1122915.AUGY01000010_gene4522	8.012e-06	50.0	COG1028@1|root,COG1028@2|Bacteria,1UWP2@1239|Firmicutes,4IBZ6@91061|Bacilli,271QR@186822|Paenibacillaceae	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_342712_20	344747.PM8797T_26360	5.586e-11	67.0	COG0268@1|root,COG0268@2|Bacteria,2J0PM@203682|Planctomycetes	203682|Planctomycetes	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD1_k127_342712_5	1499967.BAYZ01000167_gene6737	2.812e-110	377.0	COG0728@1|root,COG0728@2|Bacteria,2NNX8@2323|unclassified Bacteria	2|Bacteria	U	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD1_k127_342712_0	671143.DAMO_1361	1.427e-278	867.0	COG0028@1|root,COG0028@2|Bacteria,2NNMW@2323|unclassified Bacteria	2|Bacteria	EH	thiamine pyrophosphate protein TPP binding domain protein	ilvI	GO:0000287,GO:0003674,GO:0003824,GO:0003984,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0019842,GO:0030976,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1901681	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1907,iB21_1397.B21_00078,iBWG_1329.BWG_0073,iECBD_1354.ECBD_3539,iECB_1328.ECB_00079,iECD_1391.ECD_00079,iUTI89_1310.UTI89_C0085,iYL1228.KPN_00082	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_342712_12	671143.DAMO_1362	8.91e-60	211.0	COG0440@1|root,COG0440@2|Bacteria,2NPPK@2323|unclassified Bacteria	2|Bacteria	E	ACT domain	ilvH	GO:0003674,GO:0003824,GO:0003984,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005948,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016053,GO:0016740,GO:0016744,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494,GO:1990234	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1906,iECNA114_1301.ECNA114_0072,iEcSMS35_1347.EcSMS35_0084,iG2583_1286.G2583_0082,iSFxv_1172.SFxv_0077,iUTI89_1310.UTI89_C0086	ACT,ACT_5,ALS_ss_C
HKD1_k127_342712_2	671143.DAMO_1363	6.245e-170	541.0	COG0059@1|root,COG0059@2|Bacteria,2NNKS@2323|unclassified Bacteria	2|Bacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004455,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006573,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009097,GO:0009099,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0022607,GO:0036094,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iEC042_1314.EC042_4152,iECABU_c1320.ECABU_c42560,iECED1_1282.ECED1_4460,iECO103_1326.ECO103_4390,iECO111_1330.ECO111_4600,iECO26_1355.ECO26_4812,iECP_1309.ECP_3967,iECSE_1348.ECSE_4057,iECUMN_1333.ECUMN_4300,iEcE24377_1341.EcE24377A_4285,iEcSMS35_1347.EcSMS35_4140,iHN637.CLJU_RS07505,iHN637.CLJU_RS10005,iHN637.CLJU_RS10010,iIT341.HP0330,iJN746.PP_4678,iLF82_1304.LF82_1103,iLJ478.TM0550	IlvC,IlvN
HKD1_k127_342712_23	279714.FuraDRAFT_1830	0.000308	49.0	COG4969@1|root,COG4969@2|Bacteria,1PJJ0@1224|Proteobacteria,2WA9E@28216|Betaproteobacteria,2KSAY@206351|Neisseriales	206351|Neisseriales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
HKD1_k127_342712_11	671143.DAMO_1366	2.074e-70	250.0	COG0324@1|root,COG0324@2|Bacteria,2NP6D@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016765,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0052381,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD1_k127_342712_3	696281.Desru_2953	2.977e-127	435.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,2603K@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_342712_13	671143.DAMO_1368	3.298e-57	209.0	COG0283@1|root,COG0283@2|Bacteria,2NPCE@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.19,2.7.4.25	ko:K00800,ko:K00945,ko:K03977	ko00240,ko00400,ko01100,ko01110,ko01130,ko01230,map00240,map00400,map01100,map01110,map01130,map01230	M00022,M00052	R00158,R00512,R01665,R03460	RC00002,RC00350	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	Cytidylate_kin
HKD1_k127_342712_1	671143.DAMO_1370	4.378e-272	850.0	COG0539@1|root,COG1185@1|root,COG0539@2|Bacteria,COG1185@2|Bacteria,2NNTP@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein S1	rpsA	-	1.17.7.4	ko:K02945,ko:K03527,ko:K07571	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	S1
HKD1_k127_342712_16	671143.DAMO_1373	4.086e-37	141.0	COG0776@1|root,COG0776@2|Bacteria,2NPU6@2323|unclassified Bacteria	2|Bacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	ihfB	-	-	ko:K03530,ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_342712_18	1499967.BAYZ01000069_gene1879	1.363e-34	152.0	COG2114@1|root,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HKD1_k127_342712_14	246969.TAM4_658	2.837e-54	196.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci	183968|Thermococci	F	Hit family	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HKD1_k127_342712_8	671143.DAMO_1375	5.979e-86	286.0	COG1259@1|root,COG1259@2|Bacteria,2NP7X@2323|unclassified Bacteria	2|Bacteria	S	Bifunctional nuclease	-	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0016020,GO:0030312,GO:0044464,GO:0071944	-	ko:K03617,ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
HKD1_k127_342712_6	1219084.AP014508_gene184	2.757e-109	363.0	COG1052@1|root,COG1052@2|Bacteria,2GC25@200918|Thermotogae	200918|Thermotogae	C	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_342712_9	671143.DAMO_1516	8.322e-81	289.0	COG0430@1|root,COG0430@2|Bacteria,2NP9K@2323|unclassified Bacteria	2|Bacteria	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0009975,GO:0016874,GO:0016886,GO:0044424,GO:0044464,GO:0140098	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
HKD1_k127_342712_15	941449.dsx2_0916	1.545e-44	181.0	COG1246@1|root,COG1246@2|Bacteria,1RHT7@1224|Proteobacteria,42SGE@68525|delta/epsilon subdivisions,2WP91@28221|Deltaproteobacteria,2MBN6@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM GCN5-related N-acetyltransferase	argA	-	2.3.1.1	ko:K00619	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0946	Acetyltransf_1,Acetyltransf_7
HKD1_k127_342712_4	1121422.AUMW01000010_gene1087	2.048e-124	421.0	COG1283@1|root,COG1283@2|Bacteria,1TP4K@1239|Firmicutes,247KT@186801|Clostridia,25ZXV@186807|Peptococcaceae	186801|Clostridia	P	PFAM Na Picotransporter	-	-	-	ko:K03324	-	-	-	-	ko00000,ko02000	2.A.58.2	-	-	Na_Pi_cotrans,PhoU
HKD1_k127_342712_10	671143.DAMO_1514	6.04e-72	273.0	COG1806@1|root,COG1806@2|Bacteria,2NRN6@2323|unclassified Bacteria	2|Bacteria	S	Kinase/pyrophosphorylase	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD1_k127_342712_19	671143.DAMO_0856	1.215e-13	82.0	COG1522@1|root,COG1522@2|Bacteria	671143.DAMO_0856|-	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_342712_7	760568.Desku_1221	2.408e-86	297.0	COG1085@1|root,COG1085@2|Bacteria,1TS3F@1239|Firmicutes,249P3@186801|Clostridia,2602F@186807|Peptococcaceae	186801|Clostridia	H	Galactose-1-phosphate uridyl transferase, C-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,DUF4931,GalP_UDP_tr_C,GalP_UDP_transf
HKD1_k127_342712_17	269799.Gmet_3548	3.907e-35	145.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,42RP3@68525|delta/epsilon subdivisions,2WNPA@28221|Deltaproteobacteria,43T4C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD1_k127_3454260_2	251221.35213026	4.146e-09	64.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Kelch_1,Kelch_6
HKD1_k127_3454260_0	1396418.BATQ01000103_gene5522	7.031e-59	223.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD1_k127_3454260_1	1137269.AZWL01000001_gene5304	4.809e-13	71.0	COG3964@1|root,COG3964@2|Bacteria,2IERE@201174|Actinobacteria	201174|Actinobacteria	S	Amidohydrolase family	dho	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_3456094_0	1411123.JQNH01000001_gene2791	1.948e-136	449.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	COG1593 TRAP-type C4-dicarboxylate transport system large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_3456094_3	1411123.JQNH01000001_gene2790	3.64e-15	82.0	COG3090@1|root,COG3090@2|Bacteria,1N312@1224|Proteobacteria,2UCEB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_3456094_1	1178482.BJB45_03540	1.023e-115	383.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria	1224|Proteobacteria	G	TRAP-type C4-dicarboxylate transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_3456094_2	1122947.FR7_1153	2.185e-89	301.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,4H2N6@909932|Negativicutes	1239|Firmicutes	G	Transketolase, pyridine binding domain protein	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_3458691_1	324602.Caur_2628	3.542e-95	316.0	COG0412@1|root,COG0412@2|Bacteria,2G8NW@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD1_k127_3458691_2	700598.Niako_2991	3.407e-44	165.0	COG3832@1|root,COG3832@2|Bacteria,4NUFM@976|Bacteroidetes,1IY2B@117747|Sphingobacteriia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_3458691_0	861299.J421_6182	2.312e-146	469.0	COG1819@1|root,COG1819@2|Bacteria,1ZV4F@142182|Gemmatimonadetes	142182|Gemmatimonadetes	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	2.4.1.310	ko:K16444	ko01055,map01055	-	-	-	ko00000,ko00001,ko01000	-	GT1	-	Glyco_transf_28,UDPGT
HKD1_k127_3477181_1	886293.Sinac_7148	2.33e-52	190.0	COG3385@1|root,COG3385@2|Bacteria,2IZE5@203682|Planctomycetes	203682|Planctomycetes	L	COG5659 FOG Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_3477181_0	765911.Thivi_2047	2.337e-92	319.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1WWWX@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_3485928_4	251221.35214712	1.433e-51	193.0	COG0612@1|root,COG0612@2|Bacteria,1G3GH@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_3485928_5	479434.Sthe_2978	1.763e-23	105.0	COG0735@1|root,COG0735@2|Bacteria,2G74Y@200795|Chloroflexi,27YIH@189775|Thermomicrobia	189775|Thermomicrobia	P	Ferric uptake regulator family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_3485928_3	562970.Btus_2410	4.671e-63	229.0	COG0803@1|root,COG0803@2|Bacteria,1TPG7@1239|Firmicutes,4H9UN@91061|Bacilli,278FS@186823|Alicyclobacillaceae	91061|Bacilli	P	Belongs to the bacterial solute-binding protein 9 family	adcA	-	-	ko:K09815,ko:K09818	ko02010,map02010	M00242,M00243	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ZinT,ZnuA
HKD1_k127_3485928_2	266117.Rxyl_1142	1.138e-75	263.0	COG1121@1|root,COG1121@2|Bacteria,2GN95@201174|Actinobacteria,4CRK4@84995|Rubrobacteria	84995|Rubrobacteria	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K09820	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
HKD1_k127_3485928_1	479434.Sthe_2975	1.001e-79	274.0	COG1108@1|root,COG1108@2|Bacteria,2G6GH@200795|Chloroflexi,27XKB@189775|Thermomicrobia	189775|Thermomicrobia	P	ABC 3 transport family	-	-	-	ko:K09819	-	M00243	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HKD1_k127_3485928_0	1037409.BJ6T_56700	1.829e-139	468.0	COG4134@1|root,COG4134@2|Bacteria,1N6GY@1224|Proteobacteria,2U0KB@28211|Alphaproteobacteria,3K21E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD1_k127_349436_1	1128421.JAGA01000002_gene1004	5.317e-70	244.0	COG0122@1|root,COG0122@2|Bacteria,2NRER@2323|unclassified Bacteria	2|Bacteria	G	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_349436_3	497964.CfE428DRAFT_1724	1.108e-13	72.0	COG1028@1|root,COG1028@2|Bacteria,46SM0@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD1_k127_349436_2	98439.AJLL01000098_gene1975	6.856e-30	123.0	COG0071@1|root,COG0071@2|Bacteria,1G5ZC@1117|Cyanobacteria	1117|Cyanobacteria	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_349436_0	1173021.ALWA01000020_gene235	8.286e-128	420.0	COG0466@1|root,COG0466@2|Bacteria,1G3NF@1117|Cyanobacteria	1117|Cyanobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	-	-	-	-	-	-	-	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_350449_0	272134.KB731325_gene580	1.647e-240	773.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria,1H837@1150|Oscillatoriales	1117|Cyanobacteria	Q	Non-ribosomal peptide synthetase modules and related	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,Methyltransf_12,PP-binding,PilZ
HKD1_k127_350449_1	452637.Oter_1973	7.626e-219	709.0	COG1020@1|root,COG2230@1|root,COG3319@1|root,COG1020@2|Bacteria,COG2230@2|Bacteria,COG3319@2|Bacteria	2|Bacteria	Q	amino acid activation for nonribosomal peptide biosynthetic process	dhbF	-	2.1.1.79,6.3.2.14	ko:K00574,ko:K02364,ko:K04780,ko:K19103	ko00261,ko01053,ko01110,ko01130,map00261,map01053,map01110,map01130	M00736	R07644,R10880	RC00064,RC00141,RC00162,RC03046,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002,ko01000,ko01008	-	-	-	AMP-binding,AMP-binding_C,Bac_luciferase,Condensation,Formyl_trans_C,Formyl_trans_N,Methyltransf_23,Methyltransf_25,Methyltransf_32,PP-binding,Thioesterase
HKD1_k127_350449_2	1336208.JADY01000009_gene2535	6.447e-213	679.0	COG1061@1|root,COG1061@2|Bacteria,1Q7YV@1224|Proteobacteria,2U3NE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KL	PFAM type III restriction protein res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ResIII
HKD1_k127_350449_9	172088.AUGA01000003_gene5565	2.465e-06	49.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TR15@28211|Alphaproteobacteria,3JSF6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	MA20_40160	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_350449_5	497964.CfE428DRAFT_0562	1.787e-51	196.0	COG0457@1|root,COG0457@2|Bacteria	497964.CfE428DRAFT_0562|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_350449_3	322710.Avin_46290	7.086e-107	358.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,1RVJU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	phaC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_350449_7	472759.Nhal_1889	1.854e-13	73.0	COG0778@1|root,COG0778@2|Bacteria,1RJMP@1224|Proteobacteria,1T0ZH@1236|Gammaproteobacteria,1X0TI@135613|Chromatiales	135613|Chromatiales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_350449_10	557599.MKAN_15275	2.568e-05	49.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_350449_6	107636.JQNK01000011_gene1	5.473e-29	120.0	COG5527@1|root,COG5527@2|Bacteria,1QBGA@1224|Proteobacteria,2TUPV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Protein involved in initiation of plasmid replication	-	-	-	-	-	-	-	-	-	-	-	-	Rep_3
HKD1_k127_350449_4	1111479.AXAR01000012_gene1419	6.306e-105	361.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,4HDD6@91061|Bacilli	91061|Bacilli	Q	Multicopper	cotA	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD1_k127_350449_8	1122951.ATUE01000006_gene1469	3.628e-10	68.0	2DE7G@1|root,2ZKUC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_350812_3	1379698.RBG1_1C00001G1060	1.481e-122	400.0	COG1009@1|root,COG1009@2|Bacteria,2NNU6@2323|unclassified Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD1_k127_350812_13	671143.DAMO_2693	6.226e-38	144.0	COG0713@1|root,COG0713@2|Bacteria,2NPU2@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0072521,GO:0098796,GO:0098797,GO:0098803,GO:1901135,GO:1901360,GO:1901564,GO:1902494,GO:1990204	1.6.5.3	ko:K00340,ko:K05576	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_350812_14	671143.DAMO_2694	8.956e-32	130.0	COG0839@1|root,COG0839@2|Bacteria,2NPUC@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_350812_6	1304888.ATWF01000001_gene2085	3.481e-108	360.0	COG1005@1|root,COG1005@2|Bacteria,2GF42@200930|Deferribacteres	200930|Deferribacteres	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_350812_2	671143.DAMO_1616	3.665e-180	579.0	COG1034@1|root,COG1034@2|Bacteria	2|Bacteria	C	ATP synthesis coupled electron transport	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HKD1_k127_350812_0	671143.DAMO_2696	9.574e-215	673.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_350812_10	448385.sce4224	2.257e-44	166.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42SRI@68525|delta/epsilon subdivisions,2WQ7W@28221|Deltaproteobacteria,2Z370@29|Myxococcales	28221|Deltaproteobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_350812_1	671143.DAMO_2698	1.108e-191	605.0	COG0649@1|root,COG0649@2|Bacteria,2NNWG@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_350812_8	671143.DAMO_2699	9.656e-67	231.0	COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD1_k127_350812_11	671143.DAMO_2700	5.234e-42	159.0	COG0838@1|root,COG0838@2|Bacteria,2NPTW@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0030964,GO:0032991,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044425,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0098796,GO:1901135,GO:1901360,GO:1901564,GO:1902494	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_350812_15	671143.DAMO_2701	5.024e-21	99.0	COG0636@1|root,COG0636@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	atpE	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_350812_7	671143.DAMO_2702	3.671e-96	322.0	COG0356@1|root,COG0356@2|Bacteria,2NPRQ@2323|unclassified Bacteria	2|Bacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016021,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0031224,GO:0031226,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0042777,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045263,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_350812_16	671143.DAMO_2703	1.592e-15	79.0	COG5336@1|root,COG5336@2|Bacteria,2NRT4@2323|unclassified Bacteria	2|Bacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HKD1_k127_350812_4	1173264.KI913949_gene3058	2.732e-120	393.0	COG1171@1|root,COG1171@2|Bacteria,1GC6F@1117|Cyanobacteria,1HE54@1150|Oscillatoriales	1117|Cyanobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HKD1_k127_350812_12	313612.L8106_28786	1.674e-41	163.0	COG2755@1|root,COG2755@2|Bacteria,1G8DF@1117|Cyanobacteria,1HFNB@1150|Oscillatoriales	1117|Cyanobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_350812_5	671143.DAMO_2815	4.854e-112	376.0	COG0488@1|root,COG0488@2|Bacteria,2NNPH@2323|unclassified Bacteria	2|Bacteria	S	ABC transporter	MA20_28645	-	3.6.3.29,3.6.3.41	ko:K06022,ko:K06158,ko:K10834	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_3517253_19	485913.Krac_11812	1.228e-65	229.0	COG0624@1|root,COG4992@1|root,COG0624@2|Bacteria,COG4992@2|Bacteria,2G5SG@200795|Chloroflexi	200795|Chloroflexi	E	Catalyzes the transfer of the amino group of L-glutamate to LysW -aminoadipate 6-semialdehyde, generating LysW -gamma-L- lysine	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3,Peptidase_M20
HKD1_k127_3517253_12	324602.Caur_1204	8.697e-102	344.0	COG0624@1|root,COG0624@2|Bacteria,2G61X@200795|Chloroflexi,3758J@32061|Chloroflexia	32061|Chloroflexia	E	Catalyzes the release of L-lysine from LysW -gamma-L- lysine	lysK	-	-	ko:K05831	ko00220,ko00300,ko01100,ko01210,ko01230,map00220,map00300,map01100,map01210,map01230	M00031,M00763	R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002	-	-	-	Peptidase_M20
HKD1_k127_3517253_34	1064535.MELS_0167	9.054e-13	71.0	COG1055@1|root,COG1055@2|Bacteria,1TT1V@1239|Firmicutes,4H35Q@909932|Negativicutes	909932|Negativicutes	P	COG1055 Na H antiporter NhaD and related arsenite permeases	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
HKD1_k127_3517253_31	671143.DAMO_2684	3.878e-16	81.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	mauD	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HKD1_k127_3517253_36	1540221.JQNI01000004_gene82	2.256e-08	58.0	COG0526@1|root,COG0526@2|Bacteria,1WJ2P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CO	periplasmic protein thiol disulfide oxidoreductases, DsbE subfamily	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HKD1_k127_3517253_15	1382306.JNIM01000001_gene1471	7.799e-73	264.0	COG0589@1|root,COG0589@2|Bacteria,2G8FB@200795|Chloroflexi	200795|Chloroflexi	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3517253_3	1121918.ARWE01000001_gene3102	6.592e-188	596.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42PNI@68525|delta/epsilon subdivisions,2WJNF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp,Usp
HKD1_k127_3517253_22	1379270.AUXF01000004_gene3184	5.67e-51	185.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	ATC_hydrolase,SWIM
HKD1_k127_3517253_23	1195236.CTER_4749	1.494e-46	175.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,3WIF0@541000|Ruminococcaceae	186801|Clostridia	S	Flavin reductase-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_3517253_24	671143.DAMO_2897	9.527e-42	161.0	COG5663@1|root,COG5663@2|Bacteria	2|Bacteria	S	phosphatase activity	yqfW	-	-	ko:K05967	-	-	-	-	ko00000	-	-	-	NT5C
HKD1_k127_3517253_26	1379270.AUXF01000001_gene2567	1.612e-33	136.0	COG1309@1|root,COG1309@2|Bacteria,1ZV9M@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Bacterial transcriptional repressor C-terminal	-	-	-	ko:K16137	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_13,TetR_N
HKD1_k127_3517253_10	671143.DAMO_3156	8.52e-121	407.0	COG1538@1|root,COG1538@2|Bacteria,2NP5D@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	tolC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_3517253_16	329726.AM1_0403	1.937e-68	238.0	COG1898@1|root,COG1898@2|Bacteria,1G0QA@1117|Cyanobacteria	1117|Cyanobacteria	G	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	rfbC	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HKD1_k127_3517253_13	309801.trd_A0475	4.282e-97	326.0	COG0179@1|root,COG0179@2|Bacteria,2G6HH@200795|Chloroflexi,27Z1N@189775|Thermomicrobia	189775|Thermomicrobia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_3517253_9	1121920.AUAU01000012_gene2648	2.096e-140	464.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_3517253_14	1121920.AUAU01000012_gene2649	6.398e-86	292.0	COG0437@1|root,COG0437@2|Bacteria,3Y5RE@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HKD1_k127_3517253_32	768670.Calni_0644	1.293e-13	75.0	2DRRJ@1|root,33CRQ@2|Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_3517253_29	1232437.KL662048_gene5081	1.152e-24	112.0	COG0509@1|root,COG0509@2|Bacteria,1NRFW@1224|Proteobacteria,42ZAN@68525|delta/epsilon subdivisions,2WUQI@28221|Deltaproteobacteria,2MMY2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
HKD1_k127_3517253_5	404589.Anae109_1798	8.035e-178	571.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKFQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3517253_25	404589.Anae109_1797	2.645e-40	155.0	COG1913@1|root,COG1913@2|Bacteria,1NEU5@1224|Proteobacteria,42WCP@68525|delta/epsilon subdivisions,2X5BA@28221|Deltaproteobacteria,2Z2ND@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
HKD1_k127_3517253_7	290397.Adeh_2011	2.539e-145	477.0	COG2770@1|root,COG4191@1|root,COG2770@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42P9E@68525|delta/epsilon subdivisions,2WMH3@28221|Deltaproteobacteria,2Z0GM@29|Myxococcales	28221|Deltaproteobacteria	T	HAMP domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD1_k127_3517253_8	479434.Sthe_0907	4.008e-142	465.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,27XWA@189775|Thermomicrobia	189775|Thermomicrobia	J	Belongs to the amidase family	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_3517253_0	671143.DAMO_2884	0.0	1077.0	COG0296@1|root,COG0296@2|Bacteria	2|Bacteria	G	1,4-alpha-glucan branching enzyme activity	glgB	GO:0000271,GO:0003674,GO:0003824,GO:0003844,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0055114,GO:0071704,GO:1901576	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_3517253_27	330214.NIDE4047	9.888e-31	123.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_3517253_11	1205680.CAKO01000007_gene4329	7.287e-104	346.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,2JQ2Q@204441|Rhodospirillales	204441|Rhodospirillales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_3517253_4	1123242.JH636434_gene3236	3.27e-187	598.0	COG5476@1|root,COG5476@2|Bacteria,2J2WQ@203682|Planctomycetes	203682|Planctomycetes	S	MlrC C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	DUF1485,MlrC_C
HKD1_k127_3517253_20	326427.Cagg_0516	2.455e-58	211.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HKD1_k127_3517253_1	485915.Dret_1750	7.624e-265	844.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
HKD1_k127_3517253_37	335543.Sfum_1944	3.728e-06	54.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_3517253_21	237368.SCABRO_02647	9.949e-53	196.0	COG1213@1|root,COG1213@2|Bacteria	2|Bacteria	M	nucleotidyl transferase	-	-	2.7.7.74	ko:K07281	ko00562,map00562	-	R09669	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,NTP_transferase
HKD1_k127_3517253_2	671143.DAMO_2682	2.909e-240	752.0	COG0043@1|root,COG0043@2|Bacteria,2NPAD@2323|unclassified Bacteria	2|Bacteria	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008694,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	iECO111_1330.ECO111_4669,iIT341.HP0396	UbiD
HKD1_k127_3517253_18	688269.Theth_0549	1.966e-67	241.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	MA20_03535	-	1.1.1.399,1.1.1.95	ko:K00058,ko:K04496	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,ko04310,ko04330,ko05200,ko05220,map00260,map00680,map01100,map01120,map01130,map01200,map01230,map04310,map04330,map05200,map05220	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3517253_6	1429916.X566_17395	3.126e-176	569.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_3517253_38	408672.NBCG_04475	8.37e-06	55.0	2CJ0Q@1|root,32UT5@2|Bacteria,2IH8Y@201174|Actinobacteria,4DV1S@85009|Propionibacteriales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_3517253_17	365046.Rta_27110	2.159e-68	244.0	COG3181@1|root,COG3181@2|Bacteria,1R6C7@1224|Proteobacteria,2VK24@28216|Betaproteobacteria,4ACTF@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_3517253_30	797114.C475_21899	1.286e-22	103.0	COG1661@1|root,arCOG04212@2157|Archaea,2XWU3@28890|Euryarchaeota,23V52@183963|Halobacteria	183963|Halobacteria	S	DNA-binding protein with PD1-like DNA-binding motif	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
HKD1_k127_3517253_28	203119.Cthe_1854	7.638e-27	115.0	COG3695@1|root,COG3695@2|Bacteria,1UIU9@1239|Firmicutes,25ES2@186801|Clostridia,3WJSV@541000|Ruminococcaceae	186801|Clostridia	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	ko:K07443	-	-	-	-	ko00000	-	-	-	DNA_binding_1
HKD1_k127_3528209_3	395493.BegalDRAFT_0707	1.135e-26	119.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	ko:K17292	-	-	-	-	ko00000,ko04147,ko04812	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,Hpt,Reg_prop,Response_reg,Y_Y_Y,dCache_1
HKD1_k127_3528209_4	439235.Dalk_4490	3.043e-23	106.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42M4Q@68525|delta/epsilon subdivisions,2X5DU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0069	GGDEF,Response_reg
HKD1_k127_3528209_0	1380355.JNIJ01000074_gene5450	4.086e-66	231.0	COG1434@1|root,COG1434@2|Bacteria,1NUEZ@1224|Proteobacteria,2URDY@28211|Alphaproteobacteria,3K3W0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Gram-negative-bacterium-type cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3528209_2	1125863.JAFN01000001_gene284	6.891e-35	147.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,42R0Q@68525|delta/epsilon subdivisions,2WN87@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Beta-propeller domains of methanol dehydrogenase type	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_3528209_1	1123276.KB893245_gene1260	4.345e-38	155.0	COG3762@1|root,COG3762@2|Bacteria,4NQIT@976|Bacteroidetes,47QCD@768503|Cytophagia	976|Bacteroidetes	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
HKD1_k127_3529456_6	204669.Acid345_1618	3.095e-39	150.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_3529456_2	204669.Acid345_1619	5.514e-120	398.0	COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria,2JMXU@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_3529456_3	204669.Acid345_1620	2.171e-115	377.0	COG1136@1|root,COG1136@2|Bacteria,3Y4A6@57723|Acidobacteria,2JMVQ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3529456_1	204669.Acid345_1621	1.1e-126	418.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria,2JMYN@204432|Acidobacteriia	204432|Acidobacteriia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_3529456_4	1300345.LF41_901	1.188e-109	382.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_3529456_5	247490.KSU1_D0176	5.534e-105	354.0	COG1943@1|root,COG1943@2|Bacteria,2IYXS@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_3529456_0	316067.Geob_0018	0.0	1104.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	norZ	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD1_k127_3529456_7	1185876.BN8_04099	1.83e-13	77.0	COG1917@1|root,COG1917@2|Bacteria,4NEZV@976|Bacteroidetes,47XRW@768503|Cytophagia	976|Bacteroidetes	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_3529456_8	1254432.SCE1572_20060	1.19e-10	63.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2X7TS@28221|Deltaproteobacteria,2YXZZ@29|Myxococcales	28221|Deltaproteobacteria	K	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	ko:K12266	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,HTH_8,Sigma54_activat
HKD1_k127_3529832_0	903818.KI912268_gene2536	4.091e-282	889.0	COG1061@1|root,COG4951@1|root,COG1061@2|Bacteria,COG4951@2|Bacteria,3Y66N@57723|Acidobacteria	57723|Acidobacteria	L	Type III restriction enzyme res subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3529832_5	882378.RBRH_00337	2.14e-18	87.0	COG4226@1|root,COG4226@2|Bacteria,1MZYR@1224|Proteobacteria,2VUYG@28216|Betaproteobacteria,1KHJU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
HKD1_k127_3529832_3	882378.RBRH_00337	1.356e-38	151.0	COG4226@1|root,COG4226@2|Bacteria,1MZYR@1224|Proteobacteria,2VUYG@28216|Betaproteobacteria,1KHJU@119060|Burkholderiaceae	28216|Betaproteobacteria	S	HicB family	-	-	-	-	-	-	-	-	-	-	-	-	HicB
HKD1_k127_3529832_1	479434.Sthe_2999	7.664e-130	428.0	COG1804@1|root,COG1804@2|Bacteria,2GB4P@200795|Chloroflexi,27XYZ@189775|Thermomicrobia	2|Bacteria	C	L-carnitine dehydratase bile acid-inducible protein F	MA20_43260	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD1_k127_3529832_2	272563.CD630_07970	6.8e-79	274.0	COG0119@1|root,COG0119@2|Bacteria,1TQG3@1239|Firmicutes,24AUV@186801|Clostridia	186801|Clostridia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_3529832_4	744979.R2A130_2918	1.943e-30	130.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,2TRM3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD1_k127_3555642_2	1144275.COCOR_01383	9.319e-15	84.0	2ENGF@1|root,33G3Y@2|Bacteria,1P8WT@1224|Proteobacteria,43261@68525|delta/epsilon subdivisions,2WXJG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3555642_0	999411.HMPREF1092_00975	1.709e-60	239.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_3555642_1	56780.SYN_02956	4.001e-53	193.0	COG2202@1|root,COG2203@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	GAF,HTH_8,PAS,PAS_3,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_3555889_0	1267533.KB906733_gene3215	1.771e-32	134.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_3562319_4	1111479.AXAR01000003_gene1549	8.108e-11	62.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,4HA9Z@91061|Bacilli,279HI@186823|Alicyclobacillaceae	91061|Bacilli	C	Zinc-binding dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3562319_3	768671.ThimaDRAFT_0870	2.074e-57	207.0	COG3009@1|root,COG3009@2|Bacteria,1N9IG@1224|Proteobacteria,1SCIM@1236|Gammaproteobacteria,1X1Z1@135613|Chromatiales	135613|Chromatiales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_aux
HKD1_k127_3562319_2	768671.ThimaDRAFT_0869	6.442e-102	342.0	COG1463@1|root,COG1463@2|Bacteria,1MYEF@1224|Proteobacteria,1S8EQ@1236|Gammaproteobacteria,1WYKW@135613|Chromatiales	135613|Chromatiales	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
HKD1_k127_3562319_1	768671.ThimaDRAFT_0868	1.406e-111	365.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S1PR@1236|Gammaproteobacteria,1WY6G@135613|Chromatiales	135613|Chromatiales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_3562319_0	768671.ThimaDRAFT_0867	6.487e-127	417.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1S0WJ@1236|Gammaproteobacteria,1WWFB@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
HKD1_k127_3562620_8	316057.RPD_0048	4.806e-85	298.0	COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria,3JVI6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Periplasmic binding protein	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3562620_11	909663.KI867150_gene1229	1.635e-33	138.0	COG1802@1|root,COG1802@2|Bacteria,1MWG2@1224|Proteobacteria,42P4Y@68525|delta/epsilon subdivisions,2WM8E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_3562620_12	1449126.JQKL01000016_gene2856	7.879e-13	72.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_9
HKD1_k127_3562620_13	760568.Desku_0588	6.939e-05	52.0	2DG31@1|root,2ZU90@2|Bacteria,1W6HY@1239|Firmicutes,25691@186801|Clostridia	186801|Clostridia	S	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_3562620_0	1449126.JQKL01000016_gene2854	4.386e-189	609.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,26A1J@186813|unclassified Clostridiales	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_3562620_6	479434.Sthe_1791	1.306e-93	328.0	COG1024@1|root,COG1024@2|Bacteria,2G5JW@200795|Chloroflexi,27YD9@189775|Thermomicrobia	189775|Thermomicrobia	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_3562620_9	868595.Desca_1124	3.423e-53	198.0	COG0491@1|root,COG0491@2|Bacteria,1TT3D@1239|Firmicutes,24BV1@186801|Clostridia,266FJ@186807|Peptococcaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_3562620_4	1499967.BAYZ01000118_gene3244	4.012e-104	353.0	COG1641@1|root,COG1641@2|Bacteria,2NNX0@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF111	larC	-	4.99.1.12	ko:K06898,ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_3562620_7	1499967.BAYZ01000073_gene2004	1.356e-86	294.0	COG1691@1|root,COG1691@2|Bacteria,2NPQT@2323|unclassified Bacteria	2|Bacteria	S	AIR carboxylase	cpmA	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD1_k127_3562620_2	909663.KI867151_gene3148	9.863e-114	374.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,42N9N@68525|delta/epsilon subdivisions,2WIY9@28221|Deltaproteobacteria,2MQ6C@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	ATP phosphoribosyltransferase	hisG	GO:0000105,GO:0003674,GO:0003824,GO:0003879,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD1_k127_3562620_3	383372.Rcas_0019	3.054e-111	374.0	COG0624@1|root,COG0624@2|Bacteria,2G8FI@200795|Chloroflexi,376ZQ@32061|Chloroflexia	32061|Chloroflexia	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3562620_5	285535.JOEY01000112_gene2157	1.014e-95	324.0	COG0111@1|root,COG0111@2|Bacteria,2IEY1@201174|Actinobacteria	201174|Actinobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3562620_1	1009370.ALO_05073	4.124e-117	382.0	COG4336@1|root,COG4336@2|Bacteria,1TRY8@1239|Firmicutes,4H2W9@909932|Negativicutes	909932|Negativicutes	S	Belongs to the D-glutamate cyclase family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1445
HKD1_k127_3562620_10	1009370.ALO_08138	2.07e-43	164.0	COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes	1239|Firmicutes	E	ABC-type branched-chain amino acid transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3577484_2	1255043.TVNIR_1131	1.52e-06	50.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria,1X044@135613|Chromatiales	135613|Chromatiales	L	PFAM Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	GIIM,RVT_1
HKD1_k127_3577484_0	522306.CAP2UW1_0548	3.38e-179	576.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_3577484_1	443598.AUFA01000086_gene979	1.601e-28	119.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2TVFI@28211|Alphaproteobacteria,3JXIQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DNA invertase Pin	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_3593080_0	1267534.KB906755_gene4600	1.297e-133	440.0	28ITY@1|root,2Z8SS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3593080_1	1218084.BBJK01000037_gene3521	2.886e-100	334.0	COG2866@1|root,COG2866@2|Bacteria,1MZYN@1224|Proteobacteria,2WE6N@28216|Betaproteobacteria,1KBXD@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Zn_pept	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD1_k127_3599270_3	1123242.JH636435_gene2133	1.011e-82	286.0	COG2055@1|root,COG2055@2|Bacteria,2IZK5@203682|Planctomycetes	203682|Planctomycetes	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_3599270_5	251229.Chro_4254	3.439e-47	183.0	COG0500@1|root,COG0500@2|Bacteria,1GR1R@1117|Cyanobacteria	1117|Cyanobacteria	Q	Histone methylation protein DOT1	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_3599270_0	1217718.ALOU01000038_gene3330	1.454e-194	618.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
HKD1_k127_3599270_2	1121440.AUMA01000005_gene2757	1.218e-114	383.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,42RH5@68525|delta/epsilon subdivisions,2X87W@28221|Deltaproteobacteria,2MHCK@213115|Desulfovibrionales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
HKD1_k127_3599270_4	1187851.A33M_1768	2.073e-68	240.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,2U3GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
HKD1_k127_3599270_1	1183438.GKIL_0310	7.199e-121	411.0	COG0433@1|root,COG0561@1|root,COG0433@2|Bacteria,COG0561@2|Bacteria,1G3GC@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DUF87,Hydrolase_3
HKD1_k127_3615071_3	1288079.AUKN01000011_gene1391	3.317e-18	86.0	COG1028@1|root,COG1028@2|Bacteria,2I01P@201174|Actinobacteria	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_3615071_1	1068978.AMETH_3993	2.769e-70	252.0	COG1063@1|root,COG1063@2|Bacteria,2GKBE@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	adh	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3615071_0	1304874.JAFY01000002_gene604	1.526e-72	256.0	COG3181@1|root,COG3181@2|Bacteria,3TB6N@508458|Synergistetes	508458|Synergistetes	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_3615071_4	1122237.AUGQ01000005_gene1428	4.836e-10	67.0	293R6@1|root,31H12@2|Bacteria,2INXY@201174|Actinobacteria	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_3615071_2	484770.UFO1_3469	9.153e-60	213.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,4H2PX@909932|Negativicutes	909932|Negativicutes	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_3682226_7	671143.DAMO_1309	1.941e-09	58.0	COG1943@1|root,COG1943@2|Bacteria,2NRRG@2323|unclassified Bacteria	2|Bacteria	L	Transposase IS200 like	isplu5A	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_3682226_2	525897.Dbac_1408	3.249e-112	372.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42Z2M@68525|delta/epsilon subdivisions,2WTRP@28221|Deltaproteobacteria,2MGVY@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_3682226_1	338963.Pcar_2117	2.051e-218	708.0	COG4231@1|root,COG4231@2|Bacteria,1MUKS@1224|Proteobacteria,42N44@68525|delta/epsilon subdivisions,2WKYE@28221|Deltaproteobacteria,43UAV@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA-2	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
HKD1_k127_3682226_5	338963.Pcar_2116	5.807e-34	141.0	COG1014@1|root,COG1014@2|Bacteria,1N2W3@1224|Proteobacteria,42THX@68525|delta/epsilon subdivisions,2WQ6P@28221|Deltaproteobacteria,43V53@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB-2	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_3682226_3	525897.Dbac_1407	7.167e-100	347.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,42MAQ@68525|delta/epsilon subdivisions,2WKK0@28221|Deltaproteobacteria,2M91J@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_3682226_4	525897.Dbac_1406	2.414e-93	334.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_3682226_0	525897.Dbac_1405	0.0	1038.0	COG0410@1|root,COG1541@1|root,COG0410@2|Bacteria,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,2M8S0@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK-3	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_3682226_6	335543.Sfum_0378	2.345e-17	85.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,42PYP@68525|delta/epsilon subdivisions,2WMA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3689872_1	1173028.ANKO01000127_gene4150	6.856e-20	89.0	COG1972@1|root,COG1972@2|Bacteria,1G3CA@1117|Cyanobacteria,1H7FT@1150|Oscillatoriales	1117|Cyanobacteria	F	PFAM Na dependent nucleoside transporter	-	-	-	ko:K03317	-	-	-	-	ko00000	2.A.41	-	-	Gate,Nucleos_tra2_C,Nucleos_tra2_N
HKD1_k127_3689872_0	1196324.A374_14850	6.683e-21	96.0	COG1898@1|root,COG1898@2|Bacteria,1V4G5@1239|Firmicutes,4HGWJ@91061|Bacilli	91061|Bacilli	M	spore coat	spsL	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HKD1_k127_3726848_14	596152.DesU5LDRAFT_3930	3.625e-07	52.0	COG0640@1|root,COG0640@2|Bacteria,1MZT1@1224|Proteobacteria,42VSP@68525|delta/epsilon subdivisions,2WRGT@28221|Deltaproteobacteria,2MCUX@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	PFAM regulatory protein ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_3726848_1	228410.NE1277	2.988e-233	744.0	28HUW@1|root,2Z81F@2|Bacteria,1Q3QA@1224|Proteobacteria,2VK1A@28216|Betaproteobacteria,371Y7@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3726848_4	1380394.JADL01000001_gene2217	1.035e-135	455.0	COG0747@1|root,COG0747@2|Bacteria,1MU3P@1224|Proteobacteria,2TT4M@28211|Alphaproteobacteria,2JQRE@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_3726848_9	1122214.AQWH01000021_gene3164	1.007e-110	366.0	COG0601@1|root,COG0601@2|Bacteria,1MWXF@1224|Proteobacteria,2TR7C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_3726848_3	266779.Meso_4487	9.354e-136	441.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,2TUWG@28211|Alphaproteobacteria,43R5I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_3726848_6	1380394.JADL01000001_gene2214	6.316e-132	429.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_3726848_5	515635.Dtur_1704	1.793e-135	439.0	COG4608@1|root,COG4608@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	gsiA_8	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_3726848_8	243231.GSU2692	2.576e-114	378.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,42MR6@68525|delta/epsilon subdivisions,2WITP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM TRAP transporter solute receptor, TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD1_k127_3726848_2	243231.GSU2691	6.396e-189	599.0	COG2267@1|root,COG2267@2|Bacteria,1MX2H@1224|Proteobacteria,42MNT@68525|delta/epsilon subdivisions,2WJZS@28221|Deltaproteobacteria,43SWW@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3726848_11	243231.GSU2690	3.375e-97	333.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,42R6I@68525|delta/epsilon subdivisions,2WN1K@28221|Deltaproteobacteria,43T11@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	MlaA lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD1_k127_3726848_7	886379.AEWI01000037_gene2948	1.318e-114	379.0	COG1044@1|root,COG1044@2|Bacteria,4NE5G@976|Bacteroidetes,2FMZE@200643|Bacteroidia,3XIW1@558415|Marinilabiliaceae	976|Bacteroidetes	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD1_k127_3726848_10	1313301.AUGC01000004_gene2374	2.006e-101	336.0	COG1043@1|root,COG1043@2|Bacteria,4NEBA@976|Bacteroidetes	976|Bacteroidetes	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_3726848_0	748280.NH8B_1377	0.0	1287.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2VH5H@28216|Betaproteobacteria,2KQCR@206351|Neisseriales	206351|Neisseriales	C	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HKD1_k127_3726848_12	243231.GSU3292	1.114e-35	142.0	COG0735@1|root,COG0735@2|Bacteria,1N0HW@1224|Proteobacteria,42TU6@68525|delta/epsilon subdivisions,2WPZ1@28221|Deltaproteobacteria,43VCX@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Ferric uptake regulator family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_3726848_13	1192034.CAP_7137	2.706e-26	122.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WJ88@28221|Deltaproteobacteria,2YUPC@29|Myxococcales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	crdA	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3736813_7	380703.AHA_0479	0.0001659	51.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria,1R6J6@1224|Proteobacteria,1RNQ0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	MT	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD1_k127_3736813_6	671143.DAMO_1071	6.599e-39	156.0	COG1434@1|root,COG1434@2|Bacteria	2|Bacteria	S	Gram-negative-bacterium-type cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_3736813_2	1089553.Tph_c24780	3.191e-137	457.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD1_k127_3736813_3	671143.DAMO_2570	2.477e-61	220.0	COG0398@1|root,COG0398@2|Bacteria,2NRVF@2323|unclassified Bacteria	2|Bacteria	S	SNARE associated Golgi protein	yjbF	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_3736813_5	269799.Gmet_0042	2.46e-39	164.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,42SY1@68525|delta/epsilon subdivisions,2WPQ7@28221|Deltaproteobacteria,43V12@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HKD1_k127_3736813_4	1411123.JQNH01000001_gene929	7.711e-61	219.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,2TTVF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.69	ko:K00046	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD1_k127_3736813_0	530564.Psta_4769	2.407e-257	812.0	COG1506@1|root,COG1506@2|Bacteria,2IYBE@203682|Planctomycetes	203682|Planctomycetes	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD1_k127_3736813_1	234267.Acid_2224	4.794e-139	452.0	COG0624@1|root,COG0624@2|Bacteria,3Y7TX@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase family M20/M25/M40	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_374091_2	247490.KSU1_C1389	9.311e-93	316.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
HKD1_k127_374091_0	247490.KSU1_C1392	1.356e-180	581.0	COG1032@1|root,COG1032@2|Bacteria,2IYYP@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_374091_1	247490.KSU1_C1393	7.208e-124	414.0	COG3919@1|root,COG3919@2|Bacteria,2J1IT@203682|Planctomycetes	203682|Planctomycetes	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_374091_3	1121918.ARWE01000001_gene2180	1.151e-66	240.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
HKD1_k127_374091_4	247490.KSU1_C1392	1.037e-50	187.0	COG1032@1|root,COG1032@2|Bacteria,2IYYP@203682|Planctomycetes	203682|Planctomycetes	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_375385_2	1040989.AWZU01000039_gene6136	7.361e-43	173.0	COG4225@1|root,COG4225@2|Bacteria,1NQTS@1224|Proteobacteria,2U2ZS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
HKD1_k127_375385_1	1125973.JNLC01000010_gene1846	5.868e-66	236.0	COG1028@1|root,COG1028@2|Bacteria,1MU2T@1224|Proteobacteria,2TSDG@28211|Alphaproteobacteria,3JWEE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059,ko:K07535	ko00061,ko00333,ko00362,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,ko01220,map00061,map00333,map00362,map00780,map01040,map01100,map01120,map01130,map01212,map01220	M00083,M00540,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R05582,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117,RC00154	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_375385_0	1120792.JAFV01000001_gene3922	2.869e-67	230.0	COG0395@1|root,COG0395@2|Bacteria,1R9EH@1224|Proteobacteria,2U07F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_3755072_4	247490.KSU1_C0338	9.17e-98	354.0	COG0642@1|root,COG2199@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,2J515@203682|Planctomycetes	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_3,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_7,PAS_8,PAS_9,Response_reg
HKD1_k127_3755072_2	575540.Isop_3267	8.054e-140	454.0	COG4225@1|root,COG4225@2|Bacteria,2IY9U@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
HKD1_k127_3755072_1	314230.DSM3645_24395	1.37e-196	621.0	COG0205@1|root,COG0205@2|Bacteria,2IYRQ@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_3755072_0	1191523.MROS_2333	2.122e-237	741.0	COG0362@1|root,COG0362@2|Bacteria	2|Bacteria	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD1_k127_3755072_3	886293.Sinac_1624	1.947e-111	367.0	COG0546@1|root,COG0546@2|Bacteria,2IYT6@203682|Planctomycetes	203682|Planctomycetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD1_k127_3755072_5	1121451.DESAM_23122	2.415e-30	121.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PVS@68525|delta/epsilon subdivisions,2WJ7B@28221|Deltaproteobacteria,2M8BH@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.103,1.1.1.303,1.1.1.4	ko:K00004,ko:K00060	ko00260,ko00650,map00260,map00650	-	R01465,R02855,R02946,R10504	RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_N_assoc,ADH_zinc_N
HKD1_k127_378626_1	316067.Geob_2516	1.898e-52	186.0	COG1064@1|root,COG1064@2|Bacteria,1QYWV@1224|Proteobacteria	1224|Proteobacteria	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_378626_0	1366050.N234_22555	1.62e-253	810.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,2VM6A@28216|Betaproteobacteria,1K3IC@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LuxR family transcriptional regulator	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,GerE
HKD1_k127_3797671_3	314278.NB231_07462	2.335e-71	245.0	COG2230@1|root,COG2230@2|Bacteria,1QY55@1224|Proteobacteria,1RYEN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_3797671_1	314278.NB231_07462	2.772e-86	288.0	COG2230@1|root,COG2230@2|Bacteria,1QY55@1224|Proteobacteria,1RYEN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_3797671_4	756272.Plabr_4030	3.103e-55	197.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_3797671_0	292.DM42_4406	3.02e-139	456.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_3797671_6	56107.Cylst_6156	1.623e-49	188.0	2BK59@1|root,32EIW@2|Bacteria,1GJMC@1117|Cyanobacteria,1HS2C@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3797671_2	1242864.D187_009576	4.606e-74	266.0	COG1181@1|root,COG1181@2|Bacteria,1R4RC@1224|Proteobacteria	1224|Proteobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4,CPSase_L_D2
HKD1_k127_3797671_9	929556.Solca_1759	4.888e-20	95.0	2EM7W@1|root,33EX0@2|Bacteria,4P5SH@976|Bacteroidetes,1J02V@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3797671_8	348824.LPU83_4145	1.28e-29	130.0	2C19F@1|root,32ZRH@2|Bacteria,1NJ8W@1224|Proteobacteria,2V4D2@28211|Alphaproteobacteria,4BFUV@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3797671_5	272134.KB731324_gene5961	1.243e-52	188.0	COG3324@1|root,COG3324@2|Bacteria,1G6S0@1117|Cyanobacteria,1HG10@1150|Oscillatoriales	1117|Cyanobacteria	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_3797671_7	1500301.JQMF01000023_gene5528	4.632e-37	147.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,4BM4C@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
HKD1_k127_3844504_0	1122919.KB905650_gene1648	8.933e-234	754.0	COG2352@1|root,COG2352@2|Bacteria,1TQB6@1239|Firmicutes,4HCAF@91061|Bacilli,26QIW@186822|Paenibacillaceae	91061|Bacilli	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	GO:0003674,GO:0003824,GO:0004611,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008964,GO:0016829,GO:0016830,GO:0016831,GO:0044424,GO:0044444,GO:0044464	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD1_k127_3844504_5	1380394.JADL01000002_gene1315	7.485e-55	197.0	COG1546@1|root,COG1546@2|Bacteria,1RHXH@1224|Proteobacteria,2UACN@28211|Alphaproteobacteria,2JWT0@204441|Rhodospirillales	204441|Rhodospirillales	S	Competence-damaged protein	-	-	-	-	-	-	-	-	-	-	-	-	CinA
HKD1_k127_3844504_6	1173027.Mic7113_6292	3.624e-21	100.0	COG1357@1|root,COG1357@2|Bacteria	1173027.Mic7113_6292|-	S	protein homooligomerization	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3844504_8	469616.FMAG_00381	3.606e-13	74.0	COG1917@1|root,COG1917@2|Bacteria,37AQB@32066|Fusobacteria	32066|Fusobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Cupin_2
HKD1_k127_3844504_3	56780.SYN_01579	3.835e-59	220.0	COG1102@1|root,COG2823@1|root,COG1102@2|Bacteria,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,42TW4@68525|delta/epsilon subdivisions,2WQ5J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
HKD1_k127_3844504_4	1038859.AXAU01000019_gene4817	3.089e-57	219.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,2U07Z@28211|Alphaproteobacteria,3JR8H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Major Facilitator Superfamily	MA20_02120	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_3844504_1	497964.CfE428DRAFT_0790	5.502e-142	463.0	COG3875@1|root,COG3875@2|Bacteria	2|Bacteria	S	lactate racemase activity	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
HKD1_k127_3844504_2	118168.MC7420_6518	1.701e-85	308.0	COG0823@1|root,COG1404@1|root,COG2931@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,COG2931@2|Bacteria,1G04D@1117|Cyanobacteria,1H779@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,Peptidase_S8,SdrD_B
HKD1_k127_3844504_7	1168065.DOK_09429	6.028e-17	95.0	COG2931@1|root,COG4886@1|root,COG2931@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	inlA	-	3.4.24.40	ko:K01406,ko:K13730	ko01503,ko05100,map01503,map05100	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LRR_4,Strep_his_triad
HKD1_k127_3897018_1	1499967.BAYZ01000185_gene4523	2.124e-85	289.0	COG1574@1|root,COG1574@2|Bacteria,2NNTF@2323|unclassified Bacteria	2|Bacteria	S	Amidohydrolase family	ytcJ	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_3897018_5	1209989.TepiRe1_1141	5.352e-07	53.0	2DGWU@1|root,2ZXJT@2|Bacteria,1VNQ5@1239|Firmicutes,257KG@186801|Clostridia	186801|Clostridia	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_3897018_3	909663.KI867150_gene1399	4.758e-16	79.0	2CFNS@1|root,331AJ@2|Bacteria,1NBYG@1224|Proteobacteria,42VZ5@68525|delta/epsilon subdivisions,2WR8A@28221|Deltaproteobacteria,2MS7D@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3897018_0	1499967.BAYZ01000147_gene684	3.22e-116	385.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_3897018_2	357809.Cphy_1264	1.388e-51	188.0	299ND@1|root,2ZWQQ@2|Bacteria,1UZ92@1239|Firmicutes,24J56@186801|Clostridia,2212M@1506553|Lachnoclostridium	186801|Clostridia	S	L-2-amino-thiazoline-4-carboxylic acid hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ATC_hydrolase
HKD1_k127_3913541_10	927677.ALVU02000001_gene4115	1.627e-30	124.0	COG2068@1|root,COG2068@2|Bacteria,1G608@1117|Cyanobacteria	1117|Cyanobacteria	S	MobA-like NTP transferase domain	-	-	1.1.1.328,2.7.7.76	ko:K07141,ko:K19190	ko00760,ko00790,ko01120,map00760,map00790,map01120	-	R10131,R10132,R11582	RC03053	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_3913541_2	1173028.ANKO01000208_gene5099	1.389e-103	356.0	COG1975@1|root,COG1975@2|Bacteria,1G2SP@1117|Cyanobacteria,1H9YC@1150|Oscillatoriales	1117|Cyanobacteria	O	'Xanthine and CO dehydrogenases maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_C,XdhC_CoxI
HKD1_k127_3913541_8	234267.Acid_0388	3.35e-47	183.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_3913541_3	338969.Rfer_0960	6.393e-94	321.0	COG0477@1|root,COG2814@2|Bacteria,1R3WC@1224|Proteobacteria,2VKT9@28216|Betaproteobacteria	28216|Betaproteobacteria	EGP	major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_3913541_7	768671.ThimaDRAFT_4354	2.684e-53	196.0	COG0137@1|root,COG1948@1|root,COG0137@2|Bacteria,COG1948@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1WXPT@135613|Chromatiales	135613|Chromatiales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_3913541_4	1192034.CAP_6380	3.044e-80	285.0	COG1319@1|root,COG1319@2|Bacteria,1MVJS@1224|Proteobacteria,42RX4@68525|delta/epsilon subdivisions,2WNBJ@28221|Deltaproteobacteria,2YY4R@29|Myxococcales	28221|Deltaproteobacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_3913541_0	1192034.CAP_6381	1.169e-196	638.0	COG1529@1|root,COG1529@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YXQ7@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_3913541_6	1267535.KB906767_gene4795	1.21e-58	212.0	COG2080@1|root,COG2080@2|Bacteria,3Y4DP@57723|Acidobacteria,2JJ2F@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S -binding	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2,TAT_signal
HKD1_k127_3913541_1	631454.N177_3086	9.892e-128	421.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,1JNPS@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_3913541_9	1122223.KB890701_gene2173	1.102e-40	162.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	ycf48	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR
HKD1_k127_3913541_12	608506.COB47_1747	0.000952	47.0	COG1433@1|root,COG1433@2|Bacteria,1V7KS@1239|Firmicutes,24MUB@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD1_k127_3913541_5	1301098.PKB_2615	4.316e-59	216.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,1RMMY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31,1.1.1.387	ko:K00020,ko:K19711	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_3913843_0	631362.Thi970DRAFT_01801	5.743e-82	278.0	COG2995@1|root,COG2995@2|Bacteria,1N2QU@1224|Proteobacteria,1S9RM@1236|Gammaproteobacteria,1X0MS@135613|Chromatiales	135613|Chromatiales	S	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	PqiA
HKD1_k127_3913843_2	522306.CAP2UW1_1261	9.147e-10	65.0	COG5164@1|root,COG5164@2|Bacteria,1MX1Z@1224|Proteobacteria,2VKEC@28216|Betaproteobacteria	28216|Betaproteobacteria	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3913843_1	1121438.JNJA01000001_gene2190	1.871e-40	157.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,42T5M@68525|delta/epsilon subdivisions,2WQZ1@28221|Deltaproteobacteria,2MCSU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3915602_7	1123405.AUMM01000075_gene133	1.281e-12	69.0	2DTS4@1|root,33MFD@2|Bacteria,1VKHK@1239|Firmicutes,4I120@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3915602_2	264732.Moth_1709	2.07e-148	482.0	COG0162@1|root,COG0162@2|Bacteria,1TPGN@1239|Firmicutes,247QC@186801|Clostridia,42FBT@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD1_k127_3915602_0	671143.DAMO_1846	3.344e-277	873.0	COG5009@1|root,COG5009@2|Bacteria,2NS4K@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcA	GO:0000270,GO:0003674,GO:0003824,GO:0004180,GO:0004185,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006023,GO:0006024,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0008238,GO:0008360,GO:0008658,GO:0008955,GO:0009002,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0016758,GO:0016787,GO:0017171,GO:0019538,GO:0022603,GO:0022604,GO:0030203,GO:0031224,GO:0031226,GO:0031406,GO:0033218,GO:0033293,GO:0034645,GO:0036094,GO:0042221,GO:0042546,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0065007,GO:0065008,GO:0070008,GO:0070011,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0140096,GO:1901135,GO:1901137,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901681	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	iAF987.Gmet_0354	PCB_OB,Transgly,Transpeptidase
HKD1_k127_3915602_6	743722.Sph21_2661	2.057e-31	132.0	COG4122@1|root,COG4122@2|Bacteria,4PBU0@976|Bacteroidetes,1IZHJ@117747|Sphingobacteriia	976|Bacteroidetes	S	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HKD1_k127_3915602_3	204669.Acid345_0668	7.661e-136	445.0	COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.5.1.48,4.4.1.1,4.4.1.8	ko:K01739,ko:K01758,ko:K01760	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01286,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04941,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD1_k127_3915602_4	717605.Theco_1972	4.822e-97	329.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,4H9Q6@91061|Bacilli,26S6Y@186822|Paenibacillaceae	91061|Bacilli	E	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	GO:0003674,GO:0003824,GO:0004477,GO:0004488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016787,GO:0016810,GO:0016814,GO:0019238,GO:0044237,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_3915602_5	671143.DAMO_1853	7.186e-96	321.0	COG1692@1|root,COG1692@2|Bacteria,2NNW9@2323|unclassified Bacteria	2|Bacteria	S	YmdB-like protein	ymdB	GO:0003674,GO:0003824,GO:0004112,GO:0004113,GO:0008081,GO:0016787,GO:0016788,GO:0042578	-	ko:K02029,ko:K02030,ko:K09769	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	YmdB
HKD1_k127_3915602_1	671143.DAMO_1854	1.366e-170	550.0	COG1418@1|root,COG4372@1|root,COG1418@2|Bacteria,COG4372@2|Bacteria,2NNU5@2323|unclassified Bacteria	2|Bacteria	S	Endoribonuclease that initiates mRNA decay	rny	-	-	ko:K05802,ko:K18682	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko02000,ko03019	1.A.23.1.1	-	-	DUF3552,HD,KH_1
HKD1_k127_3950751_12	1158607.UAU_00094	1.247e-39	149.0	COG0074@1|root,COG0074@2|Bacteria,1UHQ6@1239|Firmicutes,4H9VN@91061|Bacilli,4AZPM@81852|Enterococcaceae	91061|Bacilli	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding,DUF1116,Ligase_CoA
HKD1_k127_3950751_7	159450.NH14_15970	4.203e-109	368.0	COG0402@1|root,COG0402@2|Bacteria,1MX34@1224|Proteobacteria,2VMF2@28216|Betaproteobacteria,1K44U@119060|Burkholderiaceae	28216|Betaproteobacteria	F	N-acyl-D-amino acid deacylase	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_3950751_8	1415755.JQLV01000001_gene1287	3.187e-97	328.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RUFU@1236|Gammaproteobacteria,1XJHF@135619|Oceanospirillales	135619|Oceanospirillales	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_3950751_13	1415755.JQLV01000001_gene1288	1.665e-29	123.0	COG3090@1|root,COG3090@2|Bacteria,1MZNX@1224|Proteobacteria,1SD4H@1236|Gammaproteobacteria,1XM5N@135619|Oceanospirillales	135619|Oceanospirillales	G	TRAP-type C4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_3950751_6	1415755.JQLV01000001_gene1289	1.866e-123	408.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XIS2@135619|Oceanospirillales	135619|Oceanospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_3950751_9	479434.Sthe_0308	1.412e-88	307.0	COG0115@1|root,COG0115@2|Bacteria,2GAM4@200795|Chloroflexi,27XJA@189775|Thermomicrobia	189775|Thermomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_3950751_14	65393.PCC7424_0265	9.311e-29	117.0	COG2929@1|root,COG2929@2|Bacteria,1G805@1117|Cyanobacteria,3KK71@43988|Cyanothece	1117|Cyanobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD1_k127_3950751_15	195253.Syn6312_1026	1.521e-12	71.0	COG3514@1|root,COG3514@2|Bacteria,1G7ND@1117|Cyanobacteria	1117|Cyanobacteria	S	SPTR CopG domain protein DNA-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BrnA_antitoxin
HKD1_k127_3950751_3	1121106.JQKB01000034_gene6005	4.815e-134	437.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2JPHC@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3950751_5	204669.Acid345_2082	1.109e-124	406.0	COG1968@1|root,COG1968@2|Bacteria,3Y2N3@57723|Acidobacteria,2JI1A@204432|Acidobacteriia	204432|Acidobacteriia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_3950751_17	404380.Gbem_2248	2.715e-06	56.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,42Y44@68525|delta/epsilon subdivisions,2WT88@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3950751_19	1169143.KB911034_gene846	0.0008146	43.0	2AGTS@1|root,31721@2|Bacteria,1PYA8@1224|Proteobacteria,2WDI0@28216|Betaproteobacteria,1KACQ@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3950751_11	1499967.BAYZ01000184_gene4558	2.67e-43	165.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_3950751_0	1499967.BAYZ01000184_gene4557	9.874e-173	552.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_3950751_1	1499967.BAYZ01000184_gene4556	2.607e-147	474.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_3950751_2	880073.Calab_2933	6.841e-143	469.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K02481,ko:K07713,ko:K07714	ko02020,map02020	M00499,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3950751_10	56780.SYN_01094	6.638e-48	194.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42PZ5@68525|delta/epsilon subdivisions,2WKWB@28221|Deltaproteobacteria,2MRV9@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_3950751_16	522772.Dacet_2947	6.596e-12	71.0	28VW0@1|root,2ZHXF@2|Bacteria,2GG5K@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3950751_4	1278307.KB906999_gene13	2.528e-127	414.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,2QIGA@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_3960396_7	1206730.BAGA01000077_gene1089	2.665e-09	65.0	COG1028@1|root,COG1028@2|Bacteria,2GK47@201174|Actinobacteria,4FXVP@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_3960396_5	909663.KI867150_gene1576	7.689e-97	325.0	COG2043@1|root,COG2043@2|Bacteria,1R8EH@1224|Proteobacteria,42Q2F@68525|delta/epsilon subdivisions,2WJZN@28221|Deltaproteobacteria,2MQKY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_3960396_0	378806.STAUR_3903	1.04e-241	770.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6,2.3.3.15	ko:K01652,ko:K03852	ko00290,ko00430,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00430,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R05651,R08648	RC00027,RC00106,RC01192,RC02744,RC02893,RC02903,RC02909	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_3960396_1	323848.Nmul_A0131	4.781e-146	471.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2VHBP@28216|Betaproteobacteria,371XV@32003|Nitrosomonadales	28216|Betaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_3960396_3	452637.Oter_3659	2.214e-114	379.0	COG0407@1|root,COG0407@2|Bacteria,46XYK@74201|Verrucomicrobia,3K8MR@414999|Opitutae	414999|Opitutae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_3960396_6	309799.DICTH_1189	1.235e-71	257.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	pepD	-	-	ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin,Trypsin_2
HKD1_k127_3960396_4	1121904.ARBP01000055_gene490	3.73e-102	343.0	COG1638@1|root,COG1638@2|Bacteria,4NGV4@976|Bacteroidetes	976|Bacteroidetes	G	TIGRFAM tripartite ATP-independent periplasmic transporter solute receptor, DctP family	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_3960396_2	1121904.ARBP01000055_gene489	4.787e-121	408.0	COG1593@1|root,COG1593@2|Bacteria,4NHB5@976|Bacteroidetes,47TPP@768503|Cytophagia	2|Bacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_3960396_8	457421.CBFG_01905	9.212e-05	50.0	COG3090@1|root,COG3090@2|Bacteria,1VCVV@1239|Firmicutes,24Q54@186801|Clostridia	186801|Clostridia	G	PFAM Tripartite ATP-independent periplasmic transporter, DctQ component	-	-	-	ko:K21394	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_3983017_0	1121405.dsmv_1020	2.641e-88	299.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,42NRX@68525|delta/epsilon subdivisions,2WK1K@28221|Deltaproteobacteria,2MJ9F@213118|Desulfobacterales	28221|Deltaproteobacteria	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0388	His_biosynth
HKD1_k127_3983017_2	880072.Desac_2871	6.143e-23	100.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,42V6T@68525|delta/epsilon subdivisions,2WRAX@28221|Deltaproteobacteria,2MSGG@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Ribosomal protein S21	rpsU	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_3983017_1	335543.Sfum_1214	5.287e-35	139.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2WQ3S@28221|Deltaproteobacteria,2MQNY@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_4018370_2	452637.Oter_1021	1.363e-57	217.0	COG4188@1|root,COG4188@2|Bacteria	2|Bacteria	KT	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_4,Chlorophyllase2,PAF-AH_p_II
HKD1_k127_4018370_0	1120972.AUMH01000004_gene1492	1.357e-143	473.0	COG0667@1|root,COG0667@2|Bacteria,1TQJC@1239|Firmicutes,4HC0W@91061|Bacilli	91061|Bacilli	C	Aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_4018370_4	118005.AWNK01000007_gene688	9.422e-15	78.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	ybjT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10,TspO_MBR
HKD1_k127_4018370_1	243231.GSU1306	3.606e-86	292.0	COG0613@1|root,COG0613@2|Bacteria,1NFVB@1224|Proteobacteria,43BBY@68525|delta/epsilon subdivisions,2X6R1@28221|Deltaproteobacteria,43VUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	APH,DUF2889,PHP_C
HKD1_k127_4020389_1	335543.Sfum_1464	1.266e-116	381.0	COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_4,Sigma54_activat
HKD1_k127_4020389_0	1267534.KB906755_gene4600	1.177e-139	451.0	28ITY@1|root,2Z8SS@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4020389_3	1267534.KB906755_gene4601	4.544e-45	181.0	COG4129@1|root,COG4129@2|Bacteria,3Y8KP@57723|Acidobacteria,2JNMA@204432|Acidobacteriia	204432|Acidobacteriia	S	Fusaric acid resistance protein-like	-	-	-	-	-	-	-	-	-	-	-	-	FUSC_2
HKD1_k127_4020389_2	748247.AZKH_1971	7.828e-49	180.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_4031170_7	1120973.AQXL01000122_gene191	3.19e-43	173.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,278QJ@186823|Alicyclobacillaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	dppA_1	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_4031170_9	592015.HMPREF1705_01900	1.453e-16	92.0	COG4166@1|root,COG4166@2|Bacteria,3TA34@508458|Synergistetes	508458|Synergistetes	E	family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_4031170_4	768706.Desor_5501	4.544e-76	274.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,26187@186807|Peptococcaceae	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_4031170_10	4536.ONIVA10G11410.1	0.0003371	47.0	COG4886@1|root,KOG0619@2759|Eukaryota,37JP9@33090|Viridiplantae,3GB1E@35493|Streptophyta,3KNQM@4447|Liliopsida,3IEMU@38820|Poales	35493|Streptophyta	S	Leucine-rich repeats, typical (most populated) subfamily	-	-	-	ko:K19613	ko04014,map04014	-	-	-	ko00000,ko00001	-	-	-	LRR_4,LRR_8,ubiquitin
HKD1_k127_4031170_1	671143.DAMO_1326	5.424e-167	531.0	COG0468@1|root,COG0468@2|Bacteria,2NNYW@2323|unclassified Bacteria	2|Bacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0009292,GO:0009294,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030420,GO:0031668,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0044764,GO:0046483,GO:0050896,GO:0051704,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:1901360	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD1_k127_4031170_2	671143.DAMO_1327	1.419e-164	525.0	COG2805@1|root,COG2805@2|Bacteria,2NP0T@2323|unclassified Bacteria	2|Bacteria	NU	Type II/IV secretion system protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_4031170_8	479434.Sthe_1432	2.549e-19	94.0	COG2137@1|root,COG2137@2|Bacteria,2G6WA@200795|Chloroflexi,27YM4@189775|Thermomicrobia	189775|Thermomicrobia	S	RecX family	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD1_k127_4031170_0	335543.Sfum_2527	4.234e-311	976.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2MQ85@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_4031170_6	671143.DAMO_1339	6.948e-58	209.0	COG0688@1|root,COG0688@2|Bacteria,2NPRX@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD1_k127_4031170_5	269799.Gmet_1264	4.467e-59	217.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,42QV4@68525|delta/epsilon subdivisions,2WMR6@28221|Deltaproteobacteria,43SK7@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_4031170_3	671143.DAMO_1341	2.746e-91	305.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
HKD1_k127_4040791_0	335543.Sfum_3679	0.0	1312.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4040791_1	1121396.KB893112_gene1975	1.36e-159	515.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,2MHST@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD1_k127_4040791_2	56780.SYN_00850	6.098e-66	231.0	COG1309@1|root,COG1309@2|Bacteria,1NDME@1224|Proteobacteria,42MYP@68525|delta/epsilon subdivisions,2WKKZ@28221|Deltaproteobacteria,2MRNP@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Domain of unknown function (DUF1956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1956,TetR_N
HKD1_k127_4060991_1	1211115.ALIQ01000169_gene4026	3.865e-93	316.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TTFX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_4060991_3	426117.M446_6721	5.333e-43	170.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,1JUDJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_4060991_0	443598.AUFA01000002_gene2563	4.821e-119	399.0	COG2203@1|root,COG4191@1|root,COG5002@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TTJ0@28211|Alphaproteobacteria,3K6MV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
HKD1_k127_4060991_2	1502851.FG93_00182	1.139e-67	239.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
HKD1_k127_4063904_2	489825.LYNGBM3L_52650	1.97e-56	198.0	COG1012@1|root,COG1012@2|Bacteria,1G1BD@1117|Cyanobacteria,1H7AN@1150|Oscillatoriales	1117|Cyanobacteria	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.3,1.2.1.79	ko:K00128,ko:K00135,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00250,ko00280,ko00310,ko00330,ko00340,ko00350,ko00380,ko00410,ko00561,ko00620,ko00625,ko00650,ko00760,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00250,map00280,map00310,map00330,map00340,map00350,map00380,map00410,map00561,map00620,map00625,map00650,map00760,map00903,map00981,map01100,map01110,map01120,map01130	M00027,M00135	R00264,R00631,R00710,R00713,R00714,R00904,R01752,R01986,R02401,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_4063904_1	414684.RC1_3768	8.587e-112	365.0	COG1083@1|root,COG1083@2|Bacteria,1QACI@1224|Proteobacteria,2U5PV@28211|Alphaproteobacteria,2JU2N@204441|Rhodospirillales	204441|Rhodospirillales	M	Cytidylyltransferase	-	-	2.7.7.43	ko:K00983	ko00520,ko01100,map00520,map01100	-	R01117,R04215	RC00152	ko00000,ko00001,ko01000	-	-	-	CTP_transf_3
HKD1_k127_4063904_0	1191523.MROS_0693	2.743e-232	736.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_4070765_0	1121933.AUHH01000009_gene868	3.802e-115	387.0	COG2217@1|root,COG2217@2|Bacteria,2GIRF@201174|Actinobacteria	201174|Actinobacteria	P	Heavy metal translocating P-type atpase	copA	-	3.6.3.3,3.6.3.4,3.6.3.5,3.6.3.54	ko:K01533,ko:K01534,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5,3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_4070765_1	1007103.AFHW01000032_gene2215	5.16e-18	91.0	COG2318@1|root,COG2318@2|Bacteria,1VW3T@1239|Firmicutes,4HWQI@91061|Bacilli,26Y17@186822|Paenibacillaceae	91061|Bacilli	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_4070765_2	1123247.AUIJ01000001_gene1697	9.681e-12	74.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2TQTD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD1_k127_4074560_2	1303518.CCALI_00571	4.81e-24	102.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_4074560_0	1121127.JAFA01000031_gene4654	2.449e-114	385.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VJ40@28216|Betaproteobacteria,1K4VW@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_4074560_1	1122135.KB893135_gene996	4.46e-26	108.0	COG3033@1|root,COG3033@2|Bacteria,1NG5U@1224|Proteobacteria,2TTAU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	catalyzes the formation of indole and pyruvate from tryptophan	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_4081181_0	292459.STH2228	1.102e-52	194.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,24HV2@186801|Clostridia	186801|Clostridia	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_4081181_2	177439.DP2268	1.435e-06	54.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,2MHQI@213118|Desulfobacterales	28221|Deltaproteobacteria	O	chelatase, subunit ChlI	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_4081181_1	485913.Krac_5357	5.013e-51	184.0	COG0640@1|root,COG1247@1|root,COG0640@2|Bacteria,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	2.3.1.183	ko:K03823,ko:K03892,ko:K05793	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000,ko03000	-	-	-	Acetyltransf_1,Acetyltransf_4,HTH_20,HTH_5,LMWPc
HKD1_k127_4087770_0	106370.Francci3_3546	0.0	1196.0	COG3957@1|root,COG3957@2|Bacteria,2GN27@201174|Actinobacteria,4ERMR@85013|Frankiales	201174|Actinobacteria	G	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD1_k127_4087770_2	909613.UO65_1434	1.093e-127	417.0	COG0282@1|root,COG0282@2|Bacteria,2GJAW@201174|Actinobacteria,4DYVV@85010|Pseudonocardiales	201174|Actinobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD1_k127_4087770_1	1163617.SCD_n00706	0.0	1165.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_4087770_3	1173024.KI912148_gene4321	1.473e-125	415.0	COG0604@1|root,COG0604@2|Bacteria,1G241@1117|Cyanobacteria,1JHGA@1189|Stigonemataceae	1117|Cyanobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_4087770_4	383372.Rcas_0271	3.791e-19	90.0	2E9PK@1|root,333W0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4258
HKD1_k127_4087770_5	383372.Rcas_0270	4.837e-17	83.0	COG5428@1|root,COG5428@2|Bacteria,2G9DH@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HKD1_k127_4094428_2	671143.DAMO_0055	6.367e-55	194.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_4094428_3	243231.GSU2042	1.337e-45	186.0	COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,43RXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_4094428_0	330214.NIDE1256	2.192e-142	469.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4094428_4	243231.GSU1723	6.971e-12	75.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,42MXP@68525|delta/epsilon subdivisions,2WMI1@28221|Deltaproteobacteria,43S3A@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_4121480_1	1502851.FG93_05886	3.011e-49	191.0	COG3221@1|root,COG3221@2|Bacteria,1MXD8@1224|Proteobacteria,2TQMQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Phosphonate ABC transporter	-	-	-	ko:K02044	ko02010,map02010	M00223	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.9	-	-	Phosphonate-bd
HKD1_k127_4121480_0	671143.DAMO_3173	3.623e-170	546.0	COG0001@1|root,COG0001@2|Bacteria,2NP0W@2323|unclassified Bacteria	2|Bacteria	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aldolase_II,Aminotran_3
HKD1_k127_4121480_3	1122609.AUGT01000009_gene3024	2.002e-12	70.0	COG0695@1|root,COG0695@2|Bacteria,2IR0P@201174|Actinobacteria,4DS21@85009|Propionibacteriales	201174|Actinobacteria	O	Glutaredoxin-like domain (DUF836)	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF836
HKD1_k127_4121480_2	1254432.SCE1572_47310	6.285e-27	115.0	COG1475@1|root,COG1475@2|Bacteria,1Q2AH@1224|Proteobacteria,437X8@68525|delta/epsilon subdivisions,2X9QN@28221|Deltaproteobacteria,2YUMN@29|Myxococcales	28221|Deltaproteobacteria	K	ParB-like nuclease domain	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_4124314_0	1123368.AUIS01000014_gene2294	1.035e-152	493.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,2NBZH@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_4124314_1	1510531.JQJJ01000008_gene4024	7.876e-31	122.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,3JSW3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	MA20_17495	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HKD1_k127_4134972_0	671143.DAMO_2104	2.4e-322	1007.0	COG1032@1|root,COG5011@1|root,COG1032@2|Bacteria,COG5011@2|Bacteria,2NNKI@2323|unclassified Bacteria	2|Bacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344,Radical_SAM
HKD1_k127_4134972_8	1499967.BAYZ01000029_gene1223	1.098e-143	477.0	COG1530@1|root,COG1530@2|Bacteria,2NNQR@2323|unclassified Bacteria	2|Bacteria	J	Ribonuclease E/G family	rng	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005856,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008996,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	3.1.26.12	ko:K08300,ko:K08301	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD1_k127_4134972_23	471854.Dfer_1489	1.358e-17	96.0	COG0642@1|root,COG0745@1|root,COG3292@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3292@2|Bacteria,4NDXU@976|Bacteroidetes,47JBS@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_18,HisKA,Reg_prop,Response_reg,Y_Y_Y
HKD1_k127_4134972_21	671143.DAMO_0327	4.745e-30	127.0	COG0261@1|root,COG0261@2|Bacteria,2NPSX@2323|unclassified Bacteria	2|Bacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD1_k127_4134972_20	671143.DAMO_0328	1.148e-31	125.0	COG0211@1|root,COG0211@2|Bacteria,2NPSU@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0000027,GO:0001558,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0040008,GO:0042254,GO:0042255,GO:0042256,GO:0042273,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0044877,GO:0048518,GO:0050789,GO:0050794,GO:0051128,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1902626,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD1_k127_4134972_9	671143.DAMO_0330	8.163e-134	434.0	COG0536@1|root,COG0536@2|Bacteria,2NNS6@2323|unclassified Bacteria	2|Bacteria	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	GO:0000287,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0019538,GO:0032991,GO:0036211,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0046777,GO:0046872,GO:0071704,GO:0071944,GO:1901564,GO:1990904	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HKD1_k127_4134972_10	671143.DAMO_0331	2.82e-128	422.0	COG0263@1|root,COG0263@2|Bacteria,2NQMJ@2323|unclassified Bacteria	2|Bacteria	E	PUA domain	proB	GO:0003674,GO:0003824,GO:0004349,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0018130,GO:0019202,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3198	AA_kinase,PUA
HKD1_k127_4134972_2	671143.DAMO_0332	6.71e-173	553.0	COG0014@1|root,COG0014@2|Bacteria,2NQM3@2323|unclassified Bacteria	2|Bacteria	E	Aldehyde dehydrogenase family	proA	GO:0003674,GO:0003824,GO:0004350,GO:0006082,GO:0006520,GO:0006560,GO:0006561,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0293,iYO844.BSU13130	Aldedh
HKD1_k127_4134972_13	671143.DAMO_0333	3.604e-104	343.0	COG1057@1|root,COG1057@2|Bacteria,2NPJU@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CTP_transf_like
HKD1_k127_4134972_18	671143.DAMO_0334	6.59e-37	146.0	COG0799@1|root,COG0799@2|Bacteria,2NPYI@2323|unclassified Bacteria	2|Bacteria	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006417,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0043021,GO:0043023,GO:0044087,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0080090,GO:0090069,GO:0090071,GO:2000112,GO:2000113	2.7.7.18	ko:K00969,ko:K09710	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	RsfS
HKD1_k127_4134972_19	671143.DAMO_0335	4.786e-34	135.0	COG1734@1|root,COG1734@2|Bacteria,2NQ6S@2323|unclassified Bacteria	2|Bacteria	T	Prokaryotic dksA/traR C4-type zinc finger	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_4134972_15	314345.SPV1_00195	9.147e-53	212.0	COG0515@1|root,COG4252@1|root,COG0515@2|Bacteria,COG4252@2|Bacteria,1MV1P@1224|Proteobacteria	1224|Proteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHASE2,Pkinase
HKD1_k127_4134972_17	1131813.AQVT01000001_gene413	5.434e-37	149.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,2TV7G@28211|Alphaproteobacteria,1JTTY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Competence protein	comF	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_4134972_4	671143.DAMO_0339	1.409e-167	533.0	COG0057@1|root,COG0057@2|Bacteria,2NNPP@2323|unclassified Bacteria	2|Bacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_4134972_7	338963.Pcar_1332	5.078e-146	473.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,42N4P@68525|delta/epsilon subdivisions,2WJ0B@28221|Deltaproteobacteria,43S14@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_4134972_14	1009370.ALO_11584	7.367e-86	291.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,4H27A@909932|Negativicutes	909932|Negativicutes	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD1_k127_4134972_22	671143.DAMO_0343	6.594e-27	118.0	COG1314@1|root,COG1314@2|Bacteria,2NPYV@2323|unclassified Bacteria	2|Bacteria	U	Preprotein translocase SecG subunit	secG	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0022857,GO:0022884,GO:0031522,GO:0032978,GO:0032991,GO:0033036,GO:0033365,GO:0034613,GO:0042886,GO:0042887,GO:0043952,GO:0044464,GO:0045047,GO:0045184,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD1_k127_4134972_1	243231.GSU1433	3.174e-211	676.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,42MFK@68525|delta/epsilon subdivisions,2WKBU@28221|Deltaproteobacteria,43U0I@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K02035,ko:K13893	ko02010,ko02024,map02010,map02024	M00239,M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD1_k127_4134972_12	706587.Desti_5516	3.575e-116	387.0	COG0601@1|root,COG0601@2|Bacteria,1NS80@1224|Proteobacteria,42N5D@68525|delta/epsilon subdivisions,2WIRR@28221|Deltaproteobacteria,2MQBC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_4134972_11	243231.GSU1435	2.093e-122	398.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_4134972_6	574087.Acear_2286	1.292e-146	474.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,3WBHG@53433|Halanaerobiales	186801|Clostridia	H	PFAM Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_4134972_3	671143.DAMO_1876	2.124e-170	546.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	nla6	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4134972_5	671143.DAMO_1877	1.136e-152	501.0	COG5000@1|root,COG5000@2|Bacteria,2NQZA@2323|unclassified Bacteria	2|Bacteria	T	Multi-sensor signal transduction histidine kinase	ntrB	-	2.7.13.3	ko:K07710	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD1_k127_4134972_24	66692.ABC2711	7.775e-11	68.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,4H9KP@91061|Bacilli,1ZBGS@1386|Bacillus	91061|Bacilli	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoP	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4134972_26	357276.EL88_10065	1.562e-05	55.0	COG2885@1|root,COG2885@2|Bacteria,4NEGF@976|Bacteroidetes,2FNU2@200643|Bacteroidia,4AMBV@815|Bacteroidaceae	976|Bacteroidetes	M	COG2885 Outer membrane protein and related peptidoglycan-associated	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
HKD1_k127_4134972_16	671143.DAMO_2095	6.702e-48	185.0	COG0744@1|root,COG0744@2|Bacteria,2NNMB@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase	mrcB	-	2.4.1.129,3.4.16.4	ko:K05365,ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HKD1_k127_4160158_1	880072.Desac_2344	7.671e-107	354.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42P19@68525|delta/epsilon subdivisions,2WK00@28221|Deltaproteobacteria,2MR1N@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K19595	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2.25,2.A.6.2.34,8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_4160158_0	269799.Gmet_1664	0.0	1471.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TFN@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K19594	-	M00768,M00769	-	-	ko00000,ko00002,ko01504,ko02000	2.A.6.2,2.A.6.2.25,2.A.6.2.34	-	-	ACR_tran
HKD1_k127_4160158_2	885272.JonanDRAFT_0227	0.0003134	46.0	COG1247@1|root,COG1247@2|Bacteria	2|Bacteria	M	phosphinothricin N-acetyltransferase activity	-	-	2.3.1.183,2.3.1.82	ko:K03823,ko:K18816	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	br01600,ko00000,ko00001,ko01000,ko01504	-	-	-	Acetyltransf_1
HKD1_k127_4168501_37	866536.Belba_0401	1.249e-08	57.0	COG0452@1|root,COG0452@2|Bacteria,4NE46@976|Bacteroidetes,47MHR@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_4168501_31	648996.Theam_0217	1.151e-30	139.0	COG1578@1|root,COG1578@2|Bacteria,2G42I@200783|Aquificae	200783|Aquificae	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
HKD1_k127_4168501_20	1128421.JAGA01000002_gene1501	9.668e-79	273.0	COG0351@1|root,COG0351@2|Bacteria,2NP3M@2323|unclassified Bacteria	2|Bacteria	H	Phosphomethylpyrimidine kinase	thiD	GO:0008150,GO:0040007	2.5.1.3,2.7.1.35,2.7.1.49,2.7.4.7,4.1.99.17	ko:K00868,ko:K00941,ko:K03147,ko:K21219	ko00730,ko00750,ko01100,map00730,map00750,map01100	M00127	R00174,R01909,R02493,R03223,R03471,R03472,R04509,R10712	RC00002,RC00017,RC00224,RC03251,RC03252,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS03115	Phos_pyr_kin
HKD1_k127_4168501_12	671143.DAMO_2417	4.244e-122	425.0	COG0457@1|root,COG0741@1|root,COG1729@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,COG1729@2|Bacteria,2NPKN@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K07114,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.A.13.2.2,1.A.13.2.3	GH23	-	SLT,TPR_16,TPR_6
HKD1_k127_4168501_9	671143.DAMO_2416	7.13e-136	441.0	COG0182@1|root,COG0182@2|Bacteria,2NNM7@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0072	IF-2B
HKD1_k127_4168501_30	331869.BAL199_17958	4.09e-36	142.0	2DS7S@1|root,33EWX@2|Bacteria,1NDGE@1224|Proteobacteria,2UH4Z@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4168501_35	1121012.AUKX01000070_gene1852	1.493e-13	74.0	2EKA0@1|root,33E0A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4168501_16	56780.SYN_02543	4.035e-106	354.0	COG2199@1|root,COG3829@1|root,COG3706@2|Bacteria,COG3829@2|Bacteria,1RAKG@1224|Proteobacteria,42QYD@68525|delta/epsilon subdivisions,2WN6A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_9
HKD1_k127_4168501_33	1121405.dsmv_0961	2.475e-27	118.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,42V1U@68525|delta/epsilon subdivisions,2WR76@28221|Deltaproteobacteria,2MKCK@213118|Desulfobacterales	28221|Deltaproteobacteria	U	Preprotein translocase subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD1_k127_4168501_8	671143.DAMO_2407	1.359e-141	473.0	COG0343@1|root,COG0343@2|Bacteria,2NNQS@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008270,GO:0008479,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	iECW_1372.ECW_m0475,iWFL_1372.ECW_m0475	TGT
HKD1_k127_4168501_18	338963.Pcar_1895	3.682e-100	352.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,42MMG@68525|delta/epsilon subdivisions,2WJ9W@28221|Deltaproteobacteria,43S17@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Queuosine biosynthesis protein	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD1_k127_4168501_23	338966.Ppro_1802	1.17e-60	227.0	COG2385@1|root,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria,42RZE@68525|delta/epsilon subdivisions,2WNH8@28221|Deltaproteobacteria,43TQU@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	PFAM Stage II sporulation	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
HKD1_k127_4168501_34	671143.DAMO_2405	9.275e-24	103.0	29Y14@1|root,30JU1@2|Bacteria,2NRYB@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD1_k127_4168501_6	671143.DAMO_2404	4.377e-157	512.0	COG2255@1|root,COG2255@2|Bacteria,2NNUG@2323|unclassified Bacteria	2|Bacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0031668,GO:0033554,GO:0050896,GO:0051716,GO:0071496	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD1_k127_4168501_22	671143.DAMO_2403	2.983e-63	228.0	COG0632@1|root,COG0632@2|Bacteria,2NPR6@2323|unclassified Bacteria	2|Bacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	GO:0000217,GO:0000400,GO:0000724,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003678,GO:0003824,GO:0004386,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009314,GO:0009378,GO:0009379,GO:0009432,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0022607,GO:0031668,GO:0032392,GO:0032508,GO:0032991,GO:0033202,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051276,GO:0051289,GO:0051716,GO:0065003,GO:0071103,GO:0071496,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD1_k127_4168501_26	324602.Caur_1044	1.105e-45	173.0	COG0817@1|root,COG0817@2|Bacteria,2G6MA@200795|Chloroflexi,375KP@32061|Chloroflexia	32061|Chloroflexia	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD1_k127_4168501_17	671143.DAMO_2401	1.457e-104	345.0	COG0217@1|root,COG0217@2|Bacteria,2NNSI@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulatory protein	yebC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD1_k127_4168501_28	1382304.JNIL01000001_gene2857	8.943e-44	167.0	COG1954@1|root,COG1954@2|Bacteria,1V4IE@1239|Firmicutes,4I613@91061|Bacilli,27ACJ@186823|Alicyclobacillaceae	91061|Bacilli	K	Glycerol-3-phosphate responsive antiterminator	-	-	-	ko:K02443	-	-	-	-	ko00000,ko03000	-	-	-	G3P_antiterm
HKD1_k127_4168501_14	479434.Sthe_3109	7.583e-117	404.0	COG0578@1|root,COG0578@2|Bacteria,2G8C0@200795|Chloroflexi,27Y8H@189775|Thermomicrobia	189775|Thermomicrobia	C	C-terminal domain of alpha-glycerophosphate oxidase	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD1_k127_4168501_25	1536769.P40081_06475	1.267e-47	186.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,4HFNQ@91061|Bacilli,26SCR@186822|Paenibacillaceae	91061|Bacilli	C	glycerophosphoryl diester phosphodiesterase	yqiK	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD1_k127_4168501_3	1380394.JADL01000002_gene1534	1.731e-190	605.0	COG1653@1|root,COG1653@2|Bacteria,1MVMW@1224|Proteobacteria,2TQKV@28211|Alphaproteobacteria,2JPHX@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
HKD1_k127_4168501_10	1380394.JADL01000002_gene1535	2.637e-131	426.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,2TSGN@28211|Alphaproteobacteria,2JQ6I@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HKD1_k127_4168501_11	1380394.JADL01000002_gene1536	1.142e-126	413.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TSYA@28211|Alphaproteobacteria,2JQYA@204441|Rhodospirillales	204441|Rhodospirillales	G	probably responsible for the translocation of the substrate across the membrane	ugpE	-	-	ko:K05815	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HKD1_k127_4168501_1	246194.CHY_1839	1.857e-215	682.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,42FD3@68295|Thermoanaerobacterales	186801|Clostridia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD1_k127_4168501_4	335543.Sfum_3495	2.058e-190	601.0	COG1840@1|root,COG1840@2|Bacteria,1PFBM@1224|Proteobacteria,4324D@68525|delta/epsilon subdivisions,2WX6N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD1_k127_4168501_5	335543.Sfum_3496	2.548e-164	524.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2MRN0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD1_k127_4168501_0	335543.Sfum_3497	1.23e-292	906.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,42TI5@68525|delta/epsilon subdivisions,2WQR8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_4168501_36	1120999.JONM01000001_gene1328	4.664e-13	78.0	COG0500@1|root,COG2226@2|Bacteria,1PN45@1224|Proteobacteria,2VNPX@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_4168501_7	234267.Acid_0546	2.023e-143	467.0	COG0498@1|root,COG0498@2|Bacteria,3Y2GX@57723|Acidobacteria	57723|Acidobacteria	E	TIGRFAM Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4168501_38	1276756.AUEX01000008_gene3211	0.000877	44.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2VJSM@28216|Betaproteobacteria,4AAJW@80864|Comamonadaceae	28216|Betaproteobacteria	P	heavy metal translocating P-type ATPase	ccoI	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_4168501_32	1278073.MYSTI_06777	1.619e-27	123.0	COG1999@1|root,COG1999@2|Bacteria,1N19Q@1224|Proteobacteria,42XV1@68525|delta/epsilon subdivisions,2WSUD@28221|Deltaproteobacteria,2YV76@29|Myxococcales	28221|Deltaproteobacteria	S	protein SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_4168501_27	338969.Rfer_4025	5.365e-44	161.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,2VSH3@28216|Betaproteobacteria,4AEBC@80864|Comamonadaceae	28216|Betaproteobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_4168501_21	1267535.KB906767_gene277	6.014e-74	254.0	2DB97@1|root,33TRP@2|Bacteria,3Y7NY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4168501_29	497964.CfE428DRAFT_3867	1.334e-39	149.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
HKD1_k127_4168501_2	330214.NIDE3482	5.733e-213	666.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HKD1_k127_4168501_19	56107.Cylst_4769	1.363e-86	293.0	COG1028@1|root,COG1028@2|Bacteria,1G2ZD@1117|Cyanobacteria,1HK9F@1161|Nostocales	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD1_k127_4168501_13	666685.R2APBS1_0246	1.085e-119	388.0	COG0262@1|root,COG0262@2|Bacteria,1MU1W@1224|Proteobacteria,1S2TQ@1236|Gammaproteobacteria,1X4M1@135614|Xanthomonadales	135614|Xanthomonadales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_4168501_15	1300345.LF41_901	1.904e-114	394.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_4168501_24	876269.ARWA01000001_gene2316	2.314e-48	176.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,2VG1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HKD1_k127_4177429_0	1499967.BAYZ01000059_gene4772	0.0	1142.0	COG1894@1|root,COG1894@2|Bacteria,2NNM1@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.12.1.3	ko:K18331	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,NADH_4Fe-4S,Pyr_redox_2,SLBB
HKD1_k127_4177429_2	1047013.AQSP01000091_gene643	3.974e-76	262.0	COG3383@1|root,COG3383@2|Bacteria,2NNXH@2323|unclassified Bacteria	2|Bacteria	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.17.1.9,1.6.5.3	ko:K00123,ko:K00336,ko:K18332	ko00190,ko00630,ko00680,ko01100,ko01120,ko01200,map00190,map00630,map00680,map01100,map01120,map01200	M00144	R00519,R11945	RC00061,RC02796	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS03470	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_21,Fer4_7,NADH-G_4Fe-4S_3
HKD1_k127_4177429_1	1047013.AQSP01000091_gene644	1.245e-240	753.0	COG1304@1|root,COG1304@2|Bacteria	2|Bacteria	C	FMN binding	yahG	-	-	-	-	-	-	-	-	-	-	-	DUF1116,FMN_dh,Glu_synthase
HKD1_k127_4182309_0	926550.CLDAP_40590	8.213e-90	305.0	COG0535@1|root,COG2002@1|root,COG0535@2|Bacteria,COG2002@2|Bacteria,2G75Y@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM,SPASM
HKD1_k127_4182309_2	1265505.ATUG01000002_gene2495	3.537e-60	216.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,2MM84@213118|Desulfobacterales	28221|Deltaproteobacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
HKD1_k127_4182309_4	350688.Clos_1108	0.0002224	46.0	COG0535@1|root,COG0535@2|Bacteria,1V0CR@1239|Firmicutes,24BIB@186801|Clostridia,36G4D@31979|Clostridiaceae	186801|Clostridia	C	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD1_k127_4182309_3	1226994.AMZB01000121_gene3420	5.274e-26	114.0	COG1846@1|root,COG1846@2|Bacteria,1RF3U@1224|Proteobacteria,1S4H8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_4182309_1	1121428.DESHY_150111___1	8.342e-78	277.0	COG0500@1|root,COG1246@1|root,COG1246@2|Bacteria,COG2226@2|Bacteria,1U9KN@1239|Firmicutes	1239|Firmicutes	E	methyltransferase	ywlB	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD1_k127_4188983_11	251221.35211938	3.038e-24	112.0	COG0822@1|root,COG0822@2|Bacteria,1G590@1117|Cyanobacteria	1117|Cyanobacteria	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_4188983_2	671143.DAMO_2380	1.477e-184	588.0	COG0520@1|root,COG0520@2|Bacteria,2NNS0@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_4188983_4	1382359.JIAL01000001_gene680	4.654e-135	455.0	COG0719@1|root,COG0719@2|Bacteria,3Y4EK@57723|Acidobacteria	57723|Acidobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_4188983_5	1382359.JIAL01000001_gene679	1.004e-114	374.0	COG0396@1|root,COG0396@2|Bacteria,3Y3S4@57723|Acidobacteria	57723|Acidobacteria	O	ABC transporter	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD1_k127_4188983_0	1382359.JIAL01000001_gene678	1.54e-274	849.0	COG0719@1|root,COG0719@2|Bacteria,3Y2IX@57723|Acidobacteria	57723|Acidobacteria	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_4188983_12	671143.DAMO_2387	2.543e-22	101.0	COG0745@1|root,COG0745@2|Bacteria	671143.DAMO_2387|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4188983_1	671143.DAMO_3123	9.926e-187	593.0	COG2204@1|root,COG2204@2|Bacteria,2NQHI@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4188983_3	671143.DAMO_3124	2.009e-152	501.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,SpoIIE,sCache_3_2
HKD1_k127_4188983_8	246197.MXAN_6341	2.379e-60	223.0	COG0404@1|root,COG0404@2|Bacteria,1QX3Y@1224|Proteobacteria,43BWD@68525|delta/epsilon subdivisions,2X775@28221|Deltaproteobacteria,2YVVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605,ko:K06980	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD1_k127_4188983_9	1206735.BAGG01000259_gene6421	1.086e-52	195.0	COG1028@1|root,COG1028@2|Bacteria,2H0SM@201174|Actinobacteria,4FXXY@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	-	ko:K12420	ko00253,ko01056,ko01130,map00253,map01056,map01130	M00778	R06642,R09262,R09263,R09264	RC00029,RC00144	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	adh_short
HKD1_k127_4188983_10	671143.DAMO_2863	6.349e-48	178.0	COG2096@1|root,COG2096@2|Bacteria,2NPP8@2323|unclassified Bacteria	2|Bacteria	S	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	pduO	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,Haem_degrading
HKD1_k127_4188983_6	582515.KR51_00014290	5.041e-75	261.0	COG2912@1|root,COG2912@2|Bacteria,1G11S@1117|Cyanobacteria	1117|Cyanobacteria	S	COGs COG2912 conserved	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HKD1_k127_4188983_7	671143.DAMO_3017	4.869e-69	257.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	mhpC	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD1_k127_4192197_11	352165.HMPREF7215_2134	1.097e-64	230.0	COG1638@1|root,COG1638@2|Bacteria,3TAE1@508458|Synergistetes	508458|Synergistetes	G	transporter solute receptor, DctP family	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4192197_10	761193.Runsl_4980	4.289e-78	274.0	COG1373@1|root,COG1373@2|Bacteria,4NEMX@976|Bacteroidetes,47MKR@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HKD1_k127_4192197_14	649638.Trad_2182	1.485e-12	72.0	COG1653@1|root,COG1653@2|Bacteria,1WJQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_4192197_7	543728.Vapar_6265	9.457e-83	292.0	COG1653@1|root,COG1653@2|Bacteria,1N98V@1224|Proteobacteria,2VXBA@28216|Betaproteobacteria,4AJMM@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_4192197_6	1123060.JONP01000027_gene3494	7.407e-85	300.0	COG0395@1|root,COG0395@2|Bacteria,1QHIK@1224|Proteobacteria,2U2IY@28211|Alphaproteobacteria,2JT59@204441|Rhodospirillales	204441|Rhodospirillales	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_4192197_5	296591.Bpro_3816	5.608e-93	315.0	COG1175@1|root,COG1175@2|Bacteria,1NAGS@1224|Proteobacteria,2VTWH@28216|Betaproteobacteria,4AF5B@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
HKD1_k127_4192197_9	543728.Vapar_6265	1.084e-80	285.0	COG1653@1|root,COG1653@2|Bacteria,1N98V@1224|Proteobacteria,2VXBA@28216|Betaproteobacteria,4AJMM@80864|Comamonadaceae	28216|Betaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_4192197_0	1051632.TPY_0247	3.1e-225	712.0	COG3960@1|root,COG3960@2|Bacteria,1UKIM@1239|Firmicutes,25FY2@186801|Clostridia	186801|Clostridia	S	Thiamine pyrophosphate enzyme, central domain	-	-	4.1.1.47	ko:K01608	ko00630,ko01100,map00630,map01100	-	R00013	RC00899	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_4192197_15	246197.MXAN_4067	4.264e-11	67.0	COG1977@1|root,COG1977@2|Bacteria,1N15U@1224|Proteobacteria,42XSH@68525|delta/epsilon subdivisions,2WTDG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_4192197_1	641491.DND132_2395	1.794e-190	614.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MAH4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_4192197_4	251229.Chro_1581	2.907e-102	352.0	COG1914@1|root,COG1914@2|Bacteria,1GIFV@1117|Cyanobacteria,3VM6A@52604|Pleurocapsales	1117|Cyanobacteria	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4192197_12	1134413.ANNK01000142_gene3024	4.907e-57	210.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,4HCSI@91061|Bacilli,1ZDR0@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD1_k127_4192197_3	1125701.HMPREF1221_01718	8.41e-119	413.0	COG1995@1|root,COG1995@2|Bacteria,2J6SI@203691|Spirochaetes	203691|Spirochaetes	C	Belongs to the PdxA family	-	-	1.1.1.408,1.1.1.409	ko:K22024	-	-	-	-	ko00000,ko01000	-	-	-	PdxA
HKD1_k127_4192197_2	886293.Sinac_6684	3.886e-120	395.0	COG0473@1|root,COG0473@2|Bacteria,2IXJZ@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_4192197_8	90371.CY43_23495	4.028e-82	288.0	COG1820@1|root,COG1820@2|Bacteria,1QUJ0@1224|Proteobacteria,1T26K@1236|Gammaproteobacteria,3ZJRE@590|Salmonella	1236|Gammaproteobacteria	E	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation	iadA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008270,GO:0008798,GO:0016787,GO:0019538,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	-	ko:K01305	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_4192197_13	1131730.BAVI_09591	1.266e-52	196.0	COG1028@1|root,COG1028@2|Bacteria,1V0K4@1239|Firmicutes,4HEDS@91061|Bacilli,1ZMYP@1386|Bacillus	91061|Bacilli	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_419692_6	1196029.ALIM01000034_gene1689	9.792e-94	321.0	COG1541@1|root,COG1541@2|Bacteria,1UYJ0@1239|Firmicutes,4HD80@91061|Bacilli,1ZFEK@1386|Bacillus	91061|Bacilli	H	Acyl-protein synthetase, LuxE	-	-	-	-	-	-	-	-	-	-	-	-	LuxE
HKD1_k127_419692_1	999630.TUZN_2066	1.357e-106	357.0	COG1064@1|root,arCOG01455@2157|Archaea,2XQ4K@28889|Crenarchaeota	28889|Crenarchaeota	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	1.1.1.1	ko:K13953,ko:K18382	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10703	RC00050,RC00087,RC00088,RC00099,RC00116,RC00545,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_419692_14	1123501.KB902276_gene1401	2.24e-76	267.0	COG0395@1|root,COG1175@1|root,COG0395@2|Bacteria,COG1175@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	MA20_03550	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_419692_23	35754.JNYJ01000026_gene8817	3.28e-63	228.0	COG0395@1|root,COG1175@1|root,COG0395@2|Bacteria,COG1175@2|Bacteria,2GJ3P@201174|Actinobacteria,4DBPR@85008|Micromonosporales	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_419692_30	479432.Sros_7725	9.377e-14	84.0	COG1653@1|root,COG1653@2|Bacteria,2GNYN@201174|Actinobacteria,4ER0E@85012|Streptosporangiales	201174|Actinobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027,ko:K17329	ko02010,map02010	M00207,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.33	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_419692_26	1123508.JH636445_gene6758	1.756e-25	110.0	2E4SV@1|root,32ZM7@2|Bacteria,2J3ZW@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_419692_10	926569.ANT_04940	1.782e-81	280.0	COG1575@1|root,COG1575@2|Bacteria	2|Bacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_419692_34	1304874.JAFY01000002_gene834	5.047e-05	47.0	COG1720@1|root,COG1720@2|Bacteria,3TBKI@508458|Synergistetes	508458|Synergistetes	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_419692_33	1304874.JAFY01000002_gene834	2.14e-07	55.0	COG1720@1|root,COG1720@2|Bacteria,3TBKI@508458|Synergistetes	508458|Synergistetes	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_419692_17	471853.Bcav_3392	3.92e-74	263.0	COG4948@1|root,COG4948@2|Bacteria,2GT81@201174|Actinobacteria	201174|Actinobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6,4.2.1.8	ko:K01684,ko:K08323	ko00040,ko00052,ko01100,ko01120,map00040,map00052,map01100,map01120	M00061,M00552	R03033,R05606	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_419692_7	1449126.JQKL01000036_gene1922	2.413e-92	320.0	COG1804@1|root,COG1804@2|Bacteria,1TP54@1239|Firmicutes,24AFB@186801|Clostridia	186801|Clostridia	C	CoA-transferase family III	-	-	2.8.3.19	ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD1_k127_419692_24	1121085.AUCI01000045_gene71	1.161e-53	202.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_419692_27	1411123.JQNH01000001_gene577	4.677e-21	99.0	COG0346@1|root,COG0346@2|Bacteria,1RHBM@1224|Proteobacteria,2U9Q5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HKD1_k127_419692_32	1382356.JQMP01000001_gene1074	1.456e-10	72.0	COG1804@1|root,COG1804@2|Bacteria,2G7MX@200795|Chloroflexi,27YZQ@189775|Thermomicrobia	189775|Thermomicrobia	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_419692_5	1121085.AUCI01000045_gene71	5.462e-96	324.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_419692_19	469383.Cwoe_4284	7.853e-72	254.0	COG1129@1|root,COG1129@2|Bacteria,2GJDV@201174|Actinobacteria,4CR9Y@84995|Rubrobacteria	84995|Rubrobacteria	G	ATPases associated with a variety of cellular activities	-	-	3.6.3.17	ko:K10545	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.4	-	-	ABC_tran
HKD1_k127_419692_20	1040986.ATYO01000011_gene5560	2.347e-70	249.0	COG1879@1|root,COG1879@2|Bacteria,1NRXG@1224|Proteobacteria,2TW5I@28211|Alphaproteobacteria,43R9W@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Periplasmic binding protein-like domain	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD1_k127_419692_18	1038860.AXAP01000001_gene6409	2.098e-72	257.0	COG1172@1|root,COG1172@2|Bacteria,1MX7D@1224|Proteobacteria,2U0D6@28211|Alphaproteobacteria,3JW92@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Branched-chain amino acid transport system / permease component	MA20_14315	-	-	ko:K02057,ko:K10440	ko02010,map02010	M00212,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD1_k127_419692_0	1121472.AQWN01000007_gene1130	1.333e-118	395.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,25ZZC@186807|Peptococcaceae	186801|Clostridia	C	PFAM Transketolase	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_419692_16	555079.Toce_2031	5.253e-75	265.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_419692_13	1411123.JQNH01000001_gene105	2.07e-76	271.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_419692_9	1121085.AUCI01000045_gene72	7.007e-83	289.0	COG2057@1|root,COG2057@2|Bacteria,1UDE4@1239|Firmicutes,4HDQF@91061|Bacilli,1ZHM8@1386|Bacillus	91061|Bacilli	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
HKD1_k127_419692_2	1121085.AUCI01000045_gene70	8.572e-104	345.0	COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,4HGBM@91061|Bacilli,1ZIHE@1386|Bacillus	91061|Bacilli	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_419692_22	1120956.JHZK01000001_gene3302	1.528e-63	230.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2V8IN@28211|Alphaproteobacteria,1JQ8U@119043|Rhodobiaceae	1224|Proteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_419692_3	1121085.AUCI01000045_gene78	3.897e-103	349.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,1ZC02@1386|Bacillus	91061|Bacilli	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_419692_29	314231.FP2506_17509	6.42e-17	89.0	COG3090@1|root,COG3090@2|Bacteria,1RAZ5@1224|Proteobacteria	1224|Proteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctQ	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_419692_12	926550.CLDAP_24790	7.685e-78	279.0	COG1070@1|root,COG1070@2|Bacteria	2|Bacteria	G	xylulokinase activity	-	-	2.7.1.12,2.7.1.17,2.7.1.215,2.7.1.5	ko:K00848,ko:K00851,ko:K00854,ko:K00862	ko00030,ko00040,ko00051,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00040,map00051,map01100,map01110,map01120,map01130,map01200	M00014	R01639,R01737,R01902,R03014,R11536	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_419692_21	1120746.CCNL01000017_gene2770	1.097e-66	238.0	COG2057@1|root,COG2057@2|Bacteria,2NP63@2323|unclassified Bacteria	2|Bacteria	I	Coenzyme A transferase	catJ	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	2.8.3.12	ko:K01039,ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_419692_15	1120746.CCNL01000017_gene2771	4.529e-76	266.0	COG1788@1|root,COG1788@2|Bacteria,2NR4U@2323|unclassified Bacteria	2|Bacteria	I	Coenzyme A transferase	gctA	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_419692_11	1121085.AUCI01000045_gene72	1.158e-78	278.0	COG2057@1|root,COG2057@2|Bacteria,1UDE4@1239|Firmicutes,4HDQF@91061|Bacilli,1ZHM8@1386|Bacillus	91061|Bacilli	I	Coenzyme A transferase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_trans
HKD1_k127_419692_8	1121085.AUCI01000045_gene70	1.143e-91	329.0	COG1788@1|root,COG1788@2|Bacteria,1UYH2@1239|Firmicutes,4HGBM@91061|Bacilli,1ZIHE@1386|Bacillus	91061|Bacilli	I	Coenzyme A transferase	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_419692_4	331869.BAL199_12431	6.881e-98	336.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,4BRHR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_419692_31	1121861.KB899910_gene802	4.274e-13	76.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_419692_25	1353528.DT23_02630	4.088e-50	195.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria,2XPDK@285107|Thioclava	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_419692_28	411902.CLOBOL_00594	1.075e-18	87.0	COG1737@1|root,COG1737@2|Bacteria,1TR0N@1239|Firmicutes,24BR4@186801|Clostridia,220Q5@1506553|Lachnoclostridium	186801|Clostridia	K	Helix-turn-helix domain, rpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD1_k127_4222085_0	330214.NIDE1256	7.107e-140	458.0	COG2204@1|root,COG2204@2|Bacteria,3J10B@40117|Nitrospirae	40117|Nitrospirae	T	Sigma-54 interaction domain	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4222085_4	1123274.KB899408_gene3937	5.197e-19	94.0	COG2204@1|root,COG2204@2|Bacteria,2J5NY@203691|Spirochaetes	203691|Spirochaetes	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4222085_3	1144275.COCOR_03896	1.253e-31	136.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	ko:K04772,ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	FHA,Trypsin_2
HKD1_k127_4222085_1	330214.NIDE2777	7.692e-69	248.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	yddE	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_4222085_2	497964.CfE428DRAFT_2876	1.008e-57	205.0	COG2818@1|root,COG2818@2|Bacteria,46SS9@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD1_k127_4231183_2	1216976.AX27061_2956	3.659e-143	461.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,3T4SG@506|Alcaligenaceae	28216|Betaproteobacteria	E	COG0520 Selenocysteine lyase	cefD	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_4231183_0	1003200.AXXA_25535	4.59e-190	613.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2VKA4@28216|Betaproteobacteria,3T7IS@506|Alcaligenaceae	28216|Betaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_4231183_3	1216976.AX27061_2954	3.539e-102	343.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2VJVG@28216|Betaproteobacteria,3T1XS@506|Alcaligenaceae	28216|Betaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_4231183_4	1003200.AXXA_25525	6.118e-79	271.0	COG1173@1|root,COG1173@2|Bacteria,1MWP1@1224|Proteobacteria	1224|Proteobacteria	EP	(ABC) transporter, permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_4231183_1	1399774.JDWH01000030_gene2329	1.036e-157	509.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,1SMEC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_4231183_5	1379698.RBG1_1C00001G1240	2.438e-31	133.0	COG2239@1|root,COG2239@2|Bacteria,2NP79@2323|unclassified Bacteria	2|Bacteria	P	MgtE intracellular N domain	opuCA	-	3.6.3.32	ko:K02000,ko:K05847	ko02010,map02010	M00208,M00209	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	iSB619.SA_RS12845	ABC_tran,CBS,MgtE_N,PRC
HKD1_k127_4237691_33	671143.DAMO_0537	3.702e-12	66.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_4237691_23	671143.DAMO_0538	3.007e-46	169.0	COG0051@1|root,COG0051@2|Bacteria,2NPJY@2323|unclassified Bacteria	2|Bacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD1_k127_4237691_9	671143.DAMO_0539	1.804e-86	296.0	COG0087@1|root,COG0087@2|Bacteria,2NPAI@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010604,GO:0010628,GO:0015934,GO:0016020,GO:0016043,GO:0019219,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031325,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090069,GO:0090070,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000232,GO:2000234	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_4237691_17	1121423.JONT01000027_gene657	3.508e-56	203.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,248SY@186801|Clostridia,26186@186807|Peptococcaceae	186801|Clostridia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD1_k127_4237691_29	671143.DAMO_0541	3.991e-29	127.0	COG0089@1|root,COG0089@2|Bacteria,2NPWC@2323|unclassified Bacteria	2|Bacteria	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD1_k127_4237691_4	671143.DAMO_0542	8.663e-131	421.0	COG0090@1|root,COG0090@2|Bacteria,2NNR3@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_4237691_24	671143.DAMO_0543	7.893e-43	158.0	COG0185@1|root,COG0185@2|Bacteria,2NPIV@2323|unclassified Bacteria	2|Bacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD1_k127_4237691_28	671143.DAMO_0544	6.604e-35	137.0	COG0091@1|root,COG0091@2|Bacteria,2NPNW@2323|unclassified Bacteria	2|Bacteria	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005844,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042788,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD1_k127_4237691_6	671143.DAMO_0545	1.638e-101	335.0	COG0092@1|root,COG0092@2|Bacteria,2NP6J@2323|unclassified Bacteria	2|Bacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD1_k127_4237691_12	671143.DAMO_0546	8.595e-70	238.0	COG0197@1|root,COG0197@2|Bacteria,2NPC6@2323|unclassified Bacteria	2|Bacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD1_k127_4237691_36	742743.HMPREF9453_01315	7.837e-08	63.0	COG0255@1|root,COG0255@2|Bacteria,1VEME@1239|Firmicutes,4H5KY@909932|Negativicutes	909932|Negativicutes	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD1_k127_4237691_31	643648.Slip_2228	8.838e-24	103.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD1_k127_4237691_16	671143.DAMO_0549	4.127e-57	200.0	COG0093@1|root,COG0093@2|Bacteria,2NPCS@2323|unclassified Bacteria	2|Bacteria	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD1_k127_4237691_25	671143.DAMO_0550	5.905e-42	165.0	COG0198@1|root,COG0198@2|Bacteria,2NPT6@2323|unclassified Bacteria	2|Bacteria	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD1_k127_4237691_10	671143.DAMO_0551	6.517e-85	286.0	COG0094@1|root,COG0094@2|Bacteria,2NP65@2323|unclassified Bacteria	2|Bacteria	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD1_k127_4237691_30	671143.DAMO_0552	2.632e-28	114.0	COG0199@1|root,COG0199@2|Bacteria,2NPW7@2323|unclassified Bacteria	2|Bacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD1_k127_4237691_21	1449126.JQKL01000050_gene2688	8.927e-48	177.0	COG0096@1|root,COG0096@2|Bacteria,1V3KK@1239|Firmicutes,24HCP@186801|Clostridia,2696T@186813|unclassified Clostridiales	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD1_k127_4237691_13	671143.DAMO_0554	1.471e-69	240.0	COG0097@1|root,COG0097@2|Bacteria,2NPAS@2323|unclassified Bacteria	2|Bacteria	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD1_k127_4237691_27	1304284.L21TH_0908	4.632e-36	140.0	COG0256@1|root,COG0256@2|Bacteria,1V6DM@1239|Firmicutes,24JCS@186801|Clostridia,36JQ0@31979|Clostridiaceae	186801|Clostridia	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD1_k127_4237691_14	290397.Adeh_1929	2.812e-64	224.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,42QX0@68525|delta/epsilon subdivisions,2WNBN@28221|Deltaproteobacteria,2Z01M@29|Myxococcales	28221|Deltaproteobacteria	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD1_k127_4237691_35	671143.DAMO_0557	1.319e-10	71.0	COG1841@1|root,COG1841@2|Bacteria,2NQ1P@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L30	rpmD	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD1_k127_4237691_19	671143.DAMO_0558	6.872e-53	195.0	COG0200@1|root,COG0200@2|Bacteria,2NPNV@2323|unclassified Bacteria	2|Bacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD1_k127_4237691_1	1379698.RBG1_1C00001G1576	4.081e-164	537.0	COG0201@1|root,COG0201@2|Bacteria,2NNVK@2323|unclassified Bacteria	2|Bacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	GO:0002790,GO:0003674,GO:0005048,GO:0005215,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006605,GO:0006612,GO:0006613,GO:0006614,GO:0006616,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0031522,GO:0032940,GO:0032978,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034613,GO:0042277,GO:0042886,GO:0042887,GO:0043952,GO:0044425,GO:0044459,GO:0044464,GO:0045047,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061024,GO:0065002,GO:0070727,GO:0070972,GO:0071702,GO:0071705,GO:0071806,GO:0071840,GO:0071944,GO:0072594,GO:0072599,GO:0072657,GO:0090150,GO:1904680	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD1_k127_4237691_8	1125863.JAFN01000001_gene3315	1.606e-92	309.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,42M8E@68525|delta/epsilon subdivisions,2WJH0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	GO:0003674,GO:0003824,GO:0004017,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901576	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD1_k127_4237691_7	671143.DAMO_0561	5.954e-100	331.0	COG0024@1|root,COG0024@2|Bacteria,2NP57@2323|unclassified Bacteria	2|Bacteria	J	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_4237691_26	671143.DAMO_0562	3.38e-39	146.0	COG0361@1|root,COG0361@2|Bacteria,2NPNU@2323|unclassified Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_4237691_32	1280696.ATVY01000026_gene107	2.312e-15	76.0	COG0257@1|root,COG0257@2|Bacteria,1VK4F@1239|Firmicutes,24UGF@186801|Clostridia,4C0FI@830|Butyrivibrio	186801|Clostridia	J	Ribosomal protein L36	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD1_k127_4237691_18	1121468.AUBR01000044_gene1836	9.918e-55	196.0	COG0099@1|root,COG0099@2|Bacteria,1V3JH@1239|Firmicutes,24HCT@186801|Clostridia,42G97@68295|Thermoanaerobacterales	186801|Clostridia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_4237691_15	671143.DAMO_0564	6.665e-58	203.0	COG0100@1|root,COG0100@2|Bacteria,2NPCN@2323|unclassified Bacteria	2|Bacteria	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	GO:0000028,GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0048027,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD1_k127_4237691_11	671143.DAMO_0565	3.421e-78	274.0	COG0522@1|root,COG0522@2|Bacteria,2NPCC@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006417,GO:0006450,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010608,GO:0010628,GO:0015935,GO:0016020,GO:0019222,GO:0019843,GO:0030312,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032268,GO:0032270,GO:0032991,GO:0034248,GO:0034250,GO:0040007,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0045727,GO:0045903,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0060255,GO:0065007,GO:0065008,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1990904,GO:2000112	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD1_k127_4237691_2	671143.DAMO_0566	9.965e-164	520.0	COG0202@1|root,COG0202@2|Bacteria,2NNQQ@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	GO:0003674,GO:0003824,GO:0003899,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006354,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032774,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD1_k127_4237691_20	671143.DAMO_0567	1.627e-48	179.0	COG0203@1|root,COG0203@2|Bacteria,2NPYQ@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L17	rplQ	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02879,ko:K16193	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD1_k127_4237691_5	502558.EGYY_10820	2.82e-128	422.0	COG3875@1|root,COG3875@2|Bacteria,2I9JU@201174|Actinobacteria,4CVYU@84998|Coriobacteriia	84998|Coriobacteriia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_4237691_0	671143.DAMO_0568	3.005e-276	870.0	COG0480@1|root,COG0480@2|Bacteria,2NNQD@2323|unclassified Bacteria	2|Bacteria	J	elongation factor G	fusA-1	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_4237691_22	671143.DAMO_0569	8.41e-47	177.0	COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria	2|Bacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD1_k127_4237691_3	671143.DAMO_0571	3.029e-162	525.0	COG0195@1|root,COG0195@2|Bacteria,2NNV1@2323|unclassified Bacteria	2|Bacteria	K	Participates in both transcription termination and antitermination	nusA	GO:0001000,GO:0001121,GO:0001125,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0019904,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD1_k127_4237691_34	867903.ThesuDRAFT_00237	6.168e-11	72.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,3WCNN@538999|Clostridiales incertae sedis	186801|Clostridia	K	Protein of unknown function (DUF448)	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HKD1_k127_4240272_0	882086.SacxiDRAFT_4278	6.897e-15	89.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,2GMNT@201174|Actinobacteria,4DYP4@85010|Pseudonocardiales	201174|Actinobacteria	QU	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
HKD1_k127_424282_1	1184251.TCELL_0623	3.522e-37	144.0	COG0251@1|root,arCOG01630@2157|Archaea,2XQQW@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_424282_0	264732.Moth_2002	2.119e-53	201.0	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,42GF3@68295|Thermoanaerobacterales	186801|Clostridia	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3
HKD1_k127_424282_2	1449080.JQMV01000003_gene1325	2.76e-29	130.0	COG1752@1|root,COG1752@2|Bacteria,1WJFZ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_4254292_2	908340.HMPREF9406_1939	1.771e-21	94.0	COG0346@1|root,COG0346@2|Bacteria,1V235@1239|Firmicutes,24G5W@186801|Clostridia,36IEP@31979|Clostridiaceae	186801|Clostridia	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4254292_0	304371.MCP_2060	4.929e-41	164.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4254292_1	316274.Haur_1699	8.84e-41	158.0	COG4635@1|root,COG4635@2|Bacteria,2G739@200795|Chloroflexi,377J0@32061|Chloroflexia	32061|Chloroflexia	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD1_k127_4258541_3	869210.Marky_2238	4.273e-73	253.0	COG1173@1|root,COG1173@2|Bacteria,1WJC3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_4258541_2	869210.Marky_2239	4.368e-114	376.0	COG0601@1|root,COG0601@2|Bacteria,1WJIM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_4258541_0	869210.Marky_2240	8.555e-155	504.0	COG0747@1|root,COG0747@2|Bacteria,1WIYQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_4258541_4	1094980.Mpsy_1252	3.578e-25	109.0	COG0784@1|root,arCOG02594@2157|Archaea,2Y7NN@28890|Euryarchaeota,2NB1R@224756|Methanomicrobia	224756|Methanomicrobia	T	cheY-homologous receiver domain	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_24,Response_reg
HKD1_k127_4258541_1	671143.DAMO_2824	1.489e-123	409.0	COG1600@1|root,COG1600@2|Bacteria,2NNWV@2323|unclassified Bacteria	2|Bacteria	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006091,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009055,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0022900,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD1_k127_4271040_13	1382356.JQMP01000003_gene1514	6.379e-36	139.0	COG0730@1|root,COG0730@2|Bacteria,2G6ZH@200795|Chloroflexi,27Z7C@189775|Thermomicrobia	189775|Thermomicrobia	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_4271040_1	497964.CfE428DRAFT_6713	2.083e-219	693.0	COG3961@1|root,COG3961@2|Bacteria,46UYW@74201|Verrucomicrobia	74201|Verrucomicrobia	GH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_4271040_15	1206733.BAGC01000023_gene4653	9.918e-15	79.0	COG4244@1|root,COG4244@2|Bacteria,2II9W@201174|Actinobacteria,4G94C@85025|Nocardiaceae	201174|Actinobacteria	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD1_k127_4271040_17	1304275.C41B8_17069	1.879e-09	64.0	2EGDK@1|root,33A5G@2|Bacteria,1NIIK@1224|Proteobacteria,1SUBC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4271040_7	1159870.KB907784_gene2897	8.798e-116	386.0	COG1994@1|root,COG1994@2|Bacteria,1MY9R@1224|Proteobacteria	1224|Proteobacteria	K	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
HKD1_k127_4271040_10	1121405.dsmv_2783	1.301e-58	213.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2WMG9@28221|Deltaproteobacteria,2MJCA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890,ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HKD1_k127_4271040_11	1158292.JPOE01000005_gene772	7.743e-46	173.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,2VNGV@28216|Betaproteobacteria,1KP3Q@119065|unclassified Burkholderiales	28216|Betaproteobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4271040_0	580332.Slit_0161	2.088e-250	800.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VNZQ@28216|Betaproteobacteria	28216|Betaproteobacteria	P	ATPase (P-type)	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_4271040_3	945713.IALB_1306	3.952e-183	597.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD1_k127_4271040_4	941449.dsx2_1642	2.638e-181	585.0	COG4178@1|root,COG4178@2|Bacteria,1MW09@1224|Proteobacteria,43D2A@68525|delta/epsilon subdivisions,2WJNX@28221|Deltaproteobacteria,2MA4Z@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM ABC transporter	-	-	-	ko:K02471	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.203.11,3.A.1.203.4	-	-	ABC_membrane_2,ABC_tran
HKD1_k127_4271040_8	204669.Acid345_4575	1.013e-115	398.0	COG0842@1|root,COG1511@1|root,COG0842@2|Bacteria,COG1511@2|Bacteria,3Y65Z@57723|Acidobacteria,2JM5S@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_4271040_6	204669.Acid345_4576	3.142e-124	406.0	COG1131@1|root,COG1131@2|Bacteria,3Y3PY@57723|Acidobacteria,2JIQU@204432|Acidobacteriia	204432|Acidobacteriia	V	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4271040_12	204669.Acid345_4577	2.971e-41	166.0	COG1566@1|root,COG1566@2|Bacteria,3Y6U1@57723|Acidobacteria,2JKUF@204432|Acidobacteriia	204432|Acidobacteriia	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_4271040_5	1382356.JQMP01000003_gene2004	2.896e-154	503.0	COG1653@1|root,COG1653@2|Bacteria,2GBCK@200795|Chloroflexi,27Z27@189775|Thermomicrobia	189775|Thermomicrobia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_4271040_9	204669.Acid345_3004	1.897e-91	306.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria,2JHTD@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_4271040_2	1128421.JAGA01000003_gene2870	5.03e-219	694.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hmeA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
HKD1_k127_4278899_1	204669.Acid345_0152	1.117e-10	73.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria,2JISD@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8
HKD1_k127_4278899_0	1232410.KI421414_gene2883	6.134e-44	162.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,42M6W@68525|delta/epsilon subdivisions,2WIZF@28221|Deltaproteobacteria,43SZI@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_4280072_2	945713.IALB_2677	9.145e-15	76.0	2D6MI@1|root,32TMJ@2|Bacteria	2|Bacteria	S	PAP2 superfamily C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_C
HKD1_k127_4280072_0	357808.RoseRS_3952	7.265e-152	492.0	COG0477@1|root,COG0477@2|Bacteria,2GA6R@200795|Chloroflexi,3782R@32061|Chloroflexia	32061|Chloroflexia	EGP	major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_4280072_1	1121271.AUCM01000020_gene2803	1.715e-22	100.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_4283340_0	1380391.JIAS01000012_gene4191	1.392e-309	956.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2TSSN@28211|Alphaproteobacteria,2JUZY@204441|Rhodospirillales	204441|Rhodospirillales	E	Orn/Lys/Arg decarboxylase, N-terminal domain	-	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
HKD1_k127_4283340_1	1246459.KB898353_gene548	5.757e-116	376.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2U4SQ@28211|Alphaproteobacteria,4BC89@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Amino acid permease	potE	-	-	ko:K03756,ko:K03759	-	-	-	-	ko00000,ko02000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_4284343_0	1056820.KB900644_gene787	7.643e-154	505.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HKD1_k127_4312757_8	1125863.JAFN01000001_gene1637	1.383e-126	425.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,42NGG@68525|delta/epsilon subdivisions,2WIVT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_4312757_30	1131269.AQVV01000012_gene2625	4.554e-37	151.0	COG0739@1|root,COG0739@2|Bacteria	2|Bacteria	M	heme binding	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,Peptidase_M23
HKD1_k127_4312757_25	555079.Toce_0088	1.305e-47	181.0	COG0398@1|root,COG0398@2|Bacteria,1UHVT@1239|Firmicutes,24H7Q@186801|Clostridia	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_4312757_15	671143.DAMO_1570	1.107e-77	265.0	COG0639@1|root,COG0639@2|Bacteria,2NQ2C@2323|unclassified Bacteria	2|Bacteria	T	Calcineurin-like phosphoesterase	prp1	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
HKD1_k127_4312757_31	555088.DealDRAFT_1412	6.571e-37	152.0	COG2120@1|root,COG2120@2|Bacteria,1TUFP@1239|Firmicutes,25PKR@186801|Clostridia,42KY4@68298|Syntrophomonadaceae	186801|Clostridia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_4312757_4	1519464.HY22_09345	1.963e-150	489.0	COG1236@1|root,COG1236@2|Bacteria,1FER3@1090|Chlorobi	1090|Chlorobi	J	PFAM beta-lactamase domain protein	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HKD1_k127_4312757_5	401526.TcarDRAFT_0296	2.164e-146	475.0	COG0624@1|root,COG0624@2|Bacteria,1TQ0P@1239|Firmicutes,4H3RG@909932|Negativicutes	909932|Negativicutes	E	Amidase, hydantoinase carbamoylase family	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_4312757_13	671143.DAMO_3151	7.752e-79	269.0	COG0177@1|root,COG0177@2|Bacteria,2NP8N@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	GO:0000702,GO:0000703,GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006289,GO:0006296,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0033683,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.11.2,4.2.99.18	ko:K01142,ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_4312757_19	935839.JAGJ01000012_gene2934	1.148e-66	235.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4F49H@85017|Promicromonosporaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4312757_1	411464.DESPIG_02286	1.861e-199	638.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,42NMG@68525|delta/epsilon subdivisions,2WJIS@28221|Deltaproteobacteria,2M8EX@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM ABC transporter related	livG	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4312757_11	411464.DESPIG_02285	9.987e-114	374.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,42Z2M@68525|delta/epsilon subdivisions,2WTRP@28221|Deltaproteobacteria,2MGVY@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_4312757_7	411464.DESPIG_02288	1.969e-128	421.0	COG0683@1|root,COG0683@2|Bacteria,1MXR4@1224|Proteobacteria,42MXX@68525|delta/epsilon subdivisions,2WKJM@28221|Deltaproteobacteria,2M7W7@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	livK-1	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iAF987.Gmet_1823	Peripla_BP_6
HKD1_k127_4312757_20	671143.DAMO_0716	1.346e-65	239.0	COG1515@1|root,COG1515@2|Bacteria,2NPDB@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016788,GO:0016888,GO:0016893,GO:0034641,GO:0043170,GO:0043737,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
HKD1_k127_4312757_38	1174504.AJTN02000013_gene3851	1.645e-16	88.0	COG2318@1|root,COG2318@2|Bacteria,1V8A0@1239|Firmicutes,4HIW8@91061|Bacilli,1ZR7U@1386|Bacillus	91061|Bacilli	S	DinB superfamily	yuaE	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_4312757_27	861299.J421_2278	1.514e-46	177.0	COG4221@1|root,COG4221@2|Bacteria	2|Bacteria	IQ	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_4312757_6	671143.DAMO_1610	4.893e-144	467.0	COG3635@1|root,COG3635@2|Bacteria,2NP0Y@2323|unclassified Bacteria	2|Bacteria	G	2,3-bisphosphoglycerate-independent phosphoglycerate mutase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD1_k127_4312757_40	658086.HMPREF0994_05277	1.072e-13	77.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,24J9Z@186801|Clostridia,27PG8@186928|unclassified Lachnospiraceae	186801|Clostridia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_4312757_28	378806.STAUR_1216	8.008e-46	186.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42MZW@68525|delta/epsilon subdivisions,2WIV1@28221|Deltaproteobacteria,2YUVS@29|Myxococcales	28221|Deltaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PocR
HKD1_k127_4312757_14	526222.Desal_0985	4.596e-78	284.0	COG2114@1|root,COG2203@1|root,COG2114@2|Bacteria,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria	1224|Proteobacteria	T	GAF domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,HisKA_2,HisKA_3,PAS,PAS_3,PAS_4,PAS_9,Pkinase,STAS,SpoIIE
HKD1_k127_4312757_22	1499967.BAYZ01000147_gene719	1.205e-52	197.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	MA20_20705	-	3.4.21.107	ko:K04691,ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_4312757_9	671143.DAMO_1612	4.955e-126	413.0	COG0492@1|root,COG0492@2|Bacteria,2NNS7@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	GO:0000166,GO:0001666,GO:0003674,GO:0003824,GO:0004791,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0015035,GO:0015036,GO:0016209,GO:0016491,GO:0016651,GO:0016667,GO:0016668,GO:0019725,GO:0036094,GO:0036293,GO:0040007,GO:0042221,GO:0042592,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045454,GO:0048037,GO:0050660,GO:0050661,GO:0050662,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0055114,GO:0065007,GO:0065008,GO:0070402,GO:0070482,GO:0070887,GO:0097159,GO:0097237,GO:0098754,GO:0098869,GO:1901265,GO:1901363,GO:1990748	1.8.1.9,4.3.1.9	ko:K00384,ko:K03671,ko:K22345	ko00030,ko00450,ko04621,ko05418,map00030,map00450,map04621,map05418	-	R01544,R02016,R03596,R09372	RC00013,RC00544,RC02518,RC02873	ko00000,ko00001,ko01000,ko03110	-	-	iNJ661.Rv3913,iPC815.YPO1374	Pyr_redox_2
HKD1_k127_4312757_21	660470.Theba_2617	7.548e-61	226.0	COG2182@1|root,COG2182@2|Bacteria,2GD8M@200918|Thermotogae	200918|Thermotogae	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	-
HKD1_k127_4312757_16	1150474.JQJI01000019_gene1457	6.057e-76	277.0	COG1175@1|root,COG1175@2|Bacteria,2GC84@200918|Thermotogae	200918|Thermotogae	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_4312757_18	1040986.ATYO01000004_gene4892	7.914e-72	265.0	COG0395@1|root,COG0395@2|Bacteria,1MUWS@1224|Proteobacteria,2TS8M@28211|Alphaproteobacteria,43R1R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10190	ko02010,map02010	M00199,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.4	-	-	BPD_transp_1
HKD1_k127_4312757_12	3880.AES92405	2.754e-93	317.0	COG4692@1|root,2QTE2@2759|Eukaryota,37IW0@33090|Viridiplantae,3GCM2@35493|Streptophyta,4JD3J@91835|fabids	35493|Streptophyta	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD1_k127_4312757_42	335543.Sfum_3307	2.91e-07	52.0	COG0607@1|root,COG0607@2|Bacteria,1RA3A@1224|Proteobacteria,42QNH@68525|delta/epsilon subdivisions,2WMPB@28221|Deltaproteobacteria,2MRWM@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	MauE,Rhodanese
HKD1_k127_4312757_34	525897.Dbac_1677	6.024e-21	96.0	COG0607@1|root,COG0607@2|Bacteria,1RA3A@1224|Proteobacteria,42QNH@68525|delta/epsilon subdivisions,2WMPB@28221|Deltaproteobacteria,2MACC@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Rhodanese domain protein	-	-	-	-	-	-	-	-	-	-	-	-	MauE,Rhodanese
HKD1_k127_4312757_37	1168065.DOK_09429	3.904e-17	92.0	COG2931@1|root,COG4886@1|root,COG2931@2|Bacteria,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	inlA	-	3.4.24.40	ko:K01406,ko:K13730	ko01503,ko05100,map01503,map05100	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LRR_4,Strep_his_triad
HKD1_k127_4312757_43	394503.Ccel_0274	0.0009931	50.0	COG3693@1|root,COG4733@1|root,COG3693@2|Bacteria,COG4733@2|Bacteria,1TSZ3@1239|Firmicutes,24AU1@186801|Clostridia,36QSE@31979|Clostridiaceae	186801|Clostridia	G	Fibronectin, type III domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH,fn3
HKD1_k127_4312757_32	671143.DAMO_0140	8.012e-29	118.0	COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria	2|Bacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_4312757_36	880072.Desac_2588	2.704e-18	88.0	COG1826@1|root,COG1826@2|Bacteria,1QR6X@1224|Proteobacteria,433FU@68525|delta/epsilon subdivisions,2WXU4@28221|Deltaproteobacteria	2|Bacteria	U	Sec-independent protein translocase protein TatA	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_4312757_17	671143.DAMO_0882	1.471e-72	258.0	COG1028@1|root,COG1028@2|Bacteria,2NQVU@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD1_k127_4312757_39	457421.CBFG_01101	2.242e-16	89.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_4312757_0	237368.SCABRO_00651	2.55e-263	833.0	COG0417@1|root,COG0417@2|Bacteria	2|Bacteria	L	DNA replication proofreading	polB	-	2.7.7.7	ko:K02336,ko:K06877,ko:K07501	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	CarbopepD_reg_2,DNA_pol_B,DNA_pol_B_exo1,DNA_pol_B_exo2,RNase_H_2
HKD1_k127_4312757_23	1379698.RBG1_1C00001G0810	4.634e-52	195.0	COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria	2|Bacteria	S	Methyltransferase domain	yrrM	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD1_k127_4312757_26	479434.Sthe_1958	1.334e-46	177.0	COG0500@1|root,COG2226@2|Bacteria,2G6R0@200795|Chloroflexi,27Z68@189775|Thermomicrobia	189775|Thermomicrobia	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_4312757_24	443143.GM18_0716	7.281e-51	186.0	2CESE@1|root,32S0D@2|Bacteria,1RHTD@1224|Proteobacteria	1224|Proteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_OmpA
HKD1_k127_4312757_41	1504672.669786424	2.287e-10	70.0	2DRAW@1|root,33B0D@2|Bacteria,1QXFT@1224|Proteobacteria,2WI5J@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Type II secretion system protein B	-	-	-	-	-	-	-	-	-	-	-	-	T2SSB
HKD1_k127_4312757_2	671143.DAMO_0658	1.42e-176	569.0	COG3267@1|root,COG3409@1|root,COG3267@2|Bacteria,COG3409@2|Bacteria	2|Bacteria	M	Peptidoglycan-binding domain 1 protein	exeA	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0016020,GO:0044424,GO:0044464,GO:0071944	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HKD1_k127_4312757_3	1121423.JONT01000002_gene2185	9.717e-152	492.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,2600M@186807|Peptococcaceae	186801|Clostridia	C	PFAM Radical SAM	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_4312757_10	864051.BurJ1DRAFT_3978	5.405e-125	415.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,1KK5X@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4312757_29	671143.DAMO_0104	4.142e-39	161.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,TarH
HKD1_k127_4322959_1	4081.Solyc03g119300.2.1	9.099e-14	80.0	KOG1940@1|root,KOG1940@2759|Eukaryota,37INM@33090|Viridiplantae,3G8ZR@35493|Streptophyta,44MSP@71274|asterids	35493|Streptophyta	O	Hemerythrin HHE cation binding domain	-	-	-	ko:K16276	-	-	-	-	ko00000,ko04121	-	-	-	Hemerythrin,zf-CHY,zinc_ribbon_6
HKD1_k127_4323193_10	1288083.AUKR01000014_gene2879	0.0009201	45.0	COG0438@1|root,COG0438@2|Bacteria,2GJBP@201174|Actinobacteria	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Stealth_CR1,Stealth_CR2,Stealth_CR3
HKD1_k127_4323193_3	671143.DAMO_2998	2.503e-100	338.0	COG4974@1|root,COG4974@2|Bacteria,2NNN8@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	xerD	GO:0000150,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006276,GO:0006310,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008907,GO:0009009,GO:0009037,GO:0009314,GO:0009628,GO:0009987,GO:0015074,GO:0032991,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0048476,GO:0050896,GO:0071139,GO:0071704,GO:0090304,GO:0140097,GO:1901360	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_4323193_4	883.DvMF_0337	6.867e-91	310.0	COG0204@1|root,COG0204@2|Bacteria,1PY44@1224|Proteobacteria,42NR4@68525|delta/epsilon subdivisions,2WKKQ@28221|Deltaproteobacteria,2MAGC@213115|Desulfovibrionales	28221|Deltaproteobacteria	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_4323193_0	671143.DAMO_2988	1.063e-255	799.0	COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria	2|Bacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_4323193_1	999423.HMPREF9161_00546	9.45e-139	454.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,4H20Q@909932|Negativicutes	909932|Negativicutes	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_4323193_2	671143.DAMO_2986	5.583e-127	414.0	COG1494@1|root,COG1494@2|Bacteria,2NQE4@2323|unclassified Bacteria	2|Bacteria	G	Evidence 2b Function of strongly homologous gene	glpX	-	3.1.3.11,3.1.3.37	ko:K02446,ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD1_k127_4323193_8	118168.MC7420_659	1.059e-15	87.0	COG4191@1|root,COG4191@2|Bacteria,1FZY6@1117|Cyanobacteria,1HESU@1150|Oscillatoriales	1117|Cyanobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_4323193_7	671143.DAMO_1129	5.569e-22	104.0	COG0745@1|root,COG0745@2|Bacteria,2NPCK@2323|unclassified Bacteria	2|Bacteria	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4323193_5	1174528.JH992898_gene1079	1.11e-78	268.0	COG2135@1|root,COG2135@2|Bacteria,1G1SA@1117|Cyanobacteria,1JHC7@1189|Stigonemataceae	1117|Cyanobacteria	S	SOS response associated peptidase (SRAP)	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD1_k127_4323193_9	118173.KB235914_gene4248	4.717e-07	55.0	COG1357@1|root,COG2214@1|root,COG1357@2|Bacteria,COG2214@2|Bacteria,1G530@1117|Cyanobacteria,1H8Q1@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM Pentapeptide repeats (8 copies)	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,Pentapeptide
HKD1_k127_4323193_6	96561.Dole_1724	1.539e-63	226.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,42MWD@68525|delta/epsilon subdivisions,2WMG9@28221|Deltaproteobacteria,2MJCA@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Belongs to the BI1 family	ybhL	-	-	ko:K06890,ko:K19416	-	M00742	-	-	ko00000,ko00002,ko02000	1.A.14.2.1	-	-	Bax1-I
HKD1_k127_4356390_30	429009.Adeg_2060	3.285e-50	196.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,42F58@68295|Thermoanaerobacterales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD1_k127_4356390_0	671143.DAMO_1073	0.0	1216.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044464,GO:0071944	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_4356390_22	706587.Desti_4656	5.087e-76	263.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,42R5R@68525|delta/epsilon subdivisions,2WMRR@28221|Deltaproteobacteria,2MR65@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_4356390_23	1238182.C882_0518	3.718e-75	261.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2TR6T@28211|Alphaproteobacteria,2JQUS@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4356390_4	1125863.JAFN01000001_gene2468	6.731e-185	597.0	COG0559@1|root,COG4177@1|root,COG0559@2|Bacteria,COG4177@2|Bacteria,1MY1E@1224|Proteobacteria,42RIK@68525|delta/epsilon subdivisions,2WNDV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_4356390_10	1125863.JAFN01000001_gene2469	7.927e-128	421.0	COG0683@1|root,COG0683@2|Bacteria,1MWNB@1224|Proteobacteria,42TEX@68525|delta/epsilon subdivisions,2WPG8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_4356390_3	671143.DAMO_0001	7.214e-191	606.0	COG0593@1|root,COG0593@2|Bacteria,2NNTK@2323|unclassified Bacteria	2|Bacteria	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003688,GO:0003690,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010556,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043565,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:1990837,GO:2000112	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_4356390_36	671143.DAMO_0499	3.661e-35	151.0	COG1729@1|root,COG1729@2|Bacteria,2NQ0B@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6
HKD1_k127_4356390_6	671143.DAMO_0497	3.049e-150	490.0	COG0823@1|root,COG0823@2|Bacteria,2NNZC@2323|unclassified Bacteria	2|Bacteria	U	TolB amino-terminal domain	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019534,GO:0019904,GO:0022857,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1901998	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD1_k127_4356390_47	926566.Terro_2347	1.215e-05	56.0	COG0810@1|root,COG0810@2|Bacteria,3Y4WH@57723|Acidobacteria,2JJGH@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_2,TonB_C
HKD1_k127_4356390_31	671143.DAMO_0495	4.183e-50	181.0	COG0848@1|root,COG0848@2|Bacteria,2NQ52@2323|unclassified Bacteria	2|Bacteria	U	Biopolymer transport protein ExbD/TolR	tolR	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HKD1_k127_4356390_24	671143.DAMO_0494	4.803e-75	259.0	COG0811@1|root,COG0811@2|Bacteria,2NPFR@2323|unclassified Bacteria	2|Bacteria	U	MotA/TolQ/ExbB proton channel family	tolQ	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HKD1_k127_4356390_19	1379698.RBG1_1C00001G1766	5.13e-89	314.0	COG4365@1|root,COG4365@2|Bacteria,2NP8Q@2323|unclassified Bacteria	2|Bacteria	S	Bacillithiol biosynthesis BshC	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
HKD1_k127_4356390_9	1379698.RBG1_1C00001G1765	6.499e-129	422.0	COG0438@1|root,COG0438@2|Bacteria,2NNTN@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferases group 1	bshA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4356390_7	671143.DAMO_1044	1.008e-136	444.0	COG0761@1|root,COG0761@2|Bacteria,2NP7K@2323|unclassified Bacteria	2|Bacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4,2.7.4.25	ko:K00945,ko:K02945,ko:K03527	ko00240,ko00900,ko01100,ko01110,ko01130,ko03010,map00240,map00900,map01100,map01110,map01130,map03010	M00052,M00096,M00178	R00158,R00512,R01665,R05884,R08210	RC00002,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	iIT341.HP0400,iLJ478.TM1444	LYTB,S1
HKD1_k127_4356390_20	671143.DAMO_1512	2.746e-87	298.0	COG1562@1|root,COG1562@2|Bacteria,2NQ19@2323|unclassified Bacteria	2|Bacteria	I	Squalene/phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD1_k127_4356390_41	756067.MicvaDRAFT_4459	2.72e-31	134.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1GBCD@1117|Cyanobacteria,1HEX0@1150|Oscillatoriales	1117|Cyanobacteria	T	SMART Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
HKD1_k127_4356390_16	1499967.BAYZ01000123_gene2554	1.091e-97	331.0	COG0309@1|root,COG0309@2|Bacteria	2|Bacteria	O	Hydrogenase expression formation protein (HypE)	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_4356390_17	671143.DAMO_2078	5.181e-96	340.0	COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD1_k127_4356390_13	1382306.JNIM01000001_gene663	1.344e-115	403.0	COG2366@1|root,COG2366@2|Bacteria,2G63N@200795|Chloroflexi	200795|Chloroflexi	S	PFAM peptidase S45 penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD1_k127_4356390_43	944481.JAFP01000001_gene1083	4.304e-21	105.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,437DK@68525|delta/epsilon subdivisions,2WSN1@28221|Deltaproteobacteria,2M76S@213113|Desulfurellales	28221|Deltaproteobacteria	M	TonB C terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_4356390_32	1121924.ATWH01000014_gene3385	1.65e-45	178.0	COG0684@1|root,COG0684@2|Bacteria,2H979@201174|Actinobacteria	201174|Actinobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD1_k127_4356390_18	330214.NIDE1739	6.487e-92	318.0	COG0534@1|root,COG0534@2|Bacteria	2|Bacteria	V	drug transmembrane transporter activity	norM	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HKD1_k127_4356390_44	671143.DAMO_0828	5.476e-19	95.0	COG0457@1|root,COG0457@2|Bacteria	671143.DAMO_0828|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4356390_21	671143.DAMO_0003	1.48e-84	287.0	COG0785@1|root,COG0785@2|Bacteria,2NPE4@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD1_k127_4356390_35	545694.TREPR_0231	1.204e-36	147.0	COG0526@1|root,COG0526@2|Bacteria,2J8ET@203691|Spirochaetes	203691|Spirochaetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_4356390_42	671143.DAMO_0006	1.735e-21	108.0	COG1430@1|root,COG1430@2|Bacteria,2NQ88@2323|unclassified Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD1_k127_4356390_5	671143.DAMO_0007	4.487e-151	488.0	COG0265@1|root,COG0265@2|Bacteria,2NQPN@2323|unclassified Bacteria	2|Bacteria	O	Trypsin	degP	-	1.3.1.74	ko:K08070,ko:K08372	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_4356390_38	349161.Dred_0467	1.694e-33	147.0	COG0265@1|root,COG0265@2|Bacteria,1UYZJ@1239|Firmicutes,24JSN@186801|Clostridia	186801|Clostridia	O	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_4356390_26	1123371.ATXH01000045_gene1871	1.957e-63	236.0	28I4Y@1|root,2Z88D@2|Bacteria,2GI90@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4356390_37	589924.Ferp_0580	1.55e-34	141.0	COG1651@1|root,arCOG02868@2157|Archaea,2XW8R@28890|Euryarchaeota,246KW@183980|Archaeoglobi	183980|Archaeoglobi	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD1_k127_4356390_15	1125863.JAFN01000001_gene2253	3.78e-99	349.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4356390_1	1125863.JAFN01000001_gene1761	0.0	1025.0	COG1924@1|root,COG3580@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,1PKG6@1224|Proteobacteria,42MY4@68525|delta/epsilon subdivisions,2WJFI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	ATPase BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HKD1_k127_4356390_27	667014.Thein_1357	3.593e-62	240.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,2GGV4@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229
HKD1_k127_4356390_46	1120972.AUMH01000005_gene867	2.004e-06	59.0	COG1082@1|root,COG1082@2|Bacteria,1UZJZ@1239|Firmicutes	1239|Firmicutes	G	PFAM Xylose isomerase domain-containing protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_4356390_45	4555.Si034112m	4.28e-10	68.0	COG0111@1|root,KOG0067@2759|Eukaryota,37PFI@33090|Viridiplantae,3G8P1@35493|Streptophyta,3KMJY@4447|Liliopsida,3IEAD@38820|Poales	35493|Streptophyta	K	D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain	AN	GO:0000003,GO:0000226,GO:0000902,GO:0000904,GO:0003006,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005794,GO:0005802,GO:0005829,GO:0006950,GO:0006970,GO:0006996,GO:0007010,GO:0007017,GO:0007275,GO:0008150,GO:0008360,GO:0009628,GO:0009651,GO:0009653,GO:0009791,GO:0009826,GO:0009888,GO:0009908,GO:0009965,GO:0009987,GO:0010016,GO:0010026,GO:0010090,GO:0010091,GO:0010154,GO:0010482,GO:0010494,GO:0010769,GO:0012505,GO:0016043,GO:0016049,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0022613,GO:0022618,GO:0030154,GO:0030856,GO:0031128,GO:0031129,GO:0031984,GO:0032501,GO:0032502,GO:0032989,GO:0032991,GO:0034063,GO:0034622,GO:0035770,GO:0036464,GO:0040007,GO:0042802,GO:0042803,GO:0042814,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043933,GO:0044085,GO:0044422,GO:0044424,GO:0044431,GO:0044444,GO:0044446,GO:0044464,GO:0045595,GO:0045604,GO:0045682,GO:0046983,GO:0048366,GO:0048367,GO:0048437,GO:0048444,GO:0048468,GO:0048530,GO:0048589,GO:0048608,GO:0048731,GO:0048827,GO:0048831,GO:0048856,GO:0048869,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051128,GO:0051239,GO:0051302,GO:0060284,GO:0060560,GO:0061458,GO:0065003,GO:0065007,GO:0065008,GO:0070925,GO:0071826,GO:0071840,GO:0090558,GO:0090567,GO:0090626,GO:0090696,GO:0090697,GO:0090698,GO:0098791,GO:0099402,GO:1905392,GO:1990904,GO:2000024,GO:2000026,GO:2000039	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh_C
HKD1_k127_4356390_2	671143.DAMO_0036	3.953e-295	927.0	COG2217@1|root,COG2217@2|Bacteria,2NNPJ@2323|unclassified Bacteria	2|Bacteria	P	E1-E2 ATPase	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HKD1_k127_4356390_28	671143.DAMO_0035	2.916e-57	214.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	fixC	-	-	-	-	-	-	-	-	-	-	-	DAO,FAD_binding_3,NAD_binding_8,Pyr_redox_2,Trp_halogenase
HKD1_k127_4356390_40	671143.DAMO_0034	8.915e-32	130.0	COG1937@1|root,COG1937@2|Bacteria,2NQ1H@2323|unclassified Bacteria	2|Bacteria	S	Metal-sensitive transcriptional repressor	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD1_k127_4356390_8	1379698.RBG1_1C00001G0712	5.857e-136	449.0	COG0612@1|root,COG0612@2|Bacteria,2NQPM@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4356390_14	1379698.RBG1_1C00001G0711	1.484e-103	355.0	COG0612@1|root,COG0612@2|Bacteria,2NQHV@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	ymxG	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4356390_12	671143.DAMO_0702	4.978e-123	405.0	COG3424@1|root,COG3424@2|Bacteria,2NPHJ@2323|unclassified Bacteria	2|Bacteria	Q	Chalcone and stilbene synthases, C-terminal domain	bcsA	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	2.3.1.246	ko:K16424	ko01055,ko01130,map01055,map01130	-	R06625	RC00004,RC02933	ko00000,ko00001,ko01000	-	-	-	ACP_syn_III_C,Chal_sti_synt_C,Chal_sti_synt_N,FAE1_CUT1_RppA
HKD1_k127_4356390_29	671143.DAMO_0701	9.581e-51	195.0	COG0500@1|root,COG2226@2|Bacteria,2NRU8@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD1_k127_4356390_25	671143.DAMO_0700	2.674e-69	255.0	COG0644@1|root,COG0644@2|Bacteria,2NQ4F@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM geranylgeranyl reductase	fixC	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
HKD1_k127_4356390_34	246197.MXAN_3702	1.542e-37	147.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2WQKR@28221|Deltaproteobacteria,2YVE5@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_4356390_33	357808.RoseRS_3986	3.115e-39	158.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,375K6@32061|Chloroflexia	32061|Chloroflexia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HKD1_k127_4356390_11	192952.MM_1033	2.654e-124	424.0	COG0370@1|root,arCOG00359@2157|Archaea,2XU46@28890|Euryarchaeota,2N913@224756|Methanomicrobia	224756|Methanomicrobia	P	Ferrous iron transport B domain protein	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD1_k127_4356390_39	204669.Acid345_1870	9.199e-33	147.0	COG0672@1|root,COG0672@2|Bacteria,3Y3XB@57723|Acidobacteria,2JI3D@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM Iron permease FTR1	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318,FTR1
HKD1_k127_4362541_4	1499967.BAYZ01000073_gene2030	1.559e-100	334.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_4362541_3	338966.Ppro_0389	1.715e-102	343.0	COG1703@1|root,COG1703@2|Bacteria,1MVI0@1224|Proteobacteria,42NBN@68525|delta/epsilon subdivisions,2WK8A@28221|Deltaproteobacteria,43U0B@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD1_k127_4362541_0	391595.RLO149_c008600	1.358e-164	530.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2P4H9@2433|Roseobacter	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	MA20_17100	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_4362541_5	375451.RD1_3608	4.29e-36	144.0	COG3090@1|root,COG3090@2|Bacteria,1QXYB@1224|Proteobacteria,2TTWD@28211|Alphaproteobacteria,2P3YM@2433|Roseobacter	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_4362541_2	331869.BAL199_12441	1.757e-127	416.0	COG1638@1|root,COG1638@2|Bacteria,1MXUZ@1224|Proteobacteria,2TTTA@28211|Alphaproteobacteria,4BRM0@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_17110	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4362541_1	1121422.AUMW01000006_gene781	8.317e-143	469.0	COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,247ZG@186801|Clostridia,2617N@186807|Peptococcaceae	186801|Clostridia	I	Belongs to the 3-oxoacid CoA-transferase family	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_4362541_6	1068978.AMETH_3089	5.245e-13	71.0	COG4225@1|root,COG4225@2|Bacteria,2I2TJ@201174|Actinobacteria,4EDTA@85010|Pseudonocardiales	201174|Actinobacteria	S	Glycosyl Hydrolase Family 88	-	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
HKD1_k127_4376302_1	1278073.MYSTI_05459	4.404e-64	236.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
HKD1_k127_4376302_4	324925.Ppha_2429	7.863e-09	62.0	2EE3Q@1|root,337YA@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_4376302_5	1158760.AQXP01000048_gene1181	8.631e-09	57.0	2EPQB@1|root,33HAX@2|Bacteria,1NGGD@1224|Proteobacteria	1224|Proteobacteria	S	Putative addiction module component	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
HKD1_k127_4376302_3	525897.Dbac_1475	1.557e-23	109.0	COG1669@1|root,COG1669@2|Bacteria,1NABR@1224|Proteobacteria,42WE0@68525|delta/epsilon subdivisions,2WRWK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase beta domain protein region	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_4376302_2	383372.Rcas_3961	1.182e-34	138.0	COG2361@1|root,COG2361@2|Bacteria,2G8W4@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HKD1_k127_4376302_0	1195236.CTER_0964	1.614e-92	312.0	COG0246@1|root,COG0246@2|Bacteria,1TPZU@1239|Firmicutes,248J5@186801|Clostridia,3WGH9@541000|Ruminococcaceae	186801|Clostridia	C	Mannitol dehydrogenase	uxaB	-	1.1.1.17,1.1.1.58	ko:K00009,ko:K00041	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00631	R02555,R02703	RC00085	ko00000,ko00001,ko00002,ko01000	-	-	-	Mannitol_dh,Mannitol_dh_C
HKD1_k127_437635_7	402777.KB235904_gene4088	8.99e-97	328.0	COG0673@1|root,COG0673@2|Bacteria,1GEU5@1117|Cyanobacteria	1117|Cyanobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	ko:K18106	ko00040,ko01100,map00040,map01100	M00630	R07676,R10565	RC00108	ko00000,ko00001,ko00002,ko01000	-	-	-	GFO_IDH_MocA
HKD1_k127_437635_0	1382356.JQMP01000001_gene1155	4.852e-221	694.0	COG1350@1|root,COG1350@2|Bacteria,2G5YY@200795|Chloroflexi,27XSD@189775|Thermomicrobia	189775|Thermomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_437635_6	1499967.BAYZ01000167_gene6713	1.886e-106	355.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	afuA	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD1_k127_437635_1	1499967.BAYZ01000167_gene6712	3.061e-185	601.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	afuB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_437635_5	869210.Marky_2227	1.365e-112	379.0	COG3842@1|root,COG3842@2|Bacteria,1WIWM@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	fbpC	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD1_k127_437635_4	316274.Haur_2567	1.488e-117	394.0	COG1109@1|root,COG1109@2|Bacteria,2G5YP@200795|Chloroflexi,376E3@32061|Chloroflexia	32061|Chloroflexia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_437635_10	388467.A19Y_0973	1.147e-36	142.0	COG0662@1|root,COG0662@2|Bacteria,1G5UF@1117|Cyanobacteria,1HB1S@1150|Oscillatoriales	1117|Cyanobacteria	G	mannose-6-phosphate isomerase	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer
HKD1_k127_437635_8	373903.Hore_22860	5.182e-92	315.0	COG0836@1|root,COG0836@2|Bacteria,1TPC9@1239|Firmicutes,24908@186801|Clostridia,3WAC4@53433|Halanaerobiales	186801|Clostridia	M	PFAM Nucleotidyl transferase	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD1_k127_437635_2	1382356.JQMP01000004_gene206	8.903e-149	489.0	COG1089@1|root,COG1089@2|Bacteria,2G5P2@200795|Chloroflexi,27XFT@189775|Thermomicrobia	189775|Thermomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_437635_3	278963.ATWD01000002_gene630	2.909e-133	438.0	COG1004@1|root,COG1004@2|Bacteria,3Y3GR@57723|Acidobacteria,2JHU0@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_437635_9	671143.DAMO_2784	2.37e-55	205.0	COG0451@1|root,COG0451@2|Bacteria,2NP15@2323|unclassified Bacteria	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	rfbB	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_4382411_12	1121428.DESHY_110425___1	3.235e-53	193.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,267C6@186807|Peptococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4382411_3	1121405.dsmv_3093	6.748e-135	447.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,42Z5J@68525|delta/epsilon subdivisions,2X7Z6@28221|Deltaproteobacteria,2MMYR@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD1_k127_4382411_11	1232437.KL661969_gene4958	4.99e-57	219.0	COG5000@1|root,COG5000@2|Bacteria,1NU7E@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	zraS	-	2.7.13.3	ko:K02668,ko:K07709,ko:K07710	ko02020,map02020	M00499,M00500,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_9,sCache_3_2
HKD1_k127_4382411_7	671143.DAMO_2974	2.621e-90	309.0	COG0083@1|root,COG0083@2|Bacteria,2NPH7@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004413,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006566,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009088,GO:0009092,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019202,GO:0019752,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iECSE_1348.ECSE_0003,iJN678.thrB,iLJ478.TM0545,iSB619.SA_RS06620	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_4382411_8	404589.Anae109_1387	1.817e-81	281.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,42P7F@68525|delta/epsilon subdivisions,2WJW9@28221|Deltaproteobacteria,2YTWD@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0899	F420_oxidored,P5CR_dimer
HKD1_k127_4382411_15	1125863.JAFN01000001_gene2306	1.146e-33	133.0	COG0762@1|root,COG0762@2|Bacteria,1QDB9@1224|Proteobacteria,42VCU@68525|delta/epsilon subdivisions,2WRHX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD1_k127_4382411_18	290397.Adeh_1311	1.057e-21	101.0	COG3599@1|root,COG3599@2|Bacteria,1NCAV@1224|Proteobacteria,42VH6@68525|delta/epsilon subdivisions,2WS27@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM DivIVA family protein	-	-	-	ko:K04074	-	-	-	-	ko00000,ko03036	-	-	-	DivIVA
HKD1_k127_4382411_19	1121428.DESHY_50075___1	9.141e-17	89.0	COG1872@1|root,COG1872@2|Bacteria,1VFSH@1239|Firmicutes,24T87@186801|Clostridia,262RJ@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD1_k127_4382411_6	56780.SYN_03628	4.127e-113	371.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,42MEE@68525|delta/epsilon subdivisions,2WJYV@28221|Deltaproteobacteria,2MQ6Z@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_4382411_14	671143.DAMO_2765	2.148e-42	160.0	COG0789@1|root,COG0789@2|Bacteria,2NPTR@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator, MerR family	hspR	GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD1_k127_4382411_2	671143.DAMO_2767	3.273e-140	454.0	COG0484@1|root,COG0484@2|Bacteria,2NNSJ@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_4382411_10	671143.DAMO_2768	6.505e-60	210.0	COG0071@1|root,COG0071@2|Bacteria,2NPWF@2323|unclassified Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	hspA-1	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_4382411_0	671143.DAMO_2769	0.0	1029.0	COG0443@1|root,COG0443@2|Bacteria,2NNU1@2323|unclassified Bacteria	2|Bacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_4382411_5	243231.GSU0080	1.249e-113	378.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43T3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	degQ	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_4382411_16	751945.Theos_0487	1.199e-33	132.0	COG1324@1|root,COG1324@2|Bacteria,1WKG6@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	PFAM CutA1 divalent ion tolerance protein	cutA	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD1_k127_4382411_4	671143.DAMO_2771	2.247e-117	402.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,2NP1D@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	CP_0155	-	-	ko:K08307,ko:K12204	-	-	-	-	ko00000,ko01000,ko01011,ko02044	3.A.7.10.1,3.A.7.9.1	-	-	LysM,SLT,T4SS_TraI
HKD1_k127_4382411_13	768706.Desor_0960	1.133e-46	174.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,2626H@186807|Peptococcaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD1_k127_4382411_1	671143.DAMO_3000	2.627e-217	689.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_WbsX,RgpF
HKD1_k127_4382411_9	671143.DAMO_2999	2.696e-76	270.0	COG0438@1|root,COG0438@2|Bacteria,2NPWY@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase Family 4	recX	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006629,GO:0006643,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046467,GO:0046872,GO:0071704,GO:1901576	2.4.1.337	ko:K19002	ko00561,ko01100,map00561,map01100	-	R10850	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4385393_3	234267.Acid_4507	8.24e-143	460.0	COG0366@1|root,COG0366@2|Bacteria,3Y2P1@57723|Acidobacteria	57723|Acidobacteria	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD1_k127_4385393_6	335543.Sfum_0673	1.84e-18	98.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_4385393_5	671143.DAMO_3056	3.212e-76	261.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	lolD	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran
HKD1_k127_4385393_0	671143.DAMO_3055	1.618e-201	656.0	COG0577@1|root,COG4591@1|root,COG0577@2|Bacteria,COG4591@2|Bacteria,2NQQA@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	lolE-2	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_4385393_4	671143.DAMO_3054	1.088e-127	420.0	COG5621@1|root,COG5621@2|Bacteria,2NPFN@2323|unclassified Bacteria	2|Bacteria	S	Lipocalin-like domain	attH	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HKD1_k127_4385393_1	2711.XP_006494575.1	1.225e-192	608.0	COG0538@1|root,KOG1526@2759|Eukaryota,37IAT@33090|Viridiplantae,3GCE8@35493|Streptophyta	35493|Streptophyta	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_4385393_2	401526.TcarDRAFT_2265	2.081e-162	520.0	COG2828@1|root,COG2828@2|Bacteria,1TPP6@1239|Firmicutes,4H34Q@909932|Negativicutes	909932|Negativicutes	S	PrpF protein	-	-	-	-	-	-	-	-	-	-	-	-	PrpF
HKD1_k127_4385393_7	633148.Tagg_0018	4.218e-18	84.0	COG4739@1|root,arCOG04483@2157|Archaea,2XQGM@28889|Crenarchaeota	28889|Crenarchaeota	S	protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148
HKD1_k127_4399404_3	1123242.JH636435_gene2133	2.173e-11	66.0	COG2055@1|root,COG2055@2|Bacteria,2IZK5@203682|Planctomycetes	203682|Planctomycetes	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_4399404_1	251229.Chro_2067	1.733e-40	153.0	2AFDI@1|root,315DC@2|Bacteria,1GKYE@1117|Cyanobacteria,3VNDC@52604|Pleurocapsales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4399404_0	398767.Glov_2389	5.426e-65	231.0	COG0834@1|root,COG0834@2|Bacteria,1PEAV@1224|Proteobacteria,433AQ@68525|delta/epsilon subdivisions,2WY0A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_4399404_2	926550.CLDAP_10820	9.217e-21	99.0	COG3187@1|root,COG3187@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	Lipoprotein_21,META,YscW
HKD1_k127_4417514_7	9913.ENSBTAP00000006074	3.08e-07	53.0	2CMRF@1|root,2QRK8@2759|Eukaryota,38BZ6@33154|Opisthokonta,3BC6D@33208|Metazoa,3CRA6@33213|Bilateria,480TD@7711|Chordata,494JZ@7742|Vertebrata,3J3CH@40674|Mammalia,4J30Y@91561|Cetartiodactyla	33208|Metazoa	T	Cartilage oligomeric matrix protein	COMP	GO:0001501,GO:0001968,GO:0002020,GO:0003416,GO:0003417,GO:0003674,GO:0005198,GO:0005201,GO:0005488,GO:0005496,GO:0005499,GO:0005509,GO:0005515,GO:0005518,GO:0005539,GO:0005575,GO:0005576,GO:0005615,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005912,GO:0005924,GO:0005927,GO:0006950,GO:0007155,GO:0007275,GO:0007517,GO:0007610,GO:0008150,GO:0008201,GO:0008289,GO:0009653,GO:0009887,GO:0009888,GO:0009987,GO:0010941,GO:0012505,GO:0016043,GO:0016203,GO:0016528,GO:0016529,GO:0019842,GO:0019899,GO:0022610,GO:0030054,GO:0030055,GO:0030198,GO:0031012,GO:0032501,GO:0032502,GO:0032991,GO:0033554,GO:0033555,GO:0033627,GO:0034103,GO:0034976,GO:0035265,GO:0036094,GO:0040007,GO:0042981,GO:0043062,GO:0043066,GO:0043067,GO:0043069,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043394,GO:0043395,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0046872,GO:0048265,GO:0048266,GO:0048513,GO:0048519,GO:0048523,GO:0048589,GO:0048705,GO:0048731,GO:0048736,GO:0048856,GO:0050789,GO:0050794,GO:0050896,GO:0051216,GO:0051239,GO:0051716,GO:0060173,GO:0060348,GO:0060349,GO:0060350,GO:0060351,GO:0060538,GO:0060548,GO:0061061,GO:0061448,GO:0062023,GO:0065007,GO:0070161,GO:0071840,GO:0097159,GO:0097367,GO:0098868,GO:1901681	-	ko:K04659,ko:K16857	ko04015,ko04115,ko04145,ko04151,ko04350,ko04510,ko04512,ko05144,ko05165,ko05205,ko05206,ko05219,map04015,map04115,map04145,map04151,map04350,map04510,map04512,map05144,map05165,map05205,map05206,map05219	-	-	-	ko00000,ko00001,ko00536,ko04131,ko04147,ko04516	-	-	-	COMP,EGF_CA,TSP_3,TSP_C
HKD1_k127_4417514_2	1121918.ARWE01000001_gene2002	3.58e-81	287.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,43C4K@68525|delta/epsilon subdivisions,2X7F1@28221|Deltaproteobacteria,43TX3@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains HisKA, HATPase_c	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_4417514_0	1125863.JAFN01000001_gene1446	1.864e-164	533.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4417514_5	179408.Osc7112_0124	3.835e-17	92.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,1HA72@1150|Oscillatoriales	1117|Cyanobacteria	EG	PFAM EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4417514_6	1146883.BLASA_1780	2.06e-15	81.0	COG0745@1|root,COG2198@1|root,COG2199@1|root,COG0745@2|Bacteria,COG2198@2|Bacteria,COG3706@2|Bacteria	2|Bacteria	T	GGDEF domain	rcsD	GO:0000160,GO:0003674,GO:0003824,GO:0004672,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0009927,GO:0009987,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019538,GO:0023052,GO:0031224,GO:0031226,GO:0035556,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0060089,GO:0065007,GO:0071704,GO:0071944,GO:0140096,GO:1901564	2.7.13.3,2.7.7.65,4.6.1.1	ko:K01768,ko:K02488,ko:K07676,ko:K10715,ko:K20976	ko00230,ko02020,ko02024,ko02025,ko02026,ko04112,ko04113,ko04213,map00230,map02020,map02024,map02025,map02026,map04112,map04113,map04213	M00474,M00511,M00517,M00695,M00820	R00089,R00434,R08057	RC00295	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GGDEF,HATPase_c,HisKA,Hpt,RcsD_ABL,Response_reg,Trans_reg_C
HKD1_k127_4417514_4	118168.MC7420_5493	3.09e-26	114.0	COG4191@1|root,COG4191@2|Bacteria,1FZY6@1117|Cyanobacteria,1HESU@1150|Oscillatoriales	1117|Cyanobacteria	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_4417514_1	671143.DAMO_2595	2.061e-152	496.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4417514_3	113395.AXAI01000026_gene1886	2.742e-64	232.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TVM1@28211|Alphaproteobacteria,3JWG8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind
HKD1_k127_4418597_8	880072.Desac_1923	6.168e-18	83.0	COG2519@1|root,COG2519@2|Bacteria,1MXAK@1224|Proteobacteria,42NCI@68525|delta/epsilon subdivisions,2WJUH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_4418597_10	28072.Nos7524_4621	9.024e-13	79.0	COG0823@1|root,COG2304@1|root,COG3209@1|root,COG3210@1|root,COG0823@2|Bacteria,COG2304@2|Bacteria,COG3209@2|Bacteria,COG3210@2|Bacteria,1GQ0G@1117|Cyanobacteria,1HN8U@1161|Nostocales	1117|Cyanobacteria	MU	Dystroglycan-type cadherin-like domains.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,He_PIG,RHS_repeat
HKD1_k127_4418597_7	237368.SCABRO_03698	5.166e-24	109.0	2DQMK@1|root,337MR@2|Bacteria	2|Bacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_4418597_1	404589.Anae109_1050	9.819e-101	336.0	COG0604@1|root,COG0604@2|Bacteria,1PFUG@1224|Proteobacteria,43DPN@68525|delta/epsilon subdivisions,2X9UD@28221|Deltaproteobacteria,2Z058@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_4418597_9	909663.KI867150_gene2566	1.725e-16	90.0	COG0454@1|root,COG2159@1|root,COG0456@2|Bacteria,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,42PAQ@68525|delta/epsilon subdivisions,2WMYT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Amidohydrolase	bamU	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD1_k127_4418597_6	1330700.JQNC01000003_gene665	7.834e-27	114.0	COG2402@1|root,COG2402@2|Bacteria,1WJXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4418597_5	330214.NIDE0319	3.683e-64	228.0	COG0494@1|root,COG0494@2|Bacteria,3J0TN@40117|Nitrospirae	40117|Nitrospirae	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_4418597_0	670487.Ocepr_0886	5.44e-119	400.0	COG0737@1|root,COG0737@2|Bacteria,1WI46@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HKD1_k127_4418597_4	867845.KI911784_gene1019	7.454e-69	246.0	COG0524@1|root,COG0524@2|Bacteria,2G6JH@200795|Chloroflexi,376FG@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway	rbsK	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_4418597_3	485913.Krac_5802	1.89e-72	258.0	COG0673@1|root,COG0673@2|Bacteria,2G8YB@200795|Chloroflexi	200795|Chloroflexi	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_4418597_2	1499967.BAYZ01000068_gene1925	2.393e-82	287.0	COG0407@1|root,COG0407@2|Bacteria	1499967.BAYZ01000068_gene1925|-	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4418597_11	1192034.CAP_7115	2.493e-07	54.0	COG0240@1|root,COG0240@2|Bacteria	2|Bacteria	I	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD1_k127_4432643_1	583345.Mmol_0033	7.866e-65	224.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,2VPWE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4432643_0	1051632.TPY_0530	3.17e-101	346.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
HKD1_k127_4476572_2	880072.Desac_1511	2.513e-52	193.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42Q7R@68525|delta/epsilon subdivisions,2WQJC@28221|Deltaproteobacteria,2MRZG@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4476572_3	279714.FuraDRAFT_0229	1.189e-51	198.0	COG0438@1|root,COG0438@2|Bacteria,1MYJ6@1224|Proteobacteria,2VRG3@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4
HKD1_k127_4476572_0	344747.PM8797T_29887	1.295e-134	458.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_4476572_1	529507.PMI3161	1.425e-78	285.0	COG0438@1|root,COG0438@2|Bacteria,1MUTA@1224|Proteobacteria,1T844@1236|Gammaproteobacteria,3Z2B1@583|Proteus	1236|Gammaproteobacteria	M	Glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4482805_1	1232410.KI421426_gene1473	2.079e-58	209.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,42KZJ@68525|delta/epsilon subdivisions,2WJ4U@28221|Deltaproteobacteria,43TTP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	lactate/malate dehydrogenase, alpha/beta C-terminal domain	ldh	-	1.1.1.27,1.1.1.37	ko:K00016,ko:K00024	ko00010,ko00020,ko00270,ko00620,ko00630,ko00640,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04922,map00010,map00020,map00270,map00620,map00630,map00640,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200,map04922	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R00703,R01000,R03104,R07136	RC00031,RC00044	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_4482805_0	880072.Desac_0570	1.986e-151	486.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,42N30@68525|delta/epsilon subdivisions,2WJSW@28221|Deltaproteobacteria,2MQT1@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_4489034_1	1209989.TepiRe1_1970	3.947e-84	301.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,42FYW@68295|Thermoanaerobacterales	186801|Clostridia	G	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K11690	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctM
HKD1_k127_4489034_5	1504981.KO116_2426	1.343e-18	92.0	COG3090@1|root,COG3090@2|Bacteria,1N9UD@1224|Proteobacteria	1224|Proteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_4489034_3	375451.RD1_3609	1.507e-60	222.0	COG1638@1|root,COG1638@2|Bacteria,1MXUZ@1224|Proteobacteria,2TTTA@28211|Alphaproteobacteria,2P47R@2433|Roseobacter	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	MA20_17110	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4489034_0	1209989.TepiRe1_1967	3.403e-194	618.0	COG4670@1|root,COG4670@2|Bacteria,1TP5H@1239|Firmicutes,247ZG@186801|Clostridia,42FS5@68295|Thermoanaerobacterales	186801|Clostridia	I	Coenzyme A transferase	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_4489034_2	1354722.JQLS01000002_gene4565	7.179e-64	228.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,46QCV@74030|Roseovarius	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_4489034_4	1235799.C818_00850	4.076e-46	175.0	COG0673@1|root,COG0673@2|Bacteria,1V8V8@1239|Firmicutes,24PDR@186801|Clostridia	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_4491032_2	398767.Glov_2801	0.0008517	51.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	tonB3	-	-	ko:K03646,ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1,2.C.1.2	-	-	TonB_2,TonB_C
HKD1_k127_4491032_0	671143.DAMO_2966	1.017e-141	458.0	COG2876@1|root,COG2876@2|Bacteria,2NNPG@2323|unclassified Bacteria	2|Bacteria	E	PFAM DAHP synthetase I KDSA	aroG-2	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_4491032_1	671143.DAMO_2570	6.773e-52	190.0	COG0398@1|root,COG0398@2|Bacteria,2NRVF@2323|unclassified Bacteria	2|Bacteria	S	SNARE associated Golgi protein	yjbF	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_4499297_1	335543.Sfum_2414	1.207e-115	387.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_4499297_6	583355.Caka_1288	1.062e-07	60.0	2AG8J@1|root,316DU@2|Bacteria,46WFQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4499297_5	518766.Rmar_1709	6.802e-08	61.0	COG1309@1|root,COG1309@2|Bacteria,4NPAQ@976|Bacteroidetes,1FJF4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	WHG domain	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD1_k127_4499297_4	1267534.KB906754_gene3312	8.403e-64	237.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_4499297_3	1267534.KB906754_gene3313	1.288e-72	261.0	COG0845@1|root,COG0845@2|Bacteria,3Y8NI@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_4499297_0	1267534.KB906754_gene3314	0.0	1668.0	COG0841@1|root,COG0841@2|Bacteria	2|Bacteria	V	transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_4499297_2	1300345.LF41_901	3.118e-94	334.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_4502759_7	760568.Desku_1945	3.154e-22	98.0	COG2929@1|root,COG2929@2|Bacteria,1VPIJ@1239|Firmicutes,2520T@186801|Clostridia	186801|Clostridia	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD1_k127_4502759_8	1121430.JMLG01000011_gene329	1.109e-08	64.0	COG5304@1|root,COG5304@2|Bacteria,1VK0G@1239|Firmicutes,251YC@186801|Clostridia	186801|Clostridia	S	CopG antitoxin of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	CopG_antitoxin
HKD1_k127_4502759_1	880073.Calab_1713	5.133e-196	623.0	COG1660@1|root,COG3178@1|root,COG1660@2|Bacteria,COG3178@2|Bacteria,2NP9G@2323|unclassified Bacteria	2|Bacteria	S	P-loop ATPase protein family	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K06958,ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03019	-	-	-	APH,ATP_bind_2
HKD1_k127_4502759_5	204669.Acid345_3938	1.483e-67	241.0	COG1208@1|root,COG1208@2|Bacteria,3Y4HJ@57723|Acidobacteria	57723|Acidobacteria	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
HKD1_k127_4502759_4	1449976.KALB_5658	3.902e-96	329.0	COG0624@1|root,COG0624@2|Bacteria,2I8IJ@201174|Actinobacteria,4E62V@85010|Pseudonocardiales	201174|Actinobacteria	E	Peptidase dimerisation domain	-	-	3.5.1.18	ko:K01439,ko:K05831	ko00220,ko00300,ko01100,ko01120,ko01210,ko01230,map00220,map00300,map01100,map01120,map01210,map01230	M00016,M00031,M00763	R02734,R09779,R10933	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_4502759_3	273068.TTE0267	3.478e-106	355.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,25J0X@186801|Clostridia,42F6Z@68295|Thermoanaerobacterales	186801|Clostridia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_4502759_6	1296990.H845_832	5.055e-60	217.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2TT6C@28211|Alphaproteobacteria,2JS3E@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_4502759_0	1303518.CCALI_01287	0.0	1016.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K00162,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_4502759_2	671143.DAMO_2558	4.972e-183	586.0	COG0297@1|root,COG0297@2|Bacteria,2NP1F@2323|unclassified Bacteria	2|Bacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_4516597_5	1267533.KB906745_gene56	3.566e-168	531.0	COG0021@1|root,COG0021@2|Bacteria,3Y38K@57723|Acidobacteria,2JHWX@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_4516597_7	886293.Sinac_2019	3.132e-57	203.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_4516597_9	314230.DSM3645_29316	3.085e-13	70.0	COG3588@1|root,COG3588@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HKD1_k127_4516597_4	335283.Neut_2089	2.151e-179	567.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,371UZ@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_4516597_3	344747.PM8797T_23029	5.229e-229	720.0	COG1640@1|root,COG1640@2|Bacteria,2IXJJ@203682|Planctomycetes	203682|Planctomycetes	G	4-alpha-glucanotransferase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD1_k127_4516597_2	1187851.A33M_3475	1.432e-263	821.0	COG0033@1|root,COG0033@2|Bacteria,1MU5S@1224|Proteobacteria,2TRUJ@28211|Alphaproteobacteria,3FDI8@34008|Rhodovulum	28211|Alphaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_4516597_1	420324.KI912022_gene340	0.0	1339.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2TRER@28211|Alphaproteobacteria,1JT1D@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_4516597_0	743299.Acife_0337	0.0	1471.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,1RPSW@1236|Gammaproteobacteria,2NCTC@225057|Acidithiobacillales	225057|Acidithiobacillales	G	XFP C-terminal domain	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD1_k127_4516597_6	344747.PM8797T_23024	8.966e-79	268.0	COG0406@1|root,COG0406@2|Bacteria,2IZ7M@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD1_k127_4516597_8	414684.RC1_1895	1.525e-36	143.0	COG5490@1|root,COG5490@2|Bacteria,1MZ74@1224|Proteobacteria,2UCS0@28211|Alphaproteobacteria,2JTK7@204441|Rhodospirillales	204441|Rhodospirillales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD1_k127_4516597_10	1111479.AXAR01000003_gene1549	8.108e-11	62.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,4HA9Z@91061|Bacilli,279HI@186823|Alicyclobacillaceae	91061|Bacilli	C	Zinc-binding dehydrogenase	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_452238_10	326298.Suden_0065	4.905e-13	70.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,42N3P@68525|delta/epsilon subdivisions,2YM8F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_452238_6	234267.Acid_3629	4.823e-61	220.0	COG4221@1|root,COG4221@2|Bacteria,3Y79M@57723|Acidobacteria	57723|Acidobacteria	S	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_452238_9	351746.Pput_1890	2.064e-45	169.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S58P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	2Fe-2S -binding domain protein	-	GO:0003674,GO:0003824,GO:0006725,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016491,GO:0016725,GO:0019439,GO:0044237,GO:0044248,GO:0055114	1.17.2.1	ko:K18029	ko00760,ko01120,map00760,map01120	M00622	R09473	RC00589	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_452238_5	883.DvMF_2660	5.262e-62	225.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria,2M82B@213115|Desulfovibrionales	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
HKD1_k127_452238_1	1121405.dsmv_0407	1.813e-125	414.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2MHW4@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_452238_2	748247.AZKH_2914	2.35e-121	399.0	COG4257@1|root,COG4257@2|Bacteria,1QR8W@1224|Proteobacteria,2VMRR@28216|Betaproteobacteria	28216|Betaproteobacteria	V	Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HKD1_k127_452238_0	1267535.KB906767_gene4461	5.883e-145	466.0	COG0667@1|root,COG0667@2|Bacteria,3Y35T@57723|Acidobacteria,2JK73@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_452238_4	662479.C440_06512	2.621e-63	226.0	COG0819@1|root,arCOG01128@2157|Archaea,2XTG7@28890|Euryarchaeota,23STS@183963|Halobacteria	183963|Halobacteria	K	transcription activator	tenA	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
HKD1_k127_452238_12	472759.Nhal_0244	1.468e-07	62.0	2E5P1@1|root,330DP@2|Bacteria,1N794@1224|Proteobacteria,1SD5J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_452238_11	697282.Mettu_0807	7.954e-11	71.0	2E3EN@1|root,32YDN@2|Bacteria,1N7N7@1224|Proteobacteria,1SCSD@1236|Gammaproteobacteria,1XGTV@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HKD1_k127_452238_7	330214.NIDE3842	4.125e-49	176.0	COG3093@1|root,COG3093@2|Bacteria	2|Bacteria	K	addiction module antidote protein HigA	higA	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3,HTH_31
HKD1_k127_452238_8	330214.NIDE3841	1.188e-47	171.0	COG3549@1|root,COG3549@2|Bacteria	2|Bacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	higB	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HKD1_k127_452238_3	1437824.BN940_02996	5.558e-118	386.0	COG1715@1|root,COG1715@2|Bacteria,1Q2VY@1224|Proteobacteria,2VPK0@28216|Betaproteobacteria	28216|Betaproteobacteria	L	restriction endonuclease	-	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	Mrr_N,Mrr_cat
HKD1_k127_4527304_1	511051.CSE_12370	4.055e-36	140.0	COG0432@1|root,COG0432@2|Bacteria	2|Bacteria	S	Uncharacterised protein family UPF0047	yugU	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_4527304_2	215803.DB30_2742	4.407e-31	133.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,42URG@68525|delta/epsilon subdivisions,2WNDG@28221|Deltaproteobacteria,2YVX9@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	mceE	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_4527304_0	671143.DAMO_0052	3.638e-64	225.0	COG1586@1|root,COG1586@2|Bacteria,2NQ5D@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speH	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
HKD1_k127_4527314_2	671143.DAMO_0608	1.224e-60	214.0	COG2717@1|root,COG2717@2|Bacteria	2|Bacteria	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HKD1_k127_4527314_0	671143.DAMO_0609	5.734e-152	486.0	COG2041@1|root,COG2041@2|Bacteria,2NQ7J@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase molybdopterin binding domain	msrP	GO:0000302,GO:0001101,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0010035,GO:0016491,GO:0016667,GO:0016672,GO:0016675,GO:0019538,GO:0030091,GO:0030288,GO:0030313,GO:0031975,GO:0042221,GO:0042597,GO:0043170,GO:0043546,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0048037,GO:0050662,GO:0050896,GO:0055114,GO:0071704,GO:0097159,GO:1901363,GO:1901530,GO:1901564,GO:1901700	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HKD1_k127_4527314_3	269799.Gmet_3434	3.132e-59	217.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,42SE9@68525|delta/epsilon subdivisions,2WMQE@28221|Deltaproteobacteria,43TE9@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_4527314_1	335543.Sfum_3475	1.25e-145	481.0	COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MRDF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_4527314_5	398512.JQKC01000010_gene17	1.307e-08	60.0	2C477@1|root,32RDF@2|Bacteria	2|Bacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
HKD1_k127_4527314_4	404380.Gbem_1696	1.41e-33	134.0	COG1595@1|root,COG1595@2|Bacteria,1PEU8@1224|Proteobacteria,42T76@68525|delta/epsilon subdivisions,2WPVH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_453763_6	65497.JODV01000031_gene1297	8.147e-58	207.0	COG3333@1|root,COG3333@2|Bacteria,2ICF3@201174|Actinobacteria,4DXD5@85010|Pseudonocardiales	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD1_k127_453763_4	558169.AGAV01000018_gene3526	1.318e-107	359.0	COG3181@1|root,COG3181@2|Bacteria,1UY6C@1239|Firmicutes,4HERV@91061|Bacilli	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_453763_5	937777.Deipe_0046	1.323e-78	273.0	COG1940@1|root,COG1940@2|Bacteria,1WI42@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_453763_15	296591.Bpro_2062	0.000885	46.0	COG2807@1|root,COG2807@2|Bacteria,1QWE7@1224|Proteobacteria,2VRTI@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_453763_13	269799.Gmet_2048	1.991e-16	94.0	COG3005@1|root,COG3005@2|Bacteria,1NJY9@1224|Proteobacteria,42XJ4@68525|delta/epsilon subdivisions,2WSQ4@28221|Deltaproteobacteria,43TRS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	heme-binding sites	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_453763_2	204669.Acid345_2712	8.796e-141	471.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD1_k127_453763_7	234267.Acid_5653	3.595e-46	176.0	2EE9W@1|root,3384B@2|Bacteria	2|Bacteria	C	Menaquinol oxidoreductase complex Cbc4, cytochrome c subunit	cbcS	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Paired_CXXCH_1
HKD1_k127_453763_3	234267.Acid_5652	6.75e-108	360.0	COG0437@1|root,COG0437@2|Bacteria,3Y81X@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HKD1_k127_453763_1	234267.Acid_5651	7.131e-178	564.0	COG4881@1|root,COG4881@2|Bacteria	2|Bacteria	-	-	cbcU	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_453763_8	1267535.KB906767_gene185	5.16e-36	142.0	COG2259@1|root,COG2259@2|Bacteria,3Y4XF@57723|Acidobacteria,2JMZV@204432|Acidobacteriia	204432|Acidobacteriia	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_453763_11	479434.Sthe_2173	6.773e-27	123.0	COG0350@1|root,COG5662@1|root,COG0350@2|Bacteria,COG5662@2|Bacteria,2G98B@200795|Chloroflexi,27Z9T@189775|Thermomicrobia	2|Bacteria	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	cseE	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	zf-HC2
HKD1_k127_453763_9	479434.Sthe_2174	5.428e-30	126.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_453763_14	926550.CLDAP_01320	8.731e-16	88.0	COG2230@1|root,COG2230@2|Bacteria	2|Bacteria	M	cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574,ko:K03466	-	-	-	-	ko00000,ko01000,ko03036	3.A.12	-	-	DinB_2,Methyltransf_23,Methyltransf_25,Methyltransf_32
HKD1_k127_453763_12	1122919.KB905558_gene1272	5.095e-19	98.0	COG0622@1|root,COG0622@2|Bacteria	2|Bacteria	S	retrograde transport, endosome to Golgi	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	DinB_2,Metallophos_2
HKD1_k127_453763_0	563192.HMPREF0179_02740	1.335e-187	593.0	COG0078@1|root,COG0078@2|Bacteria,1N4DE@1224|Proteobacteria,42YM7@68525|delta/epsilon subdivisions,2WTZK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
HKD1_k127_453763_10	1304888.ATWF01000001_gene584	1.987e-28	115.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4543201_2	909663.KI867150_gene11	2.225e-129	424.0	COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,42QX9@68525|delta/epsilon subdivisions,2WKS8@28221|Deltaproteobacteria,2MRU4@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08224	-	-	-	-	ko00000,ko02000	2.A.1.36	-	-	MFS_1
HKD1_k127_4543201_3	1121468.AUBR01000001_gene575	8.015e-113	392.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,42EP9@68295|Thermoanaerobacterales	186801|Clostridia	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_4543201_0	86416.Clopa_4019	3.717e-203	658.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36EFE@31979|Clostridiaceae	186801|Clostridia	C	Glycine radical enzyme that catalyzes the cleavage of a C-N bond in choline, producing trimethylamine (TMA) and acetaldehyde	cutC	-	2.3.1.54,4.3.99.4	ko:K00656,ko:K20038	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_4543201_4	697281.Mahau_1338	4.183e-85	300.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,42J26@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S single cluster domain	yjjW	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_6,Radical_SAM
HKD1_k127_4543201_1	1169154.KB897778_gene3048	4.063e-137	448.0	COG1653@1|root,COG1653@2|Bacteria,2GJXB@201174|Actinobacteria	201174|Actinobacteria	G	ABC transporter substrate-binding protein	-	-	-	ko:K02027,ko:K10232	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_4543201_5	1122182.KB903837_gene3870	3.222e-41	156.0	COG1175@1|root,COG1175@2|Bacteria,2GKYS@201174|Actinobacteria,4DBI0@85008|Micromonosporales	201174|Actinobacteria	P	transport systems	aglF	-	-	ko:K02025,ko:K10233	ko02010,map02010	M00201,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.32,3.A.1.1.8	-	-	BPD_transp_1,CarboxypepD_reg
HKD1_k127_4544600_3	1123371.ATXH01000021_gene1114	7.025e-20	90.0	COG1418@1|root,COG1418@2|Bacteria,2GIAK@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_4544600_2	1220534.B655_0361	2.199e-25	123.0	arCOG07611@1|root,arCOG07611@2157|Archaea,2Y6AM@28890|Euryarchaeota,23PGQ@183925|Methanobacteria	183925|Methanobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD1_k127_4544600_1	1220534.B655_0361	1.613e-28	133.0	arCOG07611@1|root,arCOG07611@2157|Archaea,2Y6AM@28890|Euryarchaeota,23PGQ@183925|Methanobacteria	183925|Methanobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD1_k127_4544600_4	479431.Namu_2474	1.061e-06	62.0	COG0515@1|root,COG3391@1|root,COG0515@2|Bacteria,COG3391@2|Bacteria,2GNXG@201174|Actinobacteria,4EUTH@85013|Frankiales	201174|Actinobacteria	KLT	Lactonase, 7-bladed beta-propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Lactonase,Pkinase
HKD1_k127_4544600_0	697281.Mahau_0032	5.953e-100	335.0	COG0407@1|root,COG0407@2|Bacteria,1V5KX@1239|Firmicutes,24IAR@186801|Clostridia	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_4561495_1	1047013.AQSP01000130_gene1846	7.667e-18	87.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,PKD_2,Thioredoxin_7
HKD1_k127_4561495_0	1379698.RBG1_1C00001G0711	6.529e-75	264.0	COG0612@1|root,COG0612@2|Bacteria,2NQHV@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	ymxG	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4562624_0	518766.Rmar_0272	2.136e-257	809.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes,1FJXZ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	EU	Prolyl oligopeptidase family	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
HKD1_k127_4567815_10	795359.TOPB45_1248	1.954e-49	181.0	COG2204@1|root,COG2204@2|Bacteria,2GH05@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4567815_3	1121918.ARWE01000001_gene2941	3.349e-125	421.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MFH@68525|delta/epsilon subdivisions,2WIRW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_9,Sigma54_activat
HKD1_k127_4567815_7	926569.ANT_29430	1.199e-85	295.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_4567815_15	926569.ANT_29420	6.352e-24	106.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_4567815_17	768670.Calni_0464	6.994e-16	80.0	COG2768@1|root,COG2768@2|Bacteria	2|Bacteria	-	-	korD	-	1.2.7.3	ko:K00176,ko:K07138	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	DUF362,Fer4
HKD1_k127_4567815_2	1121468.AUBR01000007_gene242	2.846e-141	460.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,42FG2@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_4567815_5	316067.Geob_2667	5.192e-105	349.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria,43SWR@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM thiamine pyrophosphate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_4567815_9	443143.GM18_2783	7.144e-58	208.0	COG1014@1|root,COG1014@2|Bacteria,1RAQ4@1224|Proteobacteria,43BEE@68525|delta/epsilon subdivisions,2WN0D@28221|Deltaproteobacteria,43TV8@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_4567815_16	1387312.BAUS01000010_gene124	7.544e-21	97.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2VHSB@28216|Betaproteobacteria,2KKBW@206350|Nitrosomonadales	206350|Nitrosomonadales	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4567815_12	671143.DAMO_0983	8.364e-39	150.0	COG0589@1|root,COG0589@2|Bacteria,2NPUM@2323|unclassified Bacteria	2|Bacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4567815_14	222984.JNCS01000013_gene1450	1.163e-30	133.0	COG0589@1|root,arCOG00449@2157|Archaea,2XU1E@28890|Euryarchaeota,23TYX@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4567815_13	177437.HRM2_10670	1.337e-37	152.0	COG0489@1|root,COG0489@2|Bacteria,1R6AC@1224|Proteobacteria,42NTJ@68525|delta/epsilon subdivisions,2WM95@28221|Deltaproteobacteria,2MJ5Z@213118|Desulfobacterales	28221|Deltaproteobacteria	D	protein tyrosine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4567815_4	879212.DespoDRAFT_00108	1.95e-108	362.0	COG1013@1|root,COG1013@2|Bacteria,1N0HY@1224|Proteobacteria,42MTM@68525|delta/epsilon subdivisions,2WJS6@28221|Deltaproteobacteria,2MIRW@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_4567815_11	879212.DespoDRAFT_00109	2.016e-48	192.0	COG1014@1|root,COG1014@2|Bacteria,1R92Y@1224|Proteobacteria,42QJI@68525|delta/epsilon subdivisions,2WMFZ@28221|Deltaproteobacteria,2MJ4M@213118|Desulfobacterales	28221|Deltaproteobacteria	C	TIGRFAM 2-oxoacid acceptor oxidoreductase, gamma subunit, pyruvate 2-ketoisovalerate family	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_4567815_1	373903.Hore_06780	4.17e-146	472.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,3WBK2@53433|Halanaerobiales	186801|Clostridia	C	PFAM Pyruvate flavodoxin ferredoxin oxidoreductase	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_4567815_0	247490.KSU1_C0329	3.485e-244	772.0	COG1042@1|root,COG1042@2|Bacteria,2IXY9@203682|Planctomycetes	203682|Planctomycetes	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_4567815_8	247490.KSU1_C0330	1.543e-79	279.0	COG0857@1|root,COG0857@2|Bacteria,2J1B2@203682|Planctomycetes	203682|Planctomycetes	C	DRTGG domain	-	-	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,DRTGG,PTA_PTB
HKD1_k127_4567815_6	671143.DAMO_0898	1.223e-94	319.0	COG0382@1|root,COG0382@2|Bacteria,2NP4W@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_4593334_1	572547.Amico_1877	3.876e-90	308.0	COG1638@1|root,COG1638@2|Bacteria,3TC3K@508458|Synergistetes	508458|Synergistetes	G	transporter solute receptor, DctP family	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4593334_4	742741.HMPREF9475_00866	8.378e-17	87.0	COG3090@1|root,COG3090@2|Bacteria,1VAHP@1239|Firmicutes,24NMF@186801|Clostridia,2240N@1506553|Lachnoclostridium	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_4593334_0	1118054.CAGW01000050_gene1210	9.51e-143	473.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,26TTF@186822|Paenibacillaceae	91061|Bacilli	G	C4-dicarboxylate ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_4593334_3	56107.Cylst_0950	1.205e-17	98.0	2AYEV@1|root,31QI0@2|Bacteria,1G7E9@1117|Cyanobacteria	1117|Cyanobacteria	S	Domain of unknown function (DUF4178)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4178
HKD1_k127_4593334_2	316274.Haur_2857	3.037e-62	242.0	COG4262@1|root,COG4262@2|Bacteria	2|Bacteria	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HKD1_k127_4593334_5	1173022.Cri9333_4305	1.349e-15	87.0	COG2348@1|root,COG2348@2|Bacteria,1G1W5@1117|Cyanobacteria,1HESZ@1150|Oscillatoriales	1117|Cyanobacteria	V	FemAB family	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
HKD1_k127_461075_19	933262.AXAM01000070_gene2294	8.888e-19	93.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_461075_22	306263.Cla_0288	2.461e-05	49.0	COG2833@1|root,COG2833@2|Bacteria,1MW0V@1224|Proteobacteria,42KZ6@68525|delta/epsilon subdivisions,2YMPZ@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	hmm pf04305	-	-	-	-	-	-	-	-	-	-	-	-	DUF455
HKD1_k127_461075_20	1122138.AQUZ01000088_gene2349	2.472e-12	78.0	COG2378@1|root,COG2378@2|Bacteria,2GKFU@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,WYL
HKD1_k127_461075_13	671143.DAMO_3098	3.128e-43	168.0	COG2331@1|root,COG2331@2|Bacteria,2NRJX@2323|unclassified Bacteria	2|Bacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_461075_7	1041930.Mtc_1965	7.243e-87	305.0	COG1164@1|root,arCOG04758@2157|Archaea	2157|Archaea	E	oligoendopeptidase F	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
HKD1_k127_461075_0	243231.GSU0880	4.065e-299	932.0	COG0243@1|root,COG0243@2|Bacteria,1NR6J@1224|Proteobacteria,42MYN@68525|delta/epsilon subdivisions,2WIWN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_461075_14	671143.DAMO_2965	4.047e-41	156.0	COG0355@1|root,COG0355@2|Bacteria,2NPSQ@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01195,iJN746.PP_5412,iSbBS512_1146.SbBS512_E4190	ATP-synt_DE,ATP-synt_DE_N
HKD1_k127_461075_2	653733.Selin_2249	9.605e-221	692.0	COG0055@1|root,COG0055@2|Bacteria	2|Bacteria	C	proton-transporting ATP synthase activity, rotational mechanism	atpD	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	e_coli_core.b3732,iAF1260.b3732,iAPECO1_1312.APECO1_2729,iB21_1397.B21_03560,iBWG_1329.BWG_3423,iE2348C_1286.E2348C_4042,iEC042_1314.EC042_4119,iEC55989_1330.EC55989_4207,iECABU_c1320.ECABU_c42160,iECBD_1354.ECBD_4300,iECB_1328.ECB_03616,iECDH10B_1368.ECDH10B_3919,iECDH1ME8569_1439.ECDH1ME8569_3620,iECD_1391.ECD_03616,iECED1_1282.ECED1_4422,iECH74115_1262.ECH74115_5168,iECIAI1_1343.ECIAI1_3916,iECIAI39_1322.ECIAI39_4336,iECNA114_1301.ECNA114_3881,iECO103_1326.ECO103_4426,iECO111_1330.ECO111_4566,iECO26_1355.ECO26_4846,iECOK1_1307.ECOK1_4181,iECP_1309.ECP_3931,iECS88_1305.ECS88_4154,iECSE_1348.ECSE_4022,iECSF_1327.ECSF_3580,iECSP_1301.ECSP_4782,iECUMN_1333.ECUMN_4262,iECW_1372.ECW_m4035,iECs_1301.ECs4674,iEKO11_1354.EKO11_4613,iETEC_1333.ETEC_4023,iEcDH1_1363.EcDH1_4235,iEcE24377_1341.EcE24377A_4247,iEcSMS35_1347.EcSMS35_4100,iEcolC_1368.EcolC_4262,iG2583_1286.G2583_4528,iJO1366.b3732,iJR904.b3732,iLF82_1304.LF82_0194,iNRG857_1313.NRG857_18585,iPC815.YPO4121,iSFV_1184.SFV_3758,iSF_1195.SF3812,iSFxv_1172.SFxv_4154,iSSON_1240.SSON_3887,iS_1188.S3956,iSbBS512_1146.SbBS512_E4189,iUMN146_1321.UM146_18850,iUMNK88_1353.UMNK88_4544,iUTI89_1310.UTI89_C4285,iWFL_1372.ECW_m4035,iY75_1357.Y75_RS18410,iZ_1308.Z5230,ic_1306.c4658	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_461075_18	204669.Acid345_2164	2.688e-21	100.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_461075_6	671143.DAMO_2963	1.157e-103	348.0	COG0224@1|root,COG0224@2|Bacteria,2NP76@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030312,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0040007,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iLJ478.TM1611,iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
HKD1_k127_461075_1	671143.DAMO_2962	1.433e-266	827.0	COG0056@1|root,COG0056@2|Bacteria,2NP0S@2323|unclassified Bacteria	2|Bacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0016469,GO:0030312,GO:0032991,GO:0040007,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045259,GO:0045260,GO:0071944,GO:0098796,GO:0098797	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	iSB619.SA_RS10975	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD1_k127_461075_15	671143.DAMO_2961	6.002e-32	139.0	COG0712@1|root,COG0712@2|Bacteria,2NPV0@2323|unclassified Bacteria	2|Bacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD1_k127_461075_12	671143.DAMO_2960	3.422e-49	183.0	COG0711@1|root,COG0711@2|Bacteria,2NQ34@2323|unclassified Bacteria	2|Bacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01170,iYO844.BSU36850	ATP-synt_B
HKD1_k127_461075_10	82996.sch_12395	1.238e-73	273.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,1RPIE@1236|Gammaproteobacteria,4030R@613|Serratia	1236|Gammaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_461075_5	1123508.JH636441_gene3445	1.221e-117	389.0	COG0714@1|root,COG0714@2|Bacteria,2IY1M@203682|Planctomycetes	203682|Planctomycetes	S	ATPase associated with	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_461075_17	1173021.ALWA01000035_gene3770	4.412e-23	117.0	COG0457@1|root,COG0457@2|Bacteria,1G36K@1117|Cyanobacteria	1117|Cyanobacteria	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_10,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_461075_4	335541.Swol_1716	1.295e-149	527.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1TQXZ@1239|Firmicutes,249E6@186801|Clostridia	186801|Clostridia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	BatA,GATase1_like,VWA,VWA_2,VWA_3
HKD1_k127_461075_8	1303518.CCALI_01008	1.174e-80	307.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	mxaC	-	-	ko:K07114,ko:K16257	ko00680,ko01120,map00680,map01120	-	-	-	ko00000,ko00001,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_461075_9	502025.Hoch_3262	1.431e-77	269.0	COG1721@1|root,COG1721@2|Bacteria,1NEAC@1224|Proteobacteria,43B78@68525|delta/epsilon subdivisions,2X6KP@28221|Deltaproteobacteria,2YWA8@29|Myxococcales	28221|Deltaproteobacteria	S	Von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_461075_23	460265.Mnod_7089	0.0008041	47.0	291FC@1|root,2ZP26@2|Bacteria,1RF6N@1224|Proteobacteria,2U7T9@28211|Alphaproteobacteria,1JR9Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_461075_16	1304888.ATWF01000002_gene472	7.973e-25	113.0	COG1664@1|root,COG1664@2|Bacteria,2GFXX@200930|Deferribacteres	200930|Deferribacteres	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_461075_11	485915.Dret_0612	3.186e-56	220.0	COG0624@1|root,COG0624@2|Bacteria	2|Bacteria	E	succinyl-diaminopimelate desuccinylase activity	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_461075_3	497964.CfE428DRAFT_1536	1.036e-157	509.0	COG0160@1|root,COG0160@2|Bacteria,46UEH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_4626009_2	1117379.BABA_12815	1.518e-59	215.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H9PH@91061|Bacilli,1ZHG0@1386|Bacillus	91061|Bacilli	EH	Acetohydroxy acid isomeroreductase, NADPH-binding domain	serA3	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_4626009_0	1499967.BAYZ01000141_gene6143	3.019e-141	460.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	-	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006083,GO:0006091,GO:0006113,GO:0006520,GO:0006553,GO:0006554,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016054,GO:0016740,GO:0016769,GO:0016999,GO:0017144,GO:0019475,GO:0019477,GO:0019665,GO:0019666,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0036094,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0046440,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.6.1.111,5.4.3.8	ko:K01845,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_4626009_3	652103.Rpdx1_4362	2.258e-26	115.0	COG0251@1|root,COG0251@2|Bacteria,1RD6W@1224|Proteobacteria,2U8MG@28211|Alphaproteobacteria,3K1Y9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	rutC	-	-	ko:K09021	ko00240,ko01100,map00240,map01100	-	R09982	RC02768	ko00000,ko00001	-	-	-	Ribonuc_L-PSP
HKD1_k127_4626009_1	1380394.JADL01000001_gene2898	4.635e-130	422.0	COG1638@1|root,COG1638@2|Bacteria,1P6X1@1224|Proteobacteria,2TRTU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4626009_4	1297865.APJD01000005_gene3491	3.583e-09	63.0	COG3090@1|root,COG3090@2|Bacteria,1PR3S@1224|Proteobacteria,2U0AG@28211|Alphaproteobacteria,3JVM2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_4630903_6	671143.DAMO_2146	1.742e-129	430.0	COG0167@1|root,COG0167@2|Bacteria,2NNVA@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.14,1.3.5.2,1.3.98.1	ko:K00226,ko:K00254,ko:K02823,ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01867,R01868,R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15540	DHO_dh
HKD1_k127_4630903_12	96561.Dole_0627	8.672e-51	193.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,42RQK@68525|delta/epsilon subdivisions,2WNJU@28221|Deltaproteobacteria,2MKD4@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD1_k127_4630903_0	671143.DAMO_2142	0.0	1679.0	COG0458@1|root,COG0458@2|Bacteria,2NNPB@2323|unclassified Bacteria	2|Bacteria	EF	Carbamoyl-phosphate synthetase ammonia chain	carB	GO:0000050,GO:0000166,GO:0003674,GO:0003824,GO:0004087,GO:0004088,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016053,GO:0016597,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0071941,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0033,iBWG_1329.BWG_0031,iECDH10B_1368.ECDH10B_0034,iECDH1ME8569_1439.ECDH1ME8569_0031,iECUMN_1333.ECUMN_0034,iEcDH1_1363.EcDH1_3566,iJN746.PP_4723,iJO1366.b0033,iJR904.b0033,iPC815.YPO0482,iY75_1357.Y75_RS00170,iYL1228.KPN_00041	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_4630903_16	592015.HMPREF1705_01630	6.561e-26	111.0	COG2026@1|root,COG2026@2|Bacteria,3TCJI@508458|Synergistetes	508458|Synergistetes	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD1_k127_4630903_19	592015.HMPREF1705_01629	4.447e-17	82.0	2CD07@1|root,2ZQEB@2|Bacteria	2|Bacteria	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_4630903_2	671143.DAMO_2140	5.448e-178	567.0	COG0505@1|root,COG0505@2|Bacteria,2NNMS@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005951,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0019627,GO:0019752,GO:0032991,GO:0034641,GO:0040007,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1383	CPSase_sm_chain,GATase
HKD1_k127_4630903_3	671143.DAMO_2139	1.29e-174	572.0	COG0044@1|root,COG0044@2|Bacteria,2NNWP@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	GO:0003674,GO:0003824,GO:0004038,GO:0004151,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006144,GO:0006145,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016787,GO:0016810,GO:0016812,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046113,GO:0046390,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_4630903_5	671143.DAMO_2138	1.125e-143	473.0	COG0540@1|root,COG0540@2|Bacteria,2NNPZ@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the ATCase OTCase family	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00608,ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15490	OTCace,OTCace_N
HKD1_k127_4630903_10	671143.DAMO_2137	5.084e-76	265.0	COG2065@1|root,COG2065@2|Bacteria,2NPF2@2323|unclassified Bacteria	2|Bacteria	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	GO:0003674,GO:0003700,GO:0003824,GO:0004845,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006355,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031323,GO:0031326,GO:0034641,GO:0034654,GO:0043094,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0046390,GO:0046483,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0055086,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0080090,GO:0090407,GO:0140110,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
HKD1_k127_4630903_8	316274.Haur_0901	1.463e-86	302.0	COG1011@1|root,COG1011@2|Bacteria,2G916@200795|Chloroflexi,377HS@32061|Chloroflexia	32061|Chloroflexia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.8.1.2	ko:K01560,ko:K07025	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_4630903_7	867903.ThesuDRAFT_02355	9.385e-113	385.0	COG0421@1|root,COG0421@2|Bacteria,1UI4A@1239|Firmicutes,25GIE@186801|Clostridia	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD1_k127_4630903_9	671143.DAMO_2554	3.507e-81	284.0	COG0457@1|root,COG0457@2|Bacteria,2NQ8S@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4630903_11	264732.Moth_0883	7.942e-62	222.0	COG0284@1|root,COG0284@2|Bacteria,1TPPH@1239|Firmicutes,24DII@186801|Clostridia,42G12@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD1_k127_4630903_13	3218.PP1S25_361V6.1	2.947e-50	185.0	COG0461@1|root,KOG1377@2759|Eukaryota,37INB@33090|Viridiplantae,3GBYY@35493|Streptophyta	35493|Streptophyta	F	Uridine 5-monophosphate	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010035,GO:0010038,GO:0016036,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046686,GO:0050896,GO:0051716,GO:0071496	2.4.2.10,4.1.1.23	ko:K13421	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00051	R00965,R01870,R08231	RC00063,RC00409,RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,Pribosyltran
HKD1_k127_4630903_1	671143.DAMO_2552	1.523e-185	589.0	COG2256@1|root,COG2256@2|Bacteria,2NNTG@2323|unclassified Bacteria	2|Bacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_4630903_15	671143.DAMO_2562	1.634e-31	127.0	COG0776@1|root,COG0776@2|Bacteria,2NPTH@2323|unclassified Bacteria	2|Bacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530,ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_4630903_17	646529.Desaci_2258	6.683e-21	96.0	28ISQ@1|root,33DSE@2|Bacteria,1VQKR@1239|Firmicutes,24WZ0@186801|Clostridia,2662P@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4630903_14	1088721.NSU_4147	1.719e-35	145.0	COG0778@1|root,COG0778@2|Bacteria,1PG8V@1224|Proteobacteria,2U6HW@28211|Alphaproteobacteria,2KD5H@204457|Sphingomonadales	204457|Sphingomonadales	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4630903_4	671143.DAMO_0478	7.811e-151	522.0	COG2203@1|root,COG2770@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	vncS	-	2.1.1.80,2.7.13.3,3.1.1.61,3.1.3.3	ko:K07315,ko:K07641,ko:K10819,ko:K13924	ko02020,ko02030,map02020,map02030	M00449,M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035,ko03021	-	-	-	CheB_methylest,CheR,CheR_N,GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_10,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_4630903_20	1121403.AUCV01000073_gene1309	1.926e-16	94.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD1_k127_4650897_0	1047013.AQSP01000122_gene2249	3.222e-100	348.0	28NDD@1|root,2ZBG6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_4650897_1	1499967.BAYZ01000173_gene5812	4.619e-31	127.0	COG0484@1|root,COG0484@2|Bacteria,2NNNG@2323|unclassified Bacteria	2|Bacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_4686496_2	861299.J421_0340	1.319e-18	97.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
HKD1_k127_4686496_1	1123371.ATXH01000045_gene1871	7.07e-66	236.0	28I4Y@1|root,2Z88D@2|Bacteria,2GI90@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4686496_0	760192.Halhy_1631	7.013e-75	256.0	COG3191@1|root,COG3191@2|Bacteria,4NGDT@976|Bacteroidetes,1IR0G@117747|Sphingobacteriia	976|Bacteroidetes	EQ	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD1_k127_4694922_1	335543.Sfum_1603	9.213e-80	268.0	COG2344@1|root,COG2344@2|Bacteria,1R55V@1224|Proteobacteria,42M2S@68525|delta/epsilon subdivisions,2WM6N@28221|Deltaproteobacteria,2MQEC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HKD1_k127_4694922_0	1110502.TMO_1556	1.925e-214	676.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2JP8R@204441|Rhodospirillales	204441|Rhodospirillales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_471297_1	671143.DAMO_0756	5.345e-38	151.0	COG0477@1|root,COG2814@2|Bacteria,2NRCB@2323|unclassified Bacteria	2|Bacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_471297_2	378806.STAUR_7171	2.846e-09	68.0	28UXW@1|root,2ZH1P@2|Bacteria,1Q3E7@1224|Proteobacteria,43403@68525|delta/epsilon subdivisions,2X4CD@28221|Deltaproteobacteria,2YYR8@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_471297_0	909663.KI867150_gene1589	0.0	1043.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MQ80@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	TIGRFAM The (Largely Gram-negative Bacterial) Hydrophobe Amphiphile Efflux-1 (HAE1) Family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4734119_1	305700.B447_06722	1.046e-39	153.0	COG0697@1|root,COG0697@2|Bacteria,1R6KH@1224|Proteobacteria,2VNEM@28216|Betaproteobacteria,2KUC7@206389|Rhodocyclales	206389|Rhodocyclales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4734119_0	261292.Nit79A3_1589	9.196e-89	308.0	COG2211@1|root,COG2211@2|Bacteria,1NR4C@1224|Proteobacteria,2W1HW@28216|Betaproteobacteria	28216|Betaproteobacteria	G	MFS_1 like family	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4734119_2	909663.KI867150_gene2060	1.984e-26	119.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,42REH@68525|delta/epsilon subdivisions,2WP4D@28221|Deltaproteobacteria,2MQQW@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Hydrogenase maturation protease	hybD	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD1_k127_4734119_3	452637.Oter_3681	4.061e-23	108.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	hycI	GO:0003674,GO:0003824,GO:0004175,GO:0006464,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009987,GO:0010467,GO:0016485,GO:0016787,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.23.51	ko:K00442,ko:K03605,ko:K04656,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000,ko01002	-	-	iAF987.Gmet_3329	HycI
HKD1_k127_4734119_4	374847.Kcr_1119	7.307e-16	77.0	COG0374@1|root,arCOG01549@2157|Archaea	2157|Archaea	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	mvhA	-	1.12.1.2,1.8.98.5	ko:K00436,ko:K14126	ko00680,map00680	-	R00019,R00700,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_4739862_0	946483.Cenrod_1741	1.8e-155	499.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2VNF8@28216|Betaproteobacteria,4AG4P@80864|Comamonadaceae	28216|Betaproteobacteria	S	AAA domain	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HKD1_k127_4740603_3	861299.J421_2552	3.069e-25	110.0	COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_4740603_2	685727.REQ_43140	1.508e-52	199.0	COG1028@1|root,COG1028@2|Bacteria,2H0SM@201174|Actinobacteria,4G8MZ@85025|Nocardiaceae	201174|Actinobacteria	IQ	KR domain	-	-	1.1.1.100,1.1.1.401	ko:K00059,ko:K21883	ko00051,ko00061,ko00333,ko00780,ko01040,ko01100,ko01120,ko01130,ko01212,map00051,map00061,map00333,map00780,map01040,map01100,map01120,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11339,R11671	RC00029,RC00089,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD1_k127_4740603_1	443143.GM18_4330	1.742e-201	659.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,42MSV@68525|delta/epsilon subdivisions,2WJ6U@28221|Deltaproteobacteria,43URK@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Penicillin-Binding Protein C-terminus Family	pbp2	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HKD1_k127_4740603_0	29581.BW37_05092	0.0	1284.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2VI2R@28216|Betaproteobacteria,4730W@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1
HKD1_k127_47409_9	1347086.CCBA010000003_gene3874	3.919e-27	116.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H9PH@91061|Bacilli,1ZDB3@1386|Bacillus	91061|Bacilli	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA3	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_47409_6	292459.STH2228	8.044e-87	298.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,24HV2@186801|Clostridia	186801|Clostridia	S	PFAM Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_47409_2	292459.STH2229	1.444e-190	608.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,247UH@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_47409_14	204773.HEAR0349	4.449e-05	52.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria,475FX@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_47409_0	1121920.AUAU01000002_gene2129	0.0	1330.0	COG0247@1|root,COG0277@1|root,COG0479@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG0479@2|Bacteria,3Y2VH@57723|Acidobacteria	57723|Acidobacteria	C	FAD linked oxidases, C-terminal domain	-	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17
HKD1_k127_47409_7	1173028.ANKO01000220_gene584	1.9e-71	247.0	COG1556@1|root,COG1556@2|Bacteria	2|Bacteria	S	LUD domain	lldG	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HKD1_k127_47409_1	1173028.ANKO01000221_gene586	7.999e-211	668.0	COG1139@1|root,COG1139@2|Bacteria,1GC4K@1117|Cyanobacteria,1HF15@1150|Oscillatoriales	1117|Cyanobacteria	C	Pfam:DUF162	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_8,LUD_dom
HKD1_k127_47409_4	1173028.ANKO01000221_gene587	5.951e-113	370.0	COG0247@1|root,COG0247@2|Bacteria,1GCV7@1117|Cyanobacteria,1HFVC@1150|Oscillatoriales	1117|Cyanobacteria	C	Cysteine-rich domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HKD1_k127_47409_3	309801.trd_1427	7.56e-151	493.0	COG1914@1|root,COG1914@2|Bacteria,2GBWI@200795|Chloroflexi,27Z1D@189775|Thermomicrobia	189775|Thermomicrobia	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_47409_13	311424.DhcVS_1461	3.583e-09	63.0	COG4742@1|root,COG4742@2|Bacteria,2G9JQ@200795|Chloroflexi,34DHI@301297|Dehalococcoidia	301297|Dehalococcoidia	K	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_47409_5	1121472.AQWN01000004_gene823	3.532e-109	359.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,2635N@186807|Peptococcaceae	186801|Clostridia	O	C-terminal domain of 1-Cys peroxiredoxin	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA,Glyco_hydro_18
HKD1_k127_47409_12	1541960.KQ78_02283	1.258e-16	84.0	2E9JM@1|root,333SG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_47409_8	402777.KB235903_gene547	6.592e-34	132.0	2BXCR@1|root,2ZVFB@2|Bacteria,1GG9S@1117|Cyanobacteria,1HGNU@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_47409_10	1296990.H845_3457	7.887e-27	128.0	COG3012@1|root,COG3012@2|Bacteria,1NV40@1224|Proteobacteria,2U21K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_47409_11	1162668.LFE_1087	1.082e-16	95.0	COG0457@1|root,COG0653@1|root,COG1413@1|root,COG0457@2|Bacteria,COG0653@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	secA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0033220,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070,ko:K05385	ko00196,ko01100,ko02024,ko03060,ko03070,map00196,map01100,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko00194,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	HEAT_2,Helicase_C,NACHT,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_4752112_3	644283.Micau_6069	5.668e-25	111.0	COG1484@1|root,COG1484@2|Bacteria,2H714@201174|Actinobacteria,4DBWJ@85008|Micromonosporales	201174|Actinobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_4752112_1	338963.Pcar_1084	1.215e-88	303.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_4752112_2	909663.KI867150_gene35	5.044e-69	240.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,42QXP@68525|delta/epsilon subdivisions,2WP9I@28221|Deltaproteobacteria,2MRKK@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_4752112_4	1089553.Tph_c06620	2.434e-19	93.0	2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes,24SN5@186801|Clostridia,42HH1@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4752112_5	204669.Acid345_2821	1.281e-16	85.0	COG1125@1|root,COG1125@2|Bacteria,3Y7Q1@57723|Acidobacteria,2JMPH@204432|Acidobacteriia	204432|Acidobacteriia	E	ABC transporter	-	-	-	ko:K02068	-	M00211	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
HKD1_k127_4752112_6	1179773.BN6_23260	0.0001568	48.0	COG1136@1|root,COG1136@2|Bacteria,2GM25@201174|Actinobacteria,4DXSR@85010|Pseudonocardiales	201174|Actinobacteria	V	ABC-type antimicrobial peptide transport system, ATPase component	phnL	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4752112_0	573370.DMR_33550	1.787e-259	811.0	COG0043@1|root,COG0043@2|Bacteria,1MU62@1224|Proteobacteria,42MGF@68525|delta/epsilon subdivisions,2WJMB@28221|Deltaproteobacteria,2M9H9@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	PFAM Carboxylyase-related protein	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_4755979_0	1121861.KB899925_gene2507	6.043e-75	258.0	COG1052@1|root,COG1052@2|Bacteria,1QVZS@1224|Proteobacteria,2TUUQ@28211|Alphaproteobacteria,2JRNF@204441|Rhodospirillales	204441|Rhodospirillales	CH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_4755979_1	1121430.JMLG01000006_gene1704	2.58e-59	213.0	COG4887@1|root,COG4887@2|Bacteria,1V4ZU@1239|Firmicutes,24CCD@186801|Clostridia,260FV@186807|Peptococcaceae	186801|Clostridia	S	metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1847
HKD1_k127_4755979_3	1379698.RBG1_1C00001G0743	6.548e-47	174.0	COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria	2|Bacteria	S	DinB superfamily	dinB	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	DinB
HKD1_k127_4755979_5	580332.Slit_2809	1.54e-18	91.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,2VPWE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4755979_4	246194.CHY_0518	2.949e-42	167.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,24HZM@186801|Clostridia,42GAW@68295|Thermoanaerobacterales	186801|Clostridia	E	Acetolactate synthase, small subunit	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD1_k127_4755979_2	316274.Haur_4449	2.533e-48	176.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi,3751J@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_4770743_0	1121405.dsmv_0691	6.48e-99	331.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,42QDV@68525|delta/epsilon subdivisions,2WIRQ@28221|Deltaproteobacteria,2MN1S@213118|Desulfobacterales	68525|delta/epsilon subdivisions	L	PFAM transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_4770743_1	383372.Rcas_0194	2.39e-86	296.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_4798383_7	316067.Geob_3713	2.7e-35	147.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,42QXH@68525|delta/epsilon subdivisions,2WMN3@28221|Deltaproteobacteria,43TFD@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	SurA N-terminal domain	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HKD1_k127_4798383_4	864069.MicloDRAFT_00007850	4.336e-80	283.0	COG1820@1|root,COG1820@2|Bacteria,1MW8Y@1224|Proteobacteria,2TRBT@28211|Alphaproteobacteria,1JTPZ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,SIS_2
HKD1_k127_4798383_5	1382304.JNIL01000001_gene2454	2.666e-76	263.0	COG4821@1|root,COG4821@2|Bacteria,1TQS7@1239|Firmicutes,4HCR4@91061|Bacilli	91061|Bacilli	S	protein containing SIS (Sugar ISomerase) phosphosugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
HKD1_k127_4798383_3	1121085.AUCI01000001_gene3738	3.864e-90	308.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,4HD0U@91061|Bacilli,1ZCY6@1386|Bacillus	91061|Bacilli	G	COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4798383_1	1121085.AUCI01000001_gene3737	6.12e-129	428.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,1ZC02@1386|Bacillus	91061|Bacilli	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_4798383_8	1305836.AXVE01000011_gene1074	2.129e-13	83.0	COG3090@1|root,COG3090@2|Bacteria,1V9DU@1239|Firmicutes,4HJZX@91061|Bacilli,26FSK@186818|Planococcaceae	91061|Bacilli	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_4798383_2	273068.TTE0186	2.199e-96	326.0	COG1071@1|root,COG1071@2|Bacteria,1TQDG@1239|Firmicutes,249HX@186801|Clostridia,42ENM@68295|Thermoanaerobacterales	186801|Clostridia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_4798383_0	1178540.BA70_03890	1.563e-130	426.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,4HAP6@91061|Bacilli,1ZE4V@1386|Bacillus	91061|Bacilli	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	acoB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_4798383_6	622637.KE124774_gene461	3.855e-38	151.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD1_k127_482443_2	204669.Acid345_2176	4.869e-29	119.0	COG4274@1|root,COG4274@2|Bacteria,3Y8NH@57723|Acidobacteria,2JNFZ@204432|Acidobacteriia	204432|Acidobacteriia	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_482443_1	246197.MXAN_5096	8.338e-36	143.0	COG2311@1|root,COG2311@2|Bacteria,1RI24@1224|Proteobacteria,42ZYC@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Protein of unknown function (DUF418)	-	-	-	ko:K07148	-	-	-	-	ko00000	-	-	-	DUF418
HKD1_k127_482443_0	1173020.Cha6605_1913	4.165e-62	220.0	COG4320@1|root,COG4320@2|Bacteria,1G0BG@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD1_k127_4928913_4	545695.TREAZ_3666	2.374e-26	113.0	COG5611@1|root,COG5611@2|Bacteria	2|Bacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4928913_5	1121930.AQXG01000007_gene520	1.136e-06	53.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PrlF_antitoxin
HKD1_k127_4928913_3	1210884.HG799464_gene11111	1.041e-60	220.0	COG1402@1|root,COG1402@2|Bacteria,2IYP1@203682|Planctomycetes	203682|Planctomycetes	S	Creatinine amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Creatininase
HKD1_k127_4928913_0	1408254.T458_19905	2.668e-106	364.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4H9RG@91061|Bacilli	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_4928913_1	1408254.T458_19925	4.499e-93	316.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli	2|Bacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_4928913_2	479434.Sthe_0975	6.305e-69	244.0	COG1173@1|root,COG1173@2|Bacteria,2G6HB@200795|Chloroflexi	200795|Chloroflexi	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_4933780_5	113395.AXAI01000012_gene7132	2.287e-10	63.0	COG0475@1|root,COG0475@2|Bacteria,1R7K4@1224|Proteobacteria,2U29N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_4933780_4	926550.CLDAP_27670	1.557e-27	122.0	arCOG09854@1|root,3325R@2|Bacteria,2G7II@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4933780_1	706587.Desti_4722	4.527e-171	554.0	COG1966@1|root,COG1966@2|Bacteria,1MWF9@1224|Proteobacteria,42NBI@68525|delta/epsilon subdivisions,2WM33@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	carbon starvation protein CstA	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD1_k127_4933780_0	748280.NH8B_2300	7.012e-275	857.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2VHEV@28216|Betaproteobacteria,2KPHG@206351|Neisseriales	206351|Neisseriales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_4933780_2	42256.RradSPS_2804	9.355e-49	181.0	COG2862@1|root,COG2862@2|Bacteria	2|Bacteria	S	Uncharacterized protein family, UPF0114	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
HKD1_k127_4933780_3	335543.Sfum_1119	1.881e-33	132.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria,2MQVC@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Cation transporter/ATPase, N-terminus	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_4956482_0	684949.ATTJ01000001_gene2189	1.981e-109	357.0	COG4799@1|root,COG4799@2|Bacteria,1WI9K@1297|Deinococcus-Thermus	2|Bacteria	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD1_k127_4956482_1	292459.STH1479	1.428e-108	365.0	COG0624@1|root,COG0624@2|Bacteria,1TYR6@1239|Firmicutes,249CA@186801|Clostridia	186801|Clostridia	E	peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_4963203_8	744872.Spica_0418	7.533e-69	239.0	COG0517@1|root,COG0517@2|Bacteria,2J6JU@203691|Spirochaetes	203691|Spirochaetes	S	CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HKD1_k127_4963203_13	1502852.FG94_00985	1.039e-17	94.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2W8YT@28216|Betaproteobacteria,476D8@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,Response_reg
HKD1_k127_4963203_12	497964.CfE428DRAFT_3727	8.105e-20	95.0	2FH6M@1|root,34912@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
HKD1_k127_4963203_11	886293.Sinac_6207	3.102e-36	154.0	COG2234@1|root,COG2234@2|Bacteria,2IZ1R@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_4963203_3	261292.Nit79A3_1776	1.49e-107	359.0	COG2404@1|root,COG2404@2|Bacteria,1QWB5@1224|Proteobacteria,2VK0T@28216|Betaproteobacteria,374QT@32003|Nitrosomonadales	28216|Betaproteobacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4963203_0	187272.Mlg_2345	4.571e-222	706.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,1RME4@1236|Gammaproteobacteria,1WWRV@135613|Chromatiales	135613|Chromatiales	H	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysN	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU
HKD1_k127_4963203_2	593750.Metfor_0420	2.901e-130	422.0	COG0175@1|root,arCOG00073@2157|Archaea	2157|Archaea	C	Phosphoadenosine phosphosulfate reductase	-	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD1_k127_4963203_4	335543.Sfum_3525	2.696e-103	358.0	COG0446@1|root,COG0446@2|Bacteria,1QXXG@1224|Proteobacteria,42Z3E@68525|delta/epsilon subdivisions,2WU93@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_4963203_5	323261.Noc_1748	8.228e-85	295.0	COG0392@1|root,COG0392@2|Bacteria,1RCBH@1224|Proteobacteria,1S366@1236|Gammaproteobacteria,1X1IF@135613|Chromatiales	135613|Chromatiales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD1_k127_4963203_1	338963.Pcar_2083	8.25e-152	494.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,42MHH@68525|delta/epsilon subdivisions,2WIMW@28221|Deltaproteobacteria,43RZ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_4963203_6	671143.DAMO_2132	1.334e-84	290.0	COG1131@1|root,COG1131@2|Bacteria,2NP0I@2323|unclassified Bacteria	2|Bacteria	V	ATPases associated with a variety of cellular activities	ybhF-C	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_4963203_9	1123009.AUID01000007_gene717	7.918e-58	217.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,269C9@186813|unclassified Clostridiales	186801|Clostridia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_4963203_7	593117.TGAM_0604	6.772e-73	253.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MN@28890|Euryarchaeota,2431V@183968|Thermococci	183968|Thermococci	G	Function Code 14.4 Transport and Binding Proteins Carbohydrates, organic alcohols, and acids	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD1_k127_4963203_10	1144310.PMI07_004425	2.515e-49	180.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2U16Z@28211|Alphaproteobacteria,4BDVS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HKD1_k127_4980246_4	1033734.CAET01000027_gene914	4.06e-58	211.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,4HBWA@91061|Bacilli,1ZB42@1386|Bacillus	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	yflP	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_4980246_2	279714.FuraDRAFT_0377	2.577e-118	392.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VK0Q@28216|Betaproteobacteria,2KSD5@206351|Neisseriales	206351|Neisseriales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD1_k127_4980246_3	640512.BC1003_5557	1.93e-79	275.0	COG0745@1|root,COG0745@2|Bacteria,1R42P@1224|Proteobacteria,2VPC8@28216|Betaproteobacteria,1KGNM@119060|Burkholderiaceae	28216|Betaproteobacteria	K	response regulator	-	-	-	ko:K07774	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4980246_1	1095769.CAHF01000018_gene809	7.481e-140	462.0	COG0642@1|root,COG2205@2|Bacteria,1N1Z2@1224|Proteobacteria,2VITH@28216|Betaproteobacteria,473S3@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, His Kinase A (phosphoacceptor) domain, Two-component sensor kinase N-terminal	tctE	-	2.7.13.3	ko:K07649	ko02020,map02020	M00457	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	2CSK_N,HATPase_c,HisKA
HKD1_k127_4980246_0	1267535.KB906767_gene2436	2.584e-196	619.0	COG0578@1|root,COG0578@2|Bacteria,3Y2YF@57723|Acidobacteria,2JI40@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family	-	-	1.1.5.3	ko:K00111	ko00564,ko01110,map00564,map01110	-	R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD1_k127_4982848_0	196490.AUEZ01000129_gene1453	3.138e-147	475.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JX1Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD1_k127_4982848_1	1187851.A33M_1653	2.075e-39	148.0	COG2963@1|root,COG2963@2|Bacteria,1N8W3@1224|Proteobacteria,2UBXZ@28211|Alphaproteobacteria,3FEKX@34008|Rhodovulum	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD1_k127_4982848_2	1101189.AQUO01000001_gene3256	2.031e-12	69.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,2PX6A@265|Paracoccus	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
HKD1_k127_4986369_0	234267.Acid_1198	1.709e-126	418.0	COG1321@1|root,COG1321@2|Bacteria	2|Bacteria	K	iron dependent repressor	nagC	-	-	ko:K02003,ko:K02565,ko:K15545	-	M00258	-	-	ko00000,ko00002,ko02000,ko03000	3.A.1	-	-	HTH_IclR,MarR,ROK
HKD1_k127_5017209_2	1562701.BBOF01000050_gene1367	2.244e-42	160.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2VH6U@28216|Betaproteobacteria,1K5SV@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24,rve
HKD1_k127_5017209_1	640081.Dsui_1798	4.933e-95	317.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2VHN6@28216|Betaproteobacteria,2KW8C@206389|Rhodocyclales	206389|Rhodocyclales	L	PFAM IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_5017209_0	335543.Sfum_2619	1.141e-229	719.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,2MQBK@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
HKD1_k127_5030809_19	411902.CLOBOL_01808	2.312e-13	73.0	COG1063@1|root,COG1063@2|Bacteria,1UI0K@1239|Firmicutes,24ATX@186801|Clostridia,220EH@1506553|Lachnoclostridium	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5030809_5	742735.HMPREF9467_04543	5.43e-79	284.0	COG1064@1|root,COG1064@2|Bacteria,1TP5B@1239|Firmicutes,24GKF@186801|Clostridia	186801|Clostridia	C	TIGRFAM zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5030809_6	1385511.N783_18660	8.583e-70	247.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,2YBVV@289201|Pontibacillus	91061|Bacilli	U	Sugar ABC transporter permease	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5030809_10	373903.Hore_20620	2.543e-62	227.0	COG1175@1|root,COG1175@2|Bacteria,1TRC0@1239|Firmicutes,25C59@186801|Clostridia	186801|Clostridia	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5030809_11	660470.Theba_0502	2.871e-54	212.0	COG1653@1|root,COG1653@2|Bacteria,2GCR2@200918|Thermotogae	200918|Thermotogae	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_5030809_21	572478.Vdis_0684	1.507e-12	74.0	COG1917@1|root,arCOG02999@2157|Archaea	2157|Archaea	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5030809_8	479434.Sthe_2721	4.654e-65	228.0	COG2131@1|root,COG2131@2|Bacteria,2G7AC@200795|Chloroflexi	200795|Chloroflexi	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HKD1_k127_5030809_12	1123508.JH636452_gene7003	1.369e-53	192.0	COG0251@1|root,COG0251@2|Bacteria,2J0VA@203682|Planctomycetes	203682|Planctomycetes	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_5030809_7	1304885.AUEY01000090_gene2886	3.525e-69	240.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,42RB9@68525|delta/epsilon subdivisions,2WMPE@28221|Deltaproteobacteria,2MJPY@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Ferritin-like domain	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD1_k127_5030809_9	715226.ABI_45000	2.605e-64	237.0	28M8D@1|root,311HE@2|Bacteria,1RFC1@1224|Proteobacteria,2TZZT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
HKD1_k127_5030809_3	1341151.ASZU01000009_gene922	4.756e-108	364.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HDN8@91061|Bacilli,27C0D@186824|Thermoactinomycetaceae	91061|Bacilli	M	DegT/DnrJ/EryC1/StrS aminotransferase family	pseC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_5030809_4	234267.Acid_6623	4.632e-81	289.0	COG1032@1|root,COG1032@2|Bacteria,3Y34B@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_5030809_14	1210884.HG799463_gene9897	6.029e-40	160.0	COG0500@1|root,COG2226@2|Bacteria,2J51A@203682|Planctomycetes	203682|Planctomycetes	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_5030809_20	1313301.AUGC01000005_gene266	1.211e-12	78.0	COG1708@1|root,COG1708@2|Bacteria,4NPRU@976|Bacteroidetes	976|Bacteroidetes	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD1_k127_5030809_16	1220534.B655_2035	5.26e-30	131.0	COG0500@1|root,arCOG01773@2157|Archaea,2Y131@28890|Euryarchaeota	28890|Euryarchaeota	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_5030809_22	483219.LILAB_14385	3.386e-11	68.0	28UXW@1|root,2ZH1P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5030809_13	1094980.Mpsy_1597	3.823e-50	192.0	COG0500@1|root,arCOG01780@2157|Archaea	2157|Archaea	Q	COG0500 SAM-dependent methyltransferases	pcm3	-	-	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00609	R10404	RC00003	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_5030809_2	522306.CAP2UW1_3938	9.097e-124	409.0	COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,2VJQM@28216|Betaproteobacteria,1KQGX@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	Sodium/calcium exchanger protein	chaA	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HKD1_k127_5030809_1	96561.Dole_2247	1.341e-130	428.0	COG1149@1|root,COG1149@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	ldpA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,LdpA_C
HKD1_k127_5030809_15	743721.Psesu_2716	2.137e-36	149.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1X5ID@135614|Xanthomonadales	135614|Xanthomonadales	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_5030809_17	386456.JQKN01000008_gene1488	3.918e-21	94.0	arCOG03086@1|root,arCOG03086@2157|Archaea	2157|Archaea	S	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_5030809_18	113355.CM001775_gene2407	3.99e-17	85.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_5030809_0	1121422.AUMW01000031_gene3050	1.738e-166	535.0	COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1TSPA@1239|Firmicutes,248CT@186801|Clostridia,2633G@186807|Peptococcaceae	186801|Clostridia	L	DEAD DEAH box	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HKD1_k127_5032625_9	1118054.CAGW01000024_gene462	2.116e-93	315.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26VSD@186822|Paenibacillaceae	91061|Bacilli	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_5032625_8	1408254.T458_19925	4.156e-102	341.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli	2|Bacteria	P	COG0601 ABC-type dipeptide oligopeptide nickel transport systems, permease components	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_5032625_6	1118054.CAGW01000024_gene464	9.667e-108	369.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4H9RG@91061|Bacilli,26TM1@186822|Paenibacillaceae	91061|Bacilli	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_5032625_15	351160.RCIX906	9.375e-62	228.0	COG0624@1|root,arCOG01107@2157|Archaea,2XU86@28890|Euryarchaeota,2NB5W@224756|Methanomicrobia	224756|Methanomicrobia	E	peptidase dimerisation domain	argE	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5032625_12	42256.RradSPS_0871	1.241e-83	301.0	COG1478@1|root,COG1478@2|Bacteria,2GMJ8@201174|Actinobacteria,4CQ5F@84995|Rubrobacteria	84995|Rubrobacteria	C	F420-0:Gamma-glutamyl ligase	-	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HKD1_k127_5032625_10	1382306.JNIM01000001_gene1897	2.824e-93	316.0	COG0391@1|root,COG0391@2|Bacteria,2G5S2@200795|Chloroflexi	200795|Chloroflexi	S	TIGRFAM LPPG domain protein containing protein	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HKD1_k127_5032625_17	13690.CP98_02511	4.692e-54	199.0	COG2085@1|root,COG2085@2|Bacteria,1MXS0@1224|Proteobacteria,2TS1W@28211|Alphaproteobacteria,2K27G@204457|Sphingomonadales	204457|Sphingomonadales	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD1_k127_5032625_3	1382356.JQMP01000001_gene1157	8.875e-118	391.0	COG1060@1|root,COG1060@2|Bacteria,2GBD4@200795|Chloroflexi,27YV4@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_5032625_2	309801.trd_A0900	6.366e-127	419.0	COG1060@1|root,COG1060@2|Bacteria,2G7YI@200795|Chloroflexi,27YSR@189775|Thermomicrobia	189775|Thermomicrobia	H	Elongator protein 3, MiaB family, Radical SAM	-	-	2.5.1.77	ko:K11779	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_5032625_19	1168289.AJKI01000031_gene1103	4.83e-48	179.0	COG2431@1|root,COG2431@2|Bacteria,4NMM0@976|Bacteroidetes,2FNT2@200643|Bacteroidia,3XK66@558415|Marinilabiliaceae	976|Bacteroidetes	S	Lysine exporter LysO	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
HKD1_k127_5032625_23	880526.KE386488_gene835	1.996e-07	56.0	COG2431@1|root,COG2431@2|Bacteria,4NMM0@976|Bacteroidetes,2FNT2@200643|Bacteroidia,22UHB@171550|Rikenellaceae	976|Bacteroidetes	S	Lysine exporter LysO	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
HKD1_k127_5032625_13	357808.RoseRS_3986	1.956e-73	254.0	COG1321@1|root,COG1918@1|root,COG1321@2|Bacteria,COG1918@2|Bacteria,2G6N4@200795|Chloroflexi,375K6@32061|Chloroflexia	32061|Chloroflexia	K	iron dependent repressor	-	-	-	ko:K03709	-	-	-	-	ko00000,ko03000	-	-	-	Fe_dep_repr_C,Fe_dep_repress,FeoA
HKD1_k127_5032625_1	552811.Dehly_0458	9.956e-130	423.0	COG0685@1|root,COG0685@2|Bacteria	2|Bacteria	E	methylenetetrahydrofolate reductase (NAD(P)H) activity	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD1_k127_5032625_16	1382356.JQMP01000001_gene1054	1.446e-60	218.0	COG1028@1|root,COG1028@2|Bacteria,2G6SC@200795|Chloroflexi,27YY5@189775|Thermomicrobia	189775|Thermomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_5032625_18	1499967.BAYZ01000089_gene5042	9.825e-50	181.0	COG2030@1|root,COG2030@2|Bacteria,2NRNG@2323|unclassified Bacteria	2|Bacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_5032625_0	94624.Bpet3948	6.624e-134	435.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,2VMPR@28216|Betaproteobacteria,3T6V0@506|Alcaligenaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES-like domain	idnD	-	1.1.1.264	ko:K00098	-	-	R05684	RC00089	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5032625_7	247490.KSU1_D0148	1.604e-105	352.0	COG1723@1|root,COG1723@2|Bacteria,2J0AJ@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5032625_20	1187851.A33M_3396	9.248e-43	160.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
HKD1_k127_5032625_22	309807.SRU_0964	8.637e-14	76.0	COG2127@1|root,COG2127@2|Bacteria,4PERZ@976|Bacteroidetes,1FJHS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	ATP-dependent Clp protease adaptor protein ClpS	-	-	-	-	-	-	-	-	-	-	-	-	ClpS
HKD1_k127_5032625_14	1396141.BATP01000003_gene5111	1.889e-62	230.0	COG0745@1|root,COG1235@1|root,COG2203@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,COG2203@2|Bacteria,46UKB@74201|Verrucomicrobia,2IVU2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Response_reg
HKD1_k127_5032625_21	573413.Spirs_1697	1.308e-19	102.0	COG0745@1|root,COG0745@2|Bacteria,2J7CK@203691|Spirochaetes	203691|Spirochaetes	K	COGs COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K07657,ko:K07658,ko:K18941	ko02020,map02020	M00434,M00716,M00717	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5032625_5	1499967.BAYZ01000171_gene5606	4.342e-110	364.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2
HKD1_k127_5032625_11	1499967.BAYZ01000158_gene471	4.806e-93	312.0	COG1131@1|root,COG1131@2|Bacteria,2NR18@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	yxlF_1	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5032625_4	1499967.BAYZ01000158_gene472	8.052e-112	376.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase_2,NPCBM,NPCBM_assoc
HKD1_k127_5038871_3	443143.GM18_0377	0.0002478	46.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y50@68525|delta/epsilon subdivisions,2WUBF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,GAF_3,HTH_8,PAS_4,Sigma54_activat
HKD1_k127_5038871_2	690850.Desaf_2584	4.344e-43	169.0	COG0385@1|root,COG0385@2|Bacteria,1Q36S@1224|Proteobacteria,42WV7@68525|delta/epsilon subdivisions,2WSXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Bile acid sodium symporter	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD1_k127_5038871_1	700598.Niako_2137	1.945e-74	256.0	2C0ZU@1|root,32R7S@2|Bacteria,4P4KK@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5038871_0	1397527.Q670_04240	2.503e-77	261.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,1RMY9@1236|Gammaproteobacteria,1XHZG@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
HKD1_k127_5043958_0	335543.Sfum_0634	1.232e-180	580.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,1MU0R@1224|Proteobacteria,42MW3@68525|delta/epsilon subdivisions,2WIXV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GT	Pyruvate phosphate dikinase PEP	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD1_k127_5046311_4	1123261.AXDW01000004_gene2894	4.39e-05	46.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,1RNMP@1236|Gammaproteobacteria,1X4FA@135614|Xanthomonadales	135614|Xanthomonadales	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_5046311_1	1047013.AQSP01000099_gene1495	5.106e-68	239.0	COG0805@1|root,COG0805@2|Bacteria,2NPGB@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	GO:0003674,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0022804,GO:0022857,GO:0022884,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0040007,GO:0042886,GO:0042887,GO:0043953,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_5046311_3	1047013.AQSP01000099_gene1496	4.523e-17	85.0	COG1826@1|root,COG1826@2|Bacteria,2NQ3N@2323|unclassified Bacteria	2|Bacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116,ko:K03117,ko:K03646	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	2.A.64,2.C.1.2	-	-	MttA_Hcf106
HKD1_k127_5046311_0	903818.KI912268_gene2333	6.527e-97	338.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD1_k127_5046311_2	1191523.MROS_0698	5.596e-35	135.0	COG3033@1|root,COG3033@2|Bacteria	2|Bacteria	E	tryptophanase activity	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_5054033_0	272134.KB731325_gene653	2.179e-39	151.0	COG1943@1|root,COG1943@2|Bacteria,1G9TK@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_5054033_3	1552758.NC00_03515	4.277e-08	57.0	COG1396@1|root,COG1396@2|Bacteria,1NGM7@1224|Proteobacteria,1SGD3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Helix-turn-helix domain	ahdIC	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD1_k127_5054033_1	1267535.KB906767_gene5154	6.363e-23	112.0	COG4653@1|root,COG4653@2|Bacteria	2|Bacteria	G	Phage capsid family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S78,Phage_capsid
HKD1_k127_5054033_4	1047013.AQSP01000109_gene2428	5.783e-07	57.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
HKD1_k127_5054033_2	909663.KI867150_gene2875	4.533e-21	100.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42Q95@68525|delta/epsilon subdivisions,2WKM2@28221|Deltaproteobacteria,2MS1I@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_5,Phage_integrase
HKD1_k127_5057000_8	671143.DAMO_2315	1.086e-59	208.0	COG0289@1|root,COG0289@2|Bacteria,2NPX5@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008839,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019752,GO:0019877,GO:0042802,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.17.1.8	ko:K00215,ko:K03546	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	iIT341.HP0510,iLJ478.TM1520,iSbBS512_1146.SbBS512_E0035	DapB_C,DapB_N
HKD1_k127_5057000_1	671143.DAMO_2313	3.186e-170	542.0	COG0436@1|root,COG0436@2|Bacteria,2NQG2@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	dapL	-	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_5057000_11	1329516.JPST01000015_gene785	2.381e-28	119.0	COG1539@1|root,COG1539@2|Bacteria,1VA0I@1239|Firmicutes,4HKKK@91061|Bacilli,27C6J@186824|Thermoactinomycetaceae	91061|Bacilli	H	Dihydroneopterin aldolase	folB	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD1_k127_5057000_10	1111069.TCCBUS3UF1_19630	7.798e-33	136.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD1_k127_5057000_6	671143.DAMO_2311	1.716e-85	296.0	COG1428@1|root,COG1428@2|Bacteria,2NPEH@2323|unclassified Bacteria	2|Bacteria	F	Deoxynucleoside kinase	dgk	-	2.7.1.113	ko:K15518	ko00230,map00230	-	R01967	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HPPK,dNK
HKD1_k127_5057000_5	264732.Moth_0141	1.994e-89	304.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,42F66@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD1_k127_5057000_9	671143.DAMO_2308	5.529e-33	132.0	COG2001@1|root,COG2001@2|Bacteria,2NPTY@2323|unclassified Bacteria	2|Bacteria	K	MraZ protein, putative antitoxin-like	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_5057000_13	1003195.SCAT_0250	7.285e-05	51.0	COG1366@1|root,COG1366@2|Bacteria,2IHX1@201174|Actinobacteria	201174|Actinobacteria	T	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,STAS_2
HKD1_k127_5057000_4	671143.DAMO_2307	3.094e-91	309.0	COG0275@1|root,COG0275@2|Bacteria,2NP8Y@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071424,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_5057000_12	671143.DAMO_2306	1.942e-16	83.0	2DT1T@1|root,33IAD@2|Bacteria	2|Bacteria	S	Evidence 5 No homology to any previously reported sequences	-	-	-	-	-	-	-	-	-	-	-	-	FtsL
HKD1_k127_5057000_3	1121918.ARWE01000001_gene867	3.268e-138	459.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,42M1T@68525|delta/epsilon subdivisions,2WK0W@28221|Deltaproteobacteria,43TBV@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PASTA domain	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD1_k127_5057000_2	671143.DAMO_2304	1.95e-167	543.0	COG0769@1|root,COG0769@2|Bacteria,2NNZM@2323|unclassified Bacteria	2|Bacteria	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008765,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	3.4.16.4,6.3.2.10,6.3.2.13	ko:K01928,ko:K03587,ko:K15792	ko00300,ko00550,ko01501,map00300,map00550,map01501	-	R02788,R04617	RC00064,RC00090,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	iECO103_1326.ECO103_0087,iECO111_1330.ECO111_0088,iECW_1372.ECW_m0084,iEKO11_1354.EKO11_3829,iNJ661.Rv2158c,iWFL_1372.ECW_m0084,ic_1306.c0103	DUF1727,Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_5057000_7	671143.DAMO_2303	1.991e-76	263.0	COG2267@1|root,COG2267@2|Bacteria,2NPU3@2323|unclassified Bacteria	2|Bacteria	I	Alpha/beta hydrolase family	acoC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6,Biotin_lipoyl,E3_binding
HKD1_k127_5057000_0	671143.DAMO_2302	3.037e-179	579.0	COG0770@1|root,COG0770@2|Bacteria,2NP4Q@2323|unclassified Bacteria	2|Bacteria	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_5065325_3	1123290.AUDQ01000010_gene1512	2.383e-33	133.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,4HBWA@91061|Bacilli,26E83@186818|Planococcaceae	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	yflP	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_5065325_4	670487.Ocepr_0060	1.127e-06	58.0	2CQ1K@1|root,330SJ@2|Bacteria,1WKKB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_5065325_2	1157490.EL26_07415	1.805e-131	435.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,4HADN@91061|Bacilli,279QY@186823|Alicyclobacillaceae	91061|Bacilli	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_5065325_0	378806.STAUR_3925	3.295e-179	576.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Y93@68525|delta/epsilon subdivisions,2WU1Y@28221|Deltaproteobacteria,2YWK2@29|Myxococcales	28221|Deltaproteobacteria	L	Reverse transcriptase (RNA-dependent DNA polymerase)	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
HKD1_k127_5065325_1	383372.Rcas_1032	1.806e-142	461.0	COG0161@1|root,COG0161@2|Bacteria,2G62N@200795|Chloroflexi,376DU@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_5065815_3	595537.Varpa_1507	2.266e-23	101.0	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2VQS7@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_5065815_1	573413.Spirs_2752	4.117e-58	226.0	COG0440@1|root,COG0440@2|Bacteria,2J7CQ@203691|Spirochaetes	203691|Spirochaetes	E	Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD1_k127_5065815_0	573413.Spirs_2753	2.116e-204	651.0	COG0028@1|root,COG0028@2|Bacteria,2J5EZ@203691|Spirochaetes	203691|Spirochaetes	H	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_5065815_2	1379698.RBG1_1C00001G0617	1.433e-53	192.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5070917_0	1242864.D187_004264	1.635e-158	505.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,42RJF@68525|delta/epsilon subdivisions,2WNGK@28221|Deltaproteobacteria,2Z0BU@29|Myxococcales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_5070917_1	497964.CfE428DRAFT_2890	1.094e-131	430.0	COG0058@1|root,COG0058@2|Bacteria,46S5T@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_5082897_3	555088.DealDRAFT_1866	1.517e-83	282.0	COG0047@1|root,COG0047@2|Bacteria,1TP1B@1239|Firmicutes,24A2E@186801|Clostridia,42KG2@68298|Syntrophomonadaceae	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_5082897_0	671143.DAMO_0586	2.5e-323	1004.0	COG0046@1|root,COG0046@2|Bacteria,2NNPS@2323|unclassified Bacteria	2|Bacteria	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004642,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0017076,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_5082897_1	671143.DAMO_0587	2.176e-163	528.0	COG0460@1|root,COG0460@2|Bacteria,2NP8S@2323|unclassified Bacteria	2|Bacteria	E	homoserine dehydrogenase	hom	GO:0003674,GO:0003824,GO:0004412,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0030312,GO:0040007,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0055114,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1294,iSB619.SA_RS06610	ACT,Homoserine_dh,NAD_binding_3
HKD1_k127_5082897_2	671143.DAMO_0588	3.861e-152	491.0	COG0498@1|root,COG0498@2|Bacteria,2NP4T@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	thrC	GO:0003674,GO:0003824,GO:0004795,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009088,GO:0009987,GO:0016020,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0546,iSB619.SA_RS06615,iYO844.BSU32250	PALP
HKD1_k127_508754_4	443144.GM21_0342	7.539e-19	88.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria,43TMR@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
HKD1_k127_508754_0	439235.Dalk_0845	1.32e-102	338.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2MKSR@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HKD1_k127_508754_1	234267.Acid_2161	3.142e-65	241.0	2DV06@1|root,33TAT@2|Bacteria,3Y720@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_508754_3	247490.KSU1_D0904	1.172e-34	151.0	COG1807@1|root,COG1807@2|Bacteria,2J1H1@203682|Planctomycetes	203682|Planctomycetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_508754_2	56780.SYN_02931	7.121e-51	185.0	COG0521@1|root,COG0521@2|Bacteria,1R9W2@1224|Proteobacteria,42PGH@68525|delta/epsilon subdivisions,2WPJ6@28221|Deltaproteobacteria,2MQG2@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	molybdenum cofactor	moaB	-	2.7.7.75	ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HKD1_k127_5113175_1	671143.DAMO_1341	7.325e-170	539.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS10690,iYO844.BSU28280	HMGL-like,LeuA_dimer
HKD1_k127_5113175_2	671143.DAMO_1342	1.166e-147	475.0	COG0136@1|root,COG0136@2|Bacteria,2NNX3@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004073,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006549,GO:0006553,GO:0006555,GO:0006566,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009081,GO:0009082,GO:0009085,GO:0009086,GO:0009088,GO:0009089,GO:0009097,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1523	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_5113175_3	671143.DAMO_1343	1.898e-74	259.0	COG0101@1|root,COG0101@2|Bacteria,2NPEC@2323|unclassified Bacteria	2|Bacteria	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016853,GO:0016866,GO:0031119,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD1_k127_5113175_0	671143.DAMO_1355	0.0	1162.0	COG0495@1|root,COG0495@2|Bacteria,2NNQH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	GO:0003674,GO:0003824,GO:0004812,GO:0004823,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006429,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_2300	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_5113175_4	671143.DAMO_1356	5.025e-16	91.0	COG2980@1|root,COG2980@2|Bacteria,2NQ1I@2323|unclassified Bacteria	2|Bacteria	M	Evidence 5 No homology to any previously reported sequences	lptE	GO:0001530,GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0008289,GO:0009279,GO:0009987,GO:0010876,GO:0015920,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044462,GO:0044464,GO:0045229,GO:0051179,GO:0051234,GO:0061024,GO:0071702,GO:0071709,GO:0071840,GO:0071944,GO:0097367,GO:1901264	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iECH74115_1262.ECH74115_0730,iECSP_1301.ECSP_0694,iECs_1301.ECs0679,iG2583_1286.G2583_0804,iZ_1308.Z0788	LptE
HKD1_k127_5113322_0	1254432.SCE1572_20250	1.507e-174	556.0	COG0559@1|root,COG0683@1|root,COG0559@2|Bacteria,COG0683@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2Z0ZI@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5113322_2	1254432.SCE1572_20250	1.603e-118	387.0	COG0559@1|root,COG0683@1|root,COG0559@2|Bacteria,COG0683@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria,2Z0ZI@29|Myxococcales	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997,ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5113322_1	1254432.SCE1572_20255	9.614e-134	432.0	COG4177@1|root,COG4177@2|Bacteria,1NPII@1224|Proteobacteria,42TEH@68525|delta/epsilon subdivisions,2WPV9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5113322_3	1254432.SCE1572_20260	9.864e-100	332.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,42QV6@68525|delta/epsilon subdivisions,2WMN1@28221|Deltaproteobacteria,2Z08T@29|Myxococcales	28221|Deltaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_5113322_4	1254432.SCE1572_20265	5.178e-98	325.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42M9C@68525|delta/epsilon subdivisions,2WJ75@28221|Deltaproteobacteria,2YV0S@29|Myxococcales	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_5113322_5	863365.XHC_0755	7.02e-22	99.0	28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,1RY8I@1236|Gammaproteobacteria,1X6I4@135614|Xanthomonadales	135614|Xanthomonadales	M	S1/P1 Nuclease	-	-	3.1.30.1	ko:K05986	-	-	-	-	ko00000,ko01000	-	-	-	S1-P1_nuclease
HKD1_k127_5113322_6	1453500.AT05_00405	1.544e-12	71.0	28JIP@1|root,2Z82C@2|Bacteria,4NFN9@976|Bacteroidetes,1HZ0J@117743|Flavobacteriia	976|Bacteroidetes	S	S1 P1 nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
HKD1_k127_5119803_1	748247.AZKH_1971	3.448e-47	173.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_5119803_0	56780.SYN_02956	1.689e-160	524.0	COG2202@1|root,COG2203@1|root,COG3829@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	GAF,HTH_8,PAS,PAS_3,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_5123032_0	138119.DSY4504	6.15e-47	178.0	COG0330@1|root,COG0330@2|Bacteria,1UZJK@1239|Firmicutes,24IK1@186801|Clostridia,261BT@186807|Peptococcaceae	186801|Clostridia	O	PFAM SPFH domain Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_5123032_1	864702.OsccyDRAFT_1858	1.387e-21	99.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1G1M7@1117|Cyanobacteria,1H7YE@1150|Oscillatoriales	1117|Cyanobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg,STAS
HKD1_k127_512503_2	926569.ANT_22050	8.193e-73	248.0	COG3260@1|root,COG3260@2|Bacteria,2G8XX@200795|Chloroflexi	200795|Chloroflexi	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	echC	-	-	ko:K14088	-	-	-	-	ko00000	-	-	-	Oxidored_q6
HKD1_k127_512503_0	926569.ANT_22030	5.456e-168	549.0	COG3261@1|root,COG3261@2|Bacteria,2G8BA@200795|Chloroflexi	200795|Chloroflexi	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	-	ko:K14090	-	-	-	-	ko00000	-	-	-	Complex1_49kDa,NiFeSe_Hases
HKD1_k127_512503_1	926569.ANT_22020	1.249e-114	390.0	COG1005@1|root,COG1005@2|Bacteria	2|Bacteria	C	quinone binding	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_512503_4	926569.ANT_22010	7.789e-47	186.0	COG1143@1|root,COG1143@2|Bacteria,2G9SP@200795|Chloroflexi	200795|Chloroflexi	C	4Fe-4S binding domain	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	Fer4
HKD1_k127_512503_8	926569.ANT_22000	3.784e-24	109.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	3.4.23.51	ko:K00442,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000,ko01002	-	-	-	HycI
HKD1_k127_512503_7	909663.KI867150_gene226	2.579e-27	113.0	COG2336@1|root,COG2336@2|Bacteria	2|Bacteria	T	PFAM SpoVT AbrB	-	-	-	ko:K07172	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HKD1_k127_512503_5	933262.AXAM01000098_gene3465	1.41e-46	169.0	COG2337@1|root,COG2337@2|Bacteria,1MZJ8@1224|Proteobacteria	1224|Proteobacteria	T	Transcriptional modulator of MazE toxin, MazF	chpA	GO:0001558,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0022607,GO:0030308,GO:0032991,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0040008,GO:0042802,GO:0042803,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044877,GO:0045926,GO:0046483,GO:0046700,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051259,GO:0051291,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K07171,ko:K18841	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_512503_3	1223521.BBJX01000009_gene1208	1.564e-56	205.0	COG3189@1|root,COG3189@2|Bacteria,1RHYB@1224|Proteobacteria,2VSIB@28216|Betaproteobacteria,4AECV@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_512503_6	797209.ZOD2009_15771	9.75e-38	147.0	COG0500@1|root,arCOG02702@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_5131147_8	1380394.JADL01000001_gene1981	1.095e-101	343.0	COG1840@1|root,COG1840@2|Bacteria,1PDYC@1224|Proteobacteria,2TSWW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Bacterial extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD1_k127_5131147_6	935948.KE386495_gene1414	2.2e-135	448.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,42FE3@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	FGGY_C,FGGY_N
HKD1_k127_5131147_14	759914.BP951000_0494	6.135e-64	234.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.103,1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko00650,ko01100,map00040,map00051,map00260,map00650,map01100	M00014	R00875,R01465,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5131147_15	1382315.JPOI01000001_gene3016	3.354e-62	223.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,1WEUB@129337|Geobacillus	91061|Bacilli	IQ	PFAM Short-chain dehydrogenase reductase SDR	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
HKD1_k127_5131147_10	649638.Trad_2184	9.431e-97	324.0	COG0395@1|root,COG0395@2|Bacteria,1WK7B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Carbohydrate ABC transporter membrane protein 2, CUT1 family	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5131147_11	1122915.AUGY01000044_gene7533	8.245e-84	289.0	COG1175@1|root,COG1175@2|Bacteria,1V109@1239|Firmicutes,4HC5A@91061|Bacilli,26UKR@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5131147_7	319795.Dgeo_2821	1.172e-103	353.0	COG1653@1|root,COG1653@2|Bacteria,1WJQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_5131147_13	319795.Dgeo_2821	1.54e-68	250.0	COG1653@1|root,COG1653@2|Bacteria,1WJQ3@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_5131147_19	247490.KSU1_D0755	1.185e-33	140.0	COG0546@1|root,COG0546@2|Bacteria,2J0RU@203682|Planctomycetes	203682|Planctomycetes	S	HAD-hyrolase-like	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD1_k127_5131147_16	1297742.A176_04893	1.4e-58	214.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,42QUA@68525|delta/epsilon subdivisions,2WP2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD1_k127_5131147_20	1485545.JQLW01000006_gene295	8.082e-25	120.0	COG1716@1|root,COG1716@2|Bacteria,1MW1M@1224|Proteobacteria	1224|Proteobacteria	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD1_k127_5131147_17	671143.DAMO_0949	2.304e-51	191.0	COG2045@1|root,COG2045@2|Bacteria,2NPF1@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ComB family	comB	GO:0003674,GO:0003824,GO:0016829,GO:0016830,GO:0016831,GO:0050545	3.1.3.71	ko:K05979	ko00680,ko01120,map00680,map01120	M00358	R05789	RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	2-ph_phosp
HKD1_k127_5131147_9	671143.DAMO_2129	1.88e-99	339.0	COG0501@1|root,COG0501@2|Bacteria,2NP9X@2323|unclassified Bacteria	2|Bacteria	O	CAAX prenyl protease N-terminal, five membrane helices	agmM	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD1_k127_5131147_0	671143.DAMO_2134	2.155e-300	933.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006259,GO:0006260,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016874,GO:0016886,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0040007,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	2.7.7.7,6.5.1.2	ko:K01972,ko:K02342,ko:K04096,ko:K12472	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,ko04144,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440,map04144	M00260	R00375,R00376,R00377,R00378,R00382	RC00005,RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400,ko04131	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5,RNase_T
HKD1_k127_5131147_21	1121423.JONT01000017_gene105	7.001e-09	67.0	COG0110@1|root,COG0110@2|Bacteria,1V1SM@1239|Firmicutes,25B93@186801|Clostridia,26395@186807|Peptococcaceae	186801|Clostridia	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD1_k127_5131147_12	1304865.JAGF01000001_gene3272	2.59e-81	282.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5131147_2	891968.Anamo_1360	1.137e-199	629.0	COG0624@1|root,COG0624@2|Bacteria,3T9SM@508458|Synergistetes	508458|Synergistetes	E	M20 DapE family protein YgeY	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5131147_18	641491.DND132_1347	1.12e-46	175.0	COG3090@1|root,COG3090@2|Bacteria,1RCS9@1224|Proteobacteria	1224|Proteobacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_5131147_3	1121033.AUCF01000005_gene5214	1.002e-176	572.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JPIG@204441|Rhodospirillales	204441|Rhodospirillales	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5131147_4	1121439.dsat_2227	4.954e-150	482.0	COG1638@1|root,COG1638@2|Bacteria,1NJX4@1224|Proteobacteria,42QE0@68525|delta/epsilon subdivisions,2WP8A@28221|Deltaproteobacteria,2MH2D@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_5131147_5	1304888.ATWF01000001_gene583	2.688e-136	450.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_5131147_1	1265505.ATUG01000002_gene2214	5.949e-208	654.0	COG0031@1|root,COG0031@2|Bacteria,1QQKZ@1224|Proteobacteria,42PVJ@68525|delta/epsilon subdivisions,2WKKY@28221|Deltaproteobacteria,2MMPP@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HKD1_k127_5138820_0	247490.KSU1_C0672	0.0	1041.0	COG4096@1|root,COG4096@2|Bacteria,2IXTV@203682|Planctomycetes	203682|Planctomycetes	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,Helicase_C,ResIII
HKD1_k127_5138820_1	247490.KSU1_C0671	1.156e-258	805.0	COG0286@1|root,COG0286@2|Bacteria,2IXEQ@203682|Planctomycetes	203682|Planctomycetes	V	COG0286 Type I restriction-modification system	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
HKD1_k127_5138820_3	1173023.KE650771_gene588	7.301e-22	96.0	COG2442@1|root,COG2442@2|Bacteria,1G9FC@1117|Cyanobacteria,1JMBK@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_5138820_4	1173028.ANKO01000020_gene5475	1.981e-16	84.0	COG4634@1|root,COG4634@2|Bacteria,1GA03@1117|Cyanobacteria,1HDVT@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5138820_2	522306.CAP2UW1_3123	1.697e-33	138.0	COG0732@1|root,COG0732@2|Bacteria,1REK4@1224|Proteobacteria,2VT21@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Restriction endonuclease S	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
HKD1_k127_5140957_7	1423743.JCM14108_413	5.644e-05	45.0	COG1541@1|root,COG1541@2|Bacteria,1UYJ0@1239|Firmicutes,4HD80@91061|Bacilli	91061|Bacilli	H	Acyl-protein synthetase, LuxE	-	-	-	-	-	-	-	-	-	-	-	-	LuxE
HKD1_k127_5140957_2	1123405.AUMM01000009_gene1165	1.93e-100	344.0	COG1012@1|root,COG1012@2|Bacteria,1TSYP@1239|Firmicutes,4HE2I@91061|Bacilli	91061|Bacilli	C	Acyl-CoA reductase (LuxC)	-	-	-	-	-	-	-	-	-	-	-	-	LuxC
HKD1_k127_5140957_3	595537.Varpa_3960	1.206e-72	253.0	COG1116@1|root,COG1116@2|Bacteria,1MUIM@1224|Proteobacteria,2WEDA@28216|Betaproteobacteria,4ADUF@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_5140957_4	333138.LQ50_01030	4.561e-71	250.0	COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,4HARZ@91061|Bacilli,1ZQFJ@1386|Bacillus	91061|Bacilli	P	COG0600 ABC-type nitrate sulfonate bicarbonate transport system, permease component	tauC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_5140957_1	420246.GTNG_2036	2.58e-103	352.0	COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,4HEW0@91061|Bacilli,1WH5U@129337|Geobacillus	91061|Bacilli	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_5140957_5	710685.MycrhN_3209	1.245e-44	176.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria,237DD@1762|Mycobacteriaceae	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_5140957_0	469371.Tbis_1854	0.0	1292.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,2GM5Q@201174|Actinobacteria,4DYUS@85010|Pseudonocardiales	201174|Actinobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016020,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0030312,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD1_k127_5140957_6	556269.ACDQ01000021_gene2081	1.151e-43	163.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,2VNWB@28216|Betaproteobacteria,478EE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_5155601_3	663610.JQKO01000009_gene460	1.279e-22	101.0	COG2020@1|root,COG2020@2|Bacteria,1MZ7S@1224|Proteobacteria,2VAAU@28211|Alphaproteobacteria,3NCUE@45404|Beijerinckiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_5155601_1	318996.AXAZ01000008_gene4295	1.988e-80	280.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_5155601_2	1123393.KB891317_gene2209	2.222e-67	230.0	COG0662@1|root,COG0662@2|Bacteria,1QW6S@1224|Proteobacteria	1224|Proteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5155601_0	95619.PM1_0211575	6.54e-122	400.0	COG1234@1|root,COG1234@2|Bacteria,1R64Z@1224|Proteobacteria,1S1KW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG1234 Metal-dependent hydrolases of the beta-lactamase superfamily III	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_5158460_0	335543.Sfum_0638	1.385e-175	556.0	COG0730@1|root,COG0730@2|Bacteria,1NX2Y@1224|Proteobacteria,42P1U@68525|delta/epsilon subdivisions,2WJZV@28221|Deltaproteobacteria	1224|Proteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_5161291_5	340099.Teth39_1975	1.506e-24	105.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HKD1_k127_5161291_1	1038862.KB893806_gene3354	1.191e-97	328.0	COG0329@1|root,COG0329@2|Bacteria,1PE99@1224|Proteobacteria,2TSAK@28211|Alphaproteobacteria,3JWWX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EM	Dihydrodipicolinate synthetase family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_5161291_4	525904.Tter_0652	1.097e-40	166.0	COG0673@1|root,COG0673@2|Bacteria,2NREF@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5161291_3	1499967.BAYZ01000054_gene4806	1.242e-48	191.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_5161291_6	1449126.JQKL01000002_gene1601	4.812e-15	83.0	COG3090@1|root,COG3090@2|Bacteria,1VFX5@1239|Firmicutes,24TW7@186801|Clostridia	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_5161291_0	1305836.AXVE01000011_gene1073	9.468e-100	341.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H9WK@91061|Bacilli,26ES0@186818|Planococcaceae	91061|Bacilli	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5161291_2	1238450.VIBNISOn1_p0041	1.876e-53	197.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RMGZ@1236|Gammaproteobacteria,1XYSU@135623|Vibrionales	135623|Vibrionales	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_5185214_3	671143.DAMO_2944	1.298e-189	603.0	COG0172@1|root,COG0172@2|Bacteria,2NNRH@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528,iSDY_1059.SDY_2368	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_5185214_0	671143.DAMO_2945	0.0	1246.0	COG0188@1|root,COG0188@2|Bacteria,2NNNR@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_5185214_1	671143.DAMO_2946	0.0	1234.0	COG0187@1|root,COG0187@2|Bacteria,2NNSN@2323|unclassified Bacteria	2|Bacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_5185214_5	671143.DAMO_2947	4.207e-118	391.0	COG0592@1|root,COG0592@2|Bacteria,2NP7D@2323|unclassified Bacteria	2|Bacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD1_k127_5185214_14	272633.26454499	5.706e-11	64.0	COG0230@1|root,COG0230@2|Bacteria	2|Bacteria	J	Ribosomal protein L34	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD1_k127_5185214_15	391615.ABSJ01000039_gene1851	2.09e-05	51.0	COG0594@1|root,COG0594@2|Bacteria	2|Bacteria	J	ribonuclease P activity	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031123,GO:0031404,GO:0031974,GO:0031981,GO:0032991,GO:0033204,GO:0034414,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0040007,GO:0042301,GO:0042779,GO:0042780,GO:0042781,GO:0043167,GO:0043168,GO:0043170,GO:0043199,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043628,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1901363,GO:1901681,GO:1902494,GO:1902555,GO:1905267,GO:1905348,GO:1990904	3.1.26.5	ko:K03536,ko:K08998	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_5185214_13	1453503.AU05_13910	5.288e-26	108.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1YGXT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD1_k127_5185214_4	671143.DAMO_2952	8.303e-156	509.0	COG0706@1|root,COG0706@2|Bacteria,2NP6C@2323|unclassified Bacteria	2|Bacteria	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	GO:0002790,GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0022607,GO:0031224,GO:0031226,GO:0032940,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0051179,GO:0051205,GO:0051234,GO:0051259,GO:0051260,GO:0051641,GO:0061024,GO:0065003,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD1_k127_5185214_12	574087.Acear_2346	2.35e-28	124.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,3WAMX@53433|Halanaerobiales	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD1_k127_5185214_7	1125863.JAFN01000001_gene2683	1.039e-92	311.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,42MTF@68525|delta/epsilon subdivisions,2WJ6X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_5185214_8	671143.DAMO_2955	5.043e-85	291.0	COG1475@1|root,COG1475@2|Bacteria,2NP7S@2323|unclassified Bacteria	2|Bacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_5185214_16	794903.OPIT5_03115	0.000955	49.0	2A1DB@1|root,30PKC@2|Bacteria,46WF1@74201|Verrucomicrobia,3K8HN@414999|Opitutae	414999|Opitutae	S	Protein of unknown function (DUF4013)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4013
HKD1_k127_5185214_11	1123072.AUDH01000005_gene1737	1.157e-69	256.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSZ8@28211|Alphaproteobacteria,2JWD7@204441|Rhodospirillales	204441|Rhodospirillales	EH	Thiamine pyrophosphate enzyme, central domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_5185214_2	234267.Acid_1079	1.243e-228	720.0	COG1866@1|root,COG1866@2|Bacteria,3Y3U4@57723|Acidobacteria	57723|Acidobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	-	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD1_k127_5185214_6	402777.KB235903_gene1431	1.373e-107	365.0	COG1653@1|root,COG1653@2|Bacteria,1G04B@1117|Cyanobacteria,1H8YD@1150|Oscillatoriales	1117|Cyanobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_5185214_9	1123023.JIAI01000001_gene7302	1.522e-77	268.0	COG1175@1|root,COG1175@2|Bacteria,2GJGB@201174|Actinobacteria,4E12E@85010|Pseudonocardiales	201174|Actinobacteria	P	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
HKD1_k127_5185214_10	1123023.JIAI01000001_gene7301	2.721e-77	279.0	COG0395@1|root,COG0395@2|Bacteria,2GNGG@201174|Actinobacteria	201174|Actinobacteria	G	Binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_519727_2	1380394.JADL01000007_gene4559	3.864e-132	427.0	COG3892@1|root,COG3892@2|Bacteria,1R1QJ@1224|Proteobacteria,2TZT2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Uncharacterized protein conserved in bacteria (DUF2090)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2090
HKD1_k127_519727_3	1121918.ARWE01000001_gene3108	1.406e-102	340.0	COG0580@1|root,COG0580@2|Bacteria,1MZ47@1224|Proteobacteria	1224|Proteobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_519727_1	1121875.KB907549_gene1996	5.943e-168	535.0	COG1063@1|root,COG1063@2|Bacteria,4P3W3@976|Bacteroidetes	976|Bacteroidetes	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HKD1_k127_519727_0	1267534.KB906754_gene3315	0.0	1355.0	COG3408@1|root,COG3408@2|Bacteria,3Y47W@57723|Acidobacteria,2JKGP@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_519727_4	522306.CAP2UW1_1125	2.827e-38	148.0	2E06S@1|root,32VUR@2|Bacteria,1N3ZV@1224|Proteobacteria,2W4J8@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5198991_14	316057.RPD_0053	1.53e-97	327.0	COG0559@1|root,COG0559@2|Bacteria,1MY1E@1224|Proteobacteria,2U0TW@28211|Alphaproteobacteria,3JUC4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5198991_15	1089551.KE386572_gene1395	6.83e-83	286.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VF1H@28211|Alphaproteobacteria,4BRP8@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5198991_22	316057.RPD_0051	1.84e-65	231.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2TTG6@28211|Alphaproteobacteria,3JUVS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_5198991_19	706587.Desti_4656	1.148e-79	272.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,42R5R@68525|delta/epsilon subdivisions,2WMRR@28221|Deltaproteobacteria,2MR65@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_5198991_35	671143.DAMO_1260	7.279e-05	50.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_5198991_29	644966.Tmar_1677	1.373e-34	139.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_5198991_10	63737.Npun_F1045	1.639e-118	397.0	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria,1HR9W@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_5198991_0	880072.Desac_1402	0.0	1353.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_5198991_2	671143.DAMO_1249	0.0	1148.0	COG1615@1|root,COG1615@2|Bacteria,2NQSF@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD1_k127_5198991_20	292459.STH3180	2.681e-68	239.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1V3V0@1239|Firmicutes,24QVX@186801|Clostridia	186801|Clostridia	H	Molybdopterin converting factor subunit	-	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HKD1_k127_5198991_9	671143.DAMO_1224	3.096e-131	438.0	COG0457@1|root,COG0457@2|Bacteria	671143.DAMO_1224|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5198991_17	671143.DAMO_0756	2.776e-82	287.0	COG0477@1|root,COG2814@2|Bacteria,2NRCB@2323|unclassified Bacteria	2|Bacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_5198991_8	1499967.BAYZ01000196_gene3073	2.202e-154	499.0	COG2379@1|root,COG2379@2|Bacteria,2NNQP@2323|unclassified Bacteria	2|Bacteria	G	MOFRL family	ttuD	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HKD1_k127_5198991_28	671143.DAMO_2617	8.221e-41	157.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD1_k127_5198991_12	926561.KB900617_gene1546	5.224e-113	378.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,3WAKZ@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM competence damage-inducible protein CinA	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_5198991_32	765914.ThisiDRAFT_0372	7.82e-25	117.0	COG1267@1|root,COG1267@2|Bacteria,1MZJA@1224|Proteobacteria,1S68A@1236|Gammaproteobacteria,1WY89@135613|Chromatiales	135613|Chromatiales	I	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)	-	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HKD1_k127_5198991_11	1303518.CCALI_00284	1.011e-117	399.0	COG0621@1|root,COG0621@2|Bacteria	2|Bacteria	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	rimO	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016782,GO:0018193,GO:0018197,GO:0018198,GO:0018339,GO:0019538,GO:0035596,GO:0035599,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0048037,GO:0050497,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:1901564	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_5198991_25	357808.RoseRS_1949	6.749e-63	240.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,2G8CK@200795|Chloroflexi,3776C@32061|Chloroflexia	32061|Chloroflexia	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HKD1_k127_5198991_24	589865.DaAHT2_1107	4.038e-63	236.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42NFR@68525|delta/epsilon subdivisions,2X5E8@28221|Deltaproteobacteria,2MPS3@213118|Desulfobacterales	28221|Deltaproteobacteria	T	SMART ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_5198991_26	521098.Aaci_1469	2.601e-49	181.0	COG1666@1|root,COG1666@2|Bacteria,1V3UR@1239|Firmicutes,4HHVD@91061|Bacilli,278D5@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the UPF0234 family	yitK	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HKD1_k127_5198991_27	671143.DAMO_2621	4.606e-47	177.0	COG2834@1|root,COG2834@2|Bacteria,2NQ6V@2323|unclassified Bacteria	2|Bacteria	M	Outer membrane lipoprotein carrier protein LolA	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD1_k127_5198991_4	671143.DAMO_2622	4.876e-219	705.0	COG1674@1|root,COG1674@2|Bacteria,2NNVB@2323|unclassified Bacteria	2|Bacteria	D	Ftsk_gamma	ftsK	GO:0000920,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006950,GO:0006970,GO:0007059,GO:0008094,GO:0008150,GO:0009628,GO:0009651,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0015616,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0033676,GO:0042221,GO:0042623,GO:0042802,GO:0043085,GO:0043565,GO:0044093,GO:0044425,GO:0044459,GO:0044464,GO:0045893,GO:0045935,GO:0046677,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051301,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0070887,GO:0071236,GO:0071944,GO:0080090,GO:0097159,GO:0140097,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_5198991_5	671143.DAMO_2623	2.534e-218	690.0	COG0595@1|root,COG0595@2|Bacteria,2NNMI@2323|unclassified Bacteria	2|Bacteria	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004527,GO:0004532,GO:0004534,GO:0004540,GO:0005488,GO:0005515,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008409,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0022613,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0090503,GO:0140098,GO:1901360	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD1_k127_5198991_1	671143.DAMO_2624	0.0	1255.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_5198991_13	309799.DICTH_1516	7.531e-110	364.0	COG1210@1|root,COG1210@2|Bacteria	2|Bacteria	M	Utp--glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0646	NTP_transferase
HKD1_k127_5198991_33	1157490.EL26_19865	1.291e-18	89.0	COG1950@1|root,COG1950@2|Bacteria,1VF4I@1239|Firmicutes,4I6EK@91061|Bacilli,278PC@186823|Alicyclobacillaceae	91061|Bacilli	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HKD1_k127_5198991_6	1162668.LFE_2157	1.274e-196	633.0	COG1032@1|root,COG1032@2|Bacteria,3J18Y@40117|Nitrospirae	40117|Nitrospirae	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_5198991_30	671143.DAMO_0140	3.103e-29	119.0	COG1278@1|root,COG1278@2|Bacteria,2NPXP@2323|unclassified Bacteria	2|Bacteria	K	'Cold-shock' DNA-binding domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_5198991_31	1122138.AQUZ01000074_gene7315	3.74e-25	110.0	COG0346@1|root,COG0346@2|Bacteria,2ISP0@201174|Actinobacteria	201174|Actinobacteria	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
HKD1_k127_5198991_21	530564.Psta_2957	2.205e-66	239.0	COG2055@1|root,COG2055@2|Bacteria,2IWXD@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	ko:K13574	-	-	-	-	ko00000,ko01000	-	-	-	Ldh_2
HKD1_k127_5198991_7	886293.Sinac_2122	9.798e-192	610.0	COG2317@1|root,COG2317@2|Bacteria,2IXSU@203682|Planctomycetes	203682|Planctomycetes	E	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues	-	-	3.4.17.19	ko:K01299	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M32
HKD1_k127_5198991_18	426117.M446_2042	8.13e-81	280.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,1JRED@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	PFAM Dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD1_k127_5198991_3	1499967.BAYZ01000028_gene1283	2.242e-219	688.0	COG0065@1|root,COG0065@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0030312,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.3,4.2.1.33,4.2.1.35,4.2.1.85	ko:K01681,ko:K01703,ko:K17749,ko:K20452	ko00020,ko00290,ko00400,ko00630,ko00660,ko00720,ko00760,ko00966,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00400,map00630,map00660,map00720,map00760,map00966,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00432,M00535,M00740	R01324,R01325,R01900,R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170,R10501	RC00497,RC00498,RC00618,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iHN637.CLJU_RS04465,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
HKD1_k127_5198991_23	1499967.BAYZ01000028_gene1284	6.071e-64	223.0	COG0066@1|root,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_5198991_16	269799.Gmet_1927	1.37e-82	289.0	COG4395@1|root,COG4395@2|Bacteria,1NSUG@1224|Proteobacteria,42R4J@68525|delta/epsilon subdivisions,2WMXH@28221|Deltaproteobacteria,43UGP@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Tim44	-	-	-	-	-	-	-	-	-	-	-	-	DUF1517,Tim44
HKD1_k127_5198991_34	1267533.KB906735_gene4913	5.533e-13	69.0	COG2265@1|root,COG2265@2|Bacteria,3Y3SF@57723|Acidobacteria,2JI9H@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_5222180_8	867903.ThesuDRAFT_01405	8.619e-08	54.0	298S5@1|root,313VY@2|Bacteria,1U9KD@1239|Firmicutes,25702@186801|Clostridia	186801|Clostridia	S	Protein of unknown function with PCYCGC motif	-	-	-	-	-	-	-	-	-	-	-	-	PCYCGC
HKD1_k127_5222180_4	653733.Selin_0567	1.005e-25	113.0	COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	vnfA	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding
HKD1_k127_5222180_2	118005.AWNK01000010_gene335	4.241e-129	432.0	COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	vnfA	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding
HKD1_k127_5222180_5	118005.AWNK01000010_gene334	6.309e-24	115.0	COG4633@1|root,COG4633@2|Bacteria	2|Bacteria	-	-	silP	-	1.9.3.1,3.6.3.54	ko:K02275,ko:K17686	ko00190,ko01100,ko01524,ko04016,map00190,map01100,map01524,map04016	M00155	R00081,R00086	RC00002,RC00016	ko00000,ko00001,ko00002,ko01000	3.A.3.5,3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,DsbD_2,HMA
HKD1_k127_5222180_6	926550.CLDAP_38270	1.074e-14	86.0	COG2010@1|root,COG2010@2|Bacteria,2G741@200795|Chloroflexi	200795|Chloroflexi	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cytochrome_CBB3
HKD1_k127_5222180_3	338969.Rfer_2853	1.895e-55	199.0	2CP7W@1|root,32MRP@2|Bacteria,1Q5NY@1224|Proteobacteria,2VYCY@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5222180_7	452637.Oter_4454	8.56e-14	73.0	COG2820@1|root,COG2820@2|Bacteria	2|Bacteria	F	uridine phosphorylase activity	-	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_5222180_0	1041146.ATZB01000034_gene559	8.315e-185	584.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,4BD23@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_5222180_1	666684.AfiDRAFT_0764	1.56e-161	519.0	COG0477@1|root,COG2814@2|Bacteria,1R2KY@1224|Proteobacteria,2TR2U@28211|Alphaproteobacteria,3JXR6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_5222180_9	272560.BPSS2119	0.0001857	44.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VP0A@28216|Betaproteobacteria,1K90G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_5232907_1	204669.Acid345_4072	1.438e-118	400.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria,2JHZY@204432|Acidobacteriia	204432|Acidobacteriia	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_5232907_0	1304885.AUEY01000002_gene358	0.0	1289.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_5232907_2	56780.SYN_02948	3.632e-58	211.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42Q4P@68525|delta/epsilon subdivisions,2WJHQ@28221|Deltaproteobacteria,2MR8F@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_523324_1	1121028.ARQE01000008_gene2361	1.051e-33	134.0	COG5642@1|root,COG5642@2|Bacteria,1RK9F@1224|Proteobacteria,2UA8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HKD1_k127_523324_0	1380391.JIAS01000013_gene3866	4.423e-67	233.0	COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,2U76F@28211|Alphaproteobacteria,2JTYN@204441|Rhodospirillales	204441|Rhodospirillales	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD1_k127_523324_3	1156919.QWC_02234	4.698e-10	64.0	COG2030@1|root,COG2030@2|Bacteria,1NAYM@1224|Proteobacteria,2WAUD@28216|Betaproteobacteria,3T73N@506|Alcaligenaceae	28216|Betaproteobacteria	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N
HKD1_k127_523324_2	936455.KI421499_gene6576	3.439e-15	80.0	COG2030@1|root,COG2030@2|Bacteria,1NAYM@1224|Proteobacteria,2TRU0@28211|Alphaproteobacteria,3K1UM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD1_k127_523324_4	1173026.Glo7428_3891	7.295e-09	58.0	29GXU@1|root,303VH@2|Bacteria,1G757@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5245889_1	909663.KI867150_gene2687	2.899e-48	176.0	COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42QCR@68525|delta/epsilon subdivisions,2WIP7@28221|Deltaproteobacteria,2MQDZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
HKD1_k127_5245889_2	765952.PUV_26370	1.078e-34	137.0	2E3V1@1|root,32YSA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5245889_0	1300345.LF41_901	1.908e-116	395.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_5252524_2	1038869.AXAN01000144_gene2939	7.551e-32	128.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2VPGV@28216|Betaproteobacteria,1K2CQ@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Elements of external origin	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_5252524_0	1057002.KB905372_gene5965	3.856e-127	415.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_5252524_1	1121106.JQKB01000246_gene5008	5.422e-64	221.0	COG3293@1|root,COG3293@2|Bacteria,1PVIT@1224|Proteobacteria,2TURP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD1_k127_5253176_2	1203611.KB894544_gene2011	0.0003338	46.0	COG0778@1|root,COG0778@2|Bacteria,4NXTZ@976|Bacteroidetes,2FR4E@200643|Bacteroidia	976|Bacteroidetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_5253176_0	1005048.CFU_1643	1.359e-127	415.0	COG0596@1|root,COG0596@2|Bacteria,1MWT6@1224|Proteobacteria,2VHJW@28216|Betaproteobacteria,475ZN@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_5253176_1	225400.XP_006762957.1	0.0002115	47.0	COG0666@1|root,KOG4177@2759|Eukaryota,38BVK@33154|Opisthokonta,3BGGV@33208|Metazoa,3CT1S@33213|Bilateria,482US@7711|Chordata,49452@7742|Vertebrata,3JPKJ@40674|Mammalia,4KRFU@9397|Chiroptera	33208|Metazoa	M	ZU5 domain	ANK2	GO:0000902,GO:0000904,GO:0001508,GO:0002027,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003205,GO:0003230,GO:0003279,GO:0003283,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0005911,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0006873,GO:0006874,GO:0006875,GO:0006888,GO:0006928,GO:0006935,GO:0006936,GO:0006937,GO:0006941,GO:0006942,GO:0007009,GO:0007154,GO:0007165,GO:0007267,GO:0007275,GO:0007399,GO:0007409,GO:0007411,GO:0007507,GO:0008015,GO:0008016,GO:0008092,GO:0008104,GO:0008150,GO:0009605,GO:0009653,GO:0009893,GO:0009987,GO:0010171,GO:0010256,GO:0010468,GO:0010522,GO:0010604,GO:0010628,GO:0010646,GO:0010880,GO:0010881,GO:0010882,GO:0010959,GO:0014069,GO:0014704,GO:0015459,GO:0016020,GO:0016021,GO:0016043,GO:0016192,GO:0016247,GO:0016323,GO:0016328,GO:0019222,GO:0019722,GO:0019725,GO:0019899,GO:0019900,GO:0019901,GO:0019932,GO:0022008,GO:0022898,GO:0023051,GO:0023052,GO:0030001,GO:0030003,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030030,GO:0030048,GO:0030054,GO:0030154,GO:0030182,GO:0030315,GO:0030507,GO:0030674,GO:0031175,GO:0031224,GO:0031226,GO:0031430,GO:0031647,GO:0031672,GO:0031674,GO:0032279,GO:0032409,GO:0032411,GO:0032412,GO:0032414,GO:0032501,GO:0032502,GO:0032879,GO:0032970,GO:0032989,GO:0032990,GO:0033036,GO:0033292,GO:0033365,GO:0033563,GO:0034394,GO:0034613,GO:0034762,GO:0034764,GO:0034765,GO:0034767,GO:0035556,GO:0035637,GO:0036309,GO:0036371,GO:0040008,GO:0040011,GO:0040014,GO:0040018,GO:0042221,GO:0042330,GO:0042383,GO:0042391,GO:0042592,GO:0042692,GO:0043034,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043266,GO:0043268,GO:0043269,GO:0043270,GO:0043292,GO:0044057,GO:0044093,GO:0044291,GO:0044325,GO:0044422,GO:0044424,GO:0044425,GO:0044444,GO:0044449,GO:0044456,GO:0044459,GO:0044464,GO:0045202,GO:0045927,GO:0046907,GO:0048193,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048522,GO:0048638,GO:0048639,GO:0048666,GO:0048667,GO:0048699,GO:0048731,GO:0048812,GO:0048856,GO:0048858,GO:0048869,GO:0048878,GO:0050789,GO:0050793,GO:0050794,GO:0050801,GO:0050821,GO:0050839,GO:0050896,GO:0051049,GO:0051050,GO:0051094,GO:0051117,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051270,GO:0051279,GO:0051282,GO:0051641,GO:0051649,GO:0051716,GO:0051899,GO:0051924,GO:0051928,GO:0055001,GO:0055065,GO:0055074,GO:0055080,GO:0055082,GO:0055117,GO:0060047,GO:0060048,GO:0060090,GO:0060255,GO:0060306,GO:0060307,GO:0060341,GO:0061024,GO:0061061,GO:0061337,GO:0061564,GO:0065007,GO:0065008,GO:0065009,GO:0070252,GO:0070296,GO:0070727,GO:0070838,GO:0070972,GO:0071840,GO:0071944,GO:0072359,GO:0072503,GO:0072507,GO:0072511,GO:0072657,GO:0072659,GO:0086001,GO:0086002,GO:0086003,GO:0086004,GO:0086005,GO:0086010,GO:0086012,GO:0086014,GO:0086015,GO:0086018,GO:0086019,GO:0086026,GO:0086036,GO:0086046,GO:0086065,GO:0086066,GO:0086070,GO:0086091,GO:0090257,GO:0097458,GO:0097485,GO:0098590,GO:0098771,GO:0098772,GO:0098794,GO:0098900,GO:0098901,GO:0098904,GO:0098907,GO:0098910,GO:0098984,GO:0099080,GO:0099081,GO:0099106,GO:0099512,GO:0099572,GO:0099623,GO:0120036,GO:0120039,GO:1901016,GO:1901018,GO:1901019,GO:1901021,GO:1901379,GO:1901381,GO:1903115,GO:1903169,GO:1903522,GO:1903779,GO:1904062,GO:1904064,GO:1904427,GO:1990778,GO:2001257,GO:2001259	-	ko:K10380,ko:K21440	ko04624,ko05205,map04624,map05205	-	-	-	ko00000,ko00001,ko04131,ko04812	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,Death,ZU5
HKD1_k127_5275313_3	483219.LILAB_36650	3.385e-18	93.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NRE@68525|delta/epsilon subdivisions,2WM0E@28221|Deltaproteobacteria,2Z32T@29|Myxococcales	28221|Deltaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_5275313_4	1211777.BN77_p40032	6.366e-05	55.0	COG2801@1|root,COG2801@2|Bacteria,1MXKK@1224|Proteobacteria,2TTM6@28211|Alphaproteobacteria,4BF3D@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	PFAM Integrase	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_5275313_5	483219.LILAB_36650	0.0008996	43.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,42NRE@68525|delta/epsilon subdivisions,2WM0E@28221|Deltaproteobacteria,2Z32T@29|Myxococcales	28221|Deltaproteobacteria	L	COG1484 DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_5275313_1	1379698.RBG1_1C00001G0858	3.186e-89	308.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HKD1_k127_5275313_0	1379698.RBG1_1C00001G0858	1.035e-99	344.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HKD1_k127_5275313_2	1379698.RBG1_1C00001G0857	3.084e-41	156.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5286781_2	1121468.AUBR01000015_gene2284	5.275e-08	54.0	COG0243@1|root,COG0243@2|Bacteria,1TPZG@1239|Firmicutes,247JV@186801|Clostridia,42FAC@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	1.8.5.5,1.8.5.6	ko:K08352,ko:K21307	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R10149,R11487	RC00168,RC02823	ko00000,ko00001,ko01000,ko02000	5.A.3.5	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding,TAT_signal
HKD1_k127_5286781_1	1121405.dsmv_0053	7.595e-82	275.0	COG0437@1|root,COG0437@2|Bacteria,1MU5T@1224|Proteobacteria,42R9D@68525|delta/epsilon subdivisions,2WN5Q@28221|Deltaproteobacteria,2MJN0@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_4,Fer4_7
HKD1_k127_5286781_0	1121405.dsmv_0054	1.185e-212	673.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1MU2H@1224|Proteobacteria,42M6X@68525|delta/epsilon subdivisions,2X6YD@28221|Deltaproteobacteria,2MHMN@213118|Desulfobacterales	28221|Deltaproteobacteria	E	PFAM Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD1_k127_5291004_0	1347369.CCAD010000083_gene2765	3.708e-123	412.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,4HFIP@91061|Bacilli,1ZD3I@1386|Bacillus	1239|Firmicutes	C	COG2414 Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_5291004_1	47763.JNZA01000003_gene3903	3.083e-28	118.0	COG1846@1|root,COG1846@2|Bacteria,2IBDP@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_5302266_2	1116472.MGMO_55c00010	4.146e-60	223.0	COG3568@1|root,COG3568@2|Bacteria,1N29G@1224|Proteobacteria	1224|Proteobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_5302266_0	234267.Acid_7271	1.471e-278	880.0	COG0421@1|root,COG0421@2|Bacteria,3Y6UP@57723|Acidobacteria	57723|Acidobacteria	E	Spermine/spermidine synthase domain	-	-	-	-	-	-	-	-	-	-	-	-	Spermine_synth
HKD1_k127_5302266_1	671143.DAMO_1577	6.146e-215	677.0	COG1690@1|root,COG1690@2|Bacteria,2NNVX@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the RtcB family	rtcB	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD1_k127_5302266_3	580332.Slit_1822	1.971e-18	89.0	COG2165@1|root,COG2165@2|Bacteria,1MZ5I@1224|Proteobacteria,2VU7P@28216|Betaproteobacteria,44WII@713636|Nitrosomonadales	28216|Betaproteobacteria	NU	Type II secretory pathway, pseudopilin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5302609_4	1379698.RBG1_1C00001G0689	1.498e-14	77.0	2DTPF@1|root,33M68@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HKD1_k127_5302609_2	1499967.BAYZ01000181_gene4487	2.691e-73	257.0	COG0646@1|root,COG0646@2|Bacteria,2NP9A@2323|unclassified Bacteria	2|Bacteria	E	Homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HKD1_k127_5302609_3	404380.Gbem_0282	1.573e-68	251.0	COG4191@1|root,COG4191@2|Bacteria,1R5Q1@1224|Proteobacteria,42TFH@68525|delta/epsilon subdivisions,2WPEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase HAMP	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_5302609_1	1125863.JAFN01000001_gene2253	1.447e-117	393.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_5302609_0	552811.Dehly_0927	2.091e-168	551.0	COG0543@1|root,COG2204@1|root,COG0543@2|Bacteria,COG2204@2|Bacteria,2G7HU@200795|Chloroflexi	200795|Chloroflexi	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.3	ko:K15765	ko00623,ko00920,ko01100,ko01120,ko01220,map00623,map00920,map01100,map01120,map01220	M00538	R02550,R03562,R05666,R09513	RC00269,RC00490,RC02556	ko00000,ko00001,ko00002,ko01000	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD1_k127_5302922_1	347834.RHE_CH02960	5.903e-134	436.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,2UPNC@28211|Alphaproteobacteria,4BARS@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_5302922_0	1041146.ATZB01000051_gene1045	6.041e-171	559.0	COG2199@1|root,COG4192@1|root,COG5002@1|root,COG3706@2|Bacteria,COG4192@2|Bacteria,COG5002@2|Bacteria,1R7HC@1224|Proteobacteria,2TZD4@28211|Alphaproteobacteria,4BP1D@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,PAS_7,Response_reg
HKD1_k127_5338674_38	234267.Acid_3589	5.507e-11	66.0	COG1044@1|root,COG1044@2|Bacteria,3Y2JC@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HKD1_k127_5338674_35	398767.Glov_0761	7.846e-18	94.0	COG2825@1|root,COG2825@2|Bacteria,1QMYZ@1224|Proteobacteria,43EVR@68525|delta/epsilon subdivisions,2WRG8@28221|Deltaproteobacteria,43VH1@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD1_k127_5338674_5	671143.DAMO_1653	1.259e-220	708.0	COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	bamA	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_5338674_0	671143.DAMO_1654	0.0	1307.0	COG0542@1|root,COG0542@2|Bacteria,2NNKN@2323|unclassified Bacteria	2|Bacteria	O	C-terminal, D2-small domain, of ClpB protein	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD1_k127_5338674_22	671143.DAMO_1655	3.991e-78	267.0	COG1136@1|root,COG1136@2|Bacteria,2NP7F@2323|unclassified Bacteria	2|Bacteria	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD1_k127_5338674_13	243231.GSU2270	1.047e-119	399.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,42MV0@68525|delta/epsilon subdivisions,2WITK@28221|Deltaproteobacteria,43T9B@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_5338674_6	671143.DAMO_1657	1.603e-200	637.0	COG1190@1|root,COG1190@2|Bacteria,2NNMH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006430,GO:0006518,GO:0006520,GO:0006629,GO:0006644,GO:0006650,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009059,GO:0009405,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019637,GO:0019752,GO:0030312,GO:0030322,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0040007,GO:0042221,GO:0042391,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044419,GO:0044424,GO:0044444,GO:0044464,GO:0046471,GO:0046483,GO:0046486,GO:0046677,GO:0046872,GO:0050896,GO:0051704,GO:0065007,GO:0065008,GO:0071704,GO:0071944,GO:0090304,GO:0090407,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF1260.b4129,iECDH1ME8569_1439.ECDH1ME8569_3989,iECW_1372.ECW_m4490,iEcDH1_1363.EcDH1_3862,iJN678.lysS,iJO1366.b4129,iWFL_1372.ECW_m4490	DUF2156,tRNA-synt_2,tRNA-synt_2_TM,tRNA_anti-codon
HKD1_k127_5338674_34	1288494.EBAPG3_10110	1.871e-25	109.0	2BW7N@1|root,32Z97@2|Bacteria,1P2ZF@1224|Proteobacteria,2W4Y3@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5338674_10	671143.DAMO_0677	3.639e-135	439.0	COG1186@1|root,COG1186@2|Bacteria,2NNU3@2323|unclassified Bacteria	2|Bacteria	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	GO:0003674,GO:0003676,GO:0003723,GO:0003747,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0016149,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_5338674_12	671143.DAMO_0676	1.558e-128	430.0	COG0815@1|root,COG0815@2|Bacteria,2NP0R@2323|unclassified Bacteria	2|Bacteria	M	Carbon-nitrogen hydrolase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD1_k127_5338674_28	671143.DAMO_0675	2.968e-58	212.0	COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_5338674_24	671143.DAMO_0674	1.557e-71	245.0	COG0233@1|root,COG0233@2|Bacteria,2NPEP@2323|unclassified Bacteria	2|Bacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	GO:0002181,GO:0002184,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0008079,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0030312,GO:0032984,GO:0034641,GO:0034645,GO:0040007,GO:0043021,GO:0043023,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD1_k127_5338674_17	671143.DAMO_0673	6.07e-109	358.0	COG0528@1|root,COG0528@2|Bacteria,2NNRY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006225,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009163,GO:0009165,GO:0009185,GO:0009188,GO:0009193,GO:0009194,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0033862,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042455,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046048,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046872,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iSB619.SA_RS06240	AA_kinase
HKD1_k127_5338674_25	546271.Selsp_0516	1.154e-70	250.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,4H35I@909932|Negativicutes	909932|Negativicutes	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD1_k127_5338674_19	671143.DAMO_0671	6.017e-99	333.0	COG0052@1|root,COG0052@2|Bacteria,2NP4M@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS2 family	rpsB	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_5338674_15	671143.DAMO_0669	1.801e-117	390.0	COG1364@1|root,COG1364@2|Bacteria,2NQKS@2323|unclassified Bacteria	2|Bacteria	E	ArgJ family	argJ	GO:0003674,GO:0003824,GO:0004042,GO:0004358,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006592,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.1,2.3.1.35,2.7.2.8	ko:K00620,ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1783	ArgJ
HKD1_k127_5338674_11	671143.DAMO_0668	1.642e-129	422.0	COG0002@1|root,COG0002@2|Bacteria,2NNN5@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily	argC	GO:0003674,GO:0003824,GO:0003942,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016491,GO:0016620,GO:0016903,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.2.1.38	ko:K00145,ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00028,M00031,M00763,M00845	R03443,R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1782,iSSON_1240.SSON_4131,iYO844.BSU11190	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_5338674_30	671143.DAMO_0667	1.616e-49	179.0	COG0103@1|root,COG0103@2|Bacteria,2NPN8@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_5338674_29	247639.MGP2080_15664	2.076e-53	193.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0070180,GO:0071704,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_5338674_37	639282.DEFDS_0505	2.616e-11	72.0	2CDR8@1|root,32ZSF@2|Bacteria,2GFUR@200930|Deferribacteres	200930|Deferribacteres	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5338674_27	240292.Ava_4653	1.978e-63	223.0	COG1905@1|root,COG1905@2|Bacteria,1G54V@1117|Cyanobacteria,1HRBV@1161|Nostocales	1117|Cyanobacteria	C	Thioredoxin-like [2Fe-2S] ferredoxin	hoxE	-	1.6.5.3	ko:K05586	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx
HKD1_k127_5338674_1	118163.Ple7327_0798	8.799e-268	832.0	COG1894@1|root,COG1894@2|Bacteria,1G2KY@1117|Cyanobacteria,3VISN@52604|Pleurocapsales	1117|Cyanobacteria	C	NADH ubiquinone oxidoreductase NADH-binding (51 kD) subunit	hoxF	-	1.6.5.3	ko:K05587	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	2Fe-2S_thioredx,Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_5338674_14	1173024.KI912151_gene2195	2.242e-119	388.0	COG3383@1|root,COG3383@2|Bacteria,1G3GD@1117|Cyanobacteria,1JKM7@1189|Stigonemataceae	1117|Cyanobacteria	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	hoxU	-	1.6.5.3	ko:K05588	ko00190,ko01100,map00190,map01100	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Fer4_9,NADH-G_4Fe-4S_3
HKD1_k127_5338674_26	232348.ADXL01000051_gene2219	8.441e-67	231.0	COG1941@1|root,COG1941@2|Bacteria,1G2I6@1117|Cyanobacteria,1H097@1129|Synechococcus	1117|Cyanobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hoxY	-	1.12.1.2	ko:K18007	-	-	-	-	ko00000,ko01000	-	-	iJN678.hoxY	Oxidored_q6
HKD1_k127_5338674_3	1173024.KI912151_gene2192	2.778e-246	767.0	COG3259@1|root,COG3259@2|Bacteria,1G1C8@1117|Cyanobacteria,1JK5U@1189|Stigonemataceae	1117|Cyanobacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	iJN678.hoxH	NiFeSe_Hases
HKD1_k127_5338674_33	1173024.KI912151_gene2190	2.833e-29	126.0	COG0680@1|root,COG0680@2|Bacteria,1G7PP@1117|Cyanobacteria,1JM0X@1189|Stigonemataceae	1117|Cyanobacteria	C	TIGRFAM hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5338674_4	338966.Ppro_2790	1.222e-244	774.0	COG3383@1|root,COG3383@2|Bacteria,1QTZB@1224|Proteobacteria,42SPZ@68525|delta/epsilon subdivisions,2WIV9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nuoG-1	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3349	Fer2_4,Fer4_10,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD1_k127_5338674_9	338966.Ppro_2789	4.295e-142	491.0	COG1150@1|root,COG1150@2|Bacteria,1QWNB@1224|Proteobacteria,43BTA@68525|delta/epsilon subdivisions,2X741@28221|Deltaproteobacteria,43VYT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HKD1_k127_5338674_16	338966.Ppro_2788	6.695e-114	378.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,42MVW@68525|delta/epsilon subdivisions,2WKKC@28221|Deltaproteobacteria,43UVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM oxidoreductase FAD NAD(P)-binding domain protein	hdrF	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD1_k127_5338674_32	338966.Ppro_2796	2.442e-36	154.0	COG0680@1|root,COG0680@2|Bacteria	2|Bacteria	C	spore germination	-	-	3.4.23.51	ko:K00442,ko:K08315	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000,ko01002	-	-	-	HycI
HKD1_k127_5338674_8	338966.Ppro_2787	1.851e-165	551.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,42NFV@68525|delta/epsilon subdivisions,2WJZ0@28221|Deltaproteobacteria,43T2H@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD1_k127_5338674_2	338966.Ppro_2786	1.136e-256	817.0	COG0852@1|root,COG3261@1|root,COG0852@2|Bacteria,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,43DST@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM NADH-ubiquinone oxidoreductase, chain 49kDa	hycE	GO:0003674,GO:0005488,GO:0016151,GO:0043167,GO:0043169,GO:0046872,GO:0046914	1.6.5.3	ko:K00333,ko:K12142,ko:K15830	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iECED1_1282.ECED1_3172,iEcE24377_1341.EcE24377A_2769,iYL1228.KPN_03058	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_5338674_18	338966.Ppro_2785	1.068e-107	357.0	COG0650@1|root,COG0650@2|Bacteria,1QUK1@1224|Proteobacteria,42PHN@68525|delta/epsilon subdivisions,2WKPJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM respiratory-chain NADH dehydrogenase, subunit 1	-	-	-	ko:K14087	-	-	-	-	ko00000	-	-	-	NADHdh
HKD1_k127_5338674_23	338966.Ppro_2784	1.055e-77	271.0	COG1143@1|root,COG1143@2|Bacteria,1R9YT@1224|Proteobacteria,42P0W@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hyfH	-	-	ko:K12143,ko:K15831	-	-	-	-	ko00000	-	-	iAPECO1_1312.APECO1_3805,iECABU_c1320.ECABU_c29910,iECED1_1282.ECED1_3171,iECOK1_1307.ECOK1_3094,iUMN146_1321.UM146_02980,iUTI89_1310.UTI89_C3083,ic_1306.c3280	Fer4,Fer4_7
HKD1_k127_5338674_20	338966.Ppro_2783	2.946e-92	305.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42NH3@68525|delta/epsilon subdivisions,2WNT3@28221|Deltaproteobacteria	1224|Proteobacteria	C	Belongs to the complex I 20 kDa subunit family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_5338674_31	644282.Deba_0317	1.752e-46	179.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_5338674_7	1125863.JAFN01000001_gene2739	1.417e-183	580.0	COG0426@1|root,COG0426@2|Bacteria,1NDXY@1224|Proteobacteria,42N11@68525|delta/epsilon subdivisions,2WJ8Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	flavodoxin nitric oxide synthase	roo	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
HKD1_k127_5338674_36	273068.TTE2154	7.957e-18	85.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,42H59@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD1_k127_5338674_21	448385.sce2591	5.215e-81	279.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,437Y3@68525|delta/epsilon subdivisions,2X380@28221|Deltaproteobacteria,2YURY@29|Myxococcales	28221|Deltaproteobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_5355053_2	671143.DAMO_2494	2.446e-29	118.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_5355053_0	404380.Gbem_3986	4.588e-148	479.0	COG0477@1|root,COG2814@2|Bacteria,1NE49@1224|Proteobacteria,42PR8@68525|delta/epsilon subdivisions,2WK8J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_5355053_1	1121430.JMLG01000006_gene1775	1.443e-123	407.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,261AH@186807|Peptococcaceae	186801|Clostridia	J	SAM-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
HKD1_k127_5379905_0	335543.Sfum_0590	2.36e-59	211.0	2BQW2@1|root,32JT0@2|Bacteria,1QNFB@1224|Proteobacteria,432XH@68525|delta/epsilon subdivisions,2WYDA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5379905_1	1121405.dsmv_1062	3.642e-26	111.0	COG0451@1|root,COG2133@1|root,COG0451@2|Bacteria,COG2133@2|Bacteria,1R2HQ@1224|Proteobacteria,42ZN7@68525|delta/epsilon subdivisions,2WUV4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	PFAM Di-glucose binding within endoplasmic reticulum	-	-	-	-	-	-	-	-	-	-	-	-	Malectin
HKD1_k127_5381168_7	997296.PB1_14569	2.624e-63	232.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,4HAPA@91061|Bacilli,1ZBBG@1386|Bacillus	91061|Bacilli	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_5381168_6	247490.KSU1_B0116	2.073e-71	261.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5381168_9	13616.ENSMODP00000000315	4.669e-08	66.0	KOG3544@1|root,KOG3544@2759|Eukaryota,391UJ@33154|Opisthokonta,3BD1G@33208|Metazoa,3CY77@33213|Bilateria,47ZWT@7711|Chordata,48VJY@7742|Vertebrata,3J8EP@40674|Mammalia,4K8GI@9263|Metatheria	33208|Metazoa	W	Fibrillar collagens C-terminal domain	COL24A1	GO:0002244,GO:0002376,GO:0002520,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005788,GO:0007275,GO:0008150,GO:0009987,GO:0012505,GO:0030097,GO:0030154,GO:0031974,GO:0032501,GO:0032502,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0048513,GO:0048534,GO:0048731,GO:0048856,GO:0048869,GO:0070013	-	ko:K19721	ko04974,map04974	-	-	-	ko00000,ko00001,ko00536	-	-	-	COLFI,Collagen,Laminin_G_2
HKD1_k127_5381168_5	1123368.AUIS01000004_gene120	2.168e-76	287.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1NWNJ@1224|Proteobacteria,1T2K7@1236|Gammaproteobacteria,2NDJ6@225057|Acidithiobacillales	1236|Gammaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Phosphonate-bd
HKD1_k127_5381168_1	215803.DB30_8572	4.219e-219	687.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,42UR5@68525|delta/epsilon subdivisions,2WQET@28221|Deltaproteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 1 family	bglA	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD1_k127_5381168_2	215803.DB30_8576	3.176e-198	630.0	COG5368@1|root,COG5368@2|Bacteria,1NX2K@1224|Proteobacteria	1224|Proteobacteria	N	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Glycoamylase
HKD1_k127_5381168_3	215803.DB30_8575	1.733e-174	556.0	COG1653@1|root,COG1653@2|Bacteria,1MX59@1224|Proteobacteria	1224|Proteobacteria	G	ABC transporter substrate-binding protein	malE	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_5381168_4	84531.JMTZ01000011_gene3093	5.834e-138	444.0	COG1175@1|root,COG1175@2|Bacteria,1MVAP@1224|Proteobacteria,1S6CY@1236|Gammaproteobacteria,1X3CM@135614|Xanthomonadales	135614|Xanthomonadales	P	ABC-type sugar transport systems, permease components	lacF	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5381168_8	1416759.AYMR01000006_gene1349	1.36e-58	213.0	COG0395@1|root,COG0395@2|Bacteria,2GITV@201174|Actinobacteria,4FTGA@85023|Microbacteriaceae	201174|Actinobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10119	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1
HKD1_k127_5381168_0	935863.AWZR01000003_gene2771	0.0	1140.0	COG3408@1|root,COG3408@2|Bacteria,1QU1Q@1224|Proteobacteria,1RRX2@1236|Gammaproteobacteria,1X4YN@135614|Xanthomonadales	135614|Xanthomonadales	G	coagulation factor 5 8 type	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,F5_F8_type_C,GDE_C
HKD1_k127_5385534_5	265072.Mfla_1690	8.978e-19	89.0	2DNS2@1|root,32YVY@2|Bacteria,1N9QQ@1224|Proteobacteria,2VY3B@28216|Betaproteobacteria,2KNXC@206350|Nitrosomonadales	206350|Nitrosomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5385534_0	1122963.AUHB01000008_gene3431	0.0	1412.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,36Z9W@31993|Methylocystaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K21134	-	M00821	-	-	ko00000,ko00002,ko02000	2.A.6.2.27	-	-	ACR_tran
HKD1_k127_5385534_2	395964.KE386496_gene2794	4.81e-119	397.0	COG0845@1|root,COG0845@2|Bacteria,1PVWV@1224|Proteobacteria,2TTJX@28211|Alphaproteobacteria,3NAHC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_5385534_3	1079460.ATTQ01000002_gene5324	1.377e-67	237.0	COG1309@1|root,COG1309@2|Bacteria,1PH1P@1224|Proteobacteria,2V7Y4@28211|Alphaproteobacteria,4BH92@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_7,TetR_N
HKD1_k127_5385534_1	485913.Krac_7449	1.592e-180	580.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_5385534_4	1469607.KK073765_gene6428	6.814e-48	183.0	COG1961@1|root,COG1961@2|Bacteria,1GCM6@1117|Cyanobacteria	1117|Cyanobacteria	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_5385534_7	1206731.BAGB01000063_gene7451	0.0001254	46.0	COG1961@1|root,COG1961@2|Bacteria,2ID9R@201174|Actinobacteria	201174|Actinobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_5385534_6	1192034.CAP_4530	2.632e-07	52.0	COG1073@1|root,COG1073@2|Bacteria,1MXJ3@1224|Proteobacteria,42S9Z@68525|delta/epsilon subdivisions,2WUXI@28221|Deltaproteobacteria,2YUKK@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_5394465_3	671143.DAMO_2301	3.517e-138	451.0	COG1181@1|root,COG1181@2|Bacteria,2NPB2@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4,6.3.2.8	ko:K01921,ko:K01924	ko00471,ko00473,ko00550,ko01100,ko01502,map00471,map00473,map00550,map01100,map01502	-	R01150,R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N,Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_5394465_1	671143.DAMO_2300	2.024e-149	480.0	COG0472@1|root,COG0472@2|Bacteria,2NNQW@2323|unclassified Bacteria	2|Bacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0040007,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iAF987.Gmet_0409,iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
HKD1_k127_5394465_2	671143.DAMO_2299	2e-143	468.0	COG0771@1|root,COG0771@2|Bacteria,2NP27@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008764,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0030203,GO:0034645,GO:0042546,GO:0042802,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iAPECO1_1312.APECO1_1898,iECNA114_1301.ECNA114_0081,iECOK1_1307.ECOK1_0089,iECP_1309.ECP_0090,iECS88_1305.ECS88_0091,iECSF_1327.ECSF_0098,iLF82_1304.LF82_1418,iNRG857_1313.NRG857_00450,iUMN146_1321.UM146_23225,iUTI89_1310.UTI89_C0097	Mur_ligase_C,Mur_ligase_M
HKD1_k127_5394465_4	671143.DAMO_2298	3.028e-110	373.0	COG0772@1|root,COG0772@2|Bacteria,2NP3P@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_5394465_5	671143.DAMO_2297	1.792e-100	342.0	COG0707@1|root,COG0707@2|Bacteria,2NP4Z@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008194,GO:0008375,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016740,GO:0016757,GO:0016758,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0050511,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	iLJ478.TM0232,iSFV_1184.SFV_0083,iSF_1195.SF0087,iSFxv_1172.SFxv_0091,iS_1188.S0089	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_5394465_0	671143.DAMO_2296	4.157e-197	623.0	COG0773@1|root,COG0773@2|Bacteria,2NNPU@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the MurCDEF family	murC	GO:0000166,GO:0000270,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008763,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034645,GO:0035639,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0046872,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	iECP_1309.ECP_0093,iJN678.murC	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_5394465_6	671143.DAMO_2295	2.395e-42	163.0	COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iIT341.HP1418,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845,iYO844.BSU15230	FAD_binding_4,MurB_C
HKD1_k127_5394645_18	1033743.CAES01000001_gene1722	1.016e-50	195.0	COG0673@1|root,COG0673@2|Bacteria,1V0IZ@1239|Firmicutes,4HF8U@91061|Bacilli,26V8C@186822|Paenibacillaceae	91061|Bacilli	S	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5394645_11	1038859.AXAU01000002_gene398	1.751e-102	341.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VFFM@28211|Alphaproteobacteria,3JYFJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5394645_8	1038859.AXAU01000002_gene399	2.79e-110	364.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2U351@28211|Alphaproteobacteria,3JUAH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5394645_6	1038859.AXAU01000002_gene400	2.459e-140	460.0	COG1653@1|root,COG1653@2|Bacteria,1PEBV@1224|Proteobacteria,2V8NU@28211|Alphaproteobacteria,3K0ZY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_5394645_27	1116369.KB890025_gene5357	1.055e-10	65.0	COG1942@1|root,COG1942@2|Bacteria,1NG98@1224|Proteobacteria,2UK0G@28211|Alphaproteobacteria,43QB4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_5394645_21	264732.Moth_0417	1.003e-45	178.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	kdgR	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HKD1_k127_5394645_12	665571.STHERM_c06130	6.343e-95	321.0	COG1638@1|root,COG1638@2|Bacteria,2J9TV@203691|Spirochaetes	203691|Spirochaetes	G	TIGRFAM TRAP dicarboxylate transporter, DctP subunit	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_5394645_14	1499967.BAYZ01000073_gene2031	7.96e-90	309.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_5394645_0	706587.Desti_3265	1.97e-169	546.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,42M32@68525|delta/epsilon subdivisions,2WJA4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_5394645_26	1245469.S58_27210	4.473e-12	75.0	2BKYI@1|root,32FF5@2|Bacteria,1RB6X@1224|Proteobacteria,2VER9@28211|Alphaproteobacteria,3JY0I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	MA20_15120	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_5394645_9	1123237.Salmuc_04919	3.27e-109	373.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MmgE PrpD family protein	MA20_23745	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_5394645_17	1219084.AP014508_gene380	7.285e-54	204.0	COG2358@1|root,COG2358@2|Bacteria	2|Bacteria	G	TRAP transporter, solute receptor (TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD1_k127_5394645_4	158189.SpiBuddy_1111	3.748e-145	481.0	COG4666@1|root,COG4666@2|Bacteria,2J57Z@203691|Spirochaetes	203691|Spirochaetes	S	TIGRFAM TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5394645_25	1205680.CAKO01000037_gene1183	1.011e-14	88.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,2U9SM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	PFAM NIPSNAP family containing protein	MA20_41850	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HKD1_k127_5394645_2	1499967.BAYZ01000078_gene1003	9.426e-150	496.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_5394645_28	1205680.CAKO01000037_gene1301	3.768e-06	55.0	2CQ1K@1|root,32SKA@2|Bacteria	2|Bacteria	S	membrane	MA20_15810	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_5394645_7	1499967.BAYZ01000078_gene1005	6.106e-119	391.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_5394645_24	1499967.BAYZ01000163_gene6590	5.575e-24	110.0	2DTSB@1|root,33MG4@2|Bacteria	2|Bacteria	S	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_5394645_5	1528106.JRJE01000021_gene32	8.051e-142	464.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,2TQW5@28211|Alphaproteobacteria,2JQGA@204441|Rhodospirillales	204441|Rhodospirillales	G	COG1593 TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5394645_10	1528106.JRJE01000021_gene33	4.921e-105	351.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2U4IT@28211|Alphaproteobacteria,2JX4W@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_5394645_23	158189.SpiBuddy_2525	5.453e-40	154.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5394645_16	234267.Acid_2736	2.732e-61	222.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD1_k127_5394645_22	264732.Moth_1780	1.487e-42	166.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HKD1_k127_5394645_20	555079.Toce_0385	1.569e-46	177.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,42G3H@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator IclR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD1_k127_5394645_3	1411123.JQNH01000001_gene58	2.612e-146	474.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria,2TTT8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	TRAP-type C4-dicarboxylate transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_5394645_19	416591.Tlet_0053	6.521e-49	179.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_5394645_1	416591.Tlet_0052	5.776e-164	526.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5394645_13	1499967.BAYZ01000052_gene4664	2.702e-92	319.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_5394645_15	1499967.BAYZ01000076_gene767	1.151e-77	267.0	COG1175@1|root,COG1175@2|Bacteria,2NPAH@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
HKD1_k127_5404058_2	378806.STAUR_6021	1.422e-05	53.0	2AGWF@1|root,3174U@2|Bacteria,1PYDK@1224|Proteobacteria,435AC@68525|delta/epsilon subdivisions,2WZMD@28221|Deltaproteobacteria,2Z2DC@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5404058_0	926549.KI421517_gene3501	3.121e-60	223.0	COG0457@1|root,COG0457@2|Bacteria,4P246@976|Bacteroidetes,47ME2@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911,TPR_8
HKD1_k127_5410414_0	671143.DAMO_2942	2.959e-124	411.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD1_k127_5410414_2	1197906.CAJQ02000027_gene1525	1.443e-05	53.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JV1X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_5410414_1	903818.KI912269_gene263	6.935e-22	105.0	COG4765@1|root,COG4765@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	-	-	-	ko:K07465	-	-	-	-	ko00000	-	-	-	DUF2155
HKD1_k127_5411476_0	411902.CLOBOL_05026	7.716e-81	290.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,222RJ@1506553|Lachnoclostridium	186801|Clostridia	G	COG COG1638 TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_5411476_1	411902.CLOBOL_05025	1.28e-38	152.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia	186801|Clostridia	E	creatinase	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_5439605_1	335543.Sfum_1373	1.729e-105	366.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,42M3T@68525|delta/epsilon subdivisions,2WIV8@28221|Deltaproteobacteria,2MQUY@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	electron transfer flavoprotein, alpha subunit	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
HKD1_k127_5439605_2	335543.Sfum_1372	3.06e-102	338.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,42RCI@68525|delta/epsilon subdivisions,2WM55@28221|Deltaproteobacteria,2MQDQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_5439605_0	335543.Sfum_1371	2.072e-190	600.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,42MK5@68525|delta/epsilon subdivisions,2WJ3Z@28221|Deltaproteobacteria,2MQ86@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Acyl-CoA dehydrogenase	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_5439605_4	1121422.AUMW01000002_gene2198	1.309e-10	65.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,260BR@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_5439605_3	439235.Dalk_3305	1.165e-18	86.0	COG0333@1|root,COG0333@2|Bacteria,1NGM1@1224|Proteobacteria,42XHF@68525|delta/epsilon subdivisions,2WSX6@28221|Deltaproteobacteria,2MMB1@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	GO:0003674,GO:0003735,GO:0005198	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_5439605_5	1485545.JQLW01000010_gene1599	0.0001071	44.0	COG1399@1|root,COG1399@2|Bacteria	2|Bacteria	K	metal-binding, possibly nucleic acid-binding protein	yceD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0040007,GO:0044424,GO:0044444,GO:0044464	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD1_k127_5440644_0	1121405.dsmv_3003	0.0	4399.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD1_k127_5440644_1	880072.Desac_0227	8.771e-25	115.0	COG4625@1|root,COG4625@2|Bacteria,1PGXY@1224|Proteobacteria,43A1I@68525|delta/epsilon subdivisions,2X26U@28221|Deltaproteobacteria,2MR3U@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	protein with a C-terminal OMP (outer membrane protein) domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5440671_2	1268072.PSAB_23710	2.071e-43	162.0	COG1176@1|root,COG1176@2|Bacteria,1TRUC@1239|Firmicutes,4HABA@91061|Bacilli,26TSA@186822|Paenibacillaceae	91061|Bacilli	P	spermidine putrescine	cysT7	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD1_k127_5440671_0	1268072.PSAB_23705	6.09e-91	310.0	COG1177@1|root,COG1177@2|Bacteria,1URBC@1239|Firmicutes,4HB65@91061|Bacilli,26QH1@186822|Paenibacillaceae	91061|Bacilli	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD1_k127_5440671_1	368408.Tpen_1553	6.441e-76	259.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPVK@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran
HKD1_k127_5446438_3	756272.Plabr_3735	3.57e-67	243.0	2ABPF@1|root,3115E@2|Bacteria,2J40E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5446438_0	671143.DAMO_1989	3.636e-120	400.0	COG0285@1|root,COG0285@2|Bacteria,2NP60@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the folylpolyglutamate synthase family	folC	GO:0003674,GO:0003824,GO:0004326,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006575,GO:0006725,GO:0006732,GO:0006760,GO:0006761,GO:0006807,GO:0008150,GO:0008152,GO:0008841,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042398,GO:0042558,GO:0042559,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046452,GO:0046483,GO:0046900,GO:0046901,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0166,iSB619.SA_RS08370	Mur_ligase_C,Mur_ligase_M
HKD1_k127_5446438_1	289376.THEYE_A0559	7.733e-106	352.0	COG0777@1|root,COG0777@2|Bacteria,3J0CK@40117|Nitrospirae	40117|Nitrospirae	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_5446438_7	671143.DAMO_2125	9.979e-43	162.0	COG0724@1|root,COG0724@2|Bacteria,2NPT0@2323|unclassified Bacteria	2|Bacteria	S	RNA recognition motif	rbpD	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_5446438_6	1173024.KI912149_gene6319	1.43e-57	209.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	ppaX_1	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_5446438_9	237368.SCABRO_01825	2.202e-10	69.0	COG1283@1|root,COG1283@2|Bacteria	2|Bacteria	P	sodium-dependent phosphate transmembrane transporter activity	nptA	-	-	ko:K14683	-	-	-	-	ko00000,ko02000,ko04147	2.A.58.1	-	-	Na_Pi_cotrans
HKD1_k127_5446438_2	926550.CLDAP_05980	1.098e-83	300.0	COG3842@1|root,COG3842@2|Bacteria,2G6S3@200795|Chloroflexi	200795|Chloroflexi	P	Belongs to the ABC transporter superfamily	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE_2
HKD1_k127_5446438_4	251221.35214857	3.653e-62	229.0	COG4149@1|root,COG4149@2|Bacteria,1G08P@1117|Cyanobacteria	1117|Cyanobacteria	P	molybdate ABC transporter, permease protein	modB	-	3.6.3.29	ko:K02017,ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,BPD_transp_1
HKD1_k127_5446438_5	909663.KI867150_gene1462	8.861e-61	222.0	COG0725@1|root,COG0725@2|Bacteria,1MVNA@1224|Proteobacteria,42MZE@68525|delta/epsilon subdivisions,2WKJB@28221|Deltaproteobacteria,2MQEW@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TIGRFAM molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iAF987.Gmet_0512	SBP_bac_11
HKD1_k127_5446438_8	391625.PPSIR1_04258	8.746e-33	130.0	COG2329@1|root,COG2329@2|Bacteria,1PXIB@1224|Proteobacteria,43DUY@68525|delta/epsilon subdivisions,2WYY3@28221|Deltaproteobacteria,2Z0WH@29|Myxococcales	28221|Deltaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_5458377_1	1121428.DESHY_10157___1	1.659e-14	74.0	COG1522@1|root,COG1522@2|Bacteria,1V6TH@1239|Firmicutes,24JH9@186801|Clostridia,260KT@186807|Peptococcaceae	186801|Clostridia	K	transcriptional regulator, AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HKD1_k127_5458377_0	760568.Desku_1514	1.218e-172	551.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,26072@186807|Peptococcaceae	186801|Clostridia	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_5509616_19	986075.CathTA2_0637	2.895e-14	78.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,4HE64@91061|Bacilli	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_5509616_8	1382356.JQMP01000001_gene1176	2.44e-86	299.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_5509616_18	525903.Taci_0475	1.597e-14	79.0	COG1977@1|root,COG1977@2|Bacteria,3TBJI@508458|Synergistetes	508458|Synergistetes	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_5509616_6	1499967.BAYZ01000041_gene2361	1.881e-103	347.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_5509616_2	1499967.BAYZ01000041_gene2359	1.255e-134	441.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5509616_17	1499967.BAYZ01000041_gene2360	1.816e-23	107.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_5509616_7	1499967.BAYZ01000181_gene4495	2.279e-87	301.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5509616_1	868595.Desca_2486	2.26e-157	515.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,2604P@186807|Peptococcaceae	186801|Clostridia	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_5509616_13	1144310.PMI07_006288	5.081e-37	143.0	COG5507@1|root,COG5507@2|Bacteria,1RH3Q@1224|Proteobacteria,2U9SM@28211|Alphaproteobacteria,4BG6S@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	NIPSNAP	MA20_41850	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HKD1_k127_5509616_14	552811.Dehly_0222	6.864e-35	144.0	COG0169@1|root,COG0169@2|Bacteria,2G6FG@200795|Chloroflexi,34CWQ@301297|Dehalococcoidia	301297|Dehalococcoidia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_dh_N
HKD1_k127_5509616_10	1499967.BAYZ01000041_gene2367	3.638e-64	225.0	COG0757@1|root,COG0757@2|Bacteria,2NPMW@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	GO:0003674,GO:0003824,GO:0003855,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019752,GO:0040007,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0071704,GO:1901576	3.4.13.9,4.2.1.10	ko:K01271,ko:K03785,ko:K03786,ko:K16021	ko00400,ko01051,ko01100,ko01110,ko01130,ko01230,map00400,map01051,map01100,map01110,map01130,map01230	M00022	R03084,R06593	RC00848	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iIT341.HP1038,iJN746.PP_0560,iLJ478.TM0349	DHquinase_II
HKD1_k127_5509616_0	1499967.BAYZ01000041_gene2368	2.072e-216	682.0	COG3333@1|root,COG3333@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_5509616_15	1499967.BAYZ01000041_gene2369	9.426e-26	112.0	2E4UV@1|root,32ZP8@2|Bacteria	2|Bacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_5509616_3	1499967.BAYZ01000041_gene2370	2.193e-131	428.0	COG3181@1|root,COG3181@2|Bacteria	2|Bacteria	E	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_5509616_12	66377.JOBH01000004_gene3736	1.58e-54	205.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria	201174|Actinobacteria	E	alcohol dehydrogenase	-	-	1.1.1.1,1.6.5.5	ko:K00001,ko:K00344	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD1_k127_5509616_4	180332.JTGN01000002_gene5723	2.729e-125	409.0	COG1402@1|root,COG1402@2|Bacteria,1V0N8@1239|Firmicutes,24BWG@186801|Clostridia	186801|Clostridia	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470,ko:K22232	ko00330,ko00562,map00330,map00562	-	R01884,R11771	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_5509616_21	794903.OPIT5_22680	2.549e-10	66.0	COG0662@1|root,COG0662@2|Bacteria,46XZG@74201|Verrucomicrobia,3K8P2@414999|Opitutae	414999|Opitutae	G	Protein of unknown function (DUF861)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5509616_5	1499967.BAYZ01000041_gene2362	1.843e-105	347.0	COG1028@1|root,COG1028@2|Bacteria	1499967.BAYZ01000041_gene2362|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5509616_9	1449126.JQKL01000020_gene3332	6.351e-79	277.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia	186801|Clostridia	C	Belongs to the LDH2 MDH2 oxidoreductase family	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_5509616_11	504472.Slin_4023	1.957e-55	205.0	COG0684@1|root,COG0684@2|Bacteria,4NHRR@976|Bacteroidetes,47KQ5@768503|Cytophagia	976|Bacteroidetes	H	Pfam:Methyltransf_6	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HKD1_k127_5509616_16	246194.CHY_0189	8.44e-25	113.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,42FBD@68295|Thermoanaerobacterales	186801|Clostridia	K	regulatory protein GntR HTH	ydfH_4	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_5509616_20	266117.Rxyl_2442	3.227e-14	80.0	COG1547@1|root,COG1547@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF309)	ypuF	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
HKD1_k127_5519588_1	909663.KI867150_gene2887	2.858e-217	682.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42N22@68525|delta/epsilon subdivisions,2WIMH@28221|Deltaproteobacteria,2MQBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_5519588_0	1210884.HG799469_gene14118	1.45e-321	1005.0	COG1523@1|root,COG1523@2|Bacteria,2IXJM@203682|Planctomycetes	203682|Planctomycetes	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_48
HKD1_k127_5519588_3	189753.AXAS01000088_gene3493	1.267e-19	95.0	2D8WY@1|root,32TS4@2|Bacteria,1N2W6@1224|Proteobacteria,2UDGB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5519588_2	1169143.KB911037_gene3943	4.884e-135	432.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2WHH3@28216|Betaproteobacteria,1KIP3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_5522122_2	1232410.KI421426_gene1482	8.152e-70	239.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,42M26@68525|delta/epsilon subdivisions,2WKQV@28221|Deltaproteobacteria,43V5R@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD1_k127_5522122_1	1267534.KB906760_gene1237	1.413e-232	733.0	COG0659@1|root,COG0659@2|Bacteria,3Y6R7@57723|Acidobacteria,2JM1A@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_5522122_4	240016.ABIZ01000001_gene349	1.391e-25	111.0	COG0355@1|root,COG0355@2|Bacteria,46T0F@74201|Verrucomicrobia,2IUNC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD1_k127_5522122_0	1156937.MFUM_970015	1.02e-236	740.0	COG0055@1|root,COG0055@2|Bacteria,46SCC@74201|Verrucomicrobia,37FV6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_5522122_3	497964.CfE428DRAFT_4490	1.875e-62	222.0	COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD1_k127_5547180_12	485916.Dtox_0789	2.749e-21	99.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,263E4@186807|Peptococcaceae	186801|Clostridia	T	response regulator receiver	-	-	-	ko:K02481,ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_5547180_6	243231.GSU2915	4.351e-151	498.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_5547180_10	1232410.KI421428_gene1053	1.902e-98	342.0	COG4191@1|root,COG4191@2|Bacteria,1N2VE@1224|Proteobacteria,43AY6@68525|delta/epsilon subdivisions,2X6CJ@28221|Deltaproteobacteria,43T05@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_5547180_2	234267.Acid_3373	2.717e-172	561.0	COG1282@1|root,COG1282@2|Bacteria,3Y42H@57723|Acidobacteria	57723|Acidobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD1_k127_5547180_11	234267.Acid_3374	3.295e-22	107.0	COG3288@1|root,COG3288@2|Bacteria,3Y5PH@57723|Acidobacteria	57723|Acidobacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD1_k127_5547180_8	671143.DAMO_0093	2.564e-115	383.0	COG3288@1|root,COG3288@2|Bacteria,2NQF3@2323|unclassified Bacteria	2|Bacteria	C	Alanine dehydrogenase/PNT, C-terminal domain	pntA	GO:0000166,GO:0003674,GO:0005488,GO:0036094,GO:0043167,GO:0043168,GO:0048037,GO:0050662,GO:0051287,GO:0070403,GO:0097159,GO:1901265,GO:1901363	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_5547180_1	945713.IALB_1306	9.348e-182	595.0	COG2864@1|root,COG2864@2|Bacteria	2|Bacteria	C	formate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD1_k127_5547180_13	768670.Calni_0644	4.999e-19	92.0	2DRRJ@1|root,33CRQ@2|Bacteria	2|Bacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_5547180_3	671143.DAMO_2715	2.956e-168	555.0	COG0001@1|root,COG0001@2|Bacteria,2NNV5@2323|unclassified Bacteria	2|Bacteria	H	PFAM aminotransferase class-III	hemL	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006082,GO:0006083,GO:0006091,GO:0006113,GO:0006520,GO:0006553,GO:0006554,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0015980,GO:0016020,GO:0016054,GO:0016740,GO:0016769,GO:0016853,GO:0016866,GO:0016869,GO:0016999,GO:0017144,GO:0018130,GO:0019438,GO:0019475,GO:0019477,GO:0019665,GO:0019666,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0033013,GO:0033014,GO:0034641,GO:0036094,GO:0040007,GO:0042168,GO:0042286,GO:0042440,GO:0042737,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044271,GO:0044281,GO:0044282,GO:0044464,GO:0046148,GO:0046395,GO:0046440,GO:0046483,GO:0046501,GO:0046983,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0070279,GO:0071704,GO:0071944,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	2.6.1.111,5.4.3.8	ko:K01845,ko:K21585	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272,R11607	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUMNK88_1353.UMNK88_158	Aminotran_3
HKD1_k127_5547180_4	671143.DAMO_2716	2.403e-160	513.0	COG0113@1|root,COG0113@2|Bacteria,2NNST@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ALAD family	hemB	GO:0000287,GO:0003674,GO:0003824,GO:0004655,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0030312,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iECABU_c1320.ECABU_c04500,iEcSMS35_1347.EcSMS35_0398,iJN746.PP_2913,ic_1306.c0477	ALAD
HKD1_k127_5547180_9	269797.Mbar_A1458	2.11e-103	349.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2N9ER@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_5547180_5	671143.DAMO_2717	2.814e-151	531.0	COG1452@1|root,COG1452@2|Bacteria,2NPN2@2323|unclassified Bacteria	2|Bacteria	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0006810,GO:0008150,GO:0008643,GO:0008645,GO:0009279,GO:0015267,GO:0015288,GO:0015749,GO:0015750,GO:0015751,GO:0015757,GO:0016020,GO:0019867,GO:0022803,GO:0022829,GO:0022857,GO:0030312,GO:0030313,GO:0031975,GO:0034219,GO:0044462,GO:0044464,GO:0046323,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:1904659	-	ko:K04744,ko:K09774,ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2,1.B.42.1	-	iAF987.Gmet_2474,iECO111_1330.ECO111_4695,iECSF_1327.ECSF_3725,iEcSMS35_1347.EcSMS35_4260	KdgM,OstA,OstA_2,OstA_C
HKD1_k127_5547180_0	671143.DAMO_2214	1.082e-294	925.0	COG4581@1|root,COG4581@2|Bacteria,2NPG6@2323|unclassified Bacteria	2|Bacteria	L	helicase superfamily c-terminal domain	helY	GO:0003674,GO:0003724,GO:0003824,GO:0004004,GO:0004386,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008026,GO:0008150,GO:0008152,GO:0008186,GO:0009056,GO:0009057,GO:0009987,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019439,GO:0030312,GO:0034641,GO:0034655,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0070035,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:1901360,GO:1901361,GO:1901575	-	ko:K03727	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DSHCT,Helicase_C,rRNA_proc-arch
HKD1_k127_5547180_14	398767.Glov_0371	2.903e-15	83.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,42SG5@68525|delta/epsilon subdivisions,2WNPI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ada_Zn_binding,Excalibur,SNase
HKD1_k127_5547180_7	671143.DAMO_1576	5.834e-139	455.0	COG1322@1|root,COG1322@2|Bacteria,2NPXU@2323|unclassified Bacteria	2|Bacteria	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD1_k127_5549262_1	1123508.JH636444_gene5599	7.241e-59	212.0	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_5549262_0	1299327.I546_5948	1.673e-81	291.0	28NDD@1|root,2ZBG6@2|Bacteria,2H1UZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5549262_2	886293.Sinac_3833	1.8e-15	76.0	COG2897@1|root,COG2897@2|Bacteria,2J06E@203682|Planctomycetes	203682|Planctomycetes	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_5563241_6	861299.J421_2438	5.172e-29	124.0	COG1309@1|root,COG1309@2|Bacteria,1ZTT6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Bacterial transcriptional repressor C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HKD1_k127_5563241_5	671143.DAMO_2133	1.885e-61	228.0	COG0845@1|root,COG0845@2|Bacteria,2NPNY@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	ybhG	GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0016020,GO:0042221,GO:0044464,GO:0046677,GO:0050896,GO:0071944	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_5563241_2	269799.Gmet_0658	3.07e-100	337.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42PIB@68525|delta/epsilon subdivisions,2WKFC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	ybhF-N	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_5563241_3	1123392.AQWL01000002_gene1826	1.24e-99	334.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2VHRB@28216|Betaproteobacteria,1KTII@119069|Hydrogenophilales	119069|Hydrogenophilales	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5563241_4	247490.KSU1_D0847	9.635e-95	336.0	COG0842@1|root,COG0842@2|Bacteria,2J1QC@203682|Planctomycetes	203682|Planctomycetes	V	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
HKD1_k127_5563241_1	269799.Gmet_3460	1.962e-103	355.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,42NC3@68525|delta/epsilon subdivisions,2WIJJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_5563241_0	316274.Haur_2806	6.911e-105	362.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi,37674@32061|Chloroflexia	32061|Chloroflexia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_5564343_0	926549.KI421517_gene3415	2.499e-122	413.0	COG0668@1|root,COG0668@2|Bacteria,4NHU7@976|Bacteroidetes,47JMR@768503|Cytophagia	976|Bacteroidetes	M	Mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
HKD1_k127_5564343_2	909663.KI867150_gene893	3.214e-65	231.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_5564343_3	1267533.KB906737_gene1584	3.609e-62	237.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
HKD1_k127_5564343_1	269799.Gmet_1397	3.157e-76	263.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,43UCF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_5566108_0	452637.Oter_3218	2.73e-263	818.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C,RicinB_lectin_2
HKD1_k127_55665_2	1297570.MESS4_510020	1.63e-136	438.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,43H4C@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_55665_4	1382359.JIAL01000001_gene2053	3.356e-56	198.0	COG1942@1|root,COG4334@1|root,COG1942@2|Bacteria,COG4334@2|Bacteria,3Y8F4@57723|Acidobacteria,2JNSH@204432|Acidobacteriia	204432|Acidobacteriia	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_55665_1	1179778.PMM47T1_21893	9.813e-173	546.0	COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,1RRPT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	-	ko:K18369	ko00640,map00640	-	R10703	RC00545	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_55665_3	671143.DAMO_2292	1.741e-127	418.0	COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria	2|Bacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_55665_0	243231.GSU3064	1.951e-176	564.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD1_k127_55665_5	671143.DAMO_2294	3.426e-44	173.0	COG1589@1|root,COG1589@2|Bacteria,2NQ2T@2323|unclassified Bacteria	2|Bacteria	D	Essential cell division protein	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0040007,GO:0042802,GO:0043093,GO:0044085,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	6.3.2.4	ko:K01921,ko:K03589,ko:K06438	ko00473,ko00550,ko01100,ko01502,ko04112,map00473,map00550,map01100,map01502,map04112	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	FtsQ,POTRA_1
HKD1_k127_55665_6	671143.DAMO_2295	8.289e-31	123.0	COG0812@1|root,COG0812@2|Bacteria,2NPHQ@2323|unclassified Bacteria	2|Bacteria	M	Cell wall formation	murB	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008360,GO:0008762,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016043,GO:0016491,GO:0016614,GO:0016616,GO:0022603,GO:0022604,GO:0030203,GO:0034645,GO:0036094,GO:0042546,GO:0043167,GO:0043168,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045229,GO:0048037,GO:0050660,GO:0050662,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0055114,GO:0065007,GO:0065008,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.3.1.98,6.3.2.4	ko:K00075,ko:K01921	ko00473,ko00520,ko00550,ko01100,ko01502,map00473,map00520,map00550,map01100,map01502	-	R01150,R03191,R03192	RC00064,RC00141,RC02639	ko00000,ko00001,ko01000,ko01011	-	-	iECED1_1282.ECED1_4683,iECUMN_1333.ECUMN_4498_AT6,iIT341.HP1418,iLF82_1304.LF82_1416,iNRG857_1313.NRG857_19845,iYO844.BSU15230	FAD_binding_4,MurB_C
HKD1_k127_5567682_0	886293.Sinac_3341	9.508e-155	501.0	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_5575894_4	671143.DAMO_0681	1.08e-66	241.0	COG0739@1|root,COG0739@2|Bacteria,2NPG3@2323|unclassified Bacteria	2|Bacteria	M	Peptidase family M23	yebA2	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD1_k127_5575894_0	671143.DAMO_0682	0.0	1273.0	COG0653@1|root,COG0653@2|Bacteria,2NNRK@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	GO:0000166,GO:0002790,GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005887,GO:0006457,GO:0006605,GO:0006810,GO:0006886,GO:0008104,GO:0008144,GO:0008150,GO:0008320,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015399,GO:0015405,GO:0015440,GO:0015450,GO:0015462,GO:0015627,GO:0015628,GO:0015833,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0031522,GO:0032553,GO:0032555,GO:0032559,GO:0032940,GO:0032991,GO:0033036,GO:0033220,GO:0034613,GO:0035639,GO:0036094,GO:0042623,GO:0042626,GO:0042802,GO:0042886,GO:0042887,GO:0043167,GO:0043168,GO:0043492,GO:0043952,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0061077,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0097159,GO:0097367,GO:0098776,GO:1901265,GO:1901363,GO:1904680	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_5575894_1	671143.DAMO_0686	2.943e-109	359.0	COG0388@1|root,COG0388@2|Bacteria,2NPKU@2323|unclassified Bacteria	2|Bacteria	S	Carbon-nitrogen hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HKD1_k127_5575894_6	1219084.AP014508_gene186	2.858e-59	218.0	COG3836@1|root,COG3836@2|Bacteria	2|Bacteria	G	2-keto-3-deoxy-L-rhamnonate aldolase activity	-	-	4.1.2.20,4.1.2.52	ko:K01630,ko:K02510	ko00053,ko00350,ko01120,map00053,map00350,map01120	-	R01645,R01647,R02754,R03277	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_5575894_5	1280001.BAOA01000007_gene3935	5.545e-65	234.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,1RPNJ@1236|Gammaproteobacteria,1XU8W@135623|Vibrionales	135623|Vibrionales	G	TRAP-type C4-dicarboxylate transport system, periplasmic component	-	-	-	ko:K11688	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_5575894_8	1168059.KB899087_gene3180	2.18e-16	88.0	COG3090@1|root,COG3090@2|Bacteria,1R7TV@1224|Proteobacteria,2U344@28211|Alphaproteobacteria,3F079@335928|Xanthobacteraceae	28211|Alphaproteobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_5575894_2	1069080.KB913028_gene207	1.854e-98	337.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,4H2ID@909932|Negativicutes	909932|Negativicutes	G	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5575894_3	1131730.BAVI_16857	1.624e-86	303.0	COG2159@1|root,COG2159@2|Bacteria,1UZI6@1239|Firmicutes	1239|Firmicutes	G	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_5575894_7	398767.Glov_2264	1.652e-45	167.0	COG0011@1|root,COG0011@2|Bacteria,1N1NM@1224|Proteobacteria,42SC4@68525|delta/epsilon subdivisions,2WPHK@28221|Deltaproteobacteria,43VXI@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Thiamine-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
HKD1_k127_56091_1	1123274.KB899420_gene4032	4.425e-83	287.0	COG0673@1|root,COG0673@2|Bacteria	2|Bacteria	S	inositol 2-dehydrogenase activity	-	-	1.1.1.18,1.1.1.369	ko:K00010,ko:K03810	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_56091_4	1380394.JADL01000001_gene2662	5.088e-64	227.0	2A4JH@1|root,30T65@2|Bacteria,1R6JU@1224|Proteobacteria,2U01E@28211|Alphaproteobacteria,2JWPJ@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_56091_5	1132441.KI519455_gene3877	5.561e-55	206.0	COG0673@1|root,COG0673@2|Bacteria,2GM7J@201174|Actinobacteria	201174|Actinobacteria	K	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_56091_3	1449065.JMLL01000012_gene3716	3.885e-64	238.0	COG1653@1|root,COG1653@2|Bacteria,1MV8A@1224|Proteobacteria,2TTPV@28211|Alphaproteobacteria,43M3D@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_1
HKD1_k127_56091_2	1449065.JMLL01000012_gene3713	5.195e-71	252.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TQZY@28211|Alphaproteobacteria,43KJ7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	COG1175 ABC-type sugar transport systems permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_56091_6	1410620.SHLA_36c000070	2.37e-51	201.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2TU85@28211|Alphaproteobacteria,4B8P2@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K10229	ko02010,map02010	M00200,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.5	-	-	BPD_transp_1
HKD1_k127_56091_0	996637.SGM_6286	3.294e-93	319.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria	201174|Actinobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_56091_7	1499967.BAYZ01000089_gene5042	2.267e-39	152.0	COG2030@1|root,COG2030@2|Bacteria,2NRNG@2323|unclassified Bacteria	2|Bacteria	I	N-terminal half of MaoC dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_56091_9	338966.Ppro_1041	2.133e-19	94.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,42WFT@68525|delta/epsilon subdivisions,2WRC3@28221|Deltaproteobacteria,43V9P@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_56091_8	158500.BV97_03783	6.742e-26	115.0	COG1802@1|root,COG1802@2|Bacteria,1RBIC@1224|Proteobacteria,2TSVQ@28211|Alphaproteobacteria,2K3AR@204457|Sphingomonadales	204457|Sphingomonadales	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_56091_10	1298860.AUEM01000006_gene2574	5.826e-06	57.0	COG2376@1|root,COG2376@2|Bacteria,2GJV9@201174|Actinobacteria,4FKWS@85023|Microbacteriaceae	201174|Actinobacteria	G	Dak1 domain	dhaK2	-	2.7.1.121,2.7.1.28,2.7.1.29,4.6.1.15	ko:K00863,ko:K05878	ko00051,ko00561,ko00680,ko01100,ko01120,ko01200,ko04622,map00051,map00561,map00680,map01100,map01120,map01200,map04622	M00344	R01011,R01012,R01059	RC00002,RC00015,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Dak1,Dak2
HKD1_k127_5609397_0	935840.JAEQ01000016_gene2209	2.937e-161	523.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TS14@28211|Alphaproteobacteria,43MT1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD1_k127_5609397_19	675635.Psed_2112	1.149e-47	180.0	COG0662@1|root,COG0662@2|Bacteria,2H87D@201174|Actinobacteria,4EDBR@85010|Pseudonocardiales	201174|Actinobacteria	G	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5609397_13	309801.trd_0072	2.566e-81	284.0	COG0524@1|root,COG0524@2|Bacteria,2G7YB@200795|Chloroflexi,27YGK@189775|Thermomicrobia	189775|Thermomicrobia	G	pfkB family carbohydrate kinase	-	-	2.7.1.4	ko:K00847	ko00051,ko00500,ko00520,ko01100,map00051,map00500,map00520,map01100	-	R00760,R00867,R03920	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_5609397_20	1333523.L593_14285	2.847e-37	145.0	COG1063@1|root,arCOG01459@2157|Archaea,2XUPT@28890|Euryarchaeota,23SUB@183963|Halobacteria	183963|Halobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5609397_24	384765.SIAM614_05291	4.834e-22	105.0	COG1802@1|root,COG1802@2|Bacteria,1MVXM@1224|Proteobacteria,2TT9E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional regulator GntR family	mcbR	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_5609397_2	1218074.BAXZ01000016_gene3330	5.342e-138	449.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,1K0E9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_5609397_14	33876.JNXY01000007_gene8187	4.431e-64	233.0	COG1063@1|root,COG1063@2|Bacteria,2GKC7@201174|Actinobacteria,4DANT@85008|Micromonosporales	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5609397_4	1218074.BAXZ01000016_gene3330	3.281e-133	438.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2VHFW@28216|Betaproteobacteria,1K0E9@119060|Burkholderiaceae	28216|Betaproteobacteria	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_5609397_10	371042.NG99_14605	4.263e-89	302.0	COG1788@1|root,COG1788@2|Bacteria,1NGS5@1224|Proteobacteria,1RQB6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.12	ko:K01039	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_5609397_8	371042.NG99_14600	3.993e-93	312.0	COG2057@1|root,COG2057@2|Bacteria,1MY3S@1224|Proteobacteria,1RP1U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit	catJ	-	2.8.3.12	ko:K01040	ko00643,ko00650,ko01120,map00643,map00650,map01120	-	R04000,R05509	RC00012,RC00131,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_5609397_22	1079460.ATTQ01000031_gene3987	3.45e-34	149.0	COG1653@1|root,COG1653@2|Bacteria,1N1NW@1224|Proteobacteria,2U094@28211|Alphaproteobacteria,4BAZ0@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_5609397_21	1056512.D515_00316	1.074e-36	155.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,1RP01@1236|Gammaproteobacteria,1Y24V@135623|Vibrionales	135623|Vibrionales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_5609397_16	1238450.VIBNISOn1_1120011	1.762e-54	202.0	COG1175@1|root,COG1175@2|Bacteria,1MVAZ@1224|Proteobacteria,1RRHV@1236|Gammaproteobacteria,1XTVP@135623|Vibrionales	135623|Vibrionales	P	COG1175 ABC-type sugar transport systems, permease components	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5609397_15	1122919.KB905571_gene3064	1.745e-62	229.0	COG0395@1|root,COG0395@2|Bacteria,1UZIP@1239|Firmicutes,4HHYA@91061|Bacilli,26XRN@186822|Paenibacillaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_5609397_9	397948.Cmaq_0837	1.79e-92	331.0	COG0399@1|root,arCOG00118@2157|Archaea,2XQAK@28889|Crenarchaeota	2157|Archaea	E	Belongs to the DegT DnrJ EryC1 family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_5609397_18	1121085.AUCI01000045_gene71	1.126e-50	193.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_5609397_11	1121472.AQWN01000008_gene1975	9.162e-89	297.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,260AM@186807|Peptococcaceae	186801|Clostridia	F	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_5609397_12	314256.OG2516_05473	3.604e-87	295.0	COG1028@1|root,COG1028@2|Bacteria,1MXQR@1224|Proteobacteria,2TW65@28211|Alphaproteobacteria,2PFWP@252301|Oceanicola	28211|Alphaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	MA20_09905	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_5609397_23	1122223.KB890699_gene674	1.02e-25	116.0	COG1802@1|root,COG1802@2|Bacteria,1WMP7@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_5609397_5	580327.Tthe_0641	7.469e-130	424.0	COG0673@1|root,COG0673@2|Bacteria,1TQ72@1239|Firmicutes,24XW6@186801|Clostridia,42FPN@68295|Thermoanaerobacterales	186801|Clostridia	S	Oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5609397_3	1041522.MCOL_V202375	2.901e-136	440.0	COG1735@1|root,COG1735@2|Bacteria,2GMZ6@201174|Actinobacteria,2360H@1762|Mycobacteriaceae	201174|Actinobacteria	S	Phosphotriesterase	php	-	-	ko:K07048	-	-	-	-	ko00000	-	-	-	PTE
HKD1_k127_5609397_1	1211115.ALIQ01000087_gene4477	4.988e-146	475.0	COG1653@1|root,COG1653@2|Bacteria,1R5CC@1224|Proteobacteria,2TVID@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_5609397_6	1510531.JQJJ01000009_gene1228	1.303e-107	356.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TUAN@28211|Alphaproteobacteria,3K63I@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5609397_7	1211115.ALIQ01000087_gene4475	1.252e-104	346.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2TT14@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	ABC-type sugar transport system, permease component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5609397_17	47716.JOFH01000005_gene1370	7.79e-53	206.0	COG2030@1|root,COG2030@2|Bacteria,2GXE5@201174|Actinobacteria	201174|Actinobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_5626899_0	351348.Maqu_3187	2.888e-187	599.0	COG2771@1|root,COG4584@1|root,COG2771@2|Bacteria,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,46A5W@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM Integrase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_24,rve
HKD1_k127_5626899_1	1267535.KB906767_gene3700	2.538e-79	272.0	COG1484@1|root,COG1484@2|Bacteria,3Y4QK@57723|Acidobacteria,2JNWI@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
HKD1_k127_5642836_0	671143.DAMO_1990	1.915e-100	333.0	COG1207@1|root,COG1207@2|Bacteria,2NNPC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	GO:0000270,GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0003977,GO:0005488,GO:0005975,GO:0005976,GO:0006022,GO:0006023,GO:0006024,GO:0006629,GO:0006807,GO:0008080,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009252,GO:0009273,GO:0009987,GO:0016051,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0019134,GO:0022610,GO:0030203,GO:0030260,GO:0033692,GO:0034637,GO:0034645,GO:0035635,GO:0040007,GO:0042546,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044406,GO:0044409,GO:0044419,GO:0044650,GO:0046872,GO:0051701,GO:0051704,GO:0051806,GO:0051828,GO:0070569,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1903509	2.3.1.157,2.7.7.23	ko:K04042,ko:K11528,ko:K16203	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000,ko01002	3.A.1.5.2	-	iJN678.glmU,iLJ478.TM1629	Hexapep,NTP_transf_3,NTP_transferase
HKD1_k127_5642836_1	247490.KSU1_D0662	3.455e-66	241.0	COG0391@1|root,COG1011@1|root,COG0391@2|Bacteria,COG1011@2|Bacteria,2J26W@203682|Planctomycetes	203682|Planctomycetes	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD1_k127_5642836_2	1128421.JAGA01000001_gene2424	7.463e-05	45.0	COG0667@1|root,COG0667@2|Bacteria,2NPI2@2323|unclassified Bacteria	2|Bacteria	C	Aldo/keto reductase family	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_5649199_1	497964.CfE428DRAFT_6579	8.018e-65	228.0	COG3832@1|root,COG3832@2|Bacteria,46SRI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Activator of Hsp90 ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_5649199_2	1267535.KB906767_gene5136	2.513e-61	216.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_7
HKD1_k127_5649199_0	1238182.C882_0582	2.516e-123	423.0	COG2982@1|root,COG2982@2|Bacteria,1MUAN@1224|Proteobacteria,2U26R@28211|Alphaproteobacteria,2JPQ3@204441|Rhodospirillales	204441|Rhodospirillales	M	AsmA family	-	-	-	ko:K07289,ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2
HKD1_k127_5649199_4	909663.KI867150_gene1399	2.797e-25	109.0	2CFNS@1|root,331AJ@2|Bacteria,1NBYG@1224|Proteobacteria,42VZ5@68525|delta/epsilon subdivisions,2WR8A@28221|Deltaproteobacteria,2MS7D@213462|Syntrophobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5649199_3	526227.Mesil_2197	1.493e-34	141.0	COG1970@1|root,COG1970@2|Bacteria,1WK0I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_5654407_6	945713.IALB_0818	1.775e-50	183.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD1_k127_5654407_1	1499967.BAYZ01000163_gene6599	2.024e-98	334.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_5654407_9	1205680.CAKO01000038_gene1609	0.0006171	45.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,2JRAR@204441|Rhodospirillales	204441|Rhodospirillales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_5654407_4	443598.AUFA01000017_gene7349	4.06e-78	274.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TZRR@28211|Alphaproteobacteria,3JTDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5654407_2	595537.Varpa_5387	2.363e-85	301.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2VNEK@28216|Betaproteobacteria,4AEIK@80864|Comamonadaceae	28216|Betaproteobacteria	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5654407_7	555779.Dthio_PD0647	1.061e-49	186.0	COG0145@1|root,COG0145@2|Bacteria,1NCAX@1224|Proteobacteria,42VH8@68525|delta/epsilon subdivisions,2WRRV@28221|Deltaproteobacteria,2MFSF@213115|Desulfovibrionales	28221|Deltaproteobacteria	EQ	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
HKD1_k127_5654407_3	1499967.BAYZ01000163_gene6599	1.499e-83	291.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_5654407_5	521460.Athe_2582	5.27e-65	230.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
HKD1_k127_5654407_0	324602.Caur_3552	6.665e-111	373.0	COG2006@1|root,COG2006@2|Bacteria	2|Bacteria	U	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088,DUF362
HKD1_k127_5654407_8	604354.TSIB_1472	7.971e-06	50.0	COG1146@1|root,arCOG00959@2157|Archaea,2XZY3@28890|Euryarchaeota,244JJ@183968|Thermococci	183968|Thermococci	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	korD	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4
HKD1_k127_5687528_1	420324.KI912007_gene8886	1.618e-89	302.0	COG0697@1|root,COG0697@2|Bacteria,1PB22@1224|Proteobacteria,2U158@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	MA20_36650	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_5687528_0	1499967.BAYZ01000076_gene768	9.355e-96	324.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5687528_2	1499967.BAYZ01000076_gene767	8.562e-20	90.0	COG1175@1|root,COG1175@2|Bacteria,2NPAH@2323|unclassified Bacteria	2|Bacteria	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
HKD1_k127_5707045_4	335543.Sfum_3146	6.426e-22	97.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5707045_2	1122222.AXWR01000009_gene686	4.01e-54	203.0	COG1028@1|root,COG1028@2|Bacteria,1WJ1T@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_5707045_1	1125725.HMPREF1325_0007	1.531e-57	214.0	COG1638@1|root,COG1638@2|Bacteria,2J5GS@203691|Spirochaetes	203691|Spirochaetes	G	PFAM Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_5707045_6	1077972.ARGLB_069_00750	5.238e-07	58.0	COG1593@1|root,COG1593@2|Bacteria,2GXEY@201174|Actinobacteria	201174|Actinobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
HKD1_k127_5707045_0	994573.T472_0200300	7.066e-88	305.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,36G8D@31979|Clostridiaceae	186801|Clostridia	G	Trap dicarboxylate transporter, dctm subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5707045_5	1356854.N007_14780	1.328e-20	93.0	COG0551@1|root,COG0551@2|Bacteria	2|Bacteria	L	DNA topological change	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
HKD1_k127_5707045_3	1210908.HSB1_33640	1.185e-53	194.0	COG1028@1|root,arCOG01259@2157|Archaea,2XVZM@28890|Euryarchaeota,23UKP@183963|Halobacteria	183963|Halobacteria	I	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_5726241_8	671143.DAMO_1078	4.08e-11	63.0	COG1327@1|root,COG1327@2|Bacteria,2NPEU@2323|unclassified Bacteria	2|Bacteria	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008144,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0017076,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_5726241_0	671143.DAMO_1077	1.137e-199	629.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081,iIT341.HP0183	SHMT
HKD1_k127_5726241_6	671143.DAMO_0450	1.067e-59	217.0	COG0741@1|root,COG0741@2|Bacteria,2NPR5@2323|unclassified Bacteria	2|Bacteria	M	Transglycosylase SLT domain	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	DUF4124,SLT
HKD1_k127_5726241_5	1096546.WYO_2484	5.722e-89	301.0	COG0410@1|root,COG0410@2|Bacteria,1Q0CV@1224|Proteobacteria,2TTSP@28211|Alphaproteobacteria,1JU8C@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_5726241_1	1510531.JQJJ01000014_gene4788	2.249e-176	570.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3JSQW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD1_k127_5726241_3	460265.Mnod_6586	9.388e-108	357.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,1JU9S@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5726241_2	709797.CSIRO_2251	2.511e-113	377.0	COG0683@1|root,COG0683@2|Bacteria,1N3V5@1224|Proteobacteria,2U1KS@28211|Alphaproteobacteria,3JVMY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_5726241_4	760568.Desku_3082	1.903e-94	325.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,261MT@186807|Peptococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	ko:K19954	-	-	-	-	ko00000,ko01000	-	-	-	Fe-ADH
HKD1_k127_5726241_7	314230.DSM3645_23526	3.591e-48	186.0	COG0834@1|root,COG0834@2|Bacteria,2J3K3@203682|Planctomycetes	203682|Planctomycetes	ET	COG0834 ABC-type amino acid transport signal transduction systems, periplasmic component domain	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_5726241_9	1122604.JONR01000007_gene2919	1.766e-08	57.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1X3EN@135614|Xanthomonadales	135614|Xanthomonadales	O	Belongs to the peptidase S1C family	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD1_k127_572885_0	1157708.KB907454_gene3048	4.638e-115	389.0	COG0683@1|root,COG0683@2|Bacteria,1N3V5@1224|Proteobacteria,2VKRP@28216|Betaproteobacteria,4AAXR@80864|Comamonadaceae	28216|Betaproteobacteria	E	Amino acid amide ABC transporter substrate-binding protein, HAAT family	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_572885_3	258533.BN977_01173	1.694e-67	240.0	COG0411@1|root,COG0411@2|Bacteria,2GMEE@201174|Actinobacteria,23515@1762|Mycobacteriaceae	201174|Actinobacteria	E	amino acid	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_572885_2	1157708.KB907454_gene3049	3.331e-95	331.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2VH2P@28216|Betaproteobacteria,4A9RF@80864|Comamonadaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_572885_1	1157708.KB907454_gene3050	1.541e-104	347.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2VIDW@28216|Betaproteobacteria,4ABK5@80864|Comamonadaceae	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_572885_4	1038860.AXAP01000042_gene96	2.931e-28	117.0	COG0111@1|root,COG0111@2|Bacteria,1NU4B@1224|Proteobacteria,2TRM8@28211|Alphaproteobacteria,3JTYB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	MA20_13185	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_5740601_9	404380.Gbem_1903	3.385e-20	94.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,43TAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_5740601_8	644966.Tmar_0933	7.407e-37	151.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,3WCMZ@538999|Clostridiales incertae sedis	186801|Clostridia	L	Conserved hypothetical protein 95	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD1_k127_5740601_7	671143.DAMO_1389	4.803e-54	196.0	COG0669@1|root,COG0669@2|Bacteria,2NPDV@2323|unclassified Bacteria	2|Bacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006082,GO:0006139,GO:0006163,GO:0006164,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0015939,GO:0015940,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046390,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
HKD1_k127_5740601_1	671143.DAMO_1388	2.471e-148	488.0	COG0436@1|root,COG0436@2|Bacteria,2NP1C@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase	aspB	GO:0003674,GO:0003824,GO:0008483,GO:0016740,GO:0016769,GO:0047297	2.6.1.1,2.6.1.14	ko:K00812,ko:K22457	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R01346,R02433,R02619,R05052	RC00006,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	iHN637.CLJU_RS06550	Aminotran_1_2
HKD1_k127_5740601_2	246194.CHY_1128	8.681e-146	497.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,42GBR@68295|Thermoanaerobacterales	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_5740601_3	118166.JH976537_gene4019	5.511e-119	393.0	COG0601@1|root,COG0601@2|Bacteria,1G01A@1117|Cyanobacteria,1HA01@1150|Oscillatoriales	1117|Cyanobacteria	P	'ABC-type dipeptide oligopeptide nickel transport	-	-	-	ko:K02033,ko:K15581,ko:K15585	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD1_k127_5740601_6	670487.Ocepr_0877	4.849e-91	310.0	COG1173@1|root,COG1173@2|Bacteria,1WIH4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	EP	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppC	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_5740601_0	247633.GP2143_05390	1.369e-150	493.0	COG4166@1|root,COG4166@2|Bacteria,1P91R@1224|Proteobacteria,1RN57@1236|Gammaproteobacteria,1J7I8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_5740601_4	1033802.SSPSH_000607	1.356e-105	351.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD1_k127_5740601_5	247633.GP2143_05380	2.425e-92	320.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1J697@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	EP	Binding-protein-dependent transport system inner membrane component	oppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAF1260.b1245,iB21_1397.B21_01229,iEC55989_1330.EC55989_1342,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECDH10B_1368.ECDH10B_1307,iECDH1ME8569_1439.ECDH1ME8569_1185,iECD_1391.ECD_01219,iECIAI1_1343.ECIAI1_1264,iECO103_1326.ECO103_1345,iECO111_1330.ECO111_1572,iECO26_1355.ECO26_1756,iECSE_1348.ECSE_1293,iECSP_1301.ECSP_1637,iECUMN_1333.ECUMN_1542,iECW_1372.ECW_m1337,iECs_1301.ECs1745,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcHS_1320.EcHS_A1354,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iJO1366.b1245,iSSON_1240.SSON_1935,iUMNK88_1353.UMNK88_1565,iWFL_1372.ECW_m1337,iY75_1357.Y75_RS06515,iZ_1308.Z2021	BPD_transp_1,OppC_N
HKD1_k127_5759769_0	204669.Acid345_4390	1.948e-85	292.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_5759769_1	1379698.RBG1_1C00001G0607	6.282e-42	163.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_5806761_2	1304875.JAFZ01000003_gene660	1.013e-10	64.0	COG1489@1|root,COG1489@2|Bacteria,3TB3T@508458|Synergistetes	508458|Synergistetes	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	DUF123,SfsA
HKD1_k127_5806761_0	329726.AM1_5447	2.751e-120	407.0	COG0464@1|root,COG0464@2|Bacteria,1G2M7@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_5806761_1	671143.DAMO_0069	1.298e-76	271.0	COG1373@1|root,COG1373@2|Bacteria,2NP9F@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4143)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_14,DUF4143
HKD1_k127_582445_0	469383.Cwoe_1256	5.065e-42	162.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CCP_MauG,UnbV_ASPIC,VCBS
HKD1_k127_582445_1	742766.HMPREF9455_00332	9.607e-12	78.0	COG0383@1|root,COG0383@2|Bacteria,4NGF5@976|Bacteroidetes,2FRK9@200643|Bacteroidia,22Z81@171551|Porphyromonadaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 38 C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_38,Glyco_hydro_38C
HKD1_k127_5842797_0	357808.RoseRS_3858	0.0	1031.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2G5ZQ@200795|Chloroflexi,376AA@32061|Chloroflexia	32061|Chloroflexia	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD1_k127_5842797_2	1340493.JNIF01000003_gene3814	1.972e-74	263.0	COG3391@1|root,COG3391@2|Bacteria,3Y99Z@57723|Acidobacteria	57723|Acidobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HKD1_k127_5842797_1	479434.Sthe_1657	1.205e-95	323.0	COG0648@1|root,COG0648@2|Bacteria,2G5XZ@200795|Chloroflexi,27XEG@189775|Thermomicrobia	189775|Thermomicrobia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_5842797_3	671143.DAMO_2525	2.27e-24	104.0	2EA3B@1|root,3348D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5849655_1	649638.Trad_0032	5.858e-27	113.0	COG2318@1|root,COG2318@2|Bacteria,1WKK4@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_5849655_0	646529.Desaci_4364	3.138e-91	313.0	COG3547@1|root,COG3547@2|Bacteria,1V427@1239|Firmicutes,24E1F@186801|Clostridia	186801|Clostridia	L	transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_5863285_2	82654.Pse7367_1525	2.527e-08	58.0	arCOG08935@1|root,32Z08@2|Bacteria,1GAUH@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5863366_1	587753.EY04_01435	1.232e-160	523.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,1RMEB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoG	GO:0000271,GO:0005575,GO:0005623,GO:0005975,GO:0005976,GO:0006073,GO:0006950,GO:0006970,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009628,GO:0009987,GO:0016051,GO:0030288,GO:0030313,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042597,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0050896,GO:0051273,GO:0051274,GO:0071704,GO:1901576	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
HKD1_k127_5863366_0	1123393.KB891332_gene2720	4.958e-304	955.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,2VHDC@28216|Betaproteobacteria,1KSQQ@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Glycosyl transferase family 21	-	-	-	ko:K03669	-	-	-	-	ko00000,ko01000,ko01003,ko02000	4.D.3.1.1	GT2	-	Glycos_transf_2
HKD1_k127_5863366_3	648885.KB316283_gene3030	1.936e-33	141.0	2DMF8@1|root,32R47@2|Bacteria,1RJ0J@1224|Proteobacteria,2UFI8@28211|Alphaproteobacteria,1JUPT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Lipocalin_5
HKD1_k127_5863366_2	526227.Mesil_3475	6.751e-34	135.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_5874954_1	1210884.HG799470_gene14318	5.491e-23	105.0	COG5659@1|root,COG5659@2|Bacteria,2IWRG@203682|Planctomycetes	203682|Planctomycetes	L	best DB hits BLAST gb AAD45539.1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_5874954_2	886293.Sinac_4025	3.527e-15	89.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2IXZY@203682|Planctomycetes	203682|Planctomycetes	T	COG0515 Serine threonine protein	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_10,TPR_11,TPR_12,TPR_8,WD40
HKD1_k127_5874954_0	1173028.ANKO01000130_gene1840	2.03e-122	415.0	COG3307@1|root,COG3307@2|Bacteria,1G33N@1117|Cyanobacteria,1H8GN@1150|Oscillatoriales	1117|Cyanobacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD1_k127_5882337_1	1121423.JONT01000007_gene534	4.7e-58	206.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,26166@186807|Peptococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
HKD1_k127_5882337_2	335543.Sfum_0199	6.188e-45	166.0	COG0838@1|root,COG0838@2|Bacteria,1PPP3@1224|Proteobacteria,42VF4@68525|delta/epsilon subdivisions,2WRIV@28221|Deltaproteobacteria,2MQKR@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_5882337_0	335543.Sfum_0200	3.364e-62	220.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,42MDJ@68525|delta/epsilon subdivisions,2WNNV@28221|Deltaproteobacteria,2MQDB@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_5918303_0	204669.Acid345_0206	8.467e-92	316.0	COG2989@1|root,COG2989@2|Bacteria,3Y2YW@57723|Acidobacteria,2JIFK@204432|Acidobacteriia	2|Bacteria	S	ErfK YbiS YcfS YnhG family protein	ycbB	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD1_k127_5918303_1	290318.Cvib_0364	6.385e-21	96.0	COG2606@1|root,COG2606@2|Bacteria,1FF1M@1090|Chlorobi	1090|Chlorobi	S	PFAM YbaK prolyl-tRNA synthetase associated region	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_5943789_6	1122947.FR7_1153	7.166e-49	178.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,4H2N6@909932|Negativicutes	1239|Firmicutes	G	Transketolase, pyridine binding domain protein	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_5943789_2	1122947.FR7_1152	1.26e-108	364.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,4H24Q@909932|Negativicutes	909932|Negativicutes	G	Transketolase, thiamine diphosphate binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Transketolase_N
HKD1_k127_5943789_5	1122919.KB905560_gene1459	1.004e-62	222.0	COG4126@1|root,COG4126@2|Bacteria,1UKAT@1239|Firmicutes,4IUSR@91061|Bacilli,277R8@186822|Paenibacillaceae	91061|Bacilli	E	Asp/Glu/Hydantoin racemase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5943789_3	666686.B1NLA3E_01390	7.633e-108	361.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,4HD08@91061|Bacilli,1ZPZV@1386|Bacillus	91061|Bacilli	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5943789_0	1037409.BJ6T_87390	1.011e-112	378.0	COG1653@1|root,COG1653@2|Bacteria,1R5NT@1224|Proteobacteria,2TTRQ@28211|Alphaproteobacteria,3JSBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_5943789_1	696369.KI912183_gene1353	4.356e-111	369.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,261ZF@186807|Peptococcaceae	186801|Clostridia	C	Zinc-binding dehydrogenase	tdh	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5943789_4	696369.KI912183_gene1352	5.892e-73	258.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,24ATV@186801|Clostridia,263FM@186807|Peptococcaceae	186801|Clostridia	E	Zinc-binding dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5943789_7	360910.BAV0650	2.247e-07	53.0	COG3395@1|root,COG3395@2|Bacteria,1MW4G@1224|Proteobacteria,2VM43@28216|Betaproteobacteria,3T5RX@506|Alcaligenaceae	28216|Betaproteobacteria	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HKD1_k127_5970513_2	452637.Oter_3678	3.217e-72	247.0	COG1908@1|root,COG1908@2|Bacteria	2|Bacteria	C	Methyl-viologen-reducing hydrogenase, delta subunit	bamF	-	1.8.98.5,1.8.98.6	ko:K14127,ko:K14128	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2083	Fer4,FlpD,HTH_5
HKD1_k127_5970513_0	452637.Oter_3679	1.045e-143	462.0	COG1941@1|root,COG1941@2|Bacteria,46T7U@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	frhG	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
HKD1_k127_5970513_1	452637.Oter_3680	3.73e-83	284.0	COG3259@1|root,COG3259@2|Bacteria,46STG@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Nickel-dependent hydrogenase	frhA	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_5970767_4	861299.J421_2552	1.057e-30	125.0	COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_5970767_0	706587.Desti_3024	3.497e-104	348.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,43DPM@68525|delta/epsilon subdivisions,2X9UC@28221|Deltaproteobacteria,2MS8D@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5970767_1	443143.GM18_0083	2.099e-84	294.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNUR@28221|Deltaproteobacteria,43TZW@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_5970767_3	1121272.KB903283_gene5123	1.902e-51	188.0	COG1917@1|root,COG1917@2|Bacteria,2IIQY@201174|Actinobacteria	201174|Actinobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,SnoaL_2
HKD1_k127_5970767_5	443218.AS9A_1450	0.0007204	44.0	COG4274@1|root,COG4274@2|Bacteria,2IJ0R@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_5970767_2	331869.BAL199_29922	1.981e-61	217.0	COG5553@1|root,COG5553@2|Bacteria,1RD6A@1224|Proteobacteria,2U7HF@28211|Alphaproteobacteria,4BT3J@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent enzyme of the double-stranded beta helix superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_598195_0	1120983.KB894570_gene1548	5.349e-289	898.0	COG1982@1|root,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2TSSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	COG1982 Arginine lysine ornithine decarboxylases	-	-	4.1.1.19	ko:K01584	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HKD1_k127_598195_1	224911.27351735	5.094e-102	336.0	COG2985@1|root,COG2985@2|Bacteria,1MUVM@1224|Proteobacteria,2U1RU@28211|Alphaproteobacteria,3JU9U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	potassium ion transport	-	-	-	ko:K07085	-	-	-	-	ko00000	2.A.81	-	-	Asp-Al_Ex,TrkA_C
HKD1_k127_5982441_3	278957.ABEA03000193_gene1037	1.142e-05	51.0	COG0042@1|root,COG0042@2|Bacteria,46TCT@74201|Verrucomicrobia,3K895@414999|Opitutae	414999|Opitutae	H	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD1_k127_5982441_1	497964.CfE428DRAFT_5950	3.136e-137	444.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	emrY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K03446,ko:K07786	ko02020,map02020	M00701	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.3,2.A.1.3.36	-	-	MFS_1
HKD1_k127_5982441_0	204669.Acid345_1748	1.381e-196	628.0	COG0492@1|root,COG0492@2|Bacteria,3Y3SH@57723|Acidobacteria,2JI51@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_5982441_2	452637.Oter_3878	3.294e-08	55.0	COG1057@1|root,COG1057@2|Bacteria,46S7M@74201|Verrucomicrobia,3K7ME@414999|Opitutae	414999|Opitutae	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6009127_0	671143.DAMO_2534	1.802e-274	872.0	COG1197@1|root,COG1197@2|Bacteria,2NNMM@2323|unclassified Bacteria	2|Bacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_6009127_8	671143.DAMO_2535	6.209e-49	181.0	COG0615@1|root,COG0615@2|Bacteria,2NPMA@2323|unclassified Bacteria	2|Bacteria	IM	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	aut	-	2.7.1.167,2.7.7.70	ko:K03272,ko:K21345	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like
HKD1_k127_6009127_3	330214.NIDE4314	1.382e-108	361.0	COG1899@1|root,COG1899@2|Bacteria	2|Bacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6009127_7	671143.DAMO_1147	2.623e-57	205.0	COG0315@1|root,COG0315@2|Bacteria,2NPNE@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	GO:0002682,GO:0002683,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005576,GO:0006732,GO:0006777,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009605,GO:0009607,GO:0009987,GO:0016043,GO:0016829,GO:0016849,GO:0018130,GO:0019538,GO:0019637,GO:0019720,GO:0022607,GO:0031347,GO:0031348,GO:0034214,GO:0035821,GO:0040007,GO:0042802,GO:0043170,GO:0043207,GO:0043545,GO:0043933,GO:0044003,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044413,GO:0044414,GO:0044419,GO:0045088,GO:0045824,GO:0046483,GO:0048519,GO:0048583,GO:0048585,GO:0050776,GO:0050777,GO:0050789,GO:0050896,GO:0051186,GO:0051188,GO:0051189,GO:0051259,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0051832,GO:0051833,GO:0052031,GO:0052037,GO:0052167,GO:0052170,GO:0052173,GO:0052200,GO:0052255,GO:0052261,GO:0052306,GO:0052309,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0061799,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0075136,GO:0080134,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD1_k127_6009127_9	671143.DAMO_1149	3.192e-36	139.0	COG1278@1|root,COG1278@2|Bacteria,2NPTN@2323|unclassified Bacteria	2|Bacteria	K	Probable zinc-ribbon domain	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD,Ribosomal_S30AE,zf-trcl
HKD1_k127_6009127_2	671143.DAMO_1155	1.896e-146	479.0	COG1921@1|root,COG1921@2|Bacteria,2NNT6@2323|unclassified Bacteria	2|Bacteria	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006	Se-cys_synth_N,SelA
HKD1_k127_6009127_11	404589.Anae109_1482	1.423e-22	112.0	2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,2YV84@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6009127_5	671143.DAMO_1156	3.759e-62	220.0	COG0125@1|root,COG0125@2|Bacteria,2NPFT@2323|unclassified Bacteria	2|Bacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_6009127_6	671143.DAMO_1157	3.573e-58	214.0	COG2812@1|root,COG2812@2|Bacteria,2NPH0@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD1_k127_6009127_4	264732.Moth_0044	5.497e-64	237.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,42ETV@68295|Thermoanaerobacterales	186801|Clostridia	S	PSP1 domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
HKD1_k127_6009127_1	671143.DAMO_1159	5.406e-210	666.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,2NNTX@2323|unclassified Bacteria	2|Bacteria	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	GO:0003674,GO:0003824,GO:0004812,GO:0004825,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006431,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0040007,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.10,6.1.1.20	ko:K01874,ko:K01890	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R03660,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD1_k127_6015768_33	909663.KI867150_gene893	7.629e-62	222.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_6015768_43	240015.ACP_3398	3.551e-09	61.0	2E34G@1|root,32Y4J@2|Bacteria,3Y5JB@57723|Acidobacteria,2JJW7@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6015768_41	748247.AZKH_0188	8.224e-19	93.0	COG3064@1|root,COG3064@2|Bacteria,1R7D3@1224|Proteobacteria,2VPWE@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6015768_20	204669.Acid345_3274	6.025e-141	462.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6015768_12	555779.Dthio_PD2814	1.113e-173	552.0	COG1830@1|root,COG1830@2|Bacteria,1MW9N@1224|Proteobacteria,42PEB@68525|delta/epsilon subdivisions,2WM0Y@28221|Deltaproteobacteria,2M98D@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	fbaB	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD1_k127_6015768_47	1123024.AUII01000008_gene1834	0.0001884	47.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,2GJGR@201174|Actinobacteria,4DXGV@85010|Pseudonocardiales	201174|Actinobacteria	S	DNA internalization-related competence protein ComEC Rec2	comEC	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD1_k127_6015768_7	1094980.Mpsy_0120	1.795e-209	657.0	COG2873@1|root,arCOG00061@2157|Archaea,2XSWM@28890|Euryarchaeota,2N9AN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_6015768_18	665571.STHERM_c07830	1.025e-146	485.0	COG2021@1|root,COG2021@2|Bacteria,2JA6P@203691|Spirochaetes	203691|Spirochaetes	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metXA	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_6015768_37	926550.CLDAP_17160	2.489e-42	162.0	COG0500@1|root,COG2226@2|Bacteria,2G8YC@200795|Chloroflexi	200795|Chloroflexi	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
HKD1_k127_6015768_8	203119.Cthe_2793	2.114e-183	580.0	COG0436@1|root,COG0436@2|Bacteria,1TQP0@1239|Firmicutes,2488K@186801|Clostridia,3WI7Q@541000|Ruminococcaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6015768_35	1009370.ALO_07418	5.502e-54	204.0	COG1832@1|root,COG1832@2|Bacteria,1V7C7@1239|Firmicutes,4H4R5@909932|Negativicutes	909932|Negativicutes	S	domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_6015768_4	518766.Rmar_2339	2.007e-226	706.0	COG2873@1|root,COG2873@2|Bacteria,4NE27@976|Bacteroidetes,1FJ01@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	PFAM Cys Met metabolism pyridoxal-phosphate- dependent protein	metZ	-	2.5.1.49	ko:K01740,ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01287,R01288,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_6015768_13	926569.ANT_03920	5.992e-161	515.0	COG0031@1|root,COG0031@2|Bacteria,2G5PG@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6015768_29	926569.ANT_03930	7.653e-96	318.0	COG1045@1|root,COG1045@2|Bacteria,2G6DI@200795|Chloroflexi	200795|Chloroflexi	E	TIGRFAM serine O-acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_6015768_23	671143.DAMO_2957	7.153e-124	411.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	GO:0000096,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005739,GO:0005759,GO:0005829,GO:0006082,GO:0006139,GO:0006163,GO:0006464,GO:0006520,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016043,GO:0016226,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0018282,GO:0018283,GO:0019538,GO:0019637,GO:0019693,GO:0019752,GO:0022607,GO:0031071,GO:0031163,GO:0031974,GO:0031981,GO:0032324,GO:0034641,GO:0036211,GO:0040007,GO:0042278,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043436,GO:0043545,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044422,GO:0044424,GO:0044428,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0046983,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0065003,GO:0070013,GO:0071704,GO:0071840,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5,TusA
HKD1_k127_6015768_26	888060.HMPREF9081_1568	4.923e-105	359.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,4H2P5@909932|Negativicutes	909932|Negativicutes	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_6015768_22	1089553.Tph_c03590	6.732e-138	456.0	arCOG03330@1|root,2Z82Q@2|Bacteria,1U584@1239|Firmicutes,24B07@186801|Clostridia,42FIS@68295|Thermoanaerobacterales	186801|Clostridia	H	Methanol-cobalamin methyltransferase B subunit	-	-	2.1.1.90	ko:K04480	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00356	R04384,R09098	RC00035,RC01144,RC01145,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	MtaB
HKD1_k127_6015768_39	459349.CLOAM1439	1.49e-38	156.0	COG3170@1|root,COG3170@2|Bacteria,2NPQF@2323|unclassified Bacteria	2|Bacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_6015768_40	395494.Galf_0203	8.297e-37	148.0	2ETRW@1|root,33M9C@2|Bacteria,1NEBE@1224|Proteobacteria,2VXIY@28216|Betaproteobacteria,44W11@713636|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6015768_19	395494.Galf_0202	2.907e-142	463.0	COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,1Q1EG@1224|Proteobacteria,2VMXN@28216|Betaproteobacteria,44VCC@713636|Nitrosomonadales	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD1_k127_6015768_5	580332.Slit_0317	2.327e-219	720.0	COG1807@1|root,COG1807@2|Bacteria,1R7N1@1224|Proteobacteria,2VPJR@28216|Betaproteobacteria,44V9W@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT
HKD1_k127_6015768_38	1485544.JQKP01000011_gene764	1.232e-41	178.0	COG2246@1|root,COG2246@2|Bacteria,1N92F@1224|Proteobacteria,2VWIE@28216|Betaproteobacteria,44VSF@713636|Nitrosomonadales	28216|Betaproteobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD1_k127_6015768_11	395494.Galf_0199	1.627e-174	556.0	COG0859@1|root,COG0859@2|Bacteria,1PRP7@1224|Proteobacteria,2VMYH@28216|Betaproteobacteria,44VET@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_6015768_6	243233.MCA0472	1.357e-213	689.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales	135618|Methylococcales	F	PFAM Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_6015768_10	1034943.BN1094_00311	4.27e-175	567.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1JDPJ@118969|Legionellales	118969|Legionellales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_6015768_31	1121943.KB899999_gene1321	2.956e-81	285.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,1S22P@1236|Gammaproteobacteria,1XIZS@135619|Oceanospirillales	135619|Oceanospirillales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_6015768_0	448385.sce1628	0.0	1178.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2YXGU@29|Myxococcales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_6015768_34	215803.DB30_8102	6.668e-57	215.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,42M4G@68525|delta/epsilon subdivisions,2WKAK@28221|Deltaproteobacteria,2YUR4@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_6015768_44	867845.KI911784_gene2510	9.83e-07	56.0	2A4K7@1|root,30T6V@2|Bacteria,2GB43@200795|Chloroflexi,377VP@32061|Chloroflexia	32061|Chloroflexia	S	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.	-	-	-	-	-	-	-	-	-	-	-	-	Frankia_peptide
HKD1_k127_6015768_24	1300345.LF41_901	7.815e-119	409.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,1XDED@135614|Xanthomonadales	135614|Xanthomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_6015768_21	1329516.JPST01000012_gene181	4.209e-140	457.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,4HAVY@91061|Bacilli,27BE0@186824|Thermoactinomycetaceae	91061|Bacilli	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_6015768_2	671143.DAMO_1167	8.67e-267	872.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD1_k127_6015768_3	1121468.AUBR01000045_gene1800	2.412e-264	828.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,42FI5@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD1_k127_6015768_36	292459.STH1751	1.63e-42	167.0	COG0697@1|root,COG0697@2|Bacteria,1V3QH@1239|Firmicutes,24I9P@186801|Clostridia	186801|Clostridia	EG	Permeases of the drug metabolite transporter (DMT)	-	-	-	ko:K03298	-	-	-	-	ko00000,ko02000	2.A.7.3	-	-	EamA
HKD1_k127_6015768_30	1499967.BAYZ01000182_gene4437	1.508e-81	288.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6015768_32	1499967.BAYZ01000182_gene4438	7.258e-76	263.0	COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6015768_27	1499967.BAYZ01000182_gene4439	2.144e-104	347.0	COG4177@1|root,COG4177@2|Bacteria	2|Bacteria	E	L-phenylalanine transmembrane transporter activity	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6015768_25	1499967.BAYZ01000182_gene4440	2.767e-106	353.0	COG0559@1|root,COG0559@2|Bacteria,2NP7Z@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6015768_16	1499967.BAYZ01000182_gene4441	4.298e-155	502.0	COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria	2|Bacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6015768_14	335543.Sfum_2378	3.261e-159	518.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,42MST@68525|delta/epsilon subdivisions,2WKAN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_6015768_45	871968.DESME_08525	1.428e-06	55.0	COG2040@1|root,COG2040@2|Bacteria,1U42G@1239|Firmicutes,24CK6@186801|Clostridia,264V0@186807|Peptococcaceae	186801|Clostridia	H	Homocysteine S-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	S-methyl_trans
HKD1_k127_6015768_9	945713.IALB_0420	9.145e-182	580.0	COG1271@1|root,COG1271@2|Bacteria	2|Bacteria	C	aerobic electron transport chain	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD1_k127_6015768_17	945713.IALB_0421	1.575e-154	494.0	COG1294@1|root,COG1294@2|Bacteria	2|Bacteria	C	oxidative phosphorylation	cydB	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016679,GO:0016682,GO:0019646,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0046906,GO:0048037,GO:0055114,GO:0070069,GO:0071944,GO:0097159,GO:1901363	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iECABU_c1320.ECABU_c10120,iLF82_1304.LF82_0101,iNRG857_1313.NRG857_04455,iPC815.YPO1118,ic_1306.c1120	Cyt_bd_oxida_II
HKD1_k127_6015768_28	941824.TCEL_01675	2.796e-99	332.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,36DMA@31979|Clostridiaceae	186801|Clostridia	E	Glutamate formiminotransferase	ftcD	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
HKD1_k127_6015768_15	398578.Daci_3020	2.885e-156	499.0	COG0604@1|root,COG0604@2|Bacteria,1MU4N@1224|Proteobacteria,2VIU4@28216|Betaproteobacteria,4AD9W@80864|Comamonadaceae	28216|Betaproteobacteria	C	Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_6015768_1	1459636.NTE_01631	0.0	1079.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18594	ko00720,ko01120,map00720,map01120	-	R03157	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD1_k127_6027976_1	706587.Desti_4248	5.638e-161	511.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6027976_0	1499967.BAYZ01000169_gene6692	1.265e-167	534.0	COG0156@1|root,COG0156@2|Bacteria,2NNQ7@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0016874,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iECW_1372.ECW_m3896,iEKO11_1354.EKO11_0103,iPC815.YPO0059,iWFL_1372.ECW_m3896	Aminotran_1_2
HKD1_k127_6027976_2	1121405.dsmv_2561	1.313e-74	260.0	COG0834@1|root,COG0834@2|Bacteria,1MWDK@1224|Proteobacteria,42NVT@68525|delta/epsilon subdivisions,2WIRY@28221|Deltaproteobacteria,2MI8X@213118|Desulfobacterales	28221|Deltaproteobacteria	ET	SMART ABC-type transporter, periplasmic subunit family 3, ionotropic glutamate receptor	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_6027976_3	398767.Glov_2384	3.15e-11	68.0	2ATWF@1|root,31JFP@2|Bacteria,1RK55@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_603682_1	1009370.ALO_19662	2.163e-06	59.0	29XJR@1|root,30JAT@2|Bacteria,1VYE2@1239|Firmicutes,4H7ZX@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_603682_0	289376.THEYE_A0348	7.054e-44	167.0	COG2095@1|root,COG2095@2|Bacteria,3J0UZ@40117|Nitrospirae	40117|Nitrospirae	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD1_k127_6042143_8	411902.CLOBOL_01808	5.376e-126	414.0	COG1063@1|root,COG1063@2|Bacteria,1UI0K@1239|Firmicutes,24ATX@186801|Clostridia,220EH@1506553|Lachnoclostridium	186801|Clostridia	E	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6042143_10	344747.PM8797T_26465	1.985e-117	392.0	COG2706@1|root,COG2706@2|Bacteria,2IY02@203682|Planctomycetes	203682|Planctomycetes	G	COG2706 3-carboxymuconate cyclase	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Lactonase
HKD1_k127_6042143_27	642492.Clole_2930	6.219e-17	91.0	COG1416@1|root,COG1416@2|Bacteria,1UJJV@1239|Firmicutes	1239|Firmicutes	S	DsrE/DsrF-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE
HKD1_k127_6042143_13	479434.Sthe_0838	3.006e-108	359.0	COG0709@1|root,COG0709@2|Bacteria,2G5W4@200795|Chloroflexi,27XGA@189775|Thermomicrobia	189775|Thermomicrobia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD1_k127_6042143_26	517418.Ctha_2056	3.534e-17	91.0	COG0265@1|root,COG0265@2|Bacteria,1FDIE@1090|Chlorobi	1090|Chlorobi	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_6042143_21	448385.sce8783	1.514e-34	142.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,42UUC@68525|delta/epsilon subdivisions,2WQFQ@28221|Deltaproteobacteria,2YX9U@29|Myxococcales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD1_k127_6042143_20	1089553.Tph_c23990	1.617e-37	150.0	COG0684@1|root,COG0684@2|Bacteria,1V1ME@1239|Firmicutes,25CH0@186801|Clostridia	186801|Clostridia	H	Pfam:Methyltransf_6	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HKD1_k127_6042143_22	671143.DAMO_0014	3.846e-29	121.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
HKD1_k127_6042143_12	452637.Oter_1421	1.804e-114	378.0	COG1063@1|root,COG1063@2|Bacteria,46TQ3@74201|Verrucomicrobia,3K8T1@414999|Opitutae	414999|Opitutae	C	Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6042143_0	1499967.BAYZ01000019_gene6339	4.117e-169	554.0	COG2414@1|root,COG2414@2|Bacteria,2NP2Q@2323|unclassified Bacteria	2|Bacteria	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_6042143_25	316067.Geob_2391	5.767e-24	113.0	COG1102@1|root,COG2823@1|root,COG1102@2|Bacteria,COG2823@2|Bacteria,1N42J@1224|Proteobacteria,42TW4@68525|delta/epsilon subdivisions,2WQ5J@28221|Deltaproteobacteria,43SXA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON,Cytidylate_kin2
HKD1_k127_6042143_18	309801.trd_A0834	4.715e-69	251.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,2G84K@200795|Chloroflexi,27XSV@189775|Thermomicrobia	189775|Thermomicrobia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_6042143_4	926550.CLDAP_18370	2.823e-137	442.0	COG2897@1|root,COG2897@2|Bacteria,2G5XI@200795|Chloroflexi	200795|Chloroflexi	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_6042143_9	314278.NB231_06980	1.873e-119	388.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,1RPQV@1236|Gammaproteobacteria,1WVZT@135613|Chromatiales	135613|Chromatiales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_6042143_3	867903.ThesuDRAFT_02315	1.015e-141	462.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,25CRT@186801|Clostridia	186801|Clostridia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_6042143_24	867845.KI911784_gene3184	2.683e-26	114.0	COG0425@1|root,COG0425@2|Bacteria,2G7DF@200795|Chloroflexi,377DX@32061|Chloroflexia	32061|Chloroflexia	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
HKD1_k127_6042143_19	926550.CLDAP_30490	8.577e-64	224.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD1_k127_6042143_29	290317.Cpha266_2224	6.696e-06	52.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_6042143_17	1501230.ET33_08105	3.559e-75	266.0	COG1063@1|root,COG1063@2|Bacteria,1TPWP@1239|Firmicutes,4IPQ3@91061|Bacilli,2769W@186822|Paenibacillaceae	91061|Bacilli	E	alcohol dehydrogenase	gutB	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6042143_2	1303518.CCALI_01058	7.618e-162	517.0	COG1522@1|root,COG1522@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	nirH	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
HKD1_k127_6042143_28	1185652.USDA257_c12700	3.396e-13	74.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,4B93B@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_6042143_16	1168034.FH5T_06465	1.306e-76	263.0	COG3340@1|root,COG3340@2|Bacteria,4NEXW@976|Bacteroidetes,2FQTC@200643|Bacteroidia	976|Bacteroidetes	E	Belongs to the peptidase S51 family	pepE	-	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD1_k127_6042143_1	290397.Adeh_2108	3.323e-168	537.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,42PQY@68525|delta/epsilon subdivisions,2WJXE@28221|Deltaproteobacteria,2YUH0@29|Myxococcales	28221|Deltaproteobacteria	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_6042143_15	234267.Acid_5133	2.855e-84	291.0	COG1052@1|root,COG1052@2|Bacteria	2|Bacteria	CH	NAD binding	serA5	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_6042143_6	1123508.JH636439_gene1087	1.831e-128	424.0	COG0001@1|root,COG0001@2|Bacteria,2IX4X@203682|Planctomycetes	203682|Planctomycetes	H	COG0001 Glutamate-1-semialdehyde aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_6042143_14	177437.HRM2_34570	4.445e-98	335.0	COG0477@1|root,COG2814@2|Bacteria,1R9V9@1224|Proteobacteria,42Q1C@68525|delta/epsilon subdivisions,2WK7P@28221|Deltaproteobacteria,2MMQA@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD1_k127_6042143_5	330214.NIDE0204	2.75e-130	424.0	COG1683@1|root,COG3272@1|root,COG1683@2|Bacteria,COG3272@2|Bacteria,3J13F@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
HKD1_k127_6042143_7	1340493.JNIF01000003_gene2831	2.183e-127	427.0	COG0415@1|root,COG0415@2|Bacteria,3Y31R@57723|Acidobacteria	57723|Acidobacteria	L	PFAM DNA photolyase, FAD-binding	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD1_k127_6042143_11	671143.DAMO_2354	2.321e-116	381.0	COG1090@1|root,COG1090@2|Bacteria,2NPHC@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
HKD1_k127_6054863_0	671143.DAMO_0060	7.791e-252	788.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,2NNS8@2323|unclassified Bacteria	2|Bacteria	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	GO:0003674,GO:0003824,GO:0003916,GO:0003917,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051276,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360	5.99.1.2	ko:K03168,ko:K07479	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,zf-C4_Topoisom
HKD1_k127_6054863_3	671143.DAMO_0059	7.305e-92	315.0	COG0272@1|root,COG0758@1|root,COG0272@2|Bacteria,COG0758@2|Bacteria,2NP2V@2323|unclassified Bacteria	2|Bacteria	LU	DNA recombination-mediator protein A	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	2.7.7.7,6.5.1.2	ko:K01972,ko:K02342,ko:K04096	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03430,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03430,map03440	M00260	R00375,R00376,R00377,R00378,R00382	RC00005,RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,DNA_processg_A,HHH_2,HHH_5
HKD1_k127_6054863_7	1232410.KI421412_gene200	8.252e-30	136.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,42QS9@68525|delta/epsilon subdivisions,2WN3H@28221|Deltaproteobacteria,43SES@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_6054863_4	671143.DAMO_0058	1.096e-78	275.0	COG1686@1|root,COG1686@2|Bacteria,2NPJT@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	dacA	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD1_k127_6054863_6	224324.aq_908	7.667e-57	204.0	COG0279@1|root,COG0279@2|Bacteria,2G410@200783|Aquificae	200783|Aquificae	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD1_k127_6054863_1	696281.Desru_3272	5.28e-146	482.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,25ZYA@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
HKD1_k127_6054863_2	671143.DAMO_0056	2.111e-121	396.0	COG0341@1|root,COG0341@2|Bacteria,2NP4P@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K03074,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_6054863_5	671143.DAMO_0055	2.904e-58	204.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_6054866_0	671143.DAMO_0054	1.627e-199	634.0	COG1982@1|root,COG1982@2|Bacteria,2NNUZ@2323|unclassified Bacteria	2|Bacteria	E	Orn/Lys/Arg decarboxylase, C-terminal domain	speA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008923,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564	4.1.1.18,4.1.1.19	ko:K01582,ko:K01585	ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110	M00133	R00462,R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HKD1_k127_6054866_1	671143.DAMO_0055	1.259e-146	479.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_6064434_2	1144343.PMI41_00509	1.373e-53	195.0	COG1670@1|root,COG1670@2|Bacteria,1RABT@1224|Proteobacteria,2U6PR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	Acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_6064434_9	1499967.BAYZ01000156_gene556	1.245e-09	67.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K20444	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD1_k127_6064434_5	35754.JNYJ01000014_gene4761	2.674e-34	138.0	COG1832@1|root,COG1832@2|Bacteria,2IJYY@201174|Actinobacteria	201174|Actinobacteria	S	PFAM CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_6064434_8	1243664.CAVL020000016_gene1988	1.915e-16	87.0	COG1335@1|root,COG1335@2|Bacteria,1VEGS@1239|Firmicutes,4HR3B@91061|Bacilli,1ZHUU@1386|Bacillus	91061|Bacilli	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD1_k127_6064434_6	1408473.JHXO01000007_gene748	1.192e-24	107.0	2E69N@1|root,330XJ@2|Bacteria,4NYHG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6064434_7	331869.BAL199_12461	9.116e-18	85.0	2EIDG@1|root,33C4V@2|Bacteria,1N0P4@1224|Proteobacteria,2UC9K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6064434_4	118173.KB235914_gene1774	5.898e-35	139.0	COG2771@1|root,COG2771@2|Bacteria,1GEA5@1117|Cyanobacteria	1117|Cyanobacteria	K	Protein of unknown function (DUF4019)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019
HKD1_k127_6064434_0	671143.DAMO_2318	7.826e-191	604.0	COG0019@1|root,COG0019@2|Bacteria,2NNQK@2323|unclassified Bacteria	2|Bacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.1.129,3.4.16.4,4.1.1.20	ko:K01586,ko:K05366	ko00300,ko00550,ko01100,ko01110,ko01120,ko01130,ko01230,ko01501,map00300,map00550,map01100,map01110,map01120,map01130,map01230,map01501	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000,ko01003,ko01011	-	GT51	iLJ478.TM1517	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_6064434_1	671143.DAMO_2316	1.773e-146	469.0	COG0329@1|root,COG0329@2|Bacteria,2NP5Q@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_6064434_3	330214.NIDE0490	2.303e-50	185.0	COG0289@1|root,COG0289@2|Bacteria,3J0IJ@40117|Nitrospirae	40117|Nitrospirae	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD1_k127_6089864_0	765914.ThisiDRAFT_2702	1.13e-17	91.0	COG3385@1|root,COG3385@2|Bacteria,1QFKR@1224|Proteobacteria,1SCE4@1236|Gammaproteobacteria,1X0CD@135613|Chromatiales	135613|Chromatiales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_6089864_1	686340.Metal_3215	2.37e-17	89.0	COG3385@1|root,COG3385@2|Bacteria,1QFKR@1224|Proteobacteria,1SCE4@1236|Gammaproteobacteria,1XGSH@135618|Methylococcales	135618|Methylococcales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6104047_2	1123371.ATXH01000002_gene333	5.121e-10	64.0	COG0793@1|root,COG0793@2|Bacteria,2GH5D@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_6104047_0	1121405.dsmv_1730	7.905e-42	172.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,42N32@68525|delta/epsilon subdivisions,2WKBN@28221|Deltaproteobacteria,2MI0S@213118|Desulfobacterales	28221|Deltaproteobacteria	D	PFAM peptidase	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23,SH3_3
HKD1_k127_6104047_1	269799.Gmet_1855	9.292e-31	126.0	COG2177@1|root,COG2177@2|Bacteria,1MU65@1224|Proteobacteria,43BBA@68525|delta/epsilon subdivisions,2X6QG@28221|Deltaproteobacteria,43T0S@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Part of the ABC transporter FtsEX involved in cellular division	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD1_k127_6106318_2	1469245.JFBG01000071_gene67	2.823e-119	394.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,1RYFV@1236|Gammaproteobacteria,1X10G@135613|Chromatiales	135613|Chromatiales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_6106318_1	1082933.MEA186_11046	4.219e-120	396.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2TU3A@28211|Alphaproteobacteria,43IH0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	PFAM Mandelate racemase muconate lactonizing	MA20_17725	-	4.2.1.156,4.2.1.42	ko:K20023	ko00053,map00053	-	R05608	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_6106318_9	309801.trd_1136	7.859e-09	57.0	COG0395@1|root,COG0395@2|Bacteria,2GBU5@200795|Chloroflexi,27YRY@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6106318_5	99598.Cal7507_2327	2.084e-78	277.0	COG2084@1|root,COG2084@2|Bacteria,1GFKR@1117|Cyanobacteria,1HMUH@1161|Nostocales	1117|Cyanobacteria	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
HKD1_k127_6106318_6	264198.Reut_B5423	1.599e-54	199.0	COG2085@1|root,COG2085@2|Bacteria,1RCXR@1224|Proteobacteria,2VVWU@28216|Betaproteobacteria,1K571@119060|Burkholderiaceae	28216|Betaproteobacteria	S	NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD1_k127_6106318_0	460265.Mnod_1229	7.937e-162	533.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,1JRBF@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	ATP ADP translocase	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	MFS_1,TLC
HKD1_k127_6106318_3	1123060.JONP01000004_gene705	1.467e-111	368.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2U0AU@28211|Alphaproteobacteria,2JQ9I@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0656 Aldo keto reductases, related to diketogulonate reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_6106318_4	264732.Moth_1000	8.625e-102	345.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,42FN6@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_6106318_8	1307759.JOMJ01000003_gene652	1.12e-33	137.0	COG0296@1|root,COG0296@2|Bacteria,1N8WX@1224|Proteobacteria,42VNQ@68525|delta/epsilon subdivisions,2WQ7J@28221|Deltaproteobacteria,2MC6I@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	PFAM Glycoside hydrolase, family 13	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,CBM_48
HKD1_k127_6106318_7	1463887.KL589982_gene4660	1.09e-53	195.0	COG1572@1|root,COG2706@1|root,COG1572@2|Bacteria,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Peptidase_S8,VCBS,fn3
HKD1_k127_6115185_0	671143.DAMO_1830	1.377e-98	351.0	COG0745@1|root,COG3829@1|root,COG4191@1|root,COG0745@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	nifL	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1
HKD1_k127_6124377_1	63737.Npun_F1045	1.018e-103	358.0	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria,1HR9W@1161|Nostocales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_6124377_0	880072.Desac_1402	0.0	1323.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,2MR8V@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_6127113_16	1173024.KI912149_gene5660	2.4e-45	167.0	COG0614@1|root,COG0614@2|Bacteria,1G71C@1117|Cyanobacteria	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_6127113_6	543728.Vapar_1368	5.364e-127	419.0	COG2271@1|root,COG2271@2|Bacteria,1QXP5@1224|Proteobacteria,2VQS7@28216|Betaproteobacteria,4AJBG@80864|Comamonadaceae	28216|Betaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6127113_0	671143.DAMO_0396	3.867e-312	968.0	COG0514@1|root,COG0514@2|Bacteria,2NNZU@2323|unclassified Bacteria	2|Bacteria	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD1_k127_6127113_3	323261.Noc_1555	4.83e-147	490.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,1WWVA@135613|Chromatiales	135613|Chromatiales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_6127113_7	1224318.DT73_24725	1.634e-126	429.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate	fadJ	GO:0003674,GO:0003824,GO:0003857,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0008692,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016856,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	1.1.1.35,4.2.1.17,5.1.2.3	ko:K01782	ko00071,ko00280,ko00281,ko00310,ko00362,ko00380,ko00410,ko00640,ko00650,ko00903,ko00930,ko01040,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00362,map00380,map00410,map00640,map00650,map00903,map00930,map01040,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R01975,R03026,R03045,R03276,R04137,R04170,R04203,R04204,R04224,R04737,R04738,R04739,R04740,R04741,R04744,R04745,R04746,R04748,R04749,R05066,R05305,R06411,R06412,R06941,R06942,R07935,R07951,R08093,R08094	RC00029,RC00099,RC00117,RC00241,RC00525,RC00831,RC00834,RC00896,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c26730,iETEC_1333.ETEC_2476,iEcE24377_1341.EcE24377A_2637,ic_1306.c2886	3HCDH,3HCDH_N,ECH_1
HKD1_k127_6127113_5	1379698.RBG1_1C00001G0786	3.236e-129	426.0	COG0183@1|root,COG0183@2|Bacteria,2NQJA@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	fadA	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_6127113_8	1121468.AUBR01000024_gene3021	1.961e-125	423.0	COG0318@1|root,COG0318@2|Bacteria,1TPSX@1239|Firmicutes,248JC@186801|Clostridia,42FN9@68295|Thermoanaerobacterales	186801|Clostridia	IQ	PFAM AMP-dependent synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD1_k127_6127113_17	1380350.JIAP01000021_gene276	5.963e-33	139.0	COG2021@1|root,COG2021@2|Bacteria,1QVBR@1224|Proteobacteria,2TWEP@28211|Alphaproteobacteria,43KK7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Serine aminopeptidase, S33	rutD	-	-	ko:K09023	ko00240,ko01100,map00240,map01100	-	R09983	RC02769	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_6127113_14	1089553.Tph_c04170	1.979e-55	197.0	COG1142@1|root,COG1142@2|Bacteria,1UHYS@1239|Firmicutes,24JZC@186801|Clostridia,42H3B@68295|Thermoanaerobacterales	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6,Fer4_9
HKD1_k127_6127113_1	1121033.AUCF01000016_gene5429	3.393e-275	857.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,2UPET@28211|Alphaproteobacteria,2JWPR@204441|Rhodospirillales	204441|Rhodospirillales	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_6127113_22	643648.Slip_2100	1.257e-16	82.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_6127113_2	1121033.AUCF01000016_gene5427	2.211e-192	619.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TRIR@28211|Alphaproteobacteria,2JQ76@204441|Rhodospirillales	204441|Rhodospirillales	CP	COG1009 NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	-	ko:K05559,ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
HKD1_k127_6127113_10	1121033.AUCF01000016_gene5426	4.001e-96	327.0	COG0651@1|root,COG0651@2|Bacteria	2|Bacteria	CP	ATP synthesis coupled electron transport	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD1_k127_6127113_13	1121033.AUCF01000016_gene5425	2.623e-57	205.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2U5HP@28211|Alphaproteobacteria,2JX6W@204441|Rhodospirillales	204441|Rhodospirillales	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_6127113_11	1121033.AUCF01000016_gene5424	2.831e-92	317.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria	1224|Proteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_6127113_20	1121033.AUCF01000016_gene5423	5.491e-23	105.0	COG1143@1|root,COG1143@2|Bacteria,1N025@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6,Fer4_7
HKD1_k127_6127113_21	1121033.AUCF01000016_gene5422	2.68e-18	90.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	hycE	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_6127113_4	1121033.AUCF01000016_gene5421	3.765e-146	471.0	COG3261@1|root,COG3261@2|Bacteria,1QUBF@1224|Proteobacteria,2TS6E@28211|Alphaproteobacteria,2JW0F@204441|Rhodospirillales	204441|Rhodospirillales	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_49kDa,NiFeSe_Hases
HKD1_k127_6127113_9	1298867.AUES01000089_gene2973	8.464e-113	374.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,3K2G8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_6127113_15	118168.MC7420_7794	6.537e-52	196.0	COG0469@1|root,COG0469@2|Bacteria,1G1KV@1117|Cyanobacteria	2|Bacteria	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
HKD1_k127_6127113_19	380358.XALC_2530	2.718e-26	112.0	2BH75@1|root,32B8F@2|Bacteria,1QB6K@1224|Proteobacteria,1T6QF@1236|Gammaproteobacteria,1X7EX@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6127113_18	1205753.A989_15557	2.261e-32	132.0	COG1664@1|root,COG1664@2|Bacteria,1MZG6@1224|Proteobacteria,1S826@1236|Gammaproteobacteria,1X74A@135614|Xanthomonadales	135614|Xanthomonadales	M	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_6127113_12	1121106.JQKB01000020_gene1981	3.571e-75	265.0	COG1893@1|root,COG1893@2|Bacteria,1MVZ1@1224|Proteobacteria,2TRJN@28211|Alphaproteobacteria,2JV65@204441|Rhodospirillales	204441|Rhodospirillales	H	Ketopantoate reductase PanE/ApbA C terminal	-	-	-	-	-	-	-	-	-	-	-	-	ApbA,ApbA_C
HKD1_k127_6132842_5	887062.HGR_08184	2.09e-75	263.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,2VKIK@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Dehydrogenase	garR	-	1.1.1.31,1.1.1.411	ko:K00020,ko:K08319	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_6132842_1	1304883.KI912532_gene297	6.17e-111	373.0	COG2358@1|root,COG2358@2|Bacteria,1PNJV@1224|Proteobacteria,2VI8H@28216|Betaproteobacteria,2KVEI@206389|Rhodocyclales	206389|Rhodocyclales	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD1_k127_6132842_3	1123508.JH636439_gene1018	1.836e-98	332.0	COG3391@1|root,COG3391@2|Bacteria,2J27D@203682|Planctomycetes	203682|Planctomycetes	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD1_k127_6132842_0	1121033.AUCF01000004_gene4871	2.296e-137	455.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2TTF4@28211|Alphaproteobacteria,2JRC2@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD1_k127_6132842_2	1279038.KB907349_gene3024	4.579e-107	356.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TRH6@28211|Alphaproteobacteria,2JPTF@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_6132842_4	1121033.AUCF01000004_gene4869	2.858e-91	326.0	COG1173@1|root,COG1173@2|Bacteria,1MVER@1224|Proteobacteria,2TRB3@28211|Alphaproteobacteria,2JQ5D@204441|Rhodospirillales	204441|Rhodospirillales	EP	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,OppC_N
HKD1_k127_6132842_6	1499967.BAYZ01000028_gene1366	3.827e-48	179.0	COG3653@1|root,COG3653@2|Bacteria,2NNQ0@2323|unclassified Bacteria	2|Bacteria	Q	Amidohydrolase family	dan	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD1_k127_6141720_40	671143.DAMO_0537	9.105e-12	70.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_6141720_33	1232410.KI421418_gene2109	2.471e-34	149.0	COG0457@1|root,COG0457@2|Bacteria,1QXNU@1224|Proteobacteria,43C4R@68525|delta/epsilon subdivisions,2X7F5@28221|Deltaproteobacteria,43SFM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Peptidase MA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_MA_2,TPR_16,TPR_2,TPR_8
HKD1_k127_6141720_41	1291050.JAGE01000001_gene648	9.358e-06	57.0	2DPV4@1|root,333HA@2|Bacteria,1VH7Z@1239|Firmicutes,24SC2@186801|Clostridia,3WQ8C@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6141720_23	671143.DAMO_0523	1.837e-65	238.0	COG0566@1|root,COG0566@2|Bacteria,2NPDE@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD1_k127_6141720_3	1499967.BAYZ01000148_gene1746	9.267e-150	490.0	COG0215@1|root,COG0215@2|Bacteria,2NNP0@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	GO:0000166,GO:0001871,GO:0003674,GO:0003824,GO:0004812,GO:0004817,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006423,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009986,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030246,GO:0030247,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2001065	6.1.1.16,6.3.1.13	ko:K01883,ko:K15526	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iECUMN_1333.ECUMN_0566,iJN746.PP_2905	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_6141720_30	760568.Desku_3146	3.059e-52	190.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,26109@186807|Peptococcaceae	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD1_k127_6141720_25	868595.Desca_0181	3.075e-59	214.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,261YY@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
HKD1_k127_6141720_11	671143.DAMO_0519	1.351e-116	389.0	COG4956@1|root,COG4956@2|Bacteria,2NP0D@2323|unclassified Bacteria	2|Bacteria	S	Large family of predicted nucleotide-binding domains	yacL	GO:0005575,GO:0005618,GO:0005623,GO:0030312,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
HKD1_k127_6141720_24	671143.DAMO_0518	7.951e-61	215.0	COG1329@1|root,COG1329@2|Bacteria,2NPWZ@2323|unclassified Bacteria	2|Bacteria	K	CarD-like/TRCF domain	carD	GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009405,GO:0009605,GO:0009987,GO:0009991,GO:0015968,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0040007,GO:0042594,GO:0044419,GO:0050896,GO:0051704,GO:0051716,GO:0071496	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD1_k127_6141720_6	330214.NIDE1676	7.062e-138	454.0	COG1066@1|root,COG1066@2|Bacteria,3J0BP@40117|Nitrospirae	40117|Nitrospirae	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI,Lon_C
HKD1_k127_6141720_22	269799.Gmet_1272	4.762e-71	254.0	COG1463@1|root,COG1463@2|Bacteria,1MY8D@1224|Proteobacteria,42TCA@68525|delta/epsilon subdivisions,2WP6I@28221|Deltaproteobacteria,43UDZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_6141720_18	1232410.KI421421_gene3418	4.433e-82	280.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42YJC@68525|delta/epsilon subdivisions,2WTKU@28221|Deltaproteobacteria,43TDB@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_6141720_20	1232410.KI421421_gene3417	7.753e-76	268.0	COG0767@1|root,COG0767@2|Bacteria,1RHNJ@1224|Proteobacteria,42SNW@68525|delta/epsilon subdivisions,2WPKT@28221|Deltaproteobacteria,43T2D@69541|Desulfuromonadales	28221|Deltaproteobacteria	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_6141720_19	269799.Gmet_1270	7.425e-76	278.0	COG3170@1|root,COG3170@2|Bacteria,1MY6X@1224|Proteobacteria,42TBE@68525|delta/epsilon subdivisions,2WPBV@28221|Deltaproteobacteria,43U5N@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6141720_0	671143.DAMO_0515	3.152e-185	589.0	COG0305@1|root,COG0305@2|Bacteria,2NNKG@2323|unclassified Bacteria	2|Bacteria	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD1_k127_6141720_34	671143.DAMO_0514	2.72e-33	135.0	COG0359@1|root,COG0359@2|Bacteria,2NPX4@2323|unclassified Bacteria	2|Bacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016020,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD1_k127_6141720_32	671143.DAMO_0513	1.338e-36	157.0	COG4241@1|root,COG4241@2|Bacteria	2|Bacteria	S	Predicted membrane protein (DUF2232)	yybS	-	-	ko:K16785,ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	DUF2232
HKD1_k127_6141720_36	671143.DAMO_0512	3.961e-29	118.0	COG0238@1|root,COG0238@2|Bacteria,2NPTU@2323|unclassified Bacteria	2|Bacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0022626,GO:0022627,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD1_k127_6141720_29	671143.DAMO_0511	1.785e-55	200.0	COG0629@1|root,COG0629@2|Bacteria,2NPP5@2323|unclassified Bacteria	2|Bacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD1_k127_6141720_38	671143.DAMO_0510	4.827e-25	108.0	COG0360@1|root,COG0360@2|Bacteria,2NQ1Q@2323|unclassified Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0019538,GO:0019843,GO:0022626,GO:0022627,GO:0030312,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048027,GO:0070181,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	4.3.1.19	ko:K01754,ko:K02990	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,ko03010,map00260,map00290,map01100,map01110,map01130,map01200,map01230,map03010	M00178,M00570	R00220,R00996	RC00418,RC02600	br01610,ko00000,ko00001,ko00002,ko01000,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD1_k127_6141720_31	1123371.ATXH01000007_gene552	3.07e-50	185.0	COG0193@1|root,COG0193@2|Bacteria,2GGV1@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD1_k127_6141720_26	671143.DAMO_0508	1.127e-57	209.0	COG1825@1|root,COG1825@2|Bacteria,2NPVU@2323|unclassified Bacteria	2|Bacteria	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008097,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD1_k127_6141720_7	671143.DAMO_0507	1.686e-137	444.0	COG0462@1|root,COG0462@2|Bacteria,2NNP6@2323|unclassified Bacteria	2|Bacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	GO:0003674,GO:0003824,GO:0004749,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016772,GO:0016778,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2848	Pribosyl_synth,Pribosyltran_N
HKD1_k127_6141720_28	195250.CM001776_gene176	7.808e-56	205.0	COG1947@1|root,COG1947@2|Bacteria,1G0YY@1117|Cyanobacteria,1GZVI@1129|Synechococcus	1117|Cyanobacteria	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0044237,GO:0050515	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_6141720_39	671143.DAMO_0504	4.234e-15	85.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	DUF4292,LolA
HKD1_k127_6141720_1	671143.DAMO_0503	7.4e-167	544.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,2NPEN@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	ko:K11935	ko02026,map02026	-	-	-	ko00000,ko00001	-	-	-	TPR_1,TPR_15,TPR_16,TPR_19,TPR_2,TPR_7,TPR_8
HKD1_k127_6141720_27	643648.Slip_0316	9.3e-57	205.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,42JZD@68298|Syntrophomonadaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD1_k127_6141720_35	1297617.JPJD01000020_gene408	3.469e-32	131.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,2692N@186813|unclassified Clostridiales	186801|Clostridia	S	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_6141720_37	1499967.BAYZ01000118_gene3301	9.65e-26	109.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HKD1_k127_6141720_8	292459.STH1422	1.101e-128	430.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia	186801|Clostridia	E	Family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_6141720_16	292459.STH1424	1.728e-96	326.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia	186801|Clostridia	P	ABC-type dipeptide oligopeptide nickel transport	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_6141720_13	883080.HMPREF9697_03463	3.664e-102	342.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TT48@28211|Alphaproteobacteria,3JSZX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_6141720_21	1449126.JQKL01000011_gene3586	1.099e-71	253.0	COG0327@1|root,COG0327@2|Bacteria,1UK7Y@1239|Firmicutes,248IP@186801|Clostridia	186801|Clostridia	S	PFAM NIF3 (NGG1p interacting factor 3)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6141720_2	986075.CathTA2_1937	9.706e-162	522.0	COG0624@1|root,COG0624@2|Bacteria,1TP2D@1239|Firmicutes,4HB9G@91061|Bacilli	91061|Bacilli	E	COG0624, acetylornithine deacetylase succinyl-diaminopimelate desuccinylase and related deacylases	dapE	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_6141720_15	1449063.JMLS01000025_gene4028	5.246e-98	328.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HBB9@91061|Bacilli,26Q9W@186822|Paenibacillaceae	91061|Bacilli	EP	ABC transporter permease	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_6141720_12	1449063.JMLS01000025_gene4029	3.792e-104	346.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,4HBED@91061|Bacilli,26RTC@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_6141720_10	1150474.JQJI01000033_gene1644	6.782e-124	417.0	COG0747@1|root,COG0747@2|Bacteria,2GDVM@200918|Thermotogae	200918|Thermotogae	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_6141720_17	935948.KE386495_gene1413	3.202e-93	315.0	COG1082@1|root,COG1082@2|Bacteria,1TRGF@1239|Firmicutes,248GM@186801|Clostridia,42FYQ@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Xylose isomerase domain-containing protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_6141720_5	331869.BAL199_00590	3.004e-138	453.0	COG1653@1|root,COG1653@2|Bacteria,1MU64@1224|Proteobacteria,2TTUB@28211|Alphaproteobacteria,4BRJR@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8,TAT_signal
HKD1_k127_6141720_9	1040989.AWZU01000003_gene6624	5.462e-126	415.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TZRR@28211|Alphaproteobacteria,3JTDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6141720_4	1038860.AXAP01000107_gene4558	9.193e-141	458.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,2U0UX@28211|Alphaproteobacteria,3JWP8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6141720_14	861299.J421_0447	4.491e-102	339.0	COG2107@1|root,COG2107@2|Bacteria,1ZTVU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD1_k127_6148453_0	471855.Shel_04450	1.282e-102	357.0	COG2414@1|root,COG2414@2|Bacteria,2IF1J@201174|Actinobacteria,4CV7Z@84998|Coriobacteriia	84998|Coriobacteriia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_6148453_2	631454.N177_3820	8.17e-38	149.0	COG5276@1|root,COG5276@2|Bacteria,1MU72@1224|Proteobacteria,2TZVG@28211|Alphaproteobacteria,1JQCV@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HKD1_k127_6148453_1	338963.Pcar_1084	2.331e-69	241.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,43UIC@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_6157803_13	671143.DAMO_0537	3.702e-12	66.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_6157803_10	1504822.CCNO01000011_gene162	2.418e-19	88.0	COG0267@1|root,COG0267@2|Bacteria,2NQ3R@2323|unclassified Bacteria	2|Bacteria	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD1_k127_6157803_11	671143.DAMO_0526	3.521e-14	77.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD1_k127_6157803_4	671143.DAMO_0527	5.174e-88	301.0	COG0250@1|root,COG0250@2|Bacteria,2NPAP@2323|unclassified Bacteria	2|Bacteria	K	Participates in transcription elongation, termination and antitermination	nusG	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006353,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043244,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD1_k127_6157803_6	671143.DAMO_0528	1.864e-68	234.0	COG0080@1|root,COG0080@2|Bacteria,2NP7W@2323|unclassified Bacteria	2|Bacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006415,GO:0006518,GO:0006807,GO:0006950,GO:0006996,GO:0007154,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0010467,GO:0015934,GO:0015968,GO:0016043,GO:0019538,GO:0019843,GO:0022411,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0032984,GO:0032991,GO:0033554,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042273,GO:0042594,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0065003,GO:0070925,GO:0071496,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD1_k127_6157803_3	671143.DAMO_0529	3.918e-110	361.0	COG0081@1|root,COG0081@2|Bacteria,2NNK6@2323|unclassified Bacteria	2|Bacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD1_k127_6157803_9	644966.Tmar_2305	1.449e-40	156.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,3WCJV@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD1_k127_6157803_8	671143.DAMO_0531	4.564e-49	179.0	COG0222@1|root,COG0222@2|Bacteria,2NPJ4@2323|unclassified Bacteria	2|Bacteria	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD1_k127_6157803_1	1232410.KI421428_gene1223	0.0	1615.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,43DMZ@68525|delta/epsilon subdivisions,2WIW5@28221|Deltaproteobacteria,43SCN@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	RNA polymerase beta subunit external 1 domain	rpoB	GO:0000428,GO:0005575,GO:0005622,GO:0005623,GO:0030880,GO:0032991,GO:0044424,GO:0044464,GO:0061695,GO:1902494,GO:1990234	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_6157803_0	671143.DAMO_0533	0.0	2166.0	COG0086@1|root,COG0086@2|Bacteria,2NNPR@2323|unclassified Bacteria	2|Bacteria	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	GO:0000428,GO:0003674,GO:0003824,GO:0003899,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0030880,GO:0032774,GO:0032991,GO:0034062,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:0097659,GO:0097747,GO:0140098,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.6	ko:K03046,ko:K13797	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD1_k127_6157803_7	671143.DAMO_0534	3.606e-62	216.0	COG0048@1|root,COG0048@2|Bacteria,2NPA7@2323|unclassified Bacteria	2|Bacteria	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD1_k127_6157803_5	671143.DAMO_0535	9.427e-71	243.0	COG0049@1|root,COG0049@2|Bacteria,2NP7H@2323|unclassified Bacteria	2|Bacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015935,GO:0016020,GO:0016043,GO:0017148,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD1_k127_6157803_2	671143.DAMO_0536	0.0	1019.0	COG0480@1|root,COG0480@2|Bacteria,2NNSV@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0030312,GO:0034641,GO:0034645,GO:0040007,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_6157803_12	671143.DAMO_0537	6.303e-13	70.0	COG0050@1|root,COG0050@2|Bacteria,2NNQV@2323|unclassified Bacteria	2|Bacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_6169783_1	1121472.AQWN01000001_gene137	2.83e-222	702.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,260ER@186807|Peptococcaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD1_k127_6169783_8	671143.DAMO_0575	1.255e-32	131.0	COG1550@1|root,COG1550@2|Bacteria,2NPYX@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF503)	ylxP	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HKD1_k127_6169783_9	1266914.ATUK01000012_gene60	3.876e-23	104.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1WYHM@135613|Chromatiales	135613|Chromatiales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD1_k127_6169783_5	867903.ThesuDRAFT_00231	2.355e-67	241.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,3WCIW@538999|Clostridiales incertae sedis	186801|Clostridia	S	DHH family	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_6169783_3	671143.DAMO_0578	5.658e-117	385.0	COG0130@1|root,COG0130@2|Bacteria,2NP9J@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0000049,GO:0001522,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0031119,GO:0034337,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD1_k127_6169783_4	671143.DAMO_0579	2.361e-79	275.0	COG0196@1|root,COG0196@2|Bacteria,2NPCV@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K07011,ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS06310	FAD_syn,Flavokinase
HKD1_k127_6169783_7	671143.DAMO_0580	9.88e-35	135.0	COG0184@1|root,COG0184@2|Bacteria,2NPTZ@2323|unclassified Bacteria	2|Bacteria	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016020,GO:0016043,GO:0016070,GO:0016071,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0031123,GO:0031124,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD1_k127_6169783_0	671143.DAMO_0581	1.145e-304	952.0	COG1185@1|root,COG1185@2|Bacteria,2NNX7@2323|unclassified Bacteria	2|Bacteria	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	GO:0000166,GO:0000175,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004518,GO:0004527,GO:0004532,GO:0004540,GO:0004654,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006401,GO:0006402,GO:0006725,GO:0006807,GO:0006950,GO:0008144,GO:0008150,GO:0008152,GO:0008408,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009987,GO:0010468,GO:0010605,GO:0010629,GO:0016020,GO:0016070,GO:0016071,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0016796,GO:0016896,GO:0017076,GO:0019001,GO:0019222,GO:0019439,GO:0030312,GO:0030551,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034655,GO:0035438,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0050896,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0097159,GO:0097367,GO:0140098,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901575	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_6169783_2	671143.DAMO_0582	2.301e-164	533.0	COG0612@1|root,COG0612@2|Bacteria,2NNW3@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the peptidase M16 family	pepR	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_6169783_10	765869.BDW_09010	5.374e-08	61.0	2ECCV@1|root,336B4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
HKD1_k127_6169783_11	292564.Cyagr_2382	3.938e-06	55.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,22TC6@167375|Cyanobium	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_6169783_6	1206737.BAGF01000062_gene4155	9.313e-59	207.0	COG5646@1|root,COG5646@2|Bacteria,2IINN@201174|Actinobacteria,4G0JA@85025|Nocardiaceae	201174|Actinobacteria	S	InterPro IPR014922	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD1_k127_6182451_1	1125863.JAFN01000001_gene2253	2.295e-105	357.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6182451_4	420662.Mpe_A2536	6.14e-26	112.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2W1N6@28216|Betaproteobacteria,1KNUP@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_6182451_2	359.CN09_20655	5.57e-65	233.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,4BBK0@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	nodW	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_6182451_0	1502851.FG93_00154	2.982e-168	582.0	COG3850@1|root,COG4191@1|root,COG3850@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
HKD1_k127_6182451_3	420324.KI911963_gene358	6.438e-40	154.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,1JSTD@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K13040	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_6182451_5	113395.AXAI01000021_gene3450	2.491e-18	90.0	COG4251@1|root,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWHG@28211|Alphaproteobacteria,3JTJ6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF,HATPase_c,HisKA,PAS_2,PHY,Response_reg
HKD1_k127_6182451_6	545695.TREAZ_2783	9.189e-07	52.0	COG2204@1|root,COG2204@2|Bacteria,2J6EQ@203691|Spirochaetes	203691|Spirochaetes	T	response regulator	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6199877_4	688269.Theth_1319	4.084e-96	325.0	COG3653@1|root,COG3653@2|Bacteria	2|Bacteria	Q	N-Acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD1_k127_6199877_6	1210884.HG799465_gene11942	8.874e-71	254.0	COG3616@1|root,COG3616@2|Bacteria,2IYAY@203682|Planctomycetes	203682|Planctomycetes	E	amino acid aldolase or racemase	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HKD1_k127_6199877_2	1499967.BAYZ01000195_gene3111	1.667e-129	424.0	COG0667@1|root,COG0667@2|Bacteria	2|Bacteria	C	Aldo Keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_6199877_5	1123371.ATXH01000001_gene1185	3.294e-83	284.0	COG0655@1|root,COG0655@2|Bacteria,2GHPQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_6199877_3	1121468.AUBR01000004_gene204	1.282e-103	353.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,42FVU@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K13954,ko:K19954	ko00010,ko00071,ko00350,ko00625,ko00626,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R04880,R05233,R05234,R06917,R06927	RC00050,RC00088,RC00099,RC00116,RC00649	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_6199877_0	1163617.SCD_n02853	9.785e-173	548.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,2VK7J@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_6199877_9	266117.Rxyl_2933	2.155e-38	163.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,2GJZH@201174|Actinobacteria	201174|Actinobacteria	S	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD1_k127_6199877_10	1304874.JAFY01000002_gene1029	1.236e-36	149.0	COG0639@1|root,COG2206@1|root,COG0639@2|Bacteria,COG2206@2|Bacteria	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	MA20_24125	-	3.6.1.11,3.6.1.40	ko:K01524,ko:K07012	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000,ko02048	-	-	-	HD,Metallophos_2
HKD1_k127_6199877_7	768710.DesyoDRAFT_2585	1.885e-57	209.0	COG2227@1|root,COG2227@2|Bacteria,1UN1H@1239|Firmicutes	1239|Firmicutes	H	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_6199877_8	936455.KI421499_gene215	2.568e-56	206.0	COG1028@1|root,COG1028@2|Bacteria,1NBB6@1224|Proteobacteria,2TVF5@28211|Alphaproteobacteria,3JXK5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD1_k127_6199877_1	525897.Dbac_1404	7.851e-161	516.0	COG0683@1|root,COG0683@2|Bacteria,1MX94@1224|Proteobacteria,42PYP@68525|delta/epsilon subdivisions,2WMA1@28221|Deltaproteobacteria,2M979@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6199877_11	1232410.KI421428_gene1073	3.739e-30	121.0	COG1541@1|root,COG1541@2|Bacteria,1MXF5@1224|Proteobacteria,42MZA@68525|delta/epsilon subdivisions,2WIUC@28221|Deltaproteobacteria,43S2I@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	AMP-binding enzyme C-terminal domain	paaK-3	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_6207835_4	113395.AXAI01000014_gene156	3.489e-85	289.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,3JQRS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6207835_6	1298867.AUES01000001_gene1861	1.924e-74	272.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2TVRQ@28211|Alphaproteobacteria,3K5X3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6207835_3	1298867.AUES01000001_gene1862	7.094e-88	301.0	COG4177@1|root,COG4177@2|Bacteria,1R65P@1224|Proteobacteria,2TU6V@28211|Alphaproteobacteria,3JSC0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6207835_2	1297865.APJD01000007_gene2316	4.836e-89	303.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,3JS3Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6207835_1	1122915.AUGY01000120_gene460	6.233e-118	395.0	COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes,4I77Z@91061|Bacilli,272NN@186822|Paenibacillaceae	91061|Bacilli	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_6207835_9	388401.RB2150_02284	3.783e-59	215.0	COG1028@1|root,COG1028@2|Bacteria,1Q7EW@1224|Proteobacteria	1224|Proteobacteria	IQ	Short-chain dehydrogenase reductase Sdr	yohF	-	1.1.1.100,1.1.1.304,1.1.1.47,1.1.1.76	ko:K00034,ko:K00059,ko:K03366	ko00030,ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01120,ko01130,ko01200,ko01212,map00030,map00061,map00333,map00650,map00780,map01040,map01100,map01120,map01130,map01200,map01212	M00083,M00572	R01520,R01521,R02855,R02946,R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R11671	RC00029,RC00066,RC00117,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6207835_0	891968.Anamo_0095	7.271e-201	644.0	COG2414@1|root,COG2414@2|Bacteria,3TAA6@508458|Synergistetes	508458|Synergistetes	C	PFAM Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_6207835_10	1304880.JAGB01000001_gene562	1.158e-27	128.0	COG1653@1|root,COG1653@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K02025,ko:K02027,ko:K10118	ko02010,map02010	M00196,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.28	-	-	BPD_transp_1,SBP_bac_1,SBP_bac_8
HKD1_k127_6207835_7	1158606.I579_00125	6.893e-68	243.0	COG1175@1|root,COG1175@2|Bacteria,1TPMR@1239|Firmicutes,4HA5B@91061|Bacilli,4B20F@81852|Enterococcaceae	91061|Bacilli	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6207835_8	743719.PaelaDRAFT_4311	1.525e-62	225.0	COG0395@1|root,COG0395@2|Bacteria,1TRCP@1239|Firmicutes,4HBKE@91061|Bacilli,26TAK@186822|Paenibacillaceae	91061|Bacilli	P	Sugar ABC transporter permease	malF	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
HKD1_k127_6207835_5	370438.PTH_1185	1.092e-79	282.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,2611N@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	gabT	-	2.6.1.19,2.6.1.22	ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iHN637.CLJU_RS10045	Aminotran_3
HKD1_k127_6207835_11	1205680.CAKO01000029_gene5031	4.477e-08	57.0	COG1921@1|root,COG1921@2|Bacteria,1MW8F@1224|Proteobacteria,2TSR8@28211|Alphaproteobacteria,2JYRT@204441|Rhodospirillales	204441|Rhodospirillales	E	L-seryl-tRNA selenium transferase	-	-	-	-	-	-	-	-	-	-	-	-	SelA
HKD1_k127_6220971_2	189753.AXAS01000041_gene2534	5.806e-53	196.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_6220971_0	189753.AXAS01000041_gene2534	1.067e-76	271.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_6220971_1	246197.MXAN_3613	2.908e-69	255.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,42QTE@68525|delta/epsilon subdivisions,2WN61@28221|Deltaproteobacteria,2YUPI@29|Myxococcales	28221|Deltaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
HKD1_k127_6221714_5	1267534.KB906755_gene4672	1.43e-05	51.0	COG1538@1|root,COG1538@2|Bacteria,3Y48M@57723|Acidobacteria,2JIRF@204432|Acidobacteriia	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_6221714_2	107636.JQNK01000006_gene930	5.275e-95	316.0	COG3316@1|root,COG5433@1|root,COG3316@2|Bacteria,COG5433@2|Bacteria,1MWZ2@1224|Proteobacteria,2U2PF@28211|Alphaproteobacteria,36ZM0@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_6221714_1	1121033.AUCF01000014_gene1223	1.583e-95	323.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2TWCZ@28211|Alphaproteobacteria,2JYV3@204441|Rhodospirillales	204441|Rhodospirillales	CI	phosphate acetyltransferase	-	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD1_k127_6221714_0	1397528.Q671_16165	0.0	1025.0	COG3243@1|root,COG3243@2|Bacteria,1MUNE@1224|Proteobacteria,1RNZI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Protein of unknown function (DUF3141)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3141
HKD1_k127_6221714_3	232721.Ajs_2362	7.01e-39	146.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2VHRI@28216|Betaproteobacteria,4AC10@80864|Comamonadaceae	28216|Betaproteobacteria	V	PFAM ABC-2 type transporter	yhhJ	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_6223034_0	671143.DAMO_0583	4.625e-189	601.0	COG0015@1|root,COG0015@2|Bacteria,2NP0M@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	GO:0003674,GO:0003824,GO:0004018,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016840,GO:0016842,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046033,GO:0046390,GO:0046483,GO:0055086,GO:0070626,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1095,iSB619.SA_RS09895	ADSL_C,Lyase_1
HKD1_k127_6223034_1	370438.PTH_2546	2.971e-72	252.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,2619J@186807|Peptococcaceae	186801|Clostridia	F	PFAM SAICAR synthetase	purC	-	4.3.2.2,6.3.2.6	ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD1_k127_6223034_2	1089553.Tph_c08440	7.739e-09	66.0	COG1828@1|root,COG1828@2|Bacteria,1VEH1@1239|Firmicutes,24R3W@186801|Clostridia,42H8G@68295|Thermoanaerobacterales	186801|Clostridia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD1_k127_6234176_0	331869.BAL199_00645	7.924e-177	564.0	COG3385@1|root,COG3385@2|Bacteria,1QURV@1224|Proteobacteria,2TW56@28211|Alphaproteobacteria,4BSI7@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2183 Transcriptional accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD1_k127_6242163_4	1192034.CAP_3936	8.567e-08	58.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_8
HKD1_k127_6242163_3	867903.ThesuDRAFT_01469	1.762e-64	232.0	COG4221@1|root,COG4221@2|Bacteria,1TQDY@1239|Firmicutes,24KK5@186801|Clostridia	186801|Clostridia	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6242163_2	1174528.JH992892_gene6289	3.226e-66	235.0	COG0500@1|root,COG2226@2|Bacteria,1G364@1117|Cyanobacteria	1117|Cyanobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_6242163_0	926569.ANT_25440	1.109e-89	304.0	COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi	200795|Chloroflexi	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6242163_1	305900.GV64_10055	2.569e-69	247.0	COG1028@1|root,COG1028@2|Bacteria,1QTUD@1224|Proteobacteria,1T1HG@1236|Gammaproteobacteria,1XKI2@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6243101_6	661478.OP10G_1547	1.931e-124	406.0	COG1409@1|root,COG3794@1|root,COG1409@2|Bacteria,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1,Metallophos
HKD1_k127_6243101_17	883080.HMPREF9697_00614	9.743e-26	111.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,3JYXK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD1_k127_6243101_15	1279009.ADICEAN_00819	2.55e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,4NEFR@976|Bacteroidetes,47JFG@768503|Cytophagia	976|Bacteroidetes	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6243101_16	1151127.KB906339_gene905	7.349e-29	128.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,1SFJZ@1236|Gammaproteobacteria,1YTFZ@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6243101_1	671143.DAMO_2498	2.848e-165	526.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_6243101_18	1133569.AHYZ01000045_gene1418	8.632e-16	90.0	COG0477@1|root,COG2814@2|Bacteria,1TRDJ@1239|Firmicutes,4H9Q9@91061|Bacilli,3F3T5@33958|Lactobacillaceae	91061|Bacilli	EGP	Transporter, major facilitator family protein	mdtG	-	-	ko:K08161	-	-	-	-	ko00000,ko02000	2.A.1.2.20	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_6243101_0	37919.EP51_18690	4.547e-190	612.0	COG0028@1|root,COG0028@2|Bacteria,2I9V6@201174|Actinobacteria,4G67U@85025|Nocardiaceae	201174|Actinobacteria	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_6243101_13	663278.Ethha_1696	1.384e-42	173.0	COG0477@1|root,COG2814@2|Bacteria,1V0Z5@1239|Firmicutes,24B0J@186801|Clostridia	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_6243101_3	697281.Mahau_0740	1.788e-147	479.0	COG1904@1|root,COG1904@2|Bacteria,1TR4T@1239|Firmicutes,249B2@186801|Clostridia,42F7V@68295|Thermoanaerobacterales	186801|Clostridia	G	glucuronate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6243101_14	1499967.BAYZ01000095_gene4299	6.27e-40	153.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	MA20_40115	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_6243101_11	1499967.BAYZ01000117_gene3303	1.211e-45	178.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_6243101_2	1499967.BAYZ01000184_gene4609	6.112e-160	512.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_6243101_5	368408.Tpen_0821	4.82e-137	447.0	COG1063@1|root,arCOG01459@2157|Archaea	2157|Archaea	C	Catalyzes the NAD(P)( )-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD( ) and NADP( ) as electron acceptor. Is involved in the degradation of glucose through a	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6243101_10	525904.Tter_1521	3.726e-76	270.0	COG1082@1|root,COG1082@2|Bacteria,2NR3H@2323|unclassified Bacteria	2|Bacteria	G	Xylose isomerase-like TIM barrel	iolE	-	1.1.1.18,1.1.1.369,4.2.1.44	ko:K00010,ko:K03335	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R02782,R05659,R09951	RC00182,RC00782,RC01448	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_6243101_8	1347368.HG964403_gene3963	2.566e-101	338.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,4HD97@91061|Bacilli,1ZC66@1386|Bacillus	91061|Bacilli	G	COG3959 Transketolase, N-terminal subunit	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_6243101_7	525904.Tter_1527	5.273e-110	364.0	COG3958@1|root,COG3958@2|Bacteria,2NQFH@2323|unclassified Bacteria	2|Bacteria	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,Transket_pyr,Transketolase_C
HKD1_k127_6243101_9	204669.Acid345_4119	1.376e-77	274.0	COG1235@1|root,COG1235@2|Bacteria	2|Bacteria	P	May be involved in the transport of PQQ or its precursor to the periplasm	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_6243101_12	1118054.CAGW01000041_gene978	9.147e-43	176.0	COG1461@1|root,COG1461@2|Bacteria,1V4FH@1239|Firmicutes,4HEHV@91061|Bacilli,26Z1Z@186822|Paenibacillaceae	91061|Bacilli	S	Dak2	-	-	2.7.1.121	ko:K05879	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak2
HKD1_k127_6243101_4	1118054.CAGW01000041_gene977	5.748e-138	445.0	COG2376@1|root,COG2376@2|Bacteria,1TP92@1239|Firmicutes,4H9VS@91061|Bacilli,26V0N@186822|Paenibacillaceae	91061|Bacilli	G	Dihydroxyacetone kinase	-	-	2.7.1.121	ko:K05878	ko00561,ko01100,map00561,map01100	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000	-	-	-	Dak1
HKD1_k127_6254719_0	477974.Daud_1879	1.063e-179	572.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copA	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_6254719_2	395494.Galf_2722	1.011e-44	168.0	28WAT@1|root,2ZIB9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6254719_4	670307.HYPDE_36643	0.0009015	46.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria,3N727@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	STAS domain	MA20_05210	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD1_k127_6254719_1	1408303.JNJJ01000078_gene1182	4.155e-69	241.0	COG2020@1|root,COG2020@2|Bacteria,1UXZ3@1239|Firmicutes	1239|Firmicutes	O	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_6254719_3	443143.GM18_1063	1.136e-08	67.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,42MWM@68525|delta/epsilon subdivisions,2WK3H@28221|Deltaproteobacteria,43SBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD,SDH_sah
HKD1_k127_6258832_1	1123277.KB893172_gene951	2.237e-14	76.0	COG2133@1|root,COG3386@1|root,COG4386@1|root,COG2133@2|Bacteria,COG3386@2|Bacteria,COG4386@2|Bacteria,4PNUT@976|Bacteroidetes,47YJ9@768503|Cytophagia	976|Bacteroidetes	G	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD1_k127_6258832_0	1047013.AQSP01000122_gene2249	1.702e-97	338.0	28NDD@1|root,2ZBG6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_6258832_3	1108045.GORHZ_059_00010	5.855e-08	57.0	28NDD@1|root,2ZBG6@2|Bacteria,2H1UZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6258832_2	886293.Sinac_7345	4.107e-09	57.0	COG0642@1|root,COG0784@1|root,COG2202@1|root,COG2203@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IX8Z@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD1_k127_6266864_0	1304885.AUEY01000002_gene358	0.0	1278.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_6266864_5	204669.Acid345_4072	1.691e-124	419.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria,2JHZY@204432|Acidobacteriia	204432|Acidobacteriia	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_6266864_10	338966.Ppro_0413	5.972e-31	134.0	COG1226@1|root,32Y28@2|Bacteria,1MZYK@1224|Proteobacteria,42TR5@68525|delta/epsilon subdivisions,2WR6C@28221|Deltaproteobacteria,43UQM@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_6266864_4	1454004.AW11_02632	1.534e-125	411.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VMKT@28216|Betaproteobacteria	28216|Betaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_6266864_11	289377.HL41_03795	3.23e-28	117.0	COG2721@1|root,COG2721@2|Bacteria,2GI4H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	G	SAF domain	-	-	4.2.1.7	ko:K16849	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	SAF
HKD1_k127_6266864_1	573413.Spirs_1110	4.75e-164	524.0	COG2721@1|root,COG2721@2|Bacteria,2J6IB@203691|Spirochaetes	203691|Spirochaetes	G	D-galactarate dehydratase Altronate hydrolase	-	-	4.2.1.7	ko:K01685,ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
HKD1_k127_6266864_2	530564.Psta_0329	1.785e-156	506.0	COG0205@1|root,COG0205@2|Bacteria,2IX8A@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfk	-	2.7.1.11,2.7.1.90	ko:K00850,ko:K00895	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R00764,R02073,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_6266864_3	1396418.BATQ01000110_gene4803	1.443e-128	441.0	COG3264@1|root,COG3264@2|Bacteria,46T7X@74201|Verrucomicrobia,2IWP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_6266864_7	671143.DAMO_0895	1.076e-79	284.0	COG4784@1|root,COG4784@2|Bacteria,2NS4E@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD1_k127_6266864_8	671143.DAMO_0897	2.644e-73	256.0	COG0500@1|root,COG2226@2|Bacteria,2NPGE@2323|unclassified Bacteria	2|Bacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_6266864_6	671143.DAMO_0898	6.683e-93	314.0	COG0382@1|root,COG0382@2|Bacteria,2NP4W@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_6271072_0	596151.DesfrDRAFT_1785	1.739e-221	706.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,42M8M@68525|delta/epsilon subdivisions,2WJE2@28221|Deltaproteobacteria,2M80K@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	TIGRFAM Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_6271072_1	671143.DAMO_0860	8.233e-179	591.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	glnG	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0043565,GO:0044424,GO:0044444,GO:0044464,GO:0045892,GO:0045893,GO:0045934,GO:0045935,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:2000112,GO:2000113,GO:2001141	-	ko:K07712,ko:K07714	ko02020,map02020	M00497,M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6271072_3	671143.DAMO_0859	4.872e-110	374.0	COG3852@1|root,COG3852@2|Bacteria,2NS4D@2323|unclassified Bacteria	2|Bacteria	T	Signal transduction histidine kinase, nitrogen specific, NtrB	gnfL	-	2.7.13.3	ko:K07708,ko:K10942	ko02020,ko05111,map02020,map05111	M00497,M00515	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HKD1_k127_6271072_6	584708.Apau_0393	4.185e-65	233.0	COG0726@1|root,COG0726@2|Bacteria,3TAKV@508458|Synergistetes	508458|Synergistetes	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_6271072_4	555088.DealDRAFT_1940	3.489e-92	323.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,251A8@186801|Clostridia,42KNT@68298|Syntrophomonadaceae	186801|Clostridia	M	Male sterility protein	-	-	4.2.1.46,5.1.3.2	ko:K01710,ko:K01784	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R02984,R06513	RC00289,RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_6271072_5	880072.Desac_2831	1.436e-90	315.0	COG0223@1|root,COG0223@2|Bacteria,1MWH1@1224|Proteobacteria,42QSB@68525|delta/epsilon subdivisions,2WMWD@28221|Deltaproteobacteria,2MQSR@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Formyl transferase, C-terminal domain	arnG	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD1_k127_6271072_2	644282.Deba_2097	6.468e-115	383.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2WJV8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	arnC	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
HKD1_k127_6271072_7	1196323.ALKF01000183_gene5277	3.819e-42	159.0	COG1089@1|root,COG1089@2|Bacteria,1UJFF@1239|Firmicutes,4HF5Y@91061|Bacilli,275YJ@186822|Paenibacillaceae	91061|Bacilli	M	Polysaccharide biosynthesis protein	-	-	1.1.1.281	ko:K15856	ko00051,ko00520,map00051,map00520	-	R03397,R03399	RC00182	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_6271485_1	1121920.AUAU01000004_gene876	4.818e-172	550.0	COG2461@1|root,COG2461@2|Bacteria,3Y7BF@57723|Acidobacteria	57723|Acidobacteria	S	Family of unknown function (DUF438)	-	-	-	ko:K09155	-	-	-	-	ko00000	-	-	-	DUF438,Hemerythrin,PAS_10
HKD1_k127_6271485_18	1121920.AUAU01000004_gene877	8.728e-29	132.0	COG4309@1|root,COG4309@2|Bacteria,3Y8N7@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HKD1_k127_6271485_11	1052684.PPM_1323	4.102e-62	219.0	COG2318@1|root,COG2318@2|Bacteria,1V2BI@1239|Firmicutes,4HF8B@91061|Bacilli,26XPE@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the metal hydrolase YfiT family	yfiT	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_6271485_6	649638.Trad_2266	2.996e-103	348.0	COG1473@1|root,COG1473@2|Bacteria,1WM7N@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Peptidase family M20 M25 M40	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_6271485_2	1123392.AQWL01000002_gene1871	4.189e-140	471.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria	28216|Betaproteobacteria	PT	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD1_k127_6271485_21	266779.Meso_0729	0.0004156	47.0	2ETCE@1|root,33KWA@2|Bacteria,1NK3W@1224|Proteobacteria,2UM08@28211|Alphaproteobacteria,43MA7@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1344)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1344
HKD1_k127_6271485_16	215803.DB30_4444	9.233e-36	146.0	COG0265@1|root,COG0265@2|Bacteria,1Q2WX@1224|Proteobacteria,438JQ@68525|delta/epsilon subdivisions,2X3UD@28221|Deltaproteobacteria,2YX4M@29|Myxococcales	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_6271485_10	391623.TERMP_01605	8.895e-63	230.0	COG2055@1|root,arCOG04874@2157|Archaea,2XVBT@28890|Euryarchaeota,243UQ@183968|Thermococci	183968|Thermococci	C	L-malate dehydrogenase activity	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_6271485_17	1547437.LL06_19690	1.175e-34	137.0	COG0662@1|root,COG0662@2|Bacteria,1R1DU@1224|Proteobacteria,2TZ1H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_6271485_4	1304874.JAFY01000002_gene179	3.677e-111	376.0	COG3875@1|root,COG3875@2|Bacteria,3TARA@508458|Synergistetes	508458|Synergistetes	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_6271485_5	394.NGR_c25880	1.24e-104	357.0	COG2055@1|root,COG2055@2|Bacteria,1MWQY@1224|Proteobacteria,2TR37@28211|Alphaproteobacteria,4BBFQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	Malate/L-lactate dehydrogenase	comC	-	1.1.1.350	ko:K00073	ko00230,ko01120,map00230,map01120	-	R02935,R02936	RC00169	ko00000,ko00001,ko01000	-	-	-	Ldh_2
HKD1_k127_6271485_8	446470.Snas_1558	1.597e-88	304.0	COG1052@1|root,COG1052@2|Bacteria,2I3KH@201174|Actinobacteria	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_6271485_13	318996.AXAZ01000001_gene4836	2.5e-40	159.0	COG4126@1|root,COG4126@2|Bacteria,1MWVG@1224|Proteobacteria,2U0MW@28211|Alphaproteobacteria,3JS11@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Asp Glu hydantoin racemase	MA20_16560	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6271485_9	452863.Achl_0094	1.814e-77	271.0	COG3181@1|root,COG3181@2|Bacteria,2GJ89@201174|Actinobacteria,1W8WP@1268|Micrococcaceae	201174|Actinobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD1_k127_6271485_0	930171.Asphe3_00830	3.409e-182	583.0	COG3333@1|root,COG3333@2|Bacteria,2GJB2@201174|Actinobacteria,1W7VZ@1268|Micrococcaceae	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_6271485_19	1205680.CAKO01000037_gene1301	1.385e-21	100.0	2CQ1K@1|root,32SKA@2|Bacteria	2|Bacteria	S	membrane	MA20_15810	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_6271485_3	457429.ABJI02000033_gene5814	8.981e-137	443.0	COG0473@1|root,COG0473@2|Bacteria,2IAD3@201174|Actinobacteria	201174|Actinobacteria	CE	Isocitrate isopropylmalate dehydrogenase	leuB1	-	1.1.1.41,1.1.1.42,1.1.1.85	ko:K00030,ko:K00031,ko:K00052	ko00020,ko00290,ko00480,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00290,map00480,map00660,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00432,M00535,M00740	R00267,R00268,R00709,R00994,R01899,R04426,R10052	RC00001,RC00084,RC00114,RC00417,RC00626,RC02801,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_6271485_15	1343740.M271_24335	1.851e-38	159.0	COG1414@1|root,COG1414@2|Bacteria,2IK1Y@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	ko:K02624,ko:K13641	-	-	-	-	ko00000,ko03000	-	-	-	HTH_IclR,IclR
HKD1_k127_6271485_7	1340493.JNIF01000003_gene1816	4.435e-90	306.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	He_PIG,NHL,SGL
HKD1_k127_6271485_20	868131.MSWAN_0956	0.0002199	50.0	COG1145@1|root,COG1148@1|root,arCOG02180@2157|Archaea,arCOG02235@2157|Archaea,2Y2YF@28890|Euryarchaeota,23PAZ@183925|Methanobacteria	183925|Methanobacteria	C	PFAM 4Fe-4S	-	-	-	ko:K14108	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_10,Fer4_4
HKD1_k127_6271485_14	671143.DAMO_2378	3.372e-39	148.0	COG2151@1|root,COG2151@2|Bacteria,2NPUI@2323|unclassified Bacteria	2|Bacteria	S	Pfam:DUF59	paaD	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HKD1_k127_6271485_12	1278073.MYSTI_01205	1.44e-44	164.0	COG0822@1|root,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,4331F@68525|delta/epsilon subdivisions,2WXKR@28221|Deltaproteobacteria,2YY54@29|Myxococcales	28221|Deltaproteobacteria	C	SUF system FeS assembly protein	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_6283438_9	926569.ANT_26680	6.246e-21	104.0	COG0725@1|root,COG0725@2|Bacteria,2G6J6@200795|Chloroflexi	200795|Chloroflexi	P	Molybdenum ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	SBP_bac_11
HKD1_k127_6283438_5	706587.Desti_1467	3.027e-34	136.0	COG2164@1|root,COG2164@2|Bacteria,1N81P@1224|Proteobacteria,430JJ@68525|delta/epsilon subdivisions,2WVQQ@28221|Deltaproteobacteria,2MRZH@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
HKD1_k127_6283438_0	880072.Desac_2928	1.587e-290	928.0	COG1111@1|root,COG1205@1|root,COG1111@2|Bacteria,COG1205@2|Bacteria,1QU0I@1224|Proteobacteria,42M4R@68525|delta/epsilon subdivisions,2WK1V@28221|Deltaproteobacteria,2MQS2@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	yprA	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C,RNase_H_2
HKD1_k127_6283438_4	671143.DAMO_1446	8.486e-91	303.0	COG0500@1|root,COG2226@2|Bacteria,2NPUA@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	pmtA	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD1_k127_6283438_1	671143.DAMO_1611	2.399e-168	538.0	COG0303@1|root,COG0303@2|Bacteria,2NP4N@2323|unclassified Bacteria	2|Bacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HKD1_k127_6283438_6	671143.DAMO_1447	5.099e-33	134.0	COG1259@1|root,COG1259@2|Bacteria	2|Bacteria	K	PFAM Uncharacterised ACR, COG1259	yqdE	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,UVR
HKD1_k127_6283438_7	247490.KSU1_C0721	6.864e-27	126.0	COG0457@1|root,COG0457@2|Bacteria	247490.KSU1_C0721|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6283438_8	1382306.JNIM01000001_gene2847	1.072e-22	102.0	COG4911@1|root,COG4911@2|Bacteria,2G7A8@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HKD1_k127_6283438_3	1131269.AQVV01000028_gene28	4.375e-134	470.0	COG0421@1|root,COG0421@2|Bacteria	2|Bacteria	E	spermidine synthase activity	speE	GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HKD1_k127_6283438_10	1379270.AUXF01000004_gene3289	3.337e-18	89.0	COG2010@1|root,COG2010@2|Bacteria,1ZUYW@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_6283438_12	1454007.JAUG01000015_gene4191	0.0005583	51.0	2BI0D@1|root,32C51@2|Bacteria,4NTCG@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6283438_2	452637.Oter_3889	2.339e-136	439.0	COG2025@1|root,COG2025@2|Bacteria	2|Bacteria	C	fatty acid beta-oxidation using acyl-CoA dehydrogenase	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	Acyl-CoA_dh_1,ETF,ETF_alpha
HKD1_k127_6293776_1	1089551.KE386572_gene1393	1.01e-19	92.0	COG0683@1|root,COG0683@2|Bacteria,1N11P@1224|Proteobacteria,2TRQ4@28211|Alphaproteobacteria,4BT8Y@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6293776_2	1051646.VITU9109_06305	8.139e-13	75.0	COG0782@1|root,COG0782@2|Bacteria,1MZNI@1224|Proteobacteria,1SED1@1236|Gammaproteobacteria,1XXMF@135623|Vibrionales	135623|Vibrionales	K	COG0782 Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
HKD1_k127_6293776_3	519442.Huta_1189	1.728e-12	79.0	COG0477@1|root,arCOG00134@2157|Archaea,2XSYU@28890|Euryarchaeota,23U8Q@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6293776_0	1125863.JAFN01000001_gene888	5.753e-28	122.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,42TXX@68525|delta/epsilon subdivisions,2WQBC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,Peptidase_S15
HKD1_k127_6306331_10	1499967.BAYZ01000013_gene6470	1.113e-87	291.0	COG1840@1|root,COG1840@2|Bacteria	2|Bacteria	P	iron ion homeostasis	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6,SBP_bac_8
HKD1_k127_6306331_1	1499967.BAYZ01000013_gene6469	6.368e-247	775.0	COG1178@1|root,COG1178@2|Bacteria	2|Bacteria	P	thiamine transport	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_6306331_6	1499967.BAYZ01000013_gene6468	2.128e-126	421.0	COG3842@1|root,COG3842@2|Bacteria,2NQSQ@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	potA	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD1_k127_6306331_15	352165.HMPREF7215_2746	1.679e-53	203.0	COG0274@1|root,COG0274@2|Bacteria,3TAYF@508458|Synergistetes	508458|Synergistetes	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD1_k127_6306331_11	865861.AZSU01000006_gene1437	1.245e-84	301.0	COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,36GQQ@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase
HKD1_k127_6306331_19	1122919.KB905566_gene2750	1.992e-38	155.0	COG3970@1|root,COG3970@2|Bacteria,1U819@1239|Firmicutes,4HDEZ@91061|Bacilli,26V5A@186822|Paenibacillaceae	91061|Bacilli	S	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD1_k127_6306331_9	671143.DAMO_1210	4.272e-102	346.0	COG0012@1|root,COG0012@2|Bacteria,2NNNF@2323|unclassified Bacteria	2|Bacteria	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD1_k127_6306331_16	671143.DAMO_1212	5.756e-50	184.0	COG3359@1|root,COG3359@2|Bacteria,2NR6M@2323|unclassified Bacteria	2|Bacteria	L	RNase_H superfamily	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
HKD1_k127_6306331_7	760568.Desku_2656	2.522e-110	377.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,25ZY0@186807|Peptococcaceae	186801|Clostridia	J	MiaB-like tRNA modifying enzyme	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_6306331_13	1219084.AP014508_gene187	5.542e-80	277.0	COG0329@1|root,COG0329@2|Bacteria,2GC68@200918|Thermotogae	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_6306331_8	309801.trd_A0158	2.31e-109	373.0	COG0028@1|root,COG0028@2|Bacteria,2GBE1@200795|Chloroflexi,27Z26@189775|Thermomicrobia	189775|Thermomicrobia	EH	Thiamine pyrophosphate enzyme, central domain	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_6306331_5	671143.DAMO_1214	6.04e-137	441.0	COG0005@1|root,COG0005@2|Bacteria,2NNYQ@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004731,GO:0006082,GO:0006139,GO:0006144,GO:0006168,GO:0006520,GO:0006555,GO:0006725,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009112,GO:0009113,GO:0009987,GO:0016053,GO:0016740,GO:0016757,GO:0016763,GO:0017061,GO:0017144,GO:0018130,GO:0019438,GO:0019509,GO:0019752,GO:0034641,GO:0034654,GO:0042440,GO:0043094,GO:0043096,GO:0043101,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046083,GO:0046084,GO:0046112,GO:0046148,GO:0046394,GO:0046483,GO:0055086,GO:0071265,GO:0071267,GO:0071704,GO:0072521,GO:0072522,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2684	PNP_UDP_1
HKD1_k127_6306331_4	671143.DAMO_1215	1.31e-142	457.0	COG0524@1|root,COG0524@2|Bacteria,2NP1T@2323|unclassified Bacteria	2|Bacteria	G	pfkB family carbohydrate kinase	adoK	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004001,GO:0005488,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005975,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019200,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032552,GO:0032553,GO:0032554,GO:0032555,GO:0032559,GO:0032560,GO:0032561,GO:0032567,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046390,GO:0046483,GO:0046835,GO:0046872,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.15,2.7.1.20	ko:K00852,ko:K00856	ko00030,ko00230,ko01100,map00030,map00230,map01100	-	R00185,R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2683	PfkB
HKD1_k127_6306331_17	1499967.BAYZ01000139_gene144	6.339e-41	168.0	COG2199@1|root,COG3706@2|Bacteria,2NR9S@2323|unclassified Bacteria	2|Bacteria	T	Domain of unknown function (DUF4388)	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheX,HATPase_c,HisKA,Response_reg
HKD1_k127_6306331_18	1499967.BAYZ01000139_gene144	1.697e-40	166.0	COG2199@1|root,COG3706@2|Bacteria,2NR9S@2323|unclassified Bacteria	2|Bacteria	T	Domain of unknown function (DUF4388)	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	CheX,HATPase_c,HisKA,Response_reg
HKD1_k127_6306331_0	671143.DAMO_2342	0.0	1393.0	COG0178@1|root,COG0178@2|Bacteria,2NNT3@2323|unclassified Bacteria	2|Bacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032991,GO:0033554,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_6306331_23	1211114.ALIP01000120_gene1010	6.202e-06	54.0	COG2197@1|root,COG2197@2|Bacteria,1N5IE@1224|Proteobacteria,1SBR6@1236|Gammaproteobacteria,1X6EU@135614|Xanthomonadales	135614|Xanthomonadales	KT	Chemotaxis protein CheY	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_6306331_3	671143.DAMO_2838	1.5e-169	546.0	COG4191@1|root,COG4191@2|Bacteria,2NQ9P@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_6306331_2	671143.DAMO_2839	4.288e-181	579.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6306331_20	296591.Bpro_0109	3.361e-14	81.0	COG3115@1|root,COG3115@2|Bacteria,1QWGJ@1224|Proteobacteria,2WGZ3@28216|Betaproteobacteria,4AH94@80864|Comamonadaceae	28216|Betaproteobacteria	D	cell septum assembly	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6306331_14	1353531.AZNX01000005_gene3329	1.643e-56	212.0	COG0412@1|root,COG0412@2|Bacteria,1QW3K@1224|Proteobacteria,2TZDK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6306331_12	292459.STH2818	1.036e-81	288.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_6315169_2	477974.Daud_1982	3.429e-35	146.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,26187@186807|Peptococcaceae	186801|Clostridia	E	PFAM Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_6315169_1	330214.NIDE0543	2.356e-79	290.0	COG0642@1|root,COG2205@2|Bacteria	330214.NIDE0543|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6315169_0	671143.DAMO_1298	3.866e-157	510.0	COG2204@1|root,COG2204@2|Bacteria,2NP3X@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6322611_1	880073.Calab_2714	2.605e-148	490.0	COG0574@1|root,COG0784@1|root,COG0574@2|Bacteria,COG0784@2|Bacteria,2NQKM@2323|unclassified Bacteria	2|Bacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PPDK_N,Response_reg,SpoIIE
HKD1_k127_6322611_0	589865.DaAHT2_0126	1.051e-207	654.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,42NM8@68525|delta/epsilon subdivisions,2WIWB@28221|Deltaproteobacteria,2MIKK@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_6323109_26	416591.Tlet_0078	6.464e-36	144.0	COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,2GCYC@200918|Thermotogae	200918|Thermotogae	K	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD1_k127_6323109_6	1499967.BAYZ01000103_gene3717	1.644e-130	425.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	-	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6323109_21	1009370.ALO_15262	1.919e-72	252.0	COG3622@1|root,COG3622@2|Bacteria,1TRQV@1239|Firmicutes,4H44X@909932|Negativicutes	909932|Negativicutes	G	Belongs to the hyi family	-	-	5.3.1.22	ko:K01816	ko00630,ko01100,map00630,map01100	-	R01394	RC00511	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_6323109_2	1499967.BAYZ01000184_gene4609	2.882e-158	506.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_6323109_20	1056512.D515_02607	3.068e-79	283.0	COG2084@1|root,COG2084@2|Bacteria,1MUD0@1224|Proteobacteria,1RQXA@1236|Gammaproteobacteria,1XT03@135623|Vibrionales	135623|Vibrionales	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.411	ko:K08319	-	-	-	-	ko00000,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_6323109_18	1366046.HIMB11_01929	8.288e-88	299.0	COG1082@1|root,COG1082@2|Bacteria,1R5T9@1224|Proteobacteria,2U0P4@28211|Alphaproteobacteria,3ZI80@58840|unclassified Rhodobacteraceae	28211|Alphaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_6323109_9	1408422.JHYF01000002_gene2499	2.173e-107	359.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	dppB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_6323109_13	350688.Clos_1349	2.499e-96	336.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae	186801|Clostridia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_6323109_8	469616.FMAG_01307	3.727e-126	411.0	COG0444@1|root,COG0444@2|Bacteria,378P9@32066|Fusobacteria	32066|Fusobacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_6323109_7	1123075.AUDP01000029_gene2178	2.204e-128	418.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,3WGUX@541000|Ruminococcaceae	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_6323109_22	1304875.JAFZ01000001_gene1617	2.836e-72	263.0	COG0747@1|root,COG0747@2|Bacteria,3TAF1@508458|Synergistetes	508458|Synergistetes	E	family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_6323109_24	760568.Desku_1632	1.746e-55	206.0	COG1082@1|root,COG1082@2|Bacteria,1TRXP@1239|Firmicutes,24EWV@186801|Clostridia,262DG@186807|Peptococcaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	ko:K22233	ko00562,map00562	-	R11772	-	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_6323109_15	696281.Desru_2414	5.501e-90	307.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,24EUD@186801|Clostridia,267G2@186807|Peptococcaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.310,1.1.1.399,1.1.1.95	ko:K00058,ko:K16843	ko00260,ko00270,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513,R05693	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_6323109_29	573.JG24_04170	0.0001212	48.0	COG0673@1|root,COG0673@2|Bacteria,1MVVF@1224|Proteobacteria,1RMKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_6323109_11	1005048.CFU_0458	1.114e-104	359.0	COG0337@1|root,COG0703@1|root,COG0337@2|Bacteria,COG0703@2|Bacteria,1MUBK@1224|Proteobacteria,2VHXR@28216|Betaproteobacteria,4725Y@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD1_k127_6323109_14	338966.Ppro_2027	5.467e-96	326.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,42MW5@68525|delta/epsilon subdivisions,2WJKR@28221|Deltaproteobacteria,43TT5@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	2.7.1.71,4.2.3.4	ko:K01735,ko:K13829	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412,R03083	RC00002,RC00078,RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase,SKI
HKD1_k127_6323109_19	671143.DAMO_1400	2.246e-80	272.0	COG0231@1|root,COG0231@2|Bacteria,2NPID@2323|unclassified Bacteria	2|Bacteria	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD1_k127_6323109_27	648996.Theam_0221	1.57e-33	136.0	COG0511@1|root,COG0511@2|Bacteria,2G46B@200783|Aquificae	200783|Aquificae	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD1_k127_6323109_1	398767.Glov_1598	1.939e-180	574.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,43TSY@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Carbamoyl-phosphate synthetase large chain domain protein	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_6323109_23	671143.DAMO_1399	2.123e-57	216.0	COG0352@1|root,COG0352@2|Bacteria,2NPCU@2323|unclassified Bacteria	2|Bacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00788,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_6323109_5	926550.CLDAP_11320	2.374e-132	433.0	COG0683@1|root,COG0683@2|Bacteria,2G6Q3@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6323109_10	383372.Rcas_1893	1.981e-106	355.0	COG0559@1|root,COG0559@2|Bacteria,2G6FM@200795|Chloroflexi,375K9@32061|Chloroflexia	32061|Chloroflexia	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6323109_4	526227.Mesil_2494	1.912e-134	440.0	COG4177@1|root,COG4177@2|Bacteria,1WI2C@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	branched-chain amino acid transport system, permease component	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6323109_16	926550.CLDAP_29810	3.557e-89	301.0	COG0411@1|root,COG0411@2|Bacteria,2G5W6@200795|Chloroflexi	200795|Chloroflexi	E	PFAM ABC transporter related	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6323109_17	292459.STH1618	7.474e-89	300.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia	186801|Clostridia	E	Abc transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6323109_12	671143.DAMO_1394	1.536e-103	356.0	COG0683@1|root,COG0683@2|Bacteria,2NPSN@2323|unclassified Bacteria	2|Bacteria	E	Receptor family ligand binding region	livK	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006865,GO:0008150,GO:0015711,GO:0015803,GO:0015804,GO:0015818,GO:0015820,GO:0015829,GO:0015849,GO:0016597,GO:0030288,GO:0030313,GO:0031406,GO:0031975,GO:0036094,GO:0042597,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044464,GO:0046942,GO:0051179,GO:0051234,GO:0070728,GO:0071702,GO:0071705	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	iECNA114_1301.ECNA114_3569,iECSF_1327.ECSF_3279,iECs_1301.ECs4309,iEcSMS35_1347.EcSMS35_3743,iG2583_1286.G2583_4163,iSFxv_1172.SFxv_3794,iSSON_1240.SSON_3698,iS_1188.S4285,iUTI89_1310.UTI89_C3965,iYL1228.KPN_03820,iZ_1308.Z4834	Peripla_BP_6
HKD1_k127_6323109_25	671143.DAMO_1393	9.684e-47	175.0	COG0009@1|root,COG0009@2|Bacteria,2NPMH@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the SUA5 family	prmC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD1_k127_6323109_0	671143.DAMO_1392	1.408e-318	989.0	COG0317@1|root,COG0317@2|Bacteria,2NNM0@2323|unclassified Bacteria	2|Bacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_6323109_28	445335.CBN_2475	2.631e-17	85.0	COG0227@1|root,COG0227@2|Bacteria,1VEI2@1239|Firmicutes,24QNA@186801|Clostridia,36MTX@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD1_k127_6323109_3	644966.Tmar_0929	2.961e-142	473.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,3WCF1@538999|Clostridiales incertae sedis	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_6332624_3	1121861.KB899911_gene1175	1.336e-40	158.0	COG0747@1|root,COG0747@2|Bacteria,1MWBH@1224|Proteobacteria,2TTF4@28211|Alphaproteobacteria,2JRC2@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD1_k127_6332624_1	1121861.KB899920_gene2825	1.771e-120	398.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,2TSVB@28211|Alphaproteobacteria,2JQWH@204441|Rhodospirillales	204441|Rhodospirillales	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
HKD1_k127_6332624_2	391625.PPSIR1_15615	3.309e-112	371.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,42M16@68525|delta/epsilon subdivisions,2WM0V@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the carbamate kinase family	cpkA	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_6332624_0	671143.DAMO_0486	4.598e-194	610.0	COG0364@1|root,COG0364@2|Bacteria,2NNUR@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD1_k127_6332763_2	886293.Sinac_6642	2.482e-31	129.0	COG2055@1|root,COG2055@2|Bacteria,2IWXD@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the LDH2 MDH2 oxidoreductase family	-	-	-	ko:K13574	-	-	-	-	ko00000,ko01000	-	-	-	Ldh_2
HKD1_k127_6332763_0	243231.GSU1402	1.756e-121	397.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,42NC2@68525|delta/epsilon subdivisions,2WKA3@28221|Deltaproteobacteria,43UDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962,ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD1_k127_6332763_1	671143.DAMO_2856	2.842e-102	341.0	COG0587@1|root,COG0587@2|Bacteria,2NNVY@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase	dnaE	GO:0003674,GO:0003824,GO:0003887,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0032991,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044776,GO:0046483,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD1_k127_6339582_9	340099.Teth39_1677	1.563e-22	104.0	COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia,42F2E@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM D-galactarate dehydratase Altronate hydrolase domain protein	-	-	4.2.1.7,4.4.1.24	ko:K16846,ko:K16850	ko00040,ko00270,ko01100,map00040,map00270,map01100	M00631	R01540,R07633	RC00543,RC01785	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
HKD1_k127_6339582_8	1122919.KB905569_gene2928	1.372e-23	104.0	COG2721@1|root,COG2721@2|Bacteria,1VFEZ@1239|Firmicutes,4HRA1@91061|Bacilli,26YVN@186822|Paenibacillaceae	91061|Bacilli	G	SAF	-	-	4.2.1.7	ko:K16849	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	SAF
HKD1_k127_6339582_4	1267534.KB906755_gene4824	6.129e-69	239.0	2AY4N@1|root,31Q6J@2|Bacteria,3Y7H6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6339582_3	264732.Moth_2167	4.437e-103	348.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,42EZ0@68295|Thermoanaerobacterales	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD1_k127_6339582_7	671143.DAMO_2458	3.329e-42	156.0	COG0234@1|root,COG0234@2|Bacteria,2NPW2@2323|unclassified Bacteria	2|Bacteria	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0010033,GO:0016032,GO:0016465,GO:0019058,GO:0019068,GO:0032991,GO:0035966,GO:0042221,GO:0042802,GO:0043167,GO:0043169,GO:0044403,GO:0044419,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046872,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051704,GO:0061077,GO:0101031,GO:1990220	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_6339582_0	671143.DAMO_2457	1.815e-295	912.0	COG0459@1|root,COG0459@2|Bacteria,2NNM6@2323|unclassified Bacteria	2|Bacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0006950,GO:0008144,GO:0008150,GO:0009266,GO:0009314,GO:0009405,GO:0009408,GO:0009628,GO:0009966,GO:0009967,GO:0009986,GO:0009987,GO:0010646,GO:0010647,GO:0016032,GO:0016462,GO:0016465,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0018995,GO:0019058,GO:0019068,GO:0020003,GO:0022610,GO:0023051,GO:0023056,GO:0030430,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033643,GO:0033644,GO:0033646,GO:0033647,GO:0033648,GO:0033655,GO:0035639,GO:0035821,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043656,GO:0043657,GO:0043900,GO:0043903,GO:0044174,GO:0044175,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044218,GO:0044279,GO:0044403,GO:0044406,GO:0044419,GO:0044421,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044650,GO:0044764,GO:0046812,GO:0046872,GO:0048518,GO:0048522,GO:0048583,GO:0048584,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0051817,GO:0052047,GO:0052212,GO:0061077,GO:0065007,GO:0065010,GO:0097159,GO:0097367,GO:0101031,GO:1901222,GO:1901224,GO:1901265,GO:1901363,GO:1902531,GO:1902533,GO:1990220,GO:2000535	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_6339582_10	1232410.KI421424_gene1819	6.024e-21	96.0	2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,42VYW@68525|delta/epsilon subdivisions,2WR91@28221|Deltaproteobacteria,43VTK@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6339582_5	1128421.JAGA01000002_gene344	1.184e-55	202.0	COG0569@1|root,COG0569@2|Bacteria,2NPXT@2323|unclassified Bacteria	2|Bacteria	P	TrkA-N domain	ceoB	-	-	ko:K03499,ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6,2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_6339582_6	383372.Rcas_2661	7.504e-52	191.0	COG0569@1|root,COG0569@2|Bacteria,2G6J8@200795|Chloroflexi,377FQ@32061|Chloroflexia	32061|Chloroflexia	C	Putative NAD(P)-binding	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_6339582_1	383372.Rcas_0561	1.636e-195	626.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi,37597@32061|Chloroflexia	32061|Chloroflexia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_6339582_2	1121430.JMLG01000012_gene1995	2.948e-158	511.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,2609Z@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM Potassium uptake protein TrkH	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_6347256_2	795359.TOPB45_1258	4.327e-153	502.0	COG3604@1|root,COG3604@2|Bacteria,2GGRI@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	T	GAF domain	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
HKD1_k127_6347256_3	1449063.JMLS01000005_gene3209	6.051e-124	410.0	COG4134@1|root,COG4134@2|Bacteria,1TR3G@1239|Firmicutes,4HAW1@91061|Bacilli,26UDC@186822|Paenibacillaceae	91061|Bacilli	S	ABC transporter substrate-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD1_k127_6347256_10	1449063.JMLS01000005_gene3210	1.202e-61	226.0	COG1176@1|root,COG1176@2|Bacteria,1TR71@1239|Firmicutes,4HF3X@91061|Bacilli,26UD4@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter permease	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_6347256_5	1449063.JMLS01000005_gene3211	8.17e-89	301.0	COG1177@1|root,COG1177@2|Bacteria,1URBC@1239|Firmicutes,4HB65@91061|Bacilli,26QH1@186822|Paenibacillaceae	91061|Bacilli	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02053	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD1_k127_6347256_6	444157.Tneu_1009	8.502e-85	292.0	COG3839@1|root,arCOG00175@2157|Archaea,2XPVK@28889|Crenarchaeota	28889|Crenarchaeota	E	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,TOBE_2
HKD1_k127_6347256_16	1150474.JQJI01000020_gene1566	0.0001686	48.0	COG0395@1|root,COG0395@2|Bacteria,2GCRW@200918|Thermotogae	200918|Thermotogae	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6347256_11	1121430.JMLG01000002_gene1103	8.714e-53	194.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,2626X@186807|Peptococcaceae	186801|Clostridia	S	Belongs to the SfsA family	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
HKD1_k127_6347256_13	671143.DAMO_2924	5.898e-23	101.0	2CBGA@1|root,33A66@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6347256_8	469383.Cwoe_5826	6.424e-72	255.0	COG2047@1|root,COG2047@2|Bacteria,2I2H9@201174|Actinobacteria,4CP8R@84995|Rubrobacteria	84995|Rubrobacteria	S	PAC2 family	-	-	-	-	-	-	-	-	-	-	-	-	PAC2
HKD1_k127_6347256_9	96561.Dole_1179	4.242e-67	236.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,2MJ9P@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD1_k127_6347256_4	1191523.MROS_1726	4.716e-91	304.0	COG0176@1|root,COG0176@2|Bacteria	2|Bacteria	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0006002,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016830,GO:0016832,GO:0019637,GO:0044237,GO:0071704,GO:1901135	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_6347256_0	671143.DAMO_2213	1.605e-168	542.0	COG1078@1|root,COG1078@2|Bacteria,2NPZN@2323|unclassified Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_6347256_15	671143.DAMO_1874	4.029e-09	64.0	COG1622@1|root,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HKD1_k127_6347256_7	96561.Dole_3191	1.201e-81	290.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,42N0J@68525|delta/epsilon subdivisions,2WJFX@28221|Deltaproteobacteria,2MHNC@213118|Desulfobacterales	28221|Deltaproteobacteria	J	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD1_k127_6347256_12	706587.Desti_2731	1.161e-42	174.0	COG1466@1|root,COG1466@2|Bacteria,1Q2BW@1224|Proteobacteria,437YE@68525|delta/epsilon subdivisions,2X38A@28221|Deltaproteobacteria,2MSDN@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	dna polymerase III delta subunit	-	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	-
HKD1_k127_6347256_1	671143.DAMO_0704	1.514e-161	516.0	COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD1_k127_6347256_14	1121430.JMLG01000028_gene1458	4.68e-22	97.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia,262I5@186807|Peptococcaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD1_k127_6347770_1	671143.DAMO_0753	7.239e-58	203.0	COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria	2|Bacteria	O	Pup-ligase protein	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_6347770_2	290512.Paes_0556	1.043e-53	194.0	COG1528@1|root,COG1528@2|Bacteria,1FEMU@1090|Chlorobi	1090|Chlorobi	P	Iron-storage protein	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
HKD1_k127_6347770_0	247633.GP2143_05590	2.887e-160	517.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,1RPIT@1236|Gammaproteobacteria,1J68N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG4948 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	-	-	4.2.1.6	ko:K01684	ko00052,ko01100,ko01120,map00052,map01100,map01120	M00552	R03033	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_6354377_11	266117.Rxyl_3046	2.767e-54	199.0	COG1028@1|root,COG1028@2|Bacteria,2GYE3@201174|Actinobacteria	201174|Actinobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_6354377_12	472175.EL18_00339	8.126e-41	164.0	COG0673@1|root,COG0673@2|Bacteria,1MW74@1224|Proteobacteria,2TSFH@28211|Alphaproteobacteria,43NQS@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_6354377_10	545695.TREAZ_2400	4.864e-66	236.0	COG2084@1|root,COG2084@2|Bacteria,2J6T0@203691|Spirochaetes	203691|Spirochaetes	I	PFAM NAD binding domain of 6-phosphogluconate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_6354377_15	880072.Desac_1568	5.779e-14	75.0	COG3357@1|root,COG3357@2|Bacteria,1N7JG@1224|Proteobacteria,42VEP@68525|delta/epsilon subdivisions,2WRD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	transcriptional regulator containing an HTH domain fused to a Zn-ribbon	-	-	-	ko:K07743	-	-	-	-	ko00000	-	-	-	HTH_5
HKD1_k127_6354377_8	1033743.CAES01000015_gene2274	1.392e-83	291.0	COG1840@1|root,COG1840@2|Bacteria,1TQC3@1239|Firmicutes,4HCVR@91061|Bacilli,274TB@186822|Paenibacillaceae	91061|Bacilli	P	Iron ABC transporter substrate-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD1_k127_6354377_5	335543.Sfum_3496	1.72e-105	353.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42MUK@68525|delta/epsilon subdivisions,2X5CN@28221|Deltaproteobacteria,2MRN0@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.30	ko:K02010	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10	-	-	ABC_tran,TOBE_2
HKD1_k127_6354377_3	1007103.AFHW01000011_gene6034	4.886e-153	501.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,274ZY@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_6354377_9	485913.Krac_2136	3.586e-76	266.0	COG1506@1|root,COG1506@2|Bacteria,2G94D@200795|Chloroflexi	200795|Chloroflexi	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6354377_13	880072.Desac_2224	5.447e-32	142.0	COG1011@1|root,COG1011@2|Bacteria,1Q6A1@1224|Proteobacteria,43F2Y@68525|delta/epsilon subdivisions,2X36J@28221|Deltaproteobacteria,2MS5Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.10	ko:K20866	ko00010,ko01120,map00010,map01120	-	R00947	RC00078	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_6354377_17	1449050.JNLE01000003_gene1247	0.000123	48.0	COG0524@1|root,COG0524@2|Bacteria,1V123@1239|Firmicutes,24DMU@186801|Clostridia,36I14@31979|Clostridiaceae	186801|Clostridia	G	Kinase, PfkB family	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD1_k127_6354377_7	589924.Ferp_0226	2.242e-95	324.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota,245XE@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_6354377_0	290397.Adeh_3396	0.0	1106.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2YUFQ@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_6354377_16	935565.JAEM01000059_gene2866	1.942e-10	68.0	COG2176@1|root,COG5002@1|root,COG2176@2|Bacteria,COG5002@2|Bacteria,1QUVW@1224|Proteobacteria,2TSZS@28211|Alphaproteobacteria,2PWG8@265|Paracoccus	28211|Alphaproteobacteria	LT	EXOIII	polC	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T,VRR_NUC
HKD1_k127_6354377_6	309801.trd_1116	3.611e-96	332.0	COG2905@1|root,COG2905@2|Bacteria,2G600@200795|Chloroflexi	200795|Chloroflexi	T	CBS domain containing protein	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS,DUF294,DUF294_C,cNMP_binding
HKD1_k127_6354377_2	378806.STAUR_1231	4.083e-186	593.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,42QW3@68525|delta/epsilon subdivisions,2WNT9@28221|Deltaproteobacteria,2YZ0Y@29|Myxococcales	28221|Deltaproteobacteria	P	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_6354377_4	234267.Acid_5794	1.169e-128	437.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria	57723|Acidobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_6354377_1	880072.Desac_2385	8.39e-190	607.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Hydrophobe amphiphile Efflux-1 (HAE1) family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_6355832_11	1399774.JDWH01000007_gene1699	1.175e-23	116.0	28ISW@1|root,2Z8RZ@2|Bacteria,1R4AR@1224|Proteobacteria,1RMPA@1236|Gammaproteobacteria,3X24W@547|Enterobacter	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HKD1_k127_6355832_1	671143.DAMO_3141	6.965e-156	499.0	COG0686@1|root,COG0686@2|Bacteria,2NP43@2323|unclassified Bacteria	2|Bacteria	E	Alanine dehydrogenase/PNT, C-terminal domain	ald	GO:0000286,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006522,GO:0006524,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009078,GO:0009080,GO:0009653,GO:0009987,GO:0016054,GO:0016491,GO:0016638,GO:0019752,GO:0030154,GO:0030435,GO:0032502,GO:0043436,GO:0043934,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048646,GO:0048856,GO:0048869,GO:0055114,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_1099	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_6355832_4	671143.DAMO_2426	3.413e-127	412.0	COG0171@1|root,COG0171@2|Bacteria,2NNW4@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016874,GO:0016879,GO:0016880,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD1_k127_6355832_7	671143.DAMO_2425	2.627e-107	355.0	COG0388@1|root,COG0388@2|Bacteria,2NQD8@2323|unclassified Bacteria	2|Bacteria	S	Carbon-nitrogen hydrolase	-	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
HKD1_k127_6355832_5	1499967.BAYZ01000104_gene3692	1.42e-118	394.0	COG0738@1|root,COG0738@2|Bacteria	2|Bacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6355832_6	686340.Metal_0653	5.583e-110	361.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,1RX1E@1236|Gammaproteobacteria,1XG15@135618|Methylococcales	135618|Methylococcales	IQ	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6355832_9	251229.Chro_1508	2.69e-63	225.0	COG0454@1|root,COG0454@2|Bacteria,1GQF0@1117|Cyanobacteria	1117|Cyanobacteria	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_6355832_10	497964.CfE428DRAFT_1693	4.41e-28	127.0	COG0859@1|root,COG0859@2|Bacteria,46SZK@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_6355832_2	523791.Kkor_1648	9.626e-138	446.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,1XPP9@135619|Oceanospirillales	135619|Oceanospirillales	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_6355832_0	671143.DAMO_2423	2.548e-211	683.0	COG1198@1|root,COG1198@2|Bacteria,2NNQ3@2323|unclassified Bacteria	2|Bacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_6355832_8	671143.DAMO_2419	3.664e-100	331.0	COG1573@1|root,COG1573@2|Bacteria,2NP99@2323|unclassified Bacteria	2|Bacteria	L	Uracil DNA glycosylase superfamily	dpo	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_6355832_3	671143.DAMO_2418	2.422e-128	421.0	COG0452@1|root,COG0452@2|Bacteria,2NNX9@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_635714_1	1121939.L861_17285	1.395e-37	143.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD1_k127_635714_2	1121939.L861_17285	6.406e-30	124.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,1RRDD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD1_k127_635714_0	879212.DespoDRAFT_03175	3.005e-137	452.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,42P4F@68525|delta/epsilon subdivisions,2WJVT@28221|Deltaproteobacteria,2MNQI@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Pfam:KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HKD1_k127_635714_3	114615.BRADO3983	1.768e-13	75.0	COG4251@1|root,COG4251@2|Bacteria,1N5VP@1224|Proteobacteria,2UNI3@28211|Alphaproteobacteria,3K53Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Function of strongly homologous gene	-	-	-	ko:K08481	-	-	-	-	ko00000	-	-	-	KaiB
HKD1_k127_6367332_2	189753.AXAS01000041_gene2534	1.864e-46	172.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_6367332_1	1304877.KI519400_gene480	3.008e-69	250.0	COG0346@1|root,COG0346@2|Bacteria,1P5FR@1224|Proteobacteria,2TVCC@28211|Alphaproteobacteria,3JSK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	1.13.11.25	ko:K16049	ko00984,ko01100,ko01120,ko01220,map00984,map01100,map01120,map01220	-	R04597	RC01610	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD1_k127_6367332_0	113395.AXAI01000002_gene5148	7.445e-118	392.0	COG1653@1|root,COG1653@2|Bacteria,1R5NT@1224|Proteobacteria,2TTRQ@28211|Alphaproteobacteria,3JSBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_6372217_1	1123257.AUFV01000013_gene2764	2.339e-87	292.0	COG2801@1|root,COG2801@2|Bacteria,1R6QN@1224|Proteobacteria,1S7GS@1236|Gammaproteobacteria,1X49T@135614|Xanthomonadales	135614|Xanthomonadales	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	rve
HKD1_k127_6372217_3	269799.Gmet_1011	8.123e-34	132.0	COG2329@1|root,COG2329@2|Bacteria,1P7F5@1224|Proteobacteria,432G7@68525|delta/epsilon subdivisions,2WXUX@28221|Deltaproteobacteria,43VXE@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_6372217_5	443143.GM18_1107	1.35e-13	73.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD1_k127_6372217_0	404589.Anae109_2758	2.182e-170	554.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	-	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD1_k127_6372217_2	404380.Gbem_1249	4.989e-53	196.0	COG2010@1|root,COG2010@2|Bacteria,1RDSI@1224|Proteobacteria,42WEW@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	cytochrome c	norC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C
HKD1_k127_6381867_0	671143.DAMO_2259	3.31e-289	897.0	COG0481@1|root,COG0481@2|Bacteria,2NNXG@2323|unclassified Bacteria	2|Bacteria	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0006950,GO:0006970,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009268,GO:0009409,GO:0009628,GO:0009651,GO:0009987,GO:0010467,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034641,GO:0034645,GO:0035639,GO:0036094,GO:0042802,GO:0043021,GO:0043023,GO:0043024,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0050896,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_6381867_1	671143.DAMO_2260	3.214e-94	321.0	COG0142@1|root,COG0142@2|Bacteria,2NP7G@2323|unclassified Bacteria	2|Bacteria	H	Belongs to the FPP GGPP synthase family	ispB	GO:0003674,GO:0003824,GO:0004659,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006629,GO:0006720,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009108,GO:0009987,GO:0016093,GO:0016094,GO:0016740,GO:0016765,GO:0042180,GO:0042181,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046165,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901615,GO:1901617,GO:1901661,GO:1901663	2.5.1.30,2.5.1.90	ko:K00805,ko:K02523	ko00900,ko01110,map00900,map01110	-	R09247,R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	iYL1228.KPN_03597,ic_1306.c3945	polyprenyl_synt
HKD1_k127_6382700_2	1047013.AQSP01000109_gene2428	2.035e-12	70.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_3,Phage_int_SAM_5,Phage_integrase
HKD1_k127_6382700_0	1329516.JPST01000005_gene1351	1.078e-95	319.0	COG3253@1|root,COG3253@2|Bacteria,1VZPB@1239|Firmicutes,4HZ7E@91061|Bacilli,27B36@186824|Thermoactinomycetaceae	91061|Bacilli	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD1_k127_6382700_1	330214.NIDE2765	3.003e-14	81.0	COG4235@1|root,COG4235@2|Bacteria	2|Bacteria	O	cytochrome complex assembly	cycH	-	3.4.21.105	ko:K02200,ko:K04018,ko:K19225,ko:K20543,ko:K21007	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.55.3	-	-	TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_6382700_3	556269.ACDQ01000016_gene451	1.824e-10	64.0	COG1942@1|root,COG1942@2|Bacteria,1NG98@1224|Proteobacteria,2WFVM@28216|Betaproteobacteria,47902@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_6382700_4	671143.DAMO_3140	2.075e-10	66.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.163,2.1.1.201	ko:K03183,ko:K15256	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD1_k127_6401007_13	266117.Rxyl_0920	3.304e-69	239.0	COG0674@1|root,COG0674@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_6401007_10	266117.Rxyl_0919	7.239e-100	339.0	COG1144@1|root,COG1144@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	porD	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K00172,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,Fer4_21,POR
HKD1_k127_6401007_19	573063.Metin_0665	5.795e-17	92.0	COG1082@1|root,arCOG01899@2157|Archaea,2XWSW@28890|Euryarchaeota,23QVE@183939|Methanococci	183939|Methanococci	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_6401007_14	589865.DaAHT2_0263	4.176e-67	248.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,42QM3@68525|delta/epsilon subdivisions,2WKI2@28221|Deltaproteobacteria,2MI4S@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD1_k127_6401007_6	1303518.CCALI_01551	4.071e-133	447.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	kinB	-	2.7.13.3	ko:K11383	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,KinB_sensor,PAS,PAS_4
HKD1_k127_6401007_15	1303518.CCALI_01550	5.923e-40	158.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Methyltransf_23,Response_reg
HKD1_k127_6401007_16	1121957.ATVL01000011_gene3813	9.462e-30	125.0	COG1502@1|root,COG1502@2|Bacteria,4NRMR@976|Bacteroidetes,47QHV@768503|Cytophagia	976|Bacteroidetes	I	PLD-like domain	-	-	3.1.4.4	ko:K17717	ko00564,ko00565,ko01100,ko01110,map00564,map00565,map01100,map01110	-	R01310,R02051,R07385	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD1_k127_6401007_8	1125863.JAFN01000001_gene2805	5.454e-118	394.0	COG0569@1|root,COG0569@2|Bacteria,1MW8R@1224|Proteobacteria,42NWZ@68525|delta/epsilon subdivisions,2WJU7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM TrkA-N domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_6401007_4	580340.Tlie_1429	2.746e-157	509.0	COG0168@1|root,COG0168@2|Bacteria,3T9WI@508458|Synergistetes	508458|Synergistetes	P	Potassium uptake protein, TrkH family	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_6401007_5	1476583.DEIPH_ctg030orf0023	6.333e-138	469.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1WIY2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	CP	NADH ubiquinone oxidoreductase subunit 5 (chain L) Multisubunit Na H antiporter, MnhA subunit	-	-	-	ko:K05559,ko:K05565	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	DUF4040,Proton_antipo_M,Proton_antipo_N
HKD1_k127_6401007_17	322710.Avin_19530	2.915e-23	112.0	COG1009@1|root,COG2111@1|root,COG1009@2|Bacteria,COG2111@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CP	NADH ubiquinone oxidoreductase subunit 5 (Chain L) Multisubunit Na H antiporter, MnhA subunit	phaA	-	1.6.5.3	ko:K00341,ko:K05559	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.63.1,3.D.1	-	-	DUF4040,MnhB,Proton_antipo_M,Proton_antipo_N
HKD1_k127_6401007_20	1500259.JQLD01000005_gene275	1.156e-15	84.0	COG1006@1|root,COG1006@2|Bacteria,1NF6Q@1224|Proteobacteria,2UA2A@28211|Alphaproteobacteria,4BEJ7@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Na H antiporter	mnhC	-	-	ko:K05567	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Oxidored_q2
HKD1_k127_6401007_7	272558.10173932	4.615e-125	418.0	COG0651@1|root,COG0651@2|Bacteria,1TRAT@1239|Firmicutes,4HA10@91061|Bacilli,1ZB2A@1386|Bacillus	91061|Bacilli	CP	Subunit D of antiporter complex involved in resistance to high concentrations of Na , K , Li and or alkali	mrpD	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD1_k127_6401007_21	290315.Clim_0981	1.211e-13	85.0	COG1863@1|root,COG1863@2|Bacteria	2|Bacteria	P	multisubunit Na H antiporter MnhE subunit	mrpE	-	-	ko:K05569	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	MNHE
HKD1_k127_6401007_22	202956.BBNL01000002_gene1195	3.843e-12	70.0	COG2212@1|root,COG2212@2|Bacteria,1N8WJ@1224|Proteobacteria,1S8ZM@1236|Gammaproteobacteria,3NP1Y@468|Moraxellaceae	1236|Gammaproteobacteria	P	Multiple resistance and pH regulation protein F (MrpF / PhaF)	phaF	-	-	ko:K05563	-	-	-	-	ko00000,ko02000	2.A.63.1	-	-	MrpF_PhaF
HKD1_k127_6401007_18	1347086.CCBA010000003_gene3833	4.848e-21	99.0	COG1320@1|root,COG1320@2|Bacteria,1VABT@1239|Firmicutes,4HKX5@91061|Bacilli,1ZHVK@1386|Bacillus	91061|Bacilli	P	COG1320 Multisubunit Na H antiporter, MnhG subunit	-	-	-	ko:K05571	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	PhaG_MnhG_YufB
HKD1_k127_6401007_3	765420.OSCT_0234	6.958e-199	637.0	COG0531@1|root,COG0531@2|Bacteria,2G5ZF@200795|Chloroflexi,37597@32061|Chloroflexia	32061|Chloroflexia	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_6401007_9	671143.DAMO_0415	5.603e-110	364.0	COG0745@1|root,COG0745@2|Bacteria,2NQWD@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6401007_0	671143.DAMO_0414	0.0	1180.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_6401007_23	356851.JOAN01000001_gene3527	6.088e-11	72.0	COG0642@1|root,COG2205@2|Bacteria,2GJKC@201174|Actinobacteria,4DBA8@85008|Micromonosporales	201174|Actinobacteria	T	Domain of unknown function (DUF4118)	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_6401007_11	671143.DAMO_0413	1.155e-74	255.0	COG2156@1|root,COG2156@2|Bacteria,2NPIZ@2323|unclassified Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031004,GO:0031224,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044425,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iEcE24377_1341.EcE24377A_0722,ic_1306.c0781	KdpC
HKD1_k127_6401007_1	1254432.SCE1572_09215	0.0	1008.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,2YWXY@29|Myxococcales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
HKD1_k127_6401007_2	671143.DAMO_0410	1.001e-281	877.0	COG2060@1|root,COG2060@2|Bacteria,2NP13@2323|unclassified Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717	KdpA
HKD1_k127_6401007_12	1121468.AUBR01000015_gene2267	3.181e-70	242.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,42F8Y@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM TrkA-N domain protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_6401280_1	1121918.ARWE01000001_gene3108	1.041e-27	119.0	COG0580@1|root,COG0580@2|Bacteria,1MZ47@1224|Proteobacteria	1224|Proteobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_6401280_0	1121875.KB907549_gene1996	2.014e-172	547.0	COG1063@1|root,COG1063@2|Bacteria,4P3W3@976|Bacteroidetes	976|Bacteroidetes	E	Glucose dehydrogenase C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HKD1_k127_6401280_2	1172180.KB911782_gene4084	4.305e-25	106.0	COG0366@1|root,COG0366@2|Bacteria,2GN52@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase catalytic	amyA	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD1_k127_6432580_0	1408418.JNJH01000015_gene3259	1.212e-92	315.0	COG3464@1|root,COG3464@2|Bacteria,1QW5Z@1224|Proteobacteria,2U3N2@28211|Alphaproteobacteria,2JSJV@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66
HKD1_k127_6432580_1	91464.S7335_1012	1.212e-41	169.0	COG3464@1|root,COG3464@2|Bacteria,1G377@1117|Cyanobacteria,1H3U4@1129|Synechococcus	1117|Cyanobacteria	L	L COG3436 Transposase and inactivated derivatives	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_6432580_2	1121116.KB894787_gene87	0.0008326	44.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2VHFJ@28216|Betaproteobacteria,4ACTE@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
HKD1_k127_6441833_1	211586.SO_2874	2.602e-49	189.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,2QEEF@267890|Shewanellaceae	1236|Gammaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD1_k127_6441833_0	1121106.JQKB01000102_gene1932	4.991e-82	278.0	28JEU@1|root,2Z98W@2|Bacteria,1NQMD@1224|Proteobacteria,2UQA2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	MULE transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	MULE
HKD1_k127_6441833_2	1217720.ALOX01000142_gene3559	3.701e-49	183.0	2ED3F@1|root,3370B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6441833_3	886293.Sinac_5771	1.238e-28	117.0	COG2963@1|root,COG2963@2|Bacteria,2J1HR@203682|Planctomycetes	203682|Planctomycetes	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD1_k127_6459633_0	1125863.JAFN01000001_gene2073	2.635e-99	339.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,42MNF@68525|delta/epsilon subdivisions,2WIYR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Peptidase M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_6480005_16	584708.Apau_0757	3.774e-24	103.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,3T9V0@508458|Synergistetes	508458|Synergistetes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_6480005_18	880073.Calab_1228	3.827e-20	91.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD1_k127_6480005_13	880073.Calab_1228	1.108e-44	166.0	COG3634@1|root,COG3634@2|Bacteria,2NPR2@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD1_k127_6480005_1	706587.Desti_4134	4.566e-181	580.0	COG3303@1|root,COG3303@2|Bacteria,1P8CP@1224|Proteobacteria,42MXS@68525|delta/epsilon subdivisions,2WKEK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Seven times multi-haem cytochrome CxxCH	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Multi-haem_cyto
HKD1_k127_6480005_8	264732.Moth_1589	4.469e-71	252.0	COG0451@1|root,COG0451@2|Bacteria,1V2FY@1239|Firmicutes,24M1N@186801|Clostridia	186801|Clostridia	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_6480005_9	335543.Sfum_3512	4.494e-60	216.0	COG0861@1|root,COG0861@2|Bacteria,1QZU6@1224|Proteobacteria,42S1Q@68525|delta/epsilon subdivisions,2WNNS@28221|Deltaproteobacteria,2MQEU@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM Integral membrane protein TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD1_k127_6480005_2	543913.D521_0540	2.885e-180	577.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2VHKU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_6480005_17	1157708.KB907457_gene2669	4.484e-21	100.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria,4AERJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_6480005_5	1000565.METUNv1_02039	7.757e-116	385.0	COG3181@1|root,COG3181@2|Bacteria,1MXEX@1224|Proteobacteria,2VK0Q@28216|Betaproteobacteria,2KXJ0@206389|Rhodocyclales	206389|Rhodocyclales	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD1_k127_6480005_3	264732.Moth_1591	1.622e-147	475.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,42HZF@68295|Thermoanaerobacterales	186801|Clostridia	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_6480005_4	264732.Moth_1592	3.645e-147	477.0	COG0674@1|root,COG0674@2|Bacteria,1VS48@1239|Firmicutes,25E5U@186801|Clostridia,42HVU@68295|Thermoanaerobacterales	186801|Clostridia	C	Pyruvate:ferredoxin oxidoreductase core domain II	porA	GO:0003674,GO:0003824,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00169,ko:K19070	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_6480005_15	264732.Moth_1593	1.385e-25	109.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24H1B@186801|Clostridia,42HV5@68295|Thermoanaerobacterales	186801|Clostridia	C	COGs COG1144 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase delta subunit	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
HKD1_k127_6480005_10	264732.Moth_1593	3.387e-57	205.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,1VAAJ@1239|Firmicutes,24H1B@186801|Clostridia,42HV5@68295|Thermoanaerobacterales	186801|Clostridia	C	COGs COG1144 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductase delta subunit	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00171,ko:K19072	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,POR
HKD1_k127_6480005_0	401526.TcarDRAFT_1852	3.222e-234	747.0	COG1222@1|root,COG1222@2|Bacteria,1TRKW@1239|Firmicutes,4H748@909932|Negativicutes	909932|Negativicutes	O	AAA family ATPase, CDC48 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_6480005_14	555088.DealDRAFT_1846	6.635e-40	160.0	COG2186@1|root,COG2186@2|Bacteria	2|Bacteria	K	Transcriptional regulator	yvfI	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD1_k127_6480005_19	1121035.AUCH01000005_gene34	4.751e-11	73.0	2E2CU@1|root,32XHR@2|Bacteria,1N43P@1224|Proteobacteria,2VVI7@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6480005_6	1286093.C266_13249	6.075e-108	365.0	COG2223@1|root,COG2223@2|Bacteria,1MVFQ@1224|Proteobacteria,2WGVG@28216|Betaproteobacteria,1KIFQ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HKD1_k127_6480005_12	768704.Desmer_1773	1.985e-50	188.0	COG1028@1|root,COG1028@2|Bacteria,1V05R@1239|Firmicutes,249EC@186801|Clostridia,2602W@186807|Peptococcaceae	186801|Clostridia	IQ	PFAM short chain dehydrogenase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6480005_20	434131.NRI_0292	0.0007322	46.0	COG0316@1|root,COG0316@2|Bacteria	2|Bacteria	S	protein maturation	iscA	GO:0003674,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008198,GO:0009058,GO:0009987,GO:0010467,GO:0016043,GO:0016226,GO:0018130,GO:0019438,GO:0019538,GO:0022607,GO:0031163,GO:0031974,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046148,GO:0046483,GO:0046872,GO:0046914,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051537,GO:0051540,GO:0051604,GO:0070013,GO:0071704,GO:0071840,GO:0097428,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	-	ko:K13628,ko:K15724,ko:K22063	-	-	-	-	ko00000,ko03016,ko03029	-	-	-	Fe-S_biosyn
HKD1_k127_6480005_11	671143.DAMO_0819	3.154e-54	216.0	COG3637@1|root,COG3637@2|Bacteria,2NQC8@2323|unclassified Bacteria	2|Bacteria	M	Putative outer membrane beta-barrel porin, MtrB/PioB	-	-	-	-	-	-	-	-	-	-	-	-	Ail_Lom,MtrB_PioB
HKD1_k127_6480005_7	671143.DAMO_0818	5.712e-79	276.0	COG3005@1|root,COG3005@2|Bacteria,2NQ90@2323|unclassified Bacteria	2|Bacteria	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	ko:K08354	ko00920,ko01120,map00920,map01120	-	R10149	RC02823	ko00000,ko00001,ko02000	5.A.3.5	-	-	Cytochrome_C554,Cytochrome_C7,Ni_hydr_CYTB,Paired_CXXCH_1
HKD1_k127_6480563_1	1366050.N234_34040	9.528e-42	160.0	COG4648@1|root,COG4648@2|Bacteria,1N0PK@1224|Proteobacteria,2VUK9@28216|Betaproteobacteria,1K0CA@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6480563_0	243231.GSU0247	3.801e-236	740.0	COG1032@1|root,COG1032@2|Bacteria,1RCWX@1224|Proteobacteria,43AIJ@68525|delta/epsilon subdivisions,2X5YS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_6480563_2	247490.KSU1_C1386	2.366e-06	53.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	-	-	2.3.1.241,2.3.1.265	ko:K02517,ko:K20543,ko:K22311	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	1.B.55.3	-	-	Lip_A_acyltrans,TPR_19
HKD1_k127_649441_0	1121448.DGI_2643	3.074e-149	484.0	COG1861@1|root,COG1861@2|Bacteria,1QU5J@1224|Proteobacteria,43EAS@68525|delta/epsilon subdivisions,2X7TI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD1_k127_6501087_13	671143.DAMO_1836	1.963e-67	236.0	COG0860@1|root,COG0860@2|Bacteria,2NPCZ@2323|unclassified Bacteria	2|Bacteria	M	Ami_3	amiA	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HKD1_k127_6501087_29	316067.Geob_1364	7.365e-08	63.0	COG5401@1|root,COG5401@2|Bacteria,1NA0G@1224|Proteobacteria,42V1V@68525|delta/epsilon subdivisions,2WRCV@28221|Deltaproteobacteria,43V6T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HKD1_k127_6501087_5	671143.DAMO_1834	8.88e-99	331.0	COG0689@1|root,COG0689@2|Bacteria,2NP3K@2323|unclassified Bacteria	2|Bacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0006139,GO:0006364,GO:0006396,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016075,GO:0016787,GO:0016788,GO:0019439,GO:0022613,GO:0031123,GO:0031125,GO:0034470,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0042254,GO:0043170,GO:0043628,GO:0044085,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360,GO:1901361,GO:1901575	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_6501087_16	926550.CLDAP_08330	3.507e-60	218.0	COG0127@1|root,COG0127@2|Bacteria,2G6GK@200795|Chloroflexi	200795|Chloroflexi	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_6501087_30	1121355.KB903379_gene745	2.415e-07	57.0	COG0544@1|root,COG0544@2|Bacteria,2GJIG@201174|Actinobacteria,22JV9@1653|Corynebacteriaceae	201174|Actinobacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006950,GO:0007154,GO:0008150,GO:0009267,GO:0009605,GO:0009987,GO:0009991,GO:0016020,GO:0030312,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0042221,GO:0042594,GO:0044424,GO:0044444,GO:0044464,GO:0046677,GO:0050896,GO:0051716,GO:0071496,GO:0071944	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_6501087_33	1111728.ATYS01000016_gene4632	0.0003638	46.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6501087_4	671143.DAMO_2178	1.033e-101	347.0	COG0544@1|root,COG0544@2|Bacteria,2NPBN@2323|unclassified Bacteria	2|Bacteria	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_6501087_3	671143.DAMO_2179	5.916e-104	347.0	COG0740@1|root,COG0740@2|Bacteria,2NNPA@2323|unclassified Bacteria	2|Bacteria	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0008150,GO:0016020,GO:0030312,GO:0040007,GO:0044424,GO:0044444,GO:0044464,GO:0071944	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_6501087_0	671143.DAMO_2181	1.506e-230	717.0	COG1219@1|root,COG1219@2|Bacteria,2NNN2@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD1_k127_6501087_15	671143.DAMO_2182	6.626e-62	225.0	COG4105@1|root,COG4105@2|Bacteria,2NPZ3@2323|unclassified Bacteria	2|Bacteria	S	Outer membrane lipoprotein	bamD	-	-	ko:K05807,ko:K08309	-	-	-	-	ko00000,ko01000,ko01011,ko02000	1.B.33.1	GH23	-	YfiO
HKD1_k127_6501087_14	671143.DAMO_2183	2.621e-63	238.0	COG0030@1|root,COG0030@2|Bacteria,2NPDT@2323|unclassified Bacteria	2|Bacteria	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_6501087_1	1220534.B655_1300	1.154e-142	463.0	COG1488@1|root,arCOG01481@2157|Archaea,2XU8Y@28890|Euryarchaeota	28890|Euryarchaeota	H	Nicotinic acid phosphoribosyltransferase	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_6501087_11	671143.DAMO_2184	6.952e-71	254.0	COG0611@1|root,COG0611@2|Bacteria,2NP8J@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009030,GO:0009058,GO:0009108,GO:0009110,GO:0009228,GO:0009229,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0035639,GO:0036094,GO:0040007,GO:0042357,GO:0042364,GO:0042723,GO:0042724,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0051186,GO:0051188,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.16	ko:K00946,ko:K07123	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv2977c,iSFV_1184.SFV_0382,iYO844.BSU05900	AIRS,AIRS_C
HKD1_k127_6501087_17	1232410.KI421412_gene53	6.871e-59	218.0	COG1352@1|root,COG1352@2|Bacteria,1NQTI@1224|Proteobacteria,42UAX@68525|delta/epsilon subdivisions,2WQ4Q@28221|Deltaproteobacteria,43T51@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	Methyltransferase, chemotaxis proteins	cheR44H	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD1_k127_6501087_18	582515.KR51_00034220	5.668e-54	216.0	COG1750@1|root,COG1750@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,Lon_C,SdrD_B
HKD1_k127_6501087_22	643648.Slip_1376	6.523e-41	169.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Cu_amine_oxidN1,PD40
HKD1_k127_6501087_10	443143.GM18_3728	1.205e-75	269.0	COG0840@1|root,COG0840@2|Bacteria,1RA20@1224|Proteobacteria,42QNV@68525|delta/epsilon subdivisions,2WMT1@28221|Deltaproteobacteria,43T7D@69541|Desulfuromonadales	28221|Deltaproteobacteria	NT	histidine kinase HAMP region domain protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HKD1_k127_6501087_27	1297742.A176_01769	6.87e-12	73.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	difC	-	-	ko:K02659,ko:K03408	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
HKD1_k127_6501087_23	1123511.KB905845_gene2775	1.003e-40	163.0	COG2201@1|root,COG2201@2|Bacteria,1V3IU@1239|Firmicutes,4H4E7@909932|Negativicutes	909932|Negativicutes	NT	response regulator, receiver	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_6501087_21	1121106.JQKB01000014_gene5642	9.98e-43	165.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2JPP4@204441|Rhodospirillales	204441|Rhodospirillales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD1_k127_6501087_2	891968.Anamo_0288	2.011e-126	432.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,3T9SQ@508458|Synergistetes	508458|Synergistetes	T	Signal transducing histidine kinase homodimeric	-	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
HKD1_k127_6501087_28	1286171.EAL2_c13410	3.212e-09	66.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,25WFV@186806|Eubacteriaceae	186801|Clostridia	NT	CheC-like family	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
HKD1_k127_6501087_8	1125863.JAFN01000001_gene1414	8.298e-88	301.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,42Q6V@68525|delta/epsilon subdivisions,2WKIM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM asparagine synthase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	Asn_synthase,NAD_synthase,QueC
HKD1_k127_6501087_6	1499967.BAYZ01000076_gene806	9.275e-96	320.0	COG1028@1|root,COG1028@2|Bacteria,2NQY3@2323|unclassified Bacteria	2|Bacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD1_k127_6501087_20	1382356.JQMP01000003_gene1318	8.851e-49	185.0	COG3836@1|root,COG3836@2|Bacteria,2G925@200795|Chloroflexi,27YE5@189775|Thermomicrobia	189775|Thermomicrobia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.2.52	ko:K02510	ko00350,ko01120,map00350,map01120	-	R01645,R01647	RC00307,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_6501087_9	1151119.KB895489_gene505	2.05e-86	300.0	COG0477@1|root,COG2814@2|Bacteria,2H0CW@201174|Actinobacteria,1W8M8@1268|Micrococcaceae	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6501087_19	134676.ACPL_653	1.285e-51	193.0	COG0274@1|root,COG0274@2|Bacteria,2IARI@201174|Actinobacteria,4DIHM@85008|Micromonosporales	201174|Actinobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD1_k127_6501087_7	1496688.ER33_03200	3.701e-88	295.0	COG0605@1|root,COG0605@2|Bacteria,1G0N2@1117|Cyanobacteria,22S8H@167375|Cyanobium	1117|Cyanobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodB	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_6501087_12	1003200.AXXA_08234	1.208e-70	253.0	COG0451@1|root,COG0451@2|Bacteria,1MU1A@1224|Proteobacteria,2VHGA@28216|Betaproteobacteria,3T1XJ@506|Alcaligenaceae	28216|Betaproteobacteria	M	Male sterility protein	-	-	1.1.1.410	ko:K22025	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD1_k127_6501087_24	1168059.KB899087_gene2598	5.773e-28	120.0	COG3193@1|root,COG3193@2|Bacteria,1MY83@1224|Proteobacteria,2VA98@28211|Alphaproteobacteria,3EZHG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD1_k127_6522139_1	1499967.BAYZ01000163_gene6599	9.234e-74	256.0	COG0407@1|root,COG0407@2|Bacteria,2NRD5@2323|unclassified Bacteria	2|Bacteria	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_6522139_2	710686.Mycsm_03429	2.788e-29	121.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDH
HKD1_k127_6522139_0	882082.SaccyDRAFT_3038	1.036e-156	504.0	COG0667@1|root,COG0667@2|Bacteria,2GMT5@201174|Actinobacteria,4DZWM@85010|Pseudonocardiales	201174|Actinobacteria	C	Aldo/keto reductase family	-	-	-	ko:K19265	-	-	-	-	ko00000,ko01000	-	-	-	Aldo_ket_red
HKD1_k127_6523095_2	1267533.KB906738_gene2309	3.751e-104	342.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_6523095_3	1123508.JH636448_gene7487	1.563e-76	271.0	COG3464@1|root,COG3464@2|Bacteria,2J1EU@203682|Planctomycetes	203682|Planctomycetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
HKD1_k127_6523095_1	1510531.JQJJ01000010_gene2050	9.041e-153	498.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria,3JQP1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Domain of unknown function (DUF4070)	MA20_17485	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_6523095_0	269799.Gmet_0138	5.75e-159	522.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
HKD1_k127_6523095_5	1411123.JQNH01000001_gene3827	7.405e-11	74.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,2U6ZQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD1_k127_6523095_6	566461.SSFG_00273	0.0005282	52.0	2BTY3@1|root,32P6C@2|Bacteria,2I8RQ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6523095_4	391625.PPSIR1_32929	2.271e-40	156.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42U04@68525|delta/epsilon subdivisions,2WQA9@28221|Deltaproteobacteria,2YWN4@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6525776_0	314230.DSM3645_29316	5.941e-135	436.0	COG3588@1|root,COG3588@2|Bacteria	2|Bacteria	G	fructose-bisphosphate aldolase	fda	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HKD1_k127_6525776_1	869210.Marky_0919	3.052e-72	252.0	COG0036@1|root,COG0036@2|Bacteria,1WI8K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM Ribulose-phosphate 3 epimerase family	-	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_6525776_4	886293.Sinac_2019	5.137e-25	107.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_6525776_5	886293.Sinac_2019	3.154e-22	98.0	COG0698@1|root,COG0698@2|Bacteria,2IZSB@203682|Planctomycetes	203682|Planctomycetes	G	Ribose/Galactose Isomerase	-	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_6525776_3	1038860.AXAP01000029_gene680	3.887e-37	143.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,3JWJS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transketolase, pyrimidine binding domain	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_6525776_2	1267533.KB906745_gene56	1.171e-58	204.0	COG0021@1|root,COG0021@2|Bacteria,3Y38K@57723|Acidobacteria,2JHWX@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the transketolase family	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_6544485_4	357808.RoseRS_2771	2.348e-110	374.0	COG1457@1|root,COG1457@2|Bacteria,2G9KC@200795|Chloroflexi,376PN@32061|Chloroflexia	32061|Chloroflexia	F	Permease for cytosine/purines, uracil, thiamine, allantoin	-	-	-	-	-	-	-	-	-	-	-	-	Transp_cyt_pur
HKD1_k127_6544485_3	671143.DAMO_3127	1.694e-111	373.0	COG1408@1|root,COG1408@2|Bacteria,2NRGP@2323|unclassified Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_6544485_11	1111728.ATYS01000005_gene831	3.837e-06	53.0	28Z00@1|root,2ZKSP@2|Bacteria,1P60B@1224|Proteobacteria,1SVSK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6544485_6	671143.DAMO_1379	5.859e-80	273.0	COG2518@1|root,COG2518@2|Bacteria,2NP7E@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0030091,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_6544485_5	671143.DAMO_1380	4.669e-90	303.0	COG0496@1|root,COG0496@2|Bacteria,2NPCG@2323|unclassified Bacteria	2|Bacteria	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	GO:0003674,GO:0003824,GO:0004309,GO:0005488,GO:0005515,GO:0006139,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008252,GO:0008253,GO:0008254,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009125,GO:0009129,GO:0009131,GO:0009158,GO:0009161,GO:0009164,GO:0009166,GO:0009173,GO:0009175,GO:0009218,GO:0009222,GO:0009259,GO:0009261,GO:0009987,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0030145,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042578,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046049,GO:0046050,GO:0046131,GO:0046133,GO:0046135,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iSFxv_1172.SFxv_3035	SurE
HKD1_k127_6544485_14	104623.Ser39006_02209	0.0006972	44.0	COG0582@1|root,COG0582@2|Bacteria,1MU23@1224|Proteobacteria,1RMJ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the 'phage' integrase family	intA	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_int_SAM_3,Phage_integrase
HKD1_k127_6544485_9	278963.ATWD01000001_gene2589	1.043e-25	111.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_6544485_7	671143.DAMO_1382	2.11e-39	148.0	COG0776@1|root,COG0776@2|Bacteria,2NRPY@2323|unclassified Bacteria	2|Bacteria	K	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530,ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_6544485_13	557598.LHK_02113	0.0002169	53.0	COG3087@1|root,COG3087@2|Bacteria	2|Bacteria	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03749	-	-	-	-	ko00000	-	-	-	SPOR
HKD1_k127_6544485_2	429009.Adeg_0570	8.588e-120	400.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,42FC8@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_6544485_0	1207063.P24_14249	7.462e-138	452.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
HKD1_k127_6544485_1	1499967.BAYZ01000105_gene3493	1.052e-131	428.0	COG0444@1|root,COG0444@2|Bacteria	2|Bacteria	P	Belongs to the ABC transporter superfamily	oppD	-	-	ko:K02031,ko:K02032,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_6544485_8	1134474.O59_001868	1.675e-28	115.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,1RND6@1236|Gammaproteobacteria,1FFZ6@10|Cellvibrio	1236|Gammaproteobacteria	EP	N-terminal TM domain of oligopeptide transport permease C	oppC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iAF1260.b1245,iB21_1397.B21_01229,iEC55989_1330.EC55989_1342,iECBD_1354.ECBD_2377,iECB_1328.ECB_01219,iECDH10B_1368.ECDH10B_1307,iECDH1ME8569_1439.ECDH1ME8569_1185,iECD_1391.ECD_01219,iECIAI1_1343.ECIAI1_1264,iECO103_1326.ECO103_1345,iECO111_1330.ECO111_1572,iECO26_1355.ECO26_1756,iECSE_1348.ECSE_1293,iECSP_1301.ECSP_1637,iECUMN_1333.ECUMN_1542,iECW_1372.ECW_m1337,iECs_1301.ECs1745,iEKO11_1354.EKO11_2607,iETEC_1333.ETEC_1347,iEcDH1_1363.EcDH1_2403,iEcE24377_1341.EcE24377A_1393,iEcHS_1320.EcHS_A1354,iEcolC_1368.EcolC_2383,iG2583_1286.G2583_1517,iJO1366.b1245,iSSON_1240.SSON_1935,iUMNK88_1353.UMNK88_1565,iWFL_1372.ECW_m1337,iY75_1357.Y75_RS06515,iZ_1308.Z2021	BPD_transp_1,OppC_N
HKD1_k127_6555366_1	1121472.AQWN01000001_gene238	2.096e-47	177.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,261WJ@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_6555366_0	1246459.KB898355_gene4088	6.186e-65	236.0	COG4948@1|root,COG4948@2|Bacteria,1MW5B@1224|Proteobacteria,2UNXP@28211|Alphaproteobacteria,4BCKF@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily	gci	-	5.5.1.27	ko:K18983	ko00053,map00053	-	R10847	RC03287	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_6555366_2	1048339.KB913029_gene4480	2.99e-05	48.0	COG2030@1|root,COG2030@2|Bacteria	2|Bacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydrat_N,MaoC_dehydratas
HKD1_k127_6555545_10	273057.SSO2622	1.174e-11	71.0	COG2050@1|root,arCOG00777@2157|Archaea,2XSM0@28889|Crenarchaeota	28889|Crenarchaeota	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD1_k127_6555545_3	671143.DAMO_1052	2.778e-72	255.0	COG1085@1|root,COG1085@2|Bacteria,2NQQM@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4921)	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0896	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
HKD1_k127_6555545_9	935845.JADQ01000020_gene4189	2.197e-12	78.0	COG0613@1|root,COG0613@2|Bacteria,1V2U3@1239|Firmicutes,4HF4C@91061|Bacilli,26WDG@186822|Paenibacillaceae	91061|Bacilli	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6555545_4	1265505.ATUG01000003_gene610	5.207e-50	186.0	COG2041@1|root,COG2041@2|Bacteria	2|Bacteria	V	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	-	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HKD1_k127_6555545_1	1121430.JMLG01000004_gene921	8.879e-83	287.0	COG0371@1|root,COG0371@2|Bacteria,1TQFU@1239|Firmicutes,248KH@186801|Clostridia,261M9@186807|Peptococcaceae	186801|Clostridia	C	PFAM Iron-containing alcohol dehydrogenase	dhaD	-	1.1.1.6	ko:K00005,ko:K08317	ko00561,ko00640,ko01100,map00561,map00640,map01100	-	R01034,R10715,R10717	RC00029,RC00117,RC00670	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_6555545_6	1380354.JIAN01000009_gene3815	1.913e-38	150.0	COG1595@1|root,COG1595@2|Bacteria,2GJ02@201174|Actinobacteria,4F0X4@85016|Cellulomonadaceae	201174|Actinobacteria	K	RNA polymerase sigma factor, sigma-70 family	sigH	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005618,GO:0005623,GO:0006355,GO:0006950,GO:0006979,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0016987,GO:0019219,GO:0019222,GO:0030312,GO:0031323,GO:0031326,GO:0033554,GO:0034605,GO:0043254,GO:0044087,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0051409,GO:0051716,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6555545_11	1151127.KB906339_gene905	1.104e-09	70.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,1SFJZ@1236|Gammaproteobacteria,1YTFZ@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6555545_0	56780.SYN_02675	7.499e-256	799.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,42M4F@68525|delta/epsilon subdivisions,2WKK3@28221|Deltaproteobacteria,2MQAP@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	PFAM UDP-glucose GDP-mannose dehydrogenase	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_6555545_8	1121396.KB892935_gene3805	3.776e-22	104.0	COG1917@1|root,COG1917@2|Bacteria,1N2JS@1224|Proteobacteria,42TR3@68525|delta/epsilon subdivisions,2WQ4M@28221|Deltaproteobacteria,2MKQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_6555545_2	1031288.AXAA01000013_gene514	5.144e-81	278.0	COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia,36F9G@31979|Clostridiaceae	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
HKD1_k127_6555545_5	595460.RRSWK_02165	1.42e-47	179.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_6555545_7	1121405.dsmv_2310	3.31e-24	109.0	COG2271@1|root,COG2271@2|Bacteria,1QTW2@1224|Proteobacteria,42U0W@68525|delta/epsilon subdivisions,2WQRX@28221|Deltaproteobacteria,2MPQV@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6580967_17	1231185.BAMP01000024_gene2570	3.381e-10	69.0	COG1653@1|root,COG1653@2|Bacteria,1QKXW@1224|Proteobacteria,2U3F1@28211|Alphaproteobacteria,43IH5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_6580967_12	1229204.AMYY01000023_gene2261	6.44e-59	216.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TQZY@28211|Alphaproteobacteria,4BQJF@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Carbohydrate ABC transporter membrane protein 1, CUT1 family	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6580967_10	1219084.AP014508_gene2041	9.984e-65	233.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	lacG	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_6580967_0	696281.Desru_2413	8.903e-154	505.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,260AW@186807|Peptococcaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	-	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_6580967_3	867903.ThesuDRAFT_01460	4.236e-107	359.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,3WCYS@538999|Clostridiales incertae sedis	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD1_k127_6580967_11	671143.DAMO_1613	2.911e-61	215.0	COG1143@1|root,COG1143@2|Bacteria,2NRUK@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	ndhI	-	1.6.5.3	ko:K00338,ko:K05580	ko00190,ko01100,map00190,map01100	M00144,M00145	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HKD1_k127_6580967_8	671143.DAMO_1614	1.092e-80	273.0	COG0377@1|root,COG0377@2|Bacteria,2NPEF@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_6580967_4	330214.NIDE3200	1.57e-103	347.0	COG1234@1|root,COG1234@2|Bacteria,3J113@40117|Nitrospirae	40117|Nitrospirae	S	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	-
HKD1_k127_6580967_16	671143.DAMO_1510	4.35e-29	120.0	COG0607@1|root,COG0607@2|Bacteria,2NRI8@2323|unclassified Bacteria	2|Bacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_6580967_13	688269.Theth_1106	6.892e-57	209.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	iolI	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_6580967_1	1380394.JADL01000001_gene1950	5.837e-150	484.0	COG3616@1|root,COG3616@2|Bacteria,1MVQE@1224|Proteobacteria,2TSQ3@28211|Alphaproteobacteria,2JR8N@204441|Rhodospirillales	204441|Rhodospirillales	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HKD1_k127_6580967_9	1125973.JNLC01000010_gene1863	1.054e-77	267.0	COG0600@1|root,COG0600@2|Bacteria,1NJ59@1224|Proteobacteria,2TUZ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport system permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_6580967_2	1297569.MESS2_90005	2.791e-107	358.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TRXZ@28211|Alphaproteobacteria,43QYM@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_6580967_15	331869.BAL199_19061	2.947e-35	145.0	COG0600@1|root,COG0600@2|Bacteria,1R546@1224|Proteobacteria,2TTRM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_6580967_5	1121033.AUCF01000006_gene4242	3.2e-99	335.0	COG0715@1|root,COG0715@2|Bacteria,1R4AB@1224|Proteobacteria,2U2A0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	ABC-type nitrate sulfonate bicarbonate transport systems periplasmic	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_6580967_6	1449126.JQKL01000004_gene515	1.412e-94	322.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia	186801|Clostridia	C	Belongs to the LDH2 MDH2 oxidoreductase family	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_6580967_7	8081.XP_008416521.1	1.113e-90	307.0	COG0329@1|root,2QWNS@2759|Eukaryota,399HY@33154|Opisthokonta,3BGNT@33208|Metazoa,3CUM9@33213|Bilateria,481FN@7711|Chordata,48XJ6@7742|Vertebrata,4A1NB@7898|Actinopterygii	33208|Metazoa	T	4-hydroxy-2-oxoglutarate aldolase	HOGA1	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0006081,GO:0006082,GO:0006090,GO:0006520,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008700,GO:0009056,GO:0009058,GO:0009063,GO:0009436,GO:0009987,GO:0016053,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0016833,GO:0019470,GO:0019471,GO:0019752,GO:0031974,GO:0032787,GO:0033609,GO:0042219,GO:0042802,GO:0042803,GO:0042866,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0046185,GO:0046394,GO:0046395,GO:0046487,GO:0046983,GO:0070013,GO:0071704,GO:0072329,GO:0072330,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901605,GO:1901606	4.1.3.16	ko:K18123	ko00330,ko00630,ko01100,map00330,map00630,map01100	-	R00470,R00471	RC00307,RC00308	ko00000,ko00001,ko01000	-	-	-	DHDPS
HKD1_k127_6580967_18	1185876.BN8_06213	6.804e-10	72.0	COG1914@1|root,COG1914@2|Bacteria,4PJFT@976|Bacteroidetes,47N82@768503|Cytophagia	976|Bacteroidetes	P	H( )-stimulated, divalent metal cation uptake system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6580967_14	530564.Psta_2949	2.4e-45	168.0	COG0075@1|root,COG0075@2|Bacteria,2IYEK@203682|Planctomycetes	203682|Planctomycetes	E	Aminotransferase class-V	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_6588655_0	1089553.Tph_c21390	2.844e-259	814.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,42ER6@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_6593195_0	269799.Gmet_0767	1.601e-215	678.0	COG0433@1|root,COG0433@2|Bacteria,1MU59@1224|Proteobacteria,42MTV@68525|delta/epsilon subdivisions,2WKVP@28221|Deltaproteobacteria,43S8J@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
HKD1_k127_6593195_2	97139.C824_04132	9.641e-33	137.0	COG1028@1|root,COG1028@2|Bacteria,1UETI@1239|Firmicutes,24BBC@186801|Clostridia,36K9V@31979|Clostridiaceae	186801|Clostridia	IQ	Enoyl-(Acyl carrier protein) reductase	fabG4	-	1.1.1.100,1.1.1.304,1.1.1.385,1.1.1.76	ko:K00059,ko:K18009,ko:K19548	ko00061,ko00333,ko00650,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00650,map00780,map01040,map01100,map01130,map01212	M00083,M00572,M00787	R03707,R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R09078,R10116,R10120,R10505,R10917,R11671	RC00029,RC00117,RC00154,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6593195_1	411464.DESPIG_02584	2.083e-77	268.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,42M37@68525|delta/epsilon subdivisions,2WK30@28221|Deltaproteobacteria,2MFW3@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	D-galactarate dehydratase altronate hydrolase domain protein	-	-	4.2.1.7	ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
HKD1_k127_6632711_1	335543.Sfum_1464	2.133e-60	218.0	COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_4,Sigma54_activat
HKD1_k127_6632711_2	398512.JQKC01000002_gene1989	2.756e-43	164.0	COG0698@1|root,COG0698@2|Bacteria,1V3HE@1239|Firmicutes,24JWT@186801|Clostridia,3WJA1@541000|Ruminococcaceae	186801|Clostridia	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_6632711_0	158190.SpiGrapes_2018	1.284e-81	280.0	COG1082@1|root,COG1082@2|Bacteria,2J8EP@203691|Spirochaetes	203691|Spirochaetes	G	TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD1_k127_6632711_3	392499.Swit_1426	1.718e-08	57.0	COG1028@1|root,COG1028@2|Bacteria,1MU73@1224|Proteobacteria,2TV6T@28211|Alphaproteobacteria,2K26C@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6649600_2	1041146.ATZB01000088_gene1306	2.353e-06	55.0	COG3335@1|root,COG3335@2|Bacteria,1P76X@1224|Proteobacteria,2U16U@28211|Alphaproteobacteria,4BC2J@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase and inactivated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
HKD1_k127_6649600_1	420324.KI912069_gene6310	1.307e-26	121.0	COG3415@1|root,COG3415@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K01152	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_23,HTH_Tnp_IS630
HKD1_k127_6649600_0	349163.Acry_2108	8.65e-197	622.0	COG3328@1|root,COG3328@2|Bacteria,1MU4P@1224|Proteobacteria,2TUQT@28211|Alphaproteobacteria,2JPZG@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase mutator type	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD1_k127_6651639_6	1265505.ATUG01000001_gene2910	5.41e-40	166.0	COG2911@1|root,COG2911@2|Bacteria,1PQTA@1224|Proteobacteria,42PYT@68525|delta/epsilon subdivisions,2WIZ6@28221|Deltaproteobacteria,2MJ1Q@213118|Desulfobacterales	28221|Deltaproteobacteria	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD1_k127_6651639_3	1499967.BAYZ01000057_gene4682	1.631e-85	316.0	COG4775@1|root,COG4775@2|Bacteria,2NNNW@2323|unclassified Bacteria	2|Bacteria	M	Surface antigen	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_6651639_9	1267535.KB906767_gene3598	4.309e-05	55.0	COG0760@1|root,COG0760@2|Bacteria,3Y4KY@57723|Acidobacteria	57723|Acidobacteria	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3
HKD1_k127_6651639_5	391937.NA2_11774	5.959e-51	190.0	COG3836@1|root,COG3836@2|Bacteria,1MUSG@1224|Proteobacteria,2UTAA@28211|Alphaproteobacteria,43RJC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HKD1_k127_6651639_0	1500259.JQLD01000010_gene4821	3.34e-145	477.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,4B9MM@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	protein conserved in bacteria	tctA	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_6651639_8	408672.NBCG_00489	8.043e-11	72.0	2CQ1K@1|root,32SKA@2|Bacteria,2GSFN@201174|Actinobacteria	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_6651639_4	1205680.CAKO01000037_gene1303	9.131e-69	246.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria,2JZJF@204441|Rhodospirillales	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_6651639_1	1131553.JIBI01000032_gene2309	3.387e-124	418.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VK3I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Chloride channel	clcA_1	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD1_k127_6651639_2	573413.Spirs_3602	3.423e-103	346.0	COG1063@1|root,COG1063@2|Bacteria,2J5R7@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Alcohol dehydrogenase GroES-like	-	-	1.1.1.14,1.1.1.303,1.1.1.4	ko:K00004,ko:K00008	ko00040,ko00051,ko00650,ko01100,map00040,map00051,map00650,map01100	M00014	R00875,R01896,R02855,R02946,R10504	RC00085,RC00102,RC00205,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6651639_7	859657.RPSI07_3143	1.08e-27	121.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2VH6V@28216|Betaproteobacteria,1K2D0@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD1_k127_6662599_0	1283300.ATXB01000001_gene385	2.104e-121	400.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1XEIK@135618|Methylococcales	135618|Methylococcales	KT	PFAM RNA polymerase sigma factor 54, interaction	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_4,Sigma54_activat
HKD1_k127_6662599_8	1185876.BN8_02773	7.822e-06	48.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,47JRM@768503|Cytophagia	976|Bacteroidetes	T	sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_9,Response_reg,Sigma54_activat
HKD1_k127_6662599_7	1232410.KI421421_gene3332	3.482e-09	64.0	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,42TXG@68525|delta/epsilon subdivisions,2WQI4@28221|Deltaproteobacteria,43W20@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_6662599_5	522306.CAP2UW1_1258	1.199e-26	111.0	2ECC0@1|root,336AD@2|Bacteria,1NH5F@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6662599_1	391038.Bphy_4532	6.815e-91	309.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,2VZD7@28216|Betaproteobacteria,1K4IW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD1_k127_6662599_2	391038.Bphy_4533	6.278e-59	219.0	2EB3I@1|root,30WIU@2|Bacteria,1NY00@1224|Proteobacteria,2W3MQ@28216|Betaproteobacteria,1KCUS@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6662599_6	1267533.KB906735_gene4538	4.044e-17	90.0	2C6A3@1|root,34625@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6662599_4	1454004.AW11_03085	5.376e-44	163.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_6709115_0	335543.Sfum_2649	1.617e-124	404.0	COG0160@1|root,COG0160@2|Bacteria,1MWY6@1224|Proteobacteria,42MB7@68525|delta/epsilon subdivisions,2WJVU@28221|Deltaproteobacteria,2MQ96@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_6709115_2	1166948.JPZL01000002_gene1201	8.766e-17	85.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1XKJ1@135619|Oceanospirillales	135619|Oceanospirillales	L	DNA polymerase III subunit chi	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HKD1_k127_6709115_1	1125863.JAFN01000001_gene1061	5.921e-98	325.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,42MSC@68525|delta/epsilon subdivisions,2WJAH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC transporter related	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_6710543_2	519442.Huta_2604	1.484e-74	259.0	COG1941@1|root,arCOG02472@2157|Archaea,2XZ11@28890|Euryarchaeota,241CN@183963|Halobacteria	183963|Halobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_6710543_0	1379281.AVAG01000028_gene129	5.754e-145	472.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,42RHV@68525|delta/epsilon subdivisions,2WNH5@28221|Deltaproteobacteria,2MA5W@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Nickel-dependent hydrogenase	hyhL	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
HKD1_k127_6710543_3	519442.Huta_2606	3.824e-18	94.0	COG0680@1|root,arCOG04429@2157|Archaea	2157|Archaea	C	PFAM peptidase M52 hydrogen uptake protein	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD1_k127_6710543_1	357804.Ping_2617	2.695e-130	423.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,2QIGA@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	Citrate synthase, C-terminal domain	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_6719907_3	344747.PM8797T_23489	3.191e-20	102.0	COG0515@1|root,COG0515@2|Bacteria,2J200@203682|Planctomycetes	203682|Planctomycetes	KLT	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	NERD,Pkinase,RNA_pol_A_CTD
HKD1_k127_6719907_0	314230.DSM3645_16020	2.692e-112	379.0	COG3385@1|root,COG3385@2|Bacteria,2IYW8@203682|Planctomycetes	203682|Planctomycetes	L	COG3385 FOG Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_6719907_2	1174528.JH992893_gene6005	9.988e-30	124.0	COG3335@1|root,COG3335@2|Bacteria,1G5I5@1117|Cyanobacteria	1117|Cyanobacteria	L	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_6719907_1	485913.Krac_7935	1.358e-78	277.0	COG3335@1|root,COG3335@2|Bacteria,2G8X3@200795|Chloroflexi	200795|Chloroflexi	L	PFAM Rhodopirellula transposase family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_6719907_4	326298.Suden_0947	6.437e-07	54.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,42NNU@68525|delta/epsilon subdivisions,2YN8D@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_24
HKD1_k127_68002_3	1232410.KI421412_gene82	1.096e-11	68.0	COG2026@1|root,COG2026@2|Bacteria,1NP1I@1224|Proteobacteria,437H9@68525|delta/epsilon subdivisions,2WVKQ@28221|Deltaproteobacteria,43V3Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD1_k127_68002_2	1089553.Tph_c26030	3.435e-17	89.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_68002_1	56110.Oscil6304_4971	3.021e-24	115.0	COG0457@1|root,COG0457@2|Bacteria	56110.Oscil6304_4971|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_68002_0	1047013.AQSP01000038_gene1970	1.558e-32	130.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD1_k127_6816608_4	1346791.M529_23900	3.091e-11	76.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWBJ@28211|Alphaproteobacteria,2KEEC@204457|Sphingomonadales	204457|Sphingomonadales	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,MASE1,PAS_3,PAS_4,Response_reg
HKD1_k127_6816608_3	240015.ACP_2858	5.146e-15	88.0	COG0810@1|root,COG4219@1|root,COG0810@2|Bacteria,COG4219@2|Bacteria,3Y62Q@57723|Acidobacteria,2JM1D@204432|Acidobacteriia	204432|Acidobacteriia	KMT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
HKD1_k127_6816608_1	204669.Acid345_4143	1.673e-60	217.0	COG1399@1|root,COG1399@2|Bacteria,3Y4KJ@57723|Acidobacteria,2JJ8Y@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD1_k127_6816608_2	204669.Acid345_4144	1.395e-26	109.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria,2JJZ9@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_6816608_0	204669.Acid345_4145	7.186e-148	475.0	COG0416@1|root,COG0416@2|Bacteria,3Y3MM@57723|Acidobacteria,2JHTJ@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD1_k127_6816608_5	1150626.PHAMO_270158	1.177e-10	62.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,2JQWI@204441|Rhodospirillales	204441|Rhodospirillales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645,ko:K15327	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Acyl_transf_1
HKD1_k127_6821120_3	36809.MAB_2627c	2.03e-43	165.0	COG3707@1|root,COG3707@2|Bacteria,2GK7T@201174|Actinobacteria,235QN@1762|Mycobacteriaceae	201174|Actinobacteria	T	response regulator	pdtaR	GO:0000160,GO:0003674,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0007154,GO:0007165,GO:0008150,GO:0009987,GO:0016020,GO:0023052,GO:0030312,GO:0035556,GO:0040007,GO:0043167,GO:0043168,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0065007,GO:0071944	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HKD1_k127_6821120_4	479434.Sthe_0992	1.034e-35	158.0	COG2203@1|root,COG3605@1|root,COG3920@1|root,COG2203@2|Bacteria,COG3605@2|Bacteria,COG3920@2|Bacteria,2G67M@200795|Chloroflexi,27XHF@189775|Thermomicrobia	189775|Thermomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2
HKD1_k127_6821120_5	1394178.AWOO02000013_gene7835	1.864e-08	59.0	COG1584@1|root,COG1584@2|Bacteria,2IIIX@201174|Actinobacteria	201174|Actinobacteria	S	PFAM GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD1_k127_6821120_6	1394178.AWOO02000013_gene7835	1.094e-05	49.0	COG1584@1|root,COG1584@2|Bacteria,2IIIX@201174|Actinobacteria	201174|Actinobacteria	S	PFAM GPR1 FUN34 yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD1_k127_6821120_0	1040989.AWZU01000004_gene7058	1.143e-117	393.0	COG2223@1|root,COG2223@2|Bacteria,1MVFQ@1224|Proteobacteria,2TR8Q@28211|Alphaproteobacteria,3JTQJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HKD1_k127_6821120_1	266117.Rxyl_0921	1.415e-112	368.0	COG1013@1|root,COG1013@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016054,GO:0016491,GO:0016625,GO:0016903,GO:0019752,GO:0033609,GO:0033611,GO:0043436,GO:0043648,GO:0043649,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0046395,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:1901575	1.2.7.1,1.2.7.10	ko:K00170,ko:K19071	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_6840925_0	420324.KI912061_gene6197	1.076e-172	576.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,1JR57@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Abhydrolase_1,Guanylate_cyc,TPR_4
HKD1_k127_6840925_1	479434.Sthe_3121	1.258e-81	275.0	COG0554@1|root,COG0554@2|Bacteria,2G5TV@200795|Chloroflexi,27XT1@189775|Thermomicrobia	189775|Thermomicrobia	H	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	-	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD1_k127_6847802_2	1057002.KB905370_gene3177	1.357e-06	52.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,4B9EZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter, ATP-binding protein	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_6847802_1	525909.Afer_1833	4.255e-22	102.0	COG2246@1|root,COG2246@2|Bacteria,2HGRJ@201174|Actinobacteria,4CNUB@84992|Acidimicrobiia	84992|Acidimicrobiia	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD1_k127_6847802_0	717606.PaecuDRAFT_4580	6.705e-26	113.0	COG2271@1|root,COG2271@2|Bacteria,1TRHT@1239|Firmicutes,4HDG8@91061|Bacilli,275KZ@186822|Paenibacillaceae	91061|Bacilli	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_6860614_6	941449.dsx2_2962	7.631e-08	61.0	2BJV9@1|root,32E7H@2|Bacteria,1QTNM@1224|Proteobacteria,43ETJ@68525|delta/epsilon subdivisions,2X1Q8@28221|Deltaproteobacteria,2MFGB@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6860614_2	596151.DesfrDRAFT_1896	1.388e-131	433.0	COG1148@1|root,COG1148@2|Bacteria,1R99M@1224|Proteobacteria,42Q2T@68525|delta/epsilon subdivisions,2WJTB@28221|Deltaproteobacteria,2MEIA@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Pyr_redox_2
HKD1_k127_6860614_0	1379698.RBG1_1C00001G0047	4.738e-217	683.0	COG3259@1|root,COG3259@2|Bacteria,2NQGS@2323|unclassified Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	-	-	1.8.98.5	ko:K14126	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_6860614_4	767817.Desgi_1165	3.721e-99	342.0	COG1941@1|root,COG1941@2|Bacteria,1V21E@1239|Firmicutes,24GWD@186801|Clostridia	186801|Clostridia	C	PFAM NADH ubiquinone oxidoreductase, 20	-	-	1.8.98.5	ko:K14128	ko00680,map00680	-	R00019,R11943	RC00011	ko00000,ko00001,ko01000	-	-	-	Oxidored_q6
HKD1_k127_6860614_5	477974.Daud_1653	4.796e-53	191.0	COG1908@1|root,COG1908@2|Bacteria,1V7I6@1239|Firmicutes,24JV2@186801|Clostridia,261SC@186807|Peptococcaceae	186801|Clostridia	C	PFAM methyl-viologen-reducing hydrogenase delta subunit	-	-	1.8.98.5,1.8.98.6	ko:K14127	ko00680,map00680	-	R00019,R11943,R11944	RC00011	ko00000,ko00001,ko01000	-	-	-	Fer4,FlpD,HTH_5
HKD1_k127_6860614_1	429009.Adeg_1001	2.226e-176	574.0	COG1148@1|root,COG1148@2|Bacteria,1VPAD@1239|Firmicutes,25B2G@186801|Clostridia,42FM3@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_7,Pyr_redox_2
HKD1_k127_6860614_3	1173028.ANKO01000017_gene232	3.132e-101	336.0	COG0378@1|root,COG0378@2|Bacteria,1G2X6@1117|Cyanobacteria,1H8P3@1150|Oscillatoriales	1117|Cyanobacteria	KO	Ni2 binding GTPase involved in regulation of expression and maturation of urease and hydrogenase	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD1_k127_6862552_0	234267.Acid_2381	5.642e-165	527.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.303	ko:K20421	ko01059,ko01130,map01059,map01130	M00830	R10963	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
HKD1_k127_6905809_0	589924.Ferp_0126	6.876e-48	181.0	COG0348@1|root,arCOG02772@2157|Archaea,2Y7DD@28890|Euryarchaeota,246PC@183980|Archaeoglobi	183980|Archaeoglobi	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_5
HKD1_k127_6905809_3	1120956.JHZK01000002_gene853	4.504e-10	70.0	COG1633@1|root,COG1633@2|Bacteria,1MUET@1224|Proteobacteria,2TQMZ@28211|Alphaproteobacteria,1JPXH@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Rubrerythrin	mbfA	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
HKD1_k127_6905809_2	653733.Selin_0567	1.787e-21	102.0	COG0348@1|root,COG1622@1|root,COG0348@2|Bacteria,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	vnfA	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1,Fer4_5,Sigma54_activat,cNMP_binding
HKD1_k127_6905809_1	331678.Cphamn1_0650	5.574e-36	146.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_6911788_7	357808.RoseRS_4428	7.136e-82	281.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6911788_10	234267.Acid_4807	4.02e-58	209.0	COG0705@1|root,COG0705@2|Bacteria,3Y5A9@57723|Acidobacteria	57723|Acidobacteria	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_6911788_8	344747.PM8797T_13812	1.682e-80	283.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_6911788_0	1144275.COCOR_06766	1.055e-181	588.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
HKD1_k127_6911788_11	1089553.Tph_c02670	5.608e-53	201.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,42EVR@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851,ko:K13007	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD1_k127_6911788_9	882083.SacmaDRAFT_3584	1.15e-62	226.0	COG0702@1|root,COG0702@2|Bacteria,2IQ0Z@201174|Actinobacteria	201174|Actinobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Methyltransf_21,NAD_binding_10
HKD1_k127_6911788_4	106370.Francci3_1304	1.274e-117	391.0	COG0438@1|root,COG0438@2|Bacteria,2GMI6@201174|Actinobacteria,4ETEE@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	ko:K00786	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glycos_transf_1
HKD1_k127_6911788_2	378806.STAUR_1668	7.658e-129	421.0	COG0381@1|root,COG0381@2|Bacteria,1QUYI@1224|Proteobacteria,42MSY@68525|delta/epsilon subdivisions,2WJXR@28221|Deltaproteobacteria,2YVAN@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	mnaA	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HKD1_k127_6911788_1	926569.ANT_20160	1.868e-166	531.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	wecE	GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0005976,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009059,GO:0009246,GO:0009987,GO:0016051,GO:0016740,GO:0016769,GO:0019180,GO:0019842,GO:0030170,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046378,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901363,GO:1901576	2.6.1.59	ko:K02805	-	-	-	-	ko00000,ko01000,ko01007	-	-	iE2348C_1286.E2348C_4092,iEC55989_1330.EC55989_4263,iECIAI1_1343.ECIAI1_3978,iECIAI39_1322.ECIAI39_2996,iECO103_1326.ECO103_4373,iECO111_1330.ECO111_4617,iECO26_1355.ECO26_4795,iECUMN_1333.ECUMN_4316,iECW_1372.ECW_m4089,iEKO11_1354.EKO11_4565,iSSON_1240.SSON_3963,iWFL_1372.ECW_m4089	DegT_DnrJ_EryC1
HKD1_k127_6911788_12	926569.ANT_20150	2.699e-40	161.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_6911788_16	390989.JOEG01000001_gene5344	0.0001298	51.0	COG2227@1|root,COG2227@2|Bacteria,2I4VV@201174|Actinobacteria,4DMR7@85008|Micromonosporales	201174|Actinobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_6911788_14	941449.dsx2_1094	4.093e-10	63.0	COG0500@1|root,COG2226@2|Bacteria,1N867@1224|Proteobacteria,4310U@68525|delta/epsilon subdivisions	1224|Proteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_6911788_3	926569.ANT_20140	2.474e-127	415.0	COG0463@1|root,COG0463@2|Bacteria,2G5JH@200795|Chloroflexi	2|Bacteria	M	PFAM Glycosyl transferase family 2	wcqE	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HKD1_k127_6911788_17	545276.KB898724_gene1808	0.0001728	53.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1WVZJ@135613|Chromatiales	135613|Chromatiales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD1_k127_6911788_15	1122939.ATUD01000004_gene3840	1.458e-05	57.0	29YC3@1|root,30K6G@2|Bacteria,2I7A8@201174|Actinobacteria,4CTY9@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6911788_5	1333998.M2A_2670	2.217e-106	366.0	COG0438@1|root,COG0438@2|Bacteria,1PDR7@1224|Proteobacteria,2U1R4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_6911788_6	247490.KSU1_D0301	7.154e-99	337.0	COG2244@1|root,COG2244@2|Bacteria	2|Bacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_6911788_13	1040989.AWZU01000056_gene3833	1.899e-13	76.0	COG0500@1|root,COG2226@2|Bacteria,1QWJE@1224|Proteobacteria,2U37M@28211|Alphaproteobacteria,3K1YX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_6990691_2	1173022.Cri9333_4305	8.676e-63	228.0	COG2348@1|root,COG2348@2|Bacteria,1G1W5@1117|Cyanobacteria,1HESZ@1150|Oscillatoriales	1117|Cyanobacteria	V	FemAB family	-	-	-	-	-	-	-	-	-	-	-	-	FemAB
HKD1_k127_6990691_4	439235.Dalk_0791	1.518e-28	126.0	COG3766@1|root,COG3766@2|Bacteria,1Q8XV@1224|Proteobacteria,42M8R@68525|delta/epsilon subdivisions,2WMH7@28221|Deltaproteobacteria,2MII9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of Unknown Function (DUF350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF350
HKD1_k127_6990691_3	66875.JODY01000041_gene1901	2.002e-46	179.0	COG0329@1|root,COG0329@2|Bacteria,2GJDB@201174|Actinobacteria	201174|Actinobacteria	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_6990691_0	1380394.JADL01000001_gene2213	1.313e-143	471.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales	28211|Alphaproteobacteria	E	Belongs to the ABC transporter superfamily	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_6990691_1	266779.Meso_4488	6.24e-71	243.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,2TR0J@28211|Alphaproteobacteria,43IM6@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	EP	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_6992558_4	1499967.BAYZ01000002_gene5896	6.321e-63	220.0	COG0395@1|root,COG0395@2|Bacteria	1499967.BAYZ01000002_gene5896|-	P	glycerophosphodiester transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6992558_2	1007103.AFHW01000104_gene5120	4.505e-80	276.0	COG1175@1|root,COG1175@2|Bacteria,1UY5Z@1239|Firmicutes,4HDNY@91061|Bacilli,26UBB@186822|Paenibacillaceae	91061|Bacilli	G	ABC transporter permease	-	-	-	ko:K05814	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	BPD_transp_1
HKD1_k127_6992558_3	338963.Pcar_2439	4.981e-64	230.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,42R1W@68525|delta/epsilon subdivisions,2WMQ4@28221|Deltaproteobacteria,43SF7@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_6992558_1	1120746.CCNL01000008_gene829	3.341e-99	336.0	COG3842@1|root,COG3842@2|Bacteria,2NQSQ@2323|unclassified Bacteria	2|Bacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.30,3.6.3.31	ko:K02010,ko:K11072	ko02010,map02010	M00190,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD1_k127_6992558_0	44251.PDUR_12070	6.919e-159	517.0	COG1178@1|root,COG1178@2|Bacteria,1TPMX@1239|Firmicutes,4HA2U@91061|Bacilli,274ZY@186822|Paenibacillaceae	91061|Bacilli	P	ABC transporter permease	-	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_7020791_3	1382356.JQMP01000004_gene188	7.615e-24	108.0	COG0436@1|root,COG0436@2|Bacteria,2G5MC@200795|Chloroflexi,27YSW@189775|Thermomicrobia	189775|Thermomicrobia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_7020791_0	706587.Desti_4883	6.576e-113	377.0	COG0477@1|root,COG2814@2|Bacteria,1MUZ8@1224|Proteobacteria,42YIF@68525|delta/epsilon subdivisions,2WU4S@28221|Deltaproteobacteria,2MQET@213462|Syntrophobacterales	28221|Deltaproteobacteria	EGP	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HKD1_k127_7020791_1	330214.NIDE0246	1.769e-84	297.0	COG1472@1|root,COG1472@2|Bacteria,3J0MK@40117|Nitrospirae	40117|Nitrospirae	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD1_k127_7034320_0	314230.DSM3645_25744	2.534e-210	664.0	COG1048@1|root,COG1048@2|Bacteria,2IY29@203682|Planctomycetes	203682|Planctomycetes	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_7034320_13	1177181.T9A_00609	4.663e-23	113.0	COG1075@1|root,COG1075@2|Bacteria,1NGMF@1224|Proteobacteria	1224|Proteobacteria	S	Lecithin:cholesterol acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	LCAT
HKD1_k127_7034320_10	1123248.KB893314_gene3458	3.11e-43	168.0	COG2318@1|root,COG2318@2|Bacteria,4NNRD@976|Bacteroidetes,1ITIY@117747|Sphingobacteriia	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
HKD1_k127_7034320_9	1522072.IL54_2774	2.371e-62	227.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U2WH@28211|Alphaproteobacteria,2KCB6@204457|Sphingomonadales	204457|Sphingomonadales	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HKD1_k127_7034320_3	330214.NIDE0773	1.577e-89	310.0	COG1680@1|root,COG1680@2|Bacteria,3J131@40117|Nitrospirae	40117|Nitrospirae	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_7034320_2	589865.DaAHT2_1931	7.382e-136	449.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_7034320_12	380749.HY04AAS1_1394	4.242e-29	128.0	COG3411@1|root,COG3411@2|Bacteria,2G541@200783|Aquificae	200783|Aquificae	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HKD1_k127_7034320_1	671143.DAMO_1607	5.057e-175	556.0	COG1104@1|root,COG1104@2|Bacteria,2NNVR@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	iscS	GO:0001522,GO:0003674,GO:0003824,GO:0004123,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006790,GO:0006807,GO:0008033,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009000,GO:0009058,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016226,GO:0016740,GO:0016769,GO:0016782,GO:0016783,GO:0016829,GO:0016846,GO:0018130,GO:0018131,GO:0019842,GO:0022607,GO:0030170,GO:0031071,GO:0031119,GO:0031163,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046484,GO:0048037,GO:0050662,GO:0051186,GO:0070279,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097163,GO:0140104,GO:1901360,GO:1901363	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	iPC815.YPO2896,iYL1228.KPN_02862	Aminotran_5
HKD1_k127_7034320_4	1121430.JMLG01000014_gene1929	5.852e-82	287.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_7034320_6	1205680.CAKO01000040_gene1113	1.249e-78	272.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,2JS5W@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7034320_8	1009370.ALO_08153	1.267e-72	261.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4H353@909932|Negativicutes	1239|Firmicutes	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7034320_7	1244869.H261_06509	7.255e-76	265.0	COG0559@1|root,COG0559@2|Bacteria,1P3FU@1224|Proteobacteria,2TT3V@28211|Alphaproteobacteria,2JTCX@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0559 Branched-chain amino acid ABC-type transport system, permease components	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_7034320_5	1380394.JADL01000003_gene5191	6.643e-80	284.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U16N@28211|Alphaproteobacteria,2JVNK@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_7034320_11	330214.NIDE4326	2.069e-38	147.0	2CK1C@1|root,32SJA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7042984_0	1380394.JADL01000001_gene2475	6.384e-77	266.0	COG1028@1|root,COG1028@2|Bacteria,1PI1B@1224|Proteobacteria,2V7T1@28211|Alphaproteobacteria,2JX74@204441|Rhodospirillales	204441|Rhodospirillales	IQ	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_7042984_1	631362.Thi970DRAFT_04806	9.881e-07	50.0	COG5579@1|root,COG5579@2|Bacteria,1RGXV@1224|Proteobacteria,1S6K5@1236|Gammaproteobacteria,1X0TT@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1810
HKD1_k127_70470_1	1047013.AQSP01000091_gene657	6.01e-54	211.0	COG5002@1|root,COG5002@2|Bacteria,2NNKK@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	rprX	-	2.7.13.3	ko:K02484,ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_3,HAMP,HATPase_c,HisKA,Response_reg
HKD1_k127_70470_0	234267.Acid_6247	7.896e-103	340.0	COG0673@1|root,COG0673@2|Bacteria,3Y39X@57723|Acidobacteria	57723|Acidobacteria	S	PFAM oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_7068447_1	1038858.AXBA01000001_gene3332	3.367e-115	380.0	COG3181@1|root,COG3181@2|Bacteria,1QZZP@1224|Proteobacteria,2V8Q6@28211|Alphaproteobacteria,3F11U@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_7068447_2	639283.Snov_1726	3.342e-27	117.0	29Z1U@1|root,30KZ7@2|Bacteria,1PMZH@1224|Proteobacteria,2VCW7@28211|Alphaproteobacteria,3F1PV@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_7068447_0	1038858.AXBA01000001_gene3330	2.078e-228	717.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3F1C8@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD1_k127_7068655_9	671143.DAMO_1931	1.461e-36	143.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_7068655_4	671143.DAMO_1932	2.114e-80	282.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_7068655_0	671143.DAMO_1933	0.0	1399.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_7068655_12	439235.Dalk_0193	2.741e-18	86.0	COG0607@1|root,32YCZ@2|Bacteria,1N6NN@1224|Proteobacteria,42VWR@68525|delta/epsilon subdivisions,2WS4U@28221|Deltaproteobacteria,2MKU4@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD1_k127_7068655_5	338966.Ppro_1945	4.782e-74	260.0	COG1237@1|root,COG1237@2|Bacteria,1NK2I@1224|Proteobacteria,42QRA@68525|delta/epsilon subdivisions,2WN1V@28221|Deltaproteobacteria,43UE5@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_7068655_7	671143.DAMO_1046	6.931e-42	162.0	COG4747@1|root,COG4747@2|Bacteria,2NR4R@2323|unclassified Bacteria	2|Bacteria	S	ACT domain protein	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00570	R00220,R00996,R01513,R01773,R01775	RC00031,RC00087,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
HKD1_k127_7068655_11	1121468.AUBR01000008_gene2048	2.592e-24	110.0	COG5496@1|root,COG5496@2|Bacteria,1VAZJ@1239|Firmicutes,24MWR@186801|Clostridia,42GZU@68295|Thermoanaerobacterales	186801|Clostridia	S	THIoesterase	-	-	3.1.2.29	ko:K18700	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD1_k127_7068655_13	1031711.RSPO_c00381	2.137e-13	77.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2VW0M@28216|Betaproteobacteria,1K77D@119060|Burkholderiaceae	28216|Betaproteobacteria	DTZ	EF-hand domain pair	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD1_k127_7068655_10	1110502.TMO_0987	6.339e-36	142.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,2JSUH@204441|Rhodospirillales	204441|Rhodospirillales	M	17 kDa outer membrane surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Rick_17kDa_Anti
HKD1_k127_7068655_8	243233.MCA0364	6.924e-37	148.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
HKD1_k127_7068655_6	56780.SYN_02068	6.237e-54	204.0	COG1463@1|root,COG1463@2|Bacteria,1Q6ZU@1224|Proteobacteria,42RZ3@68525|delta/epsilon subdivisions,2WNF0@28221|Deltaproteobacteria,2MRII@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	MlaD protein	-	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
HKD1_k127_7068655_3	335543.Sfum_2415	5.802e-114	372.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,42NTG@68525|delta/epsilon subdivisions,2WKHW@28221|Deltaproteobacteria,2MQ9V@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_7068655_2	335543.Sfum_2414	3.119e-118	393.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,42MG3@68525|delta/epsilon subdivisions,2WKC7@28221|Deltaproteobacteria,2MQ7Q@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	COGs COG0767 ABC-type transport system involved in resistance to organic solvents permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_7068655_1	443143.GM18_4329	8.122e-216	699.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2WIVP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Large extracellular alpha-helical protein	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,Thiol-ester_cl
HKD1_k127_7089558_0	1123288.SOV_1c08590	4.022e-106	351.0	COG1073@1|root,COG1073@2|Bacteria,1TPW7@1239|Firmicutes,4H3KY@909932|Negativicutes	909932|Negativicutes	S	Dienelactone hydrolase family	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	DLH
HKD1_k127_7089558_2	243233.MCA1269	2.149e-25	107.0	COG3339@1|root,COG3339@2|Bacteria,1MZCY@1224|Proteobacteria,1SANY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD1_k127_7089558_1	498761.HM1_0223	1.624e-57	221.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_7097510_8	290512.Paes_0078	7.696e-25	106.0	COG2963@1|root,COG2963@2|Bacteria,1FFDM@1090|Chlorobi	1090|Chlorobi	L	PFAM transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD1_k127_7097510_4	288000.BBta_1540	3.39e-73	256.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,2TRX0@28211|Alphaproteobacteria,3JX1Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD1_k127_7097510_12	522306.CAP2UW1_0084	2.147e-17	85.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7097510_1	1366050.N234_27960	6.779e-174	557.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria,1K0XA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7097510_2	485913.Krac_7449	4.838e-143	475.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7097510_5	94624.Bpet1409	4.408e-64	222.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7097510_6	76114.p2A311	5.4e-33	133.0	COG1959@1|root,COG1959@2|Bacteria,1QVIX@1224|Proteobacteria,2WGT4@28216|Betaproteobacteria	2|Bacteria	K	Winged helix-turn helix	nsrR	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_28,Rrf2
HKD1_k127_7097510_10	420324.KI911932_gene324	1.677e-22	104.0	2EHAG@1|root,3394C@2|Bacteria,1NK4E@1224|Proteobacteria,2UJZB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Family of unknown function (DUF5372)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5372
HKD1_k127_7097510_11	1123228.AUIH01000088_gene549	1.129e-20	93.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
HKD1_k127_7097510_9	1173024.KI912148_gene4313	1.781e-24	107.0	COG1961@1|root,COG1961@2|Bacteria,1G266@1117|Cyanobacteria,1JKFH@1189|Stigonemataceae	1117|Cyanobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7097510_14	1121106.JQKB01000113_gene269	1.066e-07	53.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_7097510_0	1038869.AXAN01000047_gene4503	5.603e-208	697.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
HKD1_k127_7097510_3	118173.KB235914_gene2674	3.048e-106	388.0	COG3227@1|root,COG3227@2|Bacteria,1G3KW@1117|Cyanobacteria,1H7JS@1150|Oscillatoriales	1117|Cyanobacteria	E	Thermolysin metallopeptidase, alpha-helical domain	-	-	-	-	-	-	-	-	-	-	-	-	FTP,Peptidase_M4,Peptidase_M4_C
HKD1_k127_7097510_7	316067.Geob_3745	1.432e-32	149.0	COG0419@1|root,COG0419@2|Bacteria,1NQ8G@1224|Proteobacteria	1224|Proteobacteria	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7097510_13	472759.Nhal_0410	1.034e-07	66.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,1RMJ9@1236|Gammaproteobacteria,1WXTR@135613|Chromatiales	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 31 family	malZ	GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016758,GO:0033825,GO:0046527	2.4.1.161,3.2.1.20	ko:K01187,ko:K18820	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	CBM_20,DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_7101711_1	1379698.RBG1_1C00001G0724	4.582e-51	185.0	COG0691@1|root,COG0691@2|Bacteria,2NPFK@2323|unclassified Bacteria	2|Bacteria	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0070930,GO:0071704,GO:0097159,GO:1901363,GO:1901564	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_7101711_0	335543.Sfum_1184	1.384e-131	443.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1PFB9@1224|Proteobacteria,437WC@68525|delta/epsilon subdivisions,2X35Z@28221|Deltaproteobacteria,2MS2F@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7107254_0	338969.Rfer_3144	6.371e-66	229.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_7107254_1	1265505.ATUG01000002_gene2495	1.361e-56	208.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,2MM84@213118|Desulfobacterales	28221|Deltaproteobacteria	O	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
HKD1_k127_7107254_2	1265505.ATUG01000001_gene4392	4.69e-42	162.0	2C477@1|root,32RDF@2|Bacteria,1RKW1@1224|Proteobacteria,42SWN@68525|delta/epsilon subdivisions,2WP88@28221|Deltaproteobacteria,2MNB4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	DGC domain	-	-	-	-	-	-	-	-	-	-	-	-	DGC
HKD1_k127_7107254_4	1502851.FG93_05457	1.21e-18	91.0	COG0662@1|root,COG0662@2|Bacteria,1RICR@1224|Proteobacteria,2U9S9@28211|Alphaproteobacteria,3JZPA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7107254_5	1298867.AUES01000085_gene3659	1.158e-09	67.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7107254_3	113395.AXAI01000002_gene5216	5.728e-34	132.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7107258_3	1037409.BJ6T_61420	2.083e-41	160.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7107258_1	426117.M446_3978	7.477e-75	265.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2VCYB@28211|Alphaproteobacteria,1JXYK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7107258_2	189753.AXAS01000041_gene2534	1.682e-72	257.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7107258_0	189753.AXAS01000012_gene4337	7.278e-79	278.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7107258_4	113395.AXAI01000002_gene5216	5.728e-34	132.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7118183_0	304371.MCP_0600	2.61e-100	334.0	arCOG02575@1|root,arCOG02575@2157|Archaea,2XZ2N@28890|Euryarchaeota,2NAAE@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_7118183_1	234267.Acid_0100	6.244e-54	199.0	293RY@1|root,2ZR7G@2|Bacteria,3Y953@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7118183_7	278957.ABEA03000196_gene416	3.55e-05	51.0	COG1373@1|root,COG1373@2|Bacteria	2|Bacteria	V	ATPase (AAA superfamily	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HKD1_k127_7118183_4	1415166.NONO_c27930	7.912e-16	82.0	COG3631@1|root,COG3631@2|Bacteria,2HWPG@201174|Actinobacteria,4G56X@85025|Nocardiaceae	201174|Actinobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_7118183_5	765952.PUV_06400	5.671e-14	79.0	COG5485@1|root,COG5485@2|Bacteria	2|Bacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_7118183_2	1267535.KB906767_gene735	2.371e-42	168.0	COG1073@1|root,COG1073@2|Bacteria,3Y5TG@57723|Acidobacteria,2JNP5@204432|Acidobacteriia	204432|Acidobacteriia	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7118183_3	1331060.RLDS_22465	1.77e-25	117.0	COG0500@1|root,COG2226@2|Bacteria,1PVPS@1224|Proteobacteria,2TREE@28211|Alphaproteobacteria,2JZZE@204457|Sphingomonadales	204457|Sphingomonadales	Q	ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD1_k127_7124917_4	1232410.KI421412_gene83	1.22e-13	77.0	2CBYU@1|root,334FI@2|Bacteria,1NC3J@1224|Proteobacteria,42VH4@68525|delta/epsilon subdivisions,2WSCN@28221|Deltaproteobacteria,43STQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_5
HKD1_k127_7124917_0	378806.STAUR_1722	1.226e-255	796.0	COG0427@1|root,COG0427@2|Bacteria,1MUGE@1224|Proteobacteria,42MB6@68525|delta/epsilon subdivisions,2WJMI@28221|Deltaproteobacteria,2YXX3@29|Myxococcales	28221|Deltaproteobacteria	C	Acetyl-CoA hydrolase/transferase N-terminal domain	ato-2	-	2.8.3.18,3.1.2.1	ko:K01067,ko:K18118	ko00020,ko00620,ko00650,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00650,map01100,map01110,map01120,map01130,map01200	M00009,M00011	R00227,R10343	RC00004,RC00012,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1125	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_7124917_2	1499967.BAYZ01000013_gene6466	3.553e-90	310.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_7124917_5	196627.cg2569	3e-11	73.0	COG3090@1|root,COG3090@2|Bacteria,2IKZ5@201174|Actinobacteria,22N4F@1653|Corynebacteriaceae	201174|Actinobacteria	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_7124917_1	1499967.BAYZ01000013_gene6464	1.506e-157	516.0	COG1593@1|root,COG1593@2|Bacteria	2|Bacteria	G	mannitol 2-dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7124917_3	1120949.KB903298_gene5795	7.2e-26	115.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4DB58@85008|Micromonosporales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_7125950_6	880073.Calab_2443	2.203e-107	360.0	COG0604@1|root,COG0604@2|Bacteria,2NP5I@2323|unclassified Bacteria	2|Bacteria	C	PFAM Alcohol dehydrogenase, zinc-binding	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7125950_9	370438.PTH_1610	1.137e-99	340.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,260YG@186807|Peptococcaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512,PDZ
HKD1_k127_7125950_22	671143.DAMO_1207	1.16e-39	166.0	COG0558@1|root,COG0558@2|Bacteria,2NRJN@2323|unclassified Bacteria	2|Bacteria	I	CDP-alcohol phosphatidyltransferase	MA20_28295	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_7125950_4	671143.DAMO_1206	1.188e-121	402.0	COG2262@1|root,COG2262@2|Bacteria,2NNWI@2323|unclassified Bacteria	2|Bacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_7125950_13	671143.DAMO_1205	3.099e-66	236.0	COG0287@1|root,COG0287@2|Bacteria,2NPPI@2323|unclassified Bacteria	2|Bacteria	E	Prephenate dehydrogenase	aroA	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008977,GO:0009058,GO:0009072,GO:0009073,GO:0009095,GO:0009987,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0019438,GO:0019752,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046983,GO:0047794,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0070403,GO:0071704,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.3.1.12,1.3.1.43,2.5.1.19	ko:K00210,ko:K00220,ko:K00800,ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00022,M00025,M00040	R00732,R01728,R03460	RC00125,RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase,PDH
HKD1_k127_7125950_2	671143.DAMO_1203	1.123e-135	444.0	COG0079@1|root,COG0079@2|Bacteria,2NNZK@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_7125950_3	671143.DAMO_1202	9.088e-135	438.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,2NR2C@2323|unclassified Bacteria	2|Bacteria	E	Prephenate dehydratase	pheA	GO:0003674,GO:0003824,GO:0004106,GO:0004664,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006558,GO:0006570,GO:0006571,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009094,GO:0009095,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0017144,GO:0019438,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902221,GO:1902223	1.3.1.12,2.3.1.79,4.2.1.51,4.2.1.91,5.4.99.5	ko:K00661,ko:K01713,ko:K04092,ko:K04093,ko:K04516,ko:K04518,ko:K14170,ko:K14187	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715,R01728	RC00125,RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_2667	ACT,CM_2,PDT
HKD1_k127_7125950_11	671143.DAMO_1201	2.415e-68	244.0	COG1187@1|root,COG1187@2|Bacteria,2NPCM@2323|unclassified Bacteria	2|Bacteria	J	RNA pseudouridylate synthase	rsuA	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_7125950_17	671143.DAMO_1200	2.236e-54	198.0	COG1386@1|root,COG1386@2|Bacteria,2NPPM@2323|unclassified Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD1_k127_7125950_12	671143.DAMO_1199	1.534e-66	242.0	COG1354@1|root,COG1354@2|Bacteria,2NPM8@2323|unclassified Bacteria	2|Bacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD1_k127_7125950_26	867845.KI911784_gene2113	1.018e-12	78.0	COG1555@1|root,COG1555@2|Bacteria	2|Bacteria	L	photosystem II stabilization	comEA	-	2.4.1.21	ko:K00703,ko:K02237,ko:K02238	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00429,M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003,ko02044	3.A.11.1,3.A.11.2	GT5	-	HHH_3,PLDc_2,SLBB
HKD1_k127_7125950_0	671143.DAMO_1197	9.953e-192	622.0	COG0527@1|root,COG0527@2|Bacteria,2NNWK@2323|unclassified Bacteria	2|Bacteria	E	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	lysC	GO:0003674,GO:0003824,GO:0004072,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006553,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009507,GO:0009532,GO:0009536,GO:0009570,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019202,GO:0019752,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.3,2.7.2.4	ko:K00928,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_7125950_18	671143.DAMO_1196	2.984e-52	191.0	COG0344@1|root,COG0344@2|Bacteria,2NPME@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.3.1.15,2.7.9.2,3.5.1.104	ko:K01007,ko:K03977,ko:K08591,ko:K22278	ko00561,ko00564,ko00620,ko00680,ko00720,ko01100,ko01110,ko01120,ko01200,map00561,map00564,map00620,map00680,map00720,map01100,map01110,map01120,map01200	M00089,M00173,M00374	R00199,R00851,R09380	RC00002,RC00004,RC00015,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004,ko03009	-	-	-	G3P_acyltransf
HKD1_k127_7125950_14	671143.DAMO_1195	1.224e-60	214.0	COG0558@1|root,COG0558@2|Bacteria,2NPJ9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iIT341.HP1016	CDP-OH_P_transf
HKD1_k127_7125950_10	1232410.KI421414_gene2900	1.817e-95	319.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42MM0@68525|delta/epsilon subdivisions,2WKXZ@28221|Deltaproteobacteria,43RXV@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HKD1_k127_7125950_21	483219.LILAB_36320	6.597e-40	172.0	COG0457@1|root,COG0457@2|Bacteria,1R7RK@1224|Proteobacteria,42PPY@68525|delta/epsilon subdivisions,2WKX6@28221|Deltaproteobacteria,2YUCP@29|Myxococcales	28221|Deltaproteobacteria	NU	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19
HKD1_k127_7125950_20	671143.DAMO_1193	1.309e-46	177.0	COG0095@1|root,COG0095@2|Bacteria,2NPP1@2323|unclassified Bacteria	2|Bacteria	H	Biotin/lipoate A/B protein ligase family	lipM	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD1_k127_7125950_25	314278.NB231_05796	1.334e-22	100.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria,1WYUA@135613|Chromatiales	135613|Chromatiales	G	Phosphotransferase System	-	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD1_k127_7125950_24	404589.Anae109_0153	1.415e-34	136.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,42SST@68525|delta/epsilon subdivisions,2WPWN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM PTS system fructose subfamily IIA component	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
HKD1_k127_7125950_8	671143.DAMO_1192	5.278e-104	346.0	COG1660@1|root,COG1660@2|Bacteria,2NP9G@2323|unclassified Bacteria	2|Bacteria	S	P-loop ATPase protein family	rapZ	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0034641,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044464,GO:0046483,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:1901360,GO:1901363	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD1_k127_7125950_16	290397.Adeh_0146	1.687e-55	207.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,42P9W@68525|delta/epsilon subdivisions,2WK54@28221|Deltaproteobacteria,2YUU0@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD1_k127_7125950_15	671143.DAMO_1191	1.486e-57	209.0	COG1544@1|root,COG1544@2|Bacteria,2NPYS@2323|unclassified Bacteria	2|Bacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HKD1_k127_7125950_1	671143.DAMO_1190	4.696e-167	539.0	COG1508@1|root,COG1508@2|Bacteria,2NNZA@2323|unclassified Bacteria	2|Bacteria	K	RNA polymerase sigma-54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_7125950_5	671143.DAMO_1189	2.709e-109	359.0	COG1137@1|root,COG1137@2|Bacteria,2NNRT@2323|unclassified Bacteria	2|Bacteria	S	lipopolysaccharide transport protein B ATP-binding component of ABC superfamily	lptB	GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006869,GO:0008150,GO:0010876,GO:0015221,GO:0015399,GO:0015405,GO:0015437,GO:0015920,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0032991,GO:0033036,GO:0034040,GO:0042623,GO:0042626,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K01990,ko:K06861	ko02010,map02010	M00254,M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1,3.A.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7125950_23	671143.DAMO_1188	4.305e-39	152.0	COG1934@1|root,COG1934@2|Bacteria	2|Bacteria	S	lipopolysaccharide binding	lptA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065	OstA
HKD1_k127_7125950_28	484770.UFO1_4211	3.273e-07	61.0	COG3117@1|root,COG3117@2|Bacteria,1V9U6@1239|Firmicutes,4H4TV@909932|Negativicutes	909932|Negativicutes	S	Lipopolysaccharide-assembly, LptC-related	-	-	-	-	-	-	-	-	-	-	-	-	LptC
HKD1_k127_7125950_7	525904.Tter_0560	3.441e-105	361.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_7125950_19	671143.DAMO_1184	2.533e-50	183.0	COG1895@1|root,COG1895@2|Bacteria,2NRN4@2323|unclassified Bacteria	2|Bacteria	S	HEPN domain	-	-	-	-	-	-	-	-	-	-	-	-	HEPN
HKD1_k127_7125950_27	626887.J057_11236	1.994e-07	57.0	COG1708@1|root,COG1708@2|Bacteria,1RCAH@1224|Proteobacteria,1S3KC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2,NTP_transf_2
HKD1_k127_7149518_2	1268072.PSAB_23710	7.532e-42	161.0	COG1176@1|root,COG1176@2|Bacteria,1TRUC@1239|Firmicutes,4HABA@91061|Bacilli,26TSA@186822|Paenibacillaceae	91061|Bacilli	P	spermidine putrescine	cysT7	-	-	ko:K02054	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	BPD_transp_1
HKD1_k127_7149518_3	1268072.PSAB_23715	2.089e-14	76.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD1_k127_7149518_1	1268072.PSAB_23715	1.863e-49	187.0	COG4134@1|root,COG4134@2|Bacteria	2|Bacteria	S	Bacterial extracellular solute-binding protein	-	-	-	ko:K02055	ko02024,map02024	M00193	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11	-	-	SBP_bac_8
HKD1_k127_7149518_0	525904.Tter_0156	9.454e-128	422.0	COG0673@1|root,COG0673@2|Bacteria,2NQJC@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_7149518_4	1297569.MESS2_50050	5.512e-14	79.0	COG0673@1|root,COG0673@2|Bacteria,1QIQ6@1224|Proteobacteria,2U430@28211|Alphaproteobacteria,43R34@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_7150817_0	580340.Tlie_0365	1.1e-08	65.0	COG0457@1|root,COG0457@2|Bacteria	580340.Tlie_0365|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7150817_1	395495.Lcho_0109	1.159e-08	64.0	COG4191@1|root,COG4191@2|Bacteria,1R8JK@1224|Proteobacteria,2WEZZ@28216|Betaproteobacteria,1KNBN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_7153363_1	243231.GSU1784	9.073e-86	298.0	COG1459@1|root,COG1459@2|Bacteria,1N8FA@1224|Proteobacteria,42SJG@68525|delta/epsilon subdivisions,2WP9K@28221|Deltaproteobacteria,43T1M@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Type II secretion system (T2SS), protein F	pulF	-	-	ko:K02455,ko:K02653	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	T2SSF
HKD1_k127_7153363_0	243231.GSU1783	3.7e-180	583.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,42M51@68525|delta/epsilon subdivisions,2WTUB@28221|Deltaproteobacteria,43T1I@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	General secretory system II, protein E domain protein	pulE-1	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD1_k127_7153363_6	1232410.KI421421_gene3651	1.509e-11	77.0	COG4972@1|root,COG4972@2|Bacteria,1NVB9@1224|Proteobacteria,42ZK6@68525|delta/epsilon subdivisions,2WUWH@28221|Deltaproteobacteria,43UPI@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Pilus assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7153363_7	443143.GM18_1140	3.517e-11	74.0	COG3166@1|root,COG3166@2|Bacteria,1Q5NW@1224|Proteobacteria,431IV@68525|delta/epsilon subdivisions,2WWZG@28221|Deltaproteobacteria,43VK2@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	PFAM Fimbrial assembly family protein	pulN	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD1_k127_7153363_5	1232410.KI421421_gene3653	8.137e-12	74.0	2DXN2@1|root,345N1@2|Bacteria,1Q1PJ@1224|Proteobacteria,4319I@68525|delta/epsilon subdivisions,2WWAH@28221|Deltaproteobacteria,43VEM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pilus assembly protein, PilO	pulO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD1_k127_7153363_2	666681.M301_0466	3.727e-85	306.0	COG0457@1|root,COG4796@1|root,COG0457@2|Bacteria,COG4796@2|Bacteria,1QUY7@1224|Proteobacteria,2VJ8Z@28216|Betaproteobacteria,2KKT1@206350|Nitrosomonadales	28216|Betaproteobacteria	U	type II and III secretion system protein	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	STN,Secretin,Secretin_N
HKD1_k127_7153363_4	338963.Pcar_1678	3.912e-29	126.0	COG2165@1|root,COG2165@2|Bacteria,1RGZZ@1224|Proteobacteria,42T14@68525|delta/epsilon subdivisions,2WP8F@28221|Deltaproteobacteria,43SM2@69541|Desulfuromonadales	1224|Proteobacteria	NU	General secretion pathway	pulG	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD1_k127_7153363_3	933262.AXAM01000037_gene889	6.665e-36	142.0	COG2165@1|root,COG2165@2|Bacteria,1N1QJ@1224|Proteobacteria,42TXR@68525|delta/epsilon subdivisions,2WQP0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD1_k127_7153363_10	228410.NE1601	0.0001112	51.0	COG2165@1|root,COG2165@2|Bacteria,1MZ5I@1224|Proteobacteria,2VU7P@28216|Betaproteobacteria,3737A@32003|Nitrosomonadales	28216|Betaproteobacteria	NU	Type II secretory pathway, pseudopilin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7153363_9	292415.Tbd_1303	1.164e-06	51.0	COG2165@1|root,COG2165@2|Bacteria,1MZ5I@1224|Proteobacteria,2VU7P@28216|Betaproteobacteria	28216|Betaproteobacteria	NU	Type II secretory pathway, pseudopilin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7154220_0	748247.AZKH_1956	2.286e-268	831.0	COG5361@1|root,COG5361@2|Bacteria,1PJY5@1224|Proteobacteria,2W9FE@28216|Betaproteobacteria,2KZE5@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD1_k127_7154220_1	378806.STAUR_3774	1.234e-99	329.0	COG4690@1|root,COG4690@2|Bacteria,1R4YQ@1224|Proteobacteria,42NQZ@68525|delta/epsilon subdivisions,2WMGS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM peptidase U34 dipeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C69
HKD1_k127_7157112_10	1100720.ALKN01000045_gene230	0.0003352	48.0	2BKYI@1|root,32FF5@2|Bacteria,1MY1A@1224|Proteobacteria,2VRUQ@28216|Betaproteobacteria,4AERJ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_7157112_3	1217720.ALOX01000077_gene679	7.436e-59	214.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,2JPTU@204441|Rhodospirillales	204441|Rhodospirillales	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_7157112_2	1125973.JNLC01000011_gene579	2.799e-83	294.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,3JVY3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	MA20_23145	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_7157112_9	1205680.CAKO01000029_gene5096	9.852e-19	92.0	2C8H7@1|root,33157@2|Bacteria,1ND1D@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7157112_4	1502851.FG93_01418	1.494e-56	207.0	2C2X7@1|root,31WBU@2|Bacteria,1P2EC@1224|Proteobacteria,2UV16@28211|Alphaproteobacteria,3JWR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD1_k127_7157112_1	234267.Acid_6173	3.433e-171	542.0	COG1741@1|root,COG1741@2|Bacteria,3Y367@57723|Acidobacteria	57723|Acidobacteria	S	Pirin C-terminal cupin domain	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_7157112_8	926549.KI421517_gene429	2.3e-29	129.0	COG1082@1|root,COG1082@2|Bacteria,4NIG9@976|Bacteroidetes,47NIT@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_7157112_5	877455.Metbo_0347	8.204e-55	205.0	COG1408@1|root,arCOG01156@2157|Archaea,2Y1DW@28890|Euryarchaeota,23PMV@183925|Methanobacteria	183925|Methanobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_7157112_0	279714.FuraDRAFT_3442	2.789e-231	752.0	COG0744@1|root,COG0744@2|Bacteria,1NRPB@1224|Proteobacteria,2VJ7F@28216|Betaproteobacteria,2KSIX@206351|Neisseriales	206351|Neisseriales	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly
HKD1_k127_7157112_6	1121403.AUCV01000018_gene3201	6.2e-48	176.0	COG3467@1|root,COG3467@2|Bacteria,1N4RH@1224|Proteobacteria,42TKQ@68525|delta/epsilon subdivisions,2WQ06@28221|Deltaproteobacteria,2MKN9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD1_k127_7157112_7	278963.ATWD01000001_gene2829	2.516e-30	125.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_7175286_0	335543.Sfum_0673	0.0	1356.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_7175286_1	335543.Sfum_1464	5.015e-61	220.0	COG2202@1|root,COG3829@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42MEA@68525|delta/epsilon subdivisions,2WIW6@28221|Deltaproteobacteria,2MR33@213462|Syntrophobacterales	28221|Deltaproteobacteria	KT	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HTH_8,PAS_3,PAS_4,Sigma54_activat
HKD1_k127_7182409_3	697282.Mettu_0209	2.175e-89	317.0	COG3209@1|root,COG4447@1|root,COG3209@2|Bacteria,COG4447@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,1XGAS@135618|Methylococcales	135618|Methylococcales	M	TIGRFAM RHS repeat-associated core domain	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_7182409_6	1122221.JHVI01000002_gene787	9.884e-19	101.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
HKD1_k127_7182409_2	671143.DAMO_2491	1.882e-109	360.0	COG1028@1|root,COG1028@2|Bacteria,2NQBD@2323|unclassified Bacteria	2|Bacteria	IQ	NAD(P)H binding domain of trans-2-enoyl-CoA reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_7182409_5	1123371.ATXH01000018_gene1376	1.141e-58	218.0	COG1028@1|root,COG1028@2|Bacteria,2GH4K@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_7182409_1	1499967.BAYZ01000159_gene493	4.476e-123	405.0	COG3958@1|root,COG3958@2|Bacteria,2NQFH@2323|unclassified Bacteria	2|Bacteria	G	Transketolase, pyrimidine binding domain	dxs_2	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_7182409_0	1499967.BAYZ01000159_gene494	1.33e-142	465.0	COG3959@1|root,COG3959@2|Bacteria,2NP12@2323|unclassified Bacteria	2|Bacteria	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_7182409_4	562970.Btus_0581	3.55e-74	262.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,2788T@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K13767	ko00071,ko00362,ko01100,ko01120,ko01212,map00071,map00362,map01100,map01120,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_7182409_8	1387312.BAUS01000004_gene1399	0.000638	51.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2VM1S@28216|Betaproteobacteria,2KNE2@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD1_k127_7191065_15	1382359.JIAL01000001_gene2052	1.002e-59	207.0	COG1064@1|root,COG1064@2|Bacteria,3Y33B@57723|Acidobacteria,2JI1P@204432|Acidobacteriia	204432|Acidobacteriia	S	Zinc-binding dehydrogenase	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7191065_20	404380.Gbem_0067	1.004e-31	136.0	COG1143@1|root,COG3260@1|root,COG1143@2|Bacteria,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,42SGB@68525|delta/epsilon subdivisions,2WPYA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_7191065_19	351160.RCIX476	2.609e-35	142.0	COG0437@1|root,arCOG01500@2157|Archaea,2Y7H8@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4,Fer4_11,Fer4_3,Fer4_4,Fer4_6
HKD1_k127_7191065_23	338966.Ppro_0594	8.568e-10	70.0	COG0852@1|root,COG0852@2|Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_7191065_16	1094980.Mpsy_1377	8.013e-58	211.0	COG2048@1|root,arCOG00338@2157|Archaea,2XTWJ@28890|Euryarchaeota,2N93S@224756|Methanomicrobia	224756|Methanomicrobia	C	CoB--CoM heterodisulfide reductase subunit B	hdrB-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
HKD1_k127_7191065_10	309798.COPRO5265_0933	7.597e-86	302.0	COG3261@1|root,COG3261@2|Bacteria,1VZGX@1239|Firmicutes,248UJ@186801|Clostridia,42EKZ@68295|Thermoanaerobacterales	186801|Clostridia	C	Nickel-dependent hydrogenase	-	-	-	ko:K15830	-	-	-	-	ko00000	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_7191065_7	344747.PM8797T_25801	4.164e-128	427.0	COG1249@1|root,COG1249@2|Bacteria,2IX5H@203682|Planctomycetes	203682|Planctomycetes	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex dihydrolipoamide dehydrogenase (E3)	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_7191065_9	1303518.CCALI_02780	1.057e-97	329.0	COG0320@1|root,COG0320@2|Bacteria	2|Bacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009987,GO:0010467,GO:0016053,GO:0016740,GO:0016782,GO:0016783,GO:0016992,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019538,GO:0019752,GO:0032787,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0046483,GO:0051186,GO:0051188,GO:0051604,GO:0070283,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Lip_prot_lig_C,Radical_SAM
HKD1_k127_7191065_4	671143.DAMO_1503	4.37e-213	666.0	COG0436@1|root,COG0436@2|Bacteria,2NQG2@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class I and II	yfdZ	GO:0003674,GO:0003824,GO:0004021,GO:0006082,GO:0006090,GO:0006520,GO:0006522,GO:0006523,GO:0006807,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009058,GO:0009078,GO:0009079,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019272,GO:0019752,GO:0030632,GO:0032787,GO:0042851,GO:0042852,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046144,GO:0046145,GO:0046394,GO:0046416,GO:0046436,GO:0046437,GO:0047635,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.83	ko:K10206,ko:K14261	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEcSMS35_1347.EcSMS35_2531,iSBO_1134.SBO_2405	Aminotran_1_2
HKD1_k127_7191065_3	671143.DAMO_1501	6.179e-222	702.0	COG0034@1|root,COG0034@2|Bacteria,2NNSY@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009507,GO:0009536,GO:0040007,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iSB619.SA_RS05225	GATase_6,GATase_7,Pribosyltran
HKD1_k127_7191065_11	373903.Hore_03340	1.78e-74	268.0	COG1653@1|root,COG1653@2|Bacteria,1UEZ3@1239|Firmicutes,24ATD@186801|Clostridia	186801|Clostridia	G	solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_7191065_14	373903.Hore_03300	4.04e-61	223.0	COG1175@1|root,COG1175@2|Bacteria,1UYKA@1239|Firmicutes,24FGT@186801|Clostridia	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_7191065_12	926550.CLDAP_24740	1.874e-74	260.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_7191065_24	1121106.JQKB01000054_gene4475	2.94e-08	63.0	COG0835@1|root,COG0835@2|Bacteria,1RAH1@1224|Proteobacteria,2TSA3@28211|Alphaproteobacteria,2JPQS@204441|Rhodospirillales	204441|Rhodospirillales	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD1_k127_7191065_22	747365.Thena_0027	7.49e-19	93.0	COG0835@1|root,COG0835@2|Bacteria,1V4HH@1239|Firmicutes,24JV4@186801|Clostridia,42GKD@68295|Thermoanaerobacterales	186801|Clostridia	NT	PFAM CheW domain protein	cheW1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD1_k127_7191065_18	243231.GSU2046	2.194e-35	154.0	COG0745@1|root,COG0745@2|Bacteria,1NER5@1224|Proteobacteria,42VHC@68525|delta/epsilon subdivisions,2WSGQ@28221|Deltaproteobacteria,43UMT@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_7191065_0	1125863.JAFN01000001_gene800	0.0	1079.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,42MPZ@68525|delta/epsilon subdivisions,2WIR9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	GO:0003674,GO:0003824,GO:0004812,GO:0004832,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006438,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_7191065_17	635013.TherJR_0220	5.246e-55	202.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,260CI@186807|Peptococcaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_7191065_8	671143.DAMO_0664	4.138e-112	368.0	COG1521@1|root,COG1521@2|Bacteria,2NP3Z@2323|unclassified Bacteria	2|Bacteria	K	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1986	Pan_kinase
HKD1_k127_7191065_6	1173028.ANKO01000017_gene246	1.315e-142	480.0	COG0309@1|root,COG0309@2|Bacteria,1G1Z7@1117|Cyanobacteria,1H82T@1150|Oscillatoriales	1117|Cyanobacteria	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_7191065_5	1173028.ANKO01000017_gene249	7.101e-182	578.0	COG0409@1|root,COG0409@2|Bacteria,1G0NJ@1117|Cyanobacteria,1H8DU@1150|Oscillatoriales	1117|Cyanobacteria	O	hydrogenase expression formation protein	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD1_k127_7191065_21	65393.PCC7424_3681	2.374e-26	114.0	COG0298@1|root,COG0298@2|Bacteria,1G9FZ@1117|Cyanobacteria,3KIER@43988|Cyanothece	1117|Cyanobacteria	O	PFAM hydrogenase expression formation protein (HUPF HYPC)	hypC	-	-	ko:K04653	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD1_k127_7191065_1	1173028.ANKO01000017_gene228	1.979e-287	912.0	COG0068@1|root,COG0068@2|Bacteria,1G063@1117|Cyanobacteria,1H71F@1150|Oscillatoriales	1117|Cyanobacteria	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD1_k127_7191065_13	891968.Anamo_1767	5.998e-72	250.0	COG0846@1|root,COG0846@2|Bacteria,3TA0W@508458|Synergistetes	508458|Synergistetes	K	PFAM Silent information regulator protein Sir2	-	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD1_k127_7191065_2	243231.GSU1564	3.967e-250	782.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,42KZZ@68525|delta/epsilon subdivisions,2WJWV@28221|Deltaproteobacteria,43SQT@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	PFAM Glu Leu Phe Val dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH,ELFV_dehydrog
HKD1_k127_7202074_0	452637.Oter_3676	1.926e-73	263.0	COG2048@1|root,COG2048@2|Bacteria	2|Bacteria	C	Heterodisulfide reductase, subunit B	hdrB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
HKD1_k127_7202074_2	880073.Calab_3048	1.212e-54	199.0	COG1150@1|root,COG1150@2|Bacteria,2NQ2K@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
HKD1_k127_7202074_1	1265505.ATUG01000002_gene1615	3.708e-69	243.0	COG0247@1|root,COG1150@1|root,COG0247@2|Bacteria,COG1150@2|Bacteria,1MUMH@1224|Proteobacteria,42N5J@68525|delta/epsilon subdivisions,2WJ6B@28221|Deltaproteobacteria,2MJHX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD1_k127_7203645_0	107635.AZUO01000005_gene4217	8.82e-98	334.0	COG3464@1|root,COG3464@2|Bacteria,1QW5Z@1224|Proteobacteria,2U3N2@28211|Alphaproteobacteria,3708E@31993|Methylocystaceae	28211|Alphaproteobacteria	L	Transposase IS66 family	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_7203645_1	1131813.AQVT01000001_gene2130	6.175e-59	209.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,1JUY6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_29,HTH_32
HKD1_k127_7203645_2	426117.M446_2794	9.947e-37	153.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria,1JUY6@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_29,HTH_32
HKD1_k127_7205211_6	383372.Rcas_2729	0.0008077	46.0	2A4K7@1|root,30T6V@2|Bacteria,2GB43@200795|Chloroflexi,377VP@32061|Chloroflexia	32061|Chloroflexia	S	Ribosomally synthesized peptide prototyped by Frankia Franean1_4349.	-	-	-	-	-	-	-	-	-	-	-	-	Frankia_peptide
HKD1_k127_7205211_4	330214.NIDE0866	1.169e-52	201.0	COG2854@1|root,COG2854@2|Bacteria,3J13Z@40117|Nitrospirae	40117|Nitrospirae	Q	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD1_k127_7205211_3	330214.NIDE0865	4.123e-59	209.0	COG1463@1|root,COG1463@2|Bacteria,3J191@40117|Nitrospirae	40117|Nitrospirae	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_7205211_1	330214.NIDE0864	8.76e-90	302.0	COG1127@1|root,COG1127@2|Bacteria,3J0J2@40117|Nitrospirae	40117|Nitrospirae	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_7205211_0	330214.NIDE0863	2.905e-102	339.0	COG0767@1|root,COG0767@2|Bacteria,3J0I7@40117|Nitrospirae	40117|Nitrospirae	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_7205211_5	1528098.NOVO_05845	4.049e-38	149.0	COG4520@1|root,COG4520@2|Bacteria,1N0YF@1224|Proteobacteria,2UA8D@28211|Alphaproteobacteria,47FH4@766|Rickettsiales	766|Rickettsiales	M	COG4520 Surface antigen	omp	-	-	-	-	-	-	-	-	-	-	-	17kDa_Anti_2,Rick_17kDa_Anti
HKD1_k127_7205211_2	671143.DAMO_2097	4.481e-60	219.0	COG2853@1|root,COG2853@2|Bacteria,2NRQC@2323|unclassified Bacteria	2|Bacteria	M	MlaA lipoprotein	vacJ	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD1_k127_7206887_10	644282.Deba_0053	1.042e-10	70.0	COG2202@1|root,COG2202@2|Bacteria,1N47P@1224|Proteobacteria,42W9J@68525|delta/epsilon subdivisions,2WSBM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	PAS_3
HKD1_k127_7206887_8	316274.Haur_4357	1.227e-26	119.0	COG3707@1|root,COG3707@2|Bacteria,2G6CD@200795|Chloroflexi,376C7@32061|Chloroflexia	32061|Chloroflexia	T	PFAM response regulator receiver	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HKD1_k127_7206887_4	768710.DesyoDRAFT_1526	9.599e-65	229.0	COG2197@1|root,COG2197@2|Bacteria,1TSBV@1239|Firmicutes,25BWE@186801|Clostridia	186801|Clostridia	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7206887_6	768710.DesyoDRAFT_1525	3.315e-43	183.0	COG4585@1|root,COG5000@1|root,COG4585@2|Bacteria,COG5000@2|Bacteria,1TQI3@1239|Firmicutes,249R9@186801|Clostridia,2644X@186807|Peptococcaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07777	ko02020,map02020	M00478	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA_3,sCache_3_2
HKD1_k127_7206887_5	118163.Ple7327_0190	7.26e-53	214.0	COG2202@1|root,COG3829@1|root,COG4251@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,1G0A1@1117|Cyanobacteria,3VHNF@52604|Pleurocapsales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_7206887_0	1051632.TPY_0253	2.471e-219	696.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia	186801|Clostridia	C	L-lactate permease	glcA	-	-	ko:K02550,ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14,2.A.14.1.2	-	-	Lactate_perm
HKD1_k127_7206887_1	1040989.AWZU01000001_gene5946	2.461e-105	364.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TVPU@28211|Alphaproteobacteria,3JSFR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	lactate/malate dehydrogenase, alpha/beta C-terminal domain	ldh	-	1.1.1.27	ko:K00016	ko00010,ko00270,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko04922,map00010,map00270,map00620,map00640,map01100,map01110,map01120,map01130,map04922	-	R00703,R01000,R03104	RC00031,RC00044	ko00000,ko00001,ko01000,ko04147	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_7206887_2	404380.Gbem_2600	3.061e-102	340.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,42YHH@68525|delta/epsilon subdivisions,2WU2V@28221|Deltaproteobacteria,43S20@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_7206887_3	189753.AXAS01000003_gene4860	1.129e-78	267.0	COG2514@1|root,COG2514@2|Bacteria,1RBC7@1224|Proteobacteria,2U5JP@28211|Alphaproteobacteria,3JR7C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	MA20_22790	-	1.13.11.2	ko:K07104	ko00361,ko00362,ko00622,ko00643,ko01100,ko01120,ko01220,map00361,map00362,map00622,map00643,map01100,map01120,map01220	M00569	R00816,R04089,R05295,R05404,R05406,R07795	RC00387,RC00643,RC01075,RC01364,RC01914	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase
HKD1_k127_7206887_9	671143.DAMO_2648	1.473e-14	82.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	ko:K03286,ko:K12976,ko:K16079	-	-	-	-	ko00000,ko01000,ko01005,ko02000	1.B.4.2.1,1.B.6	-	-	CBP_BcsS,DUF3943,OMP_b-brl,PagL
HKD1_k127_7206887_7	517418.Ctha_0741	1.414e-38	149.0	COG2010@1|root,COG2010@2|Bacteria,1FEAI@1090|Chlorobi	1090|Chlorobi	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HKD1_k127_720935_0	1168059.KB899087_gene1208	7.201e-12	69.0	COG4626@1|root,COG4626@2|Bacteria,1MW7K@1224|Proteobacteria,2TSDW@28211|Alphaproteobacteria,3EYCS@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Phage Terminase	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_1
HKD1_k127_7210437_2	671143.DAMO_2848	1.427e-120	393.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2NNX4@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	GO:0003674,GO:0003824,GO:0003938,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009314,GO:0009411,GO:0009416,GO:0009628,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0050896,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAPECO1_1312.APECO1_4018,iECABU_c1320.ECABU_c28100,iECP_1309.ECP_2510,iECSF_1327.ECSF_2349,iUTI89_1310.UTI89_C2826,ic_1306.c3027	CBS,IMPDH,NMO
HKD1_k127_7210437_1	671143.DAMO_2847	7.362e-155	494.0	COG0180@1|root,COG0180@2|Bacteria,2NNQX@2323|unclassified Bacteria	2|Bacteria	J	tRNA synthetases class I (W and Y)	trpS	GO:0003674,GO:0003824,GO:0004812,GO:0004830,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006436,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD1_k127_7210437_5	671143.DAMO_2846	6.171e-59	211.0	COG1994@1|root,COG1994@2|Bacteria,2NPQP@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD1_k127_7210437_0	1232410.KI421414_gene2893	1.807e-246	789.0	COG0517@1|root,COG0617@1|root,COG0618@1|root,COG0517@2|Bacteria,COG0617@2|Bacteria,COG0618@2|Bacteria,1MU2X@1224|Proteobacteria,42MJJ@68525|delta/epsilon subdivisions,2WJBN@28221|Deltaproteobacteria,43U0J@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	CBS domain containing protein	ccaA	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	CBS,DHH,DHHA1,PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_7210437_6	627192.SLG_09170	1.107e-13	81.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,2K0P0@204457|Sphingomonadales	204457|Sphingomonadales	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	HAD_2,Virul_fac_BrkB
HKD1_k127_7210437_7	264732.Moth_1682	1.856e-06	54.0	COG5416@1|root,COG5416@2|Bacteria,1VK4W@1239|Firmicutes,24RJX@186801|Clostridia,42HFD@68295|Thermoanaerobacterales	186801|Clostridia	S	Lipopolysaccharide assembly protein A domain	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
HKD1_k127_7210437_4	290397.Adeh_3668	1.21e-89	318.0	COG0475@1|root,COG0475@2|Bacteria,1RB9F@1224|Proteobacteria,42UIK@68525|delta/epsilon subdivisions,2X5D2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_7210437_3	357808.RoseRS_1484	5.424e-112	367.0	COG0604@1|root,COG0604@2|Bacteria,2G6KH@200795|Chloroflexi,3763V@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7211844_2	1449080.JQMV01000003_gene428	0.0002615	48.0	COG0013@1|root,COG0013@2|Bacteria,1WJC8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_7211844_1	204669.Acid345_0729	1.32e-138	462.0	COG0167@1|root,COG0167@2|Bacteria,3Y464@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_7211844_0	204669.Acid345_0730	6.952e-190	599.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,3Y415@57723|Acidobacteria,2JM30@204432|Acidobacteriia	204432|Acidobacteriia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_7253193_0	886293.Sinac_0712	7.333e-115	374.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	TrfA
HKD1_k127_7253193_2	743299.Acife_0757	4.034e-76	261.0	COG4974@1|root,COG4974@2|Bacteria,1RKT8@1224|Proteobacteria,1S7JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
HKD1_k127_7253193_1	1121378.KB899745_gene3737	8.058e-85	286.0	COG0582@1|root,COG0582@2|Bacteria,1WM1D@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Phage integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
HKD1_k127_7276751_1	395493.BegalDRAFT_0662	3.763e-247	808.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,1RPC6@1236|Gammaproteobacteria,45ZUQ@72273|Thiotrichales	72273|Thiotrichales	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit contributes ATPase, 3'-5' helicase, exonuclease activity and loads RecA onto ssDNA	recB	-	3.1.11.5	ko:K03582	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_7276751_0	269799.Gmet_1894	8.465e-260	835.0	COG1330@1|root,COG1330@2|Bacteria,1MWTI@1224|Proteobacteria,42N6G@68525|delta/epsilon subdivisions,2WJ4Q@28221|Deltaproteobacteria,43T50@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity	recC	-	3.1.11.5	ko:K03583	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_V_gamma
HKD1_k127_7276751_12	1265505.ATUG01000001_gene3898	3.906e-97	333.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42MMF@68525|delta/epsilon subdivisions,2WJ1F@28221|Deltaproteobacteria,2MHQX@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG,Fer4_8
HKD1_k127_7276751_13	1382306.JNIM01000001_gene1615	3.181e-83	295.0	COG0277@1|root,COG0277@2|Bacteria,2G6FW@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	-	ko:K11472	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_7276751_3	1382306.JNIM01000001_gene1617	1.056e-165	533.0	COG0277@1|root,COG0277@2|Bacteria,2G5TM@200795|Chloroflexi	200795|Chloroflexi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_7276751_10	264732.Moth_1000	4.738e-104	352.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia,42FN6@68295|Thermoanaerobacterales	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_7276751_21	909663.KI867150_gene1521	1.545e-33	139.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Acetyltransf_3,NUDIX,NUDIX_4
HKD1_k127_7276751_2	314230.DSM3645_05780	1.429e-175	569.0	COG1902@1|root,COG1902@2|Bacteria,2IXBM@203682|Planctomycetes	203682|Planctomycetes	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD1_k127_7276751_18	1121403.AUCV01000001_gene718	1.58e-64	228.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2MKFJ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_7276751_20	1300345.LF41_1764	2.618e-44	170.0	COG5400@1|root,COG5400@2|Bacteria,1NDMP@1224|Proteobacteria,1SFZS@1236|Gammaproteobacteria,1XD1Z@135614|Xanthomonadales	135614|Xanthomonadales	S	conserved protein UCP033924	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7276751_14	247490.KSU1_C1409	3.307e-81	283.0	COG1216@1|root,COG1216@2|Bacteria,2J0X8@203682|Planctomycetes	203682|Planctomycetes	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_7276751_8	247490.KSU1_C1408	2.911e-111	378.0	COG1233@1|root,COG1233@2|Bacteria,2IXJU@203682|Planctomycetes	203682|Planctomycetes	C	COG1233 Phytoene dehydrogenase and related	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD1_k127_7276751_4	247490.KSU1_C1407	1.528e-155	523.0	COG4258@1|root,COG4258@2|Bacteria,2IYH7@203682|Planctomycetes	203682|Planctomycetes	S	MMPL family	-	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD1_k127_7276751_15	247490.KSU1_C1406	1.185e-80	278.0	COG0500@1|root,COG2226@2|Bacteria,2J51A@203682|Planctomycetes	203682|Planctomycetes	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_7276751_22	1122599.AUGR01000001_gene435	1.438e-27	120.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1XJ86@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_7276751_23	247490.KSU1_C1404	7.597e-18	86.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_7276751_17	997346.HMPREF9374_0896	3.24e-68	239.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,4HAA6@91061|Bacilli,27BBK@186824|Thermoactinomycetaceae	91061|Bacilli	IQ	KR domain	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iYO844.BSU15910	adh_short_C2
HKD1_k127_7276751_5	247490.KSU1_C1403	3.329e-135	444.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_7276751_7	247490.KSU1_C1402	5.226e-125	417.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	-	-	-	ko:K07011,ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD1_k127_7276751_6	247490.KSU1_C1401	1.423e-129	439.0	COG1541@1|root,COG1541@2|Bacteria,2IXI4@203682|Planctomycetes	203682|Planctomycetes	H	COG1541 Coenzyme F390 synthetase	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_7276751_25	1463841.JOIR01000002_gene5998	3.266e-10	72.0	COG0304@1|root,COG0304@2|Bacteria,2IAIT@201174|Actinobacteria	201174|Actinobacteria	IQ	Beta-ketoacyl synthase, N-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ketoacyl-synt
HKD1_k127_7276751_11	247490.KSU1_C1399	6.02e-104	351.0	COG0304@1|root,COG0304@2|Bacteria	2|Bacteria	I	3-oxoacyl-[acyl-carrier-protein] synthase activity	sppA	-	2.3.1.179,2.3.1.235,2.3.1.260	ko:K05551,ko:K09458,ko:K14667	ko00061,ko00253,ko00780,ko01056,ko01100,ko01130,ko01212,map00061,map00253,map00780,map01056,map01100,map01130,map01212	M00083,M00572,M00778	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R06635,R06637,R06641,R06643,R06644,R06645,R07762,R09258,R09259,R10115,R10119,R10960,R11516	RC00004,RC00039,RC02545,RC02728,RC02729,RC02888,RC02931,RC02932,RC02947	ko00000,ko00001,ko00002,ko01000,ko01004,ko01008	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_7276751_24	1280946.HY29_16315	3.359e-15	87.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,43W9H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	GO:0003674,GO:0003824,GO:0004312,GO:0004315,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_7276751_9	247490.KSU1_C1396	1.596e-106	357.0	COG0304@1|root,COG0304@2|Bacteria	2|Bacteria	I	3-oxoacyl-[acyl-carrier-protein] synthase activity	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_7299846_24	649638.Trad_0184	0.0005221	45.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_7299846_22	273063.STK_17850	2.096e-11	68.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_7299846_6	189753.AXAS01000041_gene2534	2.695e-88	310.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7299846_1	1502851.FG93_00182	1.021e-274	884.0	COG0642@1|root,COG2203@1|root,COG5002@1|root,COG2203@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria,2TX3Q@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,Response_reg,dCache_1
HKD1_k127_7299846_20	1121904.ARBP01000006_gene3876	1.22e-28	135.0	COG0642@1|root,COG2205@2|Bacteria,4NGAS@976|Bacteroidetes,47PB2@768503|Cytophagia	976|Bacteroidetes	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,TPR_8
HKD1_k127_7299846_7	1386089.N865_04180	1.239e-82	304.0	COG0642@1|root,COG2205@2|Bacteria,2I2M2@201174|Actinobacteria,4FFYD@85021|Intrasporangiaceae	201174|Actinobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HKD1_k127_7299846_17	247490.KSU1_C0339	9.735e-34	136.0	COG0745@1|root,COG0745@2|Bacteria,2J0FN@203682|Planctomycetes	203682|Planctomycetes	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_7299846_18	760568.Desku_2034	5.784e-32	140.0	COG0745@1|root,COG3437@1|root,COG0745@2|Bacteria,COG3437@2|Bacteria,1UQJH@1239|Firmicutes,248UM@186801|Clostridia	186801|Clostridia	T	Response regulator containing a CheY-like receiver domain and an HD-GYP domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	DUF3369,HATPase_c,HD,HD_5,Response_reg
HKD1_k127_7299846_16	1117379.BABA_06541	2.895e-37	162.0	COG0265@1|root,COG0265@2|Bacteria,1UYZJ@1239|Firmicutes,4HFHN@91061|Bacilli,1ZEM1@1386|Bacillus	91061|Bacilli	O	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_7299846_21	1336243.JAEA01000006_gene422	1.302e-21	111.0	COG2461@1|root,COG3829@1|root,COG3920@1|root,COG2461@2|Bacteria,COG3829@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2U3NH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	HWE histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS,PAS_4
HKD1_k127_7299846_5	1379698.RBG1_1C00001G1421	5.995e-99	352.0	COG4191@1|root,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,MASE3,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_7299846_12	1121413.JMKT01000012_gene678	6.605e-58	207.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	ymfD	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD1_k127_7299846_0	335543.Sfum_3516	6.801e-283	884.0	COG0008@1|root,COG0008@2|Bacteria,1MUC8@1224|Proteobacteria,42MAX@68525|delta/epsilon subdivisions,2WJ5B@28221|Deltaproteobacteria,2MQTV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	GatB_Yqey,tRNA-synt_1c,tRNA-synt_1c_C
HKD1_k127_7299846_8	742733.HMPREF9469_01914	1.814e-79	273.0	COG3836@1|root,COG3836@2|Bacteria,1UZZG@1239|Firmicutes,24DTX@186801|Clostridia,222QV@1506553|Lachnoclostridium	186801|Clostridia	C	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.2.52,4.1.2.53	ko:K02510,ko:K12660	ko00051,ko00350,ko01120,map00051,map00350,map01120	-	R01645,R01647,R02261	RC00307,RC00435,RC00572,RC00574,RC03057	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_7299846_9	997346.HMPREF9374_1164	4.741e-67	240.0	COG0613@1|root,COG0613@2|Bacteria,1TPI5@1239|Firmicutes,4HB6B@91061|Bacilli,27B49@186824|Thermoactinomycetaceae	91061|Bacilli	S	metal-dependent phosphoesterases (PHP family)	php	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD1_k127_7299846_4	562970.Btus_0655	3.522e-115	381.0	COG1522@1|root,COG1522@2|Bacteria,1V6TH@1239|Firmicutes,4HAAQ@91061|Bacilli	91061|Bacilli	K	Transcriptional regulator (AsnC family)	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HKD1_k127_7299846_13	671143.DAMO_1592	2.467e-53	199.0	COG1131@1|root,COG1131@2|Bacteria,2NR7X@2323|unclassified Bacteria	2|Bacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	ccmA	-	3.6.3.41	ko:K01990,ko:K02193	ko02010,map02010	M00254,M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.107	-	-	ABC_tran
HKD1_k127_7299846_14	234267.Acid_4237	8.055e-46	173.0	COG2386@1|root,COG2386@2|Bacteria,3Y3G1@57723|Acidobacteria	57723|Acidobacteria	O	PFAM Cytochrome c-type biogenesis protein CcmB	-	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD1_k127_7299846_11	671143.DAMO_1590	1.26e-65	241.0	COG0755@1|root,COG0755@2|Bacteria,2NPG8@2323|unclassified Bacteria	2|Bacteria	O	Cytochrome C assembly protein	ccmC	GO:0001539,GO:0002048,GO:0002049,GO:0003674,GO:0003824,GO:0004096,GO:0004601,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006518,GO:0006629,GO:0006643,GO:0006664,GO:0006807,GO:0006810,GO:0006928,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009237,GO:0009247,GO:0009636,GO:0009987,GO:0015886,GO:0016020,GO:0016021,GO:0016209,GO:0016491,GO:0016684,GO:0019184,GO:0019290,GO:0019748,GO:0031224,GO:0031226,GO:0034641,GO:0040011,GO:0042221,GO:0043043,GO:0043107,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044425,GO:0044459,GO:0044464,GO:0044550,GO:0046467,GO:0048870,GO:0050896,GO:0051179,GO:0051181,GO:0051186,GO:0051188,GO:0051234,GO:0051674,GO:0051716,GO:0055114,GO:0070887,GO:0071702,GO:0071704,GO:0071705,GO:0071944,GO:0071973,GO:0071975,GO:0071977,GO:0071978,GO:0097237,GO:0097588,GO:0098754,GO:0098869,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576,GO:1901678,GO:1903509,GO:1990748	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	iECDH1ME8569_1439.ECDH1ME8569_2134,iSFV_1184.SFV_2275,iSFxv_1172.SFxv_2517,iUTI89_1310.UTI89_C2477,ic_1306.c2736	Cytochrom_C_asm
HKD1_k127_7299846_15	671143.DAMO_1589	4.401e-38	149.0	COG2332@1|root,COG2332@2|Bacteria	2|Bacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD1_k127_7299846_2	871963.Desdi_1145	3.951e-174	569.0	COG1138@1|root,COG1138@2|Bacteria,1UH6S@1239|Firmicutes,24BV3@186801|Clostridia,26427@186807|Peptococcaceae	186801|Clostridia	O	PFAM Cytochrome C assembly protein	-	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD1_k127_7299846_10	671143.DAMO_1587	9.775e-66	230.0	COG0526@1|root,COG0526@2|Bacteria,2NPYK@2323|unclassified Bacteria	2|Bacteria	O	Thioredoxin-like	dsbE	-	-	ko:K02199,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	AhpC-TSA,Redoxin,Thioredoxin
HKD1_k127_7299846_19	671143.DAMO_1586	1.032e-29	124.0	COG3088@1|root,COG3088@2|Bacteria,2NRBD@2323|unclassified Bacteria	2|Bacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02198,ko:K02200	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmH
HKD1_k127_7299846_3	1303518.CCALI_00141	6.759e-133	434.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnE	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.120,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784,ko:K18285	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396,R10667	RC00021,RC01381,RC02329,RC03002,RC03007,RC03234	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_7309079_5	391615.ABSJ01000004_gene644	3.474e-17	83.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1J4W8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_7309079_2	671143.DAMO_2784	1.182e-152	488.0	COG0451@1|root,COG0451@2|Bacteria,2NP15@2323|unclassified Bacteria	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	rfbB	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_7309079_3	671143.DAMO_0267	1.193e-109	363.0	COG2870@1|root,COG2870@2|Bacteria,2NNUT@2323|unclassified Bacteria	2|Bacteria	M	pfkB family carbohydrate kinase	rfaE	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_like,PfkB
HKD1_k127_7309079_4	269799.Gmet_1275	4.396e-77	265.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,42PTX@68525|delta/epsilon subdivisions,2WMQW@28221|Deltaproteobacteria,43T2I@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD1_k127_7309079_0	671143.DAMO_0268	8.231e-284	878.0	COG0504@1|root,COG0504@2|Bacteria,2NNVG@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	GO:0001775,GO:0002376,GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008283,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016020,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032943,GO:0034404,GO:0034641,GO:0034654,GO:0040007,GO:0042098,GO:0042100,GO:0042110,GO:0042113,GO:0042221,GO:0042455,GO:0042493,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045321,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0046649,GO:0046651,GO:0050896,GO:0055086,GO:0070661,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_1276,iECO103_1326.ECO103_3323,iNJ661.Rv1699,iPC815.YPO3377	CTP_synth_N,GATase
HKD1_k127_7309079_1	671143.DAMO_0270	3.652e-210	667.0	COG1132@1|root,COG1132@2|Bacteria,2NNVD@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02021,ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.110,3.A.1.112,3.A.1.113,3.A.1.117,3.A.1.21	-	iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	ABC_membrane,ABC_tran
HKD1_k127_7317135_0	269799.Gmet_1174	5.577e-88	301.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,43T01@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_7318035_1	673860.AciM339_0895	4.871e-21	92.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,3F32N@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	cyclic 2,3-diphosphoglycerate synthetase activity	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD1_k127_7318035_0	663278.Ethha_1704	5.078e-183	586.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,3WGXK@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
HKD1_k127_7318111_2	1089553.Tph_c26030	1.256e-15	83.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_7318111_0	1449076.JOOE01000002_gene835	1.358e-75	264.0	COG2159@1|root,COG2159@2|Bacteria,1Q704@1224|Proteobacteria,2VD3Z@28211|Alphaproteobacteria,2K7IV@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_7318111_1	1047013.AQSP01000038_gene1970	9.444e-33	131.0	COG2002@1|root,COG2002@2|Bacteria	2|Bacteria	K	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD1_k127_7318111_3	562970.Btus_3044	2.407e-10	64.0	COG2026@1|root,COG2026@2|Bacteria,1VBJJ@1239|Firmicutes,4HS7M@91061|Bacilli	91061|Bacilli	DJ	Addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7330135_3	1123256.KB907929_gene3371	1.954e-39	159.0	COG0330@1|root,COG0330@2|Bacteria,1N5JY@1224|Proteobacteria,1RQKM@1236|Gammaproteobacteria,1X8SY@135614|Xanthomonadales	135614|Xanthomonadales	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_7330135_0	317619.ANKN01000206_gene2647	6.994e-150	481.0	COG1335@1|root,COG1335@2|Bacteria,1G10P@1117|Cyanobacteria	1117|Cyanobacteria	Q	isochorismatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7330135_1	997346.HMPREF9374_0925	6.756e-74	266.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,4H9RW@91061|Bacilli,27B18@186824|Thermoactinomycetaceae	91061|Bacilli	G	Ribulose-phosphate 3 epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_7330135_4	1499967.BAYZ01000016_gene6560	4.394e-17	92.0	COG2815@1|root,COG2815@2|Bacteria,2NPV8@2323|unclassified Bacteria	2|Bacteria	S	PASTA	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA
HKD1_k127_7330135_2	671143.DAMO_1898	3.703e-68	241.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,2NP36@2323|unclassified Bacteria	2|Bacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0030312,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176,2.1.1.178	ko:K03500,ko:K11392,ko:K21970	-	-	-	-	ko00000,ko01000,ko03009,ko03029	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD1_k127_7337619_0	1040986.ATYO01000015_gene635	3.97e-37	153.0	COG0666@1|root,COG0666@2|Bacteria,1NC5F@1224|Proteobacteria,2UNCX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG0666 FOG Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_4
HKD1_k127_7337619_3	673862.BABL1_857	4.265e-07	61.0	COG0666@1|root,COG0666@2|Bacteria,1N952@1224|Proteobacteria	1224|Proteobacteria	KT	ankyrin repeat	-	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	Ank_2,Ank_4
HKD1_k127_7337619_1	1121439.dsat_2402	1.223e-27	121.0	COG0778@1|root,COG0778@2|Bacteria,1RDJ6@1224|Proteobacteria,42UA9@68525|delta/epsilon subdivisions,2WQX6@28221|Deltaproteobacteria,2MBX2@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_7337619_4	1040989.AWZU01000054_gene3481	4.106e-05	56.0	28JIP@1|root,2Z82C@2|Bacteria,1R5N9@1224|Proteobacteria,2U42A@28211|Alphaproteobacteria,3JTWI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
HKD1_k127_7337619_2	1341151.ASZU01000003_gene2371	3.673e-19	100.0	COG0477@1|root,COG2814@2|Bacteria,1TQHD@1239|Firmicutes,4HBCZ@91061|Bacilli,27D2T@186824|Thermoactinomycetaceae	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7355842_2	644282.Deba_0308	5.034e-40	164.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
HKD1_k127_7355842_3	575540.Isop_2969	4.244e-39	161.0	COG4923@1|root,COG4923@2|Bacteria	2|Bacteria	K	Protein of unknown function (DUF429)	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DUF429
HKD1_k127_7355842_0	443144.GM21_0125	6.121e-122	407.0	COG2982@1|root,COG2982@2|Bacteria,1PJZH@1224|Proteobacteria	1224|Proteobacteria	M	Domain of Unknown Function (DUF748)	-	-	-	-	-	-	-	-	-	-	-	-	DUF748
HKD1_k127_7355842_4	1121937.AUHJ01000020_gene1283	1.774e-14	74.0	COG5487@1|root,COG5487@2|Bacteria,1PCW4@1224|Proteobacteria,1T6EH@1236|Gammaproteobacteria,46CAM@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD1_k127_7355842_6	999541.bgla_1g13660	3.115e-05	53.0	COG2823@1|root,COG2823@2|Bacteria,1NIM8@1224|Proteobacteria,2VY65@28216|Betaproteobacteria,1KABM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	BON domain	-	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HKD1_k127_7355842_5	631454.N177_2723	3.984e-07	57.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2V97E@28211|Alphaproteobacteria,1JQEI@119043|Rhodobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
HKD1_k127_7355842_1	352165.HMPREF7215_2093	1.012e-57	215.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD1_k127_7355842_7	1040989.AWZU01000013_gene1576	0.000194	46.0	COG1802@1|root,COG1802@2|Bacteria,1R3VI@1224|Proteobacteria,2VF5S@28211|Alphaproteobacteria,3JVCC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FCD	MA20_14155	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_735846_7	1265756.AWZW01000008_gene709	8.577e-117	384.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,2U0KM@28211|Alphaproteobacteria,4BSS3@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Receptor family ligand binding region	MA20_16480	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_735846_10	466038.KI421440_gene250	2.751e-97	326.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,2TSH5@28211|Alphaproteobacteria,4BS7R@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	MA20_16475	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_735846_12	479434.Sthe_2886	8.812e-94	331.0	COG4177@1|root,COG4177@2|Bacteria,2G8KF@200795|Chloroflexi,27YZG@189775|Thermomicrobia	189775|Thermomicrobia	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_735846_21	1265756.AWZW01000008_gene712	4.289e-69	244.0	COG0411@1|root,COG0411@2|Bacteria,1MVAU@1224|Proteobacteria,2TVRN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	MA20_02440	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_735846_20	1499967.BAYZ01000159_gene528	4.616e-73	252.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_735846_11	671143.DAMO_1047	1.113e-94	316.0	COG1540@1|root,COG1540@2|Bacteria,2NQVM@2323|unclassified Bacteria	2|Bacteria	S	LamB/YcsF family	ycsF	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
HKD1_k127_735846_5	1120972.AUMH01000021_gene2299	3.208e-140	465.0	COG1984@1|root,COG2049@1|root,COG1984@2|Bacteria,COG2049@2|Bacteria,1TR6U@1239|Firmicutes,4HACC@91061|Bacilli,278QH@186823|Alicyclobacillaceae	91061|Bacilli	E	Allophanate hydrolase subunit 2	kipA	-	-	ko:K06350	-	-	-	-	ko00000	-	-	-	CT_A_B
HKD1_k127_735846_28	1231190.NA8A_23152	8.467e-40	161.0	2DB6N@1|root,2Z7HZ@2|Bacteria,1PQ9P@1224|Proteobacteria,2UCD3@28211|Alphaproteobacteria,43PQ1@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4392)	-	-	4.2.1.48	ko:K22210	ko00471,map00471	-	R01583	RC00553	ko00000,ko00001,ko01000	-	-	-	DUF4392
HKD1_k127_735846_4	671143.DAMO_1052	5.44e-157	519.0	COG1085@1|root,COG1085@2|Bacteria,2NQQM@2323|unclassified Bacteria	2|Bacteria	C	Domain of unknown function (DUF4921)	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0896	DUF4921,GalP_UDP_tr_C,GalP_UDP_transf
HKD1_k127_735846_8	1499967.BAYZ01000014_gene6352	3.089e-109	397.0	COG0642@1|root,COG2205@2|Bacteria	1499967.BAYZ01000014_gene6352|-	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_735846_29	565034.BHWA1_00688	5.599e-31	127.0	COG0784@1|root,COG0784@2|Bacteria,2J835@203691|Spirochaetes	203691|Spirochaetes	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_735846_25	671143.DAMO_1053	2.737e-57	201.0	COG0347@1|root,COG0347@2|Bacteria,2NR63@2323|unclassified Bacteria	2|Bacteria	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_735846_1	706587.Desti_3607	5.859e-244	760.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,42M7A@68525|delta/epsilon subdivisions,2WJ8P@28221|Deltaproteobacteria,2MR6S@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_735846_0	671143.DAMO_1057	1.77e-311	985.0	COG1391@1|root,COG1391@2|Bacteria	2|Bacteria	H	[glutamate-ammonia-ligase] adenylyltransferase activity	glnE	GO:0000166,GO:0000287,GO:0000820,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006521,GO:0006541,GO:0006542,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0008882,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0010565,GO:0016053,GO:0016740,GO:0016772,GO:0016779,GO:0017076,GO:0019222,GO:0019752,GO:0030554,GO:0031323,GO:0032553,GO:0032555,GO:0032559,GO:0033238,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046872,GO:0050789,GO:0050794,GO:0051171,GO:0062012,GO:0065007,GO:0070566,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD1_k127_735846_24	1123376.AUIU01000019_gene1235	7.226e-59	214.0	COG2220@1|root,COG2220@2|Bacteria	2|Bacteria	S	N-acetylphosphatidylethanolamine-hydrolysing phospholipas activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD1_k127_735846_15	1040989.AWZU01000003_gene6625	1.407e-83	295.0	COG1653@1|root,COG1653@2|Bacteria,1R5NT@1224|Proteobacteria,2TTRQ@28211|Alphaproteobacteria,3JSBR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_735846_14	113395.AXAI01000002_gene5147	5.354e-87	297.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,2TZRR@28211|Alphaproteobacteria,3JTDV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_735846_13	309801.trd_1136	2.598e-93	314.0	COG0395@1|root,COG0395@2|Bacteria,2GBU5@200795|Chloroflexi,27YRY@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_735846_35	632292.Calhy_2423	8.303e-19	93.0	COG1661@1|root,COG1661@2|Bacteria,1VJDC@1239|Firmicutes,25DY9@186801|Clostridia,42H9K@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
HKD1_k127_735846_16	234267.Acid_1104	3.811e-82	283.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_735846_38	395493.BegalDRAFT_3096	3.601e-15	87.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,462QP@72273|Thiotrichales	72273|Thiotrichales	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_735846_23	1395571.TMS3_0111250	1.068e-63	220.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Belongs to the MsrB Met sulfoxide reductase family	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR,TAT_signal
HKD1_k127_735846_33	1173022.Cri9333_2274	4.391e-24	109.0	COG3339@1|root,COG3339@2|Bacteria,1G7DF@1117|Cyanobacteria,1HFS6@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD1_k127_735846_32	693661.Arcve_0343	2.283e-24	105.0	COG0607@1|root,arCOG02021@2157|Archaea,2XY1R@28890|Euryarchaeota,246BX@183980|Archaeoglobi	183980|Archaeoglobi	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_735846_40	1038869.AXAN01000110_gene2201	1.263e-12	80.0	COG3012@1|root,COG3012@2|Bacteria,1NV40@1224|Proteobacteria,2VQPU@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Pfam SEC-C motif	-	-	-	-	-	-	-	-	-	-	-	-	SEC-C
HKD1_k127_735846_41	96561.Dole_0085	2.875e-09	59.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,42V85@68525|delta/epsilon subdivisions,2WR93@28221|Deltaproteobacteria,2MNZM@213118|Desulfobacterales	28221|Deltaproteobacteria	O	PFAM nitrogen-fixing NifU	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
HKD1_k127_735846_18	264732.Moth_1861	1.079e-77	268.0	COG1122@1|root,COG1122@2|Bacteria,1V16T@1239|Firmicutes,25B0D@186801|Clostridia,42EPN@68295|Thermoanaerobacterales	186801|Clostridia	P	pfam abc	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD1_k127_735846_30	309801.trd_A0603	8.426e-28	128.0	COG0619@1|root,COG0619@2|Bacteria,2G7CE@200795|Chloroflexi	200795|Chloroflexi	P	TIGRFAM cobalt ABC transporter, inner membrane subunit CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD1_k127_735846_36	319225.Plut_1451	9.234e-19	97.0	COG0310@1|root,COG0310@2|Bacteria	2|Bacteria	P	cobalt ion transport	-	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	PDGLE
HKD1_k127_735846_22	429009.Adeg_1959	5.457e-69	241.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia,42FFY@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM	nikMN	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
HKD1_k127_735846_26	273068.TTE0250	3.34e-50	182.0	COG0864@1|root,COG0864@2|Bacteria,1V5TB@1239|Firmicutes,24HRD@186801|Clostridia,42G9E@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD1_k127_735846_6	396588.Tgr7_0460	1.897e-130	425.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_735846_3	713586.KB900536_gene2578	2.755e-161	519.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1WWZV@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD1_k127_735846_2	713586.KB900536_gene2577	3.367e-206	668.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,1RNQN@1236|Gammaproteobacteria,1WX6D@135613|Chromatiales	135613|Chromatiales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD1_k127_735846_17	631362.Thi970DRAFT_01159	6.708e-79	276.0	COG1716@1|root,COG2200@1|root,COG1716@2|Bacteria,COG2200@2|Bacteria,1R86G@1224|Proteobacteria,1RQQ2@1236|Gammaproteobacteria,1X0QH@135613|Chromatiales	135613|Chromatiales	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,FHA
HKD1_k127_735846_9	717605.Theco_3925	3.807e-99	327.0	COG1225@1|root,COG1225@2|Bacteria,1V058@1239|Firmicutes,4HE2H@91061|Bacilli,26T9E@186822|Paenibacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_735846_31	880073.Calab_3689	1.917e-27	119.0	COG1145@1|root,COG1145@2|Bacteria,2NPVR@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	yfhL	-	-	ko:K03522,ko:K05337	-	-	-	-	ko00000,ko04147	-	-	-	Fer4,Fer4_7
HKD1_k127_735846_19	304371.MCP_2833	1.573e-73	261.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8ES@28890|Euryarchaeota,2NAX7@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
HKD1_k127_735846_34	671143.DAMO_1183	2.087e-21	97.0	COG1669@1|root,COG1669@2|Bacteria	2|Bacteria	S	nucleotidyltransferase activity	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86,NTP_transf_2
HKD1_k127_7367721_4	1340493.JNIF01000004_gene223	8.969e-72	243.0	COG1917@1|root,COG1917@2|Bacteria,3Y4HX@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7367721_6	68194.JNXR01000004_gene4340	4.523e-17	85.0	COG0586@1|root,COG0586@2|Bacteria,2GKKC@201174|Actinobacteria	201174|Actinobacteria	I	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_7367721_0	880072.Desac_0289	1.355e-163	538.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,42MTY@68525|delta/epsilon subdivisions,2WKII@28221|Deltaproteobacteria,2MQ9N@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	TIGRFAM Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iAF987.Gmet_1434	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_7367721_3	671143.DAMO_2787	2.038e-123	407.0	COG0301@1|root,COG0301@2|Bacteria,2NPBT@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	GO:0000049,GO:0002937,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0017144,GO:0018130,GO:0019438,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0042364,GO:0042723,GO:0042724,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:0090304,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	iECNA114_1301.ECNA114_0400,iECO26_1355.ECO26_0455,iECSF_1327.ECSF_0383,iSDY_1059.SDY_0307	THUMP,ThiI
HKD1_k127_7367721_2	1131553.JIBI01000032_gene2309	2.184e-127	431.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2VK3I@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Chloride channel	clcA_1	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD1_k127_7367721_5	56780.SYN_01247	1.922e-25	109.0	2DCXT@1|root,2ZFR8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7367721_1	404589.Anae109_3191	5.717e-153	501.0	COG1719@1|root,COG3829@1|root,COG1719@2|Bacteria,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M2E@68525|delta/epsilon subdivisions,2WKAB@28221|Deltaproteobacteria,2YWDZ@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat,V4R,XylR_N
HKD1_k127_7367721_7	243231.GSU1723	2.248e-12	69.0	COG0668@1|root,COG0668@2|Bacteria,1N66N@1224|Proteobacteria,42MXP@68525|delta/epsilon subdivisions,2WMI1@28221|Deltaproteobacteria,43S3A@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_7386575_3	1234364.AMSF01000085_gene2956	6.047e-07	52.0	arCOG08211@1|root,2ZBM3@2|Bacteria,1RIRV@1224|Proteobacteria,1SFXN@1236|Gammaproteobacteria,1X59H@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7386575_0	926560.KE387027_gene437	3.332e-107	366.0	COG1541@1|root,COG1541@2|Bacteria,1WM4P@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7386575_1	1217718.ALOU01000035_gene2548	3.241e-30	122.0	COG4320@1|root,COG4320@2|Bacteria,1N6EW@1224|Proteobacteria,2VN9A@28216|Betaproteobacteria,1K2DQ@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD1_k127_7413599_5	909663.KI867150_gene2687	6.365e-96	327.0	COG0659@1|root,COG0659@2|Bacteria,1MX1U@1224|Proteobacteria,42QCR@68525|delta/epsilon subdivisions,2WIP7@28221|Deltaproteobacteria,2MQDZ@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Molybdate transporter of MFS superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_MOT1
HKD1_k127_7413599_16	1121441.AUCX01000009_gene2579	2.132e-31	130.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2X5R7@28221|Deltaproteobacteria,2MGUN@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_7413599_14	1035308.AQYY01000002_gene108	2.713e-42	162.0	COG2059@1|root,COG2059@2|Bacteria,1TSKA@1239|Firmicutes,24EVY@186801|Clostridia,262SQ@186807|Peptococcaceae	186801|Clostridia	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_7413599_7	1532558.JL39_23415	1.783e-82	296.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,4BE6T@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K13889	ko02010,ko02024,map02010,map02024	M00239,M00348	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.11	-	-	SBP_bac_5
HKD1_k127_7413599_9	290398.Csal_3214	2.556e-75	265.0	COG1638@1|root,COG1638@2|Bacteria,1MWAM@1224|Proteobacteria	1224|Proteobacteria	G	TRAP-type C4-dicarboxylate transport system periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_7413599_21	1499967.BAYZ01000011_gene5204	3.811e-14	78.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689,ko:K21394	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_7413599_1	1121939.L861_06640	6.708e-145	471.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7413599_3	264732.Moth_2346	2.825e-115	382.0	COG0407@1|root,COG0407@2|Bacteria,1TR8Q@1239|Firmicutes,24B2U@186801|Clostridia,42IQ4@68295|Thermoanaerobacterales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	2.1.1.246,4.1.1.37	ko:K01599,ko:K14080	ko00680,ko00860,ko01100,ko01110,ko01120,ko01200,map00680,map00860,map01100,map01110,map01120,map01200	M00121,M00356	R03197,R04972,R09098,R10000	RC00035,RC00872,RC01144,RC02440	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_7413599_10	768672.Desfe_0691	8.127e-65	236.0	COG1363@1|root,arCOG01518@2157|Archaea,2XPWC@28889|Crenarchaeota	28889|Crenarchaeota	G	peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD1_k127_7413599_4	525904.Tter_0353	1.354e-109	363.0	COG1446@1|root,COG1446@2|Bacteria,2NPFC@2323|unclassified Bacteria	2|Bacteria	E	Asparaginase	asnA2	GO:0005575,GO:0005623,GO:0042597,GO:0044464	3.4.19.5,3.5.1.1,3.5.1.26	ko:K01424,ko:K01444,ko:K13051	ko00250,ko00460,ko00511,ko01100,ko01110,ko04142,map00250,map00460,map00511,map01100,map01110,map04142	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2
HKD1_k127_7413599_15	1123023.JIAI01000002_gene5010	4.971e-33	133.0	COG0662@1|root,COG0662@2|Bacteria,2IEY6@201174|Actinobacteria,4EBSD@85010|Pseudonocardiales	201174|Actinobacteria	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7413599_17	671143.DAMO_3081	2.514e-30	127.0	COG0792@1|root,COG0792@2|Bacteria,2NPW8@2323|unclassified Bacteria	2|Bacteria	L	Nuclease-related domain	yraN	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD1_k127_7413599_11	765914.ThisiDRAFT_2429	3.063e-55	201.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,1RQ4B@1236|Gammaproteobacteria,1WYG2@135613|Chromatiales	135613|Chromatiales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_7413599_13	1052684.PPM_1860	4.251e-46	168.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,4HIK3@91061|Bacilli,26XIV@186822|Paenibacillaceae	91061|Bacilli	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD1_k127_7413599_6	671143.DAMO_3084	4.663e-84	286.0	COG0336@1|root,COG0336@2|Bacteria,2NP5G@2323|unclassified Bacteria	2|Bacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0040007,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228,4.6.1.12	ko:K00554,ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R00597,R05637	RC00002,RC00003,RC00334,RC01440	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD1_k127_7413599_20	525904.Tter_1632	1.395e-21	101.0	COG0806@1|root,COG0806@2|Bacteria,2NPUX@2323|unclassified Bacteria	2|Bacteria	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0022607,GO:0022613,GO:0022618,GO:0030490,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0040007,GO:0042254,GO:0042255,GO:0042274,GO:0043170,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD1_k127_7413599_19	671143.DAMO_3086	4.721e-23	101.0	COG1837@1|root,COG1837@2|Bacteria,2NPUP@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the UPF0109 family	CP_0960	GO:0008150,GO:0040007	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD1_k127_7413599_18	525309.HMPREF0494_1821	2.793e-29	119.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,4HKNN@91061|Bacilli,3F6VV@33958|Lactobacillaceae	91061|Bacilli	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD1_k127_7413599_0	880072.Desac_0742	2.255e-171	548.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,42M94@68525|delta/epsilon subdivisions,2WINB@28221|Deltaproteobacteria,2MQ7R@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_7413599_23	682795.AciX8_2132	1.888e-06	50.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3Y3N9@57723|Acidobacteria,2JHWT@204432|Acidobacteriia	204432|Acidobacteriia	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
HKD1_k127_7413599_8	234267.Acid_1248	7.329e-79	273.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3Y3N9@57723|Acidobacteria	57723|Acidobacteria	P	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese,SNARE_assoc
HKD1_k127_7413599_2	269799.Gmet_3488	1.401e-125	413.0	2DBVK@1|root,2ZBBH@2|Bacteria,1PWZS@1224|Proteobacteria,432W2@68525|delta/epsilon subdivisions,2WXWI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_7413599_22	1163408.UU9_05629	3.064e-09	60.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,1XCUZ@135614|Xanthomonadales	135614|Xanthomonadales	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N
HKD1_k127_7413599_12	1038860.AXAP01000029_gene681	9.755e-48	174.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2U0D0@28211|Alphaproteobacteria,3JURI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose-6-phosphate dehydrogenase, NAD binding domain	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD1_k127_7416000_1	1267533.KB906742_gene787	1.378e-18	89.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y333@57723|Acidobacteria	2|Bacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD1_k127_7416000_0	1267535.KB906767_gene2603	8.144e-112	370.0	COG1082@1|root,COG1082@2|Bacteria	2|Bacteria	G	myo-inosose-2 dehydratase activity	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,BNR_4
HKD1_k127_7417060_0	1499967.BAYZ01000159_gene547	6.232e-139	458.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	dppA	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_7417060_4	688269.Theth_1105	5.767e-45	173.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_7417060_3	748280.NH8B_2921	3.537e-88	295.0	COG0778@1|root,COG0778@2|Bacteria,1R9VX@1224|Proteobacteria,2VQ1J@28216|Betaproteobacteria,2KQ41@206351|Neisseriales	206351|Neisseriales	C	NADH dehydrogenase NAD(P)H nitroreductase	-	-	-	ko:K09019	ko00240,ko01100,map00240,map01100	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HKD1_k127_7417060_1	1380394.JADL01000002_gene1603	5.843e-121	405.0	COG1024@1|root,COG1024@2|Bacteria,1NTWU@1224|Proteobacteria,2UPY0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_7417060_5	1297742.A176_00452	6.766e-05	51.0	COG1977@1|root,COG1977@2|Bacteria,1N15U@1224|Proteobacteria,42XSH@68525|delta/epsilon subdivisions,2WTDG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_7417060_2	471855.Shel_04450	2.775e-102	357.0	COG2414@1|root,COG2414@2|Bacteria,2IF1J@201174|Actinobacteria,4CV7Z@84998|Coriobacteriia	84998|Coriobacteriia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_7419872_2	631454.N177_0159	1.555e-248	784.0	COG0028@1|root,COG0028@2|Bacteria,1R743@1224|Proteobacteria,2U4KA@28211|Alphaproteobacteria,1JPSX@119043|Rhodobiaceae	28211|Alphaproteobacteria	EH	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain	-	-	3.7.1.22	ko:K03336	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08603	RC02331	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_7419872_11	1123504.JQKD01000005_gene4741	2.069e-59	222.0	COG2230@1|root,COG2230@2|Bacteria,1QX5S@1224|Proteobacteria,2WHKW@28216|Betaproteobacteria,4AJZM@80864|Comamonadaceae	28216|Betaproteobacteria	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_7419872_10	1232410.KI421428_gene1003	2.21e-62	232.0	COG2199@1|root,COG2199@2|Bacteria,1R80Z@1224|Proteobacteria,42RXX@68525|delta/epsilon subdivisions,2WNME@28221|Deltaproteobacteria,43TKF@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD1_k127_7419872_9	909663.KI867150_gene1801	2.197e-68	254.0	COG0030@1|root,COG0030@2|Bacteria,1N4P9@1224|Proteobacteria,42U3C@68525|delta/epsilon subdivisions,2WQY9@28221|Deltaproteobacteria,2MRGV@213462|Syntrophobacterales	28221|Deltaproteobacteria	J	Ribosomal RNA adenine dimethylase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_7419872_0	1487953.JMKF01000027_gene1460	2.948e-279	893.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1G217@1117|Cyanobacteria,1H72M@1150|Oscillatoriales	1117|Cyanobacteria	CE	Belongs to the aldehyde dehydrogenase family	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh
HKD1_k127_7419872_7	1382356.JQMP01000003_gene2006	9.08e-116	379.0	COG0395@1|root,COG0395@2|Bacteria,2GBU5@200795|Chloroflexi,27YRY@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_7419872_5	1382356.JQMP01000003_gene2005	3.252e-118	388.0	COG1175@1|root,COG1175@2|Bacteria,2GA2Q@200795|Chloroflexi,27Z2H@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02025	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_7419872_4	1382356.JQMP01000003_gene2004	1.151e-155	503.0	COG1653@1|root,COG1653@2|Bacteria,2GBCK@200795|Chloroflexi,27Z27@189775|Thermomicrobia	189775|Thermomicrobia	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_8
HKD1_k127_7419872_3	1121422.AUMW01000013_gene1430	1.408e-178	578.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,263WA@186807|Peptococcaceae	186801|Clostridia	H	Aminotransferase class-III	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7419872_8	1265505.ATUG01000002_gene2223	3.396e-106	362.0	2EZF4@1|root,33SK9@2|Bacteria,1NSZP@1224|Proteobacteria,42Z5G@68525|delta/epsilon subdivisions,2WTY8@28221|Deltaproteobacteria,2MMQ4@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7419872_1	926569.ANT_16580	9.987e-249	786.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi	200795|Chloroflexi	C	PFAM CoA-binding domain protein	-	-	6.2.1.13	ko:K01905,ko:K22224	ko00010,ko00620,ko00640,ko01100,ko01120,map00010,map00620,map00640,map01100,map01120	-	R00229,R00920	RC00004,RC00012,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD1_k127_7419872_6	469381.Dpep_1657	5.162e-117	389.0	COG1301@1|root,COG1301@2|Bacteria,3T9WV@508458|Synergistetes	508458|Synergistetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD1_k127_7456271_0	1120971.AUCA01000004_gene1313	1.13e-175	571.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli,27812@186823|Alicyclobacillaceae	91061|Bacilli	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD1_k127_7459601_1	1499967.BAYZ01000014_gene6413	1.377e-88	300.0	COG0411@1|root,COG0411@2|Bacteria,2NNYG@2323|unclassified Bacteria	2|Bacteria	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7459601_0	1499967.BAYZ01000014_gene6412	2.873e-92	310.0	COG0410@1|root,COG0410@2|Bacteria,2NNXF@2323|unclassified Bacteria	2|Bacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_7469050_10	1048339.KB913029_gene3356	1.105e-06	51.0	COG3547@1|root,COG3547@2|Bacteria,2IBF5@201174|Actinobacteria,4ERQ9@85013|Frankiales	201174|Actinobacteria	L	Transposase	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_7469050_6	1382359.JIAL01000001_gene361	2.621e-41	160.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_7469050_1	573.JG24_27235	8.824e-158	514.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,1RM8W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	mltF2	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K18691	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	SBP_bac_3,SLT
HKD1_k127_7469050_2	522306.CAP2UW1_0198	2.294e-150	484.0	COG0560@1|root,COG0560@2|Bacteria,1MW38@1224|Proteobacteria,2VN83@28216|Betaproteobacteria	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_7469050_0	1454004.AW11_03212	0.0	1028.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria,1KR2K@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	P	C-terminal region of aryl-sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,Sulfatase_C
HKD1_k127_7469050_5	909663.KI867150_gene893	4.495e-64	227.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_7469050_9	1380391.JIAS01000002_gene3204	5.472e-09	61.0	2EGQI@1|root,33AGP@2|Bacteria,1NHU7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
HKD1_k127_7469050_11	478741.JAFS01000001_gene2119	2.134e-05	54.0	COG2197@1|root,COG2197@2|Bacteria,46SRM@74201|Verrucomicrobia,37G3I@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7469050_4	706587.Desti_2130	8.888e-73	252.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,43AV8@68525|delta/epsilon subdivisions,2X69B@28221|Deltaproteobacteria,2MSKC@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7469050_3	1211777.BN77_p11114	7.36e-89	321.0	COG2202@1|root,COG2984@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2984@2|Bacteria,COG4585@2|Bacteria,1R3TZ@1224|Proteobacteria,2U1UX@28211|Alphaproteobacteria,4B83E@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA_3
HKD1_k127_7469050_7	1244869.H261_19019	2.023e-19	93.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2JT7W@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD1_k127_7475186_4	472759.Nhal_0278	2.635e-12	73.0	2EBQI@1|root,335QJ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HKD1_k127_7475186_3	1089546.AQUI01000002_gene250	1.341e-25	112.0	2E3TC@1|root,32YQV@2|Bacteria,2GXYE@201174|Actinobacteria	201174|Actinobacteria	S	copG family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7475186_2	1397528.Q671_15125	1.488e-26	115.0	COG2929@1|root,COG2929@2|Bacteria,1MZKJ@1224|Proteobacteria,1S984@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD1_k127_7475186_1	909663.KI867150_gene1677	1.125e-77	276.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,42NZ8@68525|delta/epsilon subdivisions,2WK0Y@28221|Deltaproteobacteria,2MQIM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Beta-lactamase enzyme family	-	-	3.4.16.4	ko:K01286,ko:K07258,ko:K07262	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_7475186_0	1380394.JADL01000017_gene482	1.507e-119	395.0	COG1921@1|root,COG1921@2|Bacteria,1MWCB@1224|Proteobacteria,2TXI4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	L-seryl-tRNA selenium transferase	-	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	SelA
HKD1_k127_7483886_2	1198114.AciX9_2743	2.372e-45	175.0	COG2223@1|root,COG2223@2|Bacteria,3Y3PZ@57723|Acidobacteria,2JICB@204432|Acidobacteriia	204432|Acidobacteriia	P	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HKD1_k127_7483886_0	316067.Geob_0512	2.668e-79	269.0	COG1584@1|root,COG1584@2|Bacteria,1N3HP@1224|Proteobacteria,42QSA@68525|delta/epsilon subdivisions,2WN08@28221|Deltaproteobacteria,43SQD@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	GPR1/FUN34/yaaH family	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD1_k127_7483886_1	1283300.ATXB01000001_gene2242	5.873e-51	187.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,1S6JM@1236|Gammaproteobacteria,1XE76@135618|Methylococcales	135618|Methylococcales	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD1_k127_7495103_2	1054213.HMPREF9946_03303	3.022e-20	92.0	COG3181@1|root,COG3181@2|Bacteria,1MU58@1224|Proteobacteria,2TQWK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_7495103_0	891968.Anamo_1620	9.232e-129	421.0	COG2423@1|root,COG2423@2|Bacteria,3TAM6@508458|Synergistetes	508458|Synergistetes	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1	ko:K19244	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HKD1_k127_7495103_1	309801.trd_0049	3.661e-106	360.0	COG0617@1|root,COG0617@2|Bacteria,2G6B7@200795|Chloroflexi,27Y1Y@189775|Thermomicrobia	189775|Thermomicrobia	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_7495956_3	204669.Acid345_3939	8.747e-19	85.0	COG0531@1|root,COG0531@2|Bacteria,3Y356@57723|Acidobacteria,2JP5J@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7495956_0	595537.Varpa_4906	6.999e-98	325.0	COG0861@1|root,COG0861@2|Bacteria,1MWC9@1224|Proteobacteria,2VJSY@28216|Betaproteobacteria,4AC5T@80864|Comamonadaceae	28216|Betaproteobacteria	P	Membrane protein TerC	terC	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,TerC
HKD1_k127_7495956_2	1415778.JQMM01000001_gene761	4.225e-68	247.0	COG0668@1|root,COG0668@2|Bacteria,1N596@1224|Proteobacteria,1RQZP@1236|Gammaproteobacteria,1JC09@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	COG0668 Small-conductance mechanosensitive channel	mscS	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022607,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0031226,GO:0032535,GO:0034220,GO:0042592,GO:0042802,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0048878,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055082,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0071840,GO:0071944,GO:0090066	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
HKD1_k127_7495956_1	706587.Desti_5055	1.709e-95	331.0	COG1032@1|root,COG1032@2|Bacteria,1MWR0@1224|Proteobacteria	1224|Proteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Dak2,DegV,Radical_SAM
HKD1_k127_7506680_0	234267.Acid_3157	8.116e-83	293.0	COG3488@1|root,COG3488@2|Bacteria,3Y3DB@57723|Acidobacteria	57723|Acidobacteria	C	Di-haem oxidoreductase, putative peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
HKD1_k127_7506680_1	379066.GAU_2937	6.741e-44	168.0	COG1999@1|root,COG2847@1|root,COG1999@2|Bacteria,COG2847@2|Bacteria	2|Bacteria	P	Copper chaperone PCu(A)C	hyaE	GO:0003674,GO:0005048,GO:0005488,GO:0033218,GO:0042277	-	ko:K03619,ko:K07152,ko:K09796	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	HyaE,PCuAC,SCO1-SenC
HKD1_k127_7506680_2	1151119.KB895512_gene199	1.737e-40	162.0	COG3794@1|root,COG3794@2|Bacteria	2|Bacteria	C	PFAM blue (type 1) copper domain protein	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	CCP_MauG,Copper-bind,Cu-oxidase_3,Cupredoxin_1
HKD1_k127_7509391_1	485913.Krac_6355	2.125e-27	115.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_7509391_3	485913.Krac_7936	1.824e-12	73.0	COG0675@1|root,COG0675@2|Bacteria	2|Bacteria	L	Transposase, IS605 OrfB family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD1_k127_7509391_0	383372.Rcas_0194	2.074e-127	421.0	COG3385@1|root,COG3385@2|Bacteria,2G80K@200795|Chloroflexi	200795|Chloroflexi	L	sptr a7nhu5	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_7509391_2	886293.Sinac_2736	2.255e-17	88.0	COG5433@1|root,COG5433@2|Bacteria,2J2DN@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_7518809_1	517418.Ctha_1022	2.358e-05	49.0	COG4974@1|root,COG4974@2|Bacteria,1FESB@1090|Chlorobi	1090|Chlorobi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_7518809_0	96561.Dole_1741	2.781e-79	279.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1REEI@1224|Proteobacteria,42RTM@68525|delta/epsilon subdivisions,2WNS4@28221|Deltaproteobacteria,2MMKQ@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HKD1_k127_7529900_0	566466.NOR53_845	3.183e-40	158.0	COG3637@1|root,COG3637@2|Bacteria,1RI4B@1224|Proteobacteria,1S8IK@1236|Gammaproteobacteria,1J6HR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD1_k127_7529900_2	335543.Sfum_0590	8.647e-28	121.0	2BQW2@1|root,32JT0@2|Bacteria,1QNFB@1224|Proteobacteria,432XH@68525|delta/epsilon subdivisions,2WYDA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7529900_3	196367.JNFG01000037_gene7583	4.482e-19	98.0	COG4566@1|root,COG4566@2|Bacteria,1MZ8E@1224|Proteobacteria,2VYAI@28216|Betaproteobacteria,1K8D8@119060|Burkholderiaceae	28216|Betaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_7529900_1	1038859.AXAU01000004_gene4560	1.438e-30	123.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3JQPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7532065_0	926560.KE387023_gene1701	2.992e-154	506.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_7532065_1	215803.DB30_7899	4.534e-07	57.0	2DN1Z@1|root,32V20@2|Bacteria,1Q8W3@1224|Proteobacteria,43E1M@68525|delta/epsilon subdivisions,2WZFP@28221|Deltaproteobacteria,2Z21B@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7555122_15	671143.DAMO_0055	2.721e-128	424.0	COG0342@1|root,COG0342@2|Bacteria,2NNNU@2323|unclassified Bacteria	2|Bacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_7555122_25	479434.Sthe_0191	1.29e-72	255.0	COG3662@1|root,COG3662@2|Bacteria,2G8VS@200795|Chloroflexi,27YAB@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterized protein conserved in bacteria (DUF2236)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD1_k127_7555122_26	204773.HEAR1836	1.383e-68	238.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VRSQ@28216|Betaproteobacteria,47588@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_7555122_2	323097.Nham_0995	0.0	1028.0	COG3387@1|root,COG3387@2|Bacteria,1MYVI@1224|Proteobacteria,2TVIW@28211|Alphaproteobacteria,3JXU9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucodextranase, domain N	cga	-	3.2.1.3	ko:K01178	ko00500,ko01100,map00500,map01100	-	R01790,R01791,R06199	-	ko00000,ko00001,ko01000	-	GH15	-	Glucodextran_N,Glyco_hydro_15
HKD1_k127_7555122_12	326427.Cagg_3495	3.176e-164	524.0	COG1063@1|root,COG1063@2|Bacteria,2G8I2@200795|Chloroflexi,376PK@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HKD1_k127_7555122_40	523841.HFX_1391	7.965e-06	58.0	arCOG09309@1|root,arCOG09309@2157|Archaea,2XW0B@28890|Euryarchaeota,23U6E@183963|Halobacteria	183963|Halobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_7555122_34	383372.Rcas_2592	2.277e-49	186.0	COG0477@1|root,COG2814@2|Bacteria,2GBRU@200795|Chloroflexi,376BN@32061|Chloroflexia	32061|Chloroflexia	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7555122_37	326427.Cagg_3496	1.035e-28	123.0	COG0477@1|root,COG2814@2|Bacteria,2GBRU@200795|Chloroflexi,376BN@32061|Chloroflexia	32061|Chloroflexia	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7555122_16	383372.Rcas_1531	4.674e-122	402.0	COG0508@1|root,COG0508@2|Bacteria,2G7SG@200795|Chloroflexi,3767X@32061|Chloroflexia	32061|Chloroflexia	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_7555122_1	1128421.JAGA01000003_gene3230	0.0	1043.0	COG0567@1|root,COG0567@2|Bacteria,2NQJV@2323|unclassified Bacteria	2|Bacteria	C	Dehydrogenase E1 component	sucA	GO:0000287,GO:0003674,GO:0003824,GO:0004591,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006103,GO:0008150,GO:0008152,GO:0008683,GO:0009055,GO:0009060,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016624,GO:0016740,GO:0016744,GO:0016829,GO:0016830,GO:0016831,GO:0016903,GO:0016999,GO:0017144,GO:0019752,GO:0019842,GO:0022900,GO:0030312,GO:0030976,GO:0032991,GO:0036094,GO:0040007,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045239,GO:0045240,GO:0045252,GO:0045254,GO:0045333,GO:0046872,GO:0048037,GO:0050439,GO:0050662,GO:0051186,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0097159,GO:1901363,GO:1901681,GO:1902494,GO:1990204,GO:1990234	1.2.4.2,4.1.1.71	ko:K00164,ko:K01616	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv1248c,iSSON_1240.SSON_0677,iYL1228.KPN_00732	2-oxoacid_dh,2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD1_k127_7555122_29	1267535.KB906767_gene1284	1.846e-66	235.0	COG2128@1|root,COG2128@2|Bacteria,3Y4TK@57723|Acidobacteria,2JJJ6@204432|Acidobacteriia	204432|Acidobacteriia	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_7555122_7	269799.Gmet_2619	4.939e-212	671.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,42M0J@68525|delta/epsilon subdivisions,2WK1D@28221|Deltaproteobacteria,43TGS@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD1_k127_7555122_20	649638.Trad_1384	1.005e-97	340.0	COG2041@1|root,COG2041@2|Bacteria,1WI25@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Mo-co oxidoreductase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD1_k127_7555122_41	83406.HDN1F_11850	1.434e-05	48.0	COG2010@1|root,COG2132@1|root,COG2010@2|Bacteria,COG2132@2|Bacteria,1R8PP@1224|Proteobacteria,1RZ8B@1236|Gammaproteobacteria,1JBBJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_C,Cytochrome_CBB3,F5_F8_type_C
HKD1_k127_7555122_30	234267.Acid_6330	2.485e-65	231.0	COG1102@1|root,COG1102@2|Bacteria,3Y50F@57723|Acidobacteria	57723|Acidobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_7555122_6	234267.Acid_6331	2.238e-215	681.0	COG0477@1|root,COG2814@2|Bacteria,3Y46V@57723|Acidobacteria	57723|Acidobacteria	P	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD1_k127_7555122_22	941449.dsx2_0705	2.05e-86	301.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,42S77@68525|delta/epsilon subdivisions,2X5PF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Biotin-lipoyl like	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_7555122_24	857087.Metme_2507	4.674e-78	269.0	COG1018@1|root,COG1018@2|Bacteria,1RAS4@1224|Proteobacteria,1SXIT@1236|Gammaproteobacteria,1XG2E@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_1
HKD1_k127_7555122_14	1267535.KB906767_gene67	5.356e-142	469.0	COG1007@1|root,COG1007@2|Bacteria,3Y3PV@57723|Acidobacteria,2JIT3@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD1_k127_7555122_9	1123368.AUIS01000006_gene666	5.097e-200	637.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,2NCKR@225057|Acidithiobacillales	1236|Gammaproteobacteria	C	Proton-conducting membrane transporter	nuoM	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0045333,GO:0048037,GO:0048038,GO:0048039,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1902600,GO:1990204	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iSDY_1059.SDY_2473	Proton_antipo_M
HKD1_k127_7555122_5	105559.Nwat_1911	1.875e-253	796.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,1RNKN@1236|Gammaproteobacteria,1WWQ6@135613|Chromatiales	135613|Chromatiales	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_7555122_36	706587.Desti_4753	3.608e-36	149.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,42VAT@68525|delta/epsilon subdivisions,2WRE5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK-2	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_7555122_33	105559.Nwat_1909	8.253e-54	194.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S65T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the complex I subunit 6 family	nuoJ	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008137,GO:0008150,GO:0008152,GO:0016020,GO:0016021,GO:0016491,GO:0016651,GO:0016655,GO:0030964,GO:0031224,GO:0031226,GO:0032991,GO:0044425,GO:0044459,GO:0044464,GO:0045271,GO:0045272,GO:0050136,GO:0055114,GO:0070469,GO:0070470,GO:0071944,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	e_coli_core.b2280,iAF1260.b2280,iAPECO1_1312.APECO1_4285,iB21_1397.B21_02165,iBWG_1329.BWG_2054,iE2348C_1286.E2348C_2420,iEC042_1314.EC042_2521,iEC55989_1330.EC55989_2524,iECABU_c1320.ECABU_c26120,iECBD_1354.ECBD_1381,iECB_1328.ECB_02205,iECDH10B_1368.ECDH10B_2442,iECDH1ME8569_1439.ECDH1ME8569_2217,iECD_1391.ECD_02205,iECED1_1282.ECED1_2744,iECH74115_1262.ECH74115_3419,iECIAI1_1343.ECIAI1_2354,iECIAI39_1322.ECIAI39_2427,iECNA114_1301.ECNA114_2370,iECO103_1326.ECO103_2744,iECO111_1330.ECO111_3028,iECO26_1355.ECO26_3268,iECOK1_1307.ECOK1_2513,iECP_1309.ECP_2319,iECS88_1305.ECS88_2427,iECSE_1348.ECSE_2537,iECSF_1327.ECSF_2157,iECSP_1301.ECSP_3154,iECUMN_1333.ECUMN_2619,iECW_1372.ECW_m2468,iECs_1301.ECs3164,iEKO11_1354.EKO11_1487,iETEC_1333.ETEC_2415,iEcDH1_1363.EcDH1_1377,iEcE24377_1341.EcE24377A_2573,iEcHS_1320.EcHS_A2429,iEcSMS35_1347.EcSMS35_2434,iEcolC_1368.EcolC_1372,iJO1366.b2280,iJR904.b2280,iLF82_1304.LF82_1547,iNRG857_1313.NRG857_11545,iSBO_1134.SBO_2313,iSDY_1059.SDY_2476,iSFV_1184.SFV_2347,iSF_1195.SF2356,iSFxv_1172.SFxv_2600,iSSON_1240.SSON_2337,iS_1188.S2491,iSbBS512_1146.SbBS512_E2656,iUMN146_1321.UM146_05415,iUMNK88_1353.UMNK88_2830,iUTI89_1310.UTI89_C2560,iWFL_1372.ECW_m2468,iY75_1357.Y75_RS11955,iZ_1308.Z3539,ic_1306.c2821	Oxidored_q3
HKD1_k127_7555122_21	323848.Nmul_A1020	1.439e-92	310.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2WBX2@28216|Betaproteobacteria,373YS@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD1_k127_7555122_13	1267535.KB906767_gene61	2.056e-155	497.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria,2JHQZ@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	-	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HKD1_k127_7555122_0	1266925.JHVX01000004_gene1249	0.0	1177.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2VJYV@28216|Betaproteobacteria,373XN@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HKD1_k127_7555122_8	323848.Nmul_A1017	4.489e-207	651.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2VJJ1@28216|Betaproteobacteria,3745P@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_7555122_31	472759.Nhal_2138	2.697e-64	224.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	1236|Gammaproteobacteria	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_7555122_3	1123368.AUIS01000006_gene657	1.008e-304	942.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,2NBZB@225057|Acidithiobacillales	225057|Acidithiobacillales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K13378	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa
HKD1_k127_7555122_19	472759.Nhal_2141	5.362e-114	369.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_7555122_35	323848.Nmul_A1013	2.477e-46	171.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2W894@28216|Betaproteobacteria,3748A@32003|Nitrosomonadales	28216|Betaproteobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase, chain 3	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_7555122_38	1128421.JAGA01000003_gene2880	5.315e-20	96.0	2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria	2|Bacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HKD1_k127_7555122_28	1340493.JNIF01000004_gene143	9.074e-67	234.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_7555122_4	1123242.JH636434_gene3641	2.659e-277	863.0	COG0843@1|root,COG0843@2|Bacteria,2IXCQ@203682|Planctomycetes	203682|Planctomycetes	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_7555122_18	234267.Acid_0497	6.16e-117	385.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria	57723|Acidobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C,Cytochrome_CBB3
HKD1_k127_7555122_23	886293.Sinac_3660	1.721e-79	276.0	COG1999@1|root,COG1999@2|Bacteria,2IYYD@203682|Planctomycetes	203682|Planctomycetes	S	protein SCO1 SenC PrrC involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_7555122_39	1340493.JNIF01000004_gene147	3.598e-18	89.0	2EJZ3@1|root,33DPP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7555122_17	1128421.JAGA01000003_gene2874	4.662e-119	403.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7555122_27	234267.Acid_0493	6.332e-68	239.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_7555122_32	1128421.JAGA01000003_gene2872	2.938e-62	236.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD1_k127_7555122_10	1128421.JAGA01000003_gene2871	6.692e-194	615.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HKD1_k127_7555122_11	472759.Nhal_2603	6.648e-187	594.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria,1WWTE@135613|Chromatiales	135613|Chromatiales	C	PFAM 4Fe-4S	-	-	-	ko:K00184,ko:K21308	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R11487	RC00168	ko00000,ko00001	5.A.3	-	-	Fer4_11,Fer4_4,Fer4_7
HKD1_k127_7555756_0	926569.ANT_24980	6.939e-205	676.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,2G5QR@200795|Chloroflexi	200795|Chloroflexi	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD1_k127_7555756_1	926569.ANT_24970	4.256e-127	418.0	COG0016@1|root,COG0016@2|Bacteria,2G5T1@200795|Chloroflexi	200795|Chloroflexi	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_7555756_2	671143.DAMO_1862	5.876e-47	171.0	COG0292@1|root,COG0292@2|Bacteria,2NPQQ@2323|unclassified Bacteria	2|Bacteria	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	GO:0000027,GO:0000900,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0006355,GO:0006412,GO:0006417,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016020,GO:0016043,GO:0017148,GO:0019219,GO:0019222,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0030371,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045182,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0051252,GO:0060255,GO:0065003,GO:0065007,GO:0070180,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:0080090,GO:0090079,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2000113,GO:2001141	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD1_k127_7555756_3	1131462.DCF50_p1990	4.189e-13	71.0	COG0291@1|root,COG0291@2|Bacteria,1VF5W@1239|Firmicutes,24QJD@186801|Clostridia,262US@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD1_k127_7557608_3	1217718.ALOU01000038_gene3330	1.978e-183	587.0	COG4623@1|root,COG4623@2|Bacteria,1MWDS@1224|Proteobacteria,2VKSN@28216|Betaproteobacteria,1K51A@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_3,SLT
HKD1_k127_7557608_17	882.DVU_2785	4.484e-30	129.0	COG2186@1|root,COG2186@2|Bacteria,1MUP9@1224|Proteobacteria,42UKW@68525|delta/epsilon subdivisions,2WQIH@28221|Deltaproteobacteria,2M7SF@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Regulatory protein GntR HTH	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD1_k127_7557608_4	926692.AZYG01000047_gene2658	6.337e-149	488.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WAAB@53433|Halanaerobiales	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_7557608_5	671143.DAMO_3101	1.06e-148	482.0	COG3705@1|root,COG3705@2|Bacteria,2NQXE@2323|unclassified Bacteria	2|Bacteria	E	Histidyl-tRNA synthetase	hisZ	-	2.4.2.17,6.1.1.21	ko:K00765,ko:K01892,ko:K02502	ko00340,ko00970,ko01100,ko01110,ko01230,map00340,map00970,map01100,map01110,map01230	M00026,M00359,M00360	R01071,R03655	RC00055,RC00523,RC02819,RC03200	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_His
HKD1_k127_7557608_2	671143.DAMO_3100	1.367e-208	662.0	COG0111@1|root,COG0111@2|Bacteria,2NNZW@2323|unclassified Bacteria	2|Bacteria	EH	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD1_k127_7557608_6	671143.DAMO_3099	6.72e-142	461.0	COG0075@1|root,COG0075@2|Bacteria,2NP52@2323|unclassified Bacteria	2|Bacteria	E	Aminotransferase class-V	-	GO:0001505,GO:0003674,GO:0003824,GO:0004760,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006807,GO:0008150,GO:0008152,GO:0008453,GO:0008483,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0019265,GO:0019752,GO:0042133,GO:0042136,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_7557608_14	335543.Sfum_2001	5.748e-52	196.0	COG0697@1|root,COG0697@2|Bacteria,1MUQ7@1224|Proteobacteria,42R74@68525|delta/epsilon subdivisions,2WMRT@28221|Deltaproteobacteria,2MRGD@213462|Syntrophobacterales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_7557608_0	671143.DAMO_3136	0.0	1239.0	COG0060@1|root,COG0060@2|Bacteria,2NNT5@2323|unclassified Bacteria	2|Bacteria	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	GO:0003674,GO:0003824,GO:0004812,GO:0004822,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006428,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iG2583_1286.G2583_0027,iPC815.YPO0475	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD1_k127_7557608_15	671143.DAMO_3137	9.319e-48	177.0	COG0597@1|root,COG0597@2|Bacteria,2NPU1@2323|unclassified Bacteria	2|Bacteria	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD1_k127_7557608_9	671143.DAMO_3138	5.316e-105	349.0	COG0564@1|root,COG0564@2|Bacteria,2NNY5@2323|unclassified Bacteria	2|Bacteria	J	Responsible for synthesis of pseudouridine from uracil	rluD	GO:0000027,GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022607,GO:0022613,GO:0022618,GO:0031118,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:1901360	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	iE2348C_1286.E2348C_2868,iECED1_1282.ECED1_3035,iECSF_1327.ECSF_2432	PseudoU_synth_2,S4
HKD1_k127_7557608_19	671143.DAMO_2332	1.482e-22	101.0	COG1278@1|root,COG1278@2|Bacteria	2|Bacteria	K	Cold shock	cspA	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_7557608_21	99598.Cal7507_2165	6.905e-16	92.0	COG0823@1|root,COG0823@2|Bacteria,1G5RG@1117|Cyanobacteria,1HN96@1161|Nostocales	1117|Cyanobacteria	U	Periplasmic component of the Tol biopolymer transport system	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_7557608_1	671143.DAMO_2333	0.0	1028.0	COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria	2|Bacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_7557608_11	671143.DAMO_2334	1.321e-74	255.0	COG1403@1|root,COG1403@2|Bacteria,2NPJD@2323|unclassified Bacteria	2|Bacteria	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH,HNH_4,HNH_5
HKD1_k127_7557608_10	671143.DAMO_2335	2.319e-82	289.0	COG0248@1|root,COG0248@2|Bacteria,2NPR1@2323|unclassified Bacteria	2|Bacteria	FP	Ppx/GppA phosphatase family	ppx	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006793,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0040007,GO:0044237,GO:0044464,GO:0071944	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD1_k127_7557608_12	671143.DAMO_2336	4.125e-58	225.0	COG1293@1|root,COG1293@2|Bacteria,2NP83@2323|unclassified Bacteria	2|Bacteria	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_7557608_16	234267.Acid_7717	3.774e-34	139.0	COG1051@1|root,COG1051@2|Bacteria,3Y5BM@57723|Acidobacteria	57723|Acidobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_7557608_22	289376.THEYE_A0442	1.194e-10	70.0	COG2104@1|root,COG2104@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_7557608_7	671143.DAMO_2565	1.136e-125	406.0	COG2022@1|root,COG2022@2|Bacteria,2NQHA@2323|unclassified Bacteria	2|Bacteria	H	Thiazole biosynthesis protein ThiG	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HKD1_k127_7557608_13	671143.DAMO_2564	2.271e-52	198.0	COG0352@1|root,COG0352@2|Bacteria,2NPCU@2323|unclassified Bacteria	2|Bacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_7557608_18	671143.DAMO_2563	4.243e-29	128.0	COG3688@1|root,COG3688@2|Bacteria,2NQ5V@2323|unclassified Bacteria	2|Bacteria	S	YacP-like NYN domain	yacP	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_IV,GTP_EFTU,NYN_YacP
HKD1_k127_7557608_8	1382304.JNIL01000001_gene957	6.114e-124	408.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes,4HAM3@91061|Bacilli	91061|Bacilli	E	Threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_7557608_24	1144275.COCOR_00772	3.439e-08	67.0	COG0402@1|root,COG2374@1|root,COG0402@2|Bacteria,COG2374@2|Bacteria,1NFUA@1224|Proteobacteria,433MB@68525|delta/epsilon subdivisions,2WXJF@28221|Deltaproteobacteria,2YUGP@29|Myxococcales	28221|Deltaproteobacteria	F	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,DUF4215,LTD,TSP_3
HKD1_k127_7557608_20	1198114.AciX9_0601	1.997e-17	98.0	COG5492@1|root,COG5492@2|Bacteria,3Y3VF@57723|Acidobacteria,2JHRK@204432|Acidobacteriia	204432|Acidobacteriia	N	Bacterial Ig-like domain 2	-	-	-	-	-	-	-	-	-	-	-	-	Big_2
HKD1_k127_7559226_20	867845.KI911784_gene3238	1.207e-104	353.0	COG1454@1|root,COG1454@2|Bacteria,2G6IU@200795|Chloroflexi,376B8@32061|Chloroflexia	32061|Chloroflexia	C	PFAM iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD1_k127_7559226_47	436229.JOEH01000018_gene1131	2.167e-53	198.0	COG1414@1|root,COG1414@2|Bacteria,2HFKK@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD1_k127_7559226_21	675635.Psed_3718	4.645e-104	344.0	COG1028@1|root,COG1028@2|Bacteria,2IGX2@201174|Actinobacteria,4E2WI@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_7559226_65	1232437.KL661965_gene3208	1.445e-21	101.0	COG1545@1|root,COG1545@2|Bacteria,1RFF1@1224|Proteobacteria,42RS5@68525|delta/epsilon subdivisions,2WN9R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	DUF35 OB-fold domain, acyl-CoA-associated	bbsA	-	-	ko:K07549	ko00623,ko01100,ko01120,ko01220,map00623,map01100,map01120,map01220	M00418	R05587	RC00004,RC01428,RC02904	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD1_k127_7559226_11	1448389.BAVQ01000082_gene593	3.091e-125	413.0	COG0183@1|root,COG0183@2|Bacteria,2GIY0@201174|Actinobacteria	201174|Actinobacteria	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_7559226_7	1224163.B841_09470	1.402e-139	458.0	COG1804@1|root,COG1804@2|Bacteria,2GIU7@201174|Actinobacteria,22KUE@1653|Corynebacteriaceae	201174|Actinobacteria	C	acyl-CoA transferases carnitine dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_7559226_18	1206725.BAFU01000020_gene3467	2.105e-108	363.0	COG1063@1|root,COG1063@2|Bacteria,2GKBE@201174|Actinobacteria,4FXD2@85025|Nocardiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	adh	-	1.1.1.1,1.1.1.14	ko:K00001,ko:K00008	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	M00014	R00623,R00754,R00875,R01896,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00085,RC00087,RC00088,RC00099,RC00102,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7559226_55	1100720.ALKN01000045_gene319	1.043e-42	172.0	COG3181@1|root,COG3181@2|Bacteria,1N7C4@1224|Proteobacteria,2VHNI@28216|Betaproteobacteria,4A9W4@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM conserved	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_7559226_72	931627.MycrhDRAFT_4001	3.851e-05	51.0	293R6@1|root,2ZR6U@2|Bacteria,2HRYX@201174|Actinobacteria,23843@1762|Mycobacteriaceae	201174|Actinobacteria	S	Tripartite tricarboxylate transporter TctB family	-	-	-	ko:K07794	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctB
HKD1_k127_7559226_5	631454.N177_3011	5.072e-175	561.0	COG3333@1|root,COG3333@2|Bacteria,1MUKR@1224|Proteobacteria,2TR4Q@28211|Alphaproteobacteria,1JNPA@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Tripartite tricarboxylate transporter TctA family	-	-	-	-	-	-	-	-	-	-	-	-	TctA
HKD1_k127_7559226_37	675635.Psed_3725	1.91e-72	263.0	COG0683@1|root,COG0683@2|Bacteria,2IEFV@201174|Actinobacteria,4E5SY@85010|Pseudonocardiales	201174|Actinobacteria	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_7559226_39	675635.Psed_3734	3.536e-64	230.0	COG0559@1|root,COG0559@2|Bacteria,2GKAR@201174|Actinobacteria,4E4VX@85010|Pseudonocardiales	201174|Actinobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7559226_35	1121033.AUCF01000024_gene227	2.016e-75	269.0	COG4177@1|root,COG4177@2|Bacteria,1MU52@1224|Proteobacteria,2TSUI@28211|Alphaproteobacteria,2JSFM@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7559226_42	1121033.AUCF01000030_gene166	4.651e-60	216.0	COG0411@1|root,COG0411@2|Bacteria,1MUFT@1224|Proteobacteria,2U22X@28211|Alphaproteobacteria,2JS5W@204441|Rhodospirillales	204441|Rhodospirillales	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7559226_36	867903.ThesuDRAFT_01899	1.071e-73	256.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,3WCT4@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid amide ABC transporter ATP-binding protein 2, HAAT family	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_7559226_34	1231190.NA8A_02305	8.594e-76	271.0	COG2079@1|root,COG2079@2|Bacteria,1NECN@1224|Proteobacteria,2UQ0A@28211|Alphaproteobacteria,43RMY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Mmge prpd family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_7559226_50	639030.JHVA01000001_gene600	7.938e-46	175.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria,2JI6U@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_7559226_73	345341.KUTG_03582	0.0001409	46.0	2DPFE@1|root,331UR@2|Bacteria,2ISSB@201174|Actinobacteria,4EBYK@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF664)	-	-	-	-	-	-	-	-	-	-	-	-	DUF664
HKD1_k127_7559226_44	706587.Desti_3677	5.694e-55	200.0	COG0045@1|root,COG0045@2|Bacteria,1REBV@1224|Proteobacteria,42S1F@68525|delta/epsilon subdivisions,2WNW1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5
HKD1_k127_7559226_28	224325.AF_1938	4.424e-88	308.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,2XT9G@28890|Euryarchaeota,246RE@183980|Archaeoglobi	183980|Archaeoglobi	C	acetyl coenzyme A synthetase	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD1_k127_7559226_41	1089553.Tph_c09590	2.234e-60	219.0	2DBZQ@1|root,2ZC2Y@2|Bacteria,1V2KN@1239|Firmicutes,24G8V@186801|Clostridia,42I8U@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7559226_46	639283.Snov_3525	2.147e-53	199.0	COG2267@1|root,COG2267@2|Bacteria,1MX0N@1224|Proteobacteria	1224|Proteobacteria	I	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD1_k127_7559226_54	675635.Psed_3722	2.273e-43	161.0	2DMMM@1|root,32SHA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7559226_60	1396418.BATQ01000017_gene4173	2.273e-27	115.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,Cupin_3
HKD1_k127_7559226_31	910964.GEAM_4139	4.718e-80	277.0	COG0491@1|root,COG0491@2|Bacteria,1N22F@1224|Proteobacteria,1SYHJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_7559226_12	671143.DAMO_2098	2.761e-124	406.0	COG0604@1|root,COG0604@2|Bacteria,2NQR7@2323|unclassified Bacteria	2|Bacteria	C	Zinc-binding dehydrogenase	qor	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7559226_49	631454.N177_3042	2.209e-50	185.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950,ko:K09163	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_7559226_15	374847.Kcr_0658	4.133e-118	389.0	COG2358@1|root,arCOG01801@2157|Archaea	2157|Archaea	S	TRAP transporter solute receptor, TAXI family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD1_k127_7559226_2	374847.Kcr_0659	3.788e-203	650.0	COG4666@1|root,arCOG01906@2157|Archaea	2157|Archaea	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7559226_27	204669.Acid345_3920	2.249e-89	307.0	COG1063@1|root,COG1063@2|Bacteria,3Y3KU@57723|Acidobacteria,2JIQ4@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7559226_22	891968.Anamo_1264	7.443e-103	344.0	COG1071@1|root,COG1071@2|Bacteria,3TA5N@508458|Synergistetes	508458|Synergistetes	C	E1 component	pdhA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD1_k127_7559226_14	697303.Thewi_1629	6.037e-121	396.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,42F56@68295|Thermoanaerobacterales	186801|Clostridia	C	Transketolase, central region	acoB	-	1.2.4.4	ko:K11381,ko:K21417	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_7559226_17	572547.Amico_1588	9.888e-110	364.0	COG1638@1|root,COG1638@2|Bacteria,3TA1W@508458|Synergistetes	508458|Synergistetes	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_7559226_64	1304874.JAFY01000002_gene327	1.749e-23	106.0	COG3090@1|root,COG3090@2|Bacteria,3TB63@508458|Synergistetes	508458|Synergistetes	G	PFAM Tripartite ATP-independent periplasmic	-	-	-	ko:K11689	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_7559226_8	1121403.AUCV01000003_gene1740	1.578e-135	443.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,42Q21@68525|delta/epsilon subdivisions,2WJSG@28221|Deltaproteobacteria,2MIS7@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7559226_25	1207063.P24_03930	1.466e-91	308.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TRWN@28211|Alphaproteobacteria,2JRJC@204441|Rhodospirillales	204441|Rhodospirillales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_7559226_16	891968.Anamo_1264	1.606e-111	372.0	COG1071@1|root,COG1071@2|Bacteria,3TA5N@508458|Synergistetes	508458|Synergistetes	C	E1 component	pdhA	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD1_k127_7559226_13	1449126.JQKL01000003_gene1819	7.688e-123	410.0	COG0022@1|root,COG0022@2|Bacteria,1TP3J@1239|Firmicutes,249UD@186801|Clostridia,26AI0@186813|unclassified Clostridiales	186801|Clostridia	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_7559226_0	671143.DAMO_0088	4.691e-248	781.0	COG3276@1|root,COG3276@2|Bacteria,2NNQU@2323|unclassified Bacteria	2|Bacteria	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD1_k127_7559226_66	671143.DAMO_0089	2.428e-18	85.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_7559226_19	880072.Desac_1113	9.941e-107	355.0	COG3191@1|root,COG3191@2|Bacteria,1MWDP@1224|Proteobacteria,42QPY@68525|delta/epsilon subdivisions,2WMQC@28221|Deltaproteobacteria,2MQD4@213462|Syntrophobacterales	28221|Deltaproteobacteria	EQ	PFAM Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HKD1_k127_7559226_68	1144275.COCOR_05561	5.337e-12	72.0	COG3215@1|root,COG3215@2|Bacteria,1Q2S4@1224|Proteobacteria,43266@68525|delta/epsilon subdivisions,2WXR8@28221|Deltaproteobacteria,2YVFJ@29|Myxococcales	28221|Deltaproteobacteria	NU	PilZ domain	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD1_k127_7559226_1	671143.DAMO_3080	3.359e-235	736.0	COG0606@1|root,COG0606@2|Bacteria,2NNW7@2323|unclassified Bacteria	2|Bacteria	O	Magnesium chelatase, subunit ChlI C-terminal	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_7559226_48	477974.Daud_0256	4.137e-51	186.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,261PA@186807|Peptococcaceae	186801|Clostridia	J	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_7559226_29	1499967.BAYZ01000016_gene6566	2.584e-86	294.0	COG0363@1|root,COG0363@2|Bacteria,2NR1W@2323|unclassified Bacteria	2|Bacteria	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	nagB	-	3.1.1.31,3.5.99.6	ko:K01057,ko:K02564	ko00030,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00520,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R00765,R02035	RC00163,RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD1_k127_7559226_6	1304877.KI519399_gene2903	1.11e-149	487.0	COG0154@1|root,COG0154@2|Bacteria,1MWRI@1224|Proteobacteria,2TTJU@28211|Alphaproteobacteria,3JVBW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_7559226_32	395961.Cyan7425_4809	2.118e-78	273.0	COG2199@1|root,COG3706@2|Bacteria,1G5BB@1117|Cyanobacteria,3KGBC@43988|Cyanothece	1117|Cyanobacteria	T	PFAM GGDEF domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD1_k127_7559226_59	880072.Desac_0513	9.496e-29	128.0	COG1102@1|root,COG1102@2|Bacteria,1R1X4@1224|Proteobacteria,43DC5@68525|delta/epsilon subdivisions,2X8I5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_7559226_71	1151127.KB906331_gene3495	2.413e-06	56.0	2AGYE@1|root,31775@2|Bacteria,1PYGK@1224|Proteobacteria,1RVTQ@1236|Gammaproteobacteria,1YUD6@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2846)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2846
HKD1_k127_7559226_63	536019.Mesop_5238	2.477e-26	110.0	COG5470@1|root,COG5470@2|Bacteria,1PJHZ@1224|Proteobacteria,2UDNK@28211|Alphaproteobacteria,43QKC@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD1_k127_7559226_23	640511.BC1002_5675	1.675e-99	332.0	COG0395@1|root,COG0395@2|Bacteria,1MVVT@1224|Proteobacteria,2VT22@28216|Betaproteobacteria,1KGTI@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026,ko:K17323	ko02010,map02010	M00207,M00607	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.35	-	-	BPD_transp_1
HKD1_k127_7559226_26	1038860.AXAP01000001_gene6416	1.043e-90	307.0	COG1175@1|root,COG1175@2|Bacteria,1R6Q5@1224|Proteobacteria,2U41X@28211|Alphaproteobacteria,3JV06@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_7559226_30	543728.Vapar_5703	9.728e-81	289.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2VW91@28216|Betaproteobacteria,4AFE1@80864|Comamonadaceae	28216|Betaproteobacteria	G	PFAM extracellular solute-binding protein family 1	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_7559226_56	1169161.KB897736_gene5310	3.248e-39	159.0	COG1621@1|root,COG1621@2|Bacteria,2GKT1@201174|Actinobacteria	201174|Actinobacteria	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7559226_69	1144310.PMI07_001373	1.033e-11	75.0	COG1881@1|root,COG1881@2|Bacteria,1R1AK@1224|Proteobacteria,2TZAD@28211|Alphaproteobacteria,4BHCB@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_7559226_40	1499967.BAYZ01000147_gene719	1.161e-61	225.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	MA20_20705	-	3.4.21.107	ko:K04691,ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_7559226_67	331869.BAL199_03734	8.222e-16	84.0	COG3909@1|root,COG3909@2|Bacteria,1PZYV@1224|Proteobacteria,2UN4Q@28211|Alphaproteobacteria,4BR3H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HKD1_k127_7559226_43	1380394.JADL01000011_gene3995	8.227e-57	209.0	COG2010@1|root,COG2010@2|Bacteria,1MV6D@1224|Proteobacteria,2TT9U@28211|Alphaproteobacteria,2JSE3@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_7559226_24	671143.DAMO_1639	3.496e-93	314.0	COG1355@1|root,COG1355@2|Bacteria,2NQ00@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0032886,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0065007	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD1_k127_7559226_51	671143.DAMO_2377	2.858e-44	164.0	COG1146@1|root,COG1146@2|Bacteria,2NPWS@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S binding domain	fdxA	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7
HKD1_k127_7559226_62	880073.Calab_2990	1.591e-26	116.0	COG0671@1|root,COG0671@2|Bacteria,2NPZ6@2323|unclassified Bacteria	2|Bacteria	I	Phosphoesterase, PA-phosphatase related	-	-	3.1.3.27,3.1.3.4,3.1.3.81,3.6.1.27	ko:K01096,ko:K19302	ko00550,ko00564,ko01100,map00550,map00564,map01100	-	R02029,R05627	RC00002,RC00017	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_7559226_38	671143.DAMO_1635	1.013e-66	253.0	COG0392@1|root,COG0392@2|Bacteria,2NPJC@2323|unclassified Bacteria	2|Bacteria	S	Lysylphosphatidylglycerol synthase TM region	mprF	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD1_k127_7559226_10	671143.DAMO_1634	2.415e-131	426.0	COG0463@1|root,COG0463@2|Bacteria,2NP2G@2323|unclassified Bacteria	2|Bacteria	M	Glycosyltransferase like family 2	arnC	GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_7559226_33	289376.THEYE_A0589	3.916e-76	276.0	COG0671@1|root,COG1807@1|root,COG0671@2|Bacteria,COG1807@2|Bacteria,3J155@40117|Nitrospirae	40117|Nitrospirae	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,PMT_2
HKD1_k127_7559226_45	867903.ThesuDRAFT_01440	2.07e-54	196.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,3WCI7@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_7559226_4	671143.DAMO_1630	1.185e-182	580.0	COG0151@1|root,COG0151@2|Bacteria,2NP0B@2323|unclassified Bacteria	2|Bacteria	F	Belongs to the GARS family	purD	-	6.3.2.6,6.3.4.13,6.3.5.3	ko:K01945,ko:K01952,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04463,R04591	RC00010,RC00064,RC00090,RC00162,RC00166,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS05245,iYO844.BSU06530	GARS_A,GARS_C,GARS_N
HKD1_k127_7559226_3	671143.DAMO_1629	6.65e-185	592.0	COG0138@1|root,COG0138@2|Bacteria,2NNQ2@2323|unclassified Bacteria	2|Bacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
HKD1_k127_7559226_52	1125863.JAFN01000001_gene393	1.316e-43	169.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,42SBG@68525|delta/epsilon subdivisions,2WP66@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HKD1_k127_7559226_53	671143.DAMO_1022	2.247e-43	164.0	COG1959@1|root,COG1959@2|Bacteria,2NPZX@2323|unclassified Bacteria	2|Bacteria	K	Transcriptional regulator	cymR	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HKD1_k127_7559226_9	671143.DAMO_1024	1.698e-131	430.0	COG0476@1|root,COG1977@1|root,COG0476@2|Bacteria,COG1977@2|Bacteria,2NPX3@2323|unclassified Bacteria	2|Bacteria	H	ThiF family	moeB	-	2.7.7.73,2.7.7.80,2.8.1.11	ko:K03148,ko:K03636,ko:K21029,ko:K21147	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
HKD1_k127_7559226_57	671143.DAMO_1029	6.081e-31	129.0	COG1310@1|root,COG1310@2|Bacteria	2|Bacteria	S	proteolysis	-	-	2.7.7.80,2.8.1.11,3.13.1.6	ko:K21140,ko:K21147	ko04122,map04122	-	R07459,R07461,R11524	RC00043,RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB,Rhodanese,ThiF
HKD1_k127_7559226_70	1125863.JAFN01000001_gene1928	2.051e-07	59.0	COG0745@1|root,COG0745@2|Bacteria	1125863.JAFN01000001_gene1928|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7559226_58	314345.SPV1_14254	2.161e-29	120.0	COG1977@1|root,COG1977@2|Bacteria,1N4Z0@1224|Proteobacteria	1224|Proteobacteria	H	Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_7559226_74	1121904.ARBP01000055_gene488	0.0003695	46.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689,ko:K21394	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_7563708_7	443598.AUFA01000127_gene7209	5.929e-17	81.0	COG2984@1|root,COG2984@2|Bacteria,1RDUT@1224|Proteobacteria,2U8XC@28211|Alphaproteobacteria,3JYZA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_4	318996.AXAZ01000095_gene4941	2.711e-60	223.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_9	941449.dsx2_0928	4.857e-08	57.0	COG1225@1|root,COG1225@2|Bacteria,1N9JS@1224|Proteobacteria,42R82@68525|delta/epsilon subdivisions,2WMVA@28221|Deltaproteobacteria,2MBM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HKD1_k127_7563708_8	671065.MetMK1DRAFT_00018060	1.293e-13	75.0	COG1225@1|root,arCOG00310@2157|Archaea,2XQPI@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_7563708_6	1037409.BJ6T_61420	2.01e-41	166.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_2	189753.AXAS01000041_gene2534	1.304e-85	297.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_1	113395.AXAI01000035_gene44	2.541e-98	334.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JYHD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_0	318996.AXAZ01000095_gene4941	8.073e-134	434.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_3	189753.AXAS01000041_gene2534	3.066e-84	291.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7563708_5	189753.AXAS01000041_gene2534	6.785e-47	181.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_7577663_0	886293.Sinac_0928	1.473e-259	816.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7577663_1	622637.KE124774_gene3470	1.096e-11	68.0	COG1484@1|root,COG1484@2|Bacteria,1MWQX@1224|Proteobacteria,2TRGY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA replication protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_7584265_0	879212.DespoDRAFT_01479	5.509e-118	396.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,42VIF@68525|delta/epsilon subdivisions,2WRY1@28221|Deltaproteobacteria,2MQ11@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7584265_1	13689.BV96_04745	4.901e-26	114.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,2K2UN@204457|Sphingomonadales	204457|Sphingomonadales	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_7609947_0	243231.GSU2171	1.204e-113	377.0	COG2801@1|root,COG2801@2|Bacteria,1R7WH@1224|Proteobacteria,43AIP@68525|delta/epsilon subdivisions,2X5YX@28221|Deltaproteobacteria	1224|Proteobacteria	L	HTH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve
HKD1_k127_7609947_1	243231.GSU2170	3.503e-19	91.0	2DTBN@1|root,33JKH@2|Bacteria,1NBVZ@1224|Proteobacteria,42XUQ@68525|delta/epsilon subdivisions,2WTFT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7609947_2	1121106.JQKB01000170_gene5398	4.204e-06	52.0	2DTBN@1|root,33JKH@2|Bacteria,1NBVZ@1224|Proteobacteria,2VFY2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD1_k127_7611569_0	1299327.I546_5948	2.248e-88	313.0	28NDD@1|root,2ZBG6@2|Bacteria,2H1UZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7612168_1	880072.Desac_0292	4.889e-97	320.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,42M44@68525|delta/epsilon subdivisions,2WJFW@28221|Deltaproteobacteria,2MQRJ@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_7612168_0	706587.Desti_4204	5.429e-188	594.0	COG0467@1|root,COG1476@1|root,COG1917@1|root,COG0467@2|Bacteria,COG1476@2|Bacteria,COG1917@2|Bacteria,1PE60@1224|Proteobacteria,42NFD@68525|delta/epsilon subdivisions,2WK1C@28221|Deltaproteobacteria,2MQST@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD1_k127_7615153_4	502025.Hoch_3949	3.887e-28	118.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,42R50@68525|delta/epsilon subdivisions,2X3AE@28221|Deltaproteobacteria,2YV4E@29|Myxococcales	28221|Deltaproteobacteria	S	nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_7615153_3	1158338.JNLJ01000001_gene1077	2.62e-79	270.0	COG1611@1|root,COG1611@2|Bacteria,2G4W3@200783|Aquificae	200783|Aquificae	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_7615153_2	671143.DAMO_0479	1.225e-122	403.0	COG3437@1|root,COG3437@2|Bacteria,2NPBP@2323|unclassified Bacteria	2|Bacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
HKD1_k127_7615153_0	671143.DAMO_1216	2.081e-255	796.0	COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria	2|Bacteria	I	carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_7615153_1	671143.DAMO_1217	9.319e-142	465.0	COG0439@1|root,COG0439@2|Bacteria,2NNKD@2323|unclassified Bacteria	2|Bacteria	I	carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2,6.4.1.3,6.4.1.4	ko:K01961,ko:K01965,ko:K01968,ko:K11263	ko00061,ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00280,map00620,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00036,M00082,M00373,M00376,M00741	R00742,R01859,R04138,R04385	RC00040,RC00097,RC00253,RC00367,RC00609,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD1_k127_7615153_5	1144275.COCOR_01071	0.0009538	45.0	COG4770@1|root,COG4770@2|Bacteria,1RJYU@1224|Proteobacteria,42WT6@68525|delta/epsilon subdivisions,2WSN5@28221|Deltaproteobacteria,2YVN7@29|Myxococcales	28221|Deltaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HKD1_k127_7620674_10	335543.Sfum_3137	6.868e-15	78.0	COG1146@1|root,COG1146@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	fdxA	-	1.2.7.3	ko:K00176,ko:K05524	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	DUF3470,Fer4,Fer4_4
HKD1_k127_7620674_1	335543.Sfum_3138	7.261e-140	456.0	COG0674@1|root,COG0674@2|Bacteria,1NBSJ@1224|Proteobacteria,42MS1@68525|delta/epsilon subdivisions,2WJ97@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_7620674_2	335543.Sfum_3139	1.348e-116	387.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,42MD3@68525|delta/epsilon subdivisions,2WJQ0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Thiamine pyrophosphate	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_7620674_9	644281.MFS40622_0306	7.523e-44	166.0	COG1014@1|root,arCOG01602@2157|Archaea,2XUK0@28890|Euryarchaeota,23QJ8@183939|Methanococci	183939|Methanococci	C	PFAM Pyruvate	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_7620674_3	909663.KI867149_gene3379	4.943e-115	382.0	COG0045@1|root,COG0045@2|Bacteria,1R6QD@1224|Proteobacteria,42P2U@68525|delta/epsilon subdivisions,2WJAY@28221|Deltaproteobacteria,2MRBA@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	ATP-grasp domain	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_7620674_5	909663.KI867149_gene3380	1.54e-101	338.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,42M2W@68525|delta/epsilon subdivisions,2WJBV@28221|Deltaproteobacteria,2MQR9@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA-ligase	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,CoA_binding,Ligase_CoA,Succ_CoA_lig
HKD1_k127_7620674_6	1125863.JAFN01000001_gene198	3.027e-95	323.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42M6M@68525|delta/epsilon subdivisions,2WIQM@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EJ	PFAM Pyridoxal-5'-phosphate-dependent protein beta subunit	cysM	-	2.5.1.47,6.1.1.16	ko:K01738,ko:K01883,ko:K12339	ko00270,ko00920,ko00970,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map00970,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00359,M00360	R00897,R03132,R03601,R03650,R04859	RC00020,RC00055,RC00523,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,PALP,tRNA-synt_1e
HKD1_k127_7620674_4	1120971.AUCA01000021_gene1048	6.054e-110	362.0	COG2897@1|root,COG2897@2|Bacteria,1TRYA@1239|Firmicutes,4HAQA@91061|Bacilli,278AM@186823|Alicyclobacillaceae	91061|Bacilli	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_7620674_0	1122185.N792_08220	0.0	1022.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1SJQ1@1236|Gammaproteobacteria,1X5IA@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_7620674_8	1267535.KB906767_gene332	4.774e-49	178.0	COG3189@1|root,COG3189@2|Bacteria,3Y88F@57723|Acidobacteria,2JN90@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_7620674_7	479434.Sthe_0632	6.765e-56	202.0	COG0122@1|root,COG0122@2|Bacteria,2G8TI@200795|Chloroflexi,27YWG@189775|Thermomicrobia	189775|Thermomicrobia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_7667857_0	671143.DAMO_2966	1.253e-115	378.0	COG2876@1|root,COG2876@2|Bacteria,2NNPG@2323|unclassified Bacteria	2|Bacteria	E	PFAM DAHP synthetase I KDSA	aroG-2	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_7667857_1	368407.Memar_0454	2.999e-30	130.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y47Z@28890|Euryarchaeota,2NAXR@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_7667857_2	264731.PRU_2066	7.791e-10	61.0	COG0330@1|root,COG0330@2|Bacteria,4PCK8@976|Bacteroidetes,2FPVM@200643|Bacteroidia	976|Bacteroidetes	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_7678489_14	269797.Mbar_A2000	3.174e-17	87.0	COG3613@1|root,arCOG02434@2157|Archaea,2XZZI@28890|Euryarchaeota,2NBK5@224756|Methanomicrobia	224756|Methanomicrobia	F	Nucleoside 2-deoxyribosyltransferase like	-	-	2.4.2.6	ko:K08728	ko00240,map00240	-	R02806	RC00063	ko00000,ko00001,ko01000	-	-	-	Nuc_deoxyrib_tr
HKD1_k127_7678489_8	266117.Rxyl_0226	5.112e-67	237.0	COG0619@1|root,COG0619@2|Bacteria,2GUVM@201174|Actinobacteria	201174|Actinobacteria	P	Cobalt transport protein	-	-	-	ko:K16785	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
HKD1_k127_7678489_0	266117.Rxyl_0225	9.87e-154	511.0	COG1122@1|root,COG1122@2|Bacteria,2GJ0M@201174|Actinobacteria,4CPZK@84995|Rubrobacteria	84995|Rubrobacteria	P	PFAM ABC transporter related	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD1_k127_7678489_7	264732.Moth_0709	5.699e-82	280.0	COG0697@1|root,COG0697@2|Bacteria,1V4Y0@1239|Firmicutes,24HNS@186801|Clostridia,42G99@68295|Thermoanaerobacterales	186801|Clostridia	EG	QueT transporter	-	-	-	ko:K16928	-	M00582	-	-	ko00000,ko00002,ko02000	3.A.1.33	-	-	QueT
HKD1_k127_7678489_12	1128421.JAGA01000002_gene503	1.44e-30	126.0	COG0537@1|root,COG0537@2|Bacteria,2NPE0@2323|unclassified Bacteria	2|Bacteria	FG	HIT domain	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_7678489_19	1211112.ALJC01000087_gene1013	4.955e-05	49.0	COG1225@1|root,COG1225@2|Bacteria,1MWFZ@1224|Proteobacteria,1RZ28@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG1225 Peroxiredoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_7678489_16	700598.Niako_5497	1.394e-10	66.0	COG1225@1|root,COG1225@2|Bacteria,4NNHI@976|Bacteroidetes,1ISKK@117747|Sphingobacteriia	976|Bacteroidetes	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_7678489_18	1158292.JPOE01000002_gene3909	6.327e-09	59.0	COG0526@1|root,COG0526@2|Bacteria,1RIID@1224|Proteobacteria,2VUWV@28216|Betaproteobacteria,1KMES@119065|unclassified Burkholderiales	1224|Proteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_7678489_17	1430440.MGMSRv2_0253	7.311e-10	63.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2UG9E@28211|Alphaproteobacteria,2JY1I@204441|Rhodospirillales	204441|Rhodospirillales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_7678489_15	1120948.KB903224_gene366	5.629e-12	73.0	2AVNR@1|root,31MFR@2|Bacteria,2HBMC@201174|Actinobacteria	1120948.KB903224_gene366|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7678489_4	1380394.JADL01000020_gene1824	1.735e-103	349.0	COG0477@1|root,COG2814@2|Bacteria,1QUTR@1224|Proteobacteria,2TW7A@28211|Alphaproteobacteria,2JZ6R@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7678489_3	1173026.Glo7428_0087	9.106e-128	417.0	COG0265@1|root,COG0265@2|Bacteria,1G3M4@1117|Cyanobacteria	1117|Cyanobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_7678489_6	1347392.CCEZ01000008_gene2245	1.182e-89	302.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,248YJ@186801|Clostridia,36FEA@31979|Clostridiaceae	186801|Clostridia	C	nitroreductase	sagB	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_7678489_10	644966.Tmar_1716	9.745e-50	185.0	COG2318@1|root,COG2318@2|Bacteria,1V415@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF1572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
HKD1_k127_7678489_1	1499967.BAYZ01000118_gene3300	3.042e-136	445.0	COG1454@1|root,COG1454@2|Bacteria,2NQ5W@2323|unclassified Bacteria	2|Bacteria	C	Iron-containing alcohol dehydrogenase	CT0951	-	1.1.1.1,4.3.3.7	ko:K00001,ko:K01714,ko:K13954	ko00010,ko00071,ko00261,ko00300,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,ko01230,map00010,map00071,map00261,map00300,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220,map01230	M00016,M00525,M00526,M00527	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10147	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	Fe-ADH
HKD1_k127_7678489_13	550540.Fbal_1349	2.14e-30	125.0	2E74N@1|root,331P2@2|Bacteria,1RC0J@1224|Proteobacteria,1S2MI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7678489_11	1232410.KI421418_gene2423	2.891e-49	180.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,42TN6@68525|delta/epsilon subdivisions,2WQ6K@28221|Deltaproteobacteria,43V00@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_7678489_2	1009370.ALO_16172	1.668e-131	437.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,4H2EG@909932|Negativicutes	909932|Negativicutes	G	ABC transporter	-	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_7678489_5	1009370.ALO_16177	3.229e-93	317.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,4H2PF@909932|Negativicutes	909932|Negativicutes	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD1_k127_7678489_9	1123389.ATXJ01000029_gene119	1.498e-60	232.0	COG1879@1|root,COG1879@2|Bacteria,1WK3A@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD1_k127_7678663_15	1037409.BJ6T_41050	4.388e-34	135.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,2VF1H@28211|Alphaproteobacteria,3K6D7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7678663_7	1458275.AZ34_09485	5.438e-69	248.0	COG0411@1|root,COG0411@2|Bacteria,1MXHT@1224|Proteobacteria,2VMYA@28216|Betaproteobacteria,4AC90@80864|Comamonadaceae	1224|Proteobacteria	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7678663_8	1125863.JAFN01000001_gene1732	5.536e-67	238.0	COG0410@1|root,COG0410@2|Bacteria,1MVYI@1224|Proteobacteria,43AR1@68525|delta/epsilon subdivisions,2X64Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_7678663_16	136037.KDR09976	9.637e-05	49.0	KOG1721@1|root,KOG1721@2759|Eukaryota,3AI6X@33154|Opisthokonta,3BXX7@33208|Metazoa,3DE40@33213|Bilateria,4229N@6656|Arthropoda,3SQGG@50557|Insecta	33208|Metazoa	S	C2H2-type zinc finger	-	-	2.7.11.12	ko:K07376	ko04022,ko04270,ko04540,ko04611,ko04713,ko04714,ko04730,ko04740,ko04923,ko04970,map04022,map04270,map04540,map04611,map04713,map04714,map04730,map04740,map04923,map04970	M00694	-	-	ko00000,ko00001,ko00002,ko01000,ko01001	-	-	-	zf-C2H2,zf-C2H2_6
HKD1_k127_7678663_3	1449126.JQKL01000004_gene515	5.952e-100	341.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia	186801|Clostridia	C	Belongs to the LDH2 MDH2 oxidoreductase family	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_7678663_4	1499967.BAYZ01000028_gene1316	9.148e-86	300.0	COG1058@1|root,COG1058@2|Bacteria,2NP0G@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_7678663_9	518766.Rmar_1167	1.662e-65	232.0	COG1028@1|root,COG1028@2|Bacteria,4NEAI@976|Bacteroidetes,1FIW9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_7678663_11	330084.JNYZ01000011_gene7372	5.311e-57	211.0	COG0673@1|root,COG0673@2|Bacteria,2GM7J@201174|Actinobacteria,4E9C7@85010|Pseudonocardiales	201174|Actinobacteria	S	Oxidoreductase family, C-terminal alpha beta domain	-	-	1.1.1.18,1.1.1.369	ko:K00010	ko00521,ko00562,ko01100,ko01120,ko01130,map00521,map00562,map01100,map01120,map01130	-	R01183,R09951	RC00182	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_7678663_2	1298860.AUEM01000001_gene1686	3.171e-102	343.0	COG1052@1|root,COG1052@2|Bacteria,2IAIC@201174|Actinobacteria,4FN14@85023|Microbacteriaceae	201174|Actinobacteria	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_7678663_6	1232410.KI421412_gene194	8.061e-76	267.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,42R10@68525|delta/epsilon subdivisions,2WN3Z@28221|Deltaproteobacteria,43TG1@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	NADH pyrophosphatase-like rudimentary NUDIX domain	nudC	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD1_k127_7678663_5	1219049.SP5_080_00030	1.707e-85	294.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2K0HZ@204457|Sphingomonadales	28211|Alphaproteobacteria	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_7678663_13	1394178.AWOO02000017_gene6741	2.278e-47	185.0	COG1228@1|root,COG1228@2|Bacteria,2GMUS@201174|Actinobacteria,4EIKM@85012|Streptosporangiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_7678663_12	1313421.JHBV01000024_gene5019	2.24e-47	183.0	COG3012@1|root,COG3228@1|root,COG3012@2|Bacteria,COG3228@2|Bacteria,4NGM9@976|Bacteroidetes,1IRGU@117747|Sphingobacteriia	976|Bacteroidetes	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
HKD1_k127_7678663_14	243231.GSU0802	8.102e-47	177.0	COG1028@1|root,COG1028@2|Bacteria,1RBGC@1224|Proteobacteria,42TP6@68525|delta/epsilon subdivisions,2WQAU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_7678663_1	318586.Pden_1045	3.661e-131	426.0	COG3938@1|root,COG3938@2|Bacteria,1N02K@1224|Proteobacteria,2VGM8@28211|Alphaproteobacteria,2PWD0@265|Paracoccus	28211|Alphaproteobacteria	E	Belongs to the proline racemase family	-	-	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
HKD1_k127_7678663_10	518766.Rmar_1090	3.834e-65	235.0	COG1349@1|root,COG2865@1|root,COG1349@2|Bacteria,COG2865@2|Bacteria,4NGFJ@976|Bacteroidetes	976|Bacteroidetes	K	Divergent AAA domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4,HTH_11,HTH_24
HKD1_k127_7678663_0	1121405.dsmv_0171	4.185e-163	529.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria,2MI96@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
HKD1_k127_7700831_2	1232437.KL662012_gene1403	5.605e-20	93.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,43AYS@68525|delta/epsilon subdivisions,2X6D2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_7700831_1	321332.CYB_2084	6.025e-62	223.0	COG0559@1|root,COG0559@2|Bacteria,1G3S0@1117|Cyanobacteria,1H45Q@1129|Synechococcus	1117|Cyanobacteria	P	Hydrophobic amino acid ABC transporter (HAAT) family, permease protein	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7700831_0	1122919.KB905552_gene519	1.828e-84	287.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,4HCKQ@91061|Bacilli,26SXB@186822|Paenibacillaceae	91061|Bacilli	E	Arginase family	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_7712346_1	1297742.A176_01286	2.683e-228	713.0	COG0538@1|root,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,42M56@68525|delta/epsilon subdivisions,2WJ8W@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM isocitrate isopropylmalate dehydrogenase	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_7712346_0	483219.LILAB_25565	9.76e-242	751.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,42N8U@68525|delta/epsilon subdivisions,2WJAN@28221|Deltaproteobacteria,2YYIW@29|Myxococcales	28221|Deltaproteobacteria	H	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_7716914_5	1047013.AQSP01000117_gene631	1.834e-87	302.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	cyoE	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	ATPase_2
HKD1_k127_7716914_6	671143.DAMO_2532	1.366e-50	186.0	COG0242@1|root,COG0242@2|Bacteria,2NPNH@2323|unclassified Bacteria	2|Bacteria	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	GO:0003674,GO:0003824,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018206,GO:0019538,GO:0031365,GO:0036211,GO:0042586,GO:0043170,GO:0043412,GO:0043686,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0071704,GO:1901564	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD1_k127_7716914_1	671143.DAMO_2531	1.581e-117	387.0	COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Peptidase_M22
HKD1_k127_7716914_0	671143.DAMO_2530	7.072e-176	565.0	COG0793@1|root,COG0793@2|Bacteria,2NNVZ@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD1_k127_7716914_2	671143.DAMO_2529	1.362e-102	348.0	COG4942@1|root,COG4942@2|Bacteria,2NPDY@2323|unclassified Bacteria	2|Bacteria	D	Peptidase family M23	envC	GO:0000920,GO:0001896,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008219,GO:0009273,GO:0009314,GO:0009628,GO:0009987,GO:0012501,GO:0016020,GO:0016787,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0042546,GO:0042597,GO:0043085,GO:0044085,GO:0044093,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071554,GO:0071840,GO:0071944	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD1_k127_7716914_3	671143.DAMO_2528	7.124e-94	316.0	COG2177@1|root,COG2177@2|Bacteria,2NPIM@2323|unclassified Bacteria	2|Bacteria	D	Belongs to the ABC-4 integral membrane protein family. FtsX subfamily	ftsX	GO:0000910,GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006928,GO:0007049,GO:0007154,GO:0007165,GO:0007166,GO:0008150,GO:0008356,GO:0009274,GO:0009276,GO:0009605,GO:0009607,GO:0009615,GO:0009966,GO:0009987,GO:0010033,GO:0010646,GO:0016020,GO:0016021,GO:0016043,GO:0019221,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0023052,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0032153,GO:0032506,GO:0034097,GO:0040007,GO:0040011,GO:0042173,GO:0042221,GO:0043207,GO:0043937,GO:0043938,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0048518,GO:0048522,GO:0048583,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051179,GO:0051301,GO:0051674,GO:0051704,GO:0051707,GO:0051716,GO:0065007,GO:0070098,GO:0070297,GO:0070887,GO:0071310,GO:0071345,GO:0071840,GO:0071944,GO:0071976,GO:0090529,GO:1902531	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD1_k127_7716914_4	671143.DAMO_2527	2.27e-88	304.0	COG2884@1|root,COG2884@2|Bacteria,2NP95@2323|unclassified Bacteria	2|Bacteria	D	ATPases associated with a variety of cellular activities	ftsE	GO:0000166,GO:0000287,GO:0000910,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0007049,GO:0008144,GO:0008150,GO:0008356,GO:0009898,GO:0009966,GO:0009987,GO:0010646,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019897,GO:0019898,GO:0022402,GO:0022603,GO:0022607,GO:0023051,GO:0030145,GO:0030554,GO:0031234,GO:0032153,GO:0032506,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042173,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043937,GO:0043938,GO:0044085,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0045595,GO:0045597,GO:0045881,GO:0046677,GO:0046872,GO:0046914,GO:0048518,GO:0048522,GO:0048583,GO:0050789,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051301,GO:0065007,GO:0070297,GO:0071840,GO:0071944,GO:0090529,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1902531	-	ko:K09811,ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD1_k127_7716914_7	1121920.AUAU01000025_gene2342	1.346e-10	70.0	COG0726@1|root,COG0726@2|Bacteria,3Y4FK@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_7721767_2	1051632.TPY_3593	1.358e-36	142.0	COG2197@1|root,COG2197@2|Bacteria,1TRXG@1239|Firmicutes,24FZX@186801|Clostridia,3WDBM@538999|Clostridiales incertae sedis	186801|Clostridia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7721767_0	396588.Tgr7_0672	2.719e-87	314.0	COG2114@1|root,COG2114@2|Bacteria,1MV1V@1224|Proteobacteria,1SZ0N@1236|Gammaproteobacteria,1X2J4@135613|Chromatiales	135613|Chromatiales	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc,HAMP
HKD1_k127_7721767_3	1137268.AZXF01000040_gene3328	2.47e-16	85.0	COG2026@1|root,COG2026@2|Bacteria	2|Bacteria	DJ	nuclease activity	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_7721767_1	644282.Deba_0308	1.089e-53	194.0	COG0500@1|root,COG0500@2|Bacteria	2|Bacteria	Q	methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2,Methyltransf_25
HKD1_k127_7744086_1	1499967.BAYZ01000136_gene58	3.802e-115	387.0	COG1003@1|root,COG1003@2|Bacteria,2NNSG@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,GDC-P
HKD1_k127_7744086_0	671143.DAMO_0706	6.626e-179	571.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD1_k127_7744086_2	292459.STH1921	1.43e-29	120.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD1_k127_7766797_0	584708.Apau_0089	8.289e-143	480.0	COG0574@1|root,COG3848@1|root,COG0574@2|Bacteria,COG3848@2|Bacteria,3TAJY@508458|Synergistetes	508458|Synergistetes	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_7766797_1	1267535.KB906767_gene2015	7.547e-37	143.0	COG2801@1|root,COG2801@2|Bacteria,3Y821@57723|Acidobacteria	57723|Acidobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve_3
HKD1_k127_7783945_4	1192034.CAP_7115	1.725e-46	173.0	COG0240@1|root,COG0240@2|Bacteria	2|Bacteria	I	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD1_k127_7783945_0	1499967.BAYZ01000068_gene1928	5.029e-185	588.0	COG1653@1|root,COG1653@2|Bacteria,2NPYG@2323|unclassified Bacteria	2|Bacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K05813	ko02010,map02010	M00198	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.3	-	-	SBP_bac_8
HKD1_k127_7783945_2	1499967.BAYZ01000068_gene1927	4.132e-117	385.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	ugpA	-	-	ko:K02025,ko:K05814,ko:K15771	ko02010,map02010	M00198,M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2,3.A.1.1.3	-	-	BPD_transp_1
HKD1_k127_7783945_1	1499967.BAYZ01000068_gene1926	1.709e-136	439.0	COG0395@1|root,COG0395@2|Bacteria,2NPII@2323|unclassified Bacteria	2|Bacteria	G	PFAM binding-protein-dependent transport systems inner membrane component	ugpE	-	-	ko:K02026,ko:K05815	ko02010,map02010	M00198,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.3	-	-	BPD_transp_1
HKD1_k127_7783945_5	671143.DAMO_3057	9.414e-41	159.0	COG2885@1|root,COG2885@2|Bacteria,2NPMV@2323|unclassified Bacteria	2|Bacteria	M	OmpA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD1_k127_7783945_3	266117.Rxyl_0232	1.263e-49	194.0	COG0586@1|root,COG0671@1|root,COG0586@2|Bacteria,COG0671@2|Bacteria,2IE8G@201174|Actinobacteria,4CPJ4@84995|Rubrobacteria	84995|Rubrobacteria	I	SNARE associated Golgi protein	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
HKD1_k127_7823775_13	1382304.JNIL01000001_gene3204	1.69e-57	207.0	COG2041@1|root,COG2041@2|Bacteria,1V1P9@1239|Firmicutes,4HFQC@91061|Bacilli,278B0@186823|Alicyclobacillaceae	91061|Bacilli	S	Oxidoreductase molybdopterin binding domain	yuiH	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HKD1_k127_7823775_15	240015.ACP_3529	1.668e-42	164.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_7823775_19	1267534.KB906760_gene1563	7.717e-08	57.0	29A7N@1|root,2ZX8K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7823775_1	1210884.HG799463_gene9619	4.132e-157	530.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_7823775_14	644282.Deba_0317	2.217e-50	189.0	COG1102@1|root,COG1102@2|Bacteria,1R4GX@1224|Proteobacteria,42QKV@68525|delta/epsilon subdivisions,2WJS2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_7823775_3	1118054.CAGW01000050_gene1263	1.018e-109	371.0	COG0683@1|root,COG0683@2|Bacteria,1V4XA@1239|Firmicutes,4I77Z@91061|Bacilli,272NN@186822|Paenibacillaceae	91061|Bacilli	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_7823775_7	1243664.CAVL020000009_gene655	2.915e-89	304.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,4HBFZ@91061|Bacilli,1ZBPA@1386|Bacillus	91061|Bacilli	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K11960	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD1_k127_7823775_6	1118054.CAGW01000050_gene1265	2.507e-91	324.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,4HBB8@91061|Bacilli,272J5@186822|Paenibacillaceae	91061|Bacilli	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_7823775_9	1243664.CAVL020000009_gene657	3.132e-76	262.0	COG0411@1|root,COG0411@2|Bacteria,1TRME@1239|Firmicutes,4I2QY@91061|Bacilli,1ZMTA@1386|Bacillus	91061|Bacilli	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7823775_8	370438.PTH_0462	1.606e-87	295.0	COG0410@1|root,COG0410@2|Bacteria,1U9ET@1239|Firmicutes,249MH@186801|Clostridia,260RJ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_7823775_11	420246.GTNG_2361	8.711e-67	239.0	COG0667@1|root,COG0667@2|Bacteria,1UKPC@1239|Firmicutes,4HCF8@91061|Bacilli,1WETG@129337|Geobacillus	91061|Bacilli	C	Aldo/keto reductase family	tas	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_7823775_16	240016.ABIZ01000001_gene5808	2.224e-19	93.0	COG2010@1|root,COG2010@2|Bacteria,46TBB@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_7823775_10	688269.Theth_1333	2.102e-70	248.0	COG0253@1|root,COG0253@2|Bacteria	2|Bacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008837,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016020,GO:0016053,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0036361,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0047661,GO:0071704,GO:0071944,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	iIT341.HP0566,iLJ478.TM1522	DAP_epimerase
HKD1_k127_7823775_5	329726.AM1_1636	4.478e-96	327.0	COG2515@1|root,COG2515@2|Bacteria,1GFIB@1117|Cyanobacteria	1117|Cyanobacteria	E	1-aminocyclopropane-1-carboxylate deaminase	-	-	3.5.99.7,4.4.1.15	ko:K01505,ko:K05396	ko00270,map00270	-	R00997,R01874	RC00382,RC00419	ko00000,ko00001,ko01000	-	-	-	PALP
HKD1_k127_7823775_12	649831.L083_2112	1.659e-66	236.0	COG0410@1|root,COG0410@2|Bacteria,2GKSQ@201174|Actinobacteria,4D9QU@85008|Micromonosporales	201174|Actinobacteria	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	livF	-	-	ko:K01995,ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7823775_0	1304874.JAFY01000005_gene1657	1.371e-163	536.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,3TAPS@508458|Synergistetes	508458|Synergistetes	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD1_k127_7823775_4	1304874.JAFY01000005_gene1656	8.413e-106	352.0	COG0559@1|root,COG0559@2|Bacteria,3TA5X@508458|Synergistetes	508458|Synergistetes	E	transport system permease	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7823775_2	1449126.JQKL01000040_gene1084	2.56e-136	448.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_7823775_21	338966.Ppro_2662	0.000801	49.0	COG3678@1|root,COG3678@2|Bacteria,1RBDH@1224|Proteobacteria	1224|Proteobacteria	NPTU	P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein	-	-	-	ko:K06006	-	-	-	-	ko00000,ko03110	-	-	-	LTXXQ,Metal_resist
HKD1_k127_7823775_17	891968.Anamo_1250	7.453e-19	89.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	tetB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K08168	-	M00704	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3.16,2.A.1.3.22,2.A.1.3.6	-	-	MFS_1,Sugar_tr
HKD1_k127_7868807_4	1340493.JNIF01000003_gene1752	1.353e-50	190.0	COG0436@1|root,COG0436@2|Bacteria	2|Bacteria	E	Aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_7868807_2	1444309.JAQG01000004_gene3669	3.799e-87	307.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,4HAM7@91061|Bacilli,26TIQ@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter substrate-binding protein	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_7868807_0	479434.Sthe_0306	5.811e-140	458.0	COG0001@1|root,COG0001@2|Bacteria,2G7UK@200795|Chloroflexi,27XN6@189775|Thermomicrobia	189775|Thermomicrobia	H	Aminotransferase class-III	-	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7868807_1	69279.BG36_15290	3.541e-92	312.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,2TT48@28211|Alphaproteobacteria,43R36@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	U	transport systems	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_7868807_3	1444309.JAQG01000017_gene751	1.634e-80	278.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,4HDBB@91061|Bacilli,274T8@186822|Paenibacillaceae	91061|Bacilli	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_7892180_4	1489678.RDMS_09680	3.092e-10	62.0	COG2337@1|root,COG2337@2|Bacteria	2|Bacteria	T	Toxic component of a toxin-antitoxin (TA) module	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_7892180_0	102129.Lepto7375DRAFT_0678	8.724e-107	359.0	COG5421@1|root,COG5421@2|Bacteria,1G4EU@1117|Cyanobacteria,1H9I9@1150|Oscillatoriales	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_7892180_2	91464.S7335_1320	1.291e-35	139.0	COG5421@1|root,COG5421@2|Bacteria,1G4EU@1117|Cyanobacteria,1H3QR@1129|Synechococcus	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_7892180_1	402777.KB235906_gene304	1.218e-72	252.0	COG3039@1|root,COG3039@2|Bacteria,1G3IA@1117|Cyanobacteria,1HEFE@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD1_k127_7892180_3	485913.Krac_3845	1.642e-12	75.0	COG3039@1|root,COG3039@2|Bacteria,2G8AJ@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B2JC10 Transposase IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD1_k127_7953663_0	706587.Desti_0073	7.595e-50	183.0	COG1024@1|root,COG1024@2|Bacteria,1N2V7@1224|Proteobacteria,42UXR@68525|delta/epsilon subdivisions,2WQCT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_7999520_0	886293.Sinac_2162	6.981e-195	631.0	COG1570@1|root,COG1961@1|root,COG1570@2|Bacteria,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	xseA	-	3.1.11.6	ko:K03601,ko:K13582	ko03430,ko04112,map03430,map04112	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,KfrA_N,Recombinase,Resolvase,Zn_ribbon_recom,tRNA_anti_2
HKD1_k127_8010867_0	383372.Rcas_1032	5.246e-145	467.0	COG0161@1|root,COG0161@2|Bacteria,2G62N@200795|Chloroflexi,376DU@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_8010867_3	1382306.JNIM01000001_gene1387	2.861e-33	143.0	COG0665@1|root,COG0665@2|Bacteria,2G6QE@200795|Chloroflexi	200795|Chloroflexi	E	PFAM FAD dependent oxidoreductase	-	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_8010867_1	309801.trd_1862	1.223e-110	378.0	COG0747@1|root,COG0747@2|Bacteria,2G860@200795|Chloroflexi,27XM9@189775|Thermomicrobia	189775|Thermomicrobia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_8010867_2	1382356.JQMP01000004_gene623	2.876e-110	366.0	COG0601@1|root,COG0601@2|Bacteria,2G7SK@200795|Chloroflexi,27XXY@189775|Thermomicrobia	189775|Thermomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_801772_5	391008.Smal_3564	0.0003077	52.0	2EGGB@1|root,31RVV@2|Bacteria,1QJ88@1224|Proteobacteria,1TH6E@1236|Gammaproteobacteria,1XA5E@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_801772_2	1278073.MYSTI_07029	5.476e-19	95.0	28UXW@1|root,2ZH1P@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_801772_4	237368.SCABRO_04005	3.165e-09	68.0	COG0457@1|root,COG0457@2|Bacteria	237368.SCABRO_04005|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_801772_0	56780.SYN_02106	3.153e-49	183.0	2ED7H@1|root,33743@2|Bacteria,1QB7X@1224|Proteobacteria,42ZXA@68525|delta/epsilon subdivisions,2WVEQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_801772_1	370438.PTH_1831	1.942e-23	107.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,2605V@186807|Peptococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoB	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_801772_3	401526.TcarDRAFT_0898	3.985e-14	79.0	COG1664@1|root,COG1664@2|Bacteria,1VEVU@1239|Firmicutes,4H5CS@909932|Negativicutes	909932|Negativicutes	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_822671_0	1120971.AUCA01000001_gene1774	1.035e-36	143.0	COG2197@1|root,COG2197@2|Bacteria,1V407@1239|Firmicutes,4HAUN@91061|Bacilli,279SU@186823|Alicyclobacillaceae	91061|Bacilli	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_822671_3	84531.JMTZ01000041_gene656	7.904e-14	79.0	COG2197@1|root,COG2197@2|Bacteria,1PE3G@1224|Proteobacteria,1SKP6@1236|Gammaproteobacteria,1XATF@135614|Xanthomonadales	135614|Xanthomonadales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_822671_1	518766.Rmar_1697	1.721e-14	80.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,4PEF0@976|Bacteroidetes,1FJ0D@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_822671_2	883126.HMPREF9710_02354	4.866e-14	77.0	COG2199@1|root,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria	1224|Proteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS,PAS_4,Response_reg
HKD1_k127_869371_2	485913.Krac_11000	8.172e-25	109.0	COG1609@1|root,COG1609@2|Bacteria	2|Bacteria	K	purine nucleotide biosynthetic process	-	-	5.3.1.12	ko:K01812,ko:K02529,ko:K16210	ko00040,ko01100,map00040,map01100	M00061,M00631	R01482,R01983	RC00376	ko00000,ko00001,ko00002,ko01000,ko02000,ko03000	2.A.2.5	-	-	DDE_Tnp_ISAZ013,Peripla_BP_3
HKD1_k127_869371_3	298653.Franean1_3065	2.817e-09	64.0	COG3415@1|root,COG3415@2|Bacteria,2I3BN@201174|Actinobacteria	201174|Actinobacteria	L	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013,HTH_Tnp_4
HKD1_k127_869371_1	886293.Sinac_6895	1.328e-169	544.0	COG0845@1|root,COG0845@2|Bacteria,2IYKR@203682|Planctomycetes	203682|Planctomycetes	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_869371_0	1210884.HG799462_gene7837	0.0	1696.0	COG0841@1|root,COG0841@2|Bacteria,2IX2G@203682|Planctomycetes	203682|Planctomycetes	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_870969_12	671143.DAMO_2898	1.134e-32	139.0	COG1426@1|root,COG1426@2|Bacteria,2NQ7E@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD1_k127_870969_7	562970.Btus_2586	5.826e-74	253.0	COG2316@1|root,COG2316@2|Bacteria,1TSF7@1239|Firmicutes,4HTP0@91061|Bacilli,279M4@186823|Alicyclobacillaceae	91061|Bacilli	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_870969_10	671143.DAMO_1549	9.273e-49	180.0	COG0782@1|root,COG0782@2|Bacteria,2NPT2@2323|unclassified Bacteria	2|Bacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	GO:0001098,GO:0001108,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006351,GO:0006354,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016020,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0030312,GO:0031323,GO:0031326,GO:0032774,GO:0032784,GO:0034641,GO:0034645,GO:0034654,GO:0042221,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071944,GO:0080090,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_870969_2	290397.Adeh_2597	7.234e-134	443.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,42MAI@68525|delta/epsilon subdivisions,2WJ8M@28221|Deltaproteobacteria,2YV5P@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_870969_1	196490.AUEZ01000010_gene2181	1.339e-142	464.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,2TQQJ@28211|Alphaproteobacteria,3JW3J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	TOBE domain	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE_2
HKD1_k127_870969_5	1499967.BAYZ01000154_gene1533	6.949e-78	267.0	COG0084@1|root,COG0084@2|Bacteria,2NP9H@2323|unclassified Bacteria	2|Bacteria	L	TatD related DNase	tatD	GO:0003674,GO:0003824,GO:0004518,GO:0004536,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_870969_0	886293.Sinac_4737	3.588e-179	580.0	COG1164@1|root,COG1164@2|Bacteria,2IWWZ@203682|Planctomycetes	203682|Planctomycetes	E	oligoendopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD1_k127_870969_4	671143.DAMO_2922	2.458e-111	371.0	COG1562@1|root,COG1562@2|Bacteria,2NQ18@2323|unclassified Bacteria	2|Bacteria	I	Squalene/phytoene synthase	crtB	GO:0003674,GO:0003824,GO:0004337,GO:0004659,GO:0006629,GO:0006720,GO:0006721,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016108,GO:0016109,GO:0016114,GO:0016116,GO:0016117,GO:0016740,GO:0016765,GO:0016767,GO:0042440,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0046148,GO:0071704,GO:1901576	2.5.1.21,2.5.1.32,2.5.1.96,2.5.1.99	ko:K00801,ko:K02291,ko:K10208	ko00100,ko00906,ko00909,ko01062,ko01100,ko01110,ko01130,map00100,map00906,map00909,map01062,map01100,map01110,map01130	M00097	R00702,R02065,R02872,R04218,R06223,R07270,R07652,R09793,R10177	RC00362,RC00796,RC01101,RC02839,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD1_k127_870969_11	1320556.AVBP01000030_gene171	1.799e-39	151.0	COG0346@1|root,COG0346@2|Bacteria,1RIN8@1224|Proteobacteria,2U9WM@28211|Alphaproteobacteria,43K76@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	bleomycin resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_870969_3	429009.Adeg_0960	2.013e-115	386.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,42FCV@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_870969_6	562970.Btus_2604	3.844e-76	265.0	COG1028@1|root,COG1028@2|Bacteria,1TRVE@1239|Firmicutes,4HCFY@91061|Bacilli,27AT7@186823|Alicyclobacillaceae	91061|Bacilli	IQ	KR domain	fabL	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004318,GO:0005488,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016627,GO:0016628,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0022607,GO:0030497,GO:0032787,GO:0036094,GO:0043436,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0046394,GO:0048037,GO:0050661,GO:0050662,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0072330,GO:0097159,GO:1901265,GO:1901363,GO:1901576	1.3.1.104	ko:K10780	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R01404,R04430,R04725,R04956,R04959,R04962,R04967,R04970	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_870969_15	1384049.CD29_01955	1.796e-22	104.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,4HGX1@91061|Bacilli,3IXTG@400634|Lysinibacillus	91061|Bacilli	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_870969_16	1463825.JNXC01000008_gene1140	2.052e-08	66.0	COG0236@1|root,COG0236@2|Bacteria,2INV8@201174|Actinobacteria,4EBM1@85010|Pseudonocardiales	201174|Actinobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD1_k127_870969_8	479434.Sthe_0375	9.04e-69	243.0	COG1028@1|root,COG1028@2|Bacteria,2G5KB@200795|Chloroflexi,27XUY@189775|Thermomicrobia	189775|Thermomicrobia	IQ	PFAM short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_870969_9	1121472.AQWN01000002_gene2335	2.111e-54	208.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,2602N@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_870969_17	270374.MELB17_17143	0.0002068	51.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,466WK@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0008150,GO:0008152,GO:0008610,GO:0008693,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0019171,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0047451,GO:0071704,GO:0072330,GO:1901576	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iJN746.PP_1602	FabA
HKD1_k127_870969_13	749414.SBI_02604	4.805e-27	117.0	COG0736@1|root,COG0736@2|Bacteria,2IPP4@201174|Actinobacteria	201174|Actinobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	-	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_870969_14	1304874.JAFY01000005_gene1319	5.907e-23	106.0	2DAQZ@1|root,32TW0@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1571)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1571
HKD1_k127_875950_2	1210884.HG799475_gene15269	2.113e-73	249.0	COG0033@1|root,COG0033@2|Bacteria,2IYG0@203682|Planctomycetes	203682|Planctomycetes	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_875950_0	196490.AUEZ01000002_gene4236	1.011e-175	556.0	COG0176@1|root,COG0176@2|Bacteria,1N9G3@1224|Proteobacteria,2U10P@28211|Alphaproteobacteria,3JWNC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_875950_1	1040989.AWZU01000008_gene3774	2.653e-99	329.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2TSPZ@28211|Alphaproteobacteria,3JRYQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_875950_3	323848.Nmul_A0469	3.672e-34	138.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2VHR9@28216|Betaproteobacteria,371Q3@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_886467_1	404589.Anae109_3985	1.528e-10	64.0	COG1483@1|root,COG1483@2|Bacteria,1PI9J@1224|Proteobacteria,43EZV@68525|delta/epsilon subdivisions,2WYKT@28221|Deltaproteobacteria,2Z2EW@29|Myxococcales	28221|Deltaproteobacteria	S	ATPase (AAA superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_886467_0	296591.Bpro_2539	6.12e-111	375.0	COG3385@1|root,COG3385@2|Bacteria,1MVRM@1224|Proteobacteria,2VNBZ@28216|Betaproteobacteria,4AD8C@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_886685_1	671143.DAMO_0005	7.565e-85	288.0	COG0612@1|root,COG0612@2|Bacteria,2NP50@2323|unclassified Bacteria	2|Bacteria	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_886685_0	671143.DAMO_0004	2.725e-122	407.0	COG0612@1|root,COG0612@2|Bacteria,2NPE5@2323|unclassified Bacteria	2|Bacteria	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_886685_2	264462.Bd3611	2.332e-09	64.0	29WX2@1|root,30IJ3@2|Bacteria,1Q0W8@1224|Proteobacteria,433PA@68525|delta/epsilon subdivisions,2WXEY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
HKD1_k127_906767_6	1238182.C882_1419	7.883e-84	287.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,2JR8D@204441|Rhodospirillales	204441|Rhodospirillales	T	Universal stress protein UspA	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_906767_2	1336243.JAEA01000010_gene3537	1.803e-155	509.0	COG0028@1|root,COG0028@2|Bacteria,1MX6Q@1224|Proteobacteria,2TS3K@28211|Alphaproteobacteria,1JRKY@119045|Methylobacteriaceae	28211|Alphaproteobacteria	EH	Belongs to the TPP enzyme family	mdlC	-	4.1.1.7	ko:K01576	ko00627,ko01120,map00627,map01120	-	R01764,R02672	RC00595	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_906767_5	1123508.JH636439_gene1018	1.869e-91	310.0	COG3391@1|root,COG3391@2|Bacteria,2J27D@203682|Planctomycetes	203682|Planctomycetes	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD1_k127_906767_7	667121.ET1_10_01020	4.102e-58	214.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,1RMXB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EG	of the drug metabolite transporter (DMT) superfamily	yddG	GO:0003333,GO:0003674,GO:0005215,GO:0005302,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006820,GO:0006855,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0015075,GO:0015171,GO:0015173,GO:0015179,GO:0015192,GO:0015196,GO:0015238,GO:0015318,GO:0015711,GO:0015801,GO:0015807,GO:0015823,GO:0015827,GO:0015828,GO:0015849,GO:0015893,GO:0016020,GO:0022857,GO:0034220,GO:0042221,GO:0042493,GO:0044464,GO:0046942,GO:0046943,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098655,GO:0098656,GO:1902475,GO:1903825,GO:1905039	-	-	-	-	-	-	-	-	-	iBWG_1329.BWG_1294,iE2348C_1286.E2348C_1607,iECDH10B_1368.ECDH10B_1604,iECDH1ME8569_1439.ECDH1ME8569_1416,iECS88_1305.ECS88_1565,iEcDH1_1363.EcDH1_2175,iJO1366.b1473,iNRG857_1313.NRG857_07295,iSSON_1240.SSON_1651,iUMN146_1321.UM146_09675	EamA
HKD1_k127_906767_1	706587.Desti_1056	9.691e-189	599.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	EF-hand_7,Pyridoxal_deC
HKD1_k127_906767_4	1410620.SHLA_2c002430	2.336e-127	417.0	COG1149@1|root,COG1149@2|Bacteria,1QTYV@1224|Proteobacteria,2TTH3@28211|Alphaproteobacteria,4BDG7@82115|Rhizobiaceae	28211|Alphaproteobacteria	C	TIGRFAM CitB domain protein	tcuB	-	-	ko:K13795	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_906767_0	1298867.AUES01000010_gene5862	3.047e-205	649.0	COG1053@1|root,COG1053@2|Bacteria,1MX5A@1224|Proteobacteria,2TV7T@28211|Alphaproteobacteria,3JQYS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	FAD dependent oxidoreductase	cobZ	-	-	ko:K13796	-	-	-	-	ko00000	-	-	-	FAD_binding_2
HKD1_k127_906767_3	1382306.JNIM01000001_gene3130	5.944e-146	468.0	COG0028@1|root,COG0028@2|Bacteria,2G5Q7@200795|Chloroflexi	2|Bacteria	H	Thiamine pyrophosphate protein TPP binding domain protein	ilvB2	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_928880_1	1380394.JADL01000010_gene4354	4.085e-100	335.0	COG0596@1|root,COG0596@2|Bacteria,1NJ2B@1224|Proteobacteria,2TR54@28211|Alphaproteobacteria,2JV21@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_928880_2	1449063.JMLS01000007_gene3546	5.532e-30	129.0	COG3619@1|root,COG3619@2|Bacteria,1VBZN@1239|Firmicutes,4HMQK@91061|Bacilli,26YPB@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1275)	yoaK	-	-	-	-	-	-	-	-	-	-	-	DUF1275
HKD1_k127_928880_0	1499967.BAYZ01000076_gene816	1.867e-119	389.0	COG1064@1|root,COG1064@2|Bacteria,2NP06@2323|unclassified Bacteria	2|Bacteria	S	Alcohol dehydrogenase GroES-like domain	adhA	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_93303_1	344747.PM8797T_28219	4.241e-114	381.0	COG1846@1|root,COG1846@2|Bacteria,2J00N@203682|Planctomycetes	203682|Planctomycetes	K	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
HKD1_k127_93303_2	1255043.TVNIR_3529	2.46e-61	221.0	2FFXP@1|root,347UK@2|Bacteria,1P1PS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_93303_5	1123242.JH636434_gene4371	6.516e-10	68.0	2FINY@1|root,34AER@2|Bacteria,2J3UH@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_93303_3	32057.KB217483_gene9954	4.399e-42	169.0	2E6C0@1|root,330ZT@2|Bacteria,1G6AK@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_93303_0	344747.PM8797T_28114	3.965e-160	521.0	COG4974@1|root,COG4974@2|Bacteria,2IXH0@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
HKD1_k127_93303_4	314230.DSM3645_28137	6.986e-30	125.0	COG3436@1|root,COG3436@2|Bacteria,2J11P@203682|Planctomycetes	203682|Planctomycetes	L	PFAM IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
HKD1_k127_97709_6	398525.KB900701_gene7500	4.843e-111	368.0	COG0074@1|root,COG0074@2|Bacteria,1MX67@1224|Proteobacteria,2U0AT@28211|Alphaproteobacteria,3JX2B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Protein of unknown function (DUF1116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1116
HKD1_k127_97709_14	1532557.JL37_01920	2.086e-69	254.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VJHF@28216|Betaproteobacteria,3T5IN@506|Alcaligenaceae	28216|Betaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_97709_3	504832.OCAR_7472	4.901e-125	432.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3JRTU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	livG2	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD1_k127_97709_13	419610.Mext_3367	5.583e-70	250.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,1JTGH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_97709_2	118161.KB235922_gene1298	1.046e-136	450.0	COG0683@1|root,COG0683@2|Bacteria,1G1VZ@1117|Cyanobacteria	1117|Cyanobacteria	E	Receptor family ligand binding region	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_6
HKD1_k127_97709_0	1380387.JADM01000001_gene121	3.026e-209	668.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XJ17@135619|Oceanospirillales	135619|Oceanospirillales	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_97709_9	696369.KI912183_gene1366	4.628e-90	304.0	COG1028@1|root,COG1028@2|Bacteria,1TQ3V@1239|Firmicutes,24ARQ@186801|Clostridia	186801|Clostridia	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD1_k127_97709_15	1125863.JAFN01000001_gene907	4.469e-49	193.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,42SN2@68525|delta/epsilon subdivisions,2WPT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family	kdsC	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD1_k127_97709_4	338963.Pcar_1943	1.414e-120	402.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,42M0M@68525|delta/epsilon subdivisions,2WJ4Y@28221|Deltaproteobacteria,43S6C@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	SIS domain	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iAF987.Gmet_1278	CBS,SIS
HKD1_k127_97709_7	1232410.KI421421_gene3582	1.095e-98	331.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,42M61@68525|delta/epsilon subdivisions,2WIXU@28221|Deltaproteobacteria,43T9N@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	DAHP synthetase I family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD1_k127_97709_12	1116232.AHBF01000007_gene1485	4.371e-70	243.0	COG0652@1|root,COG0652@2|Bacteria,2IFUE@201174|Actinobacteria	201174|Actinobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	cypB	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_97709_8	644966.Tmar_0675	5.496e-97	326.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,3WCRM@538999|Clostridiales incertae sedis	186801|Clostridia	M	MobA-like NTP transferase domain	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_97709_5	1396418.BATQ01000049_gene383	1.317e-114	383.0	COG1577@1|root,COG1577@2|Bacteria,46V85@74201|Verrucomicrobia	74201|Verrucomicrobia	I	mevalonate kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_97709_11	574087.Acear_0946	1.865e-76	272.0	COG0407@1|root,COG0407@2|Bacteria,1V4WM@1239|Firmicutes,25N8F@186801|Clostridia,3WBM2@53433|Halanaerobiales	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_97709_17	522306.CAP2UW1_2634	2.379e-31	130.0	COG5608@1|root,COG5608@2|Bacteria,1N6YX@1224|Proteobacteria,2WFZ1@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SMART Water Stress and Hypersensitive response	-	-	-	-	-	-	-	-	-	-	-	-	LEA_2
HKD1_k127_97709_16	1163617.SCD_n02328	1.475e-40	154.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2VSE7@28216|Betaproteobacteria	28216|Betaproteobacteria	J	chain release factor	yaeJ	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD1_k127_97709_10	1167006.UWK_00713	3.707e-82	282.0	COG2519@1|root,COG2519@2|Bacteria,1QU0A@1224|Proteobacteria,43BUT@68525|delta/epsilon subdivisions,2X75U@28221|Deltaproteobacteria,2MPKK@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Spermidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_97709_1	1288494.EBAPG3_1080	4.733e-178	567.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria,372CT@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Protein of unknown function (DUF3417)	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_995451_1	56780.SYN_01528	1.756e-46	171.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,42RRV@68525|delta/epsilon subdivisions,2WNKH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_995451_0	56780.SYN_01529	1.512e-116	388.0	COG2239@1|root,COG2239@2|Bacteria,1RFCV@1224|Proteobacteria,42S1B@68525|delta/epsilon subdivisions,2WP0D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	MgtE intracellular	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
## 5137 queries scanned
## Total time (seconds): 242.54786157608032
## Rate: 21.18 q/s