## Fri Nov 15 11:59:50 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin8/HKD_1_bin.55.fa -m mmseqs --itype genome -o HKD_1_bin.55 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_1_bin.55 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1014383_1	1158182.KB905020_gene1774	2.334e-103	344.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,1RQ57@1236|Gammaproteobacteria,1WZYG@135613|Chromatiales	135613|Chromatiales	G	Fructose-bisphosphate aldolase class-I	-	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HKD1_k127_1014383_4	240016.ABIZ01000001_gene5373	7.785e-33	137.0	COG0730@1|root,COG0730@2|Bacteria	2|Bacteria	S	response to heat	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_1014383_2	1437425.CSEC_1842	5.147e-83	286.0	COG0121@1|root,COG0121@2|Bacteria,2JG9A@204428|Chlamydiae	204428|Chlamydiae	S	Glutamine amidotransferases class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HKD1_k127_1014383_5	936136.ARRT01000007_gene1152	5.7e-07	53.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,4B7RZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Cation transport ATPase	actP	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD1_k127_1014383_3	1210884.HG799464_gene10983	1.591e-58	214.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	YHS
HKD1_k127_1014383_7	478741.JAFS01000002_gene163	2.182e-06	57.0	2BFVZ@1|root,329RE@2|Bacteria,46ZG6@74201|Verrucomicrobia,37H0W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1014383_6	478741.JAFS01000002_gene163	7.25e-07	55.0	2BFVZ@1|root,329RE@2|Bacteria,46ZG6@74201|Verrucomicrobia,37H0W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1014383_0	452637.Oter_4427	1.678e-125	408.0	COG0058@1|root,COG0058@2|Bacteria,46TZP@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Carbohydrate phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_10189_1	517418.Ctha_1864	1.766e-33	133.0	COG0493@1|root,COG0493@2|Bacteria,1FDAT@1090|Chlorobi	1090|Chlorobi	C	TIGRFAM glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_10189_0	338963.Pcar_0753	5.733e-91	309.0	COG0543@1|root,COG0543@2|Bacteria,1NTWI@1224|Proteobacteria,42M66@68525|delta/epsilon subdivisions,2WJJ2@28221|Deltaproteobacteria,43U7N@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	oxidoreductase FAD NAD(P)-binding domain protein	nfnB	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HKD1_k127_10189_2	404589.Anae109_1054	1.374e-21	106.0	COG1018@1|root,COG1018@2|Bacteria,1R5FN@1224|Proteobacteria	1224|Proteobacteria	C	Oxidoreductase FAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
HKD1_k127_10189_3	1303518.CCALI_01224	3.753e-05	54.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456,ko:K02679	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
HKD1_k127_1053652_14	1292034.OR37_02619	1.188e-17	95.0	COG3591@1|root,COG3591@2|Bacteria,1R9P2@1224|Proteobacteria,2U37F@28211|Alphaproteobacteria,2KF5Z@204458|Caulobacterales	204458|Caulobacterales	E	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_1053652_2	670292.JH26_17415	2.231e-148	479.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2U2PN@28211|Alphaproteobacteria,1JWZ2@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD1_k127_1053652_4	118163.Ple7327_1621	2.829e-93	315.0	COG0462@1|root,COG0462@2|Bacteria,1G00F@1117|Cyanobacteria,3VHW2@52604|Pleurocapsales	1117|Cyanobacteria	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD1_k127_1053652_6	497964.CfE428DRAFT_3249	1.616e-84	289.0	COG2169@1|root,COG4936@1|root,COG2169@2|Bacteria,COG4936@2|Bacteria,46UZR@74201|Verrucomicrobia	74201|Verrucomicrobia	K	PFAM helix-turn-helix- domain containing protein AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,PocR
HKD1_k127_1053652_10	247490.KSU1_A0074	2.568e-36	146.0	COG0664@1|root,COG0664@2|Bacteria,2J0N9@203682|Planctomycetes	203682|Planctomycetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_1053652_12	1191523.MROS_2770	6.036e-25	112.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	usp-3	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1053652_5	1396141.BATP01000039_gene1324	2.559e-89	301.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia,2ITGC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_1053652_15	224324.aq_2194	4.143e-17	90.0	COG1999@1|root,COG1999@2|Bacteria	2|Bacteria	M	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_1053652_0	925409.KI911562_gene954	8.093e-206	654.0	COG0843@1|root,COG0843@2|Bacteria,4P06K@976|Bacteroidetes	976|Bacteroidetes	C	Cytochrome C oxidase subunit I	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_1053652_16	869210.Marky_2012	1.515e-15	87.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	soxX	-	1.9.3.1	ko:K02275,ko:K17223	ko00190,ko00920,ko01100,ko01120,map00190,map00920,map01100,map01120	M00155,M00595	R00081,R10151	RC00016,RC03151,RC03152	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cytochrom_C
HKD1_k127_1053652_9	638303.Thal_1573	7.959e-47	179.0	COG1622@1|root,COG1622@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor	cbaB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2-transmemb
HKD1_k127_1053652_7	1379698.RBG1_1C00001G0779	1.437e-71	265.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD1_k127_1053652_3	1379698.RBG1_1C00001G0780	1.987e-106	361.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HKD1_k127_1053652_13	1379698.RBG1_1C00001G0781	1.014e-17	89.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HKD1_k127_1053652_17	523791.Kkor_1288	8.052e-08	64.0	COG2010@1|root,COG2010@2|Bacteria,1RFJV@1224|Proteobacteria,1S4GY@1236|Gammaproteobacteria,1XPKF@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_1053652_8	671143.DAMO_0769	1.05e-59	224.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	pcmF	-	-	ko:K02305	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002	3.D.4.10	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_1053652_1	234267.Acid_3505	2.897e-150	486.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petB	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD1_k127_1053652_11	290397.Adeh_2405	8.806e-35	138.0	COG0723@1|root,COG0723@2|Bacteria,1NINP@1224|Proteobacteria,42VKD@68525|delta/epsilon subdivisions	1224|Proteobacteria	C	PFAM Rieske 2Fe-2S domain	pcmE	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HKD1_k127_1054411_1	671143.DAMO_2943	7.601e-104	346.0	COG0451@1|root,COG0451@2|Bacteria,2NPSM@2323|unclassified Bacteria	2|Bacteria	GM	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008712,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016853,GO:0016854,GO:0016857,GO:0033692,GO:0034637,GO:0034645,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0048037,GO:0050661,GO:0050662,GO:0070401,GO:0071704,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901363,GO:1901576,GO:1903509	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iPC815.YPO0058,iYL1228.KPN_03963	Epimerase
HKD1_k127_1054411_3	338963.Pcar_0454	1.35e-94	334.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,43BRF@68525|delta/epsilon subdivisions,2WKAH@28221|Deltaproteobacteria,43TV7@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	TonB dependent receptor	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD1_k127_1054411_2	204669.Acid345_1478	1.343e-101	339.0	COG0345@1|root,COG0345@2|Bacteria,3Y41B@57723|Acidobacteria,2JITZ@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD1_k127_1054411_0	1454004.AW11_00555	7.123e-117	389.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2VJVZ@28216|Betaproteobacteria,1KPQ8@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	S	DNA recombination protein RmuC	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD1_k127_1054411_4	497964.CfE428DRAFT_1722	1.424e-77	265.0	COG1028@1|root,COG1028@2|Bacteria,46V2S@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_1054411_5	1121129.KB903367_gene2833	1.963e-31	124.0	COG0491@1|root,COG0491@2|Bacteria,4NE2Y@976|Bacteroidetes,2FSQ1@200643|Bacteroidia,22XXM@171551|Porphyromonadaceae	976|Bacteroidetes	P	metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_1061579_4	330214.NIDE1927	8.869e-25	113.0	COG0589@1|root,COG0589@2|Bacteria,3J1A7@40117|Nitrospirae	40117|Nitrospirae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1061579_2	485913.Krac_9825	9.114e-33	128.0	2DJKR@1|root,32YT5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1061579_5	1537917.JU82_01515	8.166e-06	53.0	2EG21@1|root,339U1@2|Bacteria,1P2NF@1224|Proteobacteria,42X8D@68525|delta/epsilon subdivisions,2YQRR@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HKD1_k127_1061579_1	643473.KB235930_gene2821	1.939e-37	148.0	COG5502@1|root,COG5502@2|Bacteria,1G7AK@1117|Cyanobacteria,1HN9D@1161|Nostocales	1117|Cyanobacteria	S	Uncharacterized conserved protein (DUF2267)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2267
HKD1_k127_1061579_3	1479237.JMLY01000001_gene2639	5.509e-27	119.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_1061579_0	1082933.MEA186_07939	1.021e-91	306.0	COG0459@1|root,COG0459@2|Bacteria,1PMNK@1224|Proteobacteria,2TTPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_1085077_7	1122604.JONR01000004_gene851	5.627e-106	364.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_1085077_6	1122604.JONR01000004_gene851	1.022e-113	394.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_1085077_12	459495.SPLC1_S208750	9.293e-36	141.0	COG2402@1|root,COG2402@2|Bacteria,1G79E@1117|Cyanobacteria,1HBMU@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_1085077_5	1120797.KB908262_gene2997	4.937e-122	399.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Esterase,SGL
HKD1_k127_1085077_15	419947.MRA_2629A	1.018e-08	59.0	2DGZX@1|root,2ZXWY@2|Bacteria,2HDW7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1085077_16	1089550.ATTH01000001_gene1311	5.633e-06	53.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_1085077_8	1122604.JONR01000004_gene853	3.26e-99	349.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales	135614|Xanthomonadales	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1085077_3	1122603.ATVI01000005_gene3499	1.118e-129	435.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD1_k127_1085077_4	1122603.ATVI01000005_gene3498	2.429e-127	432.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SZ6C@1236|Gammaproteobacteria,1XCCV@135614|Xanthomonadales	1236|Gammaproteobacteria	T	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_19,TPR_2,TPR_8
HKD1_k127_1085077_1	64471.sync_2679	1.147e-169	548.0	COG0154@1|root,COG0154@2|Bacteria,1G0HS@1117|Cyanobacteria,1GZCX@1129|Synechococcus	1117|Cyanobacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_1085077_0	1122603.ATVI01000005_gene3499	1.687e-193	619.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9I0@135614|Xanthomonadales	135614|Xanthomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD1_k127_1085077_14	1265503.KB905166_gene652	2.961e-20	101.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1S0KQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1085077_11	1267534.KB906754_gene3444	4.098e-45	175.0	COG4319@1|root,COG4319@2|Bacteria,3Y5FP@57723|Acidobacteria,2JN7M@204432|Acidobacteriia	204432|Acidobacteriia	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_1085077_13	1123073.KB899243_gene504	7.62e-35	140.0	2AEZN@1|root,314XR@2|Bacteria,1NSHG@1224|Proteobacteria,1SMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1085077_9	1223521.BBJX01000014_gene314	2.193e-74	260.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VKYM@28216|Betaproteobacteria,4AA9N@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_1085077_10	1267533.KB906736_gene961	4.199e-51	184.0	COG1725@1|root,COG1725@2|Bacteria,3Y5VN@57723|Acidobacteria,2JK5T@204432|Acidobacteriia	2|Bacteria	K	helix_turn_helix gluconate operon transcriptional repressor	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD1_k127_1085077_2	1267533.KB906736_gene962	1.659e-133	431.0	COG1131@1|root,COG1131@2|Bacteria,3Y7BR@57723|Acidobacteria,2JKD9@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1091135_2	497964.CfE428DRAFT_2029	4.579e-93	310.0	COG0777@1|root,COG0777@2|Bacteria,46SI0@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_1091135_1	497964.CfE428DRAFT_2028	5.089e-122	405.0	COG0285@1|root,COG0285@2|Bacteria,46SKD@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Mur ligase middle domain	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_1091135_3	497964.CfE428DRAFT_2982	6.435e-16	80.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD1_k127_1091135_0	497964.CfE428DRAFT_0045	4.005e-140	454.0	COG0143@1|root,COG0143@2|Bacteria,46SCQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HKD1_k127_1096930_0	1173028.ANKO01000164_gene2746	0.0	1035.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1G1HW@1117|Cyanobacteria,1H6Y0@1150|Oscillatoriales	1117|Cyanobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD1_k127_1096930_1	497964.CfE428DRAFT_4183	1.195e-226	711.0	COG1232@1|root,COG1232@2|Bacteria,46TGR@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD1_k127_1096930_6	251229.Chro_5241	1.93e-76	272.0	COG5542@1|root,COG5542@2|Bacteria,1G4VD@1117|Cyanobacteria	1117|Cyanobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1096930_5	497964.CfE428DRAFT_3830	1.42e-93	311.0	COG0313@1|root,COG0313@2|Bacteria,46SVC@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD1_k127_1096930_2	1521187.JPIM01000056_gene2609	1.005e-164	523.0	COG1899@1|root,COG1899@2|Bacteria,2G7R7@200795|Chloroflexi,374VZ@32061|Chloroflexia	32061|Chloroflexia	O	PFAM deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD1_k127_1096930_4	1267534.KB906754_gene3770	2.31e-128	426.0	COG1007@1|root,COG1007@2|Bacteria,3Y73U@57723|Acidobacteria,2JMM8@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_1096930_3	1267534.KB906754_gene3771	7.084e-160	520.0	COG1008@1|root,COG1008@2|Bacteria,3Y6FA@57723|Acidobacteria,2JM6J@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_1156630_9	204669.Acid345_3656	1.665e-22	99.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD1_k127_1156630_5	1537715.JQFJ01000001_gene2734	7.951e-55	214.0	COG4805@1|root,COG4805@2|Bacteria,1NRZP@1224|Proteobacteria,2UNXX@28211|Alphaproteobacteria,2K9QH@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_1156630_10	221288.JH992901_gene1332	1.164e-09	63.0	COG2270@1|root,COG2270@2|Bacteria,1GQJW@1117|Cyanobacteria,1JJTH@1189|Stigonemataceae	1117|Cyanobacteria	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_1156630_4	86416.Clopa_2530	6.22e-62	220.0	COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,24ADY@186801|Clostridia,36G2E@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
HKD1_k127_1156630_0	469383.Cwoe_1088	1.74e-201	634.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_1156630_1	497964.CfE428DRAFT_3226	4.494e-176	561.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_1156630_2	448385.sce2665	2.069e-75	258.0	COG1335@1|root,COG1335@2|Bacteria,1MZP9@1224|Proteobacteria,42SNF@68525|delta/epsilon subdivisions,2X6IF@28221|Deltaproteobacteria,2Z22A@29|Myxococcales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD1_k127_1156630_12	929713.NIASO_13260	1.062e-06	55.0	2EBPV@1|root,335PY@2|Bacteria,4P5WA@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1360)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1360
HKD1_k127_1156630_8	639030.JHVA01000001_gene572	4.435e-35	142.0	COG5478@1|root,COG5478@2|Bacteria,3Y7XG@57723|Acidobacteria,2JN0C@204432|Acidobacteriia	204432|Acidobacteriia	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD1_k127_1156630_6	661478.OP10G_2755	2.668e-54	195.0	COG0221@1|root,COG0221@2|Bacteria	2|Bacteria	C	inorganic diphosphatase activity	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD1_k127_1156630_3	382464.ABSI01000010_gene3441	1.941e-63	225.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia,2IUBG@203494|Verrucomicrobiae	74201|Verrucomicrobia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_1156630_7	1396141.BATP01000039_gene1348	3.365e-39	161.0	COG4585@1|root,COG4585@2|Bacteria,46V1V@74201|Verrucomicrobia,2IVY4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD1_k127_1168544_19	59196.RICGR_1385	6.016e-19	86.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1JCDH@118969|Legionellales	118969|Legionellales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_1168544_11	497964.CfE428DRAFT_4163	3.771e-73	252.0	COG0452@1|root,COG0452@2|Bacteria,46SPU@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Flavoprotein	-	-	4.1.1.36	ko:K01598	ko00770,ko01100,map00770,map01100	M00120	R03269	RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_1168544_12	1156937.MFUM_700135	1.437e-70	247.0	COG0194@1|root,COG0194@2|Bacteria,46SQG@74201|Verrucomicrobia,37GTD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Guanylate kinase	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD1_k127_1168544_4	497964.CfE428DRAFT_4161	1.989e-117	384.0	COG1561@1|root,COG1561@2|Bacteria,46TP9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF1732)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_1168544_8	404589.Anae109_2127	9.412e-100	339.0	COG1055@1|root,COG1055@2|Bacteria,1NEVR@1224|Proteobacteria,42NU5@68525|delta/epsilon subdivisions,2WJV4@28221|Deltaproteobacteria,2YX9Q@29|Myxococcales	28221|Deltaproteobacteria	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD1_k127_1168544_9	497964.CfE428DRAFT_4767	5.205e-96	330.0	COG1194@1|root,COG1194@2|Bacteria,46SR4@74201|Verrucomicrobia	74201|Verrucomicrobia	L	endonuclease III	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,NUDIX_4
HKD1_k127_1168544_5	497964.CfE428DRAFT_4766	2.459e-113	374.0	COG1039@1|root,COG1039@2|Bacteria,46UTB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	-	-	3.1.26.4	ko:K03471	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_1168544_16	497964.CfE428DRAFT_4765	3.095e-39	150.0	COG0776@1|root,COG0776@2|Bacteria,46T4V@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Belongs to the bacterial histone-like protein family	-	-	-	ko:K03530,ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_1168544_7	886293.Sinac_6389	8.008e-100	355.0	COG0745@1|root,COG2202@1|root,COG5002@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_1168544_0	497964.CfE428DRAFT_2520	2.742e-216	683.0	COG1215@1|root,COG1215@2|Bacteria,46SF7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_2_3
HKD1_k127_1168544_13	497964.CfE428DRAFT_2522	2.144e-52	194.0	COG1376@1|root,COG1376@2|Bacteria,46VQZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_1168544_21	91464.S7335_1834	2.722e-06	53.0	COG0268@1|root,COG0268@2|Bacteria,1G7PV@1117|Cyanobacteria,1H0RF@1129|Synechococcus	1117|Cyanobacteria	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD1_k127_1168544_14	497964.CfE428DRAFT_2131	1.758e-41	161.0	29NX7@1|root,309VB@2|Bacteria,46WPG@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1168544_6	671143.DAMO_1598	3.084e-105	350.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_1168544_3	886293.Sinac_6549	7.28e-122	399.0	COG0022@1|root,COG0022@2|Bacteria,2IYRX@203682|Planctomycetes	203682|Planctomycetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_1168544_18	1396141.BATP01000031_gene4774	5.388e-21	96.0	COG0508@1|root,COG0508@2|Bacteria,46SHZ@74201|Verrucomicrobia,2IU2H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	e3 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_1168544_10	497964.CfE428DRAFT_0130	1.603e-92	315.0	COG0508@1|root,COG0508@2|Bacteria,46SHZ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_1168544_20	309803.CTN_0697	2.168e-11	71.0	COG3339@1|root,COG3339@2|Bacteria,2GEFC@200918|Thermotogae	200918|Thermotogae	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD1_k127_1168544_2	395961.Cyan7425_2963	2.164e-123	404.0	COG0500@1|root,COG2226@2|Bacteria,1FZVZ@1117|Cyanobacteria	1117|Cyanobacteria	Q	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_1168544_1	497964.CfE428DRAFT_5373	3.801e-146	473.0	COG0232@1|root,COG0232@2|Bacteria,46UHP@74201|Verrucomicrobia	74201|Verrucomicrobia	F	SMART metal-dependent phosphohydrolase HD region	-	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD1_k127_1168544_17	497964.CfE428DRAFT_5372	3.25e-37	150.0	COG0466@1|root,COG0466@2|Bacteria,46WE2@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S16 lon domain protein	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD1_k127_1168544_15	497964.CfE428DRAFT_4615	2.446e-39	154.0	COG0710@1|root,COG0710@2|Bacteria,46VMG@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Type I 3-dehydroquinase	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
HKD1_k127_1198903_6	497964.CfE428DRAFT_2386	3.621e-13	69.0	COG2084@1|root,COG2084@2|Bacteria,46S95@74201|Verrucomicrobia	74201|Verrucomicrobia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_1198903_3	497964.CfE428DRAFT_0215	4.741e-64	230.0	COG1716@1|root,COG2114@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria	2|Bacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	cya1	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,Guanylate_cyc
HKD1_k127_1198903_1	1403819.BATR01000051_gene1473	3.853e-92	336.0	COG0515@1|root,COG0515@2|Bacteria,46UMT@74201|Verrucomicrobia,2IVH7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PEGA,PG_binding_1,Pkinase
HKD1_k127_1198903_0	1122604.JONR01000031_gene1279	2.168e-114	403.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_1198903_2	1382306.JNIM01000001_gene623	1.522e-78	278.0	COG2124@1|root,COG2124@2|Bacteria,2G7SX@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_1198903_5	1286093.C266_07457	1.108e-22	103.0	COG2146@1|root,COG2146@2|Bacteria,1N72F@1224|Proteobacteria,2VTX8@28216|Betaproteobacteria,1K7S5@119060|Burkholderiaceae	28216|Betaproteobacteria	P	rieske 2fe-2s	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD1_k127_1198903_7	1156935.QWE_13573	1.38e-12	74.0	COG2373@1|root,COG2373@2|Bacteria,1QXEG@1224|Proteobacteria,2TX94@28211|Alphaproteobacteria,4BNYF@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Animal haem peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase
HKD1_k127_1198903_4	497964.CfE428DRAFT_2403	1.471e-32	133.0	COG5512@1|root,COG5512@2|Bacteria,46WKB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD1_k127_1198903_8	1183377.Py04_1134	5.706e-12	67.0	COG0493@1|root,arCOG01292@2157|Archaea,2XVPT@28890|Euryarchaeota,243XT@183968|Thermococci	183968|Thermococci	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.8.1.19	ko:K20202	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_1204864_3	497964.CfE428DRAFT_4454	2.489e-13	71.0	COG1088@1|root,COG1088@2|Bacteria,46S98@74201|Verrucomicrobia	2|Bacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	rfbB	GO:0000166,GO:0000271,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005975,GO:0005976,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008460,GO:0009058,GO:0009059,GO:0009225,GO:0009226,GO:0009987,GO:0016051,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019305,GO:0019438,GO:0030312,GO:0033692,GO:0034637,GO:0034641,GO:0034645,GO:0034654,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0044271,GO:0044281,GO:0044464,GO:0045226,GO:0046379,GO:0046383,GO:0046483,GO:0048037,GO:0050662,GO:0051287,GO:0055086,GO:0070404,GO:0071704,GO:0071944,GO:0097159,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	4.2.1.46,4.2.1.76	ko:K01710,ko:K12450	ko00520,ko00521,ko00523,ko00525,ko01055,ko01130,map00520,map00521,map00523,map00525,map01055,map01130	M00793	R00293,R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	iNJ661.Rv3464	GDP_Man_Dehyd
HKD1_k127_1204864_1	497964.CfE428DRAFT_4456	3.465e-129	432.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_1204864_0	497964.CfE428DRAFT_4457	7.616e-133	449.0	COG5427@1|root,COG5427@2|Bacteria	2|Bacteria	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1204864_4	309799.DICTH_0765	3.477e-05	54.0	COG0613@1|root,COG0613@2|Bacteria	2|Bacteria	Q	PHP domain protein	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	AAA_21,AAA_23,AlbA_2,PHP,PHP_C
HKD1_k127_1204864_2	316274.Haur_4505	5.886e-27	117.0	COG5624@1|root,COG5624@2|Bacteria,2G94N@200795|Chloroflexi,377N8@32061|Chloroflexia	200795|Chloroflexi	K	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1216074_6	497964.CfE428DRAFT_1614	1.994e-07	54.0	COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_1216074_4	497964.CfE428DRAFT_2349	9.856e-75	265.0	COG0760@1|root,COG0760@2|Bacteria,46SU4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD1_k127_1216074_1	497964.CfE428DRAFT_2348	1.956e-117	385.0	COG1995@1|root,COG1995@2|Bacteria,46SNQ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_1216074_3	497964.CfE428DRAFT_2347	1.789e-98	328.0	COG4587@1|root,COG4587@2|Bacteria,46VAG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HKD1_k127_1216074_0	760568.Desku_3111	1.518e-120	405.0	COG0045@1|root,COG0045@2|Bacteria,1TQG4@1239|Firmicutes,249ED@186801|Clostridia,2609X@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the succinate malate CoA ligase beta subunit family	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
HKD1_k127_1216074_2	760568.Desku_3109	3.29e-108	366.0	COG0074@1|root,COG0074@2|Bacteria,1TPIT@1239|Firmicutes,249MP@186801|Clostridia,266YX@186807|Peptococcaceae	186801|Clostridia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Succ_CoA_lig
HKD1_k127_1216074_5	1047013.AQSP01000140_gene2448	6.909e-37	156.0	COG0372@1|root,COG0372@2|Bacteria	2|Bacteria	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1,4.1.3.34	ko:K01647,ko:K15234	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R00351,R00354	RC00004,RC00067,RC00502	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_1256733_9	240016.ABIZ01000001_gene5812	6.309e-128	411.0	COG0426@1|root,COG0426@2|Bacteria,46UCH@74201|Verrucomicrobia,2IV55@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_12	1298858.AUEL01000019_gene3259	8.636e-79	269.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VFHH@28211|Alphaproteobacteria,43RJV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	ko:K07684	ko02020,map02020	M00471	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD1_k127_1256733_11	748247.AZKH_2519	3.801e-92	333.0	COG2203@1|root,COG4585@1|root,COG2203@2|Bacteria,COG4585@2|Bacteria,1R43J@1224|Proteobacteria,2VPEB@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02486	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	CHASE5,HAMP,HATPase_c,HisKA_3,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_1256733_32	1356854.N007_14960	5.193e-20	106.0	COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1TRH0@1239|Firmicutes,4HD4A@91061|Bacilli,2799P@186823|Alicyclobacillaceae	91061|Bacilli	T	PAS fold	-	-	2.7.13.3	ko:K02491	ko02020,map02020	M00485	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	5TM-5TMR_LYT,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_1256733_35	497964.CfE428DRAFT_0798	2.553e-18	92.0	COG5637@1|root,COG5637@2|Bacteria,46W7X@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc
HKD1_k127_1256733_24	382464.ABSI01000011_gene2994	3.299e-48	177.0	2DQ7E@1|root,3353C@2|Bacteria,46SU5@74201|Verrucomicrobia,2IUQR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD1_k127_1256733_23	323097.Nham_2694	2.531e-49	180.0	COG1073@1|root,COG1765@1|root,COG1073@2|Bacteria,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,3JQSS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	OsmC-like protein	MA20_16590	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
HKD1_k127_1256733_28	682795.AciX8_4415	2.458e-30	123.0	2DMEF@1|root,32QYK@2|Bacteria,3Y516@57723|Acidobacteria,2JJEQ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_5	497964.CfE428DRAFT_2921	1.655e-155	501.0	COG0438@1|root,COG0438@2|Bacteria,46VPZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_18	497964.CfE428DRAFT_2920	3.154e-70	243.0	COG0110@1|root,COG0110@2|Bacteria,46T6H@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_1256733_3	497964.CfE428DRAFT_2919	1.15e-214	683.0	COG1132@1|root,COG1132@2|Bacteria,46SH3@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_membrane,ABC_tran
HKD1_k127_1256733_17	497964.CfE428DRAFT_5674	2.231e-70	244.0	COG0586@1|root,COG0586@2|Bacteria,46SWW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SNARE associated Golgi protein	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD1_k127_1256733_4	497964.CfE428DRAFT_2917	1.632e-200	632.0	COG0015@1|root,COG0015@2|Bacteria,46UUE@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Adenylosuccinate lyase C-terminus	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD1_k127_1256733_6	1184267.A11Q_1776	5.309e-154	498.0	COG1252@1|root,COG1252@2|Bacteria,1MX96@1224|Proteobacteria,42PFG@68525|delta/epsilon subdivisions,2MSNE@213481|Bdellovibrionales,2WKPM@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_1256733_37	1396418.BATQ01000142_gene3284	9.06e-14	76.0	COG0291@1|root,COG0291@2|Bacteria,46TCI@74201|Verrucomicrobia,2IUW5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal protein L35	-	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD1_k127_1256733_36	1403819.BATR01000016_gene485	6.106e-17	84.0	2CK93@1|root,2ZJ73@2|Bacteria,46WK8@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_26	1123242.JH636435_gene1339	1.076e-40	155.0	COG0537@1|root,COG0537@2|Bacteria,2J045@203682|Planctomycetes	203682|Planctomycetes	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_1256733_25	1396418.BATQ01000106_gene5316	3.99e-46	172.0	COG1327@1|root,COG1327@2|Bacteria,46TAA@74201|Verrucomicrobia,2IU77@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_1256733_30	1157490.EL26_07285	6.336e-27	123.0	COG0697@1|root,COG0697@2|Bacteria,1TSE2@1239|Firmicutes,4HBD2@91061|Bacilli,279DE@186823|Alicyclobacillaceae	91061|Bacilli	EG	EamA-like transporter family	yoaV3	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_1256733_15	455632.SGR_3841	4.921e-74	265.0	COG1520@1|root,COG1520@2|Bacteria,2GW3X@201174|Actinobacteria	201174|Actinobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HKD1_k127_1256733_0	76114.ebA2963	7.442e-288	912.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2VHUF@28216|Betaproteobacteria,2KUMN@206389|Rhodocyclales	206389|Rhodocyclales	L	DNA topoisomerase III	-	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
HKD1_k127_1256733_7	497964.CfE428DRAFT_5447	1.007e-144	467.0	COG0758@1|root,COG0758@2|Bacteria,46SGR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM DNA protecting protein DprA	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A,HHH_5
HKD1_k127_1256733_20	497964.CfE428DRAFT_1541	2.06e-54	194.0	COG0629@1|root,COG0629@2|Bacteria,46VGA@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD1_k127_1256733_29	497964.CfE428DRAFT_1542	6.68e-30	121.0	COG0360@1|root,COG0360@2|Bacteria	2|Bacteria	J	Binds together with S18 to 16S ribosomal RNA	rpsF	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0019843,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070181,GO:0097159,GO:1901363,GO:1990904	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD1_k127_1256733_22	484770.UFO1_4295	1.178e-50	186.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,4H4AW@909932|Negativicutes	909932|Negativicutes	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD1_k127_1256733_19	497964.CfE428DRAFT_1544	5.577e-62	223.0	COG1825@1|root,COG1825@2|Bacteria,46SZS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD1_k127_1256733_10	1156937.MFUM_870060	1.178e-127	417.0	COG0462@1|root,COG0462@2|Bacteria,46SVH@74201|Verrucomicrobia,37GGN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD1_k127_1256733_8	497964.CfE428DRAFT_1380	7.217e-134	435.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD1_k127_1256733_33	497964.CfE428DRAFT_4444	1.167e-19	92.0	28X6Y@1|root,2ZJ59@2|Bacteria,46WIZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_16	497964.CfE428DRAFT_4443	7.872e-71	247.0	COG0561@1|root,COG0561@2|Bacteria,46SWT@74201|Verrucomicrobia	74201|Verrucomicrobia	S	haloacid dehalogenase-like hydrolase	cof	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD1_k127_1256733_14	497964.CfE428DRAFT_0897	4.034e-76	261.0	2BXAM@1|root,2ZPRA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_13	497964.CfE428DRAFT_0896	4.513e-77	263.0	COG1595@1|root,COG1595@2|Bacteria,46V3R@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_1256733_31	497964.CfE428DRAFT_0894	1.014e-21	100.0	295MM@1|root,2ZSZ1@2|Bacteria,46WK9@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1256733_2	251221.35211291	3.964e-272	864.0	COG0308@1|root,COG0308@2|Bacteria,1G03V@1117|Cyanobacteria	1117|Cyanobacteria	CE	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD1_k127_1256733_21	497964.CfE428DRAFT_1441	2.262e-53	193.0	COG0454@1|root,COG0456@2|Bacteria,46T1U@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_1256733_34	497964.CfE428DRAFT_1422	1.204e-19	90.0	COG0230@1|root,COG0230@2|Bacteria,46WMF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein L34	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD1_k127_1256733_40	497964.CfE428DRAFT_0066	1.301e-06	50.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,46TTW@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Pkinase
HKD1_k127_1256733_41	497964.CfE428DRAFT_0066	2.832e-06	49.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,46TTW@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Pkinase
HKD1_k127_1256733_1	452637.Oter_1899	1.353e-283	894.0	COG0577@1|root,COG0577@2|Bacteria,46TJI@74201|Verrucomicrobia	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_1320957_5	497964.CfE428DRAFT_4379	3.705e-33	131.0	COG1664@1|root,COG1664@2|Bacteria,46VS6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_1320957_0	1396418.BATQ01000183_gene992	1.384e-296	922.0	COG1154@1|root,COG1154@2|Bacteria,46SAU@74201|Verrucomicrobia,2ITIS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_1320957_6	497964.CfE428DRAFT_3285	2.762e-21	96.0	COG1722@1|root,COG1722@2|Bacteria,46TB2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD1_k127_1320957_9	525904.Tter_1914	2.587e-16	88.0	COG4122@1|root,COG4122@2|Bacteria	2|Bacteria	E	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD1_k127_1320957_4	1396141.BATP01000007_gene5666	5.868e-42	157.0	COG0509@1|root,COG0509@2|Bacteria,46VKU@74201|Verrucomicrobia,2IUJ1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD1_k127_1320957_1	497964.CfE428DRAFT_2626	3.063e-127	423.0	COG0404@1|root,COG0404@2|Bacteria,46UPA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glycine cleavage T-protein C-terminal barrel domain	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD1_k127_1320957_3	497964.CfE428DRAFT_2627	1.574e-88	299.0	COG0705@1|root,COG0705@2|Bacteria,46SY5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1320957_2	1396141.BATP01000060_gene4688	4.356e-103	342.0	COG3253@1|root,COG3253@2|Bacteria,46SQD@74201|Verrucomicrobia,2IVHP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD1_k127_1320957_10	1227500.C494_04346	1.415e-10	69.0	arCOG08193@1|root,arCOG08193@2157|Archaea,2XVQ3@28890|Euryarchaeota,23U2C@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1320957_8	63737.Npun_R3135	2.187e-17	93.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_1320957_7	1123392.AQWL01000003_gene262	2.9e-21	99.0	COG1073@1|root,COG2885@1|root,COG1073@2|Bacteria,COG2885@2|Bacteria,1RFNW@1224|Proteobacteria,2W31D@28216|Betaproteobacteria	28216|Betaproteobacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1343469_3	497964.CfE428DRAFT_4114	1.681e-111	365.0	COG1043@1|root,COG1043@2|Bacteria,46SD4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_1343469_0	1396141.BATP01000019_gene1607	2.292e-175	566.0	COG0497@1|root,COG0497@2|Bacteria,46SGB@74201|Verrucomicrobia,2IU0W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	RecF/RecN/SMC N terminal domain	-	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD1_k127_1343469_8	247490.KSU1_D0778	1.377e-46	172.0	COG0614@1|root,COG0614@2|Bacteria,2J06G@203682|Planctomycetes	203682|Planctomycetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_1343469_6	497964.CfE428DRAFT_1264	1.869e-79	271.0	COG1584@1|root,COG1584@2|Bacteria,46T3N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM GPR1 FUN34 yaaH family protein	-	-	-	ko:K07034	-	-	-	-	ko00000	-	-	-	Grp1_Fun34_YaaH
HKD1_k127_1343469_2	497964.CfE428DRAFT_6235	1.136e-138	451.0	COG0446@1|root,COG0446@2|Bacteria,46SG9@74201|Verrucomicrobia	2|Bacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.7.1.15	ko:K00362,ko:K07001	ko00910,ko01120,map00910,map01120	M00530	R00787	RC00176	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF3734,Patatin,Pyr_redox_2,Reductase_C
HKD1_k127_1343469_10	497964.CfE428DRAFT_5650	1.336e-21	100.0	2EGRU@1|root,33AI0@2|Bacteria,46WFI@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1343469_4	118173.KB235914_gene2445	4.874e-91	306.0	COG4870@1|root,COG4870@2|Bacteria,1G85R@1117|Cyanobacteria,1H9NA@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM Papain family cysteine protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
HKD1_k127_1343469_7	533240.CRC_03116	1.563e-64	230.0	COG0500@1|root,COG0500@2|Bacteria,1G8N3@1117|Cyanobacteria	1117|Cyanobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_1343469_11	1280692.AUJL01000019_gene936	0.0003797	46.0	2BE7V@1|root,327YV@2|Bacteria,1UTVX@1239|Firmicutes,254K5@186801|Clostridia,36TRY@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1343469_9	1184267.A11Q_1123	6.196e-43	166.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2MT9J@213481|Bdellovibrionales,2WQ6E@28221|Deltaproteobacteria	213481|Bdellovibrionales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_1343469_5	497964.CfE428DRAFT_1521	4.075e-85	287.0	COG0461@1|root,COG0461@2|Bacteria,46SZV@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_1343469_1	1118054.CAGW01000053_gene1386	2.827e-159	508.0	COG0179@1|root,COG0179@2|Bacteria,1VRIW@1239|Firmicutes,4HUFK@91061|Bacilli,26U89@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HKD1_k127_134799_2	1192034.CAP_4903	1.872e-09	62.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_4
HKD1_k127_134799_1	234267.Acid_0813	7.296e-149	479.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria	57723|Acidobacteria	E	aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_134799_0	234267.Acid_0814	4.476e-173	556.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1350150_3	661478.OP10G_3225	3.18e-174	554.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	adh	-	1.1.1.14	ko:K00008	ko00040,ko00051,ko01100,map00040,map00051,map01100	M00014	R00875,R01896	RC00085,RC00102	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1350150_12	1462526.BN990_03638	2.496e-10	72.0	COG0791@1|root,COG3409@1|root,COG0791@2|Bacteria,COG3409@2|Bacteria,1UW8N@1239|Firmicutes,4I2DP@91061|Bacilli,4C6RV@84406|Virgibacillus	91061|Bacilli	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60,PG_binding_1
HKD1_k127_1350150_0	478741.JAFS01000002_gene551	0.0	1190.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,46SVA@74201|Verrucomicrobia,37FY0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_1350150_7	247490.KSU1_B0440	1.634e-39	151.0	2AVTU@1|root,31MME@2|Bacteria,2J2ZG@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1350150_8	382464.ABSI01000012_gene2111	2.372e-39	151.0	COG2010@1|root,COG2010@2|Bacteria,46W25@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HKD1_k127_1350150_5	330214.NIDE4060	2.402e-107	359.0	COG1858@1|root,COG1858@2|Bacteria,3J0GH@40117|Nitrospirae	40117|Nitrospirae	C	Di-haem cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD1_k127_1350150_9	240016.ABIZ01000001_gene2278	4.364e-39	157.0	COG0589@1|root,COG0589@2|Bacteria,46WCC@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1350150_10	309807.SRU_1985	1.235e-18	94.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1350150_1	926566.Terro_1107	9.14e-264	842.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria,2JIQJ@204432|Acidobacteriia	204432|Acidobacteriia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_1350150_4	748247.AZKH_1669	8.461e-110	359.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria	28216|Betaproteobacteria	V	abc transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1350150_2	195250.CM001776_gene1527	2.556e-235	752.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1GZYN@1129|Synechococcus	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_1350150_6	1123368.AUIS01000028_gene1325	9.052e-102	344.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
HKD1_k127_1350150_11	497964.CfE428DRAFT_3261	1.154e-10	64.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,46S9M@74201|Verrucomicrobia	74201|Verrucomicrobia	CJ	CoA binding domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_1360977_0	204669.Acid345_1151	2.432e-283	886.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD1_k127_1360977_2	1163617.SCD_n00020	1.898e-98	342.0	COG0668@1|root,COG0668@2|Bacteria,1MW7V@1224|Proteobacteria,2VHE7@28216|Betaproteobacteria	28216|Betaproteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_1360977_1	1267534.KB906756_gene3	5.003e-189	597.0	COG1680@1|root,COG1680@2|Bacteria	2|Bacteria	V	peptidase activity	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Beta-lactamase
HKD1_k127_1407082_1	497964.CfE428DRAFT_3497	2.341e-276	864.0	COG0465@1|root,COG0465@2|Bacteria,46SB7@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD1_k127_1407082_17	497964.CfE428DRAFT_3037	4.43e-108	364.0	COG3178@1|root,COG3178@2|Bacteria,46SU7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Phosphotransferase enzyme family	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD1_k127_1407082_22	478741.JAFS01000001_gene1471	6.143e-67	240.0	COG1208@1|root,COG1208@2|Bacteria,46SJP@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_1407082_42	391008.Smal_3810	1.294e-10	74.0	COG0793@1|root,COG0793@2|Bacteria,1N4T9@1224|Proteobacteria,1SE36@1236|Gammaproteobacteria,1X70X@135614|Xanthomonadales	135614|Xanthomonadales	M	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2
HKD1_k127_1407082_5	234267.Acid_1245	3.485e-186	595.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1407082_6	886293.Sinac_4878	5.652e-168	546.0	COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1407082_45	497964.CfE428DRAFT_4931	1.274e-07	62.0	COG3330@1|root,COG3330@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4912)	-	-	-	ko:K09942	-	-	-	-	ko00000	-	-	-	DUF4912,Rho_N
HKD1_k127_1407082_30	497964.CfE428DRAFT_0201	9.925e-47	173.0	COG0615@1|root,COG0615@2|Bacteria,46SUW@74201|Verrucomicrobia	74201|Verrucomicrobia	IM	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like,Formyl_trans_N
HKD1_k127_1407082_21	497964.CfE428DRAFT_0202	3.504e-72	248.0	COG0299@1|root,COG0299@2|Bacteria,46SS6@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD1_k127_1407082_15	497964.CfE428DRAFT_3158	5.802e-109	366.0	COG0240@1|root,COG0240@2|Bacteria,46SQJ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD1_k127_1407082_31	240016.ABIZ01000001_gene1711	1.002e-46	175.0	COG0344@1|root,COG0344@2|Bacteria,46VTA@74201|Verrucomicrobia,2IUDC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Glycerol-3-phosphate acyltransferase	-	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD1_k127_1407082_2	497964.CfE428DRAFT_6356	3.59e-255	801.0	COG0445@1|root,COG0445@2|Bacteria,46SID@74201|Verrucomicrobia	74201|Verrucomicrobia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD1_k127_1407082_24	497964.CfE428DRAFT_6271	6.318e-64	227.0	COG0398@1|root,COG0398@2|Bacteria,46WAK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_1407082_10	338963.Pcar_1732	3.352e-136	439.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,42P5X@68525|delta/epsilon subdivisions,2WIQW@28221|Deltaproteobacteria,43V2E@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD1_k127_1407082_40	65093.PCC7418_3764	4.287e-24	107.0	COG1278@1|root,COG1278@2|Bacteria,1G5DM@1117|Cyanobacteria	1117|Cyanobacteria	K	'Cold-shock' DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD1_k127_1407082_0	479434.Sthe_2691	1.258e-306	955.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_1407082_28	316067.Geob_2819	2.709e-50	184.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,42TV7@68525|delta/epsilon subdivisions,2WRW0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_1407082_35	497964.CfE428DRAFT_4835	4.329e-33	134.0	COG4747@1|root,COG4747@2|Bacteria,46WIS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD1_k127_1407082_8	670307.HYPDE_29508	1.68e-149	485.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2VDGB@28211|Alphaproteobacteria,3N7P3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1407082_19	196490.AUEZ01000066_gene2443	5.666e-86	307.0	28J0S@1|root,2Z8XX@2|Bacteria,1P9IP@1224|Proteobacteria,2TSZQ@28211|Alphaproteobacteria,3JVZV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1407082_27	497964.CfE428DRAFT_5732	1.671e-51	198.0	COG0810@1|root,COG1388@1|root,COG0810@2|Bacteria,COG1388@2|Bacteria,46T61@74201|Verrucomicrobia	74201|Verrucomicrobia	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_2,LysM
HKD1_k127_1407082_39	1123230.ARQJ01000010_gene909	3.597e-25	116.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,4H9MJ@91061|Bacilli,4GX76@90964|Staphylococcaceae	91061|Bacilli	S	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_1407082_20	497964.CfE428DRAFT_6628	1.81e-79	278.0	COG0707@1|root,COG0707@2|Bacteria,46SK7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Monogalactosyldiacylglycerol (MGDG) synthase	-	-	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glyco_trans_1_4,MGDG_synth
HKD1_k127_1407082_13	497964.CfE428DRAFT_2574	5.843e-122	402.0	COG1820@1|root,COG1820@2|Bacteria	2|Bacteria	G	Belongs to the metallo-dependent hydrolases superfamily. NagA family	nagA	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1407082_9	1396141.BATP01000007_gene5592	2.459e-139	462.0	COG0644@1|root,COG0644@2|Bacteria,46TJ0@74201|Verrucomicrobia,2IV4G@203494|Verrucomicrobiae	2|Bacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Trp_halogenase
HKD1_k127_1407082_36	497964.CfE428DRAFT_5396	2.975e-32	131.0	2DQE3@1|root,3368V@2|Bacteria,46WIA@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1407082_12	497964.CfE428DRAFT_2138	1.301e-125	412.0	COG1989@1|root,COG1989@2|Bacteria,46TWT@74201|Verrucomicrobia	74201|Verrucomicrobia	NOU	Type IV leader peptidase family	-	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD1_k127_1407082_25	497964.CfE428DRAFT_5780	1.404e-59	215.0	COG0805@1|root,COG0805@2|Bacteria,46T26@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_1407082_26	497964.CfE428DRAFT_4717	1.761e-57	207.0	COG0494@1|root,COG0494@2|Bacteria	2|Bacteria	L	nUDIX hydrolase	nudF_1	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_1407082_43	1122201.AUAZ01000003_gene1901	1.41e-10	66.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,467QU@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folB	GO:0003674,GO:0003824,GO:0004150,GO:0005488,GO:0005515,GO:0016829,GO:0016830,GO:0016832,GO:0042802	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	iECDH1ME8569_1439.ECDH1ME8569_2955,iECSE_1348.ECSE_3338,iPC815.YPO0648,iSBO_1134.SBO_2914,iSDY_1059.SDY_3241,iSFxv_1172.SFxv_3403,iUTI89_1310.UTI89_C3494,iYL1228.KPN_03462,ic_1306.c3808	FolB
HKD1_k127_1407082_3	497964.CfE428DRAFT_2944	1.281e-242	765.0	COG1132@1|root,COG1132@2|Bacteria,46TV7@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1407082_33	497964.CfE428DRAFT_3470	8.463e-43	162.0	2C7E5@1|root,34B8M@2|Bacteria,46W92@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1407082_38	497964.CfE428DRAFT_3468	1.401e-25	107.0	2ERDX@1|root,33IZH@2|Bacteria,46WUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	May function as a protein modifier covalently attached to lysine residues of substrate proteins. This may serve to target the modified proteins for degradation by proteasomes	ubact	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1407082_16	497964.CfE428DRAFT_3467	3.478e-108	359.0	COG0638@1|root,COG0638@2|Bacteria,46UC7@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasome subunit	-	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD1_k127_1407082_18	497964.CfE428DRAFT_3466	1.15e-90	308.0	COG0638@1|root,COG0638@2|Bacteria,46VYB@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasome subunit	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD1_k127_1407082_29	497964.CfE428DRAFT_3465	4.835e-47	179.0	COG0860@1|root,COG0860@2|Bacteria,46VNJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD1_k127_1407082_37	497964.CfE428DRAFT_3464	8.415e-28	122.0	COG4249@1|root,COG4249@2|Bacteria,46WW5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_1407082_23	497964.CfE428DRAFT_3463	1.69e-64	230.0	29XKE@1|root,30JBI@2|Bacteria,46WEB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_1407082_32	497964.CfE428DRAFT_4704	1.718e-46	176.0	COG2825@1|root,COG2825@2|Bacteria,46T22@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM outer membrane chaperone Skp (OmpH)	hlpA	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD1_k127_1407082_4	497964.CfE428DRAFT_4705	9.863e-195	632.0	COG4775@1|root,COG4775@2|Bacteria,46S5F@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_1407082_7	497964.CfE428DRAFT_2621	2.765e-166	535.0	COG1030@1|root,COG1030@2|Bacteria,46TAS@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
HKD1_k127_1407082_34	1191523.MROS_0856	1.647e-34	138.0	COG2606@1|root,COG2606@2|Bacteria	2|Bacteria	S	Cys-tRNA(Pro) hydrolase activity	-	-	-	ko:K03976,ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_1407082_11	637389.Acaty_c0368	2.437e-127	422.0	COG0477@1|root,COG0477@2|Bacteria,1NS3F@1224|Proteobacteria,1RQRF@1236|Gammaproteobacteria,2NBX2@225057|Acidithiobacillales	225057|Acidithiobacillales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD1_k127_1407082_14	234267.Acid_4868	2.382e-117	389.0	COG2326@1|root,COG2326@2|Bacteria,3Y5E4@57723|Acidobacteria	57723|Acidobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD1_k127_1439320_0	497964.CfE428DRAFT_0324	0.0	1334.0	COG0178@1|root,COG0178@2|Bacteria,46SEB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_1439320_2	497964.CfE428DRAFT_0325	1.038e-113	397.0	COG1729@1|root,COG1729@2|Bacteria,46T9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_1439320_1	497964.CfE428DRAFT_6592	1.318e-234	736.0	COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_1439515_19	671143.DAMO_0361	1.944e-39	151.0	COG1764@1|root,COG1764@2|Bacteria	2|Bacteria	O	response to oxidative stress	ymaD	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_1439515_3	452637.Oter_0818	1.197e-214	673.0	COG0334@1|root,COG0334@2|Bacteria,46UBX@74201|Verrucomicrobia,3K7SK@414999|Opitutae	414999|Opitutae	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.4	ko:K00262	ko00220,ko00250,ko00910,ko01100,map00220,map00250,map00910,map01100	-	R00248	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_1439515_25	1408419.JHYG01000001_gene1721	0.0002075	48.0	2EQUD@1|root,33IE5@2|Bacteria,1NN93@1224|Proteobacteria	2|Bacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD1_k127_1439515_10	439235.Dalk_2978	1.013e-109	359.0	COG1216@1|root,COG1216@2|Bacteria,1R50T@1224|Proteobacteria,42P74@68525|delta/epsilon subdivisions,2WK88@28221|Deltaproteobacteria,2MJIE@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,Methyltransf_23
HKD1_k127_1439515_12	452637.Oter_0860	9.599e-91	307.0	COG0123@1|root,COG0123@2|Bacteria,46SMT@74201|Verrucomicrobia	74201|Verrucomicrobia	BQ	Histone deacetylase domain	acuC	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD1_k127_1439515_21	591159.ACEZ01000158_gene5593	5.962e-33	134.0	2BARS@1|root,3246W@2|Bacteria,2IM0H@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1439515_24	58344.JOEL01000044_gene886	9.944e-06	49.0	COG2267@1|root,COG2267@2|Bacteria,2GPA8@201174|Actinobacteria	201174|Actinobacteria	I	hydrolase	-	-	3.1.1.5	ko:K01048	ko00564,map00564	-	-	-	ko00000,ko00001,ko01000	-	-	-	Hydrolase_4
HKD1_k127_1439515_5	497964.CfE428DRAFT_0747	3.075e-169	538.0	COG0012@1|root,COG0012@2|Bacteria,46S8D@74201|Verrucomicrobia	74201|Verrucomicrobia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD1_k127_1439515_16	497964.CfE428DRAFT_3472	3.465e-60	215.0	COG1579@1|root,COG1579@2|Bacteria,46T10@74201|Verrucomicrobia	74201|Verrucomicrobia	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD1_k127_1439515_23	235279.HH_1544	1e-09	63.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,42MAJ@68525|delta/epsilon subdivisions,2YMW0@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	O	Alkyl hydroperoxide reductase	ahpC	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_1439515_0	1234364.AMSF01000048_gene2050	8.186e-283	884.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,1RNC8@1236|Gammaproteobacteria,1X4Q2@135614|Xanthomonadales	135614|Xanthomonadales	S	transporter	oliA	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD1_k127_1439515_7	497964.CfE428DRAFT_2179	3.782e-154	494.0	COG1472@1|root,COG1472@2|Bacteria,46S5G@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD1_k127_1439515_18	497964.CfE428DRAFT_2178	4.205e-43	167.0	COG1057@1|root,COG1057@2|Bacteria,46T27@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_1439515_20	1403819.BATR01000107_gene3658	4.468e-34	137.0	COG0799@1|root,COG0799@2|Bacteria,46T8H@74201|Verrucomicrobia,2IUTW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD1_k127_1439515_14	909663.KI867150_gene711	1.168e-72	252.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,43A29@68525|delta/epsilon subdivisions,2X21K@28221|Deltaproteobacteria,2MS4J@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	-	-	-	-	-	-	-	-	-	-	FKBP_C
HKD1_k127_1439515_13	497964.CfE428DRAFT_6234	4.796e-85	291.0	28NXH@1|root,2ZBV3@2|Bacteria,46TF0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1439515_15	497964.CfE428DRAFT_2171	3.29e-64	226.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_1439515_8	497964.CfE428DRAFT_2172	5.095e-131	430.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,46SRG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Competence-damaged protein	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_1439515_2	497964.CfE428DRAFT_2713	3.773e-226	706.0	COG1219@1|root,COG1219@2|Bacteria,46SIK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD1_k127_1439515_11	497964.CfE428DRAFT_2712	2.901e-99	329.0	COG0740@1|root,COG0740@2|Bacteria,46SAB@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_1439515_9	497964.CfE428DRAFT_2711	7.363e-114	381.0	COG0544@1|root,COG0544@2|Bacteria,46SJZ@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_1439515_6	1382359.JIAL01000001_gene2085	2.245e-157	506.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria,2JKVY@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1439515_4	1122176.KB903542_gene336	3.22e-207	658.0	COG3404@1|root,COG3643@1|root,COG3404@2|Bacteria,COG3643@2|Bacteria,4NFE3@976|Bacteroidetes	976|Bacteroidetes	E	Glutamate formimidoyltransferase	ftcD	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_C,FTCD_N
HKD1_k127_1439515_1	204669.Acid345_1048	9.563e-268	833.0	COG2987@1|root,COG2987@2|Bacteria,3Y2VD@57723|Acidobacteria,2JK4Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Urocanase Rossmann-like domain	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD1_k127_1439515_17	240015.ACP_3026	2.847e-56	199.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_1457237_3	1089548.KI783301_gene1256	3.868e-13	70.0	COG3526@1|root,COG3526@2|Bacteria	2|Bacteria	O	Rdx family	-	-	-	ko:K07401	-	-	-	-	ko00000	-	-	-	Rdx
HKD1_k127_1457237_1	1123070.KB899250_gene603	1.782e-88	302.0	COG0709@1|root,COG0709@2|Bacteria	2|Bacteria	E	selenide, water dikinase activity	selD	-	2.7.9.3,2.8.1.7	ko:K01008,ko:K04487	ko00450,ko00730,ko01100,ko04122,map00450,map00730,map01100,map04122	-	R03595,R07460,R11528,R11529	RC00002,RC01789,RC02313,RC02878	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	AIRS,AIRS_C,Pyr_redox_2
HKD1_k127_1457237_0	1123070.KB899248_gene241	9.383e-122	407.0	COG1921@1|root,COG1921@2|Bacteria	2|Bacteria	E	L-seryl-tRNASec selenium transferase activity	selA	GO:0003674,GO:0003824,GO:0004125,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0019752,GO:0019842,GO:0030170,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0090304,GO:0097056,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	iECP_1309.ECP_3693,iSbBS512_1146.SbBS512_E4006	Se-cys_synth_N,SelA
HKD1_k127_1457237_2	1379698.RBG1_1C00001G1762	3.944e-38	154.0	COG3276@1|root,COG3276@2|Bacteria,2NNQU@2323|unclassified Bacteria	2|Bacteria	J	Elongation factor SelB, winged helix	selB	GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD1_k127_1472251_19	935948.KE386495_gene1170	1.307e-14	87.0	COG3055@1|root,COG3055@2|Bacteria,1V8SQ@1239|Firmicutes,25BH8@186801|Clostridia	186801|Clostridia	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
HKD1_k127_1472251_22	756883.Halar_0850	3.833e-09	69.0	COG3794@1|root,arCOG02920@2157|Archaea	2157|Archaea	C	COG3794 Plastocyanin	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD1_k127_1472251_16	1961.JOAK01000027_gene2512	2.238e-18	87.0	2E3SC@1|root,32YPX@2|Bacteria,2GQRK@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_1472251_10	240016.ABIZ01000001_gene654	6.804e-70	247.0	COG0583@1|root,COG0583@2|Bacteria,46V15@74201|Verrucomicrobia,2IUGE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_1472251_0	1403819.BATR01000055_gene1732	1.556e-249	802.0	COG5373@1|root,COG5373@2|Bacteria,46S9T@74201|Verrucomicrobia,2IUWT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HKD1_k127_1472251_11	530564.Psta_0152	4.418e-47	180.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_3,Abhydrolase_6,HIT,Hydrolase_4
HKD1_k127_1472251_18	1123504.JQKD01000006_gene1535	5.853e-15	82.0	29CEM@1|root,2ZZD2@2|Bacteria,1RB3W@1224|Proteobacteria,2VT9S@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1472251_1	1403819.BATR01000057_gene1776	5.112e-113	375.0	COG0673@1|root,COG0673@2|Bacteria,46TQ2@74201|Verrucomicrobia,2IVP0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_1472251_14	497964.CfE428DRAFT_2885	5.813e-28	115.0	COG0227@1|root,COG0227@2|Bacteria,46TBF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD1_k127_1472251_9	497964.CfE428DRAFT_1900	8.238e-71	258.0	2F6YF@1|root,33ZEH@2|Bacteria,46VWD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1472251_13	481448.Minf_0431	5.968e-31	123.0	COG0236@1|root,COG0236@2|Bacteria,46T18@74201|Verrucomicrobia,37GVN@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_1472251_8	1288963.ADIS_4509	2.554e-72	257.0	COG3264@1|root,COG3264@2|Bacteria,4NEAM@976|Bacteroidetes,47PIS@768503|Cytophagia	976|Bacteroidetes	M	Small-conductance mechanosensitive channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_1472251_3	648757.Rvan_0951	3.266e-107	361.0	COG3146@1|root,COG3146@2|Bacteria,1R5A3@1224|Proteobacteria,2U4MR@28211|Alphaproteobacteria,3N8ZM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Peptidogalycan biosysnthesis/recognition	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB_like
HKD1_k127_1472251_5	497964.CfE428DRAFT_1381	5.271e-88	298.0	COG0010@1|root,COG0010@2|Bacteria	2|Bacteria	E	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_1472251_4	1123242.JH636434_gene5244	3.508e-91	324.0	2E55N@1|root,32ZYI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1472251_12	1267535.KB906767_gene3139	9.418e-40	153.0	COG5478@1|root,COG5478@2|Bacteria	2|Bacteria	S	Small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD1_k127_1472251_2	1396141.BATP01000027_gene1075	2.289e-108	382.0	COG4953@1|root,COG4953@2|Bacteria,46TMS@74201|Verrucomicrobia,2IV2J@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD1_k127_1472251_6	497964.CfE428DRAFT_0060	2.238e-84	320.0	COG2373@1|root,COG2373@2|Bacteria,46U44@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Alpha-2-Macroglobulin	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,Thiol-ester_cl
HKD1_k127_1472251_21	118161.KB235922_gene3764	2.171e-09	70.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,3VJ5T@52604|Pleurocapsales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_1472251_7	497964.CfE428DRAFT_0115	2.748e-83	283.0	COG0177@1|root,COG0177@2|Bacteria,46T2G@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_1472251_20	1137281.D778_01482	1.304e-11	76.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1HZNB@117743|Flavobacteriia	976|Bacteroidetes	UW	surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD1_k127_1515324_2	216142.LT40_15905	2.197e-15	76.0	COG5487@1|root,COG5487@2|Bacteria,1NGAH@1224|Proteobacteria,1SGD7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	UPF0391 membrane protein	ytjA	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD1_k127_1515324_0	1163408.UU9_07109	1.321e-107	363.0	COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_1515324_1	1071073.KI530537_gene1595	5.525e-47	183.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,4HAI2@91061|Bacilli,1ZB3A@1386|Bacillus	91061|Bacilli	L	COG1796 DNA polymerase IV (family X)	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD1_k127_1600897_0	247490.KSU1_C1304	2.013e-282	889.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,2IXJN@203682|Planctomycetes	203682|Planctomycetes	G	alpha amylase catalytic	-	-	3.2.1.1,3.2.1.10,5.4.99.16	ko:K01182,ko:K05343	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01557,R01718,R01791,R02108,R02112,R06199,R11262	RC00028,RC00059,RC00077,RC00451,RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3459,Malt_amylase_C
HKD1_k127_1600897_5	1267535.KB906767_gene4015	1.545e-82	280.0	COG5424@1|root,COG5424@2|Bacteria,3Y718@57723|Acidobacteria,2JKMM@204432|Acidobacteriia	204432|Acidobacteriia	H	Iron-containing redox enzyme	-	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2
HKD1_k127_1600897_6	330214.NIDE2979	2.491e-79	284.0	COG0265@1|root,COG0265@2|Bacteria,3J0X9@40117|Nitrospirae	2|Bacteria	M	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	htrA	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD1_k127_1600897_1	497964.CfE428DRAFT_3042	7.124e-244	781.0	COG1200@1|root,COG1200@2|Bacteria,46TTC@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RecG wedge domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_1600897_2	349741.Amuc_0051	2.617e-159	519.0	COG0608@1|root,COG0608@2|Bacteria,46SNV@74201|Verrucomicrobia,2ITRD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DHHA1 domain	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_1600897_8	497964.CfE428DRAFT_1105	4.289e-61	220.0	COG1427@1|root,COG1427@2|Bacteria,46VTU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD1_k127_1600897_3	497964.CfE428DRAFT_1106	3.219e-152	490.0	COG1060@1|root,COG1060@2|Bacteria,46TD4@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD1_k127_1600897_9	497964.CfE428DRAFT_1107	7.208e-60	213.0	COG1595@1|root,COG1595@2|Bacteria,46SZG@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_1600897_11	335543.Sfum_0487	1.896e-19	93.0	COG1950@1|root,COG1950@2|Bacteria,1N1DF@1224|Proteobacteria,42WCF@68525|delta/epsilon subdivisions,2WRES@28221|Deltaproteobacteria,2MQP9@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2
HKD1_k127_1600897_4	497964.CfE428DRAFT_0510	1.932e-100	330.0	COG0522@1|root,COG0522@2|Bacteria,46SNI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD1_k127_1600897_7	497964.CfE428DRAFT_0509	2.131e-63	226.0	COG0100@1|root,COG0100@2|Bacteria,46STW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD1_k127_1600897_10	497964.CfE428DRAFT_0508	2.424e-55	196.0	COG0099@1|root,COG0099@2|Bacteria,46STA@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_1600897_12	1125863.JAFN01000001_gene3318	4.374e-12	66.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,42WXD@68525|delta/epsilon subdivisions,2WSYK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD1_k127_1656899_2	1459636.NTE_01150	1.215e-109	362.0	COG0346@1|root,arCOG03101@2157|Archaea	2157|Archaea	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_1656899_0	497964.CfE428DRAFT_5950	1.211e-264	826.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	emrY	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0033554,GO:0042221,GO:0044425,GO:0044459,GO:0044464,GO:0046677,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0055085,GO:0071944	-	ko:K03446,ko:K07786	ko02020,map02020	M00701	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.3,2.A.1.3.36	-	-	MFS_1
HKD1_k127_1656899_1	497964.CfE428DRAFT_5951	4.375e-177	567.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_1656899_3	886293.Sinac_0962	3.827e-46	172.0	2CYEB@1|root,32T42@2|Bacteria,2J0FP@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_16613_17	221288.JH992901_gene2934	1.677e-63	246.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1JKJ2@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
HKD1_k127_16613_33	1122137.AQXF01000003_gene2307	1.965e-19	104.0	COG4783@1|root,COG4783@2|Bacteria,1QUMJ@1224|Proteobacteria,2TXU6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD1_k127_16613_35	1396418.BATQ01000110_gene4764	1.308e-06	57.0	2BTYD@1|root,32P6T@2|Bacteria,46VNV@74201|Verrucomicrobia,2IW7E@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_16613_14	240015.ACP_2569	1.131e-74	256.0	COG1143@1|root,COG1143@2|Bacteria,3Y6N6@57723|Acidobacteria,2JKQS@204432|Acidobacteriia	204432|Acidobacteriia	C	4Fe-4S dicluster domain	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4_7
HKD1_k127_16613_4	240015.ACP_2568	2.21e-183	580.0	COG0649@1|root,COG0649@2|Bacteria,3Y6MU@57723|Acidobacteria,2JKN7@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_16613_12	1267534.KB906754_gene3779	7.084e-91	303.0	COG0852@1|root,COG0852@2|Bacteria,3Y72R@57723|Acidobacteria,2JM53@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 30 Kd subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD1_k127_16613_11	1267534.KB906754_gene3780	2.256e-95	316.0	COG0377@1|root,COG0377@2|Bacteria,3Y74G@57723|Acidobacteria,2JKT1@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_16613_26	278957.ABEA03000176_gene2798	2.971e-39	149.0	COG0838@1|root,COG0838@2|Bacteria,46XVA@74201|Verrucomicrobia,3K8I9@414999|Opitutae	414999|Opitutae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_16613_25	1123070.KB899251_gene717	3.611e-41	159.0	COG0203@1|root,COG0203@2|Bacteria,46TC9@74201|Verrucomicrobia,2IUE5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD1_k127_16613_8	240016.ABIZ01000001_gene1994	8.164e-152	486.0	COG0202@1|root,COG0202@2|Bacteria,46S52@74201|Verrucomicrobia,2ITN6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD1_k127_16613_28	497964.CfE428DRAFT_4724	3.384e-37	147.0	COG3762@1|root,COG3762@2|Bacteria,46T8V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TPM domain	-	-	-	-	-	-	-	-	-	-	-	-	TPM_phosphatase
HKD1_k127_16613_19	452637.Oter_0011	1.562e-60	222.0	COG1512@1|root,COG1512@2|Bacteria,46T36@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_16613_16	452637.Oter_0012	2.372e-66	232.0	COG1704@1|root,COG1704@2|Bacteria,46V9M@74201|Verrucomicrobia,3K7DK@414999|Opitutae	2|Bacteria	S	PFAM LemA family protein	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_16613_34	1123073.KB899244_gene352	7.473e-11	69.0	COG4319@1|root,COG4319@2|Bacteria,1QDB7@1224|Proteobacteria,1T990@1236|Gammaproteobacteria,1XBUD@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_16613_13	1156937.MFUM_250004	3.215e-89	306.0	COG1680@1|root,COG1680@2|Bacteria,46UDJ@74201|Verrucomicrobia,37GHB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	V	Beta-lactamase	ampC	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_16613_22	240016.ABIZ01000001_gene1756	5.379e-57	206.0	COG1386@1|root,COG1386@2|Bacteria,46VRU@74201|Verrucomicrobia,2IUTS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Segregation and condensation complex subunit ScpB	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpB
HKD1_k127_16613_2	497964.CfE428DRAFT_3032	3.811e-222	698.0	COG1109@1|root,COG1109@2|Bacteria,46SJ2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_16613_3	497964.CfE428DRAFT_3287	7.3e-189	600.0	COG2204@1|root,COG2204@2|Bacteria,46SFE@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_16613_21	497964.CfE428DRAFT_1503	2.937e-58	210.0	COG2867@1|root,COG2867@2|Bacteria	2|Bacteria	I	negative regulation of translational initiation	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2,START
HKD1_k127_16613_1	1183438.GKIL_3722	2.939e-287	899.0	COG1505@1|root,COG1505@2|Bacteria,1G1B7@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase, N-terminal beta-propeller domain	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD1_k127_16613_30	1396141.BATP01000023_gene513	8.555e-28	128.0	2AEXX@1|root,314VS@2|Bacteria,46YXW@74201|Verrucomicrobia,2IUHX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_16613_6	497964.CfE428DRAFT_6711	9.799e-158	507.0	COG5000@1|root,COG5000@2|Bacteria,46S9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	ntrB	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD1_k127_16613_29	93220.LV28_17325	3.8e-31	135.0	COG0628@1|root,COG0628@2|Bacteria,1MW34@1224|Proteobacteria,2VIKI@28216|Betaproteobacteria,1K0I9@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_16613_0	497964.CfE428DRAFT_3556	0.0	1015.0	COG1185@1|root,COG1185@2|Bacteria,46SBP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_16613_31	497964.CfE428DRAFT_3558	7.325e-26	110.0	COG0184@1|root,COG0184@2|Bacteria,46T87@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD1_k127_16613_24	1122185.N792_12190	6.473e-48	180.0	COG1215@1|root,COG1215@2|Bacteria,1QU2M@1224|Proteobacteria,1SCHV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_16613_23	1278073.MYSTI_01900	1.723e-48	178.0	COG1670@1|root,COG1670@2|Bacteria,1N4JG@1224|Proteobacteria	1224|Proteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_16613_20	497964.CfE428DRAFT_5171	9.786e-60	210.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	fosB2	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD1_k127_16613_15	204669.Acid345_4480	2.778e-72	255.0	COG1807@1|root,COG1807@2|Bacteria,3Y383@57723|Acidobacteria,2JIBE@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_16613_18	234267.Acid_5939	7.781e-63	227.0	COG1807@1|root,COG1807@2|Bacteria,3Y383@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_16613_5	452637.Oter_2162	1.421e-158	506.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD1_k127_16613_7	452637.Oter_2161	4.431e-155	496.0	COG4307@1|root,COG4307@2|Bacteria	2|Bacteria	T	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx,zinc-ribbon_6
HKD1_k127_16613_9	1403819.BATR01000162_gene5395	2.327e-145	479.0	COG0457@1|root,COG0457@2|Bacteria,46W9Q@74201|Verrucomicrobia,2IVDS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_16613_32	497964.CfE428DRAFT_1875	6.175e-23	114.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,FGE-sulfatase,Metallophos,NACHT,PEGA,Pkinase
HKD1_k127_16613_10	382464.ABSI01000005_gene1099	8.768e-115	375.0	COG0396@1|root,COG0396@2|Bacteria,46SGE@74201|Verrucomicrobia,2ITY7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD1_k127_16983_0	1123073.KB899241_gene3395	2.032e-199	629.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_16983_1	1125863.JAFN01000001_gene3390	8.013e-130	427.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
HKD1_k127_1729483_3	1278073.MYSTI_00935	7.593e-146	474.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,42YAM@68525|delta/epsilon subdivisions,2WUNV@28221|Deltaproteobacteria,2YV4X@29|Myxococcales	28221|Deltaproteobacteria	F	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD1_k127_1729483_8	1380355.JNIJ01000029_gene3089	3.151e-40	154.0	COG0346@1|root,COG0346@2|Bacteria,1RFHY@1224|Proteobacteria,2U8QB@28211|Alphaproteobacteria,3JYWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD1_k127_1729483_6	1144275.COCOR_00870	8.729e-57	200.0	COG0251@1|root,COG0251@2|Bacteria,1MYEM@1224|Proteobacteria	1224|Proteobacteria	J	Translation initiation inhibitor, yjgF family	-	-	3.5.99.5	ko:K15067	ko00380,map00380	-	R03887	RC01015	ko00000,ko00001,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_1729483_7	296591.Bpro_3363	2.447e-42	160.0	COG5580@1|root,COG5580@2|Bacteria,1NMBI@1224|Proteobacteria,2W5GZ@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_1729483_4	1267533.KB906736_gene966	2.305e-105	349.0	COG0412@1|root,COG0412@2|Bacteria,3Y8GG@57723|Acidobacteria	57723|Acidobacteria	Q	BAAT / Acyl-CoA thioester hydrolase C terminal	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1729483_9	1047013.AQSP01000131_gene1797	5.478e-29	132.0	COG0823@1|root,COG0823@2|Bacteria,2NPHZ@2323|unclassified Bacteria	2|Bacteria	U	WD40-like Beta Propeller Repeat	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD1_k127_1729483_1	1237149.C900_03217	5.609e-193	614.0	COG1012@1|root,COG1012@2|Bacteria,4NEB7@976|Bacteroidetes,47JKD@768503|Cytophagia	976|Bacteroidetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.32,1.2.1.85	ko:K00128,ko:K10217	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00362,ko00380,ko00410,ko00561,ko00620,ko00622,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00362,map00380,map00410,map00561,map00620,map00622,map00625,map00903,map00981,map01100,map01110,map01120,map01130,map01220	M00038,M00135,M00569	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02762,R02940,R02957,R03283,R03869,R03889,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R05353,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00254,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_1729483_0	1267534.KB906759_gene1889	4.174e-223	706.0	COG0671@1|root,COG0671@2|Bacteria,3Y6DG@57723|Acidobacteria	57723|Acidobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1729483_5	1183438.GKIL_0413	3.528e-57	216.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD1_k127_1729483_2	1267533.KB906740_gene247	1.688e-167	532.0	COG1234@1|root,COG1234@2|Bacteria,3Y7KR@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_183688_1	649638.Trad_1102	4.05e-182	581.0	COG1233@1|root,COG1233@2|Bacteria,1WM3K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	Q	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD1_k127_183688_10	497965.Cyan7822_2189	3.419e-13	82.0	COG1538@1|root,COG5373@1|root,COG1538@2|Bacteria,COG5373@2|Bacteria,1G0B8@1117|Cyanobacteria,3KGYW@43988|Cyanothece	1117|Cyanobacteria	MU	outer membrane efflux protein	-	-	-	ko:K03287	-	-	-	-	ko00000	1.B.17	-	-	OEP
HKD1_k127_183688_8	330214.NIDE1686	5.722e-59	220.0	COG0845@1|root,COG0845@2|Bacteria,3J13H@40117|Nitrospirae	40117|Nitrospirae	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_183688_0	1038860.AXAP01000007_gene6044	0.0	1326.0	COG0841@1|root,COG0841@2|Bacteria,1R93M@1224|Proteobacteria,2UP7I@28211|Alphaproteobacteria,3K354@41294|Bradyrhizobiaceae	2|Bacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_183688_5	1123073.KB899242_gene950	4.981e-74	265.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1X53Q@135614|Xanthomonadales	135614|Xanthomonadales	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_183688_3	497964.CfE428DRAFT_6528	2.714e-93	315.0	COG4275@1|root,COG4275@2|Bacteria	2|Bacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD1_k127_183688_6	176946.XP_007422076.1	1.055e-71	249.0	COG3340@1|root,2QR7X@2759|Eukaryota,39DGA@33154|Opisthokonta,3BC18@33208|Metazoa,3CWYN@33213|Bilateria,484TW@7711|Chordata,499CC@7742|Vertebrata	33208|Metazoa	E	Alpha-aspartyl dipeptidase-like	-	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD1_k127_183688_4	861299.J421_1374	3.588e-90	308.0	COG2423@1|root,COG2423@2|Bacteria	2|Bacteria	E	ornithine cyclodeaminase activity	ocd2	-	1.4.1.1,1.5.1.25,4.3.1.12	ko:K01750,ko:K18258,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000,ko04147	-	-	-	OCD_Mu_crystall
HKD1_k127_183688_9	1042877.GQS_00390	7.601e-37	145.0	COG4275@1|root,arCOG10427@2157|Archaea,2XXPQ@28890|Euryarchaeota,244YW@183968|Thermococci	183968|Thermococci	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD1_k127_183688_7	1396141.BATP01000027_gene1050	2.25e-63	223.0	COG1280@1|root,COG1280@2|Bacteria,46W68@74201|Verrucomicrobia,2IVKQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD1_k127_183688_2	269482.Bcep1808_6110	1.951e-103	345.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2VZIM@28216|Betaproteobacteria,1K4M4@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD1_k127_2067_3	1396418.BATQ01000120_gene3056	5.149e-38	144.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia,2ITM1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_2067_1	497964.CfE428DRAFT_1154	3.709e-55	197.0	2E56P@1|root,32ZZD@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3302)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3302
HKD1_k127_2067_0	497964.CfE428DRAFT_1155	2.439e-178	563.0	COG1566@1|root,COG1566@2|Bacteria,46TG9@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2
HKD1_k127_2067_2	497964.CfE428DRAFT_1156	1.58e-48	178.0	COG1538@1|root,COG1538@2|Bacteria,46UF0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_2099149_4	478741.JAFS01000002_gene900	2.02e-36	139.0	COG0581@1|root,COG0581@2|Bacteria,46T8D@74201|Verrucomicrobia,37GCU@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Binding-protein-dependent transport system inner membrane component	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_2099149_1	1156937.MFUM_300006	1.214e-111	366.0	COG1117@1|root,COG1117@2|Bacteria,46SB2@74201|Verrucomicrobia,37G7T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_2099149_2	1403819.BATR01000162_gene5405	2.266e-58	212.0	COG0704@1|root,COG0704@2|Bacteria,46SUX@74201|Verrucomicrobia,2IUGT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	PhoU domain	-	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_2099149_0	1156937.MFUM_1030014	9.098e-254	803.0	COG0855@1|root,COG0855@2|Bacteria,46SB4@74201|Verrucomicrobia,37GEJ@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_2099149_3	1038859.AXAU01000001_gene3555	5.858e-40	151.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2TSPZ@28211|Alphaproteobacteria,3JRYQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GK	Transcriptional regulator sugar kinase	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_2100153_5	497964.CfE428DRAFT_1881	4.508e-120	405.0	COG0815@1|root,COG0815@2|Bacteria,46SPW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD1_k127_2100153_1	59374.Fisuc_0111	2.2e-157	503.0	COG3876@1|root,COG3876@2|Bacteria	2|Bacteria	G	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD1_k127_2100153_14	557599.MKAN_19080	2.431e-58	214.0	COG1656@1|root,COG1656@2|Bacteria,2GMQR@201174|Actinobacteria,23528@1762|Mycobacteriaceae	201174|Actinobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD1_k127_2100153_3	1163407.UU7_05648	1.796e-138	464.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,1SYR1@1236|Gammaproteobacteria,1XCSI@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_2100153_16	1500894.JQNN01000001_gene4471	3.972e-29	130.0	2AHCA@1|root,317P0@2|Bacteria,1PZ1J@1224|Proteobacteria,2W33I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	S1/P1 Nuclease	-	-	-	-	-	-	-	-	-	-	-	-	S1-P1_nuclease
HKD1_k127_2100153_15	771875.Ferpe_1363	3.494e-50	182.0	COG1490@1|root,COG1490@2|Bacteria,2GCYQ@200918|Thermotogae	200918|Thermotogae	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD1_k127_2100153_2	404380.Gbem_1114	8.492e-141	469.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HKD1_k127_2100153_9	234267.Acid_2317	8.719e-82	283.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD1_k127_2100153_4	622637.KE124772_gene80	1.669e-121	391.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2TT09@28211|Alphaproteobacteria,36ZM7@31993|Methylocystaceae	28211|Alphaproteobacteria	O	C-terminal domain of 1-Cys peroxiredoxin	MA20_35715	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_2100153_10	237368.SCABRO_00637	9.707e-79	271.0	COG3228@1|root,COG3228@2|Bacteria,2IZES@203682|Planctomycetes	203682|Planctomycetes	S	Belongs to the MtfA family	-	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90,SEC-C
HKD1_k127_2100153_13	574087.Acear_1028	4.532e-65	236.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,3WA8M@53433|Halanaerobiales	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_2100153_0	497964.CfE428DRAFT_5976	0.0	1269.0	COG0542@1|root,COG0542@2|Bacteria,46S4S@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_2100153_8	497964.CfE428DRAFT_6174	7.412e-94	323.0	COG0477@1|root,COG2814@2|Bacteria,46T1N@74201|Verrucomicrobia	74201|Verrucomicrobia	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_2100153_6	497964.CfE428DRAFT_1667	1.248e-108	361.0	COG1082@1|root,COG1082@2|Bacteria,46SWH@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_2100153_11	497964.CfE428DRAFT_1665	1.196e-78	275.0	COG0392@1|root,COG0392@2|Bacteria,46T31@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD1_k127_2100153_12	497964.CfE428DRAFT_1664	3.694e-65	230.0	COG1985@1|root,COG1985@2|Bacteria,46WC6@74201|Verrucomicrobia	74201|Verrucomicrobia	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_2100153_7	497964.CfE428DRAFT_0879	1.988e-98	329.0	COG3494@1|root,COG3494@2|Bacteria,46SJ6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HKD1_k127_2106691_1	243231.GSU1897	3.232e-11	72.0	COG0775@1|root,COG0775@2|Bacteria,1Q1C0@1224|Proteobacteria,43EX0@68525|delta/epsilon subdivisions,2WRFZ@28221|Deltaproteobacteria,43V4A@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	PFAM purine or other phosphorylase family 1	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_2106691_0	497964.CfE428DRAFT_3838	3.243e-34	144.0	COG2911@1|root,COG2911@2|Bacteria,46TSK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	-	-	-	-	-	-	-	-	-	TamB
HKD1_k127_211342_5	497964.CfE428DRAFT_2161	3.973e-79	273.0	COG0726@1|root,COG0726@2|Bacteria,46UKH@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD1_k127_211342_3	497964.CfE428DRAFT_5926	1.401e-112	374.0	COG3868@1|root,COG3868@2|Bacteria,46STS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_211342_6	497964.CfE428DRAFT_5928	8.261e-77	266.0	COG0414@1|root,COG0414@2|Bacteria,46SRN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD1_k127_211342_9	1267534.KB906758_gene2231	4.091e-57	207.0	2AI77@1|root,318MJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_211342_0	448385.sce6769	4.364e-232	725.0	COG3391@1|root,COG3391@2|Bacteria,1MXDX@1224|Proteobacteria,42Y5B@68525|delta/epsilon subdivisions,2WU9D@28221|Deltaproteobacteria,2Z155@29|Myxococcales	28221|Deltaproteobacteria	S	Selenium-binding protein	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56
HKD1_k127_211342_7	497964.CfE428DRAFT_5941	2.557e-76	261.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD1_k127_211342_4	1396418.BATQ01000017_gene4184	1.551e-87	296.0	29RX9@1|root,30D1E@2|Bacteria,46ZJJ@74201|Verrucomicrobia,2IV9H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_211342_2	572546.Arcpr_1207	5.126e-137	460.0	COG0463@1|root,COG0500@1|root,COG1216@1|root,arCOG01384@2157|Archaea,arCOG04220@2157|Archaea,arCOG04347@2157|Archaea	2157|Archaea	Q	Methyltransferase type 11	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_2,Glycos_transf_2,Methyltransf_11
HKD1_k127_211342_1	497964.CfE428DRAFT_3455	3.025e-206	661.0	COG0859@1|root,COG1560@1|root,COG0859@2|Bacteria,COG1560@2|Bacteria,46SSR@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	2.3.1.241	ko:K02517,ko:K02843	ko00540,ko01100,map00540,map01100	M00060,M00080	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9,Lip_A_acyltrans
HKD1_k127_211342_8	1396141.BATP01000003_gene4990	4.573e-62	216.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,46TXQ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
HKD1_k127_2127862_8	497964.CfE428DRAFT_0486	2.221e-71	246.0	COG0087@1|root,COG0087@2|Bacteria,46SQV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_2127862_7	497964.CfE428DRAFT_0487	9.281e-72	248.0	COG0088@1|root,COG0088@2|Bacteria,46SWJ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD1_k127_2127862_17	497964.CfE428DRAFT_0488	4.58e-30	127.0	COG0089@1|root,COG0089@2|Bacteria,46WBX@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD1_k127_2127862_1	497964.CfE428DRAFT_0489	1.301e-130	421.0	COG0090@1|root,COG0090@2|Bacteria,46S71@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_2127862_15	1156937.MFUM_870039	1.436e-42	157.0	COG0185@1|root,COG0185@2|Bacteria,46T4G@74201|Verrucomicrobia,37GV3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD1_k127_2127862_18	497964.CfE428DRAFT_0491	1.527e-29	128.0	2FI21@1|root,349UX@2|Bacteria,46W3I@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2127862_14	497964.CfE428DRAFT_0492	4.426e-43	163.0	COG0091@1|root,COG0091@2|Bacteria,46T5F@74201|Verrucomicrobia	74201|Verrucomicrobia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD1_k127_2127862_3	497964.CfE428DRAFT_0493	1.577e-109	357.0	COG0092@1|root,COG0092@2|Bacteria,46SN9@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD1_k127_2127862_6	497964.CfE428DRAFT_0494	5.83e-74	250.0	COG0197@1|root,COG0197@2|Bacteria,46ST6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD1_k127_2127862_21	497964.CfE428DRAFT_0495	4.721e-15	77.0	COG0255@1|root,COG0255@2|Bacteria,46TAV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal L29 protein	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD1_k127_2127862_19	497964.CfE428DRAFT_0496	1.434e-27	114.0	COG0186@1|root,COG0186@2|Bacteria,46T6M@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD1_k127_2127862_10	497964.CfE428DRAFT_0497	1.782e-57	202.0	COG0093@1|root,COG0093@2|Bacteria,46VID@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD1_k127_2127862_20	497964.CfE428DRAFT_0498	1.901e-26	113.0	COG0198@1|root,COG0198@2|Bacteria,46T3M@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD1_k127_2127862_4	497964.CfE428DRAFT_0499	4.561e-78	265.0	COG0094@1|root,COG0094@2|Bacteria,46SP7@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD1_k127_2127862_12	497964.CfE428DRAFT_0500	3.213e-52	188.0	COG0096@1|root,COG0096@2|Bacteria,46T2K@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD1_k127_2127862_5	497964.CfE428DRAFT_0501	4.879e-74	253.0	COG0097@1|root,COG0097@2|Bacteria,46SP9@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD1_k127_2127862_16	2423.NA23_0208125	1.754e-33	135.0	COG0256@1|root,COG0256@2|Bacteria,2GD32@200918|Thermotogae	200918|Thermotogae	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008097,GO:0015934,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0097159,GO:1901363,GO:1990904	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD1_k127_2127862_9	497964.CfE428DRAFT_0503	3.724e-66	230.0	COG0098@1|root,COG0098@2|Bacteria,46SUR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD1_k127_2127862_11	497964.CfE428DRAFT_0504	3.085e-53	194.0	COG0200@1|root,COG0200@2|Bacteria,46SSX@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD1_k127_2127862_0	497964.CfE428DRAFT_0505	9.455e-227	712.0	COG0201@1|root,COG0201@2|Bacteria,46S86@74201|Verrucomicrobia	74201|Verrucomicrobia	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD1_k127_2127862_13	1317124.DW2_06393	7.362e-47	176.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2XM3X@285107|Thioclava	28211|Alphaproteobacteria	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD1_k127_2127862_2	497964.CfE428DRAFT_0506	2.159e-120	391.0	COG0024@1|root,COG0024@2|Bacteria,46SK6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_2157911_4	497964.CfE428DRAFT_0878	4.146e-69	238.0	2CNXM@1|root,32SI1@2|Bacteria,46SZC@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2157911_6	448385.sce7303	8.373e-64	236.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,43ENH@68525|delta/epsilon subdivisions,2X242@28221|Deltaproteobacteria,2Z170@29|Myxococcales	28221|Deltaproteobacteria	C	Tryptophan halogenase	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
HKD1_k127_2157911_0	395964.KE386496_gene1205	5.673e-140	450.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria,3NBQ4@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD1_k127_2157911_1	1448389.BAVQ01000002_gene2942	5.055e-127	432.0	COG1233@1|root,COG1233@2|Bacteria,2GJ80@201174|Actinobacteria	201174|Actinobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD1_k127_2157911_3	497964.CfE428DRAFT_4829	6.125e-103	340.0	COG0767@1|root,COG0767@2|Bacteria,46SY3@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_2157911_2	497964.CfE428DRAFT_4828	3.372e-105	348.0	COG1127@1|root,COG1127@2|Bacteria,46V71@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_2157911_5	497964.CfE428DRAFT_4827	3.622e-66	239.0	COG1463@1|root,COG1463@2|Bacteria	2|Bacteria	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD,OmpA
HKD1_k127_2166535_16	456442.Mboo_0933	4.036e-49	192.0	COG0218@1|root,arCOG00355@2157|Archaea	2157|Archaea	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
HKD1_k127_2166535_10	497964.CfE428DRAFT_4273	2.731e-131	426.0	COG1493@1|root,COG1493@2|Bacteria,46S64@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD1_k127_2166535_18	497964.CfE428DRAFT_4274	3.519e-35	136.0	COG1925@1|root,COG1925@2|Bacteria,46T6C@74201|Verrucomicrobia	74201|Verrucomicrobia	G	TIGRFAM phosphocarrier, HPr family	fruB	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD1_k127_2166535_8	278957.ABEA03000149_gene4043	1.555e-173	562.0	COG1080@1|root,COG1080@2|Bacteria,46TX4@74201|Verrucomicrobia,3K7JG@414999|Opitutae	414999|Opitutae	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_2166535_15	497964.CfE428DRAFT_1741	9.918e-63	219.0	COG1259@1|root,COG1259@2|Bacteria,46SW6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD1_k127_2166535_1	497964.CfE428DRAFT_1743	2.19e-300	932.0	COG1166@1|root,COG1166@2|Bacteria,46S4T@74201|Verrucomicrobia	74201|Verrucomicrobia	E	arginine decarboxylase	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD1_k127_2166535_20	479431.Namu_2249	3.765e-07	61.0	COG1073@1|root,COG1073@2|Bacteria,2IA0F@201174|Actinobacteria	201174|Actinobacteria	S	Hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD1_k127_2166535_6	234267.Acid_4533	5.714e-191	604.0	COG1520@1|root,COG1520@2|Bacteria,3Y2H2@57723|Acidobacteria	57723|Acidobacteria	S	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ_3
HKD1_k127_2166535_3	452637.Oter_3724	5.699e-246	765.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	GO:0000166,GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSDY_1059.SDY_2327	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_2166535_12	234267.Acid_7851	9.889e-127	431.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2166535_19	357808.RoseRS_0779	1.149e-33	149.0	COG1807@1|root,COG1807@2|Bacteria,2G8TF@200795|Chloroflexi,377RQ@32061|Chloroflexia	32061|Chloroflexia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_2166535_2	497964.CfE428DRAFT_3359	7.3e-295	913.0	COG0539@1|root,COG0539@2|Bacteria,46SFY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD1_k127_2166535_17	452637.Oter_1509	1.498e-39	153.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin,Thioredoxin,Thioredoxin_8
HKD1_k127_2166535_4	1183438.GKIL_3014	8.298e-204	644.0	COG0031@1|root,COG0031@2|Bacteria,1G0T4@1117|Cyanobacteria	1117|Cyanobacteria	E	cysteine synthase	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD1_k127_2166535_7	1183438.GKIL_3015	2.224e-183	580.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria	1117|Cyanobacteria	E	cystathionine	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD1_k127_2166535_9	1173263.Syn7502_00999	2.613e-162	520.0	COG0082@1|root,COG0082@2|Bacteria,1G12S@1117|Cyanobacteria,1GYWY@1129|Synechococcus	1117|Cyanobacteria	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	GO:0000166,GO:0003674,GO:0003824,GO:0004107,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009423,GO:0009987,GO:0010181,GO:0016053,GO:0016829,GO:0016835,GO:0016838,GO:0019438,GO:0019752,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046417,GO:0048037,GO:0050662,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.aroC	Chorismate_synt
HKD1_k127_2166535_5	1403819.BATR01000031_gene1031	6.784e-193	613.0	COG0064@1|root,COG0064@2|Bacteria,46S5X@74201|Verrucomicrobia,2ITJA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_2166535_13	497964.CfE428DRAFT_0543	1.521e-94	324.0	COG1929@1|root,COG1929@2|Bacteria	2|Bacteria	G	organic acid phosphorylation	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD1_k127_2166535_14	497964.CfE428DRAFT_0226	1.495e-63	226.0	COG0663@1|root,COG0663@2|Bacteria	2|Bacteria	G	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_2166535_0	497964.CfE428DRAFT_3887	0.0	1127.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,46VK0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_2166535_11	857087.Metme_1559	1.102e-130	426.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1XE2N@135618|Methylococcales	135618|Methylococcales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_2239668_10	204669.Acid345_2966	5.326e-114	380.0	COG2079@1|root,COG2079@2|Bacteria,3Y5N1@57723|Acidobacteria,2JK64@204432|Acidobacteriia	204432|Acidobacteriia	S	MmgE/PrpD family	-	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD1_k127_2239668_3	1396418.BATQ01000049_gene427	8.059e-213	673.0	COG1012@1|root,COG1012@2|Bacteria,46TX0@74201|Verrucomicrobia,2IUT7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD1_k127_2239668_6	1403819.BATR01000093_gene2833	1.133e-176	565.0	COG0160@1|root,COG0160@2|Bacteria	2|Bacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lat	-	2.6.1.11,2.6.1.17,2.6.1.19,2.6.1.22,2.6.1.36	ko:K00821,ko:K03918,ko:K07250,ko:K13524	ko00220,ko00250,ko00280,ko00300,ko00410,ko00640,ko00650,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,ko04727,map00220,map00250,map00280,map00300,map00410,map00640,map00650,map01100,map01110,map01120,map01130,map01210,map01230,map04727	M00016,M00027,M00028,M00845	R00457,R00908,R01648,R02283,R04188,R04475	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iNJ661.Rv3290c	Aminotran_3
HKD1_k127_2239668_2	497964.CfE428DRAFT_5143	1.477e-233	739.0	COG1960@1|root,COG1960@2|Bacteria,46TJY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_2239668_5	497964.CfE428DRAFT_5144	3.617e-183	597.0	COG1250@1|root,COG1250@2|Bacteria,46U5Q@74201|Verrucomicrobia	74201|Verrucomicrobia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD1_k127_2239668_0	1340493.JNIF01000004_gene135	0.0	1132.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria	57723|Acidobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_2239668_9	756067.MicvaDRAFT_2865	1.874e-115	381.0	COG2234@1|root,COG2234@2|Bacteria,1G1QW@1117|Cyanobacteria,1H7N7@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_2239668_13	1267534.KB906755_gene4489	3.314e-82	286.0	COG0842@1|root,COG0842@2|Bacteria,3Y4H7@57723|Acidobacteria,2JN2Y@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_2239668_8	661478.OP10G_2908	1.434e-115	380.0	COG1131@1|root,COG1131@2|Bacteria	2|Bacteria	V	ATPase activity	ybhF-C	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_2239668_19	909663.KI867150_gene2915	8.939e-30	130.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,43BPM@68525|delta/epsilon subdivisions,2X70W@28221|Deltaproteobacteria,2MSKN@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_2239668_15	706587.Desti_3800	5.536e-60	214.0	COG1309@1|root,COG1309@2|Bacteria,1NAQF@1224|Proteobacteria,42S96@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_2239668_22	338963.Pcar_3377	1.204e-17	90.0	2EMJ2@1|root,33F7N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2239668_18	335543.Sfum_1510	2.766e-34	142.0	2DQW0@1|root,3390A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2239668_1	497964.CfE428DRAFT_0990	1.108e-279	872.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM ATP-dependent DNA helicase, RecQ family	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
HKD1_k127_2239668_17	335543.Sfum_1510	5.639e-39	155.0	2DQW0@1|root,3390A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2239668_21	395961.Cyan7425_0783	4.994e-24	119.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G7ID@1117|Cyanobacteria,3KHZI@43988|Cyanothece	1117|Cyanobacteria	O	Peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,TPR_1,TPR_11,TPR_8,Trypsin_2
HKD1_k127_2239668_25	1280390.CBQR020000083_gene1798	6.082e-06	55.0	28Q2E@1|root,2ZCKD@2|Bacteria,1V260@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2239668_23	113395.AXAI01000018_gene4848	1.101e-15	87.0	COG2358@1|root,COG2358@2|Bacteria,1MXW1@1224|Proteobacteria,2TSK2@28211|Alphaproteobacteria,3JZ7W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	imp	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD1_k127_2239668_24	1396418.BATQ01000054_gene3	9.35e-13	71.0	2E3X5@1|root,32YUB@2|Bacteria,46WYM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknwon function (DUF3008)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3008
HKD1_k127_2239668_4	886293.Sinac_0988	4.573e-200	634.0	COG0531@1|root,COG0531@2|Bacteria,2IX7G@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_2239668_14	562970.Btus_2819	6.695e-77	265.0	COG1540@1|root,COG1540@2|Bacteria,1TR8X@1239|Firmicutes,4H9PF@91061|Bacilli,278U8@186823|Alicyclobacillaceae	91061|Bacilli	S	Belongs to the UPF0271 (lamB) family	ycsF	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
HKD1_k127_2239668_7	794903.OPIT5_04825	1.352e-127	428.0	COG1984@1|root,COG2049@1|root,COG1984@2|Bacteria,COG2049@2|Bacteria,46VNA@74201|Verrucomicrobia,3K9I8@414999|Opitutae	414999|Opitutae	E	Allophanate hydrolase subunit 2	-	-	-	-	-	-	-	-	-	-	-	-	CT_A_B
HKD1_k127_2239668_20	521098.Aaci_0861	6.018e-29	127.0	COG2353@1|root,COG2353@2|Bacteria,1V1NX@1239|Firmicutes,4HFXF@91061|Bacilli	91061|Bacilli	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_2239668_16	497964.CfE428DRAFT_4583	9.29e-55	197.0	COG1381@1|root,COG1381@2|Bacteria,46VUW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD1_k127_2239668_12	1128421.JAGA01000002_gene1937	1.974e-94	324.0	COG0477@1|root,COG2814@2|Bacteria,2NS3M@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_2239668_11	583355.Caka_1093	6.344e-106	350.0	COG1249@1|root,COG1249@2|Bacteria,46SJE@74201|Verrucomicrobia,3K7MT@414999|Opitutae	414999|Opitutae	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_2244253_2	113395.AXAI01000002_gene5313	2.756e-37	148.0	2EFWC@1|root,339NM@2|Bacteria,1NG7T@1224|Proteobacteria,2UY62@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2244253_3	278957.ABEA03000097_gene797	1.291e-08	61.0	2A1I4@1|root,30PRV@2|Bacteria,46XXK@74201|Verrucomicrobia,3K8JP@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2244253_1	497964.CfE428DRAFT_1388	6.669e-47	175.0	COG1595@1|root,COG1595@2|Bacteria,46STJ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_2244253_4	1382359.JIAL01000001_gene810	0.0003282	49.0	2EGII@1|root,33AAP@2|Bacteria,3Y5ST@57723|Acidobacteria,2JK57@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2244253_0	1122134.KB893650_gene1319	6.475e-82	278.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XJ36@135619|Oceanospirillales	135619|Oceanospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_2289443_1	1288494.EBAPG3_7100	8.956e-190	612.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,2VNQM@28216|Betaproteobacteria,372BI@32003|Nitrosomonadales	28216|Betaproteobacteria	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
HKD1_k127_2289443_6	330214.NIDE3514	7.779e-81	275.0	COG0546@1|root,COG0546@2|Bacteria,3J11X@40117|Nitrospirae	40117|Nitrospirae	S	phosphoglycolate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2289443_2	1123393.KB891326_gene93	2.408e-140	456.0	COG0282@1|root,COG0282@2|Bacteria,1MW61@1224|Proteobacteria,2VHRC@28216|Betaproteobacteria,1KRJW@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Acetokinase family	-	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD1_k127_2289443_8	522306.CAP2UW1_0135	1.223e-46	171.0	2BYGX@1|root,32U2R@2|Bacteria,1RCK4@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2289443_0	357808.RoseRS_0827	4.126e-291	909.0	COG1523@1|root,COG1523@2|Bacteria,2G86B@200795|Chloroflexi,3763Y@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_2289443_5	1396141.BATP01000039_gene1324	1.046e-89	304.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia,2ITGC@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_2289443_4	1379270.AUXF01000007_gene997	1.638e-90	309.0	COG2819@1|root,COG2819@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD1_k127_2289443_3	351160.RCIX2633	4.232e-101	340.0	COG0604@1|root,arCOG01458@2157|Archaea,2XURG@28890|Euryarchaeota,2N9N6@224756|Methanomicrobia	224756|Methanomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_2289443_7	497964.CfE428DRAFT_4351	2.71e-72	254.0	COG0583@1|root,COG0583@2|Bacteria,46TTX@74201|Verrucomicrobia	74201|Verrucomicrobia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_2289443_9	1286093.C266_24700	1.261e-41	162.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2VH7G@28216|Betaproteobacteria,1KG43@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_2312441_2	649638.Trad_1405	7.962e-14	77.0	COG1597@1|root,COG1597@2|Bacteria,1WMEH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM Diacylglycerol kinase, catalytic	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD1_k127_2312441_0	497964.CfE428DRAFT_3965	2.762e-143	474.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD1_k127_2312441_1	1185876.BN8_00648	2.161e-54	196.0	COG4244@1|root,COG4244@2|Bacteria,4NPHV@976|Bacteroidetes,47PWW@768503|Cytophagia	976|Bacteroidetes	S	Predicted membrane protein (DUF2231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD1_k127_2335388_1	204669.Acid345_1883	1.554e-132	432.0	COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_2335388_2	497964.CfE428DRAFT_0598	5.847e-82	276.0	COG0512@1|root,COG0512@2|Bacteria,46SN1@74201|Verrucomicrobia	74201|Verrucomicrobia	EH	PFAM glutamine amidotransferase class-I	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_2335388_0	1396418.BATQ01000155_gene2459	1.976e-154	505.0	COG0147@1|root,COG0147@2|Bacteria,46S4I@74201|Verrucomicrobia,2ITH7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EH	Anthranilate synthase component I, N terminal region	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_2335388_3	246194.CHY_1585	1.001e-34	139.0	COG0547@1|root,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_2349633_5	1123234.AUKI01000011_gene1083	4.049e-25	106.0	COG0606@1|root,COG0606@2|Bacteria,4NE0G@976|Bacteroidetes,1HXWB@117743|Flavobacteriia	976|Bacteroidetes	O	magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_2349633_3	497964.CfE428DRAFT_0350	1.161e-57	204.0	COG1666@1|root,COG1666@2|Bacteria,46VRB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF520)	-	-	-	-	-	-	-	-	-	-	-	-	DUF520
HKD1_k127_2349633_1	497964.CfE428DRAFT_5940	1.363e-70	246.0	COG1496@1|root,COG1496@2|Bacteria,46STZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Multi-copper polyphenol oxidoreductase laccase	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_2349633_2	497964.CfE428DRAFT_5939	1.069e-57	221.0	COG1538@1|root,COG1538@2|Bacteria,46T0P@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_2349633_4	497964.CfE428DRAFT_5937	6.938e-45	169.0	COG1846@1|root,COG1846@2|Bacteria,46VKR@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_2349633_0	1168065.DOK_05770	3.457e-79	278.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1J4IQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	COG0303 Molybdopterin biosynthesis enzyme	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD1_k127_2372295_0	452637.Oter_4432	0.0	1680.0	COG3696@1|root,COG3696@2|Bacteria,46SJ1@74201|Verrucomicrobia,3K7EV@414999|Opitutae	414999|Opitutae	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD1_k127_2372295_4	452637.Oter_4431	8.535e-145	475.0	COG0845@1|root,COG0845@2|Bacteria,46SVD@74201|Verrucomicrobia,3K8NI@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07798	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1	-	-	DUF3347,HlyD_D23
HKD1_k127_2372295_12	497964.CfE428DRAFT_2704	2.452e-91	316.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_2372295_22	864051.BurJ1DRAFT_1279	9.449e-18	94.0	2AJKK@1|root,31A7Q@2|Bacteria,1N0ZI@1224|Proteobacteria,2VXXW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD1_k127_2372295_14	1040989.AWZU01000003_gene6761	5.576e-83	286.0	28HTF@1|root,2Z80A@2|Bacteria,1PEXH@1224|Proteobacteria,2TTDP@28211|Alphaproteobacteria,3JWDE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2372295_21	671143.DAMO_1907	3.426e-26	112.0	COG2372@1|root,COG2372@2|Bacteria	2|Bacteria	C	response to copper ion	-	-	-	ko:K07156,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC,CopD
HKD1_k127_2372295_19	522306.CAP2UW1_1519	1.044e-31	127.0	COG4828@1|root,COG4828@2|Bacteria,1N984@1224|Proteobacteria,2W60I@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD1_k127_2372295_18	1396141.BATP01000013_gene2682	3.856e-36	141.0	COG0736@1|root,COG0736@2|Bacteria,46T5U@74201|Verrucomicrobia,2IUTE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	4'-phosphopantetheinyl transferase superfamily	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_2372295_13	497964.CfE428DRAFT_2062	2.21e-89	301.0	COG0854@1|root,COG0854@2|Bacteria,46SJT@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD1_k127_2372295_17	370438.PTH_0128	4.488e-40	159.0	COG1216@1|root,COG1216@2|Bacteria,1UJRW@1239|Firmicutes,25F86@186801|Clostridia,262I4@186807|Peptococcaceae	186801|Clostridia	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_2372295_20	643867.Ftrac_0650	3.107e-31	128.0	COG1305@1|root,COG1305@2|Bacteria,4NKII@976|Bacteroidetes,47KZ3@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_2372295_10	866536.Belba_1144	5.843e-96	323.0	COG1305@1|root,COG1305@2|Bacteria,4NKII@976|Bacteroidetes,47KZ3@768503|Cytophagia	976|Bacteroidetes	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_2372295_11	1123278.KB893477_gene3638	2.707e-95	320.0	COG3000@1|root,COG3000@2|Bacteria,4NES7@976|Bacteroidetes,47PZF@768503|Cytophagia	976|Bacteroidetes	I	Fatty acid hydroxylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_2372295_5	1267533.KB906733_gene2975	1.227e-135	441.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HKD1_k127_2372295_9	595460.RRSWK_02055	1.598e-111	370.0	COG0535@1|root,COG0535@2|Bacteria,2IXC0@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3641)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Radical_SAM
HKD1_k127_2372295_15	1173028.ANKO01000020_gene5455	1.333e-64	230.0	COG0500@1|root,COG2226@2|Bacteria,1G3QN@1117|Cyanobacteria,1H9TM@1150|Oscillatoriales	1117|Cyanobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_2372295_16	1210884.HG799466_gene12574	1.806e-42	161.0	2EDAV@1|root,33776@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2372295_6	1210884.HG799466_gene12573	2.889e-123	399.0	COG0479@1|root,COG0479@2|Bacteria,2J136@203682|Planctomycetes	203682|Planctomycetes	C	2Fe-2S iron-sulfur cluster binding domain	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD1_k127_2372295_1	204669.Acid345_1384	1.061e-296	919.0	COG1053@1|root,COG1053@2|Bacteria,3Y6IU@57723|Acidobacteria,2JKAD@204432|Acidobacteriia	204432|Acidobacteriia	C	Fumarate reductase flavoprotein C-term	-	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_2372295_7	1210884.HG799466_gene12570	8.027e-121	392.0	2CEY7@1|root,2Z8CG@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2372295_3	525897.Dbac_1167	1.384e-216	680.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria,2MA27@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Rhodanese domain protein	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_2372295_8	1121381.JNIV01000020_gene3267	3.894e-116	384.0	COG2041@1|root,COG2041@2|Bacteria,1WI25@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM Mo-co oxidoreductase dimerisation domain	-	-	-	ko:K17225	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD1_k127_2372295_23	1210884.HG799468_gene13549	8.844e-16	82.0	COG2140@1|root,COG2140@2|Bacteria,2IWYT@203682|Planctomycetes	203682|Planctomycetes	G	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1
HKD1_k127_2372295_2	84531.JMTZ01000094_gene649	9.942e-265	830.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,1RZRK@1236|Gammaproteobacteria,1X4X1@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_2372295_24	1396418.BATQ01000142_gene3310	4.861e-12	68.0	2DFF9@1|root,2ZRMT@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_2376389_7	251221.35211765	8.724e-123	414.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2376389_2	452637.Oter_1883	5.533e-175	578.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_2376389_3	251221.35211765	1.388e-172	570.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2376389_9	452637.Oter_1900	3.966e-111	363.0	COG1136@1|root,COG1136@2|Bacteria,46TVQ@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2376389_6	452637.Oter_1901	2.702e-135	447.0	COG0845@1|root,COG0845@2|Bacteria,46UK7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2376389_5	234267.Acid_4169	1.714e-154	499.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD1_k127_2376389_4	926566.Terro_2393	4.8e-156	510.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_2376389_8	481448.Minf_2378	2.482e-117	389.0	COG1633@1|root,COG1814@1|root,COG1633@2|Bacteria,COG1814@2|Bacteria,46WTS@74201|Verrucomicrobia,37G3H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin,VIT1
HKD1_k127_2376389_11	1227739.Hsw_3882	2.976e-77	271.0	COG0697@1|root,COG0697@2|Bacteria,4NGJR@976|Bacteroidetes,47N5J@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_2376389_12	1267535.KB906767_gene508	7.326e-23	100.0	COG2261@1|root,COG2261@2|Bacteria,3Y5KH@57723|Acidobacteria,2JNHS@204432|Acidobacteriia	204432|Acidobacteriia	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_2376389_1	497964.CfE428DRAFT_5481	1.08e-228	719.0	COG1052@1|root,COG1052@2|Bacteria,46SAN@74201|Verrucomicrobia	74201|Verrucomicrobia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD1_k127_2376389_10	1267533.KB906733_gene3151	4.41e-104	347.0	2CDI3@1|root,3416N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2376389_0	497964.CfE428DRAFT_0232	3.483e-237	749.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2421313_0	243231.GSU0371	2.912e-178	576.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_2421313_1	1209989.TepiRe1_2193	2.72e-70	251.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,42F00@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_2421313_2	595460.RRSWK_04758	7.698e-36	141.0	2E5WH@1|root,32RS6@2|Bacteria	2|Bacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_2640821_12	497964.CfE428DRAFT_0012	0.0002758	45.0	COG0304@1|root,COG0304@2|Bacteria,46SKK@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_2640821_6	497964.CfE428DRAFT_6673	5.08e-34	134.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_2640821_9	497964.CfE428DRAFT_6154	5.02e-17	88.0	COG0389@1|root,COG0389@2|Bacteria,46SR8@74201|Verrucomicrobia	74201|Verrucomicrobia	L	impB/mucB/samB family	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS,IMS_C
HKD1_k127_2640821_7	452637.Oter_4055	2.443e-32	134.0	COG0468@1|root,COG0468@2|Bacteria,46ZHW@74201|Verrucomicrobia,3KA1M@414999|Opitutae	414999|Opitutae	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2640821_3	1123070.KB899254_gene1274	9.276e-62	221.0	COG1974@1|root,COG1974@2|Bacteria,46SU8@74201|Verrucomicrobia,2IU8D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	LexA DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD1_k127_2640821_1	497964.CfE428DRAFT_2970	9.003e-103	340.0	2F4YG@1|root,33XKC@2|Bacteria,46VC2@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2640821_10	525903.Taci_0792	3.175e-09	61.0	COG0695@1|root,COG0695@2|Bacteria,3TBJF@508458|Synergistetes	508458|Synergistetes	O	TIGRFAM Glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_2640821_0	497964.CfE428DRAFT_2481	6.632e-242	757.0	COG0442@1|root,COG0442@2|Bacteria,46SE3@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HKD1_k127_2640821_2	497964.CfE428DRAFT_0563	5.563e-69	239.0	COG0102@1|root,COG0102@2|Bacteria,46VEU@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_2640821_4	497964.CfE428DRAFT_0564	4.574e-50	182.0	COG0103@1|root,COG0103@2|Bacteria,46SXI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_2640821_5	497964.CfE428DRAFT_4168	3.981e-39	155.0	COG1729@1|root,COG1729@2|Bacteria	2|Bacteria	S	protein trimerization	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_21,TPR_6
HKD1_k127_2640821_8	937777.Deipe_1929	1.148e-30	135.0	COG2323@1|root,COG2323@2|Bacteria	2|Bacteria	K	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD1_k127_2659251_1	497964.CfE428DRAFT_4701	1.671e-75	255.0	COG0482@1|root,COG0482@2|Bacteria,46SQW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_2659251_2	497964.CfE428DRAFT_0750	5.919e-58	207.0	COG2094@1|root,COG2094@2|Bacteria,46VAR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Methylpurine-DNA glycosylase (MPG)	-	-	-	-	-	-	-	-	-	-	-	-	Pur_DNA_glyco
HKD1_k127_2659251_4	1449049.JONW01000005_gene1088	6.702e-05	53.0	COG0810@1|root,COG0810@2|Bacteria	2|Bacteria	M	energy transducer activity	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,Peptidase_M56,TonB_C
HKD1_k127_2659251_0	1396141.BATP01000022_gene358	2.933e-112	382.0	COG0737@1|root,COG0737@2|Bacteria,46X8F@74201|Verrucomicrobia,2IV06@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Calcineurin-like phosphoesterase	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HKD1_k127_2659251_3	1218076.BAYB01000008_gene1505	1.005e-25	109.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VNG1@28216|Betaproteobacteria,1KH5I@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Berberine and berberine like	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD1_k127_2757311_1	240015.ACP_2101	3.14e-71	248.0	2E27Y@1|root,32XE5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3419
HKD1_k127_2757311_0	402777.KB235904_gene3597	0.0	1102.0	COG1042@1|root,COG1670@1|root,COG1042@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1H81U@1150|Oscillatoriales	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_2838863_5	204669.Acid345_2293	5.407e-34	138.0	COG3301@1|root,COG3301@2|Bacteria,3Y506@57723|Acidobacteria,2JN1H@204432|Acidobacteriia	204432|Acidobacteriia	P	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_2838863_1	404380.Gbem_2180	1.7e-97	328.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,42RAW@68525|delta/epsilon subdivisions,2WMX4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4
HKD1_k127_2838863_0	204669.Acid345_2291	0.0	1048.0	COG0243@1|root,COG3383@1|root,COG0243@2|Bacteria,COG3383@2|Bacteria,3Y47M@57723|Acidobacteria,2JKQK@204432|Acidobacteriia	204432|Acidobacteriia	C	Molydopterin dinucleotide binding domain	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Molybdopterin,Molydop_binding
HKD1_k127_2838863_2	204669.Acid345_2290	1.511e-74	255.0	COG3383@1|root,COG3383@2|Bacteria	2|Bacteria	C	formate dehydrogenase (NAD+) activity	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03470	Fer2_4,Fer4,Fer4_21,Fer4_7
HKD1_k127_2838863_4	497964.CfE428DRAFT_3333	2.38e-58	218.0	COG1565@1|root,COG1565@2|Bacteria,46T7F@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD1_k127_2838863_3	497964.CfE428DRAFT_1453	4.655e-60	217.0	COG0744@1|root,COG0744@2|Bacteria,46U6K@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM glycosyl transferase family 51	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_2900889_0	452637.Oter_2609	2.252e-155	504.0	COG0591@1|root,COG0591@2|Bacteria,46UEN@74201|Verrucomicrobia,3K9NP@414999|Opitutae	414999|Opitutae	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HKD1_k127_2900889_2	452637.Oter_2608	2.778e-113	371.0	2F12M@1|root,33U44@2|Bacteria,46V6U@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2900889_3	452637.Oter_2607	2.042e-99	332.0	COG2120@1|root,COG2120@2|Bacteria,46V8X@74201|Verrucomicrobia	74201|Verrucomicrobia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_2900889_1	452637.Oter_2606	9.139e-152	487.0	COG0438@1|root,COG0438@2|Bacteria,46WYS@74201|Verrucomicrobia,3K9XP@414999|Opitutae	414999|Opitutae	M	PFAM glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glycos_transf_1
HKD1_k127_3024834_11	497964.CfE428DRAFT_4653	3.76e-140	451.0	COG1199@1|root,COG1199@2|Bacteria,46SCS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	SMART helicase c2	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_2,Helicase_C_2,ResIII
HKD1_k127_3024834_24	497964.CfE428DRAFT_0220	6.359e-83	288.0	COG0795@1|root,COG0795@2|Bacteria,46T0M@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM permease YjgP YjgQ family protein	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD1_k127_3024834_30	497964.CfE428DRAFT_0221	1.124e-47	176.0	2EKW2@1|root,33EJK@2|Bacteria,46VZV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3024834_29	497964.CfE428DRAFT_1749	8.86e-51	182.0	COG0316@1|root,COG0316@2|Bacteria,46T1T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD1_k127_3024834_27	497964.CfE428DRAFT_6695	1.693e-70	243.0	COG0233@1|root,COG0233@2|Bacteria,46V49@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD1_k127_3024834_21	497964.CfE428DRAFT_6694	2.84e-97	325.0	COG0528@1|root,COG0528@2|Bacteria,46S4W@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_3024834_23	497964.CfE428DRAFT_1670	2.767e-95	322.0	COG0223@1|root,COG0223@2|Bacteria,46SKS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD1_k127_3024834_36	706587.Desti_2842	2.637e-14	75.0	2EUYT@1|root,33NE0@2|Bacteria,1P79U@1224|Proteobacteria,432X2@68525|delta/epsilon subdivisions,2WXB8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3024834_25	497964.CfE428DRAFT_1669	3.257e-82	277.0	COG0563@1|root,COG0563@2|Bacteria,46SW4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK
HKD1_k127_3024834_32	497964.CfE428DRAFT_6605	7.883e-40	152.0	COG0211@1|root,COG0211@2|Bacteria,46T48@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD1_k127_3024834_34	1122137.AQXF01000003_gene1939	5.474e-28	118.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
HKD1_k127_3024834_6	497964.CfE428DRAFT_4577	3.34e-170	547.0	COG0297@1|root,COG0297@2|Bacteria,46S9F@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_3024834_4	497964.CfE428DRAFT_2107	1.693e-187	595.0	COG0617@1|root,COG0617@2|Bacteria,46S8B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Poly A polymerase head domain	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD1_k127_3024834_31	497964.CfE428DRAFT_0796	7.626e-44	164.0	COG0597@1|root,COG0597@2|Bacteria,46TCC@74201|Verrucomicrobia	74201|Verrucomicrobia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD1_k127_3024834_0	497964.CfE428DRAFT_0797	0.0	1159.0	COG0060@1|root,COG0060@2|Bacteria,46SEC@74201|Verrucomicrobia	74201|Verrucomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD1_k127_3024834_1	497964.CfE428DRAFT_2637	0.0	1149.0	COG0567@1|root,COG0567@2|Bacteria,46S6G@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM 2-oxoglutarate dehydrogenase, E1 subunit	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD1_k127_3024834_13	497964.CfE428DRAFT_2303	6.751e-134	437.0	COG0265@1|root,COG0265@2|Bacteria,46TR9@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3024834_18	478741.JAFS01000001_gene1163	2.103e-109	363.0	COG1131@1|root,COG1131@2|Bacteria,46UAZ@74201|Verrucomicrobia,37GF1@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_3024834_28	497964.CfE428DRAFT_2300	6.206e-59	213.0	COG1277@1|root,COG1277@2|Bacteria,46T0W@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-2 family transporter protein	nosY	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_3
HKD1_k127_3024834_19	497964.CfE428DRAFT_2298	1.1e-105	360.0	COG3225@1|root,COG3225@2|Bacteria,46SRK@74201|Verrucomicrobia	74201|Verrucomicrobia	N	ABC-type uncharacterized transport system	gldG	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
HKD1_k127_3024834_8	497964.CfE428DRAFT_2297	7.704e-152	501.0	2DN50@1|root,32VJ4@2|Bacteria,46V62@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
HKD1_k127_3024834_39	907348.TresaDRAFT_2416	2.413e-06	56.0	COG3209@1|root,COG3209@2|Bacteria,2J7HK@203691|Spirochaetes	203691|Spirochaetes	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3024834_35	497964.CfE428DRAFT_2942	5.093e-16	84.0	COG2001@1|root,COG2001@2|Bacteria,46T5G@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_3024834_22	497964.CfE428DRAFT_2941	5.666e-97	327.0	COG0275@1|root,COG0275@2|Bacteria,46SPT@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_3024834_14	481448.Minf_1417	7.453e-132	441.0	COG0768@1|root,COG0768@2|Bacteria,46SEZ@74201|Verrucomicrobia,37G10@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	D	Penicillin binding protein transpeptidase domain	-	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_3024834_3	497964.CfE428DRAFT_2939	4.255e-195	619.0	COG0768@1|root,COG0769@1|root,COG0768@2|Bacteria,COG0769@2|Bacteria,46SGG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3024834_9	497964.CfE428DRAFT_2938	4.63e-144	471.0	COG0770@1|root,COG0770@2|Bacteria,46SDF@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3024834_15	478741.JAFS01000001_gene1129	6.35e-129	421.0	COG0472@1|root,COG0472@2|Bacteria,46SD0@74201|Verrucomicrobia,37GBT@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD1_k127_3024834_7	497964.CfE428DRAFT_2936	1.181e-152	497.0	COG0771@1|root,COG0771@2|Bacteria,46UUH@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_3024834_38	497964.CfE428DRAFT_2935	1.903e-12	76.0	COG1388@1|root,COG1388@2|Bacteria,46T90@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_3024834_20	1396418.BATQ01000080_gene767	4.611e-98	332.0	COG0772@1|root,COG0772@2|Bacteria,46SMC@74201|Verrucomicrobia,2ITN2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Cell cycle protein	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_3024834_16	497964.CfE428DRAFT_2933	2.024e-123	405.0	COG0707@1|root,COG0707@2|Bacteria,46S84@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_3024834_2	497964.CfE428DRAFT_2932	2.803e-297	932.0	COG0773@1|root,COG0812@1|root,COG0773@2|Bacteria,COG0812@2|Bacteria,46SCG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation	murB	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4,MurB_C,Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3024834_17	497964.CfE428DRAFT_2930	3.958e-116	382.0	COG1181@1|root,COG1181@2|Bacteria,46UZ2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_3024834_26	497964.CfE428DRAFT_2929	1.131e-72	263.0	COG1589@1|root,COG1589@2|Bacteria,46T4T@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD1_k127_3024834_5	497964.CfE428DRAFT_2928	9.088e-185	584.0	COG0849@1|root,COG0849@2|Bacteria,46SQI@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD1_k127_3024834_12	497964.CfE428DRAFT_2927	5.065e-134	441.0	COG0206@1|root,COG0206@2|Bacteria,46UWD@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_3024834_10	215803.DB30_3749	5.127e-141	462.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,42NR8@68525|delta/epsilon subdivisions,2WM9T@28221|Deltaproteobacteria,2YXV5@29|Myxococcales	28221|Deltaproteobacteria	M	Peptidase dimerisation domain	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3024834_33	1125863.JAFN01000001_gene3390	9.769e-32	133.0	COG0417@1|root,COG0417@2|Bacteria,1MVY9@1224|Proteobacteria,42Q4K@68525|delta/epsilon subdivisions,2WKQ1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DNA polymerase type-B family	polB	-	2.7.7.7	ko:K02336	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol_B,DNA_pol_B_exo1,RNase_H_2
HKD1_k127_3047173_26	42256.RradSPS_2313	1.181e-28	120.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_3047173_20	1501230.ET33_35580	1.325e-48	179.0	COG1670@1|root,COG1670@2|Bacteria,1VQDG@1239|Firmicutes,4HHTI@91061|Bacilli,272NM@186822|Paenibacillaceae	91061|Bacilli	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_3047173_32	743721.Psesu_0008	2.196e-05	55.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S7VF@1236|Gammaproteobacteria,1X54J@135614|Xanthomonadales	135614|Xanthomonadales	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB1	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_3047173_21	1121413.JMKT01000010_gene852	5.651e-45	166.0	COG0824@1|root,COG0824@2|Bacteria,1RI3X@1224|Proteobacteria,42SW5@68525|delta/epsilon subdivisions,2WW97@28221|Deltaproteobacteria,2MBHH@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Acyl-ACP thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
HKD1_k127_3047173_9	497964.CfE428DRAFT_6325	2.756e-122	403.0	COG0438@1|root,COG0438@2|Bacteria,46TH7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3047173_29	292564.Cyagr_1513	3.194e-20	96.0	COG2373@1|root,COG2373@2|Bacteria	2|Bacteria	U	Large extracellular alpha-helical protein	-	-	-	-	-	-	-	-	-	-	-	-	Coa1,Rib
HKD1_k127_3047173_31	376686.Fjoh_2329	5.352e-07	53.0	COG2373@1|root,COG2373@2|Bacteria,4NSQZ@976|Bacteroidetes,1I45X@117743|Flavobacteriia,2NW7U@237|Flavobacterium	976|Bacteroidetes	S	Cytochrome oxidase complex assembly protein 1	-	-	-	-	-	-	-	-	-	-	-	-	Coa1
HKD1_k127_3047173_2	497964.CfE428DRAFT_2604	4.724e-156	498.0	COG0489@1|root,COG0489@2|Bacteria,46SAV@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD1_k127_3047173_28	497964.CfE428DRAFT_2605	3.252e-22	98.0	2E99J@1|root,333HQ@2|Bacteria,46T77@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4032
HKD1_k127_3047173_18	497964.CfE428DRAFT_2606	6.621e-59	209.0	COG2065@1|root,COG2065@2|Bacteria,46VY6@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphoribosyl transferase domain	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	-	Pribosyltran
HKD1_k127_3047173_6	497964.CfE428DRAFT_2607	1.491e-147	473.0	COG0540@1|root,COG0540@2|Bacteria,46S9E@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_3047173_0	497964.CfE428DRAFT_2609	1.111e-187	596.0	COG0044@1|root,COG0044@2|Bacteria,46S78@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_3047173_22	1267534.KB906754_gene3574	1.542e-43	164.0	COG2905@1|root,COG2905@2|Bacteria,3Y5NG@57723|Acidobacteria	57723|Acidobacteria	T	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_3047173_25	391589.RGAI101_3935	4.962e-32	138.0	COG4424@1|root,COG4424@2|Bacteria,1N77D@1224|Proteobacteria,2TW4Z@28211|Alphaproteobacteria,2P3TN@2433|Roseobacter	28211|Alphaproteobacteria	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_3047173_23	1173026.Glo7428_0086	2.216e-42	160.0	COG1733@1|root,COG1733@2|Bacteria,1G84R@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_3047173_10	1173026.Glo7428_0087	6.045e-118	389.0	COG0265@1|root,COG0265@2|Bacteria,1G3M4@1117|Cyanobacteria	1117|Cyanobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3047173_7	555079.Toce_1497	7.838e-140	460.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,42FB3@68295|Thermoanaerobacterales	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_3047173_15	497964.CfE428DRAFT_2563	1.383e-79	279.0	COG0793@1|root,COG0793@2|Bacteria,46VYN@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HKD1_k127_3047173_13	1123070.KB899254_gene1231	1.517e-85	289.0	COG0571@1|root,COG0571@2|Bacteria,46T3X@74201|Verrucomicrobia,2IU7S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD1_k127_3047173_16	497964.CfE428DRAFT_2565	1.622e-78	271.0	COG0351@1|root,COG0351@2|Bacteria,46SVN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_3047173_24	481448.Minf_1147	3.082e-38	145.0	COG1141@1|root,COG1141@2|Bacteria,46T2D@74201|Verrucomicrobia,37GX8@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	4Fe-4S single cluster domain of Ferredoxin I	-	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13
HKD1_k127_3047173_17	868595.Desca_0806	3.954e-69	245.0	COG0730@1|root,COG0730@2|Bacteria,1UI7C@1239|Firmicutes,24DK7@186801|Clostridia	186801|Clostridia	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_3047173_27	1128421.JAGA01000003_gene3187	3.572e-25	118.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3047173_12	497964.CfE428DRAFT_3566	2.129e-99	334.0	COG2220@1|root,COG2220@2|Bacteria,46UV4@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_3047173_14	497964.CfE428DRAFT_3335	2.33e-84	292.0	COG1686@1|root,COG1686@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S11
HKD1_k127_3047173_19	497964.CfE428DRAFT_6146	3.385e-56	199.0	COG0346@1|root,COG0346@2|Bacteria,46SUF@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_4
HKD1_k127_3047173_4	945713.IALB_1287	1.137e-148	477.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3047173_3	945713.IALB_1286	6.356e-153	491.0	COG2170@1|root,COG2170@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD1_k127_3047173_1	497964.CfE428DRAFT_2289	2.706e-182	580.0	COG0593@1|root,COG0593@2|Bacteria,46S6H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_3047173_5	1123070.KB899248_gene118	1.482e-148	481.0	COG0592@1|root,COG0592@2|Bacteria,46SPK@74201|Verrucomicrobia,2ITMH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD1_k127_3047173_8	926550.CLDAP_30780	3.243e-127	416.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G719@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HKD1_k127_3047173_11	497964.CfE428DRAFT_0829	1.206e-103	346.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	fixC	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
HKD1_k127_3063493_0	497964.CfE428DRAFT_2152	1.908e-204	648.0	COG0621@1|root,COG0621@2|Bacteria,46S5U@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_3063493_4	497964.CfE428DRAFT_2471	1.081e-33	138.0	COG3118@1|root,COG3118@2|Bacteria,46VWK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_3063493_10	1150469.RSPPHO_02781	7.105e-05	46.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3063493_3	497964.CfE428DRAFT_0567	4.195e-46	168.0	COG0335@1|root,COG0335@2|Bacteria,46T0S@74201|Verrucomicrobia	74201|Verrucomicrobia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD1_k127_3063493_2	497964.CfE428DRAFT_0568	2.191e-75	259.0	COG0164@1|root,COG0164@2|Bacteria,46SXH@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_3063493_5	1403819.BATR01000125_gene4479	1.582e-29	123.0	COG0792@1|root,COG0792@2|Bacteria,46T9J@74201|Verrucomicrobia,2IUV7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Uncharacterised protein family UPF0102	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD1_k127_3063493_7	1237149.C900_00771	5.225e-18	90.0	2EHC3@1|root,33B3Y@2|Bacteria,4NZPQ@976|Bacteroidetes,47WF2@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
HKD1_k127_3063493_1	1121920.AUAU01000020_gene2550	2.377e-202	642.0	COG0433@1|root,COG0433@2|Bacteria,3Y69X@57723|Acidobacteria	57723|Acidobacteria	S	Bacterial protein of unknown function (DUF853)	-	-	-	-	-	-	-	-	-	-	-	-	DUF853
HKD1_k127_3063493_6	497964.CfE428DRAFT_4531	1.146e-25	109.0	2CFNS@1|root,331AJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3066472_3	497964.CfE428DRAFT_2596	2.767e-15	77.0	COG0402@1|root,COG0402@2|Bacteria,46TB5@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_3066472_0	497964.CfE428DRAFT_2602	2.133e-188	599.0	COG1508@1|root,COG1508@2|Bacteria,46SDZ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma-54 factor, RpoN	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_3066472_2	234267.Acid_5566	1.31e-25	115.0	COG0428@1|root,COG0428@2|Bacteria,3Y8C3@57723|Acidobacteria	57723|Acidobacteria	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3066472_1	1449065.JMLL01000011_gene2169	2.896e-91	309.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TSE3@28211|Alphaproteobacteria,43J8F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux
HKD1_k127_3120293_28	497964.CfE428DRAFT_0335	2.368e-97	329.0	COG1092@1|root,COG1092@2|Bacteria,46SYW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD1_k127_3120293_82	1396141.BATP01000007_gene5705	0.0008714	46.0	COG1633@1|root,COG1633@2|Bacteria	2|Bacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	DUF2383
HKD1_k127_3120293_58	926554.KI912633_gene3824	1.007e-26	112.0	COG3360@1|root,COG3360@2|Bacteria,1WKKK@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_3120293_14	497964.CfE428DRAFT_2495	9.4e-152	489.0	COG0162@1|root,COG0162@2|Bacteria,46S76@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD1_k127_3120293_32	497964.CfE428DRAFT_0819	9.161e-91	304.0	COG0047@1|root,COG0047@2|Bacteria,46T5R@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_3120293_61	497964.CfE428DRAFT_0821	5.397e-23	101.0	COG1828@1|root,COG1828@2|Bacteria,46WNB@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD1_k127_3120293_3	330214.NIDE3191	1.067e-282	885.0	COG3408@1|root,COG3408@2|Bacteria,3J0Z8@40117|Nitrospirae	40117|Nitrospirae	G	Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N_bis
HKD1_k127_3120293_13	667014.Thein_1524	3.791e-152	487.0	COG0438@1|root,COG0438@2|Bacteria,2GHNP@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3120293_22	497964.CfE428DRAFT_4309	4.163e-113	376.0	COG1793@1|root,COG1793@2|Bacteria,46S9X@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_3120293_40	452637.Oter_4309	3.664e-68	240.0	COG1793@1|root,COG1793@2|Bacteria,46S9X@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase Ligase (LigD)	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_3120293_36	240016.ABIZ01000001_gene737	1.303e-75	259.0	COG0264@1|root,COG0264@2|Bacteria,46SUK@74201|Verrucomicrobia,2IU52@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD1_k127_3120293_25	497964.CfE428DRAFT_2906	1.306e-107	353.0	COG0052@1|root,COG0052@2|Bacteria,46SNG@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_3120293_60	402626.Rpic_1885	1.434e-23	111.0	2E4Z6@1|root,32ZSW@2|Bacteria,1N6U2@1224|Proteobacteria,2VW9R@28216|Betaproteobacteria,1K8VF@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_43	1122604.JONR01000010_gene3879	3.067e-67	239.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RNMZ@1236|Gammaproteobacteria,1X42D@135614|Xanthomonadales	135614|Xanthomonadales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD1_k127_3120293_46	497964.CfE428DRAFT_2687	1.414e-61	216.0	COG4659@1|root,COG4659@2|Bacteria	2|Bacteria	C	FMN binding	rnfG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
HKD1_k127_3120293_45	1335760.ASTG01000008_gene972	1.543e-63	229.0	COG3637@1|root,COG3637@2|Bacteria,1PW82@1224|Proteobacteria,2U8GW@28211|Alphaproteobacteria,2K6DC@204457|Sphingomonadales	204457|Sphingomonadales	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_51	497964.CfE428DRAFT_3450	4.994e-55	199.0	COG2096@1|root,COG2096@2|Bacteria,46T1G@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cobalamin adenosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Cob_adeno_trans
HKD1_k127_3120293_0	497964.CfE428DRAFT_5595	0.0	2258.0	COG0086@1|root,COG0086@2|Bacteria,46S79@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD1_k127_3120293_1	497964.CfE428DRAFT_5596	0.0	2186.0	COG0085@1|root,COG0085@2|Bacteria,46S8Q@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_3120293_53	497964.CfE428DRAFT_5603	2.4e-45	168.0	COG0222@1|root,COG0222@2|Bacteria,46SWC@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD1_k127_3120293_54	240016.ABIZ01000001_gene4935	7.473e-43	162.0	COG0244@1|root,COG0244@2|Bacteria,46T4Q@74201|Verrucomicrobia,2IUF1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD1_k127_3120293_24	497964.CfE428DRAFT_5605	2.277e-109	358.0	COG0081@1|root,COG0081@2|Bacteria,46S7K@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD1_k127_3120293_44	945713.IALB_2399	4.728e-66	250.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K13687	-	-	-	-	ko00000,ko01000,ko01003	-	GT89	-	DUF2723,PMT_2
HKD1_k127_3120293_17	1096930.L284_12450	3.532e-125	423.0	COG2936@1|root,COG2936@2|Bacteria,1R2BJ@1224|Proteobacteria,2TZGD@28211|Alphaproteobacteria,2K5IN@204457|Sphingomonadales	204457|Sphingomonadales	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S15
HKD1_k127_3120293_80	269797.Mbar_A1627	0.000478	52.0	COG3291@1|root,arCOG03383@1|root,arCOG02510@2157|Archaea,arCOG03383@2157|Archaea	2157|Archaea	E	COG1506 Dipeptidyl aminopeptidases acylaminoacyl-peptidases	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CBM_6,NosD,PD40,PKD
HKD1_k127_3120293_9	639030.JHVA01000001_gene188	6.616e-164	539.0	COG4805@1|root,COG4805@2|Bacteria,3Y71M@57723|Acidobacteria,2JKC6@204432|Acidobacteriia	204432|Acidobacteriia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_3120293_42	497964.CfE428DRAFT_5631	1.476e-67	231.0	COG0080@1|root,COG0080@2|Bacteria,46SPZ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD1_k127_3120293_34	1396141.BATP01000023_gene539	1.462e-85	286.0	COG0250@1|root,COG0250@2|Bacteria,46SR6@74201|Verrucomicrobia,2IU6S@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	In Spt5p, this domain may confer affinity for Spt4p. It possesses a RNP-like fold.	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD1_k127_3120293_62	497964.CfE428DRAFT_5633	2.762e-21	96.0	COG0690@1|root,COG0690@2|Bacteria,46T9W@74201|Verrucomicrobia	74201|Verrucomicrobia	U	SecE/Sec61-gamma subunits of protein translocation complex	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD1_k127_3120293_6	240016.ABIZ01000001_gene4940	1.538e-218	681.0	COG0050@1|root,COG0050@2|Bacteria,46SFG@74201|Verrucomicrobia,2ITQE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_3120293_65	63737.Npun_R4596	1.818e-20	103.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1HKUX@1161|Nostocales	1117|Cyanobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
HKD1_k127_3120293_78	1225184.ALXE01000001_gene2954	2.306e-08	66.0	COG0697@1|root,COG0697@2|Bacteria,1MWSU@1224|Proteobacteria,1RSF8@1236|Gammaproteobacteria,3VZ0U@53335|Pantoea	1236|Gammaproteobacteria	EG	Transporter	yyaM	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3120293_19	497964.CfE428DRAFT_2718	8.175e-119	388.0	COG0142@1|root,COG0142@2|Bacteria,46S62@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_3120293_23	497964.CfE428DRAFT_2716	2.171e-112	373.0	COG0533@1|root,COG0533@2|Bacteria,46SEH@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_3120293_12	497964.CfE428DRAFT_2715	7.418e-154	497.0	COG0793@1|root,COG0793@2|Bacteria,46SM7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_3120293_7	1270193.JARP01000002_gene697	6.625e-195	625.0	COG4805@1|root,COG4805@2|Bacteria,4NFAK@976|Bacteroidetes,1HXAT@117743|Flavobacteriia,2NV5I@237|Flavobacterium	976|Bacteroidetes	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_3120293_2	240016.ABIZ01000001_gene4121	0.0	1112.0	COG0842@1|root,COG1131@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,46TJ4@74201|Verrucomicrobia,2ITSH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran
HKD1_k127_3120293_16	497964.CfE428DRAFT_2401	3.452e-132	431.0	COG0006@1|root,COG0006@2|Bacteria,46SKG@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the peptidase M24B family	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_3120293_50	452637.Oter_3489	1.368e-57	208.0	COG2738@1|root,COG2738@2|Bacteria,46THF@74201|Verrucomicrobia,3K7WD@414999|Opitutae	414999|Opitutae	S	Putative neutral zinc metallopeptidase	-	-	-	ko:K06973	-	-	-	-	ko00000	-	-	-	Zn_peptidase_2
HKD1_k127_3120293_30	497964.CfE428DRAFT_2400	3.823e-93	310.0	COG1595@1|root,COG1595@2|Bacteria,46SWN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_3120293_35	497964.CfE428DRAFT_2398	1.846e-85	294.0	COG0265@1|root,COG0265@2|Bacteria,46T0K@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3120293_11	85643.Tmz1t_3869	1.127e-159	523.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VPV3@28216|Betaproteobacteria	28216|Betaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD1_k127_3120293_49	1037409.BJ6T_24570	3.573e-59	211.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TRJB@28211|Alphaproteobacteria,3K5X9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_3120293_4	1396141.BATP01000005_gene6065	1.892e-227	725.0	COG0272@1|root,COG0272@2|Bacteria,46TMK@74201|Verrucomicrobia,2ITPR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	-	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD1_k127_3120293_10	497964.CfE428DRAFT_6149	8.851e-164	538.0	COG2103@1|root,COG2971@1|root,COG2103@2|Bacteria,COG2971@2|Bacteria,46SJI@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,SIS_2
HKD1_k127_3120293_64	525897.Dbac_2186	4.511e-21	94.0	2DRFV@1|root,33BJD@2|Bacteria,1NM2T@1224|Proteobacteria,42WGX@68525|delta/epsilon subdivisions,2WR8G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_55	1134912.AJTV01000061_gene3984	1.43e-42	166.0	COG4872@1|root,COG4872@2|Bacteria,1N3FM@1224|Proteobacteria	1224|Proteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HKD1_k127_3120293_63	1134912.AJTV01000061_gene3984	3.436e-21	102.0	COG4872@1|root,COG4872@2|Bacteria,1N3FM@1224|Proteobacteria	1224|Proteobacteria	S	Predicted membrane protein (DUF2157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2157
HKD1_k127_3120293_57	398512.JQKC01000036_gene4811	8.503e-27	117.0	COG4929@1|root,COG4929@2|Bacteria,1UPRT@1239|Firmicutes,24NGM@186801|Clostridia,3WPNH@541000|Ruminococcaceae	186801|Clostridia	S	GDYXXLXY protein	-	-	-	-	-	-	-	-	-	-	-	-	GDYXXLXY
HKD1_k127_3120293_20	497964.CfE428DRAFT_3399	6.819e-118	396.0	COG0265@1|root,COG0265@2|Bacteria,46SHP@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3120293_37	497964.CfE428DRAFT_1211	4.585e-75	271.0	COG0666@1|root,COG1376@1|root,COG0666@2|Bacteria,COG1376@2|Bacteria,46VM6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Ankyrin repeats (3 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,YkuD
HKD1_k127_3120293_5	886293.Sinac_1862	7.245e-221	704.0	COG2234@1|root,COG2234@2|Bacteria,2IWTP@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_3120293_59	204669.Acid345_3466	1.051e-23	101.0	2DS5Y@1|root,33EPX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_31	1121939.L861_17460	6.766e-91	302.0	COG4430@1|root,COG4430@2|Bacteria,1RJGC@1224|Proteobacteria,1S853@1236|Gammaproteobacteria,1XK0S@135619|Oceanospirillales	135619|Oceanospirillales	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
HKD1_k127_3120293_77	443598.AUFA01000013_gene6543	2.03e-08	56.0	2C4SR@1|root,32TC7@2|Bacteria,1RCZG@1224|Proteobacteria,2U89H@28211|Alphaproteobacteria,3JZY4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_41	404589.Anae109_3083	9.76e-68	236.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,42SGK@68525|delta/epsilon subdivisions,2WPDI@28221|Deltaproteobacteria,2YVW1@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_4,Abhydrolase_5,DLH
HKD1_k127_3120293_39	240292.Ava_0532	1.821e-68	243.0	COG0395@1|root,COG0395@2|Bacteria,1G1XU@1117|Cyanobacteria,1HM9X@1161|Nostocales	1117|Cyanobacteria	G	PFAM Inward rectifier potassium channel	-	-	-	ko:K08715	-	-	-	-	ko00000,ko02000	1.A.2.2	-	-	IRK
HKD1_k127_3120293_56	1454004.AW11_02570	1.879e-27	113.0	COG4274@1|root,COG4274@2|Bacteria,1MZVV@1224|Proteobacteria,2VUPM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM GYD family protein	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_3120293_27	497964.CfE428DRAFT_6076	3.664e-100	331.0	COG5530@1|root,COG5530@2|Bacteria	2|Bacteria	S	Predicted integral membrane protein (DUF2270)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2270
HKD1_k127_3120293_74	240016.ABIZ01000001_gene4134	2.571e-12	73.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN	GO:0001932,GO:0001934,GO:0003674,GO:0003824,GO:0004857,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006810,GO:0008047,GO:0008150,GO:0008643,GO:0009401,GO:0009893,GO:0010033,GO:0010243,GO:0010562,GO:0010604,GO:0015144,GO:0016020,GO:0016740,GO:0016772,GO:0016773,GO:0019207,GO:0019209,GO:0019220,GO:0019222,GO:0019887,GO:0022804,GO:0022857,GO:0022898,GO:0030234,GO:0030295,GO:0031323,GO:0031325,GO:0031399,GO:0031401,GO:0032147,GO:0032268,GO:0032270,GO:0032409,GO:0032412,GO:0032879,GO:0033674,GO:0034219,GO:0034762,GO:0034765,GO:0042221,GO:0042325,GO:0042327,GO:0043085,GO:0043086,GO:0043269,GO:0043549,GO:0044092,GO:0044093,GO:0044424,GO:0044444,GO:0044464,GO:0045859,GO:0045860,GO:0045937,GO:0048518,GO:0048522,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051049,GO:0051171,GO:0051173,GO:0051174,GO:0051179,GO:0051234,GO:0051246,GO:0051247,GO:0051338,GO:0051347,GO:0055085,GO:0060255,GO:0065007,GO:0065009,GO:0071702,GO:0071944,GO:0080090,GO:0090563,GO:0098772,GO:1901698	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
HKD1_k127_3120293_26	497964.CfE428DRAFT_6105	2.265e-102	340.0	COG1235@1|root,COG1235@2|Bacteria,46SKU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_3120293_72	1005048.CFU_3651	1.643e-13	76.0	COG1555@1|root,COG1555@2|Bacteria,1PWEB@1224|Proteobacteria,2WBYZ@28216|Betaproteobacteria,4784S@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	photosystem II stabilization	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_33	497964.CfE428DRAFT_6588	3.122e-88	297.0	COG1028@1|root,COG1028@2|Bacteria,46SNA@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short,adh_short_C2
HKD1_k127_3120293_66	1267533.KB906733_gene2848	1.837e-20	96.0	2E32R@1|root,32Y2Y@2|Bacteria,3Y5RV@57723|Acidobacteria,2JNI4@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_15	497964.CfE428DRAFT_6589	1.693e-134	438.0	COG1703@1|root,COG2185@1|root,COG1703@2|Bacteria,COG2185@2|Bacteria,46TIM@74201|Verrucomicrobia	74201|Verrucomicrobia	E	TIGRFAM LAO AO transport system ATPase	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding
HKD1_k127_3120293_18	1120972.AUMH01000015_gene1333	3.662e-122	414.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4HCMS@91061|Bacilli,27812@186823|Alicyclobacillaceae	91061|Bacilli	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0006139,GO:0006163,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009117,GO:0009150,GO:0009259,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016866,GO:0017076,GO:0017111,GO:0019001,GO:0019637,GO:0019693,GO:0019842,GO:0031419,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0034784,GO:0035383,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046906,GO:0046983,GO:0047727,GO:0048037,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:0097159,GO:0097367,GO:1901135,GO:1901265,GO:1901360,GO:1901363,GO:1901564	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD1_k127_3120293_73	1173022.Cri9333_2967	2.273e-13	76.0	COG1943@1|root,COG1943@2|Bacteria,1G5Y7@1117|Cyanobacteria,1HCR7@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_3120293_67	497964.CfE428DRAFT_4320	3.375e-16	84.0	291K5@1|root,2ZP6G@2|Bacteria,46WPQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3120293_29	697282.Mettu_4021	1.042e-94	317.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria,1XGED@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_3120293_47	525897.Dbac_3076	8.71e-60	216.0	COG1573@1|root,COG1573@2|Bacteria,1RBA6@1224|Proteobacteria,42S3B@68525|delta/epsilon subdivisions,2WNST@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
HKD1_k127_3120293_21	497964.CfE428DRAFT_2620	2.002e-116	379.0	COG0330@1|root,COG0330@2|Bacteria,46VDU@74201|Verrucomicrobia	74201|Verrucomicrobia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_3120293_8	497964.CfE428DRAFT_4707	7.228e-184	580.0	COG1060@1|root,COG1060@2|Bacteria	2|Bacteria	H	7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity	mqnC	GO:0003674,GO:0003824,GO:0006732,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016740,GO:0016765,GO:0044237,GO:0044249,GO:0044689,GO:0051186,GO:0051188	1.21.98.1,2.5.1.77	ko:K11779,ko:K11780,ko:K11781,ko:K11784	ko00130,ko00680,ko01110,ko01120,map00130,map00680,map01110,map01120	M00378	R08588,R09396	RC01381,RC02329,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_3120293_48	1116232.AHBF01000072_gene9132	2.958e-59	218.0	COG0665@1|root,COG0665@2|Bacteria,2GN2M@201174|Actinobacteria	201174|Actinobacteria	E	Glycine D-amino acid oxidases (deaminating)	-	-	1.4.3.3	ko:K00273	ko00260,ko00311,ko00330,ko00472,ko01100,ko01130,ko04146,map00260,map00311,map00330,map00472,map01100,map01130,map04146	-	R00366,R02457,R02894,R02923,R04221,R07400	RC00006,RC00018,RC00135	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_3120293_52	1173022.Cri9333_4684	2.638e-50	186.0	COG2032@1|root,COG2032@2|Bacteria,1G9Z6@1117|Cyanobacteria,1HD5U@1150|Oscillatoriales	1117|Cyanobacteria	P	Copper/zinc superoxide dismutase (SODC)	-	-	1.15.1.1	ko:K04565	ko04146,ko04213,ko05014,ko05016,ko05020,map04146,map04213,map05014,map05016,map05020	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Cu
HKD1_k127_3120293_81	1444306.JFZC01000028_gene2219	0.0005003	45.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,4H9S5@91061|Bacilli,26PAH@186821|Sporolactobacillaceae	91061|Bacilli	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_3124641_3	452637.Oter_1975	6.372e-23	102.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia,3K8JJ@414999|Opitutae	414999|Opitutae	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_3124641_0	497964.CfE428DRAFT_4028	4.27e-164	532.0	COG0728@1|root,COG0728@2|Bacteria,46SH1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD1_k127_3124641_1	926550.CLDAP_04670	3.542e-41	154.0	COG0626@1|root,COG0626@2|Bacteria,2G5M2@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism pyridoxal-phosphate-dependent protein	-	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_3170732_2	472759.Nhal_1647	1.944e-30	125.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD1_k127_3170732_3	439235.Dalk_3992	1.722e-11	76.0	2EPTW@1|root,33HED@2|Bacteria,1NK6N@1224|Proteobacteria,4312Q@68525|delta/epsilon subdivisions,2WWWG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3170732_1	118163.Ple7327_0643	7.712e-140	452.0	COG2843@1|root,COG2843@2|Bacteria,1G20Q@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Bacterial capsule synthesis protein PGA_cap	-	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD1_k127_3170732_0	224325.AF_1664	3.881e-211	672.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,245VM@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
HKD1_k127_3170732_4	1396141.BATP01000023_gene685	7.778e-07	53.0	COG1913@1|root,COG1913@2|Bacteria,46WX0@74201|Verrucomicrobia,2IVPQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Peptidase family M54	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M54
HKD1_k127_3178519_0	452637.Oter_1890	2.491e-230	735.0	COG0577@1|root,COG0577@2|Bacteria,46UZM@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_3178519_1	234267.Acid_6478	5.018e-93	312.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_3178519_3	661478.OP10G_4489	3.905e-18	91.0	2A52F@1|root,30TQU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3178519_2	234267.Acid_3242	3.226e-66	235.0	COG0577@1|root,COG0577@2|Bacteria,3Y6E4@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_3209819_13	1500893.JQNB01000001_gene789	2.168e-11	71.0	COG3305@1|root,COG3305@2|Bacteria,1RKBI@1224|Proteobacteria,1S6AE@1236|Gammaproteobacteria,1X74U@135614|Xanthomonadales	135614|Xanthomonadales	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
HKD1_k127_3209819_10	794903.OPIT5_09785	1.916e-29	122.0	COG0346@1|root,COG0346@2|Bacteria,46VWA@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3209819_3	497964.CfE428DRAFT_2160	1.322e-132	428.0	COG0005@1|root,COG0005@2|Bacteria,46UP8@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PNP_UDP_1
HKD1_k127_3209819_1	497964.CfE428DRAFT_3537	5.628e-199	630.0	COG0621@1|root,COG0621@2|Bacteria,46S6B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_3209819_8	497964.CfE428DRAFT_3563	1.27e-41	159.0	2EEN4@1|root,338G1@2|Bacteria,46T5X@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3209819_4	497964.CfE428DRAFT_1693	4.387e-95	320.0	COG0859@1|root,COG0859@2|Bacteria,46SZK@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_3209819_2	497964.CfE428DRAFT_2042	3.336e-157	501.0	COG1087@1|root,COG1087@2|Bacteria,46SIR@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_3209819_9	497964.CfE428DRAFT_2043	1.222e-34	139.0	COG3584@1|root,COG3584@2|Bacteria	2|Bacteria	T	3D domain protein	yocH	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	3D,LysM,NLPC_P60,Peptidase_M23
HKD1_k127_3209819_7	861299.J421_1569	2.581e-47	175.0	COG1970@1|root,COG1970@2|Bacteria,1ZTYT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_3209819_0	497964.CfE428DRAFT_5324	0.0	1250.0	COG0495@1|root,COG0495@2|Bacteria,46SF4@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_3209819_6	497964.CfE428DRAFT_5323	2.857e-57	205.0	COG0127@1|root,COG0127@2|Bacteria,46SZ5@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_3209819_12	481448.Minf_2323	8.182e-29	120.0	COG0848@1|root,COG0848@2|Bacteria,46W6Q@74201|Verrucomicrobia,37H8K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD1_k127_3209819_14	589865.DaAHT2_1557	2.034e-06	58.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,42VSU@68525|delta/epsilon subdivisions,2WR9P@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_3209819_11	481448.Minf_2323	5.496e-29	121.0	COG0848@1|root,COG0848@2|Bacteria,46W6Q@74201|Verrucomicrobia,37H8K@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD1_k127_3209819_5	478741.JAFS01000002_gene962	1.371e-66	241.0	COG0811@1|root,COG0811@2|Bacteria,46VD2@74201|Verrucomicrobia,37H3W@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD1_k127_3227655_40	1089550.ATTH01000001_gene293	1.654e-12	78.0	COG0628@1|root,COG0628@2|Bacteria,4NFHZ@976|Bacteroidetes,1FIXC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_3227655_34	760117.JN27_23445	2.82e-22	103.0	COG0664@1|root,COG0664@2|Bacteria,1N4C9@1224|Proteobacteria,2VVJC@28216|Betaproteobacteria,4761J@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_3227655_9	240016.ABIZ01000001_gene1053	3.691e-153	488.0	COG0451@1|root,COG0451@2|Bacteria,46S80@74201|Verrucomicrobia,2ITWW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	GDP-mannose 4,6 dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
HKD1_k127_3227655_13	1403819.BATR01000010_gene392	3.136e-123	403.0	COG0180@1|root,COG0180@2|Bacteria,46SA6@74201|Verrucomicrobia,2ITQN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	tRNA synthetases class I (W and Y)	-	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD1_k127_3227655_35	1336237.JAEE01000006_gene792	6.006e-18	89.0	COG4922@1|root,COG4922@2|Bacteria,1MYTU@1224|Proteobacteria,1SAR7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD1_k127_3227655_31	172088.AUGA01000059_gene4254	2.706e-28	116.0	COG3801@1|root,COG3801@2|Bacteria,1REJV@1224|Proteobacteria,2U8BB@28211|Alphaproteobacteria,3JYZ9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD1_k127_3227655_30	1282876.BAOK01000001_gene3354	5.67e-30	123.0	2C3PV@1|root,3307H@2|Bacteria,1N0Y3@1224|Proteobacteria,2UC7H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2834)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
HKD1_k127_3227655_36	1121035.AUCH01000009_gene791	1.971e-16	82.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,2VWDY@28216|Betaproteobacteria,2KX5K@206389|Rhodocyclales	206389|Rhodocyclales	S	DUF167	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD1_k127_3227655_22	1267533.KB906738_gene2292	1.877e-53	191.0	COG2044@1|root,COG2044@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
HKD1_k127_3227655_37	1120985.AUMI01000014_gene754	2.445e-15	87.0	COG1463@1|root,COG1463@2|Bacteria,1UI1N@1239|Firmicutes,4H3F6@909932|Negativicutes	909932|Negativicutes	Q	Virulence factor Mce family protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_3227655_15	497964.CfE428DRAFT_0101	2.006e-99	333.0	COG1127@1|root,COG1127@2|Bacteria,46SRC@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	ttg2A	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_3227655_17	497964.CfE428DRAFT_0100	4.539e-92	309.0	COG0767@1|root,COG0767@2|Bacteria,46SXR@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Permease MlaE	ttg2B	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_3227655_33	497964.CfE428DRAFT_0099	2.37e-25	113.0	2CGGY@1|root,2ZGNS@2|Bacteria,46WT0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3227655_27	497964.CfE428DRAFT_0019	1.181e-33	135.0	296GV@1|root,2ZTSD@2|Bacteria,46WKD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3227655_12	497964.CfE428DRAFT_4930	8.06e-124	403.0	COG4974@1|root,COG4974@2|Bacteria,46SQ4@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_3227655_3	247490.KSU1_C0312	6.9e-322	1004.0	COG0542@1|root,COG0542@2|Bacteria,2IXHI@203682|Planctomycetes	203682|Planctomycetes	O	with chaperone activity ATP-binding	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD1_k127_3227655_7	497964.CfE428DRAFT_3440	2.123e-164	524.0	COG3869@1|root,COG3869@2|Bacteria,46S55@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Protein-arginine kinase	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
HKD1_k127_3227655_19	497964.CfE428DRAFT_3441	7.324e-66	228.0	COG3880@1|root,COG3880@2|Bacteria,46SXX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM UvrB UvrC protein	mcsA	-	-	ko:K19411	-	-	-	-	ko00000	-	-	-	UVR
HKD1_k127_3227655_11	497964.CfE428DRAFT_3442	1e-125	410.0	COG0115@1|root,COG0115@2|Bacteria,46S9W@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_3227655_16	497964.CfE428DRAFT_3443	3.45e-98	324.0	COG1136@1|root,COG1136@2|Bacteria,46UQZ@74201|Verrucomicrobia	74201|Verrucomicrobia	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
HKD1_k127_3227655_42	1396418.BATQ01000142_gene3310	9.311e-09	66.0	2DFF9@1|root,2ZRMT@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_3227655_20	497964.CfE428DRAFT_3444	9.288e-60	209.0	COG0219@1|root,COG0219@2|Bacteria,46SYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	cspR	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_3227655_10	497964.CfE428DRAFT_0116	1.215e-136	442.0	COG0176@1|root,COG0176@2|Bacteria,46UAK@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	GO:0003674,GO:0003824,GO:0004801,GO:0016740,GO:0016744	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_3227655_39	1276756.AUEX01000003_gene718	6.11e-13	76.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_3227655_4	497964.CfE428DRAFT_5899	1.975e-206	653.0	COG4992@1|root,COG4992@2|Bacteria,46UBT@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-III	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_3227655_44	497964.CfE428DRAFT_6257	7.653e-07	56.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3227655_2	497964.CfE428DRAFT_0818	0.0	1029.0	COG0046@1|root,COG0046@2|Bacteria,46S8Y@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HKD1_k127_3227655_6	316067.Geob_2890	6.094e-165	532.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43UES@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD1_k127_3227655_8	497964.CfE428DRAFT_0621	2.56e-153	490.0	COG0150@1|root,COG0150@2|Bacteria,46SJ4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	AIR synthase related protein domain protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_3227655_0	497964.CfE428DRAFT_6300	0.0	1047.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,46SAC@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_72,Glycos_transf_2
HKD1_k127_3227655_5	497964.CfE428DRAFT_1556	9.574e-193	610.0	COG0001@1|root,COG0001@2|Bacteria,46S67@74201|Verrucomicrobia	74201|Verrucomicrobia	H	intramolecular transferase activity, transferring amino groups	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_3227655_24	204669.Acid345_1452	2.989e-43	164.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3227655_18	1396141.BATP01000060_gene4594	5.304e-74	267.0	COG1459@1|root,COG1459@2|Bacteria,46X1U@74201|Verrucomicrobia,2IU50@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II secretion system (T2SS), protein F	-	-	-	-	-	-	-	-	-	-	-	-	T2SSF
HKD1_k127_3227655_26	497964.CfE428DRAFT_5110	5.323e-35	138.0	COG2165@1|root,COG2165@2|Bacteria,46W6A@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD1_k127_3227655_29	497964.CfE428DRAFT_5108	2.337e-30	127.0	2BNE4@1|root,2ZUA2@2|Bacteria,46WGV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3227655_25	497964.CfE428DRAFT_5096	5.178e-40	160.0	COG3156@1|root,COG3156@2|Bacteria,46VZT@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Type II secretion system (T2SS), protein K	-	-	-	-	-	-	-	-	-	-	-	-	T2SSK
HKD1_k127_3227655_43	1163409.UUA_11533	3.097e-07	60.0	COG4795@1|root,COG4795@2|Bacteria,1MYPS@1224|Proteobacteria,1SHGQ@1236|Gammaproteobacteria,1X6ZS@135614|Xanthomonadales	135614|Xanthomonadales	U	General secretion pathway protein	xpsJ	-	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD1_k127_3227655_28	1125973.JNLC01000014_gene2478	4.605e-33	140.0	COG0500@1|root,COG2226@2|Bacteria,1N5QH@1224|Proteobacteria,2UM5M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
HKD1_k127_3227655_14	278963.ATWD01000001_gene4653	1.264e-113	376.0	COG0672@1|root,COG0672@2|Bacteria,3Y78C@57723|Acidobacteria,2JKXR@204432|Acidobacteriia	204432|Acidobacteriia	P	Iron permease FTR1 family	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD1_k127_3227655_1	204669.Acid345_2533	0.0	1038.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_3233947_0	583355.Caka_0128	1.369e-302	953.0	COG0587@1|root,COG0587@2|Bacteria,46S6W@74201|Verrucomicrobia,3K9E1@414999|Opitutae	414999|Opitutae	L	Belongs to the DNA polymerase type-C family. DnaE2 subfamily	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HKD1_k127_3271733_0	379066.GAU_3766	9.903e-66	231.0	COG3202@1|root,COG3202@2|Bacteria,1ZURB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	TLC ATP/ADP transporter	-	-	-	ko:K03301	-	-	-	-	ko00000	2.A.12	-	-	TLC
HKD1_k127_3271733_4	1382359.JIAL01000001_gene418	3.816e-22	102.0	COG0454@1|root,COG0456@2|Bacteria,3Y5G1@57723|Acidobacteria,2JJWU@204432|Acidobacteriia	204432|Acidobacteriia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_3271733_2	1121405.dsmv_1643	1.223e-46	171.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,42TWN@68525|delta/epsilon subdivisions,2WQDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD1_k127_3271733_3	1403819.BATR01000124_gene4368	4.787e-28	118.0	COG1917@1|root,COG1917@2|Bacteria,46Z3I@74201|Verrucomicrobia,2IW0C@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_3271733_1	1123073.KB899241_gene3395	2.943e-58	203.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3413089_6	497964.CfE428DRAFT_3229	2.751e-48	182.0	COG3685@1|root,COG3685@2|Bacteria,46VCV@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
HKD1_k127_3413089_1	1267535.KB906767_gene1580	2.317e-136	444.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	MA20_17390	-	-	ko:K00713,ko:K06338	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3413089_11	1112214.AHIS01000014_gene119	5.533e-11	64.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3413089_9	497964.CfE428DRAFT_6257	1.604e-24	108.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3413089_5	272134.KB731324_gene4403	9.417e-82	283.0	COG1295@1|root,COG1295@2|Bacteria,1G1HS@1117|Cyanobacteria,1H9BW@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Ribonuclease BN-like family	rbn	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_3413089_2	452637.Oter_4139	2.423e-134	436.0	COG1793@1|root,COG1793@2|Bacteria,46TP1@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM ATP dependent DNA ligase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD1_k127_3413089_4	1183438.GKIL_3693	1.916e-128	419.0	COG3569@1|root,COG3569@2|Bacteria,1G2R6@1117|Cyanobacteria	1117|Cyanobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD1_k127_3413089_12	68199.JNZO01000013_gene3966	7.917e-09	63.0	COG3427@1|root,COG3427@2|Bacteria,2I3CZ@201174|Actinobacteria	201174|Actinobacteria	E	oxidoreductase activity, acting on CH-OH group of donors	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3413089_7	1340493.JNIF01000003_gene3157	3.575e-40	154.0	COG1633@1|root,COG1633@2|Bacteria,3Y5HE@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HKD1_k127_3413089_8	204669.Acid345_2557	4.305e-39	152.0	2B7KW@1|root,320RZ@2|Bacteria,3Y7ZF@57723|Acidobacteria,2JN97@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3413089_3	251229.Chro_0549	1.545e-129	421.0	COG1028@1|root,COG1028@2|Bacteria,1G264@1117|Cyanobacteria,3VIYV@52604|Pleurocapsales	1117|Cyanobacteria	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_3413089_0	1396418.BATQ01000104_gene5478	5.35e-166	538.0	COG0467@1|root,COG0467@2|Bacteria,46S8R@74201|Verrucomicrobia,2IVV3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
HKD1_k127_3421141_8	1396141.BATP01000022_gene321	3.142e-70	240.0	COG2060@1|root,COG2060@2|Bacteria,46S9Y@74201|Verrucomicrobia,2ITVE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	-	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD1_k127_3421141_4	240016.ABIZ01000001_gene1718	9.435e-118	393.0	COG1055@1|root,COG1055@2|Bacteria,46S6A@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Putative citrate transport	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS_2
HKD1_k127_3421141_9	481448.Minf_0133	6.016e-66	240.0	COG2265@1|root,COG2265@2|Bacteria,46SYJ@74201|Verrucomicrobia,37H2T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	tRNA (Uracil-5-)-methyltransferase	trmA	-	2.1.1.190,2.1.1.35	ko:K03215,ko:K15331	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_3421141_12	497964.CfE428DRAFT_6193	3.975e-34	135.0	2FCQS@1|root,344TZ@2|Bacteria,46W38@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3421141_7	1183438.GKIL_3827	1.218e-87	300.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	alx	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD1_k127_3421141_1	497964.CfE428DRAFT_3635	3.51e-176	571.0	COG0782@1|root,COG1747@1|root,COG0782@2|Bacteria,COG1747@2|Bacteria,46S7F@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_3421141_6	497964.CfE428DRAFT_3657	5.005e-91	306.0	COG1385@1|root,COG1385@2|Bacteria,46SZQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD1_k127_3421141_5	204669.Acid345_1427	2.566e-101	338.0	COG0119@1|root,COG0119@2|Bacteria,3Y2NJ@57723|Acidobacteria,2JI67@204432|Acidobacteriia	204432|Acidobacteriia	E	HMGL-like	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_3421141_3	382464.ABSI01000010_gene3750	4.144e-143	463.0	COG0484@1|root,COG0484@2|Bacteria,46TKC@74201|Verrucomicrobia,2ITUR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_3421141_10	497964.CfE428DRAFT_3654	7.131e-47	175.0	COG0576@1|root,COG0576@2|Bacteria,46T79@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_3421141_2	497964.CfE428DRAFT_3653	2.514e-160	519.0	COG2208@1|root,COG2208@2|Bacteria,46SWK@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Sigma factor PP2C-like phosphatases	rsbU	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	GAF_2,PAS_3,SpoIIE
HKD1_k127_3421141_11	497964.CfE428DRAFT_3652	7.238e-47	175.0	COG1366@1|root,COG1366@2|Bacteria,46T4Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	rsbS	-	-	-	-	-	-	-	-	-	-	-	STAS
HKD1_k127_3421141_13	497964.CfE428DRAFT_3651	3.709e-32	134.0	2EMM1@1|root,33F9E@2|Bacteria,46TBT@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3421141_0	497964.CfE428DRAFT_3647	5e-324	1014.0	COG1236@1|root,COG1793@1|root,COG1236@2|Bacteria,COG1793@2|Bacteria,46SCR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA ligase N terminus	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K07577,ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,RMMBL
HKD1_k127_350042_0	247490.KSU1_B0100	1.53e-155	499.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4372
HKD1_k127_3536020_3	1537915.JU57_06865	3.781e-25	113.0	COG4238@1|root,COG4238@2|Bacteria,1N4E5@1224|Proteobacteria,42USX@68525|delta/epsilon subdivisions,2YQ09@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	major outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3536020_0	247490.KSU1_D0782	1.009e-130	435.0	COG3170@1|root,COG3170@2|Bacteria,2J3MN@203682|Planctomycetes	203682|Planctomycetes	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3536020_1	247490.KSU1_D0783	3.104e-82	286.0	COG0803@1|root,COG0803@2|Bacteria,2J0IP@203682|Planctomycetes	203682|Planctomycetes	P	Zinc-uptake complex component A periplasmic	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_3536020_2	1379698.RBG1_1C00001G0109	1.594e-74	260.0	COG1108@1|root,COG1108@2|Bacteria,2NQ6F@2323|unclassified Bacteria	2|Bacteria	U	ABC 3 transport family	znuB	-	-	ko:K02075,ko:K09816	ko02010,map02010	M00242,M00244	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD1_k127_3623140_1	497964.CfE428DRAFT_1884	6.551e-205	651.0	COG1109@1|root,COG1109@2|Bacteria,46SB1@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_3623140_5	1382359.JIAL01000001_gene597	8.991e-72	259.0	2EIHJ@1|root,33C8X@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3623140_4	525904.Tter_2752	8.303e-97	326.0	COG2423@1|root,COG2423@2|Bacteria,2NPI5@2323|unclassified Bacteria	2|Bacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,1.5.1.25,4.3.1.12	ko:K01750,ko:K18258,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000,ko04147	-	-	-	OCD_Mu_crystall
HKD1_k127_3623140_2	497964.CfE428DRAFT_3872	1.285e-150	486.0	COG0654@1|root,COG0654@2|Bacteria,46VIV@74201|Verrucomicrobia	74201|Verrucomicrobia	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD1_k127_3623140_3	1121930.AQXG01000001_gene1099	1.289e-112	372.0	COG1171@1|root,COG1171@2|Bacteria,4NEY2@976|Bacteroidetes,1IUV5@117747|Sphingobacteriia	976|Bacteroidetes	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3623140_0	497964.CfE428DRAFT_3549	1.763e-222	715.0	COG0438@1|root,COG0613@1|root,COG0438@2|Bacteria,COG0613@2|Bacteria,46SXZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3623140_6	497964.CfE428DRAFT_3551	5.237e-65	233.0	COG3233@1|root,COG3233@2|Bacteria,46VNN@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HKD1_k127_3623140_7	497964.CfE428DRAFT_0837	1.075e-47	178.0	COG2947@1|root,COG2947@2|Bacteria,46VWG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD1_k127_3623140_8	582899.Hden_1731	1.362e-18	88.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,3N708@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_3631192_2	1379270.AUXF01000001_gene2801	5.743e-38	144.0	COG0304@1|root,COG0304@2|Bacteria,1ZTE1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_3631192_1	1396141.BATP01000034_gene4146	1.344e-93	312.0	COG0336@1|root,COG0336@2|Bacteria,46SS0@74201|Verrucomicrobia,2ITZV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	tRNA (Guanine-1)-methyltransferase	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD1_k127_3631192_4	497964.CfE428DRAFT_2913	9.778e-21	94.0	COG1837@1|root,COG1837@2|Bacteria	2|Bacteria	L	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD1_k127_3631192_3	497964.CfE428DRAFT_2914	8.369e-30	121.0	COG0228@1|root,COG0228@2|Bacteria,46WC2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD1_k127_3631192_0	382464.ABSI01000021_gene429	5.882e-116	384.0	COG0541@1|root,COG0541@2|Bacteria,46SIU@74201|Verrucomicrobia,2ITP6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_3634690_2	1121015.N789_02375	8.495e-82	278.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria,1S6M1@1236|Gammaproteobacteria,1XAJC@135614|Xanthomonadales	135614|Xanthomonadales	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HKD1_k127_3634690_1	497964.CfE428DRAFT_0672	1.286e-134	440.0	COG1253@1|root,COG1253@2|Bacteria,46VJ6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CorC_HlyC,DUF21
HKD1_k127_3634690_3	497964.CfE428DRAFT_0673	4.613e-78	274.0	COG1253@1|root,COG1253@2|Bacteria,46W8Q@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function DUF21	-	-	-	-	-	-	-	-	-	-	-	-	DUF21
HKD1_k127_3634690_0	351607.Acel_1143	1.29e-232	734.0	COG3387@1|root,COG3387@2|Bacteria,2GJAD@201174|Actinobacteria,4ES2D@85013|Frankiales	201174|Actinobacteria	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD1_k127_3634690_4	448385.sce1010	5.368e-58	206.0	COG0454@1|root,COG0456@2|Bacteria,1RCYQ@1224|Proteobacteria,43BYG@68525|delta/epsilon subdivisions,2X3A9@28221|Deltaproteobacteria,2YV3A@29|Myxococcales	28221|Deltaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_3634690_8	390989.JOEG01000001_gene5094	3.26e-32	144.0	COG3055@1|root,COG4934@1|root,COG3055@2|Bacteria,COG4934@2|Bacteria,2IF2T@201174|Actinobacteria,4DBYG@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Kelch_1
HKD1_k127_3634690_6	1123508.JH636450_gene7219	2.35e-35	154.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3634690_7	871968.DESME_02010	2.298e-33	141.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	PATR
HKD1_k127_3662398_12	497964.CfE428DRAFT_6673	2.953e-34	135.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3662398_0	497964.CfE428DRAFT_0012	7.125e-146	473.0	COG0304@1|root,COG0304@2|Bacteria,46SKK@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_3662398_4	497964.CfE428DRAFT_0013	6.367e-84	291.0	COG0304@1|root,COG0304@2|Bacteria,46Z8H@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ketoacyl-synt
HKD1_k127_3662398_6	497964.CfE428DRAFT_2343	8.044e-65	229.0	COG1734@1|root,COG1734@2|Bacteria,46SVY@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Prokaryotic dksA/traR C4-type zinc finger	dksA	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD1_k127_3662398_13	1403819.BATR01000181_gene6224	1.245e-18	86.0	COG0267@1|root,COG0267@2|Bacteria,46T91@74201|Verrucomicrobia,2IUS7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Ribosomal protein L33	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD1_k127_3662398_11	497964.CfE428DRAFT_2341	7.694e-35	134.0	COG0238@1|root,COG0238@2|Bacteria,46TBC@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein S18	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD1_k127_3662398_7	497964.CfE428DRAFT_2957	1.257e-50	181.0	COG2026@1|root,COG2026@2|Bacteria,46T5H@74201|Verrucomicrobia	74201|Verrucomicrobia	DJ	Addiction module toxin, RelE StbE family	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD1_k127_3662398_3	497964.CfE428DRAFT_4525	3.246e-97	331.0	COG0787@1|root,COG0787@2|Bacteria,46SM1@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD1_k127_3662398_9	497964.CfE428DRAFT_3689	3.818e-43	165.0	COG1214@1|root,COG1214@2|Bacteria,46T3K@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Glycoprotease family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M22
HKD1_k127_3662398_10	1403819.BATR01000002_gene22	4.054e-36	145.0	COG0802@1|root,COG0802@2|Bacteria,46T3C@74201|Verrucomicrobia,2IUJT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Threonylcarbamoyl adenosine biosynthesis protein TsaE	-	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD1_k127_3662398_5	497964.CfE428DRAFT_3691	2.212e-82	284.0	COG0611@1|root,COG0611@2|Bacteria,46SV7@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_3662398_15	570952.ATVH01000011_gene138	1.591e-06	59.0	COG1266@1|root,COG1266@2|Bacteria,1NF98@1224|Proteobacteria,2UHG6@28211|Alphaproteobacteria,2JUK0@204441|Rhodospirillales	204441|Rhodospirillales	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_3662398_2	497964.CfE428DRAFT_3693	6.253e-103	345.0	COG0616@1|root,COG0616@2|Bacteria,46SQ5@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	signal peptide peptidase SppA, 36K type	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD1_k127_3662398_8	1242864.D187_003184	8.305e-44	169.0	COG0457@1|root,COG0457@2|Bacteria	1242864.D187_003184|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3662398_1	686340.Metal_1658	1.587e-111	376.0	COG0457@1|root,COG0457@2|Bacteria,1R6ZR@1224|Proteobacteria,1RRKI@1236|Gammaproteobacteria,1XDM3@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4071)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
HKD1_k127_3662398_16	1195236.CTER_2106	1.796e-06	54.0	COG5492@1|root,COG5492@2|Bacteria,1VX4D@1239|Firmicutes,252B8@186801|Clostridia	186801|Clostridia	N	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,TIG
HKD1_k127_3664487_2	768671.ThimaDRAFT_0847	6.306e-13	71.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria	1224|Proteobacteria	T	SMART ATP-binding region, ATPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD1_k127_3664487_4	1122917.KB899663_gene2592	1.476e-05	52.0	COG0823@1|root,COG1404@1|root,COG0823@2|Bacteria,COG1404@2|Bacteria,1UI51@1239|Firmicutes,4HV4Q@91061|Bacilli,26RB1@186822|Paenibacillaceae	91061|Bacilli	U	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_3664487_1	580332.Slit_1558	2.126e-48	180.0	arCOG05203@1|root,31A0K@2|Bacteria,1RHZR@1224|Proteobacteria,2VX85@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3664487_0	1173027.Mic7113_3556	6.73e-182	578.0	COG2312@1|root,COG2312@2|Bacteria,1GA2Z@1117|Cyanobacteria,1HG9W@1150|Oscillatoriales	1117|Cyanobacteria	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	Erythro_esteras
HKD1_k127_3664487_3	237368.SCABRO_02452	5.988e-12	67.0	COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes	203682|Planctomycetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3671125_3	575540.Isop_1665	5.943e-09	63.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
HKD1_k127_3671125_2	1166018.FAES_5157	5.464e-27	127.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HKD1_k127_3671125_1	1116472.MGMO_20c00060	1.353e-54	194.0	2D8VC@1|root,32TS1@2|Bacteria,1MZWT@1224|Proteobacteria,1T747@1236|Gammaproteobacteria,1XGP9@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3671125_0	234267.Acid_7851	1.169e-134	454.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3726044_1	452637.Oter_3121	9.755e-48	174.0	COG3791@1|root,COG3791@2|Bacteria,46T3T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM glutathione-dependent formaldehyde-activating GFA	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_3726044_3	1123073.KB899243_gene600	1.616e-25	113.0	2EH9H@1|root,33B1D@2|Bacteria,1NV7J@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3726044_0	1267534.KB906759_gene1729	1.509e-113	373.0	COG1013@1|root,COG1013@2|Bacteria,3Y3NE@57723|Acidobacteria,2JIEM@204432|Acidobacteriia	2|Bacteria	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	porB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD1_k127_3726044_2	1267534.KB906759_gene1728	3.36e-40	151.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,3Y3NX@57723|Acidobacteria,2JKIA@204432|Acidobacteriia	2|Bacteria	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	porA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM1164	PFOR_II,POR,POR_N,Transketolase_C
HKD1_k127_391965_2	1123234.AUKI01000013_gene1697	1.604e-31	125.0	COG5483@1|root,COG5483@2|Bacteria,4NNWS@976|Bacteroidetes,1I1Z4@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_391965_0	1234364.AMSF01000055_gene1087	1.309e-233	729.0	COG1788@1|root,COG2057@1|root,COG1788@2|Bacteria,COG2057@2|Bacteria,1MVEI@1224|Proteobacteria,1RNXB@1236|Gammaproteobacteria,1X3W4@135614|Xanthomonadales	135614|Xanthomonadales	I	transferase	-	-	2.8.3.5	ko:K01027	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_391965_1	370438.PTH_2316	1.922e-116	389.0	COG2271@1|root,COG2271@2|Bacteria,1TS8X@1239|Firmicutes,24A85@186801|Clostridia,2646A@186807|Peptococcaceae	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_393111_0	497964.CfE428DRAFT_2596	2.02e-109	367.0	COG0402@1|root,COG0402@2|Bacteria,46TB5@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Amidohydrolase family	ssnA	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_393111_2	497964.CfE428DRAFT_2595	2.377e-50	187.0	COG2138@1|root,COG2138@2|Bacteria,46W9E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cobalamin (vitamin B12) biosynthesis CbiX protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_393111_4	525904.Tter_2363	1.87e-20	97.0	COG1956@1|root,COG1956@2|Bacteria,2NPKF@2323|unclassified Bacteria	2|Bacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	yebR	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
HKD1_k127_393111_1	497964.CfE428DRAFT_2594	6.326e-100	332.0	COG2138@1|root,COG2138@2|Bacteria,46SPE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	CbiX	-	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD1_k127_393111_3	478741.JAFS01000002_gene659	7.201e-35	135.0	COG0667@1|root,COG0667@2|Bacteria,46SYS@74201|Verrucomicrobia,37G4F@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_40334_17	497964.CfE428DRAFT_2061	3.206e-16	80.0	COG0138@1|root,COG0138@2|Bacteria,46S5H@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD1_k127_40334_10	497964.CfE428DRAFT_1756	3.391e-70	253.0	COG2207@1|root,COG2207@2|Bacteria,46T4M@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, arabinose operon control protein	araC	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD1_k127_40334_6	1095769.CAHF01000006_gene1886	8.328e-133	430.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2VP5Q@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_13	497964.CfE428DRAFT_4673	5.251e-38	147.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	GAF_2,HATPase_c_2,SpoIIE
HKD1_k127_40334_4	497964.CfE428DRAFT_5370	1.854e-162	517.0	COG2255@1|root,COG2255@2|Bacteria,46SDS@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD1_k127_40334_15	235909.GK1718	6.885e-26	113.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,4HHUM@91061|Bacilli,1WGKT@129337|Geobacillus	91061|Bacilli	Q	SAM-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_40334_20	268407.PWYN_17820	0.0006046	45.0	COG0500@1|root,COG2226@2|Bacteria,1V3HT@1239|Firmicutes,4HHUM@91061|Bacilli,26SSS@186822|Paenibacillaceae	91061|Bacilli	Q	(SAM)-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_40334_9	661478.OP10G_1995	9.297e-87	301.0	COG0683@1|root,COG0683@2|Bacteria	2|Bacteria	E	ABC-type branched-chain amino acid transport systems, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_40334_5	497964.CfE428DRAFT_1008	4.667e-133	436.0	COG1570@1|root,COG1570@2|Bacteria,46SCN@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD1_k127_40334_3	1396141.BATP01000046_gene1888	1.666e-194	634.0	COG0628@1|root,COG2203@1|root,COG0628@2|Bacteria,COG2203@2|Bacteria,46S5V@74201|Verrucomicrobia,2IVEK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_40334_2	452637.Oter_0622	9.165e-220	688.0	COG0160@1|root,COG0160@2|Bacteria,46TE8@74201|Verrucomicrobia,3KA3D@414999|Opitutae	2|Bacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	dgdA	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	APH,Aminotran_3,Peptidase_M23
HKD1_k127_40334_11	497964.CfE428DRAFT_0420	4.072e-55	196.0	2AY99@1|root,31QBJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_1	497964.CfE428DRAFT_1006	0.0	1108.0	COG0296@1|root,COG0296@2|Bacteria,46SH5@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_40334_19	215803.DB30_1791	0.0001239	53.0	2EMUN@1|root,33FGZ@2|Bacteria,1NYFS@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_18	1123248.KB893320_gene3890	3.409e-08	63.0	COG3595@1|root,COG3595@2|Bacteria,4NSAQ@976|Bacteroidetes,1ITBV@117747|Sphingobacteriia	976|Bacteroidetes	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HKD1_k127_40334_14	273121.WS1743	4.993e-27	119.0	COG4238@1|root,COG4238@2|Bacteria,1N4E5@1224|Proteobacteria,42USX@68525|delta/epsilon subdivisions,2YQ09@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	M	major outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_12	1121472.AQWN01000004_gene775	1.779e-54	201.0	COG1994@1|root,COG1994@2|Bacteria,1TSA9@1239|Firmicutes,24CR6@186801|Clostridia,261RF@186807|Peptococcaceae	186801|Clostridia	S	PFAM Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_7	234267.Acid_7851	1.775e-130	440.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_8	234267.Acid_7851	2.106e-96	345.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_40334_0	497964.CfE428DRAFT_2741	0.0	1132.0	COG0556@1|root,COG0556@2|Bacteria,46SF2@74201|Verrucomicrobia	74201|Verrucomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_4039075_11	1038869.AXAN01000047_gene4503	9.995e-09	68.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,BNR_2,Big_3_2,CBM_35,DUF1080,F5_F8_type_C,PKD,RicinB_lectin_2,Trehalase
HKD1_k127_4039075_5	497964.CfE428DRAFT_4728	3.07e-64	228.0	COG0463@1|root,COG0463@2|Bacteria,46UW3@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_4039075_1	497964.CfE428DRAFT_4730	5.048e-154	490.0	COG0320@1|root,COG0320@2|Bacteria,46TZG@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD1_k127_4039075_4	497964.CfE428DRAFT_3446	2.768e-78	266.0	COG0353@1|root,COG0353@2|Bacteria,46SU3@74201|Verrucomicrobia	74201|Verrucomicrobia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim,Toprim_4
HKD1_k127_4039075_7	497964.CfE428DRAFT_3445	9.061e-48	187.0	COG2114@1|root,COG2114@2|Bacteria,46VIM@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4039075_0	240016.ABIZ01000001_gene4007	6.48e-169	546.0	COG1219@1|root,COG1219@2|Bacteria,46U7E@74201|Verrucomicrobia,2IVDM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
HKD1_k127_4039075_3	497964.CfE428DRAFT_1651	1.42e-87	299.0	COG0515@1|root,COG0515@2|Bacteria,46TX9@74201|Verrucomicrobia	74201|Verrucomicrobia	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,RicinB_lectin_2
HKD1_k127_4039075_2	497964.CfE428DRAFT_0417	2.456e-103	344.0	COG0564@1|root,COG0564@2|Bacteria,46SQY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_4039075_8	555779.Dthio_PD0143	5.12e-40	153.0	2DPSP@1|root,33387@2|Bacteria	2|Bacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_4039075_9	323097.Nham_0849	4.119e-38	148.0	COG2030@1|root,COG2030@2|Bacteria,1RGUP@1224|Proteobacteria,2UAYB@28211|Alphaproteobacteria,3JU65@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	N-terminal half of MaoC dehydratase	MA20_26800	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD1_k127_4039075_6	497964.CfE428DRAFT_0698	1.012e-48	179.0	COG3558@1|root,COG3558@2|Bacteria,46T07@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD1_k127_4039075_10	497964.CfE428DRAFT_6690	7.45e-31	123.0	COG2154@1|root,COG2154@2|Bacteria,46TB8@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Pterin 4 alpha carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD1_k127_4042262_0	497964.CfE428DRAFT_3471	5.802e-182	577.0	COG4122@1|root,COG4122@2|Bacteria,46TZ5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pup-ligase protein	-	-	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_4063501_27	497964.CfE428DRAFT_0829	1.598e-10	64.0	COG0644@1|root,COG0644@2|Bacteria	2|Bacteria	C	geranylgeranyl reductase activity	fixC	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	DAO,FAD_binding_3,Trp_halogenase
HKD1_k127_4063501_6	240016.ABIZ01000001_gene1548	6.903e-127	412.0	COG0190@1|root,COG0190@2|Bacteria,46TG7@74201|Verrucomicrobia,2ITSZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_4063501_17	478741.JAFS01000002_gene891	4.36e-43	167.0	COG2121@1|root,COG2121@2|Bacteria,46SZ0@74201|Verrucomicrobia,37GQD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD1_k127_4063501_11	497964.CfE428DRAFT_6143	4.887e-76	260.0	COG0163@1|root,COG0163@2|Bacteria,46V9E@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_4063501_13	1189612.A33Q_2852	9.081e-70	244.0	COG4947@1|root,COG4947@2|Bacteria,4PN8M@976|Bacteroidetes,47YGU@768503|Cytophagia	976|Bacteroidetes	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD1_k127_4063501_12	215803.DB30_3730	8.822e-76	264.0	COG2819@1|root,COG2819@2|Bacteria,1N4R1@1224|Proteobacteria,43BZF@68525|delta/epsilon subdivisions,2X7A6@28221|Deltaproteobacteria,2YXXF@29|Myxococcales	28221|Deltaproteobacteria	S	Putative esterase	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,Esterase
HKD1_k127_4063501_5	497964.CfE428DRAFT_0876	6.515e-132	428.0	COG0825@1|root,COG0825@2|Bacteria,46SE1@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD1_k127_4063501_15	497964.CfE428DRAFT_0877	1.574e-58	213.0	COG1376@1|root,COG1376@2|Bacteria,46W0P@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_4063501_18	497964.CfE428DRAFT_2239	4.246e-37	145.0	COG2322@1|root,COG2322@2|Bacteria,46SZT@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
HKD1_k127_4063501_2	497964.CfE428DRAFT_2960	1.596e-169	561.0	COG2982@1|root,COG2982@2|Bacteria,46SSM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	AsmA-like C-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2
HKD1_k127_4063501_8	429009.Adeg_1744	3.916e-84	290.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,42GGT@68295|Thermoanaerobacterales	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_4063501_22	399739.Pmen_4385	5.474e-28	118.0	COG3296@1|root,COG3296@2|Bacteria,1RET3@1224|Proteobacteria,1S4H0@1236|Gammaproteobacteria,1YGFD@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
HKD1_k127_4063501_0	497964.CfE428DRAFT_1506	8.706e-200	629.0	COG0766@1|root,COG0766@2|Bacteria,46S6Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_4063501_9	1396418.BATQ01000133_gene4052	1.278e-82	283.0	COG2890@1|root,COG2890@2|Bacteria,46SZE@74201|Verrucomicrobia,2IU5P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HKD1_k127_4063501_7	323848.Nmul_A0535	7.499e-116	388.0	COG3319@1|root,COG3319@2|Bacteria,1N402@1224|Proteobacteria,2W4G7@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4063501_1	247490.KSU1_C0781	2.017e-177	572.0	COG1404@1|root,COG1404@2|Bacteria	2|Bacteria	O	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_4063501_3	497964.CfE428DRAFT_1497	1.424e-147	475.0	COG0216@1|root,COG0216@2|Bacteria,46S6F@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_4063501_21	497964.CfE428DRAFT_1496	5.866e-31	122.0	COG0254@1|root,COG0254@2|Bacteria,46T4W@74201|Verrucomicrobia	74201|Verrucomicrobia	J	ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD1_k127_4063501_4	497964.CfE428DRAFT_1495	2.058e-141	465.0	COG0318@1|root,COG0318@2|Bacteria,46T7I@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_4063501_20	497964.CfE428DRAFT_1798	9.827e-32	137.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K02657,ko:K20972	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035,ko02044	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
HKD1_k127_4063501_14	314230.DSM3645_26499	5.963e-63	225.0	COG1011@1|root,COG1940@1|root,COG1011@2|Bacteria,COG1940@2|Bacteria,2J05I@203682|Planctomycetes	203682|Planctomycetes	GK	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD1_k127_4063501_10	240016.ABIZ01000001_gene5803	5.315e-77	265.0	COG1694@1|root,COG3956@2|Bacteria,46SNM@74201|Verrucomicrobia,2ITIM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	MazG nucleotide pyrophosphohydrolase domain	-	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
HKD1_k127_4063501_24	497964.CfE428DRAFT_3451	1.66e-21	101.0	COG1314@1|root,COG1314@2|Bacteria,46T75@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD1_k127_4063501_25	251221.35212318	9.281e-20	95.0	COG2062@1|root,COG2062@2|Bacteria,1G6QD@1117|Cyanobacteria	1117|Cyanobacteria	T	Phosphohistidine phosphatase, SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD1_k127_4063501_16	261292.Nit79A3_2506	6.195e-46	169.0	COG1940@1|root,COG1940@2|Bacteria,1NSQA@1224|Proteobacteria,2WC2A@28216|Betaproteobacteria,37479@32003|Nitrosomonadales	28216|Betaproteobacteria	GK	ROK family	-	-	2.7.1.63	ko:K00886	ko00010,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R02187,R02189	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_4090776_2	1396141.BATP01000059_gene2526	7.612e-114	376.0	COG0435@1|root,COG0435@2|Bacteria,46S81@74201|Verrucomicrobia,2IV4Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_2
HKD1_k127_4090776_1	877455.Metbo_1301	1.434e-150	489.0	arCOG02685@1|root,arCOG02685@2157|Archaea,2XV10@28890|Euryarchaeota	28890|Euryarchaeota	G	COG0477 Permeases of the major facilitator superfamily	csbC	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD1_k127_4090776_0	497964.CfE428DRAFT_0836	2.152e-283	889.0	COG3808@1|root,COG3808@2|Bacteria,46S7R@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD1_k127_4090776_3	1396141.BATP01000003_gene5111	8.344e-67	240.0	COG0745@1|root,COG1235@1|root,COG2203@1|root,COG0745@2|Bacteria,COG1235@2|Bacteria,COG2203@2|Bacteria,46UKB@74201|Verrucomicrobia,2IVU2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	KT	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2,Response_reg
HKD1_k127_4095324_2	926569.ANT_26630	9.383e-141	451.0	COG0667@1|root,COG0667@2|Bacteria,2G5VT@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_4095324_5	595460.RRSWK_07052	1.081e-33	139.0	COG0363@1|root,COG0363@2|Bacteria,2J0I5@203682|Planctomycetes	203682|Planctomycetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD1_k127_4095324_1	497964.CfE428DRAFT_6200	2.842e-154	492.0	COG1064@1|root,COG1064@2|Bacteria,46UVP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
HKD1_k127_4095324_3	756272.Plabr_2351	6.836e-78	265.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4095324_4	497964.CfE428DRAFT_0347	2.061e-36	144.0	2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4095324_0	497964.CfE428DRAFT_0348	5.931e-229	737.0	COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4108200_5	204669.Acid345_3656	3.797e-121	398.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD1_k127_4108200_12	1234364.AMSF01000061_gene2077	4.652e-20	96.0	2EUEA@1|root,33MWN@2|Bacteria,1NYM7@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4108200_4	1403819.BATR01000104_gene3614	5.049e-141	465.0	COG2812@1|root,COG2812@2|Bacteria,46SGC@74201|Verrucomicrobia,2ITGI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD1_k127_4108200_11	497964.CfE428DRAFT_1755	2.698e-31	127.0	COG0718@1|root,COG0718@2|Bacteria,46TA9@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD1_k127_4108200_1	349741.Amuc_2115	5.481e-161	518.0	COG0172@1|root,COG0172@2|Bacteria,46S70@74201|Verrucomicrobia,2ITV1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Seryl-tRNA synthetase N-terminal domain	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_4108200_6	497964.CfE428DRAFT_4099	9.161e-94	318.0	28JRZ@1|root,2Z9HI@2|Bacteria,46TRU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HKD1_k127_4108200_3	497964.CfE428DRAFT_2487	2.373e-148	485.0	28HQ3@1|root,2Z7XW@2|Bacteria,46U81@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF2851)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2851
HKD1_k127_4108200_0	497964.CfE428DRAFT_4667	5.443e-198	624.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,46S5K@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_4108200_9	497964.CfE428DRAFT_4666	1.71e-42	160.0	COG0054@1|root,COG0054@2|Bacteria,46T5S@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_4108200_10	497964.CfE428DRAFT_4665	6.939e-39	149.0	COG0781@1|root,COG0781@2|Bacteria,46T7V@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD1_k127_4108200_7	1396418.BATQ01000098_gene6002	2.244e-93	316.0	COG0552@1|root,COG0552@2|Bacteria,46SKC@74201|Verrucomicrobia,2ITIZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	U	SRP54-type protein, GTPase domain	-	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_4108200_2	497964.CfE428DRAFT_3452	4.119e-151	492.0	COG3104@1|root,COG3104@2|Bacteria,46VMC@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4108200_8	1265505.ATUG01000001_gene3622	5.69e-63	222.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,42N4Z@68525|delta/epsilon subdivisions,2WIKW@28221|Deltaproteobacteria,2MHKB@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD1_k127_4117101_23	497964.CfE428DRAFT_4864	1.373e-40	157.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117101_3	497964.CfE428DRAFT_1668	1.587e-137	452.0	COG0477@1|root,COG0477@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	entS	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_3
HKD1_k127_4117101_19	497964.CfE428DRAFT_1377	9.799e-52	199.0	2E6EE@1|root,3311V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117101_13	497964.CfE428DRAFT_1376	2.598e-78	274.0	2EF9S@1|root,3392N@2|Bacteria,46VYT@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117101_7	497964.CfE428DRAFT_5231	3.814e-127	413.0	COG1131@1|root,COG1131@2|Bacteria,46SF6@74201|Verrucomicrobia	74201|Verrucomicrobia	V	PFAM ABC transporter related	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4117101_8	497964.CfE428DRAFT_5232	4.963e-126	415.0	COG0842@1|root,COG0842@2|Bacteria,46SWI@74201|Verrucomicrobia	497964.CfE428DRAFT_5232|-	V	PFAM ABC-2 type transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117101_28	7994.ENSAMXP00000003683	3.184e-12	72.0	COG1028@1|root,KOG4170@1|root,KOG0725@2759|Eukaryota,KOG4170@2759|Eukaryota,38DZE@33154|Opisthokonta,3BA0D@33208|Metazoa,3CVGY@33213|Bilateria,480GA@7711|Chordata,49406@7742|Vertebrata,49ZAM@7898|Actinopterygii	33208|Metazoa	I	Hydroxysteroid dehydrogenase like 2	HSDL2	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005777,GO:0042579,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	SCP2,adh_short
HKD1_k127_4117101_27	338966.Ppro_0498	5.049e-13	80.0	2E6EE@1|root,3311V@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117101_25	1500894.JQNN01000001_gene528	3.444e-26	116.0	COG0671@1|root,COG0671@2|Bacteria,1PEF1@1224|Proteobacteria,2WAMH@28216|Betaproteobacteria,477R1@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_4117101_14	472759.Nhal_1235	1.184e-72	258.0	COG0392@1|root,COG0392@2|Bacteria,1RCBH@1224|Proteobacteria,1S366@1236|Gammaproteobacteria,1X1IF@135613|Chromatiales	135613|Chromatiales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD1_k127_4117101_9	1123368.AUIS01000019_gene1217	2.566e-101	335.0	COG2220@1|root,COG2220@2|Bacteria,1R5GU@1224|Proteobacteria,1SIPM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent hydrolases of the beta-lactamase fold	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD1_k127_4117101_17	204669.Acid345_0702	2.58e-62	221.0	COG0122@1|root,COG0122@2|Bacteria,3Y30W@57723|Acidobacteria,2JHWW@204432|Acidobacteriia	204432|Acidobacteriia	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_4117101_20	497964.CfE428DRAFT_2652	5.673e-48	184.0	COG2881@1|root,COG5523@1|root,COG2881@2|Bacteria,COG5523@2|Bacteria	2|Bacteria	T	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,DUF975,Yip1
HKD1_k127_4117101_5	497964.CfE428DRAFT_2473	7.215e-132	427.0	COG0451@1|root,COG0451@2|Bacteria,46SJG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_4117101_29	102129.Lepto7375DRAFT_3052	9.561e-09	66.0	COG0726@1|root,COG0726@2|Bacteria,1G6FJ@1117|Cyanobacteria,1HB8K@1150|Oscillatoriales	1117|Cyanobacteria	G	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_4117101_21	497964.CfE428DRAFT_2339	2.787e-43	166.0	COG0724@1|root,COG0724@2|Bacteria,46WD6@74201|Verrucomicrobia	74201|Verrucomicrobia	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_4117101_24	497964.CfE428DRAFT_2105	1.016e-38	154.0	COG3026@1|root,COG3026@2|Bacteria,46W95@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Outer membrane lipoprotein-sorting protein	-	-	-	-	-	-	-	-	-	-	-	-	LolA_like
HKD1_k127_4117101_22	497964.CfE428DRAFT_2104	7.415e-41	159.0	COG0671@1|root,COG0671@2|Bacteria,46W7N@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_4117101_6	497964.CfE428DRAFT_2103	6.348e-131	436.0	COG1807@1|root,COG1807@2|Bacteria,46SSE@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PMT_2,TPR_12
HKD1_k127_4117101_10	497964.CfE428DRAFT_2102	1.528e-92	309.0	COG0463@1|root,COG0463@2|Bacteria,46SPS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_4117101_16	497964.CfE428DRAFT_4578	8.923e-69	237.0	COG1762@1|root,COG1762@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	ptsN3	-	2.7.1.202	ko:K02768,ko:K02769,ko:K02770,ko:K02806	ko00051,ko01100,ko01120,ko02060,map00051,map01100,map01120,map02060	M00273	R03232	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.2.1	-	-	PTS_EIIA_2
HKD1_k127_4117101_1	349741.Amuc_2169	4.357e-203	649.0	COG0018@1|root,COG0018@2|Bacteria,46SH6@74201|Verrucomicrobia,2ITX2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Arginyl tRNA synthetase N terminal dom	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_4117101_0	497964.CfE428DRAFT_1955	0.0	1019.0	COG3280@1|root,COG3280@2|Bacteria,46SC6@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha amylase, catalytic domain	treY	-	5.4.99.15	ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R09995	-	ko00000,ko00001,ko00002,ko01000	-	GH13	-	Alpha-amylase
HKD1_k127_4117101_12	497964.CfE428DRAFT_3924	2.398e-84	283.0	COG0231@1|root,COG0231@2|Bacteria,46SQH@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD1_k127_4117101_4	497964.CfE428DRAFT_6327	1.661e-134	435.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,46S8G@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the SIS family. GutQ KpsF subfamily	gutQ	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD1_k127_4117101_11	497964.CfE428DRAFT_3746	9.472e-86	295.0	2F3W6@1|root,33WND@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117101_2	497964.CfE428DRAFT_3332	2.132e-174	567.0	COG0744@1|root,COG0744@2|Bacteria,46TMG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	Transgly,Transpeptidase
HKD1_k127_4142348_0	247490.KSU1_D0548	1.694e-160	513.0	COG0577@1|root,COG0577@2|Bacteria,2IWXH@203682|Planctomycetes	203682|Planctomycetes	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_4142348_1	247490.KSU1_D0549	4.574e-93	316.0	COG1136@1|root,COG1136@2|Bacteria,2IYS3@203682|Planctomycetes	203682|Planctomycetes	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4142348_3	247490.KSU1_D0550	3.616e-88	301.0	COG0845@1|root,COG0845@2|Bacteria,2IYUX@203682|Planctomycetes	203682|Planctomycetes	M	PFAM secretion protein HlyD	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_4142348_2	1396141.BATP01000056_gene3280	5.62e-92	313.0	COG1376@1|root,COG1376@2|Bacteria,46TD0@74201|Verrucomicrobia,2IU9W@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_4142348_7	237368.SCABRO_02165	7.237e-32	139.0	COG0589@1|root,COG0589@2|Bacteria,2J12B@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related	-	-	-	ko:K14055	-	-	-	-	ko00000	-	-	-	Usp
HKD1_k127_4142348_4	497964.CfE428DRAFT_3184	8.081e-84	286.0	COG1127@1|root,COG1127@2|Bacteria,46SRC@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_4142348_6	518766.Rmar_1007	2.733e-36	150.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FJR9@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4142348_5	118163.Ple7327_0398	1.843e-74	256.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,3VJI1@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_4142348_8	1479237.JMLY01000001_gene2639	4.7e-30	126.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_4211253_3	289376.THEYE_A0307	2.514e-06	57.0	COG1475@1|root,COG1475@2|Bacteria	2|Bacteria	K	chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	ParBc
HKD1_k127_4211253_2	452637.Oter_1936	4.083e-72	258.0	COG0582@1|root,COG0582@2|Bacteria,46TD6@74201|Verrucomicrobia,3K9G2@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_4211253_4	1380350.JIAP01000002_gene4747	0.0001919	44.0	COG2827@1|root,COG2827@2|Bacteria,1N04N@1224|Proteobacteria,2UCN4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	excinuclease ABC	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
HKD1_k127_4211253_0	1047013.AQSP01000075_gene1424	0.0	1225.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NQEH@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_4211253_1	497964.CfE428DRAFT_1973	3.637e-153	495.0	COG1488@1|root,COG1488@2|Bacteria,46SAG@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD1_k127_4223412_22	711393.AYRX01000059_gene2332	4.512e-73	254.0	COG1526@1|root,COG1526@2|Bacteria,2GKWC@201174|Actinobacteria	201174|Actinobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD1_k127_4223412_28	497964.CfE428DRAFT_0298	1.419e-56	202.0	COG2258@1|root,COG2258@2|Bacteria,46VBP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4223412_33	497964.CfE428DRAFT_0299	9.645e-34	137.0	COG0746@1|root,COG0746@2|Bacteria,46T8C@74201|Verrucomicrobia	74201|Verrucomicrobia	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD1_k127_4223412_17	497964.CfE428DRAFT_1048	7.059e-87	296.0	COG3757@1|root,COG3757@2|Bacteria,46WSP@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
HKD1_k127_4223412_6	215803.DB30_2967	5.135e-151	486.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,42Y78@68525|delta/epsilon subdivisions,2X3CW@28221|Deltaproteobacteria,2YUS0@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
HKD1_k127_4223412_10	984262.SGRA_2970	8.309e-137	446.0	COG1960@1|root,COG1960@2|Bacteria,4NEKJ@976|Bacteroidetes,1INZ7@117747|Sphingobacteriia	976|Bacteroidetes	I	acyl-CoA dehydrogenase	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_4223412_5	497964.CfE428DRAFT_6587	1.464e-158	509.0	COG0183@1|root,COG0183@2|Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_4223412_36	634452.APA01_24950	0.0006472	48.0	COG0346@1|root,COG0346@2|Bacteria,1RH3J@1224|Proteobacteria,2U9J3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD1_k127_4223412_31	1496688.ER33_14645	6.979e-46	175.0	COG0154@1|root,COG0154@2|Bacteria,1GDVJ@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD1_k127_4223412_14	1496688.ER33_14645	7.773e-114	374.0	COG0154@1|root,COG0154@2|Bacteria,1GDVJ@1117|Cyanobacteria	1117|Cyanobacteria	J	Belongs to the amidase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD1_k127_4223412_3	1396418.BATQ01000123_gene4933	3.155e-198	627.0	COG1509@1|root,COG1509@2|Bacteria,46SVQ@74201|Verrucomicrobia,2ITNU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Lysine-2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,LAM_C,Radical_SAM
HKD1_k127_4223412_26	497964.CfE428DRAFT_4436	2.98e-62	221.0	COG2345@1|root,COG2345@2|Bacteria,46SX5@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
HKD1_k127_4223412_2	1396418.BATQ01000171_gene2965	7.117e-239	754.0	COG0366@1|root,COG0366@2|Bacteria,46S7A@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
HKD1_k127_4223412_25	497964.CfE428DRAFT_0164	1.335e-64	231.0	COG0811@1|root,COG0811@2|Bacteria,46SY0@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD1_k127_4223412_32	478741.JAFS01000001_gene1264	5.032e-35	138.0	COG0848@1|root,COG0848@2|Bacteria,46T1K@74201|Verrucomicrobia,37GK3@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD1_k127_4223412_7	497964.CfE428DRAFT_0166	5.581e-151	508.0	COG0457@1|root,COG1729@1|root,COG0457@2|Bacteria,COG1729@2|Bacteria,46UJD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TPR_8
HKD1_k127_4223412_35	1268622.AVS7_04721	0.0004742	44.0	COG4804@1|root,COG4804@2|Bacteria,1NBWK@1224|Proteobacteria,2VJU6@28216|Betaproteobacteria,4ACFC@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1016)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1016
HKD1_k127_4223412_15	452637.Oter_4136	3.463e-99	337.0	COG3391@1|root,COG3391@2|Bacteria,46WC1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lactonase, 7-bladed beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HKD1_k127_4223412_9	497964.CfE428DRAFT_0326	4.602e-145	467.0	COG0075@1|root,COG0075@2|Bacteria,46SCI@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_4223412_8	497964.CfE428DRAFT_0801	4.93e-147	473.0	COG4586@1|root,COG4586@2|Bacteria,46TXF@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4223412_21	1396418.BATQ01000171_gene2946	9.982e-75	261.0	COG0451@1|root,COG0703@1|root,COG0451@2|Bacteria,COG0703@2|Bacteria,46SWG@74201|Verrucomicrobia,2IUD4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,SKI
HKD1_k127_4223412_18	497964.CfE428DRAFT_5017	8.016e-87	293.0	COG1354@1|root,COG1354@2|Bacteria,46UBD@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	-	-	-	-	-	-	-	-	-	-	-	-	SMC_ScpA
HKD1_k127_4223412_13	497964.CfE428DRAFT_0653	1.326e-127	418.0	COG0772@1|root,COG0772@2|Bacteria,46SQT@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Belongs to the SEDS family	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD1_k127_4223412_30	497964.CfE428DRAFT_4702	4.141e-49	179.0	COG1451@1|root,COG1451@2|Bacteria	2|Bacteria	S	Protein of unknown function DUF45	CP_0175	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45,SprT-like
HKD1_k127_4223412_20	497964.CfE428DRAFT_3031	3.704e-79	273.0	COG1624@1|root,COG1624@2|Bacteria,46SSQ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
HKD1_k127_4223412_19	1123070.KB899255_gene1293	3.399e-83	285.0	COG0294@1|root,COG0294@2|Bacteria,46SSW@74201|Verrucomicrobia,2ITVR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_4223412_29	443143.GM18_2778	8.932e-52	189.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,42RIQ@68525|delta/epsilon subdivisions,2WNC7@28221|Deltaproteobacteria,43SKU@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_4223412_1	497964.CfE428DRAFT_4550	4.376e-263	829.0	COG0557@1|root,COG0557@2|Bacteria,46U8T@74201|Verrucomicrobia	74201|Verrucomicrobia	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD1_k127_4223412_12	497964.CfE428DRAFT_4918	4.705e-130	427.0	COG0369@1|root,COG0369@2|Bacteria,46SEE@74201|Verrucomicrobia	74201|Verrucomicrobia	P	oxidoreductase FAD NAD(P)-binding domain protein	-	-	1.8.1.2	ko:K00380	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_1,Flavodoxin_1,NAD_binding_1
HKD1_k127_4223412_24	497964.CfE428DRAFT_0259	1.162e-67	234.0	COG2151@1|root,COG2151@2|Bacteria,46SWX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pfam:DUF59	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD1_k127_4223412_27	497964.CfE428DRAFT_6470	9.081e-58	206.0	COG0359@1|root,COG0359@2|Bacteria,46SYE@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD1_k127_4223412_4	497964.CfE428DRAFT_6469	2.021e-175	563.0	COG0305@1|root,COG0305@2|Bacteria,46SKM@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD1_k127_4223412_0	452637.Oter_3805	6.573e-282	880.0	COG0021@1|root,COG0021@2|Bacteria,46SHW@74201|Verrucomicrobia,3K74F@414999|Opitutae	414999|Opitutae	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_4223412_23	497964.CfE428DRAFT_1998	3.665e-70	252.0	COG3597@1|root,COG3597@2|Bacteria	2|Bacteria	S	protein domain associated with	ycgC	-	-	ko:K03595,ko:K06883,ko:K06946	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	DUF697,MMR_HSR1
HKD1_k127_4223412_11	497964.CfE428DRAFT_0236	5.598e-131	432.0	COG0030@1|root,COG1443@1|root,COG0030@2|Bacteria,COG1443@2|Bacteria,46T1S@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	NUDIX,RrnaAD
HKD1_k127_4223412_16	497964.CfE428DRAFT_2592	2.19e-92	310.0	COG3786@1|root,COG3786@2|Bacteria,46STB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_4223412_34	1210884.HG799462_gene8121	5.389e-23	100.0	COG0477@1|root,COG2271@1|root,COG2271@2|Bacteria,COG2814@2|Bacteria,2IZBA@203682|Planctomycetes	203682|Planctomycetes	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4303825_7	497964.CfE428DRAFT_0870	1.238e-95	320.0	COG0253@1|root,COG0253@2|Bacteria,46SKV@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD1_k127_4303825_14	497964.CfE428DRAFT_4884	9.789e-63	226.0	29JAD@1|root,3067W@2|Bacteria,46VPD@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4303825_21	1190606.AJYG01000102_gene1226	9.351e-44	165.0	COG3247@1|root,COG3247@2|Bacteria,1RH69@1224|Proteobacteria,1SAIB@1236|Gammaproteobacteria,1Y0A9@135623|Vibrionales	135623|Vibrionales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_4303825_17	497964.CfE428DRAFT_1737	5.675e-50	187.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, LuxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4303825_11	768671.ThimaDRAFT_0847	1.571e-72	268.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1SA31@1236|Gammaproteobacteria	1224|Proteobacteria	T	SMART ATP-binding region, ATPase-like	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD1_k127_4303825_19	1396141.BATP01000019_gene1732	1.601e-47	181.0	COG1595@1|root,COG1595@2|Bacteria,46V3P@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD1_k127_4303825_10	1210884.HG799462_gene8934	1.335e-73	279.0	COG0515@1|root,COG2319@1|root,COG0515@2|Bacteria,COG2319@2|Bacteria,2IXDF@203682|Planctomycetes	2|Bacteria	KLT	Protein kinase domain	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,WD40
HKD1_k127_4303825_25	760192.Halhy_5103	0.000666	50.0	2ER00@1|root,33IJJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4303825_20	760192.Halhy_5102	2.917e-44	173.0	COG3011@1|root,COG3011@2|Bacteria,4NP4T@976|Bacteroidetes,1IXPR@117747|Sphingobacteriia	976|Bacteroidetes	S	HTTM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	VKG_Carbox
HKD1_k127_4303825_18	497964.CfE428DRAFT_4379	4.324e-48	179.0	COG1664@1|root,COG1664@2|Bacteria,46VS6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_4303825_16	497964.CfE428DRAFT_4380	2.203e-60	218.0	COG1664@1|root,COG1664@2|Bacteria,46WDW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_4303825_23	330214.NIDE3376	2.363e-22	101.0	2ETMV@1|root,33M5M@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD1_k127_4303825_8	497964.CfE428DRAFT_4748	2.557e-93	315.0	COG1208@1|root,COG1208@2|Bacteria,46V3X@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_4303825_0	497964.CfE428DRAFT_0257	2.904e-307	969.0	COG2844@1|root,COG2844@2|Bacteria,46SI6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD1_k127_4303825_13	497964.CfE428DRAFT_3538	1.686e-63	224.0	COG0503@1|root,COG0503@2|Bacteria,46SV8@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD1_k127_4303825_12	497964.CfE428DRAFT_4314	6.867e-71	248.0	COG4137@1|root,COG4137@2|Bacteria,46T0T@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cytochrome C assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD1_k127_4303825_9	497964.CfE428DRAFT_4315	1.773e-82	287.0	COG0373@1|root,COG0373@2|Bacteria,46SMQ@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,Shikimate_DH
HKD1_k127_4303825_15	497964.CfE428DRAFT_4316	1.227e-62	226.0	COG0181@1|root,COG0181@2|Bacteria,46SWD@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD1_k127_4303825_2	497964.CfE428DRAFT_0339	3.753e-213	672.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,46S9P@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the precorrin methyltransferase family	cysG	-	2.1.1.107,4.2.1.75	ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4,TP_methylase
HKD1_k127_4303825_22	497964.CfE428DRAFT_0345	2.731e-24	102.0	COG0828@1|root,COG0828@2|Bacteria,46WUR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal protein S21	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_S21
HKD1_k127_4303825_1	247490.KSU1_D0975	3.865e-246	786.0	COG0249@1|root,COG0249@2|Bacteria,2IXGV@203682|Planctomycetes	203682|Planctomycetes	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	GO:0003674,GO:0003676,GO:0003677,GO:0003684,GO:0003690,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008094,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0030983,GO:0032300,GO:0032991,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1990391	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD1_k127_4303825_6	926550.CLDAP_33840	2.792e-116	384.0	COG1313@1|root,COG1313@2|Bacteria,2G65I@200795|Chloroflexi	200795|Chloroflexi	C	Radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_4303825_4	497964.CfE428DRAFT_3476	4.565e-132	436.0	COG0457@1|root,COG0457@2|Bacteria,46TQ7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8
HKD1_k127_4303825_24	382464.ABSI01000010_gene3790	6.493e-05	48.0	COG0469@1|root,COG0469@2|Bacteria,46SBJ@74201|Verrucomicrobia,2ITNV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Pyruvate kinase, barrel domain	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_4303825_3	497964.CfE428DRAFT_4839	1.044e-155	494.0	COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_4313024_5	1267533.KB906733_gene3362	6.736e-08	56.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_4313024_0	1122604.JONR01000004_gene851	8.467e-130	441.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_4313024_2	1122603.ATVI01000005_gene3502	5.296e-82	296.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_4313024_4	1121875.KB907546_gene2685	1.319e-09	68.0	2E3AK@1|root,31XZF@2|Bacteria,4NRCU@976|Bacteroidetes,1I3MB@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4313024_1	382464.ABSI01000012_gene2201	2.072e-98	343.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
HKD1_k127_4313024_3	1122604.JONR01000004_gene851	5.162e-23	101.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_431877_2	497964.CfE428DRAFT_2962	6.162e-151	484.0	COG2957@1|root,COG2957@2|Bacteria,46SAM@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HKD1_k127_431877_3	497964.CfE428DRAFT_5652	6.77e-78	270.0	2A8AI@1|root,30XBY@2|Bacteria,46SPH@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_431877_0	1396141.BATP01000041_gene2218	5.568e-164	530.0	COG0019@1|root,COG0019@2|Bacteria,46SC5@74201|Verrucomicrobia,2ITWM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Pyridoxal-dependent decarboxylase, pyridoxal binding domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_431877_5	246197.MXAN_1016	1.213e-05	51.0	COG2863@1|root,COG2863@2|Bacteria,1RKUY@1224|Proteobacteria,43BWX@68525|delta/epsilon subdivisions,2X77P@28221|Deltaproteobacteria,2Z1IB@29|Myxococcales	28221|Deltaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_431877_1	671143.DAMO_0766	9.997e-159	514.0	COG0493@1|root,COG1143@1|root,COG0493@2|Bacteria,COG1143@2|Bacteria,2NNUW@2323|unclassified Bacteria	2|Bacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	pcmB	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6,1.97.1.9	ko:K03388,ko:K12527	ko00450,ko00680,ko01100,ko01120,ko01200,map00450,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R07229,R11928,R11931,R11943,R11944	RC00011,RC02420	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_20,FlpD,Pyr_redox_2,Pyr_redox_3
HKD1_k127_4328143_14	1223410.KN050846_gene2424	1.499e-34	135.0	COG2964@1|root,COG2964@2|Bacteria	2|Bacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_22,HisKA,PAS_3,PAS_6,PAS_9
HKD1_k127_4328143_11	1183438.GKIL_0413	1.594e-61	235.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD1_k127_4328143_12	671143.DAMO_2857	6.865e-54	217.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD1_k127_4328143_17	1123508.JH636447_gene7857	2.398e-27	130.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,2IZ0P@203682|Planctomycetes	203682|Planctomycetes	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,Laminin_G_3
HKD1_k127_4328143_8	192952.MM_3026	1.858e-81	299.0	COG3391@1|root,arCOG02562@2157|Archaea,2XVNE@28890|Euryarchaeota	28890|Euryarchaeota	S	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase
HKD1_k127_4328143_9	1298880.AUEV01000004_gene2001	1.487e-71	253.0	COG3391@1|root,COG3391@2|Bacteria,2GK45@201174|Actinobacteria	201174|Actinobacteria	M	40-residue YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_D1,Lactonase
HKD1_k127_4328143_13	502025.Hoch_1576	6.131e-53	195.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_4328143_3	1183438.GKIL_2770	3.936e-152	516.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,1G1EB@1117|Cyanobacteria	1117|Cyanobacteria	KLT	serine threonine protein kinase	-	-	2.7.1.37,2.7.11.1	ko:K00870,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase,TPR_11,TPR_16,TPR_8
HKD1_k127_4328143_1	468059.AUHA01000002_gene43	1.432e-207	663.0	COG3186@1|root,COG3186@2|Bacteria,4NEX5@976|Bacteroidetes,1IQDN@117747|Sphingobacteriia	976|Bacteroidetes	E	Biopterin-dependent aromatic amino acid hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HKD1_k127_4328143_21	502025.Hoch_3106	1.364e-15	91.0	COG1196@1|root,COG1196@2|Bacteria,1NDEE@1224|Proteobacteria,432MG@68525|delta/epsilon subdivisions,2WX8S@28221|Deltaproteobacteria,2Z20N@29|Myxococcales	28221|Deltaproteobacteria	D	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
HKD1_k127_4328143_20	288705.RSal33209_0464	9.833e-19	93.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,1WA3Q@1268|Micrococcaceae	201174|Actinobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4328143_6	1403819.BATR01000021_gene754	1.444e-95	324.0	COG1376@1|root,COG1376@2|Bacteria,46UGX@74201|Verrucomicrobia,2IV70@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_4328143_5	1301098.PKB_2297	3.831e-97	325.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,1RRP4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Methyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_4328143_0	644968.DFW101_2128	1.426e-224	713.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,42MKI@68525|delta/epsilon subdivisions,2WM5H@28221|Deltaproteobacteria,2MEEN@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Domain of unknown function (DUF3459)	treZ-2	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD1_k127_4328143_22	1288484.APCS01000080_gene2122	8.905e-10	65.0	COG1670@1|root,COG1670@2|Bacteria,1WKC5@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	COGs COG1670 Acetyltransferase including N-acetylase of ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_4328143_4	1192034.CAP_6066	7.485e-100	339.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_4328143_23	1123073.KB899243_gene504	8.147e-08	61.0	2AEZN@1|root,314XR@2|Bacteria,1NSHG@1224|Proteobacteria,1SMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4328143_2	497964.CfE428DRAFT_4128	1.769e-171	546.0	COG0045@1|root,COG0045@2|Bacteria,46TDG@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_4328143_19	237368.SCABRO_00846	8.984e-20	103.0	2CCSR@1|root,32RWC@2|Bacteria,2J1M5@203682|Planctomycetes	203682|Planctomycetes	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_4328143_10	1121904.ARBP01000011_gene1543	1.078e-65	243.0	COG1073@1|root,COG1073@2|Bacteria,4P9E8@976|Bacteroidetes,47R3G@768503|Cytophagia	976|Bacteroidetes	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,PDZ_2
HKD1_k127_4328143_16	497964.CfE428DRAFT_4129	1.327e-30	126.0	COG0346@1|root,COG0346@2|Bacteria,46T5V@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4328143_18	278957.ABEA03000094_gene4684	4.964e-23	102.0	COG0346@1|root,COG0346@2|Bacteria,46T5V@74201|Verrucomicrobia,3K8BB@414999|Opitutae	414999|Opitutae	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4328143_7	478741.JAFS01000001_gene1800	3.272e-90	301.0	COG0074@1|root,COG0074@2|Bacteria,46SET@74201|Verrucomicrobia,37G7Z@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD1_k127_4333277_1	497964.CfE428DRAFT_3303	3.998e-250	782.0	COG0504@1|root,COG0504@2|Bacteria,46S8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD1_k127_4333277_22	497964.CfE428DRAFT_3304	1.577e-83	287.0	COG1212@1|root,COG1212@2|Bacteria,46SS4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD1_k127_4333277_28	234267.Acid_7157	1.421e-50	185.0	COG0241@1|root,COG0241@2|Bacteria,3Y5QH@57723|Acidobacteria	57723|Acidobacteria	E	Polynucleotide kinase 3 phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD1_k127_4333277_17	1396418.BATQ01000015_gene4297	4.158e-96	326.0	COG2870@1|root,COG2870@2|Bacteria,46T1J@74201|Verrucomicrobia,2IVXQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	pfkB family carbohydrate kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
HKD1_k127_4333277_29	497964.CfE428DRAFT_6339	1.042e-49	187.0	2F4CA@1|root,342S4@2|Bacteria,46VXA@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4333277_27	497964.CfE428DRAFT_6338	7.5e-52	188.0	2FDFS@1|root,345HD@2|Bacteria,46W4Y@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4333277_12	497964.CfE428DRAFT_6337	3.323e-132	428.0	COG1702@1|root,COG1702@2|Bacteria,46S7S@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD1_k127_4333277_5	497964.CfE428DRAFT_6336	8.419e-201	640.0	COG1480@1|root,COG1480@2|Bacteria,46S4P@74201|Verrucomicrobia	74201|Verrucomicrobia	S	7TM receptor with intracellular HD hydrolase	-	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,HD
HKD1_k127_4333277_25	497964.CfE428DRAFT_3883	2.296e-69	240.0	COG0852@1|root,COG0852@2|Bacteria,46STM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD1_k127_4333277_20	497964.CfE428DRAFT_3884	1.237e-89	297.0	COG0377@1|root,COG0377@2|Bacteria,46SMM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_4333277_2	1260251.SPISAL_07325	1.692e-248	781.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MX0D@1224|Proteobacteria,1RNWT@1236|Gammaproteobacteria,1X2EG@135613|Chromatiales	135613|Chromatiales	P	PUA-like domain	-	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HKD1_k127_4333277_6	402777.KB235904_gene3348	2.093e-177	567.0	COG1012@1|root,COG1012@2|Bacteria,1G046@1117|Cyanobacteria,1H7Q6@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Aldehyde dehydrogenase	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	iECDH10B_1368.gabD,iJN678.gabD	Aldedh
HKD1_k127_4333277_9	661478.OP10G_1720	1.475e-162	528.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria	2|Bacteria	M	glycine betaine transport	yehZ	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
HKD1_k127_4333277_19	105559.Nwat_2548	5.087e-90	303.0	COG1125@1|root,COG1125@2|Bacteria,1QTUC@1224|Proteobacteria,1RQWQ@1236|Gammaproteobacteria,1WXWK@135613|Chromatiales	135613|Chromatiales	E	pfam abc	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran
HKD1_k127_4333277_18	316274.Haur_0996	5.196e-92	319.0	COG4301@1|root,COG4301@2|Bacteria,2G81E@200795|Chloroflexi	200795|Chloroflexi	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD1_k127_4333277_8	485913.Krac_7237	1.035e-162	524.0	COG1262@1|root,COG1262@2|Bacteria,2G89M@200795|Chloroflexi	200795|Chloroflexi	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HKD1_k127_4333277_36	497964.CfE428DRAFT_5369	2.544e-18	92.0	2C7SB@1|root,2ZTDJ@2|Bacteria,46WHI@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4333277_23	497964.CfE428DRAFT_6544	1.793e-83	287.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_4333277_14	497964.CfE428DRAFT_5385	1.302e-118	392.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Possible lysine decarboxylase	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_4333277_24	1116472.MGMO_138c00220	4.498e-80	281.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,1RXGH@1236|Gammaproteobacteria,1XG2N@135618|Methylococcales	135618|Methylococcales	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD1_k127_4333277_35	497964.CfE428DRAFT_5379	7.803e-28	119.0	COG0236@1|root,COG0236@2|Bacteria,46TAW@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD1_k127_4333277_38	497964.CfE428DRAFT_2589	5.271e-16	83.0	COG1826@1|root,COG1826@2|Bacteria,46WPX@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_4333277_21	1396418.BATQ01000119_gene3117	1.668e-86	295.0	COG1273@1|root,COG1273@2|Bacteria,46SB0@74201|Verrucomicrobia,2IVP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Ku70/Ku80 beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ku
HKD1_k127_4333277_34	1403819.BATR01000162_gene5349	1.345e-33	134.0	COG0199@1|root,COG0199@2|Bacteria,46TBH@74201|Verrucomicrobia,2IUM9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD1_k127_4333277_10	1403819.BATR01000162_gene5348	1.909e-145	474.0	COG1253@1|root,COG1253@2|Bacteria,46SMD@74201|Verrucomicrobia,2IU23@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_4333277_26	497964.CfE428DRAFT_0017	2.19e-58	206.0	COG1321@1|root,COG1321@2|Bacteria,46VZN@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
HKD1_k127_4333277_4	497964.CfE428DRAFT_0016	4.283e-230	719.0	COG1914@1|root,COG1914@2|Bacteria,46SH7@74201|Verrucomicrobia	74201|Verrucomicrobia	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD1_k127_4333277_31	861299.J421_4362	2.489e-42	162.0	COG0589@1|root,COG0589@2|Bacteria,1ZTUZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4333277_7	497964.CfE428DRAFT_0835	2.064e-174	556.0	COG0297@1|root,COG0297@2|Bacteria,46Z3D@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4333277_13	1396141.BATP01000017_gene2771	2.955e-122	402.0	COG0536@1|root,COG0536@2|Bacteria,46SBS@74201|Verrucomicrobia,2ITSD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD1_k127_4333277_11	497964.CfE428DRAFT_4498	1.904e-136	446.0	COG0438@1|root,COG0438@2|Bacteria,46TUX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4333277_16	497964.CfE428DRAFT_4495	1.596e-96	325.0	COG0356@1|root,COG0356@2|Bacteria,46SVZ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_4333277_37	497964.CfE428DRAFT_4494	5.008e-18	85.0	2DS8G@1|root,33EZT@2|Bacteria,46T9M@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATP synthase subunit C	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_4333277_30	497964.CfE428DRAFT_4493	3.197e-48	179.0	COG0711@1|root,COG0711@2|Bacteria,46SYI@74201|Verrucomicrobia	74201|Verrucomicrobia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_4333277_32	497964.CfE428DRAFT_4492	8.629e-39	149.0	COG0712@1|root,COG0712@2|Bacteria,46TC4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	ATP synthase delta (OSCP) subunit	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD1_k127_4333277_3	240016.ABIZ01000001_gene346	4.736e-246	767.0	COG0056@1|root,COG0056@2|Bacteria,46SB5@74201|Verrucomicrobia,2ITR0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD1_k127_4333277_15	497964.CfE428DRAFT_4490	7.983e-103	342.0	COG0224@1|root,COG0224@2|Bacteria,46SGU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD1_k127_4333277_0	497964.CfE428DRAFT_4489	1.886e-253	786.0	COG0055@1|root,COG0055@2|Bacteria,46SCC@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_4333277_33	497964.CfE428DRAFT_4487	2.938e-36	141.0	COG0355@1|root,COG0355@2|Bacteria,46T0F@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD1_k127_4481310_0	583355.Caka_2692	5.789e-280	873.0	COG0422@1|root,COG0422@2|Bacteria,46S5R@74201|Verrucomicrobia,3K77R@414999|Opitutae	414999|Opitutae	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD1_k127_4481310_5	497964.CfE428DRAFT_1387	3.522e-64	235.0	COG0860@1|root,COG0860@2|Bacteria,46SS7@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM cell wall hydrolase autolysin	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
HKD1_k127_4481310_7	935863.AWZR01000005_gene2289	6.848e-30	133.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,1RRI8@1236|Gammaproteobacteria,1X5HS@135614|Xanthomonadales	135614|Xanthomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD1_k127_4481310_1	452637.Oter_4614	1.237e-237	753.0	COG3590@1|root,COG3590@2|Bacteria,46UUX@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Peptidase family M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD1_k127_4481310_6	497964.CfE428DRAFT_0050	1.959e-43	166.0	COG3063@1|root,COG3063@2|Bacteria,46T56@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	PPR,TPR_11,TPR_2,TPR_8
HKD1_k127_4481310_8	1283284.AZUK01000001_gene2565	5.305e-11	75.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1Y3R6@135624|Aeromonadales	135624|Aeromonadales	O	Peptidylprolyl isomerase	ppiD	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,Rotamase_3,SurA_N_3
HKD1_k127_4481310_4	1382306.JNIM01000001_gene1966	3.536e-136	449.0	COG0076@1|root,COG0076@2|Bacteria,2G7N6@200795|Chloroflexi	200795|Chloroflexi	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28,4.1.2.27	ko:K01593,ko:K01634	ko00350,ko00360,ko00380,ko00600,ko00901,ko00950,ko00965,ko01100,ko01110,ko04071,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00600,map00901,map00950,map00965,map01100,map01110,map04071,map04726,map04728,map05030,map05031,map05034	M00037,M00042,M00100	R00685,R00699,R00736,R02080,R02464,R02701,R04909,R06516	RC00264,RC00299,RC00721,RC01266	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_4481310_3	497964.CfE428DRAFT_3837	2.116e-153	510.0	COG4775@1|root,COG4775@2|Bacteria,46TFS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HKD1_k127_4481310_2	497964.CfE428DRAFT_3838	6.797e-171	580.0	COG2911@1|root,COG2911@2|Bacteria,46TSK@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	-	-	-	-	-	-	-	-	-	TamB
HKD1_k127_4532235_4	497964.CfE428DRAFT_6073	2.028e-40	156.0	COG0860@1|root,COG0860@2|Bacteria,46SKJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	N-acetylmuramoyl-L-alanine amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD1_k127_4532235_0	497964.CfE428DRAFT_2305	1.974e-117	384.0	COG1692@1|root,COG1692@2|Bacteria,46SQ2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	YmdB-like protein	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HKD1_k127_4532235_6	1170562.Cal6303_0957	3.359e-06	57.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_8,Trypsin_2
HKD1_k127_4532235_3	497964.CfE428DRAFT_5294	3.181e-71	245.0	COG0290@1|root,COG0290@2|Bacteria,46SU6@74201|Verrucomicrobia	74201|Verrucomicrobia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD1_k127_4532235_2	452637.Oter_0107	3.208e-75	258.0	COG2761@1|root,COG2761@2|Bacteria	2|Bacteria	Q	protein disulfide oxidoreductase activity	frnE	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD1_k127_4532235_5	118168.MC7420_1391	2.137e-34	145.0	COG0705@1|root,COG0705@2|Bacteria,1G1Z3@1117|Cyanobacteria,1H857@1150|Oscillatoriales	1117|Cyanobacteria	S	(Rhomboid) family	-	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid
HKD1_k127_4532235_1	269799.Gmet_3159	2.382e-95	321.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_4575021_6	1123073.KB899245_gene90	2.993e-90	301.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,1X88E@135614|Xanthomonadales	135614|Xanthomonadales	E	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_4575021_8	316058.RPB_2776	1.326e-89	302.0	COG2520@1|root,COG2520@2|Bacteria,1N43N@1224|Proteobacteria,2UDB4@28211|Alphaproteobacteria,3JXB9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Methyltransferase fkbm family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4575021_11	240016.ABIZ01000001_gene1203	5.819e-37	144.0	COG1943@1|root,COG1943@2|Bacteria,46VNW@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_4575021_3	1183438.GKIL_3588	5.742e-177	568.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	pgcp	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD1_k127_4575021_14	338963.Pcar_3033	8.996e-07	57.0	2CA8B@1|root,33XH7@2|Bacteria,1NVUZ@1224|Proteobacteria,4300U@68525|delta/epsilon subdivisions,2WV6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4575021_10	1396418.BATQ01000091_gene5792	1.415e-43	164.0	2F83K@1|root,340H0@2|Bacteria,46VYE@74201|Verrucomicrobia,2IUSA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD1_k127_4575021_9	497964.CfE428DRAFT_2959	2.987e-80	274.0	2ED0A@1|root,336X9@2|Bacteria,46TCE@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4575021_0	240016.ABIZ01000001_gene2935	6.852e-248	778.0	COG0173@1|root,COG0173@2|Bacteria,46S7W@74201|Verrucomicrobia,2ITZA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_4575021_4	481448.Minf_0080	7.029e-135	441.0	COG0124@1|root,COG0124@2|Bacteria,46S7Y@74201|Verrucomicrobia,37G1T@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	Histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_4575021_2	497964.CfE428DRAFT_0163	1.815e-203	646.0	COG0322@1|root,COG0322@2|Bacteria,46SAJ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD1_k127_4575021_1	497964.CfE428DRAFT_4939	4.977e-239	756.0	COG0768@1|root,COG0768@2|Bacteria,46TSQ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Penicillin-binding Protein dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_4575021_7	478741.JAFS01000002_gene659	8.141e-90	302.0	COG0667@1|root,COG0667@2|Bacteria,46SYS@74201|Verrucomicrobia,37G4F@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_4608507_5	497964.CfE428DRAFT_2674	9.765e-37	145.0	COG0697@1|root,COG0697@2|Bacteria,46VGI@74201|Verrucomicrobia	74201|Verrucomicrobia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4608507_0	1403819.BATR01000008_gene271	0.0	1497.0	COG0458@1|root,COG0458@2|Bacteria,46SBT@74201|Verrucomicrobia,2IU2N@203494|Verrucomicrobiae	203494|Verrucomicrobiae	EF	Carbamoyl-phosphate synthetase large chain, oligomerisation domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_4608507_3	497964.CfE428DRAFT_1077	8.936e-61	213.0	COG2166@1|root,COG2166@2|Bacteria,46SRH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Fe-S metabolism associated domain	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
HKD1_k127_4608507_1	1396418.BATQ01000133_gene4037	4.118e-152	488.0	COG0039@1|root,COG0039@2|Bacteria,46SC4@74201|Verrucomicrobia,2ITGY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Catalyzes the reversible oxidation of malate to oxaloacetate	-	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_4608507_8	797114.C475_02071	5.102e-05	52.0	COG3794@1|root,arCOG02920@2157|Archaea,2XZQ0@28890|Euryarchaeota,23X32@183963|Halobacteria	183963|Halobacteria	C	Copper binding proteins, plastocyanin/azurin family	hcp1	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD1_k127_4608507_7	2045.KR76_07020	8.799e-12	69.0	COG0039@1|root,COG0039@2|Bacteria,2GJHS@201174|Actinobacteria,4DN1I@85009|Propionibacteriales	201174|Actinobacteria	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016020,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0030312,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_4608507_6	1123508.JH636450_gene7219	1.078e-31	135.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4608507_4	1449976.KALB_79	6.803e-57	208.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568,ko:K15257	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	Methyltransf_23,Methyltransf_31,Methyltransf_9
HKD1_k127_4608507_2	351348.Maqu_2638	2.798e-68	239.0	COG0500@1|root,COG0500@2|Bacteria,1QT89@1224|Proteobacteria,1SVTS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4823118_1	497964.CfE428DRAFT_4858	1.012e-24	106.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_4823118_0	765952.PUV_12850	0.0	2788.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	ndvB	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD1_k127_4908373_3	1267534.KB906754_gene2817	4.333e-130	427.0	COG2837@1|root,COG2837@2|Bacteria,3Y3R0@57723|Acidobacteria	57723|Acidobacteria	P	iron assimilation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4908373_2	1267534.KB906754_gene2818	1.855e-167	536.0	2DBCN@1|root,2Z8EJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4908373_1	1380354.JIAN01000005_gene1630	6.255e-198	623.0	COG0753@1|root,COG0753@2|Bacteria,2I4NI@201174|Actinobacteria	201174|Actinobacteria	P	catalase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4908373_5	1267533.KB906739_gene2479	5.475e-64	222.0	29FX8@1|root,302UX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4908373_0	1267534.KB906754_gene2823	9.622e-236	750.0	COG2010@1|root,COG2010@2|Bacteria,3Y31J@57723|Acidobacteria,2JKC9@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4908373_4	497964.CfE428DRAFT_5673	1.625e-86	295.0	COG2107@1|root,COG2107@2|Bacteria,46U2Z@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD1_k127_4918294_31	452637.Oter_1890	4.971e-35	138.0	COG0577@1|root,COG0577@2|Bacteria,46UZM@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_4	1183438.GKIL_4354	4.548e-168	557.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_45	1267534.KB906754_gene3787	6.558e-06	49.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_5	452637.Oter_1995	1.959e-163	542.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_3	452637.Oter_1883	1.849e-189	620.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_38	452637.Oter_1875	8.844e-16	82.0	COG0577@1|root,COG0577@2|Bacteria,46TJI@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_43	1267535.KB906767_gene5029	1.109e-06	56.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4918294_26	234267.Acid_2646	6.569e-53	196.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4918294_0	234267.Acid_2647	0.0	1300.0	COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria	57723|Acidobacteria	M	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_4918294_15	768671.ThimaDRAFT_0455	1.251e-89	310.0	COG0438@1|root,COG0438@2|Bacteria,1RF49@1224|Proteobacteria,1SHY6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD1_k127_4918294_30	313624.NSP_23120	4.191e-41	160.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_4918294_11	717785.HYPMC_3134	4.355e-100	341.0	COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2U1NW@28211|Alphaproteobacteria,3N8M7@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_4918294_40	933262.AXAM01000160_gene290	2.331e-13	74.0	2AFHA@1|root,315HT@2|Bacteria,1N31Y@1224|Proteobacteria,43DNR@68525|delta/epsilon subdivisions,2X6MU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_4918294_37	555779.Dthio_PD0754	9.532e-19	86.0	2AFHA@1|root,315HT@2|Bacteria,1N31Y@1224|Proteobacteria,43DNR@68525|delta/epsilon subdivisions,2X6MU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_4918294_20	314345.SPV1_00492	9.622e-75	254.0	COG0110@1|root,COG0110@2|Bacteria,1R6A3@1224|Proteobacteria	1224|Proteobacteria	S	acetyltransferase, isoleucine patch superfamily	wcaF	GO:0003674,GO:0003824,GO:0008374,GO:0016740,GO:0016746,GO:0016747	-	ko:K03818	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2
HKD1_k127_4918294_9	452637.Oter_2749	3.806e-110	363.0	COG0463@1|root,COG0463@2|Bacteria,46U7T@74201|Verrucomicrobia,3K8I1@414999|Opitutae	414999|Opitutae	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_4918294_34	1237149.C900_03640	5.813e-28	115.0	COG5470@1|root,COG5470@2|Bacteria,4NUEC@976|Bacteroidetes,47V9R@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD1_k127_4918294_10	497964.CfE428DRAFT_2439	9.406e-106	347.0	COG0613@1|root,COG0613@2|Bacteria,46UTR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PHP-associated	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD1_k127_4918294_7	401526.TcarDRAFT_0104	3.245e-129	436.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,4H20M@909932|Negativicutes	909932|Negativicutes	V	lipid A export permease ATP-binding protein MsbA	msbA	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HKD1_k127_4918294_25	497964.CfE428DRAFT_5305	6.11e-59	217.0	COG0859@1|root,COG0859@2|Bacteria,46VBS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_4918294_6	497964.CfE428DRAFT_1581	8.167e-141	461.0	COG0438@1|root,COG0438@2|Bacteria,46TF4@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HKD1_k127_4918294_12	497964.CfE428DRAFT_5304	1.3e-99	336.0	COG0438@1|root,COG0438@2|Bacteria,46W2P@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_4918294_33	497964.CfE428DRAFT_5327	7.288e-30	122.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS,STAS_2
HKD1_k127_4918294_18	497964.CfE428DRAFT_2435	7.371e-82	278.0	COG0546@1|root,COG0546@2|Bacteria,46SW1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,HAD_2
HKD1_k127_4918294_41	525904.Tter_1427	2.848e-13	78.0	COG1716@1|root,COG1716@2|Bacteria,2NQ4X@2323|unclassified Bacteria	2|Bacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
HKD1_k127_4918294_1	349741.Amuc_1036	3.244e-276	860.0	COG0481@1|root,COG0481@2|Bacteria,46SA7@74201|Verrucomicrobia,2IU2I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_4918294_13	497964.CfE428DRAFT_2117	2.909e-96	326.0	COG0681@1|root,COG0681@2|Bacteria,46SR0@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD1_k127_4918294_17	497964.CfE428DRAFT_2670	1.121e-83	289.0	COG1562@1|root,COG1562@2|Bacteria,46TVP@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	Amino_oxidase,SQS_PSY
HKD1_k127_4918294_44	1144312.PMI09_03588	1.522e-06	55.0	2EBP1@1|root,335P7@2|Bacteria,1NEQC@1224|Proteobacteria,2UF3H@28211|Alphaproteobacteria,4BG1E@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG
HKD1_k127_4918294_2	478741.JAFS01000002_gene189	5.293e-205	647.0	COG0043@1|root,COG0043@2|Bacteria,46TYE@74201|Verrucomicrobia,37G34@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	3-octaprenyl-4-hydroxybenzoate carboxy-lyase	ubiD	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_4918294_39	1396141.BATP01000026_gene1042	3.457e-14	78.0	2F8IJ@1|root,340XC@2|Bacteria,46WTZ@74201|Verrucomicrobia,2IUYP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4918294_42	1396141.BATP01000026_gene1042	2.711e-10	66.0	2F8IJ@1|root,340XC@2|Bacteria,46WTZ@74201|Verrucomicrobia,2IUYP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4918294_8	240016.ABIZ01000001_gene2263	1.042e-115	381.0	COG2896@1|root,COG2896@2|Bacteria,46V5U@74201|Verrucomicrobia,2IU2K@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Molybdenum Cofactor Synthesis C	-	-	-	-	-	-	-	-	-	-	-	-	Mob_synth_C,Radical_SAM
HKD1_k127_4918294_28	1403819.BATR01000103_gene3461	2.196e-44	167.0	COG0315@1|root,COG0315@2|Bacteria,46VUN@74201|Verrucomicrobia,2IUS5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	MoaC family	-	-	-	-	-	-	-	-	-	-	-	-	MoaC
HKD1_k127_4918294_22	1403819.BATR01000103_gene3462	3.641e-70	241.0	COG0521@1|root,COG0521@2|Bacteria,46SVJ@74201|Verrucomicrobia,2IUE2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Probable molybdopterin binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_4918294_14	240016.ABIZ01000001_gene1479	1.488e-92	315.0	COG0739@1|root,COG0739@2|Bacteria,46V20@74201|Verrucomicrobia,2IU1Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_4918294_35	497964.CfE428DRAFT_1899	4.601e-25	112.0	2DCGW@1|root,2ZE4S@2|Bacteria,46WFZ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Intracellular proteinase inhibitor	-	-	-	-	-	-	-	-	-	-	-	-	BsuPI
HKD1_k127_4918294_19	478741.JAFS01000002_gene923	3.713e-80	277.0	COG1387@1|root,COG1387@2|Bacteria,46YX1@74201|Verrucomicrobia,37GCT@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Histidinol phosphatase and related hydrolases of the PHP family	-	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_4918294_16	497964.CfE428DRAFT_3318	1.431e-87	298.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	yecE	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_4918294_24	497964.CfE428DRAFT_3832	1.017e-59	222.0	COG1729@1|root,COG4105@1|root,COG1729@2|Bacteria,COG4105@2|Bacteria,46SYU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	TPR_16,TPR_6,YfiO
HKD1_k127_4918294_29	497964.CfE428DRAFT_3831	1.594e-43	165.0	2EM72@1|root,33EW9@2|Bacteria,46TAB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
HKD1_k127_4918294_32	46234.ANA_C12350	9.997e-32	135.0	COG0457@1|root,COG0457@2|Bacteria,1G0N0@1117|Cyanobacteria,1HQK0@1161|Nostocales	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_12,TPR_7
HKD1_k127_4918294_21	497964.CfE428DRAFT_2296	1.578e-74	257.0	COG0500@1|root,COG2226@2|Bacteria,46STX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_4918294_27	497964.CfE428DRAFT_0731	3.453e-46	170.0	COG0811@1|root,COG0811@2|Bacteria,46SUA@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD1_k127_494723_3	338966.Ppro_1442	9.178e-82	276.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,42XB2@68525|delta/epsilon subdivisions,2WT59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_494723_0	373994.Riv7116_5866	1.148e-189	606.0	COG0477@1|root,COG0477@2|Bacteria,1GJ8D@1117|Cyanobacteria,1HSV0@1161|Nostocales	1117|Cyanobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_494723_1	204669.Acid345_0966	2.712e-95	321.0	COG0384@1|root,COG0384@2|Bacteria,3Y4H0@57723|Acidobacteria,2JJ47@204432|Acidobacteriia	204432|Acidobacteriia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_494723_2	1396858.Q666_12035	4.192e-82	278.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,1S2G7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_494723_4	1403819.BATR01000161_gene5267	1.695e-22	98.0	COG0492@1|root,COG0492@2|Bacteria,46UQK@74201|Verrucomicrobia,2IVE6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,cNMP_binding
HKD1_k127_505041_24	756272.Plabr_2232	2.142e-12	68.0	COG1030@1|root,COG1030@2|Bacteria,2IWTY@203682|Planctomycetes	203682|Planctomycetes	O	ClpP class	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
HKD1_k127_505041_27	391596.PBAL39_17904	0.0001461	47.0	COG2104@1|root,COG2104@2|Bacteria,4NX2F@976|Bacteroidetes	976|Bacteroidetes	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_505041_9	497964.CfE428DRAFT_1577	6.508e-154	495.0	COG0502@1|root,COG0502@2|Bacteria,46SFX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin and Thiamin Synthesis associated domain	-	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_505041_2	497964.CfE428DRAFT_3932	2.346e-257	801.0	COG1530@1|root,COG1530@2|Bacteria,46S5S@74201|Verrucomicrobia	74201|Verrucomicrobia	J	TIGRFAM ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G
HKD1_k127_505041_1	497964.CfE428DRAFT_3931	5.963e-274	863.0	COG0768@1|root,COG0768@2|Bacteria,46SE6@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM penicillin-binding protein transpeptidase	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Peptidase_M56,Transpeptidase
HKD1_k127_505041_19	497964.CfE428DRAFT_3930	8.149e-44	168.0	290WN@1|root,2ZNIF@2|Bacteria,46WW0@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_505041_15	497964.CfE428DRAFT_3929	5.124e-80	275.0	COG1792@1|root,COG1792@2|Bacteria,46T2J@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD1_k127_505041_6	1403819.BATR01000133_gene4729	1.402e-177	560.0	COG1077@1|root,COG1077@2|Bacteria,46SAA@74201|Verrucomicrobia,2ITYI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_505041_16	452637.Oter_4448	1.43e-72	251.0	COG0036@1|root,COG0036@2|Bacteria,46TEK@74201|Verrucomicrobia,3K7FI@414999|Opitutae	2|Bacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	GO:0003674,GO:0003824,GO:0004750,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006081,GO:0006098,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009052,GO:0009056,GO:0009117,GO:0009987,GO:0016052,GO:0016853,GO:0016854,GO:0016857,GO:0019321,GO:0019323,GO:0019362,GO:0019637,GO:0019682,GO:0019693,GO:0034641,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046365,GO:0046483,GO:0046496,GO:0046872,GO:0051156,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901135,GO:1901360,GO:1901564,GO:1901575	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_505041_3	497964.CfE428DRAFT_5092	8.698e-233	733.0	COG2804@1|root,COG2804@2|Bacteria,46TUR@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE,T2SSE_N
HKD1_k127_505041_26	1403819.BATR01000092_gene2748	1.386e-05	53.0	2E3AC@1|root,32Y9V@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_505041_7	497964.CfE428DRAFT_5085	6.311e-175	576.0	COG1450@1|root,COG1450@2|Bacteria,46UJ6@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Bacterial type II/III secretion system short domain	-	-	-	-	-	-	-	-	-	-	-	-	Secretin,Secretin_N
HKD1_k127_505041_20	1122604.JONR01000014_gene308	1.769e-34	140.0	COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,1SC2M@1236|Gammaproteobacteria,1X88I@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_505041_4	497964.CfE428DRAFT_4279	2.179e-204	645.0	COG0773@1|root,COG0773@2|Bacteria,46THM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Mur ligase middle domain protein	-	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_505041_11	1396418.BATQ01000073_gene506	3.406e-112	388.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,46V2N@74201|Verrucomicrobia,2IVVG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,Guanylate_cyc
HKD1_k127_505041_18	497964.CfE428DRAFT_4433	4.326e-47	173.0	COG0292@1|root,COG0292@2|Bacteria,46SZW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD1_k127_505041_10	497964.CfE428DRAFT_4430	7.033e-142	458.0	COG0016@1|root,COG0016@2|Bacteria,46S6R@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_505041_5	1396418.BATQ01000142_gene3288	4.159e-203	658.0	COG0072@1|root,COG0072@2|Bacteria,46SDG@74201|Verrucomicrobia,2ITHP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	B3/4 domain	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD1_k127_505041_8	1403819.BATR01000184_gene6355	2.553e-171	546.0	COG0505@1|root,COG0505@2|Bacteria,46TDX@74201|Verrucomicrobia,2ITTA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	F	Carbamoyl-phosphate synthase small chain, CPSase domain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_505041_21	481448.Minf_0191	2.763e-22	102.0	2CK2Q@1|root,329IJ@2|Bacteria,46ZCM@74201|Verrucomicrobia,37GU0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_505041_0	136993.KB900626_gene3898	0.0	1602.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,36X8N@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DEAD/H associated	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD1_k127_505041_17	1499967.BAYZ01000017_gene6259	4.826e-57	207.0	COG1215@1|root,COG1215@2|Bacteria,2NPW4@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_505041_12	485918.Cpin_1576	3.803e-112	373.0	COG1446@1|root,COG1446@2|Bacteria,4NF1U@976|Bacteroidetes,1IQI3@117747|Sphingobacteriia	976|Bacteroidetes	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HKD1_k127_505041_14	497964.CfE428DRAFT_3183	3.251e-88	299.0	COG0767@1|root,COG0767@2|Bacteria,46SY3@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_505041_13	497964.CfE428DRAFT_3184	3.977e-96	321.0	COG1127@1|root,COG1127@2|Bacteria,46SRC@74201|Verrucomicrobia	74201|Verrucomicrobia	Q	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_505041_25	608538.HTH_1768	4.44e-09	68.0	COG1463@1|root,COG1463@2|Bacteria,2G3I1@200783|Aquificae	200783|Aquificae	Q	Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_5063385_3	497964.CfE428DRAFT_5417	2.059e-74	259.0	COG0330@1|root,COG0330@2|Bacteria,46SQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_5063385_1	243233.MCA0313	1.727e-92	317.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RPUE@1236|Gammaproteobacteria,1XG0I@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could encode or regulate a protease	-	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_5063385_4	204669.Acid345_2815	5.417e-60	212.0	COG1225@1|root,COG1225@2|Bacteria,3Y4W0@57723|Acidobacteria,2JJ7A@204432|Acidobacteriia	204432|Acidobacteriia	O	Redoxin	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_5063385_2	1232410.KI421421_gene3792	3.082e-79	271.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,42WI7@68525|delta/epsilon subdivisions,2WSAF@28221|Deltaproteobacteria,43VM2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD1_k127_5063385_0	497964.CfE428DRAFT_3226	1.343e-164	528.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_5063385_5	497964.CfE428DRAFT_2313	1.754e-40	155.0	28HPC@1|root,2Z7XD@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HKD1_k127_5063385_7	1123242.JH636437_gene6098	1.123e-14	78.0	COG0861@1|root,COG0861@2|Bacteria	2|Bacteria	P	Integral membrane protein TerC family	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
HKD1_k127_5063385_6	1353531.AZNX01000012_gene3895	7.39e-16	78.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,2U8N1@28211|Alphaproteobacteria,4BFV9@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	NUDIX hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_5071979_2	497964.CfE428DRAFT_2150	3.967e-82	282.0	COG1235@1|root,COG1235@2|Bacteria,46VEV@74201|Verrucomicrobia	74201|Verrucomicrobia	S	May be involved in the transport of PQQ or its precursor to the periplasm	pqqB	-	-	ko:K06136	-	-	-	-	ko00000	-	-	-	Lactamase_B_2
HKD1_k127_5071979_1	497964.CfE428DRAFT_2149	9.379e-104	346.0	COG5424@1|root,COG5424@2|Bacteria,46TW4@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	pqqC	-	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	TENA_THI-4
HKD1_k127_5071979_3	1303518.CCALI_00347	2.026e-14	78.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqD	-	-	ko:K06138	-	-	-	-	ko00000	-	-	-	PqqD
HKD1_k127_5071979_0	497964.CfE428DRAFT_2147	1.488e-145	470.0	COG0535@1|root,COG0535@2|Bacteria,46T4P@74201|Verrucomicrobia	74201|Verrucomicrobia	C	SMART Elongator protein 3 MiaB NifB	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD1_k127_5077317_6	497964.CfE428DRAFT_1449	1.043e-05	51.0	COG4968@1|root,COG4968@2|Bacteria,46WJ1@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD1_k127_5077317_4	1403819.BATR01000010_gene397	1.213e-26	122.0	COG2885@1|root,COG2885@2|Bacteria,46T6J@74201|Verrucomicrobia,2IUNT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_5077317_1	497964.CfE428DRAFT_0875	1.819e-98	327.0	COG0413@1|root,COG0413@2|Bacteria,46SPN@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD1_k127_5077317_3	497964.CfE428DRAFT_0874	1.923e-45	169.0	COG0801@1|root,COG0801@2|Bacteria,46T2Z@74201|Verrucomicrobia	74201|Verrucomicrobia	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK)	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD1_k127_5077317_2	240016.ABIZ01000001_gene2099	2.738e-66	235.0	COG0289@1|root,COG0289@2|Bacteria,46SPR@74201|Verrucomicrobia,2IU1I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Dihydrodipicolinate reductase, N-terminus	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD1_k127_5077317_0	497964.CfE428DRAFT_0872	2.178e-108	358.0	COG0329@1|root,COG0329@2|Bacteria,46SDY@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_5077317_5	1396141.BATP01000007_gene5534	1.681e-09	59.0	COG0253@1|root,COG0253@2|Bacteria,46SKV@74201|Verrucomicrobia,2ITVJ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD1_k127_5091439_3	497964.CfE428DRAFT_2235	3.613e-93	313.0	COG1622@1|root,COG1622@2|Bacteria,46SPQ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase subunit II, periplasmic domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HKD1_k127_5091439_4	481448.Minf_1426	2.907e-69	251.0	COG1612@1|root,COG1612@2|Bacteria,46T3F@74201|Verrucomicrobia,37G83@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	Cytochrome oxidase assembly protein	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD1_k127_5091439_5	497964.CfE428DRAFT_2237	3.906e-66	236.0	COG0109@1|root,COG0109@2|Bacteria,46SQE@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD1_k127_5091439_6	497964.CfE428DRAFT_2238	4.567e-45	174.0	COG1999@1|root,COG1999@2|Bacteria,46VZB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_5091439_1	443143.GM18_2322	1.438e-110	366.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,42MTN@68525|delta/epsilon subdivisions,2WJAI@28221|Deltaproteobacteria,43S7Y@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rmlA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_5091439_0	1403819.BATR01000022_gene777	4.13e-123	421.0	COG0438@1|root,COG0438@2|Bacteria,46WZV@74201|Verrucomicrobia,2IW3I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_5091439_7	497964.CfE428DRAFT_4576	3.548e-36	140.0	2EMF0@1|root,33F3U@2|Bacteria,46TA3@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
HKD1_k127_5091439_2	203119.Cthe_3097	9.618e-107	357.0	COG1215@1|root,COG1215@2|Bacteria,1UI5W@1239|Firmicutes,25EJ5@186801|Clostridia,3WSJE@541000|Ruminococcaceae	186801|Clostridia	M	Family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HKD1_k127_5091439_8	859653.HIMB5_00012680	3.172e-27	121.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD1_k127_5117824_3	867900.Celly_1541	6.041e-33	131.0	COG4447@1|root,COG4447@2|Bacteria,4NESU@976|Bacteroidetes,1HXIG@117743|Flavobacteriia,1F7UI@104264|Cellulophaga	976|Bacteroidetes	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_5117824_2	479434.Sthe_2734	4.451e-33	135.0	COG5516@1|root,COG5516@2|Bacteria,2G7GV@200795|Chloroflexi	200795|Chloroflexi	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HKD1_k127_5117824_0	1163407.UU7_13758	9.249e-201	641.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Kelch_1,NPCBM,SpoIIE
HKD1_k127_5117824_1	28444.JODQ01000017_gene6582	1.531e-98	331.0	COG2256@1|root,COG2256@2|Bacteria,2GKDP@201174|Actinobacteria,4EFZJ@85012|Streptosporangiales	201174|Actinobacteria	L	MgsA AAA+ ATPase C terminal	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_5125552_1	933262.AXAM01000047_gene2343	2.92e-178	570.0	COG2252@1|root,COG2252@2|Bacteria,1MUV0@1224|Proteobacteria,42MAE@68525|delta/epsilon subdivisions,2WKFF@28221|Deltaproteobacteria,2MKCJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Permease family	pbuG	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD1_k127_5125552_4	686340.Metal_0729	1.681e-40	151.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,1SAWR@1236|Gammaproteobacteria,1XFGD@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HKD1_k127_5125552_2	497964.CfE428DRAFT_0924	1.16e-108	366.0	COG0795@1|root,COG0795@2|Bacteria,46STR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM permease YjgP YjgQ family protein	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD1_k127_5125552_0	243233.MCA0472	4.18e-219	697.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales	135618|Methylococcales	F	PFAM Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_5125552_3	1156937.MFUM_1010020	1.347e-83	297.0	COG1807@1|root,COG1807@2|Bacteria,46SSE@74201|Verrucomicrobia,37FZY@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PAP2,PMT_2,TPR_12
HKD1_k127_51294_0	1121472.AQWN01000002_gene2301	1.216e-291	917.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,2605R@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase III alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_51294_9	497964.CfE428DRAFT_5132	9.232e-53	188.0	COG0347@1|root,COG0347@2|Bacteria,46VXS@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Belongs to the P(II) protein family	-	-	-	-	-	-	-	-	-	-	-	-	P-II
HKD1_k127_51294_2	478741.JAFS01000001_gene1775	1.213e-221	695.0	COG0174@1|root,COG0174@2|Bacteria,46UCU@74201|Verrucomicrobia,37FVD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_51294_13	1396418.BATQ01000058_gene118	1.763e-21	100.0	COG0457@1|root,COG0457@2|Bacteria,46VSG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_51294_7	1403819.BATR01000114_gene3946	9.925e-66	233.0	COG0288@1|root,COG0288@2|Bacteria,46ST9@74201|Verrucomicrobia,2IWJF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Carbonic anhydrase	-	-	-	-	-	-	-	-	-	-	-	-	Pro_CA
HKD1_k127_51294_5	118166.JH976537_gene4259	8.19e-101	334.0	COG3217@1|root,COG3217@2|Bacteria,1G2HY@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain containing protein	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
HKD1_k127_51294_3	497964.CfE428DRAFT_0969	9.055e-204	644.0	COG0477@1|root,COG2814@2|Bacteria,46TKN@74201|Verrucomicrobia	74201|Verrucomicrobia	EGP	Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD1_k127_51294_10	497964.CfE428DRAFT_4353	3.438e-46	173.0	COG1514@1|root,COG1514@2|Bacteria,46SZP@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD1_k127_51294_6	211165.AJLN01000100_gene4217	3.964e-92	314.0	COG0300@1|root,COG0300@2|Bacteria,1G1AT@1117|Cyanobacteria,1JKU3@1189|Stigonemataceae	1117|Cyanobacteria	S	Fungal family of unknown function (DUF1776)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_51294_8	497964.CfE428DRAFT_6678	1.86e-57	205.0	COG0691@1|root,COG0691@2|Bacteria,46VGJ@74201|Verrucomicrobia	74201|Verrucomicrobia	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_51294_14	497964.CfE428DRAFT_6679	5.085e-21	96.0	COG1758@1|root,COG1758@2|Bacteria,46T94@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_51294_11	497964.CfE428DRAFT_3727	9.866e-26	113.0	2FH6M@1|root,34912@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4203
HKD1_k127_51294_15	107636.JQNK01000009_gene1767	2.143e-09	63.0	2DTI2@1|root,33KFK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_51294_4	1499498.EV05_0280	2.167e-154	497.0	COG1304@1|root,COG1304@2|Bacteria,1G32Y@1117|Cyanobacteria,1MM3B@1212|Prochloraceae	1117|Cyanobacteria	C	L-lactate dehydrogenase	lldD	-	1.1.2.3,1.1.3.46	ko:K00101,ko:K16422	ko00261,ko00620,ko01055,ko01100,ko01130,map00261,map00620,map01055,map01100,map01130	-	R00196,R06633	RC00044,RC00240	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD1_k127_51294_1	497964.CfE428DRAFT_2061	5.333e-226	708.0	COG0138@1|root,COG0138@2|Bacteria,46S5H@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD1_k127_5153630_8	497964.CfE428DRAFT_4057	5.889e-71	257.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_5153630_7	1192034.CAP_2776	2.102e-72	258.0	COG0438@1|root,COG0438@2|Bacteria,1N9EV@1224|Proteobacteria,42PK2@68525|delta/epsilon subdivisions,2WP9Y@28221|Deltaproteobacteria,2YW87@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_5153630_3	1123242.JH636437_gene6037	4.973e-120	400.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	GT87,PMT_2
HKD1_k127_5153630_9	666685.R2APBS1_1456	1.012e-43	176.0	COG2120@1|root,COG2120@2|Bacteria,1PGKP@1224|Proteobacteria,1RXHM@1236|Gammaproteobacteria,1X6FI@135614|Xanthomonadales	135614|Xanthomonadales	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_5153630_14	558173.CDOO_05730	2.409e-05	48.0	COG0477@1|root,COG2814@2|Bacteria,2GK1K@201174|Actinobacteria,22JJ8@1653|Corynebacteriaceae	201174|Actinobacteria	EGP	Major Facilitator	blt	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_5153630_11	272568.GDI0501	8.679e-31	136.0	COG0535@1|root,COG0535@2|Bacteria,1Q8U2@1224|Proteobacteria,2UYJA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_5153630_12	335543.Sfum_2923	2.042e-29	133.0	COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,43F1I@68525|delta/epsilon subdivisions,2WXQ5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD1_k127_5153630_6	452637.Oter_3937	3.931e-78	268.0	COG1136@1|root,COG1136@2|Bacteria,46UT0@74201|Verrucomicrobia,3K7YN@414999|Opitutae	414999|Opitutae	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD1_k127_5153630_5	794903.OPIT5_28845	4.561e-86	301.0	COG4591@1|root,COG4591@2|Bacteria,46UC8@74201|Verrucomicrobia,3K7GQ@414999|Opitutae	414999|Opitutae	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_5153630_13	1167006.UWK_03445	1.641e-14	86.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria,2MPVI@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_5153630_15	880073.Calab_2440	8.276e-05	55.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_5153630_10	452637.Oter_3801	4.621e-40	166.0	COG1538@1|root,COG1538@2|Bacteria,46T0P@74201|Verrucomicrobia,3K73I@414999|Opitutae	414999|Opitutae	MU	PFAM outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_5153630_2	1094980.Mpsy_2024	5.208e-169	538.0	COG1260@1|root,arCOG04213@2157|Archaea,2XVGK@28890|Euryarchaeota,2N96M@224756|Methanomicrobia	224756|Methanomicrobia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
HKD1_k127_5153630_0	497964.CfE428DRAFT_0920	1.175e-270	868.0	COG1074@1|root,COG1074@2|Bacteria	2|Bacteria	L	ATP-dependent DNA helicase activity	recB	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	AAA_19,DUF3799,NERD,PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_5153630_4	1123070.KB899259_gene1974	1.068e-101	351.0	COG3276@1|root,COG3276@2|Bacteria	2|Bacteria	J	selenocysteine insertion sequence binding	selB	GO:0000049,GO:0000166,GO:0001514,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006412,GO:0006414,GO:0006417,GO:0006451,GO:0006518,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009069,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016259,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019222,GO:0019538,GO:0019752,GO:0031323,GO:0031326,GO:0032268,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034248,GO:0034641,GO:0034645,GO:0035368,GO:0035639,GO:0036094,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051246,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:2000112	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD1_k127_5199937_2	1396418.BATQ01000158_gene2454	2.241e-174	551.0	COG0031@1|root,COG0031@2|Bacteria,46XBI@74201|Verrucomicrobia,2IVBD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Pyridoxal-phosphate dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	PALP
HKD1_k127_5199937_19	1392489.JPOL01000002_gene426	1.858e-06	54.0	COG2259@1|root,COG2259@2|Bacteria,4NSBJ@976|Bacteroidetes,1I2WV@117743|Flavobacteriia	976|Bacteroidetes	S	DoxX family	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_5199937_20	478741.JAFS01000001_gene2213	1.405e-05	51.0	COG2259@1|root,COG2259@2|Bacteria	2|Bacteria	S	methylamine metabolic process	ndh	-	1.6.99.3,1.8.5.2	ko:K03885,ko:K16937	ko00190,ko00920,ko01120,map00190,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxD,DoxX,Pyr_redox_2
HKD1_k127_5199937_6	886293.Sinac_4113	2.921e-113	377.0	COG4977@1|root,COG4977@2|Bacteria,2IXH9@203682|Planctomycetes	203682|Planctomycetes	K	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain	-	-	-	ko:K17736	-	-	-	-	ko00000,ko03000	-	-	-	DJ-1_PfpI,HTH_18
HKD1_k127_5199937_21	330779.Saci_0873	0.0004779	51.0	COG3350@1|root,arCOG04507@2157|Archaea,2XR9V@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HKD1_k127_5199937_12	450851.PHZ_c0831	1.737e-40	162.0	COG4977@1|root,COG4977@2|Bacteria,1PFG6@1224|Proteobacteria,2V7GC@28211|Alphaproteobacteria,2KJ6G@204458|Caulobacterales	204458|Caulobacterales	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD1_k127_5199937_17	1254432.SCE1572_04230	3.078e-13	78.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,SBP_bac_10,Thioredoxin
HKD1_k127_5199937_16	497964.CfE428DRAFT_3464	1.072e-22	108.0	COG4249@1|root,COG4249@2|Bacteria,46WW5@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_5199937_11	204669.Acid345_1452	1.036e-42	161.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5199937_18	909663.KI867150_gene972	1.608e-12	74.0	2CIE9@1|root,32S7U@2|Bacteria,1P112@1224|Proteobacteria,431TX@68525|delta/epsilon subdivisions,2WWP3@28221|Deltaproteobacteria,2MS3R@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4404)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4404
HKD1_k127_5199937_5	492774.JQMB01000007_gene4175	5.598e-132	443.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	1224|Proteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_2,TPR_8,Trans_reg_C
HKD1_k127_5199937_13	497964.CfE428DRAFT_0629	3.692e-39	150.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM,EthD
HKD1_k127_5199937_7	497964.CfE428DRAFT_0354	1.357e-95	322.0	COG3868@1|root,COG3868@2|Bacteria,46STS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Glycoside-hydrolase family GH114	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5199937_1	497964.CfE428DRAFT_0079	3.378e-209	662.0	COG0277@1|root,COG0277@2|Bacteria,46SFA@74201|Verrucomicrobia	74201|Verrucomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_5199937_15	1197906.CAJQ02000047_gene4077	1.822e-24	105.0	COG2329@1|root,COG2329@2|Bacteria,1N2ZS@1224|Proteobacteria,2UEPY@28211|Alphaproteobacteria,3K08M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5199937_9	478741.JAFS01000001_gene1899	1.054e-88	299.0	COG0623@1|root,COG0623@2|Bacteria,46UJB@74201|Verrucomicrobia,37G8S@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Enoyl-(Acyl carrier protein) reductase	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_5199937_0	661478.OP10G_1347	1.364e-252	809.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HKD1_k127_5199937_14	1396141.BATP01000025_gene896	3.652e-31	130.0	COG1158@1|root,COG1158@2|Bacteria,46S5Y@74201|Verrucomicrobia,2ITR1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HKD1_k127_5199937_4	1403819.BATR01000002_gene65	7.492e-149	484.0	COG1158@1|root,COG1158@2|Bacteria,46S5Y@74201|Verrucomicrobia,2ITR1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HKD1_k127_5199937_8	497964.CfE428DRAFT_4603	2.782e-93	321.0	COG0349@1|root,COG0349@2|Bacteria,46SUU@74201|Verrucomicrobia	74201|Verrucomicrobia	L	3'-5' exonuclease	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD1_k127_5199937_10	497964.CfE428DRAFT_3624	2.395e-45	173.0	COG1652@1|root,COG1652@2|Bacteria,46T8E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_5199937_3	497964.CfE428DRAFT_3353	1.282e-164	526.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD1_k127_5204263_9	382464.ABSI01000005_gene1099	3.023e-117	381.0	COG0396@1|root,COG0396@2|Bacteria,46SGE@74201|Verrucomicrobia,2ITY7@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	ATPases associated with a variety of cellular activities	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD1_k127_5204263_1	497964.CfE428DRAFT_3018	5.776e-268	828.0	COG0719@1|root,COG0719@2|Bacteria,46SGN@74201|Verrucomicrobia	74201|Verrucomicrobia	O	TIGRFAM FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_5204263_7	497964.CfE428DRAFT_3019	1.198e-155	502.0	COG0719@1|root,COG0719@2|Bacteria,46S8S@74201|Verrucomicrobia	74201|Verrucomicrobia	O	FeS assembly protein SufD	-	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_5204263_25	497964.CfE428DRAFT_5287	1.005e-39	151.0	COG0848@1|root,COG0848@2|Bacteria,46T4F@74201|Verrucomicrobia	74201|Verrucomicrobia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD1_k127_5204263_12	497964.CfE428DRAFT_5288	3.197e-102	338.0	COG0811@1|root,COG0811@2|Bacteria,46V4I@74201|Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD1_k127_5204263_13	240016.ABIZ01000001_gene4519	5.4e-102	344.0	COG0682@1|root,COG0682@2|Bacteria,46SSY@74201|Verrucomicrobia,2IU4I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_5204263_0	497964.CfE428DRAFT_4764	0.0	2427.0	COG0178@1|root,COG0178@2|Bacteria,46SAF@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_5204263_2	497964.CfE428DRAFT_6083	2.977e-264	825.0	COG1274@1|root,COG1274@2|Bacteria,46UB8@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD1_k127_5204263_26	478741.JAFS01000002_gene123	1.856e-37	152.0	COG0705@1|root,COG0705@2|Bacteria,46T69@74201|Verrucomicrobia,37GH0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_5204263_22	926566.Terro_1380	1.931e-60	214.0	COG0279@1|root,COG0279@2|Bacteria,3Y4UX@57723|Acidobacteria,2JJJ4@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD1_k127_5204263_20	497964.CfE428DRAFT_3416	4.506e-68	237.0	COG3963@1|root,COG3963@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,RrnaAD
HKD1_k127_5204263_5	240016.ABIZ01000001_gene3871	2.152e-199	634.0	COG0114@1|root,COG0114@2|Bacteria,46SFC@74201|Verrucomicrobia,2IVK5@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Fumarase C C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FumaraseC_C,Lyase_1
HKD1_k127_5204263_27	713586.KB900536_gene1302	1.001e-34	136.0	COG0346@1|root,COG0346@2|Bacteria,1REFQ@1224|Proteobacteria,1S3NT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5204263_15	497964.CfE428DRAFT_4823	3.033e-98	338.0	2EYYY@1|root,33S5Q@2|Bacteria,46UHA@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Fungal chitosanase of glycosyl hydrolase group 75	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_75
HKD1_k127_5204263_32	1173024.KI912148_gene4068	7.199e-10	64.0	COG5548@1|root,COG5548@2|Bacteria,1G997@1117|Cyanobacteria,1JIY6@1189|Stigonemataceae	1117|Cyanobacteria	S	Transmembrane proteins 14C	-	-	-	-	-	-	-	-	-	-	-	-	Tmemb_14
HKD1_k127_5204263_11	344747.PM8797T_00277	2.356e-104	352.0	COG1915@1|root,COG1915@2|Bacteria,2IWVZ@203682|Planctomycetes	203682|Planctomycetes	S	PFAM LOR SDH bifunctional	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HKD1_k127_5204263_16	575540.Isop_3073	4.67e-91	306.0	COG1834@1|root,COG1834@2|Bacteria,2IXSX@203682|Planctomycetes	203682|Planctomycetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD1_k127_5204263_4	497964.CfE428DRAFT_3156	2.093e-227	721.0	COG1387@1|root,COG1387@2|Bacteria,46TH0@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase X family	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD1_k127_5204263_29	313624.NSP_13770	1.159e-28	134.0	COG1404@1|root,COG2755@1|root,COG2834@1|root,COG1404@2|Bacteria,COG2755@2|Bacteria,COG2834@2|Bacteria,1GIN1@1117|Cyanobacteria,1HNE9@1161|Nostocales	1117|Cyanobacteria	MOQ	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,PPC,Peptidase_S8,SdrD_B
HKD1_k127_5204263_28	234267.Acid_7072	4.68e-34	151.0	2EJEC@1|root,33D5C@2|Bacteria,3Y8U5@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5204263_33	459349.CLOAM0520	5.551e-08	66.0	COG1404@1|root,COG4733@1|root,COG4932@1|root,COG1404@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria,2NREM@2323|unclassified Bacteria	2|Bacteria	O	Evidence 5 No homology to any previously reported sequences	J	-	-	ko:K14194,ko:K21449	ko05150,map05150	-	-	-	ko00000,ko00001,ko02000	1.B.40.2	-	-	DUF1983,DUF3672,Phage-tail_3,SdrD_B
HKD1_k127_5204263_24	497964.CfE428DRAFT_4983	2.809e-42	162.0	COG0741@1|root,COG0741@2|Bacteria,46W79@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transglycosylase SLT domain	mltE	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD1_k127_5204263_3	240016.ABIZ01000001_gene4727	3.933e-242	772.0	COG1198@1|root,COG1198@2|Bacteria,46U3N@74201|Verrucomicrobia,2ITWU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_5204263_21	682795.AciX8_0248	6.841e-65	231.0	COG3222@1|root,COG3222@2|Bacteria,3Y5T4@57723|Acidobacteria,2JKE7@204432|Acidobacteriia	204432|Acidobacteriia	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HKD1_k127_5204263_6	926566.Terro_3535	2.542e-173	550.0	COG0451@1|root,COG0451@2|Bacteria,3Y3CF@57723|Acidobacteria	57723|Acidobacteria	GM	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.25	ko:K17947	ko00523,ko01130,map00523,map01130	-	R10279	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD1_k127_5204263_14	497964.CfE428DRAFT_2026	3.418e-101	343.0	COG2239@1|root,COG2239@2|Bacteria	2|Bacteria	P	Acts as a magnesium transporter	mgtE1	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N,PRC
HKD1_k127_5204263_19	426117.M446_4901	4.755e-71	246.0	COG0463@1|root,COG0463@2|Bacteria,1RKJM@1224|Proteobacteria,2UANV@28211|Alphaproteobacteria,1JU6I@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5204263_18	414684.RC1_2019	1.113e-80	274.0	COG3751@1|root,COG3751@2|Bacteria,1R4BC@1224|Proteobacteria,2U2Q5@28211|Alphaproteobacteria,2JYT8@204441|Rhodospirillales	204441|Rhodospirillales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
HKD1_k127_5204263_23	671143.DAMO_1640	1.357e-58	218.0	COG0859@1|root,COG0859@2|Bacteria	2|Bacteria	M	ADP-heptose-lipopolysaccharide heptosyltransferase activity	-	-	-	ko:K02841,ko:K02843,ko:K02849,ko:K12982	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD1_k127_5204263_17	525904.Tter_0584	3.799e-87	307.0	COG2041@1|root,COG2041@2|Bacteria,2NQ7J@2323|unclassified Bacteria	2|Bacteria	S	Oxidoreductase molybdopterin binding domain	yedY	-	1.8.3.1	ko:K00387,ko:K07147	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00533	RC00168	ko00000,ko00001,ko01000	-	-	-	Mo-co_dimer,Oxidored_molyb
HKD1_k127_5204263_10	1382359.JIAL01000001_gene1052	3.982e-108	358.0	COG0492@1|root,COG0492@2|Bacteria,3Y2W6@57723|Acidobacteria,2JIIK@204432|Acidobacteriia	204432|Acidobacteriia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_5204263_8	497964.CfE428DRAFT_5119	1.855e-127	418.0	COG0438@1|root,COG0438@2|Bacteria,46U7I@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_5217626_11	706587.Desti_4248	4.274e-40	149.0	COG1063@1|root,COG1063@2|Bacteria,1MV9A@1224|Proteobacteria,42PCA@68525|delta/epsilon subdivisions,2WM39@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Catalyzes the NAD( )-dependent oxidation of L-threonine to 2-amino-3-ketobutyrate	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5217626_12	1501391.LG35_06475	2.457e-08	66.0	COG4122@1|root,COG4122@2|Bacteria,4NH42@976|Bacteroidetes,2FM5S@200643|Bacteroidia,22UDA@171550|Rikenellaceae	976|Bacteroidetes	S	O-methyltransferase	mdmC	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD1_k127_5217626_10	497964.CfE428DRAFT_5957	3.123e-48	182.0	COG3584@1|root,COG3584@2|Bacteria,46VUB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D
HKD1_k127_5217626_1	1313301.AUGC01000008_gene386	4.4e-180	571.0	COG0156@1|root,COG0156@2|Bacteria,4NFBU@976|Bacteroidetes	976|Bacteroidetes	E	Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA	kbl	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_5217626_0	497964.CfE428DRAFT_3346	1.137e-209	659.0	COG0520@1|root,COG0520@2|Bacteria,46S58@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_5217626_7	497964.CfE428DRAFT_3345	5.907e-70	239.0	COG0822@1|root,COG0822@2|Bacteria,46SZ3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM SUF system FeS assembly protein, NifU family	iscU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_5217626_9	1226994.AMZB01000121_gene3419	1.732e-57	207.0	COG1247@1|root,COG1247@2|Bacteria,1RDHN@1224|Proteobacteria,1SEM6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD1_k127_5217626_4	945713.IALB_1284	3.801e-119	396.0	COG2308@1|root,COG2308@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5217626_3	234267.Acid_3925	1.564e-126	413.0	COG2309@1|root,COG2309@2|Bacteria,3Y46T@57723|Acidobacteria	57723|Acidobacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M29
HKD1_k127_5217626_6	635013.TherJR_0948	1.983e-113	387.0	COG2132@1|root,COG2132@2|Bacteria,1TQSU@1239|Firmicutes,24CJP@186801|Clostridia,260KE@186807|Peptococcaceae	186801|Clostridia	Q	Multicopper oxidase	-	-	1.16.3.3	ko:K06324	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD1_k127_5217626_5	1173024.KI912153_gene217	5.729e-117	383.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,1JKMZ@1189|Stigonemataceae	1117|Cyanobacteria	F	Dihydroorotate dehydrogenase	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5217626_2	945713.IALB_1286	3.42e-147	475.0	COG2170@1|root,COG2170@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	ybdK	GO:0003674,GO:0003824,GO:0016874,GO:0016879	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD1_k127_5217626_8	278957.ABEA03000176_gene2841	8.185e-63	225.0	COG1999@1|root,COG1999@2|Bacteria,46W2T@74201|Verrucomicrobia,3K80B@414999|Opitutae	414999|Opitutae	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HKD1_k127_5225142_2	1123070.KB899256_gene2163	2.677e-92	314.0	COG0763@1|root,COG0763@2|Bacteria,46SSG@74201|Verrucomicrobia,2ITSK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD1_k127_5225142_1	497964.CfE428DRAFT_0881	1.421e-105	351.0	COG0673@1|root,COG0673@2|Bacteria,46SAE@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxidoreductase family, NAD-binding Rossmann fold	mviM	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_5225142_0	497964.CfE428DRAFT_4669	1.376e-139	450.0	COG0451@1|root,COG0451@2|Bacteria,46SD9@74201|Verrucomicrobia	74201|Verrucomicrobia	GM	Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction	fcl	-	1.1.1.271	ko:K02377	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R05692	RC01014	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD1_k127_5225142_3	756272.Plabr_3062	1.565e-09	68.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,SBP_bac_10
HKD1_k127_5244633_48	497964.CfE428DRAFT_0486	5.26e-11	64.0	COG0087@1|root,COG0087@2|Bacteria,46SQV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_5244633_34	497964.CfE428DRAFT_0485	1.159e-48	186.0	COG0051@1|root,COG0051@2|Bacteria,46SVV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD1_k127_5244633_0	497964.CfE428DRAFT_0484	0.0	1178.0	COG0480@1|root,COG0480@2|Bacteria,46SFV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_5244633_29	497964.CfE428DRAFT_0483	1.262e-67	233.0	COG0049@1|root,COG0049@2|Bacteria,46V3W@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD1_k127_5244633_28	497964.CfE428DRAFT_0482	2.596e-68	237.0	COG0048@1|root,COG0048@2|Bacteria,46SQR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD1_k127_5244633_5	497964.CfE428DRAFT_5931	6.559e-171	544.0	COG0343@1|root,COG0343@2|Bacteria,46TZR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_5244633_18	497964.CfE428DRAFT_1198	3.466e-99	329.0	COG0639@1|root,COG0639@2|Bacteria,46TA5@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Calcineurin-like phosphoesterase superfamily domain	apaH	-	-	-	-	-	-	-	-	-	-	-	Metallophos_2
HKD1_k127_5244633_26	497964.CfE428DRAFT_1199	6.289e-80	275.0	COG0457@1|root,COG0457@2|Bacteria,46VY0@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5244633_22	497964.CfE428DRAFT_1200	7.739e-88	299.0	COG1277@1|root,COG1277@2|Bacteria,46VKD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
HKD1_k127_5244633_14	497964.CfE428DRAFT_1201	3.087e-113	372.0	COG1131@1|root,COG1131@2|Bacteria,46SHV@74201|Verrucomicrobia	74201|Verrucomicrobia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5244633_43	497964.CfE428DRAFT_1202	1.546e-22	101.0	COG1254@1|root,COG1254@2|Bacteria,46W9W@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD1_k127_5244633_27	497964.CfE428DRAFT_0822	8.478e-71	248.0	2F4CA@1|root,342S4@2|Bacteria,46VXA@74201|Verrucomicrobia	497964.CfE428DRAFT_0822|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5244633_4	349741.Amuc_1184	1.596e-184	585.0	COG0148@1|root,COG0148@2|Bacteria,46S7N@74201|Verrucomicrobia,2ITUV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	-	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_5244633_8	240016.ABIZ01000001_gene923	9.277e-140	452.0	COG1186@1|root,COG1186@2|Bacteria,46SAW@74201|Verrucomicrobia,2ITHK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_5244633_35	497964.CfE428DRAFT_1903	3.625e-48	182.0	COG1104@1|root,COG1104@2|Bacteria,46TNH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_5244633_9	497964.CfE428DRAFT_1903	1.876e-134	438.0	COG1104@1|root,COG1104@2|Bacteria,46TNH@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_5244633_19	497964.CfE428DRAFT_1905	5.182e-98	332.0	COG1045@1|root,COG1045@2|Bacteria,46S5J@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_5244633_46	1123389.ATXJ01000004_gene1263	3.305e-17	87.0	2DUIA@1|root,32UXB@2|Bacteria,1WK6Z@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	SPW repeat	-	-	-	-	-	-	-	-	-	-	-	-	SPW
HKD1_k127_5244633_45	497964.CfE428DRAFT_1695	4.298e-19	98.0	COG1196@1|root,COG1196@2|Bacteria,46Z83@74201|Verrucomicrobia	74201|Verrucomicrobia	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5244633_37	497964.CfE428DRAFT_5968	3.104e-42	159.0	COG3688@1|root,COG3688@2|Bacteria,46T34@74201|Verrucomicrobia	74201|Verrucomicrobia	S	YacP-like NYN domain	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
HKD1_k127_5244633_11	497964.CfE428DRAFT_4703	2.141e-126	412.0	COG1044@1|root,COG1044@2|Bacteria,46SAD@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HKD1_k127_5244633_13	395495.Lcho_2075	3.072e-116	381.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,1KJZ0@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	enoyl-CoA hydratase	fadB3	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_5244633_20	497964.CfE428DRAFT_5497	1.406e-97	327.0	COG1192@1|root,COG1192@2|Bacteria,46SKQ@74201|Verrucomicrobia	74201|Verrucomicrobia	D	PFAM Cobyrinic acid ac-diamide synthase	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_5244633_42	99598.Cal7507_5865	3.124e-29	126.0	COG1670@1|root,COG1670@2|Bacteria,1GFNN@1117|Cyanobacteria,1HSNP@1161|Nostocales	1117|Cyanobacteria	J	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_5244633_24	404589.Anae109_2572	1.364e-80	275.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YZAW@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_5244633_30	497964.CfE428DRAFT_4693	6.122e-65	229.0	COG1211@1|root,COG1211@2|Bacteria,46T2A@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD1_k127_5244633_40	1242864.D187_008790	3.966e-30	124.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,42SH8@68525|delta/epsilon subdivisions,2WQ3S@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_5244633_36	1123073.KB899243_gene595	2.325e-44	175.0	COG2120@1|root,COG2120@2|Bacteria,1PGKP@1224|Proteobacteria,1RXHM@1236|Gammaproteobacteria,1X6FI@135614|Xanthomonadales	135614|Xanthomonadales	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_5244633_21	497964.CfE428DRAFT_2976	1.356e-93	330.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_5244633_16	497964.CfE428DRAFT_0542	4.307e-104	346.0	COG0331@1|root,COG0331@2|Bacteria,46SNS@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Acyl transferase domain	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD1_k127_5244633_3	497964.CfE428DRAFT_0519	4.028e-209	657.0	COG0649@1|root,COG0649@2|Bacteria,46SA0@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_5244633_50	748280.NH8B_2321	2.902e-05	50.0	COG2913@1|root,COG2913@2|Bacteria,1NMHT@1224|Proteobacteria,2VYJY@28216|Betaproteobacteria,2KTFJ@206351|Neisseriales	206351|Neisseriales	J	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5244633_2	1403819.BATR01000090_gene2641	1.778e-211	677.0	COG1894@1|root,COG1894@2|Bacteria,46S8J@74201|Verrucomicrobia,2ITYB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_5244633_41	46234.ANA_C20489	5.115e-30	123.0	COG0614@1|root,COG0614@2|Bacteria,1G79B@1117|Cyanobacteria,1HNFV@1161|Nostocales	1117|Cyanobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_5244633_1	497964.CfE428DRAFT_0528	1.022e-230	728.0	COG1034@1|root,COG3383@1|root,COG1034@2|Bacteria,COG3383@2|Bacteria,46S6S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HKD1_k127_5244633_10	497964.CfE428DRAFT_0529	2.325e-132	430.0	COG1005@1|root,COG1005@2|Bacteria,46SIJ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_5244633_23	497964.CfE428DRAFT_0530	1.392e-83	281.0	COG1143@1|root,COG1143@2|Bacteria,46SNT@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD1_k127_5244633_31	497964.CfE428DRAFT_0531	8.089e-53	191.0	COG0839@1|root,COG0839@2|Bacteria,46VSH@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_5244633_39	497964.CfE428DRAFT_0532	1.053e-34	143.0	COG0713@1|root,COG0713@2|Bacteria,46SX4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_5244633_7	497964.CfE428DRAFT_0535	1.367e-169	552.0	COG1009@1|root,COG1009@2|Bacteria,46SDU@74201|Verrucomicrobia	74201|Verrucomicrobia	CP	NADH Ubiquinone plastoquinone (complex I)	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_5244633_6	497964.CfE428DRAFT_0536	3.195e-170	552.0	COG1008@1|root,COG1008@2|Bacteria,46SE4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_5244633_15	1396141.BATP01000003_gene5069	3.925e-113	381.0	COG1007@1|root,COG1007@2|Bacteria,46ST5@74201|Verrucomicrobia,2IU1U@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_5244633_44	316274.Haur_4504	1.288e-20	109.0	COG5624@1|root,COG5624@2|Bacteria,2G94N@200795|Chloroflexi,377N8@32061|Chloroflexia	200795|Chloroflexi	K	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5244633_49	313606.M23134_08335	2.926e-06	61.0	COG4990@1|root,COG4990@2|Bacteria,4NPUN@976|Bacteroidetes	976|Bacteroidetes	S	G8	-	-	-	-	-	-	-	-	-	-	-	-	G8
HKD1_k127_5244633_33	1538295.JY96_16965	7.799e-49	201.0	COG2304@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG2304@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,1MU7T@1224|Proteobacteria,2WI67@28216|Betaproteobacteria,1KMDS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	MQU	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347
HKD1_k127_5244633_32	1123242.JH636435_gene2613	4.536e-50	187.0	COG1595@1|root,COG1595@2|Bacteria,2IZZP@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD1_k127_5244633_12	1379698.RBG1_1C00001G0607	1.404e-125	449.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_5244633_25	1122604.JONR01000031_gene1279	4.795e-80	304.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_5244633_17	497964.CfE428DRAFT_0539	9.786e-100	328.0	COG1403@1|root,COG1403@2|Bacteria,46SMP@74201|Verrucomicrobia	74201|Verrucomicrobia	L	HNH endonuclease	mcrA	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD1_k127_5244633_51	497964.CfE428DRAFT_4791	8.419e-05	48.0	COG0435@1|root,COG0435@2|Bacteria,46S81@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Glutathione S-transferase, N-terminal domain	-	-	1.8.5.7	ko:K07393	-	-	-	-	ko00000,ko01000	-	-	-	GST_C_2,GST_N_2
HKD1_k127_5248655_3	98439.AJLL01000035_gene2584	2.475e-43	160.0	COG0317@1|root,COG0317@2|Bacteria,1G0F8@1117|Cyanobacteria	1117|Cyanobacteria	KT	SMART metal-dependent phosphohydrolase, HD	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	HD_4
HKD1_k127_5248655_2	411477.PARMER_02289	3.049e-45	171.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,4NMAJ@976|Bacteroidetes,2FNTE@200643|Bacteroidia,22XGW@171551|Porphyromonadaceae	976|Bacteroidetes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD1_k127_5248655_1	215803.DB30_4561	3.214e-69	248.0	COG0451@1|root,COG0451@2|Bacteria,1RBSM@1224|Proteobacteria,42XUG@68525|delta/epsilon subdivisions,2WTSY@28221|Deltaproteobacteria,2YX8Q@29|Myxococcales	28221|Deltaproteobacteria	GM	NAD dependent epimerase/dehydratase family	-	-	1.3.1.45	ko:K05281	ko00943,ko01110,map00943,map01110	-	R06562,R06563,R07747,R07751	RC00805	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD1_k127_5248655_0	204669.Acid345_1624	2.028e-308	966.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria,2JIF7@204432|Acidobacteriia	204432|Acidobacteriia	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_5253094_3	452637.Oter_2585	4.097e-15	80.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_5253094_2	452637.Oter_2585	6.298e-16	81.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_5253094_0	452637.Oter_2584	6.883e-141	462.0	COG3005@1|root,COG3005@2|Bacteria	2|Bacteria	C	denitrification pathway	-	GO:0003674,GO:0003824,GO:0005575,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0031224,GO:0044237,GO:0044425,GO:0045333,GO:0055114	-	ko:K15876	ko00910,ko01120,map00910,map01120	M00530	R05712	RC00176	ko00000,ko00001,ko00002	-	-	-	Cytochrom_NNT,Cytochrom_c3_2
HKD1_k127_5253094_1	452637.Oter_2586	6.878e-36	150.0	2E533@1|root,32ZW9@2|Bacteria,46SZX@74201|Verrucomicrobia,3K856@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5291132_1	1396418.BATQ01000044_gene6460	8.235e-54	207.0	COG2304@1|root,COG2304@2|Bacteria,46Z4G@74201|Verrucomicrobia,2IVSP@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Nicotine adenine dinucleotide glycohydrolase (NADase)	-	-	-	-	-	-	-	-	-	-	-	-	NADase_NGA
HKD1_k127_5291132_0	240016.ABIZ01000001_gene4745	1.412e-95	335.0	COG2843@1|root,COG2843@2|Bacteria,46W53@74201|Verrucomicrobia,2IV2F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Bacterial capsule synthesis protein PGA_cap	-	-	-	-	-	-	-	-	-	-	-	-	PGA_cap
HKD1_k127_5298043_0	497964.CfE428DRAFT_4840	7.857e-235	737.0	COG0606@1|root,COG0606@2|Bacteria,46SAK@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM magnesium chelatase ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_5298043_1	497964.CfE428DRAFT_4839	3.105e-15	77.0	COG0568@1|root,COG0568@2|Bacteria,46SJ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_5311340_10	452637.Oter_4548	1.025e-47	174.0	COG1993@1|root,COG1993@2|Bacteria,46VZM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Uncharacterized ACR, COG1993	-	-	-	ko:K09137	-	-	-	-	ko00000	-	-	-	DUF190
HKD1_k127_5311340_12	663610.JQKO01000001_gene574	2.592e-39	150.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria,3NBPH@45404|Beijerinckiaceae	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD1_k127_5311340_4	497964.CfE428DRAFT_4255	1.491e-113	374.0	COG1137@1|root,COG1137@2|Bacteria,46SDI@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ABC transporter related	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
HKD1_k127_5311340_17	497964.CfE428DRAFT_4259	7.174e-17	89.0	2C4M2@1|root,2ZG2A@2|Bacteria,46WV2@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5311340_3	497964.CfE428DRAFT_4260	1.846e-123	400.0	COG2877@1|root,COG2877@2|Bacteria,46SMZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD1_k127_5311340_13	497964.CfE428DRAFT_2092	2.708e-36	148.0	COG5522@1|root,COG5522@2|Bacteria,46WTQ@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
HKD1_k127_5311340_15	1237149.C900_00956	1.646e-34	145.0	COG0589@1|root,COG0589@2|Bacteria,4NGG8@976|Bacteroidetes,47T99@768503|Cytophagia	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_5311340_8	497964.CfE428DRAFT_3893	1.677e-68	236.0	COG0669@1|root,COG0669@2|Bacteria,46SUT@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_5311340_14	497964.CfE428DRAFT_3892	4.891e-35	138.0	COG1399@1|root,COG1399@2|Bacteria,46TBP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	metal-binding, possibly nucleic acid-binding protein	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD1_k127_5311340_16	497964.CfE428DRAFT_3891	2.363e-21	94.0	COG0333@1|root,COG0333@2|Bacteria,46TCD@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Ribosomal L32p protein family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_5311340_5	481448.Minf_1215	3.552e-112	373.0	COG0416@1|root,COG0416@2|Bacteria,46S8C@74201|Verrucomicrobia,37G4Q@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD1_k127_5311340_1	497964.CfE428DRAFT_3889	2.33e-148	476.0	COG0332@1|root,COG0332@2|Bacteria,46SE2@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_5311340_9	485918.Cpin_5156	9.783e-58	208.0	COG4297@1|root,COG4297@2|Bacteria,4NNG0@976|Bacteroidetes,1ISDM@117747|Sphingobacteriia	976|Bacteroidetes	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
HKD1_k127_5311340_7	883078.HMPREF9695_02286	4.046e-91	307.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2TRRV@28211|Alphaproteobacteria,3JSI4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Phosphoenolpyruvate phosphomutase	MA20_35565	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD1_k127_5311340_0	497964.CfE428DRAFT_0737	1.317e-180	580.0	COG0265@1|root,COG0265@2|Bacteria,46UAN@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_5311340_2	497964.CfE428DRAFT_0736	1.638e-134	444.0	COG0265@1|root,COG0265@2|Bacteria,46SZ1@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
HKD1_k127_5311340_6	264198.Reut_A0613	2.78e-94	319.0	COG0598@1|root,COG0598@2|Bacteria,1MW8W@1224|Proteobacteria,2VH2A@28216|Betaproteobacteria,1K3VH@119060|Burkholderiaceae	28216|Betaproteobacteria	P	PFAM Mg2 transporter protein CorA family protein	-	-	-	ko:K16074	-	-	-	-	ko00000,ko02000	1.A.35.4	-	-	CorA
HKD1_k127_5311340_11	457429.ABJI02000446_gene5398	7.078e-46	169.0	COG0748@1|root,COG0748@2|Bacteria,2I5IZ@201174|Actinobacteria	201174|Actinobacteria	P	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD1_k127_5311340_19	913325.N799_02355	6.976e-08	58.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,1S7VF@1236|Gammaproteobacteria,1X54J@135614|Xanthomonadales	135614|Xanthomonadales	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB1	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_5337324_9	497964.CfE428DRAFT_3622	5.896e-46	170.0	COG1765@1|root,COG1765@2|Bacteria,46T1Y@74201|Verrucomicrobia	74201|Verrucomicrobia	O	PFAM OsmC family protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_5337324_2	28042.GU90_10355	9.444e-135	449.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4DXT1@85010|Pseudonocardiales	201174|Actinobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_5337324_14	388413.ALPR1_16109	1.176e-29	132.0	COG1566@1|root,COG1566@2|Bacteria,4NH7M@976|Bacteroidetes,47R1H@768503|Cytophagia	976|Bacteroidetes	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
HKD1_k127_5337324_4	497964.CfE428DRAFT_3140	1.159e-102	343.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641,ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.C.1.2	-	-	HYR,PD40
HKD1_k127_5337324_6	497964.CfE428DRAFT_3141	1.285e-82	288.0	COG4946@1|root,COG4946@2|Bacteria	2|Bacteria	M	serine-type peptidase activity	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	Amidohydro_1,PD40,PG_binding_1,Pkinase,TolB_N,WD40
HKD1_k127_5337324_0	497964.CfE428DRAFT_3135	0.0	1045.0	COG0013@1|root,COG0013@2|Bacteria,46SAY@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_5337324_1	497964.CfE428DRAFT_0030	5.344e-170	539.0	COG0468@1|root,COG0468@2|Bacteria,46SIZ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD1_k127_5337324_13	497964.CfE428DRAFT_3684	9.566e-36	139.0	COG0071@1|root,COG0071@2|Bacteria,46WRX@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_5337324_10	497964.CfE428DRAFT_3685	1.249e-44	169.0	COG0071@1|root,COG0071@2|Bacteria,46T3G@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Belongs to the small heat shock protein (HSP20) family	ibpA	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_5337324_15	886293.Sinac_3961	0.0005435	52.0	COG2013@1|root,COG2013@2|Bacteria	2|Bacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD1_k127_5337324_3	497964.CfE428DRAFT_4746	1.464e-110	364.0	COG0258@1|root,COG0258@2|Bacteria,46SWB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	5'-3' exonuclease	exo	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N
HKD1_k127_5337324_5	497964.CfE428DRAFT_4998	2.219e-91	312.0	COG0157@1|root,COG0157@2|Bacteria,46SPY@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the NadC ModD family	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_5337324_11	497964.CfE428DRAFT_4997	1.414e-43	167.0	COG0340@1|root,COG0340@2|Bacteria,46SX6@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_5337324_8	1396141.BATP01000059_gene2470	7.818e-51	181.0	COG1522@1|root,COG1522@2|Bacteria,46SDK@74201|Verrucomicrobia,2IU3G@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5379987_1	1267535.KB906767_gene1119	2.09e-88	299.0	293RY@1|root,2ZR7G@2|Bacteria,3Y953@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5379987_4	561229.Dd1591_2517	1.483e-24	108.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,2JERQ@204037|Dickeya	1236|Gammaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family protein	Z012_08285	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_5379987_5	547045.NEISICOT_01919	3.002e-21	106.0	2FACE@1|root,342KV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5379987_3	497964.CfE428DRAFT_1788	1.363e-66	236.0	COG1011@1|root,COG1011@2|Bacteria,46T57@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Haloacid dehalogenase-like hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD1_k127_5379987_2	335283.Neut_0487	1.026e-66	236.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,372CA@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD1_k127_5379987_0	497964.CfE428DRAFT_2106	4.893e-133	433.0	COG1522@1|root,COG1522@2|Bacteria,46SDK@74201|Verrucomicrobia	74201|Verrucomicrobia	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5388066_10	497964.CfE428DRAFT_6257	1.022e-18	90.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5388066_9	497964.CfE428DRAFT_3996	8.778e-23	98.0	COG3237@1|root,COG3237@2|Bacteria	2|Bacteria	K	CsbD-like	yjbJ	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	CsbD
HKD1_k127_5388066_12	1088869.GMO_11950	1.516e-12	68.0	2E4YG@1|root,32ZSB@2|Bacteria,1N74T@1224|Proteobacteria,2UGKQ@28211|Alphaproteobacteria,2JUN0@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3309
HKD1_k127_5388066_6	497964.CfE428DRAFT_3181	3.238e-37	147.0	COG1595@1|root,COG1595@2|Bacteria,46VRK@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_5388066_1	497964.CfE428DRAFT_4290	1.09e-188	600.0	COG0448@1|root,COG0448@2|Bacteria,46SG2@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the bacterial plant glucose-1-phosphate adenylyltransferase family	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_5388066_0	583355.Caka_2459	2.366e-209	668.0	COG0449@1|root,COG0449@2|Bacteria,46S94@74201|Verrucomicrobia,3K75B@414999|Opitutae	414999|Opitutae	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_5388066_4	700598.Niako_4073	3.883e-70	245.0	COG3945@1|root,COG3945@2|Bacteria,4NWY3@976|Bacteroidetes	976|Bacteroidetes	S	hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_5388066_5	1185652.USDA257_c02200	7.54e-47	175.0	COG1247@1|root,COG1247@2|Bacteria,1RDF5@1224|Proteobacteria,2U73C@28211|Alphaproteobacteria,4BDAB@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_4
HKD1_k127_5388066_13	1235797.C816_00211	1.349e-05	57.0	COG0265@1|root,COG0265@2|Bacteria,1UZ8K@1239|Firmicutes,24N2F@186801|Clostridia,2N6Z1@216572|Oscillospiraceae	186801|Clostridia	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF5050,RsgI_N,Trypsin_2
HKD1_k127_5388066_11	240016.ABIZ01000001_gene3464	3.139e-16	85.0	COG2259@1|root,COG2259@2|Bacteria,46WSE@74201|Verrucomicrobia,2IWGT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Methylamine utilisation protein MauE	-	-	-	-	-	-	-	-	-	-	-	-	MauE
HKD1_k127_5388066_8	278957.ABEA03000133_gene1595	8.212e-25	109.0	COG0607@1|root,COG0607@2|Bacteria,46WVZ@74201|Verrucomicrobia,3K8HQ@414999|Opitutae	414999|Opitutae	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_5388066_7	497964.CfE428DRAFT_0576	5.457e-30	127.0	COG2010@1|root,COG2010@2|Bacteria,46W2Y@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Protein of unknown function (DUF1573)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
HKD1_k127_5388066_3	497964.CfE428DRAFT_4453	5.677e-92	310.0	COG1091@1|root,COG1091@2|Bacteria,46T6F@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD1_k127_5388066_2	634956.Geoth_0303	1.713e-128	417.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,1WHF3@129337|Geobacillus	91061|Bacilli	M	Male sterility protein	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_5447190_19	710686.Mycsm_05230	1.635e-67	239.0	COG3103@1|root,COG3103@2|Bacteria,2IGZN@201174|Actinobacteria	201174|Actinobacteria	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_22	1123070.KB899264_gene1794	1.25e-59	213.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_75,Peptidase_S74,YadA_head
HKD1_k127_5447190_36	398720.MED217_08580	4.315e-12	72.0	2E2RH@1|root,32XTZ@2|Bacteria,4NTV2@976|Bacteroidetes,1I4NN@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_35	929556.Solca_3101	1.886e-12	72.0	2ER3W@1|root,33IPG@2|Bacteria,4NYM0@976|Bacteroidetes,1J030@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_18	765912.Thimo_1501	2.178e-68	258.0	COG1752@1|root,COG1752@2|Bacteria,1RBKJ@1224|Proteobacteria,1SN6B@1236|Gammaproteobacteria,1X0KP@135613|Chromatiales	135613|Chromatiales	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_21	247490.KSU1_D0551	1.209e-62	226.0	28MCN@1|root,2ZAQR@2|Bacteria,2J327@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_29	880073.Calab_1665	3.791e-36	150.0	COG0697@1|root,COG0697@2|Bacteria,2NPZZ@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	pagO	-	-	ko:K07790	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.7	-	-	EamA
HKD1_k127_5447190_17	497964.CfE428DRAFT_1374	1.665e-68	248.0	COG0582@1|root,COG0582@2|Bacteria	2|Bacteria	L	DNA integration	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD1_k127_5447190_24	518766.Rmar_2227	2.117e-58	210.0	COG2197@1|root,COG2197@2|Bacteria,4NP2G@976|Bacteroidetes,1FIR1@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_5447190_25	497964.CfE428DRAFT_5881	1.018e-54	205.0	COG4585@1|root,COG4585@2|Bacteria,46V1V@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD1_k127_5447190_32	1040989.AWZU01000016_gene2475	1.045e-21	99.0	COG3637@1|root,COG3659@1|root,COG3637@2|Bacteria,COG3659@2|Bacteria,1Q8C7@1224|Proteobacteria,2TU66@28211|Alphaproteobacteria,3JRBM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K16080	-	-	-	-	ko00000,ko02000	1.B.4.2.2	-	-	OMP_b-brl,OprB
HKD1_k127_5447190_38	876269.ARWA01000001_gene1802	1.179e-05	52.0	COG3637@1|root,COG3637@2|Bacteria,1MZ5U@1224|Proteobacteria,2TWHF@28211|Alphaproteobacteria,3NC7G@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K16079,ko:K16080	-	-	-	-	ko00000,ko02000	1.B.4.2.1,1.B.4.2.2	-	-	OMP_b-brl,OprB
HKD1_k127_5447190_40	1442599.JAAN01000026_gene1304	0.0005313	51.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,1S1E7@1236|Gammaproteobacteria,1X3DI@135614|Xanthomonadales	135614|Xanthomonadales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
HKD1_k127_5447190_12	497964.CfE428DRAFT_0418	9.1e-87	294.0	COG1573@1|root,COG1573@2|Bacteria,46SSB@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_5447190_14	1100721.ALKO01000003_gene2236	4.856e-80	279.0	COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,2VQQ2@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Squalene phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
HKD1_k127_5447190_11	497964.CfE428DRAFT_0842	5.912e-91	310.0	COG2006@1|root,COG2006@2|Bacteria,46T4A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_5447190_10	478741.JAFS01000002_gene821	4.458e-94	322.0	COG0635@1|root,COG0635@2|Bacteria,46STN@74201|Verrucomicrobia,37FV5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_5447190_4	497964.CfE428DRAFT_5681	1.98e-146	471.0	COG0836@1|root,COG0836@2|Bacteria,46SAQ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	manC	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD1_k127_5447190_31	621372.ACIH01000090_gene2944	2.727e-27	116.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,4HH04@91061|Bacilli,26XDH@186822|Paenibacillaceae	91061|Bacilli	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD1_k127_5447190_16	497964.CfE428DRAFT_5685	2.376e-73	254.0	COG0101@1|root,COG0101@2|Bacteria,46SSV@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD1_k127_5447190_37	1323663.AROI01000009_gene3658	1.799e-06	60.0	COG2909@1|root,COG2909@2|Bacteria,1MVZZ@1224|Proteobacteria,1RN29@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides. Binds and recognizes a DNA motif (called the malT box) 5'-GGA TG GA-3'	acoK	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_25,GerE,TPR_12
HKD1_k127_5447190_0	243231.GSU2782	0.0	1405.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_5447190_9	278957.ABEA03000197_gene423	4.659e-107	360.0	COG0845@1|root,COG0845@2|Bacteria,46U1B@74201|Verrucomicrobia,3K78A@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD1_k127_5447190_33	1411123.JQNH01000001_gene124	7.952e-21	100.0	COG1309@1|root,COG1309@2|Bacteria,1RARJ@1224|Proteobacteria,2UAVR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	BetI-type transcriptional repressor, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD1_k127_5447190_13	497964.CfE428DRAFT_2500	4.975e-83	286.0	COG0037@1|root,COG0037@2|Bacteria,46T0B@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS
HKD1_k127_5447190_3	497964.CfE428DRAFT_1797	1.301e-168	540.0	COG0008@1|root,COG0008@2|Bacteria,46SJ3@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_5447190_1	497964.CfE428DRAFT_5501	6.002e-261	822.0	COG0008@1|root,COG0008@2|Bacteria,46S4X@74201|Verrucomicrobia	74201|Verrucomicrobia	J	glutaminyl-tRNA synthetase	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD1_k127_5447190_15	497964.CfE428DRAFT_1796	1.736e-76	268.0	COG0169@1|root,COG0169@2|Bacteria,46SVF@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_5447190_8	497964.CfE428DRAFT_2215	7.19e-126	424.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Phosphodiest
HKD1_k127_5447190_2	478741.JAFS01000002_gene116	2.661e-197	629.0	COG1190@1|root,COG1190@2|Bacteria,46TIA@74201|Verrucomicrobia,37FUW@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	J	tRNA synthetases class II (D, K and N)	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_5447190_27	497964.CfE428DRAFT_0824	2.834e-40	155.0	COG4747@1|root,COG4747@2|Bacteria,46SXP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_30	497964.CfE428DRAFT_0076	1.272e-31	138.0	COG0457@1|root,COG0457@2|Bacteria,46TAX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_26	497964.CfE428DRAFT_0074	3.425e-51	197.0	2EV5U@1|root,33NKM@2|Bacteria,46WDA@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_28	1123070.KB899264_gene1811	1.371e-38	155.0	COG0860@1|root,COG0860@2|Bacteria,46VNJ@74201|Verrucomicrobia,2IUFY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD1_k127_5447190_5	497964.CfE428DRAFT_3694	4.477e-142	467.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,46S7Z@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD1_k127_5447190_6	1121957.ATVL01000011_gene3937	3.98e-133	438.0	COG0654@1|root,COG0654@2|Bacteria,4NGIU@976|Bacteroidetes,47KM9@768503|Cytophagia	976|Bacteroidetes	H	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid	kmo	-	1.14.13.9	ko:K00486	ko00380,ko01100,map00380,map01100	M00038	R01960	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD1_k127_5447190_20	497964.CfE428DRAFT_2418	2.627e-63	222.0	2DHFW@1|root,2ZZKM@2|Bacteria,46SNY@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	phyH	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5447190_7	324602.Caur_2349	3.34e-129	426.0	COG4638@1|root,COG4638@2|Bacteria,2G720@200795|Chloroflexi,377BT@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HKD1_k127_5595292_1	497964.CfE428DRAFT_1082	1.351e-251	787.0	COG1222@1|root,COG1222@2|Bacteria,46UBC@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Proteasomal ATPase OB/ID domain	-	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
HKD1_k127_5595292_5	1156937.MFUM_290019	3.175e-05	51.0	COG2220@1|root,COG2220@2|Bacteria,46ZEV@74201|Verrucomicrobia,37GY0@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD1_k127_5595292_2	1396418.BATQ01000047_gene6209	5.669e-204	649.0	COG2804@1|root,COG2804@2|Bacteria,46SDR@74201|Verrucomicrobia,2IU2P@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD1_k127_5595292_0	497964.CfE428DRAFT_1455	3.776e-262	817.0	COG2804@1|root,COG2804@2|Bacteria,46UFR@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD1_k127_5595292_3	497964.CfE428DRAFT_1451	1.104e-165	531.0	COG1459@1|root,COG1459@2|Bacteria,46S8P@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	type II secretion	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD1_k127_5595292_4	497964.CfE428DRAFT_1450	1.047e-31	132.0	COG2165@1|root,COG2165@2|Bacteria	2|Bacteria	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD1_k127_5615878_2	1122137.AQXF01000001_gene3162	3.834e-35	138.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,2TSE2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_5615878_0	452637.Oter_2821	6.444e-198	636.0	COG0755@1|root,COG0755@2|Bacteria,46SIH@74201|Verrucomicrobia,3K7UF@414999|Opitutae	414999|Opitutae	O	PFAM cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD1_k127_5615878_1	452637.Oter_2587	1.875e-102	342.0	COG1333@1|root,COG1333@2|Bacteria,46SUY@74201|Verrucomicrobia,3K75U@414999|Opitutae	414999|Opitutae	O	ResB-like family	-	-	-	-	-	-	-	-	-	-	-	-	ResB
HKD1_k127_5636099_0	1122134.KB893650_gene1319	3.948e-162	519.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,1XJ36@135619|Oceanospirillales	135619|Oceanospirillales	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_5636099_4	65393.PCC7424_2487	1.122e-38	150.0	2AFHA@1|root,315HT@2|Bacteria,1G5WD@1117|Cyanobacteria,3KIDV@43988|Cyanothece	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_5636099_3	497964.CfE428DRAFT_4518	4.817e-49	180.0	COG0791@1|root,COG0791@2|Bacteria,46VUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	NLP P60 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5636099_1	756272.Plabr_3129	1.992e-115	392.0	COG1680@1|root,COG1680@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HKD1_k127_5636099_2	234267.Acid_0055	8.844e-67	237.0	2AY4N@1|root,31Q6J@2|Bacteria,3Y7H6@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5636099_7	420662.Mpe_A0696	5.006e-15	78.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,2VHUC@28216|Betaproteobacteria,1KK1H@119065|unclassified Burkholderiales	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5636099_6	331678.Cphamn1_1944	3.075e-18	87.0	COG2827@1|root,COG2827@2|Bacteria	2|Bacteria	L	Endonuclease containing a URI domain	yazA	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HKD1_k127_5636099_5	497964.CfE428DRAFT_2905	1.671e-19	92.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5673744_8	1463881.KL591015_gene710	4.077e-18	89.0	COG4274@1|root,COG4274@2|Bacteria,2IN0N@201174|Actinobacteria	201174|Actinobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_5673744_5	485915.Dret_0286	2.009e-45	176.0	2DG8R@1|root,2ZUYV@2|Bacteria,1RG4Q@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
HKD1_k127_5673744_7	1396141.BATP01000028_gene2382	9.793e-19	89.0	COG1959@1|root,COG1959@2|Bacteria,46SPI@74201|Verrucomicrobia,2IVTS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_5673744_6	452637.Oter_3355	7.916e-37	156.0	COG3746@1|root,COG3746@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
HKD1_k127_5673744_3	864069.MicloDRAFT_00044330	4.481e-117	383.0	COG0600@1|root,COG0600@2|Bacteria,1PC26@1224|Proteobacteria,2VFP3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_5673744_2	1403819.BATR01000053_gene1611	3.643e-118	385.0	COG1116@1|root,COG1116@2|Bacteria,46TJD@74201|Verrucomicrobia,2ITUG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_5673744_1	864069.MicloDRAFT_00044350	1.935e-125	409.0	COG0715@1|root,COG0715@2|Bacteria,1RHDX@1224|Proteobacteria	1224|Proteobacteria	P	ABC transporter, substrate-binding protein, aliphatic sulfonates family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	iAF987.Gmet_0996	NMT1_2
HKD1_k127_5673744_4	497964.CfE428DRAFT_4289	2.392e-115	379.0	COG0657@1|root,COG0657@2|Bacteria,46U5Z@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Protein of unknown function (DUF1460)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1460
HKD1_k127_5673744_0	497964.CfE428DRAFT_2568	8.702e-137	443.0	COG2220@1|root,COG2220@2|Bacteria,46UIR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_5673744_9	994479.GL877878_gene3597	6.959e-17	88.0	COG2246@1|root,COG2246@2|Bacteria,2I4KJ@201174|Actinobacteria,4EDNU@85010|Pseudonocardiales	201174|Actinobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	GtrA,YfhO
HKD1_k127_5773996_1	946362.XP_004987954.1	6.156e-25	107.0	COG2159@1|root,KOG4245@2759|Eukaryota,38BZU@33154|Opisthokonta	33154|Opisthokonta	S	negative regulation of quinolinate biosynthetic process	ACMSD	GO:0001760,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006140,GO:0006520,GO:0006521,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006769,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009058,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009820,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0016043,GO:0016053,GO:0016054,GO:0016829,GO:0016830,GO:0016831,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019438,GO:0019439,GO:0019752,GO:0022607,GO:0030808,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032787,GO:0033238,GO:0034641,GO:0042402,GO:0042430,GO:0042436,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043648,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046218,GO:0046394,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046874,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051174,GO:0051186,GO:0051193,GO:0051196,GO:0051259,GO:0062012,GO:0062014,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0072330,GO:0072524,GO:0072525,GO:0080090,GO:0090357,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1902688,GO:1904984,GO:1904985,GO:1905003,GO:1905004,GO:1905012	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HKD1_k127_5773996_0	234267.Acid_1951	5.536e-138	461.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HKD1_k127_58278_8	497964.CfE428DRAFT_0212	1.747e-91	306.0	COG0217@1|root,COG0217@2|Bacteria,46SP3@74201|Verrucomicrobia	74201|Verrucomicrobia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD1_k127_58278_0	497964.CfE428DRAFT_0213	3.129e-176	563.0	COG1158@1|root,COG1158@2|Bacteria,46UQY@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	-	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_RNA_bind
HKD1_k127_58278_1	478741.JAFS01000001_gene1793	2.93e-152	515.0	COG1391@1|root,COG1391@2|Bacteria,46YXF@74201|Verrucomicrobia,37GG6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD1_k127_58278_9	497964.CfE428DRAFT_3166	3.122e-88	299.0	COG1597@1|root,COG1597@2|Bacteria,46SR5@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD1_k127_58278_11	497964.CfE428DRAFT_3167	3.159e-67	248.0	COG2982@1|root,COG2982@2|Bacteria	2|Bacteria	M	Protein involved in outer membrane biogenesis	-	-	-	ko:K07290	-	-	-	-	ko00000	9.B.121	-	-	AsmA,AsmA_2,DUF3971,DUF748
HKD1_k127_58278_13	240016.ABIZ01000001_gene4602	1.799e-43	165.0	COG0742@1|root,COG0742@2|Bacteria,46T62@74201|Verrucomicrobia,2IUEM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HKD1_k127_58278_4	497964.CfE428DRAFT_3169	4.414e-113	380.0	COG1519@1|root,COG1519@2|Bacteria,46SK9@74201|Verrucomicrobia	74201|Verrucomicrobia	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase domain protein	kdtA	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N
HKD1_k127_58278_22	1089439.KB902251_gene1515	6.125e-05	48.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_58278_3	883078.HMPREF9695_00530	4.844e-127	414.0	COG3239@1|root,COG3239@2|Bacteria,1NS28@1224|Proteobacteria,2TRD0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Sphingolipid Delta4-desaturase (DES)	-	-	1.14.18.5,1.14.19.17	ko:K04712	ko00600,ko01100,ko04071,map00600,map01100,map04071	M00094,M00099	R06519	RC00824	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_desaturase,Lipid_DES
HKD1_k127_58278_10	1519464.HY22_11180	1.578e-69	241.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_58278_2	391625.PPSIR1_34372	8.966e-142	462.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,42MM1@68525|delta/epsilon subdivisions,2WIU7@28221|Deltaproteobacteria,2YX7Y@29|Myxococcales	28221|Deltaproteobacteria	E	Beta-eliminating lyase	bioF1	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_58278_12	743722.Sph21_2689	5.791e-63	228.0	COG0558@1|root,COG0558@2|Bacteria,4NFW0@976|Bacteroidetes,1IU96@117747|Sphingobacteriia	976|Bacteroidetes	I	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD1_k127_58278_5	1297742.A176_03127	8.886e-113	376.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,42PYX@68525|delta/epsilon subdivisions,2WKSE@28221|Deltaproteobacteria,2YUVH@29|Myxococcales	28221|Deltaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_58278_19	944480.ATUV01000002_gene132	7.035e-15	83.0	COG0558@1|root,COG1213@1|root,COG0558@2|Bacteria,COG1213@2|Bacteria,1NN43@1224|Proteobacteria,432HN@68525|delta/epsilon subdivisions,2WYCV@28221|Deltaproteobacteria,2M7MC@213113|Desulfurellales	28221|Deltaproteobacteria	IM	CDP-alcohol phosphatidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD1_k127_58278_14	518766.Rmar_1196	2.249e-43	170.0	COG1213@1|root,COG1213@2|Bacteria,4P23X@976|Bacteroidetes	976|Bacteroidetes	M	Nucleotidyl transferase	-	-	2.7.7.74	ko:K07281	ko00562,map00562	-	R09669	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_58278_15	452637.Oter_4014	5.158e-42	165.0	COG0300@1|root,COG0300@2|Bacteria,46VV4@74201|Verrucomicrobia,3K7WJ@414999|Opitutae	414999|Opitutae	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_58278_6	497964.CfE428DRAFT_2977	2.695e-93	328.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_58278_20	351160.RCIX211	1.305e-13	84.0	COG1807@1|root,arCOG03981@1|root,arCOG00566@2157|Archaea,arCOG03981@2157|Archaea,2Y4H0@28890|Euryarchaeota	28890|Euryarchaeota	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_58278_18	177437.HRM2_42480	2.36e-29	123.0	COG0463@1|root,COG0463@2|Bacteria,1PWY6@1224|Proteobacteria,438K6@68525|delta/epsilon subdivisions,2WY00@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_58278_21	47763.JNZA01000012_gene6572	3.495e-12	79.0	COG2244@1|root,COG2244@2|Bacteria,2I4II@201174|Actinobacteria	201174|Actinobacteria	Q	Membrane protein involved in the export of O-antigen and teichoic acid	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_58278_7	1316936.K678_14714	3.865e-93	321.0	COG0859@1|root,COG0859@2|Bacteria,1PQIJ@1224|Proteobacteria,2V2XG@28211|Alphaproteobacteria,2JW5Y@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_58278_17	1123322.KB904658_gene1187	1.498e-31	141.0	COG1807@1|root,COG1807@2|Bacteria,2GP96@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_58278_16	497964.CfE428DRAFT_4057	2.539e-35	141.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_5862165_4	247490.KSU1_C0379	9.145e-104	351.0	COG3961@1|root,COG3961@2|Bacteria,2IY2K@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_5862165_0	497964.CfE428DRAFT_1447	0.0	1371.0	COG0265@1|root,COG0823@1|root,COG2234@1|root,COG0265@2|Bacteria,COG0823@2|Bacteria,COG2234@2|Bacteria,46T85@74201|Verrucomicrobia	74201|Verrucomicrobia	OU	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
HKD1_k127_5862165_3	251229.Chro_4406	1.621e-134	436.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,3VJ02@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5862165_2	251229.Chro_4406	4.802e-148	475.0	COG0167@1|root,COG0167@2|Bacteria,1G2B6@1117|Cyanobacteria,3VJ02@52604|Pleurocapsales	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5862165_1	1173024.KI912153_gene216	0.0	1126.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1145@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1145@2|Bacteria,1G2E2@1117|Cyanobacteria,1JKG2@1189|Stigonemataceae	1117|Cyanobacteria	C	Domain of unknown function	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_5863763_0	497964.CfE428DRAFT_2523	0.0	1598.0	COG0209@1|root,COG0209@2|Bacteria,46SG4@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_2_N,Ribonuc_red_lgC
HKD1_k127_5873725_2	1123248.KB893323_gene1603	1.062e-231	721.0	COG0277@1|root,COG0277@2|Bacteria,4NHFC@976|Bacteroidetes,1IUJ0@117747|Sphingobacteriia	976|Bacteroidetes	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	BBE,DUF805,FAD_binding_4
HKD1_k127_5873725_4	713586.KB900536_gene464	5.857e-68	236.0	COG1765@1|root,COG1765@2|Bacteria,1R9XU@1224|Proteobacteria,1SB92@1236|Gammaproteobacteria,1X0XT@135613|Chromatiales	135613|Chromatiales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_5873725_5	216596.RL2316	6.546e-67	243.0	COG2114@1|root,COG2114@2|Bacteria,1N6I7@1224|Proteobacteria,2U3M0@28211|Alphaproteobacteria,4B8MG@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4242,Guanylate_cyc
HKD1_k127_5873725_7	485913.Krac_10582	1.636e-25	111.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	ko:K11210	-	-	-	-	ko00000,ko01000	-	-	-	Glyoxalase
HKD1_k127_5873725_0	497964.CfE428DRAFT_4464	0.0	1452.0	COG0653@1|root,COG0653@2|Bacteria,46SJC@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_5873725_3	497964.CfE428DRAFT_6620	1.929e-70	243.0	COG2360@1|root,COG2360@2|Bacteria,46VHR@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD1_k127_5873725_1	497964.CfE428DRAFT_6618	2.418e-260	810.0	COG0519@1|root,COG0519@2|Bacteria,46SIW@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD1_k127_5998710_1	595460.RRSWK_00985	6.096e-78	271.0	COG1796@1|root,COG1796@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dpbF	-	3.1.11.5	ko:K02347,ko:K03581,ko:K04477	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,HHH_8
HKD1_k127_5998710_3	1131812.JQMS01000001_gene1964	3.44e-20	93.0	COG0236@1|root,COG0236@2|Bacteria,4NWTZ@976|Bacteroidetes,1IBDJ@117743|Flavobacteriia	976|Bacteroidetes	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD1_k127_5998710_0	272134.KB731324_gene5877	2.905e-140	456.0	COG0508@1|root,COG0508@2|Bacteria,1G0GX@1117|Cyanobacteria,1H8CP@1150|Oscillatoriales	2|Bacteria	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_5998710_2	1121403.AUCV01000068_gene2211	8.509e-69	237.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM Transketolase	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Transket_pyr,Transketolase_C
HKD1_k127_6039754_4	338966.Ppro_1442	4.152e-09	58.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,42XB2@68525|delta/epsilon subdivisions,2WT59@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_6039754_1	234267.Acid_4343	3.384e-89	297.0	COG3548@1|root,COG3548@2|Bacteria,3Y607@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD1_k127_6039754_2	251229.Chro_1450	2.513e-70	243.0	COG0346@1|root,COG0400@1|root,COG0346@2|Bacteria,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999,ko:K15975	-	-	-	-	ko00000	-	-	-	Abhydrolase_2,Glyoxalase
HKD1_k127_6039754_0	414996.IL38_11015	2.14e-115	379.0	COG0346@1|root,COG0346@2|Bacteria,2IAYN@201174|Actinobacteria,407X9@622450|Actinopolysporales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	ko:K15975	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_6039754_3	1038869.AXAN01000001_gene3848	2.748e-24	103.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,1KB0W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_6063372_13	497964.CfE428DRAFT_5925	1.994e-52	190.0	COG0125@1|root,COG0125@2|Bacteria,46ST1@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_6063372_8	497964.CfE428DRAFT_5924	1.744e-66	238.0	COG0470@1|root,COG0470@2|Bacteria,46T6T@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA polymerase III, delta subunit	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD1_k127_6063372_9	497964.CfE428DRAFT_3744	1.696e-65	231.0	COG1376@1|root,COG1376@2|Bacteria,46SUS@74201|Verrucomicrobia	74201|Verrucomicrobia	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_6063372_1	497964.CfE428DRAFT_3745	6.083e-191	603.0	COG0761@1|root,COG0761@2|Bacteria,46SAR@74201|Verrucomicrobia	74201|Verrucomicrobia	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	lytB	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD1_k127_6063372_3	1396418.BATQ01000119_gene3117	8.066e-106	352.0	COG1273@1|root,COG1273@2|Bacteria,46SB0@74201|Verrucomicrobia,2IVP3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Ku70/Ku80 beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	Ku
HKD1_k127_6063372_15	1121957.ATVL01000006_gene3201	1.99e-32	130.0	COG2259@1|root,COG2259@2|Bacteria,4PB3J@976|Bacteroidetes,47V4B@768503|Cytophagia	976|Bacteroidetes	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD1_k127_6063372_5	661478.OP10G_2718	2.396e-79	274.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	AXE1,DLH
HKD1_k127_6063372_4	204669.Acid345_1712	1.611e-101	348.0	COG1680@1|root,COG1680@2|Bacteria,3Y3WB@57723|Acidobacteria,2JJDH@204432|Acidobacteriia	204432|Acidobacteriia	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_6063372_0	452637.Oter_0618	8.004e-257	810.0	COG3591@1|root,COG3591@2|Bacteria,46UUQ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HKD1_k127_6063372_10	1318628.MARLIPOL_01155	1.641e-63	227.0	COG0500@1|root,COG2226@2|Bacteria,1QYC9@1224|Proteobacteria,1S4V4@1236|Gammaproteobacteria,46900@72275|Alteromonadaceae	1236|Gammaproteobacteria	Q	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HKD1_k127_6063372_14	113395.AXAI01000002_gene5313	5.969e-36	146.0	2EFWC@1|root,339NM@2|Bacteria,1NG7T@1224|Proteobacteria,2UY62@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6063372_17	1101190.ARWB01000001_gene1037	3.183e-16	90.0	2DRBV@1|root,33B5H@2|Bacteria,1NFAH@1224|Proteobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6063372_12	1122604.JONR01000031_gene1282	1.184e-55	202.0	COG4291@1|root,COG4291@2|Bacteria,1RIAS@1224|Proteobacteria,1SP50@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6063372_2	497964.CfE428DRAFT_4568	1.638e-169	544.0	28MGX@1|root,2ZATZ@2|Bacteria,46TJV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6063372_6	497964.CfE428DRAFT_4571	1.18e-78	267.0	COG0632@1|root,COG0632@2|Bacteria,46SZF@74201|Verrucomicrobia	74201|Verrucomicrobia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD1_k127_6063372_7	1396418.BATQ01000147_gene3590	1.487e-67	249.0	COG1807@1|root,COG1807@2|Bacteria,46SJQ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_6063372_18	666686.B1NLA3E_17995	4.249e-11	72.0	COG0671@1|root,COG0671@2|Bacteria,1V33Y@1239|Firmicutes,4HGAT@91061|Bacilli,1ZFPM@1386|Bacillus	91061|Bacilli	I	COG0671 Membrane-associated phospholipid phosphatase	pgpB1	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_6063372_11	1007103.AFHW01000029_gene1633	1.433e-56	211.0	COG2267@1|root,COG2267@2|Bacteria,1V0IY@1239|Firmicutes,4HBP3@91061|Bacilli,26T7K@186822|Paenibacillaceae	91061|Bacilli	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HKD1_k127_6077678_5	767434.Fraau_1625	2.825e-33	129.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RPQC@1236|Gammaproteobacteria,1X4TA@135614|Xanthomonadales	135614|Xanthomonadales	S	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6077678_6	397945.Aave_3231	8.862e-31	123.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2VMBM@28216|Betaproteobacteria,4ACH4@80864|Comamonadaceae	28216|Betaproteobacteria	C	Alcohol dehydrogenase GroES domain protein	adhA	-	1.1.1.1	ko:K13953,ko:K18382	ko00010,ko00071,ko00350,ko00625,ko00626,ko00640,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00640,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310,R10703	RC00050,RC00087,RC00088,RC00099,RC00116,RC00545,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6077678_7	1267534.KB906755_gene4783	1.117e-19	98.0	COG3247@1|root,COG3247@2|Bacteria,3Y5AN@57723|Acidobacteria,2JJYZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_6077678_3	1123392.AQWL01000010_gene2312	4.513e-139	452.0	COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria,2WGR7@28216|Betaproteobacteria,1KSBE@119069|Hydrogenophilales	119069|Hydrogenophilales	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6077678_4	639030.JHVA01000001_gene1491	2.485e-44	167.0	COG3247@1|root,COG3247@2|Bacteria,3Y5AN@57723|Acidobacteria,2JJYZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_6077678_2	1496688.ER33_02795	2.213e-140	456.0	COG2326@1|root,COG2326@2|Bacteria,1G159@1117|Cyanobacteria,22TKN@167375|Cyanobium	1117|Cyanobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_6077678_1	497964.CfE428DRAFT_1833	2.25e-157	515.0	COG1075@1|root,COG1075@2|Bacteria,46TIU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_6077678_0	323097.Nham_4370	0.0	1518.0	COG0637@1|root,COG1554@1|root,COG0637@2|Bacteria,COG1554@2|Bacteria,1MWJE@1224|Proteobacteria,2U1CG@28211|Alphaproteobacteria,3JWWP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glycosyl hydrolase family 65, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_65C,Glyco_hydro_65N,Glyco_hydro_65m,HAD_2
HKD1_k127_6077678_8	1127134.NOCYR_2830	7.387e-08	59.0	COG3631@1|root,COG3631@2|Bacteria,2IMNM@201174|Actinobacteria,4FYGS@85025|Nocardiaceae	201174|Actinobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_6148657_0	497964.CfE428DRAFT_1618	2.127e-196	621.0	COG0104@1|root,COG0104@2|Bacteria,46TDF@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_6148657_2	240016.ABIZ01000001_gene1257	1.048e-109	361.0	COG0020@1|root,COG0020@2|Bacteria,46SMY@74201|Verrucomicrobia,2IU5V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	-	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_6148657_3	497964.CfE428DRAFT_5920	1.029e-94	316.0	COG1028@1|root,COG1028@2|Bacteria,46SNA@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6148657_10	84531.JMTZ01000016_gene1122	2.383e-33	133.0	COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,1SFAZ@1236|Gammaproteobacteria,1X77B@135614|Xanthomonadales	135614|Xanthomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6148657_4	1249627.D779_0375	2.882e-91	310.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales	135613|Chromatiales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
HKD1_k127_6148657_9	208444.JNYY01000030_gene1157	4.449e-49	191.0	COG0500@1|root,COG2226@2|Bacteria,2H2IP@201174|Actinobacteria,4E9A2@85010|Pseudonocardiales	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12
HKD1_k127_6148657_12	1163408.UU9_14505	7.507e-16	81.0	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X85H@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxymyristoyl 3-hydroxydecanoyl-(acyl carrier protein)	-	-	-	-	-	-	-	-	-	-	-	-	FabA,PS-DH
HKD1_k127_6148657_5	443144.GM21_2187	2.325e-85	299.0	COG0446@1|root,COG0446@2|Bacteria,1QXXG@1224|Proteobacteria	1224|Proteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_6148657_7	485913.Krac_12208	2.7e-78	263.0	COG0225@1|root,COG0225@2|Bacteria	2|Bacteria	O	peptide-methionine (S)-S-oxide reductase activity	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K07305,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD1_k127_6148657_8	497964.CfE428DRAFT_5918	6.567e-70	244.0	COG0363@1|root,COG0363@2|Bacteria,46T8I@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	nagB	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD1_k127_6148657_1	497964.CfE428DRAFT_5278	2.961e-166	530.0	COG0451@1|root,COG0451@2|Bacteria,46TDU@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Male sterility protein	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase
HKD1_k127_6148657_6	497964.CfE428DRAFT_0749	9.015e-83	283.0	COG0327@1|root,COG0327@2|Bacteria	2|Bacteria	L	Belongs to the GTP cyclohydrolase I type 2 NIF3 family	ybgI	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010212,GO:0042802,GO:0043167,GO:0043169,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0050896	3.5.4.16	ko:K22391	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	NIF3
HKD1_k127_6148657_13	1502852.FG94_02381	1.752e-06	61.0	COG3577@1|root,COG3577@2|Bacteria,1N45S@1224|Proteobacteria,2WCDW@28216|Betaproteobacteria,477DQ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD1_k127_6155797_14	861299.J421_1112	9.158e-41	156.0	COG0534@1|root,COG0534@2|Bacteria,1ZT3Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_6155797_1	204669.Acid345_3443	3.214e-230	725.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_6155797_15	44251.PDUR_02070	2.875e-33	133.0	COG0454@1|root,COG0456@2|Bacteria,1V4GU@1239|Firmicutes,4HQNT@91061|Bacilli,26XKA@186822|Paenibacillaceae	91061|Bacilli	K	GCN5 family acetyltransferase	-	-	2.3.1.1	ko:K22477	ko00220,ko01210,ko01230,map00220,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetyltransf_1
HKD1_k127_6155797_3	670487.Ocepr_0368	7.894e-144	465.0	COG0182@1|root,COG0182@2|Bacteria,1WI3U@1297|Deinococcus-Thermus	2|Bacteria	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0017144,GO:0019509,GO:0019752,GO:0043094,GO:0043102,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046523,GO:0071265,GO:0071267,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD1_k127_6155797_13	1128427.KB904821_gene3730	6.715e-47	177.0	COG0235@1|root,COG0235@2|Bacteria,1G59N@1117|Cyanobacteria,1HANS@1150|Oscillatoriales	1117|Cyanobacteria	G	Class II Aldolase and Adducin N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD1_k127_6155797_5	404589.Anae109_1564	1.738e-129	422.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD1_k127_6155797_16	477184.KYC_19554	5.369e-30	129.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2VQ8D@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6155797_11	1396418.BATQ01000110_gene4753	1.814e-83	293.0	29D6U@1|root,3004T@2|Bacteria,46VBG@74201|Verrucomicrobia,2IUVG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6155797_7	240016.ABIZ01000001_gene2096	3.164e-119	391.0	28HK0@1|root,2Z7V0@2|Bacteria,46TSH@74201|Verrucomicrobia,2IU3Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
HKD1_k127_6155797_6	1267534.KB906754_gene2900	1.3e-122	404.0	COG4786@1|root,COG4786@2|Bacteria,3Y68I@57723|Acidobacteria,2JMAD@204432|Acidobacteriia	204432|Acidobacteriia	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD1_k127_6155797_10	1267534.KB906755_gene3906	2.656e-85	302.0	COG3064@1|root,COG3064@2|Bacteria,3Y6QP@57723|Acidobacteria	57723|Acidobacteria	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_6155797_18	1266925.JHVX01000013_gene1657	4.278e-21	98.0	COG2885@1|root,COG2885@2|Bacteria,1N6EM@1224|Proteobacteria,2VM27@28216|Betaproteobacteria,371W8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Belongs to the ompA family	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OmpA
HKD1_k127_6155797_12	1254432.SCE1572_28790	1.232e-75	261.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,43E08@68525|delta/epsilon subdivisions,2WZBV@28221|Deltaproteobacteria,2Z1SW@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6155797_4	177437.HRM2_38050	3.26e-137	445.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria,2MJ9S@213118|Desulfobacterales	28221|Deltaproteobacteria	H	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfk-1	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_6155797_8	497964.CfE428DRAFT_1140	1.212e-115	377.0	COG1611@1|root,COG1611@2|Bacteria,46SEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Possible lysine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
HKD1_k127_6155797_2	452637.Oter_0554	5.947e-197	623.0	COG1236@1|root,COG1236@2|Bacteria,46UFS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD1_k127_6155797_0	1396141.BATP01000059_gene2438	2.359e-231	725.0	COG0469@1|root,COG0469@2|Bacteria,46SBJ@74201|Verrucomicrobia,2ITNV@203494|Verrucomicrobiae	2|Bacteria	G	Pyruvate kinase, barrel domain	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_6158733_0	1267533.KB906738_gene2432	2.37e-274	854.0	COG0281@1|root,COG0281@2|Bacteria,3Y43V@57723|Acidobacteria,2JKSF@204432|Acidobacteriia	204432|Acidobacteriia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_6158733_6	1403819.BATR01000094_gene2922	3.191e-06	59.0	2DFF9@1|root,2ZRMT@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_6158733_2	1267534.KB906754_gene3681	4.931e-100	334.0	COG1028@1|root,COG1028@2|Bacteria,3Y42B@57723|Acidobacteria,2JIWX@204432|Acidobacteriia	204432|Acidobacteriia	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6158733_3	1266925.JHVX01000001_gene2530	4.869e-80	273.0	COG0783@1|root,COG0783@2|Bacteria,1RAC5@1224|Proteobacteria,2VM4X@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the Dps family	dps	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD1_k127_6158733_1	794903.OPIT5_05545	4.23e-149	478.0	COG0306@1|root,COG0306@2|Bacteria,46SDP@74201|Verrucomicrobia,3K7HD@414999|Opitutae	414999|Opitutae	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD1_k127_6158733_4	794903.OPIT5_05540	6.104e-61	217.0	COG1392@1|root,COG1392@2|Bacteria,46SSJ@74201|Verrucomicrobia,3K7IZ@414999|Opitutae	414999|Opitutae	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD1_k127_6203645_11	1396141.BATP01000020_gene28	3.136e-08	59.0	COG5338@1|root,COG5338@2|Bacteria	2|Bacteria	P	Protein conserved in bacteria	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2
HKD1_k127_6203645_9	583355.Caka_2436	6.429e-27	120.0	COG1596@1|root,COG1596@2|Bacteria,46YX8@74201|Verrucomicrobia,3K89Y@414999|Opitutae	414999|Opitutae	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_6203645_6	1396141.BATP01000020_gene26	2.083e-59	233.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,46YXA@74201|Verrucomicrobia,2IVHF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	DM	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
HKD1_k127_6203645_10	452637.Oter_3244	1.506e-23	115.0	COG3307@1|root,COG3307@2|Bacteria,46YCP@74201|Verrucomicrobia,3K9BC@414999|Opitutae	414999|Opitutae	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD1_k127_6203645_3	452637.Oter_2747	8.613e-87	306.0	COG2148@1|root,COG2148@2|Bacteria,46V7Y@74201|Verrucomicrobia,3K7HK@414999|Opitutae	414999|Opitutae	M	sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HKD1_k127_6203645_7	497964.CfE428DRAFT_3991	1.11e-58	211.0	2CAZH@1|root,2Z7RU@2|Bacteria,46SY1@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_6203645_0	886293.Sinac_5243	3.697e-132	427.0	COG0115@1|root,COG0115@2|Bacteria,2J2GT@203682|Planctomycetes	203682|Planctomycetes	H	Branched-chain amino acid aminotransferase 4-amino-4-deoxychorismate lyase	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_6203645_4	886293.Sinac_5242	1.1e-86	295.0	2C3PP@1|root,2Z954@2|Bacteria,2J2AE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6203645_8	497964.CfE428DRAFT_1046	1.759e-36	144.0	2EJM7@1|root,33DC3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6203645_2	1454004.AW11_01567	2.686e-102	345.0	COG0656@1|root,COG0656@2|Bacteria,1MX6S@1224|Proteobacteria,2VNCV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_6203645_1	1396141.BATP01000003_gene5228	1.07e-125	415.0	COG0451@1|root,COG0451@2|Bacteria,46XPQ@74201|Verrucomicrobia,2IWC3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6203645_5	1123060.JONP01000004_gene704	1.051e-67	239.0	COG3202@1|root,COG3202@2|Bacteria,1MVP5@1224|Proteobacteria,2U1N0@28211|Alphaproteobacteria,2JW2Q@204441|Rhodospirillales	204441|Rhodospirillales	C	ATP ADP translocase	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6211626_0	452637.Oter_1019	1.422e-160	513.0	COG2132@1|root,COG2132@2|Bacteria,46UN4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
HKD1_k127_6211626_1	1232410.KI421426_gene1437	2.28e-50	186.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria,43UQJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6254865_6	945713.IALB_1148	5.796e-18	89.0	COG2079@1|root,COG2079@2|Bacteria	2|Bacteria	S	2-methylcitrate dehydratase activity	prpD	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019679,GO:0019752,GO:0030312,GO:0032787,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0046459,GO:0047547,GO:0050896,GO:0071704,GO:0071944,GO:0072329,GO:1901575	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD1_k127_6254865_8	419947.MRA_2629A	7.48e-10	62.0	2DGZX@1|root,2ZXWY@2|Bacteria,2HDW7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	GO:0008150,GO:0040008,GO:0045927,GO:0048518,GO:0050789,GO:0065007	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6254865_7	102125.Xen7305DRAFT_00000310	7.055e-14	76.0	COG4113@1|root,COG4113@2|Bacteria	2|Bacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_6254865_3	382464.ABSI01000012_gene2201	3.587e-118	402.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
HKD1_k127_6254865_1	1122604.JONR01000004_gene851	5.895e-136	462.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_6254865_4	234267.Acid_7851	5.244e-109	381.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6254865_2	382464.ABSI01000012_gene2201	2.055e-124	420.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,TPR_11,TPR_16,TPR_7,TPR_8,Trans_reg_C
HKD1_k127_6254865_0	1122604.JONR01000004_gene851	1.866e-169	557.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_6254865_5	1122604.JONR01000004_gene851	3.988e-72	256.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T234@1236|Gammaproteobacteria,1X903@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_6324710_5	1123248.KB893381_gene1105	4.607e-117	395.0	COG3667@1|root,COG3667@2|Bacteria,4NICY@976|Bacteroidetes,1IWVR@117747|Sphingobacteriia	976|Bacteroidetes	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6324710_12	1338011.BD94_2977	1.576e-08	67.0	COG2132@1|root,COG2132@2|Bacteria,4NE3N@976|Bacteroidetes,1HWXY@117743|Flavobacteriia,34Q75@308865|Elizabethkingia	976|Bacteroidetes	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD1_k127_6324710_3	172088.AUGA01000045_gene6801	5.405e-125	415.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,3JTAS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	MA20_27925	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,Sugar_tr
HKD1_k127_6324710_7	1210884.HG799465_gene11459	2.465e-48	178.0	COG2940@1|root,COG2940@2|Bacteria,2J0I6@203682|Planctomycetes	203682|Planctomycetes	S	Cysteine-rich motif following a subset of SET domains	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD1_k127_6324710_9	697282.Mettu_3684	1.374e-31	126.0	2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,1SF7K@1236|Gammaproteobacteria,1XGMP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6324710_11	450851.PHZ_c0936	7.211e-09	60.0	2EI68@1|root,33BXK@2|Bacteria,1NH2E@1224|Proteobacteria,2UJAP@28211|Alphaproteobacteria,2KHIP@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6324710_8	1380390.JIAT01000011_gene2465	1.266e-45	170.0	COG3791@1|root,COG3791@2|Bacteria,2HQXY@201174|Actinobacteria,4CSQD@84995|Rubrobacteria	84995|Rubrobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_6324710_0	497964.CfE428DRAFT_2089	2.572e-252	785.0	COG0499@1|root,COG0499@2|Bacteria,46SGX@74201|Verrucomicrobia	74201|Verrucomicrobia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_6324710_1	497964.CfE428DRAFT_2088	4.65e-195	614.0	COG0192@1|root,COG0192@2|Bacteria,46S4V@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_6324710_2	497964.CfE428DRAFT_2087	1.173e-130	423.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,46SDC@74201|Verrucomicrobia	74201|Verrucomicrobia	KQ	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Methyltransf_11,Methyltransf_31
HKD1_k127_6324710_4	1122604.JONR01000031_gene1279	1.409e-117	403.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_6324710_10	349741.Amuc_1920	5.951e-27	121.0	COG3698@1|root,COG3698@2|Bacteria,46W6D@74201|Verrucomicrobia,2IUTV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD1_k127_6324710_6	871963.Desdi_2132	1.356e-57	210.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,263G2@186807|Peptococcaceae	186801|Clostridia	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2437,FAA_hydrolase
HKD1_k127_6381630_11	1396418.BATQ01000166_gene1899	1.651e-11	66.0	COG0352@1|root,COG0352@2|Bacteria,46T6K@74201|Verrucomicrobia,2IUF9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Thiamine monophosphate synthase	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_6381630_0	497964.CfE428DRAFT_2953	5.154e-217	681.0	COG0439@1|root,COG0439@2|Bacteria,46SIE@74201|Verrucomicrobia	74201|Verrucomicrobia	I	acetyl-CoA carboxylase	-	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_6381630_6	497964.CfE428DRAFT_2954	2.786e-42	160.0	COG0511@1|root,COG0511@2|Bacteria,46SXA@74201|Verrucomicrobia	74201|Verrucomicrobia	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD1_k127_6381630_3	497964.CfE428DRAFT_4120	1.199e-87	296.0	COG0564@1|root,COG0564@2|Bacteria,46V2B@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Pseudouridine synthase	-	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD1_k127_6381630_10	748247.AZKH_3370	4.587e-13	79.0	2F2FR@1|root,33VD5@2|Bacteria,1NUHA@1224|Proteobacteria,2W28U@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HKD1_k127_6381630_5	497964.CfE428DRAFT_0921	2.057e-76	261.0	COG4112@1|root,COG4112@2|Bacteria,46V3C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6381630_9	1244869.H261_00495	2.158e-13	74.0	2EG0F@1|root,339SF@2|Bacteria,1NJRZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6381630_2	1121957.ATVL01000010_gene392	1.363e-110	373.0	COG0501@1|root,COG0501@2|Bacteria,4NESF@976|Bacteroidetes,47KTS@768503|Cytophagia	976|Bacteroidetes	O	Zn-dependent protease with chaperone function	-	-	3.4.24.84	ko:K03799,ko:K06013	ko00900,ko01130,map00900,map01130	M00743	R09845	RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD1_k127_6381630_8	469617.FUAG_01663	1.686e-25	110.0	COG3952@1|root,COG3952@2|Bacteria,37AN1@32066|Fusobacteria	32066|Fusobacteria	S	Lipid A Biosynthesis N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	LAB_N
HKD1_k127_6381630_4	1123354.AUDR01000001_gene2018	1.84e-83	283.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2VJ5G@28216|Betaproteobacteria,1KRK3@119069|Hydrogenophilales	1224|Proteobacteria	M	Glycosyl transferase family 2	arnC	GO:0000271,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0009058,GO:0009059,GO:0009103,GO:0009987,GO:0016051,GO:0030258,GO:0030259,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0070085,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_6381630_1	1123354.AUDR01000001_gene2019	1.458e-166	530.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,1KTB7@119069|Hydrogenophilales	119069|Hydrogenophilales	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6381630_7	694440.JOMF01000004_gene1346	4.79e-39	158.0	COG0673@1|root,arCOG01622@2157|Archaea,2XTZY@28890|Euryarchaeota,2N9E7@224756|Methanomicrobia	224756|Methanomicrobia	S	Oxidoreductase family, C-terminal alpha/beta domain	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_6381630_12	497964.CfE428DRAFT_4131	2.778e-07	52.0	COG0074@1|root,COG0074@2|Bacteria,46TRM@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	-	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	Ligase_CoA
HKD1_k127_640454_0	497964.CfE428DRAFT_1607	0.0	1359.0	COG1048@1|root,COG1048@2|Bacteria,46SFS@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_640454_1	1396141.BATP01000028_gene2352	1.352e-61	216.0	COG1225@1|root,COG1225@2|Bacteria,46V63@74201|Verrucomicrobia,2IWQI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_640454_2	497964.CfE428DRAFT_0792	5.772e-40	154.0	COG2839@1|root,COG2839@2|Bacteria,46WEX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF456)	-	-	-	ko:K09793	-	-	-	-	ko00000	-	-	-	DUF456
HKD1_k127_640454_4	272624.lpg1742	0.0007057	48.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_640454_3	1027273.GZ77_01420	1.687e-36	142.0	2DNW1@1|root,32ZFG@2|Bacteria,1NBSM@1224|Proteobacteria,1S8G5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6435991_4	497964.CfE428DRAFT_6017	3.416e-71	246.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,NYN
HKD1_k127_6435991_0	234267.Acid_1100	4.809e-125	415.0	COG1696@1|root,COG1696@2|Bacteria,3Y4S9@57723|Acidobacteria	57723|Acidobacteria	M	PFAM membrane bound O-acyl transferase MBOAT	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HKD1_k127_6435991_8	56780.SYN_03077	1.82e-20	97.0	COG5652@1|root,COG5652@2|Bacteria,1PUUC@1224|Proteobacteria,43F3B@68525|delta/epsilon subdivisions,2X381@28221|Deltaproteobacteria,2MSC7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD1_k127_6435991_1	497964.CfE428DRAFT_2155	1.714e-99	334.0	COG1482@1|root,COG1482@2|Bacteria,46SVM@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM mannose-6-phosphate isomerase type I	manA	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	PMI_typeI
HKD1_k127_6435991_5	497964.CfE428DRAFT_2157	7.016e-44	161.0	COG3536@1|root,COG3536@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF971)	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	DUF971
HKD1_k127_6435991_2	497964.CfE428DRAFT_2158	2.521e-83	283.0	COG0325@1|root,COG0325@2|Bacteria,46SV2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD1_k127_6435991_9	1403819.BATR01000009_gene291	1.916e-09	66.0	2C7J2@1|root,33AYB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6435991_3	497964.CfE428DRAFT_0460	1.147e-78	269.0	COG1801@1|root,COG1801@2|Bacteria,46V5F@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_6435991_7	497964.CfE428DRAFT_6257	3.706e-24	105.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6453973_15	204669.Acid345_4193	7.79e-64	228.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria,2JKJ2@204432|Acidobacteriia	204432|Acidobacteriia	EU	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_6453973_19	1267533.KB906735_gene4559	1.319e-18	87.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria,2JJXU@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HKD1_k127_6453973_21	1454007.JAUG01000090_gene705	5.628e-14	76.0	COG1502@1|root,COG1502@2|Bacteria,4NMXS@976|Bacteroidetes,1ISBY@117747|Sphingobacteriia	976|Bacteroidetes	I	ORF6N domain	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
HKD1_k127_6453973_18	671143.DAMO_2744	3.573e-22	98.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N,SIS
HKD1_k127_6453973_9	309807.SRU_2814	2.155e-128	425.0	COG1228@1|root,COG4538@1|root,COG1228@2|Bacteria,COG4538@2|Bacteria,4PHV0@976|Bacteroidetes,1FJM6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,SnoaL_2
HKD1_k127_6453973_5	478741.JAFS01000001_gene1797	3.484e-147	469.0	COG2897@1|root,COG2897@2|Bacteria,46SFU@74201|Verrucomicrobia,37G92@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_6453973_2	497964.CfE428DRAFT_3903	6.502e-191	611.0	COG1640@1|root,COG1640@2|Bacteria,46SX0@74201|Verrucomicrobia	74201|Verrucomicrobia	G	PFAM glycoside hydrolase family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD1_k127_6453973_17	1123278.KB893388_gene5676	1.716e-27	117.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,47QBE@768503|Cytophagia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_6453973_1	497964.CfE428DRAFT_3901	1.133e-282	885.0	COG0210@1|root,COG0210@2|Bacteria,46S8H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_6453973_0	497964.CfE428DRAFT_4831	4.068e-285	887.0	COG0821@1|root,COG0821@2|Bacteria,46SEF@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD1_k127_6453973_4	1156937.MFUM_700088	1.075e-155	504.0	COG0750@1|root,COG0750@2|Bacteria,46S9B@74201|Verrucomicrobia,37G4E@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD1_k127_6453973_3	1403819.BATR01000096_gene3146	5.725e-157	503.0	COG0743@1|root,COG0743@2|Bacteria,46S90@74201|Verrucomicrobia,2ITI1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD1_k127_6453973_16	278957.ABEA03000041_gene2220	4.446e-30	122.0	COG0614@1|root,COG0614@2|Bacteria,46XIV@74201|Verrucomicrobia,3KA1P@414999|Opitutae	414999|Opitutae	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_6453973_10	497964.CfE428DRAFT_4834	4.876e-118	386.0	COG4589@1|root,COG4589@2|Bacteria,46SX9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cytidylyltransferase family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_6453973_20	1121861.KB899912_gene966	1.003e-15	80.0	COG0558@1|root,COG0558@2|Bacteria,1RHFC@1224|Proteobacteria,2UACA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	cdp-diacylglycerol--glycerol-3-phosphate	pgsAb	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD1_k127_6453973_12	1123060.JONP01000001_gene1304	1.024e-100	337.0	COG4589@1|root,COG4589@2|Bacteria,1MX58@1224|Proteobacteria,2TT9I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phosphatidate cytidylyltransferase	cdsA2	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_6453973_13	886293.Sinac_7153	1.171e-75	262.0	COG0204@1|root,COG0204@2|Bacteria,2IWS6@203682|Planctomycetes	203682|Planctomycetes	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_6453973_6	478741.JAFS01000002_gene242	4.226e-142	463.0	COG2262@1|root,COG2262@2|Bacteria,46SP4@74201|Verrucomicrobia,37FVB@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_6453973_14	497964.CfE428DRAFT_2338	2.632e-70	249.0	COG0324@1|root,COG0324@2|Bacteria,46T1C@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD1_k127_6453973_11	497964.CfE428DRAFT_1893	4.095e-104	344.0	COG0149@1|root,COG0149@2|Bacteria,46SNB@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD1_k127_6453973_8	1382359.JIAL01000001_gene209	4.532e-135	441.0	COG0126@1|root,COG0126@2|Bacteria,3Y2T7@57723|Acidobacteria,2JI0Z@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_6453973_7	1123070.KB899249_gene286	6.109e-140	451.0	COG0057@1|root,COG0057@2|Bacteria,46S59@74201|Verrucomicrobia,2ITXT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_6520014_6	234267.Acid_0814	1.046e-65	227.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_6520014_7	1173263.Syn7502_00101	1.888e-54	211.0	COG1807@1|root,COG1807@2|Bacteria,1GCHJ@1117|Cyanobacteria,1GZTK@1129|Synechococcus	1117|Cyanobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_6520014_11	118161.KB235922_gene5226	1.452e-17	90.0	2A4TS@1|root,30TF8@2|Bacteria,1GE0Y@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6520014_5	1454004.AW11_00497	4.161e-86	291.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VKBQ@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_6520014_10	580332.Slit_1242	2.153e-30	123.0	COG0664@1|root,COG0664@2|Bacteria,1N6WV@1224|Proteobacteria,2VWSV@28216|Betaproteobacteria,44WIM@713636|Nitrosomonadales	28216|Betaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_6520014_0	497964.CfE428DRAFT_2396	1.123e-302	940.0	COG0441@1|root,COG0441@2|Bacteria,46S5A@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_SAD
HKD1_k127_6520014_1	497964.CfE428DRAFT_3412	2.39e-233	731.0	COG0154@1|root,COG0154@2|Bacteria,46SCM@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_6520014_9	497964.CfE428DRAFT_3411	1.8e-32	129.0	COG0721@1|root,COG0721@2|Bacteria,46TA2@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD1_k127_6520014_8	497964.CfE428DRAFT_3409	4.176e-42	162.0	2FHDV@1|root,34981@2|Bacteria,46W9B@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6520014_4	1396418.BATQ01000127_gene2563	1.635e-128	421.0	COG1092@1|root,COG1092@2|Bacteria,46SJ5@74201|Verrucomicrobia,2ITMI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD1_k127_6520014_2	497964.CfE428DRAFT_2622	6.387e-133	430.0	COG0152@1|root,COG0152@2|Bacteria,46SIP@74201|Verrucomicrobia	74201|Verrucomicrobia	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD1_k127_6520014_3	556261.HMPREF0240_03243	3.674e-130	427.0	COG3119@1|root,COG3119@2|Bacteria,1TSUU@1239|Firmicutes,25CDH@186801|Clostridia,36WTZ@31979|Clostridiaceae	186801|Clostridia	P	Type I phosphodiesterase / nucleotide pyrophosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD1_k127_6522085_0	1173026.Glo7428_0932	1.44e-175	580.0	COG1216@1|root,COG5309@1|root,COG1216@2|Bacteria,COG5309@2|Bacteria,1G2MT@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HKD1_k127_6522085_1	335543.Sfum_3555	1.41e-134	449.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,43C63@68525|delta/epsilon subdivisions,2WTQK@28221|Deltaproteobacteria,2MSIN@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PFAM ABC transporter, transmembrane region	-	-	-	ko:K06147,ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_6522085_2	706587.Desti_5310	3.016e-14	79.0	COG1520@1|root,COG1520@2|Bacteria,1QV8R@1224|Proteobacteria	1224|Proteobacteria	G	6-phosphogluconolactonase activity	-	-	-	ko:K20952	ko05111,map05111	-	-	-	ko00000,ko00001	-	-	-	Beta-prism_lec,DUF4347,HYR,VCBS
HKD1_k127_654961_0	1118054.CAGW01000053_gene1386	5.837e-90	301.0	COG0179@1|root,COG0179@2|Bacteria,1VRIW@1239|Firmicutes,4HUFK@91061|Bacilli,26U89@186822|Paenibacillaceae	91061|Bacilli	Q	Fumarylacetoacetase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HKD1_k127_654961_1	1118054.CAGW01000053_gene1387	2.244e-58	214.0	COG0124@1|root,COG0124@2|Bacteria,1VSV5@1239|Firmicutes,4HUZY@91061|Bacilli,26WA6@186822|Paenibacillaceae	91061|Bacilli	J	histidyl-tRNA synthetase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_654961_2	240015.ACP_0684	2.677e-40	156.0	COG2020@1|root,COG2020@2|Bacteria,3Y55R@57723|Acidobacteria,2JJVJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	2.1.1.100	ko:K00587	ko00900,ko01130,map00900,map01130	-	R04496	RC00003,RC00460	ko00000,ko00001,ko01000	-	-	-	PEMT
HKD1_k127_654961_3	334390.LAF_0901	5.492e-18	94.0	COG2017@1|root,COG2017@2|Bacteria,1U26T@1239|Firmicutes,4HA4J@91061|Bacilli,3F3KT@33958|Lactobacillaceae	91061|Bacilli	G	Aldose 1-epimerase	lacX	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD1_k127_6563788_3	344747.PM8797T_25221	6.101e-12	72.0	2E4JC@1|root,32ZEE@2|Bacteria,2J0SF@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6563788_0	1499967.BAYZ01000139_gene157	1.015e-254	810.0	COG0466@1|root,COG0466@2|Bacteria,2NNNN@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_6563788_2	1396418.BATQ01000055_gene267	5.612e-22	100.0	COG0071@1|root,COG0071@2|Bacteria	2|Bacteria	O	Belongs to the small heat shock protein (HSP20) family	MA20_45160	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_6563788_1	1123073.KB899242_gene1451	1.936e-99	329.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,1RPIW@1236|Gammaproteobacteria,1X5RA@135614|Xanthomonadales	135614|Xanthomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD1_k127_6580940_17	452637.Oter_1802	2.621e-32	134.0	COG3241@1|root,COG3241@2|Bacteria,46W0N@74201|Verrucomicrobia,3K84F@414999|Opitutae	414999|Opitutae	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD1_k127_6580940_0	452637.Oter_1803	1.022e-315	976.0	COG4263@1|root,COG4263@2|Bacteria,46YT5@74201|Verrucomicrobia,3K7SZ@414999|Opitutae	414999|Opitutae	C	Cupredoxin-like domain	-	-	1.7.2.4	ko:K00376	ko00910,ko01120,map00910,map01120	M00529	R02804	RC02861	ko00000,ko00001,ko00002,ko01000	-	-	-	Cupredoxin_1
HKD1_k127_6580940_10	794903.OPIT5_23140	3.06e-68	237.0	COG4314@1|root,COG4314@2|Bacteria,46WQY@74201|Verrucomicrobia,3K7YT@414999|Opitutae	414999|Opitutae	C	lipoprotein involved in nitrous oxide reduction	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6580940_3	278957.ABEA03000176_gene2845	1.157e-113	385.0	COG3420@1|root,COG3420@2|Bacteria,46VQ1@74201|Verrucomicrobia,3K7SA@414999|Opitutae	414999|Opitutae	P	Domain present in carbohydrate binding proteins and sugar hydrolses	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD1_k127_6580940_12	309807.SRU_0311	1.152e-59	216.0	COG1131@1|root,COG1131@2|Bacteria,4PER8@976|Bacteroidetes,1FJGQ@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_6580940_18	794903.OPIT5_23125	2.677e-31	133.0	2C4QH@1|root,34C9E@2|Bacteria,46XU0@74201|Verrucomicrobia,3K83D@414999|Opitutae	414999|Opitutae	-	-	-	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	-
HKD1_k127_6580940_19	452637.Oter_0905	1.209e-22	102.0	COG4309@1|root,COG4309@2|Bacteria,46YQI@74201|Verrucomicrobia,3KA04@414999|Opitutae	414999|Opitutae	S	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD1_k127_6580940_9	497964.CfE428DRAFT_5882	5.23e-70	253.0	COG3213@1|root,COG3213@2|Bacteria,46VTH@74201|Verrucomicrobia	74201|Verrucomicrobia	P	NnrS protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrS
HKD1_k127_6580940_14	1121875.KB907550_gene772	1.456e-48	181.0	COG0500@1|root,COG0500@2|Bacteria,4PM90@976|Bacteroidetes,1IJN7@117743|Flavobacteriia	976|Bacteroidetes	Q	Protein of unknown function (DUF1698)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_6580940_7	452637.Oter_0906	1.978e-80	274.0	COG0664@1|root,COG0664@2|Bacteria,46VK1@74201|Verrucomicrobia,3K7W4@414999|Opitutae	74201|Verrucomicrobia	K	Crp Fnr family	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_6580940_5	383372.Rcas_1801	5.072e-100	342.0	COG2308@1|root,COG2308@2|Bacteria,2G7ZB@200795|Chloroflexi,3754D@32061|Chloroflexia	32061|Chloroflexia	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD1_k127_6580940_22	768710.DesyoDRAFT_1628	1.741e-06	53.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,24P7X@186801|Clostridia	186801|Clostridia	T	PFAM Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6580940_20	344747.PM8797T_24461	4.003e-16	79.0	COG0589@1|root,COG0589@2|Bacteria,2J042@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6580940_4	1122604.JONR01000031_gene1279	2.914e-107	382.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_6580940_6	886293.Sinac_1051	9.941e-83	307.0	COG0515@1|root,COG0515@2|Bacteria,2IY6U@203682|Planctomycetes	203682|Planctomycetes	KLT	COG0515 Serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD1_k127_6580940_16	1341181.FLJC2902T_08430	4.904e-37	145.0	COG0614@1|root,COG0614@2|Bacteria,4NS4Q@976|Bacteroidetes,1I3MV@117743|Flavobacteriia,2NWH0@237|Flavobacterium	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_6580940_13	497964.CfE428DRAFT_4864	1.631e-52	196.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6580940_15	330214.NIDE3859	2.417e-44	168.0	COG0071@1|root,COG0071@2|Bacteria,3J0TV@40117|Nitrospirae	40117|Nitrospirae	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_6580940_1	485915.Dret_1750	1.111e-254	808.0	COG0021@1|root,COG0021@2|Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N,XFP,XFP_N
HKD1_k127_6580940_11	438753.AZC_1197	4.932e-68	238.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,3EXXX@335928|Xanthobacteraceae	28211|Alphaproteobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	GO:0003674,GO:0003824,GO:0004733,GO:0006081,GO:0006725,GO:0006732,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009110,GO:0009987,GO:0016491,GO:0016638,GO:0016641,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0042822,GO:0042823,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046184,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HKD1_k127_6580940_2	290397.Adeh_1565	4.873e-147	488.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD1_k127_6580940_8	382464.ABSI01000010_gene3644	2.191e-75	259.0	COG0407@1|root,COG0407@2|Bacteria,46X9N@74201|Verrucomicrobia,2IV4H@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_658508_6	443144.GM21_1874	2.94e-08	56.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_658508_0	240016.ABIZ01000001_gene1308	7.001e-121	400.0	COG0226@1|root,COG0226@2|Bacteria,46UWT@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD1_k127_658508_1	497964.CfE428DRAFT_3934	1.791e-94	324.0	COG5002@1|root,COG5002@2|Bacteria,46SSA@74201|Verrucomicrobia	74201|Verrucomicrobia	T	PFAM ATP-binding region ATPase domain protein	-	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HKD1_k127_658508_3	497964.CfE428DRAFT_3933	2.788e-87	295.0	COG0745@1|root,COG0745@2|Bacteria,46SS3@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Two component transcriptional regulator, winged helix family	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_658508_2	497964.CfE428DRAFT_0373	1.505e-92	325.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5,Porin_O_P
HKD1_k127_6616622_0	1500894.JQNN01000001_gene1657	1.046e-209	663.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2W0VY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_6616622_2	1122604.JONR01000031_gene1279	2.392e-136	462.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_6616622_4	1163408.UU9_00909	1.116e-07	53.0	2EC7F@1|root,33660@2|Bacteria,1N839@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6616622_1	234267.Acid_7941	2.435e-155	503.0	COG0076@1|root,COG0076@2|Bacteria,3Y3S7@57723|Acidobacteria	57723|Acidobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD1_k127_6616622_3	234267.Acid_0572	7.424e-23	100.0	2EAHU@1|root,334M0@2|Bacteria,3Y5JU@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6806172_32	573413.Spirs_0104	1.192e-06	57.0	COG3797@1|root,COG3797@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HKD1_k127_6806172_30	1545915.JROG01000004_gene2589	6.092e-12	72.0	COG3631@1|root,COG3631@2|Bacteria,1NUJT@1224|Proteobacteria,2URVR@28211|Alphaproteobacteria,2KA61@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6806172_28	497964.CfE428DRAFT_5477	2.326e-19	95.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	NHL,SGL
HKD1_k127_6806172_26	1280946.HY29_02435	4.078e-24	108.0	COG0406@1|root,COG0406@2|Bacteria,1N92W@1224|Proteobacteria,2UGMI@28211|Alphaproteobacteria,43Y8Q@69657|Hyphomonadaceae	28211|Alphaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD1_k127_6806172_31	497964.CfE428DRAFT_0891	3.456e-10	68.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6806172_9	497964.CfE428DRAFT_1170	4.397e-62	226.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia	2|Bacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
HKD1_k127_6806172_1	941449.dsx2_2869	7.603e-180	572.0	COG0366@1|root,COG0366@2|Bacteria,1MX9V@1224|Proteobacteria,4316S@68525|delta/epsilon subdivisions,2WWX2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Alpha-amylase C-terminal beta-sheet domain	-	-	3.2.1.1	ko:K01176	ko00500,ko01100,ko04973,map00500,map01100,map04973	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amyl_C2,Alpha-amylase
HKD1_k127_6806172_8	240016.ABIZ01000001_gene1288	1.1e-69	238.0	COG0662@1|root,COG0662@2|Bacteria,46V2V@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_6806172_21	1300143.CCAV010000011_gene2807	2.607e-32	131.0	COG0346@1|root,COG0346@2|Bacteria,4NRRB@976|Bacteroidetes,1I2PP@117743|Flavobacteriia,3ZRNX@59732|Chryseobacterium	976|Bacteroidetes	E	Glyoxalase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_6806172_10	485913.Krac_10225	1.673e-60	219.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6806172_12	497964.CfE428DRAFT_4052	2.576e-56	201.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6806172_3	497964.CfE428DRAFT_4053	6.592e-142	456.0	COG1409@1|root,COG1409@2|Bacteria	2|Bacteria	S	acid phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_6806172_0	204669.Acid345_2243	7.43e-192	604.0	COG0436@1|root,COG0436@2|Bacteria,3Y3DG@57723|Acidobacteria,2JMAM@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class I and II	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_6806172_16	426117.M446_4758	1.71e-37	147.0	COG1917@1|root,COG1917@2|Bacteria,1MUY3@1224|Proteobacteria,2U5R0@28211|Alphaproteobacteria,1JV2T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	ChrR Cupin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_7
HKD1_k127_6806172_25	596151.DesfrDRAFT_2779	1.338e-27	117.0	COG2206@1|root,COG3707@1|root,COG2206@2|Bacteria,COG3707@2|Bacteria,1RAQS@1224|Proteobacteria,42MEJ@68525|delta/epsilon subdivisions,2WW4F@28221|Deltaproteobacteria,2MG1H@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,PAS,PAS_4,Response_reg
HKD1_k127_6806172_19	941449.dsx2_1298	2.251e-35	149.0	COG2203@1|root,COG3920@1|root,COG4191@1|root,COG2203@2|Bacteria,COG3920@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WJ5T@28221|Deltaproteobacteria,2MHID@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1
HKD1_k127_6806172_20	1095750.HMPREF9970_1402	5.252e-35	142.0	COG0637@1|root,COG0637@2|Bacteria,1V1DF@1239|Firmicutes,24FYY@186801|Clostridia,1HV3Z@1164882|Lachnoanaerobaculum	186801|Clostridia	S	NLI interacting factor-like phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD1_k127_6806172_2	204669.Acid345_2236	2.787e-173	550.0	COG1052@1|root,COG1052@2|Bacteria,3Y8C1@57723|Acidobacteria,2JNCS@204432|Acidobacteriia	204432|Acidobacteriia	CH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_6806172_18	1396418.BATQ01000144_gene3441	1.066e-36	143.0	COG0640@1|root,COG0640@2|Bacteria,46T9N@74201|Verrucomicrobia,2IVWD@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_6806172_6	296591.Bpro_1368	1.173e-94	316.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2VK34@28216|Betaproteobacteria,4AG99@80864|Comamonadaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HKD1_k127_6806172_17	436308.Nmar_0233	1.724e-37	144.0	COG3324@1|root,arCOG04946@2157|Archaea,41T3T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_6806172_15	1121373.KB903624_gene2431	4.326e-47	173.0	COG3832@1|root,COG3832@2|Bacteria,4NST9@976|Bacteroidetes,47R8V@768503|Cytophagia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_6806172_22	1472716.KBK24_0112150	1.589e-31	128.0	COG3832@1|root,COG3832@2|Bacteria,1RI7Y@1224|Proteobacteria,2VW09@28216|Betaproteobacteria,1K8QR@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_6806172_27	1207058.L53_14300	9.413e-24	104.0	COG3631@1|root,COG3631@2|Bacteria,1N487@1224|Proteobacteria,2UBRI@28211|Alphaproteobacteria,43YDG@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD1_k127_6806172_4	1122604.JONR01000031_gene1279	5.49e-121	413.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_6806172_23	485913.Krac_9387	2.126e-31	129.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,SnoaL_3
HKD1_k127_6806172_14	1056820.KB900700_gene1015	1.512e-47	176.0	COG0454@1|root,COG0456@2|Bacteria,1QU0C@1224|Proteobacteria,1S503@1236|Gammaproteobacteria,2PPW4@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_6806172_13	497964.CfE428DRAFT_4864	2.989e-50	187.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6806172_11	497964.CfE428DRAFT_1875	1.535e-57	228.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	DUF4062,FGE-sulfatase,Metallophos,NACHT,PEGA,Pkinase
HKD1_k127_6806172_5	1122604.JONR01000031_gene1279	1.725e-107	382.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1T5SE@1236|Gammaproteobacteria,1XDE6@135614|Xanthomonadales	135614|Xanthomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_6942971_11	269797.Mbar_A1220	1.644e-31	126.0	COG0053@1|root,arCOG01474@2157|Archaea,2XVEP@28890|Euryarchaeota,2N96U@224756|Methanomicrobia	224756|Methanomicrobia	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD1_k127_6942971_6	700598.Niako_6986	3.097e-103	349.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_6942971_12	497964.CfE428DRAFT_3022	1.047e-27	115.0	COG2363@1|root,COG2363@2|Bacteria,46T86@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function (DUF423)	-	-	-	-	-	-	-	-	-	-	-	-	DUF423
HKD1_k127_6942971_3	497964.CfE428DRAFT_2501	9.065e-126	419.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD1_k127_6942971_13	497964.CfE428DRAFT_3965	5.882e-26	114.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD1_k127_6942971_9	1403819.BATR01000191_gene6519	3.975e-34	135.0	COG5642@1|root,COG5642@2|Bacteria,46XIK@74201|Verrucomicrobia,2IW0M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HKD1_k127_6942971_8	1403819.BATR01000191_gene6518	5.325e-37	145.0	COG5654@1|root,COG5654@2|Bacteria,46XMG@74201|Verrucomicrobia,2IW6Y@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD1_k127_6942971_14	385682.AFSL01000025_gene2079	9.534e-23	107.0	COG1266@1|root,COG1266@2|Bacteria,4NGBZ@976|Bacteroidetes	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_6942971_4	382464.ABSI01000020_gene247	6.582e-119	394.0	COG0438@1|root,COG0438@2|Bacteria,46TCW@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_6942971_7	452637.Oter_2608	2.108e-94	315.0	2F12M@1|root,33U44@2|Bacteria,46V6U@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6942971_1	382464.ABSI01000020_gene244	3.28e-205	654.0	COG0591@1|root,COG0591@2|Bacteria,46UFJ@74201|Verrucomicrobia,2IVV1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HKD1_k127_6942971_0	926549.KI421517_gene2980	2.83e-269	855.0	COG2120@1|root,COG2120@2|Bacteria,4NE9K@976|Bacteroidetes,47KXK@768503|Cytophagia	976|Bacteroidetes	G	PFAM GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_6942971_5	234267.Acid_4617	2.408e-110	367.0	COG0457@1|root,COG0457@2|Bacteria,3Y4T0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
HKD1_k127_6942971_10	1122604.JONR01000008_gene2129	1.692e-33	138.0	COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_6942971_2	7739.XP_002595541.1	1.604e-146	479.0	COG1331@1|root,KOG2244@2759|Eukaryota,38VM1@33154|Opisthokonta,3BDEY@33208|Metazoa,3CTDG@33213|Bilateria,489FR@7711|Chordata	33208|Metazoa	O	spermatogenesis	SPATA20	GO:0000003,GO:0007276,GO:0007283,GO:0008150,GO:0019953,GO:0022414,GO:0032501,GO:0032504,GO:0044703,GO:0048232,GO:0048609,GO:0051704	-	-	-	-	-	-	-	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_6944891_9	497964.CfE428DRAFT_3542	3.387e-52	190.0	COG0863@1|root,COG2189@1|root,COG0863@2|Bacteria,COG2189@2|Bacteria,46TXQ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	N6_N4_Mtase
HKD1_k127_6944891_5	497964.CfE428DRAFT_0655	8.227e-127	414.0	COG2022@1|root,COG2022@2|Bacteria,46SHY@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG
HKD1_k127_6944891_8	497964.CfE428DRAFT_6518	2.205e-58	208.0	COG0242@1|root,COG0242@2|Bacteria,46SYF@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD1_k127_6944891_12	497964.CfE428DRAFT_6519	9.592e-30	124.0	COG0848@1|root,COG0848@2|Bacteria,46T7H@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Biopolymer transport protein ExbD/TolR	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD1_k127_6944891_7	497964.CfE428DRAFT_6520	1.182e-63	225.0	COG0811@1|root,COG0811@2|Bacteria,46T1R@74201|Verrucomicrobia	74201|Verrucomicrobia	U	MotA/TolQ/ExbB proton channel family	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD1_k127_6944891_6	497964.CfE428DRAFT_5454	4.722e-107	355.0	COG0122@1|root,COG0122@2|Bacteria,46SVK@74201|Verrucomicrobia	74201|Verrucomicrobia	L	8-oxoguanine DNA glycosylase, N-terminal domain	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
HKD1_k127_6944891_3	349741.Amuc_0171	2.975e-160	520.0	COG0591@1|root,COG0591@2|Bacteria,46SPP@74201|Verrucomicrobia,2ITZE@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Sodium:solute symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SSF
HKD1_k127_6944891_13	859657.RPSI07_2262	4.9e-26	110.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2VSJ0@28216|Betaproteobacteria,1K7UM@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	fdxA	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4,Fer4_4
HKD1_k127_6944891_17	331869.BAL199_06988	0.00073	44.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2U5UG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	MA20_19505	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_6944891_16	1267005.KB911260_gene3565	2.358e-05	49.0	COG3791@1|root,COG3791@2|Bacteria	2|Bacteria	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_6944891_15	331869.BAL199_06988	4.188e-19	89.0	COG3791@1|root,COG3791@2|Bacteria,1RCYS@1224|Proteobacteria,2U5UG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	MA20_19505	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD1_k127_6944891_1	497964.CfE428DRAFT_5191	3.606e-287	888.0	COG0459@1|root,COG0459@2|Bacteria,46S9U@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_6944891_11	497964.CfE428DRAFT_5190	3.921e-41	153.0	COG0234@1|root,COG0234@2|Bacteria,46SZ8@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_6944891_0	497964.CfE428DRAFT_5188	0.0	1079.0	COG0443@1|root,COG0443@2|Bacteria,46SDM@74201|Verrucomicrobia	74201|Verrucomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_6944891_4	497964.CfE428DRAFT_3384	2.087e-133	429.0	COG0207@1|root,COG0207@2|Bacteria,46SCY@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD1_k127_6944891_2	497964.CfE428DRAFT_4581	9.726e-246	779.0	COG0793@1|root,COG0793@2|Bacteria,46S88@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
HKD1_k127_6944891_10	497964.CfE428DRAFT_4580	1.271e-41	158.0	COG0491@1|root,COG0491@2|Bacteria,46T2E@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_69479_0	861299.J421_6202	2.23e-111	370.0	COG1064@1|root,COG1064@2|Bacteria,1ZSXS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_69479_1	1479239.JQMU01000001_gene1555	2.5e-44	165.0	COG3386@1|root,COG3386@2|Bacteria,1MVQM@1224|Proteobacteria,2U3TF@28211|Alphaproteobacteria,2K5IS@204457|Sphingomonadales	204457|Sphingomonadales	G	SMP-30/Gluconolaconase/LRE-like region	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HKD1_k127_69479_2	566466.NOR53_420	1.159e-42	162.0	2EM9G@1|root,33EYK@2|Bacteria,1P8EM@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6955513_1	204669.Acid345_2533	2.126e-99	335.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_6955513_0	497964.CfE428DRAFT_2729	3.5e-101	335.0	COG1209@1|root,COG1209@2|Bacteria,46T9Q@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Nucleotidyl transferase	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_6963563_3	1223410.KN050846_gene2424	1.916e-58	209.0	COG2964@1|root,COG2964@2|Bacteria	2|Bacteria	S	HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HTH_22,HisKA,PAS_3,PAS_6,PAS_9
HKD1_k127_6963563_6	1521187.JPIM01000030_gene1499	3.057e-40	157.0	COG4221@1|root,COG4221@2|Bacteria,2GBSD@200795|Chloroflexi,375PC@32061|Chloroflexia	32061|Chloroflexia	S	PFAM short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6963563_4	1128421.JAGA01000002_gene937	1.437e-48	189.0	COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_6963563_8	880073.Calab_1147	6.019e-19	100.0	COG0720@1|root,COG0720@2|Bacteria,2NR5B@2323|unclassified Bacteria	2|Bacteria	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_6963563_5	266117.Rxyl_2819	1.987e-41	162.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
HKD1_k127_6963563_2	671143.DAMO_0692	1.591e-58	211.0	COG0302@1|root,COG0302@2|Bacteria,2NPAT@2323|unclassified Bacteria	2|Bacteria	H	GTP cyclohydrolase I	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006066,GO:0006082,GO:0006139,GO:0006575,GO:0006725,GO:0006729,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008616,GO:0009058,GO:0009108,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0019752,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034404,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0040007,GO:0042455,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617,GO:1901657,GO:1901659	2.7.6.3,3.5.4.16	ko:K00950,ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R03503,R04639,R05046,R05048	RC00002,RC00017,RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.folE,iIT341.HP0928,iJN678.folE,iNJ661.Rv3609c	GTP_cyclohydroI
HKD1_k127_6963563_7	1386089.N865_10085	1.669e-38	149.0	2BVXR@1|root,32IG2@2|Bacteria,2IMT1@201174|Actinobacteria,4FGU2@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD1_k127_6963563_1	1122604.JONR01000033_gene37	3.372e-74	254.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,1RMQM@1236|Gammaproteobacteria,1X3YF@135614|Xanthomonadales	135614|Xanthomonadales	F	GTP cyclohydrolase	folE	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003933,GO:0003934,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006066,GO:0006725,GO:0006729,GO:0006732,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009108,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0017076,GO:0017144,GO:0018130,GO:0019001,GO:0019238,GO:0019438,GO:0019751,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034311,GO:0034312,GO:0034641,GO:0035639,GO:0036094,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046146,GO:0046165,GO:0046173,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_6963563_0	886293.Sinac_1066	1.169e-153	494.0	COG3508@1|root,COG3508@2|Bacteria,2J1YX@203682|Planctomycetes	203682|Planctomycetes	Q	homogentisate 1,2-dioxygenase	-	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD1_k127_7080165_18	1121288.AULL01000016_gene880	8.331e-22	105.0	2AC0T@1|root,311IM@2|Bacteria,4PGCB@976|Bacteroidetes,1IH7K@117743|Flavobacteriia,3ZT8H@59732|Chryseobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7080165_19	1385517.N800_06815	2.296e-10	68.0	2ET5N@1|root,311VW@2|Bacteria,1R3HC@1224|Proteobacteria,1T681@1236|Gammaproteobacteria,1XDI8@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7080165_5	240016.ABIZ01000001_gene4739	1.594e-158	510.0	COG0527@1|root,COG0527@2|Bacteria,46SIS@74201|Verrucomicrobia,2ITJM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_7080165_6	497964.CfE428DRAFT_1700	9.629e-148	475.0	COG0498@1|root,COG0498@2|Bacteria,46USE@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_7080165_1	583355.Caka_2205	1.472e-288	920.0	COG0022@1|root,COG0508@1|root,COG1071@1|root,COG0022@2|Bacteria,COG0508@2|Bacteria,COG1071@2|Bacteria,46TPF@74201|Verrucomicrobia,3K7MS@414999|Opitutae	414999|Opitutae	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_7080165_12	497964.CfE428DRAFT_2007	1.756e-68	242.0	COG0558@1|root,COG0558@2|Bacteria,46T66@74201|Verrucomicrobia	74201|Verrucomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_7080165_8	1396141.BATP01000003_gene4878	1.184e-123	412.0	COG1160@1|root,COG1160@2|Bacteria,46SJY@74201|Verrucomicrobia,2ITU6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	KH-domain-like of EngA bacterial GTPase enzymes, C-terminal	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD1_k127_7080165_4	497964.CfE428DRAFT_3456	8.689e-164	520.0	COG0714@1|root,COG0714@2|Bacteria,46S9V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_7080165_9	497964.CfE428DRAFT_3457	1.692e-123	403.0	COG1721@1|root,COG1721@2|Bacteria,46TNC@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_7080165_15	497964.CfE428DRAFT_3458	2.654e-38	149.0	2DR3K@1|root,33A0U@2|Bacteria,46WR8@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4381
HKD1_k127_7080165_10	497964.CfE428DRAFT_3459	1.76e-117	387.0	COG2304@1|root,COG2304@2|Bacteria,46TTR@74201|Verrucomicrobia	74201|Verrucomicrobia	S	von Willebrand factor type A domain	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA
HKD1_k127_7080165_7	497964.CfE428DRAFT_3460	1.204e-145	488.0	COG0457@1|root,COG2304@1|root,COG0457@2|Bacteria,COG2304@2|Bacteria,46SP8@74201|Verrucomicrobia	74201|Verrucomicrobia	J	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HKD1_k127_7080165_11	497964.CfE428DRAFT_3461	7.319e-94	331.0	COG0457@1|root,COG0457@2|Bacteria,46SZM@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Oxygen tolerance	-	-	-	-	-	-	-	-	-	-	-	-	BatD
HKD1_k127_7080165_14	497964.CfE428DRAFT_3462	3.663e-39	156.0	COG0457@1|root,COG0457@2|Bacteria,46W7V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7080165_3	649638.Trad_2886	1.327e-168	541.0	COG1057@1|root,COG1057@2|Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CTP_transf_like
HKD1_k127_7080165_13	1089548.KI783301_gene2344	1.25e-49	187.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,4HC44@91061|Bacilli	91061|Bacilli	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	mtnU	-	3.5.1.3	ko:K13566	ko00250,map00250	-	R00269,R00348	RC00010	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD1_k127_7080165_2	452637.Oter_1399	1.296e-261	822.0	COG1966@1|root,COG1966@2|Bacteria,46V26@74201|Verrucomicrobia,3K9J7@414999|Opitutae	414999|Opitutae	T	PFAM carbon starvation protein CstA	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD1_k127_7080165_17	1304275.C41B8_07522	2.939e-23	108.0	2EFWC@1|root,339NM@2|Bacteria,1NG7T@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7080165_0	1396141.BATP01000007_gene5676	3.528e-316	992.0	COG0525@1|root,COG0525@2|Bacteria,46SGP@74201|Verrucomicrobia,2IU1F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_7080165_16	261292.Nit79A3_1487	8.618e-37	146.0	2AM5X@1|root,31C0B@2|Bacteria,1PK3H@1224|Proteobacteria,2W8E1@28216|Betaproteobacteria,374C1@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7083266_1	497964.CfE428DRAFT_4164	5.962e-94	314.0	COG0483@1|root,COG0483@2|Bacteria,46T0Z@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Inositol monophosphatase family	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_7083266_4	497964.CfE428DRAFT_4165	6.467e-58	205.0	COG0245@1|root,COG0245@2|Bacteria,46T29@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD1_k127_7083266_0	497964.CfE428DRAFT_4166	4.213e-203	641.0	COG0215@1|root,COG0215@2|Bacteria,46SES@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD1_k127_7083266_6	583355.Caka_1992	1.389e-50	186.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HKD1_k127_7083266_3	323261.Noc_1229	4.703e-68	239.0	COG0457@1|root,COG0457@2|Bacteria,1QW39@1224|Proteobacteria,1S9J6@1236|Gammaproteobacteria,1X1GX@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HKD1_k127_7083266_5	497964.CfE428DRAFT_4864	8.299e-57	207.0	COG1595@1|root,COG1595@2|Bacteria,46VE8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7083266_2	530564.Psta_4044	1.399e-76	267.0	COG0515@1|root,COG0515@2|Bacteria,2IWY8@203682|Planctomycetes	203682|Planctomycetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_7084287_1	1122927.KB895414_gene5126	3.883e-110	367.0	COG0604@1|root,COG0604@2|Bacteria,1TQ0M@1239|Firmicutes,4HA8M@91061|Bacilli,26QXS@186822|Paenibacillaceae	91061|Bacilli	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_7084287_0	1267533.KB906737_gene2024	1.184e-110	368.0	COG0604@1|root,COG0604@2|Bacteria	2|Bacteria	C	NADPH:quinone reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_7084287_2	1267535.KB906767_gene1609	1.008e-93	314.0	arCOG07533@1|root,2ZF5I@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4386)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4386
HKD1_k127_7084287_3	768706.Desor_2301	2.848e-26	111.0	COG0454@1|root,COG0456@2|Bacteria,1VC2F@1239|Firmicutes,24JDW@186801|Clostridia,266C0@186807|Peptococcaceae	186801|Clostridia	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_7117252_1	204669.Acid345_4193	1.678e-168	539.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria,2JKJ2@204432|Acidobacteriia	204432|Acidobacteriia	EU	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_7117252_3	497964.CfE428DRAFT_2282	1.683e-65	229.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_7117252_2	497964.CfE428DRAFT_4598	7.159e-138	445.0	COG2876@1|root,COG2876@2|Bacteria,46SUJ@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_7117252_0	1123070.KB899252_gene912	2.234e-297	945.0	COG1197@1|root,COG1197@2|Bacteria,46S6Y@74201|Verrucomicrobia,2ITM9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	TRCF	-	-	-	-	-	-	-	-	-	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_7132796_3	497964.CfE428DRAFT_0263	4.519e-111	364.0	COG1183@1|root,COG1183@2|Bacteria,46SK0@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_7132796_4	497964.CfE428DRAFT_0262	1.496e-74	256.0	COG0688@1|root,COG0688@2|Bacteria,46VRI@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD1_k127_7132796_1	497964.CfE428DRAFT_4376	0.0	1106.0	COG0187@1|root,COG0187@2|Bacteria,46SDH@74201|Verrucomicrobia	74201|Verrucomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_7132796_6	290400.Jann_2787	1.797e-24	113.0	COG4424@1|root,COG4424@2|Bacteria,1RBDG@1224|Proteobacteria,2U6M2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Stf0 sulphotransferase	-	-	2.8.2.37	ko:K21014	-	-	-	-	ko00000,ko01000	-	-	-	Sulphotransf
HKD1_k127_7132796_0	497964.CfE428DRAFT_4373	0.0	1244.0	COG0188@1|root,COG0188@2|Bacteria,46SBE@74201|Verrucomicrobia	74201|Verrucomicrobia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_7132796_5	497964.CfE428DRAFT_2573	1.147e-30	127.0	COG1186@1|root,COG1186@2|Bacteria,46T84@74201|Verrucomicrobia	74201|Verrucomicrobia	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
HKD1_k127_7132796_2	1267533.KB906735_gene4847	3.028e-147	482.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	MA20_19960	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_7156898_16	497964.CfE428DRAFT_2912	2.157e-80	281.0	COG0083@1|root,COG0083@2|Bacteria,46STT@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_7156898_5	497964.CfE428DRAFT_2911	3.163e-145	475.0	COG1663@1|root,COG1663@2|Bacteria,46SBI@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD1_k127_7156898_7	204669.Acid345_2863	4.086e-138	447.0	COG3285@1|root,COG3285@2|Bacteria,3Y637@57723|Acidobacteria,2JM9H@204432|Acidobacteriia	204432|Acidobacteriia	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HKD1_k127_7156898_39	1128421.JAGA01000002_gene1863	1.944e-19	90.0	2EFVT@1|root,339N0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
HKD1_k127_7156898_29	1396418.BATQ01000133_gene4088	1.996e-46	176.0	COG3837@1|root,COG3837@2|Bacteria,46T0V@74201|Verrucomicrobia,2IU8V@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	AraC-like ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7156898_23	497964.CfE428DRAFT_1049	2.304e-59	209.0	COG3837@1|root,COG3837@2|Bacteria,46T0V@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7156898_26	1267533.KB906740_gene377	1.23e-55	196.0	COG0662@1|root,COG0662@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7156898_31	686340.Metal_4013	2.303e-36	146.0	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
HKD1_k127_7156898_6	497964.CfE428DRAFT_5137	5.208e-141	460.0	COG4591@1|root,COG4591@2|Bacteria,46SKZ@74201|Verrucomicrobia	74201|Verrucomicrobia	M	MacB-like periplasmic core domain	lolE	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_7156898_28	946362.XP_004995136.1	8.552e-49	178.0	COG3651@1|root,2S415@2759|Eukaryota,3AAWZ@33154|Opisthokonta	33154|Opisthokonta	S	Uncharacterized protein conserved in bacteria (DUF2237)	-	-	-	ko:K09966	-	-	-	-	ko00000	-	-	-	DUF2237
HKD1_k127_7156898_21	1403819.BATR01000146_gene4998	4.761e-62	218.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD1_k127_7156898_35	1173027.Mic7113_2796	3.903e-26	115.0	COG1514@1|root,COG1514@2|Bacteria,1GB04@1117|Cyanobacteria,1HGNX@1150|Oscillatoriales	1117|Cyanobacteria	J	Cyclic phosphodiesterase-like	-	-	-	-	-	-	-	-	-	-	-	-	CPDase
HKD1_k127_7156898_19	497964.CfE428DRAFT_4990	1.271e-65	248.0	COG3071@1|root,COG3071@2|Bacteria,46VFP@74201|Verrucomicrobia	74201|Verrucomicrobia	H	HemY protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7156898_14	1403819.BATR01000130_gene4633	1.919e-89	312.0	COG0628@1|root,COG0628@2|Bacteria,46VTV@74201|Verrucomicrobia,2ITP8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_7156898_11	497964.CfE428DRAFT_5668	4.685e-119	407.0	COG0457@1|root,COG0457@2|Bacteria,46V4J@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_8
HKD1_k127_7156898_12	661478.OP10G_1948	7.827e-118	409.0	COG0339@1|root,COG0339@2|Bacteria	2|Bacteria	E	metalloendopeptidase activity	prlC	-	3.4.24.15,3.4.24.70	ko:K01392,ko:K01414	ko04614,ko05143,map04614,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M3
HKD1_k127_7156898_30	1307759.JOMJ01000003_gene1287	3.275e-46	174.0	COG2095@1|root,COG2095@2|Bacteria,1N689@1224|Proteobacteria,42UPI@68525|delta/epsilon subdivisions,2WNQP@28221|Deltaproteobacteria,2MBGT@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	UPF0056 inner membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD1_k127_7156898_3	497964.CfE428DRAFT_6681	1.558e-214	674.0	COG0535@1|root,COG0535@2|Bacteria,46V38@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Domain of unknown function (DUF3463)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
HKD1_k127_7156898_1	497964.CfE428DRAFT_6644	3.097e-285	889.0	COG1657@1|root,COG1657@2|Bacteria,46TK5@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Squalene-hopene cyclase N-terminal domain	sqhC	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD1_k127_7156898_13	326423.RBAM_023340	9.561e-97	319.0	COG0605@1|root,COG0605@2|Bacteria,1TPXT@1239|Firmicutes,4HA6U@91061|Bacilli,1ZBWK@1386|Bacillus	91061|Bacilli	P	radicals which are normally produced within the cells and which are toxic to biological systems	sodA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0003824,GO:0004784,GO:0006801,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016721,GO:0019430,GO:0033554,GO:0034599,GO:0034614,GO:0042221,GO:0044237,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071450,GO:0071451,GO:0072593,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1901701,GO:1990748	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_7156898_4	497964.CfE428DRAFT_1483	1.958e-199	628.0	COG0436@1|root,COG0436@2|Bacteria,46TMR@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_7156898_2	497964.CfE428DRAFT_4772	3.492e-222	698.0	COG3011@1|root,COG3011@2|Bacteria,46U84@74201|Verrucomicrobia	2|Bacteria	S	Lipase maturation factor	LMF	-	-	-	-	-	-	-	-	-	-	-	LMF1
HKD1_k127_7156898_15	497964.CfE428DRAFT_6171	1.548e-86	308.0	COG1073@1|root,COG1073@2|Bacteria,46VGX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7156898_25	497964.CfE428DRAFT_6170	1.709e-56	219.0	COG0204@1|root,COG0204@2|Bacteria,46VPE@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Phosphate acyltransferases	-	-	-	-	-	-	-	-	-	-	-	-	Acyltransferase
HKD1_k127_7156898_0	1121472.AQWN01000011_gene1225	9.532e-302	955.0	COG0506@1|root,COG1012@1|root,COG0506@2|Bacteria,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,247W7@186801|Clostridia,26131@186807|Peptococcaceae	186801|Clostridia	C	Belongs to the aldehyde dehydrogenase family	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh,Pro_dh
HKD1_k127_7156898_41	497964.CfE428DRAFT_0891	8.063e-11	70.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7156898_9	517418.Ctha_0233	1.025e-134	457.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1FDRS@1090|Chlorobi	1090|Chlorobi	C	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin_7
HKD1_k127_7156898_20	498211.CJA_3158	3.118e-65	229.0	COG1225@1|root,COG1225@2|Bacteria,1RD2X@1224|Proteobacteria,1S3TJ@1236|Gammaproteobacteria,1FHI6@10|Cellvibrio	1236|Gammaproteobacteria	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_7156898_22	497964.CfE428DRAFT_4825	1.127e-61	222.0	COG0300@1|root,COG0300@2|Bacteria,46V6A@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Enoyl-(Acyl carrier protein) reductase	dltE	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD1_k127_7156898_18	497964.CfE428DRAFT_5456	2.874e-68	240.0	COG1187@1|root,COG1187@2|Bacteria,46SWQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Belongs to the pseudouridine synthase RsuA family	rsuA	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_7156898_40	497964.CfE428DRAFT_3212	5.309e-17	83.0	2DSQH@1|root,33H1Z@2|Bacteria,46TBQ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7156898_24	1156937.MFUM_810025	3.528e-58	225.0	COG1807@1|root,COG1807@2|Bacteria,46SXK@74201|Verrucomicrobia,37G5C@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_7156898_27	497964.CfE428DRAFT_5348	9.066e-53	190.0	COG0824@1|root,COG0824@2|Bacteria,46T37@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Thioesterase-like superfamily	fcbC	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD1_k127_7156898_34	452637.Oter_3771	3.302e-33	140.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	PE-PPE,VKG_Carbox
HKD1_k127_7156898_36	1121324.CLIT_11c02670	6.239e-25	109.0	2E74N@1|root,331P2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7156898_10	497964.CfE428DRAFT_5303	2.226e-121	401.0	COG3481@1|root,COG3481@2|Bacteria,46SYB@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD
HKD1_k127_7156898_8	1128421.JAGA01000003_gene2811	2.26e-137	449.0	COG0498@1|root,COG0498@2|Bacteria,2NP42@2323|unclassified Bacteria	2|Bacteria	E	Threonine synthase	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_7156898_32	469383.Cwoe_1697	6.563e-35	146.0	COG5607@1|root,COG5607@2|Bacteria,2HQYQ@201174|Actinobacteria,4CSRG@84995|Rubrobacteria	84995|Rubrobacteria	S	CHAD	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD1_k127_7156898_33	1313304.CALK_1905	1.215e-33	135.0	COG2954@1|root,COG2954@2|Bacteria	2|Bacteria	S	triphosphatase activity	-	GO:0003674,GO:0003824,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0050355	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD1_k127_7156898_37	627192.SLG_33000	4.149e-20	92.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2K0Q8@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD1_k127_7158523_5	478741.JAFS01000002_gene444	5.988e-75	268.0	COG1030@1|root,COG1030@2|Bacteria,46TAS@74201|Verrucomicrobia,37G9H@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	O	NfeD-like C-terminal, partner-binding	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD,SDH_sah
HKD1_k127_7158523_0	497964.CfE428DRAFT_1568	2.495e-185	597.0	COG0358@1|root,COG0358@2|Bacteria,46S6C@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,Toprim_2,Toprim_N,zf-CHC2
HKD1_k127_7158523_1	716544.wcw_1949	1.911e-150	498.0	COG0568@1|root,COG0568@2|Bacteria,2JFP5@204428|Chlamydiae	204428|Chlamydiae	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_7158523_2	497964.CfE428DRAFT_3687	6.219e-122	400.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,46SFQ@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD1_k127_7158523_4	497964.CfE428DRAFT_0336	1.147e-79	291.0	COG0457@1|root,COG1196@1|root,COG0457@2|Bacteria,COG1196@2|Bacteria,46T1H@74201|Verrucomicrobia	2|Bacteria	D	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Mob_Pre,TPR_11
HKD1_k127_7158523_3	246197.MXAN_2622	3.541e-85	288.0	COG3361@1|root,COG3361@2|Bacteria	2|Bacteria	S	conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
HKD1_k127_7158523_6	452637.Oter_2685	3.834e-63	220.0	COG1048@1|root,COG1048@2|Bacteria,46SFS@74201|Verrucomicrobia,3K7UQ@414999|Opitutae	414999|Opitutae	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_7168952_9	240015.ACP_2574	5.672e-133	441.0	COG1008@1|root,COG1008@2|Bacteria,3Y6ZF@57723|Acidobacteria,2JMB1@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_7168952_1	1267534.KB906754_gene3773	3.418e-207	664.0	COG1009@1|root,COG1009@2|Bacteria,3Y76V@57723|Acidobacteria,2JMJJ@204432|Acidobacteriia	204432|Acidobacteriia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus	-	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_7168952_19	1267534.KB906754_gene3774	5.189e-29	122.0	COG0713@1|root,COG0713@2|Bacteria,3Y835@57723|Acidobacteria,2JN5T@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_7168952_22	1123253.AUBD01000008_gene450	9.469e-12	71.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S4ZA@1236|Gammaproteobacteria,1X5QE@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_7168952_6	1267534.KB906754_gene3776	5.32e-142	461.0	COG1005@1|root,COG1005@2|Bacteria,3Y6TS@57723|Acidobacteria,2JKJQ@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_7168952_18	497964.CfE428DRAFT_6698	1.22e-44	168.0	COG0622@1|root,COG0622@2|Bacteria,46SXW@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD1_k127_7168952_3	497964.CfE428DRAFT_2041	4.496e-201	652.0	COG1452@1|root,COG1452@2|Bacteria,46SJX@74201|Verrucomicrobia	74201|Verrucomicrobia	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	imp	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
HKD1_k127_7168952_2	497964.CfE428DRAFT_2040	9.103e-205	644.0	COG1004@1|root,COG1004@2|Bacteria,46S6E@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ugd	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_7168952_12	497964.CfE428DRAFT_2039	1.437e-117	391.0	COG0144@1|root,COG0144@2|Bacteria,46TY0@74201|Verrucomicrobia	74201|Verrucomicrobia	J	16S rRNA methyltransferase RsmB/F	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD1_k127_7168952_4	497964.CfE428DRAFT_0200	1.254e-169	539.0	COG2309@1|root,COG2309@2|Bacteria,46SAI@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM peptidase M29 aminopeptidase II	-	-	-	ko:K19689	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M29
HKD1_k127_7168952_23	1307759.JOMJ01000004_gene2483	7.702e-05	57.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MABK@213115|Desulfovibrionales	28221|Deltaproteobacteria	NU	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4
HKD1_k127_7168952_15	497964.CfE428DRAFT_5015	2.395e-69	243.0	COG1521@1|root,COG1521@2|Bacteria,46T0X@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD1_k127_7168952_8	497964.CfE428DRAFT_0073	4.804e-141	456.0	COG0113@1|root,COG0113@2|Bacteria,46S91@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD1_k127_7168952_16	497964.CfE428DRAFT_6199	1.394e-48	183.0	2ECN9@1|root,336K5@2|Bacteria,46T7K@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7168952_21	1121914.AUDW01000024_gene108	2.392e-14	85.0	2DRCD@1|root,33B7A@2|Bacteria,1UKDM@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7168952_17	870187.Thini_1988	4.34e-47	184.0	COG3170@1|root,COG3170@2|Bacteria	2|Bacteria	NU	translation initiation factor activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1631,DUF2510,PknH_C,TIR_2
HKD1_k127_7168952_0	497964.CfE428DRAFT_0265	1.823e-231	727.0	COG0696@1|root,COG0696@2|Bacteria,46U4C@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD1_k127_7168952_10	497964.CfE428DRAFT_3489	6.834e-125	414.0	COG1785@1|root,COG1785@2|Bacteria,46TE7@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Alkaline phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Alk_phosphatase
HKD1_k127_7168952_11	439235.Dalk_1883	6.11e-124	422.0	COG0457@1|root,COG0457@2|Bacteria,1RKQQ@1224|Proteobacteria,42T9T@68525|delta/epsilon subdivisions,2WPQ0@28221|Deltaproteobacteria,2MN67@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_16,TPR_2,TPR_8
HKD1_k127_7168952_14	706587.Desti_1819	5.794e-112	384.0	COG1807@1|root,COG1807@2|Bacteria,1R3XN@1224|Proteobacteria,42P5N@68525|delta/epsilon subdivisions,2WKH2@28221|Deltaproteobacteria,2MQ8W@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_7168952_7	1131269.AQVV01000048_gene2100	6.851e-142	473.0	COG0457@1|root,COG0457@2|Bacteria	1131269.AQVV01000048_gene2100|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7168952_5	1131269.AQVV01000048_gene2100	1.012e-145	486.0	COG0457@1|root,COG0457@2|Bacteria	1131269.AQVV01000048_gene2100|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7168952_13	595460.RRSWK_03709	4.58e-114	396.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2IYMF@203682|Planctomycetes	203682|Planctomycetes	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_7168952_20	936455.KI421499_gene3169	5.103e-27	122.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,3JRSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8
HKD1_k127_7183701_3	697282.Mettu_4325	9.233e-19	89.0	COG0607@1|root,30JW6@2|Bacteria,1PGPU@1224|Proteobacteria,1RUXS@1236|Gammaproteobacteria,1XGR5@135618|Methylococcales	135618|Methylococcales	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD1_k127_7183701_2	452637.Oter_1455	1.289e-54	206.0	COG0845@1|root,COG0845@2|Bacteria,46US2@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_7183701_0	452637.Oter_1454	0.0	1374.0	COG0841@1|root,COG0841@2|Bacteria,46SER@74201|Verrucomicrobia	74201|Verrucomicrobia	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_7183701_1	1396418.BATQ01000136_gene3721	8.423e-151	492.0	28P28@1|root,2ZBYC@2|Bacteria,46V4V@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7183701_4	555079.Toce_0893	2.434e-17	92.0	COG1082@1|root,COG1082@2|Bacteria,1UZFB@1239|Firmicutes,247UI@186801|Clostridia,42HII@68295|Thermoanaerobacterales	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_7183701_5	395493.BegalDRAFT_2260	0.0002383	48.0	COG1361@1|root,COG2373@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2373@2|Bacteria,COG4932@2|Bacteria,1QUEG@1224|Proteobacteria	1224|Proteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Cadherin,Cadherin_3,Calx-beta,FecR,PKD,SdrD_B,TGFb_propeptide
HKD1_k127_7184381_11	926569.ANT_19570	4.653e-24	111.0	COG1807@1|root,COG1807@2|Bacteria,2G79E@200795|Chloroflexi	200795|Chloroflexi	M	Protein of unknown function (DUF2723)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
HKD1_k127_7184381_9	1403819.BATR01000181_gene6237	1.901e-44	164.0	COG1013@1|root,COG1013@2|Bacteria,46SRY@74201|Verrucomicrobia,2IV9I@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	-	-	-	-	-	-	-	-	-	-	TPP_enzyme_C
HKD1_k127_7184381_6	478741.JAFS01000001_gene1555	3.965e-88	300.0	28I4Y@1|root,2Z88D@2|Bacteria,46VRF@74201|Verrucomicrobia,37GMA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7184381_1	382464.ABSI01000017_gene26	3.042e-250	788.0	COG0674@1|root,COG0674@2|Bacteria,46SM9@74201|Verrucomicrobia,2IV6Q@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	-	-	-	-	-	-	-	-	-	-	PFOR_II,POR,POR_N
HKD1_k127_7184381_0	479434.Sthe_2668	4.692e-260	837.0	COG4447@1|root,COG4447@2|Bacteria,2G678@200795|Chloroflexi,27YSS@189775|Thermomicrobia	189775|Thermomicrobia	S	PFAM glycosyl hydrolase BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_7184381_10	1173263.Syn7502_02560	2.062e-33	132.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_7184381_2	497964.CfE428DRAFT_5023	7.992e-165	527.0	COG0577@1|root,COG0577@2|Bacteria,46U7K@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7184381_5	452637.Oter_3644	1.455e-99	331.0	COG1136@1|root,COG1136@2|Bacteria,46SKR@74201|Verrucomicrobia,3K7HB@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7184381_4	497964.CfE428DRAFT_5021	2.586e-130	426.0	COG0845@1|root,COG0845@2|Bacteria,46TJP@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_7184381_7	497964.CfE428DRAFT_2346	7.469e-81	278.0	COG3694@1|root,COG3694@2|Bacteria,46VPX@74201|Verrucomicrobia	74201|Verrucomicrobia	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_6
HKD1_k127_7184381_3	497964.CfE428DRAFT_2638	6.396e-137	448.0	COG0508@1|root,COG0508@2|Bacteria,46SD3@74201|Verrucomicrobia	74201|Verrucomicrobia	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_7184381_12	204669.Acid345_3240	1.75e-08	65.0	COG1266@1|root,COG1266@2|Bacteria,3Y5CJ@57723|Acidobacteria,2JJVP@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_7184381_8	264462.Bd2731	1.272e-72	250.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2MSPX@213481|Bdellovibrionales,2WIR7@28221|Deltaproteobacteria	213481|Bdellovibrionales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	lpdA-1	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_7223490_3	452637.Oter_1019	1.161e-85	286.0	COG2132@1|root,COG2132@2|Bacteria,46UN4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Cu-oxidase_3
HKD1_k127_7223490_1	1128421.JAGA01000003_gene2922	1.058e-98	328.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
HKD1_k127_7223490_2	383372.Rcas_0817	4.026e-96	323.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_7223490_6	1266925.JHVX01000002_gene1045	8.018e-42	159.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,2VUKU@28216|Betaproteobacteria,373FF@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_7223490_4	118173.KB235914_gene303	2.454e-64	227.0	COG2846@1|root,COG2846@2|Bacteria,1GBB9@1117|Cyanobacteria	1117|Cyanobacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD1_k127_7223490_7	570952.ATVH01000015_gene1235	3.107e-34	136.0	COG1959@1|root,COG1959@2|Bacteria,1N05H@1224|Proteobacteria,2UBZM@28211|Alphaproteobacteria,2JT74@204441|Rhodospirillales	204441|Rhodospirillales	K	transcriptional regulator	-	-	-	ko:K13771	ko05132,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	Rrf2
HKD1_k127_7223490_0	204669.Acid345_2395	8.94e-117	411.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_16,TPR_2,TPR_8
HKD1_k127_7223490_5	1183438.GKIL_3396	1.16e-57	206.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_7223490_8	65393.PCC7424_1997	3.291e-18	94.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1G4IS@1117|Cyanobacteria,3KKQ9@43988|Cyanothece	1117|Cyanobacteria	QU	PFAM Hemolysin-type calcium-binding region	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind
HKD1_k127_7266772_37	497964.CfE428DRAFT_0729	2.439e-05	51.0	298B0@1|root,2ZVGI@2|Bacteria,46WFY@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7266772_5	481448.Minf_0245	2.574e-180	571.0	COG0516@1|root,COG0516@2|Bacteria,46W51@74201|Verrucomicrobia,37FWR@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	F	IMP dehydrogenase / GMP reductase domain	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD1_k127_7266772_6	1408254.T458_16735	2.451e-164	527.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,4H9SD@91061|Bacilli,26QJA@186822|Paenibacillaceae	91061|Bacilli	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF3	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_7266772_38	1089548.KI783301_gene1	2.507e-05	46.0	2DG4E@1|root,2ZUFG@2|Bacteria,1W47E@1239|Firmicutes,4I1MM@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7266772_24	497964.CfE428DRAFT_6117	8.698e-57	205.0	COG0558@1|root,COG0558@2|Bacteria,46VZY@74201|Verrucomicrobia	74201|Verrucomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_7266772_31	481448.Minf_1881	9.426e-26	112.0	COG0314@1|root,COG0314@2|Bacteria,46T71@74201|Verrucomicrobia,37GVA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	MoaE protein	moaE	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HKD1_k127_7266772_3	235909.GK2344	1.39e-193	615.0	COG0362@1|root,COG0362@2|Bacteria,1TP4I@1239|Firmicutes,4H9NC@91061|Bacilli,1WEEJ@129337|Geobacillus	91061|Bacilli	G	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH	gnd	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD1_k127_7266772_30	497964.CfE428DRAFT_3426	3.549e-36	144.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_5
HKD1_k127_7266772_17	497964.CfE428DRAFT_1863	6.053e-70	246.0	COG0382@1|root,COG0382@2|Bacteria,46UH5@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_7266772_19	1185876.BN8_03503	4.38e-64	222.0	COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,47PQK@768503|Cytophagia	976|Bacteroidetes	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_7266772_12	497964.CfE428DRAFT_3540	1.871e-103	345.0	COG0484@1|root,COG0484@2|Bacteria,46S6P@74201|Verrucomicrobia	74201|Verrucomicrobia	O	DnaJ molecular chaperone homology domain	cbpA	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_7266772_34	1408303.JNJJ01000037_gene54	7.102e-15	77.0	2DNS1@1|root,32YVX@2|Bacteria,1VEGC@1239|Firmicutes,4HPC6@91061|Bacilli,1ZJ6M@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF2905)	yrzS	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD1_k127_7266772_18	497964.CfE428DRAFT_1671	2.075e-69	242.0	COG1573@1|root,COG1573@2|Bacteria,46V7R@74201|Verrucomicrobia	74201|Verrucomicrobia	L	PFAM Uracil-DNA glycosylase superfamily	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_7266772_1	497964.CfE428DRAFT_2384	9.481e-242	760.0	COG1164@1|root,COG1164@2|Bacteria,46UYD@74201|Verrucomicrobia	74201|Verrucomicrobia	E	PFAM peptidase M3A and M3B thimet oligopeptidase F	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD1_k127_7266772_9	1396418.BATQ01000171_gene2961	2.832e-105	354.0	COG1680@1|root,COG1680@2|Bacteria,46WBQ@74201|Verrucomicrobia,2ITZX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_7266772_25	1396141.BATP01000004_gene5893	6.411e-56	199.0	COG0432@1|root,COG0432@2|Bacteria,46V31@74201|Verrucomicrobia,2IUFK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_7266772_21	497964.CfE428DRAFT_6292	4.06e-60	213.0	COG0634@1|root,COG0634@2|Bacteria,46T02@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD1_k127_7266772_35	529709.PYCH_04490	1.521e-12	71.0	COG1977@1|root,arCOG00536@2157|Archaea,2XZ69@28890|Euryarchaeota,244I1@183968|Thermococci	183968|Thermococci	H	ThiS family	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_7266772_15	497964.CfE428DRAFT_2044	1.909e-83	285.0	COG1043@1|root,COG1043@2|Bacteria,46SQN@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	-	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_7266772_14	497964.CfE428DRAFT_2046	2.895e-92	308.0	COG2003@1|root,COG2003@2|Bacteria,46STQ@74201|Verrucomicrobia	74201|Verrucomicrobia	L	RadC-like JAB domain	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD1_k127_7266772_8	497964.CfE428DRAFT_2060	1.166e-106	357.0	COG0142@1|root,COG0142@2|Bacteria,46SKW@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_7266772_28	497964.CfE428DRAFT_1799	3.239e-41	162.0	COG0095@1|root,COG0095@2|Bacteria,46T01@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Biotin/lipoate A/B protein ligase family	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD1_k127_7266772_20	671143.DAMO_2553	1.35e-60	216.0	COG0284@1|root,COG0284@2|Bacteria,2NQYX@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0015949,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_1444,iECSF_1327.ECSF_1264,iSFV_1184.SFV_1294,iSF_1195.SF1285,iSFxv_1172.SFxv_1457,iS_1188.S1368,ic_1306.c1750	OMPdecase
HKD1_k127_7266772_13	497964.CfE428DRAFT_2922	6.055e-96	321.0	COG1947@1|root,COG1947@2|Bacteria,46SV6@74201|Verrucomicrobia	74201|Verrucomicrobia	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_7266772_10	1128421.JAGA01000003_gene2922	7.945e-105	347.0	COG0479@1|root,COG0479@2|Bacteria,2NPY8@2323|unclassified Bacteria	2|Bacteria	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240,ko:K00245	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_7,Fer4_8
HKD1_k127_7266772_26	497964.CfE428DRAFT_2242	1.52e-44	164.0	COG0399@1|root,COG0399@2|Bacteria,46T3Z@74201|Verrucomicrobia	74201|Verrucomicrobia	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_7266772_0	497964.CfE428DRAFT_3990	1.4e-322	996.0	COG1053@1|root,COG1053@2|Bacteria,46S7D@74201|Verrucomicrobia	74201|Verrucomicrobia	C	TIGRFAM succinate dehydrogenase or fumarate reductase, flavoprotein subunit	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_7266772_22	1408303.JNJJ01000009_gene2253	9.958e-60	213.0	COG0225@1|root,COG0225@2|Bacteria,1TQ3E@1239|Firmicutes,4HAIV@91061|Bacilli,1ZCC5@1386|Bacillus	91061|Bacilli	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD1_k127_7266772_27	497964.CfE428DRAFT_0169	1.27e-42	165.0	COG0220@1|root,COG0220@2|Bacteria,46T5A@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD1_k127_7266772_11	1403819.BATR01000087_gene2551	1.495e-104	368.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,46T3W@74201|Verrucomicrobia,2IUFR@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Competence protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD1_k127_7266772_32	290315.Clim_2314	2.056e-22	104.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
HKD1_k127_7266772_7	497964.CfE428DRAFT_0415	3.657e-143	465.0	COG2256@1|root,COG2256@2|Bacteria,46S7H@74201|Verrucomicrobia	74201|Verrucomicrobia	L	AAA ATPase central domain protein	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_7266772_2	497964.CfE428DRAFT_0254	7.683e-204	656.0	COG0166@1|root,COG0166@2|Bacteria,46SUH@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_7266772_29	497964.CfE428DRAFT_0255	7.63e-37	151.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	-	-	2.7.13.3	ko:K03406,ko:K07675,ko:K13598	ko02020,ko02030,map02020,map02030	M00473,M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,MCPsignal,PAS,PAS_4,PAS_9,dCache_1
HKD1_k127_7266772_4	497964.CfE428DRAFT_0256	1.31e-182	582.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	frgC	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GAF_2,HTH_8,Pkinase,Response_reg,Sigma54_activat
HKD1_k127_7266772_23	1403819.BATR01000102_gene3372	1.077e-57	202.0	COG0720@1|root,COG0720@2|Bacteria,46TAM@74201|Verrucomicrobia,2IVT3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	6-pyruvoyl tetrahydropterin synthase	-	-	-	-	-	-	-	-	-	-	-	-	PTPS
HKD1_k127_7266772_16	880073.Calab_2511	6.847e-83	282.0	COG0602@1|root,COG0602@2|Bacteria,2NPEM@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	1.97.1.4,4.3.99.3	ko:K04068,ko:K10026	ko00790,ko01100,map00790,map01100	-	R04710,R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_1658	Fer4_14,Radical_SAM
HKD1_k127_7266772_36	879212.DespoDRAFT_03364	1.873e-11	77.0	COG5338@1|root,COG5338@2|Bacteria,1QTI0@1224|Proteobacteria,42PG4@68525|delta/epsilon subdivisions,2WKB2@28221|Deltaproteobacteria,2MJF0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative beta-barrel porin 2	-	-	-	ko:K20920	ko05111,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.66.3.1,1.B.66.3.2	-	-	BBP2_2
HKD1_k127_7284390_3	237368.SCABRO_00352	8.288e-14	82.0	2AM5X@1|root,31C0B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7284390_1	378806.STAUR_6417	5.517e-76	265.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2YY1K@29|Myxococcales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
HKD1_k127_7284390_0	349741.Amuc_1774	1.499e-194	616.0	COG0423@1|root,COG0423@2|Bacteria,46TEV@74201|Verrucomicrobia,2ITMG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Anticodon binding domain	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD1_k127_7284390_2	1265503.KB905166_gene965	4.102e-25	106.0	COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,1S4EM@1236|Gammaproteobacteria,2Q82J@267889|Colwelliaceae	1236|Gammaproteobacteria	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_7398687_8	684719.HIMB114_00003360	4.986e-07	51.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TSN5@28211|Alphaproteobacteria,4BR7H@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	4Fe-4S dicluster domain	MA20_43170	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_8
HKD1_k127_7398687_6	497964.CfE428DRAFT_2227	7.053e-46	177.0	COG2010@1|root,COG2010@2|Bacteria,46T74@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_7398687_7	497964.CfE428DRAFT_2226	3.081e-43	170.0	COG2993@1|root,COG2993@2|Bacteria,46T1F@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM cytochrome C oxidase mono-heme subunit FixO	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD1_k127_7398687_2	1123508.JH636443_gene5055	1.205e-147	482.0	COG3278@1|root,COG3278@2|Bacteria,2IY0E@203682|Planctomycetes	203682|Planctomycetes	C	COGs COG3278 Cbb3-type cytochrome oxidase subunit 1	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HKD1_k127_7398687_3	497964.CfE428DRAFT_2222	9.288e-109	365.0	COG4531@1|root,COG4531@2|Bacteria,46SME@74201|Verrucomicrobia	74201|Verrucomicrobia	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7398687_5	497964.CfE428DRAFT_2221	5.189e-65	229.0	COG2010@1|root,COG2010@2|Bacteria,46SV4@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_7398687_4	497964.CfE428DRAFT_2220	4.059e-75	257.0	COG2010@1|root,COG2010@2|Bacteria,46VEQ@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD1_k127_7398687_0	497964.CfE428DRAFT_2219	5.038e-216	679.0	COG5557@1|root,COG5557@2|Bacteria,46S9S@74201|Verrucomicrobia	74201|Verrucomicrobia	C	PFAM Polysulphide reductase NrfD	-	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HKD1_k127_7398687_1	497964.CfE428DRAFT_2218	1.048e-192	618.0	COG0437@1|root,COG0437@2|Bacteria,46S66@74201|Verrucomicrobia	74201|Verrucomicrobia	C	4Fe-4S dicluster domain	hybA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
HKD1_k127_744429_20	243231.GSU1115	3.465e-08	61.0	COG1426@1|root,COG1426@2|Bacteria,1NN27@1224|Proteobacteria,42V2R@68525|delta/epsilon subdivisions,2WQP6@28221|Deltaproteobacteria,43V92@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD1_k127_744429_1	497964.CfE428DRAFT_2154	3.535e-255	814.0	COG1674@1|root,COG1674@2|Bacteria,46SCV@74201|Verrucomicrobia	74201|Verrucomicrobia	D	PFAM cell divisionFtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_744429_5	452637.Oter_1524	1.442e-153	499.0	COG3104@1|root,COG3104@2|Bacteria	2|Bacteria	E	oligopeptide transport	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD1_k127_744429_2	452637.Oter_4531	3.148e-203	647.0	COG4805@1|root,COG4805@2|Bacteria,46T5D@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_744429_8	497964.CfE428DRAFT_0886	4.245e-119	396.0	2EYW5@1|root,33S36@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_744429_14	497964.CfE428DRAFT_0885	3.315e-75	258.0	2F2ZI@1|root,33VUW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_744429_13	497964.CfE428DRAFT_0884	2.86e-75	263.0	COG2367@1|root,COG2367@2|Bacteria	2|Bacteria	V	Beta-lactamase	-	-	3.4.11.2,3.5.2.6	ko:K01256,ko:K17836	ko00311,ko00480,ko01100,ko01130,ko01501,map00311,map00480,map01100,map01130,map01501	M00627,M00628	R00899,R04951,R06363	RC00096,RC00141,RC01499	ko00000,ko00001,ko00002,ko01000,ko01002,ko01504	-	-	-	Beta-lactamase,Beta-lactamase2
HKD1_k127_744429_16	497964.CfE428DRAFT_6254	1.886e-67	237.0	COG2071@1|root,COG2071@2|Bacteria	2|Bacteria	S	gamma-glutamyl-gamma-aminobutyrate hydrolase activity	-	-	4.1.3.27	ko:K01658,ko:K07010	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	Peptidase_C26
HKD1_k127_744429_9	395961.Cyan7425_3554	6.775e-119	398.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K13021	-	-	-	-	ko00000,ko02000	2.A.1.14.3	-	-	MFS_1
HKD1_k127_744429_17	1380394.JADL01000004_gene5750	1.794e-65	226.0	COG3542@1|root,COG3542@2|Bacteria,1RAD7@1224|Proteobacteria,2U6RX@28211|Alphaproteobacteria,2JY7V@204441|Rhodospirillales	204441|Rhodospirillales	S	Cupin superfamily (DUF985)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_5
HKD1_k127_744429_22	663610.JQKO01000017_gene1661	0.0002274	44.0	COG3542@1|root,COG3542@2|Bacteria,1RAD7@1224|Proteobacteria,2U6RX@28211|Alphaproteobacteria,3NCDQ@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
HKD1_k127_744429_18	1403819.BATR01000181_gene6215	1.39e-47	176.0	COG0780@1|root,COG0780@2|Bacteria,46SYQ@74201|Verrucomicrobia,2IUI4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	QueF-like protein	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD1_k127_744429_12	1267535.KB906767_gene1566	1.63e-100	332.0	COG0603@1|root,COG0603@2|Bacteria,3Y3RP@57723|Acidobacteria,2JHPC@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD1_k127_744429_11	1340493.JNIF01000003_gene4412	3.5e-103	353.0	COG1167@1|root,COG1167@2|Bacteria,3Y3WK@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD1_k127_744429_15	478741.JAFS01000002_gene44	1.88e-67	241.0	COG0791@1|root,COG0791@2|Bacteria,46SVG@74201|Verrucomicrobia,37GHP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	NlpC/P60 family	spr	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD1_k127_744429_3	497964.CfE428DRAFT_0210	3.364e-188	597.0	COG0624@1|root,COG0624@2|Bacteria,46UH8@74201|Verrucomicrobia	74201|Verrucomicrobia	E	peptidase dimerisation domain protein	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_744429_10	861299.J421_4223	3.352e-107	362.0	COG0531@1|root,COG0531@2|Bacteria,1ZSZK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_744429_0	497964.CfE428DRAFT_4695	5.302e-289	928.0	COG1196@1|root,COG1196@2|Bacteria,46TT8@74201|Verrucomicrobia	74201|Verrucomicrobia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_744429_7	497964.CfE428DRAFT_6473	2.049e-126	413.0	COG1071@1|root,COG1071@2|Bacteria,46UAY@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Dehydrogenase E1 component	-	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_744429_4	497964.CfE428DRAFT_6472	5.958e-162	514.0	COG0022@1|root,COG0022@2|Bacteria,46UID@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_744429_6	497964.CfE428DRAFT_6471	2.801e-135	441.0	COG0508@1|root,COG0508@2|Bacteria,46UHU@74201|Verrucomicrobia	74201|Verrucomicrobia	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_7444671_9	497964.CfE428DRAFT_3647	3.089e-21	94.0	COG1236@1|root,COG1793@1|root,COG1236@2|Bacteria,COG1793@2|Bacteria,46SCR@74201|Verrucomicrobia	74201|Verrucomicrobia	L	DNA ligase N terminus	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K07577,ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N,RMMBL
HKD1_k127_7444671_3	497964.CfE428DRAFT_0887	2.794e-72	248.0	COG0204@1|root,COG0204@2|Bacteria,46SYR@74201|Verrucomicrobia	74201|Verrucomicrobia	I	PFAM phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_7444671_4	497964.CfE428DRAFT_0888	2.831e-65	230.0	COG0283@1|root,COG0283@2|Bacteria	2|Bacteria	F	belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015939,GO:0015940,GO:0015949,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0050896,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.17.7.4,2.5.1.19,2.7.1.26,2.7.4.25,2.7.7.2,6.3.2.1	ko:K00800,ko:K00945,ko:K02945,ko:K03527,ko:K03977,ko:K11753,ko:K13799	ko00240,ko00400,ko00410,ko00740,ko00770,ko00900,ko01100,ko01110,ko01130,ko01230,ko03010,map00240,map00400,map00410,map00740,map00770,map00900,map01100,map01110,map01130,map01230,map03010	M00022,M00052,M00096,M00119,M00125,M00178	R00158,R00161,R00512,R00549,R01665,R02473,R03460,R05884,R08210	RC00002,RC00017,RC00096,RC00141,RC00350,RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03009,ko03011	-	-	iPC815.YPO1391,iSDY_1059.SDY_2348	Cytidylate_kin
HKD1_k127_7444671_1	497964.CfE428DRAFT_0889	2.493e-171	548.0	COG0128@1|root,COG0128@2|Bacteria,46SFD@74201|Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin,EPSP_synthase
HKD1_k127_7444671_10	497964.CfE428DRAFT_0891	1.834e-13	76.0	2DBSP@1|root,2ZAT9@2|Bacteria,46TYZ@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7444671_2	497964.CfE428DRAFT_2381	1.541e-90	312.0	COG2208@1|root,COG3437@1|root,COG2208@2|Bacteria,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	-	-	3.1.3.3	ko:K07315,ko:K20977	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko03021	-	-	-	HATPase_c,HATPase_c_2,HisKA,Response_reg,SpoIIE
HKD1_k127_7444671_7	278957.ABEA03000195_gene469	2.202e-31	124.0	COG5531@1|root,COG5531@2|Bacteria,46T1X@74201|Verrucomicrobia,3K8F3@414999|Opitutae	414999|Opitutae	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HKD1_k127_7444671_5	481448.Minf_0355	7.686e-42	159.0	COG0526@1|root,COG0526@2|Bacteria,46SXQ@74201|Verrucomicrobia,37GRV@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	CO	Protein of unknown function, DUF255	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_2,Thioredoxin_7
HKD1_k127_7444671_8	497964.CfE428DRAFT_2283	9.519e-31	126.0	COG2331@1|root,COG2331@2|Bacteria,46T2S@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_7444671_6	1408473.JHXO01000012_gene336	3.812e-37	147.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950,ko:K09163	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_7444671_0	945713.IALB_1150	2.344e-236	747.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.33,4.2.1.35,4.2.1.36	ko:K01703,ko:K01704,ko:K01705	ko00290,ko00300,ko00660,ko00966,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00290,map00300,map00660,map00966,map01100,map01110,map01120,map01130,map01210,map01230	M00030,M00432,M00433,M00535	R03896,R03898,R03968,R04001,R04371,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00618,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_7444671_11	1047013.AQSP01000140_gene2452	2.438e-06	49.0	COG0473@1|root,COG0473@2|Bacteria,2NNUM@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	dlpA	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh,MoCF_biosynth,RraA-like
HKD1_k127_7598163_0	886293.Sinac_0736	1.172e-136	459.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,2IYAH@203682|Planctomycetes	203682|Planctomycetes	C	FAD linked oxidases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_8
HKD1_k127_7598163_1	583355.Caka_1506	1.97e-105	350.0	COG0389@1|root,COG0389@2|Bacteria,46SNK@74201|Verrucomicrobia,3K7SQ@414999|Opitutae	414999|Opitutae	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_7681550_2	1267533.KB906733_gene3362	4.081e-41	162.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y7E7@57723|Acidobacteria,2JKGS@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_7681550_0	1379698.RBG1_1C00001G0607	8.222e-107	372.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_7681550_4	1267534.KB906754_gene3732	6.458e-35	143.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7681550_1	1356852.N008_11935	2.381e-75	261.0	arCOG09511@1|root,2Z9DH@2|Bacteria,4NIMU@976|Bacteroidetes,47N8K@768503|Cytophagia	976|Bacteroidetes	S	FRG	-	-	-	-	-	-	-	-	-	-	-	-	FRG
HKD1_k127_7681550_3	1122604.JONR01000004_gene853	3.546e-38	149.0	COG5616@1|root,COG5616@2|Bacteria,1NSKC@1224|Proteobacteria,1T49A@1236|Gammaproteobacteria,1XDC3@135614|Xanthomonadales	135614|Xanthomonadales	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7717246_14	497964.CfE428DRAFT_2915	4.186e-38	145.0	COG0541@1|root,COG0541@2|Bacteria,46SIU@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_7717246_7	497964.CfE428DRAFT_2916	8.894e-102	346.0	COG0726@1|root,COG0726@2|Bacteria,46UVJ@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_7717246_11	497964.CfE428DRAFT_4528	6.085e-50	185.0	COG0860@1|root,COG0860@2|Bacteria,46VPU@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Ami_3	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3
HKD1_k127_7717246_3	216596.RL2938	4.314e-136	445.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2U1T7@28211|Alphaproteobacteria,4BAS5@82115|Rhizobiaceae	28211|Alphaproteobacteria	EGP	Sugar (and other) transporter	-	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1,Sugar_tr
HKD1_k127_7717246_13	1123399.AQVE01000011_gene1258	1.062e-39	161.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD1_k127_7717246_9	497964.CfE428DRAFT_5268	5.666e-71	251.0	COG1560@1|root,COG1560@2|Bacteria,46VIS@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
HKD1_k127_7717246_10	497964.CfE428DRAFT_2318	2.264e-59	216.0	COG0664@1|root,COG4420@1|root,COG0664@2|Bacteria,COG4420@2|Bacteria,46T5T@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003,cNMP_binding
HKD1_k127_7717246_1	478741.JAFS01000001_gene2175	9.282e-206	656.0	COG0112@1|root,COG0112@2|Bacteria,46S5I@74201|Verrucomicrobia,37G4S@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	LMWPc,LacAB_rpiB,SHMT
HKD1_k127_7717246_0	497964.CfE428DRAFT_3605	1.511e-240	752.0	COG0364@1|root,COG0364@2|Bacteria,46SHX@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD1_k127_7717246_8	497964.CfE428DRAFT_3604	5.137e-75	266.0	COG3429@1|root,COG3429@2|Bacteria,46V8B@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Glucose-6-phosphate dehydrogenase subunit	-	-	-	-	-	-	-	-	-	-	-	-	OpcA_G6PD_assem
HKD1_k127_7717246_6	1403819.BATR01000061_gene1891	2.467e-102	347.0	COG0438@1|root,COG0438@2|Bacteria,46WHJ@74201|Verrucomicrobia,2IVEA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_7717246_12	1123229.AUBC01000001_gene1591	2.233e-40	154.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,3JY0X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD1_k127_7717246_5	497964.CfE428DRAFT_6301	1.17e-121	401.0	COG0809@1|root,COG0809@2|Bacteria,46SDA@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD1_k127_7717246_4	266117.Rxyl_3138	4.305e-133	433.0	COG1533@1|root,COG1533@2|Bacteria,2GM31@201174|Actinobacteria,4CQAG@84995|Rubrobacteria	84995|Rubrobacteria	L	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_7717246_2	204669.Acid345_0995	6.72e-150	478.0	COG3191@1|root,COG3191@2|Bacteria,3Y699@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD1_k127_7732192_1	196490.AUEZ01000066_gene2437	6.554e-130	420.0	COG2267@1|root,COG2267@2|Bacteria,1QU7J@1224|Proteobacteria,2TX2K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Secretory lipase	-	-	-	-	-	-	-	-	-	-	-	-	LIP
HKD1_k127_7732192_3	497964.CfE428DRAFT_0947	2.686e-49	183.0	COG2834@1|root,COG2834@2|Bacteria	2|Bacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA,LolA_like
HKD1_k127_7732192_7	1380394.JADL01000005_gene5547	7.094e-11	67.0	COG0433@1|root,COG0433@2|Bacteria,1QXYS@1224|Proteobacteria,2UHW9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
HKD1_k127_7732192_5	497964.CfE428DRAFT_6335	6.734e-27	115.0	COG0319@1|root,COG0319@2|Bacteria,46WBN@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD1_k127_7732192_4	497964.CfE428DRAFT_6333	4.865e-35	137.0	COG2127@1|root,COG2127@2|Bacteria,46T8N@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD1_k127_7732192_2	497964.CfE428DRAFT_2380	5.386e-54	198.0	COG1595@1|root,COG1595@2|Bacteria,46VRK@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_7732192_0	497964.CfE428DRAFT_1957	1.536e-297	921.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,46SCZ@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HKD1_k127_7741424_0	497964.CfE428DRAFT_2218	1.043e-168	545.0	COG0437@1|root,COG0437@2|Bacteria,46S66@74201|Verrucomicrobia	74201|Verrucomicrobia	C	4Fe-4S dicluster domain	hybA	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
HKD1_k127_7741424_1	497964.CfE428DRAFT_2217	5.157e-110	360.0	COG3880@1|root,COG3880@2|Bacteria,46SMN@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_7741424_5	497964.CfE428DRAFT_4975	8.285e-64	232.0	COG0354@1|root,COG0354@2|Bacteria,46T24@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD1_k127_7741424_4	497964.CfE428DRAFT_4974	9.978e-75	264.0	COG2084@1|root,COG2084@2|Bacteria,46U4D@74201|Verrucomicrobia	74201|Verrucomicrobia	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_7741424_3	497964.CfE428DRAFT_1801	4.814e-86	295.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	ywaD	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_7741424_2	497964.CfE428DRAFT_1800	4.496e-102	340.0	COG1475@1|root,COG1475@2|Bacteria,46SQ8@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_7741424_7	204669.Acid345_0352	5.257e-13	81.0	COG0729@1|root,COG5295@1|root,COG0729@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	yeeJ	-	-	ko:K07278,ko:K21449	-	-	-	-	ko00000,ko02000	1.B.33.2.4,1.B.40.2	-	-	DUF5122,Peptidase_S74,YadA_head,YadA_stalk
HKD1_k127_7741424_6	1123248.KB893336_gene2839	2.433e-18	98.0	COG5295@1|root,COG5295@2|Bacteria,4NJTK@976|Bacteroidetes,1IVP5@117747|Sphingobacteriia	976|Bacteroidetes	UW	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,YadA_head
HKD1_k127_7877750_2	1123073.KB899242_gene1321	1.664e-125	409.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,1RZSZ@1236|Gammaproteobacteria,1XA6G@135614|Xanthomonadales	135614|Xanthomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7877750_6	1396141.BATP01000040_gene2174	2.623e-42	166.0	COG3315@1|root,COG3315@2|Bacteria	2|Bacteria	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM,Methyltransf_19
HKD1_k127_7877750_0	1408445.JHXP01000014_gene1418	6.217e-143	468.0	COG0277@1|root,COG0277@2|Bacteria,1MV1Q@1224|Proteobacteria,1RSC3@1236|Gammaproteobacteria,1JDAH@118969|Legionellales	118969|Legionellales	C	D-arabinono-1,4-lactone oxidase	-	-	-	-	-	-	-	-	-	-	-	-	ALO,FAD_binding_4
HKD1_k127_7877750_1	452637.Oter_2782	4.235e-133	436.0	COG0501@1|root,COG0501@2|Bacteria,46TVV@74201|Verrucomicrobia,3K72R@414999|Opitutae	414999|Opitutae	O	Peptidase M48	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD1_k127_7877750_4	485913.Krac_3074	1.919e-114	381.0	COG0665@1|root,COG0665@2|Bacteria,2G6XM@200795|Chloroflexi	200795|Chloroflexi	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00301	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_7877750_5	497964.CfE428DRAFT_1418	4.125e-53	192.0	COG1847@1|root,COG1847@2|Bacteria,46VYD@74201|Verrucomicrobia	74201|Verrucomicrobia	S	R3H domain	-	-	-	-	-	-	-	-	-	-	-	-	R3H
HKD1_k127_7877750_3	497964.CfE428DRAFT_1419	5.037e-118	400.0	COG0706@1|root,COG0706@2|Bacteria,46SHI@74201|Verrucomicrobia	74201|Verrucomicrobia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD1_k127_7877750_7	1396418.BATQ01000150_gene2227	7.349e-26	109.0	COG0759@1|root,COG0759@2|Bacteria,46W3D@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD1_k127_7877750_8	497964.CfE428DRAFT_1421	2.27e-16	81.0	COG0594@1|root,COG0594@2|Bacteria,46WEU@74201|Verrucomicrobia	74201|Verrucomicrobia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	-	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_789757_11	497964.CfE428DRAFT_5417	1.117e-19	92.0	COG0330@1|root,COG0330@2|Bacteria,46SQ6@74201|Verrucomicrobia	74201|Verrucomicrobia	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_789757_0	497964.CfE428DRAFT_5043	1.222e-171	552.0	COG2079@1|root,COG2079@2|Bacteria,46VQ9@74201|Verrucomicrobia	74201|Verrucomicrobia	S	MmgE/PrpD family	prpD	-	4.2.1.79	ko:K01720	ko00640,map00640	-	R04424	RC01152	ko00000,ko00001,ko01000	-	-	-	MmgE_PrpD
HKD1_k127_789757_3	497964.CfE428DRAFT_5044	9.903e-106	351.0	COG2513@1|root,COG2513@2|Bacteria	2|Bacteria	G	methylisocitrate lyase activity	prpB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006091,GO:0006113,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0015980,GO:0016042,GO:0016054,GO:0016829,GO:0016830,GO:0016833,GO:0016999,GO:0017001,GO:0017144,GO:0019541,GO:0019543,GO:0019626,GO:0019629,GO:0019752,GO:0032787,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0046421,GO:0046459,GO:0046872,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	iECNA114_1301.ECNA114_0319,iECP_1309.ECP_0407	PEP_mutase
HKD1_k127_789757_1	497964.CfE428DRAFT_5045	1.227e-164	526.0	COG0372@1|root,COG0372@2|Bacteria,46SBV@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_789757_6	215803.DB30_0292	2.137e-66	231.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_789757_5	1122604.JONR01000003_gene1527	5.401e-89	303.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,1RWGW@1236|Gammaproteobacteria,1X55V@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HKD1_k127_789757_10	103733.JNYO01000024_gene9146	1.048e-21	100.0	29PQU@1|root,30AP1@2|Bacteria,2IFHX@201174|Actinobacteria,4E5SZ@85010|Pseudonocardiales	201174|Actinobacteria	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HKD1_k127_789757_2	1038922.PflQ2_2171	8.867e-108	359.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,1RPR3@1236|Gammaproteobacteria,1YNZM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	FL	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HKD1_k127_789757_13	33876.JNXY01000004_gene1576	5.396e-16	93.0	COG1404@1|root,COG3055@1|root,COG1404@2|Bacteria,COG3055@2|Bacteria,2HU5X@201174|Actinobacteria,4DBT0@85008|Micromonosporales	201174|Actinobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Cleaved_Adhesin,Kelch_1,Peptidase_S8
HKD1_k127_789757_9	1123508.JH636450_gene7219	3.805e-33	150.0	COG1404@1|root,COG2911@1|root,COG2931@1|root,COG3210@1|root,COG3391@1|root,COG4935@1|root,COG1404@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3391@2|Bacteria,COG4935@2|Bacteria,2IZWN@203682|Planctomycetes	203682|Planctomycetes	Q	HemY domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_789757_14	1112216.JH594434_gene43	1.309e-11	66.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_789757_8	335543.Sfum_0885	3.4e-43	173.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD1_k127_789757_12	945713.IALB_0186	5.238e-16	85.0	COG4675@1|root,COG5276@1|root,COG4675@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	M	tail collar domain protein	-	-	3.4.24.40	ko:K01406,ko:K21449	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002,ko02000	1.B.40.2	-	-	Collar,Phage_fiber_2
HKD1_k127_789757_15	1267534.KB906754_gene2771	6.412e-07	57.0	COG3115@1|root,COG3115@2|Bacteria,3Y82I@57723|Acidobacteria,2JN9R@204432|Acidobacteriia	204432|Acidobacteriia	D	Protein of unknown function (DUF3761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3761
HKD1_k127_789757_4	861299.J421_0392	5.67e-101	342.0	COG1301@1|root,COG1301@2|Bacteria,1ZTDM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Sodium:dicarboxylate symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD1_k127_789757_7	1089544.KB912942_gene4292	1.112e-55	203.0	COG1028@1|root,COG1028@2|Bacteria,2GIX2@201174|Actinobacteria	201174|Actinobacteria	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_8004211_5	383372.Rcas_1424	9.965e-07	56.0	COG0594@1|root,COG0594@2|Bacteria,2G76W@200795|Chloroflexi,375ZH@32061|Chloroflexia	32061|Chloroflexia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_8004211_1	240016.ABIZ01000001_gene5947	1.042e-164	525.0	COG0686@1|root,COG0686@2|Bacteria,46S7U@74201|Verrucomicrobia,2ITXS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Alanine dehydrogenase/PNT, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_8004211_2	497964.CfE428DRAFT_0656	2.214e-48	180.0	COG1678@1|root,COG1678@2|Bacteria,46VUF@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Uncharacterized ACR, COG1678	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD1_k127_8004211_4	1519464.HY22_14065	4.372e-14	81.0	2DDRS@1|root,2ZJ0Y@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
HKD1_k127_8004211_0	497964.CfE428DRAFT_1548	2.218e-250	792.0	COG0587@1|root,COG0587@2|Bacteria,46SG0@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_8019673_4	1396418.BATQ01000046_gene6169	1.386e-177	569.0	COG0764@1|root,COG0774@1|root,COG0764@2|Bacteria,COG0774@2|Bacteria,46SG1@74201|Verrucomicrobia,2ITYH@203494|Verrucomicrobiae	203494|Verrucomicrobiae	IM	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	fabZ	-	3.5.1.108,4.2.1.59	ko:K16363	ko00061,ko00540,ko01100,ko01212,map00061,map00540,map01100,map01212	M00060,M00083	R04428,R04535,R04537,R04544,R04568,R04587,R04954,R04965	RC00166,RC00300,RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004,ko01005	-	-	-	FabA,LpxC
HKD1_k127_8019673_2	497964.CfE428DRAFT_2513	7.487e-203	644.0	COG1543@1|root,COG1543@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K03406,ko:K16149	ko00500,ko01100,ko01110,ko02020,ko02030,map00500,map01100,map01110,map02020,map02030	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko02035	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_transf_4,Glycos_transf_1
HKD1_k127_8019673_3	497964.CfE428DRAFT_2463	2.499e-191	603.0	COG0436@1|root,COG0436@2|Bacteria,46S4M@74201|Verrucomicrobia	74201|Verrucomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_8019673_8	497964.CfE428DRAFT_2462	1.307e-154	495.0	COG0105@1|root,COG0105@2|Bacteria,46T8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Nucleoside diphosphate kinase	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_8019673_29	1122604.JONR01000016_gene4379	3.874e-13	78.0	2EIJE@1|root,33CAQ@2|Bacteria,1PVJ0@1224|Proteobacteria,1RWAX@1236|Gammaproteobacteria,1XBGS@135614|Xanthomonadales	135614|Xanthomonadales	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8019673_22	452637.Oter_2569	7.222e-44	166.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	algT	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_8019673_17	1403819.BATR01000137_gene4884	6.93e-88	300.0	COG0196@1|root,COG0196@2|Bacteria,46SZ6@74201|Verrucomicrobia,2IU48@203494|Verrucomicrobiae	203494|Verrucomicrobiae	H	Riboflavin kinase	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_8019673_14	497964.CfE428DRAFT_1793	3.917e-100	335.0	COG0130@1|root,COG0130@2|Bacteria,46SJR@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HKD1_k127_8019673_12	497964.CfE428DRAFT_1792	5.835e-113	374.0	COG0618@1|root,COG0618@2|Bacteria,46T03@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM phosphoesterase RecJ domain protein	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_8019673_26	497964.CfE428DRAFT_1791	9.103e-28	117.0	COG0858@1|root,COG0858@2|Bacteria,46TBI@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD1_k127_8019673_1	497964.CfE428DRAFT_1790	2.307e-271	854.0	COG0532@1|root,COG0532@2|Bacteria,46S8V@74201|Verrucomicrobia	74201|Verrucomicrobia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD1_k127_8019673_5	497964.CfE428DRAFT_1789	3.17e-176	561.0	COG0195@1|root,COG0195@2|Bacteria,46TRP@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HKD1_k127_8019673_19	1403819.BATR01000124_gene4416	1.879e-68	254.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_8019673_24	1123368.AUIS01000018_gene731	1.651e-35	141.0	COG1846@1|root,COG1846@2|Bacteria,1PC0Q@1224|Proteobacteria,1SXNR@1236|Gammaproteobacteria,2NDAB@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Transcriptional regulator, MarR	-	-	-	ko:K06075	-	-	-	-	ko00000,ko03000	-	-	-	MarR_2
HKD1_k127_8019673_15	706587.Desti_1031	2.205e-89	310.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585,ko:K07799	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00646,M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6	-	-	HlyD_D23
HKD1_k127_8019673_0	706587.Desti_1032	0.0	1179.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_8019673_9	395965.Msil_2439	6.033e-145	467.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,3NA6C@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_8019673_21	1123399.AQVE01000011_gene1258	4.257e-56	217.0	COG3209@1|root,COG5295@1|root,COG3209@2|Bacteria,COG5295@2|Bacteria,1N4WT@1224|Proteobacteria	1224|Proteobacteria	UW	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74
HKD1_k127_8019673_20	1183438.GKIL_0413	7.349e-61	226.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD1_k127_8019673_7	497964.CfE428DRAFT_2241	2.02e-158	511.0	COG2805@1|root,COG2805@2|Bacteria,46SY2@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	PFAM type II secretion system protein E	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD1_k127_8019673_6	497964.CfE428DRAFT_2243	1.027e-158	507.0	COG2805@1|root,COG2805@2|Bacteria,46UF2@74201|Verrucomicrobia	74201|Verrucomicrobia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_8019673_28	497964.CfE428DRAFT_2246	1.358e-14	78.0	28ZM8@1|root,2ZMCH@2|Bacteria,46WY7@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Bacterial protein of unknown function (DUF883)	-	-	-	-	-	-	-	-	-	-	-	-	DUF883
HKD1_k127_8019673_25	497964.CfE428DRAFT_2247	4.03e-30	120.0	COG0361@1|root,COG0361@2|Bacteria	2|Bacteria	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_8019673_10	670307.HYPDE_33213	1.733e-140	469.0	COG3011@1|root,COG3011@2|Bacteria,1N0MB@1224|Proteobacteria	1224|Proteobacteria	S	Lipase maturation factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF393,LMF1
HKD1_k127_8019673_16	1242864.D187_008763	7.923e-89	300.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42R8B@68525|delta/epsilon subdivisions,2X5KI@28221|Deltaproteobacteria,2YUUJ@29|Myxococcales	28221|Deltaproteobacteria	L	Endonuclease/Exonuclease/phosphatase family	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD1_k127_8019673_11	1403819.BATR01000005_gene158	1.068e-133	441.0	COG1236@1|root,COG1236@2|Bacteria,46SQ0@74201|Verrucomicrobia,2ITW2@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Beta-Casp domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HKD1_k127_8019673_23	595460.RRSWK_04758	6.182e-37	144.0	2E5WH@1|root,32RS6@2|Bacteria	2|Bacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_8019673_18	1209989.TepiRe1_2193	2.31e-74	262.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,42F00@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_8019673_13	243231.GSU0371	4.65e-102	342.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,43T5A@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_845171_3	272568.GDI3615	1.756e-06	53.0	2EDVQ@1|root,33IT7@2|Bacteria,1NMMH@1224|Proteobacteria,2UMR0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_845171_2	311403.Arad_1164	7.689e-10	67.0	2AJ26@1|root,319KG@2|Bacteria,1Q32C@1224|Proteobacteria,2VA4A@28211|Alphaproteobacteria,4BFA9@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_845171_1	1304878.AUGD01000007_gene5472	7.52e-64	224.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TU76@28211|Alphaproteobacteria,3JTYJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	MA20_07455	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_845171_0	1040989.AWZU01000052_gene2512	1.177e-143	463.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,3JSVN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_855924_1	497964.CfE428DRAFT_5659	1.075e-122	404.0	COG2271@1|root,COG2271@2|Bacteria,46TP4@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_855924_0	497964.CfE428DRAFT_5656	5.257e-282	884.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,46SG3@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	PFAM AMP-dependent synthetase and ligase	caiC	-	2.3.1.40,6.2.1.20	ko:K05939	ko00071,ko00564,map00071,map00564	-	R01406,R04864	RC00014,RC00039,RC00041	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C,Acyltransferase
HKD1_k127_855924_3	1219031.BBJR01000040_gene2707	2.674e-51	194.0	COG3768@1|root,COG3768@2|Bacteria,1NNZU@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function (DUF697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF697
HKD1_k127_855924_4	1380347.JNII01000008_gene4314	4.417e-17	84.0	2C6EM@1|root,2ZFYQ@2|Bacteria,2GXX8@201174|Actinobacteria	201174|Actinobacteria	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD1_k127_855924_2	1192034.CAP_6066	1.128e-96	327.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria	1224|Proteobacteria	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_855924_5	1168034.FH5T_17160	3.569e-05	48.0	COG1396@1|root,COG1917@1|root,COG1396@2|Bacteria,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	puuR	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3,HTH_31
HKD1_k127_882345_5	671143.DAMO_0983	3.857e-19	94.0	COG0589@1|root,COG0589@2|Bacteria,2NPUM@2323|unclassified Bacteria	2|Bacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_882345_2	76114.ebA2870	1.768e-72	252.0	COG1073@1|root,COG1073@2|Bacteria,1RDAY@1224|Proteobacteria,2VQGW@28216|Betaproteobacteria	28216|Betaproteobacteria	S	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	DLH,Pribosyltran
HKD1_k127_882345_3	886293.Sinac_3851	7.608e-63	223.0	COG1926@1|root,COG1926@2|Bacteria,2J36S@203682|Planctomycetes	203682|Planctomycetes	F	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_882345_0	1121405.dsmv_0979	2.785e-285	885.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,42MHP@68525|delta/epsilon subdivisions,2WIQG@28221|Deltaproteobacteria,2MJ8G@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_882345_1	1121405.dsmv_0978	6.083e-144	463.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,42MHF@68525|delta/epsilon subdivisions,2WJ1R@28221|Deltaproteobacteria,2MMYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_882345_4	1121405.dsmv_0977	7.684e-29	117.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,42MBM@68525|delta/epsilon subdivisions,2WJKG@28221|Deltaproteobacteria,2MMK7@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Transketolase, pyrimidine binding domain	pdhB	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2753	Transket_pyr,Transketolase_C
HKD1_k127_882372_2	404589.Anae109_4069	0.0007497	46.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WRFB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_882372_1	330214.NIDE1927	1.616e-33	143.0	COG0589@1|root,COG0589@2|Bacteria,3J1A7@40117|Nitrospirae	40117|Nitrospirae	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_882372_0	118163.Ple7327_0398	4.632e-66	233.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,3VJI1@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_97479_11	497964.CfE428DRAFT_3303	1.696e-25	107.0	COG0504@1|root,COG0504@2|Bacteria,46S8K@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD1_k127_97479_7	240016.ABIZ01000001_gene5173	1.005e-95	324.0	COG0009@1|root,COG0009@2|Bacteria,46SUC@74201|Verrucomicrobia,2ITRQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD1_k127_97479_8	497964.CfE428DRAFT_4023	1.601e-59	210.0	COG0041@1|root,COG0041@2|Bacteria,46SRV@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_97479_10	1396418.BATQ01000171_gene2946	5.642e-37	146.0	COG0451@1|root,COG0703@1|root,COG0451@2|Bacteria,COG0703@2|Bacteria,46SWG@74201|Verrucomicrobia,2IUD4@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,SKI
HKD1_k127_97479_3	497964.CfE428DRAFT_4021	2.598e-139	451.0	COG1600@1|root,COG1600@2|Bacteria,46SDV@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Domain of unknown function (DUF1730)	-	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD1_k127_97479_5	452637.Oter_1637	8.987e-130	428.0	COG0845@1|root,COG0845@2|Bacteria,46SKN@74201|Verrucomicrobia,3K76J@414999|Opitutae	414999|Opitutae	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_97479_12	880072.Desac_2180	6.612e-14	76.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2WRUT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_97479_6	278957.ABEA03000126_gene3673	2.955e-108	355.0	COG1136@1|root,COG1136@2|Bacteria,46SI5@74201|Verrucomicrobia,3K7NZ@414999|Opitutae	414999|Opitutae	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_97479_0	1519464.HY22_00710	6.232e-168	537.0	COG0577@1|root,COG0577@2|Bacteria,1FDSK@1090|Chlorobi	1090|Chlorobi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_97479_1	1519464.HY22_00720	3.169e-158	509.0	COG0577@1|root,COG0577@2|Bacteria,1FDBN@1090|Chlorobi	1090|Chlorobi	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_97479_2	497964.CfE428DRAFT_4774	1.063e-145	468.0	COG0714@1|root,COG0714@2|Bacteria,46SKP@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM ATPase associated with various cellular activities AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_97479_9	497964.CfE428DRAFT_4775	1.101e-55	206.0	COG1721@1|root,COG1721@2|Bacteria	2|Bacteria	E	protein (some members contain a von Willebrand factor type A (vWA) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_97479_4	497964.CfE428DRAFT_4776	1.973e-136	458.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	tgpA	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
## 2411 queries scanned
## Total time (seconds): 174.30646061897278
## Rate: 13.83 q/s