## Wed Oct 16 20:29:00 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/HKD1_bin.73.fa -m mmseqs --itype genome -o HKD1_bin.73 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/HKD1_bin.73 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1005977_0	1540257.JQMW01000011_gene1838	2.091e-131	433.0	COG0624@1|root,COG0624@2|Bacteria,1TPEG@1239|Firmicutes,247SK@186801|Clostridia,36DX8@31979|Clostridiaceae	186801|Clostridia	E	Dipeptidase	ytjP	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_1005977_3	868131.MSWAN_0246	1.863e-19	92.0	COG1714@1|root,arCOG01917@1|root,arCOG01917@2157|Archaea,arCOG03633@2157|Archaea,2Y0FR@28890|Euryarchaeota	28890|Euryarchaeota	S	membrane protein domain	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_1005977_5	431943.CKL_0584	3.602e-14	79.0	COG2020@1|root,COG2020@2|Bacteria,1V495@1239|Firmicutes,24IHG@186801|Clostridia,36FBJ@31979|Clostridiaceae	186801|Clostridia	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_1005977_4	357808.RoseRS_3707	5.165e-17	84.0	COG2020@1|root,COG2020@2|Bacteria,2G9T5@200795|Chloroflexi,3761T@32061|Chloroflexia	32061|Chloroflexia	O	PFAM Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_1005977_1	1121405.dsmv_0026	1.577e-74	254.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2MJZR@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_1005977_2	1499683.CCFF01000013_gene341	3.473e-26	117.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,36GSV@31979|Clostridiaceae	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_103303_19	926549.KI421517_gene2414	2.031e-18	94.0	COG4758@1|root,COG4758@2|Bacteria	2|Bacteria	KT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2154,Toast_rack_N
HKD1_k127_103303_8	439481.Aboo_0474	8.314e-70	242.0	COG1059@1|root,arCOG04357@2157|Archaea,2XWSZ@28890|Euryarchaeota,3F2WU@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_103303_26	1227495.C487_17015	0.0007058	43.0	arCOG14112@1|root,arCOG14112@2157|Archaea,2Y0BR@28890|Euryarchaeota,23XT7@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_103303_2	192952.MM_2463	8.491e-228	720.0	COG0532@1|root,arCOG01560@2157|Archaea,2XU09@28890|Euryarchaeota,2N96H@224756|Methanomicrobia	224756|Methanomicrobia	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D4,IF-2
HKD1_k127_103303_11	572546.Arcpr_0498	1.593e-57	207.0	COG0105@1|root,arCOG04313@2157|Archaea,2XWSK@28890|Euryarchaeota,2465T@183980|Archaeoglobi	183980|Archaeoglobi	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_103303_18	593750.Metfor_2523	9.532e-19	86.0	COG2075@1|root,arCOG01950@2157|Archaea,2Y00Q@28890|Euryarchaeota,2NA03@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
HKD1_k127_103303_15	304371.MCP_1040	1.859e-31	123.0	COG2053@1|root,arCOG04314@2157|Archaea,2XYMV@28890|Euryarchaeota,2N9ZH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
HKD1_k127_103303_14	304371.MCP_1041	5.594e-48	174.0	COG1358@1|root,arCOG01751@2157|Archaea,2XX4C@28890|Euryarchaeota,2N9WX@224756|Methanomicrobia	224756|Methanomicrobia	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
HKD1_k127_103303_23	1094980.Mpsy_2864	2.58e-08	64.0	arCOG04912@1|root,arCOG04912@2157|Archaea,2Y3SP@28890|Euryarchaeota,2NAWD@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_103303_5	1094980.Mpsy_0405	3.233e-125	417.0	COG0294@1|root,arCOG01978@2157|Archaea,2XTEW@28890|Euryarchaeota,2N967@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	-	-	-	-	-	-	-	-	-	-	DUF4346,Pterin_bind
HKD1_k127_103303_16	269797.Mbar_A1085	1.995e-25	111.0	COG1935@1|root,arCOG04420@2157|Archaea,2Y1FM@28890|Euryarchaeota,2NA37@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF473)	-	-	-	ko:K09135	-	-	-	-	ko00000	-	-	-	DUF473
HKD1_k127_103303_7	1094980.Mpsy_1456	5.376e-70	246.0	COG1938@1|root,arCOG00347@2157|Archaea,2XT93@28890|Euryarchaeota,2N9KT@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
HKD1_k127_103303_0	909663.KI867150_gene90	9.464e-255	803.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,1MW98@1224|Proteobacteria,42NTV@68525|delta/epsilon subdivisions,2WJTP@28221|Deltaproteobacteria,2MQS6@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD1_k127_103303_17	1487953.JMKF01000045_gene2892	1.715e-22	109.0	COG1413@1|root,COG5635@1|root,COG1413@2|Bacteria,COG5635@2|Bacteria,1G233@1117|Cyanobacteria,1H7RE@1150|Oscillatoriales	1117|Cyanobacteria	C	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS,Metallophos,NACHT,Trypsin_2
HKD1_k127_103303_9	880072.Desac_0135	6.438e-68	235.0	COG1793@1|root,COG1793@2|Bacteria,1NTIR@1224|Proteobacteria,43022@68525|delta/epsilon subdivisions,2WV7R@28221|Deltaproteobacteria,2MRWD@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DNA polymerase Ligase (LigD)	-	-	-	-	-	-	-	-	-	-	-	-	LigD_N
HKD1_k127_103303_24	304371.MCP_2657	4.719e-07	53.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
HKD1_k127_103303_21	351160.RCIX1548	4.115e-12	67.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota,2N98H@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
HKD1_k127_103303_25	693661.Arcve_1482	5.619e-07	53.0	COG0301@1|root,arCOG00038@2157|Archaea,2XUHM@28890|Euryarchaeota	28890|Euryarchaeota	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
HKD1_k127_103303_22	565033.GACE_0113	5.849e-12	67.0	arCOG04481@1|root,arCOG04481@2157|Archaea,2Y0HE@28890|Euryarchaeota,246H8@183980|Archaeoglobi	183980|Archaeoglobi	S	Family of unknown function (DUF5350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5350
HKD1_k127_103303_12	351160.RCIX890	9.099e-50	191.0	COG0392@1|root,arCOG00899@2157|Archaea	2157|Archaea	Q	integral membrane protein	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD1_k127_103303_6	1041930.Mtc_1777	1.958e-73	259.0	arCOG01220@1|root,arCOG01220@2157|Archaea,2XYGI@28890|Euryarchaeota,2N9S5@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
HKD1_k127_103303_4	1158318.ATXC01000001_gene942	2.651e-150	486.0	COG0045@1|root,COG0045@2|Bacteria,2G3VC@200783|Aquificae	200783|Aquificae	C	ATP citrate lyase citrate-binding	-	-	2.3.3.8	ko:K15231	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00720,map01100,map01110,map01120,map01130,map01200	M00173	R00352	RC00004,RC00067	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Citrate_bind
HKD1_k127_103303_1	8090.ENSORLP00000017406	2.939e-230	729.0	COG0045@1|root,KOG1254@2759|Eukaryota,38CW6@33154|Opisthokonta,3BBF9@33208|Metazoa,3CYPS@33213|Bilateria,48ACP@7711|Chordata,4950Z@7742|Vertebrata,49Z7F@7898|Actinopterygii	33208|Metazoa	C	ATP-citrate synthase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues	ACLY	GO:0000166,GO:0000323,GO:0001775,GO:0002252,GO:0002263,GO:0002274,GO:0002275,GO:0002283,GO:0002366,GO:0002376,GO:0002443,GO:0002444,GO:0002446,GO:0003674,GO:0003824,GO:0003878,GO:0005488,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005737,GO:0005764,GO:0005766,GO:0005773,GO:0005775,GO:0005829,GO:0005886,GO:0006066,GO:0006082,GO:0006084,GO:0006085,GO:0006101,GO:0006107,GO:0006139,GO:0006163,GO:0006164,GO:0006629,GO:0006631,GO:0006633,GO:0006637,GO:0006694,GO:0006695,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006955,GO:0008144,GO:0008150,GO:0008152,GO:0008202,GO:0008203,GO:0008610,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009346,GO:0009893,GO:0009987,GO:0012505,GO:0015936,GO:0016020,GO:0016053,GO:0016125,GO:0016126,GO:0016192,GO:0016740,GO:0016746,GO:0016999,GO:0017076,GO:0017144,GO:0018130,GO:0019222,GO:0019438,GO:0019637,GO:0019693,GO:0019752,GO:0030141,GO:0030554,GO:0031323,GO:0031325,GO:0031410,GO:0031974,GO:0031981,GO:0031982,GO:0031983,GO:0032553,GO:0032555,GO:0032559,GO:0032787,GO:0032940,GO:0032991,GO:0033500,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0034774,GO:0035337,GO:0035383,GO:0035384,GO:0035578,GO:0035639,GO:0036094,GO:0036230,GO:0042119,GO:0042582,GO:0042592,GO:0042593,GO:0043167,GO:0043168,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043299,GO:0043312,GO:0043436,GO:0043603,GO:0043604,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044422,GO:0044424,GO:0044428,GO:0044433,GO:0044437,GO:0044444,GO:0044446,GO:0044464,GO:0045055,GO:0045321,GO:0046165,GO:0046390,GO:0046394,GO:0046483,GO:0046903,GO:0046912,GO:0046949,GO:0048518,GO:0048522,GO:0048878,GO:0050789,GO:0050794,GO:0050896,GO:0051179,GO:0051186,GO:0051188,GO:0051234,GO:0055086,GO:0060205,GO:0065007,GO:0065008,GO:0070013,GO:0071616,GO:0071704,GO:0071944,GO:0072330,GO:0072350,GO:0072521,GO:0072522,GO:0090407,GO:0097159,GO:0097367,GO:0097708,GO:0099503,GO:0101002,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901568,GO:1901570,GO:1901576,GO:1901615,GO:1901617,GO:1902652,GO:1902653,GO:1904813	2.3.3.8	ko:K01648	ko00020,ko00720,ko01100,ko01110,ko01120,ko01130,map00020,map00720,map01100,map01110,map01120,map01130	-	R00352	RC00004,RC00067	ko00000,ko00001,ko01000,ko04147	-	-	-	ATP-grasp_2,Citrate_bind,Citrate_synt,CoA_binding,Ligase_CoA
HKD1_k127_103303_3	269797.Mbar_A1961	7.043e-166	530.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N92R@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC-2	-	4.2.1.114	ko:K16792	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD1_k127_103303_13	304371.MCP_0454	1.152e-48	181.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,2N9Q2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART phosphoesterase PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD1_k127_103303_20	1279009.ADICEAN_03497	1.263e-14	83.0	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_1039329_0	247490.KSU1_C0383	4.545e-188	594.0	COG4487@1|root,COG4487@2|Bacteria,2J16Y@203682|Planctomycetes	203682|Planctomycetes	I	mechanosensitive ion channel activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2130
HKD1_k127_1039329_2	290397.Adeh_1405	1.284e-08	57.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,42MM5@68525|delta/epsilon subdivisions,2WJMN@28221|Deltaproteobacteria,2YZQB@29|Myxococcales	28221|Deltaproteobacteria	J	SEC-C motif	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24,SEC-C
HKD1_k127_1039329_1	269799.Gmet_0083	7.895e-18	90.0	COG0330@1|root,COG0330@2|Bacteria,1MW1D@1224|Proteobacteria,42PKQ@68525|delta/epsilon subdivisions,2WM5Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_1054642_1	269797.Mbar_A3641	1.473e-99	332.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,2N91W@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_1054642_0	237368.SCABRO_01637	1.427e-276	867.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_1060381_1	395495.Lcho_1386	1.141e-09	70.0	COG5653@1|root,COG5653@2|Bacteria,1NM01@1224|Proteobacteria,2W54Z@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_1060381_0	1198452.Jab_2c10120	6.087e-21	102.0	COG5653@1|root,COG5653@2|Bacteria,1NM01@1224|Proteobacteria,2W54Z@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_1099621_1	386456.JQKN01000002_gene2633	5.293e-21	97.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y01N@28890|Euryarchaeota	28890|Euryarchaeota	S	alkylhydroperoxidase like protein, AhpD family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_1099621_2	634499.EpC_30560	4.328e-17	85.0	COG1917@1|root,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,1S3RV@1236|Gammaproteobacteria,3X6PA@551|Erwinia	1236|Gammaproteobacteria	S	silverDB	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_1099621_0	1173020.Cha6605_1137	4.399e-138	454.0	COG1233@1|root,COG1233@2|Bacteria,1GCDS@1117|Cyanobacteria	1117|Cyanobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD1_k127_1099621_4	273075.Ta1144a	0.0005679	45.0	COG5466@1|root,arCOG05278@2157|Archaea,2Y5U3@28890|Euryarchaeota,242H8@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_1099621_3	319795.Dgeo_0714	1.369e-05	49.0	COG0517@1|root,COG0517@2|Bacteria,1WI6I@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	PFAM CBS domain	-	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	CBS
HKD1_k127_1107828_0	1041930.Mtc_2447	5.187e-164	524.0	COG0183@1|root,arCOG01278@2157|Archaea,2XT38@28890|Euryarchaeota,2N94P@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Thiolase	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0550	Thiolase_C,Thiolase_N
HKD1_k127_1107828_1	269797.Mbar_A0549	4.171e-49	179.0	COG1545@1|root,arCOG01285@2157|Archaea,2XXGF@28890|Euryarchaeota,2N9PT@224756|Methanomicrobia	224756|Methanomicrobia	V	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD1_k127_1107828_2	589924.Ferp_0346	7.439e-10	66.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,246E5@183980|Archaeoglobi	183980|Archaeoglobi	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_1107828_4	1094980.Mpsy_2189	6.051e-09	59.0	COG4059@1|root,arCOG04870@2157|Archaea,2XTGG@28890|Euryarchaeota,2N98Q@224756|Methanomicrobia	224756|Methanomicrobia	H	Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step	mtrE	-	2.1.1.86	ko:K00581	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrE
HKD1_k127_1107828_3	580340.Tlie_0338	4.304e-09	62.0	COG0591@1|root,COG0591@2|Bacteria,3TB7Q@508458|Synergistetes	508458|Synergistetes	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD1_k127_1113919_5	573063.Metin_0897	9.353e-26	111.0	COG1437@1|root,arCOG01723@2157|Archaea,2XYQS@28890|Euryarchaeota,23R09@183939|Methanococci	183939|Methanococci	F	PFAM Adenylate cyclase	-	GO:0003674,GO:0003824,GO:0004016,GO:0009975,GO:0016829,GO:0016849	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
HKD1_k127_1113919_2	192952.MM_0909	8.045e-71	251.0	COG3389@1|root,arCOG04463@2157|Archaea,2XSZT@28890|Euryarchaeota,2N9I2@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Peptidase A22, presenilin signal peptide	-	-	-	-	-	-	-	-	-	-	-	-	SPP
HKD1_k127_1113919_1	1120973.AQXL01000084_gene2777	1.196e-90	310.0	COG0123@1|root,COG0123@2|Bacteria,1TQF7@1239|Firmicutes,4HBTF@91061|Bacilli,2784E@186823|Alicyclobacillaceae	91061|Bacilli	BQ	Histone deacetylase domain	acuC	-	-	ko:K04768	-	-	-	-	ko00000	-	-	iYO844.BSU29710	Hist_deacetyl
HKD1_k127_1113919_4	497965.Cyan7822_3550	1.143e-29	120.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria	1117|Cyanobacteria	CJ	TIGRFAM acetyl coenzyme A synthetase (ADP forming), alpha domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
HKD1_k127_1113919_0	635013.TherJR_0525	2.3e-184	584.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_1113919_3	1147.D082_12800	9.364e-34	132.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1G2D3@1117|Cyanobacteria,1H64V@1142|Synechocystis	1117|Cyanobacteria	CJ	Acetyl-CoA hydrolase/transferase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro,Acetyltransf_1
HKD1_k127_1130981_2	1094980.Mpsy_2087	1.827e-111	371.0	COG0535@1|root,arCOG00943@2157|Archaea,2Y2FM@28890|Euryarchaeota,2NAHZ@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HKD1_k127_1130981_1	1041930.Mtc_2494	1.301e-175	558.0	COG0137@1|root,arCOG00112@2157|Archaea,2XU8K@28890|Euryarchaeota,2N9DR@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_1130981_5	456442.Mboo_1790	1.7e-28	118.0	COG4048@1|root,arCOG04902@2157|Archaea,2Y8FE@28890|Euryarchaeota,2N9Y6@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2111)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2111
HKD1_k127_1130981_6	428127.EUBDOL_00302	7.03e-16	83.0	COG0454@1|root,COG0456@2|Bacteria,1V6KU@1239|Firmicutes,3VR6K@526524|Erysipelotrichia	526524|Erysipelotrichia	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_1130981_4	351160.RCIX684	4.059e-32	133.0	COG1777@1|root,arCOG01684@2157|Archaea,2XUMR@28890|Euryarchaeota,2NA1M@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K07721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_1130981_0	224325.AF_1297	4.635e-296	925.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,245UG@183980|Archaeoglobi	183980|Archaeoglobi	O	AAA family ATPase, CDC48 subfamily	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N,Vps4_C
HKD1_k127_1130981_3	1094980.Mpsy_0809	2.481e-56	202.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
HKD1_k127_1150396_4	5888.CAK76755	2.047e-23	103.0	COG3914@1|root,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_1150396_6	386456.JQKN01000013_gene3073	8.305e-07	54.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_1150396_5	459495.SPLC1_S541370	1.151e-10	65.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_1150396_3	1041930.Mtc_0477	5.099e-32	130.0	COG1259@1|root,arCOG01759@2157|Archaea,2XWIM@28890|Euryarchaeota,2NA0M@224756|Methanomicrobia	224756|Methanomicrobia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD1_k127_1150396_0	1094980.Mpsy_0259	0.0	1356.0	COG0060@1|root,arCOG00807@2157|Archaea,2XTIX@28890|Euryarchaeota,2N9A3@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_1150396_1	224325.AF_2060	4.269e-134	434.0	COG0470@1|root,arCOG00469@2157|Archaea,2XTC8@28890|Euryarchaeota,24622@183980|Archaeoglobi	183980|Archaeoglobi	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcS	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA,Intein_splicing,Rep_fac_C,RuvB_N
HKD1_k127_1150396_2	632518.Calow_0437	2.451e-47	178.0	COG1878@1|root,COG1878@2|Bacteria,1UFUJ@1239|Firmicutes,24HGD@186801|Clostridia,42GJQ@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM cyclase family protein	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HKD1_k127_1153521_4	1094980.Mpsy_0035	3.42e-08	56.0	COG3335@1|root,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota,2N9Y3@224756|Methanomicrobia	224756|Methanomicrobia	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32,HTH_33
HKD1_k127_1153521_1	224719.Abm4_0074	6.031e-12	66.0	COG1742@1|root,arCOG07820@2157|Archaea,2XYGR@28890|Euryarchaeota,23PQ1@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterised BCR, YnfA/UPF0060 family	-	-	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
HKD1_k127_1153521_2	386456.JQKN01000008_gene1618	9.931e-12	68.0	COG1742@1|root,arCOG07820@2157|Archaea	2157|Archaea	S	PFAM Uncharacterised BCR, YnfA UPF0060 family	-	-	-	ko:K09771	-	-	-	-	ko00000,ko02000	2.A.7.26	-	-	UPF0060
HKD1_k127_1153521_0	387631.Asulf_00579	5.584e-50	185.0	COG2119@1|root,arCOG03458@2157|Archaea,2XYST@28890|Euryarchaeota,247C2@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_1153521_5	1094980.Mpsy_0015	0.0006215	44.0	COG2133@1|root,COG3794@1|root,arCOG10180@1|root,arCOG02796@2157|Archaea,arCOG02929@2157|Archaea,arCOG10180@2157|Archaea,2XT1Q@28890|Euryarchaeota,2NADP@224756|Methanomicrobia	224756|Methanomicrobia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_1153521_3	1123389.ATXJ01000001_gene699	2.045e-08	55.0	COG3794@1|root,COG3794@2|Bacteria,1WKPV@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD1_k127_1161053_0	269797.Mbar_A2604	5.562e-108	387.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAN4@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_1161053_4	351160.RCIX2718	6.966e-15	80.0	arCOG04038@1|root,arCOG04038@2157|Archaea,2Y5TS@28890|Euryarchaeota,2NBDA@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1161053_3	387631.Asulf_02173	2.695e-33	136.0	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_1161053_5	387631.Asulf_02173	7.448e-10	61.0	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_1161053_1	290317.Cpha266_1157	4.668e-48	178.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
HKD1_k127_1161053_2	368407.Memar_2030	1.959e-35	137.0	arCOG03165@1|root,arCOG03165@2157|Archaea,2XXAZ@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1162569_2	269797.Mbar_A2624	5.288e-54	191.0	COG4831@1|root,arCOG05211@2157|Archaea,2Y3XM@28890|Euryarchaeota,2NAZ8@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_1162569_1	639030.JHVA01000001_gene3713	1.835e-63	224.0	COG2823@1|root,COG2823@2|Bacteria,3Y7T6@57723|Acidobacteria,2JN0K@204432|Acidobacteriia	204432|Acidobacteriia	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_1162569_6	646529.Desaci_3168	4.529e-27	115.0	COG2905@1|root,COG2905@2|Bacteria,1VW3X@1239|Firmicutes,24MYP@186801|Clostridia,262DF@186807|Peptococcaceae	186801|Clostridia	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_1162569_7	269797.Mbar_A1892	3.901e-25	107.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1162569_4	323259.Mhun_0599	6.078e-37	145.0	COG0071@1|root,arCOG01832@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_1162569_9	368407.Memar_1503	6.961e-22	96.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	DnaJ,Fer4_13,Fer4_15
HKD1_k127_1162569_3	1227500.C494_11335	9.193e-40	151.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYCN@28890|Euryarchaeota,23W7U@183963|Halobacteria	183963|Halobacteria	S	homolog of gamma-carboxymuconolactone decarboxylase subunit	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_1162569_8	368407.Memar_0496	5.865e-25	107.0	arCOG03397@1|root,arCOG03397@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1162569_5	387631.Asulf_01706	1.048e-36	143.0	COG1814@1|root,arCOG01096@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_1162569_0	224325.AF_1310	5.244e-64	232.0	COG2801@1|root,arCOG02125@2157|Archaea,2XWYN@28890|Euryarchaeota,247HN@183980|Archaeoglobi	183980|Archaeoglobi	L	transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,rve
HKD1_k127_1179309_0	269797.Mbar_A1683	2.511e-122	397.0	COG0604@1|root,arCOG01458@2157|Archaea,2XURG@28890|Euryarchaeota,2N9N6@224756|Methanomicrobia	224756|Methanomicrobia	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD1_k127_1187597_0	1041930.Mtc_0206	2.606e-97	325.0	COG0463@1|root,arCOG00894@2157|Archaea,2XTEG@28890|Euryarchaeota,2N988@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_1187597_2	1041930.Mtc_1252	3.118e-66	242.0	COG1109@1|root,arCOG00767@2157|Archaea,2XT1X@28890|Euryarchaeota,2N95J@224756|Methanomicrobia	224756|Methanomicrobia	G	Phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2225	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_1187597_1	192952.MM_2288	9.986e-96	320.0	COG0293@1|root,arCOG00079@2157|Archaea,2XT12@28890|Euryarchaeota,2N955@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,TRAM
HKD1_k127_1187597_3	521011.Mpal_1538	0.000539	43.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
HKD1_k127_1190238_4	877455.Metbo_0567	1.1e-44	166.0	COG0365@1|root,arCOG01529@2157|Archaea,2XTAB@28890|Euryarchaeota,23NWY@183925|Methanobacteria	183925|Methanobacteria	I	TIGRFAM Acetate-CoA ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_1190238_2	1379281.AVAG01000023_gene1915	5.558e-81	274.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42N9V@68525|delta/epsilon subdivisions,2WJWQ@28221|Deltaproteobacteria,2M9B4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	rbr	GO:0003674,GO:0005488,GO:0005506,GO:0043167,GO:0043169,GO:0046872,GO:0046914	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_1190238_1	351160.RCIX1328	6.598e-113	377.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase, group 1	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_1190238_0	868131.MSWAN_1119	4.803e-152	490.0	arCOG11926@1|root,arCOG11926@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1190238_3	521011.Mpal_1256	2.709e-58	215.0	arCOG04555@1|root,arCOG04555@2157|Archaea,2XUY2@28890|Euryarchaeota,2N9YH@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1195492_0	192952.MM_0729	2.115e-34	136.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	sCache_2
HKD1_k127_1195492_2	521011.Mpal_1452	7.125e-29	121.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	sCache_2
HKD1_k127_1195492_4	323259.Mhun_1064	1.351e-15	82.0	arCOG09494@1|root,arCOG09494@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1195492_1	456442.Mboo_2259	4.626e-34	133.0	arCOG02290@1|root,arCOG02290@2157|Archaea,2XWJW@28890|Euryarchaeota,2N9PB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_1195492_3	456442.Mboo_2259	8.798e-26	109.0	arCOG02290@1|root,arCOG02290@2157|Archaea,2XWJW@28890|Euryarchaeota,2N9PB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_1212223_0	521011.Mpal_2113	7.367e-123	411.0	COG0834@1|root,COG1301@1|root,arCOG01799@2157|Archaea,arCOG04335@2157|Archaea	2157|Archaea	C	COG1301 Na H -dicarboxylate symporters	gltP	GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039	-	ko:K02030,ko:K07862	-	M00236	-	-	ko00000,ko00002,ko02000	2.A.23.4,3.A.1.3	-	-	SBP_bac_3,SDF
HKD1_k127_1214890_9	880072.Desac_0709	2.905e-15	77.0	COG0461@1|root,COG0461@2|Bacteria,1PI8N@1224|Proteobacteria,42QSR@68525|delta/epsilon subdivisions,2WMT5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_1214890_5	192952.MM_1914	2.016e-68	241.0	COG1407@1|root,arCOG01150@2157|Archaea,2XU3W@28890|Euryarchaeota,2N9DU@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metallophosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_1214890_7	573370.DMR_11960	5.858e-25	108.0	COG3613@1|root,COG3613@2|Bacteria,1MZSA@1224|Proteobacteria,42XC4@68525|delta/epsilon subdivisions,2WT4P@28221|Deltaproteobacteria,2MBRI@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM Nucleoside 2-deoxyribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Nuc_deoxyrib_tr
HKD1_k127_1214890_0	192952.MM_1696	1.276e-184	590.0	COG1384@1|root,arCOG00485@2157|Archaea,2XTR5@28890|Euryarchaeota,2N9FV@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
HKD1_k127_1214890_6	1041930.Mtc_0597	3.491e-62	217.0	COG2131@1|root,arCOG01487@2157|Archaea,2XXBC@28890|Euryarchaeota,2N9NF@224756|Methanomicrobia	224756|Methanomicrobia	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HKD1_k127_1214890_1	572546.Arcpr_0931	5.776e-152	492.0	COG0019@1|root,arCOG02268@2157|Archaea,2XSY8@28890|Euryarchaeota,246P1@183980|Archaeoglobi	183980|Archaeoglobi	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_1214890_2	224325.AF_1519	1.332e-83	281.0	COG0655@1|root,arCOG02573@2157|Archaea,2XVV1@28890|Euryarchaeota,246SB@183980|Archaeoglobi	183980|Archaeoglobi	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_1214890_3	868131.MSWAN_1067	9.054e-72	246.0	COG1036@1|root,arCOG01705@2157|Archaea,2XXGS@28890|Euryarchaeota	28890|Euryarchaeota	C	TIGRFAM archaeoflavoprotein AfpA	-	-	-	-	-	-	-	-	-	-	-	-	Flavoprotein
HKD1_k127_1214890_4	387631.Asulf_02173	1.369e-69	246.0	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_1214890_8	556268.OFAG_00835	3.713e-24	119.0	COG2963@1|root,COG2963@2|Bacteria,1PCWW@1224|Proteobacteria,2VKXF@28216|Betaproteobacteria,47377@75682|Oxalobacteraceae	28216|Betaproteobacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1230340_2	1094980.Mpsy_0015	7.325e-157	509.0	COG2133@1|root,COG3794@1|root,arCOG10180@1|root,arCOG02796@2157|Archaea,arCOG02929@2157|Archaea,arCOG10180@2157|Archaea,2XT1Q@28890|Euryarchaeota,2NADP@224756|Methanomicrobia	224756|Methanomicrobia	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_1230340_1	891968.Anamo_1584	8.557e-167	534.0	COG0438@1|root,COG0438@2|Bacteria,3TAFG@508458|Synergistetes	508458|Synergistetes	H	PFAM glycosyl transferase group 1	-	-	2.4.1.245	ko:K13057	ko00500,ko01100,map00500,map01100	-	R08946,R10525,R11306	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000	-	GT4	-	Glycos_transf_1
HKD1_k127_1230340_0	891968.Anamo_1586	4.345e-274	861.0	COG0380@1|root,COG1877@1|root,COG0380@2|Bacteria,COG1877@2|Bacteria,3TA4P@508458|Synergistetes	508458|Synergistetes	G	PFAM glycosyl transferase family 20	-	-	2.4.1.15,2.4.1.347,3.1.3.12	ko:K00697,ko:K16055	ko00500,ko01100,map00500,map01100	-	R02737,R02778	RC00005,RC00017,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT20	-	Glyco_transf_20,Trehalose_PPase
HKD1_k127_1230340_8	573063.Metin_0860	4.082e-19	93.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23QUR@183939|Methanococci	183939|Methanococci	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_1230340_5	593750.Metfor_0139	8.942e-71	244.0	COG1280@1|root,arCOG01947@2157|Archaea,2XY47@28890|Euryarchaeota,2N9SP@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD1_k127_1230340_4	485916.Dtox_0888	9.273e-84	281.0	COG1751@1|root,COG1751@2|Bacteria	2|Bacteria	S	PFAM Pyruvate kinase, alpha beta domain	-	-	-	ko:K09126	-	-	-	-	ko00000	-	-	-	PK_C
HKD1_k127_1230340_6	565033.GACE_0473	2.238e-45	172.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota,2470F@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_1230340_3	456442.Mboo_1037	3.161e-106	352.0	COG2006@1|root,arCOG02446@2157|Archaea,2XV9B@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_1230340_7	399550.Smar_0566	1.641e-27	117.0	COG4315@1|root,arCOG08235@2157|Archaea	2157|Archaea	C	PFAM Secreted repeat of	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HKD1_k127_1258806_2	1033743.CAES01000036_gene1216	2.147e-10	65.0	COG1409@1|root,COG1409@2|Bacteria,1TPQQ@1239|Firmicutes,4HC2W@91061|Bacilli,26S3Z@186822|Paenibacillaceae	91061|Bacilli	U	Lamin Tail Domain	yvnB	-	-	-	-	-	-	-	-	-	-	-	LTD,Metallophos,SLH,fn3
HKD1_k127_1258806_1	1120960.ATXG01000002_gene3034	4.342e-12	71.0	COG1409@1|root,COG3087@1|root,COG1409@2|Bacteria,COG3087@2|Bacteria,2GNU9@201174|Actinobacteria	201174|Actinobacteria	V	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	CBM60,Metallophos,PKD
HKD1_k127_1258806_3	381764.Fnod_1302	0.0004317	43.0	COG0369@1|root,COG1151@2|Bacteria,2GBYD@200918|Thermotogae	200918|Thermotogae	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
HKD1_k127_1258806_0	515635.Dtur_1286	6.703e-88	306.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122
HKD1_k127_1266776_9	1214101.BN159_0442	2.465e-06	49.0	COG1359@1|root,COG1359@2|Bacteria,2GT9F@201174|Actinobacteria	201174|Actinobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1266776_5	913865.DOT_5174	3.489e-20	94.0	COG1765@1|root,COG1765@2|Bacteria	2|Bacteria	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	DUF3795,OsmC
HKD1_k127_1266776_0	1094980.Mpsy_0823	4.913e-104	345.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2NAE5@224756|Methanomicrobia	224756|Methanomicrobia	O	Peptidase family M48	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_1266776_4	192952.MM_2671	4.95e-42	169.0	COG0628@1|root,arCOG02642@2157|Archaea,2XT00@28890|Euryarchaeota	28890|Euryarchaeota	S	Permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_1266776_8	272562.CA_C0546	4.152e-10	66.0	2E61F@1|root,330QP@2|Bacteria,1VJWC@1239|Firmicutes,24V6X@186801|Clostridia,36PU4@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF4064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4064
HKD1_k127_1266776_1	368407.Memar_1826	1.178e-68	242.0	COG0531@1|root,arCOG00009@2157|Archaea,2XTX6@28890|Euryarchaeota,2N9VR@224756|Methanomicrobia	224756|Methanomicrobia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1266776_6	1122247.C731_3753	8.896e-15	83.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,23495@1762|Mycobacteriaceae	201174|Actinobacteria	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_1266776_10	386456.JQKN01000023_gene69	0.0001071	44.0	COG1985@1|root,arCOG01489@2157|Archaea,2Y3MD@28890|Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
HKD1_k127_1266776_7	386456.JQKN01000023_gene69	6.352e-14	76.0	COG1985@1|root,arCOG01489@2157|Archaea,2Y3MD@28890|Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	-	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
HKD1_k127_1266776_2	304371.MCP_2944	6.1e-57	207.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,2NB7U@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1266776_3	521011.Mpal_0017	1.078e-51	188.0	COG0500@1|root,arCOG02702@2157|Archaea,2XWS9@28890|Euryarchaeota,2NAVE@224756|Methanomicrobia	224756|Methanomicrobia	Q	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_1285718_5	192952.MM_1837	7.831e-67	235.0	COG0565@1|root,arCOG01018@2157|Archaea,2XUIY@28890|Euryarchaeota,2N9I5@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM RNA methyltransferase, TrmH family, group 1	-	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_1285718_14	5888.CAK87292	1.327e-23	106.0	COG3914@1|root,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_1285718_0	386456.JQKN01000002_gene2884	5.568e-223	717.0	COG0826@1|root,arCOG03203@2157|Archaea,2XT7F@28890|Euryarchaeota,23PCI@183925|Methanobacteria	183925|Methanobacteria	O	peptidase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD1_k127_1285718_3	192952.MM_1237	7.827e-86	289.0	COG0207@1|root,arCOG03214@2157|Archaea,2XYEP@28890|Euryarchaeota,2NBGJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the thymidylate synthase family. Archaeal- type ThyA subfamily	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD1_k127_1285718_11	368407.Memar_1730	1.254e-35	142.0	arCOG04970@1|root,arCOG04970@2157|Archaea,2XZKF@28890|Euryarchaeota,2N9TS@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hjc
HKD1_k127_1285718_12	679926.Mpet_1754	1.072e-29	124.0	COG2242@1|root,arCOG00977@2157|Archaea,2XVKZ@28890|Euryarchaeota,2N9SF@224756|Methanomicrobia	224756|Methanomicrobia	Q	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_18,Methyltransf_25,Methyltransf_31
HKD1_k127_1285718_7	269797.Mbar_A0626	1.394e-58	209.0	COG2243@1|root,arCOG00648@2157|Archaea,2XTS5@28890|Euryarchaeota,2N9NT@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_1285718_4	1094980.Mpsy_2057	4.034e-85	288.0	COG2875@1|root,arCOG00645@2157|Archaea,2XSZA@28890|Euryarchaeota,2N9G2@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0627	TP_methylase
HKD1_k127_1285718_8	593750.Metfor_1476	1.57e-51	194.0	COG2073@1|root,arCOG00651@2157|Archaea,2XTVD@28890|Euryarchaeota,2N9TZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM cobalamin (vitamin B12) biosynthesis CbiG protein	-	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N
HKD1_k127_1285718_10	555079.Toce_0317	2.472e-40	166.0	COG1010@1|root,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,247QS@186801|Clostridia,42G3M@68295|Thermoanaerobacterales	186801|Clostridia	H	PFAM Uroporphyrin-III C tetrapyrrole (Corrin Porphyrin) methyltransferase	cobJ	-	2.1.1.131,2.1.1.272	ko:K05934,ko:K21479	ko00860,ko01100,map00860,map01100	-	R05180,R05809,R11580	RC00003,RC01293,RC03471,RC03479	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_1285718_6	368407.Memar_0513	2.853e-63	224.0	COG2082@1|root,arCOG02247@2157|Archaea,2XT0S@28890|Euryarchaeota,2N9MJ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Precorrin-8X methylmutase CbiC CobH	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0630	CbiC
HKD1_k127_1285718_2	192952.MM_1681	2.292e-87	299.0	COG1903@1|root,arCOG04383@2157|Archaea,2XV53@28890|Euryarchaeota,2N9AY@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
HKD1_k127_1285718_9	456442.Mboo_1223	2.611e-42	162.0	COG2241@1|root,arCOG00650@2157|Archaea,2XZ22@28890|Euryarchaeota,2N9VQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Precorrin-6y C5,15-methyltransferase (Decarboxylating), CbiE subunit	cbiE	-	2.1.1.289	ko:K03399	ko00860,ko01100,map00860,map01100	-	R05813,R07775	RC00003,RC02052,RC02053	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1492	TP_methylase
HKD1_k127_1285718_15	304371.MCP_0043	7.775e-11	68.0	COG1645@1|root,arCOG00578@2157|Archaea,2Y1BV@28890|Euryarchaeota,2NA6C@224756|Methanomicrobia	224756|Methanomicrobia	S	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
HKD1_k127_1285718_13	1041930.Mtc_0431	4.604e-28	115.0	COG1698@1|root,arCOG04308@2157|Archaea,2XZVX@28890|Euryarchaeota,2N9Y5@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
HKD1_k127_1285718_1	269797.Mbar_A0976	6.031e-120	391.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,2N983@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_22,Cdc6_C
HKD1_k127_129462_0	192952.MM_3076	1.88e-273	859.0	COG0550@1|root,arCOG01527@2157|Archaea,arCOG06233@2157|Archaea,2XU6T@28890|Euryarchaeota,2N96B@224756|Methanomicrobia	224756|Methanomicrobia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	HHH_5,Topoisom_bac,Toprim,zf-C4_Topoisom
HKD1_k127_129462_2	1094980.Mpsy_0832	4.55e-182	578.0	COG4054@1|root,arCOG04860@2157|Archaea,2XTPD@28890|Euryarchaeota,2N9BX@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Methyl-coenzyme M reductase, beta subunit	mcrB	-	2.8.4.1	ko:K00401	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04541	RC00011,RC01542	ko00000,ko00001,ko00002,ko01000	-	-	-	MCR_beta,MCR_beta_N
HKD1_k127_129462_5	192952.MM_1243	2.767e-38	149.0	COG4055@1|root,arCOG04859@2157|Archaea,2XZ5V@28890|Euryarchaeota,2NBJT@224756|Methanomicrobia	224756|Methanomicrobia	H	Methyl-coenzyme M reductase operon protein D	mcrD	-	-	ko:K03422	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	MCR_D
HKD1_k127_129462_3	1094980.Mpsy_0829	5.753e-101	334.0	COG4057@1|root,arCOG04858@2157|Archaea,2XSVR@28890|Euryarchaeota,2N92T@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Methyl-coenzyme M reductase gamma subunit	mcrG	-	2.8.4.1	ko:K00402	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04541	RC00011,RC01542	ko00000,ko00001,ko00002,ko01000	-	-	-	MCR_gamma
HKD1_k127_129462_1	304371.MCP_0516	6.974e-256	799.0	COG4058@1|root,arCOG04857@2157|Archaea,2XTF8@28890|Euryarchaeota,2N90K@224756|Methanomicrobia	224756|Methanomicrobia	H	Reduction of methyl-coenzyme M (2-(methylthio) ethanesulfonic acid) with 7-mercaptoheptanoylthreonine phosphate to methane and a heterodisulfide	mcrA	-	2.8.4.1	ko:K00399	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04541	RC00011,RC01542	ko00000,ko00001,ko00002,ko01000	-	-	-	MCR_alpha,MCR_alpha_N
HKD1_k127_129462_4	269797.Mbar_A2624	2.212e-54	192.0	COG4831@1|root,arCOG05211@2157|Archaea,2Y3XM@28890|Euryarchaeota,2NAZ8@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_1302173_0	868131.MSWAN_1817	2.611e-71	243.0	COG5485@1|root,arCOG06513@2157|Archaea,2Y3E5@28890|Euryarchaeota	28890|Euryarchaeota	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_1302173_1	765911.Thivi_1556	0.0001199	44.0	COG1675@1|root,COG1675@2|Bacteria,1MZ5R@1224|Proteobacteria,1SEBH@1236|Gammaproteobacteria,1X1E1@135613|Chromatiales	135613|Chromatiales	K	transcription initiation from RNA polymerase II promoter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1304265_0	5888.CAK77044	1.279e-35	146.0	COG3914@1|root,KOG4626@2759|Eukaryota	2759|Eukaryota	O	protein N-acetylglucosaminyltransferase activity	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_1327907_0	1094980.Mpsy_2804	1.766e-120	393.0	COG1234@1|root,arCOG00501@2157|Archaea,2XTJ9@28890|Euryarchaeota,2N96S@224756|Methanomicrobia	224756|Methanomicrobia	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_1342688_0	319225.Plut_1246	2.062e-33	136.0	COG0226@1|root,COG0226@2|Bacteria,1FF16@1090|Chlorobi	1090|Chlorobi	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD1_k127_1342688_1	1303518.CCALI_01752	5.849e-08	64.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD1_k127_1363695_2	75379.Tint_0749	3.009e-18	96.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2VX9Q@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD1_k127_1363695_0	93220.LV28_01620	8.275e-29	116.0	COG4572@1|root,COG4572@2|Bacteria,1N93H@1224|Proteobacteria,2VX6M@28216|Betaproteobacteria,1KA9D@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cation transport regulator	-	-	-	ko:K06197	-	-	-	-	ko00000	-	-	-	ChaB
HKD1_k127_1425788_2	304371.MCP_1408	1.298e-87	299.0	COG1676@1|root,arCOG01701@2157|Archaea,2XTKB@28890|Euryarchaeota,2N92W@224756|Methanomicrobia	224756|Methanomicrobia	J	sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp	endA	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
HKD1_k127_1425788_12	694430.Natoc_0189	2.757e-10	72.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,23SWV@183963|Halobacteria	183963|Halobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
HKD1_k127_1425788_7	304371.MCP_1347	3.158e-48	179.0	COG0529@1|root,arCOG01040@2157|Archaea,2XU4H@28890|Euryarchaeota,2NBDX@224756|Methanomicrobia	224756|Methanomicrobia	P	Adenylylsulphate kinase	cysC	-	2.7.1.25	ko:K00860	ko00230,ko00920,ko01100,ko01120,map00230,map00920,map01100,map01120	M00176	R00509,R04928	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase
HKD1_k127_1425788_10	1094980.Mpsy_1384	2.912e-28	115.0	arCOG04743@1|root,arCOG04743@2157|Archaea,2XXSX@28890|Euryarchaeota,2NA4F@224756|Methanomicrobia	224756|Methanomicrobia	S	Non-histone chromosomal protein MC1	-	-	-	-	-	-	-	-	-	-	-	-	MC1
HKD1_k127_1425788_11	272844.PAB1168	1.897e-26	111.0	COG2058@1|root,arCOG04287@2157|Archaea,2XYQ9@28890|Euryarchaeota,244BE@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
HKD1_k127_1425788_6	1094980.Mpsy_1500	3.636e-62	226.0	COG0244@1|root,arCOG04288@2157|Archaea,2XU7C@28890|Euryarchaeota,2N993@224756|Methanomicrobia	224756|Methanomicrobia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl10	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD1_k127_1425788_4	1041930.Mtc_1421	9.579e-70	242.0	COG0081@1|root,arCOG04289@2157|Archaea,2XTJF@28890|Euryarchaeota,2N9HV@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds directly to 23S rRNA. Probably involved in E site tRNA release	rpl1	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD1_k127_1425788_8	186497.PF1991	1.165e-47	175.0	COG0080@1|root,arCOG04372@2157|Archaea,2XTJN@28890|Euryarchaeota,243FN@183968|Thermococci	183968|Thermococci	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rpl11	GO:0000027,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD1_k127_1425788_5	1041930.Mtc_2071	1.24e-65	226.0	COG0250@1|root,arCOG01920@2157|Archaea,2XWGQ@28890|Euryarchaeota,2N9MV@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
HKD1_k127_1425788_13	1041930.Mtc_0621	1.235e-09	61.0	arCOG02754@1|root,arCOG10890@1|root,arCOG02754@2157|Archaea,arCOG10890@2157|Archaea,2Y0JM@28890|Euryarchaeota	28890|Euryarchaeota	L	SPTR Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_1425788_9	456442.Mboo_0815	1.604e-40	156.0	arCOG04725@1|root,arCOG04725@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD1_k127_1425788_3	1094980.Mpsy_1912	1.753e-77	270.0	COG1041@1|root,arCOG00047@2157|Archaea,2XTD6@28890|Euryarchaeota,2N9HA@224756|Methanomicrobia	224756|Methanomicrobia	Q	RNA methylase	trmL	-	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
HKD1_k127_1425788_1	1041930.Mtc_1045	4.92e-128	418.0	arCOG01186@1|root,arCOG01186@2157|Archaea	2157|Archaea	G	Mn2 dependent serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD1_k127_1425788_0	351160.RRC46	1.038e-184	584.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,2N9AH@224756|Methanomicrobia	224756|Methanomicrobia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_1427698_0	192952.MM_2246	4.063e-29	119.0	COG0640@1|root,arCOG01681@2157|Archaea,2XYSN@28890|Euryarchaeota,2NBKM@224756|Methanomicrobia	224756|Methanomicrobia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_1427698_1	768704.Desmer_1830	1.409e-11	77.0	COG0526@1|root,COG4232@1|root,COG0526@2|Bacteria,COG4232@2|Bacteria,1V9UQ@1239|Firmicutes,24DK4@186801|Clostridia,262P8@186807|Peptococcaceae	186801|Clostridia	CO	cytochrome c biogenesis protein, transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD,Thioredoxin
HKD1_k127_144207_0	1094980.Mpsy_2713	4.692e-202	636.0	COG0423@1|root,COG0525@1|root,arCOG00405@2157|Archaea,arCOG00808@2157|Archaea,2XSXQ@28890|Euryarchaeota,2N93W@224756|Methanomicrobia	224756|Methanomicrobia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1976	Anticodon_1,tRNA-synt_1
HKD1_k127_144207_1	269797.Mbar_A2412	4.315e-52	189.0	COG2042@1|root,arCOG04733@2157|Archaea,2XVBD@28890|Euryarchaeota,2N9PH@224756|Methanomicrobia	224756|Methanomicrobia	J	pre-rRNA processing protein involved in ribosome biogenesis	-	-	-	ko:K09140	-	-	-	-	ko00000,ko03009	-	-	-	RLI,Ribo_biogen_C
HKD1_k127_144207_2	351160.RCIX298	1.337e-07	59.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,2N9V8@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_1458018_4	192952.MM_0642	1.713e-77	265.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N94T@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	aksF	-	1.1.1.87	ko:K10978	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00608	R01934,R01936,R04862,R08214,R08215	RC00084,RC00114,RC00626	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_1458018_5	192952.MM_0644	8.251e-75	259.0	arCOG04973@1|root,arCOG04973@2157|Archaea,2XX73@28890|Euryarchaeota,2N9K2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1458018_6	1094980.Mpsy_2354	7.125e-62	218.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2N9JK@224756|Methanomicrobia	224756|Methanomicrobia	E	Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis- homo(3)-aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B	hacB	-	4.2.1.114	ko:K16793	ko00300,ko00680,ko01100,ko01120,ko01130,ko01210,ko01230,map00300,map00680,map01100,map01120,map01130,map01210,map01230	M00433,M00608	R03444,R04371,R09720,R10391,R10392,R10393,R10394,R10395,R10396	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2270	Aconitase_C
HKD1_k127_1458018_2	304371.MCP_0411	3.429e-86	291.0	COG0396@1|root,arCOG04236@2157|Archaea,2XT6T@28890|Euryarchaeota,2N9GZ@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD1_k127_1458018_1	311424.DhcVS_720	5.825e-127	417.0	COG0719@1|root,COG0719@2|Bacteria,2G5TI@200795|Chloroflexi,34D5V@301297|Dehalococcoidia	301297|Dehalococcoidia	O	Uncharacterized protein family (UPF0051)	-	-	-	ko:K07033	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_1458018_8	1094980.Mpsy_2661	1.835e-10	64.0	arCOG06113@1|root,arCOG06113@2157|Archaea,2Y130@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1458018_7	344747.PM8797T_27557	4.178e-24	109.0	COG2755@1|root,COG3055@1|root,COG2755@2|Bacteria,COG3055@2|Bacteria,2IY7R@203682|Planctomycetes	203682|Planctomycetes	E	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	Kelch_1
HKD1_k127_1458018_3	1094980.Mpsy_0488	6.766e-84	285.0	COG0159@1|root,arCOG01086@2157|Archaea,2XTAW@28890|Euryarchaeota,2N9KY@224756|Methanomicrobia	224756|Methanomicrobia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD1_k127_1458018_0	269797.Mbar_A3622	1.043e-153	495.0	COG0133@1|root,arCOG01433@2157|Archaea,2XUHQ@28890|Euryarchaeota,2N9DF@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_1463301_4	1094980.Mpsy_1834	5.626e-43	160.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_1463301_9	1094980.Mpsy_1496	3.595e-10	63.0	COG2443@1|root,arCOG02204@2157|Archaea,2Y188@28890|Euryarchaeota,2NA63@224756|Methanomicrobia	224756|Methanomicrobia	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
HKD1_k127_1463301_1	1094980.Mpsy_0959	2.168e-143	463.0	COG2710@1|root,arCOG04888@2157|Archaea,2XUYC@28890|Euryarchaeota,2N90I@224756|Methanomicrobia	224756|Methanomicrobia	C	Methanogenesis marker 13 metalloprotein	-	-	6.3.3.7	ko:K21611	ko00860,ko01120,map00860,map01120	M00836	R11628	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
HKD1_k127_1463301_2	1094980.Mpsy_0961	1.089e-66	243.0	COG0770@1|root,arCOG02822@2157|Archaea,2XX2Y@28890|Euryarchaeota,2N9JG@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Mur ligase, middle domain protein	murD	-	6.4.1.9	ko:K21612	ko00860,ko01120,map00860,map01120	M00836	R11629	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
HKD1_k127_1463301_5	1094980.Mpsy_2755	2.769e-30	124.0	COG2138@1|root,arCOG02246@2157|Archaea,2XTSY@28890|Euryarchaeota,2N9W8@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the insertion of Co(2 ) into sirohydrochlorin as part of the anaerobic pathway to cobalamin biosynthesis. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl- coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the insertion of Ni(2 ) into sirohydrochlorin to yield Ni- sirohydrochlorin	cbiX	-	4.99.1.11,4.99.1.3	ko:K22011	ko00860,ko01100,map00860,map01100	M00836	R05807,R11626	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2400	CbiX
HKD1_k127_1463301_13	394.NGR_c00940	0.0003761	47.0	COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2TUXA@28211|Alphaproteobacteria,4BNFX@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_1463301_10	640511.BC1002_3664	4.277e-08	57.0	COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2WFGW@28216|Betaproteobacteria,1K11B@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_1463301_0	56110.Oscil6304_5561	4.256e-152	527.0	COG0642@1|root,COG2202@1|root,COG0642@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
HKD1_k127_1463301_3	386456.JQKN01000007_gene3197	2.697e-65	256.0	arCOG03567@1|root,arCOG03567@2157|Archaea	2157|Archaea	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_1463301_12	324602.Caur_0650	6.094e-05	49.0	COG0739@1|root,COG1716@1|root,COG3291@1|root,COG4733@1|root,COG0739@2|Bacteria,COG1716@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,2GBJ3@200795|Chloroflexi,377JF@32061|Chloroflexia	32061|Chloroflexia	MT	Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	PA14,Peptidase_C11,Peptidase_M23,fn3
HKD1_k127_1463301_8	868131.MSWAN_1856	2.181e-10	63.0	COG5483@1|root,arCOG00723@2157|Archaea,2XYZG@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_1463301_6	1173029.JH980292_gene4138	3.354e-28	115.0	COG5483@1|root,COG5483@2|Bacteria,1G4A0@1117|Cyanobacteria,1HA2T@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_1463301_7	1038860.AXAP01000067_gene8437	1.087e-18	93.0	COG1533@1|root,COG1533@2|Bacteria,1N5ZN@1224|Proteobacteria,2UPYJ@28211|Alphaproteobacteria,3K3GY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DNA photolyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_146663_1	192952.MM_0127	1.925e-70	249.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_146663_0	1094980.Mpsy_0809	2.503e-225	708.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
HKD1_k127_1483669_5	329726.AM1_4207	1.866e-12	68.0	COG3335@1|root,COG3335@2|Bacteria,1G5W5@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD1_k127_1483669_0	269797.Mbar_A1610	2.343e-65	230.0	COG1036@1|root,arCOG01705@2157|Archaea,2XX7Y@28890|Euryarchaeota,2NAPS@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavoprotein	-	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016645,GO:0018130,GO:0019438,GO:0019637,GO:0019752,GO:0034641,GO:0042558,GO:0042559,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901283,GO:1901285,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:2001115,GO:2001116,GO:2001117,GO:2001118	1.5.99.15	ko:K18853	ko00790,map00790	-	R10802	RC01584	ko00000,ko00001,ko01000	-	-	-	Fer4,Flavoprotein
HKD1_k127_1483669_6	1365176.N186_01450	1.362e-11	74.0	COG0582@1|root,arCOG01241@2157|Archaea,2XPNW@28889|Crenarchaeota	28889|Crenarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase,zinc_ribbon_2
HKD1_k127_1483669_2	694440.JOMF01000004_gene1288	5.292e-33	134.0	COG0314@1|root,arCOG00534@2157|Archaea	2157|Archaea	H	PFAM molybdopterin biosynthesis MoaE	moaE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009144,GO:0009150,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0016740,GO:0016782,GO:0016783,GO:0018130,GO:0019538,GO:0019637,GO:0019693,GO:0030366,GO:0032324,GO:0034641,GO:0042278,GO:0043170,GO:0043545,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046039,GO:0046128,GO:0046483,GO:0051186,GO:0051188,GO:0051189,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HKD1_k127_1483669_3	933801.Ahos_1406	1.102e-22	102.0	COG1324@1|root,arCOG04231@2157|Archaea,2XR9J@28889|Crenarchaeota	28889|Crenarchaeota	P	PFAM CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD1_k127_1483669_1	868595.Desca_2712	2.232e-36	143.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,2620E@186807|Peptococcaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD1_k127_1483669_7	479434.Sthe_1265	4.876e-05	49.0	COG4803@1|root,COG4803@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_15361_1	368407.Memar_2032	1.314e-97	325.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,2N9NQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD1_k127_15361_0	456442.Mboo_2091	5.161e-171	553.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD1_k127_1537196_0	316067.Geob_0309	2.684e-52	188.0	COG4885@1|root,COG4885@2|Bacteria,1R65B@1224|Proteobacteria,42Q86@68525|delta/epsilon subdivisions,2X5VK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HKD1_k127_1545017_8	1094980.Mpsy_1195	2.221e-53	194.0	COG1899@1|root,arCOG04142@2157|Archaea,2XUTF@28890|Euryarchaeota,2N9AF@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-1	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD1_k127_1545017_1	521674.Plim_3789	7.744e-173	563.0	COG1166@1|root,COG1166@2|Bacteria,2IX6P@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD1_k127_1545017_4	1094980.Mpsy_2741	6.491e-114	384.0	COG4231@1|root,arCOG01612@2157|Archaea,2XWAR@28890|Euryarchaeota,2N95R@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	-	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR_N,TPP_enzyme_C,TPP_enzyme_N
HKD1_k127_1545017_5	192952.MM_2789	1.226e-94	318.0	COG1571@1|root,arCOG01116@2157|Archaea,2XTUY@28890|Euryarchaeota,2N933@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1743)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1743
HKD1_k127_1545017_3	1041930.Mtc_1489	6.423e-125	413.0	COG0585@1|root,arCOG04252@2157|Archaea,2XUTK@28890|Euryarchaeota,2N928@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
HKD1_k127_1545017_10	572546.Arcpr_1709	6.345e-39	147.0	COG1990@1|root,arCOG04228@2157|Archaea,2XYRE@28890|Euryarchaeota,2473R@183980|Archaeoglobi	183980|Archaeoglobi	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K04794	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	PTH2
HKD1_k127_1545017_2	1041930.Mtc_0514	2.896e-149	484.0	COG0358@1|root,arCOG04281@2157|Archaea,2XTHB@28890|Euryarchaeota,2N98U@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4
HKD1_k127_1545017_7	1041930.Mtc_2505	7.804e-56	208.0	COG1499@1|root,arCOG04149@2157|Archaea,2XUAI@28890|Euryarchaeota,2N9GP@224756|Methanomicrobia	224756|Methanomicrobia	J	pfam nmd3	-	-	-	ko:K07562	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko03009	-	-	-	NMD3
HKD1_k127_1545017_11	273116.14325298	1.169e-20	94.0	COG2412@1|root,arCOG04051@2157|Archaea,2XYQK@28890|Euryarchaeota,241X0@183967|Thermoplasmata	183967|Thermoplasmata	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
HKD1_k127_1545017_0	1094980.Mpsy_0933	5.954e-245	775.0	COG1241@1|root,arCOG00439@2157|Archaea,2XT5D@28890|Euryarchaeota,2N9E6@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the MCM family	mcm	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
HKD1_k127_1545017_14	224325.AF_1113	7.448e-17	80.0	COG1998@1|root,arCOG04183@2157|Archaea,2XZZ0@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
HKD1_k127_1545017_13	192952.MM_0599	8.588e-20	92.0	COG2004@1|root,arCOG04182@2157|Archaea,2XXXB@28890|Euryarchaeota,2NA0E@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS24 family	rps24e	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S24e
HKD1_k127_1545017_9	269797.Mbar_A0283	1.56e-42	162.0	COG1909@1|root,arCOG04076@2157|Archaea,2XXSG@28890|Euryarchaeota,2N9R8@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0218 family	-	-	-	ko:K09735	-	-	-	-	ko00000	-	-	-	DUF359
HKD1_k127_1545017_12	368407.Memar_2243	6.08e-20	91.0	COG2093@1|root,arCOG04077@2157|Archaea,2Y0D6@28890|Euryarchaeota,2NA1J@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription elongation factor Spt4	spt4	-	2.7.7.6	ko:K03050	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Spt4
HKD1_k127_1545017_6	1041930.Mtc_0059	2.807e-67	236.0	COG1095@1|root,arCOG00675@2157|Archaea,2XT6U@28890|Euryarchaeota,2N9GJ@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM DNA-directed RNA polymerase	-	-	2.7.7.6	ko:K03049	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	S1,SHS2_Rpb7-N
HKD1_k127_1559261_3	1041930.Mtc_0700	8.232e-20	91.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_1559261_0	269797.Mbar_A0495	4.989e-101	343.0	COG0303@1|root,arCOG00216@2157|Archaea,2XT05@28890|Euryarchaeota,2N9B5@224756|Methanomicrobia	224756|Methanomicrobia	H	Probable molybdopterin binding domain	moeA-2	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD1_k127_1559261_1	269797.Mbar_A0178	1.197e-94	321.0	COG2038@1|root,arCOG04272@2157|Archaea,2XTPU@28890|Euryarchaeota,2N9K1@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1559261_2	269797.Mbar_A2944	7.19e-31	129.0	COG0628@1|root,arCOG02642@2157|Archaea,2XXF0@28890|Euryarchaeota,2N9N3@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_1629530_4	379066.GAU_0188	1.001e-20	102.0	COG0553@1|root,COG0553@2|Bacteria,1ZV08@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
HKD1_k127_1629530_1	909663.KI867150_gene533	1.678e-52	192.0	COG2885@1|root,COG2885@2|Bacteria,1R1YC@1224|Proteobacteria,43DCH@68525|delta/epsilon subdivisions,2WTAX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_1629530_0	909663.KI867150_gene532	3.904e-73	271.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1629530_3	323261.Noc_0666	9.021e-24	104.0	2BRR8@1|root,32KR0@2|Bacteria,1RHZI@1224|Proteobacteria,1SBZ8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1636804_0	297246.lpp1648	5.7e-67	237.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,1SVID@1236|Gammaproteobacteria,1JD85@118969|Legionellales	118969|Legionellales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_1639503_5	1033734.CAET01000042_gene423	0.0001403	55.0	COG0726@1|root,COG2247@1|root,COG0726@2|Bacteria,COG2247@2|Bacteria,1V827@1239|Firmicutes,4HGM9@91061|Bacilli,1ZFYZ@1386|Bacillus	91061|Bacilli	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_1639503_4	1094980.Mpsy_0875	9.259e-15	81.0	COG3612@1|root,arCOG04418@2157|Archaea,2XXT8@28890|Euryarchaeota,2NA4A@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2240)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2240
HKD1_k127_1639503_2	1110502.TMO_0484	3.948e-67	245.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_1639503_0	247490.KSU1_D0969	5.222e-102	349.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Dak2,DegV,Radical_SAM
HKD1_k127_1639503_1	368407.Memar_1634	4.107e-72	250.0	COG2102@1|root,arCOG00035@2157|Archaea,2XTNJ@28890|Euryarchaeota,2N9QU@224756|Methanomicrobia	224756|Methanomicrobia	E	Diphthamide synthase	-	-	6.3.1.14	ko:K06927	-	-	R03613	RC00358	ko00000,ko01000,ko03012	-	-	-	Diphthami_syn_2
HKD1_k127_1639503_3	368407.Memar_1633	4.482e-39	152.0	COG0518@1|root,arCOG00090@2157|Archaea,2Y5MH@28890|Euryarchaeota	28890|Euryarchaeota	F	PFAM Glutamine amidotransferase class-I	-	-	-	-	-	-	-	-	-	-	-	-	GATase
HKD1_k127_1664173_18	1242864.D187_001476	4.215e-31	126.0	COG0659@1|root,COG0663@1|root,COG0659@2|Bacteria,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,42MR0@68525|delta/epsilon subdivisions,2WP23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	transferase hexapeptide	-	-	-	ko:K02617,ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	Hexapep
HKD1_k127_1664173_1	192952.MM_1618	6.361e-154	492.0	COG0136@1|root,arCOG00494@2157|Archaea,2XTKH@28890|Euryarchaeota,2N920@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Semialdehyde dehydrogenase NAD - binding	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_1664173_6	192952.MM_1726	1.734e-93	316.0	COG0535@1|root,arCOG00938@2157|Archaea,2Y8D0@28890|Euryarchaeota,2N9ER@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_1664173_14	1094980.Mpsy_2494	3.949e-41	157.0	COG1522@1|root,arCOG01629@2157|Archaea,2Y851@28890|Euryarchaeota,2N9XY@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein AsnC Lrp family	-	-	-	ko:K22225	-	-	-	-	ko00000	-	-	-	HTH_AsnC-type
HKD1_k127_1664173_20	694430.Natoc_2424	1.405e-19	91.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZ0C@28890|Euryarchaeota,23WWM@183963|Halobacteria	183963|Halobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	trxA1	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_1664173_5	1094980.Mpsy_1868	9.641e-97	326.0	COG1236@1|root,arCOG00545@2157|Archaea,2XW9F@28890|Euryarchaeota,2N9EJ@224756|Methanomicrobia	224756|Methanomicrobia	J	Metallo-beta-lactamase superfamily	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_1664173_16	1041930.Mtc_2275	3.709e-36	140.0	COG1727@1|root,arCOG00780@2157|Archaea,2XZ6R@28890|Euryarchaeota,2N9UH@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL18 family	rpl18e	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
HKD1_k127_1664173_15	1041930.Mtc_2276	1.318e-40	154.0	COG0102@1|root,arCOG04242@2157|Archaea,2XWN6@28890|Euryarchaeota,2N9Q5@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_1664173_13	192952.MM_1757	2.634e-47	173.0	COG0088@1|root,arCOG04243@2157|Archaea,2XWK0@28890|Euryarchaeota,2N9S9@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS9 family	rps9	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_1664173_19	269797.Mbar_A1425	7.101e-22	95.0	COG1644@1|root,arCOG04244@2157|Archaea,2Y03I@28890|Euryarchaeota,2NA2D@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
HKD1_k127_1664173_21	694440.JOMF01000005_gene40	3.649e-17	82.0	COG1758@1|root,arCOG01268@2157|Archaea,2XZSW@28890|Euryarchaeota,2NA2R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoK	-	2.7.7.6	ko:K03055	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb6
HKD1_k127_1664173_7	1041930.Mtc_2281	1.155e-89	299.0	COG0052@1|root,arCOG04245@2157|Archaea,2XTHM@28890|Euryarchaeota,2N9BZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_1664173_8	269797.Mbar_A1422	5.699e-87	294.0	COG1355@1|root,arCOG01728@2157|Archaea,2XVYU@28890|Euryarchaeota,2N9H3@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD1_k127_1664173_10	192952.MM_1762	2.509e-56	209.0	COG1577@1|root,arCOG01028@2157|Archaea,2XSUB@28890|Euryarchaeota,2N96Q@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_1664173_9	1041930.Mtc_2284	2.624e-65	231.0	COG1608@1|root,arCOG00860@2157|Archaea,2XSUI@28890|Euryarchaeota,2N9PA@224756|Methanomicrobia	224756|Methanomicrobia	I	Catalyzes the formation of isopentenyl diphosphate (IPP), the building block of all isoprenoids	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_1664173_2	1094980.Mpsy_0885	2.201e-116	385.0	COG1304@1|root,arCOG00613@2157|Archaea,2XT6H@28890|Euryarchaeota,2N94G@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP)	fni	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	FMN_dh
HKD1_k127_1664173_0	304371.MCP_1636	6.083e-202	637.0	COG0595@1|root,arCOG00546@2157|Archaea,2XTBT@28890|Euryarchaeota,2N9D4@224756|Methanomicrobia	224756|Methanomicrobia	J	An RNase that has 5'-3' exonuclease activity. May be involved in RNA degradation	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD1_k127_1664173_4	269797.Mbar_A1417	2.331e-110	366.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_1664173_23	1094980.Mpsy_2820	7.847e-09	58.0	arCOG02716@1|root,arCOG02716@2157|Archaea,2Y57Q@28890|Euryarchaeota,2NBDW@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1664173_22	1041930.Mtc_2243	6.403e-13	72.0	arCOG06692@1|root,arCOG06692@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1664173_11	123214.PERMA_0905	1.958e-52	188.0	COG1832@1|root,COG1832@2|Bacteria,2G57Q@200783|Aquificae	200783|Aquificae	S	CoA-binding domain protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_1664173_12	269797.Mbar_A0394	3.57e-51	192.0	COG0142@1|root,arCOG01727@2157|Archaea,2XVFJ@28890|Euryarchaeota,2N9MT@224756|Methanomicrobia	224756|Methanomicrobia	H	Polyprenyl synthetase	-	GO:0003674,GO:0003824,GO:0004659,GO:0016740,GO:0016765	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_1664173_3	269797.Mbar_A0393	1.723e-113	378.0	arCOG00942@1|root,arCOG00942@2157|Archaea,2Y332@28890|Euryarchaeota,2NAJ6@224756|Methanomicrobia	224756|Methanomicrobia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HKD1_k127_1664173_17	521011.Mpal_0638	1.192e-33	133.0	COG0840@1|root,arCOG03007@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_1675996_1	243274.THEMA_03355	2.581e-112	372.0	COG0282@1|root,COG0282@2|Bacteria,2GC1D@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD1_k127_1675996_2	1265505.ATUG01000001_gene4352	1.155e-99	332.0	COG2513@1|root,COG2513@2|Bacteria,1N4VT@1224|Proteobacteria,42NZ1@68525|delta/epsilon subdivisions,2WNX5@28221|Deltaproteobacteria,2MPFE@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Isocitrate lyase family	prpB	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD1_k127_1675996_3	693661.Arcve_0209	2.738e-80	278.0	COG1793@1|root,arCOG01347@2157|Archaea,2Y42Y@28890|Euryarchaeota	28890|Euryarchaeota	H	DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD1_k127_1675996_4	1121929.KB898664_gene1493	2.642e-48	183.0	COG1273@1|root,COG1273@2|Bacteria,1TSY5@1239|Firmicutes,4HC5V@91061|Bacilli,471Q2@74385|Gracilibacillus	91061|Bacilli	L	Ku70 and Ku80 are 70kDa and 80kDa subunits of the Lupus Ku autoantigen	ku	GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0097159,GO:1901363	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD1_k127_1675996_0	211165.AJLN01000034_gene2724	1.648e-126	410.0	COG1064@1|root,COG1064@2|Bacteria,1G327@1117|Cyanobacteria,1JIY9@1189|Stigonemataceae	1117|Cyanobacteria	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1690666_0	192952.MM_0813	5.561e-56	200.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota,2NANV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
HKD1_k127_1690666_1	192952.MM_0813	4.507e-33	134.0	COG1683@1|root,arCOG04848@2157|Archaea,2XV91@28890|Euryarchaeota,2NANV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
HKD1_k127_1690666_2	1408287.AXUR01000003_gene2019	2.32e-07	53.0	COG1917@1|root,COG1917@2|Bacteria,37AQB@32066|Fusobacteria	32066|Fusobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	CMD,Cupin_2
HKD1_k127_173396_2	351160.RCIX1846	9.265e-86	291.0	COG1474@1|root,arCOG00467@2157|Archaea,2XTRB@28890|Euryarchaeota,2N9C7@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in regulation of DNA replication	cdc6-2	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16,AAA_22,Cdc6_C
HKD1_k127_173396_3	323259.Mhun_2982	5.083e-72	253.0	COG0581@1|root,arCOG00168@2157|Archaea,2Y8DS@28890|Euryarchaeota,2N9FR@224756|Methanomicrobia	224756|Methanomicrobia	P	phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_173396_5	456442.Mboo_1918	2.306e-67	244.0	COG0581@1|root,arCOG00168@2157|Archaea,2Y8DS@28890|Euryarchaeota,2N9FR@224756|Methanomicrobia	224756|Methanomicrobia	P	phosphate ABC transporter, inner membrane subunit PstA	-	-	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_173396_1	269797.Mbar_A0366	2.296e-130	431.0	COG0063@1|root,arCOG00018@2157|Archaea,2XU4W@28890|Euryarchaeota,2N9DZ@224756|Methanomicrobia	224756|Methanomicrobia	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase,YjeF_N
HKD1_k127_173396_6	374847.Kcr_1041	8.787e-43	160.0	COG0315@1|root,arCOG01530@2157|Archaea	2157|Archaea	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD1_k127_173396_0	1094980.Mpsy_2086	8.557e-167	534.0	COG0180@1|root,arCOG01887@2157|Archaea,2XSVC@28890|Euryarchaeota,2N997@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM aminoacyl-tRNA synthetase class Ib	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A1374	tRNA-synt_1b
HKD1_k127_173396_7	304371.MCP_0085	2.575e-36	141.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,2NBJG@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_173396_9	693661.Arcve_0443	3.144e-10	63.0	COG2104@1|root,arCOG00535@2157|Archaea	2157|Archaea	H	Sulfur transfer protein involved in thiamine biosynthesis	samp2	GO:0003674,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019538,GO:0031386,GO:0032446,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0070647,GO:0071704,GO:1901564	2.8.1.15	ko:K03154,ko:K21947	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	ThiS
HKD1_k127_173396_8	192952.MM_1826	7.609e-36	147.0	arCOG03479@1|root,arCOG03479@2157|Archaea,2Y0TG@28890|Euryarchaeota,2NB1D@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_173396_4	1094980.Mpsy_1889	2.561e-69	254.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
HKD1_k127_1757514_4	644283.Micau_1690	0.0001172	44.0	COG0778@1|root,COG0778@2|Bacteria,2I8P3@201174|Actinobacteria,4D9HC@85008|Micromonosporales	201174|Actinobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_1757514_3	388399.SSE37_18592	2.496e-05	49.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2U7H5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	COG2335, Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_1757514_0	323259.Mhun_0599	1.328e-31	130.0	COG0071@1|root,arCOG01832@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_1757514_2	1455608.JDTH01000002_gene1473	3.652e-06	51.0	arCOG04820@1|root,arCOG04820@2157|Archaea,2XX4W@28890|Euryarchaeota,23VU2@183963|Halobacteria	183963|Halobacteria	T	PFAM SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
HKD1_k127_177836_4	1094980.Mpsy_2148	1.796e-74	255.0	COG2000@1|root,arCOG00295@2157|Archaea,2XUQ6@28890|Euryarchaeota,2NA2V@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Fe-S cluster domain protein	-	-	-	ko:K06939	-	-	-	-	ko00000	-	-	-	FeS
HKD1_k127_177836_3	1094980.Mpsy_2147	2.049e-107	352.0	COG0378@1|root,arCOG01231@2157|Archaea,2XUHE@28890|Euryarchaeota,2N9QP@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM cobalamin synthesis protein P47K	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD1_k127_177836_2	1094980.Mpsy_2146	8.767e-109	357.0	COG1136@1|root,arCOG03228@2157|Archaea,2XVM5@28890|Euryarchaeota,2N9ID@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_177836_1	1094980.Mpsy_2145	4.015e-131	432.0	COG0498@1|root,arCOG01434@2157|Archaea,2XUJC@28890|Euryarchaeota,2N9BY@224756|Methanomicrobia	224756|Methanomicrobia	H	Specifically catalyzes the beta-elimination of phosphate from L-phosphoserine and the beta-addition of sulfite to the dehydroalanine intermediate to produce L-cysteate	-	-	2.5.1.76	ko:K15527	-	-	-	-	ko00000,ko01000	-	-	-	PALP
HKD1_k127_177836_0	386456.JQKN01000004_gene217	5.515e-176	574.0	COG1950@1|root,arCOG09731@2157|Archaea,2Y2F9@28890|Euryarchaeota,23PAN@183925|Methanobacteria	183925|Methanobacteria	S	Mycobacterial 4 TMS phage holin, superfamily IV	-	-	-	ko:K08972	-	-	-	-	ko00000	-	-	-	Phage_holin_4_2,Phosphodiest
HKD1_k127_177836_8	269797.Mbar_A1759	6.283e-08	61.0	arCOG04981@1|root,arCOG04981@2157|Archaea,2Y42Q@28890|Euryarchaeota,2NB1S@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_177836_5	666685.R2APBS1_1019	1.964e-28	119.0	COG3296@1|root,COG3296@2|Bacteria,1N8TC@1224|Proteobacteria,1SEZY@1236|Gammaproteobacteria,1X76D@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4870)	-	-	-	ko:K09940	-	-	-	-	ko00000	-	-	-	DUF4870
HKD1_k127_177836_7	237368.SCABRO_01684	9.138e-13	79.0	COG0170@1|root,COG0560@1|root,COG0170@2|Bacteria,COG0560@2|Bacteria,2J1H5@203682|Planctomycetes	203682|Planctomycetes	I	Phosphoserine phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_177929_0	269797.Mbar_A1908	2.479e-19	102.0	arCOG03980@1|root,arCOG03980@2157|Archaea	2157|Archaea	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_181933_0	1041930.Mtc_1540	1.915e-212	674.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,2N924@224756|Methanomicrobia	224756|Methanomicrobia	V	PFAM PilT protein domain protein	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
HKD1_k127_181933_3	368407.Memar_0430	2.6e-43	162.0	COG0184@1|root,arCOG04185@2157|Archaea,2XWKV@28890|Euryarchaeota,2N9S2@224756|Methanomicrobia	224756|Methanomicrobia	J	ribosomal protein S15	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
HKD1_k127_181933_2	351160.LRC57	2.087e-102	347.0	COG0608@1|root,arCOG00427@2157|Archaea,2XW5A@28890|Euryarchaeota,2N9D2@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHA1
HKD1_k127_181933_4	192952.MM_0212	6.674e-08	57.0	arCOG01354@1|root,arCOG01354@2157|Archaea	2157|Archaea	-	-	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0044424,GO:0044464	-	-	-	-	-	-	-	-	-	-	Pcc1
HKD1_k127_181933_1	1094980.Mpsy_2683	8.723e-124	404.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
HKD1_k127_1850523_5	742726.HMPREF9448_01099	0.0004277	49.0	COG1621@1|root,COG1621@2|Bacteria,4PHNR@976|Bacteroidetes,2FRDN@200643|Bacteroidia	976|Bacteroidetes	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_66,VCBS
HKD1_k127_1850523_3	269797.Mbar_A3650	3.992e-31	126.0	COG1308@1|root,arCOG04061@2157|Archaea,2XXYV@28890|Euryarchaeota,2NA0G@224756|Methanomicrobia	224756|Methanomicrobia	J	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
HKD1_k127_1850523_0	1094980.Mpsy_2206	8.463e-172	557.0	COG1078@1|root,COG3465@1|root,arCOG00725@2157|Archaea,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_1850523_4	1041930.Mtc_0313	6.232e-21	104.0	COG1865@1|root,arCOG01870@2157|Archaea,2XUDZ@28890|Euryarchaeota,2N9UT@224756|Methanomicrobia	224756|Methanomicrobia	H	Cysteine-rich small domain	cbiZ	-	3.5.1.90	ko:K08260	ko00860,ko01100,map00860,map01100	-	R05226	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	CbiZ,zf-like
HKD1_k127_1850523_2	273063.STK_06690	2.917e-35	146.0	COG0584@1|root,arCOG00701@2157|Archaea,2XQKB@28889|Crenarchaeota	28889|Crenarchaeota	C	PFAM Glycerophosphoryl diester phosphodiesterase	-	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD1_k127_1850523_1	693661.Arcve_1020	1.487e-147	475.0	COG1103@1|root,arCOG00091@2157|Archaea,2XU3S@28890|Euryarchaeota,24619@183980|Archaeoglobi	183980|Archaeoglobi	J	Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys))	-	-	2.5.1.73	ko:K06868	ko00970,map00970	-	R08577	RC02948	ko00000,ko00001,ko01000,ko03016	-	-	-	SepSecS
HKD1_k127_1887115_0	552811.Dehly_0879	4.75e-155	500.0	COG0004@1|root,COG0004@2|Bacteria,2G5N8@200795|Chloroflexi,34D2M@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Ammonium Transporter Family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_1887115_1	243164.DET1124	4.037e-38	145.0	COG0347@1|root,COG0347@2|Bacteria,2G9JD@200795|Chloroflexi,34DDF@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Nitrogen regulatory protein P-II	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_1887115_3	1094980.Mpsy_0216	2.37e-07	53.0	COG3039@1|root,arCOG06508@2157|Archaea	2157|Archaea	L	transposase activity	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_1887115_2	1094980.Mpsy_0033	1.982e-21	95.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_1887115_4	1094980.Mpsy_0033	0.0001126	50.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_1909031_1	521011.Mpal_1635	1.526e-45	171.0	COG1733@1|root,arCOG01057@2157|Archaea,2XZIB@28890|Euryarchaeota,2N9X0@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM helix-turn-helix HxlR type	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_1909031_3	1094980.Mpsy_0823	5.661e-23	99.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2NAE5@224756|Methanomicrobia	224756|Methanomicrobia	O	Peptidase family M48	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_1909031_2	387631.Asulf_01598	1.242e-26	113.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,246AM@183980|Archaeoglobi	183980|Archaeoglobi	C	Formylmethanofuran dehydrogenase subunit D	-	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
HKD1_k127_1909031_0	1094980.Mpsy_1028	3.897e-167	536.0	COG0119@1|root,arCOG02093@2157|Archaea,2XVVR@28890|Euryarchaeota,2N9C3@224756|Methanomicrobia	224756|Methanomicrobia	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_1909031_4	368407.Memar_0924	3.97e-06	49.0	arCOG00526@1|root,arCOG00526@2157|Archaea,2Y3VB@28890|Euryarchaeota,2NAV4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD1_k127_195312_0	523850.TON_1432	3.054e-174	558.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD1_k127_195312_1	521045.Kole_1432	9.1e-77	267.0	COG0549@1|root,COG0549@2|Bacteria,2GCB0@200918|Thermotogae	200918|Thermotogae	E	Belongs to the carbamate kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_195312_2	269797.Mbar_A2604	1.628e-74	262.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,2NAN4@224756|Methanomicrobia	224756|Methanomicrobia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_2005035_1	1094980.Mpsy_1283	5.328e-32	132.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2N9SR@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
HKD1_k127_2005035_0	1094980.Mpsy_2659	1.243e-223	706.0	COG0008@1|root,arCOG04302@2157|Archaea,2XSYV@28890|Euryarchaeota,2N9CR@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD1_k127_2005035_2	1267534.KB906755_gene4810	1.232e-13	74.0	2CA7I@1|root,30E5G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2005873_0	768706.Desor_5502	4.921e-10	60.0	COG1278@1|root,COG1278@2|Bacteria,1VBBH@1239|Firmicutes,24QK9@186801|Clostridia,262K0@186807|Peptococcaceae	186801|Clostridia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD1_k127_2016284_0	632335.Calkr_0531	1.936e-297	918.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia,42J79@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
HKD1_k127_2016284_2	1122132.AQYH01000003_gene3069	1.185e-06	54.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,4B70K@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_2016284_1	269797.Mbar_A2016	2.666e-10	70.0	arCOG03256@1|root,arCOG03256@2157|Archaea,2Y6XR@28890|Euryarchaeota,2NAP3@224756|Methanomicrobia	224756|Methanomicrobia	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
HKD1_k127_2049082_5	192952.MM_1593	3.071e-48	183.0	COG1498@1|root,arCOG01923@2157|Archaea,2XUEA@28890|Euryarchaeota,2N9S7@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Pre-mRNA processing ribonucleoprotein, binding	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
HKD1_k127_2049082_8	593750.Metfor_1876	5.049e-27	115.0	COG4738@1|root,arCOG04377@2157|Archaea,2Y0VV@28890|Euryarchaeota,2N9YZ@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2049082_2	1094980.Mpsy_1495	6.561e-160	511.0	COG0206@1|root,arCOG02201@2157|Archaea,2XTMW@28890|Euryarchaeota,2N926@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	-	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin,tRNA_deacylase
HKD1_k127_2049082_7	304371.MCP_2599	4.665e-28	116.0	COG3388@1|root,arCOG01345@2157|Archaea,2XXVY@28890|Euryarchaeota,2N9YC@224756|Methanomicrobia	224756|Methanomicrobia	K	protein conserved in archaea	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2049082_6	387631.Asulf_01636	1.153e-41	170.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,246K0@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD1_k127_2049082_3	1184251.TCELL_0642	4.567e-84	287.0	COG1533@1|root,arCOG01290@2157|Archaea,2XPQ6@28889|Crenarchaeota	28889|Crenarchaeota	L	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_2049082_9	179408.Osc7112_0245	7.994e-12	76.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
HKD1_k127_2049082_0	335543.Sfum_0673	1.109e-241	750.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_2049082_1	1366050.N234_10425	2.711e-225	706.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2WHH3@28216|Betaproteobacteria,1KIP3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_2049082_4	211114.JOEF01000006_gene2562	4.228e-75	259.0	COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria,4DYCA@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2178947_0	269797.Mbar_A0706	8.747e-101	338.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,2N90Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2178947_1	269797.Mbar_A0705	1.49e-34	137.0	COG4029@1|root,arCOG04901@2157|Archaea,2XZQS@28890|Euryarchaeota,2N9W1@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2102)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2102
HKD1_k127_21953_0	224324.aq_1006	5.758e-06	60.0	COG0419@1|root,COG0419@2|Bacteria,2G46J@200783|Aquificae	200783|Aquificae	L	PFAM SMC domain protein	-	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_21,AAA_23,Rad50_zn_hook,SMC_N,SbcCD_C
HKD1_k127_2230474_3	32057.KB217478_gene6068	1.707e-10	71.0	COG1413@1|root,COG1413@2|Bacteria,1G6AT@1117|Cyanobacteria	1117|Cyanobacteria	C	PFAM Leucine rich repeat variant	-	-	-	-	-	-	-	-	-	-	-	-	LRV
HKD1_k127_2230474_0	192952.MM_2286	9.078e-26	118.0	COG1503@1|root,arCOG01743@2157|Archaea,2XUJ5@28890|Euryarchaeota,2N9TU@224756|Methanomicrobia	224756|Methanomicrobia	J	eRF1 domain 2	-	-	-	-	-	-	-	-	-	-	-	-	eRF1_2
HKD1_k127_2230474_2	745014.OMB55_00014410	5.377e-18	91.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,1S2JU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
HKD1_k127_2230474_1	368407.Memar_1631	3.344e-19	89.0	COG1531@1|root,arCOG01302@2157|Archaea	2157|Archaea	S	Belongs to the UPF0248 family	-	-	-	ko:K09715	-	-	-	-	ko00000	-	-	-	DUF504
HKD1_k127_223116_1	192952.MM_2850	1.704e-85	300.0	COG4591@1|root,arCOG02313@2157|Archaea,2Y3AK@28890|Euryarchaeota,2NAK5@224756|Methanomicrobia	224756|Methanomicrobia	M	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_223116_2	192952.MM_0091	3.549e-78	275.0	COG4591@1|root,arCOG02314@2157|Archaea,2Y2DB@28890|Euryarchaeota,2NA6V@224756|Methanomicrobia	224756|Methanomicrobia	P	MacB-like periplasmic core domain	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_223116_0	383372.Rcas_2659	4.1e-322	1009.0	COG0474@1|root,COG0474@2|Bacteria,2G85U@200795|Chloroflexi,376M7@32061|Chloroflexia	32061|Chloroflexia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	-	-	-	-	-	-	-	-	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_223116_8	1304875.JAFZ01000001_gene1521	2.529e-18	89.0	2EGUV@1|root,33AM0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_223116_6	1094980.Mpsy_0253	1.411e-28	119.0	arCOG04911@1|root,arCOG04911@2157|Archaea,2Y1AD@28890|Euryarchaeota,2NAZV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
HKD1_k127_223116_3	13333.ERN09428	4.863e-49	183.0	COG1535@1|root,2QQB1@2759|Eukaryota,37IJ0@33090|Viridiplantae,3GBAF@35493|Streptophyta	35493|Streptophyta	Q	nicotinamidase activity	-	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008936,GO:0009117,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0019362,GO:0019637,GO:0019674,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0071704,GO:0072524,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD1_k127_223116_4	572546.Arcpr_0555	1.548e-45	171.0	COG5014@1|root,arCOG05120@2157|Archaea	2157|Archaea	S	PFAM Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_223116_5	591019.Shell_0344	4.334e-31	130.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_223116_7	192952.MM_3077	3.446e-23	104.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia	224756|Methanomicrobia	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_2232998_1	330779.Saci_0356	0.0006314	45.0	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_2232998_0	593750.Metfor_2788	1.733e-25	108.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,2NA7P@224756|Methanomicrobia	224756|Methanomicrobia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_2247586_5	269797.Mbar_A0942	8.532e-87	292.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_2247586_6	1094980.Mpsy_1810	1.616e-82	281.0	COG0084@1|root,arCOG00891@2157|Archaea,2XV9Y@28890|Euryarchaeota,2NADU@224756|Methanomicrobia	224756|Methanomicrobia	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_2247586_7	269797.Mbar_A0207	1.664e-69	241.0	COG1432@1|root,arCOG02408@2157|Archaea,2XX7V@28890|Euryarchaeota,2N9P5@224756|Methanomicrobia	224756|Methanomicrobia	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD1_k127_2247586_9	192952.MM_0682	3.377e-33	138.0	COG0705@1|root,arCOG01768@2157|Archaea,2XTJH@28890|Euryarchaeota,2N9X9@224756|Methanomicrobia	224756|Methanomicrobia	E	Rhomboid family	-	-	-	ko:K07059	-	-	-	-	ko00000	-	-	-	Rhomboid,zf-AN1
HKD1_k127_2247586_2	1094980.Mpsy_3165	1.841e-151	494.0	COG0433@1|root,arCOG03732@1|root,arCOG00280@2157|Archaea,arCOG03732@2157|Archaea,2Y7MA@28890|Euryarchaeota,2NA8T@224756|Methanomicrobia	224756|Methanomicrobia	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87,HAS-barrel
HKD1_k127_2247586_1	456442.Mboo_1539	1.854e-158	506.0	COG1902@1|root,arCOG00615@2157|Archaea,2XT27@28890|Euryarchaeota,2N9SK@224756|Methanomicrobia	224756|Methanomicrobia	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD1_k127_2247586_8	565033.GACE_0473	3.466e-48	176.0	COG1881@1|root,arCOG04702@2157|Archaea,2XXMX@28890|Euryarchaeota,2470F@183980|Archaeoglobi	183980|Archaeoglobi	S	PFAM PEBP family protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_2247586_3	309803.CTN_0372	1.164e-142	467.0	COG1012@1|root,COG1012@2|Bacteria,2GCJA@200918|Thermotogae	200918|Thermotogae	C	PFAM Aldehyde dehydrogenase	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_2247586_0	1094980.Mpsy_0873	5.499e-179	574.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9CA@224756|Methanomicrobia	224756|Methanomicrobia	E	D-isomer specific 2-hydroxyacid dehydrogenase catalytic	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD1_k127_2247586_4	269797.Mbar_A1101	8.852e-88	296.0	COG1891@1|root,arCOG04482@2157|Archaea,2XUBQ@28890|Euryarchaeota,2N952@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of 4-(hydroxymethyl)-2- furancarboxaldehyde phosphate (4-HFC-P) from two molecules of glyceraldehyde-3-P (GA-3-P)	mfnB	-	4.2.3.153	ko:K09733	ko00680,map00680	-	R10935	RC03315	ko00000,ko00001,ko01000	-	-	-	4HFCP_synth
HKD1_k127_2247586_10	304371.MCP_2811	1.696e-15	78.0	COG1411@1|root,arCOG00616@2157|Archaea,2XYJ0@28890|Euryarchaeota,2N9PP@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_2249209_0	402777.KB235903_gene694	7.028e-43	165.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_2249209_1	1094980.Mpsy_1243	1.202e-10	65.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_225165_5	1094980.Mpsy_3095	7.083e-93	317.0	COG1867@1|root,arCOG01219@2157|Archaea,2XTUF@28890|Euryarchaeota,2N97Q@224756|Methanomicrobia	224756|Methanomicrobia	J	Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups	trm1	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
HKD1_k127_225165_2	1094980.Mpsy_1732	7.717e-122	404.0	COG1916@1|root,arCOG02142@2157|Archaea,2XTNE@28890|Euryarchaeota,2N97A@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM TraB family protein	-	-	-	-	-	-	-	-	-	-	-	-	TraB
HKD1_k127_225165_4	269797.Mbar_A0978	2.16e-99	336.0	COG0517@1|root,arCOG00607@2157|Archaea,2XTE5@28890|Euryarchaeota,2N998@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HKD1_k127_225165_8	673860.AciM339_1293	1.514e-41	159.0	COG0235@1|root,arCOG04226@2157|Archaea,2XX1T@28890|Euryarchaeota,3F30B@33867|unclassified Euryarchaeota	28890|Euryarchaeota	G	PFAM Class II Aldolase	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1249	Aldolase_II
HKD1_k127_225165_6	273068.TTE0824	2.294e-74	273.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,42FS7@68295|Thermoanaerobacterales	186801|Clostridia	M	Serine protease with a broad substrate specificity	-	-	-	ko:K13276,ko:K17734	-	-	-	-	ko00000,ko01000,ko01002,ko03110	-	-	-	CarboxypepD_reg,Cu_amine_oxidN1,Inhibitor_I9,LRR_5,PPC,Peptidase_S8
HKD1_k127_225165_10	1307436.PBF_24523	1.45e-26	121.0	COG2897@1|root,COG2897@2|Bacteria,1TRYA@1239|Firmicutes,4HAQA@91061|Bacilli,1ZANF@1386|Bacillus	91061|Bacilli	P	sulfurtransferase	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_225165_9	406327.Mevan_1287	4.485e-33	145.0	arCOG02527@1|root,arCOG03439@1|root,arCOG02527@2157|Archaea,arCOG03439@2157|Archaea,2XXWR@28890|Euryarchaeota,23RJF@183939|Methanococci	183939|Methanococci	S	PFAM periplasmic copper-binding	-	-	-	-	-	-	-	-	-	-	-	-	NosD
HKD1_k127_225165_11	1094980.Mpsy_2097	6.959e-26	117.0	COG0526@1|root,COG0785@1|root,arCOG01972@2157|Archaea,arCOG02404@2157|Archaea,2Y7HT@28890|Euryarchaeota,2NA19@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
HKD1_k127_225165_0	192952.MM_1279	7.869e-167	533.0	COG0269@1|root,arCOG00103@2157|Archaea,2XUYW@28890|Euryarchaeota,2N9CN@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin	fae-hps	-	4.1.2.43,4.2.1.147	ko:K13812	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R08058	RC00421,RC00422,RC01583,RC01795	ko00000,ko00001,ko00002,ko01000	-	-	-	Fae,OMPdecase
HKD1_k127_225165_3	192952.MM_2378	4.211e-102	343.0	COG2237@1|root,arCOG04151@2157|Archaea,2XTV5@28890|Euryarchaeota,2N948@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
HKD1_k127_225165_7	386456.JQKN01000001_gene1851	1.656e-66	237.0	COG2218@1|root,arCOG00098@2157|Archaea,2XVBM@28890|Euryarchaeota	28890|Euryarchaeota	C	PFAM glutamate synthase alpha subunit	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
HKD1_k127_225165_1	1094980.Mpsy_1278	1.12e-126	415.0	COG0206@1|root,arCOG02202@2157|Archaea,2XTM7@28890|Euryarchaeota,2NB7I@224756|Methanomicrobia	224756|Methanomicrobia	D	Involved in cell shape control	cetZ	-	-	ko:K22222	-	-	-	-	ko00000,ko04812	-	-	-	Tubulin
HKD1_k127_2267505_1	192952.MM_2380	3.318e-105	354.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
HKD1_k127_2267505_2	1094980.Mpsy_1197	3.909e-99	329.0	COG1497@1|root,arCOG04399@2157|Archaea,2XU16@28890|Euryarchaeota,2N9I6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein, Crp	-	-	-	ko:K07730	-	-	-	-	ko00000,ko03000	-	-	-	HTH_24,MarR_2
HKD1_k127_2267505_5	269797.Mbar_A2037	2.047e-48	178.0	COG4860@1|root,arCOG04366@2157|Archaea,2XYAX@28890|Euryarchaeota,2N9RU@224756|Methanomicrobia	224756|Methanomicrobia	K	ArsR transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ArsR
HKD1_k127_2267505_0	351160.RCIX2365	1.463e-311	964.0	COG1782@1|root,arCOG00543@2157|Archaea,2XTIM@28890|Euryarchaeota,2N99U@224756|Methanomicrobia	224756|Methanomicrobia	S	KH, type 1, domain	-	-	-	ko:K07041	-	-	-	-	ko00000	-	-	-	Beta-Casp,KH_2,KH_7,Lactamase_B,Lactamase_B_6,RMMBL
HKD1_k127_2267505_3	1094980.Mpsy_2881	1.333e-76	261.0	COG0638@1|root,arCOG00970@2157|Archaea,2XUIZ@28890|Euryarchaeota,2N9GY@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmB	-	3.4.25.1	ko:K03433	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome
HKD1_k127_2267505_4	1094980.Mpsy_0965	6.955e-59	214.0	COG1967@1|root,arCOG02177@2157|Archaea,2XT8V@28890|Euryarchaeota,2N9NX@224756|Methanomicrobia	224756|Methanomicrobia	S	Membrane protein of unknown function DUF63	-	-	-	-	-	-	-	-	-	-	-	-	DUF63
HKD1_k127_2267505_6	1455608.JDTH01000002_gene1936	5.767e-08	57.0	COG1855@1|root,arCOG04116@2157|Archaea,2XSZY@28890|Euryarchaeota,23S5U@183963|Halobacteria	183963|Halobacteria	V	ATPase (PilT family)	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,PIN,T2SSE
HKD1_k127_2271459_5	386456.JQKN01000014_gene3127	6.021e-70	244.0	COG3503@1|root,arCOG04370@2157|Archaea,2XWYK@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624
HKD1_k127_2271459_0	589924.Ferp_2119	6.001e-186	597.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,245PX@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM Chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_2271459_8	368407.Memar_1957	6.781e-41	158.0	COG2890@1|root,arCOG00109@2157|Archaea,2XWJZ@28890|Euryarchaeota,2N9RR@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM methyltransferase small	-	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HKD1_k127_2271459_7	1094980.Mpsy_2166	4.098e-42	158.0	arCOG03354@1|root,arCOG03353@2157|Archaea,2Y3N8@28890|Euryarchaeota,2NAX4@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1699)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1699
HKD1_k127_2271459_4	304371.MCP_0045	3.381e-87	297.0	COG1084@1|root,arCOG00352@2157|Archaea,2XU5R@28890|Euryarchaeota,2N941@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM small GTP-binding protein	-	-	-	ko:K06943	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	NOG1
HKD1_k127_2271459_9	1094980.Mpsy_0889	7.411e-11	66.0	COG3277@1|root,arCOG02466@2157|Archaea,2Y1T0@28890|Euryarchaeota,2NA4E@224756|Methanomicrobia	224756|Methanomicrobia	J	Gar1/Naf1 RNA binding region	-	-	-	ko:K07569	-	-	-	-	ko00000,ko03009	-	-	-	Gar1
HKD1_k127_2271459_1	1094980.Mpsy_0890	1.516e-182	574.0	COG1405@1|root,arCOG01981@2157|Archaea,2XT0Z@28890|Euryarchaeota,2N96C@224756|Methanomicrobia	224756|Methanomicrobia	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	tfb	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
HKD1_k127_2271459_6	269797.Mbar_A1332	1.125e-55	205.0	COG0101@1|root,arCOG04449@2157|Archaea,2XTH5@28890|Euryarchaeota,2N9NJ@224756|Methanomicrobia	224756|Methanomicrobia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	iAF692.Mbar_A1332	PseudoU_synth_1
HKD1_k127_2271459_2	1094980.Mpsy_1620	2.79e-182	579.0	COG0065@1|root,arCOG01698@2157|Archaea,2XTWH@28890|Euryarchaeota,2N97Z@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD1_k127_2271459_3	521011.Mpal_0662	6.295e-96	316.0	COG1350@1|root,arCOG01432@2157|Archaea,2Y845@28890|Euryarchaeota,2N98B@224756|Methanomicrobia	224756|Methanomicrobia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	-	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_22911_1	247490.KSU1_C0727	2.41e-63	224.0	COG3527@1|root,COG3527@2|Bacteria,2J1NT@203682|Planctomycetes	203682|Planctomycetes	Q	Alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
HKD1_k127_22911_0	1408433.JHXV01000009_gene1351	5.302e-84	287.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,1HYIB@117743|Flavobacteriia,2PAY6@246874|Cryomorphaceae	976|Bacteroidetes	E	Arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_22911_4	1041930.Mtc_2052	6.423e-56	204.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,2N9TJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
HKD1_k127_22911_5	429009.Adeg_0446	3.446e-16	85.0	COG1456@1|root,COG1456@2|Bacteria,1UIEM@1239|Firmicutes,25EJY@186801|Clostridia,42GZB@68295|Thermoanaerobacterales	186801|Clostridia	C	Domain of unknown function (DUF3786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3786
HKD1_k127_22911_6	70601.3258280	6.624e-13	74.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,243RJ@183968|Thermococci	183968|Thermococci	O	Belongs to the small heat shock protein (HSP20) family	hsp20	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_22911_2	748727.CLJU_c00570	1.567e-58	211.0	COG2020@1|root,COG2020@2|Bacteria,1V0PB@1239|Firmicutes,24AQ6@186801|Clostridia,36I4M@31979|Clostridiaceae	186801|Clostridia	O	Isoprenylcysteine carboxyl methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HKD1_k127_22911_3	593750.Metfor_0988	4.872e-56	205.0	COG1226@1|root,arCOG01964@2157|Archaea,2Y19J@28890|Euryarchaeota,2NADN@224756|Methanomicrobia	224756|Methanomicrobia	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
HKD1_k127_2318928_1	204669.Acid345_3442	2.434e-37	145.0	COG1388@1|root,COG1388@2|Bacteria,3Y4VG@57723|Acidobacteria,2JN09@204432|Acidobacteriia	204432|Acidobacteriia	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD1_k127_2318928_4	1123248.KB893326_gene1431	2.366e-06	53.0	2B5RU@1|root,31YMF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_2318928_2	926560.KE387025_gene4075	5.125e-08	57.0	2B5RU@1|root,31YMF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_2318928_3	589924.Ferp_0811	9.8e-07	53.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,245PZ@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	-	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD1_k127_2318928_0	269797.Mbar_A1604	7.146e-55	207.0	COG0644@1|root,arCOG00570@2157|Archaea	2157|Archaea	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1603	FAD_binding_3
HKD1_k127_2323605_2	478801.Ksed_19100	1.314e-29	123.0	COG1451@1|root,COG1451@2|Bacteria,2GMP6@201174|Actinobacteria,1ZW53@145357|Dermacoccaceae	201174|Actinobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD1_k127_2323605_3	877455.Metbo_1641	6.185e-21	97.0	COG3339@1|root,arCOG06459@2157|Archaea,2Y1VZ@28890|Euryarchaeota,23PPP@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD1_k127_2323605_4	593750.Metfor_1086	1.984e-15	80.0	COG2023@1|root,arCOG04345@2157|Archaea,2XYX0@28890|Euryarchaeota,2NA13@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp4	-	3.1.26.5	ko:K03540	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Rpr2
HKD1_k127_2323605_5	1094980.Mpsy_2195	4.931e-13	75.0	arCOG05136@1|root,arCOG05136@2157|Archaea,2Y1BS@28890|Euryarchaeota,2NA5R@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2323605_1	186497.PF0249	3.284e-47	175.0	COG0127@1|root,arCOG04184@2157|Archaea,2XTS4@28890|Euryarchaeota,243RS@183968|Thermococci	183968|Thermococci	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_2323605_0	1041930.Mtc_0524	8.506e-86	289.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2N97V@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD1_k127_2337204_2	1041930.Mtc_2376	5.247e-52	185.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_2337204_0	323259.Mhun_2549	3.484e-147	472.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_2337204_1	1254432.SCE1572_37960	9.409e-84	287.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2YWG3@29|Myxococcales	28221|Deltaproteobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
HKD1_k127_2343740_9	1304885.AUEY01000028_gene2809	9.101e-11	70.0	COG0727@1|root,COG0727@2|Bacteria,1N3F5@1224|Proteobacteria,42THI@68525|delta/epsilon subdivisions,2WRGI@28221|Deltaproteobacteria,2MKU1@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_2343740_8	1038869.AXAN01000001_gene3848	1.535e-20	94.0	COG3360@1|root,COG3360@2|Bacteria,1PW6C@1224|Proteobacteria,2VXDE@28216|Betaproteobacteria,1KB0W@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_2343740_4	1041930.Mtc_1499	1.632e-52	205.0	COG0042@1|root,arCOG00605@2157|Archaea,2XU1I@28890|Euryarchaeota,2N9FE@224756|Methanomicrobia	224756|Methanomicrobia	J	Dihydrouridine synthase (Dus)	-	-	-	-	-	-	-	-	-	-	-	-	Dus
HKD1_k127_2343740_3	192952.MM_1852	6.485e-56	205.0	COG1767@1|root,arCOG04238@2157|Archaea,2XT6S@28890|Euryarchaeota,2N9HM@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM triphosphoribosyl-dephospho-CoA protein	-	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
HKD1_k127_2343740_5	224325.AF_1834	3.503e-29	125.0	COG2457@1|root,arCOG04458@2157|Archaea,2XZFN@28890|Euryarchaeota,24704@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF447)	-	-	-	ko:K09154	-	-	-	-	ko00000	-	-	-	DUF447
HKD1_k127_2343740_2	269797.Mbar_A1039	8.456e-68	237.0	COG0468@1|root,arCOG00417@2157|Archaea,2XTI2@28890|Euryarchaeota,2N9KC@224756|Methanomicrobia	224756|Methanomicrobia	L	Involved in DNA repair and in homologous recombination. May regulate the cleavage reactions of the branch-structured DNA. Has a very weak ATPase activity that is not stimulated by DNA. Binds DNA but does not promote DNA strands exchange	radB	-	-	ko:K04484	-	-	-	-	ko00000,ko03400	-	-	-	Rad51
HKD1_k127_2343740_6	192952.MM_1293	1.837e-27	118.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2NA25@224756|Methanomicrobia	224756|Methanomicrobia	K	TIGRFAM ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_2343740_0	304371.MCP_0057	0.0	1010.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,2NAP2@224756|Methanomicrobia	224756|Methanomicrobia	D	Cell division protein 48 (CDC48) domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_2343740_1	269797.Mbar_A3023	9.691e-147	475.0	COG0626@1|root,arCOG00060@2157|Archaea,2XT98@28890|Euryarchaeota,2N9FD@224756|Methanomicrobia	224756|Methanomicrobia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.1,4.4.1.11	ko:K01758,ko:K01761	ko00260,ko00270,ko00450,ko01100,ko01130,ko01230,map00260,map00270,map00450,map01100,map01130,map01230	M00338	R00654,R00782,R01001,R02408,R04770,R04930,R09366	RC00056,RC00069,RC00196,RC00348,RC00382,RC00710,RC01209,RC01210,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD1_k127_2343740_10	391625.PPSIR1_38384	2.748e-05	51.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria,42QZQ@68525|delta/epsilon subdivisions,2WMV8@28221|Deltaproteobacteria,2YVB0@29|Myxococcales	28221|Deltaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
HKD1_k127_2343740_7	1459636.NTE_03410	1.463e-22	100.0	COG3945@1|root,arCOG01471@2157|Archaea	2157|Archaea	S	Hemerythrin HHE cation binding	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,PRC,ScdA_N
HKD1_k127_2343740_11	504472.Slin_5290	0.0003153	51.0	COG5513@1|root,COG5513@2|Bacteria,4NZ1B@976|Bacteroidetes	976|Bacteroidetes	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
HKD1_k127_236746_0	304371.MCP_0141	1.404e-67	240.0	COG1801@1|root,arCOG04291@2157|Archaea,2XY6C@28890|Euryarchaeota,2NA4H@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_236746_3	857293.CAAU_2054	2.55e-19	90.0	COG1983@1|root,COG1983@2|Bacteria,1VKBQ@1239|Firmicutes,24QU9@186801|Clostridia,36NYT@31979|Clostridiaceae	186801|Clostridia	KT	PspC domain	-	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD1_k127_236746_2	1220534.B655_1160	5.055e-30	126.0	COG4635@1|root,arCOG00524@2157|Archaea,2Y1YN@28890|Euryarchaeota	28890|Euryarchaeota	C	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD1_k127_236746_1	1198449.ACAM_0007	1.849e-30	133.0	COG0524@1|root,arCOG00014@2157|Archaea,2XPWP@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_2368078_3	269797.Mbar_A1728	6.319e-11	66.0	arCOG05126@1|root,arCOG05126@2157|Archaea,2Y4VJ@28890|Euryarchaeota,2NB3R@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2368078_4	192952.MM_1392	1.213e-05	51.0	arCOG04467@1|root,arCOG04467@2157|Archaea	2157|Archaea	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
HKD1_k127_2368078_2	1094980.Mpsy_1411	2.022e-20	97.0	COG3364@1|root,arCOG04417@2157|Archaea,2Y0WK@28890|Euryarchaeota,2N9ZI@224756|Methanomicrobia	224756|Methanomicrobia	S	Zn-ribbon containing protein	-	-	-	ko:K07163	-	-	-	-	ko00000	-	-	-	DUF2072
HKD1_k127_2368078_1	589924.Ferp_1546	8.373e-37	142.0	COG3365@1|root,arCOG04416@2157|Archaea,2XX2F@28890|Euryarchaeota,246AQ@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein conserved in archaea (DUF2073)	-	-	-	ko:K09743	-	-	-	-	ko00000	-	-	-	DUF2073
HKD1_k127_2368078_0	693661.Arcve_0233	2.036e-93	310.0	COG1100@1|root,arCOG00354@2157|Archaea,2XT36@28890|Euryarchaeota,246VT@183980|Archaeoglobi	183980|Archaeoglobi	S	GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	MMR_HSR1
HKD1_k127_2371883_0	1163398.AJJP01000197_gene4430	5.434e-07	60.0	COG0834@1|root,COG0834@2|Bacteria,1RB1S@1224|Proteobacteria,1S35U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	amino acid	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_2374193_2	760568.Desku_0877	1.567e-15	79.0	COG2411@1|root,COG2411@2|Bacteria	2|Bacteria	-	-	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	ASCH
HKD1_k127_2374193_0	1196031.ALEG01000039_gene1885	5.936e-55	202.0	COG1961@1|root,COG1961@2|Bacteria,1UTCB@1239|Firmicutes,4HBWD@91061|Bacilli,1ZD1F@1386|Bacillus	91061|Bacilli	L	Recombinase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_2374193_1	635013.TherJR_0525	7.016e-27	112.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_239063_0	386456.JQKN01000015_gene2938	7.056e-90	311.0	COG3174@1|root,arCOG04203@2157|Archaea,2XT0W@28890|Euryarchaeota	28890|Euryarchaeota	P	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HKD1_k127_239063_1	1303518.CCALI_01951	2.862e-39	151.0	COG0177@1|root,COG0177@2|Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_2407514_2	1041930.Mtc_1125	2.328e-64	225.0	COG1193@1|root,arCOG02895@2157|Archaea,2XT51@28890|Euryarchaeota,2N90Z@224756|Methanomicrobia	224756|Methanomicrobia	L	Has ATPase and non-specific DNA-binding activities	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	HHH_5,MutS_V
HKD1_k127_2407514_0	269797.Mbar_A1564	6.342e-126	414.0	COG1379@1|root,arCOG04881@2157|Archaea,2XV6K@28890|Euryarchaeota,2N99G@224756|Methanomicrobia	224756|Methanomicrobia	S	PHP C-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PHP_C
HKD1_k127_2407514_1	192952.MM_1616	9.403e-69	243.0	COG1691@1|root,arCOG02465@2157|Archaea,2XTIH@28890|Euryarchaeota,2N9MD@224756|Methanomicrobia	224756|Methanomicrobia	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD1_k127_2414772_0	323259.Mhun_1064	2.048e-19	93.0	arCOG09494@1|root,arCOG09494@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2414772_1	251229.Chro_3389	4.751e-14	74.0	2CYFR@1|root,32T44@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
HKD1_k127_2463955_6	269797.Mbar_A1062	4.851e-45	165.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbpE	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
HKD1_k127_2463955_0	224325.AF_1278	3.595e-157	506.0	COG1915@1|root,arCOG04422@2157|Archaea,2XTUK@28890|Euryarchaeota,246SH@183980|Archaeoglobi	183980|Archaeoglobi	S	LOR SDH bifunctional protein conserved domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Saccharop_dh_N
HKD1_k127_2463955_1	192952.MM_1307	1.13e-106	357.0	COG1423@1|root,arCOG04218@2157|Archaea,2XUD4@28890|Euryarchaeota,2NAK8@224756|Methanomicrobia	224756|Methanomicrobia	L	RNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
HKD1_k127_2463955_4	269797.Mbar_A0968	3.788e-70	245.0	COG0517@1|root,arCOG00600@2157|Archaea,2XYA3@28890|Euryarchaeota,2N9Q4@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_2463955_3	269797.Mbar_A0967	7.485e-78	269.0	COG0517@1|root,arCOG00600@2157|Archaea,2XXMJ@28890|Euryarchaeota,2N9JW@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
HKD1_k127_2463955_2	1094980.Mpsy_2124	1.629e-81	282.0	COG0517@1|root,arCOG00600@2157|Archaea,2XX02@28890|Euryarchaeota,2N9I1@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_2463955_5	192952.MM_1302	4.843e-64	228.0	COG0517@1|root,arCOG00602@2157|Archaea,2XYM5@28890|Euryarchaeota,2N9RH@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_2509500_0	269797.Mbar_A2668	4.87e-142	458.0	arCOG05230@1|root,arCOG05230@2157|Archaea,2Y36Z@28890|Euryarchaeota,2NAJ8@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2509500_1	304371.MCP_2383	7.105e-05	46.0	COG3408@1|root,arCOG03287@2157|Archaea,2XUJF@28890|Euryarchaeota,2N90H@224756|Methanomicrobia	224756|Methanomicrobia	G	Glycogen debranching enzyme N terminal	-	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HKD1_k127_2509500_2	886293.Sinac_4160	0.0004876	49.0	COG0071@1|root,COG0071@2|Bacteria,2J11X@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_2529596_3	269797.Mbar_A2314	4.857e-67	239.0	COG0294@1|root,arCOG01978@2157|Archaea,2Y879@28890|Euryarchaeota,2N9M1@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_2529596_2	1094980.Mpsy_1814	1.15e-77	274.0	COG1478@1|root,arCOG02714@2157|Archaea,2XXJZ@28890|Euryarchaeota,2N9JQ@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM F420-dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
HKD1_k127_2529596_5	1449126.JQKL01000073_gene3042	6.848e-30	133.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,268ZJ@186813|unclassified Clostridiales	186801|Clostridia	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD1_k127_2529596_1	1094980.Mpsy_2552	3.447e-111	375.0	COG1970@1|root,arCOG01959@2157|Archaea,2XV1N@28890|Euryarchaeota,2NBGS@224756|Methanomicrobia	224756|Methanomicrobia	P	cellular potassium ion transport	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_2529596_0	192952.MM_2500	4.041e-138	456.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_2529596_4	192952.MM_1617	3.892e-44	167.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,2N9FA@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_256714_0	555088.DealDRAFT_0489	1.101e-71	249.0	COG3387@1|root,COG3387@2|Bacteria,1TR12@1239|Firmicutes,248Q3@186801|Clostridia,42KAA@68298|Syntrophomonadaceae	186801|Clostridia	G	PFAM glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_15
HKD1_k127_256714_2	518766.Rmar_0914	9.898e-17	83.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,4NJVN@976|Bacteroidetes	976|Bacteroidetes	P	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
HKD1_k127_256714_1	269797.Mbar_A0736	3.07e-18	85.0	COG1145@1|root,arCOG01610@2157|Archaea,2Y1GK@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_2699364_0	290402.Cbei_1782	1.503e-17	83.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,36E1A@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_2707864_2	868131.MSWAN_0266	3.92e-12	75.0	COG0057@1|root,arCOG00493@2157|Archaea,2XT16@28890|Euryarchaeota,23NQF@183925|Methanobacteria	183925|Methanobacteria	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_N,Gp_dh_C
HKD1_k127_2707864_0	521011.Mpal_1433	0.0	1236.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2N97B@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_2707864_1	368407.Memar_2285	3.212e-46	171.0	arCOG00346@1|root,arCOG00346@2157|Archaea,2XU0A@28890|Euryarchaeota	28890|Euryarchaeota	S	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
HKD1_k127_2743377_2	323259.Mhun_2196	5.21e-48	175.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2NAKT@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2743377_0	521011.Mpal_1164	1.077e-125	410.0	COG2516@1|root,arCOG00662@2157|Archaea,2XV52@28890|Euryarchaeota,2N9EK@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_2743377_3	593750.Metfor_0802	2.526e-07	55.0	COG2104@1|root,arCOG00535@2157|Archaea	2157|Archaea	H	Sulfur transfer protein involved in thiamine biosynthesis	-	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_2743377_1	1094980.Mpsy_1017	2.576e-103	342.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,2NABJ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	-	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD1_k127_27646_5	439481.Aboo_0405	3.74e-57	203.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F39E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_27646_0	1041930.Mtc_1082	3.837e-223	706.0	COG0423@1|root,arCOG00405@2157|Archaea,2XSZK@28890|Euryarchaeota,2N999@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM tRNA synthetase, class II (G, H, P and S)	glyS	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD1_k127_27646_7	5762.XP_002681812.1	5.604e-10	68.0	COG0170@1|root,KOG4453@2759|Eukaryota	2759|Eukaryota	I	phytol kinase activity	DGK1	GO:0003674,GO:0003824,GO:0004143,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005783,GO:0005789,GO:0006629,GO:0006644,GO:0006650,GO:0006654,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009987,GO:0012505,GO:0016020,GO:0016021,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0030176,GO:0031224,GO:0031227,GO:0031984,GO:0042175,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045017,GO:0046473,GO:0046474,GO:0046486,GO:0071704,GO:0090407,GO:0098827,GO:1901576	2.7.1.174	ko:K16368	ko00564,ko01100,ko01110,map00564,map01100,map01110	-	R09944	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CTP_transf_1
HKD1_k127_27646_3	1041930.Mtc_1347	7.392e-84	283.0	COG0563@1|root,arCOG01046@2157|Archaea,2XTRG@28890|Euryarchaeota,2N9GB@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A0086	ADK,ADK_lid
HKD1_k127_27646_4	192952.MM_1611	3.884e-59	213.0	COG0528@1|root,arCOG00858@2157|Archaea,2XT3U@28890|Euryarchaeota,2N9K9@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0788	AA_kinase
HKD1_k127_27646_2	1094980.Mpsy_1622	1.967e-85	293.0	COG2524@1|root,arCOG00610@2157|Archaea,2XVPF@28890|Euryarchaeota,2N96A@224756|Methanomicrobia	224756|Methanomicrobia	K	signal transduction protein with CBS domains	-	-	-	ko:K07744	-	-	-	-	ko00000	-	-	-	CBS,HrcA_DNA-bdg
HKD1_k127_27646_1	1094980.Mpsy_1466	1.478e-105	353.0	COG0535@1|root,arCOG00941@2157|Archaea,2Y2UY@28890|Euryarchaeota,2NAGS@224756|Methanomicrobia	224756|Methanomicrobia	S	Iron-sulfur cluster-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM,SPASM
HKD1_k127_27646_6	192952.MM_2019	5.449e-48	175.0	COG0139@1|root,arCOG02676@2157|Archaea,2XX3X@28890|Euryarchaeota,2N9QJ@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HKD1_k127_2797639_1	323259.Mhun_1064	7.34e-16	82.0	arCOG09494@1|root,arCOG09494@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2797639_0	368407.Memar_2473	1.068e-40	158.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_2817163_4	224308.BSU05440	1.491e-33	135.0	COG0596@1|root,COG0596@2|Bacteria,1V3C8@1239|Firmicutes,4HGMA@91061|Bacilli,1ZQW7@1386|Bacillus	91061|Bacilli	S	Alpha/beta hydrolase family	-	GO:0003674,GO:0003824,GO:0016787	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_2817163_3	368407.Memar_2056	1.366e-37	151.0	COG4089@1|root,arCOG02159@2157|Archaea	2157|Archaea	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
HKD1_k127_2817163_5	42256.RradSPS_0018	5.764e-20	95.0	COG1714@1|root,COG1714@2|Bacteria,2HP4S@201174|Actinobacteria,4CQGE@84995|Rubrobacteria	84995|Rubrobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_2817163_2	521011.Mpal_0671	6.19e-57	205.0	arCOG02576@1|root,arCOG02576@2157|Archaea,2XZNM@28890|Euryarchaeota,2N9WU@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_2817163_0	402880.MmarC5_0835	6.399e-150	486.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EJ@28890|Euryarchaeota,23RD7@183939|Methanococci	183939|Methanococci	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2817163_1	868131.MSWAN_1821	8.134e-146	470.0	COG1415@1|root,arCOG04253@2157|Archaea,2XU0W@28890|Euryarchaeota,23PHY@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
HKD1_k127_2855274_0	1041930.Mtc_0281	2.254e-130	428.0	COG1571@1|root,arCOG01115@2157|Archaea,2XTGD@28890|Euryarchaeota,2N9EI@224756|Methanomicrobia	224756|Methanomicrobia	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
HKD1_k127_2855274_1	192952.MM_0444	4.563e-83	286.0	COG1395@1|root,arCOG04152@2157|Archaea,2XTMG@28890|Euryarchaeota,2N98I@224756|Methanomicrobia	224756|Methanomicrobia	K	HTH-type transcriptional regulatory protein	-	-	-	ko:K07728	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HKD1_k127_2855274_2	572546.Arcpr_1547	3.4e-17	82.0	COG0572@1|root,arCOG05133@2157|Archaea,2XU2D@28890|Euryarchaeota,245RY@183980|Archaeoglobi	183980|Archaeoglobi	G	PFAM Phosphoribulokinase uridine kinase	-	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HKD1_k127_2855274_3	1183438.GKIL_0014	2.274e-14	78.0	COG0572@1|root,COG0572@2|Bacteria,1G0G9@1117|Cyanobacteria	1117|Cyanobacteria	G	PFAM Phosphoribulokinase uridine kinase	prk	GO:0003674,GO:0003824,GO:0004849,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006213,GO:0006220,GO:0006221,GO:0006222,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008655,GO:0009058,GO:0009112,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009173,GO:0009174,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0018130,GO:0019205,GO:0019206,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0043094,GO:0043097,GO:0043174,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046049,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.prk	PRK
HKD1_k127_2855274_4	1094980.Mpsy_1489	1.775e-09	61.0	arCOG01060@1|root,arCOG01060@2157|Archaea,2Y63R@28890|Euryarchaeota,2NBB4@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2890569_1	304371.MCP_2695	3.115e-39	151.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota,2N91W@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_2890569_2	1038867.AXAY01000002_gene3808	8.15e-16	78.0	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_2890569_0	635013.TherJR_0912	6.586e-82	286.0	COG0006@1|root,COG0006@2|Bacteria,1TSXE@1239|Firmicutes,248AF@186801|Clostridia,2604W@186807|Peptococcaceae	186801|Clostridia	E	PFAM peptidase M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_2928668_1	269797.Mbar_A2808	2.264e-08	59.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,2N9YN@224756|Methanomicrobia	224756|Methanomicrobia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_2928668_2	1262449.CP6013_0761	1.346e-06	56.0	29VIW@1|root,30H17@2|Bacteria,1UGZJ@1239|Firmicutes,25PM0@186801|Clostridia,36RZ0@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2928668_0	926569.ANT_25440	4.475e-77	266.0	COG1028@1|root,COG1028@2|Bacteria,2G660@200795|Chloroflexi	200795|Chloroflexi	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_297208_0	1094980.Mpsy_2553	2.511e-107	366.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_297208_1	1122164.JHWF01000022_gene1708	1.33e-12	76.0	COG5661@1|root,COG5661@2|Bacteria,1NJW0@1224|Proteobacteria,1TBMM@1236|Gammaproteobacteria,1JG4Z@118969|Legionellales	118969|Legionellales	O	Bacterial protein of unknown function (DUF922)	-	-	-	-	-	-	-	-	-	-	-	-	DUF922
HKD1_k127_3029909_2	580327.Tthe_2432	3.132e-43	165.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,42EKW@68295|Thermoanaerobacterales	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_3029909_1	1094980.Mpsy_0116	5.991e-71	248.0	COG1721@1|root,arCOG02745@2157|Archaea,2XVGA@28890|Euryarchaeota,2NAC9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_3029909_0	1094980.Mpsy_0115	1.256e-129	421.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,2NA7N@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_3029909_3	1094980.Mpsy_0114	1.106e-19	99.0	arCOG03321@1|root,arCOG03321@2157|Archaea,2Y3WV@28890|Euryarchaeota,2NATQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3034720_2	1041930.Mtc_1961	3.79e-174	556.0	COG1973@1|root,arCOG00637@2157|Archaea,2XVGM@28890|Euryarchaeota,2N91N@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AIR synthase related protein	-	-	-	ko:K07388	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_3034720_4	1455608.JDTH01000002_gene1653	3.232e-91	321.0	COG0323@1|root,arCOG01166@2157|Archaea,2XTK1@28890|Euryarchaeota,23T13@183963|Halobacteria	183963|Halobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_3034720_1	97138.C820_00829	5.019e-236	757.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,36DR6@31979|Clostridiaceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD1_k127_3034720_5	368407.Memar_0422	2.824e-35	149.0	COG0477@1|root,arCOG00130@2157|Archaea,2XVR7@28890|Euryarchaeota	28890|Euryarchaeota	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,PUCC
HKD1_k127_3034720_8	1041930.Mtc_2273	5.662e-15	77.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,2N9YN@224756|Methanomicrobia	224756|Methanomicrobia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_3034720_7	386456.JQKN01000013_gene3073	1.476e-20	98.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_3034720_6	1094980.Mpsy_0253	1.798e-31	126.0	arCOG04911@1|root,arCOG04911@2157|Archaea,2Y1AD@28890|Euryarchaeota,2NAZV@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF3467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3467
HKD1_k127_3034720_3	269797.Mbar_A2375	5.511e-119	393.0	COG0505@1|root,arCOG00064@2157|Archaea,2XT0H@28890|Euryarchaeota,2N9D1@224756|Methanomicrobia	224756|Methanomicrobia	E	Carbamoyl-phosphate synthase, small chain	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_3034720_0	1041930.Mtc_2496	0.0	1417.0	COG0458@1|root,arCOG01594@2157|Archaea,2XTVE@28890|Euryarchaeota,2N92M@224756|Methanomicrobia	224756|Methanomicrobia	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A2374	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_3037866_15	192952.MM_1811	1.129e-08	57.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
HKD1_k127_3037866_13	1094980.Mpsy_1231	7.055e-17	88.0	COG1711@1|root,arCOG00551@2157|Archaea,2XU3R@28890|Euryarchaeota,2N9Z3@224756|Methanomicrobia	224756|Methanomicrobia	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
HKD1_k127_3037866_9	351160.LRC297	1.005e-34	134.0	COG1631@1|root,arCOG04109@2157|Archaea,2XXV3@28890|Euryarchaeota,2N9XH@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
HKD1_k127_3037866_12	589924.Ferp_1787	3.396e-18	85.0	COG2051@1|root,arCOG04108@2157|Archaea,2XZW2@28890|Euryarchaeota,247EF@183980|Archaeoglobi	183980|Archaeoglobi	J	Ribosomal protein S27E	rps27e	-	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
HKD1_k127_3037866_3	1041930.Mtc_1025	4.806e-93	312.0	COG1093@1|root,arCOG04107@2157|Archaea,2XTV0@28890|Euryarchaeota,2N93I@224756|Methanomicrobia	224756|Methanomicrobia	J	Translation initiation factor 2 alpha subunit	eif2a	-	-	ko:K03237	ko03013,ko04138,ko04140,ko04141,ko04210,ko04932,ko05160,ko05162,ko05164,ko05168,map03013,map04138,map04140,map04141,map04210,map04932,map05160,map05162,map05164,map05168	-	-	-	ko00000,ko00001,ko03012	-	-	-	EIF_2_alpha,S1
HKD1_k127_3037866_14	673860.AciM339_1478	1.151e-12	68.0	COG2260@1|root,arCOG00906@2157|Archaea,2Y1HX@28890|Euryarchaeota,3F3GI@33867|unclassified Euryarchaeota	28890|Euryarchaeota	J	more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA	nop10	-	-	ko:K11130	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko03009,ko03032	-	-	-	Nop10p
HKD1_k127_3037866_4	1041930.Mtc_1026	1.272e-92	311.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,2N9I4@224756|Methanomicrobia	224756|Methanomicrobia	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
HKD1_k127_3037866_2	192952.MM_0126	1.589e-97	334.0	COG0312@1|root,arCOG00322@2157|Archaea,2XV41@28890|Euryarchaeota,2N939@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_3037866_8	192952.MM_2205	7.381e-82	282.0	COG0462@1|root,arCOG00067@2157|Archaea,2XTA8@28890|Euryarchaeota,2N92A@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
HKD1_k127_3037866_0	269797.Mbar_A1438	4.144e-149	479.0	COG0082@1|root,arCOG04133@2157|Archaea,2XT26@28890|Euryarchaeota,2N90S@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD1_k127_3037866_1	269797.Mbar_A0575	1.971e-119	405.0	COG0303@1|root,arCOG00217@2157|Archaea,2XT2V@28890|Euryarchaeota,2N9DX@224756|Methanomicrobia	224756|Methanomicrobia	H	MoeA domain protein domain I and II	moeA-1	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HKD1_k127_3037866_6	192952.MM_1396	7.419e-87	298.0	COG2219@1|root,arCOG03013@2157|Archaea,2XTDT@28890|Euryarchaeota,2N9HY@224756|Methanomicrobia	224756|Methanomicrobia	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
HKD1_k127_3037866_7	1041930.Mtc_1270	3.862e-85	288.0	COG0592@1|root,arCOG00488@2157|Archaea,2XT8B@28890|Euryarchaeota,2N931@224756|Methanomicrobia	224756|Methanomicrobia	L	Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication	pcn	-	-	ko:K04802	ko03030,ko03410,ko03420,ko03430,ko04110,ko04530,ko05161,ko05166,map03030,map03410,map03420,map03430,map04110,map04530,map05161,map05166	M00295	-	-	ko00000,ko00001,ko00002,ko03032,ko03400	-	-	-	PCNA_C,PCNA_N
HKD1_k127_3037866_10	565033.GACE_0955	3.274e-24	105.0	COG1594@1|root,arCOG00579@2157|Archaea,2XY3E@28890|Euryarchaeota,2473M@183980|Archaeoglobi	183980|Archaeoglobi	K	Belongs to the archaeal rpoM eukaryotic RPA12 RPB9 RPC11 RNA polymerase family	-	GO:0003674,GO:0005488,GO:0006355,GO:0008150,GO:0008270,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0043167,GO:0043169,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:1903506,GO:2000112,GO:2001141	-	ko:K03057	ko01100,map01100	-	-	-	br01611,ko00000,ko03021	-	-	-	RNA_POL_M_15KD,TFIIS_C
HKD1_k127_3037866_5	1041930.Mtc_2378	5.683e-92	307.0	COG1707@1|root,arCOG00813@2157|Archaea,2XT8A@28890|Euryarchaeota,2NAE8@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	ko:K06862	-	-	-	-	ko00000	-	-	-	ACT
HKD1_k127_3037866_11	1094980.Mpsy_2209	3.056e-18	86.0	COG0695@1|root,arCOG02607@2157|Archaea,2XZVV@28890|Euryarchaeota,2N9Z7@224756|Methanomicrobia	224756|Methanomicrobia	O	COG3634 Alkyl hydroperoxide reductase, large subunit	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_3045303_4	1094980.Mpsy_0407	1.044e-109	374.0	COG0517@1|root,COG0750@1|root,arCOG00607@2157|Archaea,arCOG04064@2157|Archaea,2XSZP@28890|Euryarchaeota,2N9D0@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM peptidase M50	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M50
HKD1_k127_3045303_6	1094980.Mpsy_2545	1.994e-88	302.0	COG1548@1|root,arCOG04369@2157|Archaea,2XVPP@28890|Euryarchaeota,2N9IT@224756|Methanomicrobia	224756|Methanomicrobia	K	Hydantoinase/oxoprolinase	-	-	2.5.1.131	ko:K07072	ko00680,map00680	-	R11040	RC01372,RC03335	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_A
HKD1_k127_3045303_9	572546.Arcpr_1589	9.007e-70	250.0	COG1035@1|root,arCOG02650@2157|Archaea,2XVXF@28890|Euryarchaeota,2462X@183980|Archaeoglobi	28890|Euryarchaeota	C	PFAM Coenzyme F420 hydrogenase dehydrogenase beta subunit	-	-	1.1.98.4,1.12.98.1	ko:K00441,ko:K22174	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	R03025	RC02628	ko00000,ko00001,ko01000	-	-	-	Fer4_21,FrhB_FdhB_C,FrhB_FdhB_N
HKD1_k127_3045303_1	269797.Mbar_A1073	2.056e-150	484.0	COG0012@1|root,arCOG00357@2157|Archaea,2XTZG@28890|Euryarchaeota,2N94X@224756|Methanomicrobia	224756|Methanomicrobia	J	TGS domain protein	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
HKD1_k127_3045303_2	386456.JQKN01000008_gene1391	1.356e-125	426.0	COG0419@1|root,arCOG00368@2157|Archaea,2XTC7@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50 Mre11 complex	rad50	GO:0003674,GO:0005488,GO:0005515,GO:0042802	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_15,AAA_21,AAA_23,Rad50_zn_hook,SMC_N
HKD1_k127_3045303_3	386456.JQKN01000008_gene1390	3.804e-113	378.0	COG0420@1|root,arCOG00397@2157|Archaea,2XWH1@28890|Euryarchaeota	28890|Euryarchaeota	L	Part of the Rad50 Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single- stranded endonuclease activity	mre11	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos
HKD1_k127_3045303_0	439481.Aboo_0751	1.375e-152	497.0	COG0433@1|root,arCOG00280@2157|Archaea,2XZQZ@28890|Euryarchaeota,3F34M@33867|unclassified Euryarchaeota	28890|Euryarchaeota	L	AAA-like domain	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF87
HKD1_k127_3045303_8	386456.JQKN01000008_gene1388	1.103e-82	287.0	arCOG02665@1|root,arCOG02665@2157|Archaea,2Y893@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3045303_5	1041930.Mtc_1643	1.447e-89	310.0	COG0644@1|root,arCOG00570@2157|Archaea,2XUI9@28890|Euryarchaeota,2N9DD@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,HI0933_like,Lycopene_cycl
HKD1_k127_3045303_12	246194.CHY_1188	1.868e-31	130.0	2BWMW@1|root,32QZS@2|Bacteria,1V6ZC@1239|Firmicutes,24KAR@186801|Clostridia,42IE6@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF1638)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1638
HKD1_k127_3045303_11	1094980.Mpsy_1303	1.807e-40	153.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_3045303_10	192952.MM_0092	1.826e-43	172.0	arCOG03477@1|root,arCOG03477@2157|Archaea,2Y33T@28890|Euryarchaeota,2NANU@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3045303_7	1094980.Mpsy_1277	4.277e-88	297.0	COG1136@1|root,arCOG00922@2157|Archaea,2Y33K@28890|Euryarchaeota,2NAC3@224756|Methanomicrobia	224756|Methanomicrobia	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD1_k127_3045303_13	351160.RCIX123	5.642e-14	75.0	COG0616@1|root,arCOG01911@2157|Archaea,2XU7H@28890|Euryarchaeota,2N9SV@224756|Methanomicrobia	224756|Methanomicrobia	O	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
HKD1_k127_3074616_3	351160.RCIX2161	9.539e-29	119.0	COG1833@1|root,arCOG00463@2157|Archaea,2Y00K@28890|Euryarchaeota,2NB15@224756|Methanomicrobia	224756|Methanomicrobia	L	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
HKD1_k127_3074616_4	208444.JNYY01000002_gene1676	2.397e-11	78.0	COG1361@1|root,COG1361@2|Bacteria,2I8F1@201174|Actinobacteria,4DZF8@85010|Pseudonocardiales	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD1_k127_3074616_1	1094980.Mpsy_2854	1.417e-57	205.0	COG0311@1|root,arCOG00034@2157|Archaea,2XTZS@28890|Euryarchaeota,2N9HT@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HKD1_k127_3074616_0	269797.Mbar_A3581	7.538e-136	437.0	COG0214@1|root,arCOG04075@2157|Archaea,2XSYK@28890|Euryarchaeota,2N9DB@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively	pdxS	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HKD1_k127_3074616_2	269797.Mbar_A2751	3.256e-40	165.0	arCOG02527@1|root,arCOG02527@2157|Archaea,2Y6XK@28890|Euryarchaeota,2NAMP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3075047_1	593750.Metfor_2560	3.972e-106	351.0	COG0648@1|root,arCOG01894@2157|Archaea,2XV5I@28890|Euryarchaeota	28890|Euryarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_3075047_3	388399.SSE37_02910	5.641e-07	61.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2TUPX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD1_k127_3075047_0	192952.MM_3284	1.731e-195	615.0	COG0641@1|root,arCOG00945@2157|Archaea,2XV96@28890|Euryarchaeota,2NABU@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Radical SAM domain protein	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_3075047_2	456442.Mboo_0560	1.063e-76	261.0	COG4866@1|root,arCOG05191@2157|Archaea,2Y2YS@28890|Euryarchaeota,2NADR@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
HKD1_k127_3082683_1	866775.HMPREF9243_0477	8.465e-11	70.0	COG4502@1|root,COG4502@2|Bacteria,1V87A@1239|Firmicutes,4HJ5I@91061|Bacilli	91061|Bacilli	S	5'(3')-deoxyribonucleotidase	-	-	-	-	-	-	-	-	-	-	-	-	NT5C
HKD1_k127_3082683_0	1469607.KK073768_gene4780	2.584e-87	300.0	COG3264@1|root,COG3264@2|Bacteria,1GQ30@1117|Cyanobacteria,1HKUV@1161|Nostocales	1117|Cyanobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_3082683_2	7955.ENSDARP00000111544	0.0004512	44.0	COG3321@1|root,KOG1202@2759|Eukaryota,38D6P@33154|Opisthokonta,3BJ45@33208|Metazoa,3D3Z3@33213|Bilateria,484AG@7711|Chordata,497MS@7742|Vertebrata,49YJ6@7898|Actinopterygii	33208|Metazoa	I	polyketide synthase	FASN	GO:0003674,GO:0003824,GO:0004312,GO:0005975,GO:0005976,GO:0005977,GO:0006073,GO:0006082,GO:0006091,GO:0006112,GO:0006629,GO:0006631,GO:0006633,GO:0006638,GO:0006639,GO:0006641,GO:0006723,GO:0007275,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009743,GO:0009744,GO:0009987,GO:0010033,GO:0015980,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0019432,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0034285,GO:0042221,GO:0042335,GO:0043170,GO:0043436,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044281,GO:0044283,GO:0045017,GO:0046394,GO:0046460,GO:0046463,GO:0046486,GO:0048856,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0071310,GO:0071322,GO:0071324,GO:0071329,GO:0071704,GO:0072330,GO:0097089,GO:1901576,GO:1901700,GO:1901701,GO:1902321	2.3.1.85	ko:K00665	ko00061,ko01100,ko01212,ko04152,ko04910,map00061,map01100,map01212,map04152,map04910	M00082,M00083	R01404,R01624,R01626,R01706,R04355,R04428,R04430,R04533,R04534,R04535,R04536,R04537,R04543,R04544,R04566,R04568,R04725,R04726,R04952,R04953,R04954,R04956,R04957,R04959,R04960,R04962,R04963,R04965,R04967,R04968,R04970,R08159	RC00004,RC00014,RC00029,RC00039,RC00052,RC00076,RC00117,RC00120,RC00831,RC01095,RC02727,RC02728,RC02729,RC02857,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	-	-	-	ADH_zinc_N,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
HKD1_k127_3108717_2	273116.14325675	4.992e-08	58.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3108717_1	1094980.Mpsy_0033	3.381e-11	66.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3108717_0	297246.lpp1650	7.675e-204	659.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,1JDPB@118969|Legionellales	118969|Legionellales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_3108717_3	1122165.AUHS01000015_gene701	0.0008483	42.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,1SVID@1236|Gammaproteobacteria,1JD85@118969|Legionellales	118969|Legionellales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_3115504_8	1094980.Mpsy_1468	4.926e-14	74.0	COG0382@1|root,arCOG00482@2157|Archaea,2Y6XF@28890|Euryarchaeota,2NAKF@224756|Methanomicrobia	224756|Methanomicrobia	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_3115504_5	1280390.CBQR020000041_gene905	8.669e-31	126.0	COG3428@1|root,COG3428@2|Bacteria,1V9YB@1239|Firmicutes,4HS5J@91061|Bacilli,26X6Y@186822|Paenibacillaceae	91061|Bacilli	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2,zinc_ribbon_2
HKD1_k127_3115504_0	521011.Mpal_2113	1.302e-177	581.0	COG0834@1|root,COG1301@1|root,arCOG01799@2157|Archaea,arCOG04335@2157|Archaea	2157|Archaea	C	COG1301 Na H -dicarboxylate symporters	gltP	GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039	-	ko:K02030,ko:K07862	-	M00236	-	-	ko00000,ko00002,ko02000	2.A.23.4,3.A.1.3	-	-	SBP_bac_3,SDF
HKD1_k127_3115504_3	521011.Mpal_1231	1.769e-41	157.0	COG4978@1|root,arCOG03200@2157|Archaea,2XYDM@28890|Euryarchaeota,2NBJ9@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription activator, effector binding	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD1_k127_3115504_7	243232.MJ_1516	2.394e-19	91.0	COG2314@1|root,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,TM2
HKD1_k127_3115504_4	269797.Mbar_A3054	6.927e-41	157.0	COG1618@1|root,arCOG01034@2157|Archaea,2XX6U@28890|Euryarchaeota	28890|Euryarchaeota	F	Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency	-	-	3.6.1.15	ko:K06928	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00086,R00615	RC00002	ko00000,ko00001,ko01000	-	-	-	NTPase_1
HKD1_k127_3115504_1	335543.Sfum_0920	1.488e-51	186.0	COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	KQ	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_3115504_6	351627.Csac_1850	9.179e-21	96.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,42EUR@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM UvrD REP helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_3115504_2	411464.DESPIG_01164	1.096e-49	201.0	COG0210@1|root,COG2887@1|root,COG0210@2|Bacteria,COG2887@2|Bacteria,1MU0G@1224|Proteobacteria,42MKU@68525|delta/epsilon subdivisions,2WJR3@28221|Deltaproteobacteria,2M9BW@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_3117720_2	593750.Metfor_2627	3.131e-43	161.0	COG4866@1|root,arCOG05191@2157|Archaea	2157|Archaea	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
HKD1_k127_3117720_3	1249997.JHZW01000003_gene3298	1.341e-13	79.0	COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1HXK5@117743|Flavobacteriia,2PHVY@252356|Maribacter	976|Bacteroidetes	P	Domain present in carbohydrate binding proteins and sugar hydrolses	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD1_k127_3117720_1	1094980.Mpsy_1575	7.083e-50	187.0	COG4087@1|root,arCOG01579@2157|Archaea,2XXV0@28890|Euryarchaeota,2N9NS@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Haloacid dehalogenase domain protein hydrolase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	iAF692.Mbar_A0708	Hydrolase
HKD1_k127_3117720_0	272134.KB731324_gene5884	8.198e-54	204.0	COG0778@1|root,COG0778@2|Bacteria,1G5XK@1117|Cyanobacteria,1HE79@1150|Oscillatoriales	1117|Cyanobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_3117720_4	744980.TRICHSKD4_2948	2.811e-07	61.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Membrane	omp28	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD1_k127_3129691_2	304371.MCP_2514	4.759e-85	286.0	COG0616@1|root,arCOG01911@2157|Archaea,2XU7H@28890|Euryarchaeota,2N9SV@224756|Methanomicrobia	224756|Methanomicrobia	O	Serine dehydrogenase proteinase	-	-	-	-	-	-	-	-	-	-	-	-	SDH_sah
HKD1_k127_3129691_3	269797.Mbar_A1392	5.039e-82	284.0	COG2520@1|root,arCOG00033@2157|Archaea,2XTSI@28890|Euryarchaeota,2N925@224756|Methanomicrobia	224756|Methanomicrobia	J	Methyltransferase	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
HKD1_k127_3129691_0	269797.Mbar_A3256	7.507e-133	434.0	COG0452@1|root,arCOG01704@2157|Archaea,2XTZK@28890|Euryarchaeota,2N9EA@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	dfp	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_3129691_4	304371.MCP_2676	2.551e-66	235.0	COG1829@1|root,arCOG04263@2157|Archaea,2XST6@28890|Euryarchaeota,2N9J3@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM GHMP kinase	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A3255	GHMP_kinases_N
HKD1_k127_3129691_1	1041930.Mtc_0974	2.417e-91	307.0	COG1701@1|root,arCOG04262@2157|Archaea,2XTAP@28890|Euryarchaeota,2N9DE@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
HKD1_k127_3129691_5	316274.Haur_3484	5.943e-11	69.0	COG5330@1|root,COG5330@2|Bacteria	2|Bacteria	K	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336,LRV
HKD1_k127_3133736_3	56780.SYN_00469	3.518e-52	188.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2MQDS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_3133736_2	192952.MM_2862	7.774e-55	203.0	COG4022@1|root,arCOG04893@2157|Archaea,2XVN1@28890|Euryarchaeota,2N9I3@224756|Methanomicrobia	224756|Methanomicrobia	S	Methanogenesis marker protein 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF2099
HKD1_k127_3133736_4	373903.Hore_11290	4.188e-45	169.0	COG0693@1|root,COG0693@2|Bacteria,1V3WB@1239|Firmicutes,24HGU@186801|Clostridia,3WAPY@53433|Halanaerobiales	186801|Clostridia	S	TIGRFAM DJ-1 family protein	-	-	3.5.1.124	ko:K03152	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_3133736_5	1094980.Mpsy_0033	1.617e-23	104.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3133736_6	1094980.Mpsy_1834	1.967e-19	92.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3133736_7	1094980.Mpsy_1243	1.001e-16	82.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3133736_1	593750.Metfor_0088	8.566e-103	346.0	COG3199@1|root,arCOG01350@2157|Archaea,2XUIQ@28890|Euryarchaeota	28890|Euryarchaeota	S	ATP-NAD AcoX kinase	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD1_k127_3133736_0	351627.Csac_0030	3.054e-130	421.0	COG1350@1|root,COG1350@2|Bacteria,1UI01@1239|Firmicutes,25E8Q@186801|Clostridia,42ETT@68295|Thermoanaerobacterales	186801|Clostridia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K06001	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3137596_3	323259.Mhun_1270	0.0005102	43.0	COG2015@1|root,arCOG00508@2157|Archaea	2157|Archaea	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
HKD1_k127_3137596_1	323259.Mhun_1270	1.69e-13	74.0	COG2015@1|root,arCOG00508@2157|Archaea	2157|Archaea	Q	Alkyl sulfatase dimerisation	-	-	-	-	-	-	-	-	-	-	-	-	Alkyl_sulf_C,Alkyl_sulf_dimr,Lactamase_B
HKD1_k127_3137596_0	269797.Mbar_A3546	4.779e-147	478.0	COG1900@1|root,arCOG00621@2157|Archaea,2XTFR@28890|Euryarchaeota,2N98V@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,HcyBio
HKD1_k127_3137596_2	425104.Ssed_3294	2.875e-07	54.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD1_k127_3140250_0	304371.MCP_0398	3.285e-294	920.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,2NAKX@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_3140250_1	269797.Mbar_A0977	4.107e-127	416.0	COG0076@1|root,arCOG00027@2157|Archaea,2XT09@28890|Euryarchaeota,2N9FF@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of L-tyrosine to produce tyramine for methanofuran biosynthesis. Can also catalyze the decarboxylation of L-aspartate to produce beta-alanine for coenzyme A (CoA) biosynthesis	mfnA	-	4.1.1.11,4.1.1.25	ko:K18933	ko00350,ko00410,ko00680,ko00770,ko01100,ko01110,map00350,map00410,map00680,map00770,map01100,map01110	-	R00489,R00736	RC00299	ko00000,ko00001,ko01000	-	-	-	Pyridoxal_deC
HKD1_k127_3140250_4	877455.Metbo_0344	3.616e-22	97.0	COG3269@1|root,arCOG01641@2157|Archaea,2Y1N9@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Deoxyribonuclease rho motif-related TRAM	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
HKD1_k127_3140250_3	589924.Ferp_0003	1.807e-102	345.0	COG1060@1|root,arCOG00656@2157|Archaea,2XU6S@28890|Euryarchaeota,245QQ@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofH	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_3140250_2	1041930.Mtc_0469	1.476e-105	347.0	COG1933@1|root,arCOG04447@2157|Archaea,2XU5S@28890|Euryarchaeota,2N91E@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
HKD1_k127_3171450_1	342949.PNA2_0441	7.426e-14	77.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,243RJ@183968|Thermococci	183968|Thermococci	O	Belongs to the small heat shock protein (HSP20) family	hsp20	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_3171450_0	1094980.Mpsy_1669	9.652e-151	490.0	COG0018@1|root,arCOG00487@2157|Archaea,2XTWP@28890|Euryarchaeota,2N9C5@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_3181923_0	1504319.GM45_0480	1.621e-48	193.0	COG0477@1|root,COG2814@2|Bacteria,2H4H5@201174|Actinobacteria	201174|Actinobacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_3206439_1	56780.SYN_02122	8.974e-102	337.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,42MXQ@68525|delta/epsilon subdivisions,2WK2D@28221|Deltaproteobacteria,2MQXB@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Threonine synthase N terminus	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD1_k127_3206439_2	1094980.Mpsy_1780	1.604e-92	313.0	COG0620@1|root,arCOG01878@2157|Archaea,2XWEP@28890|Euryarchaeota,2NA99@224756|Methanomicrobia	224756|Methanomicrobia	E	5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity	-	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1023	-
HKD1_k127_3206439_4	1094980.Mpsy_2706	7.654e-42	158.0	arCOG03354@1|root,arCOG03355@2157|Archaea,2Y3M0@28890|Euryarchaeota,2NAVA@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1699)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1699
HKD1_k127_3206439_3	1094980.Mpsy_1424	1.027e-79	271.0	COG0149@1|root,arCOG01087@2157|Archaea,2XTY3@28890|Euryarchaeota,2N9G7@224756|Methanomicrobia	224756|Methanomicrobia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM,ThiG
HKD1_k127_3206439_6	102232.GLO73106DRAFT_00028100	3.523e-18	87.0	COG1254@1|root,COG1254@2|Bacteria,1G7UW@1117|Cyanobacteria	1117|Cyanobacteria	C	Belongs to the acylphosphatase family	acyP	GO:0003674,GO:0003824,GO:0003998,GO:0016787,GO:0016817,GO:0016818	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD1_k127_3206439_5	1094980.Mpsy_2555	5.75e-20	90.0	COG1145@1|root,arCOG00958@2157|Archaea,2Y1CC@28890|Euryarchaeota,2NA30@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_3206439_0	1094980.Mpsy_2554	6.879e-135	439.0	COG0644@1|root,arCOG00570@2157|Archaea,2XU3J@28890|Euryarchaeota,2N99C@224756|Methanomicrobia	224756|Methanomicrobia	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	bchP	-	1.3.1.101,1.3.7.11	ko:K17830	ko00564,map00564	-	R10325,R10326,R10331	RC03134	ko00000,ko00001,ko01000	-	-	-	FAD_binding_2,FAD_binding_3
HKD1_k127_3252612_2	177437.HRM2_00160	0.0005078	53.0	COG5513@1|root,COG5513@2|Bacteria	2|Bacteria	G	serine-type aminopeptidase activity	-	-	-	ko:K02030,ko:K14475	ko05143,map05143	M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	Inhibitor_I42
HKD1_k127_3252612_1	1348583.ATLH01000005_gene882	2.831e-40	171.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hemopexin,Laminin_G_3,Metalloenzyme,Metallophos,PA-IIL,PA14,PglZ,Phosphodiest
HKD1_k127_3252612_0	1128421.JAGA01000002_gene1985	2.009e-81	297.0	COG0823@1|root,COG4995@1|root,COG0823@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CHAT,PD40,WD40
HKD1_k127_3298369_9	192952.MM_1827	9.41e-13	68.0	COG5016@1|root,arCOG02095@2157|Archaea,2XV3W@28890|Euryarchaeota,2N90X@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM oxaloacetate decarboxylase alpha subunit	pycB	-	6.4.1.1	ko:K01960	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1586	Biotin_lipoyl,HMGL-like,PYC_OADA
HKD1_k127_3298369_6	192952.MM_0336	6.317e-38	146.0	arCOG03354@1|root,arCOG03355@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1699)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1699
HKD1_k127_3298369_3	1094980.Mpsy_1467	1.39e-90	311.0	COG0644@1|root,arCOG00570@2157|Archaea,2Y2P2@28890|Euryarchaeota,2NAFJ@224756|Methanomicrobia	224756|Methanomicrobia	C	Lycopene cyclase protein	-	-	-	-	-	-	-	-	-	-	-	-	HI0933_like
HKD1_k127_3298369_2	192952.MM_2362	3.978e-92	311.0	COG1685@1|root,arCOG01025@2157|Archaea,2XUI2@28890|Euryarchaeota,2N96J@224756|Methanomicrobia	224756|Methanomicrobia	E	shikimate kinase activity	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3127	GHMP_kinases_N
HKD1_k127_3298369_8	351160.RCIX1315	1.587e-17	86.0	COG1605@1|root,arCOG02098@2157|Archaea,2Y6AQ@28890|Euryarchaeota,2N9YR@224756|Methanomicrobia	224756|Methanomicrobia	E	chorismate mutase	aroQ	-	5.4.99.5	ko:K04093	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R01715	RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2
HKD1_k127_3298369_5	1041930.Mtc_0528	1.398e-44	168.0	COG0041@1|root,arCOG02464@2157|Archaea,2XU0P@28890|Euryarchaeota,2N9SG@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_3298369_7	365044.Pnap_0788	2.544e-20	96.0	COG0589@1|root,COG0589@2|Bacteria,1MZ3K@1224|Proteobacteria,2VQAE@28216|Betaproteobacteria,4AE1K@80864|Comamonadaceae	28216|Betaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3298369_1	387631.Asulf_00166	6.427e-134	435.0	COG1363@1|root,arCOG01518@2157|Archaea,2XT3M@28890|Euryarchaeota,245NR@183980|Archaeoglobi	183980|Archaeoglobi	G	PFAM peptidase M42	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD1_k127_3298369_0	368407.Memar_0701	2.11e-165	535.0	COG1907@1|root,arCOG01026@2157|Archaea,2XUFK@28890|Euryarchaeota,2N92U@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P)	-	-	2.4.2.54	ko:K06984	ko00790,map00790	-	R10337,R11102	-	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A0806	DUF98,GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_3298369_4	224325.AF_1736	3.442e-45	167.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota,245ZK@183980|Archaeoglobi	183980|Archaeoglobi	I	Hydroxymethylglutaryl-CoA reductase, degradative	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
HKD1_k127_3300492_0	118168.MC7420_1809	4.506e-69	239.0	COG0053@1|root,COG0053@2|Bacteria	2|Bacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	2.5.1.105	ko:K04088,ko:K06897	ko00790,map00790	M00742	R10339	RC00121	ko00000,ko00001,ko00002,ko01000	-	-	-	Cation_efflux
HKD1_k127_3303944_2	1366050.N234_08835	2.982e-09	68.0	2C1PD@1|root,326ZJ@2|Bacteria,1RHSG@1224|Proteobacteria,2W3NH@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3303944_0	1094980.Mpsy_1815	1.522e-136	446.0	COG0422@1|root,arCOG02741@2157|Archaea,2Y2NF@28890|Euryarchaeota,2NAHH@224756|Methanomicrobia	224756|Methanomicrobia	H	Radical SAM ThiC family	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
HKD1_k127_3303944_1	981369.JQMJ01000003_gene7132	3.783e-46	177.0	COG4106@1|root,COG4106@2|Bacteria,2I3BA@201174|Actinobacteria,2NNJ5@228398|Streptacidiphilus	201174|Actinobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_3304093_11	192952.MM_0232	7.587e-31	125.0	COG3324@1|root,arCOG04946@2157|Archaea,2Y3YR@28890|Euryarchaeota,2NB03@224756|Methanomicrobia	224756|Methanomicrobia	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_3304093_13	1094980.Mpsy_3046	2.124e-17	85.0	arCOG03390@1|root,arCOG03390@2157|Archaea,2Y08K@28890|Euryarchaeota,2N9YI@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3304093_0	65393.PCC7424_5240	6.29e-266	831.0	COG0366@1|root,COG0366@2|Bacteria,1G0NX@1117|Cyanobacteria,3KJ4B@43988|Cyanothece	1117|Cyanobacteria	G	PFAM alpha amylase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase,CBM_20
HKD1_k127_3304093_5	521011.Mpal_1075	1.078e-78	270.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_3304093_2	456442.Mboo_0736	9.31e-100	331.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_3304093_7	521011.Mpal_1077	5.051e-74	264.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV0M@28890|Euryarchaeota	28890|Euryarchaeota	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD1_k127_3304093_6	526227.Mesil_3294	1.416e-76	272.0	COG0683@1|root,COG0683@2|Bacteria,1WKAP@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_3304093_8	565033.GACE_0199	5.5e-68	237.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,246UA@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
HKD1_k127_3304093_15	565033.GACE_0199	0.0001746	44.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,246UA@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
HKD1_k127_3304093_9	693661.Arcve_2005	9.522e-43	158.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota,2475X@183980|Archaeoglobi	28890|Euryarchaeota	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_3304093_12	351160.RRC432	1.968e-17	84.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota,2N971@224756|Methanomicrobia	224756|Methanomicrobia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_3304093_1	351160.RRC432	3.081e-148	475.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota,2N971@224756|Methanomicrobia	224756|Methanomicrobia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_3304093_10	1455608.JDTH01000002_gene1235	2.956e-35	146.0	COG0003@1|root,arCOG02849@2157|Archaea,2XT6V@28890|Euryarchaeota,23TEX@183963|Halobacteria	183963|Halobacteria	D	Arsenite-activated ATPase ArsA	arsA1	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD1_k127_3304093_3	926569.ANT_15200	3.783e-93	317.0	COG0387@1|root,COG0387@2|Bacteria,2G6GE@200795|Chloroflexi	200795|Chloroflexi	P	PFAM sodium calcium exchanger membrane region	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HKD1_k127_3304093_4	1094980.Mpsy_1648	1.187e-80	277.0	COG0778@1|root,arCOG00288@2157|Archaea,2XXW2@28890|Euryarchaeota,2N9TG@224756|Methanomicrobia	224756|Methanomicrobia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_3304093_14	868131.MSWAN_1100	1.286e-07	56.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota	28890|Euryarchaeota	O	TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_335703_1	1304872.JAGC01000009_gene813	1.146e-81	283.0	COG1227@1|root,COG1227@2|Bacteria,1P9JN@1224|Proteobacteria,42N0W@68525|delta/epsilon subdivisions,2WK0Q@28221|Deltaproteobacteria,2M998@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	phosphoesterase RecJ domain protein	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD1_k127_335703_3	192952.MM_1111	6.869e-42	162.0	COG0125@1|root,arCOG01891@2157|Archaea,2XTAM@28890|Euryarchaeota,2N9Y8@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_335703_2	1094980.Mpsy_0258	2.803e-71	247.0	COG1634@1|root,arCOG04303@2157|Archaea,2XT8R@28890|Euryarchaeota,2N9JZ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
HKD1_k127_335703_0	1041930.Mtc_0681	4.13e-90	307.0	COG1340@1|root,arCOG01159@2157|Archaea,2XU21@28890|Euryarchaeota,2N93Q@224756|Methanomicrobia	224756|Methanomicrobia	S	archaeal coiled-coil protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_335703_4	1123228.AUIH01000043_gene1788	4.017e-17	85.0	COG3874@1|root,COG3874@2|Bacteria,1N4RT@1224|Proteobacteria,1SQI8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HKD1_k127_3365586_0	1094980.Mpsy_1387	1.297e-124	404.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,2N92B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
HKD1_k127_3365586_1	1236689.MMALV_12580	9.671e-121	396.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,3F2I6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	C-terminal region of MMR_HSR1 domain	drg	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
HKD1_k127_3382724_1	187272.Mlg_1220	1.867e-08	63.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,1T1K1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	CBS domain	hrp1	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_3382724_0	717785.HYPMC_1714	2.511e-70	249.0	COG2510@1|root,COG2510@2|Bacteria,1NKIJ@1224|Proteobacteria,2UN1N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3385151_1	1094980.Mpsy_1961	4.329e-14	74.0	COG0262@1|root,arCOG01490@2157|Archaea,2XYCD@28890|Euryarchaeota	28890|Euryarchaeota	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_3385151_0	1125863.JAFN01000001_gene1617	6.525e-203	647.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,42MEM@68525|delta/epsilon subdivisions,2WK23@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD1_k127_3404750_0	1094980.Mpsy_1468	4.307e-85	289.0	COG0382@1|root,arCOG00482@2157|Archaea,2Y6XF@28890|Euryarchaeota,2NAKF@224756|Methanomicrobia	224756|Methanomicrobia	H	UbiA prenyltransferase family	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_3404750_1	1041930.Mtc_0169	6.206e-80	273.0	COG2140@1|root,arCOG02602@2157|Archaea,2XWS8@28890|Euryarchaeota,2N9IM@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Glucose-6-phosphate isomerase	gpi	-	5.3.1.9	ko:K06859	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	GPI
HKD1_k127_3404750_2	868131.MSWAN_1782	1.25e-11	68.0	COG2454@1|root,arCOG03229@2157|Archaea,2XZNK@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
HKD1_k127_342611_2	1094980.Mpsy_0232	4.533e-10	64.0	arCOG05126@1|root,arCOG05126@2157|Archaea,2Y4VJ@28890|Euryarchaeota,2NB3R@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_342611_0	797209.ZOD2009_09460	2.773e-19	102.0	COG2897@1|root,arCOG02019@2157|Archaea,2XV9X@28890|Euryarchaeota,23UYX@183963|Halobacteria	183963|Halobacteria	P	COG2897 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_342611_1	273063.STK_17840	1.196e-17	94.0	COG2897@1|root,arCOG02019@2157|Archaea,2XQ1X@28889|Crenarchaeota	28889|Crenarchaeota	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_3434283_1	192952.MM_2812	2.541e-150	486.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
HKD1_k127_3434283_0	1094980.Mpsy_2085	1.137e-161	523.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,2N94C@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
HKD1_k127_3434283_2	1123371.ATXH01000012_gene1459	2.386e-56	204.0	COG1402@1|root,COG1402@2|Bacteria,2GH3V@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_3444346_0	521011.Mpal_2113	2.643e-51	190.0	COG0834@1|root,COG1301@1|root,arCOG01799@2157|Archaea,arCOG04335@2157|Archaea	2157|Archaea	C	COG1301 Na H -dicarboxylate symporters	gltP	GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039	-	ko:K02030,ko:K07862	-	M00236	-	-	ko00000,ko00002,ko02000	2.A.23.4,3.A.1.3	-	-	SBP_bac_3,SDF
HKD1_k127_3465689_0	192952.MM_1362	6.175e-96	324.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV39@28890|Euryarchaeota,2N923@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC transporter, substrate-binding protein, aliphatic	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD1_k127_3465689_2	1220534.B655_1281	5.388e-21	96.0	COG1366@1|root,arCOG06891@2157|Archaea,2Y4H8@28890|Euryarchaeota	28890|Euryarchaeota	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD1_k127_3465689_1	1410624.JNKK01000027_gene2721	1.161e-28	124.0	COG2172@1|root,COG2208@1|root,COG2172@2|Bacteria,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,27JID@186928|unclassified Lachnospiraceae	186801|Clostridia	KT	Sigma factor PP2C-like phosphatases	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
HKD1_k127_3482798_1	35703.DQ02_02835	2.812e-26	111.0	COG0549@1|root,COG0549@2|Bacteria,1MWXC@1224|Proteobacteria,1RP78@1236|Gammaproteobacteria,3WX12@544|Citrobacter	1236|Gammaproteobacteria	E	Amino acid kinase family	arcC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006525,GO:0006527,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008804,GO:0009056,GO:0009063,GO:0009064,GO:0009065,GO:0009987,GO:0016054,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0019546,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	iJN746.PP_0999	AA_kinase
HKD1_k127_3482798_0	523850.TON_1432	1.545e-174	558.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD1_k127_3534702_0	192952.MM_2869	6.375e-51	187.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y2AR@28890|Euryarchaeota,2NA7W@224756|Methanomicrobia	224756|Methanomicrobia	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
HKD1_k127_3534702_3	469596.HMPREF9488_02785	1.436e-06	53.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,3VQ7F@526524|Erysipelotrichia	526524|Erysipelotrichia	C	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_3534702_1	368407.Memar_2454	2.472e-35	138.0	COG4802@1|root,arCOG01100@2157|Archaea,2XXWK@28890|Euryarchaeota	28890|Euryarchaeota	C	Ferredoxin thioredoxin reductase catalytic beta chain	-	-	-	-	-	-	-	-	-	-	-	-	FeThRed_B
HKD1_k127_3534702_2	304371.MCP_2398	1.909e-31	124.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota,2NB72@224756|Methanomicrobia	224756|Methanomicrobia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_353768_2	192952.MM_0232	3.068e-10	64.0	COG3324@1|root,arCOG04946@2157|Archaea,2Y3YR@28890|Euryarchaeota,2NB03@224756|Methanomicrobia	224756|Methanomicrobia	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_353768_0	192952.MM_0232	3.553e-16	81.0	COG3324@1|root,arCOG04946@2157|Archaea,2Y3YR@28890|Euryarchaeota,2NB03@224756|Methanomicrobia	224756|Methanomicrobia	S	Glyoxalase-like domain	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_353768_1	1463861.JNXE01000007_gene909	1.891e-10	63.0	COG0640@1|root,COG3832@1|root,COG0640@2|Bacteria,COG3832@2|Bacteria,2GNW2@201174|Actinobacteria	201174|Actinobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,HTH_20
HKD1_k127_353768_3	402880.MmarC5_0242	3.122e-06	55.0	arCOG07632@1|root,arCOG07632@2157|Archaea	2157|Archaea	V	PFAM Telomeric repeat-binding factor 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF4352
HKD1_k127_3541292_1	338966.Ppro_0407	1.562e-72	249.0	COG0366@1|root,COG0366@2|Bacteria,1PDXT@1224|Proteobacteria	1224|Proteobacteria	G	alpha amylase, catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD1_k127_3541292_0	706587.Desti_1687	1.171e-173	558.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD1_k127_354949_0	521011.Mpal_1185	2.493e-208	666.0	COG0417@1|root,arCOG00329@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
HKD1_k127_354949_1	521011.Mpal_1186	8.987e-10	62.0	arCOG07300@1|root,arCOG07300@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3563450_3	304371.MCP_0625	4.663e-124	407.0	COG1812@1|root,arCOG01678@2157|Archaea,2XT7J@28890|Euryarchaeota,2N9CD@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the formation of S-adenosylmethionine from methionine and ATP	mat	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_Synthase
HKD1_k127_3563450_7	304371.MCP_1466	6.14e-26	109.0	COG4004@1|root,arCOG04412@2157|Archaea,2Y12M@28890|Euryarchaeota,2N9YP@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3563450_0	1094980.Mpsy_1274	5.513e-170	543.0	COG0148@1|root,arCOG01169@2157|Archaea,2XSXT@28890|Euryarchaeota,2N970@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	iAF692.Mbar_A2850	Enolase_C,Enolase_N
HKD1_k127_3563450_4	521011.Mpal_1825	7.197e-64	224.0	COG4739@1|root,arCOG04483@2157|Archaea,2XYZT@28890|Euryarchaeota,2N9WC@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein containing a ferredoxin domain (DUF2148)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2148,FeS
HKD1_k127_3563450_1	1094980.Mpsy_2918	5.136e-143	463.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9D7@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3563450_5	589924.Ferp_2447	1.324e-58	206.0	COG0054@1|root,arCOG01323@2157|Archaea,2XXXC@28890|Euryarchaeota,24651@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_3563450_2	368407.Memar_1735	2.335e-130	421.0	COG0115@1|root,arCOG02297@2157|Archaea,2XT9V@28890|Euryarchaeota,2N9CI@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_3563450_6	693661.Arcve_0228	8.016e-39	148.0	COG0432@1|root,arCOG04214@2157|Archaea,2XXSW@28890|Euryarchaeota,246A9@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_3567087_0	1278073.MYSTI_00905	1.14e-129	430.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,43BX1@68525|delta/epsilon subdivisions,2X77U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Phytoene dehydrogenase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD1_k127_3567087_3	42256.RradSPS_0731	9.259e-50	190.0	COG1562@1|root,COG1562@2|Bacteria,2GJN2@201174|Actinobacteria,4CQ0Z@84995|Rubrobacteria	84995|Rubrobacteria	I	Squalene/phytoene synthase	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD1_k127_3567087_4	649638.Trad_2243	3.819e-41	163.0	COG0204@1|root,COG2324@1|root,COG0204@2|Bacteria,COG2324@2|Bacteria,1WI4U@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	TIGRFAM lycopene cyclase domain	-	-	5.5.1.19	ko:K22502	ko00906,map00906	-	R03824,R05341	RC01004	ko00000,ko00001,ko01000	-	-	-	Caroten_synth
HKD1_k127_3567087_7	32057.KB217478_gene681	4.778e-10	65.0	COG0778@1|root,COG0778@2|Bacteria,1G5XK@1117|Cyanobacteria,1HRZS@1161|Nostocales	1117|Cyanobacteria	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_3567087_8	1410609.JHVB01000001_gene2310	3.997e-08	59.0	COG4974@1|root,COG4974@2|Bacteria,2J5UZ@203691|Spirochaetes	203691|Spirochaetes	D	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_3567087_2	192952.MM_0729	4.683e-68	243.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	sCache_2
HKD1_k127_3567087_5	386456.JQKN01000002_gene2633	4.667e-27	113.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y01N@28890|Euryarchaeota	28890|Euryarchaeota	S	alkylhydroperoxidase like protein, AhpD family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_3567087_6	1035193.HMPREF9073_02230	1.68e-17	86.0	COG0599@1|root,COG1917@1|root,COG0599@2|Bacteria,COG1917@2|Bacteria,4NHTC@976|Bacteroidetes,1IMI9@117743|Flavobacteriia,1ESKJ@1016|Capnocytophaga	976|Bacteroidetes	S	ARD/ARD' family	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD,Cupin_2
HKD1_k127_3567087_1	335543.Sfum_0920	7.831e-85	291.0	COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	KQ	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_3590527_1	323259.Mhun_2196	7.187e-81	279.0	COG1136@1|root,arCOG00922@2157|Archaea,2XUH3@28890|Euryarchaeota,2NAKT@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3590527_0	323259.Mhun_2195	1.017e-144	469.0	COG0577@1|root,arCOG02312@2157|Archaea,2XUEE@28890|Euryarchaeota,2NBJ4@224756|Methanomicrobia	224756|Methanomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_3590527_2	273063.STK_17840	1.249e-19	101.0	COG2897@1|root,arCOG02019@2157|Archaea,2XQ1X@28889|Crenarchaeota	28889|Crenarchaeota	P	Sulfurtransferase	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_3592029_2	192952.MM_0592	1.201e-29	125.0	COG1300@1|root,arCOG01994@2157|Archaea,2XTS9@28890|Euryarchaeota,2N9U5@224756|Methanomicrobia	224756|Methanomicrobia	S	Stage II sporulation protein M	-	-	-	ko:K06384	-	-	-	-	ko00000	-	-	-	SpoIIM
HKD1_k127_3592029_0	304371.MCP_1853	7.949e-196	620.0	COG0008@1|root,arCOG00402@2157|Archaea,2XSUM@28890|Euryarchaeota,2N95X@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A0179	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HKD1_k127_3592029_1	192952.MM_2510	6.091e-66	236.0	COG1821@1|root,arCOG01592@2157|Archaea,2XXPE@28890|Euryarchaeota,2N9JU@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	6.3.4.24	ko:K06914	ko00680,map00680	-	R10902	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_3
HKD1_k127_3609720_0	402880.MmarC5_0992	1.263e-25	108.0	COG3527@1|root,arCOG03340@2157|Archaea,2XUAU@28890|Euryarchaeota,23RDZ@183939|Methanococci	183939|Methanococci	Q	PFAM alpha-acetolactate decarboxylase	-	-	4.1.1.5	ko:K01575	ko00650,ko00660,map00650,map00660	-	R02948	RC00812	ko00000,ko00001,ko01000	-	-	-	AAL_decarboxy
HKD1_k127_3661104_2	224325.AF_2410	1.428e-09	59.0	COG5440@1|root,arCOG01713@2157|Archaea,2XYFI@28890|Euryarchaeota,2469K@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized conserved protein (DUF2299)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2299
HKD1_k127_3661104_3	351160.RCIX895	3.876e-06	52.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,2NB7U@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3661104_4	1054217.TALC_01287	8.558e-05	47.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,241UR@183967|Thermoplasmata	183967|Thermoplasmata	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3661104_0	304371.MCP_2944	5.897e-15	76.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,2NB7U@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3661104_1	304371.MCP_2944	4.657e-10	60.0	COG1994@1|root,arCOG00614@2157|Archaea,2XX7B@28890|Euryarchaeota,2NB7U@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_366187_0	652103.Rpdx1_3244	1.079e-61	216.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria,3JX8P@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	PFAM flavin reductase domain protein, FMN-binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_366187_1	1116369.KB890024_gene3829	6.023e-09	57.0	COG1853@1|root,COG1853@2|Bacteria,1NB1B@1224|Proteobacteria,2U5NM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_3686106_7	397291.C804_05221	2.454e-18	89.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,27KR8@186928|unclassified Lachnospiraceae	186801|Clostridia	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_3686106_1	515635.Dtur_0719	3.764e-122	399.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_3686106_6	386456.JQKN01000001_gene2186	9.367e-22	96.0	COG1104@1|root,arCOG00066@2157|Archaea,2Y7J8@28890|Euryarchaeota,23NPK@183925|Methanobacteria	183925|Methanobacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_3686106_5	693661.Arcve_1026	5.477e-45	168.0	COG1370@1|root,arCOG00991@2157|Archaea,2XYFT@28890|Euryarchaeota,2471G@183980|Archaeoglobi	183980|Archaeoglobi	O	PUA domain containing protein	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
HKD1_k127_3686106_0	1379698.RBG1_1C00001G1453	9.195e-174	553.0	COG0112@1|root,COG0112@2|Bacteria,2NP28@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	GO:0001505,GO:0003674,GO:0003824,GO:0004372,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006545,GO:0006546,GO:0006563,GO:0006565,GO:0006730,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009056,GO:0009058,GO:0009063,GO:0009069,GO:0009070,GO:0009071,GO:0009987,GO:0016053,GO:0016054,GO:0016740,GO:0016741,GO:0016742,GO:0017144,GO:0019264,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042133,GO:0042135,GO:0042136,GO:0042737,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046395,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606,GO:1901607	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_3081,iIT341.HP0183	SHMT
HKD1_k127_3686106_2	1094980.Mpsy_1819	5.33e-101	336.0	COG2759@1|root,arCOG04538@2157|Archaea,2XTE0@28890|Euryarchaeota,2N9EP@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_3686106_8	224719.Abm4_1181	2.17e-17	89.0	COG4079@1|root,arCOG03213@2157|Archaea,2XW0G@28890|Euryarchaeota,23PI1@183925|Methanobacteria	183925|Methanobacteria	S	Uncharacterized protein conserved in archaea (DUF2121)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2121
HKD1_k127_3686106_4	351160.RCIX886	3.538e-46	174.0	COG0746@1|root,arCOG01872@2157|Archaea,2XWJR@28890|Euryarchaeota,2N9W7@224756|Methanomicrobia	224756|Methanomicrobia	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_3686106_3	269797.Mbar_A1745	1.641e-53	192.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,2N98T@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
HKD1_k127_3689637_5	511680.BUTYVIB_01172	1.066e-07	53.0	COG3635@1|root,COG3635@2|Bacteria,1TQ5S@1239|Firmicutes,248U6@186801|Clostridia	186801|Clostridia	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD1_k127_3689637_1	351160.RCIX2061	1.268e-80	274.0	COG4056@1|root,arCOG03225@2157|Archaea,2XW32@28890|Euryarchaeota,2N9IH@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Methyl-coenzyme M reductase operon protein C	mcrC	-	-	ko:K03421	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	MCR_C
HKD1_k127_3689637_0	269797.Mbar_A2900	2.91e-88	298.0	COG1798@1|root,arCOG04161@2157|Archaea,2XV63@28890|Euryarchaeota,2N986@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis	dphB	-	2.1.1.98	ko:K20215	-	-	R04481,R08468,R08469,R10306	RC00003,RC00190,RC01155,RC02136,RC02308	ko00000,ko01000	-	-	iAF692.Mbar_A2900	TP_methylase
HKD1_k127_3689637_6	304371.MCP_0701	1.029e-06	52.0	COG3609@1|root,arCOG04735@2157|Archaea,2XZTA@28890|Euryarchaeota,2NA26@224756|Methanomicrobia	224756|Methanomicrobia	K	transcriptional regulators containing the CopG Arc MetJ DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3689637_3	192952.MM_0756	7.609e-27	113.0	COG0720@1|root,arCOG02172@2157|Archaea,2XZ5K@28890|Euryarchaeota,2N9WF@224756|Methanomicrobia	224756|Methanomicrobia	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_3689637_2	639282.DEFDS_0939	5.06e-49	183.0	COG0603@1|root,COG0603@2|Bacteria,2GF7G@200930|Deferribacteres	200930|Deferribacteres	H	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD1_k127_3689637_4	1094980.Mpsy_2623	7.248e-09	62.0	arCOG03365@1|root,arCOG03365@2157|Archaea,2Y1W5@28890|Euryarchaeota,2NA3V@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_371722_1	269797.Mbar_A1892	2.151e-13	71.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_371722_2	269797.Mbar_A1892	5.811e-10	60.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_371722_0	591019.Shell_0344	7.508e-28	120.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_371722_3	679926.Mpet_2787	1.641e-07	56.0	arCOG09494@1|root,arCOG09494@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_375773_4	368407.Memar_2102	4.064e-30	122.0	COG0038@1|root,arCOG02569@2157|Archaea,2Y26D@28890|Euryarchaeota	28890|Euryarchaeota	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
HKD1_k127_375773_3	1459636.NTE_00646	1.048e-37	144.0	COG3324@1|root,arCOG04946@2157|Archaea,41T3T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_375773_2	402880.MmarC5_0835	4.784e-150	486.0	COG0477@1|root,arCOG00130@2157|Archaea,2Y8EJ@28890|Euryarchaeota,23RD7@183939|Methanococci	183939|Methanococci	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_375773_8	1122222.AXWR01000064_gene2216	1.866e-05	48.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_375773_7	1122222.AXWR01000064_gene2216	1.158e-07	55.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_375773_5	243232.MJ_1516	1.117e-19	92.0	COG2314@1|root,arCOG03293@2157|Archaea	2157|Archaea	O	PFAM TM2 domain containing protein	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,TM2
HKD1_k127_375773_0	635013.TherJR_0525	1.343e-264	829.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_375773_1	693661.Arcve_0328	5.534e-240	759.0	COG0365@1|root,arCOG01529@2157|Archaea,2XTAB@28890|Euryarchaeota,246QT@183980|Archaeoglobi	183980|Archaeoglobi	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_375773_9	269797.Mbar_A2808	0.0004857	43.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,2N9YN@224756|Methanomicrobia	224756|Methanomicrobia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_375773_6	931276.Cspa_c31080	1.665e-13	77.0	COG0457@1|root,COG0457@2|Bacteria,1UYZH@1239|Firmicutes,24BU9@186801|Clostridia,36F2E@31979|Clostridiaceae	186801|Clostridia	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_3776511_2	456442.Mboo_1254	7.297e-10	64.0	arCOG07763@1|root,arCOG07763@2157|Archaea	2157|Archaea	L	DNA polymerase activity	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	-
HKD1_k127_3776511_1	565033.GACE_0535	3.201e-13	75.0	arCOG06109@1|root,arCOG06109@2157|Archaea,2XYU6@28890|Euryarchaeota,246E2@183980|Archaeoglobi	183980|Archaeoglobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3776511_0	1094980.Mpsy_1891	2.954e-29	119.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,2N949@224756|Methanomicrobia	224756|Methanomicrobia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_381475_1	192952.MM_0918	5.645e-28	118.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYR2@28890|Euryarchaeota,2NBIG@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_381475_0	368407.Memar_1508	0.0	1112.0	COG1201@1|root,arCOG00557@2157|Archaea,2XSTH@28890|Euryarchaeota,2NA7T@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD1_k127_381475_2	1336233.JAEH01000040_gene4265	3.093e-07	52.0	COG0834@1|root,COG1301@1|root,COG0834@2|Bacteria,COG1301@2|Bacteria,1P22C@1224|Proteobacteria,1RSGY@1236|Gammaproteobacteria,2QBG7@267890|Shewanellaceae	1236|Gammaproteobacteria	P	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,SDF
HKD1_k127_384195_1	304371.MCP_0636	2.339e-54	193.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_384195_0	192952.MM_2009	5.516e-113	369.0	COG1117@1|root,arCOG00231@2157|Archaea,2XTJK@28890|Euryarchaeota,2N93D@224756|Methanomicrobia	224756|Methanomicrobia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_384195_2	373903.Hore_21540	9.616e-41	158.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,3WANJ@53433|Halanaerobiales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_3845905_5	192952.MM_1345	0.0002934	48.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
HKD1_k127_3845905_2	192952.MM_1344	1.723e-41	162.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,2N9SB@224756|Methanomicrobia	224756|Methanomicrobia	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_3845905_1	1094980.Mpsy_1937	9.453e-56	203.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,2N9QB@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
HKD1_k127_3845905_0	351160.RRC178	7.086e-65	224.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD1_k127_3845905_3	304371.MCP_1425	1.745e-39	153.0	arCOG04998@1|root,arCOG04998@2157|Archaea,2XZR1@28890|Euryarchaeota,2N9VB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3845905_4	269797.Mbar_A1179	6.434e-06	48.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,2N91M@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
HKD1_k127_386413_1	387631.Asulf_02198	7.846e-70	251.0	COG1269@1|root,arCOG04138@2157|Archaea,2XTQP@28890|Euryarchaeota,245R0@183980|Archaeoglobi	183980|Archaeoglobi	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_386413_3	269797.Mbar_A0392	3.929e-08	59.0	COG2811@1|root,arCOG03363@2157|Archaea,2Y73N@28890|Euryarchaeota,2NB93@224756|Methanomicrobia	224756|Methanomicrobia	C	H subunit	-	-	-	ko:K02107	ko00190,map00190	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V-ATPase_G_2
HKD1_k127_386413_0	1041930.Mtc_1074	3.49e-145	470.0	COG1850@1|root,arCOG04443@2157|Archaea,2XVBP@28890|Euryarchaeota,2N9IP@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3- phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase	rbcL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0902	RuBisCO_large,RuBisCO_large_N
HKD1_k127_386413_2	1151117.AJLF01000002_gene212	2.474e-30	121.0	COG1980@1|root,arCOG04180@2157|Archaea,2XTI0@28890|Euryarchaeota,24348@183968|Thermococci	183968|Thermococci	G	Catalyzes two subsequent steps in gluconeogenesis the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P)	fbp	-	3.1.3.11,4.1.2.13	ko:K01622	ko00010,ko00030,ko00051,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00003	R00762,R01068,R01070,R02568,R04780	RC00017,RC00438,RC00439	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_3
HKD1_k127_3879165_7	374847.Kcr_1543	2.51e-06	59.0	arCOG03270@1|root,arCOG03270@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TRAP_beta
HKD1_k127_3879165_1	351160.RCIX225	1.862e-85	291.0	COG0157@1|root,arCOG01482@2157|Archaea,2XTTY@28890|Euryarchaeota,2N950@224756|Methanomicrobia	224756|Methanomicrobia	H	Involved in the catabolism of quinolinic acid (QA)	nadC	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1867	QRPTase_C,QRPTase_N
HKD1_k127_3879165_2	269797.Mbar_A1866	1.04e-74	259.0	COG1712@1|root,arCOG00254@2157|Archaea,2XUNA@28890|Euryarchaeota,2NBJI@224756|Methanomicrobia	224756|Methanomicrobia	F	Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate	nadX	-	1.4.1.21	ko:K06989	ko00760,ko01100,map00760,map01100	-	R07407,R07410	RC02566	ko00000,ko00001,ko01000	-	-	-	DUF108,NAD_binding_3
HKD1_k127_3879165_6	706587.Desti_0660	2.008e-11	76.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,42NVZ@68525|delta/epsilon subdivisions,2WV1U@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Periplasmic copper-binding protein (NosD)	-	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD1_k127_3879165_0	243233.MCA1747	3.11e-91	316.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1XDUC@135618|Methylococcales	135618|Methylococcales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD1_k127_3879165_5	192952.MM_0822	1.066e-22	100.0	COG1872@1|root,arCOG04058@2157|Archaea,2XZV9@28890|Euryarchaeota,2N9YJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD1_k127_3879165_4	351160.RCIX285	1.046e-26	115.0	COG1658@1|root,arCOG01486@2157|Archaea,2Y0G2@28890|Euryarchaeota,2NA2F@224756|Methanomicrobia	224756|Methanomicrobia	L	metal ion binding	-	-	-	-	-	-	-	-	-	-	-	-	Toprim_4
HKD1_k127_3879165_3	1094980.Mpsy_0033	1.26e-38	147.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3893880_1	1197130.BAFM01000028_gene3109	6.916e-05	51.0	arCOG14112@1|root,arCOG14112@2157|Archaea,2Y0BR@28890|Euryarchaeota,23XT7@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3893880_0	1094508.Tsac_1745	8.03e-72	250.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,42EXA@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD1_k127_3920291_2	304371.MCP_1385	2.366e-57	207.0	COG0557@1|root,arCOG04686@2157|Archaea,2XT2E@28890|Euryarchaeota,2NA9N@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HKD1_k127_3920291_7	1499967.BAYZ01000036_gene2415	0.0001315	44.0	COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria	2|Bacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnb	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD1_k127_3920291_3	484770.UFO1_0085	1.173e-27	113.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,4H23F@909932|Negativicutes	1239|Firmicutes	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	-	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB
HKD1_k127_3920291_5	351160.RCIX2731	1.844e-20	94.0	COG0557@1|root,arCOG04686@2157|Archaea,2XT2E@28890|Euryarchaeota,2NA9N@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HKD1_k127_3920291_0	192952.MM_2033	7.059e-98	328.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,2N9RK@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_3920291_4	269797.Mbar_A3219	2.714e-25	107.0	arCOG04958@1|root,arCOG04958@2157|Archaea,2Y0MG@28890|Euryarchaeota,2N9YS@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3920291_1	1094980.Mpsy_1047	7.383e-71	245.0	COG1842@1|root,arCOG04782@2157|Archaea,2XU11@28890|Euryarchaeota,2N9P1@224756|Methanomicrobia	224756|Methanomicrobia	K	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD1_k127_39538_1	269797.Mbar_A0058	5.082e-77	265.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,2N93H@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
HKD1_k127_39538_0	351160.RRC443	6.23e-104	348.0	COG2108@1|root,arCOG00932@2157|Archaea,2XU78@28890|Euryarchaeota,2N929@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K07129	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_39538_2	1094980.Mpsy_1108	3.962e-37	141.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2NA22@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
HKD1_k127_39538_3	589924.Ferp_0626	6.085e-16	82.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_3982779_3	269797.Mbar_A0706	7.569e-51	186.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,2N90Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3982779_4	269797.Mbar_A0705	3.083e-35	139.0	COG4029@1|root,arCOG04901@2157|Archaea,2XZQS@28890|Euryarchaeota,2N9W1@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2102)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2102
HKD1_k127_3982779_2	269797.Mbar_A0704	1.203e-55	198.0	COG4050@1|root,arCOG04903@2157|Archaea,2XY68@28890|Euryarchaeota,2N9PJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2112
HKD1_k127_3982779_0	368407.Memar_2061	8.481e-172	548.0	COG1924@1|root,arCOG02679@2157|Archaea,2XU50@28890|Euryarchaeota,2N92J@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM ATPase, BadF BadG BcrA BcrD type	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD1_k127_3982779_5	304371.MCP_1064	3.844e-32	132.0	COG4051@1|root,arCOG04904@2157|Archaea,2Y0XT@28890|Euryarchaeota,2N9XA@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2113)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2113
HKD1_k127_3982779_1	351160.LRC174	7.637e-119	389.0	COG4052@1|root,arCOG03226@2157|Archaea,2XTWG@28890|Euryarchaeota,2N9D6@224756|Methanomicrobia	224756|Methanomicrobia	S	methanogenesis marker protein 7	-	-	-	-	-	-	-	-	-	-	-	-	MCR_C
HKD1_k127_3982779_6	269797.Mbar_A0700	0.0006648	44.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYR2@28890|Euryarchaeota,2NBIG@224756|Methanomicrobia	224756|Methanomicrobia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_4003504_7	269797.Mbar_A0965	1.401e-31	128.0	COG0517@1|root,arCOG00602@2157|Archaea,2XYM5@28890|Euryarchaeota,2N9RH@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_4003504_5	693661.Arcve_1479	4.91e-41	158.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,24692@183980|Archaeoglobi	183980|Archaeoglobi	S	signal transduction protein with CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_4003504_4	351160.RCIX901	3.244e-47	174.0	COG0521@1|root,arCOG00214@2157|Archaea,2XWJF@28890|Euryarchaeota,2N9SU@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM molybdenum cofactor synthesis domain	moaB	-	2.7.7.75	ko:K03638	ko00790,ko01100,map00790,map01100	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HKD1_k127_4003504_0	1094980.Mpsy_2091	4.506e-86	296.0	COG4012@1|root,arCOG04365@2157|Archaea,2XUWU@28890|Euryarchaeota,2N9HK@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative pyruvate format-lyase activating enzyme (DUF1786)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1786
HKD1_k127_4003504_2	192952.MM_0602	1.616e-63	224.0	COG0533@1|root,arCOG01183@2157|Archaea,arCOG01185@2157|Archaea,2XT07@28890|Euryarchaeota,2N9B7@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function	-	-	2.3.1.234,2.7.11.1	ko:K15904	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko01001,ko03016	-	-	-	Kdo,Peptidase_M22,RIO1
HKD1_k127_4003504_6	589924.Ferp_1127	3.736e-32	126.0	COG1581@1|root,arCOG01753@2157|Archaea,2XZH4@28890|Euryarchaeota,246B9@183980|Archaeoglobi	183980|Archaeoglobi	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
HKD1_k127_4003504_3	944481.JAFP01000001_gene602	2.619e-53	194.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,42R30@68525|delta/epsilon subdivisions,2WJT0@28221|Deltaproteobacteria,2M6N0@213113|Desulfurellales	28221|Deltaproteobacteria	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD1_k127_4003504_1	69014.TK0868	1.608e-63	220.0	COG0537@1|root,arCOG00419@2157|Archaea,2XWGT@28890|Euryarchaeota,242M1@183968|Thermococci	183968|Thermococci	F	Hit family	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HKD1_k127_404249_0	192952.MM_0293	3.98e-116	386.0	COG1599@1|root,arCOG01510@2157|Archaea,2XTYM@28890|Euryarchaeota,2N9GI@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM nucleic acid binding, OB-fold, tRNA helicase-type	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	-
HKD1_k127_404249_1	192952.MM_0292	4.729e-63	226.0	COG3390@1|root,arCOG02257@2157|Archaea,2XTM4@28890|Euryarchaeota,2N9JC@224756|Methanomicrobia	224756|Methanomicrobia	S	protein conserved in archaea	-	-	-	ko:K09746	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_4043585_2	536227.CcarbDRAFT_2512	1.751e-76	260.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,36DKA@31979|Clostridiaceae	186801|Clostridia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10005,iHN637.CLJU_RS10010	IlvC,IlvN
HKD1_k127_4043585_3	192952.MM_0669	5.184e-59	208.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD1_k127_4043585_0	1094980.Mpsy_0754	2.144e-238	749.0	COG0028@1|root,arCOG01998@2157|Archaea,2XT5F@28890|Euryarchaeota,2N9B4@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_4043585_1	351160.LRC535	1.77e-203	644.0	COG0119@1|root,arCOG02092@2157|Archaea,2XSZJ@28890|Euryarchaeota,2N9FH@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of pyruvate and acetyl- coenzyme A to form (R)-citramalate	cimA	-	2.3.1.182	ko:K09011	ko00290,ko00660,ko01100,ko01210,ko01230,map00290,map00660,map01100,map01210,map01230	M00535	R07399	RC00004,RC01205	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_4053493_6	192952.MM_2783	1.041e-60	220.0	COG0483@1|root,arCOG01349@2157|Archaea,2XUBB@28890|Euryarchaeota,2N9NZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_4053493_4	1094980.Mpsy_2900	1.762e-90	304.0	COG0061@1|root,arCOG01348@2157|Archaea,2XTP6@28890|Euryarchaeota,2N9MI@224756|Methanomicrobia	224756|Methanomicrobia	F	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD1_k127_4053493_9	1173024.KI912151_gene1981	5.771e-13	73.0	COG4095@1|root,COG4095@2|Bacteria,1G9AI@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM PQ loop repeat	-	-	-	ko:K15383	-	-	-	-	ko00000,ko02000	9.A.58.2	-	-	MtN3_slv,PQ-loop
HKD1_k127_4053493_7	1094980.Mpsy_2215	4.496e-58	206.0	COG4800@1|root,arCOG04375@2157|Archaea,2XXJS@28890|Euryarchaeota,2N9MB@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD1_k127_4053493_1	192952.MM_1362	1.325e-121	398.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV39@28890|Euryarchaeota,2N923@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC transporter, substrate-binding protein, aliphatic	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD1_k127_4053493_5	192952.MM_1361	6.301e-88	297.0	COG0600@1|root,arCOG00169@2157|Archaea,2XUAR@28890|Euryarchaeota,2N99H@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM binding-protein-dependent transport systems inner membrane component	ssuC	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_4053493_3	456442.Mboo_2448	9.041e-110	365.0	COG3276@1|root,arCOG01564@2157|Archaea,2XWBV@28890|Euryarchaeota,2N945@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM elongation factor Tu domain 2	-	-	-	-	-	-	-	-	-	-	-	-	GTP_EFTU_D2
HKD1_k127_4053493_2	269797.Mbar_A3624	3.188e-111	368.0	COG0547@1|root,arCOG02012@2157|Archaea,2XT3C@28890|Euryarchaeota,2N9AU@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_4053493_8	756883.Halar_2130	6.442e-38	150.0	COG0135@1|root,arCOG01983@2157|Archaea	2157|Archaea	E	Belongs to the TrpF family	trpF	-	4.2.1.20,5.3.1.24	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03509	RC00209,RC00210,RC00700,RC00701,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PRAI
HKD1_k127_4053493_0	1094980.Mpsy_2047	8.654e-139	455.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,2N9A9@224756|Methanomicrobia	224756|Methanomicrobia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_4061494_4	696369.KI912183_gene348	5.256e-71	241.0	COG1454@1|root,COG1454@2|Bacteria,1UY3E@1239|Firmicutes,25E9A@186801|Clostridia,264SJ@186807|Peptococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_4061494_1	269797.Mbar_A0784	4.172e-114	370.0	COG1454@1|root,arCOG00984@2157|Archaea,2XU9N@28890|Euryarchaeota,2NAJG@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Iron-containing alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001,ko:K13954	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_4061494_10	469617.FUAG_00976	1.55e-12	69.0	COG0655@1|root,COG0655@2|Bacteria,37A1W@32066|Fusobacteria	32066|Fusobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_4061494_3	484770.UFO1_0756	1.667e-85	286.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,4H3BA@909932|Negativicutes	909932|Negativicutes	S	Nadph-dependent fmn reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_4061494_5	304371.MCP_1381	3.389e-64	221.0	COG1733@1|root,arCOG01057@2157|Archaea,2XXSV@28890|Euryarchaeota,2NB0R@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM helix-turn-helix HxlR type	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_4061494_2	456442.Mboo_0406	9.047e-113	368.0	arCOG02290@1|root,arCOG02290@2157|Archaea,2XWJW@28890|Euryarchaeota,2N9PB@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_4061494_9	410359.Pcal_2030	1.949e-19	93.0	COG1525@1|root,arCOG03193@2157|Archaea	2157|Archaea	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4061494_6	1220534.B655_1041	6.298e-36	140.0	COG2164@1|root,arCOG04488@2157|Archaea	2157|Archaea	S	Cyclophilin-like	-	-	-	ko:K09143	-	-	-	-	ko00000	-	-	-	Cyclophil_like
HKD1_k127_4061494_8	161528.ED21_31279	1.626e-23	108.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,2K21H@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_4061494_0	1499967.BAYZ01000095_gene4132	4.833e-121	394.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD1_k127_4061494_7	192952.MM_0960	4.068e-29	119.0	COG0071@1|root,arCOG01838@2157|Archaea,2Y1IR@28890|Euryarchaeota,2NBAW@224756|Methanomicrobia	224756|Methanomicrobia	O	response to heat	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_4067821_4	224325.AF_1280	3.057e-70	244.0	COG0548@1|root,arCOG00862@2157|Archaea,2XTW9@28890|Euryarchaeota,245SQ@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_4067821_7	1220534.B655_0070	1.502e-21	99.0	COG3874@1|root,arCOG04972@2157|Archaea,2Y18Q@28890|Euryarchaeota,23P94@183925|Methanobacteria	183925|Methanobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HKD1_k127_4067821_8	386456.JQKN01000002_gene2561	1.026e-17	91.0	arCOG03505@1|root,arCOG03505@2157|Archaea,2Y1RG@28890|Euryarchaeota,23PWC@183925|Methanobacteria	183925|Methanobacteria	S	Protein of unknown function (DUF2953)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2953
HKD1_k127_4067821_2	335543.Sfum_0266	1.532e-93	314.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,42PQM@68525|delta/epsilon subdivisions,2WJIF@28221|Deltaproteobacteria,2MRCK@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	HTH_20,Methyltransf_31
HKD1_k127_4067821_1	555079.Toce_1201	1.782e-131	432.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,42FA1@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_4067821_5	634498.mru_1257	7.793e-50	183.0	COG1528@1|root,arCOG01095@2157|Archaea,2XXEN@28890|Euryarchaeota,23P20@183925|Methanobacteria	183925|Methanobacteria	P	Ferritin-like domain	-	-	1.16.3.2	ko:K02217	-	-	-	-	ko00000,ko01000	-	-	-	Ferritin
HKD1_k127_4067821_6	398512.JQKC01000010_gene94	7.858e-25	103.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3WKG3@541000|Ruminococcaceae	186801|Clostridia	C	PFAM Rubredoxin-type Fe(Cys)4 protein	rd	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD1_k127_4067821_0	1094980.Mpsy_0810	1.683e-141	462.0	COG1530@1|root,arCOG00321@2157|Archaea,2XU9U@28890|Euryarchaeota,2N9CZ@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM peptidase U62 modulator of DNA gyrase	-	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_4067821_3	351160.RCIX438	3.762e-76	259.0	COG0466@1|root,arCOG02160@2157|Archaea,2XTT0@28890|Euryarchaeota,2N9CG@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase S16 family	lon	-	3.4.21.53	ko:K04076	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AAA_32,Lon_C,Mg_chelatase
HKD1_k127_4077976_0	381764.Fnod_1302	6.084e-159	505.0	COG0369@1|root,COG1151@2|Bacteria,2GBYD@200918|Thermotogae	200918|Thermotogae	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	GO:0000302,GO:0003674,GO:0003824,GO:0004601,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009636,GO:0009987,GO:0010035,GO:0016209,GO:0016491,GO:0016661,GO:0016684,GO:0042221,GO:0042493,GO:0042542,GO:0046677,GO:0050418,GO:0050896,GO:0051716,GO:0055114,GO:0070887,GO:0097237,GO:0098754,GO:0098869,GO:1901700,GO:1990748	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
HKD1_k127_4077976_2	555079.Toce_1753	2.305e-60	217.0	COG1145@1|root,COG1145@2|Bacteria,1TPAZ@1239|Firmicutes,249NJ@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_6
HKD1_k127_4077976_1	565033.GACE_1943	6.221e-63	225.0	COG1810@1|root,arCOG02468@2157|Archaea,2XU42@28890|Euryarchaeota,24608@183980|Archaeoglobi	183980|Archaeoglobi	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
HKD1_k127_4077976_5	1121324.CLIT_2c03230	1.386e-14	74.0	COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia	186801|Clostridia	H	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
HKD1_k127_4077976_3	1121324.CLIT_2c03230	3.081e-50	184.0	COG2998@1|root,COG2998@2|Bacteria,1V9V8@1239|Firmicutes,25H3U@186801|Clostridia	186801|Clostridia	H	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
HKD1_k127_4077976_4	1270196.JCKI01000003_gene1875	7.19e-24	109.0	COG0671@1|root,COG0671@2|Bacteria,4NI23@976|Bacteroidetes	976|Bacteroidetes	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_4085713_0	304371.MCP_1267	3.134e-140	452.0	COG0111@1|root,arCOG01754@2157|Archaea,2XU9V@28890|Euryarchaeota,2N9DW@224756|Methanomicrobia	224756|Methanomicrobia	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_4085713_1	387631.Asulf_00300	1.614e-10	62.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD1_k127_4099874_2	589924.Ferp_2302	5.895e-24	104.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,246P3@183980|Archaeoglobi	183980|Archaeoglobi	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD1_k127_4099874_1	269797.Mbar_A0582	4.245e-36	151.0	COG3271@1|root,arCOG06761@2157|Archaea,2Y40P@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase C39 family	-	-	-	ko:K06992	-	-	-	-	ko00000	-	-	-	Peptidase_C39_2
HKD1_k127_4099874_0	522306.CAP2UW1_1998	3.756e-62	221.0	29VND@1|root,30H5P@2|Bacteria,1RBVN@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4102160_0	192952.MM_0246	6.958e-138	448.0	COG0075@1|root,arCOG00082@2157|Archaea,2XTWU@28890|Euryarchaeota,2N9EM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM aminotransferase class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_4102160_1	368408.Tpen_0899	1.679e-19	90.0	COG0164@1|root,arCOG04121@2157|Archaea,2XQWK@28889|Crenarchaeota	28889|Crenarchaeota	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_4102463_6	400668.Mmwyl1_1960	2.581e-15	81.0	COG0711@1|root,COG0711@2|Bacteria,1R6C0@1224|Proteobacteria,1S5EV@1236|Gammaproteobacteria,1XKA1@135619|Oceanospirillales	135619|Oceanospirillales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_4102463_0	102125.Xen7305DRAFT_00004720	4.884e-203	644.0	COG0056@1|root,COG0056@2|Bacteria,1G2ZY@1117|Cyanobacteria,3VMKR@52604|Pleurocapsales	1117|Cyanobacteria	C	ATP synthase alpha/beta chain, C terminal domain	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD1_k127_4102463_2	247490.KSU1_C1028	1.351e-87	298.0	COG0224@1|root,COG0224@2|Bacteria,2IZ25@203682|Planctomycetes	203682|Planctomycetes	C	ATP synthase	-	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD1_k127_4102463_5	269797.Mbar_A2470	2.882e-46	170.0	arCOG05248@1|root,arCOG05248@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4102463_4	192952.MM_3303	4.537e-56	208.0	COG0628@1|root,arCOG02642@2157|Archaea,2XXF0@28890|Euryarchaeota,2N9N3@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_4102463_1	1499967.BAYZ01000164_gene6677	1.811e-167	534.0	COG0426@1|root,COG0426@2|Bacteria,2NPHV@2323|unclassified Bacteria	2|Bacteria	C	Metallo-beta-lactamase superfamily	dfa1	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct,Flavodoxin_1,Lactamase_B
HKD1_k127_4102463_3	192952.MM_0586	1.66e-61	220.0	COG1085@1|root,arCOG00422@2157|Archaea,2XXR5@28890|Euryarchaeota,2N9KB@224756|Methanomicrobia	224756|Methanomicrobia	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_transf
HKD1_k127_4103774_0	368407.Memar_2342	9.756e-18	84.0	COG4895@1|root,arCOG04920@2157|Archaea,2Y0A3@28890|Euryarchaeota,2NB4K@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized conserved protein (DUF2196)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2196
HKD1_k127_4109587_0	697303.Thewi_1720	7.799e-206	664.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,42EJU@68295|Thermoanaerobacterales	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_4109587_1	589924.Ferp_0209	7.377e-09	62.0	arCOG05011@1|root,arCOG05011@2157|Archaea,2XV03@28890|Euryarchaeota,246JZ@183980|Archaeoglobi	183980|Archaeoglobi	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4127363_0	944480.ATUV01000002_gene40	4.831e-174	557.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,42N5M@68525|delta/epsilon subdivisions,2WIIV@28221|Deltaproteobacteria,2M6MV@213113|Desulfurellales	28221|Deltaproteobacteria	C	Aconitase family (aconitate hydratase)	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2763	Aconitase,Aconitase_C
HKD1_k127_4127363_1	269797.Mbar_A1088	7.715e-165	531.0	COG0343@1|root,arCOG00989@2157|Archaea,2XTFH@28890|Euryarchaeota,2N9F2@224756|Methanomicrobia	224756|Methanomicrobia	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_4127363_2	269797.Mbar_A0956	3.484e-19	94.0	COG1549@1|root,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
HKD1_k127_4197855_3	192952.MM_0729	1.34e-13	72.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	sCache_2
HKD1_k127_4197855_0	368407.Memar_2473	5.04e-17	85.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_4197855_1	521011.Mpal_1452	1.426e-16	81.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	sCache_2
HKD1_k127_4197855_4	521011.Mpal_2491	1.503e-13	75.0	arCOG09494@1|root,arCOG09494@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4197855_2	1444711.CCJF01000004_gene2422	2.694e-14	78.0	COG4974@1|root,COG4974@2|Bacteria,2JFCQ@204428|Chlamydiae	204428|Chlamydiae	D	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_4220994_1	1121422.AUMW01000026_gene368	5.21e-142	457.0	COG0067@1|root,COG0067@2|Bacteria,1TQX1@1239|Firmicutes,24AKF@186801|Clostridia,260EK@186807|Peptococcaceae	186801|Clostridia	E	PFAM Glutamine amidotransferase, class-II	-	-	-	-	-	-	-	-	-	-	-	-	GATase_2,GATase_6
HKD1_k127_4220994_0	1121468.AUBR01000046_gene1911	1.162e-249	777.0	COG0069@1|root,COG0069@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,42EK3@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the glutamate synthase family	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_7,Fer4_9,Glu_syn_central,Glu_synthase
HKD1_k127_4220994_2	693661.Arcve_1294	1.332e-08	57.0	COG0070@1|root,arCOG00096@2157|Archaea,2XW01@28890|Euryarchaeota,246HR@183980|Archaeoglobi	183980|Archaeoglobi	E	GXGXG motif	-	-	-	-	-	-	-	-	-	-	-	-	GXGXG
HKD1_k127_4221142_0	521011.Mpal_2625	1.877e-149	476.0	COG0685@1|root,arCOG04487@2157|Archaea,2XU03@28890|Euryarchaeota,2NAHD@224756|Methanomicrobia	224756|Methanomicrobia	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HKD1_k127_4221142_2	877455.Metbo_1398	2.056e-62	216.0	COG2193@1|root,arCOG01094@2157|Archaea,2Y3W0@28890|Euryarchaeota	28890|Euryarchaeota	P	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD1_k127_4221142_3	243231.GSU2309	6.817e-50	182.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1MUDN@1224|Proteobacteria,42N3H@68525|delta/epsilon subdivisions,2WJSC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	domain, Protein	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_4221142_1	269797.Mbar_A2298	2.157e-143	456.0	COG3369@1|root,arCOG03174@2157|Archaea,2XX0Q@28890|Euryarchaeota,2NAIG@224756|Methanomicrobia	224756|Methanomicrobia	S	SMART zinc finger, CDGSH-type domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_19,zf-CDGSH
HKD1_k127_4221142_5	868131.MSWAN_0372	6.658e-06	50.0	arCOG04838@1|root,arCOG04838@2157|Archaea,2Y1E7@28890|Euryarchaeota,23PTY@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4221142_4	868131.MSWAN_2227	5.062e-13	70.0	COG2146@1|root,arCOG02852@2157|Archaea,2XUZH@28890|Euryarchaeota	28890|Euryarchaeota	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Rieske_2
HKD1_k127_4226318_0	485915.Dret_0951	1.712e-35	140.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_4238077_2	1298880.AUEV01000010_gene2740	5.767e-34	138.0	2AWGV@1|root,31ND8@2|Bacteria,2IC8U@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4238077_1	717231.Flexsi_0270	1.677e-60	213.0	COG0778@1|root,COG0778@2|Bacteria,2GFSD@200930|Deferribacteres	200930|Deferribacteres	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4238077_3	351160.RRC171	1.247e-32	129.0	COG0310@1|root,arCOG03159@2157|Archaea,2XZGU@28890|Euryarchaeota,2NB7E@224756|Methanomicrobia	224756|Methanomicrobia	P	PDGLE domain	-	-	-	ko:K02007,ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	PDGLE
HKD1_k127_4238077_0	269797.Mbar_A2565	6.41e-98	325.0	COG0310@1|root,arCOG02248@2157|Archaea,2XWDU@28890|Euryarchaeota,2NACY@224756|Methanomicrobia	224756|Methanomicrobia	P	Cobalt uptake substrate-specific transmembrane region	-	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
HKD1_k127_4243128_0	323259.Mhun_0532	1.511e-19	97.0	arCOG04555@1|root,arCOG04555@2157|Archaea,2XUY2@28890|Euryarchaeota,2N9YH@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein CcmA involved in cell shape determination	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_424574_1	1123371.ATXH01000003_gene1893	2.82e-60	215.0	COG1926@1|root,COG1926@2|Bacteria	2|Bacteria	Q	phosphoribosyltransferase	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_424574_0	1041930.Mtc_0756	1.103e-160	518.0	COG0209@1|root,arCOG03713@1|root,arCOG03713@2157|Archaea,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota,2NAJJ@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HKD1_k127_4276252_3	247490.KSU1_D0773	1.42e-18	86.0	COG3335@1|root,COG3335@2|Bacteria,2IZSH@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_4276252_4	1218108.KB908303_gene2632	0.0002886	50.0	COG5513@1|root,COG5513@2|Bacteria,4NZ1B@976|Bacteroidetes	976|Bacteroidetes	S	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Inhibitor_I42
HKD1_k127_4276252_0	269797.Mbar_A0082	4.579e-120	394.0	COG0130@1|root,arCOG00987@2157|Archaea,2XTUE@28890|Euryarchaeota,2N99I@224756|Methanomicrobia	224756|Methanomicrobia	J	Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177,ko:K11131	ko03008,map03008	M00425	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03016,ko03032	-	-	-	DKCLD,PUA,TruB_C_2,TruB_N
HKD1_k127_4276252_1	1041930.Mtc_1349	8.749e-38	147.0	COG1102@1|root,arCOG01037@2157|Archaea,2XWPB@28890|Euryarchaeota,2N9PR@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
HKD1_k127_4276252_2	1094980.Mpsy_1121	1.602e-21	95.0	COG1422@1|root,arCOG02673@2157|Archaea,2XSX8@28890|Euryarchaeota,2N9PG@224756|Methanomicrobia	224756|Methanomicrobia	U	Integral membrane protein DUF106	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
HKD1_k127_4281312_2	693661.Arcve_2005	5.282e-41	153.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota,2475X@183980|Archaeoglobi	28890|Euryarchaeota	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_4281312_0	521011.Mpal_2784	2.233e-176	561.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota,2N971@224756|Methanomicrobia	224756|Methanomicrobia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_4281312_1	693661.Arcve_0689	1.842e-55	199.0	arCOG04451@1|root,arCOG04451@2157|Archaea,2XV98@28890|Euryarchaeota,246BK@183980|Archaeoglobi	183980|Archaeoglobi	K	Ribbon-helix-helix protein, copG family	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD1_k127_4281312_4	706434.HMPREF9429_01560	2.14e-06	54.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,4H2K7@909932|Negativicutes	909932|Negativicutes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_4281312_3	877455.Metbo_0485	4.216e-12	68.0	COG1142@1|root,arCOG01502@2157|Archaea,2XZ3T@28890|Euryarchaeota,23PPD@183925|Methanobacteria	183925|Methanobacteria	C	4Fe-4S dicluster domain	porF	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_3
HKD1_k127_4297296_0	1094980.Mpsy_2809	3.357e-66	235.0	COG0834@1|root,arCOG03643@2157|Archaea,2XUYP@28890|Euryarchaeota,2N96E@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM extracellular solute-binding protein family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3,sCache_2
HKD1_k127_4297296_2	521011.Mpal_2563	5.925e-43	162.0	COG0840@1|root,arCOG03007@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_4297296_1	877455.Metbo_1710	1.385e-62	233.0	arCOG10445@1|root,arCOG10445@2157|Archaea,2Y3V6@28890|Euryarchaeota	28890|Euryarchaeota	S	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	AAT
HKD1_k127_4320901_1	269797.Mbar_A0197	4.215e-72	256.0	COG2232@1|root,arCOG01595@2157|Archaea,2XXHX@28890|Euryarchaeota,2N9KN@224756|Methanomicrobia	224756|Methanomicrobia	S	ATP-grasp domain	-	-	-	ko:K06913	-	-	-	-	ko00000	-	-	-	ATP-grasp_3
HKD1_k127_4320901_2	1094980.Mpsy_0110	7.498e-61	214.0	COG1303@1|root,arCOG01857@2157|Archaea,2XV35@28890|Euryarchaeota,2N9MS@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
HKD1_k127_4320901_0	269797.Mbar_A3472	8.087e-274	859.0	COG1107@1|root,arCOG00429@2157|Archaea,2XTZ2@28890|Euryarchaeota,2N92F@224756|Methanomicrobia	224756|Methanomicrobia	L	acid binding OB-fold tRNA helicase-type	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHH,DnaJ_CXXCXGXG,S1,tRNA_anti-codon
HKD1_k127_4354167_1	1041930.Mtc_1154	4.591e-194	612.0	COG0443@1|root,arCOG03060@2157|Archaea,2XT86@28890|Euryarchaeota,2N91T@224756|Methanomicrobia	224756|Methanomicrobia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_4354167_8	138119.DSY3131	4.797e-30	126.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,26214@186807|Peptococcaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_4354167_2	351160.RCIX1971	8.202e-180	578.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_4354167_4	419665.Maeo_0572	1.562e-113	370.0	COG1117@1|root,arCOG00231@2157|Archaea,2XTJK@28890|Euryarchaeota,23QAI@183939|Methanococci	183939|Methanococci	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_4354167_7	1304866.K413DRAFT_4561	1.224e-42	165.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,36FX2@31979|Clostridiaceae	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_4354167_5	1238425.J07HQW2_01976	2.797e-53	200.0	COG0704@1|root,arCOG00318@2157|Archaea,2XUA4@28890|Euryarchaeota,23S6Y@183963|Halobacteria	183963|Halobacteria	K	Phosphate uptake regulator	phoU1	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
HKD1_k127_4354167_6	693661.Arcve_1661	3.292e-45	172.0	COG1515@1|root,arCOG00929@2157|Archaea,2XURE@28890|Euryarchaeota,24700@183980|Archaeoglobi	183980|Archaeoglobi	L	DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA	nfi	-	3.1.21.7	ko:K05982	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Endonuclease_5
HKD1_k127_4354167_9	1382356.JQMP01000004_gene338	7.812e-21	97.0	COG0350@1|root,COG0350@2|Bacteria,2G98B@200795|Chloroflexi,27Z9T@189775|Thermomicrobia	189775|Thermomicrobia	L	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
HKD1_k127_4354167_10	994573.T472_0205565	1.405e-05	48.0	2C539@1|root,33HA4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4354167_0	43989.cce_1253	1.16e-222	723.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,3KKRW@43988|Cyanothece	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_4354167_3	485913.Krac_5920	1.158e-179	571.0	COG0641@1|root,COG0641@2|Bacteria,2G74V@200795|Chloroflexi	200795|Chloroflexi	C	Iron-sulfur cluster-binding domain	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Radical_SAM,SPASM
HKD1_k127_4407533_12	1094980.Mpsy_1243	0.0004827	44.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_4407533_4	1094980.Mpsy_0967	8.287e-170	540.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9HE@224756|Methanomicrobia	224756|Methanomicrobia	F	Protein of unknown function (DUF1246)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
HKD1_k127_4407533_7	192952.MM_1978	1.948e-61	220.0	COG2218@1|root,arCOG00097@2157|Archaea,2XWD0@28890|Euryarchaeota,2NAVQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM glutamate synthase alpha subunit domain protein	-	-	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
HKD1_k127_4407533_2	192952.MM_1979	6.398e-218	689.0	COG1229@1|root,arCOG04461@2157|Archaea,2XV5V@28890|Euryarchaeota,2N9G0@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase subunit A	-	-	1.2.7.12	ko:K00200	ko00680,ko01100,ko01120,ko01130,ko01200,map00680,map01100,map01120,map01130,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_3
HKD1_k127_4407533_5	192952.MM_1980	5.195e-157	507.0	COG1029@1|root,arCOG01499@2157|Archaea,2XTPW@28890|Euryarchaeota,2NACR@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	fwdB-1	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdopterin
HKD1_k127_4407533_10	387631.Asulf_01598	7.02e-22	99.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,246AM@183980|Archaeoglobi	183980|Archaeoglobi	C	Formylmethanofuran dehydrogenase subunit D	-	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
HKD1_k127_4407533_6	224325.AF_0629	4.234e-64	223.0	COG0066@1|root,arCOG02230@2157|Archaea,2XTXJ@28890|Euryarchaeota,2465I@183980|Archaeoglobi	183980|Archaeoglobi	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_4407533_3	192952.MM_1489	1.125e-182	577.0	COG0473@1|root,arCOG01163@2157|Archaea,2XT99@28890|Euryarchaeota,2N918@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM isocitrate isopropylmalate dehydrogenase	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_4407533_9	693661.Arcve_1355	3.065e-23	100.0	COG2012@1|root,arCOG04258@2157|Archaea,2Y0EY@28890|Euryarchaeota,2479S@183980|Archaeoglobi	183980|Archaeoglobi	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
HKD1_k127_4407533_1	1094980.Mpsy_1006	2.718e-235	736.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU9Q@28890|Euryarchaeota,2N99Y@224756|Methanomicrobia	224756|Methanomicrobia	K	Belongs to the RNA polymerase beta chain family	rpoB1	-	2.7.7.6	ko:K03045	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3
HKD1_k127_4407533_0	351160.LRC356	8.522e-302	934.0	COG0085@1|root,arCOG01762@2157|Archaea,2XU1X@28890|Euryarchaeota,2N93R@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB2	-	2.7.7.6	ko:K03044	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_4407533_8	351160.LRC357	1.963e-31	124.0	COG0086@1|root,arCOG04257@2157|Archaea,2XTBZ@28890|Euryarchaeota,2N96G@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA1	-	2.7.7.6	ko:K03041	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD1_k127_4412895_0	357808.RoseRS_3394	9.173e-12	77.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HKD1_k127_4413634_1	644281.MFS40622_0251	3.269e-07	53.0	COG3398@1|root,arCOG02611@2157|Archaea,2XW64@28890|Euryarchaeota,23PZT@183939|Methanococci	183939|Methanococci	K	PFAM regulatory protein, ArsR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
HKD1_k127_4413634_0	926560.KE387023_gene1701	9.501e-140	465.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_4414610_0	56780.SYN_00298	9.372e-207	657.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42MEQ@68525|delta/epsilon subdivisions,2WIPF@28221|Deltaproteobacteria,2MQYI@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Carbohydrate phosphorylase	-	-	2.4.1.1,2.4.1.11	ko:K00688,ko:K16153	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R00292,R02111	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT3,GT35	-	DUF3417,Phosphorylase
HKD1_k127_4414610_8	269797.Mbar_A2035	5.194e-44	166.0	COG0622@1|root,arCOG01141@2157|Archaea,2XWQ0@28890|Euryarchaeota,2N9SN@224756|Methanomicrobia	224756|Methanomicrobia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD1_k127_4414610_5	351160.LRC255	5.691e-73	260.0	COG0794@1|root,arCOG00068@2157|Archaea,2XX86@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Sugar isomerase (SIS)	-	-	5.3.1.27	ko:K08094	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05339,R09780	RC00377	ko00000,ko00001,ko00002,ko01000	-	-	-	SIS
HKD1_k127_4414610_1	269797.Mbar_A1334	2.52e-152	488.0	COG1759@1|root,arCOG04346@2157|Archaea,2XUFR@28890|Euryarchaeota,2N9G6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
HKD1_k127_4414610_10	579137.Metvu_0885	1.64e-27	118.0	COG0131@1|root,arCOG04398@2157|Archaea,2XT2K@28890|Euryarchaeota,23QMR@183939|Methanococci	183939|Methanococci	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	GO:0000105,GO:0003674,GO:0003824,GO:0004424,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD1_k127_4414610_4	269797.Mbar_A2016	1.375e-76	289.0	arCOG03256@1|root,arCOG03256@2157|Archaea,2Y6XR@28890|Euryarchaeota,2NAP3@224756|Methanomicrobia	224756|Methanomicrobia	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
HKD1_k127_4414610_3	1094980.Mpsy_0958	5.684e-107	353.0	COG1348@1|root,arCOG00590@2157|Archaea,2XUNI@28890|Euryarchaeota,2N9FB@224756|Methanomicrobia	224756|Methanomicrobia	D	4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family	nifH-1	-	1.18.6.1,6.3.3.7	ko:K02588,ko:K21610	ko00625,ko00860,ko00910,ko01100,ko01120,map00625,map00860,map00910,map01100,map01120	M00175,M00836	R05185,R05496,R11628	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
HKD1_k127_4414610_2	269797.Mbar_A0348	1.978e-151	491.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N96K@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-1	-	6.3.5.12	ko:K22012	ko00860,map00860	M00836	R11627	-	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_4414610_9	192952.MM_3104	2.217e-31	127.0	COG3576@1|root,arCOG00518@2157|Archaea,2XYMW@28890|Euryarchaeota,2N9U6@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM pyridoxamine 5'-phosphate oxidase-related FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD1_k127_4414610_7	1094980.Mpsy_0196	7.903e-51	189.0	COG1234@1|root,arCOG00500@2157|Archaea,2XTUD@28890|Euryarchaeota,2NAES@224756|Methanomicrobia	224756|Methanomicrobia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_4414610_6	1041930.Mtc_1043	2.91e-61	214.0	COG0499@1|root,arCOG04137@2157|Archaea,2XT4S@28890|Euryarchaeota,2N9AH@224756|Methanomicrobia	224756|Methanomicrobia	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_4415066_0	5888.CAK91022	8.305e-44	169.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_4418749_1	311424.DhcVS_35	2.541e-86	294.0	COG0543@1|root,COG0543@2|Bacteria,2GAKZ@200795|Chloroflexi,34CQB@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
HKD1_k127_4418749_0	264732.Moth_2312	1.425e-297	938.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales	186801|Clostridia	C	Formate dehydrogenase alpha subunit	fdhA	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD1_k127_4428650_2	1094980.Mpsy_1486	2.637e-13	77.0	arCOG02542@1|root,arCOG03257@1|root,arCOG03267@1|root,arCOG02542@2157|Archaea,arCOG03257@2157|Archaea,arCOG03267@2157|Archaea	2157|Archaea	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
HKD1_k127_4428650_0	264732.Moth_0917	1.845e-165	530.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,42FC2@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_4428650_1	351160.RCIX298	7.775e-15	77.0	COG0071@1|root,arCOG01832@2157|Archaea,2XYW4@28890|Euryarchaeota,2N9V8@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_4429613_0	1220534.B655_0905	3.562e-16	80.0	COG0450@1|root,arCOG00312@2157|Archaea,2XTKD@28890|Euryarchaeota	28890|Euryarchaeota	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	-	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0009628,GO:0009636,GO:0009987,GO:0016209,GO:0016491,GO:0016684,GO:0042221,GO:0050896,GO:0051716,GO:0051920,GO:0055114,GO:0070482,GO:0070887,GO:0071453,GO:0097237,GO:0098754,GO:0098869,GO:1990748	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_4429613_5	176280.SE_1545	7.942e-09	59.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,4HHF8@91061|Bacilli,4GY3F@90964|Staphylococcaceae	91061|Bacilli	K	Belongs to the Fur family	perR	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_4429613_3	273068.TTE1767	1.425e-12	70.0	COG0735@1|root,COG0735@2|Bacteria,1V400@1239|Firmicutes,24JS4@186801|Clostridia,42GE8@68295|Thermoanaerobacterales	186801|Clostridia	P	Ferric uptake regulator, Fur family	perR	GO:0003674,GO:0003700,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2000374,GO:2001141	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_4429613_6	70601.3256870	2.798e-05	48.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,243QA@183968|Thermococci	183968|Thermococci	J	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD1_k127_4429613_2	370438.PTH_0724	1.383e-13	72.0	COG1458@1|root,COG1458@2|Bacteria	2|Bacteria	S	PINc domain ribonuclease	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	DUF3368,PIN_5
HKD1_k127_4429613_4	351160.RCIX2731	1.539e-10	62.0	COG0557@1|root,arCOG04686@2157|Archaea,2XT2E@28890|Euryarchaeota,2NA9N@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HKD1_k127_4429613_1	671143.DAMO_0850	2.971e-15	76.0	COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria	2|Bacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnb	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD1_k127_4444805_10	1094980.Mpsy_1484	2.01e-93	314.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,2N9IK@224756|Methanomicrobia	224756|Methanomicrobia	L	SMART DNA-directed DNA polymerase B	polB-1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
HKD1_k127_4444805_16	521460.Athe_2428	4.554e-25	109.0	COG0328@1|root,COG0328@2|Bacteria,1VI1T@1239|Firmicutes,24U8C@186801|Clostridia,42HK4@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM ribonuclease H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3,SWIM
HKD1_k127_4444805_11	456442.Mboo_1390	7.378e-88	301.0	COG2896@1|root,arCOG00930@2157|Archaea,2XT7P@28890|Euryarchaeota,2N9FQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD1_k127_4444805_24	827.JFJK01000015_gene497	2.409e-05	48.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,42NY7@68525|delta/epsilon subdivisions,2YNB3@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD1_k127_4444805_23	1227487.C474_05095	7.002e-06	59.0	COG4743@1|root,arCOG02884@2157|Archaea,2XU3K@28890|Euryarchaeota,23T5R@183963|Halobacteria	183963|Halobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1616
HKD1_k127_4444805_8	269797.Mbar_A0608	1.632e-110	366.0	COG0535@1|root,arCOG00938@2157|Archaea,2XZ9M@28890|Euryarchaeota,2NANF@224756|Methanomicrobia	224756|Methanomicrobia	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
HKD1_k127_4444805_4	1094980.Mpsy_1302	3.142e-191	610.0	COG4065@1|root,arCOG04866@2157|Archaea,2XVGV@28890|Euryarchaeota,2N9CU@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2114)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2114
HKD1_k127_4444805_7	1094980.Mpsy_3012	6.988e-113	372.0	COG3252@1|root,arCOG02675@2157|Archaea,2XUB2@28890|Euryarchaeota,2N98S@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible interconversion of 5-formyl- H(4)MPT to methenyl-H(4)MPT(	mch	-	3.5.4.27	ko:K01499	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03464	RC01870	ko00000,ko00001,ko00002,ko01000	-	-	-	MCH
HKD1_k127_4444805_18	593750.Metfor_0759	1.14e-17	94.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7N5@28890|Euryarchaeota,2NB3I@224756|Methanomicrobia	224756|Methanomicrobia	T	PBS lyase HEAT-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD1_k127_4444805_13	880072.Desac_2419	1.555e-63	228.0	COG0731@1|root,COG0731@2|Bacteria,1QG36@1224|Proteobacteria,42M82@68525|delta/epsilon subdivisions,2WKGK@28221|Deltaproteobacteria,2MQEH@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_4444805_20	1094980.Mpsy_2197	3.32e-12	70.0	COG4023@1|root,arCOG02957@2157|Archaea,2Y6WB@28890|Euryarchaeota,2NA5T@224756|Methanomicrobia	224756|Methanomicrobia	U	but it may be involved in stabilization of the trimeric complex	secG	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
HKD1_k127_4444805_22	1094980.Mpsy_1243	2.295e-10	64.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_4444805_2	426368.MmarC7_0975	8.841e-234	733.0	COG0591@1|root,arCOG01316@2157|Archaea,2XU91@28890|Euryarchaeota,23RJP@183939|Methanococci	183939|Methanococci	P	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD1_k127_4444805_19	386456.JQKN01000001_gene1916	5.541e-14	75.0	arCOG04899@1|root,arCOG04899@2157|Archaea,2Y1RM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4444805_15	269797.Mbar_A1859	3.251e-39	149.0	COG0526@1|root,arCOG01972@2157|Archaea,2XZVP@28890|Euryarchaeota,2NA27@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
HKD1_k127_4444805_1	269797.Mbar_A2708	0.0	1052.0	COG0556@1|root,arCOG04748@2157|Archaea,2XTM8@28890|Euryarchaeota,2NAF4@224756|Methanomicrobia	224756|Methanomicrobia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_4444805_3	192952.MM_3290	2.299e-229	719.0	COG0322@1|root,arCOG04753@2157|Archaea,2XTH1@28890|Euryarchaeota,2N9EV@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
HKD1_k127_4444805_0	269797.Mbar_A2710	0.0	1561.0	COG0178@1|root,arCOG04694@2157|Archaea,2XTDU@28890|Euryarchaeota,2N9EN@224756|Methanomicrobia	224756|Methanomicrobia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_4444805_17	70601.3258013	1.098e-22	110.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,243E3@183968|Thermococci	183968|Thermococci	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
HKD1_k127_4444805_12	269797.Mbar_A2320	1.2e-70	246.0	COG0171@1|root,arCOG00069@2157|Archaea,2XT7M@28890|Euryarchaeota,2N9N9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
HKD1_k127_4444805_14	269797.Mbar_A1897	1.482e-56	202.0	COG2061@1|root,arCOG04396@2157|Archaea,2XWMD@28890|Euryarchaeota,2N9PF@224756|Methanomicrobia	224756|Methanomicrobia	E	amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4444805_9	192952.MM_2713	5.923e-102	341.0	COG0460@1|root,arCOG01351@2157|Archaea,2XSWF@28890|Euryarchaeota,2N91A@224756|Methanomicrobia	224756|Methanomicrobia	E	homoserine dehydrogenase	thrA	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
HKD1_k127_4444805_5	1094980.Mpsy_0817	6.351e-190	608.0	COG1793@1|root,arCOG01347@2157|Archaea,2XTCK@28890|Euryarchaeota,2N968@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD1_k127_4444805_6	269797.Mbar_A3507	6.699e-148	479.0	COG0141@1|root,arCOG04352@2157|Archaea,2XT6M@28890|Euryarchaeota,2N985@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_4444805_21	56780.SYN_00469	9.222e-12	65.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,42RFX@68525|delta/epsilon subdivisions,2WN92@28221|Deltaproteobacteria,2MQDS@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_4466170_2	1047013.AQSP01000100_gene580	4.783e-16	83.0	COG5014@1|root,COG5014@2|Bacteria	2|Bacteria	-	-	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_4466170_1	390874.Tpet_1795	4.642e-20	93.0	COG5014@1|root,COG5014@2|Bacteria	2|Bacteria	-	-	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_4466170_0	390874.Tpet_1795	1.428e-40	159.0	COG5014@1|root,COG5014@2|Bacteria	2|Bacteria	-	-	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_4466170_3	70601.3256870	2.613e-08	56.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,243QA@183968|Thermococci	183968|Thermococci	J	Zn-dependent metallo-hydrolase RNA specificity domain	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD1_k127_4475883_0	472759.Nhal_3096	9.976e-288	905.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_4475883_3	368407.Memar_1367	1.268e-11	65.0	COG1830@1|root,arCOG04044@2157|Archaea,2XSY2@28890|Euryarchaeota,2N9FM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	2.2.1.11,4.1.2.13	ko:K16305	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R10049,R10050	RC00438,RC00439,RC02301,RC03034	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD1_k127_4475883_1	747365.Thena_0232	7.608e-103	343.0	COG1105@1|root,COG1105@2|Bacteria,1TQ36@1239|Firmicutes,249RK@186801|Clostridia	186801|Clostridia	H	Belongs to the carbohydrate kinase PfkB family. LacC subfamily	-	-	2.7.1.11	ko:K16370	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HKD1_k127_4475883_2	1123288.SOV_2c11770	1.115e-79	274.0	COG0491@1|root,COG0491@2|Bacteria,1V2XF@1239|Firmicutes	1239|Firmicutes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_4501201_1	572546.Arcpr_0107	2.338e-65	236.0	COG1252@1|root,arCOG01067@2157|Archaea,2XTXM@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1252 NADH dehydrogenase, FAD-containing subunit	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_4501201_0	1094980.Mpsy_1018	3.498e-84	285.0	COG0476@1|root,arCOG01676@2157|Archaea,2XTYV@28890|Euryarchaeota,2N9IZ@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM UBA THIF-type NAD FAD binding protein	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1238	ThiF
HKD1_k127_4508647_1	1094980.Mpsy_2177	4.193e-142	460.0	COG3635@1|root,arCOG01696@2157|Archaea,2XU1U@28890|Euryarchaeota,2N95W@224756|Methanomicrobia	224756|Methanomicrobia	G	phosphoglycerate mutase	apgM	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD1_k127_4508647_6	192952.MM_2179	3.807e-21	99.0	COG1617@1|root,arCOG02197@2157|Archaea,2XXRY@28890|Euryarchaeota,2N9VU@224756|Methanomicrobia	224756|Methanomicrobia	S	KEOPS complex Cgi121-like subunit	-	-	-	ko:K09119	-	-	-	-	ko00000,ko03016	-	-	-	CGI-121
HKD1_k127_4508647_5	1094980.Mpsy_0962	8.591e-47	175.0	COG4749@1|root,arCOG04411@2157|Archaea,2XT50@28890|Euryarchaeota,2N9VH@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized protein conserved in archaea (DUF2150)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2150
HKD1_k127_4508647_2	304371.MCP_2363	2.341e-95	320.0	COG0024@1|root,arCOG01001@2157|Archaea,2XT8G@28890|Euryarchaeota,2N94S@224756|Methanomicrobia	224756|Methanomicrobia	E	Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val)	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_4508647_3	192952.MM_1500	5.162e-93	318.0	COG0006@1|root,arCOG01000@2157|Archaea,2XTQI@28890|Euryarchaeota,2N9FN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM peptidase M24	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_4508647_4	269797.Mbar_A0675	5.516e-86	292.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,2NA43@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
HKD1_k127_4508647_7	572546.Arcpr_0963	1.697e-17	82.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
HKD1_k127_4508647_0	748727.CLJU_c04160	2.805e-155	500.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	maeB	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS18940	Malic_M,malic
HKD1_k127_4573343_5	604354.TSIB_0718	5.893e-76	259.0	COG0477@1|root,arCOG00143@2157|Archaea,2Y8EH@28890|Euryarchaeota,245MX@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4573343_8	573064.Mefer_0871	1.66e-42	159.0	COG0477@1|root,arCOG00143@2157|Archaea,2XUTR@28890|Euryarchaeota,23RHP@183939|Methanococci	183939|Methanococci	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_4573343_3	456442.Mboo_2397	2.663e-116	385.0	COG1819@1|root,arCOG01393@2157|Archaea	2157|Archaea	CG	Glycosyltransferase 28 domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_trans_1_3
HKD1_k127_4573343_11	391623.TERMP_00723	3.914e-31	131.0	COG2129@1|root,arCOG01145@2157|Archaea,2XW7S@28890|Euryarchaeota,242PU@183968|Thermococci	183968|Thermococci	S	Metallophosphoesterase, calcineurin superfamily	-	-	-	ko:K07096	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_4573343_12	269797.Mbar_A2071	1.844e-25	111.0	COG0426@1|root,arCOG00509@2157|Archaea,2XYDW@28890|Euryarchaeota,2N9PY@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_1
HKD1_k127_4573343_2	56780.SYN_01225	1.261e-117	381.0	COG1251@1|root,COG1251@2|Bacteria,1MW58@1224|Proteobacteria,42PQD@68525|delta/epsilon subdivisions,2WKAI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	nitrite sulfite reductase, hemoprotein beta-component, ferrodoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD1_k127_4573343_14	1382306.JNIM01000001_gene1283	1.973e-07	57.0	2EV68@1|root,33NM1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4573343_1	351160.RCIX2455	3.35e-157	505.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N92K@224756|Methanomicrobia	224756|Methanomicrobia	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C- terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates	pan	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
HKD1_k127_4573343_9	269797.Mbar_A0621	4.361e-39	151.0	COG1813@1|root,arCOG01863@2157|Archaea,2XXND@28890|Euryarchaeota,2NBGT@224756|Methanomicrobia	224756|Methanomicrobia	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K03627	-	-	-	-	ko00000	-	-	-	HTH_3
HKD1_k127_4573343_7	351160.RCIX2453	2.372e-49	182.0	COG0009@1|root,arCOG01952@2157|Archaea,2XVGC@28890|Euryarchaeota,2N9VK@224756|Methanomicrobia	224756|Methanomicrobia	J	TIGRFAM Sua5 YciO YrdC YwlC family protein	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD1_k127_4573343_4	192952.MM_2229	5.398e-109	362.0	COG1665@1|root,arCOG01831@2157|Archaea,2XVY6@28890|Euryarchaeota,2N92D@224756|Methanomicrobia	224756|Methanomicrobia	S	DNA polymerase beta domain protein region	-	-	-	ko:K09717	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_4573343_0	269797.Mbar_A3188	1.128e-195	621.0	COG0213@1|root,arCOG02013@2157|Archaea,2XT19@28890|Euryarchaeota,2N9C6@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO	deoA	-	2.4.2.57	ko:K18931	-	-	R10836,R10837,R10838	RC00063	ko00000,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,Molydop_binding,PYNP_C
HKD1_k127_4573343_6	643648.Slip_1205	5.862e-72	252.0	COG0123@1|root,COG0123@2|Bacteria,1VX2J@1239|Firmicutes,251VB@186801|Clostridia	186801|Clostridia	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD1_k127_4573343_10	439481.Aboo_0164	3.447e-37	151.0	COG1578@1|root,arCOG04410@2157|Archaea,2XWGU@28890|Euryarchaeota,3F2KN@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function DUF89	-	-	-	ko:K09116	-	-	-	-	ko00000	-	-	-	DUF89
HKD1_k127_4573343_13	224719.Abm4_1640	2.459e-22	104.0	COG2047@1|root,arCOG00348@2157|Archaea,2XSX4@28890|Euryarchaeota,23P1D@183925|Methanobacteria	183925|Methanobacteria	S	PAC2 family	-	-	-	ko:K07159	-	-	-	-	ko00000	-	-	-	PAC2
HKD1_k127_4623643_1	1041930.Mtc_1570	4.301e-130	430.0	COG0470@1|root,arCOG00470@2157|Archaea,2XT81@28890|Euryarchaeota,2N94D@224756|Methanomicrobia	224756|Methanomicrobia	L	Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA	rfcL	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
HKD1_k127_4623643_3	192952.MM_2842	1.849e-15	81.0	COG3467@1|root,arCOG00520@2157|Archaea,2Y70J@28890|Euryarchaeota,2NB2C@224756|Methanomicrobia	224756|Methanomicrobia	S	pyridoxamine 5'-phosphate oxidase-related FMN-binding	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD1_k127_4623643_0	1094980.Mpsy_0927	3.84e-217	683.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_4623643_2	1031288.AXAA01000011_gene621	9.513e-39	149.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_4637045_0	1210908.HSB1_06020	1.61e-46	175.0	COG0438@1|root,arCOG01411@2157|Archaea,2XUFU@28890|Euryarchaeota,23U4A@183963|Halobacteria	183963|Halobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_4637045_1	717606.PaecuDRAFT_3115	7.223e-09	59.0	2EPGA@1|root,33H2X@2|Bacteria,1TZ9V@1239|Firmicutes,4I8HK@91061|Bacilli,26ZX5@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4644989_0	387631.Asulf_00266	8.125e-95	317.0	arCOG02763@1|root,arCOG02763@2157|Archaea,2Y8CF@28890|Euryarchaeota	28890|Euryarchaeota	P	COG2217 Cation transport ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_4644989_3	869210.Marky_1036	1.993e-12	68.0	COG3350@1|root,COG3350@2|Bacteria,1WN5Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HKD1_k127_4644989_4	1122201.AUAZ01000005_gene623	3.68e-05	49.0	COG3462@1|root,COG3462@2|Bacteria,1NGXC@1224|Proteobacteria,1SGF3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Short C-terminal domain	-	-	-	ko:K08982	-	-	-	-	ko00000	-	-	-	SHOCT
HKD1_k127_4644989_1	368407.Memar_1503	2.332e-18	87.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	DnaJ,Fer4_13,Fer4_15
HKD1_k127_4644989_2	521011.Mpal_1953	8.175e-14	76.0	arCOG03390@1|root,arCOG03390@2157|Archaea,2Y08K@28890|Euryarchaeota,2N9YI@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4661345_2	338969.Rfer_0173	9.366e-21	96.0	COG3874@1|root,COG3874@2|Bacteria,1N4RT@1224|Proteobacteria	1224|Proteobacteria	S	Sporulation protein YtfJ (Spore_YtfJ)	-	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HKD1_k127_4661345_0	760568.Desku_0170	2.592e-160	516.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,260UB@186807|Peptococcaceae	186801|Clostridia	C	PFAM Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	ACT_4,Malic_M,malic
HKD1_k127_4661345_3	572546.Arcpr_0963	9.476e-17	84.0	COG1552@1|root,arCOG04049@2157|Archaea,2Y177@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	rpl40e	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L40e
HKD1_k127_4661345_1	269797.Mbar_A0675	1.656e-40	153.0	COG1646@1|root,arCOG01085@2157|Archaea,2XTEC@28890|Euryarchaeota,2NA43@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
HKD1_k127_4661598_0	1094980.Mpsy_0939	2.082e-89	313.0	COG0644@1|root,arCOG00570@2157|Archaea,2Y2Q7@28890|Euryarchaeota,2NAKJ@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A1603	FAD_binding_3
HKD1_k127_4661598_1	1038860.AXAP01000007_gene6051	2.882e-50	186.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2TVJ0@28211|Alphaproteobacteria,3JTA5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD1_k127_4662723_3	436229.JOEH01000013_gene5780	7.509e-07	53.0	2DZA9@1|root,32V71@2|Bacteria,2IF7X@201174|Actinobacteria,2NM2J@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4662723_2	368407.Memar_1026	8.839e-53	193.0	COG0500@1|root,arCOG04989@2157|Archaea,2Y0ZS@28890|Euryarchaeota,2N9SX@224756|Methanomicrobia	224756|Methanomicrobia	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_4662723_1	224325.AF_1724	2.644e-64	232.0	COG1397@1|root,arCOG04448@2157|Archaea,2XV15@28890|Euryarchaeota,245ZY@183980|Archaeoglobi	183980|Archaeoglobi	O	PFAM ADP-ribosylation Crystallin J1	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_4662723_0	269797.Mbar_A2001	3.601e-84	284.0	COG0002@1|root,arCOG00495@2157|Archaea,2XTC1@28890|Euryarchaeota,2N9EF@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_4673482_3	269797.Mbar_A0003	7.737e-118	385.0	COG0252@1|root,arCOG01924@2157|Archaea,2XTN1@28890|Euryarchaeota,2N97V@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD1_k127_4673482_9	1094980.Mpsy_2090	1.142e-64	226.0	COG0197@1|root,arCOG04113@2157|Archaea,2XTHT@28890|Euryarchaeota,2N9MZ@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the universal ribosomal protein uL16 family	rpl10e	-	-	ko:K02866	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD1_k127_4673482_7	269797.Mbar_A1372	1.377e-81	275.0	COG1601@1|root,arCOG01640@2157|Archaea,2XTVZ@28890|Euryarchaeota,2N9JI@224756|Methanomicrobia	224756|Methanomicrobia	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2b	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	TRAM,eIF-5_eIF-2B
HKD1_k127_4673482_8	589924.Ferp_0887	6.817e-78	268.0	COG1478@1|root,arCOG02714@2157|Archaea,2XTHI@28890|Euryarchaeota,245SP@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives	cofE	-	6.3.2.31,6.3.2.34	ko:K12234	ko00680,ko01120,map00680,map01120	M00378	R09399,R09400	RC00064,RC00090,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_ligase
HKD1_k127_4673482_11	693661.Arcve_1619	4.749e-39	154.0	COG1920@1|root,arCOG04472@2157|Archaea,2XX3C@28890|Euryarchaeota,24697@183980|Archaeoglobi	183980|Archaeoglobi	H	Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor	cofC	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
HKD1_k127_4673482_10	192952.MM_2375	8.5e-59	208.0	COG2150@1|root,arCOG02316@2157|Archaea,2XWH9@28890|Euryarchaeota,2N9NE@224756|Methanomicrobia	224756|Methanomicrobia	S	regulator of amino acid metabolism, contains ACT domain	-	-	-	ko:K07103	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_4673482_1	589924.Ferp_0687	9.913e-126	412.0	COG1223@1|root,arCOG04163@2157|Archaea,2XUPW@28890|Euryarchaeota,245PY@183980|Archaeoglobi	183980|Archaeoglobi	O	Belongs to the AAA ATPase family	-	-	-	ko:K07392	-	-	-	-	ko00000	-	-	-	AAA
HKD1_k127_4673482_13	1094980.Mpsy_0217	1.138e-16	85.0	arCOG04925@1|root,arCOG04925@2157|Archaea,2Y4G0@28890|Euryarchaeota,2NB7V@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4673482_6	304371.MCP_0225	1.943e-84	287.0	COG0289@1|root,arCOG04393@2157|Archaea,2XTJU@28890|Euryarchaeota,2N9BV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD1_k127_4673482_4	192952.MM_1201	1.13e-115	379.0	COG0329@1|root,arCOG04172@2157|Archaea,2XSZX@28890|Euryarchaeota,2N99W@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_4673482_14	387631.Asulf_00688	5.861e-15	76.0	COG1383@1|root,arCOG01885@2157|Archaea,2Y07I@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eS17 family	rps17e	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
HKD1_k127_4673482_5	269797.Mbar_A3501	1.529e-90	314.0	COG0351@1|root,arCOG00020@2157|Archaea,2XSW8@28890|Euryarchaeota,2N9G9@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Phosphomethylpyrimidine kinase type-1	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K21219	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
HKD1_k127_4673482_12	877455.Metbo_0442	9.365e-19	91.0	COG2083@1|root,arCOG01921@2157|Archaea,2Y13G@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the UPF0216 family	-	-	-	ko:K09737	-	-	-	-	ko00000	-	-	-	DUF61
HKD1_k127_4673482_2	192952.MM_1873	1.117e-119	396.0	COG1078@1|root,arCOG04430@2157|Archaea,2XUT7@28890|Euryarchaeota,2N9CT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_4673482_0	192952.MM_1844	7.447e-141	460.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2N92Q@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrD may act as the catalytic subunit	hdrD	GO:0003674,GO:0003824,GO:0006091,GO:0008150,GO:0008152,GO:0009058,GO:0009061,GO:0009987,GO:0015947,GO:0015948,GO:0015975,GO:0015980,GO:0016491,GO:0016667,GO:0043446,GO:0043447,GO:0044237,GO:0044249,GO:0045333,GO:0051912,GO:0055114,GO:0071704,GO:1901576	1.8.98.1	ko:K08264	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	-	R04540	RC00011	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
HKD1_k127_4725867_1	1094980.Mpsy_1028	3.974e-152	489.0	COG0119@1|root,arCOG02093@2157|Archaea,2XVVR@28890|Euryarchaeota,2N9C3@224756|Methanomicrobia	224756|Methanomicrobia	E	HMGL-like	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_4725867_2	368407.Memar_2221	1.395e-50	185.0	COG0647@1|root,arCOG04221@2157|Archaea	2157|Archaea	G	sugar phosphatases of the HAD superfamily	-	-	3.1.3.41	ko:K01101,ko:K02566	ko00627,ko01120,map00627,map01120	-	R03024	RC00151	ko00000,ko00001,ko01000	-	-	-	Hydrolase_6,Hydrolase_like
HKD1_k127_4725867_4	456442.Mboo_0281	1.225e-09	62.0	COG0647@1|root,arCOG04221@2157|Archaea,2XTCH@28890|Euryarchaeota	28890|Euryarchaeota	G	sugar phosphatases of the HAD superfamily	-	-	-	ko:K02566	-	-	-	-	ko00000	-	-	-	Hydrolase_6,Hydrolase_like
HKD1_k127_4725867_3	693661.Arcve_0697	8.633e-44	161.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota,2475X@183980|Archaeoglobi	28890|Euryarchaeota	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_4725867_0	521011.Mpal_2784	1.858e-179	569.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota,2N971@224756|Methanomicrobia	224756|Methanomicrobia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_4736589_0	395961.Cyan7425_1816	4.008e-51	185.0	COG0590@1|root,COG0590@2|Bacteria,1G534@1117|Cyanobacteria,3KHPY@43988|Cyanothece	1117|Cyanobacteria	FJ	PFAM CMP dCMP deaminase zinc-binding	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	MafB19-deam,dCMP_cyt_deam_1
HKD1_k127_4736589_2	386456.JQKN01000002_gene2764	1.343e-18	92.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota	28890|Euryarchaeota	T	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	tspO	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD1_k127_4736589_3	593750.Metfor_2246	6.612e-05	46.0	COG0417@1|root,arCOG07763@1|root,arCOG00329@2157|Archaea,arCOG07763@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
HKD1_k127_4736589_1	877455.Metbo_0399	9.488e-41	156.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y55W@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4764490_2	224719.Abm4_0888	0.0005913	44.0	arCOG04838@1|root,arCOG04838@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4764490_1	443598.AUFA01000051_gene28	1.009e-07	62.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,3JUX4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_4764490_0	269797.Mbar_A0582	5.077e-34	144.0	COG3271@1|root,arCOG06761@2157|Archaea,2Y40P@28890|Euryarchaeota	28890|Euryarchaeota	S	Peptidase C39 family	-	-	-	ko:K06992	-	-	-	-	ko00000	-	-	-	Peptidase_C39_2
HKD1_k127_4764490_3	319795.Dgeo_2727	0.000958	45.0	COG0735@1|root,COG0735@2|Bacteria,1WJ7H@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Belongs to the Fur family	-	-	-	ko:K03711,ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_4781875_0	323259.Mhun_1064	9.661e-14	76.0	arCOG09494@1|root,arCOG09494@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4790334_1	1278306.KB906906_gene287	6.11e-42	156.0	COG1126@1|root,COG1126@2|Bacteria,378SG@32066|Fusobacteria	32066|Fusobacteria	E	K02028 polar amino acid transport system ATP-binding protein	artM	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD1_k127_4790334_0	1232437.KL661971_gene4894	9.008e-71	251.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,42SUF@68525|delta/epsilon subdivisions,2WPJU@28221|Deltaproteobacteria,2MKU8@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,4.3.1.12	ko:K01750,ko:K19244	ko00250,ko00330,ko00430,ko01100,ko01110,ko01130,ko01230,map00250,map00330,map00430,map01100,map01110,map01130,map01230	-	R00396,R00671	RC00008,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HKD1_k127_4790334_2	321846.PS417_09715	3.669e-22	105.0	COG1748@1|root,COG1748@2|Bacteria,1QXB2@1224|Proteobacteria	1224|Proteobacteria	E	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4848817_1	1041930.Mtc_1354	1.093e-115	380.0	COG2144@1|root,arCOG00640@2157|Archaea,2XTU9@28890|Euryarchaeota,2N979@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM AIR synthase related protein	-	-	-	ko:K07123	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_4848817_3	269797.Mbar_A2074	2.522e-55	203.0	COG4002@1|root,arCOG00854@2157|Archaea,2XVHH@28890|Euryarchaeota,2NBJX@224756|Methanomicrobia	224756|Methanomicrobia	S	methyltransferase activity	mtxX	-	-	-	-	-	-	-	-	-	-	-	PTA_PTB
HKD1_k127_4848817_0	1094980.Mpsy_0356	3.52e-196	619.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N9EC@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-3	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_4848817_2	269797.Mbar_A2016	9.844e-74	266.0	arCOG03256@1|root,arCOG03256@2157|Archaea,2Y6XR@28890|Euryarchaeota,2NAP3@224756|Methanomicrobia	224756|Methanomicrobia	S	S-layer protein	-	-	-	-	-	-	-	-	-	-	-	-	S-layer
HKD1_k127_4921136_1	593750.Metfor_1609	2.717e-43	162.0	arCOG03443@1|root,arCOG03443@2157|Archaea,2XYM1@28890|Euryarchaeota	28890|Euryarchaeota	S	RimK-like ATPgrasp N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RLAN
HKD1_k127_4921136_2	1094980.Mpsy_0550	9.717e-11	64.0	COG3039@1|root,arCOG06508@2157|Archaea	2157|Archaea	L	transposase activity	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_4921136_0	1094980.Mpsy_2614	4.616e-194	621.0	COG1331@1|root,arCOG02007@2157|Archaea,2XU5Q@28890|Euryarchaeota,2N91Y@224756|Methanomicrobia	224756|Methanomicrobia	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_492252_0	192952.MM_1582	1.801e-89	298.0	COG0655@1|root,arCOG02573@2157|Archaea,2XWPJ@28890|Euryarchaeota,2NAHI@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_492252_2	65071.PYU1_T008525	5.271e-44	171.0	2CXWS@1|root,2S0BR@2759|Eukaryota,1MCQC@121069|Pythiales	121069|Pythiales	S	Source PGD	-	-	-	-	-	-	-	-	-	-	-	-	AstE_AspA
HKD1_k127_492252_1	56780.SYN_02218	5.636e-76	259.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_4960185_0	593750.Metfor_0200	1.5e-137	443.0	COG1032@1|root,arCOG04984@2157|Archaea,2XUS3@28890|Euryarchaeota,2N97H@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD1_k127_4960185_1	456442.Mboo_1155	1.566e-91	307.0	arCOG06074@1|root,arCOG06074@2157|Archaea,2XXIH@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_496181_1	1121448.DGI_2662	2.608e-50	198.0	COG3852@1|root,COG4191@1|root,COG3852@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2M97J@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	PFAM ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HAMP,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,sCache_2
HKD1_k127_496181_0	368407.Memar_1422	1.807e-96	325.0	COG2897@1|root,arCOG02019@2157|Archaea,2Y76U@28890|Euryarchaeota,2NBE7@224756|Methanomicrobia	224756|Methanomicrobia	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.11,2.8.1.2	ko:K01011,ko:K21028	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106,R07461	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_5002503_5	269797.Mbar_A0736	5.574e-09	58.0	COG1145@1|root,arCOG01610@2157|Archaea,2Y1GK@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_5002503_2	269797.Mbar_A2624	2.578e-30	122.0	COG4831@1|root,arCOG05211@2157|Archaea,2Y3XM@28890|Euryarchaeota,2NAZ8@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_5002503_4	593750.Metfor_2793	3.686e-18	87.0	arCOG03597@1|root,arCOG03597@2157|Archaea,2Y07Y@28890|Euryarchaeota,2NBAH@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
HKD1_k127_5002503_0	304371.MCP_1733	1.069e-38	151.0	COG0655@1|root,COG1592@1|root,arCOG01097@2157|Archaea,arCOG02578@2157|Archaea	2157|Archaea	P	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red,Rubrerythrin
HKD1_k127_5002503_1	323259.Mhun_0629	2.828e-33	132.0	COG0655@1|root,arCOG02578@2157|Archaea	2157|Archaea	P	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_5002503_3	1089544.KB912942_gene1770	4.512e-22	98.0	COG3794@1|root,COG3794@2|Bacteria,2IQAI@201174|Actinobacteria,4EEXI@85010|Pseudonocardiales	201174|Actinobacteria	C	Copper binding proteins, plastocyanin/azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD1_k127_5008840_0	933262.AXAM01000025_gene3431	5.793e-38	162.0	COG1413@1|root,COG1413@2|Bacteria,1QCWA@1224|Proteobacteria,42M5W@68525|delta/epsilon subdivisions,2WM1Q@28221|Deltaproteobacteria,2MI9I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5008840_1	643867.Ftrac_1096	2.065e-05	57.0	2DCFR@1|root,2ZDYQ@2|Bacteria,4NPNX@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_5042615_1	1094980.Mpsy_0823	3.878e-33	131.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2NAE5@224756|Methanomicrobia	224756|Methanomicrobia	O	Peptidase family M48	-	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_5042615_2	351160.RCIX1863	6.306e-13	71.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,2N9VZ@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_5042615_0	877455.Metbo_0399	4.303e-49	184.0	arCOG03622@1|root,arCOG03622@2157|Archaea,2Y55W@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5048296_4	247490.KSU1_C1026	6.674e-43	166.0	COG0711@1|root,COG0711@2|Bacteria,2IZ3I@203682|Planctomycetes	203682|Planctomycetes	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_5048296_5	313624.NSP_4390	2.002e-33	130.0	COG0636@1|root,COG0636@2|Bacteria,1G7XV@1117|Cyanobacteria	1117|Cyanobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_5048296_2	1288826.MSNKSG1_04286	1.281e-80	274.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1S0SN@1236|Gammaproteobacteria,469DQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB1	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_5048296_7	1266925.JHVX01000002_gene857	2.278e-14	76.0	2E6XU@1|root,331H5@2|Bacteria,1N0RI@1224|Proteobacteria,2VUYX@28216|Betaproteobacteria,373NC@32003|Nitrosomonadales	28216|Betaproteobacteria	S	N-ATPase, AtpR subunit	-	-	-	-	-	-	-	-	-	-	-	-	AtpR
HKD1_k127_5048296_6	1123487.KB892848_gene751	1.715e-30	124.0	2CBNW@1|root,32RTR@2|Bacteria,1N7RB@1224|Proteobacteria,2VVDG@28216|Betaproteobacteria,2KZI7@206389|Rhodocyclales	206389|Rhodocyclales	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	-	-	-	-	-	-	-	-	-	ATPase_gene1
HKD1_k127_5048296_3	767817.Desgi_4159	2.503e-45	167.0	COG0355@1|root,COG0355@2|Bacteria,1VHIW@1239|Firmicutes,24TSB@186801|Clostridia	186801|Clostridia	C	ATP synthase, Delta/Epsilon chain, beta-sandwich domain	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
HKD1_k127_5048296_0	247490.KSU1_C1020	5.629e-210	662.0	COG0055@1|root,COG0055@2|Bacteria,2IYHU@203682|Planctomycetes	203682|Planctomycetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_5048296_1	456442.Mboo_1503	1.686e-85	287.0	COG0605@1|root,arCOG04147@2157|Archaea,2XUDD@28890|Euryarchaeota,2NAEN@224756|Methanomicrobia	224756|Methanomicrobia	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_5051951_0	868131.MSWAN_2374	7.555e-95	316.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,23NP7@183925|Methanobacteria	183925|Methanobacteria	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_5051951_1	304371.MCP_0085	1.878e-36	141.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,2NBJG@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5061643_0	269797.Mbar_A2866	2.966e-98	328.0	COG4022@1|root,arCOG04893@2157|Archaea,2XVN1@28890|Euryarchaeota,2N9I3@224756|Methanomicrobia	224756|Methanomicrobia	S	Methanogenesis marker protein 8	-	-	-	-	-	-	-	-	-	-	-	-	DUF2099
HKD1_k127_5061643_2	456442.Mboo_0783	1.363e-35	139.0	arCOG09489@1|root,arCOG09489@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5061643_1	269797.Mbar_A1959	4.163e-55	198.0	arCOG00526@1|root,arCOG00526@2157|Archaea,2Y3VB@28890|Euryarchaeota,2NAV4@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD1_k127_5116658_20	192952.MM_0674	1.102e-13	75.0	COG1382@1|root,arCOG01342@2157|Archaea,2XX88@28890|Euryarchaeota,2N9TP@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
HKD1_k127_5116658_23	694440.JOMF01000005_gene121	3.43e-06	53.0	COG2892@1|root,arCOG04414@2157|Archaea	2157|Archaea	S	protein conserved in archaea	pcc1	GO:0000408,GO:0002949,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:1901360	-	ko:K09741	-	-	-	-	ko00000,ko03016	-	-	-	Pcc1
HKD1_k127_5116658_18	1094980.Mpsy_2732	2.038e-20	90.0	COG1996@1|root,arCOG04341@2157|Archaea,2XZUD@28890|Euryarchaeota,2NA5N@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoP	-	2.7.7.6	ko:K03059	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	DNA_RNApol_7kD
HKD1_k127_5116658_14	304371.MCP_2625	1.621e-28	116.0	COG1997@1|root,arCOG04208@2157|Archaea,2XYWD@28890|Euryarchaeota,2N9ZP@224756|Methanomicrobia	224756|Methanomicrobia	J	binds to the 23S rRNA	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
HKD1_k127_5116658_7	351160.RCIX2125	1.069e-101	337.0	COG2123@1|root,arCOG01574@2157|Archaea,2XWTK@28890|Euryarchaeota,2N93P@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_5116658_6	351160.RCIX2124	4.816e-102	338.0	COG0689@1|root,arCOG01575@2157|Archaea,2XVHI@28890|Euryarchaeota,2N95P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_5116658_9	304371.MCP_2628	2.153e-82	279.0	COG1097@1|root,arCOG00678@2157|Archaea,2XWEN@28890|Euryarchaeota,2N9KQ@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,KH_6,S1
HKD1_k127_5116658_8	351160.RCIX2122	2.218e-99	328.0	COG1500@1|root,arCOG04187@2157|Archaea,2XTNH@28890|Euryarchaeota,2N9D8@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Shwachman-Bodian-Diamond syndrome	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
HKD1_k127_5116658_5	269797.Mbar_A2503	1.028e-111	365.0	COG0638@1|root,arCOG00971@2157|Archaea,2XUKA@28890|Euryarchaeota,2N98W@224756|Methanomicrobia	224756|Methanomicrobia	O	Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation	psmA	GO:0000502,GO:0005575,GO:0005622,GO:0005623,GO:0005839,GO:0019773,GO:0032991,GO:0044424,GO:0044464,GO:1902494,GO:1905368,GO:1905369	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
HKD1_k127_5116658_15	351160.RCIX2120	5.784e-26	113.0	COG1369@1|root,arCOG01365@2157|Archaea,2XX63@28890|Euryarchaeota,2NA1F@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp2	-	3.1.26.5	ko:K03537	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_Rpp14
HKD1_k127_5116658_13	304371.MCP_2634	1.211e-37	150.0	COG1603@1|root,arCOG00307@2157|Archaea,2XU7Q@28890|Euryarchaeota,2N9T6@224756|Methanomicrobia	224756|Methanomicrobia	J	Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends	rnp3	-	3.1.26.5	ko:K03539	ko03008,ko03013,map03008,map03013	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03016,ko03029	-	-	-	RNase_P_p30
HKD1_k127_5116658_16	1094980.Mpsy_2723	9.693e-24	107.0	COG1325@1|root,arCOG01042@2157|Archaea,2Y01Q@28890|Euryarchaeota,2NA08@224756|Methanomicrobia	224756|Methanomicrobia	J	RNA binding	-	-	-	ko:K07581	-	-	-	-	ko00000	-	-	-	RNA_binding
HKD1_k127_5116658_10	1041930.Mtc_0349	1.684e-77	263.0	COG1632@1|root,arCOG04209@2157|Archaea,2XTJJ@28890|Euryarchaeota,2N9HN@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL15 family	rpl15e	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
HKD1_k127_5116658_11	523845.AQXV01000055_gene92	2.635e-49	187.0	arCOG06693@1|root,arCOG06693@2157|Archaea,2Y20U@28890|Euryarchaeota	28890|Euryarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5116658_4	1158318.ATXC01000002_gene1643	6.687e-164	524.0	COG1260@1|root,COG1260@2|Bacteria,2G3U0@200783|Aquificae	200783|Aquificae	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth
HKD1_k127_5116658_3	1209989.TepiRe1_0739	9.512e-166	539.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,42FCI@68295|Thermoanaerobacterales	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD1_k127_5116658_24	626418.bglu_2g20550	3.329e-05	51.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2VGZQ@28216|Betaproteobacteria,1K1KS@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Histidine kinase	-	-	-	ko:K14978	ko02020,map02020	M00663	-	-	ko00000,ko00001,ko00002,ko01001,ko02022	-	-	-	HATPase_c,HisKA,Hpt,Response_reg
HKD1_k127_5116658_17	387631.Asulf_00796	1.334e-23	100.0	COG2835@1|root,arCOG04124@2157|Archaea,2XZRS@28890|Euryarchaeota,247DV@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0434 family	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
HKD1_k127_5116658_0	1094980.Mpsy_2605	3.588e-222	703.0	COG0504@1|root,arCOG00063@2157|Archaea,2XTR2@28890|Euryarchaeota,2N94B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD1_k127_5116658_19	1122134.KB893650_gene780	7.407e-14	75.0	COG4572@1|root,COG4572@2|Bacteria,1N93H@1224|Proteobacteria,1S94E@1236|Gammaproteobacteria,1XM05@135619|Oceanospirillales	135619|Oceanospirillales	S	ChaB	-	-	-	ko:K06197	-	-	-	-	ko00000	-	-	-	ChaB
HKD1_k127_5116658_2	192952.MM_0093	5.38e-171	550.0	COG1492@1|root,arCOG00105@2157|Archaea,2XT04@28890|Euryarchaeota,2N93Y@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_5116658_22	224325.AF_1352	1.481e-09	60.0	COG3335@1|root,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_32,HTH_33
HKD1_k127_5116658_21	1070774.J07HN4v3_00235	1.617e-12	70.0	COG3335@1|root,arCOG02130@2157|Archaea,2Y8IS@28890|Euryarchaeota,23UQJ@183963|Halobacteria	183963|Halobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32,HTH_33
HKD1_k127_5116658_1	269797.Mbar_A2775	6.948e-172	552.0	COG1964@1|root,arCOG00933@2157|Archaea,2XTMK@28890|Euryarchaeota,2N91G@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K06937	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_5116658_12	192952.MM_1466	5.032e-41	156.0	COG3677@1|root,arCOG02137@2157|Archaea	2157|Archaea	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Zn_Tnp_IS1595
HKD1_k127_5119136_0	693661.Arcve_1757	7.491e-228	727.0	COG1111@1|root,arCOG00872@2157|Archaea,2XTBV@28890|Euryarchaeota,245TM@183980|Archaeoglobi	183980|Archaeoglobi	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K10896	ko03460,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C
HKD1_k127_5119136_26	1094980.Mpsy_0033	6.681e-09	57.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_5119136_28	1123274.KB899412_gene1369	1.43e-05	51.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_5119136_22	192952.MM_1559	1.001e-18	94.0	arCOG02874@1|root,arCOG02874@2157|Archaea,2Y43V@28890|Euryarchaeota,2NB28@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5119136_11	760568.Desku_1027	1.888e-77	265.0	COG0491@1|root,COG0491@2|Bacteria,1UZUA@1239|Firmicutes,24CIA@186801|Clostridia,26369@186807|Peptococcaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_5119136_2	868131.MSWAN_0295	3.194e-165	527.0	COG1602@1|root,arCOG04269@2157|Archaea,2XTEQ@28890|Euryarchaeota,23NMK@183925|Methanobacteria	183925|Methanobacteria	S	Archaeal Nre, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Nre_C,Nre_N
HKD1_k127_5119136_7	192952.MM_1297	1.618e-93	317.0	COG0430@1|root,arCOG04125@2157|Archaea,2XT7I@28890|Euryarchaeota,2N9B3@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
HKD1_k127_5119136_23	1094980.Mpsy_2113	4.175e-17	84.0	COG1761@1|root,arCOG04111@2157|Archaea,2XYYQ@28890|Euryarchaeota,2NA0Z@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoL	-	2.7.7.6	ko:K03056	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_L_2
HKD1_k127_5119136_19	1041930.Mtc_1739	5.372e-45	169.0	COG1096@1|root,arCOG00676@2157|Archaea,2XYYA@28890|Euryarchaeota,2N9T0@224756|Methanomicrobia	224756|Methanomicrobia	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	ECR1_N,EXOSC1
HKD1_k127_5119136_17	192952.MM_1878	4.608e-54	196.0	COG2263@1|root,arCOG00910@2157|Archaea,2XU4P@28890|Euryarchaeota,2N9NN@224756|Methanomicrobia	224756|Methanomicrobia	Q	methyltransferase small	-	-	-	ko:K07579	-	-	-	-	ko00000	-	-	-	MTS,PrmA
HKD1_k127_5119136_25	1123376.AUIU01000003_gene1627	1.887e-10	74.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,3J14G@40117|Nitrospirae	40117|Nitrospirae	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12
HKD1_k127_5119136_4	192952.MM_1371	1.7e-125	409.0	COG0182@1|root,arCOG01123@2157|Archaea,2Y86P@28890|Euryarchaeota,2N95Z@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	-	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD1_k127_5119136_10	269797.Mbar_A3172	5.303e-78	267.0	COG0120@1|root,arCOG01122@2157|Archaea,2XTXI@28890|Euryarchaeota,2N9IQ@224756|Methanomicrobia	224756|Methanomicrobia	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD1_k127_5119136_1	192952.MM_1383	1.024e-211	670.0	COG0016@1|root,arCOG00411@2157|Archaea,2XUJD@28890|Euryarchaeota,2N9CX@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of O-phosphoserine (Sep) to tRNA(Cys)	sepS	-	6.1.1.27	ko:K07587	ko00970,map00970	M00360	R08576	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
HKD1_k127_5119136_18	351160.RRC419	1.773e-52	192.0	COG2178@1|root,arCOG04318@2157|Archaea,2XYD0@28890|Euryarchaeota,2N9Q9@224756|Methanomicrobia	224756|Methanomicrobia	J	RNA-binding protein of the translin family	-	-	-	ko:K07477	-	-	-	-	ko00000	-	-	-	Translin
HKD1_k127_5119136_8	269797.Mbar_A0973	1.269e-84	287.0	COG1082@1|root,arCOG01895@2157|Archaea,2XUTU@28890|Euryarchaeota,2N9NR@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_5119136_21	1041930.Mtc_0790	2.193e-22	103.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,2N9RC@224756|Methanomicrobia	224756|Methanomicrobia	H	adenyl ribonucleotide binding	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0975	AAA_17,RNA_binding
HKD1_k127_5119136_3	351160.RCIX567	2.116e-156	503.0	COG1503@1|root,arCOG01742@2157|Archaea,2XSV5@28890|Euryarchaeota,2N9BK@224756|Methanomicrobia	224756|Methanomicrobia	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
HKD1_k127_5119136_14	192952.MM_2379	1.218e-72	252.0	COG0005@1|root,arCOG01327@2157|Archaea,2XUJX@28890|Euryarchaeota,2NA1R@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_5119136_24	673862.BABL1_1000	1.048e-15	89.0	COG1520@1|root,COG3391@1|root,COG1520@2|Bacteria,COG3391@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
HKD1_k127_5119136_16	1094980.Mpsy_2662	1.639e-64	227.0	COG1890@1|root,arCOG04186@2157|Archaea,2XSX9@28890|Euryarchaeota,2N9KM@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eS1 family	rps3ae	-	-	ko:K02984	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S3Ae
HKD1_k127_5119136_5	1094980.Mpsy_1383	1.476e-121	397.0	COG1469@1|root,arCOG04301@2157|Archaea,2XT11@28890|Euryarchaeota,2N944@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin	mptA	-	3.5.4.39	ko:K17488	ko00790,map00790	-	R10348	RC02504,RC03131	ko00000,ko00001,ko01000	-	-	-	GCHY-1
HKD1_k127_5119136_15	1094980.Mpsy_1792	4.086e-66	231.0	COG1859@1|root,arCOG04063@2157|Archaea,2XWPC@28890|Euryarchaeota,2N9J7@224756|Methanomicrobia	224756|Methanomicrobia	J	Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase	kptA	-	-	ko:K07559	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PTS_2-RNA
HKD1_k127_5119136_20	1041930.Mtc_0475	3.746e-38	150.0	COG0020@1|root,arCOG01532@2157|Archaea,2XU1R@28890|Euryarchaeota,2N9SY@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Di-trans-poly-cis-decaprenylcistransferase	uppS-1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_5119136_12	1094980.Mpsy_0056	9.957e-75	266.0	COG1836@1|root,arCOG02245@2157|Archaea,2XTBR@28890|Euryarchaeota,2N936@224756|Methanomicrobia	224756|Methanomicrobia	S	Integral membrane protein DUF92	-	-	-	-	-	-	-	-	-	-	-	-	DUF92
HKD1_k127_5119136_13	1202768.JROF01000008_gene2796	3.619e-73	255.0	COG0169@1|root,arCOG01033@2157|Archaea,2XV7K@28890|Euryarchaeota,23SSE@183963|Halobacteria	183963|Halobacteria	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_5119136_6	192952.MM_1275	2.397e-101	338.0	COG0722@1|root,arCOG00245@2157|Archaea,2XU8C@28890|Euryarchaeota,2N9HG@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD1_k127_5119136_9	472759.Nhal_2482	2.102e-79	273.0	COG3823@1|root,COG3823@2|Bacteria,1R9YU@1224|Proteobacteria,1RZ5N@1236|Gammaproteobacteria,1WXPE@135613|Chromatiales	135613|Chromatiales	O	PFAM Glutamine cyclotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_cyclase_2
HKD1_k127_5131122_5	1094980.Mpsy_2777	1.328e-20	93.0	COG1901@1|root,arCOG01239@2157|Archaea,2XTSB@28890|Euryarchaeota,2N9P7@224756|Methanomicrobia	224756|Methanomicrobia	J	Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs	trmY	-	2.1.1.257	ko:K16317	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltrn_RNA_2
HKD1_k127_5131122_3	909663.KI867150_gene1751	2.421e-48	180.0	COG0637@1|root,COG0637@2|Bacteria,1QTT8@1224|Proteobacteria,42RX7@68525|delta/epsilon subdivisions,2WNPY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_5131122_2	1094980.Mpsy_0916	3.548e-61	217.0	COG0284@1|root,arCOG00081@2157|Archaea,2XU66@28890|Euryarchaeota,2N9J4@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0060	OMPdecase
HKD1_k127_5131122_1	1094980.Mpsy_2840	1.529e-171	544.0	COG1697@1|root,arCOG04143@2157|Archaea,2XTNQ@28890|Euryarchaeota,2N9CW@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
HKD1_k127_5131122_0	192952.MM_2417	1.889e-226	717.0	COG1389@1|root,arCOG01165@2157|Archaea,2XTZQ@28890|Euryarchaeota,2N9CP@224756|Methanomicrobia	224756|Methanomicrobia	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6B	-	5.99.1.3	ko:K03167	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	HATPase_c,Topo-VIb_trans
HKD1_k127_5131122_4	351160.RRC465	3.595e-24	103.0	COG1522@1|root,arCOG01117@2157|Archaea,2XZZ4@28890|Euryarchaeota,2N9YN@224756|Methanomicrobia	224756|Methanomicrobia	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_5146480_3	1094980.Mpsy_2891	1.484e-112	367.0	COG2069@1|root,arCOG01980@2157|Archaea,2XTXS@28890|Euryarchaeota,2N93F@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhD	-	2.1.1.245	ko:K00194	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0200	CdhD
HKD1_k127_5146480_0	1094980.Mpsy_2890	3.186e-183	584.0	COG1456@1|root,arCOG01979@2157|Archaea,2XUSG@28890|Euryarchaeota,2N9BD@224756|Methanomicrobia	224756|Methanomicrobia	C	Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing	cdhE	-	2.1.1.245	ko:K00197	ko00680,ko00720,ko01120,ko01200,map00680,map00720,map01120,map01200	M00357,M00377,M00422	R09096,R10219,R10243	RC00004,RC00113,RC02977	ko00000,ko00001,ko00002,ko01000	-	-	-	CdhD,FeS
HKD1_k127_5146480_16	269797.Mbar_A3460	4.392e-13	73.0	arCOG03394@1|root,arCOG03394@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5146480_8	192952.MM_2056	8.141e-51	187.0	COG2266@1|root,arCOG01871@2157|Archaea,2XZP4@28890|Euryarchaeota,2N9T9@224756|Methanomicrobia	224756|Methanomicrobia	M	MobA-like NTP transferase domain	cobY	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_5146480_10	1094980.Mpsy_3103	7.419e-48	181.0	COG0368@1|root,arCOG04338@2157|Archaea,2XU3T@28890|Euryarchaeota,2N9QS@224756|Methanomicrobia	224756|Methanomicrobia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD1_k127_5146480_7	192952.MM_2058	3.23e-55	198.0	COG1267@1|root,arCOG01869@2157|Archaea,2XZTX@28890|Euryarchaeota,2NA1N@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM Phosphatidylglycerophosphatase A	-	-	-	-	-	-	-	-	-	-	-	-	PgpA
HKD1_k127_5146480_14	877455.Metbo_0389	6.441e-23	101.0	COG4075@1|root,arCOG03424@2157|Archaea,2XYU3@28890|Euryarchaeota	28890|Euryarchaeota	S	Uncharacterized protein, homolog of nitrogen regulatory protein PII	-	-	-	-	-	-	-	-	-	-	-	-	Nit_Regul_Hom
HKD1_k127_5146480_15	86416.Clopa_4256	1.208e-20	93.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,36KQ6@31979|Clostridiaceae	186801|Clostridia	O	PFAM nitrogen-fixing NifU	-	-	-	-	-	-	-	-	-	-	-	-	NifU
HKD1_k127_5146480_13	192952.MM_2383	7.467e-24	102.0	COG1958@1|root,arCOG00998@2157|Archaea,2Y0FB@28890|Euryarchaeota,2NA05@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM Like-Sm ribonucleoprotein, core	-	-	-	-	-	-	-	-	-	-	-	-	LSM
HKD1_k127_5146480_12	351160.RRC100	3.352e-24	106.0	COG1522@1|root,arCOG04153@2157|Archaea,2XX2W@28890|Euryarchaeota,2N9ZN@224756|Methanomicrobia	224756|Methanomicrobia	K	B-block binding subunit of TFIIIC	-	-	-	-	-	-	-	-	-	-	-	-	B-block_TFIIIC
HKD1_k127_5146480_11	1094980.Mpsy_2006	1.644e-43	161.0	COG0023@1|root,arCOG04223@2157|Archaea,2XXW5@28890|Euryarchaeota,2N9W4@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
HKD1_k127_5146480_1	192952.MM_0375	1.108e-134	458.0	arCOG02907@1|root,arCOG02907@2157|Archaea,2XVFW@28890|Euryarchaeota,2NAD7@224756|Methanomicrobia	224756|Methanomicrobia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD1_k127_5146480_6	192952.MM_0374	3.107e-96	337.0	arCOG02905@1|root,arCOG02905@2157|Archaea,2XU82@28890|Euryarchaeota,2NANS@224756|Methanomicrobia	224756|Methanomicrobia	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA
HKD1_k127_5146480_9	269797.Mbar_A2921	2.327e-50	183.0	COG1145@1|root,arCOG00292@2157|Archaea,2XXJH@28890|Euryarchaeota,2NAU1@224756|Methanomicrobia	224756|Methanomicrobia	C	Putative Fe-S cluster	-	-	-	ko:K11260	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	FeS,Fer4
HKD1_k127_5146480_2	1094980.Mpsy_2957	1.947e-120	398.0	COG1029@1|root,arCOG01498@2157|Archaea,2XTYT@28890|Euryarchaeota,2NA77@224756|Methanomicrobia	224756|Methanomicrobia	C	Formylmethanofuran dehydrogenase, subunit B	-	-	1.2.7.12	ko:K00201	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_5146480_4	1041930.Mtc_2298	2.587e-112	369.0	COG0448@1|root,arCOG00912@2157|Archaea,2XTI4@28890|Euryarchaeota,2N975@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the ATCase OTCase family	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_5146480_5	1094980.Mpsy_1834	4.53e-98	330.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_5182309_0	593750.Metfor_0200	1.94e-258	808.0	COG1032@1|root,arCOG04984@2157|Archaea,2XUS3@28890|Euryarchaeota,2N97H@224756|Methanomicrobia	224756|Methanomicrobia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD1_k127_5182309_2	456442.Mboo_1155	2.586e-107	356.0	arCOG06074@1|root,arCOG06074@2157|Archaea,2XXIH@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5182309_3	273068.TTE2487	9.005e-89	306.0	COG0588@1|root,COG0588@2|Bacteria,1TQFP@1239|Firmicutes,248XG@186801|Clostridia,42FWV@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD1_k127_5182309_1	192952.MM_0714	4.634e-137	441.0	COG1830@1|root,arCOG04044@2157|Archaea,2XSY2@28890|Euryarchaeota,2N9FM@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM deoxyribose-phosphate aldolase phospho-2-dehydro-3-deoxyheptonate aldolase	-	-	2.2.1.11,4.1.2.13	ko:K16305	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R10049,R10050	RC00438,RC00439,RC02301,RC03034	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD1_k127_5182309_4	83406.HDN1F_20130	6.716e-41	163.0	COG2730@1|root,COG2730@2|Bacteria,1R5YR@1224|Proteobacteria,1SIZY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.123	ko:K05991	-	-	-	-	ko00000,ko01000	-	GH5	-	Cellulase
HKD1_k127_5223082_5	444157.Tneu_1782	8.058e-28	117.0	COG0294@1|root,arCOG01978@2157|Archaea,2XRYD@28889|Crenarchaeota	28889|Crenarchaeota	H	PFAM dihydropteroate synthase, DHPS	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_5223082_4	880072.Desac_1907	1.754e-55	205.0	COG1511@1|root,COG1511@2|Bacteria	2|Bacteria	Q	domain protein	-	-	-	ko:K01992,ko:K06994	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3,MMPL
HKD1_k127_5223082_2	880072.Desac_1908	5.587e-70	249.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,42S93@68525|delta/epsilon subdivisions,2X5GZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5223082_6	192952.MM_1551	5.67e-09	67.0	COG1361@1|root,arCOG02086@2157|Archaea,2Y7NE@28890|Euryarchaeota,2NA14@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5223082_3	324925.Ppha_0207	6.64e-67	236.0	COG1108@1|root,COG1108@2|Bacteria,1FEN1@1090|Chlorobi	1090|Chlorobi	P	ABC-3 protein	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD1_k127_5223082_1	1094980.Mpsy_2230	4.346e-80	275.0	COG1121@1|root,arCOG00201@2157|Archaea,2XTEU@28890|Euryarchaeota,2N9G8@224756|Methanomicrobia	224756|Methanomicrobia	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD1_k127_5223082_0	439481.Aboo_0405	2.506e-263	822.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,3F39E@33867|unclassified Euryarchaeota	28890|Euryarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_5223378_0	1227497.C491_17489	2.809e-18	87.0	arCOG11305@1|root,arCOG11305@2157|Archaea,2Y4GX@28890|Euryarchaeota,2400B@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5223378_2	1279009.ADICEAN_03497	5.099e-07	54.0	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5223378_1	1007103.AFHW01000140_gene3964	4.014e-16	85.0	COG0834@1|root,COG3852@1|root,COG0834@2|Bacteria,COG3852@2|Bacteria,1TSVK@1239|Firmicutes,4HFAR@91061|Bacilli,26VNI@186822|Paenibacillaceae	91061|Bacilli	T	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	HATPase_c,HisKA,PAS_9,SBP_bac_3
HKD1_k127_5235945_3	69014.TK2151	3.837e-23	103.0	COG1356@1|root,arCOG04554@2157|Archaea,2XXGH@28890|Euryarchaeota,243ZZ@183968|Thermococci	183968|Thermococci	K	Transcriptional regulator	tfx	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0097159,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K09714	-	-	-	-	ko00000	-	-	-	Sigma70_r4,TFX_C
HKD1_k127_5235945_2	1220534.B655_2238	1.246e-69	247.0	COG3839@1|root,arCOG00175@2157|Archaea,2Y7MB@28890|Euryarchaeota,23PKR@183925|Methanobacteria	183925|Methanobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HKD1_k127_5235945_1	1220534.B655_2239	1.428e-73	254.0	COG4662@1|root,arCOG00166@2157|Archaea,2XTDY@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD1_k127_5235945_0	368407.Memar_1892	2.243e-100	337.0	COG2998@1|root,arCOG00229@2157|Archaea,2XUR9@28890|Euryarchaeota,2N9NW@224756|Methanomicrobia	224756|Methanomicrobia	H	PBP superfamily domain	-	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_5237561_1	456442.Mboo_2248	2.176e-131	426.0	COG2100@1|root,arCOG00951@2157|Archaea,2XU1G@28890|Euryarchaeota,2NAIJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3, MiaB family, Radical SAM	-	-	-	ko:K06935	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_5237561_0	317936.Nos7107_4316	9.56e-149	482.0	COG1253@1|root,COG1253@2|Bacteria,1G16U@1117|Cyanobacteria,1HISP@1161|Nostocales	1117|Cyanobacteria	S	PFAM CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_5237561_2	192952.MM_3271	9.001e-31	123.0	COG0695@1|root,arCOG02606@2157|Archaea,2Y0MA@28890|Euryarchaeota,2NB72@224756|Methanomicrobia	224756|Methanomicrobia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_52482_2	387631.Asulf_00579	2.818e-47	176.0	COG2119@1|root,arCOG03458@2157|Archaea,2XYST@28890|Euryarchaeota,247C2@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_52482_4	272562.CA_C0546	0.0002615	48.0	2E61F@1|root,330QP@2|Bacteria,1VJWC@1239|Firmicutes,24V6X@186801|Clostridia,36PU4@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF4064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4064
HKD1_k127_52482_3	1229909.NSED_03170	4.311e-16	84.0	arCOG08231@1|root,arCOG08231@2157|Archaea,41T6Q@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Lamin Tail Domain	-	-	-	-	-	-	-	-	-	-	-	-	LTD
HKD1_k127_52482_0	192952.MM_2876	1.561e-98	332.0	COG0389@1|root,arCOG04582@2157|Archaea,2XTZZ@28890|Euryarchaeota,2NAE4@224756|Methanomicrobia	224756|Methanomicrobia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_52482_1	909663.KI867150_gene2448	7.136e-73	256.0	COG0631@1|root,COG0631@2|Bacteria	2|Bacteria	T	protein serine/threonine phosphatase activity	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD1_k127_5250747_0	1041930.Mtc_0221	8.982e-49	181.0	COG1411@1|root,arCOG00616@2157|Archaea,2XYJ0@28890|Euryarchaeota,2N9PP@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the HisA HisF family	-	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_5250747_2	357804.Ping_1818	0.0001275	51.0	28Y1X@1|root,2ZJXH@2|Bacteria,1R3P3@1224|Proteobacteria	1224|Proteobacteria	S	YEATS family	-	-	-	-	-	-	-	-	-	-	-	-	YEATS
HKD1_k127_5250747_1	402777.KB235904_gene2780	1.49e-07	59.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_5253661_2	304371.MCP_2003	1.861e-08	60.0	COG1575@1|root,arCOG00480@2157|Archaea	2157|Archaea	H	Belongs to the MenA family. Type 1 subfamily	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_5253661_0	521011.Mpal_2113	5.395e-202	652.0	COG0834@1|root,COG1301@1|root,arCOG01799@2157|Archaea,arCOG04335@2157|Archaea	2157|Archaea	C	COG1301 Na H -dicarboxylate symporters	gltP	GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039	-	ko:K02030,ko:K07862	-	M00236	-	-	ko00000,ko00002,ko02000	2.A.23.4,3.A.1.3	-	-	SBP_bac_3,SDF
HKD1_k127_5253661_1	138119.DSY0787	5.599e-111	374.0	COG1488@1|root,COG1488@2|Bacteria,1TPDW@1239|Firmicutes,247NY@186801|Clostridia,261EM@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase,QRPTase_C,QRPTase_N
HKD1_k127_5260745_0	269482.Bcep1808_5440	5.945e-120	393.0	COG0784@1|root,COG1982@1|root,COG0784@2|Bacteria,COG1982@2|Bacteria,1MWK4@1224|Proteobacteria,2VIJQ@28216|Betaproteobacteria,1K2VN@119060|Burkholderiaceae	28216|Betaproteobacteria	E	PFAM Orn Lys Arg decarboxylase major region	adiA	-	4.1.1.18,4.1.1.19	ko:K01582,ko:K01584	ko00310,ko00330,ko00960,ko01100,ko01110,map00310,map00330,map00960,map01100,map01110	M00133	R00462,R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C,OKR_DC_1_N
HKD1_k127_5260745_1	192952.MM_0574	6.456e-50	183.0	COG0394@1|root,arCOG04425@2157|Archaea,2XZ4R@28890|Euryarchaeota,2N9TH@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_5263318_0	269797.Mbar_A2871	1.122e-40	151.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5263318_1	1094980.Mpsy_0339	9.558e-13	73.0	COG1226@1|root,arCOG01958@2157|Archaea,2Y1ZP@28890|Euryarchaeota,2NA44@224756|Methanomicrobia	224756|Methanomicrobia	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_5275882_2	1220534.B655_1669	1.702e-29	126.0	COG1575@1|root,arCOG00480@2157|Archaea,2XXM6@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM UbiA prenyltransferase	-	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_5275882_3	1227487.C474_13609	1.617e-27	121.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota	28890|Euryarchaeota	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
HKD1_k127_5275882_5	41431.PCC8801_2219	2.971e-08	55.0	COG1451@1|root,COG1451@2|Bacteria,1G7NU@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function DUF45	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD1_k127_5275882_4	644281.MFS40622_0532	6.209e-16	81.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota	28890|Euryarchaeota	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD1_k127_5275882_0	1094980.Mpsy_0575	2.733e-211	663.0	COG1061@1|root,arCOG00874@2157|Archaea,2XTYQ@28890|Euryarchaeota,2N95D@224756|Methanomicrobia	224756|Methanomicrobia	L	helicase superfamily c-terminal domain	rad25	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
HKD1_k127_5275882_1	1094980.Mpsy_0576	5.28e-183	585.0	COG3372@1|root,arCOG04356@2157|Archaea,2XSTX@28890|Euryarchaeota,2N95G@224756|Methanomicrobia	224756|Methanomicrobia	L	Protein of unknown function (DUF790)	-	-	-	ko:K09744	-	-	-	-	ko00000	-	-	-	DUF790
HKD1_k127_5281403_0	665956.HMPREF1032_00546	7.798e-49	177.0	COG4821@1|root,COG4821@2|Bacteria,1TQS7@1239|Firmicutes,24C1W@186801|Clostridia	186801|Clostridia	S	protein containing SIS (Sugar ISomerase) phosphosugar binding domain	-	-	-	-	-	-	-	-	-	-	-	-	SIS_2
HKD1_k127_5281403_1	260799.BAS2970	2.394e-30	130.0	COG1670@1|root,COG1670@2|Bacteria,1UZR2@1239|Firmicutes,4HC5N@91061|Bacilli,1ZGB1@1386|Bacillus	91061|Bacilli	J	GNAT acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	GNAT_acetyltran
HKD1_k127_5307220_0	530564.Psta_4769	4.208e-149	484.0	COG1506@1|root,COG1506@2|Bacteria,2IYBE@203682|Planctomycetes	203682|Planctomycetes	EU	Peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD1_k127_5314282_0	1041930.Mtc_0274	3.494e-127	413.0	COG1257@1|root,arCOG04260@2157|Archaea,2XTV9@28890|Euryarchaeota	28890|Euryarchaeota	I	Belongs to the HMG-CoA reductase family	hmgA-1	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
HKD1_k127_5314282_1	304371.MCP_1674	1.133e-92	311.0	COG0077@1|root,arCOG00255@2157|Archaea,2XTAI@28890|Euryarchaeota,2N9DQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Prephenate dehydratase	pheA	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
HKD1_k127_5314282_3	1237149.C900_04128	2.421e-15	90.0	COG2911@1|root,COG3325@1|root,COG3979@1|root,COG5295@1|root,COG2911@2|Bacteria,COG3325@2|Bacteria,COG3979@2|Bacteria,COG5295@2|Bacteria,4NGAZ@976|Bacteroidetes,47JXX@768503|Cytophagia	976|Bacteroidetes	G	Glyco_18	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Glyco_hydro_18
HKD1_k127_5314282_2	1094980.Mpsy_1384	4.356e-29	118.0	arCOG04743@1|root,arCOG04743@2157|Archaea,2XXSX@28890|Euryarchaeota,2NA4F@224756|Methanomicrobia	224756|Methanomicrobia	S	Non-histone chromosomal protein MC1	-	-	-	-	-	-	-	-	-	-	-	-	MC1
HKD1_k127_5338353_1	1094980.Mpsy_1303	2.085e-14	85.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_5338353_2	794903.OPIT5_27555	6.396e-13	81.0	COG3118@1|root,COG3118@2|Bacteria,46VWK@74201|Verrucomicrobia,3K8B4@414999|Opitutae	414999|Opitutae	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_5338353_0	56110.Oscil6304_1021	4.871e-84	295.0	COG1404@1|root,COG4935@1|root,COG1404@2|Bacteria,COG4935@2|Bacteria,1G04W@1117|Cyanobacteria,1H940@1150|Oscillatoriales	1117|Cyanobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8,SLH
HKD1_k127_5345100_3	410358.Mlab_0690	6.714e-11	64.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_5345100_4	103733.JNYO01000005_gene8605	1.269e-05	52.0	2C54Q@1|root,3498C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5345100_0	986075.CathTA2_0544	1.007e-45	169.0	COG1479@1|root,COG3472@1|root,COG1479@2|Bacteria,COG3472@2|Bacteria,1TQ81@1239|Firmicutes,4HCVH@91061|Bacilli	91061|Bacilli	S	Protein of unknown function DUF262	-	-	-	-	-	-	-	-	-	-	-	-	DUF1524,DUF262
HKD1_k127_5345100_2	313628.LNTAR_15162	2.32e-18	88.0	COG3741@1|root,COG3741@2|Bacteria	2|Bacteria	E	N-formylglutamate amidohydrolase	hutG	-	3.5.3.8	ko:K01479	ko00340,ko01100,map00340,map01100	M00045	R02285	RC00221,RC00681	ko00000,ko00001,ko00002,ko01000	-	-	-	FGase
HKD1_k127_5345100_1	1463926.JOCA01000023_gene6339	1.571e-32	132.0	COG3741@1|root,COG3741@2|Bacteria,2GSDI@201174|Actinobacteria	201174|Actinobacteria	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HKD1_k127_5359180_2	697284.ERIC2_c04100	7.168e-06	48.0	COG3415@1|root,COG3415@2|Bacteria,1U1K0@1239|Firmicutes,4IB26@91061|Bacilli,273K7@186822|Paenibacillaceae	91061|Bacilli	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5359180_1	1463881.KL591028_gene467	4.018e-23	102.0	COG3415@1|root,COG3415@2|Bacteria,2I2W7@201174|Actinobacteria	201174|Actinobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
HKD1_k127_5359180_0	562970.Btus_2106	2.318e-50	183.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1U2YN@1239|Firmicutes,4HX7V@91061|Bacilli,27A4T@186823|Alicyclobacillaceae	91061|Bacilli	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_5368307_0	56780.SYN_02218	7.038e-285	889.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,42M8F@68525|delta/epsilon subdivisions,2WIU0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_5376441_2	593750.Metfor_1900	6.132e-08	53.0	COG0840@1|root,arCOG03007@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_5376441_1	439235.Dalk_0980	4.15e-11	64.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,42NA7@68525|delta/epsilon subdivisions,2WIN5@28221|Deltaproteobacteria,2MJ30@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD1_k127_5376441_0	192952.MM_2866	1.052e-56	202.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5398271_19	439235.Dalk_0266	9.839e-06	48.0	COG1675@1|root,COG1675@2|Bacteria,1MZ5R@1224|Proteobacteria,42WDA@68525|delta/epsilon subdivisions,2WS3H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	transcription initiation from RNA polymerase II promoter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5398271_8	269797.Mbar_A0877	3.17e-42	160.0	COG1051@1|root,arCOG01075@2157|Archaea,2XXS4@28890|Euryarchaeota,2N9US@224756|Methanomicrobia	224756|Methanomicrobia	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_5398271_7	304371.MCP_0670	1.81e-43	166.0	COG2054@1|root,arCOG00859@2157|Archaea,2XVEI@28890|Euryarchaeota,2N9QG@224756|Methanomicrobia	224756|Methanomicrobia	S	aspartate glutamate uridylate kinase	-	-	2.7.4.31	ko:K07144	ko00680,map00680	-	R11039	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_5398271_18	1041930.Mtc_2493	1.426e-16	81.0	COG2888@1|root,arCOG01989@2157|Archaea,2Y736@28890|Euryarchaeota,2NBEG@224756|Methanomicrobia	224756|Methanomicrobia	J	Domain of unknown function (DUF1610)	-	-	-	ko:K07580	-	-	-	-	ko00000	-	-	-	DUF1610
HKD1_k127_5398271_16	224719.Abm4_1460	3.166e-20	92.0	COG2092@1|root,arCOG01988@2157|Archaea,2XYNW@28890|Euryarchaeota	28890|Euryarchaeota	J	Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA	ef1b	-	-	ko:K03232	-	-	-	-	ko00000,ko03012	-	-	-	EF1_GNE
HKD1_k127_5398271_15	192952.MM_2792	1.412e-26	113.0	COG0314@1|root,arCOG00533@2157|Archaea,2XVFP@28890|Euryarchaeota,2N9H4@224756|Methanomicrobia	224756|Methanomicrobia	H	MoaE protein	mobB	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,MobB
HKD1_k127_5398271_11	44251.PDUR_23770	7.84e-41	167.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,4HB39@91061|Bacilli,2750F@186822|Paenibacillaceae	91061|Bacilli	E	Peptidase dimerisation domain	dapE_3	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_5398271_0	1216932.CM240_0991	1.012e-177	569.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,36EXB@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD1_k127_5398271_3	572546.Arcpr_0032	8.078e-65	228.0	COG2518@1|root,arCOG00976@2157|Archaea,2XTRM@28890|Euryarchaeota,245QI@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_5398271_4	351160.LRC18	1.24e-56	227.0	COG1404@1|root,arCOG00702@2157|Archaea,2XTGN@28890|Euryarchaeota,2N9WH@224756|Methanomicrobia	224756|Methanomicrobia	O	Subtilase family	-	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
HKD1_k127_5398271_6	1094980.Mpsy_2329	3.035e-51	191.0	COG4083@1|root,arCOG04471@2157|Archaea,2XTQZ@28890|Euryarchaeota,2N9VN@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Transmembrane exosortase (Exosortase_EpsH)	-	-	-	-	-	-	-	-	-	-	-	-	Exosortase_EpsH
HKD1_k127_5398271_10	289376.THEYE_A0652	6.429e-42	161.0	COG0688@1|root,COG0688@2|Bacteria,3J0KD@40117|Nitrospirae	40117|Nitrospirae	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD1_k127_5398271_13	192952.MM_1403	2.676e-31	131.0	COG1183@1|root,arCOG00671@2157|Archaea,2XT0G@28890|Euryarchaeota,2NAYG@224756|Methanomicrobia	224756|Methanomicrobia	I	CDP-alcohol phosphatidyltransferase	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0874	CDP-OH_P_transf
HKD1_k127_5398271_14	269797.Mbar_A0873	8.758e-30	121.0	COG2098@1|root,arCOG04705@2157|Archaea,2XY43@28890|Euryarchaeota,2N9TR@224756|Methanomicrobia	224756|Methanomicrobia	S	Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD)	mptD	-	4.1.2.25	ko:K09739	ko00790,map00790	-	R03504	RC00721,RC00943	ko00000,ko00001,ko01000	-	-	-	DHNA
HKD1_k127_5398271_1	269797.Mbar_A1178	3.699e-137	441.0	COG0519@1|root,arCOG00085@2157|Archaea,2XT82@28890|Euryarchaeota,2N92B@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAB	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	iAF692.Mbar_A1178	GMP_synt_C,NAD_synthase
HKD1_k127_5398271_2	1236689.MMALV_12580	5.592e-129	421.0	COG1163@1|root,arCOG00358@2157|Archaea,2XTYK@28890|Euryarchaeota,3F2I6@33867|unclassified Euryarchaeota	28890|Euryarchaeota	S	C-terminal region of MMR_HSR1 domain	drg	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,MMR_HSR1_Xtn,TGS
HKD1_k127_5398271_17	1094980.Mpsy_2155	4.769e-20	92.0	COG1873@1|root,arCOG02155@2157|Archaea,2XZ54@28890|Euryarchaeota,2N9Y7@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_5398271_5	1041930.Mtc_0578	1.423e-56	205.0	COG4021@1|root,arCOG03218@2157|Archaea,2XWU9@28890|Euryarchaeota,2N9I7@224756|Methanomicrobia	224756|Methanomicrobia	J	tRNAHis guanylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thg1,Thg1C
HKD1_k127_5398271_12	351160.RCIX403	2.313e-33	137.0	COG0727@1|root,arCOG02579@2157|Archaea,2XTK2@28890|Euryarchaeota,2N9XG@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_5398271_9	1041930.Mtc_0752	4.414e-42	156.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,2N9KA@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_5413239_0	1094980.Mpsy_2449	9.267e-110	365.0	COG1131@1|root,arCOG00196@2157|Archaea,2Y7M5@28890|Euryarchaeota,2NBN9@224756|Methanomicrobia	28890|Euryarchaeota	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_5413239_1	797299.HALLA_03070	1.215e-79	273.0	COG0842@1|root,arCOG01467@2157|Archaea,2XT3B@28890|Euryarchaeota,23UKT@183963|Halobacteria	183963|Halobacteria	V	COG0842 ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_5416201_0	326427.Cagg_1111	6.102e-17	83.0	COG2423@1|root,COG2423@2|Bacteria,2G6BQ@200795|Chloroflexi,375XV@32061|Chloroflexia	32061|Chloroflexia	E	PFAM ornithine cyclodeaminase mu-crystallin	-	-	4.3.1.12	ko:K01750	ko00330,ko01110,ko01130,ko01230,map00330,map01110,map01130,map01230	-	R00671	RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HKD1_k127_5419905_2	269797.Mbar_A2624	4.545e-13	73.0	COG4831@1|root,arCOG05211@2157|Archaea,2Y3XM@28890|Euryarchaeota,2NAZ8@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_5419905_0	56110.Oscil6304_1320	3.918e-31	130.0	COG0454@1|root,COG0456@2|Bacteria,1G7YM@1117|Cyanobacteria,1HD59@1150|Oscillatoriales	1117|Cyanobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5419905_1	1122132.AQYH01000010_gene4316	1.962e-15	83.0	arCOG05203@1|root,31A0K@2|Bacteria,1RHZR@1224|Proteobacteria,2U9JR@28211|Alphaproteobacteria,4BHAP@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5420184_1	269797.Mbar_A0865	2.012e-59	209.0	COG4081@1|root,arCOG04845@2157|Archaea,2XXFT@28890|Euryarchaeota,2NAY0@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF1890)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1890
HKD1_k127_5420184_2	374847.Kcr_0946	1.629e-45	173.0	COG0778@1|root,arCOG00288@2157|Archaea	2157|Archaea	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_5420184_0	1220534.B655_0924	7.662e-76	263.0	COG0803@1|root,arCOG01005@2157|Archaea,2XV9U@28890|Euryarchaeota	28890|Euryarchaeota	P	ABC-type metal ion transport system periplasmic component surface adhesin	znuA1	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_5420184_4	1514668.JOOA01000002_gene1447	7.242e-16	87.0	COG0330@1|root,COG0330@2|Bacteria,1UZJK@1239|Firmicutes,24IK1@186801|Clostridia,3WHEQ@541000|Ruminococcaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_5420184_3	33035.JPJF01000004_gene1994	5.787e-18	86.0	COG3708@1|root,COG3708@2|Bacteria,1VFMZ@1239|Firmicutes,24RKD@186801|Clostridia	186801|Clostridia	K	Putative zinc ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Cass2,Zn_ribbon_2
HKD1_k127_5428939_3	1192034.CAP_8574	8.089e-50	179.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2YWG3@29|Myxococcales	28221|Deltaproteobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
HKD1_k127_5428939_4	525897.Dbac_1798	8.871e-30	128.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,42VTP@68525|delta/epsilon subdivisions,2X5B0@28221|Deltaproteobacteria,2MGNS@213115|Desulfovibrionales	28221|Deltaproteobacteria	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HKD1_k127_5428939_1	387631.Asulf_00798	7.448e-150	483.0	COG0343@1|root,arCOG00989@2157|Archaea,2XWJH@28890|Euryarchaeota,246WR@183980|Archaeoglobi	183980|Archaeoglobi	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	-	-	2.4.2.29,2.4.2.48	ko:K00773,ko:K18779	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_5428939_2	479434.Sthe_2774	1.092e-138	461.0	28HJF@1|root,2Z7UK@2|Bacteria,2G862@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5428939_0	351160.RCIX2337	2.048e-180	574.0	COG0541@1|root,arCOG01228@2157|Archaea,2XTWX@28890|Euryarchaeota,2N99J@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	srp54	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_5428939_5	192952.MM_2671	2.698e-25	119.0	COG0628@1|root,arCOG02642@2157|Archaea,2XT00@28890|Euryarchaeota	28890|Euryarchaeota	S	Permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_5430279_7	456442.Mboo_0658	2.658e-43	163.0	COG0072@1|root,arCOG00412@2157|Archaea,2XTD5@28890|Euryarchaeota,2N943@224756|Methanomicrobia	224756|Methanomicrobia	J	phenylalanyl-tRNA synthetase beta subunit	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,tRNA-synt_2d
HKD1_k127_5430279_3	269797.Mbar_A0980	8.359e-108	356.0	COG2037@1|root,arCOG02695@2157|Archaea,2XT8E@28890|Euryarchaeota,2N97E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the reversible transfer of a formyl group from formylmethanofuran (formyl-MFR) to tetrahydromethanopterin (H(4)MPT) so as to produce 5-formyl tetrahydromethanopterin (5- formyl-H(4)MPT) and methanofuran (MFR)	ftr	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.101	ko:K00672	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03390	RC00197,RC00870,RC02881	ko00000,ko00001,ko00002,ko01000	-	-	-	FTR,FTR_C
HKD1_k127_5430279_6	351160.RCIX491	2.563e-50	185.0	COG3363@1|root,arCOG04727@2157|Archaea,2XTEV@28890|Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP	purO	-	3.5.4.10	ko:K11176	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R01127	RC00456	ko00000,ko00001,ko00002,ko01000	-	-	-	IMP_cyclohyd
HKD1_k127_5430279_2	593750.Metfor_2541	5.566e-111	365.0	COG1013@1|root,arCOG01601@2157|Archaea,2XT3E@28890|Euryarchaeota,2N989@224756|Methanomicrobia	224756|Methanomicrobia	C	thiamine pyrophosphate enzyme domain protein TPP-binding	porB-1	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_5430279_1	192952.MM_1340	3.009e-156	501.0	COG0674@1|root,arCOG01608@2157|Archaea,2XTB0@28890|Euryarchaeota,2N98Z@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate flavodoxin ferredoxin oxidoreductase domain protein	porA-1	-	1.2.7.1	ko:K00169	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_5430279_8	1121440.AUMA01000003_gene3016	1.536e-27	113.0	COG1144@1|root,COG1144@2|Bacteria,1N5VK@1224|Proteobacteria,43B7A@68525|delta/epsilon subdivisions,2X6KR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_5430279_4	304371.MCP_2611	1.431e-68	238.0	COG1014@1|root,arCOG01603@2157|Archaea,2XVFR@28890|Euryarchaeota,2N9J1@224756|Methanomicrobia	224756|Methanomicrobia	C	TIGRFAM pyruvate ketoisovalerate oxidoreductase, gamma subunit	porC-1	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_5430279_9	269797.Mbar_A0736	3.972e-14	74.0	COG1145@1|root,arCOG01610@2157|Archaea,2Y1GK@28890|Euryarchaeota	28890|Euryarchaeota	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_5430279_0	1094980.Mpsy_2210	0.0	1120.0	COG1328@1|root,arCOG04889@2157|Archaea,2XT2S@28890|Euryarchaeota,2N92H@224756|Methanomicrobia	224756|Methanomicrobia	F	TIGRFAM anaerobic ribonucleoside-triphosphate reductase	nrdD	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,NRDD
HKD1_k127_5430279_5	192952.MM_0284	4.396e-58	210.0	COG0388@1|root,arCOG00062@2157|Archaea,2XT6R@28890|Euryarchaeota,2NA3A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HKD1_k127_5430279_10	1094980.Mpsy_1230	1.301e-06	51.0	COG1467@1|root,arCOG04110@2157|Archaea,2XUZF@28890|Euryarchaeota,2N95F@224756|Methanomicrobia	224756|Methanomicrobia	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
HKD1_k127_5447925_1	269797.Mbar_A1634	7.969e-93	316.0	COG1736@1|root,arCOG04112@2157|Archaea,2XSY5@28890|Euryarchaeota,2N9AT@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM Diphthamide synthesis DPH2 protein	dph2	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
HKD1_k127_5447925_0	589924.Ferp_1312	5.941e-115	379.0	COG0258@1|root,arCOG04050@2157|Archaea,2XTJD@28890|Euryarchaeota,246UR@183980|Archaeoglobi	183980|Archaeoglobi	L	Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double- stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into	fen	-	-	ko:K04799	ko03030,ko03410,ko03450,map03030,map03410,map03450	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400,ko04147	-	-	-	XPG_I,XPG_N
HKD1_k127_5447925_4	192952.MM_2016	8.379e-11	67.0	COG0316@1|root,arCOG04560@2157|Archaea,2XXWU@28890|Euryarchaeota,2NA1P@224756|Methanomicrobia	224756|Methanomicrobia	O	Iron-sulphur cluster biosynthesis	-	-	-	ko:K15724	-	-	-	-	ko00000	-	-	-	Fe-S_biosyn
HKD1_k127_5447925_3	1056495.Calag_0061	2.097e-22	102.0	COG0537@1|root,arCOG00419@2157|Archaea	2157|Archaea	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	2.5.1.3,2.7.7.53	ko:K02503,ko:K19710,ko:K21220	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00126,R01618,R03223,R10712	RC00002,RC00224,RC02753,RC02795,RC03255,RC03397	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT,ThiP_synth
HKD1_k127_5447925_2	56780.SYN_01962	6.112e-70	245.0	COG0500@1|root,COG2226@2|Bacteria,1N4AW@1224|Proteobacteria,42UAK@68525|delta/epsilon subdivisions,2WQZC@28221|Deltaproteobacteria,2MR5P@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5467687_6	1094980.Mpsy_2182	3.788e-61	215.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
HKD1_k127_5467687_12	247490.KSU1_C1546	3.471e-08	63.0	COG0727@1|root,COG0727@2|Bacteria,2IZM1@203682|Planctomycetes	203682|Planctomycetes	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_5467687_5	1041930.Mtc_1285	2.251e-80	278.0	COG4020@1|root,arCOG04885@2157|Archaea,2XV89@28890|Euryarchaeota,2N956@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0285 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5467687_4	565033.GACE_1169	2.63e-88	300.0	COG0391@1|root,arCOG04395@2157|Archaea,2XTPP@28890|Euryarchaeota,245YJ@183980|Archaeoglobi	183980|Archaeoglobi	H	Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP	cofD	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HKD1_k127_5467687_8	1094980.Mpsy_2717	4.132e-51	187.0	COG1779@1|root,arCOG04265@2157|Archaea,2XWNA@28890|Euryarchaeota,2N9T4@224756|Methanomicrobia	224756|Methanomicrobia	S	ZPR1-related zinc finger protein	-	-	-	ko:K06874	-	-	-	-	ko00000	-	-	-	zf-ZPR1
HKD1_k127_5467687_11	387631.Asulf_00189	5.536e-21	96.0	COG2450@1|root,arCOG02263@2157|Archaea,2XXYF@28890|Euryarchaeota,2474H@183980|Archaeoglobi	183980|Archaeoglobi	D	Pfam:DUF552	-	-	-	ko:K09152	-	-	-	-	ko00000	-	-	-	SepF
HKD1_k127_5467687_1	1094980.Mpsy_2559	3.355e-105	350.0	COG1060@1|root,arCOG00657@2157|Archaea,2XT78@28890|Euryarchaeota,2N94M@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO)	cofG	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_5467687_9	269797.Mbar_A0292	2.164e-43	162.0	COG1860@1|root,arCOG04477@2157|Archaea,2XX8X@28890|Euryarchaeota,2N9VD@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the UPF0179 family	-	-	-	ko:K09730	-	-	-	-	ko00000	-	-	-	UPF0179
HKD1_k127_5467687_0	192952.MM_0590	6.348e-128	418.0	COG0371@1|root,arCOG00982@2157|Archaea,2XT0F@28890|Euryarchaeota,2N90F@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea	egsA	-	1.1.1.261	ko:K00096	ko00564,map00564	-	R05679,R05680	RC00029	ko00000,ko00001,ko01000	-	-	-	Fe-ADH_2
HKD1_k127_5467687_2	1094980.Mpsy_2218	8.435e-99	328.0	COG1116@1|root,arCOG00193@2157|Archaea,2XT97@28890|Euryarchaeota,2N9FI@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	ssuB	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_5467687_3	269797.Mbar_A1095	1.906e-90	308.0	COG1927@1|root,arCOG04382@2157|Archaea,2XUX3@28890|Euryarchaeota,2N9GS@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methenyl- H(4)MPT( ) to methylene-H(4)MPT	mtd	-	1.5.98.1	ko:K00319	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04456	RC00202	ko00000,ko00001,ko00002,ko01000	-	-	-	MTD
HKD1_k127_5467687_10	868131.MSWAN_0095	7.621e-40	152.0	COG1786@1|root,arCOG04279@2157|Archaea,2XYXJ@28890|Euryarchaeota,23P5Y@183925|Methanobacteria	183925|Methanobacteria	C	Belongs to the UPF0107 family	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
HKD1_k127_5467687_7	1094980.Mpsy_2252	2.692e-52	190.0	COG1679@1|root,arCOG04278@2157|Archaea,2XTY6@28890|Euryarchaeota,2N98R@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
HKD1_k127_5470758_1	593750.Metfor_1407	1.878e-81	279.0	COG0438@1|root,arCOG01410@2157|Archaea	2157|Archaea	M	Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_5470758_2	694427.Palpr_1321	2.201e-50	192.0	COG1216@1|root,COG1216@2|Bacteria,4PMPA@976|Bacteroidetes	976|Bacteroidetes	M	glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5470758_0	868131.MSWAN_1361	4.312e-97	327.0	COG2244@1|root,arCOG02209@2157|Archaea,2XXMT@28890|Euryarchaeota,23PD7@183925|Methanobacteria	28890|Euryarchaeota	S	PFAM Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_5495738_3	589924.Ferp_0804	5.025e-16	81.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,245WW@183980|Archaeoglobi	183980|Archaeoglobi	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_5495738_0	1094980.Mpsy_1014	0.0	1075.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_5495738_1	368407.Memar_0730	2.234e-223	697.0	COG5256@1|root,arCOG01561@2157|Archaea,2XTNM@28890|Euryarchaeota,2N9FZ@224756|Methanomicrobia	224756|Methanomicrobia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03231	ko03013,ko05134,map03013,map05134	-	-	-	ko00000,ko00001,ko03012,ko03016,ko03019,ko04131,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_5495738_2	1041930.Mtc_2154	7.294e-51	181.0	COG0051@1|root,arCOG01758@2157|Archaea,2XXV8@28890|Euryarchaeota,2N9T3@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in the binding of tRNA to the ribosomes	rps10	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD1_k127_5495738_4	192952.MM_1226	3.484e-12	67.0	COG0721@1|root,arCOG02726@2157|Archaea,2XYQ0@28890|Euryarchaeota,2N9Z4@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD1_k127_5503679_0	368407.Memar_1262	8.976e-87	292.0	COG0058@1|root,arCOG01421@2157|Archaea,2XV8J@28890|Euryarchaeota,2NACZ@224756|Methanomicrobia	224756|Methanomicrobia	G	PFAM glycosyl transferase, family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_5503679_1	1121004.ATVC01000009_gene986	6.103e-06	57.0	COG1988@1|root,COG1988@2|Bacteria,1Q0WR@1224|Proteobacteria,2VWGJ@28216|Betaproteobacteria,2KTE6@206351|Neisseriales	206351|Neisseriales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD1_k127_5527737_0	269797.Mbar_A2570	2.271e-66	229.0	COG4119@1|root,arCOG06857@2157|Archaea	2157|Archaea	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_5527737_1	693661.Arcve_2132	9.852e-25	112.0	COG1305@1|root,arCOG03600@2157|Archaea,2Y861@28890|Euryarchaeota,247DH@183980|Archaeoglobi	183980|Archaeoglobi	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_5530160_0	1094980.Mpsy_0915	4.839e-98	329.0	COG1899@1|root,arCOG04142@2157|Archaea,2XSTD@28890|Euryarchaeota,2N91B@224756|Methanomicrobia	224756|Methanomicrobia	O	Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue	dys-2	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD1_k127_5530160_1	269797.Mbar_A1628	2.113e-63	222.0	COG0163@1|root,arCOG01703@2157|Archaea,2XX3R@28890|Euryarchaeota,2N9MQ@224756|Methanomicrobia	224756|Methanomicrobia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_5531767_13	410358.Mlab_0661	1.225e-05	51.0	COG4014@1|root,arCOG04846@2157|Archaea	2157|Archaea	S	Uncharacterized protein conserved in archaea (DUF2098)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2098
HKD1_k127_5531767_7	269797.Mbar_A2888	5.447e-36	142.0	arCOG03197@1|root,arCOG03197@2157|Archaea,2XZKC@28890|Euryarchaeota,2N9ZV@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5531767_12	456442.Mboo_2353	4.946e-08	55.0	arCOG04838@1|root,arCOG04838@2157|Archaea,2Y1E7@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5531767_6	565033.GACE_0370	2.378e-37	147.0	COG0237@1|root,arCOG01045@2157|Archaea,2XWNJ@28890|Euryarchaeota,245NW@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the UPF0200 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17,RNA_binding
HKD1_k127_5531767_8	192952.MM_1366	6.038e-36	147.0	COG1180@1|root,arCOG00952@2157|Archaea,2XZ0I@28890|Euryarchaeota,2N9XE@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM anaerobic ribonucleoside-triphosphate reductase activating protein	nrdG	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_5531767_11	1094980.Mpsy_1543	1.116e-10	74.0	arCOG05201@1|root,arCOG05201@2157|Archaea	2157|Archaea	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5531767_1	192952.MM_0425	7.466e-214	685.0	COG1204@1|root,arCOG00553@2157|Archaea,2XSV4@28890|Euryarchaeota,2N9A8@224756|Methanomicrobia	224756|Methanomicrobia	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
HKD1_k127_5531767_2	1123376.AUIU01000013_gene1914	3.224e-144	469.0	COG0436@1|root,COG0436@2|Bacteria,3J0G2@40117|Nitrospirae	40117|Nitrospirae	E	Aminotransferase class I and II	-	-	2.6.1.83	ko:K10206	ko00300,ko01100,ko01110,ko01130,ko01230,map00300,map01100,map01110,map01130,map01230	M00527	R07613	RC00006,RC01847	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_5531767_0	269797.Mbar_A2048	0.0	1200.0	COG0495@1|root,arCOG00809@2157|Archaea,2XU7M@28890|Euryarchaeota,2N99R@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1g
HKD1_k127_5531767_4	192952.MM_2033	1.893e-96	323.0	COG0330@1|root,arCOG01915@2157|Archaea,2XTA2@28890|Euryarchaeota,2N9RK@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_5531767_3	1094980.Mpsy_1830	2.546e-125	415.0	COG1030@1|root,arCOG01910@2157|Archaea,2XW1R@28890|Euryarchaeota,2NAHP@224756|Methanomicrobia	224756|Methanomicrobia	O	Clp protease	-	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	CLP_protease,NfeD
HKD1_k127_5531767_9	748247.AZKH_2757	2.436e-33	134.0	COG0426@1|root,COG0426@2|Bacteria,1N4CQ@1224|Proteobacteria	1224|Proteobacteria	C	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_5531767_10	387631.Asulf_01364	2.244e-15	79.0	COG3335@1|root,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_32,HTH_33
HKD1_k127_5531767_5	1041930.Mtc_1759	1.011e-71	249.0	COG0464@1|root,arCOG04368@2157|Archaea,2XT63@28890|Euryarchaeota,2N9B2@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_5538780_0	555079.Toce_0785	1.042e-243	769.0	COG3383@1|root,COG3383@2|Bacteria,1TT6D@1239|Firmicutes,24YN9@186801|Clostridia,42FDP@68295|Thermoanaerobacterales	186801|Clostridia	C	Formate dehydrogenase alpha subunit	fdhA	-	1.17.1.10,1.17.1.11,1.17.1.9	ko:K00123,ko:K05299,ko:K22341	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Molybdop_Fe4S4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD1_k127_5538780_1	760568.Desku_1431	8.439e-45	174.0	COG1150@1|root,COG1150@2|Bacteria,1UJJ4@1239|Firmicutes,25F45@186801|Clostridia,267CZ@186807|Peptococcaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22,Fer4_4
HKD1_k127_5539227_0	368407.Memar_0496	1.973e-20	91.0	arCOG03397@1|root,arCOG03397@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5542481_2	1227349.C170_05333	8.294e-129	419.0	COG0154@1|root,COG0154@2|Bacteria,1TP0C@1239|Firmicutes,4HBAZ@91061|Bacilli,26RDQ@186822|Paenibacillaceae	91061|Bacilli	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_5542481_1	1094980.Mpsy_1326	2.175e-192	610.0	COG0064@1|root,arCOG01718@2157|Archaea,2XSV3@28890|Euryarchaeota,2N981@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_5542481_0	1094980.Mpsy_2737	9.058e-199	629.0	COG1541@1|root,arCOG02620@2157|Archaea,2XU3A@28890|Euryarchaeota,2N95A@224756|Methanomicrobia	224756|Methanomicrobia	H	AMP-binding enzyme C-terminal domain	paaK-2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_5542481_3	192952.MM_0677	6.48e-16	78.0	COG4747@1|root,arCOG04444@2157|Archaea,2XXTI@28890|Euryarchaeota,2N9SE@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM amino acid-binding ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD1_k127_5564425_7	7739.XP_002607038.1	1.155e-19	101.0	COG2335@1|root,KOG1437@2759|Eukaryota,39MP0@33154|Opisthokonta,3BB62@33208|Metazoa,3E481@33213|Bilateria	33208|Metazoa	MW	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	ko:K19519	-	-	-	-	ko00000,ko04516	-	-	-	Fasciclin
HKD1_k127_5564425_6	113355.CM001775_gene1975	1.879e-26	113.0	COG0642@1|root,COG3452@1|root,COG2205@2|Bacteria,COG3452@2|Bacteria,1GD32@1117|Cyanobacteria	1117|Cyanobacteria	T	CHASE	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,HATPase_c,HisKA,Response_reg
HKD1_k127_5564425_8	573063.Metin_0860	1.567e-15	79.0	COG0517@1|root,arCOG00606@2157|Archaea,2XX11@28890|Euryarchaeota,23QUR@183939|Methanococci	183939|Methanococci	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_5564425_4	192952.MM_1466	2.261e-37	145.0	COG3677@1|root,arCOG02137@2157|Archaea	2157|Archaea	L	transposition, DNA-mediated	-	-	-	-	-	-	-	-	-	-	-	-	Zn_Tnp_IS1595
HKD1_k127_5564425_1	1094980.Mpsy_1339	1.655e-62	224.0	arCOG02575@1|root,arCOG02575@2157|Archaea,2XZ2N@28890|Euryarchaeota,2NAAE@224756|Methanomicrobia	224756|Methanomicrobia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_5564425_9	1123388.AQWU01000053_gene1547	2.365e-09	61.0	COG2329@1|root,COG2329@2|Bacteria,1WNCW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_5564425_0	880073.Calab_0699	8.438e-156	511.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria,2NQMI@2323|unclassified Bacteria	2|Bacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HATPase_c,HisKA,Hpt,Reg_prop,Response_reg,Y_Y_Y
HKD1_k127_5564425_3	1121445.ATUZ01000015_gene1934	1.532e-42	169.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,42M0W@68525|delta/epsilon subdivisions,2WIK8@28221|Deltaproteobacteria,2M8CQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Diguanylate cyclase phosphodiesterase with PAS PAC sensor(S)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_3,PAS_4,PilJ,Response_reg
HKD1_k127_5564425_5	351160.RCIX1082	2.593e-29	125.0	COG0642@1|root,arCOG03567@1|root,arCOG06516@1|root,arCOG03567@2157|Archaea,arCOG06192@2157|Archaea,arCOG06516@2157|Archaea,2Y7NU@28890|Euryarchaeota,2NAAT@224756|Methanomicrobia	224756|Methanomicrobia	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_3
HKD1_k127_5564425_2	269797.Mbar_A3250	1.093e-53	192.0	COG0642@1|root,arCOG03567@1|root,arCOG02358@2157|Archaea,arCOG03567@2157|Archaea,2Y7NU@28890|Euryarchaeota,2NAAT@224756|Methanomicrobia	224756|Methanomicrobia	T	MEDS: MEthanogen/methylotroph, DcmR Sensory domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MEDS,PAS_3
HKD1_k127_5583787_3	311424.DhcVS_35	1.002e-81	281.0	COG0543@1|root,COG0543@2|Bacteria,2GAKZ@200795|Chloroflexi,34CQB@301297|Dehalococcoidia	301297|Dehalococcoidia	C	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	DHODB_Fe-S_bind
HKD1_k127_5583787_2	192952.MM_1362	1.748e-113	374.0	COG0715@1|root,arCOG01803@2157|Archaea,2XV39@28890|Euryarchaeota,2N923@224756|Methanomicrobia	224756|Methanomicrobia	P	ABC transporter, substrate-binding protein, aliphatic	ssuA	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD1_k127_5583787_0	1041930.Mtc_1599	5.32e-229	715.0	COG1103@1|root,arCOG07472@1|root,arCOG00091@2157|Archaea,arCOG07472@2157|Archaea,2XU3S@28890|Euryarchaeota,2NA7Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys))	-	-	2.5.1.73	ko:K06868	ko00970,map00970	-	R08577	RC02948	ko00000,ko00001,ko01000,ko03016	-	-	-	Aminotran_5,SepSecS
HKD1_k127_5583787_1	456442.Mboo_2044	3.724e-215	674.0	COG2873@1|root,arCOG00061@2157|Archaea,2XSWM@28890|Euryarchaeota,2N9AN@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Cys Met metabolism	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_5589897_6	1120950.KB892805_gene1511	2.397e-05	49.0	COG1073@1|root,COG1073@2|Bacteria,2IPVI@201174|Actinobacteria	201174|Actinobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5589897_2	1297570.MESS4_690031	3.59e-163	533.0	COG1032@1|root,COG1032@2|Bacteria,1NAY8@1224|Proteobacteria,2TV1I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_5589897_5	237727.NAP1_03050	3.18e-09	58.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TUT8@28211|Alphaproteobacteria,2K30M@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_5589897_7	1343739.PAP_01865	3.922e-05	47.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota	28890|Euryarchaeota	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	pdhD	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	1.8.1.4,1.8.1.7	ko:K00382,ko:K00383	ko00010,ko00020,ko00260,ko00280,ko00480,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04918,map00010,map00020,map00260,map00280,map00480,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04918	M00009,M00011,M00036,M00307,M00532	R00094,R00115,R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00011,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iAF692.Mbar_A3561	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_5589897_3	521011.Mpal_0666	1.528e-76	261.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTXN@28890|Euryarchaeota,2NBJV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.4,1.8.1.7	ko:K00382,ko:K00383	ko00010,ko00020,ko00260,ko00280,ko00480,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04918,map00010,map00020,map00260,map00280,map00480,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map04918	M00009,M00011,M00036,M00307,M00532	R00094,R00115,R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00011,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2
HKD1_k127_5589897_0	269797.Mbar_A2871	7.042e-229	726.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5589897_4	521011.Mpal_1231	5.817e-40	169.0	COG4978@1|root,arCOG03200@2157|Archaea,2XYDM@28890|Euryarchaeota,2NBJ9@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription activator, effector binding	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD1_k127_5589897_1	351160.RCIX2731	8.924e-199	631.0	COG0557@1|root,arCOG04686@2157|Archaea,2XT2E@28890|Euryarchaeota,2NA9N@224756|Methanomicrobia	224756|Methanomicrobia	K	PFAM ribonuclease II	-	-	3.1.13.1	ko:K01147	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNB
HKD1_k127_5605488_0	269797.Mbar_A0707	2.541e-214	677.0	COG1123@1|root,arCOG00185@2157|Archaea,2Y7KQ@28890|Euryarchaeota,2N960@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter	atw-1	-	-	ko:K00400	ko00680,ko01100,ko01120,map00680,map01100,map01120	-	-	-	ko00000,ko00001	-	-	-	ABC_tran
HKD1_k127_5605488_1	386456.JQKN01000001_gene1934	3.137e-34	138.0	COG4070@1|root,arCOG04900@2157|Archaea,2XU32@28890|Euryarchaeota,23PAG@183925|Methanobacteria	183925|Methanobacteria	O	Belongs to the UPF0288 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5613862_4	269797.Mbar_A0851	8.478e-67	238.0	COG0342@1|root,arCOG03055@2157|Archaea,2XU5A@28890|Euryarchaeota,2N9BA@224756|Methanomicrobia	224756|Methanomicrobia	U	Protein-export membrane protein SecD	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
HKD1_k127_5613862_3	1094980.Mpsy_2173	1.917e-79	274.0	COG0341@1|root,arCOG03054@2157|Archaea,2XTMX@28890|Euryarchaeota,2N9GN@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in protein export	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_5613862_0	1094980.Mpsy_1396	2.399e-168	538.0	COG0269@1|root,arCOG00053@2157|Archaea,2XV47@28890|Euryarchaeota,2N9E0@224756|Methanomicrobia	224756|Methanomicrobia	G	Orotidine 5'-phosphate decarboxylase	-	-	4.1.2.43,5.3.1.27	ko:K13831	ko00030,ko00680,ko01100,ko01120,ko01200,ko01230,map00030,map00680,map01100,map01120,map01200,map01230	M00345,M00580	R05338,R05339,R09780	RC00377,RC00421,RC00422	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase,RraA-like
HKD1_k127_5613862_2	1041930.Mtc_1408	3.522e-87	297.0	COG0253@1|root,arCOG02255@2157|Archaea,2XUYX@28890|Euryarchaeota,2NAG6@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD1_k127_5613862_1	269797.Mbar_A1752	4.386e-162	523.0	COG0608@1|root,arCOG00427@2157|Archaea,2XT8Y@28890|Euryarchaeota,2N99F@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM phosphoesterase, RecJ domain protein	recJ	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
HKD1_k127_5613862_5	3847.GLYMA09G33390.1	3.042e-27	115.0	COG1064@1|root,KOG0023@2759|Eukaryota,37KEI@33090|Viridiplantae,3G8HT@35493|Streptophyta	35493|Streptophyta	Q	Dehydrogenase	-	-	1.1.1.195	ko:K00083	ko00940,ko01100,ko01110,map00940,map01100,map01110	M00039	R02593,R03918,R06570,R06571,R07437	RC00649	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5613862_6	33876.JNXY01000029_gene2782	3.21e-18	90.0	COG1064@1|root,COG1064@2|Bacteria,2GNVQ@201174|Actinobacteria,4DB44@85008|Micromonosporales	201174|Actinobacteria	S	alcohol dehydrogenase	adhA	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5613862_8	1316932.MHH_c02720	3.034e-09	64.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1Y887@135625|Pasteurellales	135625|Pasteurellales	S	D-isomer specific 2-hydroxyacid dehydrogenase family protein of Proteobacteria UniRef RepID Q4KE06_PSEF5	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5613862_7	1177179.A11A3_13395	3.467e-18	88.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1XHWM@135619|Oceanospirillales	135619|Oceanospirillales	S	Dehydrogenase	-	-	-	ko:K12957,ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_563071_3	357804.Ping_2144	4.006e-20	94.0	COG4412@1|root,COG4412@2|Bacteria,1MWWV@1224|Proteobacteria,1RZM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG1404 Subtilisin-like serine proteases	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M6
HKD1_k127_563071_0	1094980.Mpsy_2337	1.099e-93	314.0	COG0496@1|root,arCOG02303@2157|Archaea,2XT5R@28890|Euryarchaeota,2N9DM@224756|Methanomicrobia	224756|Methanomicrobia	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	iAF692.Mbar_A1192	SurE
HKD1_k127_563071_2	192952.MM_1505	2.675e-45	170.0	COG0131@1|root,arCOG04398@2157|Archaea,2XT2K@28890|Euryarchaeota,2N9NB@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1310	IGPD
HKD1_k127_563071_1	523845.AQXV01000051_gene1282	7.614e-54	195.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,23QJK@183939|Methanococci	183939|Methanococci	E	TIGRFAM Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_563071_4	1094980.Mpsy_1891	6.896e-16	78.0	COG0106@1|root,arCOG00618@2157|Archaea,2XSUF@28890|Euryarchaeota,2N949@224756|Methanomicrobia	224756|Methanomicrobia	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_5667238_2	237368.SCABRO_01637	1.095e-111	367.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_5667238_3	593750.Metfor_0761	1.06e-99	332.0	COG1013@1|root,arCOG01599@2157|Archaea,2XTW2@28890|Euryarchaeota,2N9NQ@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Thiamine pyrophosphate	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD1_k127_5667238_0	368407.Memar_2031	4.303e-194	619.0	COG0674@1|root,arCOG01606@2157|Archaea,2XSUJ@28890|Euryarchaeota,2N91I@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyruvate flavodoxin ferredoxin oxidoreductase domain protein	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD1_k127_5667238_1	373994.Riv7116_5450	2.592e-130	440.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HMEM@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_9,Response_reg
HKD1_k127_5688968_0	311424.DhcVS_767	2.553e-215	677.0	COG1894@1|root,COG1894@2|Bacteria,2G5K9@200795|Chloroflexi,34D1V@301297|Dehalococcoidia	301297|Dehalococcoidia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD1_k127_5688968_1	316067.Geob_0217	5.55e-45	168.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,42RCD@68525|delta/epsilon subdivisions,2WMUP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	bamG	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_5724045_0	1094980.Mpsy_1484	3.09e-67	234.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,2N9IK@224756|Methanomicrobia	224756|Methanomicrobia	L	SMART DNA-directed DNA polymerase B	polB-1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
HKD1_k127_5724045_1	521460.Athe_2428	1.181e-20	95.0	COG0328@1|root,COG0328@2|Bacteria,1VI1T@1239|Firmicutes,24U8C@186801|Clostridia,42HK4@68295|Thermoanaerobacterales	186801|Clostridia	L	PFAM ribonuclease H	-	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RVT_3,SWIM
HKD1_k127_5787836_1	5888.CAK86537	2.264e-22	102.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_5787836_0	192952.MM_3293	5.219e-142	454.0	COG1600@1|root,arCOG02740@2157|Archaea,2Y47Z@28890|Euryarchaeota,2NAXR@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_5787836_2	335543.Sfum_0673	1.835e-06	49.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,42PYS@68525|delta/epsilon subdivisions,2WMEG@28221|Deltaproteobacteria,2MRGX@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_5789571_0	269797.Mbar_A1252	1.604e-128	415.0	COG1690@1|root,arCOG04246@2157|Archaea,2XTIC@28890|Euryarchaeota,2N90W@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the RtcB family	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD1_k127_5789571_2	420247.Msm_0223	3.916e-05	48.0	arCOG04838@1|root,arCOG04838@2157|Archaea,2Y1E7@28890|Euryarchaeota,23PTY@183925|Methanobacteria	183925|Methanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5789571_1	1410609.JHVB01000001_gene1759	4.9e-08	57.0	COG2968@1|root,COG2968@2|Bacteria,2J8B1@203691|Spirochaetes	203691|Spirochaetes	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD1_k127_5795185_9	335543.Sfum_0687	3.077e-10	72.0	COG1413@1|root,COG1413@2|Bacteria,1P1H4@1224|Proteobacteria,431VX@68525|delta/epsilon subdivisions,2WWU3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5795185_4	1121405.dsmv_3662	4.666e-21	94.0	COG0582@1|root,COG0582@2|Bacteria,1RCN8@1224|Proteobacteria,42RD9@68525|delta/epsilon subdivisions,2WMVF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	viral genome integration into host DNA	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_integrase
HKD1_k127_5795185_5	56780.SYN_01430	3.405e-18	95.0	COG2197@1|root,COG4191@1|root,COG2197@2|Bacteria,COG4191@2|Bacteria,1R7ED@1224|Proteobacteria,42PQ7@68525|delta/epsilon subdivisions,2WMHZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_8
HKD1_k127_5795185_7	1304885.AUEY01000001_gene3172	1.107e-16	86.0	COG1639@1|root,COG1639@2|Bacteria,1RBFE@1224|Proteobacteria,42QRK@68525|delta/epsilon subdivisions,2WMYG@28221|Deltaproteobacteria,2MJHI@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,zinc_ribbon_4
HKD1_k127_5795185_10	439235.Dalk_2383	4.329e-06	51.0	COG1639@1|root,COG1639@2|Bacteria,1RBFE@1224|Proteobacteria,42QRK@68525|delta/epsilon subdivisions,2WMYG@28221|Deltaproteobacteria,2MJHI@213118|Desulfobacterales	28221|Deltaproteobacteria	T	HDOD domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,zinc_ribbon_4
HKD1_k127_5795185_2	909663.KI867150_gene440	1.841e-35	141.0	COG2203@1|root,COG4191@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MRI2@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Signal transduction response regulator, receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HKD1_k127_5795185_3	933262.AXAM01000059_gene2913	1.351e-30	124.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIZU@28221|Deltaproteobacteria,2MI2B@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg
HKD1_k127_5795185_6	644282.Deba_2688	1.049e-16	82.0	COG0745@1|root,COG2202@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_5795185_11	933262.AXAM01000004_gene2376	0.0004734	47.0	2CA0U@1|root,2ZV8M@2|Bacteria,1P9XY@1224|Proteobacteria,432NR@68525|delta/epsilon subdivisions,2WY02@28221|Deltaproteobacteria,2MP2P@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD1_k127_5795185_0	933262.AXAM01000037_gene886	4.369e-103	349.0	COG2204@1|root,COG2204@2|Bacteria,1QWNE@1224|Proteobacteria,43BTE@68525|delta/epsilon subdivisions,2X746@28221|Deltaproteobacteria,2MPJR@213118|Desulfobacterales	28221|Deltaproteobacteria	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_5795185_1	1121405.dsmv_0797	2.152e-64	226.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,42SMN@68525|delta/epsilon subdivisions,2WPJN@28221|Deltaproteobacteria,2MNCE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD1_k127_5795185_8	439235.Dalk_1692	6.021e-13	73.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MFW@68525|delta/epsilon subdivisions,2WKMP@28221|Deltaproteobacteria,2MI6S@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_3,PAS_9,Response_reg
HKD1_k127_5802053_0	237368.SCABRO_01637	6.293e-67	230.0	COG0058@1|root,COG0058@2|Bacteria,2IY0J@203682|Planctomycetes	203682|Planctomycetes	G	COG0058 Glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_5802053_5	290512.Paes_1977	0.0002009	46.0	COG0071@1|root,COG0071@2|Bacteria,1FF1I@1090|Chlorobi	1090|Chlorobi	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_5802053_2	368407.Memar_1503	5.847e-22	97.0	COG1141@1|root,arCOG00349@2157|Archaea	2157|Archaea	C	Ferredoxin	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	DnaJ,Fer4_13,Fer4_15
HKD1_k127_5802053_1	1220534.B655_1291	2.514e-57	205.0	COG0778@1|root,arCOG00288@2157|Archaea,2XZHP@28890|Euryarchaeota	28890|Euryarchaeota	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
HKD1_k127_5802053_3	386456.JQKN01000014_gene3151	4.526e-06	56.0	COG4880@1|root,arCOG03545@2157|Archaea	2157|Archaea	L	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Beta_propel,Inhibitor_I42
HKD1_k127_5802053_4	269797.Mbar_A2871	8.86e-06	48.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5823499_1	439235.Dalk_3756	1.71e-168	546.0	COG1001@1|root,COG1001@2|Bacteria,1MVFP@1224|Proteobacteria,42NWX@68525|delta/epsilon subdivisions,2WIZY@28221|Deltaproteobacteria,2MJ6T@213118|Desulfobacterales	28221|Deltaproteobacteria	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HKD1_k127_5823499_0	1230460.C495_16173	1.768e-320	995.0	COG0464@1|root,arCOG01308@2157|Archaea,2XSYR@28890|Euryarchaeota,23RXX@183963|Halobacteria	183963|Halobacteria	O	COG0464 ATPases of the AAA class	cdc48a	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_5823499_2	269797.Mbar_A2322	1.327e-15	79.0	COG1873@1|root,arCOG02155@2157|Archaea,2XYZ2@28890|Euryarchaeota,2NA15@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_5830217_1	290315.Clim_0049	2.181e-14	77.0	2C54Q@1|root,3498C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5830217_0	1094980.Mpsy_1243	2.762e-21	96.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_5830217_3	1094980.Mpsy_0033	5.859e-07	51.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_5830217_2	1094980.Mpsy_0550	3.868e-13	70.0	COG3039@1|root,arCOG06508@2157|Archaea	2157|Archaea	L	transposase activity	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_5867007_13	269797.Mbar_A0603	7.919e-13	71.0	COG1912@1|root,arCOG04309@2157|Archaea,2XUEW@28890|Euryarchaeota,2N9T8@224756|Methanomicrobia	224756|Methanomicrobia	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD1_k127_5867007_2	1094980.Mpsy_2035	3.534e-130	423.0	COG2141@1|root,arCOG02410@2157|Archaea,2XTN9@28890|Euryarchaeota,2N9DT@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the reversible reduction of methylene-H(4)MPT to methyl-H(4)MPT	mer	-	1.5.98.2	ko:K00320	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R04464	RC01607	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0254	Bac_luciferase
HKD1_k127_5867007_6	192952.MM_0626	1.019e-58	207.0	COG1056@1|root,arCOG00972@2157|Archaea,2XUF7@28890|Euryarchaeota,2N9N1@224756|Methanomicrobia	224756|Methanomicrobia	F	cytidyltransferase-related domain	nadR	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
HKD1_k127_5867007_4	693661.Arcve_1074	2.078e-119	396.0	COG0560@1|root,arCOG01158@2157|Archaea,2XT0C@28890|Euryarchaeota,2462F@183980|Archaeoglobi	183980|Archaeoglobi	E	phosphoserine phosphatase SerB	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	ACT_6,HAD
HKD1_k127_5867007_7	589924.Ferp_0033	3.313e-49	181.0	COG2238@1|root,arCOG01344@2157|Archaea,2XXA6@28890|Euryarchaeota,24658@183980|Archaeoglobi	183980|Archaeoglobi	J	May be involved in maturation of the 30S ribosomal subunit	rps19e	-	-	ko:K02966	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19e
HKD1_k127_5867007_9	679926.Mpet_1846	5.289e-26	111.0	COG2118@1|root,arCOG04179@2157|Archaea,2XZUR@28890|Euryarchaeota,2N9ZR@224756|Methanomicrobia	224756|Methanomicrobia	S	Belongs to the PDCD5 family	-	-	-	ko:K06875	-	-	-	-	ko00000	-	-	-	dsDNA_bind
HKD1_k127_5867007_8	351160.RCIX1045	6.124e-46	173.0	COG2117@1|root,arCOG00037@2157|Archaea,2XTGQ@28890|Euryarchaeota,2N9S4@224756|Methanomicrobia	224756|Methanomicrobia	J	subunit of tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase contains the PP-loop ATPase domain	-	-	-	ko:K07585	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_5867007_12	410358.Mlab_1480	1.022e-13	73.0	COG2167@1|root,arCOG04177@2157|Archaea,2XZSY@28890|Euryarchaeota	28890|Euryarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
HKD1_k127_5867007_10	410358.Mlab_1479	5.302e-25	106.0	COG2097@1|root,arCOG04473@2157|Archaea,2XYWX@28890|Euryarchaeota,2N9YU@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eukaryotic ribosomal protein eL31 family	rpl31e	-	-	ko:K02910	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31e
HKD1_k127_5867007_5	269797.Mbar_A0459	1.369e-62	222.0	COG1976@1|root,arCOG04176@2157|Archaea,2XU7N@28890|Euryarchaeota,2N9JT@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
HKD1_k127_5867007_14	679926.Mpet_1851	5.188e-05	48.0	COG2157@1|root,arCOG04175@2157|Archaea,2Y6W8@28890|Euryarchaeota,2NA5B@224756|Methanomicrobia	224756|Methanomicrobia	J	Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A	rplX	-	-	ko:K02944	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18A
HKD1_k127_5867007_11	304371.MCP_0009	2.005e-20	96.0	COG1730@1|root,arCOG01341@2157|Archaea,2Y0EU@28890|Euryarchaeota,2NBIM@224756|Methanomicrobia	224756|Methanomicrobia	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
HKD1_k127_5867007_3	192952.MM_0810	6.95e-123	406.0	COG0552@1|root,arCOG01227@2157|Archaea,2XUBI@28890|Euryarchaeota,2N9A4@224756|Methanomicrobia	224756|Methanomicrobia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_5867007_0	192952.MM_1291	3.961e-198	627.0	COG0277@1|root,arCOG00337@2157|Archaea,2XT5C@28890|Euryarchaeota,2N96T@224756|Methanomicrobia	224756|Methanomicrobia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_5867007_1	192952.MM_1290	4.003e-135	438.0	COG0247@1|root,arCOG00333@2157|Archaea,2Y85G@28890|Euryarchaeota,2NBI0@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	CCG,Fer4_8
HKD1_k127_5868363_1	1054217.TALC_01503	1.64e-26	116.0	COG0491@1|root,arCOG00504@2157|Archaea,2Y00C@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_5868363_0	323259.Mhun_0824	9.966e-171	546.0	COG0015@1|root,arCOG01747@2157|Archaea,2XUQ5@28890|Euryarchaeota,2N963@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD1_k127_5870298_1	1035308.AQYY01000001_gene1487	3.839e-09	64.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
HKD1_k127_5870298_0	192952.MM_3113	7.014e-190	604.0	COG1164@1|root,arCOG04758@2157|Archaea,2XSX1@28890|Euryarchaeota	28890|Euryarchaeota	E	oligoendopeptidase F	pepF	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD1_k127_5870706_2	1267533.KB906735_gene5083	1.573e-07	57.0	COG0076@1|root,COG0076@2|Bacteria,3Y3S7@57723|Acidobacteria,2JJ5R@204432|Acidobacteriia	204432|Acidobacteriia	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD1_k127_5870706_0	335543.Sfum_0920	2.284e-43	162.0	COG0500@1|root,COG1846@1|root,COG1846@2|Bacteria,COG2226@2|Bacteria,1MW7J@1224|Proteobacteria,43BRY@68525|delta/epsilon subdivisions,2X72R@28221|Deltaproteobacteria,2MQCD@213462|Syntrophobacterales	28221|Deltaproteobacteria	KQ	Dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_5870706_1	552811.Dehly_1001	7.56e-23	103.0	COG0607@1|root,COG0607@2|Bacteria,2G71Z@200795|Chloroflexi,34DDK@301297|Dehalococcoidia	301297|Dehalococcoidia	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_5874035_0	304371.MCP_0210	6.577e-30	123.0	COG0463@1|root,arCOG01386@2157|Archaea,2Y7ST@28890|Euryarchaeota	28890|Euryarchaeota	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5890704_1	868131.MSWAN_2227	9.151e-23	99.0	COG2146@1|root,arCOG02852@2157|Archaea,2XUZH@28890|Euryarchaeota	28890|Euryarchaeota	P	COG2146 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Rieske_2
HKD1_k127_5890704_0	1094980.Mpsy_0307	4.812e-52	191.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y2AR@28890|Euryarchaeota,2NA7W@224756|Methanomicrobia	224756|Methanomicrobia	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
HKD1_k127_5890704_2	1123226.KB899314_gene1697	0.0003166	44.0	COG3871@1|root,COG3871@2|Bacteria,1V6MX@1239|Firmicutes,4HIYZ@91061|Bacilli,26WSM@186822|Paenibacillaceae	91061|Bacilli	S	general stress protein	ydaG	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx,Pyrid_ox_like
HKD1_k127_5896801_2	523841.HFX_0193	1.564e-11	65.0	COG1474@1|root,arCOG00467@2157|Archaea,2XTRB@28890|Euryarchaeota,23S2H@183963|Halobacteria	183963|Halobacteria	L	Involved in regulation of DNA replication	cdc6	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA_16
HKD1_k127_5896801_0	1094980.Mpsy_2937	1.365e-217	692.0	COG2511@1|root,arCOG01719@2157|Archaea,2XT73@28890|Euryarchaeota,2N9BR@224756|Methanomicrobia	224756|Methanomicrobia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
HKD1_k127_5896801_1	604354.TSIB_1481	3.206e-16	80.0	COG2036@1|root,arCOG02144@2157|Archaea,2XZYK@28890|Euryarchaeota,244HP@183968|Thermococci	183968|Thermococci	L	Binds and compact DNA (95 to 150 base pairs) to form nucleosome-like structures that contain positive DNA supercoils. Increases the resistance of DNA to thermal denaturation	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
HKD1_k127_5897339_0	1094980.Mpsy_2655	9.049e-73	253.0	COG1055@1|root,arCOG00238@2157|Archaea,2XVDU@28890|Euryarchaeota,2N961@224756|Methanomicrobia	224756|Methanomicrobia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD1_k127_5918693_1	868131.MSWAN_1273	7.112e-31	133.0	COG2244@1|root,arCOG02209@2157|Archaea,2XSUR@28890|Euryarchaeota,23PBE@183925|Methanobacteria	183925|Methanobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_5918693_0	457570.Nther_2533	1.212e-87	309.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia	1239|Firmicutes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_5918693_2	457570.Nther_2533	2.87e-13	73.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia	1239|Firmicutes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_5926181_1	28072.Nos7524_1324	4.09e-36	142.0	COG1501@1|root,COG1501@2|Bacteria,1G4DY@1117|Cyanobacteria,1HTYS@1161|Nostocales	1117|Cyanobacteria	G	Domain of unknown function (DUF4968)	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_5926181_0	395494.Galf_2689	2.007e-127	419.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,2VKNG@28216|Betaproteobacteria,44UYU@713636|Nitrosomonadales	28216|Betaproteobacteria	J	S-adenosylmethionine-dependent methyltransferase	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD1_k127_5936688_1	1094980.Mpsy_0639	6.513e-05	47.0	COG1533@1|root,arCOG01290@2157|Archaea,2XY2A@28890|Euryarchaeota,2N9Z2@224756|Methanomicrobia	224756|Methanomicrobia	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_5936688_0	1210908.HSB1_39710	2.709e-68	242.0	COG0385@1|root,arCOG02191@2157|Archaea,2XWY8@28890|Euryarchaeota,23WFA@183963|Halobacteria	183963|Halobacteria	S	Sodium Bile acid symporter family	-	-	-	-	-	-	-	-	-	-	-	-	SBF
HKD1_k127_5937382_2	269797.Mbar_A0058	1.306e-130	429.0	COG4231@1|root,arCOG01609@2157|Archaea,2XUNR@28890|Euryarchaeota,2N93H@224756|Methanomicrobia	224756|Methanomicrobia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,POR_N,TPP_enzyme_C
HKD1_k127_5937382_5	1094980.Mpsy_1147	5.206e-58	207.0	COG1014@1|root,arCOG01602@2157|Archaea,2XXK2@28890|Euryarchaeota,2N9JS@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_5937382_8	357808.RoseRS_3392	2.646e-11	71.0	COG1413@1|root,COG1413@2|Bacteria,2G6UU@200795|Chloroflexi	200795|Chloroflexi	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HKD1_k127_5937382_0	192952.MM_1486	0.0	1088.0	COG0013@1|root,arCOG01255@2157|Archaea,2XSXB@28890|Euryarchaeota,2N92P@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_5937382_4	304371.MCP_0828	1.83e-58	209.0	COG0856@1|root,arCOG00028@2157|Archaea,2XU2R@28890|Euryarchaeota,2N9NM@224756|Methanomicrobia	224756|Methanomicrobia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	pyrE-2	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_5937382_6	572546.Arcpr_0187	1.005e-28	120.0	COG1439@1|root,arCOG00721@2157|Archaea,2XWH2@28890|Euryarchaeota,246A8@183980|Archaeoglobi	183980|Archaeoglobi	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
HKD1_k127_5937382_7	192952.MM_0427	9.725e-20	94.0	arCOG02206@1|root,arCOG02206@2157|Archaea,2Y17T@28890|Euryarchaeota,2NA3Y@224756|Methanomicrobia	224756|Methanomicrobia	S	RNase L inhibitor, RLI	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5937382_1	1041930.Mtc_0004	9.577e-241	756.0	COG1245@1|root,arCOG00187@2157|Archaea,2XSZE@28890|Euryarchaeota,2N9CQ@224756|Methanomicrobia	224756|Methanomicrobia	E	in RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
HKD1_k127_5937382_3	1254432.SCE1572_37960	3.089e-73	250.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,42Q8W@68525|delta/epsilon subdivisions,2WJVN@28221|Deltaproteobacteria,2YWG3@29|Myxococcales	28221|Deltaproteobacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
HKD1_k127_5950645_2	1041930.Mtc_1805	7.088e-05	48.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD1_k127_5950645_0	351160.RRC178	1.26e-38	147.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD1_k127_5950645_1	768672.Desfe_1357	7.628e-06	50.0	COG1370@1|root,arCOG00991@2157|Archaea,2XQDH@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM PUA domain	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
HKD1_k127_5950645_3	1289135.A966_04706	0.0003061	48.0	COG0834@1|root,COG0834@2|Bacteria,2J6U3@203691|Spirochaetes	203691|Spirochaetes	ET	Belongs to the bacterial solute-binding protein 3 family	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_5967242_0	1161401.ASJA01000025_gene210	5.666e-37	149.0	COG0457@1|root,COG0457@2|Bacteria,1RCUA@1224|Proteobacteria,2U8NP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD1_k127_5984604_2	192952.MM_1828	1.399e-46	171.0	COG0439@1|root,arCOG01590@2157|Archaea,2Y8CM@28890|Euryarchaeota,2N91K@224756|Methanomicrobia	224756|Methanomicrobia	I	Carbamoyl-phosphate synthetase large chain domain protein	pycA	-	6.4.1.1	ko:K01959	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173,M00620	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	BPL_C,BPL_LplA_LipB,Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_5984604_0	192952.MM_1829	1.004e-73	259.0	COG0340@1|root,arCOG01940@2157|Archaea,2XSZ5@28890|Euryarchaeota,2N982@224756|Methanomicrobia	224756|Methanomicrobia	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_5984604_3	1094980.Mpsy_0362	1.312e-42	162.0	COG1310@1|root,arCOG01139@2157|Archaea,2XWKU@28890|Euryarchaeota,2N9TM@224756|Methanomicrobia	224756|Methanomicrobia	S	Prokaryotic homologs of the JAB domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
HKD1_k127_5984604_1	572546.Arcpr_1573	8.249e-51	183.0	COG0615@1|root,arCOG01222@2157|Archaea,2XX70@28890|Euryarchaeota,2467U@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme	ribL	-	2.7.7.2	ko:K14656	ko00740,ko01100,ko01110,map00740,map01100,map01110	-	R00161	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
HKD1_k127_5984604_4	192952.MM_0458	2.81e-38	149.0	COG1986@1|root,arCOG01223@2157|Archaea,2XWGY@28890|Euryarchaeota,2N9RM@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM cytidyltransferase-related domain	coaD	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_5984604_6	1210908.HSB1_09600	1.623e-06	52.0	COG0613@1|root,arCOG00302@2157|Archaea,2XSWE@28890|Euryarchaeota,23TEN@183963|Halobacteria	183963|Halobacteria	S	metal-dependent phosphoesterases (PHP family)	-	-	-	-	-	-	-	-	-	-	-	-	PHP,PHP_C
HKD1_k127_5984604_5	267377.MMP0181	1.088e-12	72.0	arCOG07632@1|root,arCOG07632@2157|Archaea,2Y4M1@28890|Euryarchaeota,23RQ6@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF4352)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4352
HKD1_k127_6001719_10	224325.AF_2002	4.136e-30	123.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,245U8@183980|Archaeoglobi	183980|Archaeoglobi	E	Imidazole acetol-phosphate transaminase	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6001719_8	304371.MCP_1005	6.589e-39	151.0	COG1936@1|root,arCOG01038@2157|Archaea,2XX2A@28890|Euryarchaeota,2N9V1@224756|Methanomicrobia	224756|Methanomicrobia	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
HKD1_k127_6001719_12	387631.Asulf_01672	2.168e-16	92.0	COG2202@1|root,arCOG02330@1|root,arCOG02330@2157|Archaea,arCOG06538@2157|Archaea,2Y14Z@28890|Euryarchaeota,2473B@183980|Archaeoglobi	28890|Euryarchaeota	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_9
HKD1_k127_6001719_6	192952.MM_1739	1.904e-47	175.0	COG1522@1|root,arCOG01628@2157|Archaea,2XUFJ@28890|Euryarchaeota,2N9V6@224756|Methanomicrobia	224756|Methanomicrobia	K	SMART regulatory protein AsnC Lrp family	-	-	-	ko:K22225	-	-	-	-	ko00000	-	-	-	HTH_AsnC-type
HKD1_k127_6001719_7	269797.Mbar_A1461	1.025e-44	171.0	COG1648@1|root,arCOG01044@2157|Archaea,2XWMY@28890|Euryarchaeota,2N9U9@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM siroheme synthase	cysG	GO:0003674,GO:0003824,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0016628,GO:0018130,GO:0019354,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0043115,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046156,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
HKD1_k127_6001719_0	192952.MM_1741	5.229e-141	459.0	COG0373@1|root,arCOG01036@2157|Archaea,2XTTG@28890|Euryarchaeota,2N97X@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD1_k127_6001719_1	693661.Arcve_0503	5.443e-122	398.0	COG0113@1|root,arCOG04300@2157|Archaea,2XSZ8@28890|Euryarchaeota,245ZH@183980|Archaeoglobi	183980|Archaeoglobi	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD1_k127_6001719_9	1365176.N186_01975	5.817e-33	141.0	COG1252@1|root,arCOG01067@2157|Archaea,2XR6I@28889|Crenarchaeota	28889|Crenarchaeota	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6001719_3	269797.Mbar_A3687	8.475e-68	235.0	COG0049@1|root,arCOG04254@2157|Archaea,2XTDC@28890|Euryarchaeota,2N9K7@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center	rps7	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD1_k127_6001719_4	693661.Arcve_1348	8.86e-64	220.0	COG0048@1|root,arCOG04255@2157|Archaea,2XX4A@28890|Euryarchaeota,2465W@183980|Archaeoglobi	183980|Archaeoglobi	J	With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits	rps12	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD1_k127_6001719_5	1094980.Mpsy_1011	5.289e-54	192.0	COG0195@1|root,arCOG01760@2157|Archaea,2XYAY@28890|Euryarchaeota,2N9SC@224756|Methanomicrobia	224756|Methanomicrobia	K	transcription termination protein NusA	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_2
HKD1_k127_6001719_11	387631.Asulf_00700	1.806e-27	114.0	COG1911@1|root,arCOG01752@2157|Archaea,2Y0CU@28890|Euryarchaeota,246FC@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the eukaryotic ribosomal protein eL30 family	rpl30e	-	-	ko:K02908	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
HKD1_k127_6001719_2	1041930.Mtc_2147	2.13e-113	371.0	COG0086@1|root,arCOG04256@2157|Archaea,2XTJ6@28890|Euryarchaeota,2N927@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA2	-	2.7.7.6	ko:K03042	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb1_5
HKD1_k127_6095281_5	1094980.Mpsy_0970	1.18e-27	116.0	COG1412@1|root,arCOG04312@2157|Archaea,2XX55@28890|Euryarchaeota,2N9V2@224756|Methanomicrobia	224756|Methanomicrobia	V	Large family of predicted nucleotide-binding domains	-	-	-	ko:K07158	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_6095281_0	589924.Ferp_1642	2.917e-179	571.0	COG3276@1|root,arCOG01563@2157|Archaea,2XUKU@28890|Euryarchaeota,246W5@183980|Archaeoglobi	183980|Archaeoglobi	J	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA	eif2g	-	-	ko:K03242	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,eIF2_C
HKD1_k127_6095281_1	304371.MCP_1669	2.258e-126	409.0	COG1830@1|root,arCOG04044@2157|Archaea,2XTBQ@28890|Euryarchaeota,2N9E2@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroF	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0920	DeoC
HKD1_k127_6095281_3	1041930.Mtc_1014	1.791e-89	300.0	COG0179@1|root,arCOG00235@2157|Archaea,2XU30@28890|Euryarchaeota,2N9DN@224756|Methanomicrobia	224756|Methanomicrobia	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_6095281_4	351160.LRC391	2.701e-77	267.0	COG0543@1|root,arCOG02199@2157|Archaea,2XSY9@28890|Euryarchaeota,2N98G@224756|Methanomicrobia	224756|Methanomicrobia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD( )	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HKD1_k127_6095281_2	192952.MM_1745	1.343e-101	339.0	COG0167@1|root,arCOG00603@2157|Archaea,2XTMB@28890|Euryarchaeota,2N9ED@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_6095281_6	269797.Mbar_A2625	1.869e-16	85.0	arCOG03459@1|root,arCOG03459@2157|Archaea,2Y5E6@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6095281_7	269797.Mbar_A3616	0.0008562	43.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,2N9X7@224756|Methanomicrobia	224756|Methanomicrobia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD1_k127_6120299_0	1094980.Mpsy_2355	1.705e-85	301.0	COG1287@1|root,arCOG02043@2157|Archaea,2XU8G@28890|Euryarchaeota,2N921@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM Oligosaccharyl transferase STT3 subunit	-	-	2.4.99.18	ko:K07151	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00072	R04216,R05976	RC00005,RC00482	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT66	-	STT3
HKD1_k127_615810_0	266834.SMc01704	1.869e-54	199.0	COG2020@1|root,COG2020@2|Bacteria,1RDC4@1224|Proteobacteria,2TUXA@28211|Alphaproteobacteria,4BNFX@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_615810_3	1345023.M467_15460	1.455e-11	70.0	COG1226@1|root,COG1226@2|Bacteria,1VCJJ@1239|Firmicutes,4HM5T@91061|Bacilli	91061|Bacilli	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_615810_4	1499967.BAYZ01000005_gene5436	1.526e-07	62.0	COG0457@1|root,COG1807@1|root,COG0457@2|Bacteria,COG1807@2|Bacteria,2NQY2@2323|unclassified Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2,TPR_19
HKD1_k127_615810_1	42256.RradSPS_0743	2.646e-43	172.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT_2
HKD1_k127_615810_2	243231.GSU2763	7.367e-42	159.0	COG4420@1|root,COG4420@2|Bacteria,1RIDY@1224|Proteobacteria,42WI7@68525|delta/epsilon subdivisions,2WSAF@28221|Deltaproteobacteria,43VM2@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003
HKD1_k127_6161631_1	269797.Mbar_A0528	1.16e-93	313.0	COG1235@1|root,arCOG00499@2157|Archaea,2XTWY@28890|Euryarchaeota,2N9GT@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM beta-lactamase domain protein	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HKD1_k127_6161631_0	335543.Sfum_2326	7.934e-101	332.0	COG0464@1|root,COG0464@2|Bacteria,1MVVP@1224|Proteobacteria	1224|Proteobacteria	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_6176878_13	551115.Aazo_1651	2.587e-29	119.0	COG0461@1|root,COG0461@2|Bacteria,1G1QB@1117|Cyanobacteria,1HJ84@1161|Nostocales	1117|Cyanobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.umpS	Pribosyltran
HKD1_k127_6176878_5	1094980.Mpsy_3091	8.455e-94	318.0	COG2520@1|root,arCOG10124@2157|Archaea,2XTPV@28890|Euryarchaeota,2N953@224756|Methanomicrobia	224756|Methanomicrobia	J	S-adenosyl-L-methionine-dependent transferase that acts as a component of the wyosine derivatives biosynthesis pathway. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to 4-demethylwyosine (imG-14), forming 7-aminocarboxypropyl-demethylwyosine (wybutosine-86) at position 37 of tRNA(Phe)	taw2	-	2.5.1.114	ko:K07055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Met_10
HKD1_k127_6176878_6	521011.Mpal_1221	4.252e-76	260.0	COG1992@1|root,arCOG00021@2157|Archaea,2Y3P5@28890|Euryarchaeota,2NAWT@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine-phosphate synthase	-	-	2.5.1.3	ko:K21220	ko00730,ko01100,map00730,map01100	-	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	ThiP_synth
HKD1_k127_6176878_3	521011.Mpal_1222	6.521e-135	437.0	COG0309@1|root,arCOG00636@2157|Archaea,2XTAH@28890|Euryarchaeota	28890|Euryarchaeota	O	AIR synthase related protein domain protein	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_6176878_8	593750.Metfor_2454	3.043e-70	246.0	COG1606@1|root,arCOG00043@2157|Archaea,2XV2X@28890|Euryarchaeota,2N9N2@224756|Methanomicrobia	224756|Methanomicrobia	S	PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase,QueC
HKD1_k127_6176878_1	1094980.Mpsy_1021	3.789e-142	461.0	COG0520@1|root,arCOG00065@2157|Archaea,2XSYI@28890|Euryarchaeota,2NAI4@224756|Methanomicrobia	224756|Methanomicrobia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5,PAPS_reduct
HKD1_k127_6176878_7	521011.Mpal_1216	1.94e-71	248.0	COG1526@1|root,arCOG04358@2157|Archaea,2XYNI@28890|Euryarchaeota,2NAIN@224756|Methanomicrobia	224756|Methanomicrobia	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD1_k127_6176878_4	1094980.Mpsy_1017	8.675e-120	390.0	COG0379@1|root,arCOG04459@2157|Archaea,2XUGT@28890|Euryarchaeota,2NABJ@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	-	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD1_k127_6176878_15	986075.CathTA2_2920	1.254e-10	65.0	COG1977@1|root,COG1977@2|Bacteria,1VGMS@1239|Firmicutes,4HQTZ@91061|Bacilli	91061|Bacilli	H	COG1977 Molybdopterin converting factor, small subunit	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_6176878_11	386456.JQKN01000001_gene2143	7.615e-44	168.0	COG3482@1|root,arCOG05002@2157|Archaea,2XXHR@28890|Euryarchaeota,23P0X@183925|Methanobacteria	183925|Methanobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
HKD1_k127_6176878_0	368407.Memar_1333	3.48e-155	499.0	COG1944@1|root,arCOG02882@2157|Archaea,2XUE0@28890|Euryarchaeota,2N9AP@224756|Methanomicrobia	224756|Methanomicrobia	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
HKD1_k127_6176878_12	335543.Sfum_0232	1.431e-36	142.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,42U19@68525|delta/epsilon subdivisions,2WR05@28221|Deltaproteobacteria,2MQJB@213462|Syntrophobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD1_k127_6176878_14	351160.RRC414	1.388e-13	76.0	arCOG04993@1|root,arCOG04993@2157|Archaea,2Y0MZ@28890|Euryarchaeota,2NA0K@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176878_2	192952.MM_2368	1.018e-135	441.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,2N9E9@224756|Methanomicrobia	224756|Methanomicrobia	E	aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6176878_10	1094980.Mpsy_1579	1.019e-45	168.0	COG0231@1|root,arCOG04277@2157|Archaea,2XX3E@28890|Euryarchaeota,2N9R5@224756|Methanomicrobia	224756|Methanomicrobia	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	EFP_N,eIF-5a
HKD1_k127_6176878_9	1094980.Mpsy_0048	1.914e-63	224.0	COG0165@1|root,arCOG01748@2157|Archaea,2XUWS@28890|Euryarchaeota,2N9AC@224756|Methanomicrobia	224756|Methanomicrobia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_6243985_4	368407.Memar_1816	1.928e-24	115.0	COG0142@1|root,arCOG01726@2157|Archaea,2XTAC@28890|Euryarchaeota,2N97R@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_6243985_2	192952.MM_2012	6.826e-63	221.0	COG1094@1|root,arCOG04150@2157|Archaea,2XUHX@28890|Euryarchaeota,2N9JJ@224756|Methanomicrobia	224756|Methanomicrobia	J	KH domain protein	-	-	-	ko:K06961	-	-	-	-	ko00000,ko03009	-	-	-	KH_1
HKD1_k127_6243985_1	1094980.Mpsy_1474	1.403e-75	263.0	COG1718@1|root,arCOG01180@2157|Archaea,2XU2H@28890|Euryarchaeota,2N9ET@224756|Methanomicrobia	224756|Methanomicrobia	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
HKD1_k127_6243985_3	1041930.Mtc_1253	8.242e-41	153.0	COG0361@1|root,arCOG01179@2157|Archaea,2XXX0@28890|Euryarchaeota,2NA1A@224756|Methanomicrobia	224756|Methanomicrobia	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
HKD1_k127_6243985_0	1094980.Mpsy_1109	1.325e-84	287.0	COG0020@1|root,arCOG01532@2157|Archaea,2XSW1@28890|Euryarchaeota,2N9C9@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
HKD1_k127_6244301_3	1521187.JPIM01000172_gene3327	1.377e-31	128.0	COG3415@1|root,COG3415@2|Bacteria,2G9BT@200795|Chloroflexi,3778B@32061|Chloroflexia	32061|Chloroflexia	L	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6244301_1	247490.KSU1_D0773	1.037e-100	333.0	COG3335@1|root,COG3335@2|Bacteria,2IZSH@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_6244301_5	1035308.AQYY01000001_gene1487	9.159e-08	60.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	HCBP_related,HemolysinCabind
HKD1_k127_6244301_2	192952.MM_1823	1.502e-51	188.0	COG2426@1|root,arCOG01330@2157|Archaea,2XZ2Y@28890|Euryarchaeota,2NAQX@224756|Methanomicrobia	224756|Methanomicrobia	S	Putative small multi-drug export protein	-	-	-	-	-	-	-	-	-	-	-	-	Sm_multidrug_ex
HKD1_k127_6244301_0	351160.RCIX1971	2.572e-238	747.0	COG0459@1|root,arCOG01257@2157|Archaea,2XUDQ@28890|Euryarchaeota,2N9DC@224756|Methanomicrobia	224756|Methanomicrobia	O	PFAM chaperonin Cpn60 TCP-1	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_6244301_4	192952.MM_2259	1.69e-18	88.0	COG2923@1|root,arCOG02069@2157|Archaea	2157|Archaea	P	protein involved in the oxidation of intracellular sulfur	-	-	-	ko:K07236	ko04122,map04122	-	-	-	ko00000,ko00001,ko03016	-	-	-	DrsE
HKD1_k127_6248333_2	456442.Mboo_0501	2.686e-49	183.0	COG0621@1|root,arCOG01358@2157|Archaea,2XSVB@28890|Euryarchaeota,2N9GQ@224756|Methanomicrobia	224756|Methanomicrobia	J	SMART Elongator protein 3 MiaB NifB	miaB	-	2.8.4.5	ko:K15865	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_6248333_1	269797.Mbar_A2944	1.002e-68	245.0	COG0628@1|root,arCOG02642@2157|Archaea,2XXF0@28890|Euryarchaeota,2N9N3@224756|Methanomicrobia	224756|Methanomicrobia	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_6248333_0	269797.Mbar_A0178	6.059e-96	325.0	COG2038@1|root,arCOG04272@2157|Archaea,2XTPU@28890|Euryarchaeota,2N9K1@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6255017_2	1121904.ARBP01000008_gene3435	4.046e-09	67.0	COG1357@1|root,COG1357@2|Bacteria,4NR89@976|Bacteroidetes,47QHC@768503|Cytophagia	976|Bacteroidetes	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide_3
HKD1_k127_6255017_0	521011.Mpal_1981	6.061e-67	233.0	COG0652@1|root,arCOG04767@2157|Archaea,2XTHC@28890|Euryarchaeota,2N9X7@224756|Methanomicrobia	224756|Methanomicrobia	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD1_k127_6255017_1	386456.JQKN01000017_gene841	7.607e-13	68.0	arCOG12322@1|root,arCOG12322@2157|Archaea,2Y5I1@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6276068_0	653733.Selin_0596	3.832e-138	478.0	COG0591@1|root,COG2203@1|root,COG2208@1|root,COG0591@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K01079,ko:K07315	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03021	-	-	-	FHA,GAF,GAF_2,HATPase_c,HisKA,SpoIIE
HKD1_k127_6278239_0	1267535.KB906767_gene3664	1.021e-36	157.0	COG4993@1|root,COG4993@2|Bacteria,3Y696@57723|Acidobacteria	57723|Acidobacteria	G	PQQ-like domain	-	-	1.1.2.8	ko:K00114	ko00010,ko00625,ko01100,ko01110,ko01120,ko01130,map00010,map00625,map01100,map01110,map01120,map01130	-	R05062,R05198,R05285	RC00087,RC00088,RC01039	ko00000,ko00001,ko01000	-	-	-	PQQ_2
HKD1_k127_6278239_1	521011.Mpal_0675	5.405e-26	112.0	COG2133@1|root,arCOG03441@1|root,arCOG02796@2157|Archaea,arCOG03441@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
HKD1_k127_6303676_1	304371.MCP_1516	4.533e-122	406.0	COG0343@1|root,COG1549@1|root,arCOG00989@2157|Archaea,arCOG00990@2157|Archaea,2XT9W@28890|Euryarchaeota,2N990@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM PUA domain containing protein	-	-	2.6.1.97	ko:K07557	-	-	-	-	ko00000,ko01000	-	-	-	PUA,TGT,TGT_C2
HKD1_k127_6303676_2	390874.Tpet_0564	4.35e-105	355.0	COG1171@1|root,COG1171@2|Bacteria	2|Bacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	iLJ478.TM0356	ACT,ACT_4,PALP
HKD1_k127_6303676_0	1041930.Mtc_0022	3.535e-151	499.0	COG1293@1|root,arCOG01695@2157|Archaea,2XTMF@28890|Euryarchaeota,2N97T@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_6314381_1	234267.Acid_1647	1.62e-06	55.0	COG1596@1|root,COG1596@2|Bacteria,3Y51C@57723|Acidobacteria	57723|Acidobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_6314381_0	410359.Pcal_2030	6.546e-11	70.0	COG1525@1|root,arCOG03193@2157|Archaea	2157|Archaea	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6337279_0	386456.JQKN01000011_gene777	1.582e-209	662.0	arCOG02763@1|root,arCOG02763@2157|Archaea,2Y8CF@28890|Euryarchaeota,23PZN@183925|Methanobacteria	183925|Methanobacteria	P	E1-E2 ATPase	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_6337279_2	593750.Metfor_1237	1.259e-18	85.0	COG3350@1|root,arCOG04507@2157|Archaea	2157|Archaea	P	PFAM YHS domain	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,Hydrolase,YHS
HKD1_k127_6337279_1	304371.MCP_0970	1.571e-169	545.0	COG1249@1|root,arCOG01068@2157|Archaea,2XTJE@28890|Euryarchaeota,2N9NV@224756|Methanomicrobia	224756|Methanomicrobia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_6377806_3	351160.RCIX1512	5.021e-43	165.0	COG0169@1|root,arCOG02097@2157|Archaea,2XWH4@28890|Euryarchaeota,2N9XM@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
HKD1_k127_6377806_1	1094980.Mpsy_1419	6.823e-135	439.0	COG1465@1|root,arCOG04353@2157|Archaea,2XSXD@28890|Euryarchaeota,2N9AV@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
HKD1_k127_6377806_2	192952.MM_1817	8.157e-68	237.0	COG4089@1|root,arCOG02159@2157|Archaea,2XY93@28890|Euryarchaeota,2N9R2@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
HKD1_k127_6377806_0	304371.MCP_1907	1.403e-143	468.0	COG0043@1|root,arCOG01671@2157|Archaea,2XUDW@28890|Euryarchaeota,2N95C@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM UbiD family	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HKD1_k127_6396565_1	203124.Tery_0500	4.844e-15	76.0	COG0668@1|root,COG4447@1|root,COG0668@2|Bacteria,COG4447@2|Bacteria,1G0ZM@1117|Cyanobacteria,1H7Z7@1150|Oscillatoriales	1117|Cyanobacteria	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HKD1_k127_6396565_0	479434.Sthe_2774	4.233e-131	439.0	28HJF@1|root,2Z7UK@2|Bacteria,2G862@200795|Chloroflexi	200795|Chloroflexi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6411619_5	448385.sce2381	2.641e-06	51.0	COG0262@1|root,COG0262@2|Bacteria,1R7YJ@1224|Proteobacteria,42ZF9@68525|delta/epsilon subdivisions,2WUSX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_6411619_4	521011.Mpal_1970	5.386e-08	62.0	COG3291@1|root,arCOG02498@1|root,arCOG02526@1|root,arCOG02498@2157|Archaea,arCOG02510@2157|Archaea,arCOG02526@2157|Archaea,2Y30D@28890|Euryarchaeota,2NAGI@224756|Methanomicrobia	224756|Methanomicrobia	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	NosD,PKD
HKD1_k127_6411619_1	1123228.AUIH01000017_gene3646	4.668e-52	191.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,1RMFX@1236|Gammaproteobacteria,1XI3J@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
HKD1_k127_6411619_0	706587.Desti_2994	3.373e-111	370.0	COG1063@1|root,COG1063@2|Bacteria,1MW7C@1224|Proteobacteria,430WX@68525|delta/epsilon subdivisions,2WW1H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N
HKD1_k127_6411619_2	926550.CLDAP_31610	1.226e-47	174.0	COG0720@1|root,COG0720@2|Bacteria,2G7B6@200795|Chloroflexi	200795|Chloroflexi	H	PFAM 6-pyruvoyl tetrahydropterin synthase and	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_6411619_3	706587.Desti_2992	3.015e-47	176.0	COG0438@1|root,COG0438@2|Bacteria,1P81Z@1224|Proteobacteria	1224|Proteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_6417154_1	572546.Arcpr_0020	7.593e-99	329.0	COG0107@1|root,arCOG00617@2157|Archaea,2XU22@28890|Euryarchaeota,246PF@183980|Archaeoglobi	183980|Archaeoglobi	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_6417154_0	192952.MM_2611	5.252e-185	588.0	COG2509@1|root,arCOG02231@2157|Archaea,2XTVH@28890|Euryarchaeota,2N9BS@224756|Methanomicrobia	224756|Methanomicrobia	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2
HKD1_k127_6417154_4	5888.CAK66192	2.917e-43	167.0	COG3914@1|root,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_6417154_6	192952.MM_2950	3.841e-20	94.0	arCOG04419@1|root,arCOG04419@2157|Archaea,2XZTP@28890|Euryarchaeota,2N9ZJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2551)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2551
HKD1_k127_6417154_2	1094980.Mpsy_0219	7.846e-51	183.0	arCOG04388@1|root,arCOG04388@2157|Archaea,2XY88@28890|Euryarchaeota,2NAQF@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6417154_3	192952.MM_0692	3.628e-44	166.0	COG1675@1|root,arCOG04270@2157|Archaea,2XSWK@28890|Euryarchaeota,2N9WY@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
HKD1_k127_6417154_5	1041930.Mtc_0771	1.214e-26	114.0	COG4738@1|root,arCOG04377@2157|Archaea,2XYIC@28890|Euryarchaeota,2NBJG@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator, TrmB	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6426907_8	76114.ebA5690	3.989e-06	49.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1N5WI@1224|Proteobacteria,2VHUB@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD1_k127_6426907_7	456442.Mboo_1487	2.238e-06	51.0	COG0642@1|root,arCOG02352@1|root,arCOG02352@2157|Archaea,arCOG06192@2157|Archaea	2157|Archaea	T	TIGRFAM PAS sensor protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA_2,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_6426907_3	697282.Mettu_2058	4.051e-16	81.0	COG2203@1|root,COG5001@1|root,COG2203@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1XDYH@135618|Methylococcales	135618|Methylococcales	T	Diguanylate cyclase phosphodiesterase with PAS PAC	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF
HKD1_k127_6426907_6	521011.Mpal_2464	7.406e-07	60.0	COG3413@1|root,arCOG02385@1|root,arCOG06712@1|root,arCOG02276@2157|Archaea,arCOG02385@2157|Archaea,arCOG06712@2157|Archaea	2157|Archaea	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,HisKA_2,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_6426907_1	351160.RRC193	9.81e-43	167.0	COG0642@1|root,COG2202@1|root,arCOG06192@2157|Archaea,arCOG06515@2157|Archaea,arCOG06918@2157|Archaea	2157|Archaea	T	Pas domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_6426907_0	247490.KSU1_D0867	4.796e-75	258.0	COG2203@1|root,COG3829@1|root,COG4251@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,COG4251@2|Bacteria,2J2DQ@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,dCache_1
HKD1_k127_6426907_2	1121918.ARWE01000001_gene3201	2.906e-36	139.0	COG0745@1|root,COG4191@1|root,COG0745@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,43BT2@68525|delta/epsilon subdivisions,2WM4H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,Response_reg
HKD1_k127_6426907_4	304371.MCP_1444	7.741e-11	65.0	COG2201@1|root,COG2202@1|root,arCOG04921@2157|Archaea,arCOG06918@2157|Archaea,2Y7RM@28890|Euryarchaeota,2N9F6@224756|Methanomicrobia	224756|Methanomicrobia	N	PAS domain	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS,PAS_10,PAS_4
HKD1_k127_6426907_5	937777.Deipe_3173	1.599e-07	55.0	COG1352@1|root,COG2201@1|root,COG1352@2|Bacteria,COG2201@2|Bacteria	2|Bacteria	NT	protein-glutamate methylesterase activity	cheBR	-	2.1.1.80,3.1.1.61,3.5.1.44	ko:K00575,ko:K03412,ko:K03413,ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,PAS,PAS_10,PAS_4,PAS_9,Response_reg
HKD1_k127_6432977_0	635013.TherJR_0525	1.393e-268	839.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_645955_1	1041930.Mtc_1254	1.502e-33	132.0	COG0162@1|root,arCOG01886@2157|Archaea,2XTA0@28890|Euryarchaeota,2N98T@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
HKD1_k127_645955_3	1120956.JHZK01000026_gene764	3.622e-07	52.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2U70V@28211|Alphaproteobacteria,1JP31@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD1_k127_645955_2	633148.Tagg_1266	3.305e-24	113.0	COG4353@1|root,arCOG01699@2157|Archaea,2XR1F@28889|Crenarchaeota	28889|Crenarchaeota	S	uncharacterised conserved protein UCP017998	-	-	-	-	-	-	-	-	-	-	-	-	DUF1122
HKD1_k127_645955_0	593750.Metfor_0199	6.409e-43	161.0	COG1661@1|root,arCOG04212@2157|Archaea,2XZVT@28890|Euryarchaeota	28890|Euryarchaeota	S	Domain of unknown function (DUF296)	-	-	-	ko:K06934	-	-	-	-	ko00000	-	-	-	DUF296
HKD1_k127_645955_4	1319815.HMPREF0202_01684	5.465e-05	50.0	COG4974@1|root,COG4974@2|Bacteria,379Q6@32066|Fusobacteria	32066|Fusobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_6468383_8	192952.MM_0669	8.904e-59	207.0	COG0440@1|root,arCOG04445@2157|Archaea,2XVFX@28890|Euryarchaeota,2N9NK@224756|Methanomicrobia	224756|Methanomicrobia	E	Acetolactate synthase, small subunit	ilvN	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD1_k127_6468383_1	351160.LRC519	6.216e-141	454.0	COG0059@1|root,arCOG04465@2157|Archaea,2XTGU@28890|Euryarchaeota,2N98K@224756|Methanomicrobia	224756|Methanomicrobia	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD1_k127_6468383_5	192952.MM_1365	3.811e-82	283.0	COG0611@1|root,arCOG00638@2157|Archaea,2XSUK@28890|Euryarchaeota,2N9G5@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_6468383_7	1094980.Mpsy_2609	3.082e-62	224.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT8Z@28890|Euryarchaeota,2NA1D@224756|Methanomicrobia	224756|Methanomicrobia	H	RimK domain protein ATP-grasp	-	-	6.3.2.33	ko:K05844,ko:K15740	ko00790,map00790	-	R09594	RC00064,RC00141	ko00000,ko00001,ko01000,ko03009	-	-	-	RimK
HKD1_k127_6468383_2	365659.smi_0022	1.448e-132	435.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,4H9YT@91061|Bacilli,2TPEN@28037|Streptococcus mitis	91061|Bacilli	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	GO:0003674,GO:0003824,GO:0004019,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006167,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044208,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046033,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_6468383_6	1041930.Mtc_0658	2.693e-67	236.0	COG1693@1|root,arCOG02711@2157|Archaea,2XUUJ@28890|Euryarchaeota,2N94A@224756|Methanomicrobia	224756|Methanomicrobia	K	Domain of unknown function DUF128	-	-	-	ko:K21640	-	-	-	-	ko00000	-	-	-	DUF128
HKD1_k127_6468383_4	192952.MM_2077	8.166e-87	292.0	COG1458@1|root,arCOG00720@2157|Archaea,2XUK7@28890|Euryarchaeota,2NAIW@224756|Methanomicrobia	224756|Methanomicrobia	V	PINc domain ribonuclease	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	PIN_5
HKD1_k127_6468383_3	521011.Mpal_1283	8.244e-97	323.0	COG1659@1|root,arCOG05909@2157|Archaea,2Y7FS@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM Linocin_M18 bacteriocin protein	-	-	-	-	-	-	-	-	-	-	-	-	Linocin_M18
HKD1_k127_6468383_10	593750.Metfor_2787	7.688e-42	156.0	COG1633@1|root,arCOG03349@2157|Archaea	2157|Archaea	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_6468383_11	386456.JQKN01000001_gene2253	1.406e-08	63.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_6468383_9	1041930.Mtc_0275	1.526e-56	203.0	COG0218@1|root,arCOG00355@2157|Archaea,2XTV8@28890|Euryarchaeota,2N9M7@224756|Methanomicrobia	224756|Methanomicrobia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
HKD1_k127_6468383_0	1041930.Mtc_0246	5.2e-153	495.0	COG1222@1|root,arCOG01306@2157|Archaea,2XTB6@28890|Euryarchaeota,2N947@224756|Methanomicrobia	224756|Methanomicrobia	O	TIGRFAM 26S proteasome subunit P45 family	pan-1	-	-	ko:K03420	ko03050,map03050	M00343	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
HKD1_k127_6502912_0	1094980.Mpsy_1319	8.63e-103	344.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_6508518_3	1305737.JAFX01000001_gene2781	4.507e-28	119.0	COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,47MZ0@768503|Cytophagia	976|Bacteroidetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD1_k127_6508518_0	1040987.AZUY01000005_gene2085	3.918e-113	375.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,43IWV@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	PFAM Pyridoxal-dependent decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD1_k127_6508518_1	391623.TERMP_00349	3.798e-60	211.0	COG1225@1|root,arCOG00310@2157|Archaea,2XY0E@28890|Euryarchaeota,2440M@183968|Thermococci	183968|Thermococci	O	SCO1/SenC	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_6508518_2	562970.Btus_2357	5.433e-30	123.0	COG0501@1|root,COG0501@2|Bacteria,1TP23@1239|Firmicutes,4HB11@91061|Bacilli,2782X@186823|Alicyclobacillaceae	91061|Bacilli	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_6516729_8	1094980.Mpsy_2047	3.844e-16	78.0	COG0147@1|root,arCOG02014@2157|Archaea,2XU5J@28890|Euryarchaeota,2N9A9@224756|Methanomicrobia	224756|Methanomicrobia	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_6516729_5	269797.Mbar_A3627	5.641e-60	213.0	COG0512@1|root,arCOG00086@2157|Archaea,2XV6H@28890|Euryarchaeota,2NBHQ@224756|Methanomicrobia	224756|Methanomicrobia	E	Peptidase C26	-	-	4.1.3.27	ko:K01658	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3627	GATase
HKD1_k127_6516729_7	309800.C498_14798	1.166e-44	173.0	COG0134@1|root,arCOG01088@2157|Archaea,2XTWK@28890|Euryarchaeota,23T59@183963|Halobacteria	183963|Halobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD1_k127_6516729_2	1094980.Mpsy_0856	3.048e-147	488.0	COG2433@1|root,arCOG04219@2157|Archaea,2XT3D@28890|Euryarchaeota,2N92G@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF460)	-	-	-	ko:K09150	-	-	-	-	ko00000	-	-	-	DUF460
HKD1_k127_6516729_0	1304880.JAGB01000002_gene1980	7.444e-183	579.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_6516729_4	246969.TAM4_860	1.131e-64	238.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,243QQ@183968|Thermococci	183968|Thermococci	M	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD1_k127_6516729_6	1104324.P186_2163	1.52e-46	173.0	COG1573@1|root,arCOG00905@2157|Archaea,2XQ7T@28889|Crenarchaeota	28889|Crenarchaeota	L	TIGRFAM phage SPO1 DNA polymerase-related protein	-	GO:0003674,GO:0003824,GO:0004844,GO:0005488,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0048037,GO:0050896,GO:0051536,GO:0051539,GO:0051540,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_6516729_3	192952.MM_0675	3.105e-79	275.0	COG0618@1|root,arCOG01565@2157|Archaea,2XWQV@28890|Euryarchaeota,2N9IY@224756|Methanomicrobia	224756|Methanomicrobia	S	DHH family	-	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
HKD1_k127_6516729_1	269797.Mbar_A3562	2.822e-165	529.0	COG0126@1|root,arCOG00496@2157|Archaea,2XSXX@28890|Euryarchaeota,2N98M@224756|Methanomicrobia	224756|Methanomicrobia	G	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_6534350_0	1094980.Mpsy_1319	3.957e-103	343.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_653641_2	102129.Lepto7375DRAFT_0842	0.0001542	50.0	COG1572@1|root,COG3209@1|root,COG1572@2|Bacteria,COG3209@2|Bacteria,1G4UG@1117|Cyanobacteria,1HH6U@1150|Oscillatoriales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
HKD1_k127_653641_1	386456.JQKN01000014_gene3151	1.628e-07	60.0	COG4880@1|root,arCOG03545@2157|Archaea	2157|Archaea	L	Chagasin family peptidase inhibitor I42	-	-	-	ko:K14475	ko05143,map05143	-	-	-	ko00000,ko00001	-	-	-	Beta_propel,Inhibitor_I42
HKD1_k127_653641_0	443254.Marpi_1007	7.525e-38	159.0	COG1520@1|root,COG1520@2|Bacteria,2GD9T@200918|Thermotogae	200918|Thermotogae	S	PFAM Fibronectin type III domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6552885_5	444158.MmarC6_1034	7.043e-13	73.0	COG2043@1|root,arCOG02289@2157|Archaea,2XXJQ@28890|Euryarchaeota,23Q76@183939|Methanococci	183939|Methanococci	S	Uncharacterised ArCR, COG2043	-	-	-	-	-	-	-	-	-	-	-	-	DUF169
HKD1_k127_6552885_3	269797.Mbar_A1187	8.028e-22	96.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N95E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-2	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_6552885_0	192952.MM_1394	2.427e-125	410.0	COG1797@1|root,arCOG00106@2157|Archaea,2XTIE@28890|Euryarchaeota,2N95E@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni- sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source	cbiA-2	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_6552885_2	1094980.Mpsy_1300	6.43e-67	237.0	COG1810@1|root,arCOG02469@2157|Archaea,2XXEB@28890|Euryarchaeota,2NA3C@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	DUF166
HKD1_k127_6552885_1	1094980.Mpsy_0837	2.721e-81	279.0	COG1951@1|root,arCOG04407@2157|Archaea,2XUQI@28890|Euryarchaeota,2N9FT@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S type, tartrate fumarate subfamily, alpha	fumA	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD1_k127_6552885_4	529709.PYCH_06710	6.194e-21	94.0	COG1838@1|root,arCOG04406@2157|Archaea,2XXBQ@28890|Euryarchaeota,24417@183968|Thermococci	183968|Thermococci	C	Fumarase C-terminus	-	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
HKD1_k127_6555014_1	1270196.JCKI01000003_gene1875	2.187e-23	108.0	COG0671@1|root,COG0671@2|Bacteria,4NI23@976|Bacteroidetes	976|Bacteroidetes	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_6555014_2	593750.Metfor_2246	1.864e-19	94.0	COG0417@1|root,arCOG07763@1|root,arCOG00329@2157|Archaea,arCOG07763@2157|Archaea,2XUJB@28890|Euryarchaeota	28890|Euryarchaeota	L	DNA polymerase elongation subunit (Family B)	polB2	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B
HKD1_k127_6555014_0	395961.Cyan7425_0454	8.859e-78	263.0	COG3153@1|root,COG3153@2|Bacteria,1GK4X@1117|Cyanobacteria,3KIFY@43988|Cyanothece	1117|Cyanobacteria	S	PFAM GCN5-related N-acetyltransferase	-	-	-	ko:K03824	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_9
HKD1_k127_6555014_3	593750.Metfor_1254	1.319e-07	53.0	COG1738@1|root,arCOG04284@2157|Archaea	2157|Archaea	U	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HKD1_k127_6568179_1	679926.Mpet_1911	0.0008326	44.0	COG0599@1|root,arCOG02148@2157|Archaea,2Y12T@28890|Euryarchaeota,2N9VC@224756|Methanomicrobia	224756|Methanomicrobia	S	TIGRFAM alkylhydroperoxidase like protein, AhpD family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_6568179_0	1220534.B655_1262	1.378e-47	173.0	COG0599@1|root,arCOG02148@2157|Archaea,2XYN2@28890|Euryarchaeota,23PPS@183925|Methanobacteria	183925|Methanobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_6582522_1	387631.Asulf_02074	1.029e-62	220.0	COG0004@1|root,arCOG04397@2157|Archaea,2XTEB@28890|Euryarchaeota	28890|Euryarchaeota	P	Ammonium Transporter	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_6582522_2	523845.AQXV01000040_gene1700	1.307e-36	141.0	COG0347@1|root,arCOG02305@2157|Archaea,2XYN5@28890|Euryarchaeota,23R3U@183939|Methanococci	183939|Methanococci	E	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_6582522_0	632335.Calkr_0531	1.698e-63	220.0	COG2070@1|root,COG2070@2|Bacteria,1UJNK@1239|Firmicutes,25F6P@186801|Clostridia,42J79@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM ferredoxin-dependent glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Glu_synthase
HKD1_k127_6582866_3	351160.RCIX2580	6.11e-51	186.0	COG0099@1|root,arCOG01722@2157|Archaea,2XWHE@28890|Euryarchaeota,2N9RA@224756|Methanomicrobia	224756|Methanomicrobia	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_6582866_2	1094980.Mpsy_1113	2.428e-52	191.0	COG0522@1|root,arCOG04239@2157|Archaea,2XXYX@28890|Euryarchaeota,2N9QT@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD1_k127_6582866_1	565033.GACE_0208	1.129e-62	216.0	COG0100@1|root,arCOG04240@2157|Archaea,2XX1S@28890|Euryarchaeota,24666@183980|Archaeoglobi	183980|Archaeoglobi	J	Located on the platform of the 30S subunit	rps11	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD1_k127_6582866_0	1094980.Mpsy_1111	2.292e-67	237.0	COG0202@1|root,arCOG04241@2157|Archaea,2XTQB@28890|Euryarchaeota,2N911@224756|Methanomicrobia	224756|Methanomicrobia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoD	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	Fer4,Fer4_9,RNA_pol_A_bac,RNA_pol_L
HKD1_k127_6582866_6	1121346.KB899853_gene137	3.042e-05	50.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HD6Z@91061|Bacilli,26SPH@186822|Paenibacillaceae	91061|Bacilli	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase
HKD1_k127_6582866_4	1122216.AUHW01000007_gene1481	7.31e-06	51.0	COG4974@1|root,COG4974@2|Bacteria,1V98H@1239|Firmicutes,4H45S@909932|Negativicutes	909932|Negativicutes	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
HKD1_k127_6582866_5	877411.JMMA01000002_gene1659	2.133e-05	50.0	COG3857@1|root,COG3857@2|Bacteria,1TS95@1239|Firmicutes,24F8M@186801|Clostridia,3WMMM@541000|Ruminococcaceae	186801|Clostridia	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
HKD1_k127_6599521_0	192952.MM_0093	5.063e-178	570.0	COG1492@1|root,arCOG00105@2157|Archaea,2XT04@28890|Euryarchaeota,2N93Y@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_6623604_2	198467.NP92_06205	1.938e-31	125.0	COG1715@1|root,COG1715@2|Bacteria,1V1TA@1239|Firmicutes,4HC3T@91061|Bacilli	91061|Bacilli	L	restriction endonuclease	mrr2	-	-	ko:K07448	-	-	-	-	ko00000,ko02048	-	-	-	MerR_1,Mrr_N,Mrr_cat
HKD1_k127_6623604_1	387631.Asulf_01342	2.383e-52	191.0	COG0595@1|root,arCOG00547@2157|Archaea,2XTIB@28890|Euryarchaeota,246UA@183980|Archaeoglobi	183980|Archaeoglobi	J	PFAM RNA-metabolising metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	-
HKD1_k127_6623604_3	573370.DMR_00970	2.616e-08	59.0	2EGUV@1|root,33AM0@2|Bacteria,1P8EU@1224|Proteobacteria,432CW@68525|delta/epsilon subdivisions,2WXMZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6679202_0	269797.Mbar_A2945	2.932e-199	627.0	COG0441@1|root,arCOG00401@2157|Archaea,2XTFI@28890|Euryarchaeota,2N9FW@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	GO:0002161,GO:0003674,GO:0003824,GO:0004812,GO:0004829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006435,GO:0006450,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0046483,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b,tRNA_SAD
HKD1_k127_6685599_0	604354.TSIB_0718	6.397e-91	306.0	COG0477@1|root,arCOG00143@2157|Archaea,2Y8EH@28890|Euryarchaeota,245MX@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6685599_3	387631.Asulf_02173	5.776e-10	61.0	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_6685599_2	269797.Mbar_A2247	4.616e-15	76.0	COG0582@1|root,arCOG01241@2157|Archaea,2XV3E@28890|Euryarchaeota,2NA4B@224756|Methanomicrobia	224756|Methanomicrobia	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerA	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_integrase
HKD1_k127_6685599_1	290317.Cpha266_1157	1.785e-33	133.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31,Ubie_methyltran
HKD1_k127_6730296_8	456442.Mboo_0643	6.331e-43	179.0	COG2208@1|root,arCOG02362@1|root,arCOG02362@2157|Archaea,arCOG06893@2157|Archaea	2157|Archaea	KT	stage II sporulation	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE,dCache_1
HKD1_k127_6730296_9	192952.MM_0371	3.134e-15	85.0	arCOG03321@1|root,arCOG03321@2157|Archaea,2Y3WV@28890|Euryarchaeota,2NATQ@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6730296_3	1094980.Mpsy_0115	1.564e-126	413.0	COG0714@1|root,arCOG00434@2157|Archaea,2XSZU@28890|Euryarchaeota,2NA7N@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM ATPase associated with various cellular activities, AAA_3	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_6730296_5	1094980.Mpsy_0116	3.092e-80	276.0	COG1721@1|root,arCOG02745@2157|Archaea,2XVGA@28890|Euryarchaeota,2NAC9@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_6730296_4	269797.Mbar_A3720	2.399e-111	372.0	COG3875@1|root,arCOG02046@2157|Archaea,2XVDD@28890|Euryarchaeota,2N9Q8@224756|Methanomicrobia	224756|Methanomicrobia	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_6730296_1	386456.JQKN01000024_gene576	3.458e-202	639.0	COG1014@1|root,arCOG01600@2157|Archaea,2XV2P@28890|Euryarchaeota,23PAT@183925|Methanobacteria	183925|Methanobacteria	C	Thiamine pyrophosphate enzyme, C-terminal	-	-	1.2.7.7	ko:K00187	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	POR,TPP_enzyme_C
HKD1_k127_6730296_2	386456.JQKN01000024_gene577	6.385e-160	510.0	COG0674@1|root,arCOG01607@2157|Archaea,2XW4W@28890|Euryarchaeota,23PE7@183925|Methanobacteria	183925|Methanobacteria	C	ferredoxin oxidoreductase	-	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_6730296_0	192952.MM_3180	3.598e-264	827.0	COG0365@1|root,arCOG04201@2157|Archaea,2XSTQ@28890|Euryarchaeota,2N9F4@224756|Methanomicrobia	224756|Methanomicrobia	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C,HTH_17
HKD1_k127_6730296_6	1220534.B655_0396	1.344e-62	221.0	COG1396@1|root,arCOG01866@2157|Archaea,2XTT6@28890|Euryarchaeota,23NZK@183925|Methanobacteria	183925|Methanobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3
HKD1_k127_6730296_7	269797.Mbar_A2941	1.298e-48	182.0	COG0457@1|root,arCOG06750@1|root,arCOG03032@2157|Archaea,arCOG06750@2157|Archaea,2Y7M7@28890|Euryarchaeota	28890|Euryarchaeota	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
HKD1_k127_6731733_0	43989.cce_4525	4.069e-53	192.0	COG2340@1|root,COG2340@2|Bacteria,1G6MJ@1117|Cyanobacteria,3KHND@43988|Cyanothece	1117|Cyanobacteria	S	SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD1_k127_6731733_1	1220534.B655_1409	2.661e-46	180.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
HKD1_k127_6731733_2	1056495.Calag_1293	3.356e-06	49.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_6732897_3	1279009.ADICEAN_03497	1.001e-20	102.0	COG4974@1|root,COG4974@2|Bacteria,4NGE1@976|Bacteroidetes,47KKB@768503|Cytophagia	976|Bacteroidetes	L	Belongs to the 'phage' integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_6732897_0	387631.Asulf_02173	1.44e-97	327.0	COG0582@1|root,arCOG01241@2157|Archaea,2XUBA@28890|Euryarchaeota	28890|Euryarchaeota	L	integrase family	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_6732897_1	521011.Mpal_0788	1.076e-59	212.0	COG1704@1|root,arCOG04574@2157|Archaea,2XX6E@28890|Euryarchaeota,2N9YK@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_6732897_4	456442.Mboo_2446	3.174e-17	87.0	COG4907@1|root,arCOG03432@2157|Archaea,2XVA0@28890|Euryarchaeota,2NA0A@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HKD1_k127_6854739_0	1457250.BBMO01000001_gene415	2.137e-06	51.0	arCOG08018@1|root,arCOG08018@2157|Archaea,2Y083@28890|Euryarchaeota,23XN7@183963|Halobacteria	183963|Halobacteria	S	Protein of unknown function (DUF1328)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD1_k127_6860568_1	1265505.ATUG01000001_gene4047	1.275e-05	47.0	COG0589@1|root,COG0589@2|Bacteria,1N9QR@1224|Proteobacteria,42VEI@68525|delta/epsilon subdivisions,2WRFX@28221|Deltaproteobacteria,2MKUR@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6860568_0	264198.Reut_B5072	7.669e-11	70.0	COG1873@1|root,COG1873@2|Bacteria,1QTWZ@1224|Proteobacteria,2VT3J@28216|Betaproteobacteria,1K7KH@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_6884748_4	1041930.Mtc_0647	5.493e-18	87.0	COG3039@1|root,arCOG06508@2157|Archaea,2Y031@28890|Euryarchaeota,2NAX1@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase domain (DUF772)	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_6884748_0	694440.JOMF01000005_gene278	3.024e-77	270.0	COG0206@1|root,arCOG02201@2157|Archaea,2XSV8@28890|Euryarchaeota,2N934@224756|Methanomicrobia	224756|Methanomicrobia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ-1	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_6884748_3	589924.Ferp_0825	3.167e-19	92.0	COG1255@1|root,arCOG04385@2157|Archaea,2XYWU@28890|Euryarchaeota,24795@183980|Archaeoglobi	183980|Archaeoglobi	S	Belongs to the UPF0146 family	-	-	-	ko:K09713	-	-	-	-	ko00000	-	-	-	UPF0146
HKD1_k127_6884748_1	1116472.MGMO_115c00240	3.231e-32	134.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_6884748_2	671065.MetMK1DRAFT_00020950	8.207e-31	126.0	COG1656@1|root,arCOG04290@2157|Archaea,2XQD5@28889|Crenarchaeota	28889|Crenarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
HKD1_k127_689093_6	589924.Ferp_1628	1.909e-78	271.0	COG0079@1|root,arCOG04273@2157|Archaea,2XTFZ@28890|Euryarchaeota,245U8@183980|Archaeoglobi	183980|Archaeoglobi	E	Imidazole acetol-phosphate transaminase	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_689093_2	351160.RCIX1575	2.921e-135	441.0	COG4992@1|root,arCOG00914@2157|Archaea,2XTKV@28890|Euryarchaeota,2N98X@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_689093_10	224325.AF_0575	9.209e-48	179.0	COG0491@1|root,arCOG00504@2157|Archaea,2XURS@28890|Euryarchaeota,2467X@183980|Archaeoglobi	183980|Archaeoglobi	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_689093_1	269797.Mbar_A2129	6.613e-155	499.0	COG0422@1|root,arCOG02741@2157|Archaea,2XTMD@28890|Euryarchaeota,2N91J@224756|Methanomicrobia	224756|Methanomicrobia	H	Thiamine biosynthesis protein ThiC	thiC-1	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
HKD1_k127_689093_9	868864.Dester_0090	5.251e-53	193.0	COG2078@1|root,COG2078@2|Bacteria,2G44K@200783|Aquificae	200783|Aquificae	S	PFAM AMMECR1 domain protein	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HKD1_k127_689093_5	56780.SYN_02131	7.36e-80	272.0	COG0655@1|root,COG0655@2|Bacteria,1N3NQ@1224|Proteobacteria,42TRR@68525|delta/epsilon subdivisions,2WQ13@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_689093_7	351160.RRC56	7.291e-65	226.0	COG1731@1|root,arCOG01322@2157|Archaea,2XX0K@28890|Euryarchaeota,2N9J0@224756|Methanomicrobia	224756|Methanomicrobia	H	TIGRFAM riboflavin synthase	ribC	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_689093_11	410359.Pcal_2030	2.324e-06	57.0	COG1525@1|root,arCOG03193@2157|Archaea	2157|Archaea	L	PFAM nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_689093_4	1094980.Mpsy_0392	4.6e-98	327.0	COG3640@1|root,arCOG00587@2157|Archaea,2XW7J@28890|Euryarchaeota,2N9VV@224756|Methanomicrobia	224756|Methanomicrobia	D	PFAM Cobyrinic acid a,c-diamide synthase	-	-	-	ko:K07321	-	-	-	-	ko00000	-	-	-	CbiA
HKD1_k127_689093_3	269797.Mbar_A0862	1.488e-131	428.0	COG0150@1|root,arCOG00639@2157|Archaea,2XTBA@28890|Euryarchaeota,2N9C4@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM AIR synthase related protein	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_689093_0	1094980.Mpsy_2178	8.363e-163	526.0	COG0527@1|root,arCOG00861@2157|Archaea,2XTJ0@28890|Euryarchaeota,2N91C@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_689093_8	351160.LRC364	4.883e-63	218.0	COG0480@1|root,arCOG01559@2157|Archaea,2XUMQ@28890|Euryarchaeota,2N9FS@224756|Methanomicrobia	224756|Methanomicrobia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K03234	ko04152,ko04921,map04152,map04921	-	-	-	ko00000,ko00001,ko03012,ko04147	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_6911256_0	243232.MJ_0281	2.805e-48	178.0	COG1913@1|root,arCOG00458@2157|Archaea,2XSVV@28890|Euryarchaeota	28890|Euryarchaeota	S	zinc metalloprotease whose natural substrate is	amzA	GO:0003674,GO:0003824,GO:0005488,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008270,GO:0016787,GO:0019538,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0046872,GO:0046914,GO:0071704,GO:0140096,GO:1901564	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
HKD1_k127_6920852_0	402777.KB235898_gene4978	3.921e-74	286.0	COG2931@1|root,COG4932@1|root,COG2931@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
HKD1_k127_6941832_1	755732.Fluta_3347	8.761e-05	51.0	COG1533@1|root,COG1533@2|Bacteria,4NE62@976|Bacteroidetes,1HYJS@117743|Flavobacteriia,2PBEU@246874|Cryomorphaceae	976|Bacteroidetes	L	PFAM Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_6941832_0	926560.KE387023_gene1701	6.458e-115	388.0	COG0642@1|root,COG0642@2|Bacteria,COG2205@2|Bacteria	2|Bacteria	T	PhoQ Sensor	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,DUF3365,GAF,GAF_2,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_6950655_0	269797.Mbar_A2126	1.619e-132	425.0	COG0172@1|root,arCOG00403@2157|Archaea,2XUK2@28890|Euryarchaeota,2N9B1@224756|Methanomicrobia	224756|Methanomicrobia	J	able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	-	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF692.Mbar_A2126	-
HKD1_k127_6950655_1	368407.Memar_1667	1.18e-107	356.0	COG1313@1|root,arCOG00934@2157|Archaea,2XUM6@28890|Euryarchaeota,2N9U1@224756|Methanomicrobia	224756|Methanomicrobia	C	Fe-S protein PflX, homolog of pyruvate formate lyase activating	pflX	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_6961604_0	697282.Mettu_0545	1.776e-275	871.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1XEHU@135618|Methylococcales	135618|Methylococcales	G	TIGRFAM alpha-glucan	-	-	-	-	-	-	-	-	-	-	-	-	DUF3417,Phosphorylase
HKD1_k127_6961604_1	1408813.AYMG01000039_gene2247	7.403e-05	48.0	COG0671@1|root,COG0671@2|Bacteria,4NI23@976|Bacteroidetes,1IU3B@117747|Sphingobacteriia	976|Bacteroidetes	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_6961604_2	218851.Aquca_045_00194.1	0.0001843	52.0	COG0170@1|root,KOG4453@2759|Eukaryota,37QCU@33090|Viridiplantae,3GCR8@35493|Streptophyta	35493|Streptophyta	K	Phytol kinase	-	GO:0000003,GO:0001101,GO:0003006,GO:0003674,GO:0003824,GO:0006066,GO:0006629,GO:0006714,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0007275,GO:0008150,GO:0008152,GO:0009719,GO:0009725,GO:0009737,GO:0009791,GO:0009908,GO:0009987,GO:0010033,GO:0016093,GO:0016301,GO:0016310,GO:0016487,GO:0016740,GO:0016772,GO:0016773,GO:0016999,GO:0017144,GO:0022414,GO:0032501,GO:0032502,GO:0033993,GO:0034308,GO:0042221,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0048367,GO:0048437,GO:0048438,GO:0048440,GO:0048467,GO:0048608,GO:0048731,GO:0048827,GO:0048856,GO:0050896,GO:0052668,GO:0052669,GO:0052670,GO:0052671,GO:0052673,GO:0061458,GO:0071704,GO:0090567,GO:0097305,GO:0099402,GO:1901615,GO:1901700	2.7.1.216	ko:K15892	ko00900,ko01130,map00900,map01130	-	R09849	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	-
HKD1_k127_699182_0	439481.Aboo_0277	2.015e-75	265.0	COG0438@1|root,arCOG01403@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase, group 1	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K12996	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	DUF1972,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_7064951_6	521011.Mpal_2113	9.478e-16	77.0	COG0834@1|root,COG1301@1|root,arCOG01799@2157|Archaea,arCOG04335@2157|Archaea	2157|Archaea	C	COG1301 Na H -dicarboxylate symporters	gltP	GO:0001504,GO:0001505,GO:0003333,GO:0003674,GO:0005215,GO:0005283,GO:0005310,GO:0005326,GO:0005342,GO:0005343,GO:0005416,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0006814,GO:0006820,GO:0006821,GO:0006835,GO:0006836,GO:0006865,GO:0008150,GO:0008324,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015077,GO:0015081,GO:0015103,GO:0015108,GO:0015171,GO:0015172,GO:0015179,GO:0015183,GO:0015291,GO:0015293,GO:0015294,GO:0015318,GO:0015370,GO:0015556,GO:0015672,GO:0015698,GO:0015711,GO:0015740,GO:0015800,GO:0015807,GO:0015849,GO:0016043,GO:0022607,GO:0022804,GO:0022857,GO:0022890,GO:0030001,GO:0034220,GO:0035725,GO:0042802,GO:0043090,GO:0043933,GO:0044085,GO:0046873,GO:0046942,GO:0046943,GO:0051179,GO:0051234,GO:0051259,GO:0051260,GO:0055085,GO:0065003,GO:0065007,GO:0065008,GO:0070206,GO:0070207,GO:0070778,GO:0071702,GO:0071705,GO:0071840,GO:0089718,GO:0098655,GO:0098656,GO:0098657,GO:0098660,GO:0098661,GO:0098662,GO:0098739,GO:0140009,GO:1902475,GO:1902476,GO:1903825,GO:1905039	-	ko:K02030,ko:K07862	-	M00236	-	-	ko00000,ko00002,ko02000	2.A.23.4,3.A.1.3	-	-	SBP_bac_3,SDF
HKD1_k127_7064951_8	1382356.JQMP01000003_gene2478	0.0001312	47.0	COG1525@1|root,COG1525@2|Bacteria,2GBHE@200795|Chloroflexi,27YTT@189775|Thermomicrobia	189775|Thermomicrobia	L	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7064951_3	1094980.Mpsy_1049	7.725e-68	235.0	arCOG04740@1|root,arCOG04740@2157|Archaea,2XU9C@28890|Euryarchaeota,2N9U2@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7064951_2	269797.Mbar_A2840	4.899e-112	368.0	COG0281@1|root,arCOG01331@2157|Archaea,2XTRZ@28890|Euryarchaeota,2N972@224756|Methanomicrobia	224756|Methanomicrobia	O	Belongs to the peptidase M48B family	htpX	-	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_7064951_5	706587.Desti_1228	4.473e-43	161.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,42MCS@68525|delta/epsilon subdivisions,2WQGI@28221|Deltaproteobacteria,2MQM2@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	FKBP-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HKD1_k127_7064951_4	593750.Metfor_1184	6.5e-52	190.0	COG1432@1|root,arCOG02408@2157|Archaea	2157|Archaea	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD1_k127_7064951_7	1384049.CD29_00740	6.968e-08	57.0	COG1893@1|root,COG1893@2|Bacteria,1V1NJ@1239|Firmicutes,4HFWT@91061|Bacilli,3IX0W@400634|Lysinibacillus	91061|Bacilli	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	panE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006573,GO:0006575,GO:0006732,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008677,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU15110	ApbA,ApbA_C
HKD1_k127_7064951_0	1041930.Mtc_1712	1.438e-126	410.0	COG1122@1|root,arCOG00202@2157|Archaea,2XVRT@28890|Euryarchaeota,2N9CJ@224756|Methanomicrobia	224756|Methanomicrobia	E	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD1_k127_7064951_1	269797.Mbar_A1058	1.694e-112	370.0	COG0619@1|root,arCOG02250@2157|Archaea,2XVYE@28890|Euryarchaeota,2N95B@224756|Methanomicrobia	224756|Methanomicrobia	P	Cobalt transport protein	-	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD1_k127_7078706_1	399549.Msed_0640	3.081e-31	130.0	COG0071@1|root,arCOG01833@2157|Archaea,2XQD6@28889|Crenarchaeota	28889|Crenarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_7078706_0	269797.Mbar_A1408	9.155e-98	333.0	COG3547@1|root,arCOG03585@2157|Archaea,2XWFH@28890|Euryarchaeota	28890|Euryarchaeota	L	COG3547 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_7081127_1	1502851.FG93_01105	1.608e-49	179.0	COG2346@1|root,COG2346@2|Bacteria,1Q38S@1224|Proteobacteria,2UJT6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD1_k127_7081127_2	1047013.AQSP01000144_gene925	1.313e-43	163.0	COG1814@1|root,COG1814@2|Bacteria	2|Bacteria	S	cellular manganese ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_7081127_3	1173022.Cri9333_1649	3.105e-38	151.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_2,TPR_8
HKD1_k127_7081127_0	1047013.AQSP01000109_gene2441	4.587e-84	286.0	COG0500@1|root,COG2226@2|Bacteria,2NP8K@2323|unclassified Bacteria	2|Bacteria	Q	ubiE/COQ5 methyltransferase family	arsM	-	2.1.1.137,2.1.1.79	ko:K00574,ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD1_k127_7095860_1	269797.Mbar_A2161	1.359e-15	78.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_7095860_2	1042877.GQS_04155	3.178e-15	79.0	COG0640@1|root,arCOG06697@2157|Archaea,2Y3KH@28890|Euryarchaeota,244FJ@183968|Thermococci	183968|Thermococci	K	Bacterial regulatory protein, arsR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD1_k127_7095860_0	485913.Krac_6458	4.834e-37	142.0	COG2350@1|root,COG2350@2|Bacteria	2|Bacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_7101130_0	1047013.AQSP01000111_gene1664	2.574e-180	571.0	COG0473@1|root,COG0473@2|Bacteria,2NP0Z@2323|unclassified Bacteria	2|Bacteria	CE	Isocitrate/isopropylmalate dehydrogenase	icd	-	1.1.1.41,1.1.1.85	ko:K00030,ko:K00052	ko00020,ko00290,ko00660,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00290,map00660,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00432,M00535	R00709,R00994,R04426,R10052	RC00084,RC00114,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_7101130_1	330779.Saci_1199	3.767e-69	250.0	COG1208@1|root,arCOG00666@2157|Archaea,2XQ37@28889|Crenarchaeota	28889|Crenarchaeota	M	PFAM transferase hexapeptide repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,NTP_transferase
HKD1_k127_7148593_0	192952.MM_0135	4.5e-148	480.0	COG1900@1|root,arCOG00621@2157|Archaea,2XTFR@28890|Euryarchaeota,2N98V@224756|Methanomicrobia	224756|Methanomicrobia	S	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,HcyBio
HKD1_k127_7152974_3	246197.MXAN_6506	5.615e-27	114.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,43AD6@68525|delta/epsilon subdivisions,2WJCC@28221|Deltaproteobacteria,2YX1N@29|Myxococcales	28221|Deltaproteobacteria	U	Sulfate permease	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD1_k127_7152974_2	192952.MM_1454	1.198e-27	117.0	COG0589@1|root,arCOG02053@2157|Archaea,2Y8D9@28890|Euryarchaeota	2157|Archaea	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_7152974_4	368407.Memar_1908	1.21e-16	84.0	COG0840@1|root,arCOG03007@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_7152974_1	679926.Mpet_2715	4.276e-34	137.0	COG0840@1|root,arCOG03642@2157|Archaea	2157|Archaea	NT	PFAM Cache, type 2 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_7152974_5	500153.JOEK01000010_gene4710	3.611e-13	76.0	COG1917@1|root,COG1917@2|Bacteria,2IRV4@201174|Actinobacteria	201174|Actinobacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7152974_0	1094980.Mpsy_1847	1.386e-49	179.0	COG0346@1|root,arCOG02706@2157|Archaea,2Y0N9@28890|Euryarchaeota,2NAVW@224756|Methanomicrobia	224756|Methanomicrobia	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_7163947_0	1123371.ATXH01000019_gene613	6.541e-52	184.0	COG2148@1|root,COG2148@2|Bacteria,2GHZH@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HKD1_k127_7163947_2	909663.KI867150_gene2493	1.933e-29	124.0	COG0250@1|root,COG0250@2|Bacteria,1Q2A0@1224|Proteobacteria,437WT@68525|delta/epsilon subdivisions,2X36G@28221|Deltaproteobacteria,2MSA8@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcription termination factor nusG	-	-	-	-	-	-	-	-	-	-	-	-	NusG
HKD1_k127_7163947_1	237368.SCABRO_01031	1.048e-33	142.0	COG1408@1|root,COG1408@2|Bacteria	2|Bacteria	S	Calcineurin-like phosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_7165408_0	877455.Metbo_1761	1.181e-87	295.0	COG2060@1|root,arCOG04804@2157|Archaea,2XU4N@28890|Euryarchaeota	28890|Euryarchaeota	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD1_k127_7165408_1	1094980.Mpsy_2553	4.179e-64	231.0	COG0168@1|root,arCOG04145@2157|Archaea,2XT89@28890|Euryarchaeota,2N9GA@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM Cation	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_7212807_0	192952.MM_3190	3.06e-57	209.0	COG1650@1|root,arCOG01616@2157|Archaea,2XUM0@28890|Euryarchaeota,2N9S6@224756|Methanomicrobia	224756|Methanomicrobia	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
HKD1_k127_7212807_1	269797.Mbar_A1863	1.985e-23	103.0	COG0382@1|root,arCOG00476@2157|Archaea,2XUHS@28890|Euryarchaeota,2N9SR@224756|Methanomicrobia	224756|Methanomicrobia	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42	ko:K17105	ko00564,map00564	-	R04520	RC01171	ko00000,ko00001,ko01000	-	-	-	UbiA
HKD1_k127_7248518_1	309799.DICTH_0752	1.806e-16	87.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_7248518_0	404380.Gbem_3977	5.509e-27	119.0	COG3056@1|root,COG3056@2|Bacteria,1NKTA@1224|Proteobacteria	1224|Proteobacteria	M	Uncharacterized lipoprotein	-	-	-	ko:K07286	-	-	-	-	ko00000	-	-	-	Lipoprotein_16
HKD1_k127_7248518_3	404380.Gbem_2532	1.032e-13	72.0	2DFV1@1|root,2ZT9B@2|Bacteria	2|Bacteria	S	Alkylmercury lyase	-	-	-	-	-	-	-	-	-	-	-	-	MerB
HKD1_k127_7290260_1	224325.AF_1012	8.071e-52	190.0	COG1244@1|root,arCOG01360@2157|Archaea,2XT5Q@28890|Euryarchaeota,245R5@183980|Archaeoglobi	183980|Archaeoglobi	S	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K06936	-	-	-	-	ko00000	-	-	-	Radical_SAM
HKD1_k127_7290260_0	264732.Moth_2420	1.536e-59	216.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,42EKM@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_7290260_2	926690.KE386573_gene3084	2.599e-40	152.0	COG1474@1|root,arCOG00467@2157|Archaea,2XU73@28890|Euryarchaeota,23S7S@183963|Halobacteria	183963|Halobacteria	L	Involved in regulation of DNA replication	orc1	-	-	ko:K10725	-	-	-	-	ko00000,ko03032	-	-	-	AAA,AAA_16,Cdc6_C
HKD1_k127_7334597_6	269797.Mbar_A1273	1.782e-16	83.0	COG1400@1|root,arCOG01217@2157|Archaea	2157|Archaea	J	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP	srp19	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0006605,GO:0006612,GO:0006613,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008312,GO:0015031,GO:0015833,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:1901363	-	ko:K03105	ko03060,map03060	-	-	-	ko00000,ko00001,ko02044	3.A.5.7,3.A.5.9	-	-	SRP19
HKD1_k127_7334597_1	593750.Metfor_2544	8.834e-125	406.0	COG0535@1|root,arCOG00956@2157|Archaea,2XU9R@28890|Euryarchaeota,2N96X@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM Radical SAM domain protein	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_7334597_2	1089553.Tph_c15310	1.181e-102	346.0	COG0535@1|root,COG0535@2|Bacteria,1TR85@1239|Firmicutes,249NQ@186801|Clostridia,42FAP@68295|Thermoanaerobacterales	186801|Clostridia	C	SMART Elongator protein 3 MiaB NifB	-	-	-	ko:K22226	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_7334597_3	580327.Tthe_1598	9.971e-99	339.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,42ES8@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
HKD1_k127_7334597_4	1094980.Mpsy_2487	3.491e-89	303.0	COG0181@1|root,arCOG04299@2157|Archaea,2XTBP@28890|Euryarchaeota,2N97F@224756|Methanomicrobia	224756|Methanomicrobia	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A1465	Porphobil_deam,Porphobil_deamC
HKD1_k127_7334597_0	1094980.Mpsy_2488	1.782e-178	568.0	COG0001@1|root,arCOG00918@2157|Archaea,2XTRI@28890|Euryarchaeota,2N937@224756|Methanomicrobia	224756|Methanomicrobia	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7334597_5	868131.MSWAN_2018	1.728e-57	208.0	COG1641@1|root,arCOG02701@2157|Archaea,2XV3G@28890|Euryarchaeota,23NRK@183925|Methanobacteria	183925|Methanobacteria	S	Belongs to the LarC family	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_7350504_7	368407.Memar_2285	3.018e-11	65.0	arCOG00346@1|root,arCOG00346@2157|Archaea,2XU0A@28890|Euryarchaeota	28890|Euryarchaeota	S	LUD domain	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
HKD1_k127_7350504_1	269797.Mbar_A3236	1.866e-76	263.0	COG1018@1|root,arCOG02200@2157|Archaea,2XVD3@28890|Euryarchaeota,2N9JH@224756|Methanomicrobia	224756|Methanomicrobia	C	Oxidoreductase FAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_6,NAD_binding_1
HKD1_k127_7350504_6	643562.Daes_0808	7.957e-18	85.0	COG1773@1|root,COG1773@2|Bacteria,1NES3@1224|Proteobacteria,42VN9@68525|delta/epsilon subdivisions,2WRT2@28221|Deltaproteobacteria,2MCJQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Belongs to the rubredoxin family	-	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0008199,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0055114	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD1_k127_7350504_0	1121459.AQXE01000001_gene2813	2.24e-127	417.0	COG3185@1|root,COG3185@2|Bacteria,1R5AJ@1224|Proteobacteria,42YP5@68525|delta/epsilon subdivisions,2WU50@28221|Deltaproteobacteria,2M9MU@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	4-Hydroxyphenylpyruvate dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7350504_5	593750.Metfor_2793	3.258e-25	108.0	arCOG03597@1|root,arCOG03597@2157|Archaea,2Y07Y@28890|Euryarchaeota,2NBAH@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function (DUF2769)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2769
HKD1_k127_7350504_2	368408.Tpen_1513	4.277e-73	262.0	COG0531@1|root,arCOG00009@2157|Archaea,2XQNU@28889|Crenarchaeota	28889|Crenarchaeota	E	Spore germination protein	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_7350504_3	1122165.AUHS01000032_gene2267	4.056e-36	139.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,1S9PQ@1236|Gammaproteobacteria,1JEVN@118969|Legionellales	118969|Legionellales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_7350504_4	368407.Memar_2421	7.712e-35	143.0	COG2133@1|root,COG3794@1|root,arCOG02796@2157|Archaea,arCOG02929@2157|Archaea,2XT1Q@28890|Euryarchaeota	28890|Euryarchaeota	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,GSDH
HKD1_k127_7382490_5	755178.Cyan10605_2788	2.153e-58	213.0	COG2048@1|root,COG2048@2|Bacteria,1G2JG@1117|Cyanobacteria	1117|Cyanobacteria	C	Heterodisulfide reductase, subunit B	-	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	CCG
HKD1_k127_7382490_7	237368.SCABRO_01879	4.868e-30	126.0	COG1150@1|root,COG1150@2|Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	hdrC	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03389,ko:K03390,ko:K16887,ko:K18930	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3424	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_17,Fer4_7,Fer4_8,Fer4_9
HKD1_k127_7382490_3	1094980.Mpsy_2950	1.601e-88	304.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
HKD1_k127_7382490_8	1094980.Mpsy_2950	1.578e-28	117.0	COG1145@1|root,arCOG02180@2157|Archaea,2XV84@28890|Euryarchaeota,2N9ND@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	fwdF-1	-	-	ko:K00205	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002	-	-	-	Fer4,Fer4_4,Fer4_7
HKD1_k127_7382490_0	1094980.Mpsy_2951	6.363e-320	996.0	COG1148@1|root,COG1908@1|root,arCOG02235@2157|Archaea,arCOG02476@2157|Archaea,2XT3X@28890|Euryarchaeota,2N9AI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	hdrA-2	-	1.8.7.3,1.8.98.4,1.8.98.5,1.8.98.6	ko:K03388	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00356,M00357,M00563,M00567	R04540,R11928,R11931,R11943,R11944	RC00011	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_17,Fer4_7,Fer4_9,FlpD,Pyr_redox_2
HKD1_k127_7382490_11	269797.Mbar_A2098	0.0006215	44.0	arCOG05123@1|root,arCOG05123@2157|Archaea,2Y3HV@28890|Euryarchaeota,2NAQC@224756|Methanomicrobia	224756|Methanomicrobia	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_7382490_6	192952.MM_0225	3.121e-43	162.0	arCOG05123@1|root,arCOG05123@2157|Archaea,2Y3HV@28890|Euryarchaeota,2NAQC@224756|Methanomicrobia	224756|Methanomicrobia	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_7382490_4	304371.MCP_2219	1.39e-64	230.0	COG2106@1|root,arCOG04069@2157|Archaea,2XSZI@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
HKD1_k127_7382490_1	368407.Memar_0564	2.744e-119	391.0	COG0087@1|root,arCOG04070@2157|Archaea,2XT9B@28890|Euryarchaeota,2N98A@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rpl3	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_7382490_2	269797.Mbar_A0109	2.098e-94	317.0	COG0469@1|root,arCOG04071@2157|Archaea,2XTXX@28890|Euryarchaeota,2N9DG@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome	rpl4	-	-	ko:K02930	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD1_k127_7382490_10	351160.RCIX2543	8.799e-21	93.0	COG0089@1|root,arCOG04072@2157|Archaea,2XYPG@28890|Euryarchaeota,2N9ZC@224756|Methanomicrobia	224756|Methanomicrobia	J	Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome	rpl23	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD1_k127_7382490_9	1094980.Mpsy_1143	2.05e-24	103.0	COG0090@1|root,arCOG04067@2157|Archaea,2XTCS@28890|Euryarchaeota,2N99T@224756|Methanomicrobia	224756|Methanomicrobia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_7411197_1	269799.Gmet_2178	2.415e-33	139.0	COG1621@1|root,COG1621@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 32 family	-	-	2.4.1.10	ko:K00692	ko00500,ko01100,ko02020,map00500,map01100,map02020	-	R05140	RC00077	ko00000,ko00001,ko01000,ko01003	-	GH68	-	Alpha-L-AF_C,Alpha-amylase,Big_2,CBM_4_9,Glyco_hydro_32N,Glyco_hydro_43,Glyco_hydro_66,Glyco_hydro_68,Laminin_G_3,PUD,SLH,VCBS
HKD1_k127_7411197_0	56780.SYN_02589	0.0	1689.0	COG0458@1|root,COG0458@2|Bacteria,1NPMZ@1224|Proteobacteria,42NF3@68525|delta/epsilon subdivisions,2WM4C@28221|Deltaproteobacteria,2MQ8X@213462|Syntrophobacterales	28221|Deltaproteobacteria	F	Carbamoyl-phosphate synthetase large chain, oligomerisation	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0661	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_7452203_3	593750.Metfor_1610	3.002e-75	259.0	COG0189@1|root,arCOG01589@2157|Archaea,2XT55@28890|Euryarchaeota	28890|Euryarchaeota	H	Glutathione synthase ribosomal protein S6 modification enzyme (Glutaminyl transferase)	rimK	-	-	ko:K05844	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RimK
HKD1_k127_7452203_4	224325.AF_2306	3.663e-43	163.0	COG0727@1|root,arCOG02586@2157|Archaea,2XZ0H@28890|Euryarchaeota	28890|Euryarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_7452203_1	456442.Mboo_1624	2.386e-120	398.0	arCOG02723@1|root,arCOG02723@2157|Archaea,2XW9T@28890|Euryarchaeota	28890|Euryarchaeota	H	PFAM glutamate--cysteine ligase, GCS2	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
HKD1_k127_7452203_0	877455.Metbo_0228	3.857e-128	420.0	COG0484@1|root,arCOG02846@2157|Archaea,2XV5D@28890|Euryarchaeota,23NRW@183925|Methanobacteria	183925|Methanobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_7452203_2	1121289.JHVL01000002_gene2355	2.553e-84	286.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,36DJ7@31979|Clostridiaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_7463050_0	1094980.Mpsy_1484	1.158e-185	600.0	COG0417@1|root,arCOG00328@2157|Archaea,2XU1K@28890|Euryarchaeota,2N9IK@224756|Methanomicrobia	224756|Methanomicrobia	L	SMART DNA-directed DNA polymerase B	polB-1	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
HKD1_k127_7463050_5	1094980.Mpsy_0984	5.803e-140	452.0	COG0533@1|root,arCOG01183@2157|Archaea,2Y86G@28890|Euryarchaeota,2NBNX@224756|Methanomicrobia	224756|Methanomicrobia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Kae1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity	gcp	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_7463050_6	589924.Ferp_1014	4.374e-137	450.0	COG0151@1|root,arCOG04415@2157|Archaea,2XTRV@28890|Euryarchaeota,24633@183980|Archaeoglobi	183980|Archaeoglobi	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_7463050_2	1121468.AUBR01000046_gene1915	1.073e-173	556.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,42FNV@68295|Thermoanaerobacterales	186801|Clostridia	H	TIGRFAM glutamine synthetase, type I	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_7463050_16	489825.LYNGBM3L_73980	7.621e-22	99.0	COG0745@1|root,COG0745@2|Bacteria,1G51F@1117|Cyanobacteria,1HBR7@1150|Oscillatoriales	1117|Cyanobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_7463050_10	1041930.Mtc_1521	1.433e-100	336.0	COG0731@1|root,arCOG04174@2157|Archaea,2XSTF@28890|Euryarchaeota,2N9E5@224756|Methanomicrobia	224756|Methanomicrobia	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
HKD1_k127_7463050_17	196164.23493055	1.233e-10	74.0	COG1357@1|root,COG1357@2|Bacteria,2HQ9F@201174|Actinobacteria,22QTC@1653|Corynebacteriaceae	201174|Actinobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide_3
HKD1_k127_7463050_9	1094980.Mpsy_0336	5.091e-116	379.0	COG0040@1|root,arCOG02208@2157|Archaea,2Y2ZH@28890|Euryarchaeota,2NA8F@224756|Methanomicrobia	224756|Methanomicrobia	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD1_k127_7463050_19	1365176.N186_06790	7.202e-05	54.0	arCOG01151@1|root,arCOG01151@2157|Archaea	2157|Archaea	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD1_k127_7463050_13	1041930.Mtc_1881	6.548e-44	166.0	COG0778@1|root,arCOG00288@2157|Archaea,2XY3A@28890|Euryarchaeota,2NAXX@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_7463050_3	1132509.C447_03776	2.399e-159	518.0	COG1243@1|root,arCOG01361@2157|Archaea,2XT9Z@28890|Euryarchaeota,23SRU@183963|Halobacteria	183963|Halobacteria	K	histone acetyltransferase, ELP3 family	elp3	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
HKD1_k127_7463050_14	192952.MM_2039	1.161e-43	162.0	COG2007@1|root,arCOG04154@2157|Archaea,2XYXX@28890|Euryarchaeota,2N9UK@224756|Methanomicrobia	224756|Methanomicrobia	J	PFAM ribosomal protein S8E	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
HKD1_k127_7463050_18	529709.PYCH_18490	9.374e-09	67.0	COG0438@1|root,arCOG01403@2157|Archaea,2XUSA@28890|Euryarchaeota,243JQ@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_7463050_4	186497.PF0794	7.373e-147	472.0	COG0381@1|root,arCOG01392@2157|Archaea,2XU0B@28890|Euryarchaeota,2451C@183968|Thermococci	183968|Thermococci	M	UDP-N-acetylglucosamine 2-epimerase	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HKD1_k127_7463050_12	589924.Ferp_2378	4.782e-79	267.0	COG0110@1|root,arCOG01848@2157|Archaea,2XWJM@28890|Euryarchaeota,2474T@183980|Archaeoglobi	183980|Archaeoglobi	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_7463050_11	370438.PTH_0379	4.423e-100	334.0	COG0673@1|root,COG0673@2|Bacteria,1V0J1@1239|Firmicutes,24IDB@186801|Clostridia,2660B@186807|Peptococcaceae	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_7463050_7	272844.PAB0774	7.007e-136	442.0	COG0399@1|root,arCOG00118@2157|Archaea,2XTRQ@28890|Euryarchaeota,243U2@183968|Thermococci	183968|Thermococci	E	Beta-eliminating lyase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_7463050_8	192952.MM_0302	6.746e-124	408.0	COG1208@1|root,arCOG00666@2157|Archaea,2XT8U@28890|Euryarchaeota,2N9G1@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transferase
HKD1_k127_7463050_1	351160.RCIX42	8.376e-180	572.0	COG0017@1|root,arCOG00406@2157|Archaea,2XTRE@28890|Euryarchaeota,2N94I@224756|Methanomicrobia	224756|Methanomicrobia	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_7463050_15	1038859.AXAU01000002_gene391	1.13e-27	116.0	COG0591@1|root,COG0642@1|root,COG0591@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2TR1M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	resE	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg,SSF
HKD1_k127_7500876_5	351160.RCIX1987	2.438e-26	112.0	COG1720@1|root,arCOG00761@2157|Archaea,2XYZ5@28890|Euryarchaeota,2N9XJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_7500876_3	192952.MM_0574	9.766e-49	178.0	COG0394@1|root,arCOG04425@2157|Archaea,2XZ4R@28890|Euryarchaeota,2N9TH@224756|Methanomicrobia	224756|Methanomicrobia	T	PFAM low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_7500876_0	525904.Tter_0502	6.928e-166	541.0	COG0449@1|root,COG0449@2|Bacteria,2NNWC@2323|unclassified Bacteria	2|Bacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_7500876_1	593750.Metfor_1422	1.564e-98	330.0	COG0451@1|root,arCOG01369@2157|Archaea,2XTTP@28890|Euryarchaeota,2N940@224756|Methanomicrobia	224756|Methanomicrobia	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A0021	Epimerase,GDP_Man_Dehyd
HKD1_k127_7500876_6	368407.Memar_0227	2.267e-20	96.0	COG0526@1|root,arCOG01972@2157|Archaea,2XXRJ@28890|Euryarchaeota,2N9YG@224756|Methanomicrobia	224756|Methanomicrobia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_7500876_4	118168.MC7420_6504	6.786e-41	162.0	COG0457@1|root,COG0457@2|Bacteria,1G20P@1117|Cyanobacteria,1H8AZ@1150|Oscillatoriales	1117|Cyanobacteria	L	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_8
HKD1_k127_7500876_7	68260.JOAY01000058_gene5374	8.379e-12	72.0	2DZA9@1|root,32V71@2|Bacteria,2IF7X@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7500876_2	667014.Thein_0108	8.891e-92	308.0	COG4106@1|root,COG4106@2|Bacteria	2|Bacteria	FG	trans-aconitate 2-methyltransferase activity	-	-	2.1.1.144,2.1.1.197	ko:K00598,ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD1_k127_7500876_8	216596.RL1885	1.506e-05	49.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,4BBNG@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_2,RMMBL
HKD1_k127_7524516_7	565033.GACE_0359	1.612e-06	50.0	COG1152@1|root,arCOG02428@2157|Archaea,2XTBY@28890|Euryarchaeota,245P2@183980|Archaeoglobi	183980|Archaeoglobi	C	Part of the ACDS complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). The alpha-epsilon subcomponent functions as a carbon monoxide dehydrogenase	cdhA	-	1.2.7.4	ko:K00192	ko00680,ko01120,ko01200,map00680,map01120,map01200	M00422	R07157	RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD1_k127_7524516_2	304371.MCP_1952	1.678e-92	316.0	COG0079@1|root,arCOG04273@2157|Archaea,2XV1E@28890|Euryarchaeota,2N9D3@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,zf-like
HKD1_k127_7524516_6	1094980.Mpsy_3100	5.194e-21	96.0	COG0079@1|root,COG2158@1|root,arCOG04273@2157|Archaea,arCOG05056@2157|Archaea,2XV1E@28890|Euryarchaeota,2N9D3@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2,zf-like
HKD1_k127_7524516_3	192952.MM_2059	4.458e-67	239.0	COG1270@1|root,arCOG04274@2157|Archaea,2XT37@28890|Euryarchaeota,2N9JD@224756|Methanomicrobia	224756|Methanomicrobia	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
HKD1_k127_7524516_4	1173029.JH980292_gene2950	2.665e-55	223.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1V0@1117|Cyanobacteria,1HA6B@1150|Oscillatoriales	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
HKD1_k127_7524516_5	304371.MCP_0133	1.297e-34	136.0	COG1145@1|root,arCOG02460@2157|Archaea,2Y0N6@28890|Euryarchaeota,2NA23@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM 4Fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,NIL
HKD1_k127_7524516_0	1041930.Mtc_0355	9.256e-193	614.0	COG1900@1|root,arCOG00620@2157|Archaea,2XVEU@28890|Euryarchaeota,2N93A@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HcyBio
HKD1_k127_7524516_1	589924.Ferp_0626	1.725e-97	332.0	COG1032@1|root,arCOG01357@2157|Archaea,2XUCZ@28890|Euryarchaeota,246Y8@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_7545897_3	368407.Memar_2102	3.941e-33	132.0	COG0038@1|root,arCOG02569@2157|Archaea,2Y26D@28890|Euryarchaeota	28890|Euryarchaeota	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
HKD1_k127_7545897_1	1094980.Mpsy_0131	7.719e-44	162.0	COG3293@1|root,arCOG03507@2157|Archaea,2Y10G@28890|Euryarchaeota,2N9ZB@224756|Methanomicrobia	224756|Methanomicrobia	L	Putative transposase of IS4/5 family (DUF4096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD1_k127_7545897_2	1094980.Mpsy_0288	1.025e-37	149.0	COG3293@1|root,arCOG03506@2157|Archaea,2Y1BH@28890|Euryarchaeota,2NA3U@224756|Methanomicrobia	224756|Methanomicrobia	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_2
HKD1_k127_7545897_0	795359.TOPB45_0005	2.587e-84	292.0	COG3264@1|root,COG3264@2|Bacteria,2GHQX@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_7550613_6	1158318.ATXC01000001_gene38	2.339e-54	195.0	COG1225@1|root,COG1225@2|Bacteria,2G42T@200783|Aquificae	200783|Aquificae	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_7550613_15	1123517.JOMR01000001_gene1673	1.739e-16	89.0	COG2961@1|root,COG2961@2|Bacteria,1MWGA@1224|Proteobacteria,1RNI1@1236|Gammaproteobacteria,460F1@72273|Thiotrichales	72273|Thiotrichales	S	Specifically methylates the adenine in position 2030 of 23S rRNA	rlmJ	-	2.1.1.266	ko:K07115	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	RsmJ
HKD1_k127_7550613_5	485914.Hmuk_0968	1.124e-64	242.0	COG1226@1|root,arCOG01960@2157|Archaea,2XTQV@28890|Euryarchaeota,23SJZ@183963|Halobacteria	183963|Halobacteria	P	COG1226 Kef-type K transport systems	trk	-	-	-	-	-	-	-	-	-	-	-	TrkA_C,TrkA_N
HKD1_k127_7550613_19	589924.Ferp_2252	6.902e-09	59.0	COG4068@1|root,arCOG04390@2157|Archaea,2Y64Z@28890|Euryarchaeota,247EZ@183980|Archaeoglobi	183980|Archaeoglobi	S	Uncharacterized protein containing a Zn-ribbon (DUF2116)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2116
HKD1_k127_7550613_20	762903.Pedsa_3644	8.393e-09	68.0	COG3420@1|root,COG3420@2|Bacteria,4NEGT@976|Bacteroidetes,1IRBN@117747|Sphingobacteriia	976|Bacteroidetes	P	PFAM Periplasmic copper-binding protein (NosD)	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD1_k127_7550613_23	1345697.M493_10660	0.0001389	55.0	COG3420@1|root,COG3420@2|Bacteria,1UN63@1239|Firmicutes,4HAZN@91061|Bacilli,1WFE8@129337|Geobacillus	91061|Bacilli	P	Periplasmic copper-binding protein (NosD)	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD1_k127_7550613_4	351160.RCIX1545	3.022e-69	239.0	COG0503@1|root,arCOG00030@2157|Archaea,2XTWM@28890|Euryarchaeota,2N9KI@224756|Methanomicrobia	224756|Methanomicrobia	F	Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis	hpt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	iAF692.Mbar_A1633	Pribosyltran
HKD1_k127_7550613_13	224325.AF_1782	9.818e-21	94.0	COG1849@1|root,arCOG01224@2157|Archaea,2Y0U9@28890|Euryarchaeota,246GR@183980|Archaeoglobi	183980|Archaeoglobi	S	Protein of unknown function (DUF357)	-	-	-	ko:K09728	-	-	-	-	ko00000	-	-	-	DUF357
HKD1_k127_7550613_8	304371.MCP_0215	1.157e-41	162.0	COG2085@1|root,arCOG00457@2157|Archaea,2XUD2@28890|Euryarchaeota,2N9SI@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD1_k127_7550613_16	1038866.KB902784_gene4665	2.187e-15	78.0	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_7550613_10	1163730.FFONT_0332	1.287e-24	114.0	COG1750@1|root,arCOG01937@2157|Archaea,2XQAW@28889|Crenarchaeota	28889|Crenarchaeota	O	PFAM Lon protease (S16) C-terminal proteolytic domain	-	-	-	ko:K06870	-	-	-	-	ko00000	-	-	-	Lon_C
HKD1_k127_7550613_14	290318.Cvib_1427	6.769e-18	85.0	COG3476@1|root,COG3476@2|Bacteria,1FF76@1090|Chlorobi	1090|Chlorobi	T	PFAM TspO MBR family protein	-	GO:0003674,GO:0005488,GO:0005575,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033013,GO:0044237,GO:0044425,GO:0046483,GO:0046906,GO:0071704,GO:0097159,GO:1901360,GO:1901363,GO:1901564	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD1_k127_7550613_17	192952.MM_0963	6.146e-15	78.0	COG3476@1|root,arCOG04434@2157|Archaea,2XYQD@28890|Euryarchaeota,2NAZX@224756|Methanomicrobia	224756|Methanomicrobia	T	TspO/MBR family	-	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD1_k127_7550613_9	2074.JNYD01000046_gene7304	2.132e-33	137.0	COG0477@1|root,COG0477@2|Bacteria,2GITS@201174|Actinobacteria,4DYCA@85010|Pseudonocardiales	201174|Actinobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7550613_24	1118235.CAJH01000020_gene1219	0.0006183	48.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,1S1VS@1236|Gammaproteobacteria,1X3R3@135614|Xanthomonadales	135614|Xanthomonadales	S	virion core protein (lumpy skin disease virus)	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1
HKD1_k127_7550613_3	439481.Aboo_1400	1.2e-71	254.0	COG1506@1|root,arCOG01646@2157|Archaea	2157|Archaea	E	Peptidase S9 prolyl oligopeptidase active site	-	-	3.4.14.11	ko:K01281	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_7550613_22	472759.Nhal_3096	6.915e-08	55.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria,1WXNN@135613|Chromatiales	135613|Chromatiales	F	PFAM glycosyl transferase family 35	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_7550613_21	1406840.Q763_00340	8.46e-09	68.0	COG1409@1|root,COG3540@1|root,COG1409@2|Bacteria,COG3540@2|Bacteria,4NJT0@976|Bacteroidetes,1I0D5@117743|Flavobacteriia,2NSST@237|Flavobacterium	976|Bacteroidetes	P	Purple acid Phosphatase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Pur_ac_phosph_N
HKD1_k127_7550613_18	269797.Mbar_A1800	4.643e-12	79.0	COG1520@1|root,COG3291@1|root,arCOG02550@1|root,arCOG03991@1|root,arCOG02482@2157|Archaea,arCOG02510@2157|Archaea,arCOG02550@2157|Archaea,arCOG03991@2157|Archaea,2XUI1@28890|Euryarchaeota,2NBKW@224756|Methanomicrobia	2157|Archaea	S	Periplasmic copper-binding protein (NosD)	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,CBM_6,DUF3344,NosD,PKD,PQQ_2,PQQ_3,Pkinase
HKD1_k127_7550613_1	647113.Metok_1325	2.373e-103	349.0	COG0477@1|root,arCOG00130@2157|Archaea,2XU3E@28890|Euryarchaeota,23QKI@183939|Methanococci	183939|Methanococci	G	PFAM Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7550613_7	1123284.KB899042_gene1343	1.186e-51	186.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,4HKIA@91061|Bacilli,26PZ3@186821|Sporolactobacillaceae	91061|Bacilli	M	Large-conductance mechanosensitive channel, MscL	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_7550613_0	1313172.YM304_27660	2.249e-220	708.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
HKD1_k127_7550613_12	269797.Mbar_A3219	8.835e-23	100.0	arCOG04958@1|root,arCOG04958@2157|Archaea,2Y0MG@28890|Euryarchaeota,2N9YS@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7550613_2	1094980.Mpsy_1047	5.692e-83	282.0	COG1842@1|root,arCOG04782@2157|Archaea,2XU11@28890|Euryarchaeota,2N9P1@224756|Methanomicrobia	224756|Methanomicrobia	K	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD1_k127_7559821_2	1188252.AJYK01000016_gene1805	1.822e-44	171.0	COG0657@1|root,COG0657@2|Bacteria,1N5QB@1224|Proteobacteria,1RS7Q@1236|Gammaproteobacteria,1XYZ8@135623|Vibrionales	135623|Vibrionales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD1_k127_7559821_0	1210908.HSB1_21250	3.189e-98	329.0	COG1266@1|root,arCOG02768@2157|Archaea,2XU8T@28890|Euryarchaeota,23U5H@183963|Halobacteria	183963|Halobacteria	S	metal-dependent membrane protease	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_7559821_5	485916.Dtox_2171	0.0001765	46.0	COG2020@1|root,COG2020@2|Bacteria,1W16J@1239|Firmicutes	1239|Firmicutes	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU
HKD1_k127_7559821_6	1123278.KB893552_gene3740	0.0003855	43.0	COG2020@1|root,COG2020@2|Bacteria,4NTXI@976|Bacteroidetes,47RFP@768503|Cytophagia	976|Bacteroidetes	O	NnrU protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
HKD1_k127_7559821_4	429009.Adeg_1940	1.048e-18	89.0	COG0640@1|root,COG0640@2|Bacteria,1V6CU@1239|Firmicutes,24R9E@186801|Clostridia,42H4C@68295|Thermoanaerobacterales	186801|Clostridia	K	PFAM regulatory protein, ArsR	-	-	-	ko:K03892,ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_7559821_1	679926.Mpet_0354	3.798e-98	331.0	COG0701@1|root,arCOG02712@2157|Archaea,2XVVT@28890|Euryarchaeota,2N9A7@224756|Methanomicrobia	224756|Methanomicrobia	S	Predicted permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD1_k127_7559821_3	1094980.Mpsy_2097	1.249e-34	144.0	COG0526@1|root,COG0785@1|root,arCOG01972@2157|Archaea,arCOG02404@2157|Archaea,2Y7HT@28890|Euryarchaeota,2NA19@224756|Methanomicrobia	224756|Methanomicrobia	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
HKD1_k127_758961_4	1094980.Mpsy_1517	2.499e-84	282.0	COG2101@1|root,arCOG01764@2157|Archaea,2XTTR@28890|Euryarchaeota,2N9N0@224756|Methanomicrobia	224756|Methanomicrobia	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	tbpE	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
HKD1_k127_758961_3	192952.MM_2061	1.587e-126	419.0	COG0124@1|root,arCOG00404@2157|Archaea,2XSYX@28890|Euryarchaeota,2N9BW@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_758961_10	178306.PAE1316	8.539e-07	55.0	arCOG02718@1|root,arCOG02718@2157|Archaea	2157|Archaea	S	TIGRFAM TIGR00304 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF131
HKD1_k127_758961_2	1094980.Mpsy_1726	3.167e-146	479.0	COG1311@1|root,arCOG04455@2157|Archaea,2XSUG@28890|Euryarchaeota,2N96N@224756|Methanomicrobia	224756|Methanomicrobia	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polB	-	2.7.7.7	ko:K02323	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	DNA_pol_E_B,Metallophos,tRNA_anti-codon
HKD1_k127_758961_7	1094980.Mpsy_1727	5.095e-45	172.0	COG0681@1|root,arCOG01739@2157|Archaea,2XU45@28890|Euryarchaeota,2N9SB@224756|Methanomicrobia	224756|Methanomicrobia	U	TIGRFAM peptidase S26B, signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_758961_6	1094980.Mpsy_1937	8.966e-63	223.0	COG0513@1|root,arCOG00078@2157|Archaea,2XTFM@28890|Euryarchaeota,2N9QB@224756|Methanomicrobia	224756|Methanomicrobia	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
HKD1_k127_758961_5	351160.RRC178	1.398e-63	220.0	COG0864@1|root,arCOG01008@2157|Archaea,2XWHW@28890|Euryarchaeota,2N9KS@224756|Methanomicrobia	224756|Methanomicrobia	K	Transcriptional regulator	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD1_k127_758961_8	192952.MM_1412	2.499e-39	154.0	arCOG04998@1|root,arCOG04998@2157|Archaea,2XZR1@28890|Euryarchaeota,2N9VB@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_758961_9	289376.THEYE_A0025	2.744e-26	119.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	uspA	GO:0000302,GO:0000303,GO:0000305,GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006970,GO:0006979,GO:0007154,GO:0008150,GO:0009267,GO:0009314,GO:0009411,GO:0009416,GO:0009605,GO:0009628,GO:0009651,GO:0009987,GO:0009991,GO:0010035,GO:0031667,GO:0031668,GO:0031669,GO:0032947,GO:0033554,GO:0034644,GO:0042221,GO:0042594,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051716,GO:0071214,GO:0071478,GO:0071482,GO:0071496,GO:0104004,GO:1901700	-	ko:K06149,ko:K14064,ko:K14065	-	-	-	-	ko00000	-	-	-	Usp
HKD1_k127_758961_0	690850.Desaf_3637	9.303e-185	593.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,42MSA@68525|delta/epsilon subdivisions,2WIS1@28221|Deltaproteobacteria,2M92C@213115|Desulfovibrionales	28221|Deltaproteobacteria	CP	PFAM NADH Ubiquinone plastoquinone (complex I)	-	-	-	ko:K05568,ko:K12137	-	-	-	-	ko00000,ko01000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD1_k127_758961_11	1085623.GNIT_1153	7.137e-06	53.0	2EAIM@1|root,334MN@2|Bacteria,1N6XM@1224|Proteobacteria,1SF6C@1236|Gammaproteobacteria,469A2@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_758961_1	565033.GACE_0448	2.607e-148	481.0	COG0651@1|root,arCOG01541@2157|Archaea,2XTUI@28890|Euryarchaeota,2460E@183980|Archaeoglobi	183980|Archaeoglobi	C	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_7592955_0	323259.Mhun_1670	2.541e-30	133.0	arCOG04442@1|root,arCOG04442@2157|Archaea,2XXCX@28890|Euryarchaeota,2NASK@224756|Methanomicrobia	224756|Methanomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_7602922_1	387631.Asulf_00604	6.162e-69	240.0	COG0365@1|root,arCOG01529@2157|Archaea,2XTAB@28890|Euryarchaeota,246QT@183980|Archaeoglobi	183980|Archaeoglobi	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_7602922_0	1220534.B655_1663	7.037e-85	290.0	COG0122@1|root,arCOG00464@2157|Archaea,2XV7J@28890|Euryarchaeota	28890|Euryarchaeota	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_7602922_3	399550.Smar_0566	1.067e-31	128.0	COG4315@1|root,arCOG08235@2157|Archaea	2157|Archaea	C	PFAM Secreted repeat of	-	-	-	-	-	-	-	-	-	-	-	-	Lipoprotein_15
HKD1_k127_7602922_4	192952.MM_0760	0.0001416	44.0	COG1145@1|root,arCOG01610@2157|Archaea,2Y1GK@28890|Euryarchaeota,2NA40@224756|Methanomicrobia	224756|Methanomicrobia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_7602922_2	1027292.HMPREF9372_3129	6.372e-40	158.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,4HC54@91061|Bacilli,26EQJ@186818|Planococcaceae	91061|Bacilli	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_7639023_1	410358.Mlab_0190	7.169e-16	78.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota	28890|Euryarchaeota	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_7639023_0	1229909.NSED_03185	1.468e-16	85.0	arCOG03727@1|root,arCOG03727@2157|Archaea,41STD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mrr_cat
HKD1_k127_7639023_3	1121904.ARBP01000017_gene5073	2.069e-06	59.0	COG1858@1|root,COG2273@1|root,COG3391@1|root,COG3401@1|root,COG4733@1|root,COG5276@1|root,COG5492@1|root,COG1858@2|Bacteria,COG2273@2|Bacteria,COG3391@2|Bacteria,COG3401@2|Bacteria,COG4733@2|Bacteria,COG5276@2|Bacteria,COG5492@2|Bacteria,4NIPP@976|Bacteroidetes,47JEG@768503|Cytophagia	976|Bacteroidetes	C	PKD domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CBM_3,Cytochrom_C,Cytochrom_D1,PKD
HKD1_k127_7639023_2	679926.Mpet_0936	3.747e-09	68.0	arCOG03601@1|root,arCOG03601@2157|Archaea,2Y0JT@28890|Euryarchaeota,2NA2N@224756|Methanomicrobia	224756|Methanomicrobia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_7651024_1	192952.MM_0949	2.577e-33	141.0	arCOG02083@1|root,arCOG02083@2157|Archaea,2Y2FI@28890|Euryarchaeota,2NA9F@224756|Methanomicrobia	224756|Methanomicrobia	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7651024_0	1123511.KB905839_gene595	5.013e-76	261.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4H22T@909932|Negativicutes	909932|Negativicutes	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7651024_2	1208323.B30_12642	0.0002602	51.0	COG2911@1|root,COG2911@2|Bacteria,1P8N9@1224|Proteobacteria,2TXN3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_3,DUF4347
HKD1_k127_7655446_1	653733.Selin_1594	1.714e-22	97.0	COG0188@1|root,COG0188@2|Bacteria	2|Bacteria	L	DNA topoisomerase II activity	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_7655446_0	1449126.JQKL01000061_gene1910	1.717e-207	654.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,2682S@186813|unclassified Clostridiales	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_7689571_2	867903.ThesuDRAFT_01017	1.562e-12	70.0	COG1479@1|root,COG3472@1|root,COG1479@2|Bacteria,COG3472@2|Bacteria,1TQ81@1239|Firmicutes,24BX6@186801|Clostridia	186801|Clostridia	S	Conserved protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF262
HKD1_k127_7689571_1	279714.FuraDRAFT_3407	1.542e-12	72.0	2DMKI@1|root,32S70@2|Bacteria,1N1FV@1224|Proteobacteria,2W55V@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
HKD1_k127_7689571_3	192952.MM_2869	2.302e-10	63.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y2AR@28890|Euryarchaeota,2NA7W@224756|Methanomicrobia	224756|Methanomicrobia	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
HKD1_k127_7689571_0	1094980.Mpsy_0307	1.122e-29	124.0	COG2020@1|root,arCOG03580@2157|Archaea,2Y2AR@28890|Euryarchaeota,2NA7W@224756|Methanomicrobia	224756|Methanomicrobia	O	NnrU protein	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU
HKD1_k127_7747371_0	65393.PCC7424_2578	8.476e-43	168.0	COG3187@1|root,COG3187@2|Bacteria,1G96Y@1117|Cyanobacteria,3KHY5@43988|Cyanothece	1117|Cyanobacteria	O	META domain	-	-	-	ko:K03668	-	-	-	-	ko00000	-	-	-	DUF4377,META
HKD1_k127_7769545_5	1220534.B655_1409	3.366e-12	69.0	COG2041@1|root,arCOG00266@2157|Archaea	2157|Archaea	P	COG2041 Sulfite oxidase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
HKD1_k127_7769545_4	1343739.PAP_08585	7.405e-41	165.0	COG4902@1|root,arCOG03957@2157|Archaea,2XX05@28890|Euryarchaeota,243QP@183968|Thermococci	183968|Thermococci	S	Uncharacterized protein domain (DUF2202)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2202
HKD1_k127_7769545_2	523850.TON_0876	6.751e-53	201.0	arCOG07677@1|root,arCOG07677@2157|Archaea,2XWVM@28890|Euryarchaeota,244MD@183968|Thermococci	183968|Thermococci	S	Possible catecholamine-binding domain present in a variety of eukaryotic proteins.	-	-	-	-	-	-	-	-	-	-	-	-	DOMON
HKD1_k127_7769545_0	304371.MCP_1358	3.702e-150	496.0	COG0175@1|root,COG2221@1|root,arCOG00073@2157|Archaea,arCOG02059@2157|Archaea,2Y7JD@28890|Euryarchaeota,2N9AR@224756|Methanomicrobia	224756|Methanomicrobia	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_10,PAPS_reduct
HKD1_k127_7769545_1	351160.RCIX1287	3.667e-75	260.0	COG2520@1|root,arCOG00033@2157|Archaea,2XXP0@28890|Euryarchaeota,2N9KF@224756|Methanomicrobia	224756|Methanomicrobia	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
HKD1_k127_7769545_3	368407.Memar_1663	1.865e-49	183.0	COG1628@1|root,arCOG00928@2157|Archaea,2XXBV@28890|Euryarchaeota,2N9K3@224756|Methanomicrobia	224756|Methanomicrobia	L	Belongs to the UPF0215 family	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
HKD1_k127_7796487_2	457421.CBFG_05994	6.031e-13	71.0	COG2159@1|root,COG2159@2|Bacteria,1V0UC@1239|Firmicutes,24ER8@186801|Clostridia,26BHV@186813|unclassified Clostridiales	186801|Clostridia	S	Amidohydrolase	-	-	-	ko:K07045	-	-	-	-	ko00000	-	-	-	Amidohydro_2
HKD1_k127_7796487_0	192952.MM_1626	4.269e-110	364.0	COG2516@1|root,arCOG00662@2157|Archaea,2XV52@28890|Euryarchaeota,2N9EK@224756|Methanomicrobia	224756|Methanomicrobia	S	Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_7796487_1	1384057.CD33_02430	4.72e-16	83.0	2AJCU@1|root,344IW@2|Bacteria,1W0VJ@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7804006_1	1396418.BATQ01000008_gene1492	5.958e-09	68.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7804006_0	670307.HYPDE_29913	8.599e-10	68.0	COG2218@1|root,COG2218@2|Bacteria,1MUUQ@1224|Proteobacteria,2U51Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM glutamate synthase alpha subunit domain protein	fhcC	GO:0006730,GO:0008150,GO:0008152,GO:0009987,GO:0044237,GO:0044281	1.2.7.12	ko:K00202	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	GXGXG
HKD1_k127_7804006_2	243274.THEMA_08685	1.306e-05	57.0	COG0714@1|root,COG0714@2|Bacteria,2GC2Y@200918|Thermotogae	200918|Thermotogae	S	associated with various cellular activities	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_7804006_3	97096.XP_007795438.1	0.0005437	49.0	COG0531@1|root,KOG1286@2759|Eukaryota,38DMK@33154|Opisthokonta,3NUN0@4751|Fungi,3QJHC@4890|Ascomycota,217D3@147550|Sordariomycetes	4751|Fungi	E	proline permease	-	-	-	ko:K16261	-	-	-	-	ko00000,ko02000	2.A.3.10	-	-	AA_permease
HKD1_k127_7806774_1	1094980.Mpsy_0224	8.835e-25	106.0	COG4871@1|root,arCOG00297@2157|Archaea,2XZDM@28890|Euryarchaeota,2NAB0@224756|Methanomicrobia	224756|Methanomicrobia	K	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS,HTH_20
HKD1_k127_7806774_0	593750.Metfor_2721	1.904e-147	474.0	COG0798@1|root,arCOG02190@2157|Archaea,2XTQC@28890|Euryarchaeota,2N935@224756|Methanomicrobia	224756|Methanomicrobia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD1_k127_7806774_2	436308.Nmar_0680	2.553e-21	106.0	COG2897@1|root,arCOG02019@2157|Archaea,41SBN@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_7806774_3	192952.MM_2246	2.322e-14	74.0	COG0640@1|root,arCOG01681@2157|Archaea,2XYSN@28890|Euryarchaeota,2NBKM@224756|Methanomicrobia	224756|Methanomicrobia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_7861105_1	906968.Trebr_1367	3.909e-07	60.0	COG0727@1|root,COG0727@2|Bacteria,2J85V@203691|Spirochaetes	203691|Spirochaetes	S	PFAM Uncharacterised protein family (UPF0153)	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_7861105_0	1094980.Mpsy_2182	1.135e-24	105.0	COG1962@1|root,arCOG04336@2157|Archaea,2XV9A@28890|Euryarchaeota,2N996@224756|Methanomicrobia	224756|Methanomicrobia	H	PFAM Tetrahydromethanopterin S-methyltransferase MtrH subunit	mtrH	-	2.1.1.86	ko:K00584	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrH
HKD1_k127_801635_0	933262.AXAM01000025_gene3431	2.669e-42	165.0	COG1413@1|root,COG1413@2|Bacteria,1QCWA@1224|Proteobacteria,42M5W@68525|delta/epsilon subdivisions,2WM1Q@28221|Deltaproteobacteria,2MI9I@213118|Desulfobacterales	28221|Deltaproteobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_820516_3	795359.TOPB45_1009	5.736e-17	87.0	COG0071@1|root,COG0071@2|Bacteria,2GHTW@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_820516_4	981369.JQMJ01000004_gene397	1.227e-15	83.0	COG4803@1|root,COG4803@2|Bacteria,2IIN1@201174|Actinobacteria,2NJ0B@228398|Streptacidiphilus	201174|Actinobacteria	S	membrane protein of uknown function UCP014873	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
HKD1_k127_820516_2	1108045.GORHZ_164_00520	1.709e-17	85.0	2E35Q@1|root,32Y5M@2|Bacteria,2GS2Q@201174|Actinobacteria,4GF0S@85026|Gordoniaceae	201174|Actinobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
HKD1_k127_820516_0	1041930.Mtc_2052	5.734e-50	181.0	COG1852@1|root,arCOG02078@2157|Archaea,2XWB4@28890|Euryarchaeota,2N9TJ@224756|Methanomicrobia	224756|Methanomicrobia	S	Protein of unknown function DUF116	-	-	-	ko:K09729	-	-	-	-	ko00000	-	-	-	DUF116
HKD1_k127_840646_1	1034345.CAEM01000023_gene834	5.38e-66	233.0	COG0543@1|root,COG0543@2|Bacteria,2HXFY@201174|Actinobacteria,4CV8F@84998|Coriobacteriia	84998|Coriobacteriia	C	Oxidoreductase NAD-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD1_k127_840646_0	269797.Mbar_A0488	8.659e-87	297.0	COG0517@1|root,arCOG00600@2157|Archaea,2XU4J@28890|Euryarchaeota,2N994@224756|Methanomicrobia	224756|Methanomicrobia	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_840646_2	269797.Mbar_A0487	3.781e-33	133.0	COG0589@1|root,arCOG02053@2157|Archaea,2XX8Y@28890|Euryarchaeota,2N9XS@224756|Methanomicrobia	28890|Euryarchaeota	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_840646_3	269797.Mbar_A0486	1.006e-14	76.0	COG0402@1|root,arCOG00692@2157|Archaea,2XSYB@28890|Euryarchaeota,2N9II@224756|Methanomicrobia	224756|Methanomicrobia	F	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase,Amidohydro_1
HKD1_k127_934398_4	304371.MCP_0172	1.133e-20	95.0	COG0438@1|root,arCOG01403@2157|Archaea,2XTRH@28890|Euryarchaeota	28890|Euryarchaeota	M	PFAM Glycosyl transferase, group 1	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_934398_0	269797.Mbar_A0296	6.649e-201	641.0	arCOG04922@1|root,arCOG04922@2157|Archaea,2XW4K@28890|Euryarchaeota,2NAJ7@224756|Methanomicrobia	224756|Methanomicrobia	M	Glycogen synthase	-	-	-	-	-	-	-	-	-	-	-	iAF692.Mbar_A0296	Glycogen_syn
HKD1_k127_934398_3	1094980.Mpsy_2818	1.976e-71	250.0	COG0467@1|root,arCOG01171@2157|Archaea	2157|Archaea	T	Circadian clock protein KaiC	-	-	-	-	-	-	-	-	-	-	-	-	ATPase
HKD1_k127_934398_2	368408.Tpen_0135	1.362e-132	439.0	COG1449@1|root,arCOG03278@2157|Archaea,2XQ1R@28889|Crenarchaeota	28889|Crenarchaeota	G	Belongs to the glycosyl hydrolase 57 family	-	-	3.2.1.1	ko:K07405	ko00500,ko01100,map00500,map01100	-	R02108,R02112,R11262	-	ko00000,ko00001,ko01000	-	GH57	-	Glyco_hydro_57
HKD1_k127_934398_1	192952.MM_2380	1.054e-142	466.0	COG1202@1|root,arCOG00554@2157|Archaea,2XUCK@28890|Euryarchaeota,2N92E@224756|Methanomicrobia	224756|Methanomicrobia	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03725	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,Helicase_C
HKD1_k127_954206_1	1232437.KL662018_gene589	3.977e-32	134.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,42T6P@68525|delta/epsilon subdivisions,2X5AV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_954206_0	593750.Metfor_0988	5.756e-59	213.0	COG1226@1|root,arCOG01964@2157|Archaea,2Y19J@28890|Euryarchaeota,2NADN@224756|Methanomicrobia	224756|Methanomicrobia	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans
HKD1_k127_95816_0	192952.MM_0121	1.911e-155	496.0	COG1151@1|root,arCOG02429@2157|Archaea,2XWFM@28890|Euryarchaeota,2NAM1@224756|Methanomicrobia	224756|Methanomicrobia	C	Prismane/CO dehydrogenase family	-	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3525	Prismane
HKD1_k127_95816_1	1041930.Mtc_0345	1.851e-140	455.0	COG0297@1|root,arCOG01420@2157|Archaea,2Y8C8@28890|Euryarchaeota,2NBP8@224756|Methanomicrobia	2157|Archaea	M	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_95816_2	269797.Mbar_A0295	4.616e-83	287.0	COG1085@1|root,arCOG00422@2157|Archaea,2XXR5@28890|Euryarchaeota,2N9KB@224756|Methanomicrobia	224756|Methanomicrobia	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4921,GalP_UDP_transf
HKD1_k127_95816_3	1041930.Mtc_0555	5.724e-05	46.0	COG0297@1|root,arCOG01420@2157|Archaea,2Y8C8@28890|Euryarchaeota	2157|Archaea	M	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_9770_5	932678.THERU_02135	2.053e-33	132.0	COG2346@1|root,COG2346@2|Bacteria,2G5AF@200783|Aquificae	200783|Aquificae	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD1_k127_9770_2	1094980.Mpsy_1597	6.87e-57	207.0	COG0500@1|root,arCOG01780@2157|Archaea	2157|Archaea	Q	COG0500 SAM-dependent methyltransferases	pcm3	-	-	ko:K17462	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00609	R10404	RC00003	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_9770_6	331678.Cphamn1_0767	0.000158	45.0	COG0415@1|root,COG0415@2|Bacteria	2|Bacteria	L	Belongs to the DNA photolyase family	phr	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD1_k127_9770_1	351160.RRC408	3.719e-111	367.0	COG1184@1|root,arCOG01124@2157|Archaea,2XUFM@28890|Euryarchaeota,2N97Y@224756|Methanomicrobia	224756|Methanomicrobia	J	Belongs to the eIF-2B alpha beta delta subunits family	-	-	5.3.1.29	ko:K18237	-	-	-	-	ko00000,ko01000	-	-	-	IF-2B
HKD1_k127_9770_3	1121413.JMKT01000002_gene2641	3.803e-43	162.0	COG0655@1|root,COG0655@2|Bacteria,1QV9P@1224|Proteobacteria,42RJT@68525|delta/epsilon subdivisions,2WNM5@28221|Deltaproteobacteria,2MGKQ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Flavodoxin domain	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD1_k127_9770_0	192952.MM_2866	7.898e-239	747.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_9770_4	443143.GM18_2383	1.83e-37	146.0	2BHPS@1|root,32BT1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_983515_7	596151.DesfrDRAFT_0807	0.0002447	49.0	2ENSS@1|root,33GDX@2|Bacteria,1PAMM@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_983515_3	456442.Mboo_1254	3.289e-14	79.0	arCOG07763@1|root,arCOG07763@2157|Archaea	2157|Archaea	L	DNA polymerase activity	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	-
HKD1_k127_983515_5	756883.Halar_1398	3.969e-08	56.0	arCOG08018@1|root,arCOG14522@2157|Archaea	2157|Archaea	S	UPF0391 membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1328
HKD1_k127_983515_1	868131.MSWAN_0613	5.736e-19	89.0	arCOG11305@1|root,arCOG11305@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_983515_0	192952.MM_1981	2.656e-26	112.0	COG1153@1|root,arCOG02674@2157|Archaea,2XXYM@28890|Euryarchaeota,2NB08@224756|Methanomicrobia	224756|Methanomicrobia	C	PFAM molydopterin dinucleotide-binding region	fwdD-1	-	1.2.7.12	ko:K00203	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00567	R03015,R08060,R11743	RC00197,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Molydop_binding
HKD1_k127_983515_6	243231.GSU1926	1.689e-06	53.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,42X7G@68525|delta/epsilon subdivisions,2WSX9@28221|Deltaproteobacteria,43VJC@69541|Desulfuromonadales	28221|Deltaproteobacteria	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NnrU,PEMT
HKD1_k127_983515_2	760568.Desku_0877	7.574e-15	79.0	COG2411@1|root,COG2411@2|Bacteria	2|Bacteria	-	-	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	ASCH
HKD1_k127_983515_4	635013.TherJR_0525	3.326e-10	62.0	COG0427@1|root,COG1670@1|root,COG0427@2|Bacteria,COG1670@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,260IW@186807|Peptococcaceae	186801|Clostridia	C	PFAM Acetyl-CoA hydrolase transferase	cat	-	-	ko:K18122	ko00650,ko01100,ko01200,map00650,map01100,map01200	-	R05336	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
## 1964 queries scanned
## Total time (seconds): 49.25240635871887
## Rate: 39.88 q/s