## Wed Oct 16 20:33:44 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/Potential_rubisco_autotrophic/HKD1_bin.74.fa -m mmseqs --itype genome -o HKD1_bin.74 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/all_bins_1385/HKD1_bin.74 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1017316_8	670487.Ocepr_2146	4.605e-10	66.0	29Y13@1|root,30JU0@2|Bacteria,1WKT1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1017316_3	592015.HMPREF1705_02026	4.219e-59	212.0	COG0778@1|root,COG0778@2|Bacteria,3TCD8@508458|Synergistetes	508458|Synergistetes	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_1017316_5	472759.Nhal_3775	1.463e-31	128.0	COG4274@1|root,COG4274@2|Bacteria,1N83R@1224|Proteobacteria,1ST4N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_1017316_6	665571.STHERM_c12220	7.701e-22	100.0	COG2703@1|root,COG2703@2|Bacteria,2J7CC@203691|Spirochaetes	203691|Spirochaetes	P	Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HKD1_k127_1017316_4	1121033.AUCF01000027_gene2775	1.602e-44	167.0	COG0680@1|root,COG0680@2|Bacteria,1RE1C@1224|Proteobacteria,2U2IN@28211|Alphaproteobacteria,2JT4C@204441|Rhodospirillales	204441|Rhodospirillales	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD1_k127_1017316_0	1163617.SCD_n00764	4.928e-274	852.0	COG0374@1|root,COG0374@2|Bacteria,1MWFJ@1224|Proteobacteria,2VJ52@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hybC	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_1017316_1	156889.Mmc1_2504	3.345e-123	405.0	COG5557@1|root,COG5557@2|Bacteria,1MWYI@1224|Proteobacteria,2U4H3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_1017316_2	765911.Thivi_3937	4.675e-107	356.0	COG0437@1|root,COG0437@2|Bacteria,1MU1B@1224|Proteobacteria,1RPF5@1236|Gammaproteobacteria,1X25M@135613|Chromatiales	135613|Chromatiales	C	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11
HKD1_k127_1017316_7	1121033.AUCF01000027_gene2779	8.01e-17	83.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria,2JQIC@204441|Rhodospirillales	204441|Rhodospirillales	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD1_k127_105387_3	1337936.IJ00_19125	1.669e-60	211.0	COG0635@1|root,COG0635@2|Bacteria,1G0BZ@1117|Cyanobacteria,1HKQT@1161|Nostocales	1117|Cyanobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_105387_1	1380355.JNIJ01000068_gene5655	6.78e-181	617.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,2TRIX@28211|Alphaproteobacteria,3K05Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TIR_2,WD40
HKD1_k127_105387_2	1049564.TevJSym_an00600	2.483e-97	327.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,1RNTY@1236|Gammaproteobacteria,1J543@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0033036,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051234,GO:0071702,GO:0071705,GO:0071944	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_105387_0	1026882.MAMP_01702	1.718e-218	694.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,1RMIQ@1236|Gammaproteobacteria,45ZN8@72273|Thiotrichales	72273|Thiotrichales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD-TM1,SecD_SecF,Sec_GG
HKD1_k127_105387_4	314278.NB231_00650	8.32e-36	138.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1WYM1@135613|Chromatiales	135613|Chromatiales	U	TIGRFAM preprotein translocase, YajC subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD1_k127_105387_5	1266908.AQPB01000059_gene2601	2.151e-18	86.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_1067767_8	63737.Npun_F0403	4.071e-45	173.0	COG3209@1|root,COG3584@1|root,COG3209@2|Bacteria,COG3584@2|Bacteria,1GB8C@1117|Cyanobacteria	1117|Cyanobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1067767_3	1049564.TevJSym_bc00190	4.235e-117	386.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,1RMWD@1236|Gammaproteobacteria,1J56S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0008932,GO:0008933,GO:0016020,GO:0016021,GO:0016740,GO:0016757,GO:0030203,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0042597,GO:0043170,GO:0044425,GO:0044459,GO:0044464,GO:0061783,GO:0071704,GO:0071944,GO:1901135,GO:1901564	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD1_k127_1067767_4	65393.PCC7424_3047	8.149e-95	313.0	COG0693@1|root,COG0693@2|Bacteria,1G2Z5@1117|Cyanobacteria,3KKMN@43988|Cyanothece	1117|Cyanobacteria	S	PFAM ThiJ PfpI domain protein	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD1_k127_1067767_2	883126.HMPREF9710_01064	1.529e-232	734.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VJG4@28216|Betaproteobacteria,4724T@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_1067767_9	1122194.AUHU01000013_gene745	1.051e-26	111.0	COG2974@1|root,COG2974@2|Bacteria,1MXPR@1224|Proteobacteria,1RMNN@1236|Gammaproteobacteria,4650K@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	May be involved in recombination	rdgC	GO:0000018,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003697,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009295,GO:0019219,GO:0019222,GO:0031323,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043590,GO:0044424,GO:0044444,GO:0044464,GO:0050789,GO:0050794,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:1901363	-	ko:K03554	-	-	-	-	ko00000,ko03400	-	-	-	RdgC
HKD1_k127_1067767_1	1288494.EBAPG3_25850	1.007e-257	827.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VJMN@28216|Betaproteobacteria,372EE@32003|Nitrosomonadales	28216|Betaproteobacteria	T	Double sensory domain of two-component sensor kinase	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISM_7TM,EAL,GGDEF,PAS,PAS_4,dCache_3
HKD1_k127_1067767_7	338966.Ppro_2603	1.626e-51	185.0	COG2050@1|root,COG2050@2|Bacteria,1RGVP@1224|Proteobacteria,42U6X@68525|delta/epsilon subdivisions,2WQZA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	3.1.2.28	ko:K19222	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07262	RC00004,RC00174	ko00000,ko00001,ko00002,ko01000	-	-	-	4HBT
HKD1_k127_1067767_5	395494.Galf_1256	1.549e-79	274.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2VHF4@28216|Betaproteobacteria,44VAT@713636|Nitrosomonadales	28216|Betaproteobacteria	J	Specifically methylates the ribose of guanosine 2251 in 23S rRNA	rlmB	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD1_k127_1067767_0	519989.ECTPHS_00450	4.659e-305	951.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,1RMQE@1236|Gammaproteobacteria,1WXF0@135613|Chromatiales	135613|Chromatiales	K	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HTH_12,OB_RNB,RNB,S1
HKD1_k127_1067767_6	177437.HRM2_42930	1.464e-55	206.0	COG2358@1|root,COG2358@2|Bacteria,1MWSG@1224|Proteobacteria,42NC8@68525|delta/epsilon subdivisions,2WK4Q@28221|Deltaproteobacteria,2MIAT@213118|Desulfobacterales	28221|Deltaproteobacteria	S	NMT1-like family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD1_k127_1067767_10	313595.P700755_001641	8.007e-26	108.0	2DNS7@1|root,32YWC@2|Bacteria,4NSJ6@976|Bacteroidetes	976|Bacteroidetes	S	S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_1076598_3	713587.THITH_08675	7.974e-143	457.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1WWIR@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1076598_21	765911.Thivi_3359	8.231e-35	140.0	COG0639@1|root,COG0639@2|Bacteria,1N394@1224|Proteobacteria,1SC78@1236|Gammaproteobacteria,1WZ0C@135613|Chromatiales	135613|Chromatiales	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HKD1_k127_1076598_0	187272.Mlg_1865	0.0	1062.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,1RN5T@1236|Gammaproteobacteria,1WWDB@135613|Chromatiales	135613|Chromatiales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,DUF294,GlnD_UR_UTase,HD,NTP_transf_2
HKD1_k127_1076598_4	323261.Noc_0807	1.322e-132	427.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,1RMHN@1236|Gammaproteobacteria,1WX9V@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_1076598_8	765914.ThisiDRAFT_1080	3.501e-114	374.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,1RN0Z@1236|Gammaproteobacteria,1WW47@135613|Chromatiales	135613|Chromatiales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_1076598_11	396588.Tgr7_1160	1.682e-109	361.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,1RPBJ@1236|Gammaproteobacteria,1WXRN@135613|Chromatiales	135613|Chromatiales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD1_k127_1076598_9	396588.Tgr7_1161	2.894e-111	364.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,1RMHX@1236|Gammaproteobacteria,1WX9S@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_1076598_15	768671.ThimaDRAFT_2156	3.954e-77	261.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,1RN75@1236|Gammaproteobacteria,1WY5S@135613|Chromatiales	135613|Chromatiales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD1_k127_1076598_13	395493.BegalDRAFT_3263	1.302e-101	336.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,1RMVX@1236|Gammaproteobacteria,460AI@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_1076598_18	1384056.N787_10185	3.03e-49	189.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,1RQ6M@1236|Gammaproteobacteria,1X5GA@135614|Xanthomonadales	135614|Xanthomonadales	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_1076598_2	1049564.TevJSym_ba00130	4.587e-157	505.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,1RNNW@1236|Gammaproteobacteria,1J54A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006721,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016114,GO:0016491,GO:0016614,GO:0016616,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0030145,GO:0030604,GO:0032787,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0046490,GO:0046872,GO:0046914,GO:0048037,GO:0050661,GO:0050662,GO:0051483,GO:0051484,GO:0055114,GO:0070402,GO:0071704,GO:0090407,GO:0097159,GO:1901135,GO:1901265,GO:1901363,GO:1901576	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1814,iECOK1_1307.ECOK1_0174,iECS88_1305.ECS88_0183,iUMN146_1321.UM146_23670,iUTI89_1310.UTI89_C0188	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD1_k127_1076598_5	1049564.TevJSym_ba00120	2.655e-130	430.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,1RMIX@1236|Gammaproteobacteria,1J565@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	zinc metalloprotease	rseP	GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006355,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0016021,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031224,GO:0031226,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0043170,GO:0043856,GO:0044238,GO:0044425,GO:0044459,GO:0044464,GO:0045152,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:0140110,GO:1901564,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD1_k127_1076598_1	519989.ECTPHS_08493	7.451e-254	805.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,1RMAP@1236|Gammaproteobacteria,1WXD9@135613|Chromatiales	135613|Chromatiales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_1076598_20	1283300.ATXB01000001_gene1314	2.986e-36	143.0	COG2825@1|root,COG2825@2|Bacteria,1RD8X@1224|Proteobacteria,1RQIE@1236|Gammaproteobacteria,1XF7V@135618|Methylococcales	135618|Methylococcales	M	Belongs to the skp family	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD1_k127_1076598_12	1384054.N790_06620	1.815e-108	361.0	COG1044@1|root,COG1044@2|Bacteria,1MUX6@1224|Proteobacteria,1RNYI@1236|Gammaproteobacteria,1X2Y9@135614|Xanthomonadales	135614|Xanthomonadales	I	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2,LpxD
HKD1_k127_1076598_17	1122134.KB893650_gene1037	1.203e-55	198.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,1S63E@1236|Gammaproteobacteria,1XJ86@135619|Oceanospirillales	135619|Oceanospirillales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_1076598_14	765910.MARPU_04970	1.784e-101	336.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,1WX0R@135613|Chromatiales	135613|Chromatiales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_1076598_7	1396858.Q666_02755	4.844e-120	398.0	COG0763@1|root,COG0763@2|Bacteria,1MVBI@1224|Proteobacteria,1RNS1@1236|Gammaproteobacteria,465R6@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008194,GO:0008289,GO:0008610,GO:0008654,GO:0008915,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0019637,GO:0019897,GO:0019898,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	iE2348C_1286.E2348C_0187,iEcolC_1368.EcolC_3478	LpxB
HKD1_k127_1076598_10	243231.GSU2263	3.27e-111	367.0	COG0673@1|root,COG0673@2|Bacteria,1MV7C@1224|Proteobacteria,42NV0@68525|delta/epsilon subdivisions,2WK1Y@28221|Deltaproteobacteria,43T3I@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	gnnA	-	-	ko:K09949	-	-	-	-	ko00000	-	-	iAF987.Gmet_2352	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_1076598_19	323261.Noc_2599	6.932e-44	166.0	COG1495@1|root,COG1495@2|Bacteria,1RIJE@1224|Proteobacteria,1S6WD@1236|Gammaproteobacteria,1WZSH@135613|Chromatiales	135613|Chromatiales	C	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein	dsbB	-	-	ko:K03611	-	-	-	-	ko00000,ko03110	5.A.2.1	-	-	DsbB
HKD1_k127_1076598_6	1121405.dsmv_1313	4.399e-122	402.0	COG0616@1|root,COG0616@2|Bacteria	2|Bacteria	OU	serine-type peptidase activity	sppA	-	-	ko:K04773,ko:K21511	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49,SDH_sah
HKD1_k127_1076598_16	187272.Mlg_1201	2.176e-59	207.0	COG0139@1|root,COG0139@2|Bacteria,1MW67@1224|Proteobacteria,1RMV4@1236|Gammaproteobacteria,1WYNT@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH,PRA-PH
HKD1_k127_1087002_4	472759.Nhal_0234	2.636e-27	124.0	COG0745@1|root,COG0745@2|Bacteria,1QW3Q@1224|Proteobacteria,1T2RQ@1236|Gammaproteobacteria,1X2NX@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_1087002_2	404589.Anae109_2395	1.744e-120	398.0	COG1752@1|root,COG1752@2|Bacteria,1Q4S1@1224|Proteobacteria,42S86@68525|delta/epsilon subdivisions,2WNJA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_1087002_0	856793.MICA_1161	1.642e-179	567.0	COG0191@1|root,COG0191@2|Bacteria,1MURX@1224|Proteobacteria,2TSAD@28211|Alphaproteobacteria,4BR5B@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_1087002_1	649747.HMPREF0083_06146	2.397e-162	520.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,4H9ZJ@91061|Bacilli,2721C@186822|Paenibacillaceae	91061|Bacilli	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD1_k127_1087002_3	261292.Nit79A3_3039	1.256e-35	138.0	COG2197@1|root,COG2197@2|Bacteria,1P4TD@1224|Proteobacteria,2VMX4@28216|Betaproteobacteria	28216|Betaproteobacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_1103301_18	1265313.HRUBRA_02574	4.094e-20	94.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,1J4DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Bifunctional purine biosynthesis protein PurH	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
HKD1_k127_1103301_20	395493.BegalDRAFT_1132	7.597e-18	86.0	2BQ8D@1|root,32J37@2|Bacteria,1PCFP@1224|Proteobacteria,1SXG7@1236|Gammaproteobacteria,463B8@72273|Thiotrichales	72273|Thiotrichales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1103301_2	870187.Thini_3341	8.149e-299	927.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,1RMM1@1236|Gammaproteobacteria,4604K@72273|Thiotrichales	72273|Thiotrichales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD1_k127_1103301_8	1134912.AJTV01000014_gene238	1.12e-106	366.0	COG1752@1|root,COG1752@2|Bacteria,1MUI6@1224|Proteobacteria,2U3P9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_1103301_1	472759.Nhal_0455	6.201e-303	941.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMAH@1236|Gammaproteobacteria,1WW1J@135613|Chromatiales	135613|Chromatiales	E	PFAM peptidase M3A and M3B, thimet oligopeptidase F	-	-	3.4.24.70	ko:K01414	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HKD1_k127_1103301_10	1479235.KK366039_gene1529	2.674e-98	327.0	COG3000@1|root,COG3000@2|Bacteria,1MW5G@1224|Proteobacteria,1RQJQ@1236|Gammaproteobacteria,1XJP1@135619|Oceanospirillales	135619|Oceanospirillales	I	Fatty acid hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_1103301_19	160492.XF_2527	4.41e-20	94.0	2DP0J@1|root,3301P@2|Bacteria,1N82J@1224|Proteobacteria,1SH0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ORF located using Glimmer RBSfinder	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1103301_5	765912.Thimo_0133	5.56e-159	507.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,1RP6Q@1236|Gammaproteobacteria,1WW00@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD1_k127_1103301_9	870187.Thini_4460	1.884e-103	344.0	COG0169@1|root,COG0169@2|Bacteria,1MVH4@1224|Proteobacteria,1RPB7@1236|Gammaproteobacteria,460E1@72273|Thiotrichales	72273|Thiotrichales	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_1103301_3	76114.ebA1206	4.18e-271	843.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VJJ2@28216|Betaproteobacteria,2KUZM@206389|Rhodocyclales	206389|Rhodocyclales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_1103301_11	1366050.N234_00605	5.04e-80	276.0	COG0614@1|root,COG0614@2|Bacteria,1N53X@1224|Proteobacteria,2VN8J@28216|Betaproteobacteria,1K4QJ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Pfam Periplasmic binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Peripla_BP_2
HKD1_k127_1103301_12	187272.Mlg_1355	2.687e-74	255.0	COG0494@1|root,COG0494@2|Bacteria,1RDMW@1224|Proteobacteria,1RPZV@1236|Gammaproteobacteria,1WYQS@135613|Chromatiales	135613|Chromatiales	L	PFAM NUDIX hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_1103301_16	1163408.UU9_07176	1.463e-32	132.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,1SDD5@1236|Gammaproteobacteria,1X6IQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD1_k127_1103301_14	402881.Plav_3121	4.106e-43	161.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,1JNNB@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	MazG nucleotide pyrophosphohydrolase domain	mazG	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006213,GO:0006220,GO:0006244,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007154,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009147,GO:0009149,GO:0009151,GO:0009155,GO:0009164,GO:0009166,GO:0009199,GO:0009200,GO:0009203,GO:0009204,GO:0009208,GO:0009210,GO:0009211,GO:0009213,GO:0009215,GO:0009217,GO:0009218,GO:0009219,GO:0009222,GO:0009223,GO:0009259,GO:0009261,GO:0009262,GO:0009264,GO:0009267,GO:0009394,GO:0009605,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0019693,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0034656,GO:0042454,GO:0042594,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044282,GO:0044283,GO:0046046,GO:0046047,GO:0046051,GO:0046052,GO:0046060,GO:0046061,GO:0046070,GO:0046075,GO:0046076,GO:0046080,GO:0046081,GO:0046131,GO:0046133,GO:0046135,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0050896,GO:0051716,GO:0055086,GO:0071496,GO:0071704,GO:0072521,GO:0072523,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576,GO:1901657,GO:1901658	3.6.1.9	ko:K02499,ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG
HKD1_k127_1103301_0	713586.KB900536_gene112	0.0	1159.0	COG1032@1|root,COG1032@2|Bacteria,1MUG3@1224|Proteobacteria,1RN9V@1236|Gammaproteobacteria,1WWU3@135613|Chromatiales	135613|Chromatiales	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD1_k127_1103301_17	643473.KB235930_gene875	5.975e-27	116.0	2E4G4@1|root,32ZB9@2|Bacteria,1G9UK@1117|Cyanobacteria,1HNWN@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1103301_6	63737.Npun_F5602	1.284e-153	492.0	COG3227@1|root,COG3227@2|Bacteria,1G3KW@1117|Cyanobacteria,1HMHN@1161|Nostocales	1117|Cyanobacteria	E	PFAM Thermolysin metallopeptidase, alpha-helical domain	-	-	-	-	-	-	-	-	-	-	-	-	FTP,Peptidase_M4,Peptidase_M4_C
HKD1_k127_1103301_7	396588.Tgr7_1464	5.003e-115	381.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,1RPWB@1236|Gammaproteobacteria,1WWK8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the GcvT family	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD1_k127_1103301_21	1121033.AUCF01000003_gene3058	1.376e-11	66.0	COG5508@1|root,COG5508@2|Bacteria,1Q2RE@1224|Proteobacteria,2V9Z4@28211|Alphaproteobacteria,2JUM0@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF1674)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1674
HKD1_k127_1103301_13	570952.ATVH01000013_gene2905	3.74e-45	166.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2JTDG@204441|Rhodospirillales	204441|Rhodospirillales	C	COG2009 Succinate dehydrogenase fumarate reductase, cytochrome b subunit	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_1103301_15	331869.BAL199_10562	1.893e-39	150.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2U94P@28211|Alphaproteobacteria,4BR1M@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	succinate dehydrogenase	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_1103301_4	395493.BegalDRAFT_2245	1.532e-235	730.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,46047@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_1173545_3	1408422.JHYF01000008_gene3761	5.24e-43	168.0	COG0352@1|root,COG0352@2|Bacteria,1V3ZR@1239|Firmicutes,24DG3@186801|Clostridia,36I8K@31979|Clostridiaceae	186801|Clostridia	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_1173545_2	192952.MM_3234	2.234e-79	273.0	COG2145@1|root,arCOG00019@2157|Archaea,2XSX5@28890|Euryarchaeota,2N9JX@224756|Methanomicrobia	224756|Methanomicrobia	H	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)	thiM	-	2.7.1.50	ko:K00878	ko00730,ko01100,map00730,map01100	M00127	R04448	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iAF692.Mbar_A3319	HK
HKD1_k127_1173545_1	1123253.AUBD01000011_gene2061	0.0	1020.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,1RP1F@1236|Gammaproteobacteria,1X4N0@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD1_k127_1173545_0	1122201.AUAZ01000002_gene1039	0.0	1741.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,1RMYD@1236|Gammaproteobacteria,4643G@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Methionine synthase	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006464,GO:0006479,GO:0006520,GO:0006555,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008213,GO:0008270,GO:0008276,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019538,GO:0019752,GO:0019842,GO:0031419,GO:0032259,GO:0034641,GO:0035999,GO:0036094,GO:0036211,GO:0042084,GO:0042558,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0043436,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046872,GO:0046906,GO:0046914,GO:0048037,GO:0050667,GO:0051186,GO:0071704,GO:0097159,GO:0140096,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_4764,iECUMN_1333.ECUMN_4545	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD1_k127_1197511_13	32057.KB217478_gene6276	5.323e-08	65.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HKD1_k127_1197511_11	1123399.AQVE01000008_gene1538	5.47e-26	114.0	COG1413@1|root,COG1672@1|root,COG1413@2|Bacteria,COG1672@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K06921	-	-	-	-	ko00000	-	-	-	AAA_16,DUF234,HEAT_2,NB-ARC,Trans_reg_C,cNMP_binding
HKD1_k127_1197511_5	56107.Cylst_3996	2.476e-57	208.0	COG1672@1|root,COG1672@2|Bacteria,1G17Z@1117|Cyanobacteria,1HR7D@1161|Nostocales	1117|Cyanobacteria	D	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,GUN4,TIR_2
HKD1_k127_1197511_10	1173026.Glo7428_3849	5.668e-27	110.0	COG1724@1|root,COG1724@2|Bacteria,1G9Z7@1117|Cyanobacteria	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_1197511_8	105559.Nwat_1544	1.677e-27	111.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1197511_12	1049564.TevJSym_ac01570	1.104e-24	109.0	COG3160@1|root,COG3160@2|Bacteria	2|Bacteria	K	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase	rsd	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0010556,GO:0016989,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	ko:K07740	-	-	-	-	ko00000	-	-	-	Rsd_AlgQ
HKD1_k127_1197511_4	519989.ECTPHS_03567	6.072e-63	223.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,1RPYX@1236|Gammaproteobacteria,1WX9X@135613|Chromatiales	135613|Chromatiales	O	PFAM Peptidase M22, glycoprotease	-	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_1197511_6	472759.Nhal_2549	8.944e-56	201.0	COG0071@1|root,COG0071@2|Bacteria,1RH6E@1224|Proteobacteria,1S6FC@1236|Gammaproteobacteria,1WYSM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_1197511_9	1167006.UWK_01675	2.168e-27	114.0	COG0789@1|root,COG0789@2|Bacteria,1N9MT@1224|Proteobacteria	1224|Proteobacteria	K	MerR HTH family regulatory protein	cbpM	-	-	ko:K18997	-	-	-	-	ko00000,ko03036	-	-	-	MerR_2
HKD1_k127_1197511_3	1049564.TevJSym_af00130	1.698e-126	411.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1J5VE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	DnaJ-class molecular chaperone	cbpA	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0097159,GO:1901363	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_1197511_7	396588.Tgr7_2957	2.336e-51	185.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S607@1236|Gammaproteobacteria,1WYTK@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_1197511_2	926560.KE387023_gene3231	1.405e-145	471.0	COG3372@1|root,COG3372@2|Bacteria,1WM7V@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Protein of unknown function (DUF790)	-	-	-	-	-	-	-	-	-	-	-	-	DUF790
HKD1_k127_1197511_1	926560.KE387023_gene3230	8.216e-181	579.0	COG1061@1|root,COG1061@2|Bacteria,1WKX2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	Type III restriction enzyme, res subunit	-	-	-	-	-	-	-	-	-	-	-	-	ERCC3_RAD25_C,Helicase_C,ResIII
HKD1_k127_1197511_0	765912.Thimo_0713	2.423e-181	582.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,1WW3V@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	-	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
HKD1_k127_1200195_4	163908.KB235896_gene668	1.897e-05	49.0	COG2442@1|root,COG2442@2|Bacteria,1G6VW@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_1200195_0	1123368.AUIS01000007_gene2749	0.0	1734.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1MYN4@1224|Proteobacteria,1RMRN@1236|Gammaproteobacteria,2NBUJ@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS_C,GATase_5
HKD1_k127_1200195_2	765913.ThidrDRAFT_2502	5.863e-139	450.0	COG2041@1|root,COG2041@2|Bacteria,1MUW0@1224|Proteobacteria,1RQ2J@1236|Gammaproteobacteria,1WXW8@135613|Chromatiales	135613|Chromatiales	C	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HKD1_k127_1200195_3	1255043.TVNIR_1026	3.85e-11	71.0	2CGZG@1|root,335XU@2|Bacteria,1NF4Y@1224|Proteobacteria,1SFVI@1236|Gammaproteobacteria,1WZ9E@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1200195_1	251221.35213669	2.652e-142	460.0	COG4948@1|root,COG4948@2|Bacteria,1FZYA@1117|Cyanobacteria	1117|Cyanobacteria	M	Mandelate racemase muconate lactonizing enzyme	-	-	4.2.1.113,5.1.1.20	ko:K02549,ko:K19802	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031,R10938	RC01053,RC03309	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_1204766_6	765910.MARPU_16585	2.703e-74	254.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,1RPQ7@1236|Gammaproteobacteria,1WXMZ@135613|Chromatiales	135613|Chromatiales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD1_k127_1204766_12	1265313.HRUBRA_02544	7.684e-14	73.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1J7FM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GM	NAD(P)H-binding	ybjT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	DUF2867,Epimerase,NAD_binding_10
HKD1_k127_1204766_2	765911.Thivi_2724	2.85e-179	571.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,1RMSF@1236|Gammaproteobacteria,1WVW6@135613|Chromatiales	135613|Chromatiales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD1_k127_1204766_10	1095769.CAHF01000013_gene3160	2.156e-24	107.0	COG2878@1|root,COG2878@2|Bacteria,1MUWU@1224|Proteobacteria,2VN5I@28216|Betaproteobacteria,472FP@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Part of a membrane complex involved in electron transport	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4_21
HKD1_k127_1204766_3	572477.Alvin_1722	7.881e-158	510.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_1204766_8	391615.ABSJ01000059_gene2172	2.003e-39	152.0	2ED3C@1|root,33708@2|Bacteria,1NETB@1224|Proteobacteria,1SDJK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2505)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2505
HKD1_k127_1204766_9	187272.Mlg_1161	7.39e-30	120.0	2EB0P@1|root,3351I@2|Bacteria,1NAEB@1224|Proteobacteria,1SCR3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1204766_11	1276756.AUEX01000012_gene3553	1.616e-15	78.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,2VHRJ@28216|Betaproteobacteria,4AC0Z@80864|Comamonadaceae	28216|Betaproteobacteria	H	AMP-binding enzyme	paaK_2	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_1204766_7	1340493.JNIF01000003_gene4091	5.125e-53	196.0	COG3719@1|root,COG3719@2|Bacteria	2|Bacteria	J	Belongs to the RNase T2 family	rns	-	3.1.27.1	ko:K01166	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_T2
HKD1_k127_1204766_1	497321.C664_07768	9.171e-189	600.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2VHN5@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the pyruvate kinase family	pykA2	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_1204766_5	1121935.AQXX01000087_gene4628	6.212e-99	331.0	COG0697@1|root,COG0697@2|Bacteria,1MVKG@1224|Proteobacteria,1S2WV@1236|Gammaproteobacteria,1XPNS@135619|Oceanospirillales	135619|Oceanospirillales	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	ko:K15268	-	-	-	-	ko00000,ko02000	2.A.7.3.2	-	-	EamA
HKD1_k127_1204766_14	1449350.OCH239_21885	1.529e-05	58.0	COG3577@1|root,COG3577@2|Bacteria,1N2PE@1224|Proteobacteria,2VG8P@28211|Alphaproteobacteria,4KKQX@93682|Roseivivax	28211|Alphaproteobacteria	S	aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HKD1_k127_1204766_15	91464.S7335_2630	3.513e-05	57.0	COG0457@1|root,COG0457@2|Bacteria,1G07G@1117|Cyanobacteria,1H0Y6@1129|Synechococcus	1117|Cyanobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_4,TPR_6,TPR_8
HKD1_k127_1204766_4	697282.Mettu_0390	3.722e-114	375.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,1S0QR@1236|Gammaproteobacteria,1XFU4@135618|Methylococcales	135618|Methylococcales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_1204766_13	1163408.UU9_14355	4.084e-07	53.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,1X47X@135614|Xanthomonadales	135614|Xanthomonadales	L	EcoEI R protein C-terminal	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N_2,Helicase_C,ResIII
HKD1_k127_1204766_0	187272.Mlg_1485	0.0	1098.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,1RNW3@1236|Gammaproteobacteria,1WVV0@135613|Chromatiales	135613|Chromatiales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD1_k127_1209078_4	693661.Arcve_0835	4.831e-71	253.0	COG3335@1|root,COG3415@1|root,arCOG02128@2157|Archaea,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_32,HTH_33
HKD1_k127_1209078_5	765914.ThisiDRAFT_1623	2.88e-65	225.0	COG4451@1|root,COG4451@2|Bacteria,1R9ZE@1224|Proteobacteria,1S3XZ@1236|Gammaproteobacteria,1X23Q@135613|Chromatiales	135613|Chromatiales	C	PFAM Ribulose bisphosphate carboxylase, small chain	-	-	4.1.1.39	ko:K01602	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_small
HKD1_k127_1209078_0	472759.Nhal_3435	8.131e-297	912.0	COG1850@1|root,COG1850@2|Bacteria,1MWEB@1224|Proteobacteria,1RRMX@1236|Gammaproteobacteria,1WXC1@135613|Chromatiales	135613|Chromatiales	G	RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site	cbbL	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
HKD1_k127_1209078_3	519989.ECTPHS_02991	1.197e-132	468.0	COG3164@1|root,COG3164@2|Bacteria,1MXWF@1224|Proteobacteria,1RNUK@1236|Gammaproteobacteria,1WXQJ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function	-	-	-	-	-	-	-	-	-	-	-	-	AsmA_2,DUF3971
HKD1_k127_1209078_2	349521.HCH_05330	8.692e-191	608.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,1RMIW@1236|Gammaproteobacteria,1XI2S@135619|Oceanospirillales	135619|Oceanospirillales	J	Involved in the processing of the 5'end of 16S rRNA	-	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD1_k127_1209078_6	1304275.C41B8_11413	1.493e-34	141.0	COG0560@1|root,COG0560@2|Bacteria,1MXGP@1224|Proteobacteria,1RQNV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Hydrolase	cicA	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_1209078_7	765911.Thivi_3892	7.515e-20	91.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales	135613|Chromatiales	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
HKD1_k127_1209078_1	706587.Desti_3255	5.344e-273	848.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42PXA@68525|delta/epsilon subdivisions,2WM6E@28221|Deltaproteobacteria	28221|Deltaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_1212584_0	1132855.KB913035_gene1495	2.857e-110	360.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KMG8@206350|Nitrosomonadales	28216|Betaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	cusA	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD1_k127_1212584_4	314345.SPV1_10666	1.785e-17	85.0	28UDP@1|root,2ZGIS@2|Bacteria,1QYVB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1212584_2	314345.SPV1_10636	6.966e-32	128.0	2E5JD@1|root,330AQ@2|Bacteria,1N86Q@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1212584_3	765911.Thivi_1773	9.906e-20	93.0	2BU1D@1|root,32PA2@2|Bacteria,1N4TV@1224|Proteobacteria,1SBJ8@1236|Gammaproteobacteria,1WZ1H@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1212584_1	580332.Slit_2557	5.705e-42	161.0	COG1527@1|root,COG1527@2|Bacteria,1R7PV@1224|Proteobacteria,2W2GY@28216|Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase (C/AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD1_k127_1246561_5	1278309.KB907099_gene2837	5.155e-68	234.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1XHDY@135619|Oceanospirillales	135619|Oceanospirillales	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_1246561_1	1380394.JADL01000004_gene5856	2.8e-322	1002.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JPC0@204441|Rhodospirillales	204441|Rhodospirillales	C	malic enzyme	dme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD1_k127_1246561_2	1382359.JIAL01000001_gene774	2.46e-271	840.0	COG1838@1|root,COG1951@1|root,COG1838@2|Bacteria,COG1951@2|Bacteria,3Y2FA@57723|Acidobacteria,2JI4J@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible hydration of fumarate to (S)- malate	-	-	4.2.1.2	ko:K01676	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase,Fumerase_C
HKD1_k127_1246561_4	1223521.BBJX01000005_gene1933	2.813e-97	327.0	COG1024@1|root,COG1024@2|Bacteria,1PJ4R@1224|Proteobacteria,2WEJG@28216|Betaproteobacteria,4AJ3P@80864|Comamonadaceae	28216|Betaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_1246561_0	1458427.BAWN01000020_gene1218	0.0	1026.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,4A9Z9@80864|Comamonadaceae	28216|Betaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_1246561_6	1038860.AXAP01000098_gene5343	3.933e-48	175.0	COG1504@1|root,COG1504@2|Bacteria,1RGJ6@1224|Proteobacteria,2U79N@28211|Alphaproteobacteria,3JYZV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HKD1_k127_1246561_3	631362.Thi970DRAFT_01089	3.398e-138	445.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria,1WX7U@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_1251305_8	1192034.CAP_3828	5.333e-24	111.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	-	2.3.1.189	ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3
HKD1_k127_1251305_2	697282.Mettu_0625	4.815e-131	424.0	COG1305@1|root,COG1305@2|Bacteria,1MVAG@1224|Proteobacteria,1RMXM@1236|Gammaproteobacteria,1XEW2@135618|Methylococcales	135618|Methylococcales	E	Bacterial transglutaminase-like N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_1251305_1	1210884.HG799463_gene9619	6.973e-160	532.0	COG3829@1|root,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_1251305_3	472759.Nhal_3011	4.325e-86	300.0	COG0515@1|root,COG1262@1|root,COG3409@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG3409@2|Bacteria,1NQ5K@1224|Proteobacteria,1S2PN@1236|Gammaproteobacteria,1WYNY@135613|Chromatiales	135613|Chromatiales	KLT	PFAM Sulphatase-modifying factor	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,PG_binding_1,Pkinase
HKD1_k127_1251305_7	765912.Thimo_0607	2.009e-27	126.0	COG0515@1|root,COG1413@1|root,COG0515@2|Bacteria,COG1413@2|Bacteria,1N79H@1224|Proteobacteria,1SD3H@1236|Gammaproteobacteria,1X2BS@135613|Chromatiales	135613|Chromatiales	KLT	Protein of unknown function (DUF1566)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1566
HKD1_k127_1251305_6	1150626.PHAMO_20098	4.831e-31	128.0	COG0607@1|root,COG0607@2|Bacteria,1RJQ6@1224|Proteobacteria,2VFUG@28211|Alphaproteobacteria,2JUIN@204441|Rhodospirillales	204441|Rhodospirillales	M	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_1251305_5	929556.Solca_2746	2.507e-59	210.0	COG2001@1|root,COG2001@2|Bacteria,4NM4X@976|Bacteroidetes,1IS84@117747|Sphingobacteriia	976|Bacteroidetes	K	Belongs to the MraZ family	mraZ	GO:0000976,GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031333,GO:0043254,GO:0043565,GO:0044087,GO:0044212,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902679,GO:1903506,GO:1903507,GO:1990837,GO:2000112,GO:2000113,GO:2000142,GO:2000143,GO:2001141	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_1251305_4	1123368.AUIS01000019_gene1213	1.455e-67	233.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,1S40Y@1236|Gammaproteobacteria,2NCY9@225057|Acidithiobacillales	225057|Acidithiobacillales	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_1251305_0	631362.Thi970DRAFT_03359	7.757e-243	766.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,1RNCM@1236|Gammaproteobacteria,1WWYI@135613|Chromatiales	135613|Chromatiales	C	Aldehyde	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HKD1_k127_1257981_0	396588.Tgr7_0882	3.868e-120	391.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,1RMBG@1236|Gammaproteobacteria,1WWHC@135613|Chromatiales	135613|Chromatiales	J	Adds poly(A) tail to the 3' end of many RNAs, which usually targets these RNAs for decay. Plays a significant role in the global control of gene expression, through influencing the rate of transcript degradation, and in the general RNA quality control	pcnB	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd,PolyA_pol_arg_C
HKD1_k127_1257981_2	1207076.ALAT01000011_gene1562	3.593e-46	172.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,1S6BS@1236|Gammaproteobacteria,1Z22S@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD1_k127_1257981_1	472759.Nhal_3898	1.347e-98	330.0	COG4535@1|root,COG4535@2|Bacteria,1QTU8@1224|Proteobacteria,1RMKX@1236|Gammaproteobacteria,1WW4G@135613|Chromatiales	135613|Chromatiales	P	PFAM CBS domain	-	-	-	ko:K06189	-	-	-	-	ko00000,ko02000	9.A.40.1.2	-	-	CBS,CorC_HlyC
HKD1_k127_1257981_3	395493.BegalDRAFT_1841	2.642e-10	66.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,45ZMQ@72273|Thiotrichales	72273|Thiotrichales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD1_k127_1273104_3	395493.BegalDRAFT_2785	2.277e-153	527.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,1RMMF@1236|Gammaproteobacteria,46124@72273|Thiotrichales	72273|Thiotrichales	S	TamB, inner membrane protein subunit of TAM complex	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD1_k127_1273104_5	395493.BegalDRAFT_0660	2.174e-146	486.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,460T9@72273|Thiotrichales	72273|Thiotrichales	M	PFAM Surface antigen	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HKD1_k127_1273104_0	2340.JV46_04040	3.325e-210	662.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,1RMU9@1236|Gammaproteobacteria,1J4KT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006605,GO:0006612,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0015031,GO:0015833,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0032991,GO:0033036,GO:0034613,GO:0035639,GO:0036094,GO:0042886,GO:0043167,GO:0043168,GO:0044424,GO:0044444,GO:0044464,GO:0045184,GO:0046907,GO:0048500,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705,GO:0072657,GO:0090150,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1990904	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_1273104_1	227377.CBU_2092	9.169e-208	661.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,1RPM0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	GO:0003674,GO:0003824,GO:0004611,GO:0004612,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006094,GO:0008150,GO:0008152,GO:0009058,GO:0016051,GO:0016829,GO:0016830,GO:0016831,GO:0019318,GO:0019319,GO:0044238,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046364,GO:0071704,GO:1901576	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD1_k127_1273104_10	1307761.L21SP2_2105	2.81e-49	183.0	COG3605@1|root,COG3605@2|Bacteria,2JBCF@203691|Spirochaetes	203691|Spirochaetes	T	GAF domain	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_1273104_12	716544.wcw_1425	1.192e-07	57.0	COG1080@1|root,COG1080@2|Bacteria,2JFGB@204428|Chlamydiae	204428|Chlamydiae	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsI	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_1273104_8	765912.Thimo_0512	3.603e-81	278.0	COG4137@1|root,COG4137@2|Bacteria,1R3YD@1224|Proteobacteria,1RPUQ@1236|Gammaproteobacteria,1WX1P@135613|Chromatiales	135613|Chromatiales	S	Cytochrome c assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_asm
HKD1_k127_1273104_4	349124.Hhal_0469	3.704e-153	494.0	COG4536@1|root,COG4536@2|Bacteria,1NZ99@1224|Proteobacteria,1RNCE@1236|Gammaproteobacteria,1WWQM@135613|Chromatiales	135613|Chromatiales	P	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_1273104_6	935863.AWZR01000003_gene2774	1.444e-135	447.0	COG1653@1|root,COG1653@2|Bacteria,1MX59@1224|Proteobacteria,1RZSI@1236|Gammaproteobacteria,1X356@135614|Xanthomonadales	135614|Xanthomonadales	G	ABC transporter substrate-binding protein	malE	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1,SBP_bac_8
HKD1_k127_1273104_7	1439940.BAY1663_00916	2.337e-126	414.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,1RMNP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	GO:0003674,GO:0003824,GO:0003887,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0022616,GO:0032991,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0042575,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0061695,GO:0071704,GO:0071897,GO:0090304,GO:0140097,GO:1901360,GO:1901362,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD1_k127_1273104_9	713586.KB900536_gene2142	6.836e-76	267.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,1RN5P@1236|Gammaproteobacteria,1WYPF@135613|Chromatiales	135613|Chromatiales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	AAA_23,SMC_N
HKD1_k127_1273104_2	745411.B3C1_06017	2.287e-179	570.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1J4W4@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003916,GO:0003918,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006265,GO:0006351,GO:0006725,GO:0006807,GO:0006996,GO:0007059,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009295,GO:0009330,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016853,GO:0016887,GO:0017076,GO:0017111,GO:0018130,GO:0019438,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0032774,GO:0032991,GO:0034335,GO:0034641,GO:0034645,GO:0034654,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051276,GO:0061505,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:0097367,GO:0097659,GO:0140097,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901576	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_1273104_11	1096546.WYO_1684	4.579e-23	105.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,1JUYV@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_1278305_3	1049564.TevJSym_bj00030	6.739e-63	222.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,1RMUR@1236|Gammaproteobacteria,1J4TI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	Involved in lipid A export and possibly also in glycerophospholipid export and for biogenesis of the outer membrane. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation	msbA	GO:0000166,GO:0003674,GO:0003824,GO:0005215,GO:0005319,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006855,GO:0006869,GO:0008144,GO:0008150,GO:0008289,GO:0008559,GO:0009987,GO:0010876,GO:0015221,GO:0015238,GO:0015399,GO:0015405,GO:0015437,GO:0015893,GO:0015920,GO:0016020,GO:0016021,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0022804,GO:0022857,GO:0022884,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033036,GO:0034040,GO:0034204,GO:0035639,GO:0036094,GO:0042221,GO:0042493,GO:0042623,GO:0042626,GO:0042802,GO:0042908,GO:0042910,GO:0043167,GO:0043168,GO:0043190,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0061024,GO:0065007,GO:0065008,GO:0071702,GO:0071840,GO:0071944,GO:0097035,GO:0097159,GO:0097367,GO:0098533,GO:0098796,GO:0098797,GO:1901264,GO:1901265,GO:1901363,GO:1901505,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	iJN746.PP_4935,iPC815.YPO1395,iUMN146_1321.UM146_12980	ABC_membrane,ABC_tran
HKD1_k127_1278305_1	1049564.TevJSym_bj00010	1.921e-79	279.0	COG0665@1|root,COG0665@2|Bacteria,1Q8AY@1224|Proteobacteria,1RSC9@1236|Gammaproteobacteria,1JC30@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD1_k127_1278305_0	105559.Nwat_0503	4.694e-143	466.0	COG1519@1|root,COG1519@2|Bacteria,1MU9F@1224|Proteobacteria,1RNBR@1236|Gammaproteobacteria,1WX73@135613|Chromatiales	135613|Chromatiales	M	PFAM Three-deoxy-D-manno-octulosonic-acid transferase	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_1,Glycos_transf_N,Kdo
HKD1_k127_1278305_4	395493.BegalDRAFT_1818	2.421e-59	214.0	COG1011@1|root,COG1011@2|Bacteria,1N0I6@1224|Proteobacteria,1RQ41@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Hydrolase	yigB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0006766,GO:0006767,GO:0006771,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0017144,GO:0018130,GO:0022611,GO:0032502,GO:0034641,GO:0042364,GO:0042578,GO:0042726,GO:0042727,GO:0043167,GO:0043169,GO:0043726,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.1.3.102,3.1.3.104	ko:K20862	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00548,R07280	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2
HKD1_k127_1278305_6	1415778.JQMM01000001_gene343	2.747e-08	58.0	2EVHE@1|root,33NXT@2|Bacteria,1NKWJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1278305_5	1304275.C41B8_02237	8.445e-16	79.0	2C6IQ@1|root,33JPD@2|Bacteria,1NN0A@1224|Proteobacteria,1SHF7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ORF6N
HKD1_k127_1278305_2	1122139.KB907880_gene2834	2.143e-69	237.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1XIQP@135619|Oceanospirillales	135619|Oceanospirillales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_1278786_1	316067.Geob_0242	6.171e-98	323.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,42QZY@68525|delta/epsilon subdivisions,2WMN5@28221|Deltaproteobacteria,43SVZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_1278786_0	574966.KB898652_gene1844	3.692e-203	648.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,1RMF4@1236|Gammaproteobacteria,1XI04@135619|Oceanospirillales	135619|Oceanospirillales	L	exonuclease recJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_1278786_2	983917.RGE_00270	7.381e-29	120.0	COG2199@1|root,COG2199@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WEJC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	DUF484,GGDEF
HKD1_k127_1303659_5	1163617.SCD_n01097	3.821e-76	261.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria	28216|Betaproteobacteria	M	lipoprotein releasing system, transmembrane protein, LolC E family	lolC	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_1303659_4	396588.Tgr7_0212	2.185e-89	301.0	COG0664@1|root,COG0664@2|Bacteria,1MVGE@1224|Proteobacteria,1RPTB@1236|Gammaproteobacteria,1WWQ7@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K01420	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_1303659_3	472759.Nhal_3505	3.076e-106	360.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1WVXZ@135613|Chromatiales	135613|Chromatiales	MU	type I secretion outer membrane protein, TolC	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_1303659_2	246197.MXAN_4187	2.014e-128	421.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,42N6K@68525|delta/epsilon subdivisions,2WKFH@28221|Deltaproteobacteria,2YUIN@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD1_k127_1303659_15	283942.IL0912	2.837e-08	57.0	2DDVB@1|root,2ZJEV@2|Bacteria,1PBKE@1224|Proteobacteria,1SUSK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Putative addiction module component	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
HKD1_k127_1303659_0	396588.Tgr7_1276	2.521e-277	872.0	COG0068@1|root,COG0068@2|Bacteria,1MVP8@1224|Proteobacteria,1RP08@1236|Gammaproteobacteria,1WX2T@135613|Chromatiales	135613|Chromatiales	O	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide	-	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD1_k127_1303659_7	1249627.D779_2430	3.835e-42	156.0	COG1449@1|root,COG1449@2|Bacteria,1R18I@1224|Proteobacteria,1SGAD@1236|Gammaproteobacteria,1X04T@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_1303659_12	1249627.D779_2430	3.539e-12	69.0	COG1449@1|root,COG1449@2|Bacteria,1R18I@1224|Proteobacteria,1SGAD@1236|Gammaproteobacteria,1X04T@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_1303659_9	1267535.KB906767_gene4254	1.691e-33	136.0	COG5654@1|root,COG5654@2|Bacteria,3Y5S0@57723|Acidobacteria,2JJWB@204432|Acidobacteriia	204432|Acidobacteriia	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD1_k127_1303659_11	391615.ABSJ01000037_gene838	8.223e-18	86.0	COG4190@1|root,COG4190@2|Bacteria,1N98Y@1224|Proteobacteria,1SD1M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_1303659_14	1283300.ATXB01000001_gene284	3.237e-10	61.0	2E33J@1|root,32Y3P@2|Bacteria,1N9JJ@1224|Proteobacteria,1SCAK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1303659_8	472759.Nhal_0278	4.134e-34	132.0	2EBQI@1|root,335QJ@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HKD1_k127_1303659_10	118168.MC7420_5341	1.808e-22	108.0	COG0265@1|root,COG0265@2|Bacteria,1G3U2@1117|Cyanobacteria,1HCF7@1150|Oscillatoriales	1117|Cyanobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_1303659_13	1183438.GKIL_3608	1.784e-11	75.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	celD	-	-	ko:K20444,ko:K20543	-	-	-	-	ko00000,ko01000,ko01005,ko02000	1.B.55.3,4.D.1.3	GT2,GT4	-	Acetyltransf_6,BCSC_C,Glyco_transf_41,TPR_16
HKD1_k127_1303659_6	395493.BegalDRAFT_0532	2.252e-54	210.0	COG3118@1|root,COG3118@2|Bacteria	2|Bacteria	O	belongs to the thioredoxin family	celD	-	-	ko:K20444,ko:K20543	-	-	-	-	ko00000,ko01000,ko01005,ko02000	1.B.55.3,4.D.1.3	GT2,GT4	-	Acetyltransf_6,BCSC_C,Glyco_transf_41,TPR_16
HKD1_k127_1303659_1	1249627.D779_2430	2.366e-229	717.0	COG1449@1|root,COG1449@2|Bacteria,1R18I@1224|Proteobacteria,1SGAD@1236|Gammaproteobacteria,1X04T@135613|Chromatiales	135613|Chromatiales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_1304991_2	1173263.Syn7502_02730	1.088e-17	88.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
HKD1_k127_1304991_0	243233.MCA1763	1.183e-117	394.0	COG4645@1|root,COG4645@2|Bacteria,1PI9Q@1224|Proteobacteria,1SYB2@1236|Gammaproteobacteria,1XG3R@135618|Methylococcales	135618|Methylococcales	S	OpgC protein	-	-	-	-	-	-	-	-	-	-	-	-	OpgC_C
HKD1_k127_1304991_1	682795.AciX8_4290	2.44e-79	278.0	COG0657@1|root,COG0657@2|Bacteria,3Y6FP@57723|Acidobacteria,2JM6P@204432|Acidobacteriia	204432|Acidobacteriia	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1304991_3	305700.B447_15236	3.235e-11	68.0	COG2928@1|root,COG2928@2|Bacteria,1MWT5@1224|Proteobacteria,2VQY7@28216|Betaproteobacteria,2KYP5@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD1_k127_1305026_0	1454004.AW11_00930	4.585e-107	352.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2WC2P@28216|Betaproteobacteria,1KR2C@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1305026_1	1144275.COCOR_03167	1.488e-61	221.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,42US2@68525|delta/epsilon subdivisions,2WQT6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD1_k127_1305026_2	1144305.PMI02_03109	2.717e-12	76.0	2E8Y7@1|root,3337X@2|Bacteria,1NBJG@1224|Proteobacteria,2UW7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1331144_3	292415.Tbd_0072	1.269e-57	203.0	COG1522@1|root,COG1522@2|Bacteria,1RCY6@1224|Proteobacteria,2VR9X@28216|Betaproteobacteria,1KT8U@119069|Hydrogenophilales	119069|Hydrogenophilales	K	transcriptional regulator AsnC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HKD1_k127_1331144_4	640081.Dsui_1931	3.791e-49	179.0	COG1522@1|root,COG1522@2|Bacteria,1RIKY@1224|Proteobacteria,2VSBM@28216|Betaproteobacteria,2KWF6@206389|Rhodocyclales	206389|Rhodocyclales	K	overlaps another CDS with the same product name	nirG	-	-	-	-	-	-	-	-	-	-	-	HTH_AsnC-type
HKD1_k127_1331144_2	1304883.KI912532_gene3209	1.402e-105	353.0	COG1522@1|root,COG1522@2|Bacteria,1NVYY@1224|Proteobacteria,2VHP8@28216|Betaproteobacteria,2KUR4@206389|Rhodocyclales	206389|Rhodocyclales	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1331144_1	1163617.SCD_n00372	4.607e-175	556.0	COG3391@1|root,COG3391@2|Bacteria,1QD5Q@1224|Proteobacteria,2VH1W@28216|Betaproteobacteria	28216|Betaproteobacteria	S	cytochrome d1, heme region	nirF	-	-	ko:K19345	-	-	-	-	ko00000	-	-	-	Cytochrom_D1
HKD1_k127_1331144_6	1223521.BBJX01000001_gene996	1.654e-34	137.0	COG2010@1|root,COG2010@2|Bacteria,1N73U@1224|Proteobacteria,2VTXS@28216|Betaproteobacteria,4AF3A@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	nirC	-	-	ko:K19344	-	-	-	-	ko00000	-	-	-	Cytochrome_CBB3
HKD1_k127_1331144_5	1112274.KI911560_gene1043	9.968e-35	135.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales	206350|Nitrosomonadales	C	PFAM cytochrome c, class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrome_CBB3
HKD1_k127_1331144_0	264198.Reut_B5010	1.579e-199	623.0	COG2010@1|root,COG2010@2|Bacteria,1N3PN@1224|Proteobacteria,2VHSF@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome d1, heme	nirS	-	1.7.2.1,1.7.99.1	ko:K15864	ko00910,ko01120,map00910,map01120	M00529	R00143,R00783,R00785	RC00086,RC02797	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytochrom_D1,Cytochrome_CBB3
HKD1_k127_1344016_6	926692.AZYG01000064_gene1005	4.162e-36	141.0	COG1543@1|root,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,248UF@186801|Clostridia	186801|Clostridia	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
HKD1_k127_1344016_0	1283300.ATXB01000001_gene1241	2.61e-201	641.0	COG0297@1|root,COG3330@1|root,COG0297@2|Bacteria,COG3330@2|Bacteria,1R6U0@1224|Proteobacteria	1224|Proteobacteria	G	Starch synthase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glyco_transf_5,Glycos_transf_1
HKD1_k127_1344016_1	313624.NSP_4890	6.148e-124	404.0	COG4360@1|root,COG4360@2|Bacteria,1G2S9@1117|Cyanobacteria,1HIMD@1161|Nostocales	1117|Cyanobacteria	F	PFAM ATP adenylyltransferase	apa2	-	2.7.7.53	ko:K00988	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	ATP_transf
HKD1_k127_1344016_11	1348657.M622_11630	9.59e-12	67.0	COG3668@1|root,COG3668@2|Bacteria,1N2I9@1224|Proteobacteria,2VV9N@28216|Betaproteobacteria	28216|Betaproteobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_1344016_9	1282361.ABAC402_12355	8.302e-27	113.0	COG3609@1|root,COG3609@2|Bacteria	2|Bacteria	K	positive regulation of growth	-	-	-	ko:K07746	-	-	-	-	ko00000,ko02048	-	-	-	ParD_antitoxin
HKD1_k127_1344016_4	545694.TREPR_0418	3.147e-66	241.0	COG1262@1|root,COG1262@2|Bacteria,2J5Y8@203691|Spirochaetes	203691|Spirochaetes	C	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Flavodoxin_4
HKD1_k127_1344016_8	706587.Desti_4240	1.698e-31	128.0	COG1669@1|root,COG1669@2|Bacteria,1N9G2@1224|Proteobacteria,42WM2@68525|delta/epsilon subdivisions,2WSBB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_1344016_7	706587.Desti_4241	1.571e-32	132.0	COG2361@1|root,COG2361@2|Bacteria,1NA32@1224|Proteobacteria,43B8M@68525|delta/epsilon subdivisions,2X6MY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HKD1_k127_1344016_5	449447.MAE_42710	1.535e-43	184.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1GBYD@1117|Cyanobacteria	1117|Cyanobacteria	KLT	Sulfatase-modifying factor enzyme 1	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FGE-sulfatase
HKD1_k127_1344016_3	502025.Hoch_2068	4.671e-78	296.0	2AJ80@1|root,319SU@2|Bacteria,1Q3V2@1224|Proteobacteria,439P7@68525|delta/epsilon subdivisions,2X50P@28221|Deltaproteobacteria,2YZY4@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1344016_2	502025.Hoch_2067	9.89e-81	280.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,42MTW@68525|delta/epsilon subdivisions,2WJ0J@28221|Deltaproteobacteria,2YYA5@29|Myxococcales	28221|Deltaproteobacteria	S	AAA domain (Cdc48 subfamily)	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HKD1_k127_1344016_10	448385.sce6216	2.445e-13	80.0	COG0846@1|root,COG0846@2|Bacteria,1Q3X8@1224|Proteobacteria,43440@68525|delta/epsilon subdivisions,2X53C@28221|Deltaproteobacteria,2Z024@29|Myxococcales	28221|Deltaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1348334_3	395964.KE386496_gene103	3.815e-06	50.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,3N9UN@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_1348334_1	876269.ARWA01000001_gene241	9.368e-49	177.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3NB0Q@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	STAS domain	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_1348334_0	123899.JPQP01000023_gene2908	2.324e-256	795.0	COG0076@1|root,COG0076@2|Bacteria,1MX25@1224|Proteobacteria,2W8CY@28216|Betaproteobacteria,3T5KU@506|Alcaligenaceae	28216|Betaproteobacteria	E	Belongs to the group II decarboxylase family	gadA2	GO:0003674,GO:0003824,GO:0004351,GO:0006873,GO:0006885,GO:0008150,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0019725,GO:0030003,GO:0030004,GO:0030641,GO:0042592,GO:0045852,GO:0048878,GO:0050801,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0098771	4.1.1.15	ko:K01580	ko00250,ko00410,ko00430,ko00650,ko01100,ko01110,ko01120,ko02024,ko04727,ko04940,map00250,map00410,map00430,map00650,map01100,map01110,map01120,map02024,map04727,map04940	M00027	R00261,R00489,R01682,R02466	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Pyridoxal_deC
HKD1_k127_1348334_4	1173022.Cri9333_1491	6.046e-05	46.0	2C5EY@1|root,32YQJ@2|Bacteria,1G8TB@1117|Cyanobacteria,1HCFY@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HKD1_k127_1348334_2	1230476.C207_00380	2.806e-40	153.0	COG2072@1|root,COG2072@2|Bacteria,1MU71@1224|Proteobacteria,2TV2E@28211|Alphaproteobacteria,3JQVH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	FMO-like,K_oxygenase,NAD_binding_8,Pyr_redox_2
HKD1_k127_1379316_9	671143.DAMO_2352	7.179e-82	280.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	yeeZ	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
HKD1_k127_1379316_13	243233.MCA1068	3.122e-64	226.0	COG2863@1|root,COG2863@2|Bacteria,1MZU1@1224|Proteobacteria,1SBJR@1236|Gammaproteobacteria,1XGZN@135618|Methylococcales	135618|Methylococcales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_1379316_1	1123368.AUIS01000006_gene587	9.88e-136	440.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,1RMF1@1236|Gammaproteobacteria,2NCHY@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Belongs to the agmatine deiminase family	-	-	-	-	-	-	-	-	-	-	-	-	PAD_porph
HKD1_k127_1379316_12	391615.ABSJ01000055_gene1366	3.424e-77	266.0	COG2207@1|root,COG2207@2|Bacteria,1N70D@1224|Proteobacteria,1S9TN@1236|Gammaproteobacteria,1JBPK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD1_k127_1379316_5	472759.Nhal_3149	6.909e-115	378.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,1RP09@1236|Gammaproteobacteria,1WX0B@135613|Chromatiales	135613|Chromatiales	O	heat shock protein DnaJ	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_1379316_10	329726.AM1_3822	2.561e-81	273.0	COG0521@1|root,COG0521@2|Bacteria,1G514@1117|Cyanobacteria	1117|Cyanobacteria	H	May be involved in the biosynthesis of molybdopterin	moaB	-	2.7.7.75	ko:K03638,ko:K03831	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09726	RC00002	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth
HKD1_k127_1379316_8	1125863.JAFN01000001_gene110	1.58e-88	302.0	COG1752@1|root,COG1752@2|Bacteria,1MUM9@1224|Proteobacteria,42R8Z@68525|delta/epsilon subdivisions,2WMXX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM Patatin	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin,cNMP_binding
HKD1_k127_1379316_24	1128427.KB904821_gene859	1.504e-19	94.0	COG1669@1|root,COG1669@2|Bacteria,1G88F@1117|Cyanobacteria,1HC46@1150|Oscillatoriales	1117|Cyanobacteria	S	Nucleotidyltransferase domain	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_1379316_22	1173024.KI912148_gene4779	1.802e-35	138.0	COG2442@1|root,COG2442@2|Bacteria,1G71J@1117|Cyanobacteria,1JJ35@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_1379316_19	926550.CLDAP_26780	1.391e-40	155.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1379316_23	398767.Glov_1581	1.624e-29	122.0	COG1848@1|root,COG1848@2|Bacteria,1NH4K@1224|Proteobacteria	1224|Proteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_1379316_26	545276.KB898733_gene2549	1.497e-17	85.0	COG2161@1|root,COG2161@2|Bacteria,1N6B6@1224|Proteobacteria	1224|Proteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_1379316_4	1283300.ATXB01000001_gene736	2.754e-117	383.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1RMCJ@1236|Gammaproteobacteria,1XET4@135618|Methylococcales	135618|Methylococcales	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_1379316_6	519989.ECTPHS_01724	1.156e-104	346.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RM9H@1236|Gammaproteobacteria,1WWID@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_1379316_16	472759.Nhal_0343	5.273e-53	191.0	COG1463@1|root,COG1463@2|Bacteria,1NCUG@1224|Proteobacteria,1RQ0Y@1236|Gammaproteobacteria,1WXYG@135613|Chromatiales	135613|Chromatiales	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_1379316_17	323261.Noc_2782	1.615e-46	175.0	COG2854@1|root,COG2854@2|Bacteria,1NKFA@1224|Proteobacteria,1RNJW@1236|Gammaproteobacteria,1WXHN@135613|Chromatiales	135613|Chromatiales	Q	PFAM toluene tolerance	-	-	-	ko:K07323	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	MlaC
HKD1_k127_1379316_27	1283300.ATXB01000001_gene733	2.559e-17	85.0	COG3113@1|root,COG3113@2|Bacteria,1NGIE@1224|Proteobacteria,1SGH6@1236|Gammaproteobacteria,1XFQI@135618|Methylococcales	135618|Methylococcales	S	STAS domain	-	-	-	ko:K07122	ko02010,map02010	M00210	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27.3	-	-	STAS_2
HKD1_k127_1379316_11	395493.BegalDRAFT_3206	5.51e-79	271.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,460FK@72273|Thiotrichales	72273|Thiotrichales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_1379316_2	713586.KB900536_gene2636	7.981e-127	415.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,1RNZV@1236|Gammaproteobacteria,1WWTH@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_1379316_3	1049564.TevJSym_ao00250	1.882e-117	396.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,1RMWU@1236|Gammaproteobacteria,1J4I7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	surA	GO:0000413,GO:0003674,GO:0003755,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006457,GO:0006458,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016853,GO:0016859,GO:0018193,GO:0018208,GO:0019538,GO:0022607,GO:0030288,GO:0030313,GO:0031647,GO:0031975,GO:0033218,GO:0036211,GO:0042277,GO:0042597,GO:0043163,GO:0043165,GO:0043170,GO:0043412,GO:0044085,GO:0044091,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0044764,GO:0045229,GO:0050821,GO:0051082,GO:0051084,GO:0051085,GO:0051704,GO:0060274,GO:0061024,GO:0061077,GO:0065007,GO:0065008,GO:0071704,GO:0071709,GO:0071840,GO:0140096,GO:1901564	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3,SurA_N
HKD1_k127_1379316_0	396588.Tgr7_2714	1.044e-152	511.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,1RQEX@1236|Gammaproteobacteria,1WWF6@135613|Chromatiales	135613|Chromatiales	M	Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
HKD1_k127_1379316_20	396595.TK90_0073	1.415e-40	161.0	COG0631@1|root,COG0631@2|Bacteria,1N72S@1224|Proteobacteria,1SBH5@1236|Gammaproteobacteria,1WZC2@135613|Chromatiales	135613|Chromatiales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD1_k127_1379316_7	156889.Mmc1_1921	1.231e-97	349.0	COG0515@1|root,COG1262@1|root,COG3170@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG3170@2|Bacteria,1PJRR@1224|Proteobacteria,2U625@28211|Alphaproteobacteria	28211|Alphaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	DUF4189,PG_binding_1,Pkinase,WD40
HKD1_k127_1379316_21	748247.AZKH_2747	3.154e-38	145.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2VIP5@28216|Betaproteobacteria,2KVF2@206389|Rhodocyclales	206389|Rhodocyclales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_1379316_15	331869.BAL199_26996	9.432e-62	216.0	COG1024@1|root,COG1024@2|Bacteria,1MUJ7@1224|Proteobacteria,2TTMB@28211|Alphaproteobacteria,4BP9Q@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	PFAM Enoyl-CoA hydratase isomerase family	Echdc	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_1379316_14	1158146.KB907123_gene824	5.425e-62	216.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,1S3VS@1236|Gammaproteobacteria,1WY8U@135613|Chromatiales	135613|Chromatiales	U	general secretion pathway protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD1_k127_1379316_28	1328313.DS2_05235	1.688e-12	75.0	COG2165@1|root,COG2165@2|Bacteria,1N7HZ@1224|Proteobacteria,1SCWD@1236|Gammaproteobacteria,4672W@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	general secretion pathway protein	gspH	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K02457	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspH,N_methyl
HKD1_k127_1379316_25	1415779.JOMH01000001_gene1876	7.644e-19	92.0	COG4967@1|root,COG4967@2|Bacteria,1R1MP@1224|Proteobacteria,1T55P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NU	Type II secretion system (T2SS), protein I	-	-	-	ko:K02458	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSI
HKD1_k127_1379316_18	1304275.C41B8_02832	1.808e-43	168.0	COG4795@1|root,COG4795@2|Bacteria,1RJAE@1224|Proteobacteria,1S5ZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	General secretion pathway protein J	gspJ	GO:0002790,GO:0006810,GO:0008104,GO:0008150,GO:0009306,GO:0009987,GO:0015031,GO:0015628,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071806,GO:0098776	-	ko:K02459	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSJ
HKD1_k127_1403576_3	768671.ThimaDRAFT_4465	9.888e-31	123.0	2DMHJ@1|root,32RM0@2|Bacteria,1NDZ0@1224|Proteobacteria,1SEPY@1236|Gammaproteobacteria,1WZRE@135613|Chromatiales	135613|Chromatiales	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_1403576_1	1415779.JOMH01000001_gene2283	2.622e-108	366.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,1RQP7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	reverse transcriptase	-	-	-	-	-	-	-	-	-	-	-	-	RVT_1
HKD1_k127_1403576_5	768671.ThimaDRAFT_4463	9.6e-10	67.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria,1S2PN@1236|Gammaproteobacteria,1WYNY@135613|Chromatiales	135613|Chromatiales	KLT	PFAM Sulphatase-modifying factor	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,PG_binding_1,Pkinase
HKD1_k127_1403576_2	765913.ThidrDRAFT_1130	1.535e-47	179.0	COG0551@1|root,COG0551@2|Bacteria,1PZFI@1224|Proteobacteria,1RQ64@1236|Gammaproteobacteria,1WXVE@135613|Chromatiales	135613|Chromatiales	L	NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
HKD1_k127_1403576_4	314345.SPV1_06379	2.203e-21	106.0	2AX7M@1|root,31P6D@2|Bacteria,1RJD1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403576_0	1313172.YM304_34520	1.722e-123	404.0	COG2374@1|root,COG2374@2|Bacteria,2I2E0@201174|Actinobacteria	201174|Actinobacteria	M	endonuclease exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_3_5,Big_5,CW_binding_2,DUF3616,Exo_endo_phos,LTD
HKD1_k127_140368_2	472759.Nhal_1309	2.098e-172	548.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,1S118@1236|Gammaproteobacteria,1X0F2@135613|Chromatiales	135613|Chromatiales	I	Squalene-hopene cyclase N-terminal domain	-	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD1_k127_140368_9	472759.Nhal_1308	9.452e-36	147.0	COG0775@1|root,COG0775@2|Bacteria,1MY5S@1224|Proteobacteria,1RNSF@1236|Gammaproteobacteria,1WZQ1@135613|Chromatiales	135613|Chromatiales	F	other phosphorylase family 1	-	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_140368_10	1122169.AREN01000034_gene2819	1.788e-35	139.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,1S8YV@1236|Gammaproteobacteria,1JEIP@118969|Legionellales	118969|Legionellales	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD1_k127_140368_7	251221.35211938	2.123e-61	215.0	COG0822@1|root,COG0822@2|Bacteria,1G590@1117|Cyanobacteria	1117|Cyanobacteria	C	SUF system FeS assembly protein, NifU family	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_140368_1	1183438.GKIL_1933	3.459e-185	587.0	COG0520@1|root,COG0520@2|Bacteria,1G15D@1117|Cyanobacteria	1117|Cyanobacteria	E	Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_140368_4	945713.IALB_2895	2.969e-92	318.0	COG0719@1|root,COG0719@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
HKD1_k127_140368_3	314278.NB231_04915	8.394e-115	374.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,1RPFE@1236|Gammaproteobacteria,1WWC1@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD1_k127_140368_0	251221.35211934	1.574e-267	828.0	COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria	1117|Cyanobacteria	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_140368_8	187272.Mlg_0724	4.191e-36	142.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,1S915@1236|Gammaproteobacteria,1X1A7@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_140368_6	1234364.AMSF01000001_gene2362	1.527e-70	244.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,1S40D@1236|Gammaproteobacteria,1X50D@135614|Xanthomonadales	135614|Xanthomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD1_k127_140368_5	631362.Thi970DRAFT_04277	7.752e-84	282.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales	135613|Chromatiales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_1419730_2	357808.RoseRS_3158	5.02e-29	120.0	COG0732@1|root,COG0732@2|Bacteria,2G7K5@200795|Chloroflexi,377SZ@32061|Chloroflexia	2|Bacteria	V	type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
HKD1_k127_1419730_3	1123393.KB891317_gene2267	6.333e-17	83.0	2AFYE@1|root,31626@2|Bacteria,1PWQR@1224|Proteobacteria,2WC9B@28216|Betaproteobacteria,1KT9Z@119069|Hydrogenophilales	119069|Hydrogenophilales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1419730_0	1049564.TevJSym_ax00090	4.326e-219	696.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPCU@1236|Gammaproteobacteria,1J4ET@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	COG0488 ATPase components of ABC transporters with duplicated ATPase domains	uup	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008150,GO:0009314,GO:0009628,GO:0010528,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0031323,GO:0044424,GO:0044464,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0060255,GO:0065007,GO:0070894,GO:0071944,GO:0080090,GO:0097159,GO:1901363	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_1419730_4	357808.RoseRS_0703	1.837e-11	64.0	COG1168@1|root,COG1168@2|Bacteria,2G614@200795|Chloroflexi,375GA@32061|Chloroflexia	32061|Chloroflexia	E	PFAM aminotransferase, class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1444100_6	103690.17131263	8.528e-30	120.0	COG2442@1|root,COG2442@2|Bacteria,1G8BN@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_1444100_5	272123.Anacy_3660	4.575e-35	140.0	COG4634@1|root,COG4634@2|Bacteria,1G7JV@1117|Cyanobacteria,1HPBK@1161|Nostocales	1117|Cyanobacteria	S	Mut7-C RNAse domain	-	-	-	-	-	-	-	-	-	-	-	-	Mut7-C
HKD1_k127_1444100_4	323261.Noc_0768	4.125e-68	235.0	COG1943@1|root,COG1943@2|Bacteria,1RCWW@1224|Proteobacteria,1S3ZJ@1236|Gammaproteobacteria,1WY9M@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_1444100_2	713586.KB900536_gene2892	3.399e-132	426.0	COG1469@1|root,COG1469@2|Bacteria,1MV1B@1224|Proteobacteria,1RNDY@1236|Gammaproteobacteria,1WW3H@135613|Chromatiales	135613|Chromatiales	S	Converts GTP to 7,8-dihydroneopterin triphosphate	folE2	-	3.5.4.16	ko:K09007	ko00790,ko01100,map00790,map01100	M00126	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GCHY-1
HKD1_k127_1444100_0	472759.Nhal_1241	6.474e-297	923.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,1RNQD@1236|Gammaproteobacteria,1WWHQ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_1444100_3	396588.Tgr7_0833	2.603e-122	398.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,1RMKY@1236|Gammaproteobacteria,1WX2E@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K00795,ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_1444100_7	1523503.JPMY01000028_gene304	3.135e-21	95.0	COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD1_k127_1444100_1	313628.LNTAR_19612	1.579e-145	488.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_1455805_7	765913.ThidrDRAFT_2930	1.366e-35	136.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales	135613|Chromatiales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_1455805_5	1121957.ATVL01000008_gene4470	9.719e-55	199.0	COG0702@1|root,COG0702@2|Bacteria,4NG89@976|Bacteroidetes,47PTQ@768503|Cytophagia	976|Bacteroidetes	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HKD1_k127_1455805_9	1175306.GWL_05220	6.241e-25	112.0	COG1280@1|root,COG1280@2|Bacteria,1MX0K@1224|Proteobacteria,2VR6Z@28216|Betaproteobacteria,477HZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD1_k127_1455805_1	768671.ThimaDRAFT_0614	6.702e-100	338.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1WXGI@135613|Chromatiales	135613|Chromatiales	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	SPOR,YkuD
HKD1_k127_1455805_15	1504672.669783984	0.0005064	46.0	COG2522@1|root,COG2522@2|Bacteria,1N1H4@1224|Proteobacteria,2VWXH@28216|Betaproteobacteria	28216|Betaproteobacteria	O	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1455805_8	335541.Swol_1985	7.633e-31	124.0	COG1917@1|root,COG1917@2|Bacteria,1V6IB@1239|Firmicutes,24JTU@186801|Clostridia	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_1455805_3	1458357.BG58_11705	3.5e-88	308.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,2VKJ8@28216|Betaproteobacteria,1K363@119060|Burkholderiaceae	28216|Betaproteobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_1455805_2	1121935.AQXX01000132_gene2676	1.455e-99	334.0	COG5000@1|root,COG5000@2|Bacteria,1R45S@1224|Proteobacteria,1RY7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Protein of unknown function (DUF3365)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP
HKD1_k127_1455805_10	870187.Thini_2693	6.242e-17	89.0	2ES2F@1|root,33JMD@2|Bacteria,1NQFF@1224|Proteobacteria,1SJHV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1455805_13	1121004.ATVC01000074_gene1223	6.66e-10	66.0	COG1943@1|root,COG1943@2|Bacteria,1RDD7@1224|Proteobacteria,2VS0W@28216|Betaproteobacteria,2KSYT@206351|Neisseriales	206351|Neisseriales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_1455805_14	349521.HCH_00241	5.936e-07	57.0	COG1075@1|root,COG1075@2|Bacteria,1R88U@1224|Proteobacteria,1S0MF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	PGAP1
HKD1_k127_1455805_0	1122604.JONR01000034_gene430	6.521e-166	533.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1X3UF@135614|Xanthomonadales	135614|Xanthomonadales	JKL	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_1455805_6	1382359.JIAL01000001_gene2052	7.988e-36	139.0	COG1064@1|root,COG1064@2|Bacteria,3Y33B@57723|Acidobacteria,2JI1P@204432|Acidobacteriia	204432|Acidobacteriia	S	Zinc-binding dehydrogenase	-	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1455805_4	395492.Rleg2_2045	2.503e-58	205.0	COG0583@1|root,COG0583@2|Bacteria,1MU2E@1224|Proteobacteria,2TUNU@28211|Alphaproteobacteria,4B73Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_1455805_11	1006000.GKAS_00510	2.51e-15	80.0	COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,1S08N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	-	-	-	ko:K14060	-	-	-	-	ko00000	-	-	-	HTH_7,Resolvase
HKD1_k127_1455805_12	391735.Veis_1405	1.04e-13	76.0	2C6Q2@1|root,303KN@2|Bacteria,1RD5V@1224|Proteobacteria,2VRYD@28216|Betaproteobacteria,4AFSY@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1457615_11	1049564.TevJSym_bk00050	1.237e-16	80.0	COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1JBAT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_1457615_8	395493.BegalDRAFT_2974	4.91e-43	168.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S364@1236|Gammaproteobacteria,463EC@72273|Thiotrichales	72273|Thiotrichales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_1457615_0	314278.NB231_10753	3.654e-82	282.0	COG3568@1|root,COG3568@2|Bacteria,1RBWV@1224|Proteobacteria,1S296@1236|Gammaproteobacteria,1X2D7@135613|Chromatiales	135613|Chromatiales	L	Endonuclease Exonuclease phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_1457615_6	626887.J057_09916	2.235e-48	180.0	COG1651@1|root,COG1651@2|Bacteria,1RGWH@1224|Proteobacteria,1S5WA@1236|Gammaproteobacteria,466ZK@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	COG0526 Thiol-disulfide isomerase and thioredoxins	dsbA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	ko:K03673	ko01503,map01503	M00728	-	-	ko00000,ko00001,ko00002,ko03110	-	-	-	DSBA,Thioredoxin_4
HKD1_k127_1457615_3	1266908.AQPB01000061_gene1263	1.523e-66	233.0	COG2863@1|root,COG2863@2|Bacteria,1N2NB@1224|Proteobacteria,1RZFP@1236|Gammaproteobacteria,1WYDI@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome c, class I	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_1457615_2	314278.NB231_10768	1.562e-72	252.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,1RNJP@1236|Gammaproteobacteria,1WWX9@135613|Chromatiales	135613|Chromatiales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD1_k127_1457615_7	1499967.BAYZ01000118_gene3301	7.959e-44	162.0	COG1359@1|root,COG1359@2|Bacteria	2|Bacteria	S	Antibiotic biosynthesis monooxygenase	lsrG	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HKD1_k127_1457615_1	395493.BegalDRAFT_0735	4.539e-81	278.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,1RRFJ@1236|Gammaproteobacteria,462B7@72273|Thiotrichales	72273|Thiotrichales	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	-	-	-	-	-	-	-	-	-	CcmB
HKD1_k127_1457615_4	28152.DJ57_587	2.352e-62	220.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,1S3R2@1236|Gammaproteobacteria,41D3P@629|Yersinia	1236|Gammaproteobacteria	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006810,GO:0008150,GO:0009898,GO:0015232,GO:0015886,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019897,GO:0019898,GO:0022857,GO:0031224,GO:0031234,GO:0032991,GO:0042623,GO:0043190,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0098533,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:1901678,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	iAPECO1_1312.APECO1_4358,iECED1_1282.ECED1_2666,iECS88_1305.ECS88_2348,iECUMN_1333.ECUMN_2536,iLF82_1304.LF82_0273,iNRG857_1313.NRG857_11170,iUMN146_1321.UM146_05800,iUTI89_1310.UTI89_C2479	ABC_tran
HKD1_k127_1457615_5	1249627.D779_4139	8.337e-56	211.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,1RZEA@1236|Gammaproteobacteria,1WWTV@135613|Chromatiales	135613|Chromatiales	O	TIGRFAM Cytochrome c-type biogenesis protein CcmI	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
HKD1_k127_1457615_9	1122201.AUAZ01000003_gene1868	8.38e-38	150.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,1S9DV@1236|Gammaproteobacteria,467TB@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	subunit of a heme lyase	ccmH	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015035,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567	-	ko:K02200,ko:K04017	-	-	-	-	ko00000	-	-	-	CcmH
HKD1_k127_1457615_10	243924.LT42_08625	3.374e-25	106.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,1S5YV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	Thiol disulfide interchange protein	dsbE	GO:0003674,GO:0003756,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0009897,GO:0009986,GO:0009987,GO:0015036,GO:0016020,GO:0016043,GO:0016491,GO:0016667,GO:0016853,GO:0016860,GO:0016864,GO:0017004,GO:0022607,GO:0031224,GO:0031226,GO:0031233,GO:0031237,GO:0034622,GO:0043933,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0055114,GO:0065003,GO:0071840,GO:0071944,GO:0098552,GO:0098567,GO:0140096	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	Redoxin
HKD1_k127_1463273_0	998674.ATTE01000001_gene3666	3.135e-122	396.0	COG2192@1|root,COG2192@2|Bacteria,1MWBA@1224|Proteobacteria,1RNN4@1236|Gammaproteobacteria,45ZSA@72273|Thiotrichales	72273|Thiotrichales	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD1_k127_1463273_3	82654.Pse7367_2151	2.67e-31	126.0	2DP8V@1|root,33122@2|Bacteria,1G83J@1117|Cyanobacteria,1HB8R@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1463273_4	765913.ThidrDRAFT_4139	2.57e-19	89.0	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,1SHN2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1463273_5	1120970.AUBZ01000002_gene730	1.883e-14	80.0	2C668@1|root,32W8B@2|Bacteria,1N0CT@1224|Proteobacteria,1SA1B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD1_k127_1463273_1	398767.Glov_0644	6.751e-119	390.0	COG3608@1|root,COG3608@2|Bacteria,1MUAA@1224|Proteobacteria,42QG8@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	succinylglutamate desuccinylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HKD1_k127_1463273_2	398767.Glov_0643	4.607e-63	220.0	COG3608@1|root,COG3608@2|Bacteria,1RG3Y@1224|Proteobacteria,42R0N@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HKD1_k127_147456_13	1173024.KI912148_gene4313	1.614e-20	94.0	COG1961@1|root,COG1961@2|Bacteria,1G266@1117|Cyanobacteria,1JKFH@1189|Stigonemataceae	1117|Cyanobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_147456_12	118166.JH976537_gene4100	2.178e-29	127.0	COG1961@1|root,COG1961@2|Bacteria,1G266@1117|Cyanobacteria,1HEYW@1150|Oscillatoriales	1117|Cyanobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_147456_7	41431.PCC8801_4426	4.776e-66	235.0	COG1305@1|root,COG1305@2|Bacteria,1G2WU@1117|Cyanobacteria,3KHEB@43988|Cyanothece	1117|Cyanobacteria	E	PFAM transglutaminase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_147456_10	395493.BegalDRAFT_0369	3.268e-46	174.0	COG2834@1|root,COG2834@2|Bacteria,1PXDV@1224|Proteobacteria,1S9FW@1236|Gammaproteobacteria,460XC@72273|Thiotrichales	72273|Thiotrichales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	ko:K03634	-	-	-	-	ko00000	-	-	-	LolA
HKD1_k127_147456_3	1026882.MAMP_01644	1.422e-196	621.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,1RPBY@1236|Gammaproteobacteria,4606R@72273|Thiotrichales	72273|Thiotrichales	L	ATPase (AAA	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_147456_1	187272.Mlg_0071	1.69e-238	748.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,1RNQM@1236|Gammaproteobacteria,1WWEC@135613|Chromatiales	135613|Chromatiales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD1_k127_147456_11	472759.Nhal_2365	6.331e-43	165.0	COG3165@1|root,COG3165@2|Bacteria,1R1CM@1224|Proteobacteria,1S1SM@1236|Gammaproteobacteria,1WWJP@135613|Chromatiales	135613|Chromatiales	S	Sterol-binding domain protein	-	-	-	ko:K03690	-	-	-	-	ko00000	-	-	-	SCP2
HKD1_k127_147456_4	713586.KB900536_gene2189	9.192e-116	378.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,1RMAU@1236|Gammaproteobacteria,1WWSM@135613|Chromatiales	135613|Chromatiales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_147456_9	545276.KB898729_gene1658	1.987e-54	192.0	COG3536@1|root,COG3536@2|Bacteria,1MZ5M@1224|Proteobacteria,1S8TB@1236|Gammaproteobacteria,1WYD9@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HKD1_k127_147456_2	396588.Tgr7_0057	1.104e-211	665.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,1RMYV@1236|Gammaproteobacteria,1WWCI@135613|Chromatiales	135613|Chromatiales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD1_k127_147456_6	395493.BegalDRAFT_1901	9.223e-83	279.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,1RP7P@1236|Gammaproteobacteria,460JZ@72273|Thiotrichales	72273|Thiotrichales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD1_k127_147456_0	765913.ThidrDRAFT_0772	1.014e-246	777.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,1WW1S@135613|Chromatiales	135613|Chromatiales	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_147456_8	1454004.AW11_00394	1.517e-57	203.0	COG4564@1|root,COG4564@2|Bacteria,1RFW5@1224|Proteobacteria,2VTWN@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	sCache_2
HKD1_k127_147456_14	748247.AZKH_0948	7.393e-07	61.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria	1224|Proteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_147456_5	533247.CRD_02152	4.138e-112	365.0	COG2192@1|root,COG2192@2|Bacteria,1G1FV@1117|Cyanobacteria,1HS2E@1161|Nostocales	1117|Cyanobacteria	O	Carbamoyltransferase C-terminus	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD1_k127_1538764_7	631362.Thi970DRAFT_04683	7.151e-49	177.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales	135613|Chromatiales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD1_k127_1538764_11	314278.NB231_16003	1.955e-17	86.0	COG2965@1|root,COG2965@2|Bacteria,1RHIE@1224|Proteobacteria,1S6H5@1236|Gammaproteobacteria,1X20V@135613|Chromatiales	135613|Chromatiales	L	Binds single-stranded DNA at the primosome assembly site (PAS)	priB	-	-	ko:K02686	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SSB
HKD1_k127_1538764_10	105559.Nwat_2899	1.393e-37	141.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,1WYXU@135613|Chromatiales	135613|Chromatiales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD1_k127_1538764_8	765911.Thivi_1183	6.493e-46	177.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1WXMV@135613|Chromatiales	135613|Chromatiales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HKD1_k127_1538764_6	1001585.MDS_0723	1.111e-51	188.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,1S3WS@1236|Gammaproteobacteria,1YG0J@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0019843,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0070180,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD1_k127_1538764_1	105559.Nwat_2604	1.819e-231	724.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria,1WWEY@135613|Chromatiales	135613|Chromatiales	C	FAD linked oxidase	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1538764_4	395493.BegalDRAFT_1616	2.187e-137	472.0	COG1196@1|root,COG1196@2|Bacteria,1R4SX@1224|Proteobacteria,1RVI9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Domain of Unknown Function (DUF349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF349
HKD1_k127_1538764_2	1499967.BAYZ01000003_gene5883	1.126e-145	469.0	COG2008@1|root,COG2008@2|Bacteria,2NNMP@2323|unclassified Bacteria	2|Bacteria	E	aromatic amino acid beta-eliminating lyase threonine aldolase	ltaE	GO:0003674,GO:0003824,GO:0004793,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006566,GO:0006567,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008732,GO:0009056,GO:0009063,GO:0009066,GO:0009068,GO:0009987,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019752,GO:0019842,GO:0030170,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050179,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	iECNA114_1301.ECNA114_0812,iECSF_1327.ECSF_0795	Beta_elim_lyase
HKD1_k127_1538764_0	1038859.AXAU01000001_gene3133	3.092e-286	917.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
HKD1_k127_1538764_3	1242864.D187_003605	3.445e-139	453.0	COG1944@1|root,COG1944@2|Bacteria,1N5NV@1224|Proteobacteria,42VNR@68525|delta/epsilon subdivisions,2WSCG@28221|Deltaproteobacteria,2YXER@29|Myxococcales	28221|Deltaproteobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
HKD1_k127_1538764_5	1278073.MYSTI_06271	9.099e-97	332.0	COG3482@1|root,COG3482@2|Bacteria,1QG2J@1224|Proteobacteria,43BG1@68525|delta/epsilon subdivisions,2X6UC@28221|Deltaproteobacteria,2YTYR@29|Myxococcales	28221|Deltaproteobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
HKD1_k127_1538764_9	41431.PCC8801_1335	2.213e-39	151.0	COG3590@1|root,COG3590@2|Bacteria,1GGZB@1117|Cyanobacteria	1117|Cyanobacteria	O	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1545368_2	443598.AUFA01000004_gene5357	1.741e-231	724.0	COG1902@1|root,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2U2EY@28211|Alphaproteobacteria,3K3R1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD1_k127_1545368_6	317936.Nos7107_4358	3.01e-148	487.0	COG1858@1|root,COG1858@2|Bacteria,1G1X0@1117|Cyanobacteria	1117|Cyanobacteria	C	cytochrome C peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_1545368_14	472759.Nhal_1346	4.699e-19	91.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CCP_MauG,FG-GAP,UnbV_ASPIC,VCBS
HKD1_k127_1545368_4	65393.PCC7424_4647	8.504e-198	629.0	COG2010@1|root,COG2010@2|Bacteria,1FZVJ@1117|Cyanobacteria,3KHDZ@43988|Cyanothece	1117|Cyanobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_1545368_5	1121935.AQXX01000069_gene5900	8.019e-188	601.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria,1XK0D@135619|Oceanospirillales	135619|Oceanospirillales	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD1_k127_1545368_9	485913.Krac_0576	8.002e-128	417.0	COG0451@1|root,COG0451@2|Bacteria,2G8UC@200795|Chloroflexi	200795|Chloroflexi	M	NmrA-like family	-	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase
HKD1_k127_1545368_0	314278.NB231_07942	3.01e-279	867.0	COG0529@1|root,COG2046@1|root,COG0529@2|Bacteria,COG2046@2|Bacteria,1MUQB@1224|Proteobacteria,1RP4Q@1236|Gammaproteobacteria,1WWF2@135613|Chromatiales	135613|Chromatiales	P	Belongs to the sulfate adenylyltransferase family	cysC	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,ATP-sulfurylase,PUA_2
HKD1_k127_1545368_11	76114.ebA6799	3.96e-52	194.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VIY9@28216|Betaproteobacteria,2KYDR@206389|Rhodocyclales	206389|Rhodocyclales	M	Polysaccharide biosynthesis/export protein	gumB	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_1545368_3	323261.Noc_1497	9.732e-209	673.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,1RNB0@1236|Gammaproteobacteria,1WXXC@135613|Chromatiales	135613|Chromatiales	D	Capsular exopolysaccharide family	-	-	-	ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HKD1_k127_1545368_10	323261.Noc_1499	4.758e-102	346.0	COG0457@1|root,COG0457@2|Bacteria,1RD7S@1224|Proteobacteria,1T3Z6@1236|Gammaproteobacteria,1WZY0@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1545368_8	323261.Noc_1503	3.376e-130	432.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,1RQWW@1236|Gammaproteobacteria,1WZJ1@135613|Chromatiales	135613|Chromatiales	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD1_k127_1545368_12	595536.ADVE02000001_gene1167	1.453e-51	195.0	COG1493@1|root,COG1493@2|Bacteria,1RE0J@1224|Proteobacteria,2U8MR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_C
HKD1_k127_1545368_13	1207063.P24_10221	2.018e-49	180.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2U9BM@28211|Alphaproteobacteria,2JTJ5@204441|Rhodospirillales	204441|Rhodospirillales	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_1545368_7	1288494.EBAPG3_9000	5.699e-132	430.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2VJ6H@28216|Betaproteobacteria,372R9@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_1545368_1	1049564.TevJSym_bm00130	2.379e-244	767.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,1RNGV@1236|Gammaproteobacteria,1J4GN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009380,GO:0009381,GO:0009628,GO:0009987,GO:0016787,GO:0016788,GO:0032991,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD1_k127_1547338_0	56107.Cylst_2351	3.146e-59	231.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HJAG@1161|Nostocales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_1551660_0	261292.Nit79A3_3038	1.787e-87	309.0	COG0642@1|root,COG0784@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,1MUY7@1224|Proteobacteria,2VIXT@28216|Betaproteobacteria	28216|Betaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Response_reg
HKD1_k127_1551870_1	448385.sce5680	8.112e-45	171.0	COG1353@1|root,COG1353@2|Bacteria,1RC0I@1224|Proteobacteria	1224|Proteobacteria	S	crispr-associated protein	-	-	-	ko:K19076	-	-	-	-	ko00000,ko02048	-	-	-	DUF3692
HKD1_k127_1551870_0	472759.Nhal_1824	1.408e-184	585.0	COG1403@1|root,COG1403@2|Bacteria,1QE4E@1224|Proteobacteria,1RS5S@1236|Gammaproteobacteria,1WZVU@135613|Chromatiales	135613|Chromatiales	L	SMART HNH nuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5,RRXRR
HKD1_k127_1551870_2	935948.KE386493_gene2491	9.15e-36	143.0	COG0419@1|root,COG0419@2|Bacteria,1VJ2K@1239|Firmicutes,24TD5@186801|Clostridia	186801|Clostridia	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1551870_3	448385.sce5677	7.543e-05	51.0	2A0YC@1|root,32DZ6@2|Bacteria,1QR71@1224|Proteobacteria,4359J@68525|delta/epsilon subdivisions,2WZKQ@28221|Deltaproteobacteria,2Z2BT@29|Myxococcales	28221|Deltaproteobacteria	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
HKD1_k127_1552054_0	221288.JH992901_gene3912	0.0	1768.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria,1JJJW@1189|Stigonemataceae	1117|Cyanobacteria	Q	Ketoacyl-synthetase C-terminal extension	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,ketoacyl-synt
HKD1_k127_1552054_7	983917.RGE_31220	3.369e-76	267.0	COG1502@1|root,COG1502@2|Bacteria,1RBSH@1224|Proteobacteria,2W1N5@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_1552054_6	1174528.JH992892_gene6289	3.034e-77	269.0	COG0500@1|root,COG2226@2|Bacteria,1G364@1117|Cyanobacteria	1117|Cyanobacteria	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_1552054_4	987059.RBXJA2T_11932	1.224e-78	273.0	COG1502@1|root,COG1502@2|Bacteria,1RBSH@1224|Proteobacteria,2W1N5@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_1552054_9	261292.Nit79A3_2110	9.27e-70	247.0	COG1502@1|root,COG1502@2|Bacteria,1RBSH@1224|Proteobacteria,2W1N5@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_1552054_10	1123373.ATXI01000002_gene710	3.521e-18	96.0	COG2227@1|root,COG2227@2|Bacteria,2GI92@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_1552054_5	987059.RBXJA2T_11932	3.732e-78	273.0	COG1502@1|root,COG1502@2|Bacteria,1RBSH@1224|Proteobacteria,2W1N5@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_1552054_8	378806.STAUR_8024	1.628e-72	268.0	COG0657@1|root,COG0657@2|Bacteria	2|Bacteria	I	acetylesterase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1552054_11	195250.CM001776_gene3652	1.548e-17	85.0	COG5464@1|root,COG5464@2|Bacteria,1G2UF@1117|Cyanobacteria,1H2QF@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF4351)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351
HKD1_k127_1552054_1	1121405.dsmv_0277	1.262e-205	644.0	COG3177@1|root,COG3177@2|Bacteria,1MV69@1224|Proteobacteria,42MWV@68525|delta/epsilon subdivisions,2WJJZ@28221|Deltaproteobacteria,2MMNZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	filamentation induced by cAMP protein Fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic,Fic_N,HTH_24
HKD1_k127_1552054_3	243233.MCA2639	1.729e-82	275.0	COG3311@1|root,COG3311@2|Bacteria,1R8IB@1224|Proteobacteria,1S5VF@1236|Gammaproteobacteria,1XGHA@135618|Methylococcales	135618|Methylococcales	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD1_k127_1552054_2	375286.mma_2686	5.385e-109	354.0	COG1569@1|root,COG1569@2|Bacteria,1RCZE@1224|Proteobacteria,2W9UM@28216|Betaproteobacteria,477DC@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HKD1_k127_1552054_12	946483.Cenrod_0255	8.127e-07	56.0	COG4916@1|root,COG4916@2|Bacteria,1RBBR@1224|Proteobacteria,2VTPZ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2,TIR_2
HKD1_k127_1552606_5	472759.Nhal_3985	3.174e-12	66.0	COG1662@1|root,COG1662@2|Bacteria,1NFF1@1224|Proteobacteria,1SEGH@1236|Gammaproteobacteria,1WZDG@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1
HKD1_k127_1552606_4	489825.LYNGBM3L_22820	1.992e-15	79.0	COG3415@1|root,COG3415@2|Bacteria,1GQZ0@1117|Cyanobacteria,1HI55@1150|Oscillatoriales	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_33
HKD1_k127_1552606_3	224325.AF_1352	2.255e-17	84.0	COG3335@1|root,arCOG02129@2157|Archaea,2XUWJ@28890|Euryarchaeota	28890|Euryarchaeota	L	Transposase and inactivated derivatives	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_32,HTH_33
HKD1_k127_1552606_6	1532558.JL39_28285	2.389e-10	66.0	COG4190@1|root,COG4190@2|Bacteria,1NFUE@1224|Proteobacteria,2UIY7@28211|Alphaproteobacteria,4BFY2@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD1_k127_1552606_1	1163617.SCD_n00207	1.951e-30	122.0	2E33J@1|root,32Y3P@2|Bacteria,1N9JJ@1224|Proteobacteria,2VXE1@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1552606_0	1122604.JONR01000001_gene1686	5.559e-140	463.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1X4ZI@135614|Xanthomonadales	135614|Xanthomonadales	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HKD1_k127_1552606_2	671143.DAMO_0659	1.38e-19	98.0	COG5373@1|root,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	ko:K02451,ko:K03832	-	M00331	-	-	ko00000,ko00002,ko02000,ko02044	2.C.1.1,9.B.42	-	-	T2SSB
HKD1_k127_1558706_1	1449069.JMLO01000003_gene4137	6.76e-39	157.0	2DPYR@1|root,33401@2|Bacteria,2IJC2@201174|Actinobacteria,4G3X0@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4231
HKD1_k127_1558706_0	1499967.BAYZ01000193_gene3904	5.889e-71	247.0	2AR01@1|root,31G8U@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1558706_3	1122201.AUAZ01000005_gene541	1.066e-15	78.0	COG1024@1|root,COG1024@2|Bacteria,1MVEC@1224|Proteobacteria,1RP85@1236|Gammaproteobacteria,465S5@72275|Alteromonadaceae	1236|Gammaproteobacteria	I	COG1024 Enoyl-CoA hydratase carnithine racemase	liuC	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_1558706_2	1458357.BG58_40935	1.195e-31	126.0	COG3921@1|root,COG3921@2|Bacteria,1QWJX@1224|Proteobacteria	1224|Proteobacteria	S	D-alanyl-D-alanine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_4
HKD1_k127_1561987_6	105559.Nwat_0227	4.39e-121	398.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,1RMQ3@1236|Gammaproteobacteria,1WWB9@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_1561987_5	754476.Q7A_1015	8.197e-127	418.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,1RMIV@1236|Gammaproteobacteria,45ZND@72273|Thiotrichales	72273|Thiotrichales	M	Peptidoglycan polymerase that is essential for cell division	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_1561987_2	765912.Thimo_3113	1.103e-149	486.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,1RP25@1236|Gammaproteobacteria,1WWI1@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_1561987_1	1049564.TevJSym_aj00330	1.021e-168	537.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,1RNIG@1236|Gammaproteobacteria,1J574@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	GO:0000270,GO:0003674,GO:0003824,GO:0005575,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008963,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0030203,GO:0034645,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	iEC042_1314.EC042_0088,iECABU_c1320.ECABU_c00920,iECED1_1282.ECED1_0088,iECH74115_1262.ECH74115_0095,iECSP_1301.ECSP_0090,iECs_1301.ECs0091,iG2583_1286.G2583_0091,iSDY_1059.SDY_0117,iZ_1308.Z0097,ic_1306.c0105	Glycos_transf_4,MraY_sig1
HKD1_k127_1561987_3	713586.KB900536_gene1377	5.167e-131	434.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,1RMGD@1236|Gammaproteobacteria,1WWTC@135613|Chromatiales	135613|Chromatiales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_1561987_0	519989.ECTPHS_01844	6.184e-191	612.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,1RNGW@1236|Gammaproteobacteria,1WWDS@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall at the division septum	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_1561987_11	396588.Tgr7_0762	8.497e-11	70.0	COG3116@1|root,COG3116@2|Bacteria,1NI3C@1224|Proteobacteria,1SGSB@1236|Gammaproteobacteria,1WZ00@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsL	-	-	ko:K03586	-	-	-	-	ko00000,ko03036	-	-	-	FtsL
HKD1_k127_1561987_7	396588.Tgr7_0761	7.4e-108	358.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,1RM7M@1236|Gammaproteobacteria,1WX5B@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_1561987_9	1260251.SPISAL_06875	1.68e-60	212.0	COG2001@1|root,COG2001@2|Bacteria,1RHCG@1224|Proteobacteria,1S63F@1236|Gammaproteobacteria,1WYVR@135613|Chromatiales	135613|Chromatiales	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_1561987_10	272624.lpg1742	2.013e-24	107.0	2E9J1@1|root,333RY@2|Bacteria,1NIX0@1224|Proteobacteria,1SGM0@1236|Gammaproteobacteria,1JFBK@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1561987_4	765912.Thimo_1261	3.659e-130	421.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WZ7F@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM ATP phosphoribosyltransferase, C-terminal domain	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD1_k127_1561987_8	1027273.GZ77_12740	5.07e-96	322.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,1RNAR@1236|Gammaproteobacteria,1XHE4@135619|Oceanospirillales	135619|Oceanospirillales	J	Ribosomal protein L11 methyltransferase	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD1_k127_1594164_14	317619.ANKN01000155_gene2762	3.284e-05	48.0	COG3344@1|root,COG3344@2|Bacteria,1G2NC@1117|Cyanobacteria	1117|Cyanobacteria	L	reverse transcriptase	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,HNH,RVT_1,RVT_N
HKD1_k127_1594164_7	671143.DAMO_3092	1.462e-45	168.0	COG5499@1|root,COG5499@2|Bacteria,2NRMJ@2323|unclassified Bacteria	2|Bacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K18831	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	-
HKD1_k127_1594164_10	313624.NSP_5230	8.242e-41	153.0	COG4680@1|root,COG4680@2|Bacteria,1G7BW@1117|Cyanobacteria,1HPS5@1161|Nostocales	1117|Cyanobacteria	S	HigB_toxin, RelE-like toxic component of a toxin-antitoxin system	-	-	-	ko:K19166	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HigB_toxin
HKD1_k127_1594164_3	1123368.AUIS01000018_gene695	1.386e-129	435.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,2NC3T@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_1594164_6	1158182.KB905020_gene1693	3.412e-71	247.0	COG1926@1|root,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,1S3SH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_1594164_8	765914.ThisiDRAFT_0398	2.152e-43	160.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales	135613|Chromatiales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_1594164_0	713586.KB900536_gene2557	2.313e-265	825.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_1594164_4	314278.NB231_14011	4.402e-120	391.0	COG2607@1|root,COG2607@2|Bacteria,1MVMX@1224|Proteobacteria,1RQKK@1236|Gammaproteobacteria,1WWDF@135613|Chromatiales	135613|Chromatiales	S	ATPase (AAA superfamily)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD1_k127_1594164_13	748658.KB907312_gene1202	7.187e-31	125.0	COG0236@1|root,COG0236@2|Bacteria,1N6RU@1224|Proteobacteria,1SCW1@1236|Gammaproteobacteria,1WZ77@135613|Chromatiales	135613|Chromatiales	IQ	Phosphopantetheine attachment site	-	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_1594164_5	545276.KB898731_gene2252	6.847e-107	354.0	COG4261@1|root,COG4261@2|Bacteria,1MVXJ@1224|Proteobacteria,1RNKV@1236|Gammaproteobacteria,1WW87@135613|Chromatiales	135613|Chromatiales	S	Bacterial lipid A biosynthesis acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Lip_A_acyltrans
HKD1_k127_1594164_9	478741.JAFS01000001_gene1305	8.9e-42	163.0	COG1434@1|root,COG1434@2|Bacteria	2|Bacteria	S	Gram-negative-bacterium-type cell wall biogenesis	sanA	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_1594164_12	1366050.N234_30000	1.105e-32	131.0	COG4706@1|root,COG4706@2|Bacteria,1RIH4@1224|Proteobacteria,2VT0K@28216|Betaproteobacteria,1K7TQ@119060|Burkholderiaceae	28216|Betaproteobacteria	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1594164_11	580332.Slit_0367	8.565e-41	158.0	COG2834@1|root,COG2834@2|Bacteria,1RHYN@1224|Proteobacteria,2VSXY@28216|Betaproteobacteria,44WC9@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	LolA
HKD1_k127_1594164_1	296591.Bpro_3301	1.459e-150	504.0	COG4258@1|root,COG4258@2|Bacteria,1MU1E@1224|Proteobacteria,2VHXY@28216|Betaproteobacteria,4AB7F@80864|Comamonadaceae	28216|Betaproteobacteria	S	exporter	-	-	-	-	-	-	-	-	-	-	-	-	MMPL
HKD1_k127_1594164_2	555778.Hneap_2239	1.161e-138	449.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,1RMPP@1236|Gammaproteobacteria,1WXR7@135613|Chromatiales	135613|Chromatiales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.41	ko:K00647	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_1610438_2	765914.ThisiDRAFT_0269	1.549e-68	241.0	COG1394@1|root,COG1394@2|Bacteria,1PA1A@1224|Proteobacteria,1S17V@1236|Gammaproteobacteria,1WWE8@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD1_k127_1610438_7	525903.Taci_0516	7.231e-24	111.0	COG1156@1|root,COG1156@2|Bacteria,3TA7B@508458|Synergistetes	508458|Synergistetes	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	-	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_1610438_0	324925.Ppha_1233	1.715e-92	313.0	COG0464@1|root,COG0464@2|Bacteria,1FDHM@1090|Chlorobi	1090|Chlorobi	O	PFAM AAA ATPase central domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_1610438_3	1123288.SOV_2c06910	3.355e-47	175.0	COG0602@1|root,COG0602@2|Bacteria,1V1HG@1239|Firmicutes	1239|Firmicutes	O	Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	-	-	1.97.1.4	ko:K04068	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_1610438_5	111780.Sta7437_0528	2.724e-30	121.0	COG2026@1|root,COG2026@2|Bacteria,1GKH4@1117|Cyanobacteria,3VN3E@52604|Pleurocapsales	1117|Cyanobacteria	DJ	PFAM Plasmid stabilisation system protein	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_1610438_8	572477.Alvin_1696	1.675e-10	64.0	COG2161@1|root,COG2161@2|Bacteria,1NDJX@1224|Proteobacteria,1TK4V@1236|Gammaproteobacteria,1WZGB@135613|Chromatiales	135613|Chromatiales	D	toxin-antitoxin pair type II binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1610438_6	290315.Clim_1029	5.373e-24	108.0	COG0443@1|root,COG0443@2|Bacteria,1FDAK@1090|Chlorobi	1090|Chlorobi	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
HKD1_k127_1610438_9	517417.Cpar_1417	3.63e-06	55.0	COG0443@1|root,COG0443@2|Bacteria,1FDAK@1090|Chlorobi	1090|Chlorobi	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
HKD1_k127_1610438_1	517417.Cpar_1417	4.542e-85	293.0	COG0443@1|root,COG0443@2|Bacteria,1FDAK@1090|Chlorobi	1090|Chlorobi	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
HKD1_k127_1610438_10	517417.Cpar_1416	3.86e-05	51.0	COG0576@1|root,COG0576@2|Bacteria,1FF53@1090|Chlorobi	1090|Chlorobi	O	GrpE	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_1610438_4	489825.LYNGBM3L_70800	3.098e-37	145.0	COG0732@1|root,COG0732@2|Bacteria,1G1K5@1117|Cyanobacteria,1HAGE@1150|Oscillatoriales	1117|Cyanobacteria	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_162013_1	519989.ECTPHS_06582	3.676e-96	324.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1WXM6@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_162013_0	1158165.KB898872_gene860	1.542e-157	509.0	COG0644@1|root,COG0644@2|Bacteria,1MZVI@1224|Proteobacteria,1RMNS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	oxidoreductase	pltM	-	1.14.19.49	ko:K14257	ko00253,ko00404,ko01057,ko01130,map00253,map00404,map01057,map01130	M00790,M00823	R05456,R11106,R11478	RC00949	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_halogenase
HKD1_k127_162013_4	105559.Nwat_0961	4.356e-10	64.0	COG0251@1|root,COG0251@2|Bacteria,1NQGP@1224|Proteobacteria,1S2VU@1236|Gammaproteobacteria,1WYNS@135613|Chromatiales	135613|Chromatiales	J	pteridine-dependent deoxygenase	-	-	4.1.3.40,4.1.3.45	ko:K18240	ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110	M00117	R01302,R10597	RC00491,RC02148,RC03212	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_162013_2	472759.Nhal_2765	8.519e-73	252.0	COG0251@1|root,COG0251@2|Bacteria,1NQGP@1224|Proteobacteria,1S2VU@1236|Gammaproteobacteria,1WYNS@135613|Chromatiales	135613|Chromatiales	J	pteridine-dependent deoxygenase	-	-	4.1.3.40,4.1.3.45	ko:K18240	ko00130,ko00400,ko01100,ko01110,map00130,map00400,map01100,map01110	M00117	R01302,R10597	RC00491,RC02148,RC03212	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_162013_3	882083.SacmaDRAFT_4559	1.525e-31	128.0	COG0500@1|root,COG2226@2|Bacteria,2GZW7@201174|Actinobacteria	201174|Actinobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_12
HKD1_k127_1636715_8	987059.RBXJA2T_03853	1.393e-32	139.0	COG2199@1|root,COG2199@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,2WEJC@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K02488	ko02020,ko04112,map02020,map04112	M00511	R08057	-	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	DUF484,GGDEF
HKD1_k127_1636715_1	697282.Mettu_1040	2.501e-197	622.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1XEDH@135618|Methylococcales	135618|Methylococcales	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD1_k127_1636715_0	713586.KB900536_gene341	2.453e-219	685.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RQBM@1236|Gammaproteobacteria,1WWV0@135613|Chromatiales	135613|Chromatiales	E	aminotransferase class I and II	-	-	-	ko:K14261	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1636715_7	1163617.SCD_n01126	3.226e-34	135.0	COG3737@1|root,COG3737@2|Bacteria,1N083@1224|Proteobacteria,2VUF2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF498/DUF598)	-	-	-	-	-	-	-	-	-	-	-	-	DUF498
HKD1_k127_1636715_2	1049564.TevJSym_au00620	1.736e-119	392.0	COG0568@1|root,COG0568@2|Bacteria,1MUDI@1224|Proteobacteria,1RN8V@1236|Gammaproteobacteria,1J4VY@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	COG0568 DNA-directed RNA polymerase, sigma subunit	rpoS	GO:0000988,GO:0000990,GO:0001000,GO:0001121,GO:0001123,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0019899,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043175,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03087	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_1636715_6	1288826.MSNKSG1_04036	3.605e-37	149.0	COG1388@1|root,COG4942@1|root,COG1388@2|Bacteria,COG4942@2|Bacteria,1RD24@1224|Proteobacteria,1RR11@1236|Gammaproteobacteria,466TP@72275|Alteromonadaceae	1236|Gammaproteobacteria	D	COG0739 Membrane proteins related to metalloendopeptidases	nlpD	GO:0000920,GO:0001896,GO:0005575,GO:0005623,GO:0008150,GO:0008219,GO:0009279,GO:0009987,GO:0012501,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0032153,GO:0042221,GO:0042493,GO:0043085,GO:0044093,GO:0044462,GO:0044464,GO:0050790,GO:0050896,GO:0051301,GO:0051336,GO:0051345,GO:0065007,GO:0065009,GO:0071944	-	ko:K06194,ko:K12943	-	-	-	-	ko00000	1.A.34.1.2	-	-	LysM,Peptidase_M23
HKD1_k127_1636715_4	1026882.MAMP_01302	5.977e-73	253.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1RMHZ@1236|Gammaproteobacteria,460E3@72273|Thiotrichales	72273|Thiotrichales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_1636715_3	472759.Nhal_2432	6.264e-118	383.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,1RN36@1236|Gammaproteobacteria,1WW3F@135613|Chromatiales	135613|Chromatiales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD1_k127_1636715_5	105559.Nwat_1707	2.909e-55	198.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,1S6B5@1236|Gammaproteobacteria,1X2FV@135613|Chromatiales	135613|Chromatiales	S	Smr protein	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD1_k127_1637509_5	391615.ABSJ01000017_gene1684	2.435e-140	459.0	COG3385@1|root,COG3385@2|Bacteria,1RM2A@1224|Proteobacteria,1T0RW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase DDE domain group 1	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_4
HKD1_k127_1637509_8	543913.D521_0593	8.97e-22	105.0	2ETRW@1|root,33M9C@2|Bacteria,1NEBE@1224|Proteobacteria,2VXIY@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1637509_4	395494.Galf_0202	2.806e-144	470.0	COG4409@1|root,COG4692@1|root,COG4409@2|Bacteria,COG4692@2|Bacteria,1Q1EG@1224|Proteobacteria,2VMXN@28216|Betaproteobacteria,44VCC@713636|Nitrosomonadales	28216|Betaproteobacteria	G	BNR repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD1_k127_1637509_0	580332.Slit_0317	1.296e-228	730.0	COG1807@1|root,COG1807@2|Bacteria,1R7N1@1224|Proteobacteria,2VPJR@28216|Betaproteobacteria,44V9W@713636|Nitrosomonadales	28216|Betaproteobacteria	M	PFAM glycosyl transferase family 39	-	-	-	-	-	-	-	-	-	-	-	-	PMT
HKD1_k127_1637509_7	580332.Slit_0316	1.421e-40	172.0	COG2246@1|root,COG2246@2|Bacteria,1N92F@1224|Proteobacteria,2VWIE@28216|Betaproteobacteria,44VSF@713636|Nitrosomonadales	28216|Betaproteobacteria	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD1_k127_1637509_3	1485544.JQKP01000011_gene765	5.055e-168	538.0	COG0859@1|root,COG0859@2|Bacteria,1PRP7@1224|Proteobacteria,2VMYH@28216|Betaproteobacteria,44VET@713636|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9
HKD1_k127_1637509_1	243233.MCA0472	2.114e-219	699.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1XDVZ@135618|Methylococcales	135618|Methylococcales	F	PFAM Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_1637509_2	1034943.BN1094_00311	8.4e-180	579.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,1RMA2@1236|Gammaproteobacteria,1JDPJ@118969|Legionellales	118969|Legionellales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_1637509_6	1279038.KB907340_gene1536	1.445e-82	283.0	COG0463@1|root,COG0463@2|Bacteria,1MW2G@1224|Proteobacteria,2TTR9@28211|Alphaproteobacteria,2JQI8@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_1637556_2	323261.Noc_2619	4.811e-90	316.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,1RP5S@1236|Gammaproteobacteria,1WWCN@135613|Chromatiales	135613|Chromatiales	S	Functions as both a chaperone and a metalloprotease. Maintains the integrity of the outer membrane by promoting either the assembly or the elimination of outer membrane proteins, depending on their folding state	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_19
HKD1_k127_1637556_3	340.xcc-b100_1883	7.06e-49	180.0	COG5394@1|root,COG5394@2|Bacteria,1RFY3@1224|Proteobacteria,1S3W3@1236|Gammaproteobacteria,1X66E@135614|Xanthomonadales	135614|Xanthomonadales	S	synthesis repressor, PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD1_k127_1637556_0	95619.PM1_0224770	1.019e-173	552.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Catalyzes the final step of fatty acid oxidation in which acetyl-CoA is released and the CoA ester of a fatty acid two carbons shorter is formed	atoB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_1637556_1	313612.L8106_21834	1.618e-93	317.0	COG0297@1|root,COG0297@2|Bacteria,1G1YU@1117|Cyanobacteria,1H8IV@1150|Oscillatoriales	1117|Cyanobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA2	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_1644544_2	1215092.PA6_011_00250	9.464e-52	187.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,1YCSQ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil	rluC	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_1644544_0	765911.Thivi_3122	3.051e-108	362.0	COG3959@1|root,COG3959@2|Bacteria,1MWRX@1224|Proteobacteria,1RY5K@1236|Gammaproteobacteria,1WVY4@135613|Chromatiales	135613|Chromatiales	G	Transketolase, thiamine diphosphate binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_1644544_1	1336235.JAEG01000010_gene3200	7.802e-71	242.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,2TTU8@28211|Alphaproteobacteria,4BA3D@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_1652589_0	323261.Noc_1718	1.819e-294	914.0	COG0326@1|root,COG0326@2|Bacteria,1MUUE@1224|Proteobacteria,1RNWD@1236|Gammaproteobacteria,1WW6M@135613|Chromatiales	135613|Chromatiales	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
HKD1_k127_1652589_4	472759.Nhal_2283	7.721e-97	323.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,1RP5A@1236|Gammaproteobacteria,1WY1K@135613|Chromatiales	135613|Chromatiales	P	TIGRFAM 3'(2'),5'-bisphosphate nucleotidase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD1_k127_1652589_3	1110502.TMO_0648	1.403e-122	400.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,2JR0D@204441|Rhodospirillales	204441|Rhodospirillales	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1652589_5	118161.KB235922_gene2451	3.045e-07	59.0	2DUHW@1|root,33QRK@2|Bacteria,1GBQ9@1117|Cyanobacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1652589_1	1121033.AUCF01000013_gene1676	4.775e-148	475.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2JPHC@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1652589_2	472759.Nhal_3897	1.045e-123	409.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,1RM8M@1236|Gammaproteobacteria,1WWSQ@135613|Chromatiales	135613|Chromatiales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD1_k127_1657612_5	1165096.ARWF01000001_gene2014	9.388e-61	213.0	COG4149@1|root,COG4149@2|Bacteria,1MUXR@1224|Proteobacteria,2VIZW@28216|Betaproteobacteria,2KKIV@206350|Nitrosomonadales	206350|Nitrosomonadales	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD1_k127_1657612_0	582744.Msip34_2324	8.058e-101	342.0	COG4148@1|root,COG4148@2|Bacteria,1MU8K@1224|Proteobacteria,2VJ3B@28216|Betaproteobacteria,2KNFT@206350|Nitrosomonadales	206350|Nitrosomonadales	P	ABC transporter	-	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran,TOBE
HKD1_k127_1657612_1	472759.Nhal_2098	6.742e-97	321.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,1RMMG@1236|Gammaproteobacteria,1WWBA@135613|Chromatiales	135613|Chromatiales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_1657612_6	697282.Mettu_3881	5.976e-18	90.0	2DIE3@1|root,302Y1@2|Bacteria,1QPR0@1224|Proteobacteria,1SJHJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD1_k127_1657612_2	1304883.KI912532_gene2736	2.118e-83	284.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,2VQTQ@28216|Betaproteobacteria,2KW1F@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_1657612_4	666681.M301_2752	2.373e-69	249.0	COG2353@1|root,COG2353@2|Bacteria,1RJFZ@1224|Proteobacteria,2VQHC@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_1657612_3	666681.M301_2753	3.372e-81	273.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2VS28@28216|Betaproteobacteria,2KKS2@206350|Nitrosomonadales	28216|Betaproteobacteria	C	PFAM cytochrome B561	cybB	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HKD1_k127_1657612_9	656024.FsymDg_1251	8.879e-05	48.0	COG0864@1|root,COG0864@2|Bacteria,2GZCR@201174|Actinobacteria	201174|Actinobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD1_k127_1657612_7	111780.Sta7437_2372	6.439e-15	76.0	COG2337@1|root,COG2337@2|Bacteria,1GM25@1117|Cyanobacteria,3VMWB@52604|Pleurocapsales	1117|Cyanobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_1657612_8	313612.L8106_06409	7.071e-09	57.0	COG4636@1|root,COG4636@2|Bacteria,1G2CH@1117|Cyanobacteria,1H8MY@1150|Oscillatoriales	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_1684246_2	338969.Rfer_3895	1.902e-75	258.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_1684246_0	472759.Nhal_2957	0.0	1188.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,1RQ12@1236|Gammaproteobacteria,1WXC8@135613|Chromatiales	1224|Proteobacteria	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3731,HSP70
HKD1_k127_1684246_1	395019.Bmul_5108	3.863e-292	907.0	COG0443@1|root,COG0443@2|Bacteria,1MXX7@1224|Proteobacteria,2VJ41@28216|Betaproteobacteria,1K1GC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Belongs to the heat shock protein 70 family	-	-	-	-	-	-	-	-	-	-	-	-	HSP70
HKD1_k127_1684246_3	1229205.BUPH_02088	3.206e-55	198.0	2CNUX@1|root,32SHU@2|Bacteria,1REYT@1224|Proteobacteria,2VR2A@28216|Betaproteobacteria,1K2BM@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF2760)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2760
HKD1_k127_1684246_4	396588.Tgr7_2722	8.728e-54	192.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,1S8SE@1236|Gammaproteobacteria,1WYSF@135613|Chromatiales	135613|Chromatiales	P	PFAM ApaG domain protein	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HKD1_k127_1684246_5	1117647.M5M_15520	4.147e-31	124.0	COG0639@1|root,COG0639@2|Bacteria,1MV10@1224|Proteobacteria,1RPUJ@1236|Gammaproteobacteria,1J5RX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP	apaH	GO:0003674,GO:0003824,GO:0004551,GO:0004721,GO:0006139,GO:0006464,GO:0006470,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008138,GO:0008150,GO:0008152,GO:0008796,GO:0008803,GO:0009314,GO:0009628,GO:0009987,GO:0010165,GO:0010212,GO:0015949,GO:0016311,GO:0016462,GO:0016787,GO:0016788,GO:0016791,GO:0016817,GO:0016818,GO:0019538,GO:0034641,GO:0036211,GO:0042578,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044281,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0140096,GO:1901360,GO:1901564	3.6.1.41	ko:K01525	ko00230,map00230	-	R00125	RC00002	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_0052,iEcSMS35_1347.EcSMS35_0053,iJN746.PP_0399,iSDY_1059.SDY_0074	Metallophos
HKD1_k127_1694787_3	765912.Thimo_2205	5.247e-33	132.0	COG0697@1|root,COG0697@2|Bacteria,1RJFE@1224|Proteobacteria,1RZF0@1236|Gammaproteobacteria,1WWYW@135613|Chromatiales	135613|Chromatiales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_1694787_5	1192034.CAP_4297	0.0003547	46.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,42WPJ@68525|delta/epsilon subdivisions,2WR9D@28221|Deltaproteobacteria,2YW59@29|Myxococcales	28221|Deltaproteobacteria	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HKD1_k127_1694787_2	713586.KB900537_gene3235	1.336e-53	204.0	COG1192@1|root,COG1192@2|Bacteria,1MVJU@1224|Proteobacteria,1T16I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	AAA domain	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,MerR
HKD1_k127_1694787_1	383407.XOC_4223	2.899e-64	231.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1X3IJ@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_1694787_0	1123072.AUDH01000003_gene995	6.921e-131	422.0	COG0447@1|root,COG0447@2|Bacteria,1QTZ2@1224|Proteobacteria,2U0ZZ@28211|Alphaproteobacteria,2JW7U@204441|Rhodospirillales	204441|Rhodospirillales	H	Enoyl-CoA hydratase/isomerase	menB	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_1694787_4	1499967.BAYZ01000054_gene4795	5.866e-10	63.0	2E91Y@1|root,333B3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1749527_7	313612.L8106_00720	8.963e-51	186.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G1QI@1117|Cyanobacteria,1H7BP@1150|Oscillatoriales	1117|Cyanobacteria	NU	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
HKD1_k127_1749527_4	1191523.MROS_1651	1.302e-79	275.0	COG0348@1|root,COG0437@1|root,COG0348@2|Bacteria,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	yccM_2	-	-	ko:K02573	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_4,Fer4_5,Fer4_6,Fer4_7,Fer4_8
HKD1_k127_1749527_1	935557.ATYB01000010_gene498	1.616e-107	362.0	COG1641@1|root,COG1641@2|Bacteria,1MUKU@1224|Proteobacteria,2TUW4@28211|Alphaproteobacteria,4BD00@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_1749527_3	426355.Mrad2831_1357	2.074e-84	287.0	COG1606@1|root,COG1606@2|Bacteria,1R7UZ@1224|Proteobacteria,2U5UQ@28211|Alphaproteobacteria,1JSW5@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_1749527_5	935557.ATYB01000010_gene496	2.223e-64	229.0	COG1691@1|root,COG1691@2|Bacteria,1REQ7@1224|Proteobacteria,2U8QR@28211|Alphaproteobacteria,4BF4M@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD1_k127_1749527_6	1049564.TevJSym_af00190	2.281e-60	213.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,1S60Z@1236|Gammaproteobacteria,1J698@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	GO:0002097,GO:0002100,GO:0003674,GO:0003824,GO:0004000,GO:0005488,GO:0006139,GO:0006382,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008251,GO:0008270,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016553,GO:0016787,GO:0016810,GO:0016814,GO:0019239,GO:0034470,GO:0034641,GO:0034660,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0046872,GO:0046914,GO:0052717,GO:0071704,GO:0090304,GO:1901360	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam,dCMP_cyt_deam_1
HKD1_k127_1749527_8	1198232.CYCME_0835	5.839e-37	145.0	COG0824@1|root,COG0824@2|Bacteria,1MZBM@1224|Proteobacteria,1SD0W@1236|Gammaproteobacteria,463F2@72273|Thiotrichales	72273|Thiotrichales	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
HKD1_k127_1749527_2	1173026.Glo7428_0304	2.5e-94	317.0	COG4636@1|root,COG4636@2|Bacteria,1G2CH@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_1749527_0	99598.Cal7507_5420	0.0	1361.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G33Z@1117|Cyanobacteria,1HRQA@1161|Nostocales	1117|Cyanobacteria	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NACHT,NB-ARC,TPR_12,TPR_7,TPR_8
HKD1_k127_1795050_0	187272.Mlg_1037	3.984e-173	557.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_1795050_3	1380394.JADL01000005_gene5450	1.078e-22	102.0	COG0745@1|root,COG0745@2|Bacteria	1380394.JADL01000005_gene5450|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1795050_2	1322246.BN4_11751	3.902e-38	156.0	2FKAD@1|root,34BXX@2|Bacteria,1P2NJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1795050_1	1380391.JIAS01000002_gene3143	1.205e-71	271.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JQ2C@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7,Response_reg
HKD1_k127_1796260_0	56110.Oscil6304_1757	3.541e-98	327.0	COG4636@1|root,COG4636@2|Bacteria,1G2CH@1117|Cyanobacteria,1H8MY@1150|Oscillatoriales	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_1796260_2	357808.RoseRS_1474	4.922e-51	191.0	COG0758@1|root,COG0758@2|Bacteria	2|Bacteria	LU	DNA mediated transformation	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_1796260_1	472759.Nhal_2835	8.951e-55	199.0	COG4636@1|root,COG4636@2|Bacteria,1RJC2@1224|Proteobacteria,1S7B0@1236|Gammaproteobacteria,1WYIQ@135613|Chromatiales	135613|Chromatiales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_1796260_4	357808.RoseRS_1478	2.81e-28	121.0	COG0827@1|root,COG1002@1|root,COG0827@2|Bacteria,COG1002@2|Bacteria,2G84A@200795|Chloroflexi,376BB@32061|Chloroflexia	200795|Chloroflexi	LV	Pfam:Methyltransf_26	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1796260_3	1173020.Cha6605_4047	5.077e-31	123.0	COG3385@1|root,COG5659@1|root,COG3385@2|Bacteria,COG5659@2|Bacteria,1G1TK@1117|Cyanobacteria	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_1812651_7	580332.Slit_2185	7.141e-110	362.0	COG1032@1|root,COG1032@2|Bacteria,1P9J0@1224|Proteobacteria,2VN74@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_1812651_2	157783.LK03_04915	3.401e-186	593.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,1RQX2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Fad linked oxidase	IV02_25675	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1812651_4	234267.Acid_5922	4.867e-178	566.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_1812651_15	1123502.AQXD01000006_gene1796	4.304e-18	91.0	COG3122@1|root,COG3122@2|Bacteria	2|Bacteria	S	Uncharacterized protein conserved in bacteria (DUF2058)	yaiL	-	-	ko:K09912	-	-	-	-	ko00000	-	-	-	DUF2058
HKD1_k127_1812651_13	1163617.SCD_n00985	7.711e-22	105.0	2ED9C@1|root,3375T@2|Bacteria,1NFV2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1812651_11	1499967.BAYZ01000095_gene4055	3.018e-51	186.0	COG0454@1|root,COG0456@2|Bacteria	2|Bacteria	K	acetyltransferase	-	-	2.3.1.82	ko:K18815	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD1_k127_1812651_6	1131553.JIBI01000005_gene2213	7.791e-120	397.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2VJDZ@28216|Betaproteobacteria,37346@32003|Nitrosomonadales	28216|Betaproteobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	1.17.1.1	ko:K12452	ko00520,map00520	-	R03391,R03392	RC00230	ko00000,ko00001,ko01000	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_1812651_8	1499967.BAYZ01000095_gene4057	3.531e-92	315.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlA	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD1_k127_1812651_9	533247.CRD_02274	1.843e-90	310.0	COG1181@1|root,COG1181@2|Bacteria,1G3G5@1117|Cyanobacteria,1HQAK@1161|Nostocales	1117|Cyanobacteria	F	Belongs to the D-alanine--D-alanine ligase family	-	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD1_k127_1812651_3	1121861.KB899916_gene1707	4.086e-180	574.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,2TT31@28211|Alphaproteobacteria,2JPK9@204441|Rhodospirillales	204441|Rhodospirillales	E	lysine 2,3-aminomutase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_1812651_12	1049564.TevJSym_ae00360	5.53e-45	175.0	COG2369@1|root,COG2369@2|Bacteria	2|Bacteria	K	cell adhesion	-	-	-	-	-	-	-	-	-	-	-	-	Phage_Mu_F
HKD1_k127_1812651_1	105559.Nwat_1236	2.205e-239	756.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,1RMNX@1236|Gammaproteobacteria,1WWG0@135613|Chromatiales	135613|Chromatiales	L	Helicase	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
HKD1_k127_1812651_16	1111732.AZOD01000014_gene1510	8.094e-13	77.0	COG0457@1|root,COG0457@2|Bacteria	1111732.AZOD01000014_gene1510|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1812651_0	713586.KB900536_gene635	4.451e-247	786.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,1RNHV@1236|Gammaproteobacteria,1WXN2@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross-linking of the peptide subunits)	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase,UB2H
HKD1_k127_1812651_5	472759.Nhal_0229	2.845e-152	498.0	COG0645@1|root,COG2187@1|root,COG0645@2|Bacteria,COG2187@2|Bacteria,1MU9M@1224|Proteobacteria,1RPG3@1236|Gammaproteobacteria,1WW4S@135613|Chromatiales	135613|Chromatiales	S	AAA domain	-	-	-	ko:K07028	-	-	-	-	ko00000	-	-	-	AAA_33,APH
HKD1_k127_1812651_10	105559.Nwat_2733	8.699e-58	216.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,1WWT6@135613|Chromatiales	135613|Chromatiales	M	Surface antigen variable number	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HKD1_k127_1812651_14	1042375.AFPL01000016_gene37	4.888e-20	95.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,1RNQ3@1236|Gammaproteobacteria,465KK@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG0729 Outer membrane protein	ytfM	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA,POTRA_TamA_1
HKD1_k127_1815136_21	1335757.SPICUR_01445	9.651e-07	52.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_1815136_3	228410.NE2280	2.04e-195	634.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2VGZW@28216|Betaproteobacteria,374K9@32003|Nitrosomonadales	28216|Betaproteobacteria	D	G-rich domain on putative tyrosine kinase	epsB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16692	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_31,CbiA,GNVR,Wzz
HKD1_k127_1815136_8	335283.Neut_2119	3.246e-103	348.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VPSB@28216|Betaproteobacteria,373YG@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_1815136_14	290397.Adeh_4276	1.841e-47	174.0	COG0394@1|root,COG0394@2|Bacteria,1N0DZ@1224|Proteobacteria,42VKF@68525|delta/epsilon subdivisions,2WTAM@28221|Deltaproteobacteria,2Z36N@29|Myxococcales	28221|Deltaproteobacteria	T	Low molecular weight phosphatase family	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_1815136_2	1123400.KB904756_gene2652	1.678e-248	779.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,45ZSE@72273|Thiotrichales	72273|Thiotrichales	C	dihydrolipoamide dehydrogenase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_1815136_10	395493.BegalDRAFT_1318	3.438e-67	235.0	2C8AR@1|root,341QR@2|Bacteria,1NYPB@1224|Proteobacteria,1SQFU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1815136_9	519989.ECTPHS_13492	1.751e-91	304.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,1S2R0@1236|Gammaproteobacteria,1WWXG@135613|Chromatiales	135613|Chromatiales	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD1_k127_1815136_5	713586.KB900536_gene2412	2.534e-154	496.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,1RN23@1236|Gammaproteobacteria,1WWTF@135613|Chromatiales	135613|Chromatiales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
HKD1_k127_1815136_16	396588.Tgr7_0269	1.251e-41	155.0	COG3288@1|root,COG3288@2|Bacteria,1N0TD@1224|Proteobacteria,1SA8D@1236|Gammaproteobacteria,1X1J6@135613|Chromatiales	135613|Chromatiales	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	-	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD1_k127_1815136_4	713587.THITH_01990	1.635e-186	593.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,1RMR4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD1_k127_1815136_12	572477.Alvin_0056	1.606e-59	210.0	COG1490@1|root,COG1490@2|Bacteria,1RGTV@1224|Proteobacteria,1S61I@1236|Gammaproteobacteria,1WYB4@135613|Chromatiales	135613|Chromatiales	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD1_k127_1815136_6	1437882.AZRU01000019_gene6088	8.369e-148	476.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,1RMKF@1236|Gammaproteobacteria,1YE85@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_1815136_15	1283300.ATXB01000001_gene78	6.978e-44	165.0	COG4970@1|root,COG4970@2|Bacteria,1N7RS@1224|Proteobacteria,1SCFB@1236|Gammaproteobacteria,1XFKE@135618|Methylococcales	135618|Methylococcales	NU	Type II transport protein GspH	-	-	-	ko:K08084	-	-	-	-	ko00000,ko02044	3.A.15.2	-	-	GspH,N_methyl
HKD1_k127_1815136_18	1056820.KB900631_gene2318	9.866e-26	113.0	COG4967@1|root,COG4967@2|Bacteria,1N6TG@1224|Proteobacteria,1SC9Z@1236|Gammaproteobacteria,2PP2P@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	NU	type IV pilus modification protein PilV	pilV	-	-	ko:K02671	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl
HKD1_k127_1815136_17	472759.Nhal_0910	3.706e-27	121.0	COG4966@1|root,COG4966@2|Bacteria,1R5YK@1224|Proteobacteria,1RZIZ@1236|Gammaproteobacteria,1WZ5E@135613|Chromatiales	135613|Chromatiales	NU	Type IV Pilus-assembly protein W	-	-	-	ko:K02672	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	N_methyl,PilW
HKD1_k127_1815136_20	472759.Nhal_0909	1.797e-10	69.0	COG4726@1|root,COG4726@2|Bacteria,1N7KP@1224|Proteobacteria,1SCM5@1236|Gammaproteobacteria,1WZD1@135613|Chromatiales	135613|Chromatiales	NU	Type IV pilus assembly protein PilX C-term	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX,PilX_N
HKD1_k127_1815136_1	377629.TERTU_3172	2.438e-252	825.0	COG3419@1|root,COG3419@2|Bacteria,1NUAV@1224|Proteobacteria,1RPV3@1236|Gammaproteobacteria,2PND5@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	NU	Neisseria PilC beta-propeller domain	pilY1	-	-	ko:K02674	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Neisseria_PilC
HKD1_k127_1815136_19	1415754.JQMK01000002_gene2698	1.029e-22	102.0	COG4968@1|root,COG4968@2|Bacteria,1N6QE@1224|Proteobacteria,1SCBS@1236|Gammaproteobacteria,4689X@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG4968 Tfp pilus assembly protein PilE	pilE	-	-	ko:K02655	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	ComP_DUS,N_methyl
HKD1_k127_1815136_7	32042.PstZobell_05533	1.072e-145	466.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,1RMN8@1236|Gammaproteobacteria,1Z0UP@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006090,GO:0006629,GO:0006644,GO:0006720,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0008654,GO:0009058,GO:0009240,GO:0009987,GO:0016491,GO:0019288,GO:0019637,GO:0019682,GO:0019752,GO:0032787,GO:0042380,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046490,GO:0048037,GO:0051536,GO:0051538,GO:0051540,GO:0055114,GO:0071704,GO:0090407,GO:1901135,GO:1901576	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_0030,iECW_1372.ECW_m0028,iEKO11_1354.EKO11_3884,iEcHS_1320.EcHS_A0031,iEcolC_1368.EcolC_3626,iPC815.YPO0477,iSFV_1184.SFV_0023,iSF_1195.SF0026,iSFxv_1172.SFxv_0027,iS_1188.S0028,iWFL_1372.ECW_m0028,iYL1228.KPN_00024	LYTB
HKD1_k127_1815136_11	105559.Nwat_2108	7.551e-61	216.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,1WY9G@135613|Chromatiales	135613|Chromatiales	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD1_k127_1815136_0	395493.BegalDRAFT_3049	0.0	1383.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,1RMTF@1236|Gammaproteobacteria,45ZYC@72273|Thiotrichales	72273|Thiotrichales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD1_k127_1815136_13	631362.Thi970DRAFT_01552	1.623e-50	183.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_1820752_0	105559.Nwat_1590	1.371e-140	455.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,1RMMS@1236|Gammaproteobacteria,1WWRK@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD1_k127_1820752_1	765911.Thivi_1523	9.305e-124	404.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,1RPM1@1236|Gammaproteobacteria,1WW4Q@135613|Chromatiales	135613|Chromatiales	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_1820752_2	545276.KB898730_gene1339	2.454e-64	227.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD1_k127_1820752_6	797303.Natpe_2281	3.129e-25	113.0	COG0415@1|root,arCOG02840@2157|Archaea,2XTVM@28890|Euryarchaeota,23SDQ@183963|Halobacteria	183963|Halobacteria	L	Belongs to the DNA photolyase family	phr1	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD1_k127_1820752_3	765912.Thimo_2436	3.55e-55	194.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,1RNGJ@1236|Gammaproteobacteria,1WXQX@135613|Chromatiales	135613|Chromatiales	L	DNA photolyase	-	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD1_k127_1820752_4	357808.RoseRS_1242	5.762e-35	136.0	28IJG@1|root,2Z8KD@2|Bacteria,2GAQD@200795|Chloroflexi,3771S@32061|Chloroflexia	32061|Chloroflexia	L	XamI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_XamI
HKD1_k127_1820752_7	472759.Nhal_2048	3.607e-13	70.0	COG1724@1|root,COG1724@2|Bacteria,1NB5I@1224|Proteobacteria,1STWS@1236|Gammaproteobacteria,1X1U5@135613|Chromatiales	135613|Chromatiales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_1820752_5	472759.Nhal_2047	1.363e-29	119.0	COG1598@1|root,COG1598@2|Bacteria,1NBUW@1224|Proteobacteria,1SDXU@1236|Gammaproteobacteria,1WZC5@135613|Chromatiales	135613|Chromatiales	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_1846192_6	243233.MCA1944	9.456e-110	361.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1XGYY@135618|Methylococcales	135618|Methylococcales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
HKD1_k127_1846192_7	1284352.AOIG01000028_gene616	1.84e-90	323.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD1_k127_1846192_10	1073999.BN137_3960	9.973e-30	132.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	GO:0003674,GO:0003824,GO:0004595,GO:0005488,GO:0005515,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006732,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015936,GO:0015937,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO0053,iSDY_1059.SDY_4064	CTP_transf_like
HKD1_k127_1846192_2	1283300.ATXB01000001_gene1311	1.807e-177	589.0	COG0457@1|root,COG0457@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1XGD7@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD1_k127_1846192_4	1283300.ATXB01000001_gene1310	1.938e-171	551.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XG1E@135618|Methylococcales	135618|Methylococcales	T	Sigma-54 interaction domain	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1846192_0	1049564.TevJSym_av00270	7.991e-211	677.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,1RQ5N@1236|Gammaproteobacteria,1J539@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	prsK	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c
HKD1_k127_1846192_5	1123393.KB891331_gene2870	1.981e-128	429.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2VIY4@28216|Betaproteobacteria,1KSJS@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD1_k127_1846192_1	1249627.D779_1642	2.18e-201	634.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,1RMX0@1236|Gammaproteobacteria,1WW96@135613|Chromatiales	135613|Chromatiales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	ko:K02474	ko00520,map00520	-	R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_1846192_3	519989.ECTPHS_05295	5.452e-173	546.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,1RPTA@1236|Gammaproteobacteria,1WWHP@135613|Chromatiales	135613|Chromatiales	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_1846192_8	472759.Nhal_3456	6.277e-85	289.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,1RNHQ@1236|Gammaproteobacteria,1WWJC@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD1_k127_1846192_9	1205680.CAKO01000038_gene1458	9.735e-61	212.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,2JS6U@204441|Rhodospirillales	204441|Rhodospirillales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD1_k127_1846192_12	935836.JAEL01000003_gene411	8.033e-08	55.0	COG0346@1|root,COG0346@2|Bacteria,1V9E0@1239|Firmicutes,4HX0J@91061|Bacilli,1ZHMS@1386|Bacillus	91061|Bacilli	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase_2
HKD1_k127_1846192_11	717772.THIAE_06015	1.168e-13	76.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,1RPI3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	COG0790 FOG TPR repeat, SEL1 subfamily	Z012_10315	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD1_k127_186432_1	228410.NE2298	3.073e-63	226.0	COG2267@1|root,COG2267@2|Bacteria,1N2R9@1224|Proteobacteria,2VRME@28216|Betaproteobacteria,372D9@32003|Nitrosomonadales	28216|Betaproteobacteria	I	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_186432_2	522306.CAP2UW1_2763	1.056e-23	106.0	COG5513@1|root,COG5513@2|Bacteria	2|Bacteria	G	serine-type aminopeptidase activity	-	-	-	ko:K02030,ko:K14475	ko05143,map05143	M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	Inhibitor_I42
HKD1_k127_186432_3	545264.KB898750_gene235	1.316e-21	95.0	COG3071@1|root,COG3071@2|Bacteria,1R0UA@1224|Proteobacteria,1T4PM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD1_k127_186432_0	1173022.Cri9333_3813	2.093e-119	395.0	COG3387@1|root,COG3387@2|Bacteria,1G0CW@1117|Cyanobacteria,1H8B4@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Glycosyl hydrolases family 15	-	-	-	ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_15
HKD1_k127_1867446_2	485913.Krac_1388	2.38e-43	162.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_1867446_0	768671.ThimaDRAFT_2842	1.292e-71	246.0	COG3247@1|root,COG3247@2|Bacteria,1RFIH@1224|Proteobacteria,1S6XJ@1236|Gammaproteobacteria,1WYQ5@135613|Chromatiales	135613|Chromatiales	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_1867446_1	1502851.FG93_04310	1.631e-43	177.0	COG2358@1|root,COG2358@2|Bacteria,1Q1N8@1224|Proteobacteria,2V9C0@28211|Alphaproteobacteria,3K4DF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD1_k127_1867446_3	1173024.KI912153_gene171	9.568e-40	151.0	COG3464@1|root,COG3464@2|Bacteria,1G1W2@1117|Cyanobacteria	1117|Cyanobacteria	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,zf-ISL3
HKD1_k127_1867446_4	485913.Krac_10178	2.884e-10	63.0	COG3464@1|root,COG3464@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_23,HTH_7,zf-ISL3
HKD1_k127_1869097_1	396588.Tgr7_0517	5.047e-199	625.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,1RP7U@1236|Gammaproteobacteria,1WX4J@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_1869097_0	765914.ThisiDRAFT_1142	7.469e-237	740.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,1RP7E@1236|Gammaproteobacteria,1WWC9@135613|Chromatiales	135613|Chromatiales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_1869097_4	658612.MD26_02420	7.282e-32	128.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,1S8VY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD1_k127_1869097_2	1260251.SPISAL_07125	2.875e-166	528.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,1RN82@1236|Gammaproteobacteria,1WW91@135613|Chromatiales	135613|Chromatiales	D	TIGRFAM Cell shape determining protein MreB Mrl	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_1869097_3	1249627.D779_0065	6.019e-75	262.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,1RMK4@1236|Gammaproteobacteria,1WWKS@135613|Chromatiales	135613|Chromatiales	M	Involved in formation and maintenance of cell shape	-	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD1_k127_1869097_5	396588.Tgr7_0512	9.525e-18	85.0	COG2891@1|root,COG2891@2|Bacteria,1RER7@1224|Proteobacteria,1S8VI@1236|Gammaproteobacteria,1WYH2@135613|Chromatiales	135613|Chromatiales	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD1_k127_1874902_32	1283300.ATXB01000001_gene879	3.465e-58	228.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1XEBN@135618|Methylococcales	135618|Methylococcales	NU	COG3170 Tfp pilus assembly protein FimV	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_1874902_5	519989.ECTPHS_11110	4.787e-179	564.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,1RNB6@1236|Gammaproteobacteria,1WWMZ@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_1874902_8	519989.ECTPHS_11105	2.353e-164	523.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,1RMZQ@1236|Gammaproteobacteria,1WVY0@135613|Chromatiales	135613|Chromatiales	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_1874902_17	472759.Nhal_1961	5.064e-110	358.0	COG0066@1|root,COG0066@2|Bacteria,1MVXB@1224|Proteobacteria,1RNMK@1236|Gammaproteobacteria,1WW8F@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_1874902_0	396588.Tgr7_1245	1.661e-244	760.0	COG0065@1|root,COG0065@2|Bacteria,1MVYR@1224|Proteobacteria,1RMF6@1236|Gammaproteobacteria,1WWEG@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD1_k127_1874902_22	1049564.TevJSym_ar00190	3.423e-94	317.0	COG0583@1|root,COG0583@2|Bacteria,1NSNV@1224|Proteobacteria,1RPNG@1236|Gammaproteobacteria,1J5PN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	cmpR_1	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_1874902_16	323261.Noc_1881	1.116e-121	405.0	COG2204@1|root,COG2204@2|Bacteria,1NH9G@1224|Proteobacteria,1RRF2@1236|Gammaproteobacteria,1X04Q@135613|Chromatiales	135613|Chromatiales	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat
HKD1_k127_1874902_37	953739.SVEN_7205	2.125e-38	162.0	2CAQZ@1|root,32RRU@2|Bacteria,2ICWM@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_40	47763.JNZA01000002_gene3351	2.447e-31	126.0	2ESDJ@1|root,33JY9@2|Bacteria,2IIMF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_50	1463861.JNXE01000019_gene6102	1.123e-09	62.0	2B5HV@1|root,31YCJ@2|Bacteria,2H0JF@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_42	1214101.BN159_0108	1.184e-23	106.0	2F37X@1|root,33W2D@2|Bacteria,2IN4S@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_53	1214101.BN159_0107	6.874e-08	60.0	2FKGA@1|root,34C3J@2|Bacteria,2IQK4@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_35	1214101.BN159_0106	9.366e-52	203.0	2EB9S@1|root,335AB@2|Bacteria,2ICDP@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_44	1463861.JNXE01000019_gene6097	2.526e-16	86.0	2FDN7@1|root,345PD@2|Bacteria,2IMAU@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_24	47763.JNZA01000002_gene3342	3.624e-88	308.0	COG3299@1|root,COG3299@2|Bacteria,2GMXM@201174|Actinobacteria	201174|Actinobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
HKD1_k127_1874902_33	47763.JNZA01000002_gene3341	7.286e-52	213.0	COG3391@1|root,COG3391@2|Bacteria,2IBT7@201174|Actinobacteria	201174|Actinobacteria	S	Concanavalin A-like lectin/glucanases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3
HKD1_k127_1874902_49	469383.Cwoe_4956	3.708e-12	74.0	2AKFC@1|root,31B6X@2|Bacteria,2GV4J@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_25	1385517.N800_04105	2.879e-87	296.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,1RNGK@1236|Gammaproteobacteria,1X4AP@135614|Xanthomonadales	135614|Xanthomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0016740,GO:0016741,GO:0018364,GO:0019538,GO:0032259,GO:0036009,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0140096,GO:1901564	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD1_k127_1874902_31	519989.ECTPHS_02526	7.299e-60	212.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,1RMT6@1236|Gammaproteobacteria,1WX43@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD1_k127_1874902_27	859657.RPSI07_1123	4.282e-75	256.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2VQC0@28216|Betaproteobacteria,1JZPZ@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD1_k127_1874902_29	1049564.TevJSym_at00730	1.011e-68	236.0	COG0315@1|root,COG0315@2|Bacteria,1RCYZ@1224|Proteobacteria,1S3ST@1236|Gammaproteobacteria,1J5Z2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoaC,ThiS
HKD1_k127_1874902_15	754477.Q7C_897	1.382e-128	421.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,1RPBP@1236|Gammaproteobacteria,4600Z@72273|Thiotrichales	72273|Thiotrichales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD1_k127_1874902_28	156889.Mmc1_1487	4.739e-70	257.0	COG3322@1|root,COG3322@2|Bacteria,1REX0@1224|Proteobacteria,2TWVS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	CHASE4 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_7	330214.NIDE1759	5e-173	560.0	COG0778@1|root,COG0778@2|Bacteria,3J0XZ@40117|Nitrospirae	40117|Nitrospirae	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_4	395493.BegalDRAFT_1621	6.239e-186	593.0	COG0312@1|root,COG0312@2|Bacteria,1NSH6@1224|Proteobacteria,1RR3H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Modulator of DNA gyrase	tldD2	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_1874902_12	395493.BegalDRAFT_1622	3.876e-140	457.0	COG0312@1|root,COG0312@2|Bacteria,1QM7I@1224|Proteobacteria,1RSF3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Zn-dependent	tldE2	-	-	-	-	-	-	-	-	-	-	-	PmbA_TldD
HKD1_k127_1874902_23	1288494.EBAPG3_4670	1.003e-91	307.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2VI2Y@28216|Betaproteobacteria,37245@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_1874902_20	395493.BegalDRAFT_3481	1.912e-102	344.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55)	wbpL	-	-	ko:K13007	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD1_k127_1874902_1	1049564.TevJSym_at00310	1.218e-227	720.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,1RYF4@1236|Gammaproteobacteria,1J8MZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	GM	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_2
HKD1_k127_1874902_10	76114.ebA3792	1.009e-152	493.0	COG1804@1|root,COG1804@2|Bacteria,1MW1H@1224|Proteobacteria,2VJBJ@28216|Betaproteobacteria,2KVC5@206389|Rhodocyclales	206389|Rhodocyclales	C	L-carnitine dehydratase bile acid-inducible protein F	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD1_k127_1874902_30	1279038.KB907343_gene2513	1.144e-65	230.0	2BZNP@1|root,30717@2|Bacteria,1REWN@1224|Proteobacteria,2U7X0@28211|Alphaproteobacteria,2JSDR@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF2889)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2889
HKD1_k127_1874902_48	1165096.ARWF01000001_gene2074	3.169e-12	68.0	COG3313@1|root,COG3313@2|Bacteria,1NGD5@1224|Proteobacteria,2W822@28216|Betaproteobacteria,2KNDD@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Protein of unknown function (DUF1289)	-	-	-	ko:K06938	-	-	-	-	ko00000	-	-	-	DUF1289
HKD1_k127_1874902_2	396588.Tgr7_0903	3.148e-212	666.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,1RNEW@1236|Gammaproteobacteria,1WW9J@135613|Chromatiales	135613|Chromatiales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_1874902_11	713586.KB900536_gene2963	5.959e-146	472.0	COG3705@1|root,COG3705@2|Bacteria,1MWIG@1224|Proteobacteria,1RPRQ@1236|Gammaproteobacteria,1WVUR@135613|Chromatiales	135613|Chromatiales	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD1_k127_1874902_46	1215092.PA6_028_00360	2.414e-14	75.0	COG3242@1|root,COG3242@2|Bacteria,1NG9Q@1224|Proteobacteria,1SH40@1236|Gammaproteobacteria,1YKNI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2065)	yjeT	-	-	ko:K09937	-	-	-	-	ko00000	-	-	-	DUF2065
HKD1_k127_1874902_19	314278.NB231_15483	5.929e-106	351.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,1RM8Z@1236|Gammaproteobacteria,1WW0U@135613|Chromatiales	135613|Chromatiales	O	HflC and HflK could regulate a protease	-	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_1874902_14	1283300.ATXB01000001_gene497	3.06e-129	423.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,1RMUG@1236|Gammaproteobacteria,1XDNN@135618|Methylococcales	135618|Methylococcales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7,HflK_N
HKD1_k127_1874902_9	713586.KB900536_gene2959	7.054e-159	511.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,1RN7V@1236|Gammaproteobacteria,1WVYW@135613|Chromatiales	135613|Chromatiales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_1874902_39	765910.MARPU_07600	6.896e-34	131.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,1WYTY@135613|Chromatiales	135613|Chromatiales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD1_k127_1874902_18	521719.ATXQ01000001_gene577	3.212e-106	353.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,1RMDU@1236|Gammaproteobacteria,1YF30@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	F	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006417,GO:0006725,GO:0006807,GO:0006950,GO:0008033,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009451,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010608,GO:0016070,GO:0016740,GO:0016765,GO:0019222,GO:0031323,GO:0031326,GO:0032268,GO:0033554,GO:0034248,GO:0034470,GO:0034605,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043555,GO:0044237,GO:0044238,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051246,GO:0051716,GO:0052381,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1990497,GO:2000112,GO:2000765	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD1_k127_1874902_21	765912.Thimo_1045	6.814e-102	339.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,1RMZ1@1236|Gammaproteobacteria,1WWA7@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_1874902_34	1049564.TevJSym_ai00820	9.276e-52	190.0	COG3161@1|root,COG3161@2|Bacteria,1N8BF@1224|Proteobacteria,1SDX2@1236|Gammaproteobacteria,1J6IV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway	ubiC	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008813,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016830,GO:0016833,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.1.3.40	ko:K03181	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R01302	RC00491,RC02148	ko00000,ko00001,ko00002,ko01000	-	-	iZ_1308.Z5638	Chor_lyase
HKD1_k127_1874902_13	1049564.TevJSym_ag00220	7.012e-140	455.0	COG4651@1|root,COG4651@2|Bacteria,1QUQS@1224|Proteobacteria,1T21E@1236|Gammaproteobacteria,1J57I@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Kef-type K transport	kefC_1	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_1874902_51	768671.ThimaDRAFT_4402	3.289e-08	55.0	2AI53@1|root,318JB@2|Bacteria,1Q0H7@1224|Proteobacteria,1SUQF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_47	643473.KB235930_gene522	1.532e-13	76.0	2B6KR@1|root,31ZJ6@2|Bacteria,1GF1J@1117|Cyanobacteria,1HTDB@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1874902_36	765911.Thivi_3060	2.363e-43	160.0	2DMVV@1|root,32TZZ@2|Bacteria,1NB2X@1224|Proteobacteria,1SRXS@1236|Gammaproteobacteria,1X1A5@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_1874902_26	323261.Noc_1894	2.505e-78	263.0	COG2442@1|root,COG2442@2|Bacteria,1QW3J@1224|Proteobacteria	1224|Proteobacteria	S	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HKD1_k127_1874902_41	864069.MicloDRAFT_00005320	5.633e-24	107.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_1874902_6	1049564.TevJSym_ac01190	2.394e-174	555.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,1RNHY@1236|Gammaproteobacteria,1J4DE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	GO:0006457,GO:0008150,GO:0009987	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_1874902_3	396588.Tgr7_0972	5.836e-205	643.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales	135613|Chromatiales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_1884343_8	243365.CV_0573	1.68e-23	108.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,2KPED@206351|Neisseriales	206351|Neisseriales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD1_k127_1884343_12	1137271.AZUM01000001_gene1059	0.0002488	47.0	2BRZD@1|root,32KZR@2|Bacteria,2HDNI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1884343_10	926569.ANT_21570	6.524e-10	66.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_1884343_7	1172179.AUKV01000007_gene3094	1.37e-29	125.0	2EABA@1|root,334FH@2|Bacteria,2HY0R@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HKD1_k127_1884343_3	102129.Lepto7375DRAFT_0184	1.306e-121	407.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1H7FN@1150|Oscillatoriales	1117|Cyanobacteria	KLT	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,WD40
HKD1_k127_1884343_1	76114.ebA65	3.79e-177	560.0	COG3177@1|root,COG3177@2|Bacteria,1MWAU@1224|Proteobacteria,2VH5G@28216|Betaproteobacteria,2KXZ2@206389|Rhodocyclales	206389|Rhodocyclales	S	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD1_k127_1884343_2	270374.MELB17_06729	5.857e-144	469.0	COG0661@1|root,COG0661@2|Bacteria,1MW1J@1224|Proteobacteria,1RQYS@1236|Gammaproteobacteria,467UY@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD1_k127_1884343_5	1173028.ANKO01000102_gene5411	6.109e-97	322.0	COG1656@1|root,COG1656@2|Bacteria,1G344@1117|Cyanobacteria,1HAHV@1150|Oscillatoriales	1117|Cyanobacteria	S	Mut7-C ubiquitin	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C,Ub-Mut7C
HKD1_k127_1884343_6	296591.Bpro_4278	1.835e-88	298.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2VQ3B@28216|Betaproteobacteria,4AACE@80864|Comamonadaceae	28216|Betaproteobacteria	O	protein-L-isoaspartate O-methyltransferase	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_1884343_0	1366050.N234_10795	7.926e-286	899.0	COG0421@1|root,COG0421@2|Bacteria,1P220@1224|Proteobacteria,2VNDM@28216|Betaproteobacteria,1KBX2@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Spermine/spermidine synthase domain	-	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HKD1_k127_1884343_9	1122603.ATVI01000006_gene270	1.334e-14	80.0	2E7KC@1|root,3322E@2|Bacteria,1PUQ1@1224|Proteobacteria,1TAQ9@1236|Gammaproteobacteria,1XBP4@135614|Xanthomonadales	135614|Xanthomonadales	S	multidrug transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1884343_11	1333856.L686_16400	3.913e-09	58.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RNJJ@1236|Gammaproteobacteria,1Z14X@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	aapJ	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
HKD1_k127_1908271_11	1207076.ALAT01000168_gene3756	1.413e-16	79.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1Z22G@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_1908271_10	765913.ThidrDRAFT_1724	8.832e-30	123.0	COG0690@1|root,COG0690@2|Bacteria,1RDI9@1224|Proteobacteria,1S3PA@1236|Gammaproteobacteria,1X2GF@135613|Chromatiales	135613|Chromatiales	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	secE	-	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD1_k127_1908271_4	105559.Nwat_2170	3.674e-91	302.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,1RMW0@1236|Gammaproteobacteria,1WWG3@135613|Chromatiales	135613|Chromatiales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD1_k127_1908271_6	1279019.ARQK01000021_gene405	1.974e-70	240.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,1S22R@1236|Gammaproteobacteria,1WXZD@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD1_k127_1908271_2	1042375.AFPL01000058_gene1459	7.315e-109	356.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,1RMDW@1236|Gammaproteobacteria,4649G@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	GO:0000027,GO:0000470,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006417,GO:0006446,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0015934,GO:0016043,GO:0016070,GO:0016072,GO:0017148,GO:0019222,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0032991,GO:0034248,GO:0034249,GO:0034470,GO:0034622,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0045947,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904,GO:2000112,GO:2000113	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD1_k127_1908271_7	396588.Tgr7_2333	1.215e-67	234.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,1S286@1236|Gammaproteobacteria,1WXDE@135613|Chromatiales	135613|Chromatiales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD1_k127_1908271_9	243233.MCA1065	7.408e-46	168.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,1S5V7@1236|Gammaproteobacteria,1XF9Z@135618|Methylococcales	135618|Methylococcales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD1_k127_1908271_0	396588.Tgr7_2331	0.0	2203.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,1RMK0@1236|Gammaproteobacteria,1WX4P@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_1908271_1	472759.Nhal_2379	0.0	2198.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,1RPYH@1236|Gammaproteobacteria,1WVVI@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD1_k127_1908271_5	880073.Calab_2838	3.796e-83	287.0	COG1397@1|root,COG1397@2|Bacteria	2|Bacteria	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_1908271_8	1499967.BAYZ01000139_gene160	1.917e-49	183.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_1908271_3	1123401.JHYQ01000025_gene3304	1.23e-92	312.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,1S22I@1236|Gammaproteobacteria,460KX@72273|Thiotrichales	72273|Thiotrichales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD1_k127_1918896_4	472759.Nhal_3985	8.543e-09	56.0	COG1662@1|root,COG1662@2|Bacteria,1NFF1@1224|Proteobacteria,1SEGH@1236|Gammaproteobacteria,1WZDG@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1
HKD1_k127_1918896_2	313612.L8106_01050	5.004e-20	92.0	COG1413@1|root,COG1413@2|Bacteria,1G4IB@1117|Cyanobacteria,1H9KP@1150|Oscillatoriales	1117|Cyanobacteria	C	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1918896_1	1219077.VAZ01S_016_00040	2.097e-91	307.0	COG3193@1|root,COG3193@2|Bacteria,1R215@1224|Proteobacteria,1S4R1@1236|Gammaproteobacteria,1XZQD@135623|Vibrionales	135623|Vibrionales	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD1_k127_1918896_5	566461.SSFG_05071	0.000215	44.0	COG2189@1|root,COG2189@2|Bacteria	2|Bacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_1918896_0	1040989.AWZU01000011_gene4076	4.834e-171	551.0	COG1520@1|root,COG1520@2|Bacteria,1R95Z@1224|Proteobacteria,2UFTG@28211|Alphaproteobacteria,3K2JC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1918896_3	472759.Nhal_0313	1.26e-16	82.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,1RNID@1236|Gammaproteobacteria,1WX07@135613|Chromatiales	135613|Chromatiales	M	PFAM Cyclopropane-fatty-acyl-phospholipid synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD1_k127_1928337_9	312153.Pnuc_1267	0.000408	43.0	COG4670@1|root,COG4670@2|Bacteria,1MUJW@1224|Proteobacteria,2VH8B@28216|Betaproteobacteria,1K4Y9@119060|Burkholderiaceae	28216|Betaproteobacteria	I	CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons	-	-	2.8.3.1	ko:K01026	ko00620,ko00640,ko00643,ko01100,ko01120,map00620,map00640,map00643,map01100,map01120	-	R00928,R01449,R05508	RC00012,RC00014,RC00137	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_1928337_10	472759.Nhal_1836	0.0004488	47.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1RCFZ@1224|Proteobacteria,1S2QS@1236|Gammaproteobacteria,1X1B9@135613|Chromatiales	135613|Chromatiales	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD1_k127_1928337_3	521098.Aaci_2021	2.545e-58	212.0	COG0500@1|root,COG2226@2|Bacteria,1V7TR@1239|Firmicutes,4HJ1N@91061|Bacilli	91061|Bacilli	Q	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Ubie_methyltran
HKD1_k127_1928337_0	671143.DAMO_0414	2.731e-277	880.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_1928337_7	1173023.KE650771_gene5419	2.113e-12	72.0	2C1A8@1|root,32R8C@2|Bacteria,1G7IA@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1928337_5	357808.RoseRS_0641	6.197e-40	163.0	COG0457@1|root,COG0457@2|Bacteria,2G71Q@200795|Chloroflexi,376GZ@32061|Chloroflexia	32061|Chloroflexia	NU	SMART Tetratricopeptide domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TPR_12,TPR_16,TPR_7
HKD1_k127_1928337_2	768671.ThimaDRAFT_2410	6.626e-60	215.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD1_k127_1928337_4	1235457.C404_11580	1.696e-50	194.0	COG0515@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2VICN@28216|Betaproteobacteria,1K3Q3@119060|Burkholderiaceae	28216|Betaproteobacteria	T	ATP-binding region ATPase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_9,Pkinase
HKD1_k127_1928337_8	697282.Mettu_3687	1.356e-07	58.0	2AYE3@1|root,31QH3@2|Bacteria,1QJ0P@1224|Proteobacteria,1TGY1@1236|Gammaproteobacteria,1XGX4@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2934)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2934
HKD1_k127_1928337_6	641524.ADICYQ_2899	1.05e-31	134.0	2EW6R@1|root,33PJP@2|Bacteria,4P0EV@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1928337_1	338969.Rfer_3895	2.247e-158	511.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_1935517_6	1122604.JONR01000003_gene1486	2.708e-29	120.0	COG0640@1|root,COG0640@2|Bacteria,1MZAU@1224|Proteobacteria,1S8YH@1236|Gammaproteobacteria,1X7HD@135614|Xanthomonadales	135614|Xanthomonadales	K	transcriptional regulators	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20
HKD1_k127_1935517_4	765911.Thivi_1178	2.685e-72	247.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,1S2YD@1236|Gammaproteobacteria,1WY4X@135613|Chromatiales	135613|Chromatiales	T	low molecular weight	-	-	1.20.4.1	ko:K03741,ko:K03892	-	-	-	-	ko00000,ko01000,ko03000	-	-	-	HTH_5,LMWPc
HKD1_k127_1935517_0	1123400.KB904758_gene2205	1.074e-162	518.0	COG0798@1|root,COG0798@2|Bacteria,1MUXY@1224|Proteobacteria,1RP2I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	COG0798 Arsenite efflux pump ACR3 and related permeases	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD1_k127_1935517_5	977880.RALTA_B1893	2.5e-57	203.0	COG0346@1|root,COG0346@2|Bacteria,1RHIV@1224|Proteobacteria,2VTAR@28216|Betaproteobacteria,1K78C@119060|Burkholderiaceae	28216|Betaproteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_1935517_1	667121.ET1_07_00170	7.851e-129	422.0	COG0701@1|root,COG0701@2|Bacteria,1MUN8@1224|Proteobacteria,1RR9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD1_k127_1935517_8	1221522.B723_11265	1.743e-21	96.0	COG0526@1|root,COG0526@2|Bacteria,1N728@1224|Proteobacteria,1SCEC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892,Thioredoxin_3
HKD1_k127_1935517_3	1304878.AUGD01000012_gene4100	8.843e-94	314.0	COG1136@1|root,COG1136@2|Bacteria,1MXVW@1224|Proteobacteria,2U3Z6@28211|Alphaproteobacteria,3K6GU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1935517_2	1304878.AUGD01000012_gene4099	9.547e-122	402.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria,3JVMV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_1935517_7	1532558.JL39_03200	1.66e-25	108.0	COG0845@1|root,COG0845@2|Bacteria,1MV1R@1224|Proteobacteria,2U2MM@28211|Alphaproteobacteria,4BG3B@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_1943779_0	1128421.JAGA01000002_gene1941	7.636e-19	101.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_1984038_3	857087.Metme_3910	7.473e-15	80.0	2EKQ7@1|root,33EDZ@2|Bacteria,1NHK0@1224|Proteobacteria,1SI3D@1236|Gammaproteobacteria,1XFTN@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF2845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2845
HKD1_k127_1984038_4	1500890.JQNL01000001_gene862	0.0005267	51.0	2DR2Y@1|root,339YA@2|Bacteria,1NHB7@1224|Proteobacteria,1SH0X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HKD1_k127_1984038_2	765910.MARPU_11620	8.005e-50	185.0	COG2915@1|root,COG2915@2|Bacteria,1RI8B@1224|Proteobacteria,1RPCC@1236|Gammaproteobacteria,1WXGQ@135613|Chromatiales	135613|Chromatiales	S	High frequency lysogenization protein HflD homolog	hflD	-	-	ko:K07153	-	-	-	-	ko00000	-	-	-	DUF489
HKD1_k127_1984038_1	395493.BegalDRAFT_2327	9.339e-149	478.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,1RMAK@1236|Gammaproteobacteria,45ZSN@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_1984038_0	1121937.AUHJ01000008_gene2028	8.16e-302	942.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,1RNBG@1236|Gammaproteobacteria,465DD@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD1_k127_2005830_1	1266909.AUAG01000034_gene100	1.637e-273	857.0	COG1002@1|root,COG1002@2|Bacteria,1NM9N@1224|Proteobacteria,1RRTM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Type II restriction enzyme, methylase subunits	-	-	-	-	-	-	-	-	-	-	-	-	N6_Mtase
HKD1_k127_2005830_6	870187.Thini_0793	1.095e-33	132.0	2DP6H@1|root,330R7@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0175)	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
HKD1_k127_2005830_12	69014.TK0212	0.0003617	44.0	COG2405@1|root,arCOG00717@2157|Archaea,2Y6DU@28890|Euryarchaeota,2447P@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
HKD1_k127_2005830_0	358220.C380_13925	0.0	1652.0	COG1201@1|root,COG1205@1|root,COG1201@2|Bacteria,COG1205@2|Bacteria,1MVGH@1224|Proteobacteria,2VPE3@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HKD1_k127_2005830_2	156889.Mmc1_1352	1.777e-229	734.0	COG0210@1|root,COG2026@1|root,COG0210@2|Bacteria,COG2026@2|Bacteria,1MWW6@1224|Proteobacteria,2U0T8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD,UvrD-helicase,UvrD_C,UvrD_C_2
HKD1_k127_2005830_3	518766.Rmar_1466	1.862e-150	485.0	COG1304@1|root,COG1304@2|Bacteria,4NEBK@976|Bacteroidetes	976|Bacteroidetes	C	Dehydrogenase	lldD	-	1.1.2.3,1.13.12.4	ko:K00101,ko:K00467	ko00620,ko01100,map00620,map01100	-	R00196,R00319	RC00044,RC01312	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD1_k127_2005830_9	204669.Acid345_4530	3.123e-19	94.0	COG4805@1|root,COG4805@2|Bacteria,3Y4PP@57723|Acidobacteria,2JKV8@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2005830_4	243365.CV_1629	1.429e-81	280.0	COG2113@1|root,COG2113@2|Bacteria,1R5CU@1224|Proteobacteria,2VMGD@28216|Betaproteobacteria	28216|Betaproteobacteria	E	glycine betaine	-	-	-	ko:K02002	ko02010,map02010	M00208	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	OpuAC
HKD1_k127_2005830_10	489825.LYNGBM3L_26080	6.871e-19	88.0	COG3385@1|root,COG3385@2|Bacteria,1G25C@1117|Cyanobacteria,1H83D@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_2005830_8	945550.VISI1226_12406	1.879e-27	113.0	COG1359@1|root,COG1359@2|Bacteria,1NGPW@1224|Proteobacteria,1S8W7@1236|Gammaproteobacteria,1XYKU@135623|Vibrionales	135623|Vibrionales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_2005830_5	1147.D082_26580	5.266e-44	165.0	COG0698@1|root,COG0698@2|Bacteria,1G9WT@1117|Cyanobacteria,1H6QS@1142|Synechocystis	1117|Cyanobacteria	G	Ribose/Galactose Isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_2005830_7	83406.HDN1F_34780	2.086e-31	140.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,1RMI0@1236|Gammaproteobacteria,1J4NA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	U	Type II secretory pathway component ExeA	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22,PG_binding_1
HKD1_k127_2010316_1	768671.ThimaDRAFT_4002	9.861e-169	544.0	COG4196@1|root,COG4196@2|Bacteria,1R6II@1224|Proteobacteria,1SKHQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2126
HKD1_k127_2010316_3	448385.sce6240	8.481e-90	303.0	28KEQ@1|root,2ZA0Y@2|Bacteria,1RBS9@1224|Proteobacteria,439NF@68525|delta/epsilon subdivisions,2X4ZR@28221|Deltaproteobacteria,2YZWJ@29|Myxococcales	28221|Deltaproteobacteria	S	Short C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	SHOCT
HKD1_k127_2010316_7	1538295.JY96_07450	2.651e-59	211.0	COG0280@1|root,COG2030@1|root,COG0280@2|Bacteria,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,2WGKC@28216|Betaproteobacteria,1KJ9Z@119065|unclassified Burkholderiales	28216|Betaproteobacteria	CI	Bifunctional enoyl-CoA hydratase phosphate acetyltransferase	pta	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas,PTA_PTB
HKD1_k127_2010316_13	228410.NE1223	2.044e-13	79.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,2VPG3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_2010316_15	1168065.DOK_17680	1.381e-10	62.0	COG2885@1|root,COG2885@2|Bacteria,1R4WG@1224|Proteobacteria,1RZN8@1236|Gammaproteobacteria,1J93K@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Opacity family porin protein	-	-	-	ko:K03286	-	-	-	-	ko00000,ko02000	1.B.6	-	-	OMP_b-brl,OmpA,TSP_3
HKD1_k127_2010316_8	525897.Dbac_1089	1.804e-31	131.0	2E9FY@1|root,333P7@2|Bacteria,1N8S6@1224|Proteobacteria,42XWP@68525|delta/epsilon subdivisions,2WSIE@28221|Deltaproteobacteria,2MFM6@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2010316_11	497965.Cyan7822_0381	3.04e-17	81.0	2E61I@1|root,330QS@2|Bacteria,1GBDP@1117|Cyanobacteria,3KJU6@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2010316_14	1168059.KB899087_gene2936	2.462e-12	69.0	2DIBA@1|root,302MG@2|Bacteria,1NGIQ@1224|Proteobacteria,2V04D@28211|Alphaproteobacteria,3F05H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Cysteine rich repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_FGFR
HKD1_k127_2010316_12	525897.Dbac_1088	7.364e-16	80.0	2ADPE@1|root,313EG@2|Bacteria,1NEWZ@1224|Proteobacteria,42V0P@68525|delta/epsilon subdivisions,2WSFD@28221|Deltaproteobacteria,2MFC5@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HKD1_k127_2010316_9	690850.Desaf_0974	3.941e-29	122.0	2E8QN@1|root,3331M@2|Bacteria,1ND4I@1224|Proteobacteria,430TR@68525|delta/epsilon subdivisions,2WVZ7@28221|Deltaproteobacteria,2MF52@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2010316_10	1500306.JQLA01000003_gene4503	4.652e-20	96.0	2E560@1|root,32ZYT@2|Bacteria,1RD6P@1224|Proteobacteria,2UJ9J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2010316_5	933262.AXAM01000106_gene2631	6.314e-62	219.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,42R11@68525|delta/epsilon subdivisions,2WMWN@28221|Deltaproteobacteria,2MMZB@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HKD1_k127_2010316_4	1380394.JADL01000013_gene778	3.064e-68	243.0	COG2995@1|root,COG2995@2|Bacteria,1MWG1@1224|Proteobacteria,2TT3D@28211|Alphaproteobacteria,2JS39@204441|Rhodospirillales	204441|Rhodospirillales	S	Paraquat-inducible protein A	-	-	-	ko:K03808	-	-	-	-	ko00000	-	-	-	PqiA
HKD1_k127_2010316_0	243233.MCA0363	1.086e-206	657.0	COG1463@1|root,COG3008@1|root,COG1463@2|Bacteria,COG3008@2|Bacteria,1MU1T@1224|Proteobacteria,1RN89@1236|Gammaproteobacteria,1XEQ8@135618|Methylococcales	135618|Methylococcales	Q	MlaD protein	pqiB	-	-	ko:K06192	-	-	-	-	ko00000	-	-	-	MlaD
HKD1_k127_2010316_6	243233.MCA0364	7.351e-62	222.0	COG3009@1|root,COG3009@2|Bacteria,1N8BW@1224|Proteobacteria,1SHZZ@1236|Gammaproteobacteria,1XF9Y@135618|Methylococcales	135618|Methylococcales	S	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K09857	-	-	-	-	ko00000	-	-	-	ABC_trans_aux
HKD1_k127_2010316_2	768671.ThimaDRAFT_2106	2.881e-150	483.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,1RPDE@1236|Gammaproteobacteria,1WWMT@135613|Chromatiales	135613|Chromatiales	P	PFAM Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD1_k127_2018468_8	1144325.PMI22_03197	1.027e-11	66.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006414,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0019538,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0071944,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_2018468_9	1122164.JHWF01000017_gene503	8.88e-10	60.0	2EG8N@1|root,33A0G@2|Bacteria,1NHU3@1224|Proteobacteria,1SGMX@1236|Gammaproteobacteria,1JGA4@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2018468_4	85643.Tmz1t_1991	9.53e-109	359.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2VH81@28216|Betaproteobacteria,2KVGE@206389|Rhodocyclales	206389|Rhodocyclales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_2018468_5	472759.Nhal_2114	3.668e-72	246.0	29GYT@1|root,303WG@2|Bacteria,1RET9@1224|Proteobacteria,1S6VD@1236|Gammaproteobacteria,1X0VV@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2018468_0	1452718.JBOY01000068_gene1321	8.293e-180	572.0	COG1797@1|root,COG1797@2|Bacteria,1MV7Z@1224|Proteobacteria,1RMCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L-glutamine or ammonia as the nitrogen source	cobB	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_2018468_6	323848.Nmul_A1955	1.827e-40	154.0	COG0226@1|root,COG0226@2|Bacteria,1N19C@1224|Proteobacteria,2VWK2@28216|Betaproteobacteria,3735X@32003|Nitrosomonadales	28216|Betaproteobacteria	P	COG0226 ABC-type phosphate transport system, periplasmic component	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2018468_3	1266925.JHVX01000009_gene141	3.851e-116	387.0	COG3203@1|root,COG3203@2|Bacteria,1PJNW@1224|Proteobacteria,2VJS1@28216|Betaproteobacteria,371M8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_O_P
HKD1_k127_2018468_1	339670.Bamb_3383	8.862e-161	512.0	COG1088@1|root,COG1088@2|Bacteria,1MU5E@1224|Proteobacteria,2VJAD@28216|Betaproteobacteria,1K6B9@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	-	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd,dTDP_sugar_isom
HKD1_k127_2018468_2	339670.Bamb_3386	7.122e-140	449.0	COG1209@1|root,COG1209@2|Bacteria,1MU0X@1224|Proteobacteria,2VHA6@28216|Betaproteobacteria,1K52H@119060|Burkholderiaceae	28216|Betaproteobacteria	M	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis	rfbA	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_2039769_3	215803.DB30_2981	4.601e-17	81.0	COG1335@1|root,COG1335@2|Bacteria,1N48X@1224|Proteobacteria,434GY@68525|delta/epsilon subdivisions,2WYUA@28221|Deltaproteobacteria,2Z0MN@29|Myxococcales	28221|Deltaproteobacteria	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD1_k127_2039769_2	1267534.KB906755_gene4606	1.238e-28	117.0	COG2070@1|root,COG2070@2|Bacteria,3Y37J@57723|Acidobacteria,2JHPQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD1_k127_2039769_1	1267534.KB906755_gene4606	4.049e-38	149.0	COG2070@1|root,COG2070@2|Bacteria,3Y37J@57723|Acidobacteria,2JHPQ@204432|Acidobacteriia	204432|Acidobacteriia	S	Nitronate monooxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD1_k127_2039769_0	420324.KI911994_gene8036	2.234e-80	284.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria	1224|Proteobacteria	L	Resolvase	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_2045398_0	1333856.L686_13735	3.838e-236	751.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1Z1GF@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008728,GO:0008893,GO:0009116,GO:0009117,GO:0009119,GO:0009150,GO:0009259,GO:0009605,GO:0009987,GO:0009991,GO:0015949,GO:0015969,GO:0016020,GO:0016740,GO:0016772,GO:0016778,GO:0016787,GO:0016788,GO:0016794,GO:0019637,GO:0019693,GO:0030312,GO:0031667,GO:0033865,GO:0033875,GO:0034032,GO:0034035,GO:0034641,GO:0042278,GO:0042578,GO:0042594,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046128,GO:0046483,GO:0050896,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:1901068,GO:1901135,GO:1901360,GO:1901564,GO:1901657	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iSFV_1184.SFV_2673	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_2045398_1	497964.CfE428DRAFT_0789	5.881e-44	166.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_2045398_2	472759.Nhal_3013	5.03e-20	104.0	COG1716@1|root,COG1716@2|Bacteria,1R0I1@1224|Proteobacteria,1T4I9@1236|Gammaproteobacteria,1X0YC@135613|Chromatiales	135613|Chromatiales	T	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_2056461_3	1049564.TevJSym_ai00430	5.429e-35	139.0	COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,1S4AS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	KT	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2056461_2	1123502.AQXD01000002_gene243	5.476e-38	150.0	COG2885@1|root,COG2885@2|Bacteria,1RKGT@1224|Proteobacteria,1S6ZQ@1236|Gammaproteobacteria,1X563@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_2056461_0	396588.Tgr7_1531	3.486e-183	582.0	COG0402@1|root,COG0402@2|Bacteria,1MVPA@1224|Proteobacteria,1RN13@1236|Gammaproteobacteria,1WWJ0@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_2056461_1	305900.GV64_13475	2.331e-65	226.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,1XH4S@135619|Oceanospirillales	135619|Oceanospirillales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_23
HKD1_k127_2057101_0	519989.ECTPHS_12803	1.024e-161	514.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WWFM@135613|Chromatiales	135613|Chromatiales	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_2057101_1	1049564.TevJSym_au00100	1.472e-103	343.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria,1J5DH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0840	Hexapep,SATase_N
HKD1_k127_2057101_3	472759.Nhal_1927	6.084e-81	277.0	COG0565@1|root,COG0565@2|Bacteria,1N47Y@1224|Proteobacteria,1RPD3@1236|Gammaproteobacteria,1WVWE@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	2.1.1.200	ko:K02533,ko:K15396	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_2057101_2	1120970.AUBZ01000019_gene3501	1.744e-85	288.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,1RNME@1236|Gammaproteobacteria,464K2@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family	suhB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006020,GO:0006066,GO:0006793,GO:0006796,GO:0007154,GO:0007165,GO:0008150,GO:0008152,GO:0008934,GO:0009056,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019637,GO:0019751,GO:0023052,GO:0031403,GO:0031420,GO:0042578,GO:0043167,GO:0043169,GO:0043647,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046164,GO:0046174,GO:0046434,GO:0046838,GO:0046855,GO:0046872,GO:0047954,GO:0050789,GO:0050794,GO:0050896,GO:0051716,GO:0052745,GO:0052834,GO:0065007,GO:0071545,GO:0071704,GO:1901575,GO:1901615,GO:1901616	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2538,iPC815.YPO2899	Inositol_P
HKD1_k127_2078842_1	1121405.dsmv_1091	8.914e-79	286.0	COG2208@1|root,COG2972@1|root,COG2208@2|Bacteria,COG2972@2|Bacteria,1RCHY@1224|Proteobacteria,42R1G@68525|delta/epsilon subdivisions,2WMR7@28221|Deltaproteobacteria,2MJNU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	protein phosphatase 2C domain protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HAMP,SpoIIE
HKD1_k127_2078842_0	96561.Dole_0793	4.454e-128	417.0	COG1943@1|root,COG1943@2|Bacteria,1MX0E@1224|Proteobacteria,42NN0@68525|delta/epsilon subdivisions,2WM14@28221|Deltaproteobacteria,2MIW7@213118|Desulfobacterales	28221|Deltaproteobacteria	L	SMART Chromosomal replication initiator DnaA domain	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA_C,Y1_Tnp
HKD1_k127_2078842_2	506534.Rhein_3395	2.889e-18	92.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	RHS,RHS_repeat
HKD1_k127_2091321_2	1255043.TVNIR_3448	3.161e-44	172.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_2091321_1	247490.KSU1_B0440	3.364e-45	168.0	2AVTU@1|root,31MME@2|Bacteria,2J2ZG@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2091321_3	870187.Thini_3533	4.78e-05	49.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,1RNTJ@1236|Gammaproteobacteria,462CC@72273|Thiotrichales	72273|Thiotrichales	C	Hydrogenase (NiFe) small subunit HydA	-	-	1.12.5.1	ko:K05927	-	-	-	-	ko00000,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD1_k127_2091321_0	1454004.AW11_01315	4.701e-139	447.0	COG1237@1|root,COG1237@2|Bacteria,1R5S4@1224|Proteobacteria,2VQTV@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	2.5.1.105	ko:K06897	ko00790,map00790	-	R10339	RC00121	ko00000,ko00001,ko01000	-	-	-	-
HKD1_k127_2130726_12	1038859.AXAU01000005_gene5171	9.228e-16	79.0	2E7PS@1|root,3325B@2|Bacteria,1N7R7@1224|Proteobacteria,2UFCM@28211|Alphaproteobacteria,3K0ZR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2130726_6	765911.Thivi_1914	9.677e-90	302.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,1RPRN@1236|Gammaproteobacteria,1WVX9@135613|Chromatiales	135613|Chromatiales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_2130726_11	1499686.BN1079_02476	9.924e-19	91.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,1SD9K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008320,GO:0008565,GO:0009977,GO:0015031,GO:0015291,GO:0015399,GO:0015405,GO:0015450,GO:0015833,GO:0016020,GO:0016021,GO:0022804,GO:0022857,GO:0022884,GO:0031224,GO:0031226,GO:0032991,GO:0033036,GO:0033281,GO:0034613,GO:0042802,GO:0042886,GO:0042887,GO:0043953,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0055085,GO:0065002,GO:0070727,GO:0071702,GO:0071705,GO:0071806,GO:0071944,GO:0098796,GO:0098797,GO:1904680	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_2130726_13	697282.Mettu_1669	1.082e-11	68.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,1XFSS@135618|Methylococcales	135618|Methylococcales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0006886,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0034613,GO:0042886,GO:0045184,GO:0046903,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0070727,GO:0071702,GO:0071705	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_2130726_10	1049564.TevJSym_bh00270	1.009e-41	157.0	COG0140@1|root,COG0140@2|Bacteria,1MZEE@1224|Proteobacteria,1S8R4@1236|Gammaproteobacteria,1J6FV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	phosphoribosyl-ATP pyrophosphohydrolase	hisE	GO:0000105,GO:0003674,GO:0003824,GO:0004636,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.6.1.31	ko:K01523	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-PH
HKD1_k127_2130726_1	400668.Mmwyl1_0751	6.052e-133	426.0	COG0107@1|root,COG0107@2|Bacteria,1MUS0@1224|Proteobacteria,1RPJQ@1236|Gammaproteobacteria,1XIEI@135619|Oceanospirillales	135619|Oceanospirillales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_2130726_3	754477.Q7C_1983	1.777e-119	387.0	COG0106@1|root,COG0106@2|Bacteria,1MW6S@1224|Proteobacteria,1RN3M@1236|Gammaproteobacteria,45ZZE@72273|Thiotrichales	72273|Thiotrichales	E	1-(5-phosphoribosyl)-5- (5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_2130726_7	519989.ECTPHS_01514	6.882e-81	274.0	COG0118@1|root,COG0118@2|Bacteria,1MU4X@1224|Proteobacteria,1RRP3@1236|Gammaproteobacteria,1WWF1@135613|Chromatiales	135613|Chromatiales	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_2130726_5	396588.Tgr7_0213	4.9e-100	328.0	COG0131@1|root,COG0131@2|Bacteria,1MWBS@1224|Proteobacteria,1RPA9@1236|Gammaproteobacteria,1WVVY@135613|Chromatiales	135613|Chromatiales	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD1_k127_2130726_4	713587.THITH_15670	1.596e-104	343.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales	135613|Chromatiales	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD1_k127_2130726_8	472759.Nhal_0133	9.453e-73	250.0	COG4636@1|root,COG4636@2|Bacteria,1RH5Y@1224|Proteobacteria,1S823@1236|Gammaproteobacteria,1WYPU@135613|Chromatiales	135613|Chromatiales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_2130726_2	1469245.JFBG01000080_gene290	4.509e-128	417.0	COG1163@1|root,COG1163@2|Bacteria,1RFPD@1224|Proteobacteria	1224|Proteobacteria	S	TGS domain	-	-	-	ko:K06944	-	-	-	-	ko00000	-	-	-	MMR_HSR1,TGS
HKD1_k127_2130726_0	519989.ECTPHS_02601	1.292e-162	520.0	COG1092@1|root,COG1092@2|Bacteria,1MUGB@1224|Proteobacteria,1RN7Z@1236|Gammaproteobacteria,1WX7X@135613|Chromatiales	135613|Chromatiales	J	SAM-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD1_k127_2130726_9	472759.Nhal_3905	1.574e-55	201.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1WW3W@135613|Chromatiales	135613|Chromatiales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_2132741_0	1040989.AWZU01000015_gene2677	7.048e-65	228.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,2TUG5@28211|Alphaproteobacteria,3JX6C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD1_k127_2132741_5	526226.Gbro_4035	2.631e-07	55.0	COG0607@1|root,COG0607@2|Bacteria,2IN3Q@201174|Actinobacteria,4GE5W@85026|Gordoniaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_2132741_1	261292.Nit79A3_3052	7.566e-63	219.0	COG2193@1|root,COG2193@2|Bacteria,1RF3C@1224|Proteobacteria,2VRIX@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Belongs to the Dps family	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD1_k127_2132741_4	572477.Alvin_1687	3.377e-10	67.0	2E38U@1|root,32Y8I@2|Bacteria,1NENC@1224|Proteobacteria,1SCDF@1236|Gammaproteobacteria,1WZGW@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2132741_2	857087.Metme_0970	1.451e-61	214.0	COG3258@1|root,COG3258@2|Bacteria,1N1U2@1224|Proteobacteria,1SD42@1236|Gammaproteobacteria,1XFNF@135618|Methylococcales	135618|Methylococcales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2132741_3	472759.Nhal_1628	1.009e-39	154.0	COG1662@1|root,COG1662@2|Bacteria,1RICT@1224|Proteobacteria,1T2YD@1236|Gammaproteobacteria,1X23H@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
HKD1_k127_2168831_5	519989.ECTPHS_02726	5.621e-90	301.0	COG0120@1|root,COG0120@2|Bacteria,1MVGR@1224|Proteobacteria,1RNF8@1236|Gammaproteobacteria,1WVVE@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate	rpiA	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD1_k127_2168831_11	864051.BurJ1DRAFT_1133	2.911e-05	49.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2VI5U@28216|Betaproteobacteria,1KIXC@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	GO:0006082,GO:0006520,GO:0006566,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD1_k127_2168831_7	1504672.669783474	4.977e-30	126.0	COG0457@1|root,COG0457@2|Bacteria,1Q84V@1224|Proteobacteria,2VJAQ@28216|Betaproteobacteria,4AB2J@80864|Comamonadaceae	28216|Betaproteobacteria	NU	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,TPR_11,TPR_16,TPR_17,TPR_19,TPR_8
HKD1_k127_2168831_6	243233.MCA0385	4.651e-55	197.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1S5WH@1236|Gammaproteobacteria,1XF9S@135618|Methylococcales	135618|Methylococcales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HKD1_k127_2168831_9	1123392.AQWL01000003_gene514	1.554e-28	123.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2VTZU@28216|Betaproteobacteria,1KSVF@119069|Hydrogenophilales	119069|Hydrogenophilales	J	LigT like Phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	LigT_PEase
HKD1_k127_2168831_4	765912.Thimo_2430	1.047e-174	552.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,1RMHP@1236|Gammaproteobacteria,1WW13@135613|Chromatiales	135613|Chromatiales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD1_k127_2168831_8	477228.YO5_00135	6.554e-29	121.0	COG2137@1|root,COG2137@2|Bacteria,1N6P6@1224|Proteobacteria,1SCMF@1236|Gammaproteobacteria,1Z2US@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Regulatory protein RecX	recX	GO:0003674,GO:0005488,GO:0005515,GO:0006282,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0019219,GO:0019222,GO:0019899,GO:0030234,GO:0031323,GO:0031668,GO:0033554,GO:0043086,GO:0044092,GO:0048583,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0065009,GO:0071496,GO:0080090,GO:0080134,GO:0080135,GO:0098772,GO:2001020	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD1_k127_2168831_1	1249627.D779_0446	0.0	1214.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,1RMWZ@1236|Gammaproteobacteria,1WXPB@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_2168831_2	396588.Tgr7_1290	1.681e-197	622.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,1RN1G@1236|Gammaproteobacteria,1WW7C@135613|Chromatiales	135613|Chromatiales	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_2168831_10	765913.ThidrDRAFT_2612	2.814e-25	107.0	COG1551@1|root,COG1551@2|Bacteria,1N6PG@1224|Proteobacteria,1SCB4@1236|Gammaproteobacteria,1WZ9Q@135613|Chromatiales	135613|Chromatiales	J	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding	csrA	-	-	ko:K03563	ko02020,ko02025,ko02026,ko05111,map02020,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03019	-	-	-	CsrA
HKD1_k127_2168831_12	158500.BV97_02459	0.0008175	45.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales	204457|Sphingomonadales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_2168831_0	765912.Thimo_2289	0.0	1445.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,1RP0K@1236|Gammaproteobacteria,1WVZ3@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III alpha subunit	-	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,Intein_splicing,LAGLIDADG_3,PHP,tRNA_anti-codon
HKD1_k127_2168831_3	75379.Tint_0097	9.005e-182	579.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2VIYB@28216|Betaproteobacteria,1KIY8@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Malic enzyme, NAD binding domain	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malate_DH,Malic_M,PTA_PTB,malic
HKD1_k127_2177975_5	1335757.SPICUR_07275	1.896e-11	66.0	COG1999@1|root,COG1999@2|Bacteria,1RHSV@1224|Proteobacteria,1S6HW@1236|Gammaproteobacteria,1WZ46@135613|Chromatiales	135613|Chromatiales	S	PFAM electron transport protein SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_2177975_4	472759.Nhal_0438	1.124e-92	314.0	COG0688@1|root,COG0688@2|Bacteria,1MVT4@1224|Proteobacteria,1RN1U@1236|Gammaproteobacteria,1WWNF@135613|Chromatiales	135613|Chromatiales	I	Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Prokaryotic type I sub-subfamily	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD1_k127_2177975_1	1249627.D779_1436	1.612e-105	351.0	COG2269@1|root,COG2269@2|Bacteria,1MU97@1224|Proteobacteria,1RMR9@1236|Gammaproteobacteria,1WW5X@135613|Chromatiales	135613|Chromatiales	J	Elongation factor P--(R)-beta-lysine ligase	-	-	-	ko:K04568	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	tRNA-synt_2
HKD1_k127_2177975_3	2340.JV46_03400	9.939e-97	319.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,1RPW7@1236|Gammaproteobacteria,1J4HC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Involved in peptide bond synthesis. Alleviates ribosome stalling that occurs when 3 or more consecutive Pro residues or the sequence PPG is present in a protein, possibly by augmenting the peptidyl transferase activity of the ribosome. Modification of Lys-34 is required for alleviation	efp	GO:0003674,GO:0003676,GO:0003723,GO:0003746,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006414,GO:0006417,GO:0006448,GO:0006518,GO:0006807,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010608,GO:0010629,GO:0017148,GO:0019222,GO:0019538,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032268,GO:0032269,GO:0034248,GO:0034249,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0045900,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051246,GO:0051248,GO:0060255,GO:0065007,GO:0071704,GO:0072344,GO:0080090,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:2000112,GO:2000113,GO:2001124,GO:2001125	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD1_k127_2177975_0	396588.Tgr7_1231	1.679e-120	396.0	COG1509@1|root,COG1509@2|Bacteria,1MUPJ@1224|Proteobacteria,1RM84@1236|Gammaproteobacteria,1WWYX@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	5.4.3.2	ko:K01843,ko:K19810	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000,ko03012	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_2177975_2	105559.Nwat_2727	2.847e-99	349.0	COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1WWNV@135613|Chromatiales	135613|Chromatiales	T	PFAM EAL domain	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
HKD1_k127_2179108_2	1121033.AUCF01000020_gene727	3.526e-37	148.0	COG0600@1|root,COG0600@2|Bacteria,1MWDJ@1224|Proteobacteria,2TRDG@28211|Alphaproteobacteria,2JS5H@204441|Rhodospirillales	204441|Rhodospirillales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_2179108_0	485915.Dret_1645	9.868e-68	240.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,42QRU@68525|delta/epsilon subdivisions,2WMNQ@28221|Deltaproteobacteria,2M95P@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_2179108_5	105559.Nwat_1541	2.233e-23	101.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1X0D0@135613|Chromatiales	135613|Chromatiales	CEH	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_2179108_7	323261.Noc_1583	3.393e-08	57.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1X0D0@135613|Chromatiales	135613|Chromatiales	CEH	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_2179108_6	391612.CY0110_20435	2.529e-18	88.0	COG5428@1|root,COG5428@2|Bacteria,1G9S2@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HKD1_k127_2179108_1	266779.Meso_3839	7.192e-40	150.0	COG4679@1|root,COG4679@2|Bacteria,1MZC9@1224|Proteobacteria,2UKCG@28211|Alphaproteobacteria,43KV0@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HKD1_k127_2179108_3	1297569.MESS2_p200003	2.188e-26	113.0	COG5606@1|root,COG5606@2|Bacteria,1NA3S@1224|Proteobacteria,2UF4K@28211|Alphaproteobacteria,43KY9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HKD1_k127_2179108_4	91464.S7335_267	4.343e-26	108.0	COG1662@1|root,COG3677@1|root,COG1662@2|Bacteria,COG3677@2|Bacteria,1GKEB@1117|Cyanobacteria,1H305@1129|Synechococcus	1117|Cyanobacteria	L	IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1
HKD1_k127_2184394_5	111781.Lepto7376_3804	5.995e-20	102.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,Peptidase_C14,TIR_2
HKD1_k127_2184394_4	448385.sce6213	3.797e-38	152.0	COG1262@1|root,COG1262@2|Bacteria,1NQ5K@1224|Proteobacteria	1224|Proteobacteria	M	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Peptidase_C14
HKD1_k127_2184394_7	1173027.Mic7113_0712	5.492e-09	60.0	COG4636@1|root,COG4636@2|Bacteria,1G2P0@1117|Cyanobacteria,1H6WC@1150|Oscillatoriales	1117|Cyanobacteria	T	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_2184394_2	765914.ThisiDRAFT_2647	1.639e-69	251.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,1RM8H@1236|Gammaproteobacteria,1WWXY@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD1_k127_2184394_1	187272.Mlg_0559	6.935e-70	250.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,1RMN5@1236|Gammaproteobacteria,1WWGT@135613|Chromatiales	135613|Chromatiales	S	Permease YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD1_k127_2184394_0	396588.Tgr7_2140	1.036e-217	685.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,1RNM1@1236|Gammaproteobacteria,1WW8I@135613|Chromatiales	135613|Chromatiales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD1_k127_2184394_3	713586.KB900536_gene971	2.675e-38	147.0	COG2927@1|root,COG2927@2|Bacteria,1MZ3V@1224|Proteobacteria,1S94K@1236|Gammaproteobacteria,1WYQ1@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III, chi subunit	-	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HKD1_k127_2184394_6	187272.Mlg_0514	1.526e-14	77.0	COG3147@1|root,COG3147@2|Bacteria,1N9GW@1224|Proteobacteria,1T2WQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_2201785_0	1048339.KB913029_gene1974	6.559e-237	739.0	COG0017@1|root,COG0017@2|Bacteria,2HFYJ@201174|Actinobacteria,4EWHK@85013|Frankiales	201174|Actinobacteria	J	tRNA synthetases class II (D, K and N)	-	-	6.1.1.23	ko:K09759	ko00970,map00970	M00360	R03647,R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_2201785_12	744980.TRICHSKD4_1567	1.842e-12	76.0	COG0261@1|root,COG3743@1|root,COG0261@2|Bacteria,COG3743@2|Bacteria,1MZEW@1224|Proteobacteria,2UBT3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	HHH_5,Ribosomal_L21p
HKD1_k127_2201785_4	349521.HCH_06472	8.686e-93	319.0	COG2138@1|root,COG2138@2|Bacteria,1QWDT@1224|Proteobacteria,1RZE1@1236|Gammaproteobacteria,1XID5@135619|Oceanospirillales	135619|Oceanospirillales	S	PFAM cobalamin (vitamin B12) biosynthesis CbiX	-	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD1_k127_2201785_6	1207076.ALAT01000099_gene2356	2.84e-71	246.0	COG2082@1|root,COG2082@2|Bacteria,1MX1E@1224|Proteobacteria,1S333@1236|Gammaproteobacteria,1Z459@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Precorrin-8X methylmutase	-	-	-	-	-	-	-	-	-	-	-	-	CbiC
HKD1_k127_2201785_8	570967.JMLV01000001_gene2570	2.779e-63	229.0	COG2243@1|root,COG2243@2|Bacteria,1MV3G@1224|Proteobacteria,2TTJH@28211|Alphaproteobacteria,2JRXN@204441|Rhodospirillales	204441|Rhodospirillales	H	Precorrin-2	cobI	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_2201785_5	1207076.ALAT01000099_gene2359	2.223e-90	306.0	COG2073@1|root,COG2073@2|Bacteria,1MWE6@1224|Proteobacteria,1RPWK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Cobalamin biosynthesis protein CbiG	cbiG	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N,CbiG_mid
HKD1_k127_2201785_3	1207076.ALAT01000099_gene2360	3.006e-102	339.0	COG1010@1|root,COG1010@2|Bacteria,1MU79@1224|Proteobacteria,1RPC2@1236|Gammaproteobacteria,1Z3IZ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	precorrin-3B C17-methyltransferase	cobJ	-	2.1.1.130,2.1.1.131,3.7.1.12	ko:K05934,ko:K13540,ko:K13541	ko00860,ko01100,map00860,map01100	-	R03948,R05180,R05808,R05809,R07772	RC00003,RC01035,RC01293,RC01545,RC01662,RC02097,RC03471	ko00000,ko00001,ko01000	-	-	-	CbiG_N,TP_methylase
HKD1_k127_2201785_9	290512.Paes_1303	2.208e-34	136.0	COG1051@1|root,COG1051@2|Bacteria,1FE2C@1090|Chlorobi	1090|Chlorobi	F	Belongs to the Nudix hydrolase family	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_2201785_2	227377.CBU_0353	5.871e-109	362.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,1RNN9@1236|Gammaproteobacteria,1JD28@118969|Legionellales	118969|Legionellales	OU	Peptidase family S49 N-terminal	sohB	-	-	ko:K04774	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49,Peptidase_S49_N
HKD1_k127_2201785_10	717772.THIAE_08220	1.307e-32	130.0	COG3744@1|root,COG3744@2|Bacteria,1N2T0@1224|Proteobacteria,1S7NW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM PilT protein	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_2201785_11	944435.AXAJ01000016_gene2537	4.013e-19	89.0	COG4118@1|root,COG4118@2|Bacteria,1N7BG@1224|Proteobacteria,2VY0B@28216|Betaproteobacteria,1K9M1@119060|Burkholderiaceae	28216|Betaproteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_2201785_1	720554.Clocl_1256	2.679e-134	437.0	COG1850@1|root,COG1850@2|Bacteria,1TSZQ@1239|Firmicutes,2482N@186801|Clostridia	186801|Clostridia	G	Belongs to the RuBisCO large chain family	-	-	4.1.1.39	ko:K01601	ko00630,ko00710,ko01100,ko01120,ko01200,map00630,map00710,map01100,map01120,map01200	M00165,M00166,M00532	R00024,R03140	RC00172,RC00859	ko00000,ko00001,ko00002,ko01000	-	-	-	RuBisCO_large,RuBisCO_large_N
HKD1_k127_2201785_7	439375.Oant_4834	7.832e-70	241.0	COG3958@1|root,COG3958@2|Bacteria,1N6QF@1224|Proteobacteria,2TTU8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_2203350_0	1183438.GKIL_0100	3.918e-83	280.0	COG1961@1|root,COG1961@2|Bacteria,1G67F@1117|Cyanobacteria	1117|Cyanobacteria	L	DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
HKD1_k127_2203350_1	1395516.PMO01_28535	1.834e-70	243.0	COG2801@1|root,COG2801@2|Bacteria,1QWUR@1224|Proteobacteria,1T3Y1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_2209762_4	1116472.MGMO_72c00100	3.18e-25	109.0	COG3391@1|root,COG3391@2|Bacteria,1R6BZ@1224|Proteobacteria	1224|Proteobacteria	M	phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HKD1_k127_2209762_6	713586.KB900536_gene2139	2.671e-16	78.0	COG0230@1|root,COG0230@2|Bacteria,1NGGS@1224|Proteobacteria,1SGDJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD1_k127_2209762_5	1283300.ATXB01000002_gene2637	2.148e-24	106.0	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria,1XFKR@135618|Methylococcales	135618|Methylococcales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_2209762_3	301.JNHE01000030_gene661	8.19e-31	123.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,1SCG6@1236|Gammaproteobacteria,1YGXT@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009987,GO:0015031,GO:0015833,GO:0016020,GO:0016021,GO:0016043,GO:0031224,GO:0031226,GO:0032977,GO:0033036,GO:0034613,GO:0042886,GO:0044425,GO:0044459,GO:0044464,GO:0045184,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071702,GO:0071705,GO:0071840,GO:0071944,GO:0072657,GO:0090150	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD1_k127_2209762_1	765910.MARPU_16735	3.15e-181	582.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,1RMH1@1236|Gammaproteobacteria,1WWKE@135613|Chromatiales	135613|Chromatiales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD1_k127_2209762_2	1049564.TevJSym_aq00320	4.244e-167	536.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,1RN5S@1236|Gammaproteobacteria,1J4DQ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	GO:0000166,GO:0001510,GO:0001882,GO:0001883,GO:0002097,GO:0002098,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005515,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006457,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009268,GO:0009451,GO:0009628,GO:0009636,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0030488,GO:0030955,GO:0031420,GO:0032259,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0034470,GO:0034641,GO:0034660,GO:0035639,GO:0036094,GO:0042221,GO:0042802,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0061077,GO:0071704,GO:0071944,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD1_k127_2209762_7	880072.Desac_1299	3.458e-11	67.0	2BV05@1|root,32QCR@2|Bacteria,1Q9DV@1224|Proteobacteria,438BY@68525|delta/epsilon subdivisions,2WXNI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2209762_0	697303.Thewi_2171	0.0	1026.0	COG1483@1|root,COG1483@2|Bacteria,1TPPM@1239|Firmicutes,249J3@186801|Clostridia,42FPV@68295|Thermoanaerobacterales	186801|Clostridia	S	Protein of unknown function (DUF499)	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,DUF499,Fn3_assoc
HKD1_k127_2223682_1	1212548.B381_03347	1.125e-80	285.0	COG1538@1|root,COG1538@2|Bacteria,1PCPQ@1224|Proteobacteria,1RRRP@1236|Gammaproteobacteria,1Z0GS@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	MU	COG1538 Outer membrane protein	cebC	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_2223682_0	1288494.EBAPG3_15560	9.339e-157	509.0	COG0845@1|root,COG5569@1|root,COG0845@2|Bacteria,COG5569@2|Bacteria,1MVAS@1224|Proteobacteria,2VJXV@28216|Betaproteobacteria,371P8@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Copper binding periplasmic protein CusF	cusB	-	-	ko:K07798,ko:K15727	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4,8.A.1,8.A.1.2.1	-	-	CusF_Ec,HlyD_D23
HKD1_k127_2228348_3	998674.ATTE01000001_gene735	4.756e-132	428.0	COG0651@1|root,COG0651@2|Bacteria,1MURB@1224|Proteobacteria,1RQBG@1236|Gammaproteobacteria,463IR@72273|Thiotrichales	72273|Thiotrichales	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD1_k127_2228348_1	2340.JV46_13140	1.672e-215	678.0	COG0651@1|root,COG0651@2|Bacteria,1QU5Z@1224|Proteobacteria,1T20X@1236|Gammaproteobacteria,1J4VN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_2228348_5	909663.KI867150_gene1232	6.068e-64	232.0	COG1085@1|root,COG1085@2|Bacteria,1N3RW@1224|Proteobacteria,42NEE@68525|delta/epsilon subdivisions,2WMGC@28221|Deltaproteobacteria,2MRWF@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	galactose-1-phosphate uridylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2228348_8	1123502.AQXD01000004_gene89	3.091e-25	107.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1X8KE@135614|Xanthomonadales	135614|Xanthomonadales	K	COG1278 Cold shock proteins	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_2228348_0	472759.Nhal_1290	0.0	1495.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,1RMU1@1236|Gammaproteobacteria,1WWGW@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM ATP-dependent helicase HrpA	-	-	3.6.4.13	ko:K03578	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,DUF3418,HA2,Helicase_C,OB_NTP_bind
HKD1_k127_2228348_4	870187.Thini_4059	6.911e-83	284.0	COG5464@1|root,COG5464@2|Bacteria,1R8FS@1224|Proteobacteria,1SC36@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_2
HKD1_k127_2228348_2	472759.Nhal_3503	1.625e-142	458.0	COG0451@1|root,COG0451@2|Bacteria,1MVE4@1224|Proteobacteria,1RP2S@1236|Gammaproteobacteria,1X02A@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose	hldD	-	5.1.3.20	ko:K03274	ko00540,ko01100,map00540,map01100	M00064	R05176	RC01291	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase
HKD1_k127_2228348_6	765914.ThisiDRAFT_2065	9.79e-37	139.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,1S8WZ@1236|Gammaproteobacteria,1WZ35@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_2228348_9	870187.Thini_4039	1.46e-10	62.0	COG4260@1|root,COG4260@2|Bacteria,1MXTD@1224|Proteobacteria,1S1VG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SPFH domain-Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,HTH_17,SHOCT
HKD1_k127_2228348_7	1283300.ATXB01000001_gene369	3.481e-33	130.0	COG3853@1|root,COG3853@2|Bacteria,1MZ3B@1224|Proteobacteria,1RZUJ@1236|Gammaproteobacteria,1XE81@135618|Methylococcales	135618|Methylococcales	P	Belongs to the TelA family	-	-	-	-	-	-	-	-	-	-	-	-	TelA
HKD1_k127_2275031_2	1286093.C266_19315	3.564e-43	162.0	COG3946@1|root,COG3946@2|Bacteria,1R7R5@1224|Proteobacteria,2VNFU@28216|Betaproteobacteria,1K2AC@119060|Burkholderiaceae	28216|Betaproteobacteria	U	PFAM virulence factor family protein	-	-	-	-	-	-	-	-	-	-	-	-	VirJ
HKD1_k127_2275031_3	1279017.AQYJ01000029_gene3843	2.385e-11	64.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,464U8@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	COG2366 Protein related to penicillin acylase	quiP	-	3.5.1.11,3.5.1.97	ko:K01434,ko:K07116	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD1_k127_2275031_4	1300345.LF41_1208	3.149e-05	46.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,1RPRP@1236|Gammaproteobacteria,1X56U@135614|Xanthomonadales	135614|Xanthomonadales	S	Penicillin acylase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD1_k127_2275031_0	991905.SL003B_3241	1.122e-240	757.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,4BPQE@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	Acetyl-CoA dehydrogenase C-terminal like	MA20_19860	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD1_k127_2275031_1	502025.Hoch_1977	1.606e-85	291.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,42RV4@68525|delta/epsilon subdivisions,2WP4W@28221|Deltaproteobacteria,2YVNU@29|Myxococcales	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_229543_3	479432.Sros_4287	7.741e-23	101.0	COG1132@1|root,COG1413@1|root,COG1132@2|Bacteria,COG1413@2|Bacteria,2I6NK@201174|Actinobacteria	201174|Actinobacteria	V	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_229543_4	1123355.JHYO01000024_gene1818	4.558e-19	89.0	2EDYZ@1|root,337TS@2|Bacteria,1N7SA@1224|Proteobacteria,2UNBF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_229543_6	697282.Mettu_4368	6.465e-05	48.0	2DP0J@1|root,3301P@2|Bacteria,1N82J@1224|Proteobacteria,1SH0Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	ORF located using Glimmer RBSfinder	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_229543_5	1089553.Tph_c03050	1.145e-05	50.0	COG2452@1|root,COG2452@2|Bacteria,1UF22@1239|Firmicutes,25K2R@186801|Clostridia,42IXF@68295|Thermoanaerobacterales	186801|Clostridia	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_229543_0	1380394.JADL01000006_gene5321	2.573e-184	588.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2JPKJ@204441|Rhodospirillales	204441|Rhodospirillales	C	COG0277 FAD FMN-containing dehydrogenases	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_229543_2	321327.CYA_0587	2.865e-36	142.0	COG2343@1|root,COG2343@2|Bacteria,1G7U6@1117|Cyanobacteria,1H0SQ@1129|Synechococcus	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_9
HKD1_k127_229543_1	472759.Nhal_0500	1.231e-140	452.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_2341139_3	981369.JQMJ01000004_gene4297	7.39e-31	126.0	COG0500@1|root,COG2226@2|Bacteria,2HMMP@201174|Actinobacteria,2NG97@228398|Streptacidiphilus	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_2341139_10	330214.NIDE4363	0.0006191	46.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_2341139_5	105420.BBPO01000003_gene1193	3.629e-22	100.0	COG0500@1|root,COG2226@2|Bacteria,2HMMP@201174|Actinobacteria,2NG97@228398|Streptacidiphilus	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_2341139_0	1207063.P24_10196	5.774e-238	752.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales	204441|Rhodospirillales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD1_k127_2341139_4	472759.Nhal_2115	5.153e-23	105.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_2341139_8	1173023.KE650771_gene5392	2.779e-09	62.0	2EJVP@1|root,33DKD@2|Bacteria,1G92U@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF5132)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5132
HKD1_k127_2341139_6	472759.Nhal_1387	1.035e-16	86.0	2EFY9@1|root,339QE@2|Bacteria,1NM3N@1224|Proteobacteria,1SUUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2341139_7	472759.Nhal_1389	1.963e-13	76.0	COG2608@1|root,COG2608@2|Bacteria,1QY86@1224|Proteobacteria	1224|Proteobacteria	P	mercury ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2341139_1	472759.Nhal_3718	2.798e-140	458.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RND5@1236|Gammaproteobacteria,1WVWX@135613|Chromatiales	135613|Chromatiales	CH	TIGRFAM Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K18800	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04987,R08768	RC00046	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD1_k127_2341139_2	396588.Tgr7_2763	2.065e-82	280.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD1_k127_2379438_0	196367.JNFG01000202_gene2638	3.942e-240	755.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2VGZD@28216|Betaproteobacteria,1K5NT@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Acyl-CoA dehydrogenase N terminal	-	-	-	ko:K20035	ko00920,map00920	-	R11130	RC03363	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD1_k127_2379438_3	335543.Sfum_2395	2.106e-135	434.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,43B4Q@68525|delta/epsilon subdivisions,2X6IC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_2379438_6	335543.Sfum_2395	2.069e-69	237.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,43B4Q@68525|delta/epsilon subdivisions,2X6IC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_2379438_9	456442.Mboo_1435	7.581e-06	49.0	arCOG11028@1|root,arCOG11028@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2379438_1	335543.Sfum_2396	2.493e-155	503.0	COG2239@1|root,COG2239@2|Bacteria,1RFCV@1224|Proteobacteria,42S1B@68525|delta/epsilon subdivisions,2WP0D@28221|Deltaproteobacteria,2MRIR@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	MgtE intracellular N domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
HKD1_k127_2379438_4	1128421.JAGA01000002_gene776	1.164e-87	298.0	COG3342@1|root,COG3342@2|Bacteria,2NP87@2323|unclassified Bacteria	2|Bacteria	S	Family of unknown function (DUF1028)	fimA	-	-	-	-	-	-	-	-	-	-	-	DUF1028,PG_binding_2
HKD1_k127_2379438_5	472759.Nhal_1108	3.3e-81	276.0	COG0500@1|root,COG2226@2|Bacteria,1MVIS@1224|Proteobacteria,1S5K2@1236|Gammaproteobacteria,1X0P5@135613|Chromatiales	135613|Chromatiales	Q	Methyltransferase type 11	-	-	2.1.1.17,2.1.1.71	ko:K00570	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00091	R01320,R02056,R03424	RC00003,RC00060,RC00181,RC00496	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD1_k127_2379438_7	395961.Cyan7425_2202	3.206e-55	198.0	COG3542@1|root,COG3542@2|Bacteria,1G6JR@1117|Cyanobacteria	1117|Cyanobacteria	S	Cupin superfamily (DUF985)	-	-	-	ko:K09705	-	-	-	-	ko00000	-	-	-	Cupin_5
HKD1_k127_2379438_10	1000565.METUNv1_01508	9.26e-05	49.0	2EUZI@1|root,33NER@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2379438_8	864051.BurJ1DRAFT_0148	7.392e-21	95.0	COG2104@1|root,COG2104@2|Bacteria,1N9VX@1224|Proteobacteria,2VVYE@28216|Betaproteobacteria,1KMP9@119065|unclassified Burkholderiales	28216|Betaproteobacteria	H	Mut7-C ubiquitin	-	-	-	-	-	-	-	-	-	-	-	-	ThiS,Ub-Mut7C
HKD1_k127_2379438_2	395493.BegalDRAFT_3410	4.248e-148	478.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,1RN6P@1236|Gammaproteobacteria,461X5@72273|Thiotrichales	72273|Thiotrichales	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_2407927_1	472759.Nhal_0935	1.067e-150	486.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,1X0FN@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_2407927_0	765911.Thivi_2079	1.87e-213	672.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,1RP5K@1236|Gammaproteobacteria,1WW6E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_2407927_2	1120953.AUBH01000011_gene459	3.855e-54	191.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,467D0@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the P(II) protein family	glnK	GO:0003674,GO:0005488,GO:0005515,GO:0006808,GO:0008150,GO:0042802,GO:0045848,GO:0048518,GO:0050789,GO:0065007	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
HKD1_k127_2407927_3	95619.PM1_0202645	2.763e-13	70.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_2436346_13	743299.Acife_0429	0.0002559	46.0	COG2442@1|root,COG2442@2|Bacteria,1N7GJ@1224|Proteobacteria,1T974@1236|Gammaproteobacteria,2NDZF@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_2436346_10	768671.ThimaDRAFT_2728	1.965e-12	71.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,1RY96@1236|Gammaproteobacteria,1WXZ9@135613|Chromatiales	1224|Proteobacteria	KL	DNA RNA helicase	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,SNF2_N
HKD1_k127_2436346_6	713587.THITH_07350	1.832e-73	274.0	28JMK@1|root,2Z9E3@2|Bacteria,1QSC2@1224|Proteobacteria,1S6D6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2868
HKD1_k127_2436346_5	519989.ECTPHS_10456	2.078e-133	440.0	COG1100@1|root,COG1100@2|Bacteria,1R0PX@1224|Proteobacteria,1T4N2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF3482)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3482,MMR_HSR1
HKD1_k127_2436346_3	519989.ECTPHS_08251	2.741e-145	469.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WXIX@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_2436346_4	880073.Calab_3587	1.927e-143	473.0	COG1086@1|root,COG1086@2|Bacteria	2|Bacteria	GM	Polysaccharide biosynthesis protein	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD
HKD1_k127_2436346_1	519989.ECTPHS_07601	4.852e-197	622.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,1RNHP@1236|Gammaproteobacteria,1WW6C@135613|Chromatiales	135613|Chromatiales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_2436346_11	1267005.KB911261_gene2276	1.517e-10	67.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2TSH9@28211|Alphaproteobacteria,3N8D9@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_2436346_8	314278.NB231_06990	1.787e-15	83.0	COG2153@1|root,COG2153@2|Bacteria,1N7TN@1224|Proteobacteria,1SCI6@1236|Gammaproteobacteria,1WYQK@135613|Chromatiales	135613|Chromatiales	S	protein acetylation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2436346_0	396588.Tgr7_1849	1.561e-212	669.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,1RN93@1236|Gammaproteobacteria,1WW57@135613|Chromatiales	135613|Chromatiales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ASL_C,Lyase_1
HKD1_k127_2436346_9	1260251.SPISAL_06790	1.011e-13	80.0	COG4701@1|root,COG4701@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF721)	Y3619	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD1_k127_2436346_2	519989.ECTPHS_09278	1.829e-151	485.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,1RMAT@1236|Gammaproteobacteria,1WXEN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD1_k127_2436346_7	1042375.AFPL01000031_gene817	1.544e-72	250.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,466J6@72275|Alteromonadaceae	1236|Gammaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0003674,GO:0003824,GO:0006082,GO:0006464,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009106,GO:0009107,GO:0009108,GO:0009249,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016053,GO:0016415,GO:0016740,GO:0016746,GO:0016747,GO:0016772,GO:0016779,GO:0016874,GO:0016879,GO:0016979,GO:0018065,GO:0018130,GO:0018193,GO:0018205,GO:0019222,GO:0019538,GO:0019752,GO:0032787,GO:0033819,GO:0036211,GO:0043170,GO:0043412,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044267,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048519,GO:0050789,GO:0051186,GO:0051188,GO:0051604,GO:0060255,GO:0065007,GO:0071704,GO:0072330,GO:0140096,GO:1901360,GO:1901362,GO:1901564,GO:1901576	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	iECSF_1327.ECSF_0569,iSFV_1184.SFV_0696,iSFxv_1172.SFxv_0718	BPL_LplA_LipB
HKD1_k127_2492468_7	1415780.JPOG01000001_gene1355	2.366e-06	53.0	COG1073@1|root,COG1073@2|Bacteria,1PQAX@1224|Proteobacteria,1RZIS@1236|Gammaproteobacteria,1X4J1@135614|Xanthomonadales	135614|Xanthomonadales	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD1_k127_2492468_0	460265.Mnod_7600	3.12e-69	244.0	COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,2TSM7@28211|Alphaproteobacteria,1JRQU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
HKD1_k127_2492468_5	459495.SPLC1_S205710	1.457e-14	74.0	2C1SS@1|root,32YN6@2|Bacteria,1G9HK@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2492468_8	349521.HCH_01378	0.0003688	44.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1XIH1@135619|Oceanospirillales	135619|Oceanospirillales	L	COG1943 Transposase and inactivated derivatives	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_2492468_3	395494.Galf_2325	6.083e-31	125.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,2VKZ3@28216|Betaproteobacteria,44WHN@713636|Nitrosomonadales	28216|Betaproteobacteria	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_2492468_6	1283300.ATXB01000001_gene2102	1.657e-12	79.0	COG1943@1|root,COG1943@2|Bacteria,1P19I@1224|Proteobacteria,1RQYI@1236|Gammaproteobacteria,1XGM7@135618|Methylococcales	135618|Methylococcales	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_2492468_2	1123354.AUDR01000017_gene25	1.255e-32	130.0	2C0JW@1|root,2Z7VX@2|Bacteria,1R695@1224|Proteobacteria,2VZU8@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2492468_1	402777.KB235908_gene132	3.221e-38	151.0	COG0513@1|root,COG0513@2|Bacteria,1G201@1117|Cyanobacteria,1H9BU@1150|Oscillatoriales	1117|Cyanobacteria	JKL	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C
HKD1_k127_2494709_3	1095769.CAHF01000022_gene48	1.554e-91	309.0	COG1295@1|root,COG1295@2|Bacteria,1NH82@1224|Proteobacteria,2VJW7@28216|Betaproteobacteria,472BA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Virulence factor BrkB	-	-	-	-	-	-	-	-	-	-	-	-	Virul_fac_BrkB
HKD1_k127_2494709_5	472759.Nhal_3273	6.058e-37	149.0	COG3103@1|root,COG4991@2|Bacteria,1MX7M@1224|Proteobacteria,1RS74@1236|Gammaproteobacteria,1WY3A@135613|Chromatiales	135613|Chromatiales	T	SH3 domain	-	-	-	ko:K07184	-	-	-	-	ko00000	-	-	-	SH3_3
HKD1_k127_2494709_2	395493.BegalDRAFT_2870	6.295e-95	316.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,1RMJU@1236|Gammaproteobacteria,461ZC@72273|Thiotrichales	72273|Thiotrichales	IQ	KR domain	-	-	1.5.1.33	ko:K03793	-	-	-	-	ko00000,ko01000	-	-	-	adh_short_C2
HKD1_k127_2494709_1	472759.Nhal_0029	3.457e-121	402.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,1RYCJ@1236|Gammaproteobacteria,1WWJG@135613|Chromatiales	135613|Chromatiales	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD1_k127_2494709_4	460265.Mnod_2431	3.808e-83	289.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_2494709_0	1121033.AUCF01000006_gene4073	2.205e-140	450.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,2TSVH@28211|Alphaproteobacteria,2JPVV@204441|Rhodospirillales	204441|Rhodospirillales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
HKD1_k127_2506403_3	159087.Daro_2418	7.775e-143	460.0	COG0438@1|root,COG0438@2|Bacteria,1PVZ8@1224|Proteobacteria,2VPK3@28216|Betaproteobacteria,2KXQZ@206389|Rhodocyclales	206389|Rhodocyclales	M	COG0438 Glycosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2506403_2	159087.Daro_2416	5.265e-167	533.0	COG0438@1|root,COG0438@2|Bacteria,1PKT4@1224|Proteobacteria,2VKJN@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD1_k127_2506403_4	159087.Daro_2414	1.505e-141	465.0	COG2244@1|root,COG2244@2|Bacteria,1R9I0@1224|Proteobacteria,2VQSW@28216|Betaproteobacteria,2KWTM@206389|Rhodocyclales	206389|Rhodocyclales	S	Polysaccharide biosynthesis protein	-	-	-	ko:K03328	-	-	-	-	ko00000	2.A.66.2	-	-	Polysacc_synt_3
HKD1_k127_2506403_5	159087.Daro_2413	5.138e-125	407.0	COG0726@1|root,COG1216@1|root,COG0726@2|Bacteria,COG1216@2|Bacteria,1MVKH@1224|Proteobacteria,2VIWN@28216|Betaproteobacteria,2KVT6@206389|Rhodocyclales	206389|Rhodocyclales	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_2506403_7	765911.Thivi_0634	2.458e-115	394.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,1RMT5@1236|Gammaproteobacteria,1WWAA@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,SurA_N_3
HKD1_k127_2506403_16	1537994.JQFW01000022_gene120	1.106e-08	59.0	2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria,1SGZR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2506403_15	981223.AIED01000149_gene464	9.395e-15	75.0	2EJ6D@1|root,33CXK@2|Bacteria,1NHGW@1224|Proteobacteria,1SGZR@1236|Gammaproteobacteria,3NQBV@468|Moraxellaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2506403_14	626887.J057_19700	1.184e-33	132.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,1S8VH@1236|Gammaproteobacteria,467ZY@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hupB	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_2506403_0	396588.Tgr7_0941	0.0	1190.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1RPCB@1236|Gammaproteobacteria,1WWYF@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_2506403_1	243233.MCA0530	9.599e-220	687.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,1RN9N@1236|Gammaproteobacteria,1XDTP@135618|Methylococcales	135618|Methylococcales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	-	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD1_k127_2506403_9	243233.MCA0529	1.289e-106	349.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,1XE0A@135618|Methylococcales	135618|Methylococcales	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_2506403_8	187272.Mlg_2289	2.272e-107	362.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,1RNZE@1236|Gammaproteobacteria,1WWKF@135613|Chromatiales	135613|Chromatiales	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_2506403_17	1122164.JHWF01000022_gene1733	6.188e-07	53.0	2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2506403_13	118168.MC7420_3010	9.051e-46	171.0	COG0639@1|root,COG0639@2|Bacteria,1GQ13@1117|Cyanobacteria,1HB32@1150|Oscillatoriales	1117|Cyanobacteria	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HKD1_k127_2506403_11	472759.Nhal_1446	6.771e-64	221.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,1TJD2@1236|Gammaproteobacteria,1WYEP@135613|Chromatiales	135613|Chromatiales	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD1_k127_2506403_12	323261.Noc_1699	4.39e-62	228.0	COG2981@1|root,COG2981@2|Bacteria,1MVFT@1224|Proteobacteria,1RMQT@1236|Gammaproteobacteria,1WWYG@135613|Chromatiales	135613|Chromatiales	E	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway	cysZ	-	-	ko:K06203	-	-	-	-	ko00000	-	-	-	DnaJ,EI24
HKD1_k127_2506403_6	502025.Hoch_1849	8.945e-124	406.0	COG1087@1|root,COG1087@2|Bacteria,1R0N8@1224|Proteobacteria,43CYU@68525|delta/epsilon subdivisions,2X870@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD1_k127_2506403_10	1209072.ALBT01000023_gene4042	4.376e-87	293.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1FGIX@10|Cellvibrio	1236|Gammaproteobacteria	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	GO:0003674,GO:0003824,GO:0004652,GO:0004810,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016772,GO:0016779,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0070566,GO:0071704,GO:0090304,GO:1901360,GO:1990817	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_2514189_2	329726.AM1_6084	1.596e-23	102.0	2DNVA@1|root,32ZBE@2|Bacteria,1GFXX@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2514189_0	42256.RradSPS_0358	2.914e-229	730.0	COG2909@1|root,COG2909@2|Bacteria,2HENR@201174|Actinobacteria,4CPC9@84995|Rubrobacteria	84995|Rubrobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K03556	-	-	-	-	ko00000,ko03000	-	-	-	AAA_16,AAA_22,GerE
HKD1_k127_252461_2	1125863.JAFN01000001_gene1064	1.883e-123	402.0	COG0559@1|root,COG0559@2|Bacteria,1N5XH@1224|Proteobacteria,42PN7@68525|delta/epsilon subdivisions,2WIRP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_252461_1	1125863.JAFN01000001_gene1065	3.335e-150	485.0	COG0683@1|root,COG0683@2|Bacteria,1MWQB@1224|Proteobacteria,42PN2@68525|delta/epsilon subdivisions,2WM53@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_252461_0	570952.ATVH01000016_gene2561	0.0	1016.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JPC0@204441|Rhodospirillales	204441|Rhodospirillales	C	malic enzyme	dme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD1_k127_252461_5	768671.ThimaDRAFT_4030	6.451e-37	144.0	COG0071@1|root,COG0071@2|Bacteria,1NA27@1224|Proteobacteria,1S97S@1236|Gammaproteobacteria,1WYZX@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_252461_4	472759.Nhal_1151	1.404e-47	174.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S9S6@1236|Gammaproteobacteria,1WY94@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_252461_3	288000.BBta_7802	5.077e-95	316.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria,3JVXA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_2555729_7	519989.ECTPHS_12403	5.032e-35	138.0	COG5622@1|root,COG5622@2|Bacteria,1N6XP@1224|Proteobacteria,1SCD9@1236|Gammaproteobacteria,1WYG0@135613|Chromatiales	135613|Chromatiales	N	Host attachment protein	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HKD1_k127_2555729_2	373994.Riv7116_0469	5.869e-205	657.0	COG1132@1|root,COG1132@2|Bacteria,1G0C0@1117|Cyanobacteria,1HJ8H@1161|Nostocales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_2555729_3	555779.Dthio_PD1997	1.277e-141	459.0	COG1173@1|root,COG1173@2|Bacteria,1MU26@1224|Proteobacteria,42MFP@68525|delta/epsilon subdivisions,2WJ47@28221|Deltaproteobacteria,2M8HR@213115|Desulfovibrionales	28221|Deltaproteobacteria	EP	PFAM binding-protein-dependent transport systems inner membrane component	oppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD1_k127_2555729_4	794903.OPIT5_07275	2.493e-130	423.0	COG0601@1|root,COG0601@2|Bacteria,46Z95@74201|Verrucomicrobia,3K992@414999|Opitutae	414999|Opitutae	U	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_2555729_1	555779.Dthio_PD1999	2.838e-209	666.0	COG0747@1|root,COG0747@2|Bacteria,1N4PK@1224|Proteobacteria,42P0B@68525|delta/epsilon subdivisions,2X5XH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC-type dipeptide transport system periplasmic component	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_2555729_0	1244869.H261_09487	1.948e-243	766.0	COG4166@1|root,COG4166@2|Bacteria,1MUVU@1224|Proteobacteria,2TQJX@28211|Alphaproteobacteria,2JQ6J@204441|Rhodospirillales	204441|Rhodospirillales	E	COG4166 ABC-type oligopeptide transport system, periplasmic component	-	-	-	ko:K13893	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	SBP_bac_5
HKD1_k127_2555729_5	1283300.ATXB01000001_gene1395	1.461e-117	384.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,1RNMW@1236|Gammaproteobacteria,1XDVR@135618|Methylococcales	135618|Methylococcales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_2555729_6	338963.Pcar_0175	7.94e-117	385.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,43T3R@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_2578238_11	930166.CD58_22380	2.732e-51	193.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478	CobS
HKD1_k127_2578238_9	472759.Nhal_1052	8.48e-70	241.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,1S69R@1236|Gammaproteobacteria,1WXZH@135613|Chromatiales	135613|Chromatiales	G	PFAM Phosphoglycerate mutase	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD1_k127_2578238_7	555778.Hneap_1217	7.359e-100	332.0	COG0483@1|root,COG0483@2|Bacteria,1PPJ0@1224|Proteobacteria,1RMVD@1236|Gammaproteobacteria,1WZZ8@135613|Chromatiales	135613|Chromatiales	G	Inositol monophosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Inositol_P
HKD1_k127_2578238_8	118173.KB235910_gene5103	1.229e-95	319.0	COG0284@1|root,COG0284@2|Bacteria,1G2ED@1117|Cyanobacteria,1HFSI@1150|Oscillatoriales	1117|Cyanobacteria	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD1_k127_2578238_2	572477.Alvin_2085	1.372e-161	518.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,1RPEY@1236|Gammaproteobacteria,1WWZH@135613|Chromatiales	135613|Chromatiales	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_2578238_1	870187.Thini_0173	2.622e-176	557.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,1RMKU@1236|Gammaproteobacteria,45ZSU@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_2578238_4	671143.DAMO_0892	1.077e-151	484.0	COG4870@1|root,COG4870@2|Bacteria	2|Bacteria	O	transferase activity, transferring glycosyl groups	-	-	3.4.22.38	ko:K01371	ko04142,ko04210,ko04380,ko04620,ko05323,map04142,map04210,map04380,map04620,map05323	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_C1
HKD1_k127_2578238_3	1121405.dsmv_0171	4.655e-158	518.0	COG0507@1|root,COG0507@2|Bacteria,1MW43@1224|Proteobacteria,42NRK@68525|delta/epsilon subdivisions,2WIM6@28221|Deltaproteobacteria,2MI96@213118|Desulfobacterales	28221|Deltaproteobacteria	L	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD	recD	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,UvrD_C_2
HKD1_k127_2578238_18	697282.Mettu_3881	2.943e-06	53.0	2DIE3@1|root,302Y1@2|Bacteria,1QPR0@1224|Proteobacteria,1SJHJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD1_k127_2578238_17	90814.KL370891_gene447	1.918e-07	55.0	2DRGH@1|root,33BMH@2|Bacteria,1NPG2@1224|Proteobacteria,1SHUG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD1_k127_2578238_13	179408.Osc7112_1713	5.346e-40	152.0	2C9PJ@1|root,32RPM@2|Bacteria,1G7Z4@1117|Cyanobacteria,1HCGH@1150|Oscillatoriales	1117|Cyanobacteria	S	XisI protein	-	-	-	-	-	-	-	-	-	-	-	-	XisI
HKD1_k127_2578238_10	1173027.Mic7113_3552	4.041e-53	190.0	296N4@1|root,31F23@2|Bacteria,1G6IE@1117|Cyanobacteria,1HBQF@1150|Oscillatoriales	1117|Cyanobacteria	S	XisH protein	-	-	-	-	-	-	-	-	-	-	-	-	XisH
HKD1_k127_2578238_19	1173264.KI913949_gene1102	1.716e-05	49.0	29CI8@1|root,2ZZGQ@2|Bacteria,1G5V0@1117|Cyanobacteria,1HB9E@1150|Oscillatoriales	1117|Cyanobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD1_k127_2578238_16	313612.L8106_20198	6.779e-12	67.0	COG3677@1|root,COG3677@2|Bacteria,1G876@1117|Cyanobacteria,1HDAC@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Zn_Tnp_IS1
HKD1_k127_2578238_5	1163617.SCD_n00346	1.133e-109	362.0	COG1575@1|root,COG1575@2|Bacteria,1MXQQ@1224|Proteobacteria,2VJX1@28216|Betaproteobacteria	28216|Betaproteobacteria	H	Belongs to the MenA family. Type 1 subfamily	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_2578238_6	1122604.JONR01000034_gene407	8.19e-106	348.0	COG1024@1|root,COG1024@2|Bacteria,1R3Q4@1224|Proteobacteria,1RQ45@1236|Gammaproteobacteria,1X9D6@135614|Xanthomonadales	135614|Xanthomonadales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_2578238_14	1283300.ATXB01000001_gene1949	1.065e-39	152.0	COG1734@1|root,COG1734@2|Bacteria,1NH80@1224|Proteobacteria,1SAW8@1236|Gammaproteobacteria,1XGQM@135618|Methylococcales	135618|Methylococcales	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD1_k127_2578238_12	478741.JAFS01000002_gene788	3.256e-45	168.0	COG1371@1|root,COG1371@2|Bacteria,46YT2@74201|Verrucomicrobia,37GUG@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD1_k127_2578238_0	472759.Nhal_1884	6.573e-186	589.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,1RMXH@1236|Gammaproteobacteria,1WZYK@135613|Chromatiales	135613|Chromatiales	H	Belongs to the RtcB family	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD1_k127_2595842_3	886293.Sinac_0730	0.000961	52.0	COG1858@1|root,COG3391@1|root,COG1858@2|Bacteria,COG3391@2|Bacteria,2IYMJ@203682|Planctomycetes	203682|Planctomycetes	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG,Cytochrom_C
HKD1_k127_2595842_0	1095769.CAHF01000014_gene2964	1.332e-190	613.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2VI60@28216|Betaproteobacteria,473N1@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_2595842_2	641491.DND132_0095	3.676e-145	473.0	COG0174@1|root,COG0174@2|Bacteria,1MU6V@1224|Proteobacteria,43A4D@68525|delta/epsilon subdivisions,2X1W9@28221|Deltaproteobacteria,2M9SN@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD1_k127_2595842_1	1173028.ANKO01000174_gene2669	2.299e-157	503.0	COG2159@1|root,COG2159@2|Bacteria,1G2HJ@1117|Cyanobacteria,1H9XN@1150|Oscillatoriales	1117|Cyanobacteria	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_2642218_3	396588.Tgr7_2239	9.647e-45	166.0	COG0494@1|root,COG0494@2|Bacteria,1RH6N@1224|Proteobacteria,1S20Q@1236|Gammaproteobacteria,1WY8G@135613|Chromatiales	135613|Chromatiales	L	pfam nudix	-	-	3.6.1.67	ko:K08310	ko00790,map00790	M00126	R04638	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HKD1_k127_2642218_0	396588.Tgr7_2240	4.52e-285	888.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,1RNMI@1236|Gammaproteobacteria,1WXVV@135613|Chromatiales	135613|Chromatiales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_2642218_5	1249627.D779_3318	2.136e-32	130.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,1SCJS@1236|Gammaproteobacteria,1WYXS@135613|Chromatiales	135613|Chromatiales	S	Regulatory protein, FmdB family	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_2642218_4	251229.Chro_1448	3.35e-39	150.0	COG3577@1|root,COG3577@2|Bacteria,1G657@1117|Cyanobacteria	1117|Cyanobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
HKD1_k127_2642218_1	396588.Tgr7_3262	2.409e-227	712.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1WW4B@135613|Chromatiales	135613|Chromatiales	T	response regulator	glnG	-	-	ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_2642218_2	519989.ECTPHS_01379	2.548e-122	402.0	COG3852@1|root,COG3852@2|Bacteria,1MVN6@1224|Proteobacteria,1RN15@1236|Gammaproteobacteria,1WWFQ@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	2.7.13.3	ko:K07708	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS,PAS_4
HKD1_k127_2667606_2	1121033.AUCF01000002_gene574	4.368e-100	331.0	COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,2TRJA@28211|Alphaproteobacteria,2JRRS@204441|Rhodospirillales	204441|Rhodospirillales	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02074	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
HKD1_k127_2667606_1	1380394.JADL01000011_gene4011	3.12e-113	372.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,2JQRW@204441|Rhodospirillales	204441|Rhodospirillales	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HKD1_k127_2667606_3	941449.dsx2_1641	3.482e-95	321.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2M807@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_2667606_9	195250.CM001776_gene3671	1.263e-29	129.0	COG4531@1|root,COG4531@2|Bacteria	2|Bacteria	P	zinc ion transport	lraI	-	1.6.5.3,4.99.1.12	ko:K00341,ko:K02077,ko:K09121,ko:K09796	ko00190,ko01100,map00190,map01100	M00144,M00244	R11945	RC00061	ko00000,ko00001,ko00002,ko01000,ko02000,ko03110	3.A.1.15,3.D.1	-	-	DUF2796
HKD1_k127_2667606_5	2340.JV46_08550	3.985e-85	288.0	COG1136@1|root,COG1136@2|Bacteria,1RA1K@1224|Proteobacteria,1S275@1236|Gammaproteobacteria,1J63T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2667606_0	765912.Thimo_2506	2.329e-185	587.0	COG0577@1|root,COG0577@2|Bacteria,1MVN1@1224|Proteobacteria,1RNVN@1236|Gammaproteobacteria,1WXQU@135613|Chromatiales	135613|Chromatiales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2667606_8	1348657.M622_07365	4.956e-42	163.0	COG3495@1|root,COG3495@2|Bacteria,1RB8H@1224|Proteobacteria,2VSUS@28216|Betaproteobacteria,2KYV8@206389|Rhodocyclales	206389|Rhodocyclales	S	protein conserved in bacteria	-	-	-	ko:K09950	-	-	-	-	ko00000	-	-	-	DUF3299
HKD1_k127_2667606_4	1040989.AWZU01000008_gene3656	1.398e-94	337.0	COG0330@1|root,COG0701@1|root,COG0330@2|Bacteria,COG0701@2|Bacteria	2|Bacteria	S	Predicted permease	-	-	3.6.3.54	ko:K07089,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	ArsP_1,Band_7,HMA
HKD1_k127_2667606_6	158190.SpiGrapes_2806	1.163e-65	236.0	COG0330@1|root,COG0330@2|Bacteria,2J5TU@203691|Spirochaetes	2|Bacteria	O	HflC and HflK could regulate a protease	hflC2	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_2667606_7	665942.HMPREF1022_03128	2.268e-49	188.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,42NUT@68525|delta/epsilon subdivisions,2WKQX@28221|Deltaproteobacteria,2M80N@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_2667606_10	373994.Riv7116_5052	2.248e-08	56.0	COG1609@1|root,COG1609@2|Bacteria,1G54D@1117|Cyanobacteria,1HMP3@1161|Nostocales	1117|Cyanobacteria	K	PFAM Rhodopirellula transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_2675132_2	1335757.SPICUR_00365	6.218e-36	141.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,1RME0@1236|Gammaproteobacteria,1WXGA@135613|Chromatiales	135613|Chromatiales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_2675132_0	1335757.SPICUR_00360	0.0	1240.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,1RN8K@1236|Gammaproteobacteria,1WWM2@135613|Chromatiales	135613|Chromatiales	C	Dehydrogenase E1 component	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD1_k127_2675132_1	717231.Flexsi_0763	2.958e-57	200.0	COG0174@1|root,COG0174@2|Bacteria,2GF6Q@200930|Deferribacteres	200930|Deferribacteres	E	Glutamine synthetase, catalytic domain	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_2740426_12	314278.NB231_12299	5.577e-08	54.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_2740426_14	1433126.BN938_2445	3.869e-06	56.0	293J4@1|root,2ZR15@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2740426_11	765912.Thimo_2710	4.212e-14	76.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,1RNCD@1236|Gammaproteobacteria,1WXTN@135613|Chromatiales	135613|Chromatiales	E	Aminotransferase class-V	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_2740426_8	555779.Dthio_PD0435	2.882e-22	101.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_2740426_2	395494.Galf_0934	4.495e-114	379.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	metabolite transporter	cnrT	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_2740426_10	391735.Veis_2831	2.55e-15	79.0	COG0789@1|root,COG0789@2|Bacteria,1MZ3P@1224|Proteobacteria,2VUJS@28216|Betaproteobacteria,4AE22@80864|Comamonadaceae	28216|Betaproteobacteria	K	Cd(II) Pb(II)-responsive transcriptional regulator	cadR	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind,MerR_1
HKD1_k127_2740426_3	243233.MCA2619	3.802e-86	313.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1S4UJ@1236|Gammaproteobacteria,1XEKD@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K01286	-	-	-	-	ko00000,ko01000	-	-	-	Peptidase_S11
HKD1_k127_2740426_5	95619.PM1_0200840	1.232e-75	261.0	COG2099@1|root,COG2099@2|Bacteria,1MW48@1224|Proteobacteria,1S0P4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	reductase	cobK	-	1.3.1.106,1.3.1.54	ko:K05895	ko00860,ko01100,map00860,map01100	-	R05150,R05812	RC01280	ko00000,ko00001,ko01000	-	-	-	CbiJ
HKD1_k127_2740426_1	1192124.LIG30_0457	5.748e-146	470.0	COG1903@1|root,COG1903@2|Bacteria,1MXU3@1224|Proteobacteria,2VITG@28216|Betaproteobacteria,1K0BP@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
HKD1_k127_2740426_7	1380394.JADL01000005_gene5490	2.256e-34	137.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,2JSA6@204441|Rhodospirillales	204441|Rhodospirillales	I	COG2867 Oligoketide cyclase lipid transport protein	-	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
HKD1_k127_2740426_4	631454.N177_1930	3.016e-85	290.0	COG1126@1|root,COG1126@2|Bacteria,1MWKQ@1224|Proteobacteria,2TSCU@28211|Alphaproteobacteria,1JQ5M@119043|Rhodobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
HKD1_k127_2740426_6	713586.KB900536_gene639	1.013e-47	175.0	COG0585@1|root,COG0585@2|Bacteria,1MXHD@1224|Proteobacteria,1RPRF@1236|Gammaproteobacteria,1WWFE@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs	truD	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
HKD1_k127_2740426_0	870187.Thini_0110	2.742e-179	578.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,4607H@72273|Thiotrichales	72273|Thiotrichales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_2740426_13	84531.JMTZ01000056_gene2534	1.612e-06	50.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,1RNGQ@1236|Gammaproteobacteria,1X482@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD1_k127_2742123_0	765911.Thivi_4566	1.376e-184	586.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria,1X2E1@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD1_k127_2742123_1	1096546.WYO_1835	6.958e-14	71.0	COG1878@1|root,COG1878@2|Bacteria,1MWWB@1224|Proteobacteria,2TSIG@28211|Alphaproteobacteria,1JT9Y@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase,TAT_signal
HKD1_k127_2756822_0	1266925.JHVX01000007_gene2379	6.936e-139	448.0	COG1657@1|root,COG1657@2|Bacteria,1MUIP@1224|Proteobacteria,2VPI8@28216|Betaproteobacteria,372CD@32003|Nitrosomonadales	28216|Betaproteobacteria	I	PFAM Prenyltransferase squalene oxidase	shc	-	4.2.1.129,5.4.99.17	ko:K06045	ko00909,ko01110,map00909,map01110	-	R07322,R07323	RC01850,RC01851	ko00000,ko00001,ko01000	-	-	-	SQHop_cyclase_C,SQHop_cyclase_N
HKD1_k127_2756822_1	472759.Nhal_1310	4.518e-128	418.0	COG1562@1|root,COG1562@2|Bacteria,1R4ZD@1224|Proteobacteria,1RS93@1236|Gammaproteobacteria,1X0KC@135613|Chromatiales	135613|Chromatiales	I	Squalene phytoene synthase	-	-	2.5.1.21	ko:K00801	ko00100,ko00909,ko01100,ko01110,ko01130,map00100,map00909,map01100,map01110,map01130	-	R00702,R02872,R06223	RC00362,RC00796,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	SQS_PSY
HKD1_k127_2756822_3	472759.Nhal_1238	3.401e-124	409.0	COG1215@1|root,COG1215@2|Bacteria,1MW1E@1224|Proteobacteria,1RZY2@1236|Gammaproteobacteria,1X091@135613|Chromatiales	135613|Chromatiales	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_2756822_2	105559.Nwat_1371	1.768e-124	402.0	COG0535@1|root,COG0535@2|Bacteria,1MXM1@1224|Proteobacteria,1RNQ1@1236|Gammaproteobacteria,1X06Z@135613|Chromatiales	135613|Chromatiales	S	Radical SAM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3463,Radical_SAM
HKD1_k127_2788237_4	631362.Thi970DRAFT_03324	2.116e-06	59.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1WW9X@135613|Chromatiales	135613|Chromatiales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD1_k127_2788237_0	243233.MCA0105	3.124e-128	421.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,1RMJA@1236|Gammaproteobacteria,1XE3C@135618|Methylococcales	135618|Methylococcales	M	Belongs to the peptidase S11 family	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_2788237_1	396588.Tgr7_2706	2.284e-95	320.0	COG0115@1|root,COG0115@2|Bacteria,1MVAT@1224|Proteobacteria,1RPU0@1236|Gammaproteobacteria,1WX40@135613|Chromatiales	135613|Chromatiales	EH	PFAM Aminotransferase, class IV	-	-	2.6.1.21	ko:K00824	ko00310,ko00330,ko00360,ko00472,ko00473,ko01100,map00310,map00330,map00360,map00472,map00473,map01100	-	R01148,R01582,R02459,R02851,R02924,R05053	RC00006,RC00008,RC00025	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_2788237_2	1116472.MGMO_86c00240	6.799e-21	94.0	COG2921@1|root,COG2921@2|Bacteria,1PJDX@1224|Proteobacteria,1THTC@1236|Gammaproteobacteria,1XFN8@135618|Methylococcales	135618|Methylococcales	S	Belongs to the UPF0250 family	-	-	-	ko:K09158	-	-	-	-	ko00000	-	-	-	DUF493
HKD1_k127_2788237_3	1123256.KB907928_gene2001	5.159e-18	84.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,1RMXQ@1236|Gammaproteobacteria,1X4H1@135614|Xanthomonadales	135614|Xanthomonadales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009249,GO:0009987,GO:0010467,GO:0018065,GO:0018193,GO:0018205,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0051604,GO:0071704,GO:1901564	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD1_k127_2788938_1	870187.Thini_2934	8.93e-105	344.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,4601Y@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the GARS family	purD	-	6.3.2.6,6.3.4.13	ko:K01945,ko:K13713	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144,R04591	RC00064,RC00090,RC00162,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N,SAICAR_synt
HKD1_k127_2788938_2	1123368.AUIS01000022_gene1023	2.613e-45	171.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,1S612@1236|Gammaproteobacteria,2NCWD@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD1_k127_2788938_5	1265490.JHVY01000016_gene3555	1.179e-18	89.0	COG3027@1|root,COG3027@2|Bacteria,1N6YN@1224|Proteobacteria,1SCBI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0000921,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006996,GO:0007010,GO:0007049,GO:0008150,GO:0009987,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0030428,GO:0031106,GO:0032153,GO:0032185,GO:0032505,GO:0032506,GO:0034622,GO:0042802,GO:0043093,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0051301,GO:0061640,GO:0065003,GO:0070925,GO:0071840,GO:0090529,GO:1902410,GO:1903047	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD1_k127_2788938_6	767434.Fraau_0404	0.0004293	46.0	2C0ET@1|root,33A9M@2|Bacteria,1NGE5@1224|Proteobacteria,1SGID@1236|Gammaproteobacteria,1X83G@135614|Xanthomonadales	135614|Xanthomonadales	S	TIGRFAM TIGR02449 family protein	VL23_04670	-	-	ko:K09892	-	-	-	-	ko00000,ko03036	-	-	-	ZapB
HKD1_k127_2788938_4	713586.KB900536_gene2595	7.215e-36	144.0	COG3079@1|root,COG3079@2|Bacteria,1N7W0@1224|Proteobacteria,1SCPW@1236|Gammaproteobacteria,1WYR7@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0149 family	-	-	-	ko:K09895	-	-	-	-	ko00000	-	-	-	UPF0149
HKD1_k127_2788938_0	396588.Tgr7_2764	6.509e-182	578.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1WWJH@135613|Chromatiales	135613|Chromatiales	E	peptidase M24B, X-Pro dipeptidase aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD1_k127_2788938_3	765911.Thivi_3384	2.11e-40	154.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,1RMS3@1236|Gammaproteobacteria,1WW09@135613|Chromatiales	135613|Chromatiales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD1_k127_2837916_4	305900.GV64_02000	1.021e-29	123.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,1SYEA@1236|Gammaproteobacteria,1XRJW@135619|Oceanospirillales	135619|Oceanospirillales	S	protein SCO1 SenC PrrC, involved in biogenesis of respiratory and photosynthetic systems	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_2837916_1	472759.Nhal_0269	1.072e-115	379.0	COG2890@1|root,COG2890@2|Bacteria,1MX8Q@1224|Proteobacteria,1RPHQ@1236|Gammaproteobacteria,1WWX2@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue	prmB	-	2.1.1.298	ko:K07320	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03009	-	-	-	MTS
HKD1_k127_2837916_0	1121472.AQWN01000005_gene2447	7.053e-122	396.0	COG1682@1|root,COG1682@2|Bacteria,1TY8I@1239|Firmicutes,25B42@186801|Clostridia,262W8@186807|Peptococcaceae	186801|Clostridia	U	Transport permease protein	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
HKD1_k127_2837916_2	573413.Spirs_0676	5.152e-43	179.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2837916_3	351348.Maqu_1645	8.781e-41	151.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,1RRWB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	PFAM UbiA prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	HAD,UbiA
HKD1_k127_2837937_1	1347369.CCAD010000082_gene2685	3.826e-09	71.0	COG3209@1|root,COG3209@2|Bacteria,1TR8F@1239|Firmicutes,4HBZE@91061|Bacilli,1ZDH9@1386|Bacillus	91061|Bacilli	M	COG3209 Rhs family protein	wapA	GO:0003674,GO:0003824,GO:0004518,GO:0004540,GO:0004549,GO:0006139,GO:0006399,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016078,GO:0016787,GO:0016788,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:0140101,GO:1901360,GO:1901361,GO:1901575	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_2837937_0	323261.Noc_2734	5.191e-149	520.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_2857874_26	765914.ThisiDRAFT_2711	3.577e-11	64.0	COG3385@1|root,COG3385@2|Bacteria,1QFKR@1224|Proteobacteria,1SCE4@1236|Gammaproteobacteria,1X0CD@135613|Chromatiales	135613|Chromatiales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_2857874_2	351348.Maqu_4226	1.865e-144	467.0	COG0675@1|root,COG0675@2|Bacteria,1MUU0@1224|Proteobacteria,1RS1J@1236|Gammaproteobacteria,46A8F@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Probable transposase	gipA	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	HTH_OrfB_IS605,OrfB_IS605,OrfB_Zn_ribbon
HKD1_k127_2857874_5	443143.GM18_2389	1.58e-108	363.0	COG0599@1|root,COG1917@1|root,COG0599@2|Bacteria,COG1917@2|Bacteria,1RH1V@1224|Proteobacteria,42SSF@68525|delta/epsilon subdivisions,2WPME@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2857874_15	1463917.JODC01000023_gene5160	5.957e-37	154.0	COG4925@1|root,COG4925@2|Bacteria,2INIQ@201174|Actinobacteria	201174|Actinobacteria	I	sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cyclophil_like
HKD1_k127_2857874_28	1120972.AUMH01000007_gene1636	4.99e-07	52.0	COG1942@1|root,COG1942@2|Bacteria,1VFV0@1239|Firmicutes	1239|Firmicutes	S	Tautomerase enzyme	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_2857874_25	1122139.KB907866_gene1558	2.215e-20	93.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,1S2JM@1236|Gammaproteobacteria,1XQ3K@135619|Oceanospirillales	135619|Oceanospirillales	S	NADP oxidoreductase coenzyme F420-dependent	-	-	-	-	-	-	-	-	-	-	-	-	F420_oxidored
HKD1_k127_2857874_7	1121106.JQKB01000014_gene5683	1.265e-89	304.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TSHB@28211|Alphaproteobacteria,2JR4X@204441|Rhodospirillales	204441|Rhodospirillales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_2857874_10	1121106.JQKB01000014_gene5683	1.145e-74	259.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TSHB@28211|Alphaproteobacteria,2JR4X@204441|Rhodospirillales	204441|Rhodospirillales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_2857874_16	1510531.JQJJ01000012_gene1748	8.132e-36	138.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TUSA@28211|Alphaproteobacteria,3JW2H@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_2857874_6	1112217.PPL19_11027	1.291e-93	314.0	COG0084@1|root,COG0084@2|Bacteria,1MXN8@1224|Proteobacteria,1RNCC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	3'-5' exonuclease that prefers single-stranded DNA and RNA. May play a role in the H(2)O(2)-induced DNA damage repair	tatD	GO:0000175,GO:0000302,GO:0000738,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004532,GO:0004536,GO:0004540,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008296,GO:0008297,GO:0008310,GO:0008408,GO:0009056,GO:0009057,GO:0009636,GO:0009987,GO:0010035,GO:0016070,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0016896,GO:0019439,GO:0034641,GO:0034655,GO:0042221,GO:0042493,GO:0042542,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046700,GO:0046872,GO:0050896,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090503,GO:0140097,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901700	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_2857874_24	686340.Metal_3725	3.424e-22	104.0	COG1714@1|root,COG1714@2|Bacteria,1N4N8@1224|Proteobacteria,1S9C5@1236|Gammaproteobacteria,1XFBI@135618|Methylococcales	135618|Methylococcales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_2857874_13	2340.JV46_26570	1.053e-39	151.0	COG4831@1|root,COG4831@2|Bacteria,1NMBS@1224|Proteobacteria,1SHJI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_2857874_19	396588.Tgr7_2135	1.16e-27	116.0	COG4831@1|root,COG4831@2|Bacteria,1N4ET@1224|Proteobacteria,1SG6W@1236|Gammaproteobacteria,1X1BI@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_2857874_14	713586.KB900536_gene964	1.981e-39	150.0	COG4831@1|root,COG4831@2|Bacteria,1N55K@1224|Proteobacteria,1T991@1236|Gammaproteobacteria,1X1PP@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized conserved protein (DUF2173)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2173
HKD1_k127_2857874_18	1123487.KB892835_gene3512	7.125e-28	117.0	COG3631@1|root,COG3631@2|Bacteria,1QXIX@1224|Proteobacteria,2WH4R@28216|Betaproteobacteria,2KZY7@206389|Rhodocyclales	206389|Rhodocyclales	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD1_k127_2857874_20	1123368.AUIS01000030_gene1253	1.442e-27	114.0	COG1522@1|root,COG1522@2|Bacteria,1NC1H@1224|Proteobacteria,1SE9N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_2857874_8	1387312.BAUS01000002_gene875	1.107e-83	282.0	COG0764@1|root,COG0764@2|Bacteria,1MWV8@1224|Proteobacteria,2VQ71@28216|Betaproteobacteria,2KM1Q@206350|Nitrosomonadales	206350|Nitrosomonadales	I	Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length	fabA	-	4.2.1.59,5.3.3.14	ko:K01716	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07639	RC00831,RC01078,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_2857874_0	395493.BegalDRAFT_0377	7.911e-195	615.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZXJ@72273|Thiotrichales	72273|Thiotrichales	IQ	Belongs to the beta-ketoacyl-ACP synthases family	-	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_2857874_9	706587.Desti_1910	2.303e-78	285.0	COG2203@1|root,COG4191@1|root,COG4251@1|root,COG2203@2|Bacteria,COG4191@2|Bacteria,COG4251@2|Bacteria,1RCM9@1224|Proteobacteria,43DA0@68525|delta/epsilon subdivisions,2X8GJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_2857874_11	187272.Mlg_0745	1.958e-72	250.0	COG1051@1|root,COG4111@1|root,COG1051@2|Bacteria,COG4111@2|Bacteria,1MXHA@1224|Proteobacteria,1T1QN@1236|Gammaproteobacteria,1WYUW@135613|Chromatiales	135613|Chromatiales	F	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_2857874_1	314278.NB231_01798	2.19e-146	473.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1WWVD@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD1_k127_2857874_12	522306.CAP2UW1_3345	2.748e-71	246.0	COG1309@1|root,COG1309@2|Bacteria,1R52P@1224|Proteobacteria,2VIDN@28216|Betaproteobacteria	28216|Betaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR,TetR_N
HKD1_k127_2857874_17	1121013.P873_02320	3.194e-30	123.0	COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,1SDB2@1236|Gammaproteobacteria,1X717@135614|Xanthomonadales	135614|Xanthomonadales	S	Poly(hydroxyalcanoate) granule associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD1_k127_2857874_4	225937.HP15_464	1.042e-136	447.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD1_k127_2857874_22	349521.HCH_02755	2.042e-25	110.0	COG3937@1|root,COG3937@2|Bacteria,1N7X8@1224|Proteobacteria,1T08C@1236|Gammaproteobacteria,1XQHE@135619|Oceanospirillales	135619|Oceanospirillales	S	Poly(hydroxyalcanoate) granule associated protein (phasin)	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD1_k127_2857874_3	1123073.KB899244_gene406	1.058e-141	466.0	COG1020@1|root,COG1020@2|Bacteria,1N7HY@1224|Proteobacteria,1S1HS@1236|Gammaproteobacteria,1X48P@135614|Xanthomonadales	135614|Xanthomonadales	Q	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD1_k127_2857874_21	267608.RSc1366	3.378e-27	113.0	COG4281@1|root,COG4281@2|Bacteria,1MZPP@1224|Proteobacteria,2VUK0@28216|Betaproteobacteria,1K8JX@119060|Burkholderiaceae	28216|Betaproteobacteria	I	acyl-coa-binding protein	acb	-	-	-	-	-	-	-	-	-	-	-	ACBP
HKD1_k127_2857874_23	768671.ThimaDRAFT_2734	1.394e-22	99.0	COG1483@1|root,COG1483@2|Bacteria,1MX1G@1224|Proteobacteria,1RZYB@1236|Gammaproteobacteria,1WYEQ@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF499)	-	-	-	ko:K06922	-	-	-	-	ko00000	-	-	-	DUF499
HKD1_k127_287502_1	395492.Rleg2_5110	3.558e-68	237.0	COG2370@1|root,COG2370@2|Bacteria,1N08F@1224|Proteobacteria,2UA0Y@28211|Alphaproteobacteria,4B7VB@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	hupE	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03192	-	-	-	-	ko00000	-	-	-	HupE_UreJ
HKD1_k127_287502_2	990285.RGCCGE502_16355	1.206e-33	143.0	COG2370@1|root,COG2370@2|Bacteria,1PPXD@1224|Proteobacteria,2V2C6@28211|Alphaproteobacteria,4BI58@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ
HKD1_k127_287502_4	1267534.KB906755_gene4485	2.864e-27	115.0	2DX6K@1|root,343MI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_287502_3	1353528.DT23_18185	2.212e-31	129.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2XM4U@285107|Thioclava	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_287502_5	1131814.JAFO01000001_gene1962	2.093e-14	77.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,3F17K@335928|Xanthobacteraceae	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_287502_0	1353528.DT23_18185	1.493e-130	432.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2XM4U@285107|Thioclava	28211|Alphaproteobacteria	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_287502_6	41431.PCC8801_2011	0.0005491	44.0	COG2095@1|root,COG2095@2|Bacteria,1G644@1117|Cyanobacteria,3KIRX@43988|Cyanothece	1117|Cyanobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD1_k127_2934736_7	177437.HRM2_25480	1.472e-19	98.0	COG5652@1|root,COG5652@2|Bacteria,1NMI1@1224|Proteobacteria,4331T@68525|delta/epsilon subdivisions,2WY4E@28221|Deltaproteobacteria,2MPBS@213118|Desulfobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD1_k127_2934736_4	1123392.AQWL01000003_gene252	1.084e-196	644.0	COG1752@1|root,COG1752@2|Bacteria,1Q82E@1224|Proteobacteria,2VMYV@28216|Betaproteobacteria,1KRYD@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2934736_0	765913.ThidrDRAFT_3015	0.0	1363.0	COG2010@1|root,COG2010@2|Bacteria,1R58S@1224|Proteobacteria,1RZ9B@1236|Gammaproteobacteria,1WXG4@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2934736_1	663610.JQKO01000006_gene2600	2.741e-319	986.0	COG2303@1|root,COG2303@2|Bacteria,1MV19@1224|Proteobacteria,2TQKQ@28211|Alphaproteobacteria,3NC0H@45404|Beijerinckiaceae	28211|Alphaproteobacteria	E	GMC oxidoreductase	-	-	1.1.99.1	ko:K00108	ko00260,ko01100,map00260,map01100	M00555	R01025	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD1_k127_2934736_3	472759.Nhal_1346	1.092e-252	790.0	COG1858@1|root,COG1858@2|Bacteria	2|Bacteria	C	electron transfer activity	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CCP_MauG,FG-GAP,UnbV_ASPIC,VCBS
HKD1_k127_2934736_2	472759.Nhal_1347	8.333e-260	810.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD1_k127_2934736_6	215803.DB30_3714	1.206e-27	129.0	COG5485@1|root,COG5485@2|Bacteria,1RJSN@1224|Proteobacteria,434UF@68525|delta/epsilon subdivisions,2X911@28221|Deltaproteobacteria,2Z1D8@29|Myxococcales	28221|Deltaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_2934736_5	1122611.KB903969_gene2378	2.049e-74	272.0	COG2124@1|root,COG2124@2|Bacteria,2IAU7@201174|Actinobacteria,4EI5C@85012|Streptosporangiales	201174|Actinobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_2936044_0	472759.Nhal_2771	6.471e-281	878.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,1RM9X@1236|Gammaproteobacteria,1WVXH@135613|Chromatiales	135613|Chromatiales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N,IF2_assoc
HKD1_k127_2936044_2	713586.KB900536_gene3061	3.2e-34	135.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,1S9AF@1236|Gammaproteobacteria,1WYHM@135613|Chromatiales	135613|Chromatiales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD1_k127_2936044_1	754476.Q7A_983	3.208e-59	216.0	COG0596@1|root,COG0596@2|Bacteria,1N252@1224|Proteobacteria,1SDH5@1236|Gammaproteobacteria,462GG@72273|Thiotrichales	72273|Thiotrichales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_2936044_3	243233.MCA1944	1.168e-14	76.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,1RM9E@1236|Gammaproteobacteria,1XGYY@135618|Methylococcales	135618|Methylococcales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran
HKD1_k127_2963752_6	1280663.ATVR01000003_gene171	6.475e-21	104.0	COG3209@1|root,COG3209@2|Bacteria,1UPAD@1239|Firmicutes,25H9K@186801|Clostridia,4BZBB@830|Butyrivibrio	186801|Clostridia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2963752_8	699246.HMPREF0868_1553	0.0001246	53.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,267R3@186813|unclassified Clostridiales	186801|Clostridia	M	tail specific protease	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD1_k127_2963752_3	1379281.AVAG01000007_gene1237	5.055e-137	441.0	COG1227@1|root,COG1227@2|Bacteria,1P9JN@1224|Proteobacteria,42N0W@68525|delta/epsilon subdivisions,2WK0Q@28221|Deltaproteobacteria,2M998@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	phosphoesterase RecJ domain protein	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD1_k127_2963752_2	1095769.CAHF01000006_gene1914	4.593e-186	589.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,472XC@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	ThiF family	thiF	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD1_k127_2963752_0	187272.Mlg_1430	1.24e-244	783.0	COG1530@1|root,COG3266@1|root,COG1530@2|Bacteria,COG3266@2|Bacteria,1MV65@1224|Proteobacteria,1RMDS@1236|Gammaproteobacteria,1WXN6@135613|Chromatiales	135613|Chromatiales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD1_k127_2963752_7	504728.K649_04105	1.521e-14	78.0	COG1669@1|root,COG1669@2|Bacteria,1WK3Y@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD1_k127_2963752_4	592015.HMPREF1705_00607	5.287e-36	140.0	COG2445@1|root,COG2445@2|Bacteria,3TBPJ@508458|Synergistetes	508458|Synergistetes	S	Protein of unknown function DUF86	-	-	-	-	-	-	-	-	-	-	-	-	DUF86
HKD1_k127_2963752_5	163908.KB235896_gene3917	2.944e-21	97.0	2EAP2@1|root,334RJ@2|Bacteria,1GA1Z@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2963752_9	1189619.pgond44_09096	0.0005298	45.0	COG5654@1|root,COG5654@2|Bacteria,4NQ91@976|Bacteroidetes,1I22I@117743|Flavobacteriia,4C49I@83612|Psychroflexus	976|Bacteroidetes	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD1_k127_2963752_1	314278.NB231_10293	2.233e-200	647.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,1RQVZ@1236|Gammaproteobacteria,1WW36@135613|Chromatiales	135613|Chromatiales	E	PFAM NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HKD1_k127_2965667_5	1169143.KB911037_gene3943	0.0003133	43.0	COG3408@1|root,COG3408@2|Bacteria,1QUN2@1224|Proteobacteria,2WHH3@28216|Betaproteobacteria,1KIP3@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Glycogen debranching enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_2965667_3	240016.ABIZ01000001_gene3215	2.739e-09	59.0	COG2067@1|root,COG2067@2|Bacteria,46X75@74201|Verrucomicrobia,2IUTY@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD1_k127_2965667_1	631362.Thi970DRAFT_01797	3.823e-27	119.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,1SAC1@1236|Gammaproteobacteria,1WZ89@135613|Chromatiales	135613|Chromatiales	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2965667_0	933262.AXAM01000046_gene131	6.976e-36	139.0	COG0778@1|root,COG1145@1|root,COG0778@2|Bacteria,COG1145@2|Bacteria,1R42D@1224|Proteobacteria,42Q57@68525|delta/epsilon subdivisions,2WNIW@28221|Deltaproteobacteria,2MIDH@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4,Fer4_7,Fer4_9,Nitroreductase
HKD1_k127_2965667_4	395964.KE386496_gene2043	0.0002626	45.0	2E8Y7@1|root,3337X@2|Bacteria,1NBJG@1224|Proteobacteria,2UW7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2965667_2	1532558.JL39_15395	1.889e-19	92.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,2VEWI@28211|Alphaproteobacteria,4BN8Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD1_k127_2983643_11	519989.ECTPHS_07326	1.95e-51	185.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_2983643_13	765910.MARPU_16070	6.677e-28	115.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1WXCF@135613|Chromatiales	135613|Chromatiales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_2983643_4	930169.B5T_00189	7.529e-115	378.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,1RMKQ@1236|Gammaproteobacteria,1XIHN@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_2983643_10	396588.Tgr7_0103	1.061e-71	244.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,1S233@1236|Gammaproteobacteria,1WXYJ@135613|Chromatiales	135613|Chromatiales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD1_k127_2983643_2	768671.ThimaDRAFT_2715	1.267e-138	446.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,1RNKK@1236|Gammaproteobacteria,1WWCV@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_2983643_0	1187851.A33M_1375	2.747e-252	799.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2TUMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C,SNF2_N
HKD1_k127_2983643_6	1187851.A33M_1376	1.281e-96	329.0	290SS@1|root,2ZNEW@2|Bacteria,1RBZK@1224|Proteobacteria,2UR19@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2983643_7	395493.BegalDRAFT_3427	8.02e-89	302.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,1RMX5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	GO:0002252,GO:0002376,GO:0003674,GO:0003824,GO:0006464,GO:0006476,GO:0006807,GO:0006935,GO:0006950,GO:0006952,GO:0008150,GO:0008152,GO:0009605,GO:0009607,GO:0009615,GO:0009987,GO:0016787,GO:0016810,GO:0016811,GO:0018193,GO:0018205,GO:0019213,GO:0019538,GO:0033558,GO:0034979,GO:0034983,GO:0035601,GO:0036048,GO:0036049,GO:0036055,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043207,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050896,GO:0051607,GO:0051704,GO:0051707,GO:0071704,GO:0098542,GO:0098732,GO:0140096,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD1_k127_2983643_14	234267.Acid_4282	1.13e-26	114.0	COG5485@1|root,COG5485@2|Bacteria,3Y8NT@57723|Acidobacteria	57723|Acidobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_2983643_12	690850.Desaf_2040	9.869e-29	125.0	COG0546@1|root,COG0546@2|Bacteria,1P7U4@1224|Proteobacteria,432VF@68525|delta/epsilon subdivisions,2WYF8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	HAD-hyrolase-like	gph1	-	-	-	-	-	-	-	-	-	-	-	HAD,Hydrolase_like
HKD1_k127_2983643_8	1121861.KB899913_gene2168	7.881e-86	291.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,2JQD5@204441|Rhodospirillales	204441|Rhodospirillales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD1_k127_2983643_9	1123355.JHYO01000017_gene3628	2.84e-84	285.0	COG4662@1|root,COG4662@2|Bacteria,1MZVS@1224|Proteobacteria,2TUHN@28211|Alphaproteobacteria,36ZY7@31993|Methylocystaceae	28211|Alphaproteobacteria	H	ABC-type tungstate transport system, periplasmic component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD1_k127_2983643_3	391613.RTM1035_17820	5e-119	388.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2TU33@28211|Alphaproteobacteria,46NNP@74030|Roseovarius	28211|Alphaproteobacteria	P	Sulfate tungstate uptake family ABC transporter, periplasmic substrate-binding protein	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_2983643_5	396588.Tgr7_1128	2.531e-104	349.0	COG0845@1|root,COG0845@2|Bacteria,1NQZ0@1224|Proteobacteria,1RR67@1236|Gammaproteobacteria,1WX31@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_2983643_1	396588.Tgr7_1129	1.036e-235	738.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_3005962_4	243233.MCA1833	3.144e-122	396.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,1RNVG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
HKD1_k127_3005962_7	1242864.D187_001577	3.762e-92	316.0	COG3420@1|root,COG3420@2|Bacteria,1R5QH@1224|Proteobacteria	1224|Proteobacteria	P	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD1_k127_3005962_18	1236501.BAJU01000002_gene356	5.793e-20	97.0	2E560@1|root,32ZYT@2|Bacteria,1RD6P@1224|Proteobacteria,2UJ9J@28211|Alphaproteobacteria,2JXYX@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3005962_12	1397528.Q671_00585	2.968e-34	139.0	COG0791@1|root,COG0791@2|Bacteria,1N0EE@1224|Proteobacteria,1RP3P@1236|Gammaproteobacteria,1XS8J@135619|Oceanospirillales	135619|Oceanospirillales	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD1_k127_3005962_10	472759.Nhal_3929	3.449e-65	231.0	COG0850@1|root,COG0850@2|Bacteria,1RHVN@1224|Proteobacteria,1S6K8@1236|Gammaproteobacteria,1WW2J@135613|Chromatiales	135613|Chromatiales	D	Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization	minC	-	-	ko:K03610	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinC_C,MinC_N
HKD1_k127_3005962_3	1316927.ATKI01000060_gene4004	7.242e-131	422.0	COG2894@1|root,COG2894@2|Bacteria,1MUEU@1224|Proteobacteria,1RNJ0@1236|Gammaproteobacteria,1YMTK@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	D	Belongs to the ParA family	minD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0007059,GO:0008144,GO:0008150,GO:0009898,GO:0009987,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0031224,GO:0031226,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051301,GO:0051302,GO:0051782,GO:0060187,GO:0065007,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA
HKD1_k127_3005962_15	243233.MCA3068	4.87e-24	103.0	COG0851@1|root,COG0851@2|Bacteria,1N6QD@1224|Proteobacteria,1SC8W@1236|Gammaproteobacteria,1XFJ0@135618|Methylococcales	135618|Methylococcales	D	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell	minE	-	-	ko:K03608	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MinE
HKD1_k127_3005962_11	472759.Nhal_2693	1.952e-35	139.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,1S8VU@1236|Gammaproteobacteria,1WYI6@135613|Chromatiales	135613|Chromatiales	J	Belongs to the HSP15 family	-	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD1_k127_3005962_19	1123502.AQXD01000001_gene592	1.706e-14	79.0	COG3109@1|root,COG3109@2|Bacteria,1QCSH@1224|Proteobacteria,1T8JB@1236|Gammaproteobacteria,1XATY@135614|Xanthomonadales	135614|Xanthomonadales	T	ProQ/FINO family	-	-	-	-	-	-	-	-	-	-	-	-	ProQ
HKD1_k127_3005962_2	472759.Nhal_2165	1.9e-192	608.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RM8C@1236|Gammaproteobacteria,1WWUM@135613|Chromatiales	135613|Chromatiales	E	PFAM Orn DAP Arg decarboxylase 2	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_3005962_1	472759.Nhal_2166	4.033e-234	737.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1T1II@1236|Gammaproteobacteria,1WW6V@135613|Chromatiales	135613|Chromatiales	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_3005962_14	105559.Nwat_0327	4.853e-30	121.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,1SCKA@1236|Gammaproteobacteria,1WYKM@135613|Chromatiales	135613|Chromatiales	S	RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3005962_0	754477.Q7C_572	8.829e-311	964.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,1RNBF@1236|Gammaproteobacteria,4601N@72273|Thiotrichales	72273|Thiotrichales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_3005962_13	1123502.AQXD01000003_gene1608	3.394e-32	126.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,1S8U6@1236|Gammaproteobacteria,1X7EJ@135614|Xanthomonadales	135614|Xanthomonadales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015935,GO:0022626,GO:0022627,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD1_k127_3005962_5	396588.Tgr7_1005	1.81e-109	362.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,1RMKP@1236|Gammaproteobacteria,1WVXW@135613|Chromatiales	135613|Chromatiales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD1_k127_3005962_17	414684.RC1_0855	8.823e-22	96.0	COG2841@1|root,COG2841@2|Bacteria,1NNR7@1224|Proteobacteria,2UFB8@28211|Alphaproteobacteria,2JUSF@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF465)	-	-	-	ko:K09794	-	-	-	-	ko00000	-	-	-	DUF465
HKD1_k127_3005962_16	1122599.AUGR01000008_gene2592	6.282e-24	102.0	COG0236@1|root,COG0236@2|Bacteria,1N83X@1224|Proteobacteria,1SD6R@1236|Gammaproteobacteria,1XMKW@135619|Oceanospirillales	135619|Oceanospirillales	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD1_k127_3005962_9	187272.Mlg_0132	1.251e-79	275.0	COG1073@1|root,COG1216@1|root,COG1073@2|Bacteria,COG1216@2|Bacteria,1MZSD@1224|Proteobacteria,1S9D2@1236|Gammaproteobacteria,1X2DR@135613|Chromatiales	135613|Chromatiales	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_3005962_6	1158760.AQXP01000053_gene1476	4.495e-103	343.0	COG1073@1|root,COG1073@2|Bacteria,1R61B@1224|Proteobacteria,1S0E7@1236|Gammaproteobacteria,1WYBD@135613|Chromatiales	135613|Chromatiales	T	TIGRFAM Hydrolase, ortholog 1, exosortase system type 1 associated	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,Hydrolase_4
HKD1_k127_3005962_8	857087.Metme_3907	6.715e-86	303.0	COG5652@1|root,COG5652@2|Bacteria,1QUYG@1224|Proteobacteria,1T5BX@1236|Gammaproteobacteria,1XGA1@135618|Methylococcales	135618|Methylococcales	S	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD1_k127_3012477_1	105559.Nwat_1524	9.917e-179	565.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1WXP7@135613|Chromatiales	135613|Chromatiales	C	Pyridine nucleotide-disulphide oxidoreductase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_3012477_8	357808.RoseRS_4461	1.594e-21	101.0	COG4636@1|root,COG4636@2|Bacteria,2G8R4@200795|Chloroflexi	200795|Chloroflexi	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_3012477_3	909663.KI867150_gene818	1.444e-95	324.0	COG4191@1|root,COG4191@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
HKD1_k127_3012477_7	69395.JQLZ01000006_gene2149	9.26e-61	214.0	COG1028@1|root,COG1028@2|Bacteria,1MWGK@1224|Proteobacteria,2TVQ8@28211|Alphaproteobacteria,2KFD8@204458|Caulobacterales	204458|Caulobacterales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_3012477_2	1485544.JQKP01000007_gene1966	2.726e-159	520.0	COG0297@1|root,COG0297@2|Bacteria,1MUGM@1224|Proteobacteria,2VH1G@28216|Betaproteobacteria,44V0E@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Starch synthase catalytic domain	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_3012477_0	886293.Sinac_4963	2.188e-183	581.0	COG0297@1|root,COG0297@2|Bacteria	2|Bacteria	G	glycogen (starch) synthase activity	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0071704,GO:1901576	2.4.1.342	ko:K16148	ko00500,ko01100,map00500,map01100	-	R02421,R11530	RC00005,RC00049,RC02748	ko00000,ko00001,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3012477_9	1283300.ATXB01000001_gene336	2.986e-20	95.0	COG2214@1|root,COG2214@2|Bacteria,1PUS9@1224|Proteobacteria,1SER6@1236|Gammaproteobacteria,1XFCY@135618|Methylococcales	135618|Methylococcales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD1_k127_3012477_5	323261.Noc_1605	4.821e-72	246.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,1S400@1236|Gammaproteobacteria,1WYBM@135613|Chromatiales	135613|Chromatiales	S	PFAM Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_3012477_6	1499967.BAYZ01000075_gene2071	5.367e-71	261.0	COG1925@1|root,COG1925@2|Bacteria	2|Bacteria	G	phosphoenolpyruvate-dependent sugar phosphotransferase system	-	-	2.7.1.121	ko:K05881	ko00561,map00561	-	R01012	RC00015,RC00017	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS-HPr
HKD1_k127_3012477_4	215803.DB30_4149	5.475e-95	318.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,42QA7@68525|delta/epsilon subdivisions,2WM2Q@28221|Deltaproteobacteria,2YZTN@29|Myxococcales	28221|Deltaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_304827_7	313624.NSP_49630	0.0005401	43.0	COG2170@1|root,COG2170@2|Bacteria,1G6F1@1117|Cyanobacteria,1HPDI@1161|Nostocales	1117|Cyanobacteria	F	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	-	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD1_k127_304827_1	243233.MCA0717	7.38e-91	306.0	COG4322@1|root,COG4322@2|Bacteria,1R4WQ@1224|Proteobacteria,1SZ11@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Uncharacterized protein conserved in bacteria (DUF2272)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2272
HKD1_k127_304827_4	903818.KI912268_gene1777	8.867e-15	78.0	COG2929@1|root,COG2929@2|Bacteria,3Y5X2@57723|Acidobacteria	57723|Acidobacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD1_k127_304827_5	247490.KSU1_A0078	6.057e-06	49.0	COG0680@1|root,COG0680@2|Bacteria,2J190@203682|Planctomycetes	203682|Planctomycetes	C	Hydrogenase maturation protease	-	-	-	-	-	-	-	-	-	-	-	-	HycI
HKD1_k127_304827_6	102125.Xen7305DRAFT_00011600	3.438e-05	51.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,NB-ARC,TIR_2,TPR_10,TPR_12,TPR_7
HKD1_k127_304827_0	1380391.JIAS01000014_gene2239	6.195e-164	526.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,2JQKW@204441|Rhodospirillales	204441|Rhodospirillales	F	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis	deoA	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD1_k127_304827_2	349521.HCH_03074	4.867e-71	249.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,1RPTS@1236|Gammaproteobacteria,1XJCD@135619|Oceanospirillales	135619|Oceanospirillales	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD1_k127_304827_3	1380394.JADL01000012_gene1064	2.863e-21	93.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,2JSQC@204441|Rhodospirillales	204441|Rhodospirillales	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
HKD1_k127_3070065_1	1499967.BAYZ01000136_gene29	8.013e-29	121.0	COG2929@1|root,COG2929@2|Bacteria,2NRXP@2323|unclassified Bacteria	2|Bacteria	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	ko:K09803	-	-	-	-	ko00000	-	-	-	BrnT_toxin
HKD1_k127_3070065_0	1125863.JAFN01000001_gene636	9.505e-66	237.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,42RIE@68525|delta/epsilon subdivisions,2WNU1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_3070065_3	1255043.TVNIR_3868	2.083e-15	79.0	COG2442@1|root,COG2442@2|Bacteria,1N8Z1@1224|Proteobacteria,1SEX2@1236|Gammaproteobacteria,1X23W@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_3070065_4	1331060.RLDS_00965	6.42e-14	82.0	28M9I@1|root,2ZANF@2|Bacteria,1R82B@1224|Proteobacteria,2UPPN@28211|Alphaproteobacteria,2K9EM@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3079585_5	497965.Cyan7822_0262	1.429e-12	68.0	COG0697@1|root,COG0697@2|Bacteria,1G0QG@1117|Cyanobacteria,3KHSB@43988|Cyanothece	1117|Cyanobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3079585_0	1337936.IJ00_19125	6.964e-239	746.0	COG0635@1|root,COG0635@2|Bacteria,1G0BZ@1117|Cyanobacteria,1HKQT@1161|Nostocales	1117|Cyanobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_3079585_2	1283300.ATXB01000002_gene2875	1.114e-125	415.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,1RN0E@1236|Gammaproteobacteria,1XF94@135618|Methylococcales	135618|Methylococcales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_3079585_3	472759.Nhal_2257	1.42e-106	349.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,1RNUJ@1236|Gammaproteobacteria,1WWSW@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3079585_1	318167.Sfri_1812	2.76e-162	520.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,1T1FT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	ABC-type antimicrobial peptide transport system, permease component	-	-	-	ko:K02004,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	FtsX,MacB_PCD
HKD1_k127_3079585_4	251229.Chro_4255	3.104e-27	114.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,3VINB@52604|Pleurocapsales	1117|Cyanobacteria	E	Amino acid polyamine organocation transporter, APC superfamily	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_3101448_0	1380355.JNIJ01000068_gene5655	1e-185	618.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,2TRIX@28211|Alphaproteobacteria,3K05Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TIR_2,WD40
HKD1_k127_3101448_3	1210884.HG799466_gene13044	1.173e-40	155.0	COG1403@1|root,COG1403@2|Bacteria,2J3RR@203682|Planctomycetes	203682|Planctomycetes	L	HNH nucleases	-	-	-	-	-	-	-	-	-	-	-	-	HNH
HKD1_k127_3101448_9	107636.JQNK01000003_gene904	9.586e-14	71.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_3101448_10	107636.JQNK01000003_gene904	1.843e-09	59.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_3101448_5	391616.OA238_c38840	9.088e-35	135.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_3101448_11	1499967.BAYZ01000108_gene2207	1.268e-06	55.0	2946W@1|root,2ZRMA@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3101448_13	1499967.BAYZ01000108_gene2207	0.0001157	47.0	2946W@1|root,2ZRMA@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3101448_8	686340.Metal_2367	1.119e-16	80.0	COG3385@1|root,COG3385@2|Bacteria,1NIWM@1224|Proteobacteria,1S5FT@1236|Gammaproteobacteria,1XFX0@135618|Methylococcales	135618|Methylococcales	L	PFAM Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_3101448_2	485913.Krac_1480	2.38e-43	161.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_3101448_1	765911.Thivi_1477	1.925e-47	174.0	COG3654@1|root,COG3654@2|Bacteria,1N1FW@1224|Proteobacteria,1SFPB@1236|Gammaproteobacteria,1WZAI@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM death-on-curing family protein	-	-	-	ko:K07341	-	-	-	-	ko00000,ko02048	-	-	-	Fic
HKD1_k127_3101448_6	765911.Thivi_1478	3.197e-31	123.0	COG2336@1|root,COG2336@2|Bacteria,1N7UD@1224|Proteobacteria,1T4ID@1236|Gammaproteobacteria,1WZMG@135613|Chromatiales	135613|Chromatiales	T	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3101448_7	159087.Daro_1303	1.184e-18	86.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VHBK@28216|Betaproteobacteria,2KVTF@206389|Rhodocyclales	206389|Rhodocyclales	V	COG0286 Type I restriction-modification system methyltransferase subunit	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
HKD1_k127_3101448_4	123899.JPQP01000022_gene3303	2.963e-36	140.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VHBK@28216|Betaproteobacteria,3T1TQ@506|Alcaligenaceae	28216|Betaproteobacteria	V	HsdM N-terminal domain	hsdM	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HsdM_N,N6_Mtase
HKD1_k127_3110840_1	1095769.CAHF01000018_gene820	4.449e-149	475.0	COG1274@1|root,COG1274@2|Bacteria,1MX3C@1224|Proteobacteria,2VINZ@28216|Betaproteobacteria,472VX@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	GO:0000003,GO:0001655,GO:0001822,GO:0001889,GO:0003006,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003824,GO:0004457,GO:0004611,GO:0004613,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005739,GO:0005759,GO:0005975,GO:0005996,GO:0006006,GO:0006007,GO:0006066,GO:0006071,GO:0006082,GO:0006089,GO:0006090,GO:0006091,GO:0006094,GO:0006109,GO:0006111,GO:0006113,GO:0006139,GO:0006163,GO:0006464,GO:0006629,GO:0006631,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0007028,GO:0007275,GO:0007276,GO:0007281,GO:0007292,GO:0007296,GO:0007610,GO:0008150,GO:0008152,GO:0008906,GO:0009056,GO:0009058,GO:0009062,GO:0009117,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009166,GO:0009167,GO:0009179,GO:0009185,GO:0009199,GO:0009205,GO:0009259,GO:0009410,GO:0009605,GO:0009636,GO:0009653,GO:0009719,GO:0009725,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009889,GO:0009966,GO:0009967,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010646,GO:0010647,GO:0010675,GO:0010906,GO:0014070,GO:0014074,GO:0015036,GO:0015980,GO:0016042,GO:0016043,GO:0016051,GO:0016052,GO:0016053,GO:0016054,GO:0016301,GO:0016310,GO:0016491,GO:0016614,GO:0016651,GO:0016667,GO:0016668,GO:0016740,GO:0016772,GO:0016773,GO:0016829,GO:0016830,GO:0016831,GO:0016999,GO:0017001,GO:0017144,GO:0018130,GO:0018991,GO:0019098,GO:0019222,GO:0019249,GO:0019318,GO:0019319,GO:0019320,GO:0019362,GO:0019400,GO:0019405,GO:0019438,GO:0019439,GO:0019516,GO:0019538,GO:0019541,GO:0019543,GO:0019563,GO:0019626,GO:0019637,GO:0019659,GO:0019660,GO:0019661,GO:0019666,GO:0019674,GO:0019693,GO:0019751,GO:0019752,GO:0019953,GO:0022412,GO:0022414,GO:0023051,GO:0023056,GO:0030145,GO:0030154,GO:0030703,GO:0030855,GO:0031323,GO:0031667,GO:0031960,GO:0031974,GO:0032501,GO:0032502,GO:0032504,GO:0032787,GO:0032868,GO:0032869,GO:0032870,GO:0033993,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035690,GO:0036211,GO:0042221,GO:0042493,GO:0042594,GO:0042737,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043255,GO:0043412,GO:0043434,GO:0043436,GO:0043687,GO:0043900,GO:0043903,GO:0043949,GO:0043950,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044267,GO:0044270,GO:0044271,GO:0044275,GO:0044281,GO:0044282,GO:0044283,GO:0044422,GO:0044424,GO:0044429,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0045471,GO:0046031,GO:0046034,GO:0046164,GO:0046174,GO:0046364,GO:0046365,GO:0046394,GO:0046395,GO:0046434,GO:0046459,GO:0046483,GO:0046496,GO:0046677,GO:0046683,GO:0046700,GO:0046872,GO:0046914,GO:0047134,GO:0048468,GO:0048477,GO:0048513,GO:0048518,GO:0048522,GO:0048545,GO:0048562,GO:0048568,GO:0048583,GO:0048584,GO:0048598,GO:0048609,GO:0048646,GO:0048731,GO:0048732,GO:0048856,GO:0048869,GO:0050789,GO:0050792,GO:0050794,GO:0050896,GO:0051186,GO:0051384,GO:0051591,GO:0051704,GO:0051716,GO:0055086,GO:0055114,GO:0060429,GO:0061005,GO:0061008,GO:0062012,GO:0065007,GO:0070013,GO:0070365,GO:0070887,GO:0071236,GO:0071310,GO:0071361,GO:0071375,GO:0071383,GO:0071384,GO:0071385,GO:0071396,GO:0071407,GO:0071417,GO:0071466,GO:0071495,GO:0071548,GO:0071549,GO:0071704,GO:0071840,GO:0072001,GO:0072071,GO:0072329,GO:0072330,GO:0072521,GO:0072524,GO:0080090,GO:0097159,GO:0097237,GO:0097305,GO:0097306,GO:0097327,GO:1901135,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901363,GO:1901564,GO:1901575,GO:1901576,GO:1901615,GO:1901616,GO:1901617,GO:1901652,GO:1901653,GO:1901654,GO:1901655,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902531,GO:1902533	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD1_k127_3110840_2	187272.Mlg_0994	1.232e-105	347.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1WXR9@135613|Chromatiales	135613|Chromatiales	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short
HKD1_k127_3110840_0	1380391.JIAS01000001_gene2770	2.16e-306	949.0	COG0365@1|root,COG0365@2|Bacteria,1MUX7@1224|Proteobacteria,2TRND@28211|Alphaproteobacteria,2JPUS@204441|Rhodospirillales	204441|Rhodospirillales	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	-	-	6.2.1.16	ko:K01907	ko00280,ko00650,map00280,map00650	-	R01357	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_3110840_3	126957.SMAR010971-PA	1.193e-54	199.0	COG1028@1|root,KOG1201@2759|Eukaryota,38DUA@33154|Opisthokonta,3B9V8@33208|Metazoa,3CS2U@33213|Bilateria,41XM0@6656|Arthropoda	33208|Metazoa	Q	Belongs to the short-chain dehydrogenases reductases (SDR) family	SDR16C5	GO:0000122,GO:0000988,GO:0000989,GO:0001076,GO:0001191,GO:0001523,GO:0003674,GO:0003824,GO:0004745,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005783,GO:0005789,GO:0005811,GO:0006066,GO:0006081,GO:0006355,GO:0006357,GO:0006629,GO:0006720,GO:0006721,GO:0006950,GO:0008134,GO:0008150,GO:0008152,GO:0008283,GO:0009889,GO:0009890,GO:0009892,GO:0009893,GO:0009987,GO:0010468,GO:0010556,GO:0010558,GO:0010604,GO:0010605,GO:0010629,GO:0010638,GO:0010639,GO:0010817,GO:0012505,GO:0016020,GO:0016101,GO:0016491,GO:0016614,GO:0016616,GO:0017053,GO:0019219,GO:0019222,GO:0031056,GO:0031057,GO:0031058,GO:0031063,GO:0031065,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031399,GO:0031400,GO:0031401,GO:0031984,GO:0032268,GO:0032269,GO:0032270,GO:0032501,GO:0032991,GO:0033043,GO:0033044,GO:0033555,GO:0033613,GO:0034308,GO:0034754,GO:0035065,GO:0035067,GO:0042175,GO:0042445,GO:0042572,GO:0042574,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043616,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0044422,GO:0044424,GO:0044425,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0045892,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050673,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0051252,GO:0051253,GO:0055114,GO:0060255,GO:0065007,GO:0065008,GO:0071704,GO:0080090,GO:0090311,GO:0090312,GO:0098827,GO:0140110,GO:1901615,GO:1901983,GO:1901984,GO:1902275,GO:1902679,GO:1903506,GO:1903507,GO:1905268,GO:1905269,GO:2000112,GO:2000113,GO:2000756,GO:2000757,GO:2001141,GO:2001251,GO:2001252	1.1.1.105	ko:K11151,ko:K15734	ko00830,ko01100,map00830,map01100	-	R02124,R03048,R08379,R08380	RC00649	ko00000,ko00001,ko01000	-	-	-	adh_short
HKD1_k127_3128192_5	543632.JOJL01000070_gene3170	2.388e-15	77.0	COG0366@1|root,COG0366@2|Bacteria,2GN52@201174|Actinobacteria	201174|Actinobacteria	G	Alpha amylase catalytic	amyA	-	-	-	-	-	-	-	-	-	-	-	Alpha-amylase
HKD1_k127_3128192_0	335543.Sfum_1474	1.082e-38	153.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	mshD	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0008080,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0017076,GO:0030551,GO:0030552,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	2.3.1.189	ko:K09181,ko:K15520	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_3,cNMP_binding
HKD1_k127_3128192_6	102129.Lepto7375DRAFT_0764	9.681e-12	74.0	COG3464@1|root,COG3464@2|Bacteria,1G9CU@1117|Cyanobacteria,1HGU0@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3128192_4	102232.GLO73106DRAFT_00035810	7.073e-24	101.0	COG1724@1|root,COG1724@2|Bacteria,1GAH0@1117|Cyanobacteria	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_3128192_3	522306.CAP2UW1_2699	1.893e-27	114.0	2EE2B@1|root,337X1@2|Bacteria,1N433@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3128192_2	572477.Alvin_1299	1.965e-28	124.0	COG5380@1|root,COG5380@2|Bacteria,1N6UY@1224|Proteobacteria,1S03R@1236|Gammaproteobacteria,1WX19@135613|Chromatiales	135613|Chromatiales	O	lipid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3176897_7	187272.Mlg_0809	7.563e-86	286.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,1RMHU@1236|Gammaproteobacteria,1WW35@135613|Chromatiales	135613|Chromatiales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_3176897_13	187272.Mlg_0808	1.868e-40	160.0	2AFCJ@1|root,315C6@2|Bacteria,1RH66@1224|Proteobacteria,1S9MI@1236|Gammaproteobacteria,1WYGK@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF1841)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1841
HKD1_k127_3176897_11	1049564.TevJSym_bw00050	9.065e-49	181.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,1S90I@1236|Gammaproteobacteria,1J6NV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma-70, region 4	sigK	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_3176897_16	1177179.A11A3_07068	5.013e-26	116.0	COG5343@1|root,COG5343@2|Bacteria,1N821@1224|Proteobacteria,1SAB3@1236|Gammaproteobacteria,1XKPP@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HKD1_k127_3176897_15	1123054.KB907702_gene1604	6.683e-27	117.0	2FJ2N@1|root,34ASZ@2|Bacteria,1P31M@1224|Proteobacteria,1SRU1@1236|Gammaproteobacteria,1X194@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3176897_6	1288494.EBAPG3_28720	2.943e-142	456.0	COG5653@1|root,COG5653@2|Bacteria,1RAB9@1224|Proteobacteria,2W65I@28216|Betaproteobacteria,371WF@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_3176897_3	1266925.JHVX01000005_gene1899	1.441e-154	494.0	COG0726@1|root,COG0726@2|Bacteria,1RDB8@1224|Proteobacteria,2VY2J@28216|Betaproteobacteria,372Q3@32003|Nitrosomonadales	28216|Betaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3176897_14	1123253.AUBD01000007_gene614	4.056e-36	139.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,1S5VB@1236|Gammaproteobacteria,1X6XJ@135614|Xanthomonadales	135614|Xanthomonadales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	GO:0003674,GO:0003735,GO:0005198	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD1_k127_3176897_12	519989.ECTPHS_04044	7.345e-41	154.0	COG0211@1|root,COG0211@2|Bacteria,1MZGH@1224|Proteobacteria,1S8R2@1236|Gammaproteobacteria,1WYVD@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD1_k127_3176897_4	713586.KB900536_gene1912	3.648e-154	494.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,1RMFQ@1236|Gammaproteobacteria,1WX4T@135613|Chromatiales	135613|Chromatiales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD1_k127_3176897_5	187272.Mlg_0848	2.285e-146	472.0	COG0263@1|root,COG0263@2|Bacteria,1MUBG@1224|Proteobacteria,1RM7X@1236|Gammaproteobacteria,1WWMC@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HKD1_k127_3176897_20	1124780.ANNU01000036_gene9	1.996e-06	61.0	COG1807@1|root,COG1807@2|Bacteria,4NZXF@976|Bacteroidetes,47TP6@768503|Cytophagia	976|Bacteroidetes	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3176897_8	1192034.CAP_7123	5.972e-73	258.0	COG0726@1|root,COG0726@2|Bacteria,1RFCG@1224|Proteobacteria,43BYQ@68525|delta/epsilon subdivisions,2X79K@28221|Deltaproteobacteria,2Z21H@29|Myxococcales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_3176897_17	187272.Mlg_0849	4.197e-25	110.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,1S9AI@1236|Gammaproteobacteria,1WYU8@135613|Chromatiales	135613|Chromatiales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD1_k127_3176897_19	305700.B447_14994	4.992e-08	58.0	COG0675@1|root,COG0675@2|Bacteria,1R612@1224|Proteobacteria,2VNQJ@28216|Betaproteobacteria	28216|Betaproteobacteria	L	transposase, IS891 IS1136 IS1341 family	-	-	-	ko:K07496	-	-	-	-	ko00000	-	-	-	OrfB_IS605,OrfB_Zn_ribbon
HKD1_k127_3176897_2	1429916.X566_17500	2.321e-160	513.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,2TRIQ@28211|Alphaproteobacteria,3JSYW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	MA20_07980	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_3176897_18	187272.Mlg_2791	3.987e-22	100.0	COG4391@1|root,COG4391@2|Bacteria,1N7QM@1224|Proteobacteria,1SHHF@1236|Gammaproteobacteria,1WZR6@135613|Chromatiales	135613|Chromatiales	S	Zinc-finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HKD1_k127_3176897_1	323261.Noc_0136	4.467e-167	528.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,1RP6Z@1236|Gammaproteobacteria,1WW7W@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_3176897_0	519989.ECTPHS_06822	6.317e-310	977.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,1RP9N@1236|Gammaproteobacteria,1WXIK@135613|Chromatiales	135613|Chromatiales	OT	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD1_k127_3176897_9	933262.AXAM01000002_gene548	2.61e-59	212.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,42TXX@68525|delta/epsilon subdivisions,2WQBC@28221|Deltaproteobacteria,2MK1I@213118|Desulfobacterales	28221|Deltaproteobacteria	S	hydrolase of the alpha beta superfamily	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4,Peptidase_S15
HKD1_k127_3176897_10	748247.AZKH_2909	2.799e-53	194.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2VIEB@28216|Betaproteobacteria,2KY1I@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,POR_N
HKD1_k127_3177945_0	396588.Tgr7_0080	6.68e-240	757.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,1RNJI@1236|Gammaproteobacteria,1WWI3@135613|Chromatiales	135613|Chromatiales	L	PFAM UvrD REP helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_3177945_2	572477.Alvin_0986	5.339e-44	162.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,1S61Z@1236|Gammaproteobacteria,1WYKZ@135613|Chromatiales	135613|Chromatiales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_3177945_1	765910.MARPU_05545	4.935e-82	279.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD1_k127_3182564_11	713586.KB900536_gene66	2.951e-12	72.0	COG3170@1|root,COG3170@2|Bacteria,1MXV7@1224|Proteobacteria,1RMM5@1236|Gammaproteobacteria,1WVVA@135613|Chromatiales	135613|Chromatiales	NU	FimV C-terminal	-	-	-	ko:K08086	-	-	-	-	ko00000	-	-	-	TPR_19
HKD1_k127_3182564_4	105559.Nwat_2013	3.391e-104	344.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,1RMK2@1236|Gammaproteobacteria,1WX2M@135613|Chromatiales	135613|Chromatiales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD1_k127_3182564_1	95619.PM1_0226155	3.431e-155	499.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,1RNS6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide	bioF	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iEC55989_1330.EC55989_0819,iECO111_1330.ECO111_0837,iECO26_1355.ECO26_0902,iSDY_1059.SDY_0830	Aminotran_1_2
HKD1_k127_3182564_2	1268237.G114_02039	9.623e-155	494.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,1RMEQ@1236|Gammaproteobacteria,1Y3GZ@135624|Aeromonadales	135624|Aeromonadales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_3182564_9	396588.Tgr7_0130	7.552e-31	126.0	2E1SU@1|root,32X2N@2|Bacteria,1N4HW@1224|Proteobacteria,1SAEX@1236|Gammaproteobacteria,1X167@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3182564_6	323261.Noc_2102	4.519e-70	246.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,1S64Q@1236|Gammaproteobacteria,1WWVF@135613|Chromatiales	135613|Chromatiales	S	Competence protein	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_3182564_0	1249627.D779_3007	7.136e-167	529.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,1WWB3@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD1_k127_3182564_5	472759.Nhal_0177	6.834e-72	248.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,1RMET@1236|Gammaproteobacteria,1WX5V@135613|Chromatiales	135613|Chromatiales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD1_k127_3182564_7	1187848.AJYQ01000066_gene3590	2.668e-54	195.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,1RQPJ@1236|Gammaproteobacteria,1XT73@135623|Vibrionales	135623|Vibrionales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	GO:0000725,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008821,GO:0009058,GO:0009059,GO:0009987,GO:0016787,GO:0016788,GO:0016889,GO:0016894,GO:0031297,GO:0032991,GO:0033554,GO:0034641,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0045005,GO:0046483,GO:0048476,GO:0050896,GO:0051716,GO:0071704,GO:0071932,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901576	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD1_k127_3182564_3	396588.Tgr7_2237	1.289e-112	369.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,1RP5N@1236|Gammaproteobacteria,1WX1Y@135613|Chromatiales	135613|Chromatiales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD1_k127_3182564_8	472759.Nhal_1452	1.458e-48	182.0	COG1075@1|root,COG1075@2|Bacteria,1N2W0@1224|Proteobacteria,1SAMR@1236|Gammaproteobacteria,1WZS4@135613|Chromatiales	135613|Chromatiales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_3182564_10	765911.Thivi_1912	2.503e-19	92.0	2ANKS@1|root,31DJZ@2|Bacteria,1R1SV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3221141_8	522306.CAP2UW1_1788	1.862e-75	261.0	COG1999@1|root,COG1999@2|Bacteria,1N6WC@1224|Proteobacteria,2VMIP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM electron transport protein SCO1 SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_3221141_4	522306.CAP2UW1_1324	2.56e-245	775.0	COG0543@1|root,COG1018@1|root,COG1290@1|root,COG0543@2|Bacteria,COG1018@2|Bacteria,COG1290@2|Bacteria,1MV72@1224|Proteobacteria,2VI6M@28216|Betaproteobacteria,1KR75@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome b(N-terminal)/b6/petB	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_B,FAD_binding_6,Fer2,NAD_binding_1
HKD1_k127_3221141_10	1454004.AW11_01051	5.96e-44	166.0	2CB7M@1|root,31H4T@2|Bacteria,1MYWT@1224|Proteobacteria,2VSTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3221141_5	596153.Alide_3614	8.045e-169	543.0	COG0843@1|root,COG0843@2|Bacteria,1QJ23@1224|Proteobacteria,2VKFW@28216|Betaproteobacteria,4AH9U@80864|Comamonadaceae	28216|Betaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	-	-	-	-	-	-	-	-	-	-	-	-	COX1
HKD1_k127_3221141_12	1123393.KB891316_gene1486	1.635e-17	85.0	COG0425@1|root,COG0425@2|Bacteria,1QU8C@1224|Proteobacteria,2WGIR@28216|Betaproteobacteria,1KTES@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Uncharacterized conserved protein (DUF2249)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2249
HKD1_k127_3221141_3	1267005.KB911266_gene1220	6.366e-292	923.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2TSXZ@28211|Alphaproteobacteria,3N7KV@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Major Facilitator Superfamily	MA20_17060	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD1_k127_3221141_13	1089551.KE386572_gene150	0.0002559	44.0	COG2223@1|root,COG2223@2|Bacteria,1MU27@1224|Proteobacteria,2TSXZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Major facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD1_k127_3221141_0	1255043.TVNIR_1752	0.0	2220.0	COG5013@1|root,COG5013@2|Bacteria,1MW9S@1224|Proteobacteria,1RQ27@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	-	1.7.5.1	ko:K00370	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Molybdopterin,Molydop_binding,Nitr_red_alph_N
HKD1_k127_3221141_2	1255043.TVNIR_1751	1.519e-296	914.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,1RNMJ@1236|Gammaproteobacteria,1X2P9@135613|Chromatiales	135613|Chromatiales	C	Respiratory nitrate reductase beta C-terminal	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
HKD1_k127_3221141_7	1255043.TVNIR_1750	6.495e-76	261.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,1RQ23@1236|Gammaproteobacteria,1X10H@135613|Chromatiales	135613|Chromatiales	C	Nitrate reductase delta subunit	-	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
HKD1_k127_3221141_6	697282.Mettu_3973	2.436e-87	293.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,1RPTD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
HKD1_k127_3221141_9	870187.Thini_4104	1.33e-44	166.0	COG0639@1|root,COG0639@2|Bacteria,1N2CE@1224|Proteobacteria,1S59R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HKD1_k127_3221141_11	555778.Hneap_0594	1.138e-39	154.0	COG2862@1|root,COG2862@2|Bacteria,1RANN@1224|Proteobacteria,1S2DE@1236|Gammaproteobacteria,1WY01@135613|Chromatiales	135613|Chromatiales	S	TIGRFAM TIGR00645 family protein	-	-	-	-	-	-	-	-	-	-	-	-	UPF0114
HKD1_k127_3221141_1	1005048.CFU_2022	0.0	1073.0	COG0403@1|root,COG1003@1|root,COG0403@2|Bacteria,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2VHQ6@28216|Betaproteobacteria,473IZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvP	-	1.4.4.2	ko:K00281	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD1_k127_3223474_2	765914.ThisiDRAFT_1998	1.133e-112	368.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_3223474_5	187272.Mlg_1980	8.65e-63	219.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,1S3UP@1236|Gammaproteobacteria,1WY5U@135613|Chromatiales	135613|Chromatiales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_3223474_4	1283300.ATXB01000001_gene1446	2.074e-84	287.0	COG0265@1|root,COG0265@2|Bacteria,1R9ZV@1224|Proteobacteria,1S2AZ@1236|Gammaproteobacteria,1XG38@135618|Methylococcales	135618|Methylococcales	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_3223474_9	1122169.AREN01000001_gene982	4.613e-16	81.0	COG5519@1|root,COG5519@2|Bacteria,1MW5H@1224|Proteobacteria,1RQ7H@1236|Gammaproteobacteria,1JE3F@118969|Legionellales	118969|Legionellales	L	Domain of unknown function (DUF927)	-	-	-	-	-	-	-	-	-	-	-	-	DUF927
HKD1_k127_3223474_8	1408444.JHYC01000013_gene2473	4.335e-17	82.0	2BNP9@1|root,32HCB@2|Bacteria,1QBYA@1224|Proteobacteria,1T7JI@1236|Gammaproteobacteria,1JFGD@118969|Legionellales	118969|Legionellales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3223474_0	287.DR97_3545	4.986e-218	701.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,1RMQI@1236|Gammaproteobacteria,1YD7A@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	GO:0000988,GO:0000990,GO:0003674,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016987,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031326,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0043254,GO:0044087,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901576,GO:1903506,GO:2000112,GO:2000142,GO:2001141	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_3223474_1	323261.Noc_0044	1.025e-165	539.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,1RMGA@1236|Gammaproteobacteria,1WX02@135613|Chromatiales	135613|Chromatiales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB_bind,DnaG_DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD1_k127_3223474_6	269482.Bcep1808_4262	4.299e-47	173.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2VR35@28216|Betaproteobacteria,1K70P@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_3223474_7	1517416.IDAT_09210	5.313e-31	122.0	COG0828@1|root,COG0828@2|Bacteria,1MZCC@1224|Proteobacteria,1S8QZ@1236|Gammaproteobacteria,2QGCD@267893|Idiomarinaceae	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_3223474_3	765911.Thivi_4080	2.412e-94	312.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales	135613|Chromatiales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_3226351_0	644966.Tmar_1834	1.497e-224	728.0	COG1743@1|root,COG1743@2|Bacteria,1TRIT@1239|Firmicutes,24AVX@186801|Clostridia	186801|Clostridia	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156,N6_N4_Mtase
HKD1_k127_3226351_2	1122139.KB907890_gene279	5.344e-27	113.0	COG2944@1|root,COG2944@2|Bacteria,1N5H0@1224|Proteobacteria,1SEZI@1236|Gammaproteobacteria,1XQW2@135619|Oceanospirillales	1236|Gammaproteobacteria	K	Antitoxin component of bacterial toxin-antitoxin system, MqsA	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3,HTH_31
HKD1_k127_3226351_1	870187.Thini_2237	6.013e-30	121.0	2E7RX@1|root,33276@2|Bacteria,1P206@1224|Proteobacteria,1SSHR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Uncharacterised protein family UPF0175	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
HKD1_k127_3226351_3	324925.Ppha_0275	5.686e-06	53.0	28JF1@1|root,2Z992@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3780)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3780
HKD1_k127_3230745_6	243365.CV_2191	4.918e-65	230.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2VKD4@28216|Betaproteobacteria,2KPKE@206351|Neisseriales	206351|Neisseriales	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_3230745_2	42565.FP66_10245	1.503e-118	389.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,1RN7F@1236|Gammaproteobacteria,1XHHX@135619|Oceanospirillales	135619|Oceanospirillales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_3230745_4	1049564.TevJSym_ai00190	3.205e-81	279.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,1RSE6@1236|Gammaproteobacteria,1J5AA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD1_k127_3230745_9	756067.MicvaDRAFT_3521	2.303e-18	86.0	COG4249@1|root,COG4249@2|Bacteria,1GA20@1117|Cyanobacteria,1HDDP@1150|Oscillatoriales	1117|Cyanobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
HKD1_k127_3230745_0	1123279.ATUS01000004_gene2902	0.0	1240.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,1RNCU@1236|Gammaproteobacteria,1J4G0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	GO:0000715,GO:0000716,GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006283,GO:0006289,GO:0006355,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008094,GO:0008150,GO:0008152,GO:0009889,GO:0009987,GO:0010468,GO:0010556,GO:0015616,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019219,GO:0019222,GO:0019899,GO:0031323,GO:0031326,GO:0033554,GO:0034641,GO:0042623,GO:0043170,GO:0043175,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051252,GO:0051276,GO:0051716,GO:0060255,GO:0065007,GO:0070063,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_3230745_7	76114.ebA3092	7.475e-31	127.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,2VJAN@28216|Betaproteobacteria,2KZN0@206389|Rhodocyclales	206389|Rhodocyclales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1
HKD1_k127_3230745_5	1121405.dsmv_0026	3.171e-71	243.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2MJZR@213118|Desulfobacterales	28221|Deltaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_3230745_3	572477.Alvin_2778	6.113e-97	326.0	COG5607@1|root,COG5607@2|Bacteria,1R5I1@1224|Proteobacteria,1S0QK@1236|Gammaproteobacteria,1WXTK@135613|Chromatiales	135613|Chromatiales	S	pfam chad	-	-	-	-	-	-	-	-	-	-	-	-	CHAD
HKD1_k127_3230745_1	1000565.METUNv1_02881	1.706e-168	534.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2VJD7@28216|Betaproteobacteria,2KVIA@206389|Rhodocyclales	206389|Rhodocyclales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_3230745_10	555778.Hneap_1348	1.294e-08	60.0	COG0546@1|root,COG0546@2|Bacteria,1RCXJ@1224|Proteobacteria,1S3VU@1236|Gammaproteobacteria,1WXXM@135613|Chromatiales	135613|Chromatiales	S	HAD-superfamily hydrolase, subfamily IA, variant 1	-	-	3.1.3.105	ko:K22292	ko00520,map00520	-	R11785	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_3230745_8	981336.F944_01181	1.653e-27	114.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMV7@1236|Gammaproteobacteria,3NKGB@468|Moraxellaceae	1236|Gammaproteobacteria	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	GO:0003674,GO:0003824,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008289,GO:0008689,GO:0008757,GO:0009058,GO:0009108,GO:0009628,GO:0009651,GO:0009987,GO:0016740,GO:0016741,GO:0032259,GO:0042180,GO:0042181,GO:0042538,GO:0043167,GO:0043168,GO:0043431,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0051188,GO:0061542,GO:0071704,GO:1901576,GO:1901611,GO:1901661,GO:1901663	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	iE2348C_1286.E2348C_2376	Methyltransf_23
HKD1_k127_3243063_6	937777.Deipe_0616	3.981e-73	278.0	COG0028@1|root,COG3055@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	3.2.1.4,4.1.3.1	ko:K01179,ko:K01637	ko00500,ko00630,ko01100,ko01110,ko01120,ko01200,map00500,map00630,map01100,map01110,map01120,map01200	M00012	R00479,R06200,R11307,R11308	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	GH5,GH9	-	Kelch_1,Laminin_G_3,Malectin,PKD,TIG
HKD1_k127_3243063_8	402777.KB235904_gene2680	2.527e-08	58.0	293VS@1|root,2ZRAY@2|Bacteria,1GFWP@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3243063_4	1343739.PAP_00225	1.706e-87	299.0	COG0697@1|root,arCOG00271@2157|Archaea,2XXKE@28890|Euryarchaeota,2434U@183968|Thermococci	183968|Thermococci	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3243063_1	1207063.P24_12497	9.646e-112	370.0	COG0697@1|root,COG0697@2|Bacteria,1MVGC@1224|Proteobacteria,2TS6Y@28211|Alphaproteobacteria,2JRDG@204441|Rhodospirillales	204441|Rhodospirillales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3243063_5	240016.ABIZ01000001_gene2057	5.455e-75	259.0	COG0475@1|root,COG0475@2|Bacteria,46VG1@74201|Verrucomicrobia,2IV6Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_3243063_3	349163.Acry_0356	9.015e-98	326.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2TR61@28211|Alphaproteobacteria,2JQ6B@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_3243063_2	1159870.KB907784_gene1910	6.8e-99	330.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VJM6@28216|Betaproteobacteria,3T22A@506|Alcaligenaceae	28216|Betaproteobacteria	E	ABC-type branched-chain amino acid transport systems ATPase component	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_3243063_0	349163.Acry_0358	6.822e-122	400.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2TSJQ@28211|Alphaproteobacteria,2JPM5@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
HKD1_k127_3243063_7	1408418.JNJH01000037_gene501	1.553e-20	91.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,2TSDS@28211|Alphaproteobacteria,2JQSZ@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_3297773_12	1238182.C882_2068	1.196e-58	204.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,2JPAS@204441|Rhodospirillales	204441|Rhodospirillales	P	transport system, permease component	-	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
HKD1_k127_3297773_0	1238182.C882_2069	8.462e-244	765.0	COG1123@1|root,COG4172@2|Bacteria,1MU09@1224|Proteobacteria,2TQP0@28211|Alphaproteobacteria,2JQ4Z@204441|Rhodospirillales	204441|Rhodospirillales	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K13896	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	ABC_tran,oligo_HPY
HKD1_k127_3297773_14	329726.AM1_4941	2.018e-34	134.0	COG3450@1|root,COG3450@2|Bacteria,1G7YR@1117|Cyanobacteria	1117|Cyanobacteria	S	of the cupin superfamily	-	-	-	ko:K06995	-	-	-	-	ko00000	-	-	-	Cupin_3
HKD1_k127_3297773_19	1185876.BN8_04548	1.618e-11	68.0	COG1082@1|root,COG1082@2|Bacteria,4NHXX@976|Bacteroidetes,47MGH@768503|Cytophagia	976|Bacteroidetes	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3297773_20	2340.JV46_22240	1.335e-10	64.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,1RMJP@1236|Gammaproteobacteria,1J4ZK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dusB	GO:0002943,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016491,GO:0016627,GO:0017150,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0050896,GO:0055114,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_3297773_18	745411.B3C1_02445	5.024e-21	99.0	COG2901@1|root,COG2901@2|Bacteria,1N7MJ@1224|Proteobacteria,1SD35@1236|Gammaproteobacteria,1J6UC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03557	ko05111,map05111	-	-	-	ko00000,ko00001,ko03000,ko03036,ko03400	-	-	-	HTH_8
HKD1_k127_3297773_17	713586.KB900536_gene1761	5.004e-23	100.0	COG1977@1|root,COG1977@2|Bacteria,1NHG7@1224|Proteobacteria,1TK6F@1236|Gammaproteobacteria,1WZUM@135613|Chromatiales	135613|Chromatiales	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	moaD	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_3297773_13	519989.ECTPHS_09408	5.26e-51	184.0	COG0314@1|root,COG0314@2|Bacteria,1RGUX@1224|Proteobacteria,1S5YH@1236|Gammaproteobacteria,1WYCE@135613|Chromatiales	135613|Chromatiales	H	PFAM molybdopterin biosynthesis MoaE	-	-	2.8.1.12	ko:K03635	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE
HKD1_k127_3297773_6	572477.Alvin_1282	4.349e-167	530.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,1RP9Z@1236|Gammaproteobacteria,1WWPU@135613|Chromatiales	135613|Chromatiales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_3297773_1	519989.ECTPHS_05591	2.642e-233	730.0	COG1190@1|root,COG1190@2|Bacteria,1MX1V@1224|Proteobacteria,1RMJN@1236|Gammaproteobacteria,1WVXY@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_3297773_10	1121935.AQXX01000130_gene2495	9.142e-134	433.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1RQ59@1236|Gammaproteobacteria,1XH6J@135619|Oceanospirillales	135619|Oceanospirillales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3,2.1.3.9	ko:K00611,ko:K09065	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01398,R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_3297773_16	118163.Ple7327_3260	5.553e-24	106.0	COG3437@1|root,COG3437@2|Bacteria	2|Bacteria	T	response regulator, receiver	rpfG	-	-	ko:K07814,ko:K13815	ko02020,ko02024,map02020,map02024	M00517	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HD,HD_5,Response_reg
HKD1_k127_3297773_15	713587.THITH_00435	6.08e-33	137.0	COG5473@1|root,COG5473@2|Bacteria,1R8RR@1224|Proteobacteria,1S395@1236|Gammaproteobacteria,1X27T@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3297773_11	713587.THITH_02140	1.888e-106	353.0	COG1526@1|root,COG1526@2|Bacteria,1MY28@1224|Proteobacteria,1RYH6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH	fdhD	-	-	ko:K02379	-	-	-	-	ko00000	-	-	-	FdhD-NarQ
HKD1_k127_3297773_3	1049564.TevJSym_av00430	8.805e-212	666.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,1RN1Y@1236|Gammaproteobacteria,1J4CI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016491,GO:0016627,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0051989,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.98.3	ko:K02495	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R06895	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI39_1322.ECIAI39_3134,iZ_1308.Z5403	HemN_C,Radical_SAM
HKD1_k127_3297773_4	1163617.SCD_n02443	6.702e-190	616.0	COG3850@1|root,COG5001@1|root,COG3850@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2VH3V@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE,EAL,GGDEF,PAS,PAS_3
HKD1_k127_3297773_2	472759.Nhal_2116	4.206e-220	694.0	COG0578@1|root,COG0578@2|Bacteria,1MUMY@1224|Proteobacteria,1RMGP@1236|Gammaproteobacteria,1WXTF@135613|Chromatiales	135613|Chromatiales	C	PFAM FAD dependent oxidoreductase	-	-	1.1.3.21,1.1.5.3	ko:K00105,ko:K00111	ko00564,ko01110,map00564,map01110	-	R00846,R00848	RC00029	ko00000,ko00001,ko01000	-	-	-	DAO,DAO_C
HKD1_k127_3297773_5	1123401.JHYQ01000003_gene2183	4.025e-174	556.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,45ZNA@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
HKD1_k127_3297773_7	1049564.TevJSym_aq00800	1.135e-159	513.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,1RMSU@1236|Gammaproteobacteria,1J53T@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	GO:0003674,GO:0003824,GO:0004774,GO:0004775,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0008150,GO:0008152,GO:0009060,GO:0009987,GO:0015980,GO:0016874,GO:0016877,GO:0016878,GO:0016999,GO:0017144,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0055114,GO:0071704,GO:0072350	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_3297773_9	187272.Mlg_2548	1.549e-152	486.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,1RM7Y@1236|Gammaproteobacteria,1WW8G@135613|Chromatiales	135613|Chromatiales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD1_k127_3297773_8	1380391.JIAS01000011_gene5100	1.001e-153	501.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,2JQSN@204441|Rhodospirillales	204441|Rhodospirillales	M	Penicillin-Binding Protein C-terminus Family	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HKD1_k127_333852_4	1249634.D781_4388	4.955e-58	210.0	COG0742@1|root,COG0742@2|Bacteria,1MX8Z@1224|Proteobacteria,1RMIB@1236|Gammaproteobacteria,400SI@613|Serratia	1236|Gammaproteobacteria	J	Specifically methylates the guanosine in position 1516 of 16S rRNA	rsmJ	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036308,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.242	ko:K15984	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SAM_MT
HKD1_k127_333852_3	909663.KI867150_gene2575	6.14e-128	421.0	COG2271@1|root,COG2271@2|Bacteria,1QYDE@1224|Proteobacteria,43CG4@68525|delta/epsilon subdivisions,2X7R5@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HKD1_k127_333852_1	713586.KB900536_gene725	7.535e-320	990.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,1RN6Z@1236|Gammaproteobacteria,1WW4U@135613|Chromatiales	135613|Chromatiales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_333852_2	1122201.AUAZ01000018_gene1671	1.395e-168	539.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,1RNN0@1236|Gammaproteobacteria,467I6@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	aspC	-	2.6.1.1,2.6.1.84	ko:K00812,ko:K12252	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052,R08197	RC00006,RC00008	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_333852_7	1205680.CAKO01000023_gene4511	3.057e-05	56.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_333852_6	1121447.JONL01000001_gene735	5.069e-06	48.0	2EG8N@1|root,33A0G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_333852_0	1120999.JONM01000006_gene2394	0.0	1511.0	COG4733@1|root,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBM_20,CBM_25,PKD,fn3
HKD1_k127_333852_5	1088721.NSU_0816	6.83e-12	80.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_3349122_3	1121033.AUCF01000032_gene2634	1.843e-117	383.0	COG0119@1|root,COG0119@2|Bacteria,1MUMX@1224|Proteobacteria,2TT1R@28211|Alphaproteobacteria,2JPU7@204441|Rhodospirillales	204441|Rhodospirillales	E	COG0119 Isopropylmalate homocitrate citramalate synthases	-	-	4.1.3.4	ko:K01640	ko00072,ko00280,ko00281,ko00650,ko01100,ko04146,map00072,map00280,map00281,map00650,map01100,map04146	M00036,M00088	R01360,R08090	RC00502,RC00503,RC01118,RC01946	ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_3349122_5	247639.MGP2080_02146	1.583e-103	346.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
HKD1_k127_3349122_1	935863.AWZR01000003_gene2764	6.427e-207	651.0	COG2723@1|root,COG2723@2|Bacteria,1MWG6@1224|Proteobacteria,1RMM2@1236|Gammaproteobacteria,1X3QG@135614|Xanthomonadales	135614|Xanthomonadales	G	COG2723 Beta-glucosidase 6-phospho-beta-glucosidase beta- galactosidase	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD1_k127_3349122_9	85643.Tmz1t_0730	1.096e-46	173.0	COG2050@1|root,COG2050@2|Bacteria,1RGVD@1224|Proteobacteria,2VRED@28216|Betaproteobacteria,2KYNZ@206389|Rhodocyclales	206389|Rhodocyclales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_3349122_6	1185876.BN8_01769	5.281e-90	312.0	COG0318@1|root,COG0318@2|Bacteria,4NEXK@976|Bacteroidetes,47KUG@768503|Cytophagia	976|Bacteroidetes	IQ	Acyl-CoA synthetase (AMP-forming) AMP-acid ligase II	menE	-	6.2.1.26	ko:K01911	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04030	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_3349122_7	56110.Oscil6304_3032	5.267e-87	292.0	COG4636@1|root,COG4636@2|Bacteria,1FZYR@1117|Cyanobacteria,1H7TI@1150|Oscillatoriales	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_3349122_0	323261.Noc_1826	1.982e-294	918.0	COG3408@1|root,COG3408@2|Bacteria,1MW01@1224|Proteobacteria,1RZPU@1236|Gammaproteobacteria,1WW3K@135613|Chromatiales	135613|Chromatiales	G	PFAM Amylo-alpha-16-glucosidase	-	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	GDE_C,GDE_N
HKD1_k127_3349122_8	63737.Npun_F3106	1.751e-73	265.0	COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria,1HRZQ@1161|Nostocales	1117|Cyanobacteria	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3349122_10	768710.DesyoDRAFT_2480	1.646e-11	69.0	COG1943@1|root,COG1943@2|Bacteria,1V1CM@1239|Firmicutes,24BK2@186801|Clostridia,262Y3@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_3349122_4	697282.Mettu_2210	7.506e-113	374.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,1SMMC@1236|Gammaproteobacteria,1XG20@135618|Methylococcales	135618|Methylococcales	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD1_k127_3349122_2	697282.Mettu_2209	6.153e-161	511.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1XG1Z@135618|Methylococcales	135618|Methylococcales	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
HKD1_k127_3354194_3	472759.Nhal_3004	1.958e-34	137.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,1RP3U@1236|Gammaproteobacteria,1WZUN@135613|Chromatiales	135613|Chromatiales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_3354194_0	768671.ThimaDRAFT_0421	6.266e-188	601.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,1RQA2@1236|Gammaproteobacteria,1WYPQ@135613|Chromatiales	135613|Chromatiales	L	PFAM Integrase catalytic	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_3354194_4	768671.ThimaDRAFT_1930	6.134e-21	96.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,1WYTC@135613|Chromatiales	135613|Chromatiales	L	ATP binding N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
HKD1_k127_3354194_2	1121937.AUHJ01000042_gene290	7.201e-54	192.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,1RNUA@1236|Gammaproteobacteria,4679W@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	istB3	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21,IstB_IS21_ATP
HKD1_k127_3354194_1	1131553.JIBI01000008_gene1287	4.894e-59	222.0	COG0582@1|root,COG3206@1|root,COG0582@2|Bacteria,COG3206@2|Bacteria,1NRKW@1224|Proteobacteria,2VR08@28216|Betaproteobacteria,371Q0@32003|Nitrosomonadales	28216|Betaproteobacteria	LM	viral genome integration into host DNA	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_3384032_2	472759.Nhal_3572	5.326e-39	149.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,1RQU0@1236|Gammaproteobacteria,1WW93@135613|Chromatiales	135613|Chromatiales	J	Belongs to the pseudouridine synthase RsuA family	-	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_3384032_0	395493.BegalDRAFT_3110	1.921e-99	330.0	COG1028@1|root,COG1028@2|Bacteria,1MWBC@1224|Proteobacteria,1RNNV@1236|Gammaproteobacteria,460UW@72273|Thiotrichales	72273|Thiotrichales	IQ	short-chain dehydrogenase reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_3384032_1	713586.KB900536_gene1899	1.857e-79	268.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD1_k127_338906_12	743719.PaelaDRAFT_5486	1.841e-13	72.0	COG0366@1|root,COG0737@1|root,COG2374@1|root,COG0366@2|Bacteria,COG0737@2|Bacteria,COG2374@2|Bacteria,1TPV2@1239|Firmicutes,4H9VJ@91061|Bacilli,2776J@186822|Paenibacillaceae	91061|Bacilli	F	5'-nucleotidase, C-terminal domain	cpdB	-	3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45	ko:K01081,ko:K07004,ko:K08693,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,CHB_HEX_C_1,Gram_pos_anchor,LTD,Metallophos,SLH
HKD1_k127_338906_10	118168.MC7420_3010	6.264e-35	139.0	COG0639@1|root,COG0639@2|Bacteria,1GQ13@1117|Cyanobacteria,1HB32@1150|Oscillatoriales	1117|Cyanobacteria	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HKD1_k127_338906_9	1096546.WYO_2811	5.865e-43	160.0	COG2337@1|root,COG2337@2|Bacteria,1MZAV@1224|Proteobacteria,2UD15@28211|Alphaproteobacteria,1JVYU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_338906_11	1096546.WYO_2810	1.253e-16	81.0	2AE6K@1|root,3140E@2|Bacteria,1PTCN@1224|Proteobacteria,2V58N@28211|Alphaproteobacteria,1JW6A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein  of unknown function (DUF3018)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3018
HKD1_k127_338906_2	1528106.JRJE01000030_gene259	2.491e-175	558.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,2JPBU@204441|Rhodospirillales	204441|Rhodospirillales	I	de-polymerase	-	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
HKD1_k127_338906_7	287.DR97_2315	1.666e-50	187.0	COG1988@1|root,COG1988@2|Bacteria,1RBHW@1224|Proteobacteria,1S2F9@1236|Gammaproteobacteria,1YGC1@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	ybcI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD1_k127_338906_4	1316936.K678_08399	5.616e-78	271.0	COG4973@1|root,COG4973@2|Bacteria,1MUJJ@1224|Proteobacteria,2TVZJ@28211|Alphaproteobacteria,2JYV0@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the 'phage' integrase family. XerC subfamily	xerC	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_338906_5	317619.ANKN01000111_gene1546	1.647e-68	238.0	298Z8@1|root,2ZAUN@2|Bacteria,1G3DP@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_338906_1	396588.Tgr7_0275	3.672e-250	792.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,1RPZ7@1236|Gammaproteobacteria,1WX60@135613|Chromatiales	135613|Chromatiales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_338906_3	686340.Metal_3283	2.63e-104	343.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,1RP7X@1236|Gammaproteobacteria,1XDJM@135618|Methylococcales	135618|Methylococcales	C	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_338906_14	1267600.JFGT01000005_gene2662	1.791e-06	54.0	COG2823@1|root,COG2823@2|Bacteria,1PCIJ@1224|Proteobacteria,1RRGP@1236|Gammaproteobacteria,3VZYT@53335|Pantoea	1236|Gammaproteobacteria	S	periplasmic	osmY	GO:0005575,GO:0005623,GO:0006457,GO:0006950,GO:0006970,GO:0006972,GO:0008150,GO:0009628,GO:0009987,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0044464,GO:0050896,GO:0061077	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON
HKD1_k127_338906_0	713586.KB900536_gene1253	7.863e-272	848.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria,1WWE5@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_338906_8	395493.BegalDRAFT_3149	1.852e-49	180.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,1S640@1236|Gammaproteobacteria,460ZB@72273|Thiotrichales	72273|Thiotrichales	C	Belongs to the glutaredoxin family. Monothiol subfamily	-	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
HKD1_k127_338906_6	1049564.TevJSym_an00750	8.383e-67	230.0	COG0847@1|root,COG0847@2|Bacteria,1MUPK@1224|Proteobacteria,1RMMH@1236|Gammaproteobacteria,1J5U7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Trims short 3' overhangs of a variety of RNA species, leaving a one or two nucleotide 3' overhang. Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis	rnt	GO:0000287,GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004540,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008408,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0031123,GO:0034470,GO:0034641,GO:0034660,GO:0042780,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043628,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0140098,GO:1901360	-	ko:K03683	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_T
HKD1_k127_3404535_2	395493.BegalDRAFT_0824	1.045e-29	123.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,45ZST@72273|Thiotrichales	1236|Gammaproteobacteria	H	MoeA N-terminal region (domain I and II)	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MobB,MoeA_C,MoeA_N
HKD1_k127_3404535_1	1278073.MYSTI_05459	7.57e-42	164.0	COG1651@1|root,COG1651@2|Bacteria,1MX2T@1224|Proteobacteria,42S4E@68525|delta/epsilon subdivisions,2WNJ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3,Thioredoxin_4
HKD1_k127_3404535_0	420324.KI912086_gene7338	1.093e-133	436.0	COG2124@1|root,COG2124@2|Bacteria,1MV75@1224|Proteobacteria,2TSV7@28211|Alphaproteobacteria,1JXGU@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	Cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_3409738_0	443598.AUFA01000010_gene375	7.366e-191	601.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2TRXF@28211|Alphaproteobacteria,3JSVF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	TIGRFAM chromate transporter, chromate ion transporter (CHR) family	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_3409738_1	323261.Noc_2697	4.624e-140	452.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,1RPPQ@1236|Gammaproteobacteria,1WX09@135613|Chromatiales	135613|Chromatiales	P	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C
HKD1_k127_3409738_2	243233.MCA0408	9.096e-53	196.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,1SB83@1236|Gammaproteobacteria,1XGK1@135618|Methylococcales	135618|Methylococcales	S	Predicted periplasmic protein (DUF2092)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD1_k127_3409738_4	663610.JQKO01000002_gene1260	2.783e-07	61.0	2E8Y7@1|root,3337X@2|Bacteria,1NBJG@1224|Proteobacteria,2UW7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3409738_3	1035191.HMPREF0185_01905	1.914e-25	116.0	COG2067@1|root,COG2067@2|Bacteria,1RBTA@1224|Proteobacteria,2VGDN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3413952_2	443143.GM18_0163	2.112e-65	232.0	COG1232@1|root,COG1232@2|Bacteria,1R5SZ@1224|Proteobacteria,42YX0@68525|delta/epsilon subdivisions,2WTXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Flavin containing amine oxidoreductase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD1_k127_3413952_3	443152.MDG893_07665	2.389e-53	196.0	COG1309@1|root,COG1309@2|Bacteria,1RCC8@1224|Proteobacteria,1SG0S@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_3413952_0	443143.GM18_4468	2.165e-190	623.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WJCX@28221|Deltaproteobacteria,43SZR@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,HAMP,HATPase_c,HisKA,Hpt,Response_reg
HKD1_k127_3413952_4	765912.Thimo_0530	1.805e-49	182.0	COG0394@1|root,COG0394@2|Bacteria,1RH90@1224|Proteobacteria,1S5X6@1236|Gammaproteobacteria,1WY50@135613|Chromatiales	135613|Chromatiales	T	low molecular weight	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_3413952_1	1111732.AZOD01000024_gene1933	5.621e-71	255.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,1RMP1@1236|Gammaproteobacteria,1X3FV@135614|Xanthomonadales	135614|Xanthomonadales	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,LysM
HKD1_k127_3413952_5	1049564.TevJSym_bl00240	3.872e-22	97.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,1S6IB@1236|Gammaproteobacteria,1J65S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	ATPase or kinase	yjeE	GO:0000166,GO:0002949,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034470,GO:0034641,GO:0034660,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043531,GO:0044237,GO:0044238,GO:0046483,GO:0070525,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD1_k127_3429601_16	522306.CAP2UW1_0060	3.382e-111	366.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2W186@28216|Betaproteobacteria	28216|Betaproteobacteria	FP	Ppx/GppA phosphatase family	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD1_k127_3429601_20	557598.LHK_02958	6.745e-59	209.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2VRDN@28216|Betaproteobacteria,2KR45@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD1_k127_3429601_13	1255043.TVNIR_3467	7.044e-120	416.0	COG2374@1|root,COG4932@1|root,COG2374@2|Bacteria,COG4932@2|Bacteria,1QW47@1224|Proteobacteria,1RQU1@1236|Gammaproteobacteria,1X2PQ@135613|Chromatiales	135613|Chromatiales	M	Endonuclease Exonuclease Phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3429601_30	2002.JOEQ01000010_gene6368	1.587e-19	104.0	COG1361@1|root,COG3468@1|root,COG4719@1|root,COG4733@1|root,COG1361@2|Bacteria,COG3468@2|Bacteria,COG4719@2|Bacteria,COG4733@2|Bacteria,2I8F1@201174|Actinobacteria,4EKYK@85012|Streptosporangiales	201174|Actinobacteria	M	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,He_PIG,fn3
HKD1_k127_3429601_6	519989.ECTPHS_06482	4.385e-195	632.0	COG4796@1|root,COG4796@2|Bacteria,1QTT6@1224|Proteobacteria,1RN3Z@1236|Gammaproteobacteria,1WWYN@135613|Chromatiales	135613|Chromatiales	U	type IV pilus secretin PilQ	-	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
HKD1_k127_3429601_27	1049564.TevJSym_bb00170	6.679e-35	141.0	COG3168@1|root,COG3168@2|Bacteria,1RI6V@1224|Proteobacteria,1S6VJ@1236|Gammaproteobacteria,1J6N8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	COG3168 Tfp pilus assembly protein PilP	pilP	-	-	ko:K02665	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilP
HKD1_k127_3429601_24	1049564.TevJSym_bb00160	3.004e-50	187.0	COG3167@1|root,COG3167@2|Bacteria,1RBGW@1224|Proteobacteria,1S3XQ@1236|Gammaproteobacteria,1J6DF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Pilus assembly protein, PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD1_k127_3429601_25	631362.Thi970DRAFT_01005	2.478e-39	154.0	COG3166@1|root,COG3166@2|Bacteria,1RF1S@1224|Proteobacteria,1S3S0@1236|Gammaproteobacteria,1WY4Z@135613|Chromatiales	135613|Chromatiales	NU	PFAM Fimbrial assembly	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD1_k127_3429601_18	396588.Tgr7_3023	4.607e-86	297.0	COG4972@1|root,COG4972@2|Bacteria,1MX8P@1224|Proteobacteria,1RN8S@1236|Gammaproteobacteria,1WXGR@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV pilus assembly protein PilM	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD1_k127_3429601_21	187272.Mlg_2753	7.444e-58	208.0	COG1418@1|root,COG1418@2|Bacteria,1RH6M@1224|Proteobacteria,1S81F@1236|Gammaproteobacteria,1X2NE@135613|Chromatiales	135613|Chromatiales	S	mRNA catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3429601_5	1111732.AZOD01000004_gene1017	3.674e-204	642.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,1RNDK@1236|Gammaproteobacteria,1X3KV@135614|Xanthomonadales	135614|Xanthomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_3429601_26	265072.Mfla_2291	4.416e-39	146.0	COG0254@1|root,COG0254@2|Bacteria,1MZ4D@1224|Proteobacteria,2VU3I@28216|Betaproteobacteria,2KN4F@206350|Nitrosomonadales	206350|Nitrosomonadales	J	PFAM ribosomal protein L31	rpmE2	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD1_k127_3429601_10	713586.KB900536_gene1556	7.723e-162	522.0	COG0548@1|root,COG1246@1|root,COG0548@2|Bacteria,COG1246@2|Bacteria,1MUUP@1224|Proteobacteria,1RMV5@1236|Gammaproteobacteria,1WX9B@135613|Chromatiales	135613|Chromatiales	E	Belongs to the acetyltransferase family. ArgA subfamily	argA	-	2.3.1.1	ko:K14682	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,Acetyltransf_1
HKD1_k127_3429601_9	472759.Nhal_0011	1.101e-163	523.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,1RNFF@1236|Gammaproteobacteria,1WXJM@135613|Chromatiales	135613|Chromatiales	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11	ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HKD1_k127_3429601_11	314278.NB231_01219	1.44e-151	489.0	COG3954@1|root,COG3954@2|Bacteria,1MWN9@1224|Proteobacteria,1RMS7@1236|Gammaproteobacteria,1WWCG@135613|Chromatiales	135613|Chromatiales	C	PFAM Phosphoribulokinase uridine kinase	-	-	2.7.1.19	ko:K00855	ko00710,ko01100,ko01120,ko01200,map00710,map01100,map01120,map01200	M00165,M00166	R01523	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PRK
HKD1_k127_3429601_1	395493.BegalDRAFT_1910	1.71e-264	828.0	COG0517@1|root,COG0538@1|root,COG0517@2|Bacteria,COG0538@2|Bacteria,1MW3J@1224|Proteobacteria,1RNMD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Isocitrate dehydrogenase	icd	GO:0003674,GO:0003824,GO:0004448,GO:0004450,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006091,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0022900,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0055114	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	e_coli_core.b1136,iAF1260.b1136,iECDH1ME8569_1439.ECDH1ME8569_1071,iEcDH1_1363.EcDH1_2511,iJN746.PP_4011,iJO1366.b1136,iJR904.b1136,iY75_1357.Y75_RS05930,iYL1228.KPN_01144	Iso_dh
HKD1_k127_3429601_14	1163617.SCD_n02166	3.735e-113	376.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2VIBJ@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	oxyR	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_3429601_3	1380394.JADL01000011_gene3804	2.39e-240	750.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JPSC@204441|Rhodospirillales	204441|Rhodospirillales	C	belongs to the aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_3429601_28	1125863.JAFN01000001_gene2740	7.193e-33	133.0	COG0589@1|root,COG0589@2|Bacteria,1N9QR@1224|Proteobacteria,42X66@68525|delta/epsilon subdivisions,2WSWA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3429601_29	768671.ThimaDRAFT_3916	1.101e-26	116.0	2E45W@1|root,32SZG@2|Bacteria,1MZSG@1224|Proteobacteria,1S9BI@1236|Gammaproteobacteria,1WZ2A@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3429601_15	1121405.dsmv_1334	1.176e-111	364.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,42PNX@68525|delta/epsilon subdivisions,2WK8F@28221|Deltaproteobacteria,2MJU9@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Cysteine-rich domain	-	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
HKD1_k127_3429601_4	207559.Dde_1843	3.776e-224	704.0	COG1139@1|root,COG1139@2|Bacteria,1MV6J@1224|Proteobacteria,42MN2@68525|delta/epsilon subdivisions,2WIMJ@28221|Deltaproteobacteria,2M80P@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_8,LUD_dom
HKD1_k127_3429601_22	225937.HP15_2888	5.179e-56	205.0	COG1556@1|root,COG1556@2|Bacteria,1RJ6A@1224|Proteobacteria,1S7WZ@1236|Gammaproteobacteria,4694P@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	LUD domain	ykgG	-	-	ko:K00782	-	-	-	-	ko00000	-	-	iECO111_1330.ECO111_0342,iECO26_1355.ECO26_0342	LUD_dom
HKD1_k127_3429601_0	713587.THITH_06930	0.0	1249.0	COG0247@1|root,COG0277@1|root,COG1146@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,COG1146@2|Bacteria,1MU6Y@1224|Proteobacteria,1RM7Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S ferredoxin	lldE	-	-	ko:K18930	-	-	-	-	ko00000	-	-	-	CCG,FAD-oxidase_C,FAD_binding_4,Fer4_7,Fer4_8
HKD1_k127_3429601_17	1207076.ALAT01000099_gene2345	7.328e-108	360.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,1RR44@1236|Gammaproteobacteria,1Z16P@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Histidine-specific methyltransferase, SAM-dependent	egtD	-	2.1.1.44	ko:K18911	ko00340,map00340	-	R01169	RC00003,RC02308	ko00000,ko00001,ko01000	-	-	-	Methyltransf_33
HKD1_k127_3429601_8	1123368.AUIS01000007_gene2806	5.993e-183	581.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,1RQI4@1236|Gammaproteobacteria,2NBZX@225057|Acidithiobacillales	225057|Acidithiobacillales	H	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase,Methyltransf_31
HKD1_k127_3429601_2	243233.MCA2059	2.849e-252	788.0	COG0155@1|root,COG0155@2|Bacteria,1MVVB@1224|Proteobacteria,1RMFH@1236|Gammaproteobacteria,1XEB1@135618|Methylococcales	135618|Methylococcales	C	reductase 4Fe-4S	-	-	1.8.1.2	ko:K00381	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R00858	RC00065	ko00000,ko00001,ko00002,ko01000	-	-	-	NIR_SIR,NIR_SIR_ferr
HKD1_k127_3429601_23	1218074.BAXZ01000012_gene2912	5.05e-54	194.0	COG3749@1|root,COG3749@2|Bacteria,1RJR9@1224|Proteobacteria,2VSQB@28216|Betaproteobacteria,1K41U@119060|Burkholderiaceae	28216|Betaproteobacteria	S	conserved protein ucp030820	-	-	-	-	-	-	-	-	-	-	-	-	DUF934
HKD1_k127_3429601_19	269799.Gmet_1137	3.219e-69	246.0	COG3500@1|root,COG3500@2|Bacteria,1QK0F@1224|Proteobacteria,42T0N@68525|delta/epsilon subdivisions,2WPW1@28221|Deltaproteobacteria,43VVG@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Late control gene D protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3429601_7	265072.Mfla_0652	1.95e-187	596.0	COG0007@1|root,COG1648@1|root,COG0007@2|Bacteria,COG1648@2|Bacteria,1MUI0@1224|Proteobacteria,2VICS@28216|Betaproteobacteria,2KKMV@206350|Nitrosomonadales	206350|Nitrosomonadales	H	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme	cysG	-	1.3.1.76,2.1.1.107,4.99.1.4	ko:K02302	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03194,R03947	RC00003,RC00871,RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	CysG_dimeriser,NAD_binding_7,Sirohm_synth_M,TP_methylase
HKD1_k127_3429601_12	1268635.Loa_02269	1.389e-150	487.0	COG5008@1|root,COG5008@2|Bacteria,1QTTX@1224|Proteobacteria,1RN0B@1236|Gammaproteobacteria,1JCV7@118969|Legionellales	118969|Legionellales	NU	Type II/IV secretion system protein	uptC	-	-	ko:K02670	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_3458344_3	1163617.SCD_n01425	1.263e-39	152.0	2CM31@1|root,32SD0@2|Bacteria,1N2TZ@1224|Proteobacteria,2VUNK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3458344_1	1095769.CAHF01000013_gene3217	4.237e-88	295.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,473GA@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Haemolysin-III related	hlyIII	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD1_k127_3458344_0	261292.Nit79A3_3412	6.204e-132	432.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2VJ75@28216|Betaproteobacteria,3722T@32003|Nitrosomonadales	28216|Betaproteobacteria	P	NnrS protein	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD1_k127_3458344_2	1366050.N234_10140	1.711e-70	253.0	COG1680@1|root,COG2815@1|root,COG1680@2|Bacteria,COG2815@2|Bacteria,1RIP7@1224|Proteobacteria,2W73Q@28216|Betaproteobacteria,1KDQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	V	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_3460941_5	1111732.AZOD01000016_gene215	4.63e-58	207.0	COG0634@1|root,COG0634@2|Bacteria,1NRT8@1224|Proteobacteria,1RNPQ@1236|Gammaproteobacteria,1X3NG@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the salvage synthesis of inosine-5'-monophosphate (IMP) and guanosine-5'-monophosphate (GMP) from the purine bases hypoxanthine and guanine, respectively	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD1_k127_3460941_1	472759.Nhal_2858	2.944e-125	411.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,1RMQF@1236|Gammaproteobacteria,1WXR0@135613|Chromatiales	135613|Chromatiales	G	Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide-linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N-acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD1_k127_3460941_7	439235.Dalk_1071	8.66e-29	121.0	COG2204@1|root,COG2204@2|Bacteria,1NBTR@1224|Proteobacteria,42V7Q@68525|delta/epsilon subdivisions,2WR8M@28221|Deltaproteobacteria,2MM1C@213118|Desulfobacterales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_3460941_2	1168065.DOK_16228	2.826e-111	372.0	COG0745@1|root,COG2208@1|root,COG0745@2|Bacteria,COG2208@2|Bacteria,1R3UE@1224|Proteobacteria,1RRJX@1236|Gammaproteobacteria,1JC15@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	KT	COG0784 FOG CheY-like receiver	rssB	GO:0000988,GO:0000989,GO:0003674,GO:0008150,GO:0009889,GO:0009893,GO:0010556,GO:0010604,GO:0016989,GO:0019219,GO:0019222,GO:0030162,GO:0031323,GO:0031325,GO:0031326,GO:0031647,GO:0031648,GO:0032268,GO:0032270,GO:0045862,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051252,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:0140110,GO:1903506,GO:2001141	-	ko:K02485	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,SpoIIE
HKD1_k127_3460941_8	1265490.JHVY01000002_gene3356	1.006e-26	115.0	COG1366@1|root,COG1366@2|Bacteria,1RIIT@1224|Proteobacteria,1S4RH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Anti-anti-sigma regulatory factor (Antagonist of anti-sigma factor)	-	-	-	-	-	-	-	-	-	-	-	-	STAS
HKD1_k127_3460941_3	631362.Thi970DRAFT_01369	1.853e-61	216.0	COG1376@1|root,COG1376@2|Bacteria,1RHBG@1224|Proteobacteria,1S6DY@1236|Gammaproteobacteria,1X25T@135613|Chromatiales	135613|Chromatiales	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_3460941_4	857087.Metme_0240	4.744e-60	211.0	COG2954@1|root,COG2954@2|Bacteria,1RI38@1224|Proteobacteria,1S77V@1236|Gammaproteobacteria,1XF52@135618|Methylococcales	135618|Methylococcales	S	CYTH	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CYTH
HKD1_k127_3460941_9	756067.MicvaDRAFT_0829	0.0005136	48.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG3322@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,COG3322@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria,1H82F@1150|Oscillatoriales	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,GAF,GAF_3,HAMP,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_3460941_6	1122197.ATWI01000011_gene191	3.209e-57	207.0	COG3897@1|root,COG3897@2|Bacteria,1N9VC@1224|Proteobacteria,1S3YF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PrmA
HKD1_k127_3460941_0	1123368.AUIS01000008_gene2246	1.658e-140	467.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_3474256_3	870187.Thini_0211	4.307e-30	124.0	COG1518@1|root,COG1518@2|Bacteria,1MUKK@1224|Proteobacteria,1S1H3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette	-	-	-	ko:K15342	-	-	-	-	ko00000,ko02048,ko03400	-	-	-	Cas_Cas1
HKD1_k127_3474256_5	713587.THITH_05210	1.909e-29	124.0	COG1468@1|root,COG1468@2|Bacteria,1RGP6@1224|Proteobacteria,1S5SN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Domain of unknown function DUF83	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Cas_Cas4
HKD1_k127_3474256_4	1123400.KB904791_gene116	5.06e-30	128.0	28PU8@1|root,2ZCF8@2|Bacteria,1RBYM@1224|Proteobacteria,1S27N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3474256_0	1123400.KB904791_gene115	2.366e-55	207.0	28JV4@1|root,2Z9K2@2|Bacteria,1R79T@1224|Proteobacteria,1RS5W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	CRISPR-associated protein Csc2	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3474256_7	1122218.KB893653_gene1543	2.662e-05	58.0	2BWNK@1|root,2Z8S4@2|Bacteria,1R65F@1224|Proteobacteria	1224|Proteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3474256_6	472759.Nhal_2922	5.255e-18	93.0	COG1583@1|root,COG1583@2|Bacteria,1RBSD@1224|Proteobacteria,1S3CG@1236|Gammaproteobacteria,1WZXC@135613|Chromatiales	135613|Chromatiales	L	CRISPR associated protein Cas6	-	-	-	-	-	-	-	-	-	-	-	-	Cas_Cas6
HKD1_k127_3474256_2	765914.ThisiDRAFT_2262	4.459e-45	184.0	COG1203@1|root,COG1203@2|Bacteria,1NGH8@1224|Proteobacteria,1RSFH@1236|Gammaproteobacteria,1WZVX@135613|Chromatiales	135613|Chromatiales	L	DEAD-like helicases superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DEAD
HKD1_k127_3474256_1	32057.KB217478_gene2481	1.146e-46	170.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HNK2@1161|Nostocales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
HKD1_k127_3485001_0	323261.Noc_1583	0.0	1752.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1X0D0@135613|Chromatiales	135613|Chromatiales	CEH	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_3485001_1	1121374.KB891592_gene2939	1.674e-143	476.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,Protoglobin,Response_reg
HKD1_k127_3485001_2	391612.CY0110_05017	1.399e-46	189.0	COG5000@1|root,COG5000@2|Bacteria,1GQW1@1117|Cyanobacteria	1117|Cyanobacteria	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD1_k127_3485001_3	1268622.AVS7_02815	1.36e-29	134.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2VIFS@28216|Betaproteobacteria,4A9PZ@80864|Comamonadaceae	28216|Betaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_35064_6	472759.Nhal_3985	1.835e-09	58.0	COG1662@1|root,COG1662@2|Bacteria,1NFF1@1224|Proteobacteria,1SEGH@1236|Gammaproteobacteria,1WZDG@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1
HKD1_k127_35064_1	1005395.CSV86_04342	2.34e-124	408.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,1RN2A@1236|Gammaproteobacteria,1YWQN@136845|Pseudomonas putida group	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	GO:0001505,GO:0003674,GO:0003824,GO:0004047,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0016740,GO:0016741,GO:0017144,GO:0019464,GO:0019752,GO:0032259,GO:0042133,GO:0042135,GO:0042737,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	iSFV_1184.SFV_2953	GCV_T,GCV_T_C
HKD1_k127_35064_4	637910.ROD_49291	1.274e-44	165.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,1S656@1236|Gammaproteobacteria,3WY8F@544|Citrobacter	1236|Gammaproteobacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	GO:0001505,GO:0003674,GO:0005488,GO:0005504,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006544,GO:0006546,GO:0006807,GO:0008150,GO:0008152,GO:0008289,GO:0009056,GO:0009063,GO:0009069,GO:0009071,GO:0009987,GO:0016054,GO:0017144,GO:0019464,GO:0019752,GO:0031405,GO:0031406,GO:0033293,GO:0036094,GO:0042133,GO:0042135,GO:0042737,GO:0043167,GO:0043168,GO:0043177,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046395,GO:0048037,GO:0050662,GO:0065007,GO:0065008,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606,GO:1901681	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	iE2348C_1286.E2348C_3156,iPC815.YPO0906	GCV_H
HKD1_k127_35064_2	1198232.CYCME_0484	3.967e-69	238.0	COG2077@1|root,COG2077@2|Bacteria,1RAJ9@1224|Proteobacteria,1S263@1236|Gammaproteobacteria,460M2@72273|Thiotrichales	72273|Thiotrichales	O	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides	tpx	-	1.11.1.15	ko:K11065	-	-	-	-	ko00000,ko01000	-	-	-	Redoxin
HKD1_k127_35064_5	396588.Tgr7_2754	2.364e-39	149.0	COG0818@1|root,COG0818@2|Bacteria,1MZ3Q@1224|Proteobacteria,1S92I@1236|Gammaproteobacteria,1WYCK@135613|Chromatiales	135613|Chromatiales	M	Recycling of diacylglycerol produced during the turnover of membrane phospholipid	-	-	2.7.1.107	ko:K00901	ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
HKD1_k127_35064_0	243233.MCA0047	9.665e-135	436.0	COG0524@1|root,COG0524@2|Bacteria,1QTMS@1224|Proteobacteria,1RQQY@1236|Gammaproteobacteria,1XDKQ@135618|Methylococcales	135618|Methylococcales	G	pfkB family carbohydrate kinase	-	-	2.7.1.20	ko:K00856	ko00230,ko01100,map00230,map01100	-	R00185	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB
HKD1_k127_35064_3	1163617.SCD_n01106	1.187e-44	167.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,2VJTJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Belongs to the MtfA family	mtfA	-	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
HKD1_k127_3539843_0	187272.Mlg_0072	5.941e-158	508.0	COG1166@1|root,COG1166@2|Bacteria,1MU80@1224|Proteobacteria,1RP2J@1236|Gammaproteobacteria,1WWBM@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD1_k127_3539843_1	1116472.MGMO_112c00140	4.371e-125	406.0	COG0421@1|root,COG0421@2|Bacteria,1MVV5@1224|Proteobacteria,1RMUT@1236|Gammaproteobacteria,1XDNB@135618|Methylococcales	135618|Methylococcales	H	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HKD1_k127_3539843_2	1121033.AUCF01000013_gene1655	1.051e-65	230.0	COG1011@1|root,COG1011@2|Bacteria,1RHAB@1224|Proteobacteria,2U7PV@28211|Alphaproteobacteria,2JT7F@204441|Rhodospirillales	204441|Rhodospirillales	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_3556733_6	1353529.M899_0884	9.378e-30	120.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,42UTP@68525|delta/epsilon subdivisions,2MU92@213481|Bdellovibrionales,2WQM6@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD1_k127_3556733_0	1121033.AUCF01000009_gene1113	2.405e-151	487.0	COG1453@1|root,COG1453@2|Bacteria,1NIR6@1224|Proteobacteria,2U135@28211|Alphaproteobacteria,2JR5I@204441|Rhodospirillales	204441|Rhodospirillales	S	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_22
HKD1_k127_3556733_5	395963.Bind_0504	2.571e-38	152.0	COG0664@1|root,COG0664@2|Bacteria,1RII7@1224|Proteobacteria,2UA8E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_3556733_4	1121033.AUCF01000009_gene1114	3.372e-54	194.0	COG0664@1|root,COG0664@2|Bacteria,1RII7@1224|Proteobacteria,2UA8E@28211|Alphaproteobacteria,2JTAA@204441|Rhodospirillales	204441|Rhodospirillales	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_3556733_2	1430440.MGMSRv2_1307	5.599e-118	387.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2V6M0@28211|Alphaproteobacteria,2JQRT@204441|Rhodospirillales	204441|Rhodospirillales	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HKD1_k127_3556733_1	1121033.AUCF01000009_gene1116	2.535e-119	389.0	COG1941@1|root,COG1941@2|Bacteria,1NS0E@1224|Proteobacteria,2TVJC@28211|Alphaproteobacteria,2JR8M@204441|Rhodospirillales	204441|Rhodospirillales	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_3556733_3	1121033.AUCF01000009_gene1117	1.205e-96	321.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2TYKR@28211|Alphaproteobacteria,2JQJI@204441|Rhodospirillales	204441|Rhodospirillales	C	Nickel-dependent hydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	NiFeSe_Hases
HKD1_k127_3563788_3	472759.Nhal_3101	7.581e-10	60.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,1WWIM@135613|Chromatiales	135613|Chromatiales	G	TIGRFAM malto-oligosyltrehalose trehalohydrolase	-	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD1_k127_3563788_0	472759.Nhal_1492	5.382e-239	766.0	COG1262@1|root,COG1672@1|root,COG1262@2|Bacteria,COG1672@2|Bacteria,1RAMU@1224|Proteobacteria,1S87Q@1236|Gammaproteobacteria,1X2AR@135613|Chromatiales	135613|Chromatiales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_3563788_2	870187.Thini_3960	5.697e-14	86.0	COG0846@1|root,COG0846@2|Bacteria,1QU59@1224|Proteobacteria	1224|Proteobacteria	K	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2,TIR_2
HKD1_k127_3563788_1	765911.Thivi_1971	3.697e-49	183.0	2C5P4@1|root,3310H@2|Bacteria,1N6V1@1224|Proteobacteria,1SETV@1236|Gammaproteobacteria,1X14M@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3575533_2	522306.CAP2UW1_2323	1.038e-71	246.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria,2W0EW@28216|Betaproteobacteria	28216|Betaproteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
HKD1_k127_3575533_1	195250.CM001776_gene3143	2.243e-108	360.0	COG5464@1|root,COG5464@2|Bacteria,1G2UF@1117|Cyanobacteria,1H2QF@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF4351)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351
HKD1_k127_3575533_3	314278.NB231_14938	0.0001133	44.0	COG1196@1|root,COG4717@1|root,COG1196@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,1RZFW@1236|Gammaproteobacteria,1WX3B@135613|Chromatiales	135613|Chromatiales	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
HKD1_k127_3575533_0	251221.35213772	1.739e-311	977.0	COG3391@1|root,COG3391@2|Bacteria,1G3SH@1117|Cyanobacteria	2|Bacteria	M	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HKD1_k127_3586204_2	765912.Thimo_3426	1.768e-13	75.0	COG2770@1|root,COG5002@1|root,COG2770@2|Bacteria,COG5002@2|Bacteria,1QU7C@1224|Proteobacteria,1T1PS@1236|Gammaproteobacteria,1WVXX@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K07642	ko02020,map02020	M00450,M00645,M00646,M00648	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_3586204_0	596152.DesU5LDRAFT_1367	1.527e-108	359.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,42RYH@68525|delta/epsilon subdivisions,2WNT0@28221|Deltaproteobacteria,2MBQC@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_3586204_1	402777.KB235904_gene3975	1.136e-59	214.0	COG2189@1|root,COG2189@2|Bacteria,1G0NR@1117|Cyanobacteria,1H91K@1150|Oscillatoriales	1117|Cyanobacteria	L	DNA methylase	-	-	2.1.1.72	ko:K07316	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_3591396_1	187272.Mlg_1037	7.345e-159	516.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_3591396_2	439235.Dalk_3213	1.713e-149	493.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,42N2G@68525|delta/epsilon subdivisions,2WIXB@28221|Deltaproteobacteria,2MHUE@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM AMP-dependent synthetase and ligase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD1_k127_3591396_0	1123073.KB899241_gene1855	1.288e-169	540.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,1RMD9@1236|Gammaproteobacteria,1X3CD@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	GO:0003674,GO:0003824,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0018130,GO:0019438,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046116,GO:0046483,GO:0052693,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD1_k127_3591396_3	1123368.AUIS01000008_gene2246	1.372e-123	412.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	yfiQ	GO:0003674,GO:0003824,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006950,GO:0006979,GO:0008080,GO:0008150,GO:0008152,GO:0009266,GO:0009408,GO:0009628,GO:0009987,GO:0016043,GO:0016407,GO:0016410,GO:0016740,GO:0016746,GO:0016747,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019538,GO:0022607,GO:0032459,GO:0032462,GO:0034212,GO:0036211,GO:0043170,GO:0043254,GO:0043412,GO:0043543,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0052858,GO:0061733,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:1901564	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_3615198_9	472759.Nhal_3933	9.409e-73	261.0	COG3071@1|root,COG3071@2|Bacteria,1MU7A@1224|Proteobacteria,1RMRG@1236|Gammaproteobacteria,1X0CU@135613|Chromatiales	135613|Chromatiales	H	HemY domain protein	-	-	-	ko:K02498	-	-	-	-	ko00000	-	-	-	HemY_N
HKD1_k127_3615198_14	105559.Nwat_2586	7.571e-25	120.0	COG2959@1|root,COG2959@2|Bacteria,1MY3A@1224|Proteobacteria,1RNJY@1236|Gammaproteobacteria,1WZTH@135613|Chromatiales	135613|Chromatiales	H	HemX, putative uroporphyrinogen-III C-methyltransferase	-	-	2.1.1.107	ko:K02496	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	HemX
HKD1_k127_3615198_8	519989.ECTPHS_07501	2.028e-73	256.0	COG1587@1|root,COG1587@2|Bacteria,1MWZD@1224|Proteobacteria,1RM9K@1236|Gammaproteobacteria,1WWAM@135613|Chromatiales	135613|Chromatiales	H	Uroporphyrinogen III synthase	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD1_k127_3615198_2	561230.PC1_3980	5.118e-124	404.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,1RMQ8@1236|Gammaproteobacteria,1MQU0@122277|Pectobacterium	1236|Gammaproteobacteria	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006464,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018065,GO:0018130,GO:0018160,GO:0018193,GO:0018198,GO:0019438,GO:0019538,GO:0033013,GO:0033014,GO:0034641,GO:0036211,GO:0042168,GO:0042440,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	iEC55989_1330.EC55989_4275,iECH74115_1262.ECH74115_5243,iECIAI1_1343.ECIAI1_3991,iECO103_1326.ECO103_4362,iECO111_1330.ECO111_4628,iECO26_1355.ECO26_4784,iECSE_1348.ECSE_4086,iEKO11_1354.EKO11_4554,iPC815.YPO3849	Porphobil_deam,Porphobil_deamC
HKD1_k127_3615198_1	1209072.ALBT01000033_gene1595	4.481e-221	693.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,1RMA3@1236|Gammaproteobacteria,1FGE3@10|Cellvibrio	1236|Gammaproteobacteria	E	Argininosuccinate lyase C-terminal	argH	GO:0003674,GO:0003824,GO:0004056,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016829,GO:0016840,GO:0016842,GO:0019752,GO:0042450,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_3615198_3	472759.Nhal_2448	8.777e-107	357.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,1RNHU@1236|Gammaproteobacteria,1WW48@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_3615198_4	314278.NB231_02900	2.496e-97	325.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,1RSQ3@1236|Gammaproteobacteria,1WYU5@135613|Chromatiales	135613|Chromatiales	P	PFAM Rhodanese domain protein	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_3615198_7	396595.TK90_1847	1.467e-77	263.0	COG1949@1|root,COG1949@2|Bacteria,1R9WX@1224|Proteobacteria,1S217@1236|Gammaproteobacteria,1WWKA@135613|Chromatiales	135613|Chromatiales	L	3'-to-5' exoribonuclease specific for small oligoribonucleotides	orn	-	-	ko:K13288	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	RNase_T
HKD1_k127_3615198_5	1238190.AMQY01000018_gene1374	2.542e-89	306.0	COG1162@1|root,COG1162@2|Bacteria,1MUEF@1224|Proteobacteria,1RMMB@1236|Gammaproteobacteria,1XHIQ@135619|Oceanospirillales	135619|Oceanospirillales	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase
HKD1_k127_3615198_0	666685.R2APBS1_3835	1.677e-245	771.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1X329@135614|Xanthomonadales	135614|Xanthomonadales	NU	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD1_k127_3615198_13	187272.Mlg_0607	6.498e-29	120.0	2E45W@1|root,32SZG@2|Bacteria,1MZSG@1224|Proteobacteria,1S9BI@1236|Gammaproteobacteria,1WZ2A@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3615198_12	930169.B5T_01139	8.363e-35	136.0	COG4517@1|root,COG4517@2|Bacteria,1MZJX@1224|Proteobacteria,1S95D@1236|Gammaproteobacteria,1XKM3@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1820
HKD1_k127_3615198_10	118173.KB235914_gene940	1.165e-71	247.0	298Z8@1|root,2ZW30@2|Bacteria,1G5VW@1117|Cyanobacteria,1HBAX@1150|Oscillatoriales	1117|Cyanobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3615198_6	338966.Ppro_1649	9.73e-79	268.0	COG3064@1|root,COG3666@1|root,COG3064@2|Bacteria,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_3615198_15	933262.AXAM01000139_gene294	5.006e-24	105.0	COG5421@1|root,COG5421@2|Bacteria,1R7NE@1224|Proteobacteria,42M25@68525|delta/epsilon subdivisions,2WKHV@28221|Deltaproteobacteria,2MJVY@213118|Desulfobacterales	28221|Deltaproteobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_3615198_11	535289.Dtpsy_3185	7.262e-64	225.0	COG0863@1|root,COG0863@2|Bacteria,1R4QN@1224|Proteobacteria,2VP1E@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Mrr_N,N6_N4_Mtase
HKD1_k127_3615305_5	472759.Nhal_1739	1.664e-21	94.0	COG1662@1|root,COG3677@1|root,COG1662@2|Bacteria,COG3677@2|Bacteria,1NFF1@1224|Proteobacteria,1SEGH@1236|Gammaproteobacteria,1WZDG@135613|Chromatiales	135613|Chromatiales	L	PFAM IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1,Zn_Tnp_IS1
HKD1_k127_3615305_8	1038869.AXAN01000096_gene582	2.5e-05	48.0	COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
HKD1_k127_3615305_4	1049564.TevJSym_ao00640	3.172e-50	189.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1S92A@1236|Gammaproteobacteria,1J7AU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	DUF218 domain	Z012_07930	GO:0000270,GO:0005575,GO:0005623,GO:0005886,GO:0006022,GO:0006807,GO:0008150,GO:0008152,GO:0009273,GO:0009987,GO:0016020,GO:0016021,GO:0030203,GO:0031224,GO:0042546,GO:0043164,GO:0043170,GO:0044085,GO:0044425,GO:0044464,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901564	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_3615305_3	768671.ThimaDRAFT_1758	1.74e-172	548.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_3615305_0	243233.MCA2119	3.592e-268	832.0	COG1449@1|root,COG1449@2|Bacteria,1R3Z3@1224|Proteobacteria,1RNRC@1236|Gammaproteobacteria,1XG1U@135618|Methylococcales	135618|Methylococcales	G	Glycosyl hydrolase family 57	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_3615305_1	1487953.JMKF01000085_gene4327	2.473e-248	773.0	COG0297@1|root,COG0297@2|Bacteria,1G1YU@1117|Cyanobacteria,1H8IV@1150|Oscillatoriales	1117|Cyanobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA2	GO:0003674,GO:0003824,GO:0016740,GO:0016757	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_3615305_2	1283300.ATXB01000001_gene664	6.888e-185	587.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1XFWC@135618|Methylococcales	135618|Methylococcales	G	Alpha amylase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	hDGE_amylase
HKD1_k127_3615305_6	314278.NB231_11524	1.036e-07	53.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,1RMFF@1236|Gammaproteobacteria,1X0AC@135613|Chromatiales	135613|Chromatiales	C	dihydrolipoamide dehydrogenase	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_3615472_5	1499967.BAYZ01000097_gene4350	7.629e-114	380.0	COG4826@1|root,COG4826@2|Bacteria,2NQVB@2323|unclassified Bacteria	2|Bacteria	O	SERine  Proteinase INhibitors	-	-	-	ko:K13963	ko05146,map05146	-	-	-	ko00000,ko00001	-	-	-	Serpin
HKD1_k127_3615472_6	227377.CBU_1482	2.491e-104	344.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,1RNW8@1236|Gammaproteobacteria,1JDEC@118969|Legionellales	118969|Legionellales	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_3615472_3	1266925.JHVX01000004_gene1141	1.8e-152	495.0	COG1030@1|root,COG1030@2|Bacteria,1MUJN@1224|Proteobacteria,2VMUK@28216|Betaproteobacteria,372K1@32003|Nitrosomonadales	28216|Betaproteobacteria	O	NfeD-like C-terminal, partner-binding	nfeD	-	-	ko:K07403	-	-	-	-	ko00000	-	-	-	NfeD
HKD1_k127_3615472_16	221288.JH992901_gene2571	2.819e-30	130.0	COG1028@1|root,COG1028@2|Bacteria,1G0MD@1117|Cyanobacteria,1JIBJ@1189|Stigonemataceae	1117|Cyanobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_3615472_15	247633.GP2143_03983	8.553e-35	140.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1SDR7@1236|Gammaproteobacteria,1J72S@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_3615472_11	713587.THITH_13355	5.634e-50	186.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,1RPZ3@1236|Gammaproteobacteria,1WZFI@135613|Chromatiales	135613|Chromatiales	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD1_k127_3615472_1	1049564.TevJSym_at00510	4.357e-198	624.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1J5B1@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0008836,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0019752,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_3615472_17	754477.Q7C_2633	3.767e-19	97.0	COG3170@1|root,COG3170@2|Bacteria,1RDXQ@1224|Proteobacteria,1T42I@1236|Gammaproteobacteria,460XW@72273|Thiotrichales	72273|Thiotrichales	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_3615472_8	187272.Mlg_0515	1.097e-77	265.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,1RMHS@1236|Gammaproteobacteria,1WY1C@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD1_k127_3615472_2	1049564.TevJSym_af00850	5.059e-159	507.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,1RNZZ@1236|Gammaproteobacteria,1J58P@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	GO:0003674,GO:0003824,GO:0004641,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016882,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	iECSF_1327.ECSF_2340	AIRS,AIRS_C
HKD1_k127_3615472_10	323261.Noc_1186	2.169e-50	185.0	COG0558@1|root,COG0558@2|Bacteria,1MZ8B@1224|Proteobacteria,1SAHT@1236|Gammaproteobacteria,1WY27@135613|Chromatiales	135613|Chromatiales	I	PFAM CDP-alcohol phosphatidyltransferase	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_3615472_4	243233.MCA1229	8.069e-141	459.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,1XEH5@135618|Methylococcales	135618|Methylococcales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD1_k127_3615472_12	765912.Thimo_0573	6.15e-44	176.0	COG0810@1|root,COG0810@2|Bacteria,1RKRA@1224|Proteobacteria,1S6QG@1236|Gammaproteobacteria,1X2NB@135613|Chromatiales	135613|Chromatiales	M	Tol-Pal system TolA	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HKD1_k127_3615472_14	105559.Nwat_0132	5.061e-38	148.0	COG0848@1|root,COG0848@2|Bacteria,1MZ6M@1224|Proteobacteria,1S8RS@1236|Gammaproteobacteria,1WY2R@135613|Chromatiales	135613|Chromatiales	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	ExbD
HKD1_k127_3615472_9	323261.Noc_0142	2.713e-76	262.0	COG0811@1|root,COG0811@2|Bacteria,1NCWW@1224|Proteobacteria,1RMD4@1236|Gammaproteobacteria,1WWA0@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.2	-	-	MotA_ExbB
HKD1_k127_3615472_13	472759.Nhal_0179	2.261e-43	162.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,1S93F@1236|Gammaproteobacteria,1WYUJ@135613|Chromatiales	135613|Chromatiales	S	Tol-Pal system-associated acyl-CoA thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD1_k127_3615472_0	396588.Tgr7_2026	0.0	1119.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,1RNA6@1236|Gammaproteobacteria,1WW7V@135613|Chromatiales	135613|Chromatiales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_3615472_18	717774.Marme_3196	5.696e-14	83.0	COG3115@1|root,COG3115@2|Bacteria,1MVHR@1224|Proteobacteria,1RMDB@1236|Gammaproteobacteria,1XKA8@135619|Oceanospirillales	135619|Oceanospirillales	D	Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins	zipA	-	-	ko:K03528	-	-	-	-	ko00000,ko03036	-	-	-	ZipA_C
HKD1_k127_3615472_7	472759.Nhal_1449	1.373e-103	342.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,1RPAV@1236|Gammaproteobacteria,1WX4B@135613|Chromatiales	135613|Chromatiales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD1_k127_3615475_7	926550.CLDAP_07830	6.331e-52	194.0	COG4447@1|root,COG4447@2|Bacteria,2G66V@200795|Chloroflexi	200795|Chloroflexi	G	glycosyl hydrolase, BNR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_3615475_11	41431.PCC8801_4542	1.285e-36	143.0	COG4634@1|root,COG4634@2|Bacteria,1G720@1117|Cyanobacteria,3KJ3X@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3615475_10	489825.LYNGBM3L_05350	8.674e-40	150.0	COG2442@1|root,COG2442@2|Bacteria,1G71G@1117|Cyanobacteria,1HBYR@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_3615475_16	1173025.GEI7407_0339	6.172e-09	61.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HKD1_k127_3615475_14	1101190.ARWB01000001_gene1309	5.796e-11	72.0	COG2885@1|root,COG2885@2|Bacteria,1R6QU@1224|Proteobacteria,2TTMS@28211|Alphaproteobacteria,370KG@31993|Methylocystaceae	28211|Alphaproteobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_3615475_8	864702.OsccyDRAFT_3032	2.366e-45	170.0	COG0457@1|root,COG1293@1|root,COG4995@1|root,COG0457@2|Bacteria,COG1293@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H7GW@1150|Oscillatoriales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7,TPR_8
HKD1_k127_3615475_15	426114.THI_3788	1.443e-10	63.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,1KJ7D@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD1_k127_3615475_2	396588.Tgr7_1852	8.107e-147	472.0	COG0042@1|root,COG0042@2|Bacteria,1MUY1@1224|Proteobacteria,1RN28@1236|Gammaproteobacteria,1WW7E@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. Specifically modifies U20 and U20a in tRNAs	dusA	-	-	ko:K05539	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_3615475_0	349521.HCH_00005	4.894e-173	552.0	COG0661@1|root,COG0661@2|Bacteria,1N1UJ@1224|Proteobacteria,1RP1G@1236|Gammaproteobacteria,1XNJH@135619|Oceanospirillales	135619|Oceanospirillales	S	unusual protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC1,APH
HKD1_k127_3615475_6	1038922.PflQ2_0152	4.966e-62	222.0	COG0631@1|root,COG0631@2|Bacteria,1RFDT@1224|Proteobacteria,1SYCH@1236|Gammaproteobacteria,1YM41@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	T	serine threonine	pppA	-	3.1.3.16	ko:K11915	ko02025,ko03070,map02025,map03070	-	-	-	ko00000,ko00001,ko01000,ko02044	-	-	-	PP2C_2
HKD1_k127_3615475_1	519989.ECTPHS_08423	2.652e-159	513.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,1RN1D@1236|Gammaproteobacteria,1WWDA@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA	rlmD	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_3615475_4	472759.Nhal_2444	5.827e-116	381.0	COG3298@1|root,COG3298@2|Bacteria,1MVZJ@1224|Proteobacteria,1S4HU@1236|Gammaproteobacteria,1X0C4@135613|Chromatiales	135613|Chromatiales	L	3'-5' exonuclease	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
HKD1_k127_3615475_3	519989.ECTPHS_08413	3.696e-143	460.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1WX3I@135613|Chromatiales	135613|Chromatiales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3615475_5	305700.B447_08683	1.204e-93	318.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2VH5F@28216|Betaproteobacteria,2KVMM@206389|Rhodocyclales	206389|Rhodocyclales	F	Glucokinase	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HKD1_k127_3615475_17	1041930.Mtc_2288	1.639e-05	54.0	COG2202@1|root,arCOG02338@1|root,arCOG02338@2157|Archaea,arCOG06515@2157|Archaea	2157|Archaea	T	Contains one ATP-binding region, ATPase-like domain (IPR003594)	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,PAS_9,Response_reg
HKD1_k127_3615475_13	160492.XF_2081	1.032e-19	91.0	COG3077@1|root,COG3077@2|Bacteria,1NA1R@1224|Proteobacteria,1T16K@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	RelB antitoxin	-	-	-	ko:K07473	-	-	-	-	ko00000,ko02048	-	-	-	RelB
HKD1_k127_3615475_9	1395516.PMO01_28660	1.609e-43	159.0	COG3041@1|root,COG3041@2|Bacteria,1N0K0@1224|Proteobacteria,1SB57@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Bacterial toxin of type II toxin-antitoxin system, YafQ	-	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0006139,GO:0006401,GO:0006402,GO:0006412,GO:0006415,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009892,GO:0009987,GO:0010467,GO:0010468,GO:0010605,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016787,GO:0016788,GO:0019222,GO:0019439,GO:0019538,GO:0022411,GO:0032984,GO:0034641,GO:0034645,GO:0034655,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043624,GO:0043933,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044267,GO:0044270,GO:0044271,GO:0046483,GO:0046700,GO:0048519,GO:0050789,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901564,GO:1901566,GO:1901575,GO:1901576	-	ko:K19157	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	YafQ_toxin
HKD1_k127_3615475_12	322710.Avin_14300	9.154e-31	124.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RP5P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	hmm pf02371	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_3653927_2	876269.ARWA01000001_gene2312	5.227e-61	214.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,2TUG5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD1_k127_3653927_6	1123376.AUIU01000013_gene1910	1.376e-11	66.0	2EQ37@1|root,33HPJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3653927_4	1123367.C666_14375	1.078e-14	74.0	COG0600@1|root,COG0600@2|Bacteria,1MXRM@1224|Proteobacteria,2VJ1U@28216|Betaproteobacteria,2KV1I@206389|Rhodocyclales	206389|Rhodocyclales	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_3653927_7	203119.Cthe_2792	2.461e-11	70.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WHMC@541000|Ruminococcaceae	186801|Clostridia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2,LuxC
HKD1_k127_3653927_1	720554.Clocl_2724	2.358e-122	395.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WHMC@541000|Ruminococcaceae	186801|Clostridia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2,LuxC
HKD1_k127_3653927_3	1537915.JU57_01075	2.268e-27	119.0	COG1541@1|root,COG1541@2|Bacteria,1MV1W@1224|Proteobacteria,42NKD@68525|delta/epsilon subdivisions,2YN4Z@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_3653927_5	720554.Clocl_2724	6.092e-13	69.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,3WHMC@541000|Ruminococcaceae	186801|Clostridia	H	AMP-binding enzyme C-terminal domain	-	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2,LuxC
HKD1_k127_3653927_0	1183438.GKIL_3014	4.963e-213	669.0	COG0031@1|root,COG0031@2|Bacteria,1G0T4@1117|Cyanobacteria	1117|Cyanobacteria	E	cysteine synthase	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD1_k127_3668852_2	472759.Nhal_0530	4.774e-62	223.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,1WWQ3@135613|Chromatiales	135613|Chromatiales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD1_k127_3668852_3	523791.Kkor_1382	1.475e-44	168.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,1S682@1236|Gammaproteobacteria,1XJZU@135619|Oceanospirillales	135619|Oceanospirillales	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD1_k127_3668852_0	76114.ebA5820	4.085e-89	301.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2VHAQ@28216|Betaproteobacteria,2KUEU@206389|Rhodocyclales	206389|Rhodocyclales	V	Part of the ABC transporter complex LolCDE involved in the translocation of	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD1_k127_3668852_1	666681.M301_0658	8.409e-75	256.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2VH7C@28216|Betaproteobacteria,2KKB0@206350|Nitrosomonadales	206350|Nitrosomonadales	M	TIGRFAM lipoprotein releasing system, transmembrane protein, LolC E family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_3669361_5	107636.JQNK01000009_gene2246	4.333e-30	120.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TU4H@28211|Alphaproteobacteria,36X5M@31993|Methylocystaceae	28211|Alphaproteobacteria	G	HpcH/HpaI aldolase/citrate lyase family	mcl1	GO:0003674,GO:0003824,GO:0005488,GO:0016829,GO:0016830,GO:0016833,GO:0043167,GO:0043169,GO:0046872,GO:0047777,GO:0050083	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_3669361_6	395961.Cyan7425_2978	5.324e-16	83.0	COG3577@1|root,COG3577@2|Bacteria,1G657@1117|Cyanobacteria	1117|Cyanobacteria	S	Aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
HKD1_k127_3669361_4	1123502.AQXD01000003_gene1434	3.845e-57	205.0	COG3108@1|root,COG3108@2|Bacteria,1MWW2@1224|Proteobacteria,1RS5K@1236|Gammaproteobacteria,1X8YV@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacterial protein of unknown function (DUF882)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_2
HKD1_k127_3669361_2	330214.NIDE0034	3.235e-115	383.0	COG0842@1|root,COG0842@2|Bacteria,3J115@40117|Nitrospirae	40117|Nitrospirae	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_3669361_1	1123392.AQWL01000010_gene2282	2.812e-124	409.0	COG0842@1|root,COG0842@2|Bacteria,1QVX7@1224|Proteobacteria,2WH6V@28216|Betaproteobacteria	28216|Betaproteobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
HKD1_k127_3669361_0	1304885.AUEY01000051_gene1507	1.212e-252	797.0	COG1129@1|root,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,43BJ5@68525|delta/epsilon subdivisions,2X713@28221|Deltaproteobacteria,2MPNG@213118|Desulfobacterales	28221|Deltaproteobacteria	G	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990,ko:K13926	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3,ABC_tran
HKD1_k127_3669361_3	697282.Mettu_3938	1.296e-110	367.0	COG1566@1|root,COG1566@2|Bacteria,1QU7Z@1224|Proteobacteria,1T2MP@1236|Gammaproteobacteria,1XH0U@135618|Methylococcales	135618|Methylococcales	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_3670604_3	1049564.TevJSym_ao00690	6.301e-48	185.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1J5ZU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	rlpA	GO:0005575,GO:0005623,GO:0009279,GO:0016020,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0044462,GO:0044464,GO:0071944	-	ko:K03642	-	-	-	-	ko00000	-	-	-	DPBB_1,SPOR
HKD1_k127_3670604_2	1149133.ppKF707_0339	1.661e-98	333.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,1RMQ6@1236|Gammaproteobacteria,1YD2Q@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	M	Transglycosylase SLT domain	mltB	-	-	ko:K08305	-	-	-	-	ko00000,ko01000,ko01011	-	GH103	-	SLT_2
HKD1_k127_3670604_1	187272.Mlg_0173	8.143e-135	439.0	COG0772@1|root,COG0772@2|Bacteria,1MUK3@1224|Proteobacteria,1RMEJ@1236|Gammaproteobacteria,1WWAV@135613|Chromatiales	135613|Chromatiales	M	Peptidoglycan polymerase that is essential for cell wall elongation	mrdB	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD1_k127_3670604_0	765914.ThisiDRAFT_1432	2.519e-197	631.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,1RN9H@1236|Gammaproteobacteria,1WWAT@135613|Chromatiales	135613|Chromatiales	M	Catalyzes cross-linking of the peptidoglycan cell wall	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_3675910_0	713586.KB900536_gene484	2.035e-270	837.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,1RMFY@1236|Gammaproteobacteria,1WVVK@135613|Chromatiales	135613|Chromatiales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD1_k127_3675910_3	519989.ECTPHS_08276	6.055e-42	156.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,1S8XZ@1236|Gammaproteobacteria,1WYM5@135613|Chromatiales	135613|Chromatiales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himD	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_3675910_1	395493.BegalDRAFT_1798	1.515e-88	308.0	COG2956@1|root,COG2956@2|Bacteria,1MVDP@1224|Proteobacteria,1RP29@1236|Gammaproteobacteria,460FI@72273|Thiotrichales	72273|Thiotrichales	G	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane	lapB	-	-	ko:K19804	-	-	-	-	ko00000	-	-	-	TPR_16
HKD1_k127_3675910_2	105559.Nwat_0248	3.61e-78	266.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,1RMAE@1236|Gammaproteobacteria,1WWTZ@135613|Chromatiales	135613|Chromatiales	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD1_k127_3685941_0	1283300.ATXB01000001_gene1951	2.176e-255	799.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,1RN5R@1236|Gammaproteobacteria,1XDV1@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD1_k127_3685941_2	395493.BegalDRAFT_1266	3.986e-156	501.0	COG0722@1|root,COG0722@2|Bacteria,1MU5Q@1224|Proteobacteria,1RMAA@1236|Gammaproteobacteria,45ZQT@72273|Thiotrichales	72273|Thiotrichales	E	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)	-	-	-	-	-	-	-	-	-	-	-	-	DAHP_synth_1
HKD1_k127_3685941_5	1267535.KB906767_gene5521	2.396e-28	126.0	COG1678@1|root,COG1678@2|Bacteria,3Y8TX@57723|Acidobacteria	57723|Acidobacteria	K	Uncharacterized ACR, COG1678	-	-	-	-	-	-	-	-	-	-	-	-	DUF179
HKD1_k127_3685941_3	396588.Tgr7_2416	1.443e-83	282.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,1S21J@1236|Gammaproteobacteria,1WXJF@135613|Chromatiales	135613|Chromatiales	E	HAD-superfamily subfamily IB hydrolase, TIGR01490	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_3685941_4	519989.ECTPHS_02354	3.786e-70	242.0	COG0494@1|root,COG0494@2|Bacteria,1RDGJ@1224|Proteobacteria,1S3PQ@1236|Gammaproteobacteria,1WXC4@135613|Chromatiales	135613|Chromatiales	L	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HKD1_k127_3685941_1	713586.KB900536_gene1203	5.255e-242	770.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_3685941_6	522306.CAP2UW1_3347	2.2e-13	79.0	COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,2WFRP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Poly(hydroxyalcanoate) granule associated protein (phasin)	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD1_k127_3695055_4	391612.CY0110_32415	2.002e-12	70.0	2DTC9@1|root,33JP3@2|Bacteria,1GB2W@1117|Cyanobacteria,3KK6A@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3695055_1	472759.Nhal_1956	8.643e-116	382.0	COG2187@1|root,COG2187@2|Bacteria,1R98V@1224|Proteobacteria,1T025@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3695055_3	663610.JQKO01000011_gene3337	1.145e-50	194.0	2CI0K@1|root,33R79@2|Bacteria,1NTST@1224|Proteobacteria,2UP27@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD1_k127_3695055_0	472759.Nhal_2962	9.739e-132	427.0	COG0462@1|root,COG0462@2|Bacteria,1QHJ7@1224|Proteobacteria,1RZJH@1236|Gammaproteobacteria,1WZXT@135613|Chromatiales	135613|Chromatiales	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD1_k127_3695055_2	429009.Adeg_1135	2.513e-61	216.0	COG1926@1|root,COG1926@2|Bacteria,1V256@1239|Firmicutes,249BZ@186801|Clostridia,42GND@68295|Thermoanaerobacterales	186801|Clostridia	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_3724092_3	1121033.AUCF01000001_gene2390	2.904e-207	654.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2TRVS@28211|Alphaproteobacteria,2JQKB@204441|Rhodospirillales	204441|Rhodospirillales	G	Belongs to the glycosyl hydrolase 13 family	glgX	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_3724092_1	1123368.AUIS01000009_gene2439	1.831e-223	715.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,1RMJW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	4-alpha-glucanotransferase	malQ	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Glyco_hydro_77
HKD1_k127_3724092_14	582744.Msip34_0262	1.353e-19	91.0	COG5007@1|root,COG5007@2|Bacteria,1MZCZ@1224|Proteobacteria,2VU0K@28216|Betaproteobacteria,2KN4E@206350|Nitrosomonadales	206350|Nitrosomonadales	K	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD1_k127_3724092_4	396588.Tgr7_0742	2.015e-202	636.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,1RN91@1236|Gammaproteobacteria,1WXB6@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_3724092_11	519989.ECTPHS_01749	1.656e-92	310.0	COG0040@1|root,COG0040@2|Bacteria,1MUCY@1224|Proteobacteria,1RNAX@1236|Gammaproteobacteria,1WX3P@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD1_k127_3724092_5	1123400.KB904755_gene2587	1.026e-194	615.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,1RMZD@1236|Gammaproteobacteria,460BB@72273|Thiotrichales	72273|Thiotrichales	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_3724092_13	1173027.Mic7113_3430	3.839e-80	275.0	COG0518@1|root,COG0518@2|Bacteria,1G5B4@1117|Cyanobacteria,1HAM7@1150|Oscillatoriales	1117|Cyanobacteria	F	Glutamine amidotransferase class-I	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_3724092_2	1380391.JIAS01000003_gene1730	2.21e-216	683.0	COG3200@1|root,COG3200@2|Bacteria,1MUWF@1224|Proteobacteria,2TR0E@28211|Alphaproteobacteria,2JPFU@204441|Rhodospirillales	204441|Rhodospirillales	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	-	2.5.1.54	ko:K01626	ko00400,ko01100,ko01110,ko01130,ko01230,ko02024,map00400,map01100,map01110,map01130,map01230,map02024	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_2
HKD1_k127_3724092_10	279714.FuraDRAFT_1192	2.833e-97	323.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2VHY3@28216|Betaproteobacteria,2KQ1A@206351|Neisseriales	206351|Neisseriales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD1_k127_3724092_7	472759.Nhal_1736	7.701e-117	382.0	COG0390@1|root,COG0390@2|Bacteria,1MV2N@1224|Proteobacteria,1RSGA@1236|Gammaproteobacteria,1WW8S@135613|Chromatiales	135613|Chromatiales	S	PFAM conserved	-	-	-	ko:K02069	-	M00211	-	-	ko00000,ko00002,ko02000	9.B.25.1	-	-	UPF0014
HKD1_k127_3724092_12	472759.Nhal_1735	9.981e-81	273.0	COG1131@1|root,COG1131@2|Bacteria,1QW3E@1224|Proteobacteria,1T2RB@1236|Gammaproteobacteria,1X2NQ@135613|Chromatiales	135613|Chromatiales	V	ABC transporter	-	-	3.6.3.27	ko:K06021	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran
HKD1_k127_3724092_6	472759.Nhal_1112	4.189e-142	464.0	COG0535@1|root,COG0535@2|Bacteria,1MU07@1224|Proteobacteria,1RN94@1236|Gammaproteobacteria,1WXKU@135613|Chromatiales	135613|Chromatiales	S	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	DUF3641,Fer4_12,Radical_SAM
HKD1_k127_3724092_8	1123502.AQXD01000001_gene1321	4.945e-110	366.0	COG0598@1|root,COG0598@2|Bacteria,1MX09@1224|Proteobacteria,1RZ95@1236|Gammaproteobacteria,1X3T7@135614|Xanthomonadales	135614|Xanthomonadales	P	transport protein	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD1_k127_3724092_9	519989.ECTPHS_00230	7.195e-100	330.0	COG0209@1|root,COG0209@2|Bacteria,1P4EH@1224|Proteobacteria,1RP1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	COG0209 Ribonucleotide reductase, alpha subunit	nrdJb	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3724092_0	243233.MCA1677	4.853e-253	788.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,1RMD1@1236|Gammaproteobacteria,1XEEH@135618|Methylococcales	135618|Methylococcales	F	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_3724992_4	670292.JH26_04390	4.988e-08	54.0	COG3335@1|root,COG3335@2|Bacteria,1MW7X@1224|Proteobacteria,2TTH8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3335 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_32
HKD1_k127_3724992_1	1541065.JRFE01000028_gene3446	3.343e-37	146.0	COG3415@1|root,COG3415@2|Bacteria,1GA2F@1117|Cyanobacteria	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
HKD1_k127_3724992_0	1380391.JIAS01000011_gene5101	0.0	1339.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,2TSAE@28211|Alphaproteobacteria,2JPP9@204441|Rhodospirillales	204441|Rhodospirillales	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,MG1,PAN_1,Thiol-ester_cl
HKD1_k127_3724992_2	118168.MC7420_4925	4.688e-23	100.0	COG5464@1|root,COG5464@2|Bacteria,1GDRH@1117|Cyanobacteria,1HH0T@1150|Oscillatoriales	1117|Cyanobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3724992_3	765913.ThidrDRAFT_3600	4.851e-12	66.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_3725081_15	489825.LYNGBM3L_21200	1.947e-27	113.0	COG1132@1|root,COG1132@2|Bacteria,1G1JY@1117|Cyanobacteria,1H7BU@1150|Oscillatoriales	1117|Cyanobacteria	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_3725081_13	1123248.KB893322_gene635	1.286e-38	154.0	COG0110@1|root,COG0110@2|Bacteria,4NVA6@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD1_k127_3725081_12	1123248.KB893322_gene634	8.972e-40	157.0	COG0110@1|root,COG0110@2|Bacteria,4NVA6@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD1_k127_3725081_3	335543.Sfum_3551	1.945e-174	554.0	COG0438@1|root,COG0438@2|Bacteria,1RAGT@1224|Proteobacteria,42Y8X@68525|delta/epsilon subdivisions,2WU97@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3725081_8	1123248.KB893322_gene632	5.079e-79	278.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD1_k127_3725081_14	886293.Sinac_4405	1.459e-38	153.0	COG3394@1|root,COG3394@2|Bacteria	2|Bacteria	G	polysaccharide catabolic process	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HKD1_k127_3725081_7	251229.Chro_2996	8.285e-96	319.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,3VJ25@52604|Pleurocapsales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HKD1_k127_3725081_2	1123393.KB891333_gene2620	2.72e-200	638.0	COG0477@1|root,COG0477@2|Bacteria,1MXZ3@1224|Proteobacteria,2VH3E@28216|Betaproteobacteria,1KS9F@119069|Hydrogenophilales	119069|Hydrogenophilales	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_3725081_0	926550.CLDAP_37960	9.314e-292	902.0	COG0166@1|root,COG0166@2|Bacteria,2G5ZM@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_3725081_6	472759.Nhal_1060	1.234e-96	326.0	COG1341@1|root,COG1341@2|Bacteria,1NBYH@1224|Proteobacteria,1SN5N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	mRNA cleavage and polyadenylation factor CLP1 P-loop	-	-	-	ko:K06947	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	CLP1_P
HKD1_k127_3725081_10	1150469.RSPPHO_00403	9.946e-71	248.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,2JR8D@204441|Rhodospirillales	204441|Rhodospirillales	T	Universal stress protein UspA	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3725081_4	269796.Rru_A0890	2.824e-122	401.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,2TRRX@28211|Alphaproteobacteria,2JPPY@204441|Rhodospirillales	204441|Rhodospirillales	P	Integral membrane protein TerC family	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD1_k127_3725081_5	156889.Mmc1_2224	9.691e-110	364.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	BQ	Including yeast histone deacetylase and acetoin utilization protein	hdaH	-	-	ko:K04768	-	-	-	-	ko00000	-	-	-	Hist_deacetyl
HKD1_k127_3725081_1	1380358.JADJ01000024_gene2263	5.568e-231	743.0	COG2307@1|root,COG2308@1|root,COG2307@2|Bacteria,COG2308@2|Bacteria,1MX5P@1224|Proteobacteria,1RPDC@1236|Gammaproteobacteria,1XHK0@135619|Oceanospirillales	135619|Oceanospirillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E,CP_ATPgrasp_2
HKD1_k127_3725081_9	1122139.KB907880_gene2834	7.389e-76	261.0	COG1305@1|root,COG1305@2|Bacteria,1MVMI@1224|Proteobacteria,1RNV8@1236|Gammaproteobacteria,1XIQP@135619|Oceanospirillales	135619|Oceanospirillales	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_3826270_3	765911.Thivi_1183	6.578e-11	66.0	2BFY8@1|root,329TX@2|Bacteria,1R582@1224|Proteobacteria,1RY97@1236|Gammaproteobacteria,1WXMV@135613|Chromatiales	135613|Chromatiales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HKD1_k127_3826270_1	754477.Q7C_890	7.993e-35	136.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,1S8R8@1236|Gammaproteobacteria,460WE@72273|Thiotrichales	72273|Thiotrichales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD1_k127_3826270_2	314278.NB231_16003	2.251e-16	84.0	COG2965@1|root,COG2965@2|Bacteria,1RHIE@1224|Proteobacteria,1S6H5@1236|Gammaproteobacteria,1X20V@135613|Chromatiales	135613|Chromatiales	L	Binds single-stranded DNA at the primosome assembly site (PAS)	priB	-	-	ko:K02686	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SSB
HKD1_k127_3826270_0	713586.KB900536_gene2973	2.023e-50	182.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,1S5VU@1236|Gammaproteobacteria,1WYA2@135613|Chromatiales	135613|Chromatiales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD1_k127_383118_1	443143.GM18_0462	4.335e-141	469.0	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD1_k127_383118_2	443143.GM18_0461	5.1e-74	255.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,42ZR0@68525|delta/epsilon subdivisions,2WT3B@28221|Deltaproteobacteria,43UQ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_383118_4	1519464.HY22_02200	3.934e-22	100.0	COG5550@1|root,COG5550@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD1_k127_383118_3	864051.BurJ1DRAFT_4544	4.221e-65	227.0	COG1014@1|root,COG1014@2|Bacteria,1N12F@1224|Proteobacteria,2VQ8C@28216|Betaproteobacteria,1KKPN@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	porC	-	1.2.1.58,1.2.7.1	ko:K00172,ko:K18357	ko00010,ko00020,ko00360,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00360,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R02450,R08034	RC00004,RC00250,RC02742,RC02833,RC02860	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_383118_0	1123487.KB892840_gene75	3.753e-182	577.0	COG0674@1|root,COG0674@2|Bacteria,1MVM0@1224|Proteobacteria,2VJSA@28216|Betaproteobacteria,2KVEF@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate:ferredoxin oxidoreductase core domain II	padG	-	1.2.1.58	ko:K18355	ko00360,map00360	-	R02450	RC00004,RC02860	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_3842877_5	118166.JH976537_gene2469	2.153e-14	86.0	COG1511@1|root,COG1511@2|Bacteria,1G29D@1117|Cyanobacteria,1H90E@1150|Oscillatoriales	1117|Cyanobacteria	S	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,Tubulin_2,zinc_ribbon_2
HKD1_k127_3842877_1	317619.ANKN01000230_gene224	4.014e-45	177.0	COG1511@1|root,COG1511@2|Bacteria,1G29D@1117|Cyanobacteria	1117|Cyanobacteria	L	Tubulin like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4339,Tubulin_2,zinc_ribbon_2
HKD1_k127_3842877_2	1210884.HG799475_gene15308	1.913e-34	137.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,2IZAC@203682|Planctomycetes	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD1_k127_3842877_0	1123508.JH636448_gene7453	4.589e-62	217.0	COG3335@1|root,COG3335@2|Bacteria,2IZAC@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_3842877_3	1230476.C207_03676	7.592e-32	125.0	COG1396@1|root,COG1396@2|Bacteria,1MZQK@1224|Proteobacteria,2UCAK@28211|Alphaproteobacteria,3K0EH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD1_k127_3842877_4	1121861.KB899911_gene1293	5.133e-24	104.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,2JPXG@204441|Rhodospirillales	204441|Rhodospirillales	CP	Proton-conducting membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD1_k127_3866002_2	500153.JOEK01000001_gene3597	5.055e-60	217.0	COG2197@1|root,COG2197@2|Bacteria,2IAVX@201174|Actinobacteria	201174|Actinobacteria	KT	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3866002_0	102129.Lepto7375DRAFT_0196	2.742e-170	546.0	COG0657@1|root,COG0657@2|Bacteria,1G229@1117|Cyanobacteria,1HA06@1150|Oscillatoriales	1117|Cyanobacteria	I	Alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD1_k127_3866002_3	36809.MAB_4131	1.872e-29	123.0	2AYN4@1|root,31QSM@2|Bacteria,2HSX3@201174|Actinobacteria,23EDJ@1762|Mycobacteriaceae	201174|Actinobacteria	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD1_k127_3866002_1	1429046.RR21198_1702	1.043e-96	323.0	COG2021@1|root,COG3832@1|root,COG2021@2|Bacteria,COG3832@2|Bacteria,2GY9A@201174|Actinobacteria,4G0YQ@85025|Nocardiaceae	201174|Actinobacteria	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	-	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_3866002_4	671143.DAMO_2354	2.92e-25	109.0	COG1090@1|root,COG1090@2|Bacteria,2NPHC@2323|unclassified Bacteria	2|Bacteria	S	Domain of unknown function (DUF1731)	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
HKD1_k127_3878981_0	754476.Q7A_2971	3.116e-98	338.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,1MUKF@1224|Proteobacteria,1RMW6@1236|Gammaproteobacteria,45ZUT@72273|Thiotrichales	72273|Thiotrichales	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD1_k127_3878981_5	765420.OSCT_2516	7.561e-19	89.0	2EHRH@1|root,33BH9@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4926)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4926
HKD1_k127_3878981_4	1385935.N836_16850	1.504e-32	129.0	2E953@1|root,333DW@2|Bacteria,1G8VT@1117|Cyanobacteria,1HFXG@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3878981_3	99598.Cal7507_5422	2.148e-33	134.0	2FFXG@1|root,347UD@2|Bacteria,1GFES@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3878981_2	933262.AXAM01000171_gene926	6.163e-46	168.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,42UHK@68525|delta/epsilon subdivisions,2WQDH@28221|Deltaproteobacteria,2MPR9@213118|Desulfobacterales	28221|Deltaproteobacteria	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HKD1_k127_3878981_1	555779.Dthio_PD3202	5.52e-48	173.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,42VQB@68525|delta/epsilon subdivisions,2WRF4@28221|Deltaproteobacteria,2MD69@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	TIGRFAM Addiction module antidote protein, HigA	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HKD1_k127_3893345_3	1049564.TevJSym_al00340	2.798e-139	450.0	COG0309@1|root,COG0309@2|Bacteria,1MVCC@1224|Proteobacteria,1RQBE@1236|Gammaproteobacteria,1JA5R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	AIR synthase related protein, N-terminal domain	hypE	GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0018193,GO:0018198,GO:0018249,GO:0019538,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0046892,GO:0051604,GO:0071704,GO:1901564	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_3893345_10	1123519.PSJM300_15940	1.896e-41	158.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,1S6AJ@1236|Gammaproteobacteria,1YZP9@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006353,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD1_k127_3893345_7	395493.BegalDRAFT_1166	1.891e-65	227.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,1S3WD@1236|Gammaproteobacteria,460J0@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_3893345_1	472759.Nhal_2813	3.701e-160	511.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,1RQ49@1236|Gammaproteobacteria,1WW6K@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_3893345_5	1323663.AROI01000013_gene230	1.203e-89	300.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,1RMSY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Riboflavin synthase	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD1_k127_3893345_2	768671.ThimaDRAFT_3347	1.358e-143	464.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,1RN2M@1236|Gammaproteobacteria,1WVVQ@135613|Chromatiales	135613|Chromatiales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD1_k127_3893345_8	472759.Nhal_2810	1.62e-61	215.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,1S3P9@1236|Gammaproteobacteria,1WX91@135613|Chromatiales	135613|Chromatiales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_3893345_0	1283300.ATXB01000001_gene1535	4.802e-218	682.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,1RMHQ@1236|Gammaproteobacteria,1XECM@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD1_k127_3893345_6	1487953.JMKF01000059_gene4938	1.222e-70	245.0	COG4636@1|root,COG4636@2|Bacteria,1G5GG@1117|Cyanobacteria,1HAK2@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_3893345_9	472759.Nhal_2469	1.21e-57	206.0	COG0746@1|root,COG0746@2|Bacteria,1RH3M@1224|Proteobacteria,1S74N@1236|Gammaproteobacteria,1WY76@135613|Chromatiales	135613|Chromatiales	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_3893345_4	396588.Tgr7_1860	2.396e-111	365.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,1RP0Z@1236|Gammaproteobacteria,1WW0K@135613|Chromatiales	135613|Chromatiales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_3893345_12	1120944.JONS01000020_gene2254	1.062e-07	60.0	COG0702@1|root,COG0702@2|Bacteria,2I234@201174|Actinobacteria	201174|Actinobacteria	GM	NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD1_k127_3893345_11	472759.Nhal_3985	2.645e-11	63.0	COG1662@1|root,COG1662@2|Bacteria,1NFF1@1224|Proteobacteria,1SEGH@1236|Gammaproteobacteria,1WZDG@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1
HKD1_k127_3928757_2	1121033.AUCF01000032_gene2639	5.435e-140	450.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2JQYB@204441|Rhodospirillales	204441|Rhodospirillales	I	Belongs to the thiolase family	atoB	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_3928757_1	998674.ATTE01000001_gene3211	2.055e-179	567.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,1RMMJ@1236|Gammaproteobacteria,461U1@72273|Thiotrichales	72273|Thiotrichales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_3928757_0	269799.Gmet_3290	2.721e-286	885.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,42N6D@68525|delta/epsilon subdivisions,2X5IJ@28221|Deltaproteobacteria,43S1G@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Carboxyl transferase domain	mccB	-	6.4.1.4,6.4.1.5	ko:K01969,ko:K13778	ko00280,ko00281,ko01100,map00280,map00281,map01100	M00036	R03494,R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_3290	Carboxyl_trans
HKD1_k127_3946852_2	498211.CJA_0757	5.474e-47	182.0	COG0745@1|root,COG0784@1|root,COG5001@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1FFUY@10|Cellvibrio	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_3946852_0	105559.Nwat_1158	2.061e-173	568.0	COG1629@1|root,COG4771@2|Bacteria,1MUC1@1224|Proteobacteria,1RNHR@1236|Gammaproteobacteria,1WWBJ@135613|Chromatiales	135613|Chromatiales	M	TonB-dependent Receptor Plug	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD1_k127_3946852_1	1128421.JAGA01000002_gene1860	1.08e-92	319.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	KR,p450
HKD1_k127_3947668_1	671143.DAMO_0076	1.208e-20	93.0	COG2442@1|root,COG2442@2|Bacteria,2NRXV@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433,MerR_1
HKD1_k127_3947668_2	1089553.Tph_c02120	2.013e-20	95.0	COG4634@1|root,COG4634@2|Bacteria,1W2SH@1239|Firmicutes,255QC@186801|Clostridia,42IU3@68295|Thermoanaerobacterales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3947668_0	84531.JMTZ01000038_gene3624	2.259e-65	243.0	COG3562@1|root,COG3562@2|Bacteria,1QC30@1224|Proteobacteria,1T7R1@1236|Gammaproteobacteria,1X9KH@135614|Xanthomonadales	135614|Xanthomonadales	M	Capsule polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Capsule_synth
HKD1_k127_3947668_3	717606.PaecuDRAFT_4423	2.551e-19	102.0	COG4641@1|root,COG4641@2|Bacteria,1VHDC@1239|Firmicutes,4IPP4@91061|Bacilli,26R3E@186822|Paenibacillaceae	91061|Bacilli	S	Spore maturation protein	cgeB2	-	-	ko:K06320	-	-	-	-	ko00000	-	-	-	DUF3880,Glyco_trans_1_2
HKD1_k127_3965127_1	648757.Rvan_1081	1.65e-18	89.0	COG4959@1|root,COG4959@2|Bacteria,1RBHE@1224|Proteobacteria,2U9YP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	OU	Conjugal transfer protein TraF	traF	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S26
HKD1_k127_3965127_2	313606.M23134_05975	1.098e-15	89.0	COG4886@1|root,COG4886@2|Bacteria,4NPNU@976|Bacteroidetes,47KSK@768503|Cytophagia	976|Bacteroidetes	S	Leucine-rich repeat (LRR) protein	-	-	-	ko:K19613	ko04014,map04014	-	-	-	ko00000,ko00001	-	-	-	LRR_8
HKD1_k127_3965127_0	1173028.ANKO01000227_gene1232	7.521e-120	391.0	COG2513@1|root,COG2513@2|Bacteria,1G300@1117|Cyanobacteria,1H9AY@1150|Oscillatoriales	1117|Cyanobacteria	G	COG2513 PEP phosphonomutase and related enzymes	-	-	4.1.3.30	ko:K03417	ko00640,map00640	-	R00409	RC00286,RC00287	ko00000,ko00001,ko01000	-	-	-	PEP_mutase
HKD1_k127_402394_3	1123368.AUIS01000009_gene2494	8.228e-58	206.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,1RPAN@1236|Gammaproteobacteria,2NC9N@225057|Acidithiobacillales	225057|Acidithiobacillales	G	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_402394_1	349521.HCH_06817	1.727e-60	221.0	COG0524@1|root,COG0524@2|Bacteria,1QTMT@1224|Proteobacteria,1S1JQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD1_k127_402394_4	765913.ThidrDRAFT_2819	9.15e-50	182.0	COG0758@1|root,COG0758@2|Bacteria,1MZGB@1224|Proteobacteria,1S95S@1236|Gammaproteobacteria,1WYBS@135613|Chromatiales	135613|Chromatiales	LU	Putative molybdenum carrier	-	-	-	-	-	-	-	-	-	-	-	-	MoCo_carrier
HKD1_k127_402394_2	272123.Anacy_2880	2.93e-59	211.0	2C12C@1|root,32R7Y@2|Bacteria,1GJ74@1117|Cyanobacteria,1HQRZ@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_402394_5	688245.CtCNB1_1618	2.14e-36	145.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2VSP6@28216|Betaproteobacteria,4ADHE@80864|Comamonadaceae	28216|Betaproteobacteria	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD1_k127_402394_6	396588.Tgr7_2227	1.988e-32	139.0	COG1729@1|root,COG1729@2|Bacteria,1MUSV@1224|Proteobacteria,1RQWA@1236|Gammaproteobacteria,1WW2G@135613|Chromatiales	135613|Chromatiales	D	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division	cpoB	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri,YfiO
HKD1_k127_402394_0	497965.Cyan7822_5141	5.905e-75	263.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1G1QI@1117|Cyanobacteria,3KHNA@43988|Cyanothece	1117|Cyanobacteria	K	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,TPR_10,TPR_12,TPR_7,TPR_8
HKD1_k127_4025420_0	1163617.SCD_n02327	3.483e-72	248.0	COG0778@1|root,COG0778@2|Bacteria,1RA6E@1224|Proteobacteria,2VSIM@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Pfam Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4025420_1	1198232.CYCME_2225	4.358e-52	188.0	COG0684@1|root,COG0684@2|Bacteria,1RH18@1224|Proteobacteria,1RS9U@1236|Gammaproteobacteria,462ED@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions	-	-	-	ko:K02553	-	-	-	-	ko00000,ko03019	-	-	-	RraA-like
HKD1_k127_4025420_2	472759.Nhal_3276	7.905e-33	129.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,1RMB9@1236|Gammaproteobacteria,1WWMF@135613|Chromatiales	135613|Chromatiales	O	PFAM Magnesium chelatase, ChlI subunit	-	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_4047726_1	1244869.H261_17408	1.369e-142	458.0	COG1740@1|root,COG1740@2|Bacteria,1MWAC@1224|Proteobacteria,2TSVK@28211|Alphaproteobacteria,2JQIC@204441|Rhodospirillales	204441|Rhodospirillales	C	NiFe/NiFeSe hydrogenase small subunit C-terminal	-	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6
HKD1_k127_4047726_6	395493.BegalDRAFT_3214	3.375e-26	114.0	COG1773@1|root,COG1773@2|Bacteria,1N813@1224|Proteobacteria,1SCZ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	[NiFe]-hydrogenase assembly, chaperone, HybE	hoxT	-	-	-	-	-	-	-	-	-	-	-	NiFe-hyd_HybE
HKD1_k127_4047726_3	2340.JV46_26660	5.534e-41	156.0	COG0680@1|root,COG0680@2|Bacteria,1N3AS@1224|Proteobacteria,1SZPN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD1_k127_4047726_7	2340.JV46_26670	3.525e-24	108.0	2DNYF@1|root,32ZSU@2|Bacteria,1N8ZB@1224|Proteobacteria,1S5ZH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM HupH hydrogenase expression protein	-	-	-	ko:K03618	-	-	-	-	ko00000	-	-	-	HupH_C
HKD1_k127_4047726_5	391612.CY0110_27415	8.178e-29	119.0	COG1708@1|root,COG1708@2|Bacteria,1GAR8@1117|Cyanobacteria	1117|Cyanobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4047726_11	913865.DOT_4258	2.848e-05	47.0	COG2405@1|root,COG2405@2|Bacteria,1VBDK@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF3368)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3368
HKD1_k127_4047726_8	768671.ThimaDRAFT_3664	2.309e-21	96.0	COG2886@1|root,COG2886@2|Bacteria,1NN0R@1224|Proteobacteria,1SHXH@1236|Gammaproteobacteria,1WZPH@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0175	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
HKD1_k127_4047726_0	1144275.COCOR_02741	1.425e-168	535.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,42ZA3@68525|delta/epsilon subdivisions,2WUE3@28221|Deltaproteobacteria,2Z36C@29|Myxococcales	28221|Deltaproteobacteria	F	Metal binding domain of Ada	-	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18
HKD1_k127_4047726_9	690850.Desaf_2940	1.495e-19	93.0	COG0122@1|root,COG0122@2|Bacteria	2|Bacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247,ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HKD1_k127_4047726_10	1249627.D779_3185	8.773e-19	94.0	COG4634@1|root,COG4634@2|Bacteria,1RH7A@1224|Proteobacteria,1SBJT@1236|Gammaproteobacteria,1X1A3@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4047726_4	1496688.ER33_15395	4.484e-31	123.0	COG2442@1|root,COG2442@2|Bacteria,1GKGU@1117|Cyanobacteria,22TRK@167375|Cyanobium	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_4047726_2	572477.Alvin_0309	6.195e-58	213.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVV9@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_9,Response_reg
HKD1_k127_4057471_4	1206731.BAGB01000173_gene43	9.54e-08	62.0	COG0702@1|root,COG0702@2|Bacteria,2GK71@201174|Actinobacteria,4G092@85025|Nocardiaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
HKD1_k127_4057471_3	402777.KB235904_gene3829	1.755e-17	93.0	COG0513@1|root,COG0513@2|Bacteria,1G201@1117|Cyanobacteria,1H9BU@1150|Oscillatoriales	1117|Cyanobacteria	JKL	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C
HKD1_k127_4057471_1	1173025.GEI7407_2070	5.84e-179	578.0	COG0513@1|root,COG0513@2|Bacteria,1G201@1117|Cyanobacteria,1H9BU@1150|Oscillatoriales	1117|Cyanobacteria	JKL	Helicase conserved C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C
HKD1_k127_4057471_2	1120983.KB894575_gene596	3.505e-59	211.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,1JN9I@119043|Rhodobiaceae	28211|Alphaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_4057471_0	414684.RC1_0515	8.678e-238	741.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2TR5K@28211|Alphaproteobacteria,2JPD9@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_407342_3	686340.Metal_1859	1.973e-104	342.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,1RQU2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_407342_2	686340.Metal_1860	2.43e-106	350.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1XE0E@135618|Methylococcales	1236|Gammaproteobacteria	E	ABC transporter	-	-	-	ko:K01996,ko:K11963	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
HKD1_k127_407342_1	472759.Nhal_3797	9.079e-157	505.0	COG2807@1|root,COG2807@2|Bacteria,1QW3Y@1224|Proteobacteria,1T2RW@1236|Gammaproteobacteria,1X2P1@135613|Chromatiales	135613|Chromatiales	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	MFS_1
HKD1_k127_407342_4	1301098.PKB_5662	6.946e-95	314.0	COG0461@1|root,COG0461@2|Bacteria,1MW6F@1224|Proteobacteria,1RQYG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	GO:0000287,GO:0003674,GO:0003824,GO:0004588,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019856,GO:0034641,GO:0034654,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046483,GO:0046872,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_2819,iECIAI39_1322.ECIAI39_4161,iEcSMS35_1347.EcSMS35_3977,iUTI89_1310.UTI89_C4186	Pribosyltran
HKD1_k127_407342_0	237368.SCABRO_02885	2.155e-169	537.0	COG1064@1|root,COG1064@2|Bacteria,2IY4H@203682|Planctomycetes	203682|Planctomycetes	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_4074307_2	269799.Gmet_0420	3.058e-47	176.0	COG1309@1|root,COG1309@2|Bacteria,1N6R3@1224|Proteobacteria,42VN1@68525|delta/epsilon subdivisions,2WRVD@28221|Deltaproteobacteria,43UW7@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N,WHG
HKD1_k127_4074307_1	243231.GSU2697	1.8e-182	579.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,43T2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD1_k127_4074307_0	316067.Geob_1226	0.0	1313.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4077733_1	870187.Thini_0524	8.2e-109	362.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,1RQPH@1236|Gammaproteobacteria,460IP@72273|Thiotrichales	72273|Thiotrichales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_4077733_0	690850.Desaf_0999	8.973e-169	541.0	COG1752@1|root,COG1752@2|Bacteria,1NT1Q@1224|Proteobacteria,42T9D@68525|delta/epsilon subdivisions,2WUA3@28221|Deltaproteobacteria,2MA48@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	PFAM Patatin	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD1_k127_4087796_2	472759.Nhal_3458	6.992e-59	213.0	COG0500@1|root,COG2226@2|Bacteria,1QTWC@1224|Proteobacteria,1RS4G@1236|Gammaproteobacteria,1WXQH@135613|Chromatiales	135613|Chromatiales	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_4087796_0	472759.Nhal_2490	0.0	1007.0	COG0366@1|root,COG0366@2|Bacteria,1MWBZ@1224|Proteobacteria,1RYKS@1236|Gammaproteobacteria,1WX35@135613|Chromatiales	135613|Chromatiales	G	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB	glgE	-	2.4.99.16	ko:K16147	ko00500,ko01100,map00500,map01100	-	R09994	-	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,DUF3416
HKD1_k127_4087796_1	1283300.ATXB01000001_gene2251	3.315e-81	278.0	COG0436@1|root,COG0436@2|Bacteria,1MWS8@1224|Proteobacteria,1RPGJ@1236|Gammaproteobacteria,1XDYG@135618|Methylococcales	135618|Methylococcales	E	Aminotransferase, class I	-	-	2.6.1.17	ko:K14267	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04475	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_4090293_2	2340.JV46_28470	3.236e-14	77.0	COG3197@1|root,COG3197@2|Bacteria,1PUQV@1224|Proteobacteria,1RW07@1236|Gammaproteobacteria,1J76Y@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome oxidase maturation protein cbb3-type	-	-	-	-	-	-	-	-	-	-	-	-	FixS
HKD1_k127_4090293_0	572477.Alvin_0285	1.09e-95	324.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1MWCC@1224|Proteobacteria,1RNGC@1236|Gammaproteobacteria,1WWQN@135613|Chromatiales	135613|Chromatiales	H	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_4090293_1	1026882.MAMP_02916	5.688e-45	172.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,1S99V@1236|Gammaproteobacteria,4610E@72273|Thiotrichales	72273|Thiotrichales	K	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD1_k127_4090585_4	240016.ABIZ01000001_gene398	8.775e-05	46.0	COG5421@1|root,COG5421@2|Bacteria,46U8B@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_4090585_0	1249627.D779_3943	1.734e-143	472.0	COG3316@1|root,COG3316@2|Bacteria,1QE29@1224|Proteobacteria,1T5ZZ@1236|Gammaproteobacteria,1X2WN@135613|Chromatiales	135613|Chromatiales	L	Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
HKD1_k127_4090585_3	272123.Anacy_2095	1.369e-05	49.0	COG1848@1|root,COG1848@2|Bacteria,1G8T6@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4090585_1	272123.Anacy_2095	1.722e-13	70.0	COG1848@1|root,COG1848@2|Bacteria,1G8T6@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4090585_2	1162668.LFE_0018	1.077e-05	47.0	2DPTZ@1|root,333CW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4095958_1	1123367.C666_09180	1.278e-269	838.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2VHAT@28216|Betaproteobacteria,2KW0Z@206389|Rhodocyclales	206389|Rhodocyclales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_4095958_4	1121033.AUCF01000010_gene4576	2.152e-171	550.0	COG1593@1|root,COG1593@2|Bacteria,1MUQE@1224|Proteobacteria,2TSSE@28211|Alphaproteobacteria,2JPVC@204441|Rhodospirillales	204441|Rhodospirillales	G	Malonyl-CoA decarboxylase N-terminal domain	-	-	4.1.1.9	ko:K01578	ko00410,ko00640,ko01100,ko04146,ko04152,map00410,map00640,map01100,map04146,map04152	-	R00233	RC00040	ko00000,ko00001,ko01000	-	-	-	MCD,MCD_N
HKD1_k127_4095958_3	1049564.TevJSym_ar00580	3.875e-209	669.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,1RNVR@1236|Gammaproteobacteria,1J52N@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	kefB	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_C,TrkA_N
HKD1_k127_4095958_2	323261.Noc_2021	3.466e-222	722.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WVZ7@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS,PAS_3,PAS_4,Response_reg
HKD1_k127_4095958_5	287.DR97_2717	1.734e-70	256.0	COG1639@1|root,COG2606@1|root,COG1639@2|Bacteria,COG2606@2|Bacteria,1MXVB@1224|Proteobacteria,1RMNV@1236|Gammaproteobacteria,1YF1U@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	HDOD,tRNA_edit
HKD1_k127_4095958_6	748247.AZKH_0496	1.465e-10	71.0	COG3087@1|root,COG3087@2|Bacteria,1RI6A@1224|Proteobacteria,2VR10@28216|Betaproteobacteria,2KWVJ@206389|Rhodocyclales	206389|Rhodocyclales	D	cell division protein	ftsN	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD1_k127_4095958_0	1049564.TevJSym_ak00590	6.347e-270	841.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,1RPRC@1236|Gammaproteobacteria,1J5IS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Arginyl-tRNA synthetase	argS	GO:0003674,GO:0003824,GO:0004812,GO:0004814,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006420,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_4107421_2	571166.KI421509_gene3764	2.342e-15	82.0	2CBRD@1|root,32RTX@2|Bacteria,1R5XB@1224|Proteobacteria,2U1IV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4107421_0	1123393.KB891317_gene2424	1.616e-99	342.0	COG0845@1|root,COG0845@2|Bacteria,1PQHB@1224|Proteobacteria,2VHZR@28216|Betaproteobacteria,1KSQC@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4107421_1	748247.AZKH_4475	1.897e-22	97.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,2KURD@206389|Rhodocyclales	206389|Rhodocyclales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07239	-	-	-	-	ko00000	2.A.6.1	-	-	ACR_tran
HKD1_k127_4112980_4	1049564.TevJSym_aa00890	1.459e-58	206.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1J6RI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Insulinase (Peptidase family M16)	-	-	2.7.7.6	ko:K00960,ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4112980_2	572477.Alvin_2886	1.194e-64	226.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,1RN21@1236|Gammaproteobacteria,1WY3H@135613|Chromatiales	135613|Chromatiales	L	Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD1_k127_4112980_3	349124.Hhal_2309	4.809e-64	224.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,1S41J@1236|Gammaproteobacteria,1WY42@135613|Chromatiales	135613|Chromatiales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_4112980_5	1123354.AUDR01000016_gene1343	1.16e-39	148.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,1KRT0@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_4112980_6	672.VV93_v1c15790	5.698e-19	88.0	COG0687@1|root,COG0687@2|Bacteria,1MUYW@1224|Proteobacteria,1RM7W@1236|Gammaproteobacteria,1XUH1@135623|Vibrionales	135623|Vibrionales	P	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K11069	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	SBP_bac_6,SBP_bac_8
HKD1_k127_4112980_0	1283300.ATXB01000001_gene2451	2.08e-149	478.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,1RNN8@1236|Gammaproteobacteria,1XE5H@135618|Methylococcales	135618|Methylococcales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD1_k127_4112980_1	323261.Noc_0849	6.635e-81	279.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales	135613|Chromatiales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD1_k127_4127563_1	1249627.D779_0779	7.228e-52	192.0	COG3916@1|root,COG3916@2|Bacteria,1RCQC@1224|Proteobacteria,1S3K2@1236|Gammaproteobacteria,1WYXI@135613|Chromatiales	135613|Chromatiales	QT	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_5
HKD1_k127_4127563_0	323848.Nmul_A0374	3.468e-190	606.0	COG0476@1|root,COG0778@1|root,COG0476@2|Bacteria,COG0778@2|Bacteria,1PDX3@1224|Proteobacteria,2VNSD@28216|Betaproteobacteria,37268@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Nitroreductase family	moeY	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4139827_1	596152.DesU5LDRAFT_3901	5.233e-51	185.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,42NCD@68525|delta/epsilon subdivisions,2WJ03@28221|Deltaproteobacteria,2M7UG@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD1_k127_4139827_0	768671.ThimaDRAFT_4273	8.583e-70	247.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2887,DUF4351
HKD1_k127_4139827_8	1123367.C666_13095	0.0001018	47.0	COG2002@1|root,COG2002@2|Bacteria,1PUEQ@1224|Proteobacteria,2VXRM@28216|Betaproteobacteria	28216|Betaproteobacteria	K	SpoVT / AbrB like domain	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PrlF_antitoxin
HKD1_k127_4139827_6	314278.NB231_06531	2.242e-07	56.0	COG5611@1|root,COG5611@2|Bacteria,1PD30@1224|Proteobacteria,1SHWJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4139827_7	314278.NB231_06531	1.976e-05	48.0	COG5611@1|root,COG5611@2|Bacteria,1PD30@1224|Proteobacteria,1SHWJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4139827_9	1174528.JH992898_gene4276	0.0006682	47.0	COG1672@1|root,COG1672@2|Bacteria,1GHSE@1117|Cyanobacteria,1JK1F@1189|Stigonemataceae	1117|Cyanobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HKD1_k127_4139827_4	1333856.L686_08445	3.584e-15	75.0	COG1943@1|root,COG1943@2|Bacteria,1MZZT@1224|Proteobacteria,1S9JG@1236|Gammaproteobacteria,1Z300@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_4139827_3	251221.35212592	3.317e-18	86.0	COG4118@1|root,COG4118@2|Bacteria,1GA3X@1117|Cyanobacteria	1117|Cyanobacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4139827_5	102125.Xen7305DRAFT_00043360	1.006e-13	72.0	COG3744@1|root,COG3744@2|Bacteria,1G89C@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4139827_2	1170562.Cal6303_3743	2.165e-27	114.0	COG3744@1|root,COG3744@2|Bacteria,1G89C@1117|Cyanobacteria	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4196951_2	631362.Thi970DRAFT_04572	1.708e-41	159.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RP5P@1236|Gammaproteobacteria,1WXEY@135613|Chromatiales	135613|Chromatiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_4196951_1	768671.ThimaDRAFT_0924	5.853e-142	458.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,1RP2Y@1236|Gammaproteobacteria,1WW3U@135613|Chromatiales	135613|Chromatiales	T	PFAM PhoH family protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD1_k127_4196951_0	713586.KB900536_gene1139	1.399e-221	694.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_4201520_5	1380347.JNII01000005_gene3355	0.0006591	45.0	COG1247@1|root,COG1247@2|Bacteria,2IMVR@201174|Actinobacteria,4EWXB@85013|Frankiales	201174|Actinobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_4201520_2	1210884.HG799463_gene9859	6.507e-14	74.0	arCOG13559@1|root,33239@2|Bacteria,2J0W1@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD1_k127_4201520_1	1123508.JH636449_gene7262	8.793e-16	80.0	arCOG13559@1|root,33239@2|Bacteria,2J0W1@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD1_k127_4201520_4	504728.K649_02580	5.46e-06	48.0	COG3293@1|root,COG3293@2|Bacteria,1WKI8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	L	COG3293 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096
HKD1_k127_4201520_3	1123508.JH636444_gene5594	1.316e-08	55.0	COG3293@1|root,COG3293@2|Bacteria,2IX9I@203682|Planctomycetes	203682|Planctomycetes	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD1_k127_4201520_0	891974.E05_43890	1.069e-45	171.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_4212414_10	384765.SIAM614_04550	4.766e-20	93.0	COG0274@1|root,COG0274@2|Bacteria,1N8AG@1224|Proteobacteria,2TS26@28211|Alphaproteobacteria	28211|Alphaproteobacteria	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD1_k127_4212414_5	420324.KI912031_gene2787	2.754e-46	170.0	COG0295@1|root,COG0295@2|Bacteria,1MY2R@1224|Proteobacteria,2U9FW@28211|Alphaproteobacteria,1JV0P@119045|Methylobacteriaceae	28211|Alphaproteobacteria	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1,dCMP_cyt_deam_2
HKD1_k127_4212414_6	435832.HMPREF0604_01421	1.759e-45	173.0	COG0790@1|root,COG0790@2|Bacteria,1MWPA@1224|Proteobacteria,2VM3A@28216|Betaproteobacteria,2KQPW@206351|Neisseriales	206351|Neisseriales	S	Sel1-like repeats.	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD1_k127_4212414_13	1299327.I546_3299	0.0001616	46.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,235BW@1762|Mycobacteriaceae	201174|Actinobacteria	E	Serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_4212414_11	487521.OCU_20430	2.553e-09	63.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,235BW@1762|Mycobacteriaceae	201174|Actinobacteria	E	Serine acetyltransferase	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_4212414_3	243233.MCA1022	1.476e-67	231.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,1RN6J@1236|Gammaproteobacteria,1XDN6@135618|Methylococcales	135618|Methylococcales	H	Belongs to the cysteine synthase cystathionine beta- synthase family	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4212414_12	526226.Gbro_4035	0.000134	47.0	COG0607@1|root,COG0607@2|Bacteria,2IN3Q@201174|Actinobacteria,4GE5W@85026|Gordoniaceae	201174|Actinobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_4212414_7	335543.Sfum_1291	4.646e-42	158.0	COG1959@1|root,COG1959@2|Bacteria,1PC6N@1224|Proteobacteria,43EVM@68525|delta/epsilon subdivisions,2X9SC@28221|Deltaproteobacteria,2MSFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_4212414_8	243365.CV_3182	2.34e-28	121.0	COG5553@1|root,COG5553@2|Bacteria,1NXEP@1224|Proteobacteria	1224|Proteobacteria	C	Cysteine dioxygenase type I	-	-	1.13.11.20	ko:K00456	ko00270,ko00430,ko01100,map00270,map00430,map01100	-	R00893	RC00404	ko00000,ko00001,ko01000	-	-	-	CDO_I
HKD1_k127_4212414_0	118173.KB235914_gene1759	1.594e-149	488.0	COG4529@1|root,COG4529@2|Bacteria,1GQFF@1117|Cyanobacteria,1HE4T@1150|Oscillatoriales	1117|Cyanobacteria	S	FAD-NAD(P)-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_9
HKD1_k127_4212414_9	159087.Daro_4127	1.499e-25	117.0	COG2200@1|root,COG2200@2|Bacteria,1N62A@1224|Proteobacteria,2VUYI@28216|Betaproteobacteria,2M02R@206389|Rhodocyclales	206389|Rhodocyclales	T	EAL domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL
HKD1_k127_4212414_2	1000565.METUNv1_00924	4.427e-68	237.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,2VHQY@28216|Betaproteobacteria,2KUAP@206389|Rhodocyclales	206389|Rhodocyclales	K	Transcriptional regulator	-	-	-	ko:K13635	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4212414_1	102129.Lepto7375DRAFT_8306	4.49e-116	386.0	COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria,1HHEJ@1150|Oscillatoriales	1117|Cyanobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD1_k127_4212414_4	1040989.AWZU01000015_gene2677	1.721e-60	214.0	COG2855@1|root,COG2855@2|Bacteria,1MVPE@1224|Proteobacteria,2TUG5@28211|Alphaproteobacteria,3JX6C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Conserved hypothetical protein 698	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD1_k127_4214530_5	1283300.ATXB01000001_gene369	6.256e-134	436.0	COG3853@1|root,COG3853@2|Bacteria,1MZ3B@1224|Proteobacteria,1RZUJ@1236|Gammaproteobacteria,1XE81@135618|Methylococcales	135618|Methylococcales	P	Belongs to the TelA family	-	-	-	-	-	-	-	-	-	-	-	-	TelA
HKD1_k127_4214530_9	768671.ThimaDRAFT_0027	1.299e-76	265.0	COG4915@1|root,COG4915@2|Bacteria,1P3PC@1224|Proteobacteria,1S1ZJ@1236|Gammaproteobacteria,1WX47@135613|Chromatiales	1236|Gammaproteobacteria	S	PFAM 5-bromo-4-chloroindolyl phosphate hydrolysis protein	-	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
HKD1_k127_4214530_15	1454004.AW11_03510	9.982e-30	124.0	COG3937@1|root,COG3937@2|Bacteria,1N1EW@1224|Proteobacteria,2WFRP@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Poly(hydroxyalcanoate) granule associated protein (phasin)	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD1_k127_4214530_4	1123508.JH636440_gene2322	3.144e-195	623.0	COG0402@1|root,COG0402@2|Bacteria,2J1ZA@203682|Planctomycetes	203682|Planctomycetes	F	MGS-like domain	-	-	-	-	-	-	-	-	-	-	-	-	MGS
HKD1_k127_4214530_2	391615.ABSJ01000029_gene1955	5.358e-221	689.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,1RMEC@1236|Gammaproteobacteria,1J4BT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	GO:0000050,GO:0000053,GO:0003674,GO:0003824,GO:0004055,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006575,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0019627,GO:0019752,GO:0034641,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:0072350,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_4214530_20	545696.HOLDEFILI_02195	1.035e-05	48.0	COG1605@1|root,COG1605@2|Bacteria	2|Bacteria	E	Chorismate mutase	aroK	-	1.1.1.25,2.7.1.71,5.4.99.5	ko:K00014,ko:K00891,ko:K04092,ko:K04516	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022,M00024,M00025	R01715,R02412,R02413	RC00002,RC00078,RC00206,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI
HKD1_k127_4214530_8	522306.CAP2UW1_2822	1.101e-76	263.0	COG1215@1|root,COG1215@2|Bacteria,1RA75@1224|Proteobacteria,2VQQD@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_4214530_10	472759.Nhal_0868	2.543e-66	231.0	COG3222@1|root,COG3222@2|Bacteria,1RB1V@1224|Proteobacteria,1S971@1236|Gammaproteobacteria,1WYN8@135613|Chromatiales	135613|Chromatiales	S	Uncharacterized protein conserved in bacteria (DUF2064)	-	-	-	ko:K09931	-	-	-	-	ko00000	-	-	-	DUF2064
HKD1_k127_4214530_11	765911.Thivi_4548	2.208e-64	226.0	COG2078@1|root,COG2078@2|Bacteria,1RJP4@1224|Proteobacteria,1S6FG@1236|Gammaproteobacteria,1WY34@135613|Chromatiales	135613|Chromatiales	S	pfam ammecr1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HKD1_k127_4214530_6	243233.MCA0072	2.006e-105	347.0	COG1355@1|root,COG1355@2|Bacteria,1MXK5@1224|Proteobacteria,1RQPK@1236|Gammaproteobacteria,1XEER@135618|Methylococcales	135618|Methylococcales	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD1_k127_4214530_3	472759.Nhal_3602	3.123e-201	631.0	COG1180@1|root,COG1180@2|Bacteria,1R8XY@1224|Proteobacteria,1T0C7@1236|Gammaproteobacteria,1X2MB@135613|Chromatiales	135613|Chromatiales	O	Radical SAM superfamily	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_4214530_7	243231.GSU0792	1.364e-81	278.0	COG3332@1|root,COG3332@2|Bacteria,1RDBS@1224|Proteobacteria,42QS8@68525|delta/epsilon subdivisions,2WMV7@28221|Deltaproteobacteria,43SGZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Transport and Golgi organisation 2	-	-	-	-	-	-	-	-	-	-	-	-	TANGO2
HKD1_k127_4214530_12	1111479.AXAR01000005_gene557	1.487e-50	191.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4HBT0@91061|Bacilli,278VM@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD1_k127_4214530_17	768671.ThimaDRAFT_4095	1.22e-26	115.0	2AE70@1|root,3140Y@2|Bacteria,1RK0Q@1224|Proteobacteria,1S6JU@1236|Gammaproteobacteria,1WYRY@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4214530_14	317619.ANKN01000039_gene61	1.106e-37	146.0	COG4636@1|root,COG4636@2|Bacteria,1GGUY@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4214530_13	56110.Oscil6304_3176	1.254e-40	153.0	COG4634@1|root,COG4634@2|Bacteria,1G7AE@1117|Cyanobacteria,1HCGR@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4214530_16	864702.OsccyDRAFT_5060	2.696e-29	120.0	COG2442@1|root,COG2442@2|Bacteria,1G72R@1117|Cyanobacteria,1HCMC@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_4214530_19	1249627.D779_3038	5.887e-11	65.0	COG5464@1|root,COG5464@2|Bacteria,1PXZD@1224|Proteobacteria,1RQBS@1236|Gammaproteobacteria,1WXJI@135613|Chromatiales	135613|Chromatiales	S	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351
HKD1_k127_4214530_0	649747.HMPREF0083_06147	0.0	1208.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1TQAD@1239|Firmicutes,4H9QB@91061|Bacilli,2726S@186822|Paenibacillaceae	91061|Bacilli	I	Methylmalonyl-CoA mutase	mutB	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HKD1_k127_4214530_1	383372.Rcas_3871	6.659e-244	773.0	COG1884@1|root,COG1884@2|Bacteria,2G5TP@200795|Chloroflexi,376FY@32061|Chloroflexia	32061|Chloroflexia	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD1_k127_4214530_18	338969.Rfer_2801	3.667e-26	108.0	COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,4ADFN@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_4232423_6	765912.Thimo_0175	3.326e-71	242.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_4232423_11	1158150.KB906241_gene1067	4.019e-42	156.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,1S8YR@1236|Gammaproteobacteria,1WYJ2@135613|Chromatiales	135613|Chromatiales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_4232423_14	857087.Metme_0399	5.213e-14	74.0	COG3100@1|root,COG3100@2|Bacteria,1N83J@1224|Proteobacteria,1SCCD@1236|Gammaproteobacteria,1XFQQ@135618|Methylococcales	135618|Methylococcales	S	PFAM YcgL domain	-	-	-	ko:K09902	-	-	-	-	ko00000	-	-	-	YcgL
HKD1_k127_4232423_7	1163617.SCD_n02043	2.491e-70	243.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2VR34@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Reversible hydration of carbon dioxide	cynT	GO:0003674,GO:0003824,GO:0004089,GO:0005488,GO:0008150,GO:0008270,GO:0015976,GO:0016829,GO:0016835,GO:0016836,GO:0043167,GO:0043169,GO:0046872,GO:0046914	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_4232423_8	187272.Mlg_2879	4.219e-57	206.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,1RMRZ@1236|Gammaproteobacteria,1WXDT@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD1_k127_4232423_5	314285.KT71_04835	1.401e-95	319.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,1RNJK@1236|Gammaproteobacteria,1J5A9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	ATPases involved in chromosome partitioning	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_4232423_4	472759.Nhal_3954	5.804e-97	324.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,1WWNZ@135613|Chromatiales	135613|Chromatiales	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_4232423_13	519989.ECTPHS_08793	4.381e-16	83.0	COG3312@1|root,COG3312@2|Bacteria	2|Bacteria	C	ATP synthase I chain	atpI	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044464,GO:0044769,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	iSSON_1240.SSON_3880	ATP-synt_I
HKD1_k127_4232423_2	697282.Mettu_2149	9.359e-112	366.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,1RPHK@1236|Gammaproteobacteria,1XE4P@135618|Methylococcales	135618|Methylococcales	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_4232423_12	697282.Mettu_2150	2.105e-37	142.0	COG0636@1|root,32S3K@2|Bacteria,1N1NA@1224|Proteobacteria,1S9MD@1236|Gammaproteobacteria,1XFHC@135618|Methylococcales	135618|Methylococcales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_4232423_9	713586.KB900536_gene2127	8.989e-50	181.0	COG0711@1|root,COG0711@2|Bacteria,1RHZ0@1224|Proteobacteria,1S402@1236|Gammaproteobacteria,1WYT5@135613|Chromatiales	135613|Chromatiales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_4232423_10	396588.Tgr7_3308	1.758e-46	173.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,1S8X2@1236|Gammaproteobacteria,1WY1N@135613|Chromatiales	135613|Chromatiales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD1_k127_4232423_0	713586.KB900536_gene2125	2.568e-266	827.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,1RP4V@1236|Gammaproteobacteria,1WVYR@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD1_k127_4232423_3	1042375.AFPL01000043_gene1408	4.129e-108	357.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,1RNWJ@1236|Gammaproteobacteria,4655C@72275|Alteromonadaceae	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0036442,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045261,GO:0045262,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0046961,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iSSON_1240.SSON_3886,iYL1228.KPN_04138	ATP-synt
HKD1_k127_4232423_1	765914.ThisiDRAFT_2272	8.075e-240	747.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,1RN6U@1236|Gammaproteobacteria,1WW2C@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_4236820_2	1121887.AUDK01000003_gene2599	0.0004424	52.0	COG3307@1|root,COG3307@2|Bacteria,4NHG7@976|Bacteroidetes,1II7Q@117743|Flavobacteriia,2P0BC@237|Flavobacterium	976|Bacteroidetes	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD1_k127_4236820_1	1101195.Meth11DRAFT_1923	9.471e-69	246.0	COG1216@1|root,COG1216@2|Bacteria	2|Bacteria	V	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glycos_transf_2
HKD1_k127_4236820_0	296591.Bpro_3393	3.01e-236	747.0	COG0204@1|root,COG0236@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0236@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,4AB3C@80864|Comamonadaceae	28216|Betaproteobacteria	IQ	PFAM AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,Acyltransferase,PP-binding
HKD1_k127_4239499_8	163908.KB235896_gene3240	0.0009163	43.0	COG0732@1|root,COG0732@2|Bacteria,1G1K5@1117|Cyanobacteria	1117|Cyanobacteria	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_4239499_0	713586.KB900537_gene3235	6.083e-59	219.0	COG1192@1|root,COG1192@2|Bacteria,1MVJU@1224|Proteobacteria,1T16I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	AAA domain	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,MerR
HKD1_k127_4239499_1	1396858.Q666_14870	5.607e-56	206.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,1RN65@1236|Gammaproteobacteria,4649M@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_4239499_3	545276.KB898727_gene465	7.244e-19	91.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,1WXFP@135613|Chromatiales	135613|Chromatiales	L	Belongs to the UPF0758 family	-	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD1_k127_4239499_6	1127673.GLIP_2833	4.463e-10	62.0	COG2003@1|root,COG2003@2|Bacteria,1MXZ5@1224|Proteobacteria,1RP86@1236|Gammaproteobacteria,466E7@72275|Alteromonadaceae	1236|Gammaproteobacteria	E	Belongs to the UPF0758 family	radC	GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD1_k127_4239499_4	768671.ThimaDRAFT_4273	1.958e-12	72.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2887,DUF4351
HKD1_k127_4239499_5	56110.Oscil6304_1753	6.347e-12	68.0	COG5464@1|root,COG5464@2|Bacteria,1G0S6@1117|Cyanobacteria,1HAHI@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF2887)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2887,DUF4351
HKD1_k127_4239499_7	67315.JOBD01000004_gene5667	0.0009065	44.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,2GJB4@201174|Actinobacteria	201174|Actinobacteria	CE	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
HKD1_k127_4239499_2	32057.KB217478_gene2481	1.192e-30	122.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HNK2@1161|Nostocales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
HKD1_k127_4245009_0	472759.Nhal_1129	3.414e-170	551.0	COG5421@1|root,COG5421@2|Bacteria,1R25F@1224|Proteobacteria,1RZQP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4277
HKD1_k127_4256305_3	570967.JMLV01000012_gene3195	1.069e-124	406.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,2JPI2@204441|Rhodospirillales	204441|Rhodospirillales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_4256305_9	272134.KB731324_gene3563	0.0001222	46.0	COG1672@1|root,COG5635@1|root,COG1672@2|Bacteria,COG5635@2|Bacteria,1G192@1117|Cyanobacteria,1H737@1150|Oscillatoriales	1117|Cyanobacteria	T	Ntpase (Nacht family)	-	-	-	-	-	-	-	-	-	-	-	-	NACHT
HKD1_k127_4256305_7	472759.Nhal_0601	1.056e-13	76.0	COG4636@1|root,COG4636@2|Bacteria,1RJC2@1224|Proteobacteria,1S7B0@1236|Gammaproteobacteria,1WYIQ@135613|Chromatiales	135613|Chromatiales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_4256305_1	765912.Thimo_1686	3.1e-271	852.0	COG0480@1|root,COG0480@2|Bacteria,1PMU3@1224|Proteobacteria,1S00P@1236|Gammaproteobacteria,1WXBY@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_4256305_4	331869.BAL199_10180	1.209e-110	363.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,4BPKP@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	I	enoyl-CoA hydratase isomerase family	MA20_15895	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_4256305_6	395493.BegalDRAFT_2596	2.03e-40	151.0	COG3492@1|root,COG3492@2|Bacteria,1MZ3I@1224|Proteobacteria,1S8SI@1236|Gammaproteobacteria,462VS@72273|Thiotrichales	72273|Thiotrichales	S	Protein of unknown function (DUF1244)	-	-	-	ko:K09948	-	-	-	-	ko00000	-	-	-	DUF1244
HKD1_k127_4256305_2	187272.Mlg_1280	3.553e-154	492.0	COG2896@1|root,COG2896@2|Bacteria,1MW3W@1224|Proteobacteria,1RR68@1236|Gammaproteobacteria,1WW2B@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HKD1_k127_4256305_8	1026882.MAMP_01207	2.439e-06	51.0	COG0596@1|root,COG0596@2|Bacteria,1QUBR@1224|Proteobacteria,1RSF9@1236|Gammaproteobacteria,463VW@72273|Thiotrichales	72273|Thiotrichales	S	The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters	bioH	-	3.1.1.85	ko:K02170	ko00780,ko01100,map00780,map01100	M00572	R09725	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_4256305_5	323261.Noc_2546	4.097e-64	225.0	COG4636@1|root,COG4636@2|Bacteria,1R58B@1224|Proteobacteria,1RSKS@1236|Gammaproteobacteria,1WXM1@135613|Chromatiales	135613|Chromatiales	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_4256305_0	266117.Rxyl_2529	1.027e-276	869.0	COG2902@1|root,COG2902@2|Bacteria,2GK0C@201174|Actinobacteria,4CPJ1@84995|Rubrobacteria	84995|Rubrobacteria	E	Bacterial NAD-glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HKD1_k127_4290049_4	87626.PTD2_04958	6.584e-09	59.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4290049_3	697282.Mettu_3881	6.474e-20	93.0	2DIE3@1|root,302Y1@2|Bacteria,1QPR0@1224|Proteobacteria,1SJHJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD1_k127_4290049_0	1384056.N787_05765	5.451e-83	282.0	COG2908@1|root,COG2908@2|Bacteria,1N3U7@1224|Proteobacteria,1RP1X@1236|Gammaproteobacteria,1X5K2@135614|Xanthomonadales	135614|Xanthomonadales	S	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxH	-	3.6.1.54	ko:K03269	ko00540,ko01100,map00540,map01100	M00060	R04549	RC00002	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Metallophos,Metallophos_2
HKD1_k127_4290049_1	1249627.D779_3236	1.621e-71	244.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,1S222@1236|Gammaproteobacteria,1WYD7@135613|Chromatiales	135613|Chromatiales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_4290049_2	1123504.JQKD01000029_gene4217	4.234e-67	233.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2VQ6F@28216|Betaproteobacteria,4ADGN@80864|Comamonadaceae	28216|Betaproteobacteria	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiA	-	5.2.1.8	ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_4290049_5	349124.Hhal_0108	4.232e-07	51.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1S14K@1236|Gammaproteobacteria,1X0FN@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_4315243_1	713586.KB900536_gene719	4.47e-103	340.0	COG0005@1|root,COG0005@2|Bacteria,1MUWW@1224|Proteobacteria,1RS0S@1236|Gammaproteobacteria,1WWNN@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1- phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine	-	-	2.4.2.28,2.4.2.44	ko:K00772,ko:K19696	ko00270,ko01100,map00270,map01100	M00034	R01402,R09668	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_4315243_0	396588.Tgr7_0895	3.625e-196	624.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,1WWKZ@135613|Chromatiales	135613|Chromatiales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_4315243_2	399741.Spro_0429	2.834e-29	119.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,1RM89@1236|Gammaproteobacteria,4010Y@613|Serratia	1236|Gammaproteobacteria	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	GO:0000018,GO:0000166,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019219,GO:0019222,GO:0030554,GO:0031323,GO:0032300,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051171,GO:0051716,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1990391	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_4315243_3	324602.Caur_1017	8.583e-17	81.0	COG0243@1|root,COG0243@2|Bacteria,2G5X7@200795|Chloroflexi,3752D@32061|Chloroflexia	32061|Chloroflexia	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_4326429_11	489825.LYNGBM3L_05150	1.455e-41	161.0	COG1652@1|root,COG1652@2|Bacteria,1G8DU@1117|Cyanobacteria,1HCCZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_4326429_1	1173028.ANKO01000114_gene6164	6.674e-115	381.0	COG3500@1|root,COG3500@2|Bacteria,1G4DS@1117|Cyanobacteria,1H8S8@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage late control gene D protein (GPD)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
HKD1_k127_4326429_3	489825.LYNGBM3L_03970	1.799e-68	239.0	COG3501@1|root,COG3501@2|Bacteria,1G6H3@1117|Cyanobacteria,1HBBA@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage-related baseplate assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4326429_2	63737.Npun_R1097	9.281e-69	236.0	COG4104@1|root,COG4104@2|Bacteria,1G6FA@1117|Cyanobacteria	1117|Cyanobacteria	S	PAAR motif	-	-	-	-	-	-	-	-	-	-	-	-	PAAR_motif
HKD1_k127_4326429_12	489825.LYNGBM3L_05190	3.109e-40	153.0	COG3628@1|root,COG3628@2|Bacteria,1G77W@1117|Cyanobacteria,1HBKJ@1150|Oscillatoriales	1117|Cyanobacteria	S	Gene 25-like lysozyme	-	-	-	ko:K06903	-	-	-	-	ko00000	-	-	-	GPW_gp25
HKD1_k127_4326429_0	489825.LYNGBM3L_03940	1.286e-202	666.0	COG3299@1|root,COG3299@2|Bacteria,1G0Z2@1117|Cyanobacteria,1H91X@1150|Oscillatoriales	1117|Cyanobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
HKD1_k127_4326429_5	489825.LYNGBM3L_03930	5.888e-66	239.0	COG3299@1|root,COG3299@2|Bacteria,1G6J6@1117|Cyanobacteria,1HBV9@1150|Oscillatoriales	1117|Cyanobacteria	S	Baseplate J-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Baseplate_J
HKD1_k127_4326429_14	489825.LYNGBM3L_03910	2.728e-19	97.0	COG4385@1|root,COG4385@2|Bacteria,1G2G6@1117|Cyanobacteria,1H77I@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Phage tail protein (Tail_P2_I)	-	-	-	-	-	-	-	-	-	-	-	-	Tail_P2_I
HKD1_k127_4326429_16	489825.LYNGBM3L_03900	2.493e-11	75.0	COG4385@1|root,COG5295@1|root,COG4385@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	ko:K09942,ko:K21449	-	-	-	-	ko00000,ko02000	1.B.40.2	-	-	Peptidase_S74,YadA_head,YadA_stalk
HKD1_k127_4326429_7	1370121.AUWS01000040_gene4332	2.558e-55	205.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,233BZ@1762|Mycobacteriaceae	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_4326429_20	525897.Dbac_0163	6.775e-05	53.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,42PIF@68525|delta/epsilon subdivisions,2WMSZ@28221|Deltaproteobacteria,2MC84@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,Gly-zipper_YMGG,OmpA
HKD1_k127_4326429_4	1121456.ATVA01000011_gene1714	1.8e-68	248.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,42MHD@68525|delta/epsilon subdivisions,2WJKC@28221|Deltaproteobacteria,2M7RV@213115|Desulfovibrionales	68525|delta/epsilon subdivisions	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD1_k127_4326429_6	521460.Athe_1045	1.157e-57	218.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_4326429_19	10224.XP_006811375.1	3.149e-06	60.0	COG5021@1|root,KOG4276@2759|Eukaryota	2759|Eukaryota	O	protein ubiquitination	-	GO:0000151,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0019005,GO:0019222,GO:0019538,GO:0019899,GO:0019941,GO:0030162,GO:0030163,GO:0031461,GO:0031625,GO:0032991,GO:0043161,GO:0043170,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044389,GO:0044424,GO:0044464,GO:0050789,GO:0051171,GO:0051246,GO:0051603,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1990234	-	ko:K05288	ko00563,ko01100,map00563,map01100	-	R05923,R08107	RC00017	ko00000,ko00001	-	-	-	BACK,BTB,F5_F8_type_C,HECT,MIB_HERC2,Methyltransf_FA,SPRY
HKD1_k127_4326429_18	344747.PM8797T_06120	1.947e-07	64.0	COG1716@1|root,COG1716@2|Bacteria,2J10W@203682|Planctomycetes	203682|Planctomycetes	T	COG1716 FOG FHA domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Yop-YscD_cpl
HKD1_k127_4326429_10	273677.BW34_01654	6.302e-44	172.0	COG0631@1|root,COG0631@2|Bacteria,2GJ3M@201174|Actinobacteria,4FKJ0@85023|Microbacteriaceae	201174|Actinobacteria	T	Protein phosphatase 2C	pstP	GO:0000287,GO:0001932,GO:0001933,GO:0003674,GO:0003824,GO:0004647,GO:0004721,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006464,GO:0006469,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009892,GO:0009987,GO:0010563,GO:0010605,GO:0016020,GO:0016021,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019220,GO:0019222,GO:0019538,GO:0030145,GO:0030312,GO:0031224,GO:0031226,GO:0031323,GO:0031324,GO:0031399,GO:0031400,GO:0032268,GO:0032269,GO:0033673,GO:0036211,GO:0042325,GO:0042326,GO:0042578,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043392,GO:0043412,GO:0043549,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0045859,GO:0045936,GO:0046872,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051098,GO:0051100,GO:0051101,GO:0051171,GO:0051172,GO:0051174,GO:0051246,GO:0051248,GO:0051338,GO:0051348,GO:0060255,GO:0065007,GO:0065009,GO:0071704,GO:0071944,GO:0080090,GO:0140096,GO:1901564	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD1_k127_4326429_22	2002.JOEQ01000029_gene8218	0.0009656	49.0	COG1716@1|root,COG1716@2|Bacteria,2GNU2@201174|Actinobacteria,4EFW3@85012|Streptosporangiales	201174|Actinobacteria	T	Protein of unknown function (DUF2662)	fhaA	GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0030312,GO:0044424,GO:0044444,GO:0044464,GO:0071944,GO:0097159,GO:1901363	-	-	-	-	-	-	-	-	-	-	DUF3662,FHA,Yop-YscD_cpl
HKD1_k127_4326429_17	1121423.JONT01000013_gene364	3.456e-08	64.0	COG1716@1|root,COG1716@2|Bacteria,1VF0E@1239|Firmicutes,24P12@186801|Clostridia,262T0@186807|Peptococcaceae	186801|Clostridia	T	PFAM Forkhead-associated	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD1_k127_4326429_21	533240.CRC_02336	0.0002922	49.0	COG3755@1|root,COG3755@2|Bacteria,1G85T@1117|Cyanobacteria,1HU1R@1161|Nostocales	1117|Cyanobacteria	S	Pfam:DUF1311	-	-	-	-	-	-	-	-	-	-	-	-	LprI
HKD1_k127_4326429_8	1499967.BAYZ01000154_gene1521	3.52e-53	191.0	COG3409@1|root,COG3772@1|root,COG3409@2|Bacteria,COG3772@2|Bacteria	2|Bacteria	S	cytolysis by virus of host cell	-	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	Amidase_2,CW_binding_1,PG_binding_1,Phage_lysozyme
HKD1_k127_4326429_13	518766.Rmar_1773	1.554e-29	119.0	COG2442@1|root,COG2442@2|Bacteria,4P9SY@976|Bacteroidetes,1FKBB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Protein of unknown function (DUF433)	-	-	-	-	-	-	-	-	-	-	-	-	DUF433
HKD1_k127_4326429_15	32049.SYNPCC7002_A2861	4.111e-14	75.0	COG4634@1|root,COG4634@2|Bacteria,1G8GI@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4326429_9	118161.KB235920_gene5993	4.956e-48	181.0	COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria,3VNFJ@52604|Pleurocapsales	1117|Cyanobacteria	O	ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_4338633_5	1150469.RSPPHO_01430	1.803e-08	58.0	COG0415@1|root,COG0415@2|Bacteria,1MV9Y@1224|Proteobacteria,2TSDP@28211|Alphaproteobacteria,2JQ32@204441|Rhodospirillales	204441|Rhodospirillales	L	Belongs to the DNA photolyase family	phrB	-	4.1.99.3	ko:K01669	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_photolyase,FAD_binding_7
HKD1_k127_4338633_2	1469607.KK073768_gene2621	4.878e-62	219.0	298Z8@1|root,2ZW30@2|Bacteria,1G5VW@1117|Cyanobacteria,1HRK7@1161|Nostocales	1117|Cyanobacteria	S	K COG5665 CCR4-NOT transcriptional regulation complex, NOT5 subunit	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4338633_6	340177.Cag_1504	0.0005064	46.0	COG0457@1|root,COG1672@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,1FEF0@1090|Chlorobi	1090|Chlorobi	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7
HKD1_k127_4338633_4	557598.LHK_01008	4.793e-11	75.0	COG5339@1|root,COG5339@2|Bacteria,1R5PZ@1224|Proteobacteria,2VIVC@28216|Betaproteobacteria,2KQB0@206351|Neisseriales	206351|Neisseriales	S	Bacterial protein of unknown function (DUF945)	-	-	-	-	-	-	-	-	-	-	-	-	DUF945
HKD1_k127_4338633_1	324602.Caur_2175	1.52e-109	375.0	2BEFV@1|root,32CHX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4338633_0	1207063.P24_03186	7.844e-254	796.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2JPVD@204441|Rhodospirillales	204441|Rhodospirillales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
HKD1_k127_4338633_3	83406.HDN1F_12940	2.168e-16	81.0	COG3937@1|root,COG3937@2|Bacteria,1N7X8@1224|Proteobacteria,1T08C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Polyhydroxyalkanoate granule-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD1_k127_4344196_0	525897.Dbac_1160	7.68e-121	395.0	COG2006@1|root,COG2006@2|Bacteria,1QMGX@1224|Proteobacteria,42PRJ@68525|delta/epsilon subdivisions,2WMFN@28221|Deltaproteobacteria,2M8ZX@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_4344196_1	879212.DespoDRAFT_02026	2.064e-72	254.0	COG0348@1|root,COG0437@1|root,COG0348@2|Bacteria,COG0437@2|Bacteria,1N9WY@1224|Proteobacteria,42MXM@68525|delta/epsilon subdivisions,2X743@28221|Deltaproteobacteria,2MJAZ@213118|Desulfobacterales	28221|Deltaproteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_5,Fer4_7
HKD1_k127_4344196_2	1049564.TevJSym_ba00250	2.304e-66	239.0	COG4255@1|root,COG4255@2|Bacteria,1RA9X@1224|Proteobacteria,1S23W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	rpfE	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4344196_3	1049564.TevJSym_bm00250	1.617e-55	204.0	29T7N@1|root,30EEF@2|Bacteria,1RHQ8@1224|Proteobacteria,1S6XD@1236|Gammaproteobacteria,1JAQE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1461)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1461
HKD1_k127_4344196_4	1183438.GKIL_1728	3.467e-44	169.0	COG2374@1|root,COG2374@2|Bacteria,1GHB9@1117|Cyanobacteria	1117|Cyanobacteria	G	Endonuclease Exonuclease phosphatase	-	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	DUF5017,Endonuclease_1,Exo_endo_phos,LTD
HKD1_k127_4373568_0	396588.Tgr7_0968	1.395e-140	464.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD1_k127_4373568_2	105559.Nwat_1834	5.462e-91	310.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,1RP84@1236|Gammaproteobacteria,1WXJR@135613|Chromatiales	135613|Chromatiales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD1_k127_4373568_1	519989.ECTPHS_06962	4.208e-122	401.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,1RR2F@1236|Gammaproteobacteria,1WXB7@135613|Chromatiales	135613|Chromatiales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD1_k127_4373568_4	765914.ThisiDRAFT_1466	3.424e-48	179.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,1S5W5@1236|Gammaproteobacteria,1WY2F@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_4373568_3	519989.ECTPHS_06972	3.37e-72	245.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,1RMDD@1236|Gammaproteobacteria,1WVW2@135613|Chromatiales	135613|Chromatiales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_4390132_6	247634.GPB2148_3609	1.206e-35	137.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1J4E3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	Transcriptional regulator	cysB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008150,GO:0009314,GO:0009628,GO:0010165,GO:0010212,GO:0042802,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0097159,GO:1901363	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4390132_2	1173022.Cri9333_3411	7.44e-105	344.0	COG0225@1|root,COG0225@2|Bacteria,1G1QF@1117|Cyanobacteria,1H72I@1150|Oscillatoriales	1117|Cyanobacteria	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD1_k127_4390132_5	243233.MCA1564	1.43e-51	201.0	2DM5E@1|root,31SVN@2|Bacteria,1MYKR@1224|Proteobacteria,1SF2N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4340)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4340
HKD1_k127_4390132_3	557598.LHK_01013	8.107e-84	282.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,2VJCP@28216|Betaproteobacteria,2KQAQ@206351|Neisseriales	206351|Neisseriales	S	Psort location CytoplasmicMembrane, score 10.00	dedA	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD1_k127_4390132_0	396588.Tgr7_2295	0.0	1478.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,1RMS9@1236|Gammaproteobacteria,1WX68@135613|Chromatiales	135613|Chromatiales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_4390132_4	1123279.ATUS01000006_gene3359	5.664e-58	209.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,1S3WP@1236|Gammaproteobacteria,1J5PI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD1_k127_4390132_8	330214.NIDE2499	3.24e-08	57.0	2EQJE@1|root,33I5F@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2281)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2281
HKD1_k127_4390132_1	1469245.JFBG01000054_gene2100	1.719e-159	512.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,1T236@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_4390132_7	1265313.HRUBRA_02745	3.598e-35	136.0	COG3228@1|root,COG3228@2|Bacteria,1RAHF@1224|Proteobacteria,1RZQU@1236|Gammaproteobacteria,1J70R@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Belongs to the MtfA family	mtfA	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006355,GO:0006508,GO:0006807,GO:0008134,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0009889,GO:0010468,GO:0010556,GO:0016787,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031326,GO:0043170,GO:0043433,GO:0044092,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0048519,GO:0050789,GO:0050794,GO:0051090,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0065009,GO:0070011,GO:0071704,GO:0080090,GO:0140096,GO:1901564,GO:1903506,GO:2000112,GO:2001141	-	ko:K09933	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_M90
HKD1_k127_4394994_0	867903.ThesuDRAFT_00878	7.78e-157	505.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD1_k127_4394994_1	1239962.C943_03747	2.347e-20	92.0	COG2764@1|root,COG2764@2|Bacteria,4NSNJ@976|Bacteroidetes,47XP0@768503|Cytophagia	976|Bacteroidetes	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HKD1_k127_4416554_1	1454004.AW11_01667	7.855e-141	452.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria	1224|Proteobacteria	I	Dehydratase	MA20_00775	-	4.2.1.148,4.2.1.56	ko:K14449,ko:K18290	ko00630,ko00660,ko00720,ko01120,ko01200,map00630,map00660,map00720,map01120,map01200	M00373,M00376,M00740	R02491,R05076	RC00730,RC01984	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HKD1_k127_4416554_0	522306.CAP2UW1_2499	3.553e-308	956.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2VIT2@28216|Betaproteobacteria,1KQE9@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	I	Methylmalonyl-CoA mutase	icmF	-	5.4.99.2,5.4.99.63,5.4.99.64	ko:K01847,ko:K01848,ko:K14447,ko:K20906	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833,R09292	RC00395,RC02835	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD1_k127_4419842_15	1163617.SCD_n02759	3.787e-10	61.0	COG0304@1|root,COG0304@2|Bacteria,1N91E@1224|Proteobacteria,2VJR3@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	Belongs to the beta-ketoacyl-ACP synthases family	fabB	-	2.3.1.179,2.3.1.41	ko:K00647,ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_4419842_8	1209072.ALBT01000030_gene2273	7.424e-65	231.0	COG0304@1|root,COG0304@2|Bacteria,1NP8M@1224|Proteobacteria,1S4JR@1236|Gammaproteobacteria,1FHM0@10|Cellvibrio	1236|Gammaproteobacteria	IQ	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ketoacyl-synt_2
HKD1_k127_4419842_4	159087.Daro_4188	5.921e-98	325.0	COG1028@1|root,COG1028@2|Bacteria,1MUPY@1224|Proteobacteria,2VK19@28216|Betaproteobacteria,2KV3V@206389|Rhodocyclales	206389|Rhodocyclales	IQ	NAD dependent epimerase/dehydratase family	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short
HKD1_k127_4419842_7	1249627.D779_0368	9.811e-72	251.0	COG1216@1|root,COG1216@2|Bacteria,1QVEM@1224|Proteobacteria,1T2CN@1236|Gammaproteobacteria,1WYAF@135613|Chromatiales	135613|Chromatiales	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_4419842_12	1121451.DESAM_21150	7.095e-33	132.0	2E65Y@1|root,330UM@2|Bacteria,1N8U3@1224|Proteobacteria,42VZJ@68525|delta/epsilon subdivisions,2WYHB@28221|Deltaproteobacteria,2MDIX@213115|Desulfovibrionales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4419842_6	426114.THI_2615	1.185e-78	271.0	COG3713@1|root,COG3713@2|Bacteria,1R5JE@1224|Proteobacteria,2VKVW@28216|Betaproteobacteria,1KKV7@119065|unclassified Burkholderiales	28216|Betaproteobacteria	M	MltA-interacting protein MipA	-	-	-	-	-	-	-	-	-	-	-	-	MipA
HKD1_k127_4419842_5	1116472.MGMO_138c00130	2.311e-90	305.0	COG0726@1|root,COG0726@2|Bacteria,1PGPG@1224|Proteobacteria,1SPJC@1236|Gammaproteobacteria,1XGNN@135618|Methylococcales	135618|Methylococcales	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_4419842_2	395493.BegalDRAFT_1675	2.467e-116	381.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,1RNEJ@1236|Gammaproteobacteria,462KM@72273|Thiotrichales	72273|Thiotrichales	H	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.25,4.1.3.34	ko:K01644,ko:K18292	ko00660,ko01100,ko02020,map00660,map01100,map02020	-	R00237,R00362	RC00067,RC00502,RC01118,RC01205	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_4419842_1	713586.KB900536_gene753	1.515e-138	446.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,1RMC5@1236|Gammaproteobacteria,1WWXT@135613|Chromatiales	135613|Chromatiales	V	PFAM ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4419842_0	391615.ABSJ01000022_gene309	3.23e-191	627.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1J4C2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	ykoW	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_4419842_9	521045.Kole_0111	7.817e-54	216.0	COG3437@1|root,COG3437@2|Bacteria,2GEHV@200918|Thermotogae	2|Bacteria	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5,PAS,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_4419842_11	105559.Nwat_1386	3.518e-40	150.0	COG1662@1|root,COG1662@2|Bacteria,1RAS6@1224|Proteobacteria,1S34C@1236|Gammaproteobacteria,1X1FD@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	insB	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
HKD1_k127_4419842_13	272134.KB731324_gene927	7.712e-15	75.0	COG1662@1|root,COG3677@1|root,COG1662@2|Bacteria,COG3677@2|Bacteria,1G7DC@1117|Cyanobacteria,1HCUJ@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1,HTH_Tnp_IS1,Zn_Tnp_IS1
HKD1_k127_4419842_14	272134.KB731324_gene6644	1.189e-12	70.0	COG3677@1|root,COG3677@2|Bacteria,1GEJ0@1117|Cyanobacteria,1HFYP@1150|Oscillatoriales	1117|Cyanobacteria	L	InsA C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_IS1,Zn_Tnp_IS1
HKD1_k127_4419842_10	521045.Kole_1016	2.608e-42	158.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	divK	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD1_k127_4419842_3	1210884.HG799466_gene12819	4.807e-108	367.0	COG5002@1|root,COG5002@2|Bacteria,2IXHW@203682|Planctomycetes	203682|Planctomycetes	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9
HKD1_k127_4437016_0	439496.RBY4I_316	1.056e-103	368.0	COG3598@1|root,COG4643@1|root,COG3598@2|Bacteria,COG4643@2|Bacteria,1R6M4@1224|Proteobacteria,2U1V0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Core component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. Binds to DNA. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	PriCT_2,Prim-Pol
HKD1_k127_4437016_2	526225.Gobs_1978	1.025e-23	118.0	COG0358@1|root,COG0358@2|Bacteria,2I620@201174|Actinobacteria	201174|Actinobacteria	L	Protein of unknown function (DUF3987)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3987,Toprim_3
HKD1_k127_4437016_1	1244869.H261_22143	2.559e-59	212.0	2BNSJ@1|root,32HG4@2|Bacteria,1MV5R@1224|Proteobacteria,2U1AN@28211|Alphaproteobacteria,2JT39@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HKD1_k127_445365_2	502025.Hoch_5086	9.062e-78	282.0	COG0715@1|root,COG2885@1|root,COG0715@2|Bacteria,COG2885@2|Bacteria,1R687@1224|Proteobacteria,42ZCB@68525|delta/epsilon subdivisions,2WTSU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	MP	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1,OmpA
HKD1_k127_445365_0	365044.Pnap_3261	2.339e-146	503.0	2DBIA@1|root,2Z9FA@2|Bacteria,1N8X6@1224|Proteobacteria,2VXGK@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Tubulin_2
HKD1_k127_445365_4	314278.NB231_00420	1.758e-14	76.0	COG0493@1|root,COG0543@1|root,COG0493@2|Bacteria,COG0543@2|Bacteria,1PE6F@1224|Proteobacteria,1RWQP@1236|Gammaproteobacteria,1X0D0@135613|Chromatiales	135613|Chromatiales	CEH	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_445365_1	211165.AJLN01000049_gene6077	4.129e-79	269.0	COG4636@1|root,COG4636@2|Bacteria,1GKRJ@1117|Cyanobacteria,1JMM4@1189|Stigonemataceae	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_445365_3	641526.ADIWIN_2447	4.752e-15	85.0	COG1816@1|root,COG1816@2|Bacteria,4NINN@976|Bacteroidetes,1I83N@117743|Flavobacteriia	976|Bacteroidetes	F	Adenosine/AMP deaminase	-	-	-	-	-	-	-	-	-	-	-	-	A_deaminase
HKD1_k127_4463372_1	187272.Mlg_2191	1.2e-73	252.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,1RNXK@1236|Gammaproteobacteria,1WW8T@135613|Chromatiales	135613|Chromatiales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD1_k127_4463372_0	519989.ECTPHS_01889	6.037e-124	404.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,1RMTM@1236|Gammaproteobacteria,1WWYB@135613|Chromatiales	135613|Chromatiales	M	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_4463372_2	105559.Nwat_0231	0.0006281	49.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria,1X2GI@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD1_k127_4471386_1	323261.Noc_0885	8.282e-99	329.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,1RM8D@1236|Gammaproteobacteria,1WWMY@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD1_k127_4471386_0	572477.Alvin_2756	9.478e-106	350.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,1RMEG@1236|Gammaproteobacteria,1WW2E@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD1_k127_4471386_2	1123392.AQWL01000002_gene1981	2.096e-61	220.0	COG2717@1|root,COG2717@2|Bacteria,1RDUP@1224|Proteobacteria,2VRBQ@28216|Betaproteobacteria,1KSU5@119069|Hydrogenophilales	119069|Hydrogenophilales	C	Ferric reductase like transmembrane component	-	-	-	-	-	-	-	-	-	-	-	-	Ferric_reduct
HKD1_k127_4480204_0	396588.Tgr7_1129	4.722e-225	710.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,1RMBN@1236|Gammaproteobacteria,1WWJ6@135613|Chromatiales	135613|Chromatiales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_4480204_4	1234364.AMSF01000015_gene3139	8.051e-15	76.0	COG0599@1|root,COG0599@2|Bacteria,1MZ80@1224|Proteobacteria,1SA74@1236|Gammaproteobacteria,1X7IZ@135614|Xanthomonadales	135614|Xanthomonadales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_4480204_3	1123502.AQXD01000003_gene1378	2.882e-43	169.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S8R3@1236|Gammaproteobacteria,1XC67@135614|Xanthomonadales	135614|Xanthomonadales	M	transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124,SLT
HKD1_k127_4480204_2	748280.NH8B_3129	7.344e-46	174.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,2VKFN@28216|Betaproteobacteria,2KRK4@206351|Neisseriales	206351|Neisseriales	M	Transglycosylase SLT domain	slt	-	3.2.1.17	ko:K01185	-	-	-	-	ko00000,ko01000	-	-	-	DUF4124,SLT
HKD1_k127_4480204_1	269799.Gmet_0133	1.959e-115	381.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_4508853_2	1279019.ARQK01000036_gene1616	2.583e-70	240.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,1S1Z3@1236|Gammaproteobacteria,1WYAE@135613|Chromatiales	135613|Chromatiales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_4508853_0	472759.Nhal_1092	2.486e-152	489.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD1_k127_4508853_3	105559.Nwat_0768	2.251e-43	168.0	COG3063@1|root,COG3063@2|Bacteria,1MXPC@1224|Proteobacteria,1RY78@1236|Gammaproteobacteria,1WWUQ@135613|Chromatiales	135613|Chromatiales	NU	TIGRFAM type IV pilus biogenesis stability protein PilW	-	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	LysM,TPR_10,TPR_14,TPR_16,TPR_17,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HKD1_k127_4508853_4	1283284.AZUK01000001_gene2383	6.872e-23	111.0	COG1426@1|root,COG1426@2|Bacteria,1N240@1224|Proteobacteria,1RQMV@1236|Gammaproteobacteria,1Y4HP@135624|Aeromonadales	135624|Aeromonadales	S	Domain of unknown function (DUF4115)	-	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	DUF4115,HTH_25
HKD1_k127_4508853_1	1397528.Q671_14105	1.584e-115	377.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1XIK3@135619|Oceanospirillales	135619|Oceanospirillales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_4523403_4	1304883.KI912532_gene1737	4.637e-31	125.0	COG1116@1|root,COG1116@2|Bacteria,1MUDV@1224|Proteobacteria,2VJXH@28216|Betaproteobacteria,2KU9N@206389|Rhodocyclales	206389|Rhodocyclales	P	COG1116 ABC-type nitrate sulfonate bicarbonate transport system, ATPase component	nasD	-	-	ko:K15578	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16.1	-	-	ABC_tran
HKD1_k127_4523403_1	1163617.SCD_n02262	1.975e-127	417.0	COG0600@1|root,COG0600@2|Bacteria,1MU6Q@1224|Proteobacteria,2VH12@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Nitrate ABC transporter inner membrane subunit	nasE	-	-	ko:K15577	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	BPD_transp_1
HKD1_k127_4523403_0	582744.Msip34_0354	2.836e-206	649.0	COG0715@1|root,COG0715@2|Bacteria,1MWDN@1224|Proteobacteria,2VIJH@28216|Betaproteobacteria,2KKIU@206350|Nitrosomonadales	206350|Nitrosomonadales	P	NMT1-like family	-	-	-	ko:K15576	ko00910,ko02010,map00910,map02010	M00438	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16.1,3.A.1.16.2	-	-	NMT1_2
HKD1_k127_4523403_3	395493.BegalDRAFT_1387	3.673e-65	228.0	COG3707@1|root,COG3707@2|Bacteria,1MXDV@1224|Proteobacteria,1S3YY@1236|Gammaproteobacteria,4611P@72273|Thiotrichales	72273|Thiotrichales	T	PFAM response regulator receiver	-	-	-	ko:K07183	-	-	-	-	ko00000,ko02022	-	-	-	ANTAR,Response_reg
HKD1_k127_4523403_2	105559.Nwat_1970	3.889e-70	243.0	COG0664@1|root,COG0664@2|Bacteria,1MXID@1224|Proteobacteria,1S5PP@1236|Gammaproteobacteria,1WYN6@135613|Chromatiales	135613|Chromatiales	K	SMART cyclic nucleotide-binding	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_45285_0	1469607.KK073769_gene6235	9.387e-65	231.0	COG2433@1|root,COG2433@2|Bacteria,1G2BH@1117|Cyanobacteria,1HRA7@1161|Nostocales	1117|Cyanobacteria	S	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_45285_1	395019.Bmul_3319	2.063e-52	194.0	COG3917@1|root,COG3917@2|Bacteria,1RJFB@1224|Proteobacteria,2VPYN@28216|Betaproteobacteria,1K3J6@119060|Burkholderiaceae	28216|Betaproteobacteria	Q	2-hydroxychromene-2-carboxylate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD1_k127_45285_2	87626.PTD2_07869	3.056e-09	60.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,1S8W0@1236|Gammaproteobacteria,2Q359@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	GO:0003674,GO:0003676,GO:0003677,GO:0003681,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006378,GO:0006396,GO:0006397,GO:0006417,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010608,GO:0010628,GO:0010629,GO:0016043,GO:0016070,GO:0016071,GO:0016246,GO:0016441,GO:0016458,GO:0017148,GO:0019222,GO:0022607,GO:0022613,GO:0022618,GO:0030423,GO:0031047,GO:0031123,GO:0031124,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0032268,GO:0032269,GO:0032270,GO:0034248,GO:0034249,GO:0034250,GO:0034622,GO:0034641,GO:0035194,GO:0040029,GO:0040033,GO:0043170,GO:0043631,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0045727,GO:0045974,GO:0045975,GO:0046483,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051173,GO:0051246,GO:0051247,GO:0051248,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071826,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:2000112,GO:2000113	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD1_k127_45285_3	765911.Thivi_1711	0.0002003	45.0	COG0500@1|root,COG0500@2|Bacteria,1MVFJ@1224|Proteobacteria,1RY0W@1236|Gammaproteobacteria,1WW5J@135613|Chromatiales	135613|Chromatiales	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4554984_0	748247.AZKH_1971	9.2e-116	380.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_4554984_1	1194165.CAJF01000022_gene3107	2.641e-83	295.0	COG0659@1|root,COG0659@2|Bacteria,2GJCB@201174|Actinobacteria,4FN4H@85023|Microbacteriaceae	201174|Actinobacteria	P	STAS domain	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD1_k127_4565562_14	1541065.JRFE01000073_gene3320	3.203e-07	51.0	COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria,3VMW4@52604|Pleurocapsales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD1_k127_4565562_11	472759.Nhal_1628	1.085e-18	87.0	COG1662@1|root,COG1662@2|Bacteria,1RICT@1224|Proteobacteria,1T2YD@1236|Gammaproteobacteria,1X23H@135613|Chromatiales	1236|Gammaproteobacteria	L	PFAM IS1 transposase	-	-	-	ko:K07480	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS1
HKD1_k127_4565562_12	631362.Thi970DRAFT_04572	2.034e-17	85.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RP5P@1236|Gammaproteobacteria,1WXEY@135613|Chromatiales	135613|Chromatiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_4565562_10	1255043.TVNIR_2409	1.618e-19	95.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RP5P@1236|Gammaproteobacteria,1WXEY@135613|Chromatiales	135613|Chromatiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_4565562_8	489825.LYNGBM3L_23890	2.065e-66	235.0	28HHG@1|root,2ZASK@2|Bacteria,1G3W2@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4565562_13	195250.CM001776_gene2552	3.558e-15	78.0	COG2433@1|root,COG2433@2|Bacteria,1G2BH@1117|Cyanobacteria	1117|Cyanobacteria	P	PFAM transposase IS66	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_4565562_7	582899.Hden_0489	1.554e-91	309.0	COG3394@1|root,COG3394@2|Bacteria,1PP39@1224|Proteobacteria,2U2UW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	hopanoid biosynthesis associated protein HpnK	-	-	3.5.1.105	ko:K03478	-	-	-	-	ko00000,ko01000	-	-	-	YdjC
HKD1_k127_4565562_6	497965.Cyan7822_4484	2.408e-112	368.0	COG1633@1|root,COG1633@2|Bacteria,1G252@1117|Cyanobacteria,3KHUI@43988|Cyanothece	1117|Cyanobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4565562_1	1173023.KE650771_gene5179	5.791e-282	870.0	COG1032@1|root,COG1032@2|Bacteria,1G3ZK@1117|Cyanobacteria,1JKRV@1189|Stigonemataceae	1117|Cyanobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,Radical_SAM
HKD1_k127_4565562_4	243231.GSU0368	1.643e-172	549.0	COG0729@1|root,COG0729@2|Bacteria,1QXN0@1224|Proteobacteria,43C43@68525|delta/epsilon subdivisions,2X7EI@28221|Deltaproteobacteria,43TF9@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD1_k127_4565562_2	765913.ThidrDRAFT_0666	1.048e-231	726.0	COG0147@1|root,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,1RMSE@1236|Gammaproteobacteria,1WX6V@135613|Chromatiales	135613|Chromatiales	E	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_4565562_9	105559.Nwat_0641	6.802e-66	231.0	COG0546@1|root,COG0546@2|Bacteria,1RDDY@1224|Proteobacteria,1S3QD@1236|Gammaproteobacteria,1WWPE@135613|Chromatiales	135613|Chromatiales	G	HAD-superfamily hydrolase, subfamily IA, variant 3	gph	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_4565562_5	395493.BegalDRAFT_0979	7.077e-124	400.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,1RN3K@1236|Gammaproteobacteria,46063@72273|Thiotrichales	72273|Thiotrichales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_4565562_3	1333998.M2A_3085	2.738e-215	683.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,4BPW2@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	V	ABC transporter transmembrane region	msbA2	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_4565562_0	378806.STAUR_7835	0.0	1561.0	COG0514@1|root,COG0550@1|root,COG0514@2|Bacteria,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,42NQG@68525|delta/epsilon subdivisions,2WJXC@28221|Deltaproteobacteria,2YU8A@29|Myxococcales	28221|Deltaproteobacteria	L	ATP-dependent DNA helicase RecQ	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	DEAD,HRDC,Helicase_C,RecQ_Zn_bind,Topoisom_bac,Toprim,Toprim_Crpt,zf-C4_Topoisom
HKD1_k127_4565562_16	1479237.JMLY01000001_gene2558	0.0005216	51.0	2DQ8R@1|root,335B4@2|Bacteria,1N91K@1224|Proteobacteria,1SE1Z@1236|Gammaproteobacteria,46CBQ@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HKD1_k127_4565562_15	402881.Plav_3107	0.000307	45.0	COG2079@1|root,COG2079@2|Bacteria,1R5UM@1224|Proteobacteria,2U1F8@28211|Alphaproteobacteria,1JP1J@119043|Rhodobiaceae	28211|Alphaproteobacteria	S	MmgE/PrpD family	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_4577328_2	1056820.KB900699_gene1210	2.47e-54	194.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,1RM92@1236|Gammaproteobacteria,2PN2G@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	F	CTP synthase N-terminus	pyrG	GO:0003674,GO:0003824,GO:0003883,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006213,GO:0006220,GO:0006221,GO:0006241,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009208,GO:0009209,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046036,GO:0046131,GO:0046132,GO:0046134,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iECO103_1326.ECO103_3323,iPC815.YPO3377	CTP_synth_N,GATase
HKD1_k127_4577328_1	246195.DNO_0414	2.057e-56	203.0	COG0503@1|root,COG0503@2|Bacteria,1MVZ6@1224|Proteobacteria,1S2N9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD1_k127_4577328_0	187272.Mlg_1037	6.044e-120	397.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_4588773_6	395493.BegalDRAFT_1114	2.743e-22	99.0	COG1168@1|root,COG1168@2|Bacteria,1MY33@1224|Proteobacteria,1RP58@1236|Gammaproteobacteria,460EN@72273|Thiotrichales	72273|Thiotrichales	E	PFAM Aminotransferase class I and II	-	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_4588773_2	519989.ECTPHS_09333	8.475e-77	262.0	COG0535@1|root,COG0535@2|Bacteria,1QUQ6@1224|Proteobacteria,1T20T@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_4588773_1	102125.Xen7305DRAFT_00036000	2.938e-79	272.0	COG0584@1|root,COG0584@2|Bacteria,1GJ0N@1117|Cyanobacteria,3VM2E@52604|Pleurocapsales	1117|Cyanobacteria	C	Glycerophosphoryl diester phosphodiesterase family	-	-	-	-	-	-	-	-	-	-	-	-	GDPD
HKD1_k127_4588773_4	469371.Tbis_1348	2.218e-32	138.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2HU8H@201174|Actinobacteria,4EDMS@85010|Pseudonocardiales	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_4588773_3	1278309.KB907100_gene2068	1.658e-57	206.0	COG2030@1|root,COG2030@2|Bacteria,1MWPK@1224|Proteobacteria,1S92X@1236|Gammaproteobacteria,1XK77@135619|Oceanospirillales	135619|Oceanospirillales	I	dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HKD1_k127_4588773_0	396588.Tgr7_1534	2.023e-134	437.0	COG0182@1|root,COG0182@2|Bacteria,1MUPM@1224|Proteobacteria,1RMGC@1236|Gammaproteobacteria,1WWQU@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD1_k127_4588773_5	1000565.METUNv1_03444	7.912e-31	123.0	COG0745@1|root,COG0745@2|Bacteria,1RBJ1@1224|Proteobacteria,2VMZX@28216|Betaproteobacteria,2KW4A@206389|Rhodocyclales	206389|Rhodocyclales	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4598253_8	395494.Galf_1140	1.867e-06	51.0	COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
HKD1_k127_4598253_10	522306.CAP2UW1_1772	4.291e-05	52.0	COG3385@1|root,COG3385@2|Bacteria,1R807@1224|Proteobacteria,2W0D8@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
HKD1_k127_4598253_6	1232410.KI421428_gene1091	2.09e-27	117.0	COG3440@1|root,COG3440@2|Bacteria,1NE0N@1224|Proteobacteria,42RDP@68525|delta/epsilon subdivisions,2WMZC@28221|Deltaproteobacteria,43TG8@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	HNH endonuclease	-	-	-	ko:K07454	-	-	-	-	ko00000	-	-	-	HNH_2
HKD1_k127_4598253_4	358220.C380_14610	2.357e-56	199.0	COG0537@1|root,COG0537@2|Bacteria,1N3EA@1224|Proteobacteria,2VSGA@28216|Betaproteobacteria,4AJE5@80864|Comamonadaceae	28216|Betaproteobacteria	FG	Scavenger mRNA decapping enzyme C-term binding	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HKD1_k127_4598253_11	335659.S23_57390	4.968e-05	51.0	COG3093@1|root,COG3093@2|Bacteria,1PZ90@1224|Proteobacteria,2UZYZ@28211|Alphaproteobacteria,3K555@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	addiction module antidote protein HigA	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4598253_3	1286106.MPL1_09185	8.156e-60	222.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,1RMFM@1236|Gammaproteobacteria,4608R@72273|Thiotrichales	72273|Thiotrichales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_4598253_1	118166.JH976537_gene3692	2.11e-103	344.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria,1H7UZ@1150|Oscillatoriales	1117|Cyanobacteria	C	PFAM Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
HKD1_k127_4598253_2	264198.Reut_B3680	1.407e-70	250.0	COG4257@1|root,COG4257@2|Bacteria,1R448@1224|Proteobacteria,2W139@28216|Betaproteobacteria,1KEAH@119060|Burkholderiaceae	28216|Betaproteobacteria	V	Carboxypeptidase regulatory-like domain	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	CarboxypepD_reg
HKD1_k127_4598253_7	768066.HELO_3004	2.436e-08	61.0	COG0406@1|root,COG0406@2|Bacteria,1N1NR@1224|Proteobacteria,1SBM5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD1_k127_4598253_9	1150469.RSPPHO_02781	2.301e-05	49.0	COG2165@1|root,COG2165@2|Bacteria,1PJ5F@1224|Proteobacteria,2VC7I@28211|Alphaproteobacteria,2JY2W@204441|Rhodospirillales	204441|Rhodospirillales	NU	general secretion pathway protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4598253_5	583345.Mmol_0398	1.493e-31	130.0	COG4654@1|root,COG4654@2|Bacteria,1N6UN@1224|Proteobacteria,2VW1Y@28216|Betaproteobacteria,2KMZ0@206350|Nitrosomonadales	206350|Nitrosomonadales	C	PFAM cytochrome c, class I	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_4598253_0	765911.Thivi_2456	2.556e-122	421.0	COG4223@1|root,COG4223@2|Bacteria,1NDYH@1224|Proteobacteria,1SKYF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4634767_0	1123508.JH636440_gene2559	2.491e-70	252.0	2EZN7@1|root,33ST8@2|Bacteria,2J2CB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4634767_1	1123508.JH636440_gene2560	5.664e-30	124.0	2BYEG@1|root,349F2@2|Bacteria,2J42U@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4634767_3	1274524.BSONL12_22960	1.875e-07	59.0	2F8ST@1|root,3414Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4662657_2	1123376.AUIU01000011_gene1021	7.882e-48	177.0	COG0494@1|root,COG0494@2|Bacteria,3J0TN@40117|Nitrospirae	40117|Nitrospirae	L	NUDIX domain	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_4662657_1	243231.GSU2697	2.538e-177	564.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,42NHV@68525|delta/epsilon subdivisions,2WJBA@28221|Deltaproteobacteria,43T2U@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	acrA	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,HlyD_D23
HKD1_k127_4662657_0	316067.Geob_1226	5.802e-267	827.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,43TUU@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	TIGRFAM transporter, hydrophobe amphiphile efflux-1 (HAE1) family	acrB	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4674845_1	1392491.JIAE01000001_gene2138	4.6e-42	163.0	COG1893@1|root,COG1893@2|Bacteria,1UM1M@1239|Firmicutes,249J4@186801|Clostridia,3WM5D@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_4674845_2	472759.Nhal_1492	4.261e-11	76.0	COG1262@1|root,COG1672@1|root,COG1262@2|Bacteria,COG1672@2|Bacteria,1RAMU@1224|Proteobacteria,1S87Q@1236|Gammaproteobacteria,1X2AR@135613|Chromatiales	135613|Chromatiales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_4674845_0	261292.Nit79A3_0088	4.21e-153	509.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria,2W0EW@28216|Betaproteobacteria	28216|Betaproteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
HKD1_k127_4700792_1	187272.Mlg_2229	4.423e-97	325.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,1WW0D@135613|Chromatiales	135613|Chromatiales	S	PFAM ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4700792_4	1333856.L686_20735	3.812e-27	121.0	COG1934@1|root,COG1934@2|Bacteria,1N776@1224|Proteobacteria,1RPM7@1236|Gammaproteobacteria,1YZTW@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm	lptA	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0006869,GO:0008150,GO:0009279,GO:0010876,GO:0015920,GO:0016020,GO:0017089,GO:0019867,GO:0030288,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0042597,GO:0042802,GO:0044462,GO:0044464,GO:0046836,GO:0051179,GO:0051234,GO:0071702,GO:0071944,GO:1901264	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	iB21_1397.B21_03016,iECBD_1354.ECBD_0542,iECB_1328.ECB_03065,iECD_1391.ECD_03065	OstA
HKD1_k127_4700792_5	519989.ECTPHS_01694	7.479e-11	70.0	COG3117@1|root,COG3117@2|Bacteria,1NGCC@1224|Proteobacteria	1224|Proteobacteria	S	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA	lptC	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HKD1_k127_4700792_3	1286106.MPL1_03328	9.948e-64	224.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,460SA@72273|Thiotrichales	72273|Thiotrichales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD1_k127_4700792_0	472759.Nhal_0339	2.868e-141	455.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,1RMT9@1236|Gammaproteobacteria,1WWFJ@135613|Chromatiales	135613|Chromatiales	M	Arabinose 5-phosphate isomerase	-	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD1_k127_4700792_2	1005048.CFU_1188	3.261e-83	279.0	COG0642@1|root,COG2205@2|Bacteria,1MUAK@1224|Proteobacteria,2WGJC@28216|Betaproteobacteria,472IH@75682|Oxalobacteraceae	28216|Betaproteobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c
HKD1_k127_4703029_0	697282.Mettu_3176	8.575e-252	781.0	COG1049@1|root,COG1049@2|Bacteria,1MVCR@1224|Proteobacteria,1RNMC@1236|Gammaproteobacteria,1XDTE@135618|Methylococcales	135618|Methylococcales	C	Belongs to the aconitase IPM isomerase family	-	-	4.2.1.3,4.2.1.99	ko:K01682	ko00020,ko00630,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173	R01324,R01325,R01900,R04425	RC00497,RC00498,RC00618,RC01153	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_2_N,Aconitase_B_N
HKD1_k127_4703029_6	717774.Marme_0264	3.412e-58	205.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,1S3QK@1236|Gammaproteobacteria,1XJJW@135619|Oceanospirillales	135619|Oceanospirillales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD1_k127_4703029_2	713586.KB900536_gene1145	7.758e-146	468.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,1RMU3@1236|Gammaproteobacteria,1WWB2@135613|Chromatiales	135613|Chromatiales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD1_k127_4703029_3	1158150.KB906243_gene1869	4.442e-96	317.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,1RQ38@1236|Gammaproteobacteria,1WW34@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD1_k127_4703029_5	765912.Thimo_2836	2.691e-67	230.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,1S3Q2@1236|Gammaproteobacteria,1WYDZ@135613|Chromatiales	135613|Chromatiales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD1_k127_4703029_8	472759.Nhal_2407	6.949e-53	188.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,1S3NX@1236|Gammaproteobacteria,1WYHF@135613|Chromatiales	135613|Chromatiales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_4703029_12	105559.Nwat_2137	1.547e-13	70.0	COG0257@1|root,COG0257@2|Bacteria,1NGEI@1224|Proteobacteria,1SGC9@1236|Gammaproteobacteria,1WZNA@135613|Chromatiales	135613|Chromatiales	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD1_k127_4703029_1	396588.Tgr7_2304	4.842e-219	686.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,1RNJV@1236|Gammaproteobacteria,1WWJA@135613|Chromatiales	135613|Chromatiales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD1_k127_4703029_7	395493.BegalDRAFT_2605	1.056e-56	201.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,1S3P6@1236|Gammaproteobacteria,460T4@72273|Thiotrichales	72273|Thiotrichales	J	binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD1_k127_4703029_11	1123517.JOMR01000001_gene1864	4.061e-22	97.0	COG1841@1|root,COG1841@2|Bacteria,1N6ZE@1224|Proteobacteria,1SC8N@1236|Gammaproteobacteria,4617P@72273|Thiotrichales	72273|Thiotrichales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD1_k127_4703029_4	187272.Mlg_0475	5.043e-73	249.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,1RNEV@1236|Gammaproteobacteria,1WX2D@135613|Chromatiales	135613|Chromatiales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD1_k127_4703029_9	519989.ECTPHS_13138	4.251e-46	168.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,1S5V2@1236|Gammaproteobacteria,1WZ44@135613|Chromatiales	135613|Chromatiales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD1_k127_4703029_10	380394.Lferr_0512	6.601e-25	104.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,1S1Z1@1236|Gammaproteobacteria,2NCNP@225057|Acidithiobacillales	225057|Acidithiobacillales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD1_k127_4704908_13	105559.Nwat_2421	3.744e-10	61.0	COG5606@1|root,COG5606@2|Bacteria,1N7ZQ@1224|Proteobacteria,1SFHF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HKD1_k127_4704908_8	317619.ANKN01000039_gene61	3.601e-39	151.0	COG4636@1|root,COG4636@2|Bacteria,1GGUY@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4704908_5	1121440.AUMA01000006_gene1566	2.295e-162	520.0	COG2211@1|root,COG2211@2|Bacteria,1QVH9@1224|Proteobacteria	1224|Proteobacteria	G	Pfam Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_4704908_6	98439.AJLL01000089_gene3796	2.065e-45	175.0	COG1689@1|root,COG1689@2|Bacteria	2|Bacteria	S	PFAM Prenyltransferase squalene oxidase	-	-	2.5.1.60	ko:K05956	-	-	-	-	ko00000,ko01000,ko01006,ko04131	-	-	-	Prenyltrans
HKD1_k127_4704908_1	765913.ThidrDRAFT_0887	1.969e-214	672.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RQ8R@1236|Gammaproteobacteria,1X0DR@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	-	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_4704908_9	1121440.AUMA01000006_gene1558	1.088e-37	145.0	COG0589@1|root,COG0589@2|Bacteria,1RA7K@1224|Proteobacteria,42V2P@68525|delta/epsilon subdivisions,2WR88@28221|Deltaproteobacteria,2MDMW@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4704908_3	113395.AXAI01000012_gene7132	1.346e-183	581.0	COG0475@1|root,COG0475@2|Bacteria,1R7K4@1224|Proteobacteria,2U29N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_4704908_11	1056495.Calag_0061	2.327e-25	111.0	COG0537@1|root,arCOG00419@2157|Archaea	2157|Archaea	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family	-	-	2.5.1.3,2.7.7.53	ko:K02503,ko:K19710,ko:K21220	ko00230,ko00730,ko01100,map00230,map00730,map01100	-	R00126,R01618,R03223,R10712	RC00002,RC00224,RC02753,RC02795,RC03255,RC03397	ko00000,ko00001,ko01000,ko04147	-	-	-	HIT,ThiP_synth
HKD1_k127_4704908_10	1288494.EBAPG3_15510	3.135e-35	144.0	COG1993@1|root,COG1993@2|Bacteria,1RH30@1224|Proteobacteria,2WFX5@28216|Betaproteobacteria,373EV@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Uncharacterized ACR, COG1993	-	-	-	-	-	-	-	-	-	-	-	-	DUF190
HKD1_k127_4704908_7	1163617.SCD_n01459	2.536e-44	166.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2VUBZ@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD1_k127_4704908_4	1111732.AZOD01000005_gene876	4.017e-163	518.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,1RMAX@1236|Gammaproteobacteria,1X3NI@135614|Xanthomonadales	135614|Xanthomonadales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006091,GO:0006099,GO:0006101,GO:0006107,GO:0006108,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009060,GO:0009117,GO:0009987,GO:0015980,GO:0016491,GO:0016614,GO:0016615,GO:0016616,GO:0016999,GO:0017144,GO:0019362,GO:0019637,GO:0019674,GO:0019752,GO:0030060,GO:0034641,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046483,GO:0046496,GO:0051186,GO:0055086,GO:0055114,GO:0071704,GO:0072350,GO:0072524,GO:1901360,GO:1901564	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_4704908_0	1163617.SCD_n01505	1.787e-289	900.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2VI3T@28216|Betaproteobacteria	28216|Betaproteobacteria	I	PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A	prpE	-	6.2.1.17	ko:K01908	ko00640,ko01100,map00640,map01100	-	R00926,R01354	RC00004,RC00043,RC00070,RC02816	ko00000,ko00001,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_4704908_12	1283300.ATXB01000002_gene2750	1.79e-11	68.0	2DSB8@1|root,33FCU@2|Bacteria,1NHS8@1224|Proteobacteria,1SVYW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4704908_2	1120971.AUCA01000012_gene2570	8.338e-185	594.0	COG4934@1|root,COG4934@2|Bacteria	2|Bacteria	O	collagen metabolic process	kscP	-	-	ko:K08677	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_S8,Pro-kuma_activ
HKD1_k127_4734369_3	1070319.CAGGBEG34_770001	6.095e-30	120.0	COG1961@1|root,COG1961@2|Bacteria,1MVIE@1224|Proteobacteria,2VK01@28216|Betaproteobacteria,1K0XA@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Resolvase domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_4734369_1	398527.Bphyt_6441	3.09e-126	407.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,2VPNF@28216|Betaproteobacteria,1KGTN@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_4734369_2	398527.Bphyt_6440	1.787e-85	289.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VMEU@28216|Betaproteobacteria,1K5F3@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_4734369_0	266265.Bxe_A1791	4.183e-132	438.0	COG4584@1|root,COG4584@2|Bacteria,1MU2G@1224|Proteobacteria,2VMEU@28216|Betaproteobacteria,1K5F3@119060|Burkholderiaceae	28216|Betaproteobacteria	L	PFAM Integrase catalytic region	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_4734369_4	686340.Metal_3215	1.176e-17	87.0	COG3385@1|root,COG3385@2|Bacteria,1QFKR@1224|Proteobacteria,1SCE4@1236|Gammaproteobacteria,1XGSH@135618|Methylococcales	135618|Methylococcales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4781732_0	765911.Thivi_2127	6.059e-211	666.0	COG0535@1|root,COG1433@1|root,COG0535@2|Bacteria,COG1433@2|Bacteria,1MWDC@1224|Proteobacteria,1RRMW@1236|Gammaproteobacteria,1WWDR@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM Nitrogenase cofactor biosynthesis protein NifB	-	-	-	ko:K02585	-	-	-	-	ko00000	-	-	-	Nitro_FeMo-Co,Radical_SAM
HKD1_k127_4781732_3	1280679.ATVX01000008_gene1973	4.263e-33	140.0	COG0726@1|root,COG0726@2|Bacteria,1VDVD@1239|Firmicutes	1239|Firmicutes	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_4781732_4	1385514.N782_00030	1.918e-13	83.0	COG3153@1|root,COG3153@2|Bacteria,1V0I4@1239|Firmicutes,4HCMH@91061|Bacilli,2YB6D@289201|Pontibacillus	91061|Bacilli	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
HKD1_k127_4781732_5	388467.A19Y_3286	4.383e-10	72.0	COG2755@1|root,COG2755@2|Bacteria,1G060@1117|Cyanobacteria,1H9JP@1150|Oscillatoriales	1117|Cyanobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
HKD1_k127_4781732_2	1297742.A176_07547	3.539e-73	250.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YYA3@29|Myxococcales	28221|Deltaproteobacteria	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_4781732_1	765911.Thivi_3032	9.497e-108	354.0	COG1028@1|root,COG1028@2|Bacteria,1MUWC@1224|Proteobacteria,1RQBN@1236|Gammaproteobacteria,1WZXK@135613|Chromatiales	135613|Chromatiales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_4799155_3	572477.Alvin_0985	4.771e-126	411.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,1RMIH@1236|Gammaproteobacteria,1WW51@135613|Chromatiales	135613|Chromatiales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD1_k127_4799155_2	1049564.TevJSym_ad00110	5.905e-167	531.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,1RN22@1236|Gammaproteobacteria,1J559@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	GO:0003674,GO:0003824,GO:0004812,GO:0004826,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSSON_1240.SSON_1444,iYL1228.KPN_02176	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_4799155_10	523791.Kkor_1712	1.678e-52	187.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,1S3P3@1236|Gammaproteobacteria,1XJKA@135619|Oceanospirillales	135619|Oceanospirillales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD1_k127_4799155_13	413404.Rmag_0646	7.953e-23	98.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,1SCHI@1236|Gammaproteobacteria,1J7AC@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD1_k127_4799155_6	1123502.AQXD01000003_gene1463	1.238e-71	245.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,1S4E6@1236|Gammaproteobacteria,1X53K@135614|Xanthomonadales	135614|Xanthomonadales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD1_k127_4799155_0	395493.BegalDRAFT_3329	2.176e-316	979.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,1RMYE@1236|Gammaproteobacteria,45ZTX@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD1_k127_4799155_9	1112217.PPL19_04655	9.402e-57	206.0	COG0593@1|root,COG0593@2|Bacteria,1MVW6@1224|Proteobacteria,1RPJP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA	hda	GO:0000166,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006270,GO:0006275,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008156,GO:0009058,GO:0009059,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0017076,GO:0019219,GO:0019222,GO:0030174,GO:0030554,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034645,GO:0036094,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043531,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0045934,GO:0046483,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901363,GO:1901576,GO:2000104,GO:2000112,GO:2000113	-	ko:K10763	-	-	-	-	ko00000,ko03032	-	-	-	Bac_DnaA
HKD1_k127_4799155_14	1038866.KB902784_gene4665	2.766e-21	96.0	COG3360@1|root,COG3360@2|Bacteria,1PE74@1224|Proteobacteria,2UCH8@28211|Alphaproteobacteria,3K04J@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_4799155_4	472759.Nhal_2645	1.917e-85	288.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,1S23B@1236|Gammaproteobacteria,1WW1Q@135613|Chromatiales	135613|Chromatiales	S	Belongs to the WrbA family	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD1_k127_4799155_15	768066.HELO_2553	3.029e-21	96.0	COG1254@1|root,COG1254@2|Bacteria,1N6NU@1224|Proteobacteria,1SCPF@1236|Gammaproteobacteria,1XKYH@135619|Oceanospirillales	135619|Oceanospirillales	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD1_k127_4799155_8	1317118.ATO8_05191	5.05e-57	205.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria,4KMHQ@93682|Roseivivax	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1285)	MA20_44640	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
HKD1_k127_4799155_11	696369.KI912183_gene2778	4.323e-42	164.0	COG1451@1|root,COG1451@2|Bacteria,1V6WP@1239|Firmicutes,24JGH@186801|Clostridia,2626V@186807|Peptococcaceae	186801|Clostridia	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD1_k127_4799155_7	522306.CAP2UW1_1584	8.494e-71	244.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2WFSD@28216|Betaproteobacteria,1KQZF@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD1_k127_4799155_1	1049564.TevJSym_cb00050	5.696e-216	694.0	COG4232@1|root,COG4232@2|Bacteria,1MU8W@1224|Proteobacteria,1RPF7@1236|Gammaproteobacteria,1J6D9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CO	Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps	dsbD	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC,DsbD,Thioredoxin,Thioredoxin_7
HKD1_k127_4799155_12	396588.Tgr7_1603	4.469e-26	115.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,1RMX7@1236|Gammaproteobacteria,1WWE1@135613|Chromatiales	135613|Chromatiales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_4799155_18	314278.NB231_04145	8.388e-12	69.0	COG1487@1|root,COG1487@2|Bacteria,1QG6Z@1224|Proteobacteria,1SFI1@1236|Gammaproteobacteria,1X124@135613|Chromatiales	135613|Chromatiales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_4799155_16	858215.Thexy_1760	1.315e-15	82.0	COG1669@1|root,COG1669@2|Bacteria,1V8YJ@1239|Firmicutes,25DTZ@186801|Clostridia,42GH8@68295|Thermoanaerobacterales	186801|Clostridia	L	Nucleotidyltransferase domain	-	-	-	ko:K07076	-	-	-	-	ko00000	-	-	-	NTP_transf_2
HKD1_k127_4799155_20	324602.Caur_3708	2.409e-05	48.0	2AP8B@1|root,31EA7@2|Bacteria,2G9JM@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HKD1_k127_4799155_21	936573.HMPREF1147_0350	0.0008002	42.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	vapC	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
HKD1_k127_4803015_0	383372.Rcas_1872	4.68e-193	614.0	COG3459@1|root,COG3459@2|Bacteria	2|Bacteria	G	carbohydrate binding	-	-	2.4.1.20	ko:K00702	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000	-	GT36	-	DUF3131,Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD1_k127_4803015_1	1356852.N008_01765	4.575e-58	210.0	COG2357@1|root,COG2357@2|Bacteria,4NFMF@976|Bacteroidetes,47P2Z@768503|Cytophagia	976|Bacteroidetes	S	RelA SpoT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GTA_TIM
HKD1_k127_4820036_0	580332.Slit_1196	1.217e-281	887.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2VJ54@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD1_k127_4820036_1	105559.Nwat_2258	4.849e-29	121.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,1RN14@1236|Gammaproteobacteria,1WWPM@135613|Chromatiales	135613|Chromatiales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD1_k127_4864333_8	1344012.ATMI01000005_gene771	2.88e-84	284.0	COG0116@1|root,COG1092@1|root,COG0116@2|Bacteria,COG1092@2|Bacteria,1MUQM@1224|Proteobacteria,1RNMH@1236|Gammaproteobacteria,4BUN3@82986|Tatumella	1236|Gammaproteobacteria	J	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA	rlmL	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0008990,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016435,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0036265,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070043,GO:0070475,GO:0070476,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.173,2.1.1.264	ko:K12297	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,THUMP,UPF0020
HKD1_k127_4864333_6	1247649.D560_3607	1.376e-103	344.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VK1I@28216|Betaproteobacteria,3T2HH@506|Alcaligenaceae	28216|Betaproteobacteria	E	branched-chain amino acid transport	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_4864333_7	864073.HFRIS_016327	8.091e-101	342.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VHQC@28216|Betaproteobacteria,478CW@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4864333_1	395019.Bmul_3625	3.235e-167	535.0	COG4177@1|root,COG4177@2|Bacteria,1MV66@1224|Proteobacteria,2VH43@28216|Betaproteobacteria,1K3GD@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2,DUF3382
HKD1_k127_4864333_3	1049564.TevJSym_bf00220	4.119e-156	505.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,1RPVJ@1236|Gammaproteobacteria,1J707@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Metal dependent phosphohydrolases with conserved 'HD' motif.	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD1_k127_4864333_9	608538.HTH_1886	3.826e-19	90.0	COG0425@1|root,COG0425@2|Bacteria	2|Bacteria	O	sulfur carrier activity	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
HKD1_k127_4864333_2	743720.Psefu_3206	1.197e-157	507.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,1RP5V@1236|Gammaproteobacteria,1YWJY@136845|Pseudomonas putida group	1236|Gammaproteobacteria	E	PFAM Extracellular ligand-binding receptor	braC	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_4864333_4	349521.HCH_01254	1.802e-132	428.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria,1XH8D@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_4864333_0	686340.Metal_0733	3.394e-267	830.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,1RP81@1236|Gammaproteobacteria,1XDZD@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD1_k127_4864333_5	631362.Thi970DRAFT_02943	1.487e-120	390.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,1RMT8@1236|Gammaproteobacteria,1WXCW@135613|Chromatiales	135613|Chromatiales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD1_k127_4869673_2	768671.ThimaDRAFT_0780	3.559e-57	203.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,1RPHI@1236|Gammaproteobacteria,1WWGZ@135613|Chromatiales	135613|Chromatiales	J	PFAM tRNA synthetase class II (G H P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_4869673_3	396588.Tgr7_2047	1.867e-37	148.0	COG2976@1|root,COG2976@2|Bacteria,1N117@1224|Proteobacteria,1S95P@1236|Gammaproteobacteria,1WY25@135613|Chromatiales	135613|Chromatiales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HKD1_k127_4869673_1	1049564.TevJSym_ac01900	8.439e-106	356.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,1RN4V@1236|Gammaproteobacteria,1J5PH@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamB	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008104,GO:0008150,GO:0008152,GO:0009279,GO:0009987,GO:0016020,GO:0016043,GO:0016491,GO:0019867,GO:0022607,GO:0030312,GO:0030313,GO:0031224,GO:0031230,GO:0031241,GO:0031246,GO:0031975,GO:0032991,GO:0033036,GO:0034613,GO:0042802,GO:0043163,GO:0043165,GO:0044085,GO:0044091,GO:0044425,GO:0044462,GO:0044464,GO:0045184,GO:0045229,GO:0051179,GO:0051205,GO:0051234,GO:0051641,GO:0055114,GO:0061024,GO:0070727,GO:0071709,GO:0071840,GO:0071944,GO:0072657,GO:0090150,GO:0098552,GO:0098796,GO:1990063	-	ko:K17713	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	PQQ_2,PQQ_3
HKD1_k127_4869673_5	595494.Tola_0935	2.873e-16	83.0	COG1555@1|root,COG1555@2|Bacteria,1N6Q3@1224|Proteobacteria,1SC7U@1236|Gammaproteobacteria,1Y4V5@135624|Aeromonadales	135624|Aeromonadales	L	Helix-hairpin-helix motif	-	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3
HKD1_k127_4869673_6	78245.Xaut_4571	9.45e-09	62.0	COG0657@1|root,COG0657@2|Bacteria,1RD8A@1224|Proteobacteria,2U1B8@28211|Alphaproteobacteria,3EZVU@335928|Xanthobacteraceae	28211|Alphaproteobacteria	I	PFAM Alpha beta hydrolase fold-3 domain protein	-	-	3.1.1.83	ko:K14731	ko00903,ko00930,ko01220,map00903,map00930,map01220	-	R03751,R06390,R06391,R06392,R06393	RC00713,RC00983,RC01505	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_3
HKD1_k127_4869673_7	264198.Reut_A1793	2.746e-07	53.0	COG1878@1|root,COG1878@2|Bacteria,1MV8S@1224|Proteobacteria,2VNYM@28216|Betaproteobacteria,1KBVW@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD1_k127_4869673_0	861299.J421_4293	2.536e-174	562.0	COG0661@1|root,COG0661@2|Bacteria,1ZSYX@142182|Gemmatimonadetes	2|Bacteria	S	ABC1 family	ubiB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009987,GO:0016020,GO:0042180,GO:0042181,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901576,GO:1901661,GO:1901663	-	ko:K03688	-	-	-	-	ko00000	-	-	iYL1228.KPN_04331	ABC1
HKD1_k127_4869673_4	1078020.KEK_05482	8.308e-17	82.0	COG1073@1|root,COG1073@2|Bacteria,2I8SP@201174|Actinobacteria,234F7@1762|Mycobacteriaceae	201174|Actinobacteria	S	alpha beta	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4936994_0	1173264.KI913949_gene4045	2.314e-123	409.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_4936994_1	768671.ThimaDRAFT_4530	1.099e-85	291.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,1TKAD@1236|Gammaproteobacteria,1X15X@135613|Chromatiales	135613|Chromatiales	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4936994_2	1196323.ALKF01000201_gene3021	0.0003688	44.0	COG5498@1|root,COG5498@2|Bacteria,1U7U3@1239|Firmicutes,4IT1H@91061|Bacilli,26SHU@186822|Paenibacillaceae	91061|Bacilli	M	glycoside hydrolase family 81	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_81,fn3
HKD1_k127_4938835_0	1453503.AU05_13400	5.011e-197	632.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,1RNBK@1236|Gammaproteobacteria,1YDAK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_4938835_1	1366050.N234_20255	3.188e-104	345.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria,2VIMJ@28216|Betaproteobacteria,1KGQV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD1_k127_4938835_2	375286.mma_1576	4.737e-53	193.0	COG1876@1|root,COG1876@2|Bacteria,1N1CQ@1224|Proteobacteria,2VYKK@28216|Betaproteobacteria,476N4@75682|Oxalobacteraceae	28216|Betaproteobacteria	M	D-alanyl-D-alanine carboxypeptidase	-	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
HKD1_k127_4938835_3	1173027.Mic7113_3502	1.766e-08	57.0	COG3675@1|root,COG3675@2|Bacteria	2|Bacteria	I	Lipase (class 3)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2974,LTD,Lipase_3
HKD1_k127_4939276_8	713586.KB900536_gene3027	2.037e-53	190.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,1RNPZ@1236|Gammaproteobacteria,1WW15@135613|Chromatiales	135613|Chromatiales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD1_k127_4939276_1	472759.Nhal_2574	8.832e-128	416.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1WWNT@135613|Chromatiales	135613|Chromatiales	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_4939276_9	243233.MCA0197	5.464e-42	159.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,1SASF@1236|Gammaproteobacteria,1XFJZ@135618|Methylococcales	135618|Methylococcales	I	COG0575 CDP-diglyceride synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CarS-like
HKD1_k127_4939276_6	439235.Dalk_2455	8.939e-66	234.0	COG2267@1|root,COG2267@2|Bacteria,1Q6AF@1224|Proteobacteria,42SE8@68525|delta/epsilon subdivisions,2X5UM@28221|Deltaproteobacteria,2MKDJ@213118|Desulfobacterales	28221|Deltaproteobacteria	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_4939276_2	945713.IALB_2926	3.79e-117	381.0	COG0588@1|root,COG0588@2|Bacteria	2|Bacteria	G	phosphoglycerate mutase activity	gpmA	GO:0003674,GO:0003824,GO:0004619,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005996,GO:0006006,GO:0006082,GO:0006090,GO:0006091,GO:0006094,GO:0006096,GO:0006109,GO:0006139,GO:0006140,GO:0006163,GO:0006164,GO:0006165,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006754,GO:0006757,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009108,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009132,GO:0009135,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009166,GO:0009167,GO:0009168,GO:0009179,GO:0009185,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009894,GO:0009987,GO:0010675,GO:0016051,GO:0016052,GO:0016053,GO:0016310,GO:0016853,GO:0016866,GO:0016868,GO:0017144,GO:0018130,GO:0019219,GO:0019220,GO:0019222,GO:0019318,GO:0019319,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019439,GO:0019637,GO:0019693,GO:0019752,GO:0031323,GO:0031329,GO:0032787,GO:0034248,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042866,GO:0043436,GO:0043455,GO:0043456,GO:0043470,GO:0043471,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046031,GO:0046034,GO:0046364,GO:0046390,GO:0046394,GO:0046434,GO:0046483,GO:0046496,GO:0046538,GO:0046700,GO:0046939,GO:0050789,GO:0050794,GO:0051171,GO:0051174,GO:0051186,GO:0051188,GO:0051193,GO:0051196,GO:0055086,GO:0060255,GO:0062012,GO:0065007,GO:0071704,GO:0072330,GO:0072521,GO:0072522,GO:0072524,GO:0072525,GO:0080090,GO:0090407,GO:1901135,GO:1901137,GO:1901292,GO:1901293,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901566,GO:1901575,GO:1901576,GO:1902031	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD1_k127_4939276_0	105559.Nwat_0028	3.735e-173	554.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,1RMSR@1236|Gammaproteobacteria,1WVW7@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_4939276_5	1123392.AQWL01000001_gene1588	1.201e-67	235.0	COG0693@1|root,COG0693@2|Bacteria,1N7T2@1224|Proteobacteria,2VS5Q@28216|Betaproteobacteria,1KSPI@119069|Hydrogenophilales	119069|Hydrogenophilales	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD1_k127_4939276_7	118163.Ple7327_2736	2.961e-54	196.0	COG3709@1|root,COG3709@2|Bacteria	2|Bacteria	P	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)	phnN	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006015,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019200,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019634,GO:0019637,GO:0019674,GO:0019693,GO:0033863,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046391,GO:0046483,GO:0046496,GO:0046835,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.23	ko:K05774	ko00030,map00030	-	R06836	RC00002	ko00000,ko00001,ko01000	-	-	iAF1260.b4094,iB21_1397.B21_03926,iBWG_1329.BWG_3809,iECBD_1354.ECBD_3936,iECB_1328.ECB_03966,iECDH10B_1368.ECDH10B_4285,iECDH1ME8569_1439.ECDH1ME8569_3953,iECD_1391.ECD_03966,iEKO11_1354.EKO11_4224,iEcDH1_1363.EcDH1_3897,iEcolC_1368.EcolC_3932,iJO1366.b4094,iSSON_1240.SSON_4270,iUMNK88_1353.UMNK88_4960,iY75_1357.Y75_RS21315	AAA_18,Guanylate_kin
HKD1_k127_4939276_3	1123401.JHYQ01000012_gene2834	6.75e-106	349.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,1RN4H@1236|Gammaproteobacteria,4606Q@72273|Thiotrichales	72273|Thiotrichales	L	Exodeoxyribonuclease III xth	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD1_k127_4939276_4	519989.ECTPHS_03844	1.078e-70	247.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,1RPBN@1236|Gammaproteobacteria,1WXDF@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	-	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD1_k127_4939276_13	1121403.AUCV01000032_gene2888	2.332e-10	67.0	COG4446@1|root,COG4446@2|Bacteria,1N31A@1224|Proteobacteria,433JZ@68525|delta/epsilon subdivisions,2WXZQ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF1499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1499
HKD1_k127_4939276_12	1234364.AMSF01000021_gene1253	4.358e-13	72.0	COG2050@1|root,COG2050@2|Bacteria,1RHAN@1224|Proteobacteria,1S79C@1236|Gammaproteobacteria,1X6H4@135614|Xanthomonadales	135614|Xanthomonadales	Q	Domain of unknown function (DUF4442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4442
HKD1_k127_4939276_14	1283300.ATXB01000002_gene2734	0.0009065	44.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_4939276_11	136037.KDR09345	1.746e-13	84.0	COG3320@1|root,KOG1221@2759|Eukaryota,39UF3@33154|Opisthokonta,3BJTD@33208|Metazoa,3D44J@33213|Bilateria,41UVI@6656|Arthropoda,3SI3N@50557|Insecta	33208|Metazoa	I	Catalyzes the reduction of fatty acyl-CoA to fatty alcohols	-	-	1.2.1.84	ko:K13356	ko00073,ko04146,ko04212,map00073,map04146,map04212	-	R09470	RC00004	ko00000,ko00001,ko01000	-	-	-	NAD_binding_4,Sterile
HKD1_k127_4939276_10	258533.BN977_04749	1.086e-13	85.0	COG1028@1|root,COG3320@1|root,COG1028@2|Bacteria,COG3320@2|Bacteria,2I2PV@201174|Actinobacteria,2348I@1762|Mycobacteriaceae	201174|Actinobacteria	M	Dehydrogenase	acrA1	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4,adh_short
HKD1_k127_5082489_4	1082931.KKY_1259	2.381e-34	138.0	COG1082@1|root,COG1082@2|Bacteria,1P5WP@1224|Proteobacteria,2U29B@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Xylose isomerase domain protein TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_5082489_1	512565.AMIS_66770	4.504e-77	271.0	COG2304@1|root,COG2304@2|Bacteria,2GNKP@201174|Actinobacteria,4D9FN@85008|Micromonosporales	201174|Actinobacteria	S	protein containing a von Willebrand factor type A (vWA) domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HKD1_k127_5082489_2	987059.RBXJA2T_01620	2.276e-72	256.0	COG2304@1|root,COG2304@2|Bacteria,1MXQ7@1224|Proteobacteria,2VHRY@28216|Betaproteobacteria,1KKCR@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	BatA,VWA,VWA_2
HKD1_k127_5082489_0	296591.Bpro_3892	2.745e-109	362.0	COG1721@1|root,COG1721@2|Bacteria,1Q7RR@1224|Proteobacteria,2VJHU@28216|Betaproteobacteria,4A9S6@80864|Comamonadaceae	28216|Betaproteobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_5082489_3	1380370.JIBA01000010_gene2364	3.132e-44	164.0	COG0714@1|root,COG0714@2|Bacteria,2GK07@201174|Actinobacteria,4FFZ1@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_5093448_0	1294143.H681_19200	4.872e-161	510.0	COG0834@1|root,COG0834@2|Bacteria,1MV5D@1224|Proteobacteria,1RNJJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	ET	Belongs to the bacterial solute-binding protein 3 family	aapJ	-	-	ko:K09969	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	SBP_bac_3
HKD1_k127_5093448_2	305700.B447_06542	7.074e-153	492.0	COG4597@1|root,COG4597@2|Bacteria,1MV0S@1224|Proteobacteria,2VIDZ@28216|Betaproteobacteria,2KWD4@206389|Rhodocyclales	206389|Rhodocyclales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K09970	ko02010,map02010	M00232	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
HKD1_k127_5093448_1	399739.Pmen_3558	5.047e-156	500.0	COG0765@1|root,COG0765@2|Bacteria,1MV3I@1224|Proteobacteria,1RPJR@1236|Gammaproteobacteria,1YD04@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	yhdY	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K02029,ko:K09971,ko:K10002,ko:K10037	ko02010,ko02020,map02010,map02020	M00227,M00230,M00232,M00236	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.18,3.A.1.3.19,3.A.1.3.2,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8	-	-	BPD_transp_1
HKD1_k127_5093448_3	1207075.PputUW4_04455	1.247e-72	246.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	(ABC) transporter	yhdZ	GO:0000166,GO:0003674,GO:0005488,GO:0005524,GO:0008144,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0097159,GO:0097367,GO:1901265,GO:1901363	3.6.3.21	ko:K02028,ko:K02029,ko:K09972,ko:K10004,ko:K10010	ko02010,ko02020,map02010,map02020	M00230,M00232,M00234,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.10,3.A.1.3.14,3.A.1.3.17,3.A.1.3.18,3.A.1.3.19,3.A.1.3.4,3.A.1.3.7,3.A.1.3.8	-	iJN746.PP_1300	ABC_tran
HKD1_k127_5108862_2	314278.NB231_00650	7.609e-35	136.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,1S9NV@1236|Gammaproteobacteria,1WYM1@135613|Chromatiales	135613|Chromatiales	U	TIGRFAM preprotein translocase, YajC subunit	-	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD1_k127_5108862_1	1266908.AQPB01000059_gene2601	4.572e-180	571.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,1RMY3@1236|Gammaproteobacteria,1WWQ8@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_5108862_0	713587.THITH_13490	0.0	1016.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,1RMCI@1236|Gammaproteobacteria,1WXIB@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_5112472_4	383372.Rcas_0702	2.487e-109	357.0	COG0183@1|root,COG0183@2|Bacteria,2GAQ4@200795|Chloroflexi,3770V@32061|Chloroflexia	32061|Chloroflexia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_5112472_6	314278.NB231_07912	2.989e-57	206.0	COG2310@1|root,COG2310@2|Bacteria,1R8MN@1224|Proteobacteria,1S0KB@1236|Gammaproteobacteria,1WW86@135613|Chromatiales	135613|Chromatiales	T	stress protein	-	-	-	ko:K05791	-	-	-	-	ko00000	-	-	-	TerD
HKD1_k127_5112472_10	1042209.HK44_027375	3.845e-09	63.0	2DR2Y@1|root,339YA@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4124)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4124
HKD1_k127_5112472_2	395493.BegalDRAFT_2551	1.621e-289	898.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,1RMQQ@1236|Gammaproteobacteria,45ZVD@72273|Thiotrichales	72273|Thiotrichales	E	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_5112472_5	765912.Thimo_0383	3.618e-69	238.0	COG0440@1|root,COG0440@2|Bacteria,1RAGN@1224|Proteobacteria,1S20I@1236|Gammaproteobacteria,1WXGS@135613|Chromatiales	135613|Chromatiales	E	TIGRFAM Acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HKD1_k127_5112472_3	243233.MCA2272	5.451e-178	561.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,1RNA8@1236|Gammaproteobacteria,1XE7R@135618|Methylococcales	135618|Methylococcales	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD1_k127_5112472_9	518766.Rmar_0887	1.001e-16	82.0	COG5428@1|root,COG5428@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2283)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2283
HKD1_k127_5112472_1	396588.Tgr7_0817	0.0	1391.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,1RN55@1236|Gammaproteobacteria,1WWC8@135613|Chromatiales	135613|Chromatiales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_5112472_0	78245.Xaut_0680	0.0	1468.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2TUMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG0553 Superfamily II DNA RNA helicases, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3883,Helicase_C,SNF2_N
HKD1_k127_5132192_0	472759.Nhal_0500	1.505e-293	912.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,1RM9M@1236|Gammaproteobacteria,1WWZC@135613|Chromatiales	135613|Chromatiales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_5132192_3	472759.Nhal_0502	3.327e-148	479.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,1RNVF@1236|Gammaproteobacteria,1WWSU@135613|Chromatiales	135613|Chromatiales	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD1_k127_5132192_5	472759.Nhal_3853	3.217e-105	350.0	COG0352@1|root,COG0494@1|root,COG0352@2|Bacteria,COG0494@2|Bacteria,1RCZM@1224|Proteobacteria,1RS3S@1236|Gammaproteobacteria,1WW2I@135613|Chromatiales	135613|Chromatiales	HL	Thiamine monophosphate synthase	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX,NUDIX_4,TMP-TENI
HKD1_k127_5132192_10	1123368.AUIS01000003_gene1574	2.169e-09	64.0	2EQTE@1|root,33ID4@2|Bacteria,1NJQ1@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5132192_6	243159.AFE_2656	4.28e-81	276.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,1RSAG@1236|Gammaproteobacteria,2NDNP@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_5132192_9	857087.Metme_0679	2.615e-16	82.0	COG4118@1|root,COG4118@2|Bacteria,1P66E@1224|Proteobacteria	1224|Proteobacteria	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_5132192_1	395493.BegalDRAFT_0684	6.077e-282	883.0	COG2943@1|root,COG2943@2|Bacteria,1MVXZ@1224|Proteobacteria,1RMGX@1236|Gammaproteobacteria,461R2@72273|Thiotrichales	72273|Thiotrichales	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_2_3,Glycos_transf_2
HKD1_k127_5132192_11	768671.ThimaDRAFT_0682	6.674e-06	55.0	2CJKN@1|root,333KF@2|Bacteria,1NG0T@1224|Proteobacteria,1SFAA@1236|Gammaproteobacteria,1WZJH@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5132192_2	246197.MXAN_2385	6.878e-153	499.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,42QKA@68525|delta/epsilon subdivisions,2WK1I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoG	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
HKD1_k127_5132192_8	1173024.KI912148_gene3092	4.535e-62	220.0	COG4099@1|root,COG4099@2|Bacteria,1G426@1117|Cyanobacteria	1117|Cyanobacteria	S	Esterase PHB depolymerase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Peptidase_S9
HKD1_k127_5132192_4	472759.Nhal_1067	5.434e-139	449.0	COG1234@1|root,COG1234@2|Bacteria,1PPRD@1224|Proteobacteria,1RRV8@1236|Gammaproteobacteria,1X01R@135613|Chromatiales	135613|Chromatiales	S	Beta-lactamase superfamily domain	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
HKD1_k127_5132192_7	1157708.KB907450_gene6347	2.09e-71	243.0	COG0346@1|root,COG0346@2|Bacteria,1RA9H@1224|Proteobacteria,2VQ0D@28216|Betaproteobacteria,4ADFN@80864|Comamonadaceae	28216|Betaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_5132527_4	713586.KB900536_gene2769	2.695e-109	359.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,1RMBU@1236|Gammaproteobacteria,1WVXU@135613|Chromatiales	135613|Chromatiales	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_5132527_8	1238182.C882_3089	1.857e-57	207.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2JRGA@204441|Rhodospirillales	204441|Rhodospirillales	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_5132527_10	419947.MRA_1849	1.119e-26	114.0	COG1848@1|root,COG1848@2|Bacteria	2|Bacteria	G	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	GO:0005575,GO:0005576	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_5132527_12	419947.MRA_1850	3.529e-05	49.0	2BE1Z@1|root,327SM@2|Bacteria,2HDGJ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5132527_1	395493.BegalDRAFT_0453	1.63e-322	1005.0	COG2183@1|root,COG2183@2|Bacteria,1MUA7@1224|Proteobacteria,1RMNH@1236|Gammaproteobacteria,45ZXY@72273|Thiotrichales	72273|Thiotrichales	K	Tex-like protein N-terminal domain	-	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD1_k127_5132527_11	243233.MCA2737	2.493e-21	99.0	2E600@1|root,330PC@2|Bacteria,1N9V9@1224|Proteobacteria,1SHAU@1236|Gammaproteobacteria,1XFBV@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5132527_6	1283300.ATXB01000002_gene2564	3.956e-71	248.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,1S5RT@1236|Gammaproteobacteria,1XFNH@135618|Methylococcales	135618|Methylococcales	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
HKD1_k127_5132527_0	1163617.SCD_n01479	0.0	1146.0	COG0466@1|root,COG0466@2|Bacteria,1NTR5@1224|Proteobacteria,2W1SU@28216|Betaproteobacteria	28216|Betaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_5132527_9	349124.Hhal_1785	1.621e-43	169.0	COG1357@1|root,COG1357@2|Bacteria,1N7U9@1224|Proteobacteria,1RYAA@1236|Gammaproteobacteria,1WXSC@135613|Chromatiales	135613|Chromatiales	S	PFAM Pentapeptide	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD1_k127_5132527_5	105559.Nwat_2728	3.009e-77	267.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,1RQYC@1236|Gammaproteobacteria,1WXP3@135613|Chromatiales	135613|Chromatiales	I	PFAM Phospholipid glycerol acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_5132527_7	472759.Nhal_0220	1.653e-66	231.0	COG0241@1|root,COG0241@2|Bacteria,1RDGR@1224|Proteobacteria,1S3UD@1236|Gammaproteobacteria,1WY8W@135613|Chromatiales	135613|Chromatiales	E	D,D-heptose 1,7-bisphosphate phosphatase	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_like
HKD1_k127_5132527_2	396588.Tgr7_3255	5.897e-270	847.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,1RNR3@1236|Gammaproteobacteria,1WWSJ@135613|Chromatiales	135613|Chromatiales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD1_k127_5132527_3	472759.Nhal_0218	4.292e-172	543.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,1RMYI@1236|Gammaproteobacteria,1WWUE@135613|Chromatiales	135613|Chromatiales	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HKD1_k127_5143601_1	225937.HP15_464	1.128e-120	399.0	COG1752@1|root,COG1752@2|Bacteria,1R7RX@1224|Proteobacteria,1RRTH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD1_k127_5143601_0	118163.Ple7327_1013	2.51e-157	505.0	COG0192@1|root,COG0192@2|Bacteria,1G0RZ@1117|Cyanobacteria,3VNM3@52604|Pleurocapsales	1117|Cyanobacteria	H	Belongs to the AdoMet synthase family	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_5143601_2	1123368.AUIS01000003_gene1785	1.514e-101	337.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,2NCC6@225057|Acidithiobacillales	1236|Gammaproteobacteria	P	Cation transport ATPase (P-type)	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_5176869_7	1027273.GZ77_09370	3.093e-31	126.0	COG5433@1|root,COG5433@2|Bacteria,1MXB5@1224|Proteobacteria,1RSAV@1236|Gammaproteobacteria,1XKX4@135619|Oceanospirillales	135619|Oceanospirillales	L	DDE_Tnp_1-associated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_5176869_4	76114.ebA563	6.255e-78	262.0	COG1943@1|root,COG1943@2|Bacteria,1MX19@1224|Proteobacteria,2VTIQ@28216|Betaproteobacteria,2KYTR@206389|Rhodocyclales	206389|Rhodocyclales	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_5176869_6	398578.Daci_4398	3.626e-35	138.0	COG3861@1|root,COG3861@2|Bacteria,1N0R6@1224|Proteobacteria,2VUVS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM PRC-barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_5176869_3	485913.Krac_0288	1.306e-87	293.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_5176869_1	1125863.JAFN01000001_gene3126	2.86e-142	464.0	COG5659@1|root,COG5659@2|Bacteria,1MWAV@1224|Proteobacteria,43BD6@68525|delta/epsilon subdivisions,2X6S2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_5176869_9	195250.CM001776_gene2812	1.652e-08	56.0	COG3039@1|root,COG3039@2|Bacteria,1GJS6@1117|Cyanobacteria,1H2PI@1129|Synechococcus	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD1_k127_5176869_8	63737.Npun_F0119	1.289e-09	71.0	2DXD6@1|root,344HN@2|Bacteria,1GFM2@1117|Cyanobacteria,1HT45@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5176869_2	489825.LYNGBM3L_00410	9.637e-109	375.0	COG3316@1|root,COG3316@2|Bacteria,1GR5S@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5176869_5	28072.Nos7524_4118	2.194e-58	216.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G5BJ@1117|Cyanobacteria,1HP71@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase	-	-	-	ko:K07494	-	-	-	-	ko00000	-	-	-	DDE_3,HTH_Tnp_IS630
HKD1_k127_5185165_1	396588.Tgr7_0191	5.241e-255	798.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1WWWP@135613|Chromatiales	135613|Chromatiales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topo_Zn_Ribbon,Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
HKD1_k127_5185165_12	572477.Alvin_2067	1.101e-60	216.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1S610@1236|Gammaproteobacteria,1WY2S@135613|Chromatiales	135613|Chromatiales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Catalyzes the conversion of L-threonine, HCO(3)(-) CO(2) and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate	tsaC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD1_k127_5185165_3	323261.Noc_2824	1.001e-153	490.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,1RMM8@1236|Gammaproteobacteria,1WX13@135613|Chromatiales	135613|Chromatiales	H	Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen-IX	hemF	GO:0003674,GO:0005488,GO:0005515,GO:0042802,GO:0042803,GO:0046983	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HKD1_k127_5185165_11	292415.Tbd_0747	1.241e-65	229.0	COG1051@1|root,COG1051@2|Bacteria,1REBW@1224|Proteobacteria,2VQ39@28216|Betaproteobacteria,1KSGX@119069|Hydrogenophilales	119069|Hydrogenophilales	F	Nudix N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX,Nudix_N_2
HKD1_k127_5185165_5	629265.PMA4326_28232	3.848e-134	436.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,1SKPD@1236|Gammaproteobacteria,1Z6DK@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	P	the ABC transporter	dppF	-	-	ko:K12372,ko:K19230	ko01503,ko02010,map01503,map02010	M00324,M00739	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_5185165_4	82995.CR62_10490	2.188e-141	456.0	COG0444@1|root,COG0444@2|Bacteria,1R4KB@1224|Proteobacteria,1SMBI@1236|Gammaproteobacteria,4002P@613|Serratia	1236|Gammaproteobacteria	EP	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF	dppD	GO:0000166,GO:0003674,GO:0005215,GO:0005488,GO:0005524,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0008144,GO:0008150,GO:0015232,GO:0015886,GO:0016020,GO:0017076,GO:0022857,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044464,GO:0051179,GO:0051181,GO:0051184,GO:0051234,GO:0055085,GO:0071702,GO:0071705,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901678	-	ko:K12371,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00324,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	iYL1228.KPN_03896	ABC_tran,oligo_HPY
HKD1_k127_5185165_6	1238182.C882_2839	1.662e-128	417.0	COG1173@1|root,COG1173@2|Bacteria,1MUG0@1224|Proteobacteria,2VETJ@28211|Alphaproteobacteria,2JQSG@204441|Rhodospirillales	204441|Rhodospirillales	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K12370	ko02010,map02010	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_5185165_2	1201293.AKXQ01000007_gene559	1.07e-156	500.0	COG0601@1|root,COG0601@2|Bacteria,1MU8Z@1224|Proteobacteria,1RNJ1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type dipeptide oligopeptide nickel transport systems, permease components	dppB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K12369,ko:K19227	ko01503,ko02010,map01503,map02010	M00324,M00739	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.5	-	iECUMN_1333.ECUMN_4053	BPD_transp_1
HKD1_k127_5185165_0	1110502.TMO_3019	2.519e-265	826.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TR1D@28211|Alphaproteobacteria,2JQSW@204441|Rhodospirillales	204441|Rhodospirillales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K12368	ko02010,ko02030,map02010,map02030	M00324	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_5185165_9	1316936.K678_13201	3.107e-90	305.0	COG3931@1|root,COG3931@2|Bacteria,1QI71@1224|Proteobacteria,2TVK6@28211|Alphaproteobacteria,2JRQF@204441|Rhodospirillales	204441|Rhodospirillales	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HKD1_k127_5185165_8	1288494.EBAPG3_27270	3.529e-100	335.0	COG1216@1|root,COG1216@2|Bacteria,1NM61@1224|Proteobacteria,2VKSQ@28216|Betaproteobacteria,371VJ@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Glycosyltransferase like family	-	-	-	ko:K07011	-	-	-	-	ko00000	-	-	-	Glyco_trans_2_3,Glycos_transf_2
HKD1_k127_5185165_10	697282.Mettu_1774	4.27e-83	287.0	COG0451@1|root,COG0451@2|Bacteria,1R9RA@1224|Proteobacteria,1T543@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	Epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_5185165_7	765912.Thimo_0535	1.894e-118	394.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,1MWKE@1224|Proteobacteria,1RZWQ@1236|Gammaproteobacteria,1WW2K@135613|Chromatiales	135613|Chromatiales	M	PFAM Transglycosylase SLT domain	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD1_k127_5185165_15	519989.ECTPHS_04294	4.53e-27	117.0	COG3149@1|root,COG3149@2|Bacteria,1N8VZ@1224|Proteobacteria,1SCSU@1236|Gammaproteobacteria,1WZQA@135613|Chromatiales	135613|Chromatiales	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	ko:K02462	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSM
HKD1_k127_5185165_13	396588.Tgr7_0236	4.461e-47	184.0	COG3297@1|root,COG3297@2|Bacteria,1NVVW@1224|Proteobacteria,1S01F@1236|Gammaproteobacteria,1X1FM@135613|Chromatiales	135613|Chromatiales	U	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins	-	-	-	ko:K02461	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	GspL_C,T2SSL
HKD1_k127_5185165_14	395493.BegalDRAFT_3088	1.891e-45	180.0	COG3156@1|root,COG3156@2|Bacteria,1RAQM@1224|Proteobacteria,1S2N8@1236|Gammaproteobacteria,460PF@72273|Thiotrichales	72273|Thiotrichales	U	Type II secretion system (T2SS), protein K	-	-	-	ko:K02460	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSK
HKD1_k127_5236958_0	395493.BegalDRAFT_3527	2.892e-213	672.0	COG1249@1|root,COG1249@2|Bacteria,1MVVE@1224|Proteobacteria,1RMJT@1236|Gammaproteobacteria,460BQ@72273|Thiotrichales	72273|Thiotrichales	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain	-	-	1.6.1.1	ko:K00322	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_5236958_2	2340.JV46_13470	1.142e-72	258.0	COG0472@1|root,COG0472@2|Bacteria,1MWYW@1224|Proteobacteria,1RNAP@1236|Gammaproteobacteria,1J6BS@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	M	Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP- C55)	wecA	GO:0000271,GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0005975,GO:0005976,GO:0006629,GO:0008144,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008963,GO:0009058,GO:0009059,GO:0009103,GO:0009246,GO:0009274,GO:0009276,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0016051,GO:0016740,GO:0016772,GO:0016780,GO:0030145,GO:0030312,GO:0030313,GO:0031224,GO:0031226,GO:0031975,GO:0033692,GO:0034637,GO:0034645,GO:0042546,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044425,GO:0044459,GO:0044464,GO:0045229,GO:0046378,GO:0046872,GO:0046914,GO:0070589,GO:0071554,GO:0071555,GO:0071704,GO:0071840,GO:0071944,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	iECSF_1327.ECSF_3624	Glycos_transf_4
HKD1_k127_5236958_4	292564.Cyagr_1980	8.89e-10	63.0	COG1487@1|root,COG1487@2|Bacteria	2|Bacteria	S	nuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_5236958_1	1121013.P873_02595	4.644e-81	274.0	COG0438@1|root,COG0438@2|Bacteria,1MY5T@1224|Proteobacteria,1RS9J@1236|Gammaproteobacteria,1X8JH@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyl transferase 4-like domain	-	-	-	ko:K03208	-	-	-	-	ko00000	-	GT4	-	Glyco_trans_4_4,Glycos_transf_1
HKD1_k127_5236958_5	32057.KB217478_gene5388	3.371e-08	58.0	COG4636@1|root,COG4636@2|Bacteria,1G4MT@1117|Cyanobacteria,1HMD8@1161|Nostocales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_5236958_3	1449357.JQLK01000001_gene578	3.141e-19	91.0	COG4636@1|root,COG4636@2|Bacteria,1WIPB@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_5237625_3	686340.Metal_1857	5.712e-106	347.0	COG0559@1|root,COG0559@2|Bacteria,1MU25@1224|Proteobacteria,1RNDV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_5237625_1	686340.Metal_1856	8.28e-146	471.0	COG0683@1|root,COG0683@2|Bacteria,1MWJ1@1224|Proteobacteria,1RP5V@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	With LivFGHM is involved in the high affinity leucine transport	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_5237625_4	1215114.BBIU01000022_gene2902	4.105e-62	228.0	COG0438@1|root,COG0438@2|Bacteria,1QIXJ@1224|Proteobacteria,1RZ2C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_5237625_0	686340.Metal_3042	1.6e-182	585.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,1RQ1A@1236|Gammaproteobacteria,1XE8C@135618|Methylococcales	135618|Methylococcales	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HKD1_k127_5237625_5	243233.MCA3073	5.151e-58	217.0	2DUD0@1|root,33Q23@2|Bacteria,1PW9M@1224|Proteobacteria,1THYI@1236|Gammaproteobacteria,1XG1X@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5237625_9	378806.STAUR_3926	5.989e-28	120.0	COG3039@1|root,COG3039@2|Bacteria,1Q3I2@1224|Proteobacteria,42XM0@68525|delta/epsilon subdivisions,2WSIG@28221|Deltaproteobacteria,2YZ3N@29|Myxococcales	28221|Deltaproteobacteria	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_5237625_13	314345.SPV1_03293	1.328e-10	64.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria	1224|Proteobacteria	P	ATPase, P-type transporting, HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_5237625_10	555778.Hneap_1402	4.493e-24	104.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1WX32@135613|Chromatiales	135613|Chromatiales	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_5237625_7	765913.ThidrDRAFT_0467	1.381e-48	191.0	2C1UW@1|root,32XSR@2|Bacteria,1N37G@1224|Proteobacteria,1SQ6C@1236|Gammaproteobacteria,1X150@135613|Chromatiales	135613|Chromatiales	S	YfdX protein	-	-	-	-	-	-	-	-	-	-	-	-	YfdX
HKD1_k127_5237625_2	335543.Sfum_3051	1.587e-144	464.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,42P0J@68525|delta/epsilon subdivisions,2WJJQ@28221|Deltaproteobacteria,2MSJK@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	PFAM cytochrome bd ubiquinol oxidase, subunit I	-	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD1_k127_5237625_12	1122929.KB908215_gene617	4.108e-14	79.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	oxidase subunit	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD1_k127_5237625_14	197221.22295326	3.578e-06	49.0	COG1294@1|root,COG1294@2|Bacteria,1G0PM@1117|Cyanobacteria	1117|Cyanobacteria	C	TIGRFAM cytochrome d oxidase, subunit II (cydB)	cydB	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	iAPECO1_1312.cydB,iJN678.cydB	Cyt_bd_oxida_II
HKD1_k127_5237625_11	102125.Xen7305DRAFT_00028960	5.611e-18	88.0	COG3385@1|root,COG3385@2|Bacteria,1G2NV@1117|Cyanobacteria,3VMET@52604|Pleurocapsales	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1,DDE_Tnp_2
HKD1_k127_5237625_8	272134.KB731325_gene631	2.975e-32	131.0	COG3385@1|root,COG3385@2|Bacteria,1G2NV@1117|Cyanobacteria,1HEUG@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1,DDE_Tnp_2
HKD1_k127_5237625_6	765913.ThidrDRAFT_0471	6.095e-57	211.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,1RQZQ@1236|Gammaproteobacteria,1WXQ3@135613|Chromatiales	135613|Chromatiales	P	FimV N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Voltage_CLC
HKD1_k127_5245404_5	478741.JAFS01000002_gene50	3.835e-19	89.0	COG0479@1|root,COG0479@2|Bacteria	2|Bacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	asrA	-	-	ko:K16950	ko00920,ko01120,map00920,map01120	-	R00858,R10146	RC00065	ko00000,ko00001	-	-	-	Fer4_22
HKD1_k127_5245404_0	857087.Metme_3222	1.442e-85	290.0	COG3547@1|root,COG3547@2|Bacteria,1MXKJ@1224|Proteobacteria,1RSCP@1236|Gammaproteobacteria,1XFTF@135618|Methylococcales	135618|Methylococcales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_5245404_3	500153.JOEK01000003_gene939	1.72e-32	131.0	COG0855@1|root,COG0855@2|Bacteria,2GJ0B@201174|Actinobacteria	201174|Actinobacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_5245404_1	1125863.JAFN01000001_gene636	1.795e-54	200.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,42RIE@68525|delta/epsilon subdivisions,2WNU1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	N	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_5245404_6	1232437.KL661986_gene3647	8.185e-12	66.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5245404_2	1232437.KL661986_gene3647	1.164e-44	165.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5245404_4	1121403.AUCV01000064_gene4129	1.664e-22	104.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,42N7M@68525|delta/epsilon subdivisions,2WIJ0@28221|Deltaproteobacteria,2MITQ@213118|Desulfobacterales	28221|Deltaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5281083_12	472759.Nhal_0786	9.344e-07	50.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5,DDE_Tnp_1
HKD1_k127_5281083_11	1049564.TevJSym_at00570	8.417e-07	56.0	2CM34@1|root,32WDG@2|Bacteria,1N4BM@1224|Proteobacteria,1SAXK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2939)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2939
HKD1_k127_5281083_10	395493.BegalDRAFT_0594	2.141e-08	57.0	2CM34@1|root,30JH7@2|Bacteria,1RFX8@1224|Proteobacteria,1S3XR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2939)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2939
HKD1_k127_5281083_4	1173024.KI912149_gene6418	3.1e-37	143.0	COG4115@1|root,COG4115@2|Bacteria,1G8CY@1117|Cyanobacteria,1JMF0@1189|Stigonemataceae	1117|Cyanobacteria	S	YoeB-like toxin of bacterial type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	YoeB_toxin
HKD1_k127_5281083_5	1158762.KB898040_gene1541	3.62e-35	135.0	COG2161@1|root,COG2161@2|Bacteria,1N07B@1224|Proteobacteria,1S90V@1236|Gammaproteobacteria,1WZFH@135613|Chromatiales	135613|Chromatiales	D	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_5281083_8	1249627.D779_0358	1.732e-24	105.0	COG3676@1|root,COG3677@1|root,COG3676@2|Bacteria,COG3677@2|Bacteria,1R7ZF@1224|Proteobacteria,1S6YQ@1236|Gammaproteobacteria,1WYGX@135613|Chromatiales	135613|Chromatiales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
HKD1_k127_5281083_9	981223.AIED01000020_gene774	7.942e-09	59.0	COG1826@1|root,COG1826@2|Bacteria,1N6S4@1224|Proteobacteria,1SCC7@1236|Gammaproteobacteria,3NPBJ@468|Moraxellaceae	1236|Gammaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0002790,GO:0003674,GO:0005215,GO:0006810,GO:0008104,GO:0008150,GO:0008565,GO:0009306,GO:0009987,GO:0015031,GO:0015833,GO:0032940,GO:0033036,GO:0042886,GO:0045184,GO:0046903,GO:0051179,GO:0051234,GO:0071702,GO:0071705	-	ko:K03116,ko:K03425	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_5281083_7	472759.Nhal_1380	5.588e-27	113.0	COG0071@1|root,COG0071@2|Bacteria,1NPJI@1224|Proteobacteria,1SRY5@1236|Gammaproteobacteria,1X21C@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_5281083_1	472759.Nhal_1379	0.0	1065.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_5281083_2	1175306.GWL_09750	3.823e-173	557.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VISZ@28216|Betaproteobacteria,4736U@75682|Oxalobacteraceae	28216|Betaproteobacteria	MU	Outer membrane efflux protein	nodT	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_5281083_0	1005048.CFU_1183	0.0	1393.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,47357@75682|Oxalobacteraceae	28216|Betaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	mdtC	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_5281083_3	489825.LYNGBM3L_70800	2.01e-104	353.0	COG0732@1|root,COG0732@2|Bacteria,1G1K5@1117|Cyanobacteria,1HAGE@1150|Oscillatoriales	1117|Cyanobacteria	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_5287262_2	1026882.MAMP_02926	1.009e-39	154.0	COG2888@1|root,COG2888@2|Bacteria,1P9T7@1224|Proteobacteria,1RYIB@1236|Gammaproteobacteria,460Y8@72273|Thiotrichales	72273|Thiotrichales	J	Zinc-ribbon containing domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1451
HKD1_k127_5287262_0	1415778.JQMM01000001_gene29	5.449e-137	444.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,1RMKW@1236|Gammaproteobacteria,1J4SK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	GO:0002097,GO:0002099,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009314,GO:0009451,GO:0009628,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016853,GO:0018130,GO:0019438,GO:0034404,GO:0034470,GO:0034641,GO:0034654,GO:0034660,GO:0042455,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0050896,GO:0051075,GO:0055086,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD1_k127_5287262_1	1123368.AUIS01000003_gene1816	3.003e-131	427.0	COG0501@1|root,COG0501@2|Bacteria,1MUV4@1224|Proteobacteria,1RMN0@1236|Gammaproteobacteria,2NBV2@225057|Acidithiobacillales	1236|Gammaproteobacteria	O	Peptidase family M48	htpX	GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044425,GO:0044464,GO:0046872,GO:0046914,GO:0050896,GO:0070011,GO:0071704,GO:0071944,GO:0140096,GO:1901564	-	ko:K03799	-	M00743	-	-	ko00000,ko00002,ko01000,ko01002	-	-	-	Peptidase_M48
HKD1_k127_5288265_6	765912.Thimo_2552	3.344e-19	89.0	COG0810@1|root,COG0810@2|Bacteria,1R330@1224|Proteobacteria,1RQAX@1236|Gammaproteobacteria,1WWP5@135613|Chromatiales	135613|Chromatiales	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_5288265_2	314278.NB231_13306	7.694e-69	239.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,1S3YV@1236|Gammaproteobacteria,1WX8T@135613|Chromatiales	135613|Chromatiales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD1_k127_5288265_4	1123399.AQVE01000001_gene491	2.621e-34	137.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,1S96Q@1236|Gammaproteobacteria,4616K@72273|Thiotrichales	72273|Thiotrichales	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD1_k127_5288265_3	323261.Noc_0363	2.645e-43	166.0	COG0543@1|root,COG0543@2|Bacteria,1RF43@1224|Proteobacteria,1RQ7W@1236|Gammaproteobacteria,1X286@135613|Chromatiales	135613|Chromatiales	C	Oxidoreductase FAD-binding domain	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind
HKD1_k127_5288265_0	1211114.ALIP01000145_gene2746	9.586e-181	575.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,1RN8G@1236|Gammaproteobacteria,1X3Y4@135614|Xanthomonadales	135614|Xanthomonadales	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_5288265_1	1215092.PA6_003_00420	8.953e-81	274.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,1RNPM@1236|Gammaproteobacteria,1YDBW@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD1_k127_5288265_5	396588.Tgr7_2920	4.279e-23	103.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD1_k127_5322023_10	1255043.TVNIR_2245	8.186e-39	150.0	COG2227@1|root,COG2227@2|Bacteria,1RE7I@1224|Proteobacteria,1S6PD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	PFAM Tellurite resistance protein TehB	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23,Methyltransf_25,TehB
HKD1_k127_5322023_1	1049564.TevJSym_ag01000	7.398e-184	585.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RRXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Response regulator receiver	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activ_2,Sigma54_activat
HKD1_k127_5322023_0	396588.Tgr7_0199	7.492e-212	683.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,1RQ8B@1236|Gammaproteobacteria,1WXE6@135613|Chromatiales	135613|Chromatiales	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
HKD1_k127_5322023_9	314278.NB231_11619	8.88e-40	156.0	29CX4@1|root,2ZZV8@2|Bacteria,1RFY7@1224|Proteobacteria,1SBT1@1236|Gammaproteobacteria,1WYAZ@135613|Chromatiales	135613|Chromatiales	S	Domain of unknown function (DUF4390)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4390
HKD1_k127_5322023_2	379731.PST_0019	7.557e-136	445.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,1RN8X@1236|Gammaproteobacteria,1Z0WQ@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008169,GO:0008173,GO:0008649,GO:0008757,GO:0009383,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD1_k127_5322023_4	1049564.TevJSym_ag01040	1.379e-106	353.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,1RP1T@1236|Gammaproteobacteria,1J4V0@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	GO:0003674,GO:0003824,GO:0004479,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006413,GO:0006418,GO:0006431,GO:0006464,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016741,GO:0016742,GO:0019538,GO:0019752,GO:0019988,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036211,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071951,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	iECABU_c1320.ECABU_c37050,iECUMN_1333.ECUMN_3761,ic_1306.c4048	Formyl_trans_C,Formyl_trans_N
HKD1_k127_5322023_6	396588.Tgr7_0195	1.283e-78	265.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,1S247@1236|Gammaproteobacteria,1WXF4@135613|Chromatiales	135613|Chromatiales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD1_k127_5322023_7	396588.Tgr7_0194	4.504e-55	208.0	COG1652@1|root,COG1652@2|Bacteria,1MUBV@1224|Proteobacteria,1RPMB@1236|Gammaproteobacteria,1WWDN@135613|Chromatiales	135613|Chromatiales	S	PFAM Peptidoglycan-binding lysin domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_5322023_3	472759.Nhal_3814	2.402e-135	440.0	COG0758@1|root,COG0758@2|Bacteria,1MVF6@1224|Proteobacteria,1RPJE@1236|Gammaproteobacteria,1WWKX@135613|Chromatiales	135613|Chromatiales	LU	TIGRFAM DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_5322023_8	472759.Nhal_3813	1.374e-54	195.0	COG2922@1|root,COG2922@2|Bacteria,1RD5F@1224|Proteobacteria,1S43X@1236|Gammaproteobacteria,1WYZ6@135613|Chromatiales	135613|Chromatiales	S	Belongs to the Smg family	smg	-	-	ko:K03747	-	-	-	-	ko00000	-	-	-	DUF494
HKD1_k127_5322023_5	1123253.AUBD01000002_gene1204	2.749e-84	283.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,1RNZ2@1236|Gammaproteobacteria,1X3EQ@135614|Xanthomonadales	135614|Xanthomonadales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt
HKD1_k127_5328828_2	1123368.AUIS01000007_gene2702	1.101e-89	302.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,2NCX3@225057|Acidithiobacillales	225057|Acidithiobacillales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	LysM,YkuD
HKD1_k127_5328828_0	472759.Nhal_2517	3.139e-250	784.0	COG0443@1|root,COG0443@2|Bacteria,1Q5TZ@1224|Proteobacteria,1RZCY@1236|Gammaproteobacteria,1WWTR@135613|Chromatiales	135613|Chromatiales	O	heat shock protein 70	-	-	-	-	-	-	-	-	-	-	-	iECO26_1355.ECO26_0725	HSP70
HKD1_k127_5328828_3	472759.Nhal_2516	2.472e-50	187.0	COG0576@1|root,COG0576@2|Bacteria,1MZ1K@1224|Proteobacteria,1S8FS@1236|Gammaproteobacteria,1WYGW@135613|Chromatiales	135613|Chromatiales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_5328828_5	472759.Nhal_2515	4.846e-23	102.0	COG0484@1|root,COG0484@2|Bacteria,1NHTD@1224|Proteobacteria,1SCW2@1236|Gammaproteobacteria,1WZHI@135613|Chromatiales	135613|Chromatiales	O	PFAM heat shock protein DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD1_k127_5328828_1	472759.Nhal_2514	7.465e-142	481.0	COG0457@1|root,COG0457@2|Bacteria,1R87H@1224|Proteobacteria,1RYZI@1236|Gammaproteobacteria,1WXNT@135613|Chromatiales	135613|Chromatiales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5328828_4	1121127.JAFA01000003_gene1942	4.818e-41	156.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2VHJN@28216|Betaproteobacteria,1K1HD@119060|Burkholderiaceae	28216|Betaproteobacteria	C	permease	glcA	-	-	ko:K00427,ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14,2.A.14.1.1	-	-	Lactate_perm
HKD1_k127_5328828_6	743720.Psefu_3610	5.817e-17	81.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,1RPNW@1236|Gammaproteobacteria,1YY94@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	L-lactate permease	glcA	-	-	ko:K02550,ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14,2.A.14.1.2	-	-	Lactate_perm
HKD1_k127_5332068_0	1286631.X805_40900	6.245e-123	423.0	COG0457@1|root,COG4783@1|root,COG0457@2|Bacteria,COG4783@2|Bacteria,1R3SH@1224|Proteobacteria,2VSU9@28216|Betaproteobacteria,1KMSI@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_10
HKD1_k127_5332068_3	511.JT27_13345	2.058e-65	229.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2VQ06@28216|Betaproteobacteria,3T3JQ@506|Alcaligenaceae	28216|Betaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_5332068_2	1415779.JOMH01000001_gene900	2.459e-88	301.0	COG1560@1|root,COG1560@2|Bacteria,1MVNI@1224|Proteobacteria,1RMZ5@1236|Gammaproteobacteria,1X3W9@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)- (lauroyl)-lipid IV(A)	lpxL	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD1_k127_5332068_1	637389.Acaty_c0836	9.876e-96	319.0	COG1043@1|root,COG1043@2|Bacteria,1MUHQ@1224|Proteobacteria,1RPHB@1236|Gammaproteobacteria,2NBS7@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_5336460_0	765911.Thivi_4566	2.68e-188	599.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria,1X2E1@135613|Chromatiales	135613|Chromatiales	L	PFAM Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD1_k127_5336460_1	1123504.JQKD01000013_gene994	7.437e-05	47.0	COG3547@1|root,COG3547@2|Bacteria,1RBIF@1224|Proteobacteria,2VTT0@28216|Betaproteobacteria,4AI9Y@80864|Comamonadaceae	28216|Betaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_5374918_1	396588.Tgr7_3215	2.461e-64	224.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,1RN44@1236|Gammaproteobacteria,1WWQ1@135613|Chromatiales	135613|Chromatiales	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_5374918_0	472759.Nhal_0070	2.159e-196	626.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,1RMXX@1236|Gammaproteobacteria,1WWAE@135613|Chromatiales	135613|Chromatiales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD1_k127_5374918_8	743722.Sph21_3184	5.635e-11	65.0	COG0493@1|root,COG0493@2|Bacteria,4NG9R@976|Bacteroidetes,1IPJB@117747|Sphingobacteriia	976|Bacteroidetes	C	TIGRFAM glutamate synthase, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_5374918_2	589865.DaAHT2_1408	7.318e-52	185.0	COG3093@1|root,COG3093@2|Bacteria,1N76J@1224|Proteobacteria,42VQB@68525|delta/epsilon subdivisions,2WQFH@28221|Deltaproteobacteria,2MKMC@213118|Desulfobacterales	28221|Deltaproteobacteria	K	TIGRFAM addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HKD1_k127_5374918_3	589865.DaAHT2_1407	2.667e-41	153.0	COG3549@1|root,COG3549@2|Bacteria,1MZKX@1224|Proteobacteria,42VG7@68525|delta/epsilon subdivisions,2WRNJ@28221|Deltaproteobacteria,2MKJ5@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Plasmid maintenance system killer	-	-	-	ko:K07334	-	-	-	-	ko00000,ko02048	-	-	-	HigB-like_toxin
HKD1_k127_5374918_4	76114.ebA6736	2.209e-37	149.0	COG0277@1|root,COG0277@2|Bacteria,1MUPW@1224|Proteobacteria,2VI8J@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM FAD linked oxidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	BBE,FAD_binding_4
HKD1_k127_537810_9	118168.MC7420_1081	3.941e-54	202.0	COG4636@1|root,COG4636@2|Bacteria,1G1QP@1117|Cyanobacteria,1H79S@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_537810_6	1112217.PPL19_06395	9.455e-96	325.0	COG1466@1|root,COG1466@2|Bacteria,1MWYT@1224|Proteobacteria,1RQRE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	dna polymerase III delta subunit	holA	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009360,GO:0009987,GO:0032991,GO:0034641,GO:0034645,GO:0042575,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0061695,GO:0071704,GO:0090304,GO:1901360,GO:1901576,GO:1902494,GO:1990234	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delt_C,DNA_pol3_delta
HKD1_k127_537810_15	1288494.EBAPG3_5100	8.312e-13	76.0	COG2980@1|root,COG2980@2|Bacteria,1N13K@1224|Proteobacteria,2VU54@28216|Betaproteobacteria,3738A@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane	lptE	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HKD1_k127_537810_0	472759.Nhal_0537	0.0	1174.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,1RP14@1236|Gammaproteobacteria,1WW5E@135613|Chromatiales	135613|Chromatiales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_537810_4	1121921.KB898706_gene3279	1.334e-115	381.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,1RNHC@1236|Gammaproteobacteria,2PN4V@256005|Alteromonadales genera incertae sedis	1236|Gammaproteobacteria	O	UbiA prenyltransferase family	cyoE	GO:0003674,GO:0003824,GO:0004311,GO:0004659,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0015980,GO:0016020,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044464,GO:0045333,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	iJN746.PP_0110	UbiA
HKD1_k127_537810_13	105559.Nwat_3092	5.047e-27	118.0	COG1999@1|root,COG1999@2|Bacteria,1N6R6@1224|Proteobacteria,1SWXH@1236|Gammaproteobacteria,1X1CE@135613|Chromatiales	135613|Chromatiales	S	signal sequence binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_537810_11	1260251.SPISAL_01515	8.141e-49	184.0	COG3346@1|root,COG3346@2|Bacteria,1MZUH@1224|Proteobacteria,1S8S0@1236|Gammaproteobacteria,1WYUV@135613|Chromatiales	135613|Chromatiales	S	SURF1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	SURF1
HKD1_k127_537810_14	297246.lpp0475	1.382e-14	75.0	2EGIJ@1|root,33AAQ@2|Bacteria,1NH9B@1224|Proteobacteria,1SGKJ@1236|Gammaproteobacteria,1JFAY@118969|Legionellales	118969|Legionellales	S	Protein of unknown function (DUF2909)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2909
HKD1_k127_537810_3	472759.Nhal_0064	1.825e-133	430.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,1RN9D@1236|Gammaproteobacteria,1WX89@135613|Chromatiales	135613|Chromatiales	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_537810_8	472759.Nhal_0063	5.774e-55	199.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,1S5XA@1236|Gammaproteobacteria,1X0T0@135613|Chromatiales	135613|Chromatiales	O	PFAM Cytochrome c oxidase assembly protein CtaG Cox11	-	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD1_k127_537810_1	713586.KB900536_gene1818	4.037e-294	908.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,1RPC3@1236|Gammaproteobacteria,1WWX1@135613|Chromatiales	135613|Chromatiales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_537810_5	1179778.PMM47T1_07261	3.372e-105	348.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,1RP4H@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	coxB	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrome_CBB3
HKD1_k127_537810_12	323261.Noc_3048	2.413e-34	137.0	COG5488@1|root,COG5488@2|Bacteria,1N9B7@1224|Proteobacteria,1SF1J@1236|Gammaproteobacteria,1X1FG@135613|Chromatiales	135613|Chromatiales	S	Integral membrane protein (DUF2244)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2244
HKD1_k127_537810_7	572477.Alvin_0522	3.664e-71	249.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,1RSHS@1236|Gammaproteobacteria,1WXWI@135613|Chromatiales	135613|Chromatiales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	6.3.3.3	ko:K01935	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03182	RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HKD1_k127_537810_10	251221.35212959	3.724e-51	183.0	COG3268@1|root,COG3268@2|Bacteria,1G3XG@1117|Cyanobacteria	1117|Cyanobacteria	S	Saccharopine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Sacchrp_dh_NADP
HKD1_k127_537810_2	316057.RPD_1049	6.548e-150	483.0	COG1454@1|root,COG1454@2|Bacteria,1MVPH@1224|Proteobacteria,2TUHD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	alcohol dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_5415018_3	1463821.JOGR01000010_gene4050	4.359e-132	432.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria	201174|Actinobacteria	C	Belongs to the citrate synthase family	prpC	GO:0003674,GO:0003824,GO:0006082,GO:0006629,GO:0006631,GO:0008150,GO:0008152,GO:0009987,GO:0016740,GO:0016746,GO:0016999,GO:0017144,GO:0019541,GO:0019679,GO:0019752,GO:0032787,GO:0036440,GO:0043436,GO:0044237,GO:0044238,GO:0044255,GO:0044281,GO:0046459,GO:0046912,GO:0050440,GO:0071704	2.3.3.1,2.3.3.5	ko:K01647,ko:K01659	ko00020,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00640,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351,R00931	RC00004,RC00067,RC00406,RC02827	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_5415018_4	1123514.KB905899_gene871	2.389e-91	303.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,1RMCD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006244,GO:0006253,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008829,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009147,GO:0009149,GO:0009166,GO:0009200,GO:0009204,GO:0009211,GO:0009213,GO:0009219,GO:0009223,GO:0009262,GO:0009264,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0015949,GO:0016787,GO:0016810,GO:0016814,GO:0018130,GO:0019239,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046065,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072529,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO1525	DCD,dUTPase
HKD1_k127_5415018_1	2340.JV46_06490	3.532e-169	537.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,1RMJF@1236|Gammaproteobacteria,1J4F3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD1_k127_5415018_5	207954.MED92_12064	4.784e-57	204.0	COG1335@1|root,COG1335@2|Bacteria,1MU5N@1224|Proteobacteria,1S7F3@1236|Gammaproteobacteria,1XJ6U@135619|Oceanospirillales	135619|Oceanospirillales	Q	COG1335 Amidases related to nicotinamidase	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD1_k127_5415018_2	1049564.TevJSym_as00150	9.331e-151	499.0	COG0586@1|root,COG0586@2|Bacteria,1R0F3@1224|Proteobacteria,1RPDS@1236|Gammaproteobacteria,1JAB5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	I	Acid phosphatase homologues	lssY	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	LssY_C,PAP2,SNARE_assoc
HKD1_k127_5415018_0	395493.BegalDRAFT_3412	3.475e-260	807.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,1RSCT@1236|Gammaproteobacteria,4624S@72273|Thiotrichales	72273|Thiotrichales	C	Aldehyde ferredoxin oxidoreductase, N-terminal domain	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_5418388_0	338969.Rfer_3895	1.036e-166	539.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_5418388_1	243233.MCA0768	1.506e-135	439.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,1RRTA@1236|Gammaproteobacteria,1XDK5@135618|Methylococcales	135618|Methylococcales	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5418388_2	243233.MCA0769	6.116e-124	399.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,1MVM0@1224|Proteobacteria,1RNNX@1236|Gammaproteobacteria,1XE3B@135618|Methylococcales	135618|Methylococcales	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	-	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_5439968_3	349521.HCH_00962	1.651e-126	409.0	COG1492@1|root,COG1492@2|Bacteria,1MUFY@1224|Proteobacteria,1RP8G@1236|Gammaproteobacteria,1XHE6@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_5439968_7	243365.CV_1575	1.63e-104	359.0	COG1270@1|root,COG1270@2|Bacteria,1MURM@1224|Proteobacteria,2VIDF@28216|Betaproteobacteria,2KPJI@206351|Neisseriales	206351|Neisseriales	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	-	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
HKD1_k127_5439968_4	1266908.AQPB01000052_gene773	7.055e-120	393.0	COG0079@1|root,COG0079@2|Bacteria,1MXDP@1224|Proteobacteria,1RR2V@1236|Gammaproteobacteria,1WXH3@135613|Chromatiales	135613|Chromatiales	E	PFAM aminotransferase, class I	-	-	-	ko:K02225	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002	-	-	-	Aminotran_1_2
HKD1_k127_5439968_9	189753.AXAS01000004_gene956	1.556e-65	235.0	COG0457@1|root,COG0457@2|Bacteria,1NG0U@1224|Proteobacteria,2U0YA@28211|Alphaproteobacteria,3K0QN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_5439968_2	631362.Thi970DRAFT_03873	1.432e-167	535.0	COG1449@1|root,COG1449@2|Bacteria,1R5KI@1224|Proteobacteria,1S0ID@1236|Gammaproteobacteria,1WXJ4@135613|Chromatiales	135613|Chromatiales	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_57
HKD1_k127_5439968_0	396588.Tgr7_1241	1.268e-191	602.0	COG0082@1|root,COG0082@2|Bacteria,1MU98@1224|Proteobacteria,1RMQS@1236|Gammaproteobacteria,1WXNW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD1_k127_5439968_5	396588.Tgr7_1243	3.239e-117	389.0	COG0477@1|root,COG2814@2|Bacteria,1MVZI@1224|Proteobacteria,1RPBT@1236|Gammaproteobacteria,1WWHF@135613|Chromatiales	135613|Chromatiales	EGP	Major facilitator superfamily	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1_like
HKD1_k127_5439968_8	572547.Amico_1593	7.961e-69	239.0	COG2110@1|root,COG2110@2|Bacteria,3TBCJ@508458|Synergistetes	508458|Synergistetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD1_k127_5439968_11	237368.SCABRO_02026	5.832e-26	108.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	ko:K07339	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HicA_toxin
HKD1_k127_5439968_10	472759.Nhal_1261	1.144e-29	118.0	COG1598@1|root,COG1598@2|Bacteria,1NNW6@1224|Proteobacteria,1STP0@1236|Gammaproteobacteria,1X1YA@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5439968_1	1191523.MROS_0770	2.631e-187	610.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	prc	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DUF3340,PDZ,Peptidase_S41
HKD1_k127_5439968_6	395493.BegalDRAFT_1056	8.614e-114	373.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,NYN
HKD1_k127_5439968_12	1151117.AJLF01000001_gene1112	1.779e-18	98.0	COG0574@1|root,arCOG01111@2157|Archaea,2XU2T@28890|Euryarchaeota,242QQ@183968|Thermococci	183968|Thermococci	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	ppsA	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_5452019_1	384765.SIAM614_05351	1.261e-198	627.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TRNK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_5452019_3	1167006.UWK_02676	6.285e-166	538.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,42NY8@68525|delta/epsilon subdivisions,2WJNT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	gamma-glutamyltransferase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_5452019_2	187272.Mlg_2070	3.225e-191	604.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,1RMWA@1236|Gammaproteobacteria,1WWMG@135613|Chromatiales	135613|Chromatiales	L	DEAD-box RNA helicase involved in RNA degradation. Has RNA-dependent ATPase activity and unwinds double-stranded RNA	rhlB	-	3.6.4.13	ko:K03732	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_5452019_5	349124.Hhal_2056	1.694e-52	188.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WY87@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_5452019_0	187272.Mlg_0367	1.156e-236	735.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,1RP95@1236|Gammaproteobacteria,1WW22@135613|Chromatiales	135613|Chromatiales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD1_k127_5452019_4	1348635.BBJY01000026_gene2302	2.94e-96	317.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,1RNS4@1236|Gammaproteobacteria,1XT9Q@135623|Vibrionales	135623|Vibrionales	F	Belongs to the GARS family	purD	GO:0003674,GO:0003824,GO:0004637,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_5465438_2	111780.Sta7437_3490	2.667e-52	189.0	COG1569@1|root,COG1569@2|Bacteria,1G523@1117|Cyanobacteria,3VJT0@52604|Pleurocapsales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN_3
HKD1_k127_5465438_4	572477.Alvin_0642	1.073e-09	65.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_5465438_0	368407.Memar_0887	4.123e-144	465.0	COG0596@1|root,arCOG01648@2157|Archaea,2XUZM@28890|Euryarchaeota,2NB9P@224756|Methanomicrobia	224756|Methanomicrobia	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_5465438_3	221288.JH992900_gene140	1.382e-30	126.0	COG4644@1|root,COG4644@2|Bacteria,1G1DD@1117|Cyanobacteria	1117|Cyanobacteria	L	COG4644 Transposase and inactivated derivatives TnpA family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HKD1_k127_5465438_1	1116472.MGMO_15c00450	7.467e-83	281.0	COG4644@1|root,COG4644@2|Bacteria,1MUIU@1224|Proteobacteria,1RPZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HKD1_k127_5534217_7	886293.Sinac_4049	2.796e-62	218.0	COG0783@1|root,COG0783@2|Bacteria,2IZJP@203682|Planctomycetes	203682|Planctomycetes	P	Belongs to the Dps family	-	-	-	ko:K04047	-	-	-	-	ko00000,ko03036	-	-	-	Ferritin
HKD1_k127_5534217_4	1095769.CAHF01000011_gene2295	1.198e-101	335.0	COG0655@1|root,COG0655@2|Bacteria,1MW7N@1224|Proteobacteria,2VJF5@28216|Betaproteobacteria,475X1@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD1_k127_5534217_12	497964.CfE428DRAFT_5617	7.283e-05	48.0	COG1028@1|root,COG1028@2|Bacteria,46U52@74201|Verrucomicrobia	74201|Verrucomicrobia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_5534217_2	1121405.dsmv_1298	3.78e-140	454.0	COG1032@1|root,COG1032@2|Bacteria,1PTN9@1224|Proteobacteria,42MG9@68525|delta/epsilon subdivisions,2WJYU@28221|Deltaproteobacteria,2MIRY@213118|Desulfobacterales	28221|Deltaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_5534217_6	1094715.CM001375_gene214	2.092e-62	220.0	COG0582@1|root,COG0582@2|Bacteria,1RD46@1224|Proteobacteria,1SAM2@1236|Gammaproteobacteria,1JDR1@118969|Legionellales	118969|Legionellales	L	Phage integrase family	xerC_1	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_5534217_10	457398.HMPREF0326_02678	4.635e-11	69.0	29XH1@1|root,30J7N@2|Bacteria,1PYPQ@1224|Proteobacteria,432AE@68525|delta/epsilon subdivisions	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD1_k127_5534217_11	1151292.QEW_3674	2.283e-05	49.0	COG0789@1|root,COG0789@2|Bacteria,1UJN5@1239|Firmicutes,25F65@186801|Clostridia	186801|Clostridia	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD1_k127_5534217_9	1458427.BAWN01000094_gene2210	4.717e-21	105.0	COG1196@1|root,COG1196@2|Bacteria,1NAE5@1224|Proteobacteria,2W0QG@28216|Betaproteobacteria	28216|Betaproteobacteria	D	Plasmid replication region DNA-binding N-term	-	-	-	-	-	-	-	-	-	-	-	-	KfrA_N
HKD1_k127_5534217_1	765420.OSCT_1549	4.296e-185	592.0	COG0154@1|root,COG0154@2|Bacteria,2G7WJ@200795|Chloroflexi,3771Y@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the amidase family	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD1_k127_5534217_5	404380.Gbem_2210	5.429e-77	265.0	COG1136@1|root,COG1136@2|Bacteria,1NCFC@1224|Proteobacteria,42RPV@68525|delta/epsilon subdivisions,2WNQC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5534217_0	1128421.JAGA01000003_gene3139	1.631e-204	666.0	COG0577@1|root,COG0577@2|Bacteria,2NQQA@2323|unclassified Bacteria	2|Bacteria	V	MacB-like periplasmic core domain	salY	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_5534217_3	357808.RoseRS_0065	1.19e-131	430.0	COG5621@1|root,COG5621@2|Bacteria,2G6EI@200795|Chloroflexi,374YJ@32061|Chloroflexia	32061|Chloroflexia	S	Lipocalin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CrtC,Lipocalin_9
HKD1_k127_5534217_13	697282.Mettu_3881	0.0006068	47.0	2DIE3@1|root,302Y1@2|Bacteria,1QPR0@1224|Proteobacteria,1SJHJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD1_k127_5534217_8	118168.MC7420_4384	2.712e-39	149.0	COG1716@1|root,COG5635@1|root,COG1716@2|Bacteria,COG5635@2|Bacteria,1G192@1117|Cyanobacteria,1H737@1150|Oscillatoriales	1117|Cyanobacteria	T	Ntpase (Nacht family)	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,TIR_2
HKD1_k127_554558_6	102129.Lepto7375DRAFT_7471	0.0008573	46.0	COG0775@1|root,COG1262@1|root,COG5635@1|root,COG0775@2|Bacteria,COG1262@2|Bacteria,COG5635@2|Bacteria	2|Bacteria	T	Nacht domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,HEAT_2,HEAT_PBS,NACHT,PNP_UDP_1
HKD1_k127_554558_5	522306.CAP2UW1_2323	4.676e-06	56.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria,2W0EW@28216|Betaproteobacteria	28216|Betaproteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
HKD1_k127_554558_2	671143.DAMO_1988	1.823e-24	112.0	COG1262@1|root,COG1262@2|Bacteria,2NR8C@2323|unclassified Bacteria	2|Bacteria	S	Sulfatase-modifying factor enzyme 1	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase
HKD1_k127_554558_4	1269813.ATUL01000055_gene63	4.025e-09	60.0	COG1943@1|root,COG1943@2|Bacteria,1MZZT@1224|Proteobacteria,1S9JG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_554558_3	396588.Tgr7_2777	1.176e-20	94.0	COG1943@1|root,COG1943@2|Bacteria,1MZZT@1224|Proteobacteria,1S9JG@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG1943 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_554558_0	1279038.KB907338_gene979	6.285e-284	878.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2JQVU@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_554558_1	1279038.KB907338_gene980	7.165e-57	200.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD1_k127_5560064_3	111781.Lepto7376_4051	7.997e-47	173.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HEKZ@1150|Oscillatoriales	1117|Cyanobacteria	L	SPTR Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
HKD1_k127_5560064_1	563192.HMPREF0179_02675	1.404e-207	652.0	COG1630@1|root,COG1630@2|Bacteria,1N313@1224|Proteobacteria,42YIN@68525|delta/epsilon subdivisions,2WUPF@28221|Deltaproteobacteria,2MEBD@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NurA	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5560064_0	665942.HMPREF1022_00553	0.0	1169.0	COG0433@1|root,COG0433@2|Bacteria,1R7TJ@1224|Proteobacteria,42XP2@68525|delta/epsilon subdivisions,2WSTV@28221|Deltaproteobacteria,2MEGI@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF87
HKD1_k127_5560064_2	563192.HMPREF0179_02677	5.045e-164	522.0	COG0863@1|root,COG0863@2|Bacteria,1RAQD@1224|Proteobacteria,42YYC@68525|delta/epsilon subdivisions,2WTM1@28221|Deltaproteobacteria,2MEH0@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	DNA methylase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_5560064_4	322710.Avin_14300	4.597e-38	145.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RP5P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	hmm pf02371	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_5561214_2	485913.Krac_7449	3.245e-37	143.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_5561214_1	485913.Krac_7449	6.021e-55	197.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_5561214_0	485913.Krac_7449	2.584e-153	492.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_557686_4	1041147.AUFB01000014_gene243	1.513e-10	63.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,4B9CX@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	efflux pump	MA20_01135	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_557686_1	1095769.CAHF01000022_gene346	8.334e-56	198.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,473CA@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	MMPL family	bepE	-	-	ko:K18138,ko:K18902	ko01501,ko01503,map01501,map01503	M00647,M00698,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_557686_5	1255043.TVNIR_2929	0.0005464	46.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_557686_0	330214.NIDE0029	2.292e-237	753.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat
HKD1_k127_557686_3	715451.ambt_22005	4.078e-44	163.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,469D0@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
HKD1_k127_557686_2	715451.ambt_22005	2.335e-52	189.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,1RN63@1236|Gammaproteobacteria,469D0@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	COG4096 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases	hsdR	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
HKD1_k127_5588393_3	396588.Tgr7_0530	2.808e-52	188.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,1RMBI@1236|Gammaproteobacteria,1WWWF@135613|Chromatiales	135613|Chromatiales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD1_k127_5588393_1	396588.Tgr7_0529	2.356e-67	234.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,1RPK3@1236|Gammaproteobacteria,1WWEP@135613|Chromatiales	135613|Chromatiales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD1_k127_5588393_0	519989.ECTPHS_02441	1.579e-70	244.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,1S46A@1236|Gammaproteobacteria,1WYEN@135613|Chromatiales	135613|Chromatiales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD1_k127_5588393_2	765914.ThisiDRAFT_0700	2.91e-63	220.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,1RMUC@1236|Gammaproteobacteria,1WWSB@135613|Chromatiales	135613|Chromatiales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD1_k127_5588483_4	1249627.D779_3417	3.543e-68	234.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,1RMEM@1236|Gammaproteobacteria,1WXQ7@135613|Chromatiales	135613|Chromatiales	E	ABC transporter	-	-	-	ko:K11963	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran
HKD1_k127_5588483_1	1123242.JH636435_gene2321	3.094e-164	522.0	COG1023@1|root,COG1023@2|Bacteria,2IYCD@203682|Planctomycetes	203682|Planctomycetes	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD1_k127_5588483_6	1192034.CAP_0277	0.0005322	47.0	COG0406@1|root,COG0406@2|Bacteria,1RHAT@1224|Proteobacteria,42SUD@68525|delta/epsilon subdivisions,2WP5H@28221|Deltaproteobacteria,2Z2DD@29|Myxococcales	28221|Deltaproteobacteria	G	Phosphoglycerate mutase family	-	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD1_k127_5588483_5	247490.KSU1_B0459	1.555e-63	228.0	COG0363@1|root,COG0363@2|Bacteria,2J0I5@203682|Planctomycetes	203682|Planctomycetes	G	Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD1_k127_5588483_0	269799.Gmet_3493	0.0	1141.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,42NBM@68525|delta/epsilon subdivisions,2WKTG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	PFAM Cytochrome c oxidase, subunit I	norZ	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD1_k127_5588483_3	1185652.USDA257_c56260	1.466e-78	269.0	COG4089@1|root,COG4089@2|Bacteria,1MV8K@1224|Proteobacteria,2U3GA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1614)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1614
HKD1_k127_5588483_2	1095769.CAHF01000006_gene1913	1.241e-100	331.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,475IE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_5594680_1	63737.Npun_R0572	8.595e-18	85.0	COG4221@1|root,COG4221@2|Bacteria,1G2X4@1117|Cyanobacteria,1HSGD@1161|Nostocales	1117|Cyanobacteria	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_5594680_0	522306.CAP2UW1_0699	1.198e-186	597.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_5594680_2	489825.LYNGBM3L_22820	1.522e-17	86.0	COG3415@1|root,COG3415@2|Bacteria,1GQZ0@1117|Cyanobacteria,1HI55@1150|Oscillatoriales	1117|Cyanobacteria	L	Homeodomain-like domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,HTH_33
HKD1_k127_5617244_1	1122604.JONR01000009_gene2466	0.0004605	44.0	COG1566@1|root,COG1566@2|Bacteria,1MXZV@1224|Proteobacteria,1S2IJ@1236|Gammaproteobacteria,1X764@135614|Xanthomonadales	135614|Xanthomonadales	V	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_5617244_0	1249627.D779_2313	2.43e-170	542.0	COG0073@1|root,COG0143@1|root,COG0073@2|Bacteria,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,1RMYM@1236|Gammaproteobacteria,1WWU6@135613|Chromatiales	135613|Chromatiales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD1_k127_5631457_0	396588.Tgr7_3000	2.137e-201	630.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,1RM7I@1236|Gammaproteobacteria,1WXK9@135613|Chromatiales	135613|Chromatiales	C	Belongs to the heme-copper respiratory oxidase family	-	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HKD1_k127_5631457_2	713586.KB900536_gene1809	1.377e-120	392.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,1RPU6@1236|Gammaproteobacteria,1WWMH@135613|Chromatiales	135613|Chromatiales	C	PFAM Cytochrome C oxidase, monoheme subunit FixO	-	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD1_k127_5631457_3	396588.Tgr7_2997	6.283e-109	363.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,1RPYJ@1236|Gammaproteobacteria,1WWRW@135613|Chromatiales	135613|Chromatiales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	-	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD1_k127_5631457_1	396588.Tgr7_2996	3.633e-193	612.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,1RMDI@1236|Gammaproteobacteria,1WWVW@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM cytochrome c oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD1_k127_5631457_5	1219375.CM002139_gene873	8.055e-05	46.0	COG5007@1|root,COG5007@2|Bacteria,1R3MK@1224|Proteobacteria,1SE4M@1236|Gammaproteobacteria,1X7EE@135614|Xanthomonadales	135614|Xanthomonadales	K	Belongs to the BolA IbaG family	SN15_13775	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD1_k127_5632182_2	323261.Noc_1987	1.534e-84	305.0	COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1WX0E@135613|Chromatiales	135613|Chromatiales	U	PEP-CTERM system TPR-repeat lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_8
HKD1_k127_5632182_1	1430440.MGMSRv2_3152	1.94e-293	906.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2JQVU@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_5632182_0	1121033.AUCF01000013_gene1599	2.601e-298	928.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2JPYX@204441|Rhodospirillales	204441|Rhodospirillales	I	COG4770 Acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD1_k127_5632182_3	243233.MCA2827	3.214e-63	221.0	COG2236@1|root,COG2236@2|Bacteria,1RKB0@1224|Proteobacteria,1S7J1@1236|Gammaproteobacteria,1XFMX@135618|Methylococcales	135618|Methylococcales	F	Phosphoribosyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_5654456_1	472759.Nhal_3432	6.277e-119	411.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,1WXR1@135613|Chromatiales	135613|Chromatiales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_4,dCache_3
HKD1_k127_5654456_2	395493.BegalDRAFT_1623	2.45e-81	276.0	COG0500@1|root,COG2226@2|Bacteria,1MVSY@1224|Proteobacteria,1S24V@1236|Gammaproteobacteria,460IK@72273|Thiotrichales	72273|Thiotrichales	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	MetW
HKD1_k127_5654456_0	395493.BegalDRAFT_1624	6.424e-195	617.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RQ2N@1236|Gammaproteobacteria,45ZWM@72273|Thiotrichales	72273|Thiotrichales	E	Transfers a succinyl group from succinyl-CoA to L- homoserine, forming succinyl-L-homoserine	metXS	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_5654456_5	323261.Noc_3000	1.207e-24	110.0	COG1872@1|root,COG1872@2|Bacteria,1MZ4E@1224|Proteobacteria,1S9AB@1236|Gammaproteobacteria,1WYTV@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD1_k127_5654456_4	314278.NB231_13266	3.084e-46	173.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,1WXC6@135613|Chromatiales	135613|Chromatiales	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD1_k127_5654456_3	314278.NB231_13271	3.501e-71	244.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,1RNQK@1236|Gammaproteobacteria,1WWVS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD1_k127_5688114_8	1046724.KB889921_gene118	6.828e-26	114.0	COG0664@1|root,COG0664@2|Bacteria,1NCGM@1224|Proteobacteria	1224|Proteobacteria	T	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_5688114_1	1458357.BG58_18250	1.607e-111	364.0	COG0607@1|root,COG0640@1|root,COG0607@2|Bacteria,COG0640@2|Bacteria,1R71B@1224|Proteobacteria,2VI9S@28216|Betaproteobacteria,1K7KF@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Rhodanese
HKD1_k127_5688114_6	1158292.JPOE01000005_gene886	1.872e-39	153.0	COG1553@1|root,COG1553@2|Bacteria,1RDFR@1224|Proteobacteria,2VSFK@28216|Betaproteobacteria,1KP1A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	P	DsrE/DsrF-like family	-	-	-	ko:K06039	-	-	-	-	ko00000	-	-	-	DrsE
HKD1_k127_5688114_5	358220.C380_05855	4.497e-55	199.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VP0A@28216|Betaproteobacteria,4AHHH@80864|Comamonadaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_5688114_10	381666.H16_A2209	1.59e-11	68.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2VP0A@28216|Betaproteobacteria,1K90G@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_5688114_3	395961.Cyan7425_0025	7.473e-70	240.0	COG4644@1|root,COG4644@2|Bacteria,1G1K1@1117|Cyanobacteria,3KJTB@43988|Cyanothece	1117|Cyanobacteria	L	Tn3 transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HKD1_k127_5688114_2	1504672.669783337	1.659e-96	320.0	COG3335@1|root,COG3335@2|Bacteria,1NWV8@1224|Proteobacteria	1224|Proteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_5688114_7	485913.Krac_7611	2.782e-39	152.0	COG3415@1|root,COG3415@2|Bacteria,2G8GG@200795|Chloroflexi	2|Bacteria	L	InterPro IPR009057	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_29,HTH_32
HKD1_k127_5688114_9	56107.Cylst_5603	2.126e-12	73.0	COG4644@1|root,COG4644@2|Bacteria,1G1K1@1117|Cyanobacteria,1HMWR@1161|Nostocales	1117|Cyanobacteria	L	Tn3 transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_Tn3,DUF4158
HKD1_k127_5688114_11	1499967.BAYZ01000019_gene6280	4.761e-07	55.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD1_k127_5688114_12	1173264.KI913949_gene1297	2.702e-06	50.0	COG3293@1|root,COG3293@2|Bacteria,1G0BW@1117|Cyanobacteria,1HDZD@1150|Oscillatoriales	1117|Cyanobacteria	L	Transposase DDE domain	-	-	-	ko:K07492	-	-	-	-	ko00000	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD1_k127_5688114_0	1380347.JNII01000006_gene1902	2.22e-124	417.0	COG2132@1|root,COG2132@2|Bacteria,2GMJ4@201174|Actinobacteria	201174|Actinobacteria	Q	Multicopper oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase_2,Cu-oxidase_3
HKD1_k127_5688114_4	365044.Pnap_2499	4.086e-63	228.0	COG3464@1|root,COG3464@2|Bacteria,1R8HI@1224|Proteobacteria,2VT67@28216|Betaproteobacteria,4AJPQ@80864|Comamonadaceae	28216|Betaproteobacteria	L	TrfA protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,TrfA
HKD1_k127_5688205_1	1265505.ATUG01000002_gene1059	5.36e-163	522.0	COG0784@1|root,COG4191@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WK3J@28221|Deltaproteobacteria,2MI5F@213118|Desulfobacterales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,SBP_bac_3
HKD1_k127_5688205_9	1123227.KB899349_gene842	7.797e-14	73.0	COG0500@1|root,COG2226@2|Bacteria,1MVXG@1224|Proteobacteria,2U8IJ@28211|Alphaproteobacteria,2JWHR@204441|Rhodospirillales	204441|Rhodospirillales	Q	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_5688205_7	1442599.JAAN01000040_gene3001	5.404e-16	82.0	COG0764@1|root,COG0764@2|Bacteria,1NGGK@1224|Proteobacteria,1SJ6T@1236|Gammaproteobacteria,1X7W5@135614|Xanthomonadales	135614|Xanthomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	FabA
HKD1_k127_5688205_3	765913.ThidrDRAFT_3310	2.429e-111	376.0	COG0318@1|root,COG0318@2|Bacteria,1MXPB@1224|Proteobacteria,1RRD5@1236|Gammaproteobacteria,1WW42@135613|Chromatiales	135613|Chromatiales	IQ	AMP-binding enzyme	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_5688205_6	768671.ThimaDRAFT_2058	5.111e-24	106.0	COG1434@1|root,COG1434@2|Bacteria,1MVW8@1224|Proteobacteria,1RNZC@1236|Gammaproteobacteria,1WYB6@135613|Chromatiales	135613|Chromatiales	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_5688205_8	583345.Mmol_0373	2.464e-14	77.0	COG0695@1|root,COG0695@2|Bacteria,1PJM1@1224|Proteobacteria,2W6D1@28216|Betaproteobacteria,2KNCR@206350|Nitrosomonadales	206350|Nitrosomonadales	O	PFAM glutaredoxin 2	-	-	-	-	-	-	-	-	-	-	-	-	DUF836
HKD1_k127_5688205_5	1244869.H261_22143	1.775e-64	226.0	2BNSJ@1|root,32HG4@2|Bacteria,1MV5R@1224|Proteobacteria,2U1AN@28211|Alphaproteobacteria,2JT39@204441|Rhodospirillales	204441|Rhodospirillales	S	Domain of unknown function (DUF4337)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4337
HKD1_k127_5688205_4	1173024.KI912154_gene1048	7.031e-97	334.0	COG2067@1|root,COG2067@2|Bacteria,1GBW9@1117|Cyanobacteria,1JJ8V@1189|Stigonemataceae	1117|Cyanobacteria	I	Outer membrane protein transport protein (OMPP1/FadL/TodX)	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Toluene_X
HKD1_k127_5688205_0	391008.Smal_1654	3.487e-286	899.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,1RMZ8@1236|Gammaproteobacteria,1X4BT@135614|Xanthomonadales	135614|Xanthomonadales	I	3-hydroxyacyl-coa dehydrogenase	fadB	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD1_k127_5688205_2	314278.NB231_07015	1.63e-161	516.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,1RM93@1236|Gammaproteobacteria,1X07U@135613|Chromatiales	135613|Chromatiales	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_5696313_4	1123256.KB907927_gene1587	2.836e-28	118.0	COG2005@1|root,COG3585@1|root,COG2005@2|Bacteria,COG3585@2|Bacteria,1P9SX@1224|Proteobacteria,1RMES@1236|Gammaproteobacteria,1X6JX@135614|Xanthomonadales	135614|Xanthomonadales	H	TOBE domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,TOBE
HKD1_k127_5696313_2	1123354.AUDR01000016_gene1343	4.398e-35	135.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,1KRT0@119069|Hydrogenophilales	119069|Hydrogenophilales	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_5696313_3	631362.Thi970DRAFT_04118	2.147e-33	131.0	COG1146@1|root,COG1146@2|Bacteria,1QW5F@1224|Proteobacteria,1T4WS@1236|Gammaproteobacteria,1WYJJ@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM ferredoxin III	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_5696313_1	395493.BegalDRAFT_0791	1.905e-53	193.0	COG1433@1|root,COG1433@2|Bacteria,1RD9P@1224|Proteobacteria,1S50W@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Pfam Dinitrogenase iron-molybdenum cofactor	nifX	-	-	ko:K02596	-	-	-	-	ko00000	-	-	-	Nitro_FeMo-Co
HKD1_k127_5696313_0	765914.ThisiDRAFT_1850	2.553e-55	198.0	COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,1RPBI@1236|Gammaproteobacteria,1WWZJ@135613|Chromatiales	135613|Chromatiales	C	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
HKD1_k127_5709729_1	870187.Thini_3411	3.061e-120	389.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,1RN2E@1236|Gammaproteobacteria,45ZQZ@72273|Thiotrichales	72273|Thiotrichales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	ATPase,ChlI
HKD1_k127_5709729_0	686340.Metal_3811	1.353e-162	517.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,1RNDC@1236|Gammaproteobacteria,1XDR0@135618|Methylococcales	135618|Methylococcales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD1_k127_5709729_3	589865.DaAHT2_0739	5.706e-78	267.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,42STM@68525|delta/epsilon subdivisions,2WPAD@28221|Deltaproteobacteria,2MKSG@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD1_k127_5709729_2	1265313.HRUBRA_00024	2.009e-91	305.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,1RNU8@1236|Gammaproteobacteria,1J4HA@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the SUA5 family	yciO	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Sua5_yciO_yrdC
HKD1_k127_5709729_4	1283300.ATXB01000002_gene3128	4.149e-69	238.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,1RQAB@1236|Gammaproteobacteria,1XF33@135618|Methylococcales	135618|Methylococcales	D	probably involved in intracellular septation	-	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD1_k127_5709729_5	1121035.AUCH01000002_gene1566	2.266e-29	117.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2VUM7@28216|Betaproteobacteria,2KWK7@206389|Rhodocyclales	206389|Rhodocyclales	S	YCII-related domain	-	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD1_k127_5738557_5	1286106.MPL1_09305	2.255e-31	126.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,45ZP0@72273|Thiotrichales	72273|Thiotrichales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_5738557_0	697282.Mettu_3036	6.933e-218	685.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,1RN3R@1236|Gammaproteobacteria,1XEG7@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_5738557_6	765911.Thivi_1912	1.539e-13	71.0	2ANKS@1|root,31DJZ@2|Bacteria,1R1SV@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5738557_1	1111479.AXAR01000012_gene1429	7.157e-107	357.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,4H9T0@91061|Bacilli,279BQ@186823|Alicyclobacillaceae	91061|Bacilli	S	Nitronate monooxygenase	npd	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD1_k127_5738557_4	314278.NB231_12696	5.791e-75	258.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,1S3PG@1236|Gammaproteobacteria,1WWUP@135613|Chromatiales	135613|Chromatiales	V	PFAM N-acetylmuramoyl-L-alanine amidase family 2	-	-	3.5.1.28	ko:K03806	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	Amidase_2
HKD1_k127_5738557_2	395493.BegalDRAFT_2643	8.914e-106	354.0	COG2307@1|root,COG2307@2|Bacteria,1MVZK@1224|Proteobacteria,1RN2Y@1236|Gammaproteobacteria,460JS@72273|Thiotrichales	72273|Thiotrichales	S	A predicted alpha-helical domain with a conserved ER motif.	-	-	-	-	-	-	-	-	-	-	-	-	Alpha-E
HKD1_k127_5738557_3	395493.BegalDRAFT_2644	8.993e-106	347.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,46043@72273|Thiotrichales	72273|Thiotrichales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD1_k127_5752057_0	357808.RoseRS_0609	2.172e-30	127.0	COG1477@1|root,COG1477@2|Bacteria,2G6WH@200795|Chloroflexi,375JB@32061|Chloroflexia	32061|Chloroflexia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD1_k127_5752057_1	525904.Tter_2127	8.1e-30	130.0	COG4097@1|root,COG4097@2|Bacteria	2|Bacteria	P	nitric oxide dioxygenase activity	-	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HKD1_k127_5752057_2	926550.CLDAP_06320	1.435e-09	59.0	COG0667@1|root,COG0667@2|Bacteria,2G5YU@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_5761067_0	396588.Tgr7_1275	1.365e-194	611.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,1RRTQ@1236|Gammaproteobacteria,1WWD8@135613|Chromatiales	135613|Chromatiales	O	Belongs to the HypD family	-	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD1_k127_5761067_1	237368.SCABRO_02048	1.495e-142	469.0	COG4974@1|root,COG4974@2|Bacteria,2IZG8@203682|Planctomycetes	203682|Planctomycetes	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_5770249_3	622637.KE124774_gene3496	1.573e-144	465.0	COG0664@1|root,COG0664@2|Bacteria,1MW6M@1224|Proteobacteria,2TRCA@28211|Alphaproteobacteria,36ZSP@31993|Methylocystaceae	28211|Alphaproteobacteria	T	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein	srpI	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_5770249_0	448385.sce4643	5.816e-216	689.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PJT@68525|delta/epsilon subdivisions,2WKPW@28221|Deltaproteobacteria,2YXCR@29|Myxococcales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_5770249_9	1238182.C882_4148	1.191e-37	152.0	COG0607@1|root,COG0607@2|Bacteria,1REHH@1224|Proteobacteria,2UBVU@28211|Alphaproteobacteria,2JTIC@204441|Rhodospirillales	204441|Rhodospirillales	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_5770249_5	926569.ANT_03920	5.014e-74	251.0	COG0031@1|root,COG0031@2|Bacteria,2G5PG@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_5770249_17	1452718.JBOY01000023_gene292	2.546e-13	72.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,1RNCA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	iJN746.PP_0840	Hexapep,SATase_N
HKD1_k127_5770249_18	979556.MTES_0423	2.195e-12	72.0	COG1045@1|root,COG1045@2|Bacteria,2IHW5@201174|Actinobacteria,4FNFM@85023|Microbacteriaceae	201174|Actinobacteria	E	Bacterial transferase hexapeptide (six repeats)	cysE	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006535,GO:0006563,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009001,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0016407,GO:0016412,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019344,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_5770249_20	312153.Pnuc_1336	1.051e-07	57.0	COG2998@1|root,COG2998@2|Bacteria,1MVSF@1224|Proteobacteria,2VJQG@28216|Betaproteobacteria,1K519@119060|Burkholderiaceae	28216|Betaproteobacteria	H	transporter	tupB	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_5770249_15	43989.cce_4896	2.081e-15	78.0	2DTC9@1|root,33JP3@2|Bacteria,1GB2W@1117|Cyanobacteria,3KK6A@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5770249_12	269796.Rru_A1069	1.059e-20	95.0	COG2000@1|root,COG2000@2|Bacteria,1NU4F@1224|Proteobacteria	1224|Proteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS
HKD1_k127_5770249_7	493475.GARC_3034	6.269e-58	211.0	arCOG10456@1|root,2ZA6T@2|Bacteria,1R4VS@1224|Proteobacteria,1S209@1236|Gammaproteobacteria,466KG@72275|Alteromonadaceae	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5770249_13	105559.Nwat_0065	1.184e-18	86.0	2DNRM@1|root,32YT2@2|Bacteria,1N8BS@1224|Proteobacteria,1T0VB@1236|Gammaproteobacteria,1WZ7K@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_5770249_14	105559.Nwat_0065	2.564e-17	82.0	2DNRM@1|root,32YT2@2|Bacteria,1N8BS@1224|Proteobacteria,1T0VB@1236|Gammaproteobacteria,1WZ7K@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_5770249_19	631362.Thi970DRAFT_03019	5.706e-11	64.0	COG3385@1|root,COG3385@2|Bacteria,1MXYG@1224|Proteobacteria,1S0CA@1236|Gammaproteobacteria,1WXQT@135613|Chromatiales	135613|Chromatiales	L	Transposase IS4 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4338,Dimer_Tnp_Tn5,Tnp_DNA_bind
HKD1_k127_5770249_11	426114.THI_3392	2.259e-22	98.0	2EJAI@1|root,33D1Q@2|Bacteria,1NHDC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1640
HKD1_k127_5770249_4	261292.Nit79A3_0263	1.828e-104	354.0	COG0582@1|root,COG0582@2|Bacteria,1N2H9@1224|Proteobacteria,2VT4R@28216|Betaproteobacteria,3723T@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_3,Phage_integrase
HKD1_k127_5770249_16	1288494.EBAPG3_2320	1.759e-14	73.0	COG0409@1|root,COG0409@2|Bacteria,1MU1F@1224|Proteobacteria,2VHKM@28216|Betaproteobacteria,3735W@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Hydrogenase formation hypA family	hypD	-	-	ko:K04654	-	-	-	-	ko00000	-	-	-	HypD
HKD1_k127_5770249_1	1123355.JHYO01000008_gene2679	6.189e-206	653.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,36ZEK@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_5770249_6	572477.Alvin_3110	1.268e-59	211.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,1S2AY@1236|Gammaproteobacteria,1WY14@135613|Chromatiales	135613|Chromatiales	T	PFAM Phosphoglycerate mutase	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD1_k127_5770249_2	331869.BAL199_30152	4.687e-171	543.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,4BPRI@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_5770249_8	713587.THITH_09575	1.294e-52	197.0	COG0760@1|root,COG0760@2|Bacteria,1MZDK@1224|Proteobacteria,1S9DN@1236|Gammaproteobacteria,1WW5A@135613|Chromatiales	135613|Chromatiales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
HKD1_k127_5770249_10	243233.MCA1644	6.103e-25	106.0	COG0271@1|root,COG0271@2|Bacteria,1QCDN@1224|Proteobacteria,1THS7@1236|Gammaproteobacteria,1XFIA@135618|Methylococcales	135618|Methylococcales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
HKD1_k127_5770249_21	1415780.JPOG01000001_gene1405	5.113e-07	51.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,1S8UC@1236|Gammaproteobacteria,1X7QC@135614|Xanthomonadales	135614|Xanthomonadales	S	BolA family transcriptional regulator	yciI	-	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD1_k127_5784013_4	251229.Chro_0395	2.721e-43	164.0	COG0058@1|root,COG0058@2|Bacteria,1FZUX@1117|Cyanobacteria,3VIE3@52604|Pleurocapsales	1117|Cyanobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_5784013_9	1337936.IJ00_11880	2.144e-05	51.0	2BEK3@1|root,328BH@2|Bacteria,1G79S@1117|Cyanobacteria,1HQ4J@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5784013_2	926550.CLDAP_05840	8.226e-53	212.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,2G903@200795|Chloroflexi	200795|Chloroflexi	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HKD1_k127_5784013_3	1454004.AW11_02539	3.18e-47	194.0	COG2815@1|root,COG2815@2|Bacteria,1RK04@1224|Proteobacteria,2VSGS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_5784013_8	1217720.ALOX01000157_gene2694	9.429e-07	53.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_5784013_7	1217720.ALOX01000157_gene2694	9.428e-16	78.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_5784013_1	1202962.KB907164_gene3969	6.514e-71	246.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,1S27C@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0000287,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0035870,GO:0036220,GO:0036222,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0046872,GO:0046983,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	iEC55989_1330.EC55989_3247,iECO111_1330.ECO111_3702,iECSE_1348.ECSE_3222,iECW_1372.ECW_m3212,iEKO11_1354.EKO11_0774,iEcE24377_1341.EcE24377A_3298,iWFL_1372.ECW_m3212	Ham1p_like
HKD1_k127_5784013_0	1211114.ALIP01000098_gene1855	1.875e-107	352.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,1RNTB@1236|Gammaproteobacteria,1X3QU@135614|Xanthomonadales	135614|Xanthomonadales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	GO:0006139,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016070,GO:0016072,GO:0016075,GO:0019439,GO:0034641,GO:0034655,GO:0034660,GO:0034661,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:1901360,GO:1901361,GO:1901575	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_5784013_5	713586.KB900536_gene1767	6.447e-37	145.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,1WX83@135613|Chromatiales	135613|Chromatiales	S	PFAM YicC-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_5817536_8	440512.C211_08374	4.468e-34	137.0	COG1589@1|root,COG1589@2|Bacteria,1N0T7@1224|Proteobacteria,1S9FJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly	ftsQ	GO:0000003,GO:0000278,GO:0000281,GO:0000910,GO:0000917,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0007049,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0016043,GO:0019954,GO:0022402,GO:0022414,GO:0022607,GO:0031224,GO:0031226,GO:0032153,GO:0032505,GO:0032506,GO:0042802,GO:0043093,GO:0044085,GO:0044425,GO:0044459,GO:0044464,GO:0051301,GO:0061640,GO:0071840,GO:0071944,GO:0090529,GO:1902410,GO:1903047	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD1_k127_5817536_2	396588.Tgr7_0774	2.598e-191	604.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,1RMXY@1236|Gammaproteobacteria,1WVUV@135613|Chromatiales	135613|Chromatiales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD1_k127_5817536_3	1249627.D779_1241	4.631e-162	518.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,1RPZS@1236|Gammaproteobacteria,1WXJ6@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_5817536_4	1123253.AUBD01000009_gene2265	2.303e-145	465.0	COG0774@1|root,COG0774@2|Bacteria,1MV6T@1224|Proteobacteria,1RQ72@1236|Gammaproteobacteria,1X38C@135614|Xanthomonadales	135614|Xanthomonadales	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HKD1_k127_5817536_1	472759.Nhal_3222	6.062e-233	735.0	COG0367@1|root,COG0367@2|Bacteria,1PRFK@1224|Proteobacteria,1RNBE@1236|Gammaproteobacteria,1WW7I@135613|Chromatiales	135613|Chromatiales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_5817536_5	1131553.JIBI01000005_gene2214	2.736e-105	352.0	COG5653@1|root,COG5653@2|Bacteria,1Q8ZK@1224|Proteobacteria,2VVZ2@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_5817536_7	472759.Nhal_3223	3.198e-41	160.0	COG0457@1|root,COG0457@2|Bacteria,1RIHH@1224|Proteobacteria,1S8T0@1236|Gammaproteobacteria,1WZT6@135613|Chromatiales	135613|Chromatiales	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11
HKD1_k127_5817536_9	1000565.METUNv1_02945	0.0006314	45.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2VU9G@28216|Betaproteobacteria,2KWFV@206389|Rhodocyclales	206389|Rhodocyclales	S	CoA-binding protein	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_5817536_0	519989.ECTPHS_06142	1.753e-273	848.0	COG0388@1|root,COG0388@2|Bacteria,1MX4I@1224|Proteobacteria,1RP30@1236|Gammaproteobacteria,1WW4Z@135613|Chromatiales	135613|Chromatiales	K	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,CN_hydrolase
HKD1_k127_5817536_6	1209072.ALBT01000033_gene1616	5.518e-94	312.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,1RMGV@1236|Gammaproteobacteria,1FGQB@10|Cellvibrio	1236|Gammaproteobacteria	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD1_k127_5839802_0	228410.NE1223	1.759e-119	390.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,2VPG3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_5839802_2	857087.Metme_4330	2.506e-34	140.0	28JAR@1|root,2Z95M@2|Bacteria,1RGE3@1224|Proteobacteria,1S5F4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	YfdX protein	yfdX	-	-	-	-	-	-	-	-	-	-	-	YfdX
HKD1_k127_5839802_1	1173024.KI912148_gene4266	7.161e-71	243.0	COG4803@1|root,COG4803@2|Bacteria,1G531@1117|Cyanobacteria,1JKWX@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
HKD1_k127_5840776_0	396588.Tgr7_0930	3.842e-194	612.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1WWGS@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the formation of L-homocysteine from O- succinyl-L-homoserine (OSHS) and hydrogen sulfide	metZ	-	-	ko:K10764	ko00270,ko00920,ko01100,map00270,map00920,map01100	-	R01288	RC00020,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_5840776_2	420324.KI911972_gene2998	7.048e-79	272.0	COG1912@1|root,COG1912@2|Bacteria,1MV99@1224|Proteobacteria,2TVNY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD1_k127_5840776_5	1499967.BAYZ01000135_gene73	0.0001178	46.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,GUN4,TIR_2
HKD1_k127_5840776_4	472759.Nhal_3277	4.721e-23	101.0	COG2960@1|root,COG2960@2|Bacteria,1N7AH@1224|Proteobacteria,1SCH1@1236|Gammaproteobacteria,1WYUC@135613|Chromatiales	135613|Chromatiales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HKD1_k127_5840776_3	713586.KB900536_gene1995	1.05e-55	199.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,1S67I@1236|Gammaproteobacteria,1WY86@135613|Chromatiales	135613|Chromatiales	K	Belongs to the P(II) protein family	-	-	-	ko:K04752	-	-	-	-	ko00000	-	-	-	P-II
HKD1_k127_5840776_1	765913.ThidrDRAFT_0180	1.68e-155	500.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,1RNKF@1236|Gammaproteobacteria,1WWT4@135613|Chromatiales	135613|Chromatiales	U	Ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_5842294_3	1123355.JHYO01000018_gene1661	2.72e-40	155.0	COG1633@1|root,COG1633@2|Bacteria,1RJFW@1224|Proteobacteria,2U6JY@28211|Alphaproteobacteria,36Z1C@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_5842294_0	314282.PCNPT3_01960	3.088e-254	803.0	COG0280@1|root,COG0857@1|root,COG0280@2|Bacteria,COG0857@2|Bacteria,1QTS5@1224|Proteobacteria,1RMJS@1236|Gammaproteobacteria,2QHD2@267894|Psychromonadaceae	1236|Gammaproteobacteria	C	belongs to the CobB CobQ family	pta	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006083,GO:0006084,GO:0006085,GO:0006091,GO:0006113,GO:0006139,GO:0006163,GO:0006164,GO:0006520,GO:0006566,GO:0006567,GO:0006629,GO:0006631,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008959,GO:0009056,GO:0009058,GO:0009063,GO:0009066,GO:0009068,GO:0009108,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0015980,GO:0016053,GO:0016054,GO:0016407,GO:0016740,GO:0016746,GO:0016747,GO:0016999,GO:0017000,GO:0017001,GO:0017144,GO:0018130,GO:0019413,GO:0019427,GO:0019438,GO:0019541,GO:0019637,GO:0019693,GO:0019752,GO:0032787,GO:0033865,GO:0033866,GO:0033875,GO:0034030,GO:0034032,GO:0034033,GO:0034641,GO:0034654,GO:0035383,GO:0035384,GO:0042737,GO:0043167,GO:0043169,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044282,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045733,GO:0046390,GO:0046394,GO:0046395,GO:0046459,GO:0046483,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0055086,GO:0055114,GO:0070689,GO:0071616,GO:0071704,GO:0072329,GO:0072330,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901565,GO:1901566,GO:1901575,GO:1901576,GO:1901605,GO:1901606	2.3.1.8	ko:K13788	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	iG2583_1286.G2583_2834,iYL1228.KPN_02688	AAA_26,DRTGG,PTA_PTB
HKD1_k127_5842294_4	1120936.KB907209_gene1838	1.042e-37	144.0	COG0599@1|root,COG0599@2|Bacteria	2|Bacteria	S	peroxiredoxin activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD1_k127_5842294_6	1173026.Glo7428_3900	0.0001473	54.0	COG1396@1|root,COG1396@2|Bacteria,1G398@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD1_k127_5842294_1	1297570.MESS4_830116	8.588e-120	398.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.72	ko:K00571	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_5842294_2	1415778.JQMM01000001_gene1301	7.688e-86	291.0	COG0651@1|root,COG0651@2|Bacteria,1MV6V@1224|Proteobacteria,1RQK5@1236|Gammaproteobacteria,1J4SZ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CP	Proton-conducting membrane transporter	-	-	-	ko:K05568	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M
HKD1_k127_5871598_3	748247.AZKH_2012	2.951e-44	169.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria,2KVI1@206389|Rhodocyclales	28216|Betaproteobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD1_k127_5871598_0	472759.Nhal_3420	1.119e-249	798.0	COG1674@1|root,COG3266@1|root,COG1674@2|Bacteria,COG3266@2|Bacteria,1MVPI@1224|Proteobacteria,1RM9A@1236|Gammaproteobacteria,1WWP6@135613|Chromatiales	135613|Chromatiales	D	DNA segregation ATPase FtsK SpoIIIE	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_5871598_4	1049564.TevJSym_av00470	1.148e-38	147.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,1RNWI@1236|Gammaproteobacteria,1J4M8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HKD1_k127_5871598_1	396588.Tgr7_2008	1.111e-82	282.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,1S1ZB@1236|Gammaproteobacteria,1WWJ2@135613|Chromatiales	135613|Chromatiales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD1_k127_5871598_2	1122951.ATUE01000006_gene1227	1.045e-77	269.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,1RYD7@1236|Gammaproteobacteria,3NJG0@468|Moraxellaceae	1236|Gammaproteobacteria	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	GO:0003674,GO:0003824,GO:0004057,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0016598,GO:0016740,GO:0016746,GO:0016755,GO:0019538,GO:0019941,GO:0030163,GO:0036211,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044464,GO:0051603,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD1_k127_5871598_5	572477.Alvin_2001	2.018e-28	121.0	COG0664@1|root,COG0664@2|Bacteria,1RC7W@1224|Proteobacteria,1S2ZD@1236|Gammaproteobacteria,1WY6E@135613|Chromatiales	135613|Chromatiales	T	PFAM Cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_5926746_6	765912.Thimo_1282	1.729e-07	57.0	2ED4J@1|root,338UZ@2|Bacteria,1N9XK@1224|Proteobacteria,1SEC5@1236|Gammaproteobacteria,1WZI3@135613|Chromatiales	135613|Chromatiales	S	Glycine-zipper domain	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HKD1_k127_5926746_4	686340.Metal_0663	6.837e-37	143.0	COG0797@1|root,COG0797@2|Bacteria,1MZ8S@1224|Proteobacteria,1RMCG@1236|Gammaproteobacteria,1XFJD@135618|Methylococcales	135618|Methylococcales	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	DPBB_1
HKD1_k127_5926746_7	1217718.ALOU01000016_gene3175	7.52e-06	52.0	2EQUD@1|root,33IE5@2|Bacteria,1NBUY@1224|Proteobacteria,2VU7T@28216|Betaproteobacteria,1K9ZD@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YXWGXW repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	YXWGXW
HKD1_k127_5926746_1	349124.Hhal_1044	1.127e-148	473.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,1RN7C@1236|Gammaproteobacteria,1WWX8@135613|Chromatiales	135613|Chromatiales	S	ATPase associated with various cellular activities, AAA_5	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
HKD1_k127_5926746_0	472759.Nhal_3438	0.0	1195.0	COG4548@1|root,COG4548@2|Bacteria,1MVBZ@1224|Proteobacteria,1RNN3@1236|Gammaproteobacteria,1X257@135613|Chromatiales	135613|Chromatiales	P	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD1_k127_5926746_2	335283.Neut_0177	7.908e-60	213.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,2VPG3@28216|Betaproteobacteria,3743S@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_5926746_5	228410.NE1302	3.111e-08	57.0	COG5464@1|root,COG5464@2|Bacteria,1MUSP@1224|Proteobacteria,2VPG3@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Putative transposase, YhgA-like	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_5926746_3	1499967.BAYZ01000170_gene5527	6.027e-56	218.0	COG1262@1|root,COG5635@1|root,COG1262@2|Bacteria,COG5635@2|Bacteria,2NR8B@2323|unclassified Bacteria	2|Bacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DUF4062,FGE-sulfatase,NACHT,TIR_2,TPR_12
HKD1_k127_5930624_4	511062.GU3_01055	9.087e-33	129.0	COG0494@1|root,COG0494@2|Bacteria,1RCX7@1224|Proteobacteria,1S3ZE@1236|Gammaproteobacteria,1Y4C1@135624|Aeromonadales	135624|Aeromonadales	L	Hydrolase	nudE	-	-	ko:K08312	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_5930624_2	572477.Alvin_0607	2.201e-85	287.0	COG1011@1|root,COG1011@2|Bacteria,1NH15@1224|Proteobacteria,1RP27@1236|Gammaproteobacteria,1WW6W@135613|Chromatiales	135613|Chromatiales	E	subfamily IA, variant 3	-	-	3.1.3.5	ko:K20881	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD,HAD_2,Hydrolase
HKD1_k127_5930624_1	472759.Nhal_2269	3.282e-86	291.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,1S23A@1236|Gammaproteobacteria,1WWYC@135613|Chromatiales	135613|Chromatiales	JM	PFAM Nucleotidyl transferase	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transferase
HKD1_k127_5930624_0	1049564.TevJSym_ao00360	8.219e-117	384.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,1RQ1Q@1236|Gammaproteobacteria,1J50Q@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	related to Ser Thr protein kinases	-	GO:0000166,GO:0000270,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006022,GO:0006040,GO:0006082,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009254,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030203,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901135,GO:1901265,GO:1901363,GO:1901564	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD1_k127_5930624_6	1125863.JAFN01000001_gene628	5.46e-06	48.0	COG3533@1|root,COG3533@2|Bacteria,1QZ4E@1224|Proteobacteria,43CFD@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Pec_lyase
HKD1_k127_5930624_3	518766.Rmar_2590	1.658e-42	157.0	COG3259@1|root,COG3259@2|Bacteria	2|Bacteria	C	Nickel-dependent hydrogenase	hoxH	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_5930624_5	187303.BN69_0845	1.865e-09	59.0	COG3259@1|root,COG3259@2|Bacteria,1QUQ7@1224|Proteobacteria,2TYKR@28211|Alphaproteobacteria,36Z9G@31993|Methylocystaceae	28211|Alphaproteobacteria	C	Nickel-dependent hydrogenase	-	-	1.12.1.2	ko:K00436	-	-	R00700	-	ko00000,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_5951675_1	436308.Nmar_1073	3.287e-11	77.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
HKD1_k127_5951675_0	43989.cce_1253	0.0	1014.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,3KKRW@43988|Cyanothece	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_5980185_2	1121472.AQWN01000009_gene442	4.384e-121	411.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,26762@186807|Peptococcaceae	186801|Clostridia	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,SNF2_N
HKD1_k127_5980185_3	56107.Cylst_0699	2.275e-115	376.0	COG4636@1|root,COG4636@2|Bacteria,1FZZW@1117|Cyanobacteria,1HKN7@1161|Nostocales	1117|Cyanobacteria	S	InterPro IPR008538	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_5980185_1	395494.Galf_0349	2.68e-225	709.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,2VI4G@28216|Betaproteobacteria,44V3P@713636|Nitrosomonadales	28216|Betaproteobacteria	H	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_5980185_0	349124.Hhal_1056	0.0	2098.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1WWAR@135613|Chromatiales	135613|Chromatiales	E	glutamate synthase	-	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_5988318_2	163908.KB235896_gene84	3.62e-18	84.0	COG3335@1|root,COG3335@2|Bacteria,1GGIG@1117|Cyanobacteria	1117|Cyanobacteria	L	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_5988318_3	1488328.JMCL01000194_gene4277	3.75e-13	74.0	COG5534@1|root,COG5534@2|Bacteria,1MXQ0@1224|Proteobacteria,1RPJI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Replication initiator protein	-	-	-	-	-	-	-	-	-	-	-	-	RPA
HKD1_k127_5988318_0	883080.HMPREF9697_02401	4.776e-242	761.0	COG1914@1|root,COG1914@2|Bacteria,1N0XH@1224|Proteobacteria,2VG5I@28211|Alphaproteobacteria,3JU6A@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Evidence Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_5988318_4	329726.AM1_4167	4.329e-06	51.0	COG3335@1|root,COG3335@2|Bacteria,1G6YC@1117|Cyanobacteria	1117|Cyanobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_5988318_1	1121378.KB899730_gene4057	3.652e-76	262.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,MipZ
HKD1_k127_5998854_0	1173024.KI912148_gene3732	5.227e-161	522.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_5998854_1	1123368.AUIS01000028_gene1325	1.042e-23	104.0	COG0845@1|root,COG0845@2|Bacteria,1PDUT@1224|Proteobacteria,1RQKD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_3,HlyD_D23,OEP
HKD1_k127_6031534_5	570967.JMLV01000003_gene2146	6.164e-24	104.0	COG4191@1|root,COG5002@1|root,COG4191@2|Bacteria,COG5002@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2JQ2C@204441|Rhodospirillales	204441|Rhodospirillales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HKD1_k127_6031534_3	396588.Tgr7_2474	1.044e-68	242.0	COG0121@1|root,COG0121@2|Bacteria,1PX9X@1224|Proteobacteria,1SBGN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Glutamine amidotransferase	egtC	-	-	-	-	-	-	-	-	-	-	-	GATase_4
HKD1_k127_6031534_0	1163617.SCD_n02100	0.0	1181.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VJIJ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_6031534_1	472759.Nhal_0357	3.451e-177	561.0	COG0334@1|root,COG0334@2|Bacteria,1MUMF@1224|Proteobacteria,1RPUZ@1236|Gammaproteobacteria,1WXUS@135613|Chromatiales	1236|Gammaproteobacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_6031534_4	472759.Nhal_2115	9.493e-56	199.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,1S7QZ@1236|Gammaproteobacteria,1WYRM@135613|Chromatiales	135613|Chromatiales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_6031534_2	1123401.JHYQ01000030_gene3077	1.185e-106	349.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,1RNWH@1236|Gammaproteobacteria,460MF@72273|Thiotrichales	72273|Thiotrichales	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6035696_1	472759.Nhal_0076	6.852e-138	445.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,1RPR7@1236|Gammaproteobacteria,1WWNM@135613|Chromatiales	135613|Chromatiales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_6035696_0	713586.KB900536_gene1665	2.785e-141	459.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,1RNXV@1236|Gammaproteobacteria,1WW7U@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_6035696_3	519989.ECTPHS_03759	2.214e-106	350.0	COG0134@1|root,COG0134@2|Bacteria,1MW5K@1224|Proteobacteria,1RNYH@1236|Gammaproteobacteria,1WW6P@135613|Chromatiales	135613|Chromatiales	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
HKD1_k127_6035696_6	768671.ThimaDRAFT_1427	3.572e-61	213.0	COG1765@1|root,COG1765@2|Bacteria,1RCZW@1224|Proteobacteria,1S3XF@1236|Gammaproteobacteria,1WY24@135613|Chromatiales	135613|Chromatiales	O	redox protein, regulator of disulfide bond formation	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD1_k127_6035696_2	1049564.TevJSym_ag00320	6.543e-136	436.0	COG1586@1|root,COG1586@2|Bacteria,1MXPT@1224|Proteobacteria,1RQSX@1236|Gammaproteobacteria,1J5KU@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	GO:0003674,GO:0003824,GO:0004014,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006576,GO:0006595,GO:0006596,GO:0006807,GO:0008150,GO:0008152,GO:0008216,GO:0008295,GO:0009058,GO:0009308,GO:0009309,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0034641,GO:0042401,GO:0044106,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0071704,GO:0097164,GO:1901564,GO:1901566,GO:1901576	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3412,iSDY_1059.SDY_0027	AdoMet_dc
HKD1_k127_6035696_4	572477.Alvin_0173	7.083e-78	265.0	COG2941@1|root,COG2941@2|Bacteria,1RAA1@1224|Proteobacteria,1RPMV@1236|Gammaproteobacteria,1WWM4@135613|Chromatiales	135613|Chromatiales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
HKD1_k127_6035696_5	243233.MCA0904	2.186e-69	238.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,1S280@1236|Gammaproteobacteria,1XF2I@135618|Methylococcales	135618|Methylococcales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_6035696_7	1120953.AUBH01000009_gene23	1.864e-58	205.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,1S3Q7@1236|Gammaproteobacteria,466SE@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Belongs to the universal ribosomal protein uS9 family	rpsI	GO:0000462,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016070,GO:0016072,GO:0019538,GO:0022613,GO:0022626,GO:0022627,GO:0030490,GO:0032991,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0097159,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_6035696_8	1487953.JMKF01000035_gene1207	2.551e-56	201.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core,Transglut_core3
HKD1_k127_6038287_1	29581.BW37_02753	2.097e-122	397.0	COG0411@1|root,COG0411@2|Bacteria,1MX51@1224|Proteobacteria,2VJN5@28216|Betaproteobacteria,473NP@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Branched-chain amino acid ATP-binding cassette transporter	drrA	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6038287_0	323848.Nmul_A0037	5.634e-179	585.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2VH2F@28216|Betaproteobacteria,371RW@32003|Nitrosomonadales	28216|Betaproteobacteria	P	TIGRFAM ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	ctpF	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_6050367_3	395493.BegalDRAFT_1494	5.902e-12	78.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,463PS@72273|Thiotrichales	72273|Thiotrichales	M	ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
HKD1_k127_6050367_2	1123368.AUIS01000032_gene1396	9.943e-190	602.0	COG0448@1|root,COG0448@2|Bacteria,1MVTC@1224|Proteobacteria,1RP04@1236|Gammaproteobacteria,2NBRQ@225057|Acidithiobacillales	1236|Gammaproteobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	-	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_6050367_0	1163617.SCD_n02434	0.0	1905.0	COG1640@1|root,COG3280@1|root,COG1640@2|Bacteria,COG3280@2|Bacteria,1QTVJ@1224|Proteobacteria,2WGPV@28216|Betaproteobacteria	28216|Betaproteobacteria	G	4-alpha-glucanotransferase	treY	-	2.4.1.25,5.4.99.15	ko:K00705,ko:K06044	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R01824,R05196,R09995	RC00049	ko00000,ko00001,ko00002,ko01000	-	GH13,GH77	-	Alpha-amylase,Glyco_hydro_77
HKD1_k127_6050367_1	1454004.AW11_02016	9.783e-217	682.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,2VJDX@28216|Betaproteobacteria	28216|Betaproteobacteria	G	trehalohydrolase	treZ	-	3.2.1.141	ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD1_k127_6052766_16	1122221.JHVI01000005_gene639	1.243e-06	58.0	COG1353@1|root,COG1353@2|Bacteria,1WJR2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	CRISPR-associated protein, Crm2 family	-	-	-	ko:K19076	-	-	-	-	ko00000,ko02048	-	-	-	DUF3692
HKD1_k127_6052766_7	448385.sce5682	1.156e-69	247.0	COG1336@1|root,COG1336@2|Bacteria,1RE1Y@1224|Proteobacteria,437UJ@68525|delta/epsilon subdivisions,2X344@28221|Deltaproteobacteria,2YVRD@29|Myxococcales	28221|Deltaproteobacteria	L	RAMP superfamily	-	-	-	ko:K09000	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
HKD1_k127_6052766_8	448385.sce5684	4.234e-60	218.0	COG1604@1|root,COG1604@2|Bacteria,1REU6@1224|Proteobacteria,43ACR@68525|delta/epsilon subdivisions,2X5SJ@28221|Deltaproteobacteria,2YVU4@29|Myxococcales	28221|Deltaproteobacteria	L	to be involved in DNA repair (RAMP superfamily)	-	-	-	ko:K19142	-	-	-	-	ko00000,ko02048	-	-	-	RAMPs
HKD1_k127_6052766_13	195253.Syn6312_2713	1.731e-21	102.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	proV	-	3.6.3.32	ko:K02000,ko:K05847	ko02010,map02010	M00208,M00209	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.12	-	iYO844.BSU33730	ABC_tran,CBS
HKD1_k127_6052766_5	426114.THI_3125	5.671e-99	328.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,1KNJ2@119065|unclassified Burkholderiales	28216|Betaproteobacteria	K	Evidence 2a Function of homologous gene experimentally demonstrated in an other organism	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6052766_2	426114.THI_3126	1.018e-123	411.0	COG0642@1|root,COG0642@2|Bacteria,1PA1G@1224|Proteobacteria,2VHX5@28216|Betaproteobacteria	28216|Betaproteobacteria	T	Histidine kinase	-	-	2.7.13.1	ko:K05962	-	-	-	-	ko00000,ko01000	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_6052766_11	1122164.JHWF01000003_gene2121	8.855e-30	124.0	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,1SA1R@1236|Gammaproteobacteria,1JG9B@118969|Legionellales	118969|Legionellales	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_6052766_9	1116472.MGMO_17c00090	7.161e-47	179.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,1S59S@1236|Gammaproteobacteria,1XFTG@135618|Methylococcales	135618|Methylococcales	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD1_k127_6052766_3	381666.H16_A1821	2.162e-104	347.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKD3@28216|Betaproteobacteria,1K0J2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF2063,DUF692
HKD1_k127_6052766_12	1137799.GZ78_12655	1.753e-22	99.0	COG5572@1|root,COG5572@2|Bacteria,1PCZI@1224|Proteobacteria,1SDT0@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
HKD1_k127_6052766_1	765912.Thimo_0610	1.406e-187	597.0	COG4248@1|root,COG4248@2|Bacteria	2|Bacteria	NU	protein with protein kinase and helix-hairpin-helix DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD1_k127_6052766_4	765912.Thimo_0609	1.986e-103	341.0	COG4245@1|root,COG4245@2|Bacteria	2|Bacteria	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_6052766_6	765912.Thimo_0608	1.949e-82	282.0	COG0631@1|root,COG0631@2|Bacteria,1NXF0@1224|Proteobacteria,1SQRX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Protein phosphatase 2C	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
HKD1_k127_6052766_0	472759.Nhal_1875	0.0	1168.0	COG1026@1|root,COG1026@2|Bacteria,1MVDJ@1224|Proteobacteria,1RYNI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Peptidase, M16	-	-	-	ko:K06972	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M16C_assoc,Peptidase_M16,Peptidase_M16_C
HKD1_k127_6073384_6	118163.Ple7327_1917	1.637e-09	60.0	COG1305@1|root,COG1305@2|Bacteria,1G09A@1117|Cyanobacteria,3VJTN@52604|Pleurocapsales	1117|Cyanobacteria	E	PFAM Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_6073384_2	530564.Psta_3392	2.417e-74	258.0	COG1305@1|root,COG1305@2|Bacteria,2IY1Q@203682|Planctomycetes	203682|Planctomycetes	E	Transglutaminase/protease-like homologues	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_6073384_5	118163.Ple7327_1917	7.169e-16	78.0	COG1305@1|root,COG1305@2|Bacteria,1G09A@1117|Cyanobacteria,3VJTN@52604|Pleurocapsales	1117|Cyanobacteria	E	PFAM Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,Transglut_core
HKD1_k127_6073384_0	697282.Mettu_0224	0.0	1109.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,1RMYC@1236|Gammaproteobacteria,1XEIG@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.6	ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_6073384_1	1121396.KB893086_gene303	2.822e-78	269.0	COG3293@1|root,COG3293@2|Bacteria,1P5HD@1224|Proteobacteria,42TZG@68525|delta/epsilon subdivisions,2WQT4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	manually curated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD1_k127_6073384_4	686340.Metal_1563	1.095e-27	114.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
HKD1_k127_6073384_3	686340.Metal_1563	4.871e-45	168.0	COG3039@1|root,COG3039@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_3
HKD1_k127_6100361_2	1122603.ATVI01000009_gene2647	0.0	1118.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,1RN8P@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_6100361_1	269799.Gmet_2767	0.0	1270.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,42Y60@68525|delta/epsilon subdivisions,2WUR1@28221|Deltaproteobacteria,43T95@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	Phosphorylase
HKD1_k127_6100361_0	1123392.AQWL01000002_gene1978	0.0	1344.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2VHFI@28216|Betaproteobacteria,1KSKV@119069|Hydrogenophilales	119069|Hydrogenophilales	V	MMPL family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_6100361_3	395493.BegalDRAFT_2350	6.199e-47	173.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,460R1@72273|Thiotrichales	72273|Thiotrichales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD1_k127_6136337_0	765912.Thimo_0760	4.366e-131	424.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,1RNNY@1236|Gammaproteobacteria,1WVZH@135613|Chromatiales	135613|Chromatiales	F	SAICAR synthetase	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD1_k127_6136337_3	1298593.TOL_0331	8.183e-06	49.0	COG3235@1|root,COG3235@2|Bacteria,1RDHR@1224|Proteobacteria,1S3KS@1236|Gammaproteobacteria,1XJH0@135619|Oceanospirillales	135619|Oceanospirillales	S	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
HKD1_k127_6136337_1	349521.HCH_00578	3.443e-59	214.0	COG1076@1|root,COG1076@2|Bacteria,1N270@1224|Proteobacteria,1RP0P@1236|Gammaproteobacteria,1XJA6@135619|Oceanospirillales	135619|Oceanospirillales	O	Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host	djlA	-	-	ko:K05801	-	-	-	-	ko00000,ko03110	-	-	-	DnaJ,TerB
HKD1_k127_6136337_2	1121033.AUCF01000005_gene5240	3.094e-49	182.0	COG4953@1|root,COG4953@2|Bacteria,1MUA9@1224|Proteobacteria,2TR2R@28211|Alphaproteobacteria,2JQSN@204441|Rhodospirillales	204441|Rhodospirillales	M	Penicillin-Binding Protein C-terminus Family	-	-	2.4.1.129	ko:K05367	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	BiPBP_C,Transgly,Transpeptidase
HKD1_k127_6151560_5	1049564.TevJSym_ai00310	1.94e-30	121.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,1RN90@1236|Gammaproteobacteria,1J5E9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02464,ko:K02654	ko03070,map03070	M00331	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD1_k127_6151560_4	713586.KB900536_gene1359	7.007e-53	193.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,1S3NR@1236|Gammaproteobacteria,1WY99@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD1_k127_6151560_3	472759.Nhal_3851	4.698e-67	237.0	COG4582@1|root,COG4582@2|Bacteria,1MW69@1224|Proteobacteria,1RNPD@1236|Gammaproteobacteria,1WWH6@135613|Chromatiales	135613|Chromatiales	D	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity	zapD	-	-	ko:K18778	-	-	-	-	ko00000,ko03036	-	-	-	ZapD
HKD1_k127_6151560_0	1454004.AW11_02136	0.0	1721.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2VK83@28216|Betaproteobacteria,1KQXK@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferase family 21	-	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Cellulose_synt,Glyco_tranf_2_3,Glycos_transf_2
HKD1_k127_6151560_1	861299.J421_0912	3.309e-215	690.0	COG3664@1|root,COG3664@2|Bacteria	2|Bacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
HKD1_k127_6151560_2	301.JNHE01000006_gene1150	1.899e-83	278.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,1RP0W@1236|Gammaproteobacteria,1YE2Q@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	GO:0003674,GO:0003824,GO:0004015,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iUTI89_1310.UTI89_C0772,iZ_1308.Z0993	Aminotran_3
HKD1_k127_6151690_2	765911.Thivi_2456	5.162e-29	126.0	COG4223@1|root,COG4223@2|Bacteria,1NDYH@1224|Proteobacteria,1SKYF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	DZ	transferase activity, transferring acyl groups other than amino-acyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6151690_0	765911.Thivi_2457	7.839e-72	249.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,1RS0G@1236|Gammaproteobacteria,1WZSK@135613|Chromatiales	135613|Chromatiales	KT	PFAM PspA IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD1_k127_6151690_3	1249627.D779_0256	1.554e-17	83.0	COG5450@1|root,COG5450@2|Bacteria,1N76R@1224|Proteobacteria,1SD4N@1236|Gammaproteobacteria,1WZP4@135613|Chromatiales	135613|Chromatiales	K	Bacterial antitoxin of type II TA system, VapB	-	-	-	-	-	-	-	-	-	-	-	-	VapB_antitoxin
HKD1_k127_6151690_1	395493.BegalDRAFT_1144	1.774e-51	185.0	COG1487@1|root,COG1487@2|Bacteria,1RHIX@1224|Proteobacteria,1S6AM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_6151690_4	1121396.KB893078_gene788	1.112e-10	64.0	2946W@1|root,2ZRMA@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6151690_5	397291.C804_00483	5.149e-10	61.0	2946W@1|root,2ZRMA@2|Bacteria	2|Bacteria	S	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6180721_5	1283300.ATXB01000001_gene215	3.732e-63	218.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,1RMVK@1236|Gammaproteobacteria,1XEIT@135618|Methylococcales	135618|Methylococcales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_6180721_2	1121346.KB899835_gene922	7.013e-133	427.0	COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,4H9QS@91061|Bacilli,26T1B@186822|Paenibacillaceae	91061|Bacilli	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD1_k127_6180721_3	1260251.SPISAL_01070	8.167e-112	368.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,1RMFR@1236|Gammaproteobacteria,1WWRE@135613|Chromatiales	135613|Chromatiales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD1_k127_6180721_1	105559.Nwat_1733	5.42e-134	436.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,1RNIN@1236|Gammaproteobacteria,1WW5G@135613|Chromatiales	135613|Chromatiales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_6180721_0	765912.Thimo_3623	3.409e-171	550.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1WVY3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the peptidase M16 family	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_6180721_4	395493.BegalDRAFT_2422	7.681e-98	329.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,45ZZU@72273|Thiotrichales	72273|Thiotrichales	S	Peptidase M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_6202491_1	1283300.ATXB01000001_gene1240	1.71e-186	586.0	COG1543@1|root,COG1543@2|Bacteria,1R5SN@1224|Proteobacteria,1S1IY@1236|Gammaproteobacteria,1XEJV@135618|Methylococcales	135618|Methylococcales	G	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57
HKD1_k127_6202491_0	1479237.JMLY01000001_gene49	5.13e-235	734.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,1RMWS@1236|Gammaproteobacteria,4646Q@72275|Alteromonadaceae	1236|Gammaproteobacteria	F	COG0138 AICAR transformylase IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)	purH	GO:0003674,GO:0003824,GO:0004643,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016742,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iEcHS_1320.EcHS_A4240,iPC815.YPO3728	AICARFT_IMPCHas,MGS
HKD1_k127_6203442_0	1123354.AUDR01000013_gene538	2.251e-135	438.0	COG0859@1|root,COG0859@2|Bacteria,1MXA2@1224|Proteobacteria,2VHHX@28216|Betaproteobacteria,1KRUC@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD1_k127_6203442_2	95619.PM1_0201295	6.732e-109	364.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,1RPMN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	lipopolysaccharide heptosyltransferase I	rfaC	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008713,GO:0008920,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044424,GO:0044444,GO:0044464,GO:0046401,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	iB21_1397.B21_03429,iECBD_1354.ECBD_0105,iECB_1328.ECB_03478,iECD_1391.ECD_03478,iECNA114_1301.ECNA114_3774,iECSF_1327.ECSF_3456,iSF_1195.SF3661,iS_1188.S4107	Glyco_transf_9
HKD1_k127_6203442_1	743720.Psefu_4189	1.586e-116	387.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,1RQE3@1236|Gammaproteobacteria,1YVDK@136845|Pseudomonas putida group	1236|Gammaproteobacteria	M	glycosyl transferase group 1	rfaG	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0006629,GO:0008150,GO:0008152,GO:0008194,GO:0008610,GO:0008653,GO:0008919,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0035251,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0046401,GO:0046527,GO:0071704,GO:1901135,GO:1901137,GO:1901576,GO:1903509	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	iSDY_1059.SDY_4061	Glyco_transf_4,Glycos_transf_1
HKD1_k127_6203442_3	1123367.C666_04355	6.981e-81	278.0	COG0515@1|root,COG0515@2|Bacteria,1MXX9@1224|Proteobacteria,2VHSR@28216|Betaproteobacteria,2KVD9@206389|Rhodocyclales	206389|Rhodocyclales	KLT	Catalyzes the phosphorylation of heptose(I) of the outer membrane lipopolysaccharide core	-	-	-	ko:K02848	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Kdo
HKD1_k127_6203442_4	1122216.AUHW01000001_gene767	2.091e-21	102.0	COG2076@1|root,COG2076@2|Bacteria,1VF8J@1239|Firmicutes,4H695@909932|Negativicutes	909932|Negativicutes	P	Small Multidrug Resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_6203442_5	1122139.KB907875_gene2547	6.023e-09	57.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1XHCB@135619|Oceanospirillales	135619|Oceanospirillales	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_6203497_0	713586.KB900536_gene1203	1.583e-144	469.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_6203497_6	292415.Tbd_0610	4.035e-08	61.0	COG1422@1|root,COG1422@2|Bacteria,1RJ93@1224|Proteobacteria,2VSU6@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1090)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6203497_5	756272.Plabr_0812	1.061e-08	59.0	COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,2IX74@203682|Planctomycetes	203682|Planctomycetes	P	COG0025 NhaP-type Na H and K H	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_6203497_4	1121930.AQXG01000006_gene797	8.08e-13	74.0	COG0025@1|root,COG0025@2|Bacteria,4PKJ5@976|Bacteroidetes	976|Bacteroidetes	P	NhaP-type Na H and K H	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_6203497_3	756272.Plabr_0812	2.768e-13	75.0	COG0025@1|root,COG0569@1|root,COG0025@2|Bacteria,COG0569@2|Bacteria,2IX74@203682|Planctomycetes	203682|Planctomycetes	P	COG0025 NhaP-type Na H and K H	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_6203497_2	105559.Nwat_1493	7.291e-97	332.0	COG1295@1|root,COG1959@1|root,COG1295@2|Bacteria,COG1959@2|Bacteria,1QICW@1224|Proteobacteria,1RMKI@1236|Gammaproteobacteria,1WWKW@135613|Chromatiales	135613|Chromatiales	K	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Rrf2,Virul_fac_BrkB
HKD1_k127_6203497_1	713587.THITH_16390	1.554e-124	420.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,1RMS8@1236|Gammaproteobacteria,1WX5E@135613|Chromatiales	135613|Chromatiales	M	PFAM Lytic	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,SLT_L
HKD1_k127_6237649_2	322710.Avin_28180	6.853e-61	211.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,1RNAQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004828,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006434,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009059,GO:0009069,GO:0009070,GO:0009987,GO:0010467,GO:0016053,GO:0016070,GO:0016259,GO:0016260,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0042802,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046872,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iSDY_1059.SDY_2368	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_6237649_3	449447.MAE_01490	1.428e-22	98.0	COG3335@1|root,COG3335@2|Bacteria	2|Bacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_6237649_0	748247.AZKH_1669	6.459e-110	360.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VJ7G@28216|Betaproteobacteria	28216|Betaproteobacteria	V	abc transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_6237649_1	489825.LYNGBM3L_63180	3.796e-85	289.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria,1H9BF@1150|Oscillatoriales	1117|Cyanobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_6258002_1	395495.Lcho_3595	1.851e-80	271.0	COG4177@1|root,COG4177@2|Bacteria,1MWP3@1224|Proteobacteria,2VJA3@28216|Betaproteobacteria,1KJ4J@119065|unclassified Burkholderiales	28216|Betaproteobacteria	E	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6258002_2	485913.Krac_10225	4.369e-71	251.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6258002_3	1144319.PMI16_00805	1.556e-53	194.0	COG1595@1|root,COG1595@2|Bacteria,1PT8E@1224|Proteobacteria,2W1XX@28216|Betaproteobacteria,476Q7@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6258002_0	1005048.CFU_1840	9.883e-119	385.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,475EI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_6267833_3	272134.KB731324_gene4312	3.767e-09	59.0	COG0724@1|root,COG0724@2|Bacteria,1G6TA@1117|Cyanobacteria,1HBXH@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_6267833_2	1208323.B30_13714	3.803e-12	73.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	transcriptional regulator	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD1_k127_6267833_1	316274.Haur_4784	2.129e-23	111.0	COG0412@1|root,COG0412@2|Bacteria,2G8GH@200795|Chloroflexi	200795|Chloroflexi	Q	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6267833_0	338963.Pcar_0349	4.487e-106	353.0	COG1250@1|root,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,42M6J@68525|delta/epsilon subdivisions,2WJZQ@28221|Deltaproteobacteria,43USZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2269	3HCDH,3HCDH_N
HKD1_k127_6276075_0	449447.MAE_33340	3.161e-143	462.0	COG3335@1|root,COG3415@1|root,COG3335@2|Bacteria,COG3415@2|Bacteria,1G3YK@1117|Cyanobacteria	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3,HTH_23
HKD1_k127_6276075_3	1283300.ATXB01000001_gene2414	9.997e-35	138.0	COG3385@1|root,COG3385@2|Bacteria,1PHKQ@1224|Proteobacteria,1SIFZ@1236|Gammaproteobacteria	1224|Proteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD1_k127_6276075_2	1163617.SCD_n02953	5.184e-76	279.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,2VIK1@28216|Betaproteobacteria	28216|Betaproteobacteria	U	SMART AAA ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,Epimerase_2
HKD1_k127_6276075_4	1123060.JONP01000007_gene5057	3.27e-17	96.0	COG0790@1|root,COG0790@2|Bacteria,1NKWN@1224|Proteobacteria,2UJNX@28211|Alphaproteobacteria,2JY5U@204441|Rhodospirillales	204441|Rhodospirillales	S	COG0790 FOG TPR repeat, SEL1 subfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6276075_1	1380394.JADL01000019_gene1928	7.45e-104	346.0	COG2358@1|root,COG2358@2|Bacteria,1MWSG@1224|Proteobacteria,2TSVY@28211|Alphaproteobacteria,2JVWE@204441|Rhodospirillales	204441|Rhodospirillales	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD1_k127_6298025_4	765912.Thimo_0674	6.175e-128	417.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,1RNB2@1236|Gammaproteobacteria,1WVZ4@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_6298025_3	1434325.AZQN01000001_gene316	8.966e-147	468.0	COG0447@1|root,COG0447@2|Bacteria,4NDXT@976|Bacteroidetes,47JYS@768503|Cytophagia	976|Bacteroidetes	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_6298025_13	768671.ThimaDRAFT_4512	3.528e-06	56.0	2DN7H@1|root,32VYK@2|Bacteria,1PS54@1224|Proteobacteria,1SJ2E@1236|Gammaproteobacteria,1X1JX@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6298025_11	1000565.METUNv1_00887	5.97e-20	93.0	2CHAX@1|root,32ZC9@2|Bacteria,1N6X2@1224|Proteobacteria,2VW2I@28216|Betaproteobacteria,2KX73@206389|Rhodocyclales	206389|Rhodocyclales	S	Protein of unknown function (DUF3301)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3301
HKD1_k127_6298025_7	1278309.KB907104_gene876	3.932e-47	177.0	COG0824@1|root,COG0824@2|Bacteria,1RF7Q@1224|Proteobacteria,1S7PD@1236|Gammaproteobacteria,1XS7Q@135619|Oceanospirillales	135619|Oceanospirillales	S	Thioesterase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT_2
HKD1_k127_6298025_9	1283300.ATXB01000001_gene738	2.679e-28	123.0	COG1833@1|root,COG1833@2|Bacteria,1N8Y1@1224|Proteobacteria,1SDIB@1236|Gammaproteobacteria,1XGWK@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function DUF123	-	-	-	-	-	-	-	-	-	-	-	-	DUF123
HKD1_k127_6298025_0	765912.Thimo_3518	0.0	1107.0	COG2766@1|root,COG2766@2|Bacteria,1MVW7@1224|Proteobacteria,1RNFJ@1236|Gammaproteobacteria,1WWXB@135613|Chromatiales	135613|Chromatiales	T	PFAM PrkA AAA	-	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HKD1_k127_6298025_2	631362.Thi970DRAFT_01219	6.335e-182	577.0	COG2718@1|root,COG2718@2|Bacteria,1MWQM@1224|Proteobacteria,1RQWC@1236|Gammaproteobacteria,1WWH8@135613|Chromatiales	135613|Chromatiales	S	Belongs to the UPF0229 family	-	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HKD1_k127_6298025_1	768671.ThimaDRAFT_2174	3.745e-263	817.0	COG2719@1|root,COG2719@2|Bacteria,1MW6U@1224|Proteobacteria,1RPU2@1236|Gammaproteobacteria,1WWU8@135613|Chromatiales	135613|Chromatiales	S	SpoVR family	-	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD1_k127_6298025_8	1027273.GZ77_10225	5.962e-33	134.0	COG0517@1|root,COG0517@2|Bacteria,1N8E9@1224|Proteobacteria,1SC9B@1236|Gammaproteobacteria,1XMRX@135619|Oceanospirillales	135619|Oceanospirillales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_6298025_5	243233.MCA1690	5.517e-70	248.0	COG3770@1|root,COG3770@2|Bacteria,1MU9I@1224|Proteobacteria,1RMJK@1236|Gammaproteobacteria,1XE64@135618|Methylococcales	135618|Methylococcales	M	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus	-	-	-	ko:K07261	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M74
HKD1_k127_6298025_6	768671.ThimaDRAFT_1223	2.03e-61	215.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,1S5WI@1236|Gammaproteobacteria,1WYPS@135613|Chromatiales	135613|Chromatiales	O	Belongs to the MsrB Met sulfoxide reductase family	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD1_k127_6298025_12	929712.KI912613_gene387	1.29e-09	59.0	COG1028@1|root,COG1028@2|Bacteria,2GIYQ@201174|Actinobacteria	201174|Actinobacteria	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6298025_10	247633.GP2143_01875	4.903e-24	106.0	2E80T@1|root,332F0@2|Bacteria,1N7RY@1224|Proteobacteria,1SCE8@1236|Gammaproteobacteria,1J6W5@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4389
HKD1_k127_6298025_14	1283300.ATXB01000002_gene2734	0.0001086	45.0	COG2433@1|root,COG2433@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,zf-IS66
HKD1_k127_6300647_1	754477.Q7C_2236	1.663e-109	362.0	COG2334@1|root,COG2334@2|Bacteria,1MUKJ@1224|Proteobacteria,1RPR6@1236|Gammaproteobacteria,460A9@72273|Thiotrichales	72273|Thiotrichales	F	Belongs to the pseudomonas-type ThrB family	thrB	-	2.7.1.39	ko:K02204	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	APH,TusA
HKD1_k127_6300647_0	187272.Mlg_0248	1.833e-161	512.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,1RMEX@1236|Gammaproteobacteria,1WWPK@135613|Chromatiales	135613|Chromatiales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6300647_2	1207076.ALAT01000089_gene1018	1.698e-103	338.0	COG0450@1|root,COG0450@2|Bacteria,1MWPY@1224|Proteobacteria,1RN4S@1236|Gammaproteobacteria,1Z1YI@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	O	Alkyl hydroperoxide reductase subunit C	tsaA	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_6300647_4	545264.KB898744_gene2003	1.641e-43	165.0	COG0526@1|root,COG0526@2|Bacteria,1RJUZ@1224|Proteobacteria,1S6Y0@1236|Gammaproteobacteria,1WYNQ@135613|Chromatiales	135613|Chromatiales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_6300647_3	713586.KB900536_gene1599	3.585e-97	322.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,1RN41@1236|Gammaproteobacteria,1WVZG@135613|Chromatiales	135613|Chromatiales	T	phosphate regulon transcriptional regulatory protein PhoB	-	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6333966_0	338966.Ppro_1649	1.037e-106	355.0	COG3064@1|root,COG3666@1|root,COG3064@2|Bacteria,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_6333966_7	324925.Ppha_0340	1.901e-07	54.0	COG3666@1|root,COG3666@2|Bacteria	2|Bacteria	-	-	tnp15	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_6333966_6	697282.Mettu_4371	2.777e-28	115.0	COG3666@1|root,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,1RQTW@1236|Gammaproteobacteria,1XGCS@135618|Methylococcales	1236|Gammaproteobacteria	L	PFAM Transposase, IS4-like	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_6333966_4	765913.ThidrDRAFT_1130	1.196e-42	166.0	COG0551@1|root,COG0551@2|Bacteria,1PZFI@1224|Proteobacteria,1RQ64@1236|Gammaproteobacteria,1WXVE@135613|Chromatiales	135613|Chromatiales	L	NERD domain protein	-	-	-	-	-	-	-	-	-	-	-	-	NERD,zf-C4_Topoisom
HKD1_k127_6333966_5	322710.Avin_39810	2.051e-35	137.0	COG4453@1|root,COG4453@2|Bacteria,1N7K8@1224|Proteobacteria,1SC3I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1778)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1778
HKD1_k127_6333966_2	340.xcc-b100_1083	2.263e-65	227.0	COG0454@1|root,COG0454@2|Bacteria,1RHV9@1224|Proteobacteria,1S76Y@1236|Gammaproteobacteria,1X7H6@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
HKD1_k127_6333966_3	323261.Noc_0496	1.784e-62	216.0	COG0346@1|root,COG0346@2|Bacteria,1RI3Q@1224|Proteobacteria,1S6F6@1236|Gammaproteobacteria,1X126@135613|Chromatiales	135613|Chromatiales	C	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_6333966_1	658187.LDG_7519	2.88e-84	284.0	COG4974@1|root,COG4974@2|Bacteria,1R6F9@1224|Proteobacteria,1S0TK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Type 1 fimbriae regulatory protein	fimB	-	-	ko:K07357	-	-	-	-	ko00000	-	-	-	Phage_integrase
HKD1_k127_6379587_1	338969.Rfer_0828	5.298e-77	263.0	COG1335@1|root,COG1335@2|Bacteria,1MUGW@1224|Proteobacteria,2VIMK@28216|Betaproteobacteria,4ADA4@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Isochorismatase family	pncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HKD1_k127_6379587_0	1123393.KB891326_gene76	6.829e-183	581.0	COG1488@1|root,COG1488@2|Bacteria,1PNWY@1224|Proteobacteria,2W9DN@28216|Betaproteobacteria,1KS4Z@119069|Hydrogenophilales	119069|Hydrogenophilales	H	Nicotinate phosphoribosyltransferase (NAPRTase) family	-	-	-	-	-	-	-	-	-	-	-	-	NAPRTase
HKD1_k127_6379587_3	768671.ThimaDRAFT_2220	2.692e-29	121.0	COG2105@1|root,COG2105@2|Bacteria,1RH3X@1224|Proteobacteria,1S68T@1236|Gammaproteobacteria,1WYAJ@135613|Chromatiales	135613|Chromatiales	S	PFAM AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
HKD1_k127_6379587_2	1000565.METUNv1_03788	1.314e-70	249.0	COG0741@1|root,COG0790@1|root,COG0741@2|Bacteria,COG0790@2|Bacteria,1MZ4X@1224|Proteobacteria,2VM6E@28216|Betaproteobacteria,2KV7Z@206389|Rhodocyclales	206389|Rhodocyclales	M	Lytic transglycosylase	-	-	-	-	-	-	-	-	-	-	-	-	SLT,Sel1
HKD1_k127_6379587_4	1056512.D515_01793	7.479e-17	79.0	COG1126@1|root,COG1126@2|Bacteria,1MU9Q@1224|Proteobacteria,1RMX1@1236|Gammaproteobacteria,1XTEU@135623|Vibrionales	135623|Vibrionales	E	COG1126 ABC-type polar amino acid transport system, ATPase component	aapP	-	3.6.3.21	ko:K02028,ko:K09972	ko02010,map02010	M00232,M00236	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.17,3.A.1.3.18,3.A.1.3.7,3.A.1.3.8	-	-	ABC_tran
HKD1_k127_6398249_7	870187.Thini_3157	3.506e-44	162.0	COG1561@1|root,COG1561@2|Bacteria,1MWRA@1224|Proteobacteria,1RMAB@1236|Gammaproteobacteria,460H3@72273|Thiotrichales	72273|Thiotrichales	S	PFAM YicC-like family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_6398249_4	42565.FP66_02335	1.238e-67	237.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,1RN09@1236|Gammaproteobacteria,1XJ5P@135619|Oceanospirillales	135619|Oceanospirillales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD1_k127_6398249_10	1335757.SPICUR_01535	1.226e-21	97.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,1SCSR@1236|Gammaproteobacteria,1WYPW@135613|Chromatiales	135613|Chromatiales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_6398249_0	519989.ECTPHS_04239	6.921e-280	879.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,1RN3H@1236|Gammaproteobacteria,1WWZ3@135613|Chromatiales	135613|Chromatiales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_6398249_5	396588.Tgr7_3184	4.192e-56	198.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1WY7E@135613|Chromatiales	135613|Chromatiales	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_6398249_8	1125973.JNLC01000012_gene978	5.509e-28	123.0	COG3544@1|root,COG3544@2|Bacteria,1N0KY@1224|Proteobacteria,2UC2H@28211|Alphaproteobacteria,3K0TX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
HKD1_k127_6398249_3	395493.BegalDRAFT_0673	5.879e-77	266.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,1S0KH@1236|Gammaproteobacteria,460ME@72273|Thiotrichales	72273|Thiotrichales	O	O-methyltransferase	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_6398249_13	948565.AFFP02000003_gene2004	1.038e-09	60.0	COG0715@1|root,COG0715@2|Bacteria,1MVRA@1224|Proteobacteria,1RNG0@1236|Gammaproteobacteria,1Y7V9@135625|Pasteurellales	135625|Pasteurellales	P	Thiamine biosynthesis protein	Z012_04120	-	-	ko:K15598	ko02010,map02010	M00442	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.17.3,3.A.1.17.6	-	-	NMT1
HKD1_k127_6398249_9	1173025.GEI7407_3674	8.355e-28	115.0	COG0819@1|root,COG0819@2|Bacteria,1G375@1117|Cyanobacteria,1H8Y4@1150|Oscillatoriales	1117|Cyanobacteria	K	PFAM TENA THI-4 PQQC family	-	-	3.5.99.2	ko:K03707	ko00730,ko01100,map00730,map01100	-	R02133,R09993	RC00224,RC00652,RC02832	ko00000,ko00001,ko01000,ko03000	-	-	-	TENA_THI-4
HKD1_k127_6398249_1	314278.NB231_01823	4.356e-103	342.0	COG0175@1|root,COG0175@2|Bacteria,1MXUR@1224|Proteobacteria,1RNC5@1236|Gammaproteobacteria,1WX1T@135613|Chromatiales	135613|Chromatiales	EH	Belongs to the PAPS reductase family. CysH subfamily	cysH	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD1_k127_6398249_11	266117.Rxyl_1230	5.009e-17	93.0	COG0671@1|root,COG0671@2|Bacteria	2|Bacteria	I	phosphatidate phosphatase activity	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_6398249_6	697282.Mettu_2281	4.945e-55	194.0	COG0730@1|root,COG0730@2|Bacteria,1QDQW@1224|Proteobacteria,1SA4B@1236|Gammaproteobacteria,1XGG8@135618|Methylococcales	135618|Methylococcales	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_6398249_2	1097668.BYI23_B004170	6.42e-103	339.0	COG2875@1|root,COG2875@2|Bacteria,1MVYY@1224|Proteobacteria,2VHWE@28216|Betaproteobacteria,1K113@119060|Burkholderiaceae	28216|Betaproteobacteria	H	Precorrin-4 C(11)-methyltransferase	cobM	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_6398249_12	1207076.ALAT01000099_gene2357	1.585e-16	80.0	COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,1RPJG@1236|Gammaproteobacteria,1Z45K@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobL	-	2.1.1.132,2.1.1.196	ko:K00595,ko:K02191	ko00860,ko01100,map00860,map01100	-	R05149,R05813,R07774	RC00003,RC01279,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	MTS,Methyltransf_31,PCMT,TP_methylase
HKD1_k127_6402535_18	1198232.CYCME_0758	2.958e-26	110.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,1S62N@1236|Gammaproteobacteria,460WT@72273|Thiotrichales	72273|Thiotrichales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD1_k127_6402535_5	472759.Nhal_2397	1.016e-90	302.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,1RPE1@1236|Gammaproteobacteria,1WW32@135613|Chromatiales	135613|Chromatiales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD1_k127_6402535_14	519989.ECTPHS_13113	2.229e-43	160.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,1S973@1236|Gammaproteobacteria,1WYKG@135613|Chromatiales	135613|Chromatiales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD1_k127_6402535_10	395493.BegalDRAFT_2614	3.666e-64	221.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,1S3Z3@1236|Gammaproteobacteria,460HS@72273|Thiotrichales	72273|Thiotrichales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD1_k127_6402535_15	1207076.ALAT01000168_gene3745	6.257e-34	131.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,1S8SS@1236|Gammaproteobacteria,1Z37V@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042221,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046677,GO:0050896,GO:0065003,GO:0070181,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD1_k127_6402535_19	1121943.KB900007_gene1958	1.213e-15	79.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,1SCBN@1236|Gammaproteobacteria,1XM6U@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD1_k127_6402535_9	246195.DNO_1268	4.742e-68	233.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,1S201@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	GO:0000027,GO:0000049,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD1_k127_6402535_3	1049564.TevJSym_aa00080	5.59e-110	359.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,1RN0P@1236|Gammaproteobacteria,1J4GK@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	GO:0000028,GO:0002181,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD1_k127_6402535_13	396588.Tgr7_2319	6.46e-44	163.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,1S5XT@1236|Gammaproteobacteria,1WYH7@135613|Chromatiales	135613|Chromatiales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD1_k127_6402535_12	765912.Thimo_2856	3.358e-45	164.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,1S5VT@1236|Gammaproteobacteria,1WYHJ@135613|Chromatiales	135613|Chromatiales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD1_k127_6402535_2	1168065.DOK_05915	8.291e-144	459.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,1RMGR@1236|Gammaproteobacteria,1J4FI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	GO:0000027,GO:0002181,GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008270,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046872,GO:0046914,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_6402535_16	1121004.ATVC01000003_gene525	5.821e-32	127.0	COG0089@1|root,COG0089@2|Bacteria,1MZXX@1224|Proteobacteria,2VU1C@28216|Betaproteobacteria,2KRGC@206351|Neisseriales	206351|Neisseriales	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD1_k127_6402535_6	1454202.PPBDW_80319___1	3.984e-74	255.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,1RNNK@1236|Gammaproteobacteria,1XSUF@135623|Vibrionales	135623|Vibrionales	J	Forms part of the polypeptide exit tunnel	rplD	GO:0003674,GO:0003676,GO:0003723,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD1_k127_6402535_4	550540.Fbal_0269	1.589e-97	322.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,1RMK9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	GO:0000027,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022625,GO:0022626,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042273,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_6402535_11	1049564.TevJSym_aa00010	4.821e-56	198.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,1S3QX@1236|Gammaproteobacteria,1J66Z@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Involved in the binding of tRNA to the ribosomes	rpsJ	GO:0001072,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006355,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0015935,GO:0019219,GO:0019222,GO:0019538,GO:0022626,GO:0022627,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043244,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0050789,GO:0050794,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0140110,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:1990904,GO:2000112,GO:2001141	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD1_k127_6402535_1	472759.Nhal_2383	1.217e-228	711.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,1RMYX@1236|Gammaproteobacteria,1WWIK@135613|Chromatiales	135613|Chromatiales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_6402535_0	572477.Alvin_2366	0.0	1193.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,1RNSZ@1236|Gammaproteobacteria,1WW0N@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_6402535_7	572477.Alvin_2367	5.644e-71	242.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,1RN77@1236|Gammaproteobacteria,1WWE7@135613|Chromatiales	135613|Chromatiales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD1_k127_6402535_8	243233.MCA2377	1.916e-69	238.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,1S3WB@1236|Gammaproteobacteria,1XF01@135618|Methylococcales	135618|Methylococcales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD1_k127_6402535_17	1144319.PMI16_00807	1.853e-30	124.0	COG1622@1|root,COG1622@2|Bacteria,1NEC9@1224|Proteobacteria,2VWA0@28216|Betaproteobacteria,477JR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cupredoxin-like domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HKD1_k127_6402535_20	1366050.N234_03550	6.263e-08	54.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,1K36Q@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Metallophosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_6412277_3	316067.Geob_2357	2.096e-112	369.0	COG0577@1|root,COG0577@2|Bacteria,1MX7X@1224|Proteobacteria,42NT4@68525|delta/epsilon subdivisions,2WJFM@28221|Deltaproteobacteria,43T76@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_6412277_1	56780.SYN_00023	2.144e-150	486.0	COG0577@1|root,COG0577@2|Bacteria,1MWBK@1224|Proteobacteria,42PZC@68525|delta/epsilon subdivisions,2WK59@28221|Deltaproteobacteria,2MQUU@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_6412277_4	243231.GSU1162	1.348e-105	347.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,42QF5@68525|delta/epsilon subdivisions,2WK2K@28221|Deltaproteobacteria,43TRN@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	PFAM ABC transporter related	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_6412277_2	909663.KI867150_gene1014	9.086e-129	424.0	COG0845@1|root,COG0845@2|Bacteria,1MUMV@1224|Proteobacteria,42PK1@68525|delta/epsilon subdivisions,2WJ65@28221|Deltaproteobacteria,2MQ6M@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_6412277_5	1123368.AUIS01000004_gene228	1.883e-89	302.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,2NC73@225057|Acidithiobacillales	225057|Acidithiobacillales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_6412277_6	349521.HCH_02661	4.82e-82	278.0	COG0560@1|root,COG0560@2|Bacteria,1MZPG@1224|Proteobacteria,1RRRU@1236|Gammaproteobacteria,1XHS1@135619|Oceanospirillales	135619|Oceanospirillales	E	phosphoserine phosphatase	thrH	-	2.7.1.39,3.1.3.3	ko:K02203	ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00680,map01100,map01110,map01120,map01130,map01230	M00018	R00582,R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD,Hydrolase
HKD1_k127_6412277_0	1173028.ANKO01000017_gene220	4.286e-317	987.0	COG0205@1|root,COG0205@2|Bacteria,1G0N7@1117|Cyanobacteria,1H82M@1150|Oscillatoriales	1117|Cyanobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	-	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_6412277_7	519989.ECTPHS_03969	6.234e-80	274.0	COG2836@1|root,COG2836@2|Bacteria,1RIGJ@1224|Proteobacteria,1S5V1@1236|Gammaproteobacteria,1WXWD@135613|Chromatiales	135613|Chromatiales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K09792	-	-	-	-	ko00000	-	-	-	DsbD_2
HKD1_k127_6412277_8	768671.ThimaDRAFT_2043	3.652e-51	185.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_6412638_11	485913.Krac_1553	0.0009726	42.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_6412638_3	760568.Desku_1403	3.244e-62	231.0	COG3378@1|root,COG3378@2|Bacteria,1TQP9@1239|Firmicutes,24AY6@186801|Clostridia,265ZW@186807|Peptococcaceae	186801|Clostridia	S	Phage plasmid primase, P4	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,Pox_D5,PriCT_1,Prim-Pol
HKD1_k127_6412638_2	631362.Thi970DRAFT_00230	9.29e-102	338.0	COG2801@1|root,COG2801@2|Bacteria,1MVC8@1224|Proteobacteria,1RXYF@1236|Gammaproteobacteria,1WX0Z@135613|Chromatiales	135613|Chromatiales	L	PFAM integrase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve
HKD1_k127_6412638_7	290512.Paes_0078	6.113e-26	109.0	COG2963@1|root,COG2963@2|Bacteria,1FFDM@1090|Chlorobi	1090|Chlorobi	L	PFAM transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD1_k127_6412638_0	1283300.ATXB01000001_gene683	3.913e-197	622.0	COG0014@1|root,COG0014@2|Bacteria,1MUGJ@1224|Proteobacteria,1RMAY@1236|Gammaproteobacteria,1XEVP@135618|Methylococcales	135618|Methylococcales	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_6412638_8	56110.Oscil6304_1842	6.189e-20	99.0	COG4636@1|root,COG4636@2|Bacteria,1G5C5@1117|Cyanobacteria,1HFD4@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_6412638_9	887062.HGR_09209	1.35e-13	73.0	2CEZK@1|root,33KUV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412638_6	1051985.l11_00830	8.184e-27	113.0	COG3209@1|root,COG3209@2|Bacteria,1ND2P@1224|Proteobacteria	1224|Proteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412638_1	208444.JNYY01000013_gene7635	3.415e-146	507.0	COG5412@1|root,COG5412@2|Bacteria,2IB04@201174|Actinobacteria,4E15Y@85010|Pseudonocardiales	201174|Actinobacteria	M	Band 7 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412638_5	65393.PCC7424_2523	3.265e-32	138.0	COG0656@1|root,COG0656@2|Bacteria,1G6K0@1117|Cyanobacteria	1117|Cyanobacteria	T	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157,Ntox11
HKD1_k127_6412638_4	1173028.ANKO01000114_gene6153	4.829e-40	151.0	COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria,1H8T6@1150|Oscillatoriales	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_6429574_2	388051.AUFE01000166_gene71	1.936e-54	199.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,2VMNS@28216|Betaproteobacteria,1KE34@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Involved in initiation control of chromosome replication	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
HKD1_k127_6429574_5	748247.AZKH_2269	5.823e-18	88.0	2E45W@1|root,32SZG@2|Bacteria,1MZSG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6429574_4	1151127.KB906339_gene902	5.334e-29	119.0	COG3794@1|root,COG3794@2|Bacteria,1NKZ5@1224|Proteobacteria,1SHBG@1236|Gammaproteobacteria,1YU31@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD1_k127_6429574_0	1419583.V466_30640	2.549e-174	550.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,1S12Q@1236|Gammaproteobacteria,1YSID@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_6429574_3	479432.Sros_4287	2.409e-54	197.0	COG1132@1|root,COG1413@1|root,COG1132@2|Bacteria,COG1413@2|Bacteria,2I6NK@201174|Actinobacteria	201174|Actinobacteria	V	lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6429574_1	765911.Thivi_2664	1.963e-81	278.0	COG3464@1|root,COG3464@2|Bacteria,1R8B7@1224|Proteobacteria,1SHHY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0236
HKD1_k127_6440946_4	1437824.BN940_14921	3.186e-09	63.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2VIHD@28216|Betaproteobacteria,3T1RX@506|Alcaligenaceae	28216|Betaproteobacteria	D	recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_6440946_5	1129794.C427_2301	2.048e-07	57.0	COG3316@1|root,COG3316@2|Bacteria,1MWZ2@1224|Proteobacteria,1RRC2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_6440946_3	358396.C445_18231	1.112e-29	122.0	arCOG11495@1|root,arCOG11495@2157|Archaea,2XZAM@28890|Euryarchaeota,23XCX@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6440946_0	404589.Anae109_0046	8.54e-113	372.0	COG0451@1|root,COG0451@2|Bacteria,1MXYR@1224|Proteobacteria	1224|Proteobacteria	GM	Nad-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase,NAD_binding_10
HKD1_k127_6440946_1	349124.Hhal_1505	2.485e-40	153.0	COG0664@1|root,COG0664@2|Bacteria,1NI7I@1224|Proteobacteria,1SP73@1236|Gammaproteobacteria	1236|Gammaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_6440946_2	485913.Krac_6255	5.531e-32	126.0	COG3316@1|root,COG3316@2|Bacteria,2G9P3@200795|Chloroflexi	200795|Chloroflexi	L	COGs COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_6440946_6	1123060.JONP01000063_gene3836	4.626e-05	46.0	COG3316@1|root,COG3316@2|Bacteria,1P9SM@1224|Proteobacteria,2TV17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG3316 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_6473328_1	1163617.SCD_n02324	5.135e-100	335.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2VHYK@28216|Betaproteobacteria	28216|Betaproteobacteria	J	Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_6473328_4	1249627.D779_0434	1.964e-53	191.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1WXYW@135613|Chromatiales	135613|Chromatiales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_6473328_3	397945.Aave_3636	1.209e-62	224.0	COG1462@1|root,COG1462@2|Bacteria,1QURH@1224|Proteobacteria,2WH4X@28216|Betaproteobacteria	28216|Betaproteobacteria	M	protein involved in formation of curli polymers	-	-	-	-	-	-	-	-	-	-	-	-	CsgG
HKD1_k127_6473328_5	396588.Tgr7_0985	5.523e-26	111.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,1SD3P@1236|Gammaproteobacteria,1WZFD@135613|Chromatiales	135613|Chromatiales	U	PFAM Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD1_k127_6473328_2	396588.Tgr7_0984	5.052e-97	323.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,1RM8I@1236|Gammaproteobacteria,1WW6U@135613|Chromatiales	135613|Chromatiales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD1_k127_6473328_0	857087.Metme_3291	5.331e-186	591.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,1RMR2@1236|Gammaproteobacteria,1XEX8@135618|Methylococcales	135618|Methylococcales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_6473405_3	243233.MCA1003	1.973e-134	450.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,1RQR7@1236|Gammaproteobacteria,1XED4@135618|Methylococcales	135618|Methylococcales	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD1_k127_6473405_2	522306.CAP2UW1_3100	2.731e-144	466.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2VH2S@28216|Betaproteobacteria,1KQ64@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD1_k127_6473405_8	709797.CSIRO_1995	1.186e-70	247.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2TW0V@28211|Alphaproteobacteria,3JS8Y@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD1_k127_6473405_7	313606.M23134_06922	6.29e-75	264.0	COG1075@1|root,COG1075@2|Bacteria,4NUD6@976|Bacteroidetes	976|Bacteroidetes	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6473405_4	313606.M23134_00683	5.968e-125	417.0	COG4908@1|root,COG4908@2|Bacteria,4PMCQ@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1298)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1298,WES_acyltransf
HKD1_k127_6473405_6	754477.Q7C_2254	3.199e-76	264.0	COG1216@1|root,COG1216@2|Bacteria,1NC31@1224|Proteobacteria,1SS7A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_6473405_1	402881.Plav_3087	2.8e-228	717.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TR3P@28211|Alphaproteobacteria,1JNCA@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_6473405_0	1249627.D779_0428	0.0	1140.0	COG0305@1|root,COG1372@1|root,COG0305@2|Bacteria,COG1372@2|Bacteria,1MUG9@1224|Proteobacteria,1RPM2@1236|Gammaproteobacteria,1WW1X@135613|Chromatiales	135613|Chromatiales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	-	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C,Intein_splicing,LAGLIDADG_3
HKD1_k127_6473405_5	29495.EA26_02465	2.604e-76	264.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,1RM8U@1236|Gammaproteobacteria,1XSJM@135623|Vibrionales	135623|Vibrionales	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	GO:0000270,GO:0003674,GO:0003824,GO:0006022,GO:0006023,GO:0006024,GO:0006807,GO:0008150,GO:0008152,GO:0008784,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0030203,GO:0034645,GO:0036361,GO:0042546,GO:0043170,GO:0044036,GO:0044038,GO:0044085,GO:0044237,GO:0044249,GO:0044260,GO:0047661,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD1_k127_6485090_2	208439.AJAP_00370	9.204e-139	445.0	COG2301@1|root,COG2301@2|Bacteria,2GK5J@201174|Actinobacteria,4E0H5@85010|Pseudonocardiales	201174|Actinobacteria	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.24,4.1.3.25	ko:K08691	ko00630,ko00660,ko00680,ko00720,ko01120,ko01200,map00630,map00660,map00680,map00720,map01120,map01200	M00346,M00373,M00376	R00237,R00473,R00934	RC00307,RC00308,RC00311,RC00407,RC00502,RC01205	ko00000,ko00001,ko00002,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_6485090_6	395493.BegalDRAFT_1238	2.116e-69	244.0	COG2267@1|root,COG2267@2|Bacteria,1PWD0@1224|Proteobacteria,1S8KS@1236|Gammaproteobacteria,462GD@72273|Thiotrichales	72273|Thiotrichales	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_6485090_4	517418.Ctha_1990	2.698e-97	336.0	COG1169@1|root,COG1169@2|Bacteria,1FDKT@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the conversion of chorismate to isochorismate	menF	-	5.4.4.2	ko:K02552	ko00130,ko01053,ko01100,ko01110,ko01130,map00130,map01053,map01100,map01110,map01130	M00116	R01717	RC00588	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_bind
HKD1_k127_6485090_1	696747.NIES39_C02430	3.947e-176	571.0	COG1165@1|root,COG1165@2|Bacteria,1G1FW@1117|Cyanobacteria,1H8TT@1150|Oscillatoriales	1117|Cyanobacteria	H	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)	menD	-	2.2.1.9	ko:K02551	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R08165	RC02186	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M_2,TPP_enzyme_N
HKD1_k127_6485090_5	517418.Ctha_1986	1.324e-70	252.0	COG4948@1|root,COG4948@2|Bacteria,1FE1S@1090|Chlorobi	1090|Chlorobi	H	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C
HKD1_k127_6485090_3	572477.Alvin_1965	3.837e-133	431.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,1RMTU@1236|Gammaproteobacteria,1WWNR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	-	-	5.1.3.2,5.1.3.5	ko:K01784,ko:K12448	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R01473,R02984	RC00289,RC00528	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD1_k127_6485090_0	251229.Chro_0876	3.05e-231	725.0	COG1216@1|root,COG3250@1|root,COG1216@2|Bacteria,COG3250@2|Bacteria,1G2MT@1117|Cyanobacteria,3VNJZ@52604|Pleurocapsales	1117|Cyanobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2_C,Glycos_transf_2
HKD1_k127_6496615_2	1380394.JADL01000011_gene4011	9.791e-115	376.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,2TS2V@28211|Alphaproteobacteria,2JQRW@204441|Rhodospirillales	204441|Rhodospirillales	P	ABC 3 transport family	-	-	-	ko:K02075	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC-3
HKD1_k127_6496615_5	941449.dsx2_1641	5.968e-95	323.0	COG0803@1|root,COG0803@2|Bacteria,1MVW9@1224|Proteobacteria,42MBX@68525|delta/epsilon subdivisions,2WJYG@28221|Deltaproteobacteria,2M807@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_6496615_4	1121033.AUCF01000002_gene574	8.559e-101	334.0	COG1121@1|root,COG1121@2|Bacteria,1MW47@1224|Proteobacteria,2TRJA@28211|Alphaproteobacteria,2JRRS@204441|Rhodospirillales	204441|Rhodospirillales	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02074	-	M00244	-	-	ko00000,ko00002,ko02000	3.A.1.15	-	-	ABC_tran
HKD1_k127_6496615_7	1121468.AUBR01000006_gene349	1.131e-58	215.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	-	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_6496615_8	472759.Nhal_1451	1.507e-56	200.0	COG0432@1|root,COG0432@2|Bacteria,1RH13@1224|Proteobacteria,1S3VP@1236|Gammaproteobacteria,1WY9X@135613|Chromatiales	135613|Chromatiales	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_6496615_6	396588.Tgr7_3237	1.806e-85	289.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,1RMFG@1236|Gammaproteobacteria,1WY2P@135613|Chromatiales	135613|Chromatiales	J	catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD1_k127_6496615_9	555778.Hneap_0439	1.258e-17	86.0	COG2916@1|root,COG2916@2|Bacteria,1N801@1224|Proteobacteria,1SJGP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	dNA-binding protein	-	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
HKD1_k127_6496615_3	396588.Tgr7_0974	2.694e-111	366.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,1RMCZ@1236|Gammaproteobacteria,1WXGX@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD1_k127_6496615_1	390235.PputW619_0708	2.072e-180	571.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,1RMAW@1236|Gammaproteobacteria,1YW0Y@136845|Pseudomonas putida group	1236|Gammaproteobacteria	F	Belongs to the CarA family	carA	GO:0000050,GO:0003674,GO:0003824,GO:0004088,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005951,GO:0006082,GO:0006139,GO:0006206,GO:0006207,GO:0006220,GO:0006221,GO:0006520,GO:0006525,GO:0006526,GO:0006541,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009112,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016053,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019627,GO:0019637,GO:0019693,GO:0019752,GO:0019856,GO:0032991,GO:0034641,GO:0034654,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046390,GO:0046394,GO:0046483,GO:0055086,GO:0071704,GO:0071941,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	iAPECO1_1312.APECO1_1950,iUTI89_1310.UTI89_C0036,ic_1306.c0040	CPSase_sm_chain,GATase
HKD1_k127_6496615_0	349124.Hhal_1775	2.775e-213	666.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,1RPIU@1236|Gammaproteobacteria,1WVW8@135613|Chromatiales	135613|Chromatiales	EF	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_6499095_1	671143.DAMO_0415	7.565e-84	287.0	COG0745@1|root,COG0745@2|Bacteria,2NQWD@2323|unclassified Bacteria	2|Bacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6499095_0	671143.DAMO_0414	9.801e-289	910.0	COG0642@1|root,COG2205@2|Bacteria,2NNNV@2323|unclassified Bacteria	2|Bacteria	T	Osmosensitive K+ channel His kinase sensor domain	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_6509703_4	1125863.JAFN01000001_gene3221	3.92e-43	160.0	COG0410@1|root,COG0410@2|Bacteria,1MU4Z@1224|Proteobacteria,42PIG@68525|delta/epsilon subdivisions,2WPPY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_6509703_3	1249627.D779_3419	2.68e-113	373.0	COG4674@1|root,COG4674@2|Bacteria,1MUBR@1224|Proteobacteria,1RM8F@1236|Gammaproteobacteria,1WXAW@135613|Chromatiales	135613|Chromatiales	S	pfam abc	-	-	-	ko:K11962	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6509703_1	395493.BegalDRAFT_0193	3.097e-173	552.0	COG4177@1|root,COG4177@2|Bacteria,1MUPI@1224|Proteobacteria,1RMAZ@1236|Gammaproteobacteria,460GX@72273|Thiotrichales	72273|Thiotrichales	E	branched-chain amino acid transport system, permease component	-	-	-	ko:K11961	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	BPD_transp_2
HKD1_k127_6509703_2	1125863.JAFN01000001_gene3224	1.239e-168	546.0	COG0559@1|root,COG0559@2|Bacteria,1MVND@1224|Proteobacteria,42MY2@68525|delta/epsilon subdivisions,2WR5C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_6509703_0	1125863.JAFN01000001_gene3225	6.2e-196	613.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,42NVW@68525|delta/epsilon subdivisions,2WMR9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Periplasmic binding protein domain	-	-	-	ko:K01999,ko:K11959	ko02010,ko02024,map02010,map02024	M00237,M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4,3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
HKD1_k127_6518115_7	1454004.AW11_00545	4.437e-54	194.0	COG1883@1|root,COG1883@2|Bacteria,1MV0G@1224|Proteobacteria,2W4KE@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Na+-transporting oxaloacetate decarboxylase beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD1_k127_6518115_8	983917.RGE_11570	3.768e-25	109.0	COG4770@1|root,COG4770@2|Bacteria,1QZ5V@1224|Proteobacteria,2W4TM@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HKD1_k127_6518115_1	983917.RGE_11580	1.268e-241	755.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2W0UT@28216|Betaproteobacteria,1KPA1@119065|unclassified Burkholderiales	28216|Betaproteobacteria	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD1_k127_6518115_4	322710.Avin_29450	3.477e-105	357.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,1RNH3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	malonyl CoA-acyl carrier protein transacylase	-	-	2.3.1.39	ko:K00645,ko:K13935	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD1_k127_6518115_2	869210.Marky_1688	2.912e-145	469.0	COG0026@1|root,COG0026@2|Bacteria,1WITC@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD1_k127_6518115_5	1303518.CCALI_00052	4.383e-72	246.0	COG0041@1|root,COG0041@2|Bacteria	2|Bacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	GO:0003674,GO:0003824,GO:0004638,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009150,GO:0009152,GO:0009165,GO:0009259,GO:0009260,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0016853,GO:0016866,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034023,GO:0034641,GO:0034654,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	iETEC_1333.ETEC_0575,iJN746.PP_5336,iPC815.YPO3076,iUTI89_1310.UTI89_C0551	AIRC
HKD1_k127_6518115_3	768671.ThimaDRAFT_4789	6.714e-134	439.0	COG0547@1|root,COG0547@2|Bacteria,1QDR6@1224|Proteobacteria,1T9UH@1236|Gammaproteobacteria,1WW56@135613|Chromatiales	135613|Chromatiales	E	PFAM Glycosyl transferase, family	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_6518115_6	1123368.AUIS01000003_gene1727	4.264e-68	234.0	COG0219@1|root,COG0219@2|Bacteria,1RCY4@1224|Proteobacteria,1S3PI@1236|Gammaproteobacteria,2NCVP@225057|Acidithiobacillales	225057|Acidithiobacillales	J	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_6518115_0	264198.Reut_A0718	1.27e-244	778.0	COG0438@1|root,COG1216@1|root,COG2227@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG2227@2|Bacteria,1MVIM@1224|Proteobacteria,2VWT8@28216|Betaproteobacteria,1KHRA@119060|Burkholderiaceae	28216|Betaproteobacteria	MQ	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Methyltransf_11
HKD1_k127_6518115_10	232721.Ajs_0550	3.429e-19	92.0	COG2246@1|root,COG2246@2|Bacteria,1NACX@1224|Proteobacteria,2VWGH@28216|Betaproteobacteria,4AFM6@80864|Comamonadaceae	28216|Betaproteobacteria	S	PFAM GtrA family protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD1_k127_6518115_9	1346791.M529_14520	8.028e-22	96.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,2U0P8@28211|Alphaproteobacteria,2K007@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_6534271_5	472759.Nhal_2491	5.258e-65	227.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HKD1_k127_6534271_12	395493.BegalDRAFT_1253	2.223e-09	60.0	COG2608@1|root,COG2608@2|Bacteria	2|Bacteria	P	mercury ion transmembrane transporter activity	copZ	-	-	ko:K07213	ko04978,map04978	-	-	-	ko00000,ko00001	-	-	-	HMA
HKD1_k127_6534271_3	713586.KB900536_gene2245	2.282e-67	233.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1RPB6@1236|Gammaproteobacteria,1WY3D@135613|Chromatiales	135613|Chromatiales	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_6534271_8	945713.IALB_0431	2.484e-24	111.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	-	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
HKD1_k127_6534271_2	1232410.KI421419_gene2503	7.592e-137	441.0	COG1313@1|root,COG1313@2|Bacteria,1NZAK@1224|Proteobacteria,42NYF@68525|delta/epsilon subdivisions,2WIT2@28221|Deltaproteobacteria,43SFJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD1_k127_6534271_10	1217720.ALOX01000046_gene1415	5.529e-17	86.0	COG1669@1|root,COG1669@2|Bacteria,1MZSR@1224|Proteobacteria,2UCA9@28211|Alphaproteobacteria,2JTDJ@204441|Rhodospirillales	204441|Rhodospirillales	S	Nucleotidyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_2
HKD1_k127_6534271_11	368407.Memar_1229	2.669e-13	75.0	COG2361@1|root,arCOG05024@2157|Archaea	2157|Archaea	S	Protein of unknown function DUF86	-	-	-	ko:K07075	-	-	-	-	ko00000	-	-	-	DUF86
HKD1_k127_6534271_9	1408418.JNJH01000010_gene3481	5.534e-18	86.0	COG4118@1|root,COG4118@2|Bacteria,1NH4W@1224|Proteobacteria,2UJBM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Antitoxin Phd_YefM, type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_6534271_0	1163617.SCD_n00954	0.0	1146.0	COG4096@1|root,COG4096@2|Bacteria,1QTS7@1224|Proteobacteria,2VJSS@28216|Betaproteobacteria	28216|Betaproteobacteria	L	type III restriction protein res subunit	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF4145,EcoEI_R_C,HSDR_N,HSDR_N_2,Helicase_C,ResIII
HKD1_k127_6534271_1	1163617.SCD_n00956	2.631e-301	929.0	COG0286@1|root,COG0286@2|Bacteria,1MW3A@1224|Proteobacteria,2VIP4@28216|Betaproteobacteria	28216|Betaproteobacteria	L	N-6 DNA methylase	-	-	2.1.1.72	ko:K03427	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	HSDR_N_2,HsdM_N,N6_Mtase
HKD1_k127_6534271_4	536227.CcarbDRAFT_4478	1.664e-65	239.0	COG0732@1|root,COG0732@2|Bacteria,1V17Q@1239|Firmicutes,24G4I@186801|Clostridia,36K3G@31979|Clostridiaceae	186801|Clostridia	V	Type I restriction modification DNA specificity domain	-	-	3.1.21.3	ko:K01154	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Methylase_S
HKD1_k127_6534271_6	697282.Mettu_3341	6.332e-37	141.0	COG3668@1|root,COG3668@2|Bacteria,1RKAK@1224|Proteobacteria,1SD8T@1236|Gammaproteobacteria,1XGIW@135618|Methylococcales	135618|Methylococcales	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD1_k127_6534271_7	697282.Mettu_3342	1.173e-27	113.0	2CQDU@1|root,32SKZ@2|Bacteria,1N111@1224|Proteobacteria,1SH0Z@1236|Gammaproteobacteria,1XGMT@135618|Methylococcales	135618|Methylococcales	S	Antitoxin ParD	-	-	-	-	-	-	-	-	-	-	-	-	ParD
HKD1_k127_6534271_13	227377.CBU_1753	2.038e-05	50.0	COG5464@1|root,COG5464@2|Bacteria,1P8EY@1224|Proteobacteria,1SUZX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	transposase or invertase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6541243_5	1168067.JAGP01000001_gene1906	5.519e-41	151.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,1S5B2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6541243_7	1236542.BALM01000054_gene2218	5.066e-09	61.0	2DR5Z@1|root,33ABB@2|Bacteria,1NIYJ@1224|Proteobacteria,1SGQ9@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6541243_2	765914.ThisiDRAFT_1160	2.238e-114	374.0	COG1028@1|root,COG1028@2|Bacteria,1MUCH@1224|Proteobacteria,1RNAA@1236|Gammaproteobacteria,1WWKH@135613|Chromatiales	135613|Chromatiales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_6541243_4	713586.KB900536_gene951	3.059e-52	190.0	COG1763@1|root,COG1763@2|Bacteria,1RD3Q@1224|Proteobacteria,1S72P@1236|Gammaproteobacteria,1WY0J@135613|Chromatiales	135613|Chromatiales	H	molybdopterin-guanine dinucleotide biosynthesis protein	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	MobB
HKD1_k127_6541243_3	323261.Noc_2253	7.125e-67	236.0	COG1651@1|root,COG1651@2|Bacteria,1RD39@1224|Proteobacteria,1S3U8@1236|Gammaproteobacteria,1WXSE@135613|Chromatiales	135613|Chromatiales	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	5.3.4.1	ko:K03981	-	-	-	-	ko00000,ko01000,ko02044,ko03110	3.A.7.11.1	-	-	DsbC_N,Thioredoxin_2
HKD1_k127_6541243_0	335283.Neut_0522	1.313e-224	713.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2VH9I@28216|Betaproteobacteria,372W3@32003|Nitrosomonadales	28216|Betaproteobacteria	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD1_k127_6541243_6	1454004.AW11_00956	8.651e-26	113.0	2C5P4@1|root,3310H@2|Bacteria,1P7TH@1224|Proteobacteria,2VZ2D@28216|Betaproteobacteria,1KR36@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6541243_1	187272.Mlg_1037	1.529e-130	428.0	COG0045@1|root,COG1042@1|root,COG1247@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,COG1247@2|Bacteria,1MW98@1224|Proteobacteria,1RPXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Acyl-CoA synthetase (NDP forming)	-	-	-	ko:K09181	-	-	-	-	ko00000	-	-	-	ATP-grasp_5,Acetyltransf_1,Acetyltransf_3,CoA_binding_2,Succ_CoA_lig
HKD1_k127_6546074_4	243231.GSU3323	4.456e-206	648.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,42NN7@68525|delta/epsilon subdivisions,2WJG7@28221|Deltaproteobacteria,43STK@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_6546074_14	401526.TcarDRAFT_0568	3.066e-35	145.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,4H26Q@909932|Negativicutes	909932|Negativicutes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_6546074_7	1121472.AQWN01000005_gene2387	1.056e-109	371.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,260X6@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_6546074_1	472759.Nhal_0595	5.041e-317	979.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,1RMJB@1236|Gammaproteobacteria,1WW7K@135613|Chromatiales	135613|Chromatiales	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_6546074_6	1163617.SCD_n02849	2.024e-123	405.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,2VJJH@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	cbbR	-	-	ko:K21703	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_6546074_5	765914.ThisiDRAFT_1963	8.207e-125	403.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,1RSQ8@1236|Gammaproteobacteria,1WWKV@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM Succinate dehydrogenase fumarate reductase iron-sulphur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD1_k127_6546074_0	765914.ThisiDRAFT_1964	0.0	1045.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,1RMU2@1236|Gammaproteobacteria,1WW72@135613|Chromatiales	135613|Chromatiales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	-	-	1.3.5.4	ko:K00244	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_6546074_10	765914.ThisiDRAFT_1965	6.581e-98	326.0	COG2009@1|root,2ZBTX@2|Bacteria,1RB22@1224|Proteobacteria,1S4JK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	fumarate reductase respiratory complex transmembrane subunit	-	-	-	ko:K00246	ko00020,ko00190,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,map00020,map00190,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020	M00009,M00011,M00150,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_6546074_16	765914.ThisiDRAFT_2697	8.172e-05	47.0	COG3385@1|root,COG3385@2|Bacteria,1QFKR@1224|Proteobacteria,1SCE4@1236|Gammaproteobacteria,1X0CD@135613|Chromatiales	135613|Chromatiales	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_6546074_3	221288.JH992901_gene777	3.27e-265	826.0	COG0033@1|root,COG0033@2|Bacteria,1G0ZB@1117|Cyanobacteria,1JJKI@1189|Stigonemataceae	1117|Cyanobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	pgm	-	5.4.2.2	ko:K01835	ko00010,ko00030,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00549	R00959,R01057,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_6546074_2	686340.Metal_2526	8.489e-274	860.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,1XDZ2@135618|Methylococcales	135618|Methylococcales	P	ATPase, P-type, K Mg Cd Cu Zn Na Ca Na H-transporter	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_6546074_13	330214.NIDE3906	9.313e-38	153.0	COG3218@1|root,COG3218@2|Bacteria	2|Bacteria	Q	ABC-type transport auxiliary lipoprotein component	-	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HKD1_k127_6546074_11	666681.M301_1731	5.889e-57	211.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2VJHA@28216|Betaproteobacteria,2KNAN@206350|Nitrosomonadales	206350|Nitrosomonadales	Q	PFAM Mammalian cell entry related domain protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_6546074_9	472759.Nhal_0468	1.117e-99	337.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,1S2T9@1236|Gammaproteobacteria,1WY3B@135613|Chromatiales	135613|Chromatiales	P	PFAM ABC transporter related	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_6546074_8	472759.Nhal_0469	2.69e-109	365.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,1RYHN@1236|Gammaproteobacteria,1WXIV@135613|Chromatiales	135613|Chromatiales	Q	Permease MlaE	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE,STAS_2
HKD1_k127_6546074_12	1111732.AZOD01000006_gene62	8.553e-38	149.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,1SDCJ@1236|Gammaproteobacteria,1X8TA@135614|Xanthomonadales	135614|Xanthomonadales	L	Staphylococcal nuclease homologues	exoI	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD1_k127_654988_4	757424.Hsero_1518	1.631e-113	370.0	COG0745@1|root,COG0745@2|Bacteria,1MY3D@1224|Proteobacteria,2VI0K@28216|Betaproteobacteria,473K3@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_654988_7	1144319.PMI16_02516	1.35e-18	91.0	2DG9F@1|root,32U6V@2|Bacteria,1N0HX@1224|Proteobacteria,2VTXA@28216|Betaproteobacteria,477TC@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	LTXXQ motif family protein	-	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
HKD1_k127_654988_6	1541065.JRFE01000073_gene3320	2.514e-33	135.0	COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria,3VMW4@52604|Pleurocapsales	1117|Cyanobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD1_k127_654988_1	1266925.JHVX01000006_gene2189	3.53e-200	627.0	COG0577@1|root,COG0577@2|Bacteria,1P0WE@1224|Proteobacteria,2VMKX@28216|Betaproteobacteria,3736K@32003|Nitrosomonadales	28216|Betaproteobacteria	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_654988_3	1266925.JHVX01000006_gene2188	3.141e-117	380.0	COG1136@1|root,COG1136@2|Bacteria,1QT8W@1224|Proteobacteria,2VNQU@28216|Betaproteobacteria,373EK@32003|Nitrosomonadales	28216|Betaproteobacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_654988_2	323848.Nmul_A1503	2.524e-157	503.0	COG0845@1|root,COG0845@2|Bacteria,1NBFC@1224|Proteobacteria,2VN3T@28216|Betaproteobacteria,373M5@32003|Nitrosomonadales	28216|Betaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2
HKD1_k127_654988_0	519989.ECTPHS_08261	2.618e-203	641.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,1RQ8U@1236|Gammaproteobacteria,1WX54@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_654988_5	1397528.Q671_11060	4.799e-73	255.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,1RNKT@1236|Gammaproteobacteria,1XJAC@135619|Oceanospirillales	135619|Oceanospirillales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD1_k127_655423_3	1121033.AUCF01000032_gene2611	4.623e-45	169.0	COG0824@1|root,COG0824@2|Bacteria,1MZB3@1224|Proteobacteria,2U7CU@28211|Alphaproteobacteria,2JTMB@204441|Rhodospirillales	204441|Rhodospirillales	S	Thioesterase-like superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT_2
HKD1_k127_655423_2	640081.Dsui_1326	2.126e-46	175.0	COG0517@1|root,COG0517@2|Bacteria,1RJTX@1224|Proteobacteria,2VTQI@28216|Betaproteobacteria,2KWPB@206389|Rhodocyclales	206389|Rhodocyclales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_655423_4	1283300.ATXB01000001_gene758	1.906e-44	165.0	COG0494@1|root,COG0494@2|Bacteria,1MYSK@1224|Proteobacteria,1SB8U@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.17	ko:K01518	ko00230,ko00240,map00230,map00240	-	R00184,R00969,R01232,R02805	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_655423_0	322710.Avin_45190	6.357e-160	511.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,1RMDH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006780,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009064,GO:0009987,GO:0016053,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046394,GO:0046483,GO:0046501,GO:0046502,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3734,iSBO_1134.SBO_4018	URO-D
HKD1_k127_655423_1	1388763.O165_021215	2.948e-54	192.0	COG0493@1|root,COG0493@2|Bacteria,1MU2H@1224|Proteobacteria,1RMY7@1236|Gammaproteobacteria,1YXV9@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	Glutamate synthase	gltD	GO:0003674,GO:0003824,GO:0004355,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006536,GO:0006537,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0015930,GO:0016053,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0045181,GO:0046394,GO:0055114,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	iEC042_1314.EC042_3503,iYL1228.KPN_03625	Fer4_11,Fer4_20,Pyr_redox_2
HKD1_k127_6560968_11	1254432.SCE1572_02030	6.256e-12	69.0	COG1501@1|root,COG1501@2|Bacteria,1MWNJ@1224|Proteobacteria,430UT@68525|delta/epsilon subdivisions,2WVK7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177,3.2.1.20	ko:K01187,ko:K01811	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_6560968_5	478741.JAFS01000001_gene2005	1.094e-52	196.0	2DPVA@1|root,333IP@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6560968_3	760568.Desku_0093	3.458e-80	282.0	COG1483@1|root,COG1483@2|Bacteria,1TPPM@1239|Firmicutes,250B3@186801|Clostridia,266ZF@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF499)	-	-	-	-	-	-	-	-	-	-	-	-	DUF499
HKD1_k127_6560968_4	880072.Desac_1343	1.383e-63	224.0	2BM7J@1|root,32FR9@2|Bacteria,1NX5G@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6560968_9	1167006.UWK_00986	3.588e-18	85.0	2E3KF@1|root,32YIQ@2|Bacteria,1NC3P@1224|Proteobacteria,432P8@68525|delta/epsilon subdivisions,2WY79@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6560968_6	472759.Nhal_2247	4.154e-29	118.0	2E9MH@1|root,333U5@2|Bacteria,1NDRZ@1224|Proteobacteria,1STW7@1236|Gammaproteobacteria,1X1JP@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6560968_10	631362.Thi970DRAFT_00930	7.21e-17	82.0	2ESIP@1|root,33K3D@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6560968_13	65393.PCC7424_3562	1.675e-05	50.0	2A6KH@1|root,30VE6@2|Bacteria,1GPR8@1117|Cyanobacteria,3KK8V@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6560968_7	593117.TGAM_2018	4.849e-29	121.0	COG1487@1|root,arCOG02225@2157|Archaea,2Y4PV@28890|Euryarchaeota,244FX@183968|Thermococci	183968|Thermococci	V	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_6560968_8	1051632.TPY_0071	3.024e-24	106.0	COG1743@1|root,COG1743@2|Bacteria,1TRIT@1239|Firmicutes,24AVX@186801|Clostridia	186801|Clostridia	L	DNA methylAse	-	-	-	-	-	-	-	-	-	-	-	-	DUF1156,N6_N4_Mtase
HKD1_k127_6560968_2	880072.Desac_1345	1.854e-224	704.0	COG1743@1|root,COG1743@2|Bacteria,1MW7U@1224|Proteobacteria,42RFU@68525|delta/epsilon subdivisions,2WNXH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Protein of unknown function (DUF1156)	-	-	-	ko:K07445	-	-	-	-	ko00000	-	-	-	DUF1156
HKD1_k127_6560968_1	760568.Desku_0096	4.326e-250	792.0	COG0553@1|root,COG0553@2|Bacteria,1TQ5E@1239|Firmicutes,25C98@186801|Clostridia,260VT@186807|Peptococcaceae	186801|Clostridia	L	PFAM DNA RNA helicase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,PLDc_2,SNF2_N
HKD1_k127_6560968_12	709797.CSIRO_1775	4.533e-08	55.0	2AEV9@1|root,314SS@2|Bacteria,1NAGH@1224|Proteobacteria,2UJB1@28211|Alphaproteobacteria,3K0X6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3096)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3096
HKD1_k127_6560968_0	472759.Nhal_2491	0.0	1292.0	COG0366@1|root,COG3281@1|root,COG0366@2|Bacteria,COG3281@2|Bacteria,1MVKX@1224|Proteobacteria,1RMSH@1236|Gammaproteobacteria,1WY9K@135613|Chromatiales	135613|Chromatiales	G	alpha amylase catalytic	-	-	3.2.1.1,5.4.99.16	ko:K05343	ko00500,ko01100,map00500,map01100	-	R01557,R02108,R02112,R11262	RC01816	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HKD1_k127_6565542_3	580332.Slit_2557	9.035e-43	162.0	COG1527@1|root,COG1527@2|Bacteria,1R7PV@1224|Proteobacteria,2W2GY@28216|Betaproteobacteria	28216|Betaproteobacteria	C	ATP synthase (C/AC39) subunit	-	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD1_k127_6565542_0	472759.Nhal_0779	4.872e-196	629.0	COG1269@1|root,COG1269@2|Bacteria,1QGFB@1224|Proteobacteria,1RQRW@1236|Gammaproteobacteria,1WWNC@135613|Chromatiales	135613|Chromatiales	U	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_6565542_2	765914.ThisiDRAFT_0264	2.747e-46	171.0	COG0636@1|root,COG0636@2|Bacteria,1REA9@1224|Proteobacteria,1S51I@1236|Gammaproteobacteria,1WY7C@135613|Chromatiales	135613|Chromatiales	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD1_k127_6565542_4	105559.Nwat_1003	1.192e-29	121.0	COG1436@1|root,COG1436@2|Bacteria,1MZUE@1224|Proteobacteria,1SATX@1236|Gammaproteobacteria,1WYZV@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	-	-	-	-	-	-	-	-	-	-	-	-	ATP-synt_F
HKD1_k127_6565542_1	472759.Nhal_0782	3.857e-56	203.0	COG1390@1|root,COG1390@2|Bacteria,1R8BT@1224|Proteobacteria,1S1WN@1236|Gammaproteobacteria,1WXX4@135613|Chromatiales	135613|Chromatiales	C	V-type proton ATPase subunit E	-	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
HKD1_k127_6565542_5	765913.ThidrDRAFT_0456	0.0001071	44.0	COG1155@1|root,COG1155@2|Bacteria,1MWRR@1224|Proteobacteria,1RSFG@1236|Gammaproteobacteria,1WW9R@135613|Chromatiales	135613|Chromatiales	F	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	-	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD1_k127_6576486_6	398767.Glov_0643	5.102e-35	138.0	COG3608@1|root,COG3608@2|Bacteria,1RG3Y@1224|Proteobacteria,42R0N@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	Desuccinylase aspartoacylase	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HKD1_k127_6576486_4	1283300.ATXB01000002_gene3045	1.574e-65	231.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,1S2WI@1236|Gammaproteobacteria,1XEYK@135618|Methylococcales	135618|Methylococcales	O	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_6576486_5	1170562.Cal6303_1067	1.052e-45	169.0	COG1225@1|root,COG1225@2|Bacteria,1G55Y@1117|Cyanobacteria,1HN2S@1161|Nostocales	1117|Cyanobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_6576486_2	1288494.EBAPG3_30100	9.411e-91	311.0	COG1252@1|root,COG1252@2|Bacteria,1PV2J@1224|Proteobacteria,2WB21@28216|Betaproteobacteria,3722V@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6576486_8	1049564.TevJSym_ak00570	2.052e-12	70.0	2EGR8@1|root,33AHD@2|Bacteria,1N6Z8@1224|Proteobacteria,1SDY4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	FeoC like transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	FeoC
HKD1_k127_6576486_0	118163.Ple7327_3701	4.489e-306	957.0	COG0370@1|root,COG0370@2|Bacteria,1G058@1117|Cyanobacteria,3VK8R@52604|Pleurocapsales	1117|Cyanobacteria	U	Ferrous iron transport protein B	-	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD1_k127_6576486_7	857087.Metme_2328	2.116e-25	107.0	COG1918@1|root,COG1918@2|Bacteria,1N8ZJ@1224|Proteobacteria,1S9TZ@1236|Gammaproteobacteria,1XFKX@135618|Methylococcales	135618|Methylococcales	P	PFAM Ferrous iron transporter, FeoA subunit	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD1_k127_6576486_3	1207076.ALAT01000099_gene2355	9.936e-75	262.0	COG2138@1|root,COG2138@2|Bacteria,1QWDT@1224|Proteobacteria,1RZE1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM cobalamin (vitamin B12) biosynthesis CbiX	-	-	4.99.1.3	ko:K03795	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD1_k127_6576486_1	1207076.ALAT01000099_gene2357	2.369e-114	378.0	COG2241@1|root,COG2242@1|root,COG2241@2|Bacteria,COG2242@2|Bacteria,1MVJX@1224|Proteobacteria,1RPJG@1236|Gammaproteobacteria,1Z45K@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	cobL	-	2.1.1.132,2.1.1.196	ko:K00595,ko:K02191	ko00860,ko01100,map00860,map01100	-	R05149,R05813,R07774	RC00003,RC01279,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	MTS,Methyltransf_31,PCMT,TP_methylase
HKD1_k127_6589573_3	765914.ThisiDRAFT_1511	9.857e-87	291.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RP4T@1236|Gammaproteobacteria,1WX7G@135613|Chromatiales	135613|Chromatiales	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC2	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6589573_10	572477.Alvin_0439	3.797e-28	117.0	COG2010@1|root,COG2010@2|Bacteria,1NDHN@1224|Proteobacteria,1S700@1236|Gammaproteobacteria,1WYGG@135613|Chromatiales	135613|Chromatiales	C	Planctomycete cytochrome C	-	-	-	-	-	-	-	-	-	-	-	-	PSCyt1
HKD1_k127_6589573_5	395493.BegalDRAFT_0026	2.145e-79	272.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,1RP9H@1236|Gammaproteobacteria,460ET@72273|Thiotrichales	72273|Thiotrichales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HKD1_k127_6589573_0	395493.BegalDRAFT_0027	2.032e-201	639.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,1RNCP@1236|Gammaproteobacteria,45ZV4@72273|Thiotrichales	72273|Thiotrichales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD1_k127_6589573_4	1049564.TevJSym_ag00070	3.656e-85	288.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,1RN4Y@1236|Gammaproteobacteria,1J7JW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	P	Cytochrome C1 family	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
HKD1_k127_6589573_6	1049564.TevJSym_ag00050	2.389e-43	162.0	COG2969@1|root,COG2969@2|Bacteria,1MZ2Q@1224|Proteobacteria,1S8WT@1236|Gammaproteobacteria,1J6MW@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Stringent starvation protein B	sspB	GO:0000502,GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0008150,GO:0009376,GO:0009893,GO:0009894,GO:0009896,GO:0010604,GO:0019222,GO:0019899,GO:0031597,GO:0032781,GO:0032991,GO:0042176,GO:0042802,GO:0042803,GO:0043085,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043462,GO:0044093,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0045732,GO:0046983,GO:0048518,GO:0050789,GO:0050790,GO:0051117,GO:0051171,GO:0051173,GO:0051246,GO:0051247,GO:0051336,GO:0051345,GO:0060255,GO:0065007,GO:0065009,GO:0080090,GO:0097159,GO:1901363,GO:1902494,GO:1904949,GO:1905368,GO:1905369,GO:1990904	-	ko:K03600	-	-	-	-	ko00000,ko03021	-	-	-	SspB
HKD1_k127_6589573_8	765912.Thimo_1465	2.927e-39	156.0	COG2823@1|root,COG2823@2|Bacteria,1MUZ2@1224|Proteobacteria,1RY2B@1236|Gammaproteobacteria,1WY1Q@135613|Chromatiales	135613|Chromatiales	S	PFAM transport-associated	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_6589573_9	765912.Thimo_1466	5.066e-31	125.0	COG0792@1|root,COG0792@2|Bacteria,1N6VN@1224|Proteobacteria,1SC8A@1236|Gammaproteobacteria,1WYJE@135613|Chromatiales	135613|Chromatiales	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD1_k127_6589573_2	1149133.ppKF707_3545	1.857e-96	324.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,1RM7U@1236|Gammaproteobacteria,1YDF2@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD1_k127_6589573_1	344747.PM8797T_30886	1.598e-150	489.0	COG2230@1|root,COG2230@2|Bacteria,2IZUD@203682|Planctomycetes	203682|Planctomycetes	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	CMAS
HKD1_k127_6589573_7	1049564.TevJSym_ap00300	3.663e-43	163.0	COG2606@1|root,COG2606@2|Bacteria,1N10Y@1224|Proteobacteria,1SAQE@1236|Gammaproteobacteria,1J6XR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_6672698_0	519989.ECTPHS_03854	2.794e-226	754.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,1RMS6@1236|Gammaproteobacteria,1WWZQ@135613|Chromatiales	135613|Chromatiales	T	response regulator receiver	-	-	-	ko:K02487,ko:K06596	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,Response_reg
HKD1_k127_6672698_1	396588.Tgr7_2901	5.425e-155	514.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,1RMH0@1236|Gammaproteobacteria,1X29W@135613|Chromatiales	135613|Chromatiales	NT	chemotaxis	-	-	-	ko:K02660	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	MCPsignal,PilJ
HKD1_k127_6672698_4	1112217.PPL19_16655	1.269e-28	121.0	COG0835@1|root,COG0835@2|Bacteria,1RCIR@1224|Proteobacteria,1S61F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NT	chemotaxis signal transduction protein	pilI	-	-	ko:K02659	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
HKD1_k127_6672698_3	1131451.O1K_16616	3.312e-51	184.0	COG0745@1|root,COG0745@2|Bacteria,1RDYB@1224|Proteobacteria,1S4CZ@1236|Gammaproteobacteria,1X6HP@135614|Xanthomonadales	135614|Xanthomonadales	KT	response regulator	pilG	-	-	ko:K02657	ko02020,ko02025,map02020,map02025	M00507	-	-	ko00000,ko00001,ko00002,ko02022,ko02035,ko02044	-	-	-	Response_reg
HKD1_k127_6672698_2	472759.Nhal_0215	5.464e-134	434.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,1RMU0@1236|Gammaproteobacteria,1WVY1@135613|Chromatiales	135613|Chromatiales	HJ	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HKD1_k127_6688554_0	396588.Tgr7_1535	0.0	1269.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,1RN03@1236|Gammaproteobacteria,1WXK8@135613|Chromatiales	135613|Chromatiales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_6688554_2	765914.ThisiDRAFT_0484	1.743e-149	481.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,1RNRD@1236|Gammaproteobacteria,1WWFA@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydratase	-	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD1_k127_6688554_3	519989.ECTPHS_08256	1.262e-103	344.0	COG0287@1|root,COG0287@2|Bacteria,1QTZA@1224|Proteobacteria,1T20F@1236|Gammaproteobacteria,1WW2D@135613|Chromatiales	135613|Chromatiales	E	PFAM Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD1_k127_6688554_1	1454004.AW11_03269	0.0	1122.0	COG0296@1|root,COG0296@2|Bacteria,1QTVN@1224|Proteobacteria,2VGZZ@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_6688554_4	522306.CAP2UW1_1623	1.574e-22	103.0	COG5653@1|root,COG5653@2|Bacteria,1RDJC@1224|Proteobacteria,2VS2B@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD1_k127_6713408_2	1049564.TevJSym_ad00370	4.89e-50	180.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria,1J4Y7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2485	M20_dimer,Peptidase_M20
HKD1_k127_6713408_1	713586.KB900536_gene147	1.038e-130	421.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,1RPCS@1236|Gammaproteobacteria,1WVX8@135613|Chromatiales	135613|Chromatiales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
HKD1_k127_6713408_3	187272.Mlg_2696	6.041e-42	155.0	COG2924@1|root,COG2924@2|Bacteria,1MZ2V@1224|Proteobacteria,1S964@1236|Gammaproteobacteria,1WYU9@135613|Chromatiales	135613|Chromatiales	CO	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HKD1_k127_6713408_0	498211.CJA_0530	1.162e-131	437.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,1RMBT@1236|Gammaproteobacteria,1FFRT@10|Cellvibrio	1236|Gammaproteobacteria	L	FES	mutY	GO:0003674,GO:0003824,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016787,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD1_k127_6713408_4	671143.DAMO_2352	6.34e-25	108.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	yeeZ	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	Epimerase,NAD_binding_10,RmlD_sub_bind
HKD1_k127_6730066_0	365044.Pnap_0020	3.336e-102	344.0	COG0665@1|root,COG0665@2|Bacteria,1N1TN@1224|Proteobacteria,2VIIF@28216|Betaproteobacteria,4A9UA@80864|Comamonadaceae	28216|Betaproteobacteria	E	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_6730066_1	1279017.AQYJ01000026_gene396	2.443e-06	50.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_6743732_6	287.DR97_653	0.0004132	43.0	COG0368@1|root,COG0368@2|Bacteria,1RHCC@1224|Proteobacteria,1S4TE@1236|Gammaproteobacteria,1YDQH@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016020,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0071944,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	iECH74115_1262.ECH74115_2837,iECO103_1326.ECO103_2453,iECSP_1301.ECSP_2657,iECs_1301.ECs2787,iG2583_1286.G2583_2502,iUTI89_1310.UTI89_C2230,iZ_1308.Z3152,ic_1306.c2478	CobS
HKD1_k127_6743732_4	1348657.M622_06105	8.382e-80	272.0	COG1881@1|root,COG1881@2|Bacteria,1N0Y4@1224|Proteobacteria,2VJ4C@28216|Betaproteobacteria,2KUB9@206389|Rhodocyclales	206389|Rhodocyclales	S	Phospholipid-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_6743732_5	1249627.D779_3049	5.676e-22	98.0	2EANF@1|root,334QY@2|Bacteria,1N8X0@1224|Proteobacteria,1SCTI@1236|Gammaproteobacteria,1WYZB@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6743732_0	1238182.C882_2067	3.995e-166	533.0	COG4174@1|root,COG4174@2|Bacteria,1MVKE@1224|Proteobacteria,2TQJD@28211|Alphaproteobacteria,2JQ3C@204441|Rhodospirillales	204441|Rhodospirillales	P	transport system, permease component	-	-	-	ko:K13894	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1
HKD1_k127_6743732_3	1173026.Glo7428_0304	6.858e-97	323.0	COG4636@1|root,COG4636@2|Bacteria,1G2CH@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_6743732_1	583355.Caka_1203	2.266e-121	395.0	COG4608@1|root,COG4608@2|Bacteria,46SHJ@74201|Verrucomicrobia,3K7GF@414999|Opitutae	414999|Opitutae	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_6743732_2	794903.OPIT5_07285	1.346e-111	368.0	COG1123@1|root,COG4172@2|Bacteria,46S50@74201|Verrucomicrobia,3K7YP@414999|Opitutae	414999|Opitutae	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_6751575_0	1380350.JIAP01000010_gene5855	2.756e-249	779.0	COG0651@1|root,COG0651@2|Bacteria,1MXRW@1224|Proteobacteria,2TZIX@28211|Alphaproteobacteria,43R8T@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CP	Proton-conducting membrane transporter	hyfB	-	-	-	-	-	-	-	-	-	-	-	Proton_antipo_M
HKD1_k127_6751575_3	316058.RPB_1261	6.707e-134	436.0	COG0650@1|root,COG0650@2|Bacteria,1MXV5@1224|Proteobacteria,2U0GZ@28211|Alphaproteobacteria,3JU8U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH dehydrogenase	hycD	-	-	-	-	-	-	-	-	-	-	-	NADHdh
HKD1_k127_6751575_5	189753.AXAS01000003_gene4562	1.872e-89	300.0	COG4237@1|root,COG4237@2|Bacteria,1NAT8@1224|Proteobacteria,2TUAC@28211|Alphaproteobacteria,3JTK6@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	COG4237 Hydrogenase 4 membrane component (E)	hyfE	-	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_6751575_2	1121861.KB899911_gene1296	1.055e-221	700.0	COG0651@1|root,COG0651@2|Bacteria,1MVBA@1224|Proteobacteria,2TSRU@28211|Alphaproteobacteria,2JR72@204441|Rhodospirillales	204441|Rhodospirillales	CP	Proton-conducting membrane transporter	hyfF	-	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	-	Proton_antipo_M
HKD1_k127_6751575_1	1082933.MEA186_07719	1.382e-231	725.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria,1QUBF@1224|Proteobacteria,2TRE0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	NADH-ubiquinone oxidoreductase chain 49kDa	hycE	-	-	-	-	-	-	-	-	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_6751575_6	1304877.KI519400_gene1382	6.338e-84	280.0	COG3260@1|root,COG3260@2|Bacteria,1QUBE@1224|Proteobacteria,2U279@28211|Alphaproteobacteria,3JTGI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_6751575_4	63737.Npun_F4180	1.697e-121	396.0	COG4715@1|root,COG4715@2|Bacteria,1G37G@1117|Cyanobacteria,1HKDE@1161|Nostocales	1117|Cyanobacteria	S	Zinc finger SWIM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HKD1_k127_6773663_3	1266925.JHVX01000001_gene2629	8.503e-87	294.0	COG0204@1|root,COG0318@1|root,COG0204@2|Bacteria,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2WGHZ@28216|Betaproteobacteria,37225@32003|Nitrosomonadales	28216|Betaproteobacteria	IQ	AMP-dependent synthetase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,Acyltransferase,PP-binding
HKD1_k127_6773663_4	1380394.JADL01000004_gene6090	1.987e-66	230.0	COG0386@1|root,COG0386@2|Bacteria,1RD1R@1224|Proteobacteria,2TU17@28211|Alphaproteobacteria,2JSXW@204441|Rhodospirillales	204441|Rhodospirillales	O	Belongs to the glutathione peroxidase family	-	-	1.11.1.9	ko:K00432	ko00480,ko00590,ko04918,map00480,map00590,map04918	-	R00274,R07034,R07035	RC00011,RC00982	ko00000,ko00001,ko01000	-	-	-	GSHPx
HKD1_k127_6773663_0	396588.Tgr7_2953	4.084e-162	524.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WX0Q@135613|Chromatiales	135613|Chromatiales	O	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD1_k127_6773663_1	269799.Gmet_1906	8.026e-160	509.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,42N4E@68525|delta/epsilon subdivisions,2WUQU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Sulfate ABC transporter, periplasmic sulfate-binding protein	cysP	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HKD1_k127_6773663_2	265072.Mfla_0611	5.898e-92	305.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2VHKY@28216|Betaproteobacteria,2KMAW@206350|Nitrosomonadales	206350|Nitrosomonadales	O	TIGRFAM sulfate ABC transporter, inner membrane subunit CysT	-	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD1_k127_6852637_0	1198114.AciX9_1368	6.085e-114	387.0	COG3464@1|root,COG4584@1|root,COG3464@2|Bacteria,COG4584@2|Bacteria,3Y63B@57723|Acidobacteria,2JMDC@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM transposase IS204 IS1001 IS1096 IS1165 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3
HKD1_k127_6856001_5	1238182.C882_0578	9.115e-138	446.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JPC0@204441|Rhodospirillales	204441|Rhodospirillales	C	malic enzyme	dme	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD1_k127_6856001_4	215803.DB30_8553	3.501e-143	461.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,42N1R@68525|delta/epsilon subdivisions,2WJ7R@28221|Deltaproteobacteria,2YWJD@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6856001_3	1123355.JHYO01000010_gene3527	4.02e-148	472.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,36ZU0@31993|Methylocystaceae	28211|Alphaproteobacteria	S	AAA domain (dynein-related subfamily)	MA20_01295	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD1_k127_6856001_2	414684.RC1_0905	2.495e-186	589.0	COG3825@1|root,COG3825@2|Bacteria,1MUAJ@1224|Proteobacteria,2TS5P@28211|Alphaproteobacteria,2JQTH@204441|Rhodospirillales	204441|Rhodospirillales	S	protein conserved in bacteria	-	-	-	ko:K09989	-	-	-	-	ko00000	-	-	-	VWA_CoxE
HKD1_k127_6856001_13	349521.HCH_02755	5.482e-09	62.0	COG3937@1|root,COG3937@2|Bacteria,1N7X8@1224|Proteobacteria,1T08C@1236|Gammaproteobacteria,1XQHE@135619|Oceanospirillales	135619|Oceanospirillales	S	Poly(hydroxyalcanoate) granule associated protein (phasin)	-	-	-	-	-	-	-	-	-	-	-	-	Phasin
HKD1_k127_6856001_1	396588.Tgr7_2414	1.38e-245	779.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,1T1H2@1236|Gammaproteobacteria,1WWDE@135613|Chromatiales	135613|Chromatiales	T	Belongs to the PEP-utilizing enzyme family	-	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF,GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_6856001_12	1122599.AUGR01000017_gene2960	1.134e-31	130.0	COG3909@1|root,COG3909@2|Bacteria,1N1E5@1224|Proteobacteria,1S4BY@1236|Gammaproteobacteria,1XME0@135619|Oceanospirillales	135619|Oceanospirillales	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HKD1_k127_6856001_8	1121033.AUCF01000008_gene5695	2.44e-79	268.0	COG1187@1|root,COG1187@2|Bacteria,1R9VV@1224|Proteobacteria,2U5H3@28211|Alphaproteobacteria,2JRS2@204441|Rhodospirillales	204441|Rhodospirillales	J	Belongs to the pseudouridine synthase RsuA family	rluE	-	5.4.99.20	ko:K06181	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD1_k127_6856001_0	395493.BegalDRAFT_2012	0.0	1651.0	COG1703@1|root,COG1884@1|root,COG2185@1|root,COG1703@2|Bacteria,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,1RSHX@1236|Gammaproteobacteria,46272@72273|Thiotrichales	72273|Thiotrichales	EI	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly	icmF	-	5.4.99.13	ko:K11942	-	-	-	-	ko00000,ko01000	-	-	-	ArgK,B12-binding,MM_CoA_mutase
HKD1_k127_6856001_10	1123368.AUIS01000006_gene584	2.128e-50	183.0	COG1051@1|root,COG1051@2|Bacteria,1N03W@1224|Proteobacteria,1S970@1236|Gammaproteobacteria,2NCZI@225057|Acidithiobacillales	225057|Acidithiobacillales	F	Belongs to the Nudix hydrolase family. NudJ subfamily	nudJ	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_6856001_7	28072.Nos7524_0364	1.344e-96	322.0	COG0412@1|root,COG0412@2|Bacteria,1G4HV@1117|Cyanobacteria,1HMQR@1161|Nostocales	1117|Cyanobacteria	Q	dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD1_k127_6856001_6	637389.Acaty_c0684	9.96e-110	361.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,1RQQT@1236|Gammaproteobacteria,2NC73@225057|Acidithiobacillales	225057|Acidithiobacillales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_6856001_9	314275.MADE_1019320	1.517e-56	201.0	arCOG14922@1|root,32SW8@2|Bacteria,1N0NY@1224|Proteobacteria,1S5XN@1236|Gammaproteobacteria,46AFB@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Copper resistance protein D	-	-	-	-	-	-	-	-	-	-	-	-	CopD
HKD1_k127_6856001_11	1168065.DOK_15194	4.976e-32	132.0	COG0754@1|root,COG0754@2|Bacteria,1MW6V@1224|Proteobacteria,1RQAP@1236|Gammaproteobacteria,1J6UT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	COG0754 Glutathionylspermidine synthase	gsp	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008884,GO:0008885,GO:0016787,GO:0016810,GO:0016811,GO:0016874,GO:0016879,GO:0016880,GO:0044424,GO:0044444,GO:0044464	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	iECIAI39_1322.ECIAI39_3484	CHAP,GSP_synth
HKD1_k127_6888399_9	630626.EBL_c27290	1.235e-30	123.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,1S1ZY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	GO:0000154,GO:0001510,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0042802,GO:0042803,GO:0043021,GO:0043022,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0044877,GO:0046483,GO:0046983,GO:0070037,GO:0070038,GO:0070475,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD1_k127_6888399_8	765914.ThisiDRAFT_1451	8.833e-37	144.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,1S8W3@1236|Gammaproteobacteria,1WYQV@135613|Chromatiales	135613|Chromatiales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD1_k127_6888399_2	396588.Tgr7_2275	2.613e-73	255.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,1RP00@1236|Gammaproteobacteria,1WY6R@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_6888399_4	211165.AJLN01000120_gene795	7.211e-70	243.0	COG0727@1|root,COG0727@2|Bacteria,1GFCE@1117|Cyanobacteria	1117|Cyanobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	-	-	-	-	-	-	-	-	-	CxxCxxCC
HKD1_k127_6888399_5	1173028.ANKO01000114_gene6173	1.282e-66	233.0	2DME4@1|root,32QWA@2|Bacteria,1G7HW@1117|Cyanobacteria,1HCK0@1150|Oscillatoriales	1117|Cyanobacteria	S	Protein of unknown function (DUF4255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4255
HKD1_k127_6888399_0	489825.LYNGBM3L_05080	7.001e-132	440.0	COG3497@1|root,COG3497@2|Bacteria,1G41S@1117|Cyanobacteria,1H9RA@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage tail sheath protein	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HKD1_k127_6888399_1	489825.LYNGBM3L_05090	3.376e-103	348.0	COG3497@1|root,COG3497@2|Bacteria,1G1XT@1117|Cyanobacteria,1HA7K@1150|Oscillatoriales	1117|Cyanobacteria	S	Phage tail sheath C-terminal domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HKD1_k127_6888399_3	118161.KB235920_gene5972	6.977e-70	239.0	2DB76@1|root,2Z7JZ@2|Bacteria,1G68Y@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HKD1_k127_6888399_6	489825.LYNGBM3L_05110	2.4e-54	192.0	arCOG11412@1|root,31S84@2|Bacteria,1G5ZP@1117|Cyanobacteria,1HBJ9@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6888399_10	1179773.BN6_52000	9.258e-17	81.0	arCOG11411@1|root,33A8Q@2|Bacteria,2GRHE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6888399_7	913865.DOT_6090	1.353e-37	145.0	2DMQT@1|root,32T2H@2|Bacteria,1VA81@1239|Firmicutes,24EAU@186801|Clostridia	186801|Clostridia	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HKD1_k127_6906426_0	765912.Thimo_1760	1.344e-85	294.0	COG1840@1|root,COG1840@2|Bacteria,1MUEG@1224|Proteobacteria,1RQ6Z@1236|Gammaproteobacteria,1WWM0@135613|Chromatiales	135613|Chromatiales	P	extracellular solute-binding protein	-	-	-	ko:K02012	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	SBP_bac_6
HKD1_k127_6906426_2	857087.Metme_4160	0.0001462	53.0	COG1178@1|root,COG1178@2|Bacteria,1MWEV@1224|Proteobacteria,1RP55@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	ABC-type Fe3 transport system permease component	fbpB	-	-	ko:K02011	ko02010,map02010	M00190	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.10	-	-	BPD_transp_1
HKD1_k127_6906856_2	317655.Sala_2641	1.273e-87	310.0	COG0514@1|root,COG0514@2|Bacteria,1QIGJ@1224|Proteobacteria,2U8KQ@28211|Alphaproteobacteria,2K5GQ@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase superfamily c-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HKD1_k127_6906856_0	317655.Sala_2642	4.692e-186	618.0	COG0553@1|root,COG0553@2|Bacteria,1MX6H@1224|Proteobacteria,2VB76@28211|Alphaproteobacteria,2K6KG@204457|Sphingomonadales	204457|Sphingomonadales	L	SNF2 family N-terminal domain	-	-	-	ko:K03580	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	Helicase_C
HKD1_k127_6906856_1	1301098.PKB_1206	4.589e-91	306.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,1RMNQ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006553,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0008652,GO:0009014,GO:0009058,GO:0009066,GO:0009067,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016787,GO:0016810,GO:0016811,GO:0019752,GO:0032153,GO:0042802,GO:0043167,GO:0043169,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046451,GO:0046872,GO:0046914,GO:0050897,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	iECP_1309.ECP_2485	M20_dimer,Peptidase_M20
HKD1_k127_6913640_9	443143.GM18_0461	1.59e-23	102.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,42ZR0@68525|delta/epsilon subdivisions,2WT3B@28221|Deltaproteobacteria,43UQ9@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_6913640_5	443143.GM18_0462	2.304e-62	229.0	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD1_k127_6913640_11	472759.Nhal_1399	4.085e-08	55.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1WXAI@135613|Chromatiales	135613|Chromatiales	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_6913640_10	396588.Tgr7_2687	5.528e-15	82.0	2E6K1@1|root,3316U@2|Bacteria,1NCHT@1224|Proteobacteria,1S72Z@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6913640_1	1131553.JIBI01000016_gene600	1.644e-150	490.0	28H91@1|root,2Z7KU@2|Bacteria,1R4NB@1224|Proteobacteria,2VS45@28216|Betaproteobacteria,373Z4@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6913640_4	1415778.JQMM01000001_gene1409	1.326e-76	261.0	292MF@1|root,2ZQ5C@2|Bacteria,1RCYR@1224|Proteobacteria,1S44V@1236|Gammaproteobacteria,1JAS2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3047)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3047
HKD1_k127_6913640_6	686340.Metal_3435	3.261e-61	217.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,1RN1J@1236|Gammaproteobacteria,1XEXT@135618|Methylococcales	135618|Methylococcales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD1_k127_6913640_8	395493.BegalDRAFT_2718	1.224e-47	175.0	COG1539@1|root,COG1539@2|Bacteria,1MZ8Z@1224|Proteobacteria,1S9B2@1236|Gammaproteobacteria,46173@72273|Thiotrichales	72273|Thiotrichales	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	-	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD1_k127_6913640_7	472759.Nhal_0030	4.63e-48	177.0	COG0801@1|root,COG0801@2|Bacteria,1RHNN@1224|Proteobacteria,1S62M@1236|Gammaproteobacteria,1WYX8@135613|Chromatiales	135613|Chromatiales	H	PFAM 7,8-Dihydro-6-hydroxymethylpterin-pyrophosphokinase, HPPK	-	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD1_k127_6913640_0	743720.Psefu_1819	6.942e-312	969.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,1YV7F@136845|Pseudomonas putida group	1236|Gammaproteobacteria	C	PFAM NADH flavin oxidoreductase NADH oxidase	fadH	-	1.3.1.34	ko:K00219	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_6913640_3	1266914.ATUK01000014_gene2016	5.273e-83	281.0	COG0163@1|root,COG0163@2|Bacteria,1RA0P@1224|Proteobacteria,1RPN1@1236|Gammaproteobacteria,1WWQJ@135613|Chromatiales	135613|Chromatiales	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_6913640_2	870187.Thini_0595	1.163e-136	443.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,1RN2C@1236|Gammaproteobacteria,45ZPW@72273|Thiotrichales	72273|Thiotrichales	P	heavy metal translocating P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	ATPase-cat_bd,E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_6924509_1	1009370.ALO_01789	1.146e-119	393.0	COG1814@1|root,COG1814@2|Bacteria,1UQWP@1239|Firmicutes,4H8S9@909932|Negativicutes	909932|Negativicutes	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_6924509_0	243231.GSU2782	0.0	1088.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria,43S5E@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_6933072_1	1226325.HMPREF1548_01771	5.586e-06	59.0	COG5433@1|root,COG5433@2|Bacteria,1V0EW@1239|Firmicutes,24CZ0@186801|Clostridia,36DX3@31979|Clostridiaceae	186801|Clostridia	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_assoc
HKD1_k127_699272_1	1123376.AUIU01000014_gene675	1.396e-161	523.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_699272_7	232346.JHQL01000003_gene634	5.437e-21	105.0	COG1196@1|root,COG1196@2|Bacteria,1NKHN@1224|Proteobacteria,1SHRR@1236|Gammaproteobacteria,1XMJW@135619|Oceanospirillales	135619|Oceanospirillales	D	Plasmid replication region DNA-binding N-term	-	-	-	-	-	-	-	-	-	-	-	-	KfrA_N
HKD1_k127_699272_9	1122182.KB903833_gene5295	2.753e-05	52.0	COG3747@1|root,COG3747@2|Bacteria,2IJET@201174|Actinobacteria	201174|Actinobacteria	L	Phage terminase, small subunit	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_4
HKD1_k127_699272_8	102129.Lepto7375DRAFT_8306	3.295e-10	63.0	COG3464@1|root,COG3464@2|Bacteria,1G42D@1117|Cyanobacteria,1HHEJ@1150|Oscillatoriales	1117|Cyanobacteria	L	Helix-turn-helix domain of transposase family ISL3	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISL3,HTH_Tnp_ISL3,zf-ISL3
HKD1_k127_699272_5	485913.Krac_1480	5.759e-48	179.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	-	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_699272_0	1190603.AJYD01000015_gene947	1.599e-186	592.0	COG1653@1|root,COG1653@2|Bacteria,1MX9J@1224|Proteobacteria,1RPYT@1236|Gammaproteobacteria,1XUUS@135623|Vibrionales	135623|Vibrionales	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10236	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	SBP_bac_1
HKD1_k127_699272_3	1479237.JMLY01000001_gene218	8.762e-138	443.0	COG1175@1|root,COG1175@2|Bacteria,1MWB7@1224|Proteobacteria,1RZC6@1236|Gammaproteobacteria,46DHU@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Binding-protein-dependent transport system inner membrane component	thuF	-	-	ko:K02025,ko:K10237	ko02010,map02010	M00204,M00207	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.17	-	-	BPD_transp_1
HKD1_k127_699272_4	675812.VHA_002321	1.714e-125	406.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,1RYEC@1236|Gammaproteobacteria,1Y25I@135623|Vibrionales	135623|Vibrionales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10238	ko02010,map02010	M00204	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.17	-	-	BPD_transp_1
HKD1_k127_699272_2	502025.Hoch_3143	1.986e-140	454.0	COG3842@1|root,COG3842@2|Bacteria,1MU3I@1224|Proteobacteria,42NVJ@68525|delta/epsilon subdivisions,2WJN1@28221|Deltaproteobacteria,2YUPT@29|Myxococcales	28221|Deltaproteobacteria	P	TOBE domain	-	-	3.6.3.20	ko:K05816,ko:K10111,ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00198,M00200,M00201,M00204,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.1,3.A.1.1.3	-	-	ABC_tran,TOBE,TOBE_2
HKD1_k127_699272_6	485913.Krac_3731	1.593e-40	156.0	COG0732@1|root,COG0732@2|Bacteria,2G7K5@200795|Chloroflexi	200795|Chloroflexi	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_699272_10	357808.RoseRS_2292	4.165e-05	46.0	COG0732@1|root,COG0732@2|Bacteria,2G7K5@200795|Chloroflexi,377SZ@32061|Chloroflexia	200795|Chloroflexi	V	type I restriction modification DNA specificity domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_7022489_2	1049564.TevJSym_bc00200	1.739e-76	261.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,1S26C@1236|Gammaproteobacteria,1J5UI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iECABU_c1320.ECABU_c13120,ic_1306.c1370	Thymidylate_kin
HKD1_k127_7022489_3	395493.BegalDRAFT_1778	9.76e-73	256.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,1RNYA@1236|Gammaproteobacteria,460WJ@72273|Thiotrichales	72273|Thiotrichales	L	TIGRFAM DNA polymerase III, delta	-	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD1_k127_7022489_5	396588.Tgr7_1827	1.381e-39	150.0	COG3215@1|root,COG3215@2|Bacteria,1RGWZ@1224|Proteobacteria,1S4YE@1236|Gammaproteobacteria,1WYAQ@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type IV pilus assembly PilZ	-	-	-	ko:K02676	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilZ
HKD1_k127_7022489_4	1238182.C882_2237	9.875e-60	212.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2JS96@204441|Rhodospirillales	204441|Rhodospirillales	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_7022489_0	522306.CAP2UW1_1590	0.0	1965.0	COG0296@1|root,COG1523@1|root,COG0296@2|Bacteria,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,2VH8E@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_7022489_1	713587.THITH_05130	2.974e-82	277.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD1_k127_7030695_2	1121396.KB893115_gene3166	1.577e-101	365.0	COG1672@1|root,COG3209@1|root,COG1672@2|Bacteria,COG3209@2|Bacteria,1R2HA@1224|Proteobacteria,430VH@68525|delta/epsilon subdivisions,2WVMY@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7030695_7	670292.JH26_11315	0.0001534	54.0	COG1674@1|root,COG4783@1|root,COG1674@2|Bacteria,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	ftsK	-	-	ko:K02660,ko:K03466,ko:K07474,ko:K19175	ko02020,ko02025,map02020,map02025	-	-	-	ko00000,ko00001,ko02035,ko02044,ko02048,ko03036	3.A.12	-	-	FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_7030695_5	1499967.BAYZ01000076_gene778	6.099e-47	186.0	2EKYY@1|root,33ENF@2|Bacteria	2|Bacteria	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
HKD1_k127_7030695_6	317936.Nos7107_1584	9.978e-16	77.0	2B3FR@1|root,31W4Q@2|Bacteria,1GJ19@1117|Cyanobacteria,1HQ0K@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7030695_4	83406.HDN1F_22360	4.821e-72	246.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,1S3WC@1236|Gammaproteobacteria,1J86G@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Transferase hexapeptide repeat	yrdA	-	-	-	-	-	-	-	-	-	-	-	Hexapep,Hexapep_2
HKD1_k127_7030695_1	1163617.SCD_n01287	4.895e-124	406.0	COG0714@1|root,COG0714@2|Bacteria,1MUFN@1224|Proteobacteria,2VKJJ@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM ATPase associated with various cellular activities, AAA_3	moxR	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_7030695_3	519989.ECTPHS_05065	1.486e-84	295.0	COG1721@1|root,COG1721@2|Bacteria,1R3QD@1224|Proteobacteria,1S5F7@1236|Gammaproteobacteria,1WWD0@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_7030695_0	1163617.SCD_n01285	1.194e-183	597.0	COG1305@1|root,COG1305@2|Bacteria,1MWCE@1224|Proteobacteria,2VHZP@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM transglutaminase domain protein	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HKD1_k127_7039554_8	502025.Hoch_3346	9.376e-53	202.0	COG1262@1|root,COG2114@1|root,COG5635@1|root,COG1262@2|Bacteria,COG2114@2|Bacteria,COG5635@2|Bacteria,1R66C@1224|Proteobacteria	1224|Proteobacteria	T	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,NACHT
HKD1_k127_7039554_7	472759.Nhal_1493	1.838e-68	248.0	COG0443@1|root,COG1672@1|root,COG0443@2|Bacteria,COG1672@2|Bacteria	2|Bacteria	O	unfolded protein binding	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,SrfB,WD40
HKD1_k127_7039554_6	909663.KI867150_gene2838	1.513e-131	432.0	COG0420@1|root,COG0420@2|Bacteria,1MXMJ@1224|Proteobacteria,42Q5U@68525|delta/epsilon subdivisions,2WINF@28221|Deltaproteobacteria,2MRY7@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	Calcineurin-like phosphoesterase superfamily domain	sbcD-1	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
HKD1_k127_7039554_2	909663.KI867150_gene2839	7.02e-206	683.0	COG1196@1|root,COG4717@1|root,COG1196@2|Bacteria,COG4717@2|Bacteria,1MVAW@1224|Proteobacteria,42MYC@68525|delta/epsilon subdivisions,2WJXA@28221|Deltaproteobacteria,2MSDD@213462|Syntrophobacterales	28221|Deltaproteobacteria	D	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_27
HKD1_k127_7039554_1	1166948.JPZL01000003_gene648	2.945e-267	839.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,1RMMQ@1236|Gammaproteobacteria,1XIN2@135619|Oceanospirillales	135619|Oceanospirillales	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_7039554_0	396588.Tgr7_2893	0.0	1016.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,1RMWP@1236|Gammaproteobacteria,1WVWH@135613|Chromatiales	135613|Chromatiales	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_7039554_5	1120999.JONM01000014_gene2878	2.892e-178	562.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2VHHG@28216|Betaproteobacteria,2KPNE@206351|Neisseriales	206351|Neisseriales	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_7039554_3	396588.Tgr7_2891	1.28e-192	608.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,1RMUQ@1236|Gammaproteobacteria,1WX6Z@135613|Chromatiales	135613|Chromatiales	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_7039554_4	396588.Tgr7_2890	2.245e-186	596.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,1RMW3@1236|Gammaproteobacteria,1WXEF@135613|Chromatiales	135613|Chromatiales	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_7047334_23	478741.JAFS01000001_gene2161	4.444e-29	122.0	COG0056@1|root,COG0056@2|Bacteria,46YUW@74201|Verrucomicrobia,37FZ6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	-	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C
HKD1_k127_7047334_19	472759.Nhal_2237	5.523e-51	190.0	COG0711@1|root,COG0712@1|root,COG0711@2|Bacteria,COG0712@2|Bacteria,1R6C0@1224|Proteobacteria,1S4NA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	-	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B,OSCP
HKD1_k127_7047334_24	472759.Nhal_2238	2.164e-28	117.0	COG0636@1|root,COG0636@2|Bacteria,1NAIE@1224|Proteobacteria,1SA80@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	-	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_7047334_16	472759.Nhal_2239	3.811e-87	293.0	COG0356@1|root,COG0356@2|Bacteria,1RBEV@1224|Proteobacteria,1T170@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	it plays a direct role in the translocation of protons across the membrane	-	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_7047334_25	338966.Ppro_0849	1.251e-25	109.0	2E70X@1|root,331JP@2|Bacteria,1N81S@1224|Proteobacteria	1224|Proteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HKD1_k127_7047334_21	472759.Nhal_2241	1.159e-42	159.0	COG0355@1|root,COG0355@2|Bacteria,1N1NE@1224|Proteobacteria,1S9B5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	epsilon subunit	-	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
HKD1_k127_7047334_0	1288826.MSNKSG1_00556	2.835e-234	732.0	COG0055@1|root,COG0055@2|Bacteria,1N6UZ@1224|Proteobacteria,1RNQW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	-	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_7047334_15	1249627.D779_1595	8.263e-94	311.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,1RNQZ@1236|Gammaproteobacteria,1WWFN@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_7047334_5	768671.ThimaDRAFT_4682	5.628e-170	542.0	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,1S3T6@1236|Gammaproteobacteria,1WWE6@135613|Chromatiales	135613|Chromatiales	H	PFAM 6-pyruvoyl tetrahydropterin	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_7047334_3	243233.MCA2474	4.293e-183	586.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1XE5A@135618|Methylococcales	135618|Methylococcales	T	SMART Signal transduction response regulator, receiver region	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_7047334_10	472759.Nhal_3134	3.258e-124	413.0	COG4191@1|root,COG4191@2|Bacteria,1MVK7@1224|Proteobacteria,1S0T1@1236|Gammaproteobacteria,1X0GA@135613|Chromatiales	135613|Chromatiales	T	PFAM ATP-binding region	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_7047334_2	1234364.AMSF01000033_gene402	1.354e-193	613.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,1RQE4@1236|Gammaproteobacteria,1X59Z@135614|Xanthomonadales	135614|Xanthomonadales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD1_k127_7047334_11	1123255.JHYS01000010_gene439	1.682e-120	397.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2VHIN@28216|Betaproteobacteria,4AFKC@80864|Comamonadaceae	28216|Betaproteobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	tal	-	2.2.1.2,5.3.1.9	ko:K00616,ko:K13810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00004,M00007,M00114	R01827,R02739,R02740,R03321	RC00376,RC00439,RC00563,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_7047334_13	159087.Daro_1418	1.01e-109	362.0	28I9W@1|root,2Z8CH@2|Bacteria,1QCN6@1224|Proteobacteria,2VM9W@28216|Betaproteobacteria,2KV5B@206389|Rhodocyclales	206389|Rhodocyclales	S	SIR2-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SIR2_2
HKD1_k127_7047334_6	519989.ECTPHS_11370	1.578e-168	546.0	COG4191@1|root,COG4191@2|Bacteria,1MXRR@1224|Proteobacteria,1RQ1E@1236|Gammaproteobacteria,1WW44@135613|Chromatiales	135613|Chromatiales	T	nitrogen fixation negative regulator NifL	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS,PAS_9
HKD1_k127_7047334_1	765914.ThisiDRAFT_1339	1.604e-222	700.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,1T1G7@1236|Gammaproteobacteria,1WX1Q@135613|Chromatiales	135613|Chromatiales	KT	Fis Family	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
HKD1_k127_7047334_17	339670.Bamb_4132	7.626e-79	273.0	COG0583@1|root,COG0583@2|Bacteria,1MXRP@1224|Proteobacteria,2VRKA@28216|Betaproteobacteria,1KGFZ@119060|Burkholderiaceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_7047334_4	1005048.CFU_2937	3.851e-179	567.0	COG0683@1|root,COG0683@2|Bacteria,1N76S@1224|Proteobacteria,2VKWN@28216|Betaproteobacteria,47615@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	amino acid transport system, periplasmic component	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_7047334_8	1144319.PMI16_03255	7.494e-136	438.0	COG0559@1|root,COG0559@2|Bacteria,1R5TP@1224|Proteobacteria,2VMMJ@28216|Betaproteobacteria,476KV@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7047334_9	757424.Hsero_2933	3.282e-127	414.0	COG4177@1|root,COG4177@2|Bacteria,1R91I@1224|Proteobacteria,2VIIS@28216|Betaproteobacteria,476DM@75682|Oxalobacteraceae	28216|Betaproteobacteria	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_7047334_12	1005048.CFU_2940	5.518e-116	380.0	COG0411@1|root,COG0411@2|Bacteria,1MUTY@1224|Proteobacteria,2VPNQ@28216|Betaproteobacteria,476M9@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	AAA domain	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_7047334_14	1144342.PMI40_02350	4.052e-108	354.0	COG0410@1|root,COG0410@2|Bacteria,1MVVC@1224|Proteobacteria,2VIV4@28216|Betaproteobacteria,4762R@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	amino acid transport system, ATPase component	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD1_k127_7047334_26	1000569.HMPREF1040_0560	0.0006651	43.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes	1239|Firmicutes	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	GO:0000287,GO:0003674,GO:0003824,GO:0004765,GO:0005488,GO:0006082,GO:0006520,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019438,GO:0019632,GO:0019752,GO:0032787,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046872,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI
HKD1_k127_7047334_18	243160.BMAA0909	1.355e-52	188.0	COG0784@1|root,COG0784@2|Bacteria,1QUN7@1224|Proteobacteria,2VSTE@28216|Betaproteobacteria,1KII4@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_7047334_7	316274.Haur_2523	2.054e-154	520.0	COG0784@1|root,COG4191@1|root,COG5002@1|root,COG0784@2|Bacteria,COG4191@2|Bacteria,COG5002@2|Bacteria,2G7PG@200795|Chloroflexi	2|Bacteria	T	ATP-binding region, ATPase domain protein	-	-	2.7.13.3	ko:K02482,ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,dCache_1
HKD1_k127_7047334_22	1121033.AUCF01000013_gene1567	3.764e-35	140.0	COG2847@1|root,COG2847@2|Bacteria,1MZ3M@1224|Proteobacteria,2UBUR@28211|Alphaproteobacteria,2JTEB@204441|Rhodospirillales	204441|Rhodospirillales	S	Pfam:DUF461	-	-	-	ko:K09796	-	-	-	-	ko00000,ko03110	-	-	-	PCuAC
HKD1_k127_7047334_20	1249627.D779_3151	2.858e-43	161.0	COG0760@1|root,COG0760@2|Bacteria,1QUCX@1224|Proteobacteria,1S6X5@1236|Gammaproteobacteria,1WY5W@135613|Chromatiales	135613|Chromatiales	O	PFAM NifZ	-	-	-	ko:K02597	-	-	-	-	ko00000	-	-	-	NifZ
HKD1_k127_7062073_0	395493.BegalDRAFT_1750	0.0	1110.0	COG1305@1|root,COG4196@1|root,COG1305@2|Bacteria,COG4196@2|Bacteria,1MVAG@1224|Proteobacteria,1RMX2@1236|Gammaproteobacteria,461RZ@72273|Thiotrichales	72273|Thiotrichales	E	Putative amidoligase enzyme (DUF2126)	-	-	-	-	-	-	-	-	-	-	-	-	Bact_transglu_N,DUF2126,Transglut_core
HKD1_k127_7062073_1	1123228.AUIH01000032_gene1739	9.169e-127	409.0	COG2308@1|root,COG2308@2|Bacteria,1MUAD@1224|Proteobacteria,1RNAF@1236|Gammaproteobacteria,1XICW@135619|Oceanospirillales	135619|Oceanospirillales	S	Circularly permuted ATP-grasp type 2	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD1_k127_7066173_3	1049564.TevJSym_al00460	3.315e-77	265.0	COG1663@1|root,COG1663@2|Bacteria,1MU8G@1224|Proteobacteria,1RMMW@1236|Gammaproteobacteria,1J5MP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	F	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	GO:0000271,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005975,GO:0005976,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008653,GO:0008654,GO:0009029,GO:0009058,GO:0009059,GO:0009103,GO:0009244,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016020,GO:0016051,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019637,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044260,GO:0044262,GO:0044264,GO:0044464,GO:0046401,GO:0046467,GO:0046493,GO:0071704,GO:0071944,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	iBWG_1329.BWG_0767,iECDH10B_1368.ECDH10B_0985,iPC815.YPO1396	LpxK
HKD1_k127_7066173_5	314278.NB231_17033	8.819e-34	138.0	COG0848@1|root,COG0848@2|Bacteria,1RI4M@1224|Proteobacteria,1S4GX@1236|Gammaproteobacteria,1X2G8@135613|Chromatiales	135613|Chromatiales	U	Biopolymer transport protein ExbD/TolR	-	-	-	-	-	-	-	-	-	-	-	-	ExbD
HKD1_k127_7066173_4	472759.Nhal_0529	1.54e-65	230.0	COG0811@1|root,COG0811@2|Bacteria,1QNJ1@1224|Proteobacteria,1RQWT@1236|Gammaproteobacteria,1WX5A@135613|Chromatiales	135613|Chromatiales	U	PFAM MotA TolQ ExbB proton channel	-	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD1_k127_7066173_0	396588.Tgr7_0696	6.232e-209	662.0	COG2918@1|root,COG2918@2|Bacteria,1MW9B@1224|Proteobacteria,1RPNQ@1236|Gammaproteobacteria,1WWFZ@135613|Chromatiales	135613|Chromatiales	H	Belongs to the glutamate--cysteine ligase type 1 family. Type 1 subfamily	gshA	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	Glu_cys_ligase
HKD1_k127_7066173_2	243233.MCA2880	6.411e-126	410.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,1RN2H@1236|Gammaproteobacteria,1XER0@135618|Methylococcales	135618|Methylococcales	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD1_k127_7066173_1	435908.IDSA_08365	1.493e-172	550.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,1RMV1@1236|Gammaproteobacteria,2QF2N@267893|Idiomarinaceae	1236|Gammaproteobacteria	E	acetylornithine aminotransferase	argD	GO:0003674,GO:0003824,GO:0003992,GO:0004069,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006553,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008483,GO:0008652,GO:0009016,GO:0009058,GO:0009064,GO:0009066,GO:0009067,GO:0009084,GO:0009085,GO:0009089,GO:0009987,GO:0016053,GO:0016740,GO:0016769,GO:0019752,GO:0019842,GO:0030170,GO:0033359,GO:0036094,GO:0042450,GO:0042802,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046451,GO:0048037,GO:0050662,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.6.1.11,2.6.1.17,2.6.1.81	ko:K00821,ko:K00840	ko00220,ko00300,ko00330,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map00330,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04217,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	iSFV_1184.SFV_3365,iSF_1195.SF3378,iSFxv_1172.SFxv_3689,iSSON_1240.SSON_3490,iS_1188.S4385	Aminotran_3
HKD1_k127_7066173_6	713586.KB900536_gene1873	2.653e-17	83.0	COG5481@1|root,COG5481@2|Bacteria,1QB94@1224|Proteobacteria,1SHNI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HKD1_k127_7086414_5	765912.Thimo_2007	2.031e-214	669.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_7086414_20	713586.KB900536_gene982	1.726e-18	86.0	2CDU3@1|root,33AS4@2|Bacteria,1NGWQ@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2970)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2970
HKD1_k127_7086414_13	1255043.TVNIR_2828	5.026e-68	239.0	COG1988@1|root,COG1988@2|Bacteria,1MZEI@1224|Proteobacteria,1S9P5@1236|Gammaproteobacteria,1WXS7@135613|Chromatiales	135613|Chromatiales	S	membrane-bound metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	YdjM
HKD1_k127_7086414_8	631362.Thi970DRAFT_01762	1.342e-149	481.0	COG5345@1|root,COG5345@2|Bacteria,1MWVH@1224|Proteobacteria,1RP5X@1236|Gammaproteobacteria,1WVX3@135613|Chromatiales	135613|Chromatiales	S	PFAM Uncharacterised conserved protein UCP029693	-	-	-	-	-	-	-	-	-	-	-	-	DUF2333
HKD1_k127_7086414_0	395493.BegalDRAFT_2503	0.0	1387.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,1RNEB@1236|Gammaproteobacteria,45ZRC@72273|Thiotrichales	72273|Thiotrichales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_7086414_14	1452718.JBOY01000028_gene150	6.141e-64	231.0	COG2755@1|root,COG2755@2|Bacteria,1RCXZ@1224|Proteobacteria,1S3QU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	COG2755 Lysophospholipase L1 and related esterases	tesA	GO:0003674,GO:0003824,GO:0004620,GO:0004622,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016289,GO:0016290,GO:0016298,GO:0016787,GO:0016788,GO:0016790,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044238,GO:0044464,GO:0047617,GO:0052689,GO:0071704,GO:0140096,GO:1901564	3.1.1.5	ko:K10804	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	iECED1_1282.ECED1_0521,iLF82_1304.LF82_2242,iNRG857_1313.NRG857_02365	Lipase_GDSL_2
HKD1_k127_7086414_11	1384056.N787_02440	4.374e-89	299.0	COG4181@1|root,COG4181@2|Bacteria,1MXG9@1224|Proteobacteria,1RMG1@1236|Gammaproteobacteria,1X623@135614|Xanthomonadales	135614|Xanthomonadales	Q	ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7086414_3	396588.Tgr7_2114	1.591e-251	801.0	COG3127@1|root,COG3127@2|Bacteria,1MU9R@1224|Proteobacteria,1RM8Y@1236|Gammaproteobacteria,1WX8V@135613|Chromatiales	135613|Chromatiales	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD1_k127_7086414_6	45157.CMP300CT	3.003e-180	593.0	COG0296@1|root,KOG0470@2759|Eukaryota	2759|Eukaryota	G	1,4-alpha-glucan branching enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7086414_21	1027292.HMPREF9372_1226	2.122e-10	66.0	COG5464@1|root,COG5464@2|Bacteria,1UGME@1239|Firmicutes,4HEK5@91061|Bacilli	91061|Bacilli	S	High confidence in function and specificity	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Transposase_31
HKD1_k127_7086414_17	1502851.FG93_05453	2.22e-41	154.0	COG2154@1|root,COG2154@2|Bacteria,1RH99@1224|Proteobacteria,2UCDA@28211|Alphaproteobacteria,3K0PI@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	H	Pterin 4 alpha carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD1_k127_7086414_15	519989.ECTPHS_03192	2.816e-50	180.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,1S8Z7@1236|Gammaproteobacteria,1WYBV@135613|Chromatiales	135613|Chromatiales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD1_k127_7086414_2	1122164.JHWF01000004_gene15	0.0	1076.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,1RMH3@1236|Gammaproteobacteria,1JCZN@118969|Legionellales	118969|Legionellales	O	C-terminal, D2-small domain, of ClpB protein	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_7086414_4	472759.Nhal_0327	1.487e-215	683.0	COG1080@1|root,COG1080@2|Bacteria,1MUT8@1224|Proteobacteria,1RN6R@1236|Gammaproteobacteria,1WWBU@135613|Chromatiales	135613|Chromatiales	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	-	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_7086414_19	1033802.SSPSH_000347	2.205e-29	119.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,1SCXX@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Phosphotransferase System	ptsO	GO:0003674,GO:0003824,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006808,GO:0006810,GO:0008150,GO:0008152,GO:0008643,GO:0009401,GO:0009987,GO:0010033,GO:0010243,GO:0016310,GO:0016740,GO:0016772,GO:0019538,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0050789,GO:0050896,GO:0051179,GO:0051234,GO:0065007,GO:0071702,GO:0071704,GO:1901564,GO:1901698	-	ko:K08485,ko:K11189	ko02060,map02060	-	-	-	ko00000,ko00001,ko02000	4.A.2.1	-	-	PTS-HPr
HKD1_k127_7086414_9	396588.Tgr7_0722	5.731e-100	333.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,1RNJX@1236|Gammaproteobacteria,1WW9Z@135613|Chromatiales	135613|Chromatiales	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD1_k127_7086414_12	765914.ThisiDRAFT_0196	1.673e-73	258.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,1S02U@1236|Gammaproteobacteria,1WX9F@135613|Chromatiales	135613|Chromatiales	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr)	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD1_k127_7086414_16	314278.NB231_05781	4.693e-47	173.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,1S668@1236|Gammaproteobacteria,1WYAA@135613|Chromatiales	135613|Chromatiales	G	PTS IIA-like nitrogen-regulatory protein PtsN	-	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD1_k127_7086414_18	713586.KB900536_gene1419	5.589e-39	149.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,1S8U1@1236|Gammaproteobacteria,1WYWY@135613|Chromatiales	135613|Chromatiales	J	Sigma 54 modulation protein	-	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HKD1_k127_7086414_7	1288826.MSNKSG1_09018	1.302e-173	557.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,1RMY0@1236|Gammaproteobacteria,4642B@72275|Alteromonadaceae	1236|Gammaproteobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	GO:0000976,GO:0001067,GO:0001130,GO:0001216,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005575,GO:0006355,GO:0008150,GO:0009889,GO:0009891,GO:0009893,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0032991,GO:0032993,GO:0043565,GO:0044212,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2001141	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_7086414_10	1123393.KB891317_gene2424	4.194e-97	334.0	COG0845@1|root,COG0845@2|Bacteria,1PQHB@1224|Proteobacteria,2VHZR@28216|Betaproteobacteria,1KSQC@119069|Hydrogenophilales	119069|Hydrogenophilales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7086414_1	292415.Tbd_1746	0.0	1262.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,2VHCZ@28216|Betaproteobacteria,1KS6S@119069|Hydrogenophilales	119069|Hydrogenophilales	P	Protein export membrane protein	-	-	-	ko:K07239	-	-	-	-	ko00000	2.A.6.1	-	-	ACR_tran
HKD1_k127_7089306_6	449447.MAE_57720	7.18e-15	76.0	COG1598@1|root,COG1598@2|Bacteria,1GF2K@1117|Cyanobacteria	1117|Cyanobacteria	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_7089306_5	1499967.BAYZ01000096_gene4319	4.959e-27	111.0	COG1724@1|root,COG1724@2|Bacteria	2|Bacteria	N	mRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_7089306_7	1255043.TVNIR_3041	4.018e-13	73.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,1RP5P@1236|Gammaproteobacteria,1WXEY@135613|Chromatiales	135613|Chromatiales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_7089306_2	1454004.AW11_03229	3.221e-32	128.0	COG3547@1|root,COG3547@2|Bacteria,1MUKH@1224|Proteobacteria,2VNZG@28216|Betaproteobacteria	28216|Betaproteobacteria	L	transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_7089306_8	1255043.TVNIR_0775	5.061e-08	55.0	COG3547@1|root,COG3547@2|Bacteria	2|Bacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_7089306_3	583355.Caka_2250	7.258e-30	125.0	COG5074@1|root,COG5074@2|Bacteria,46W5A@74201|Verrucomicrobia,3K8CX@414999|Opitutae	414999|Opitutae	U	SNAP receptor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7089306_1	1894.JOER01000006_gene719	8.192e-44	175.0	COG0631@1|root,COG0631@2|Bacteria,2GMNH@201174|Actinobacteria	201174|Actinobacteria	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD1_k127_7089306_4	909663.KI867150_gene307	2.257e-29	122.0	COG1811@1|root,COG1811@2|Bacteria,1MX1D@1224|Proteobacteria,42S9G@68525|delta/epsilon subdivisions,2WNUQ@28221|Deltaproteobacteria,2MQH1@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
HKD1_k127_7089306_0	395493.BegalDRAFT_2350	6.42e-48	179.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,1RQJ9@1236|Gammaproteobacteria,460R1@72273|Thiotrichales	72273|Thiotrichales	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD_D23
HKD1_k127_7091868_0	768671.ThimaDRAFT_4273	9.928e-76	264.0	COG5464@1|root,COG5464@2|Bacteria	2|Bacteria	S	double-stranded DNA endodeoxyribonuclease activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2887,DUF4351
HKD1_k127_7091868_1	292415.Tbd_1308	1.37e-26	112.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VRBM@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_7122212_2	314278.NB231_10828	2.113e-48	176.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,1S25H@1236|Gammaproteobacteria,1WY0Q@135613|Chromatiales	135613|Chromatiales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD1_k127_7122212_0	572477.Alvin_0048	2.272e-169	543.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,1RNKE@1236|Gammaproteobacteria,1WWG8@135613|Chromatiales	135613|Chromatiales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transf_3
HKD1_k127_7122212_1	1170562.Cal6303_5638	7.934e-102	346.0	COG3464@1|root,COG3464@2|Bacteria,1G6BF@1117|Cyanobacteria	1117|Cyanobacteria	L	IMG reference gene	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7179789_1	1123368.AUIS01000019_gene1204	3.079e-108	356.0	COG2170@1|root,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,1RPKZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	glutamate--cysteine ligase	ybdK_1	-	-	-	-	-	-	-	-	-	-	-	GCS2
HKD1_k127_7179789_2	62928.azo0391	7.483e-37	144.0	COG0789@1|root,COG0789@2|Bacteria,1RITY@1224|Proteobacteria,2VSPA@28216|Betaproteobacteria,2KWYU@206389|Rhodocyclales	206389|Rhodocyclales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_7179789_0	1192034.CAP_2518	1.053e-152	493.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,42MY5@68525|delta/epsilon subdivisions,2WKST@28221|Deltaproteobacteria,2Z302@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_7180734_4	1519464.HY22_03645	1.763e-34	133.0	COG1274@1|root,COG1274@2|Bacteria,1FDFQ@1090|Chlorobi	1090|Chlorobi	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD1_k127_7180734_1	1026882.MAMP_02804	5.64e-141	462.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,45ZW3@72273|Thiotrichales	72273|Thiotrichales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_7180734_2	1121935.AQXX01000142_gene2183	1.147e-74	252.0	COG1592@1|root,COG1592@2|Bacteria,1R9WG@1224|Proteobacteria,1S25G@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_7180734_0	1049564.TevJSym_bd00260	5.529e-193	611.0	COG0247@1|root,COG0247@2|Bacteria,1MWTK@1224|Proteobacteria,1RQ9M@1236|Gammaproteobacteria,1J7KN@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Cysteine-rich domain	glpC	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006091,GO:0008150,GO:0008152,GO:0009061,GO:0009987,GO:0015980,GO:0016020,GO:0022900,GO:0043167,GO:0043169,GO:0044237,GO:0044464,GO:0045333,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0055114,GO:0071944	1.1.5.3	ko:K00113,ko:K11473	ko00564,ko00630,ko01100,ko01110,ko01120,ko01130,map00564,map00630,map01100,map01110,map01120,map01130	-	R00475,R00848	RC00029,RC00042	ko00000,ko00001,ko01000	-	-	-	CCG,Fer4_8
HKD1_k127_7180734_3	2340.JV46_02690	2.088e-69	240.0	COG0247@1|root,COG0247@2|Bacteria,1RF02@1224|Proteobacteria,1S302@1236|Gammaproteobacteria,1J9N9@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Protein of unknown function (DUF3501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3501
HKD1_k127_7192937_1	765912.Thimo_2796	4.33e-60	211.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD1_k127_7192937_0	105559.Nwat_2725	0.0	1521.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,1RN6C@1236|Gammaproteobacteria,1WX1Z@135613|Chromatiales	135613|Chromatiales	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HKD1_k127_7227291_3	179408.Osc7112_0731	3.267e-92	310.0	COG4636@1|root,COG4636@2|Bacteria,1G0MY@1117|Cyanobacteria,1H9BQ@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DUF4351,Uma2
HKD1_k127_7227291_0	56110.Oscil6304_4493	0.0	1226.0	COG0553@1|root,COG0553@2|Bacteria,1G0S7@1117|Cyanobacteria,1H7YD@1150|Oscillatoriales	1117|Cyanobacteria	L	SNF2 family N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3670,Helicase_C,SNF2_N
HKD1_k127_7227291_1	82654.Pse7367_3821	2.078e-102	340.0	COG4279@1|root,COG4279@2|Bacteria,1G2MZ@1117|Cyanobacteria,1HH53@1150|Oscillatoriales	1117|Cyanobacteria	S	Swim zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	SWIM
HKD1_k127_7227291_4	580332.Slit_0716	8.97e-44	165.0	COG0454@1|root,COG0456@2|Bacteria,1NCNY@1224|Proteobacteria	1224|Proteobacteria	K	PFAM GCN5-related N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_7227291_2	335543.Sfum_0601	1.435e-96	327.0	COG0726@1|root,COG0726@2|Bacteria,1R8KN@1224|Proteobacteria,43AMI@68525|delta/epsilon subdivisions,2X61I@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_722957_2	395493.BegalDRAFT_2685	2.983e-66	232.0	COG1459@1|root,COG1459@2|Bacteria,1MV4U@1224|Proteobacteria,1RQ86@1236|Gammaproteobacteria,45ZS7@72273|Thiotrichales	72273|Thiotrichales	NU	TIGRFAM general secretion pathway protein F	-	-	-	ko:K02455	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSF
HKD1_k127_722957_3	1123236.KB899377_gene191	5.337e-22	96.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,464D8@72275|Alteromonadaceae	1236|Gammaproteobacteria	NU	COG2804 Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB	gspE	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD1_k127_722957_0	765914.ThisiDRAFT_1295	1.991e-183	582.0	COG2804@1|root,COG2804@2|Bacteria,1MU7V@1224|Proteobacteria,1RMBS@1236|Gammaproteobacteria,1WX5F@135613|Chromatiales	135613|Chromatiales	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD1_k127_722957_1	391615.ABSJ01000050_gene1178	2.023e-157	522.0	COG1450@1|root,COG1450@2|Bacteria,1MUUA@1224|Proteobacteria,1RPJS@1236|Gammaproteobacteria,1J7Q2@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	NU	Bacterial type II and III secretion system protein	gspD	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Secretin,Secretin_N
HKD1_k127_7276066_4	518766.Rmar_2470	1.099e-45	169.0	COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes	976|Bacteroidetes	V	Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
HKD1_k127_7276066_0	519989.ECTPHS_04990	3.642e-270	839.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,1RMTC@1236|Gammaproteobacteria,1WWE3@135613|Chromatiales	135613|Chromatiales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_7276066_2	269796.Rru_A1069	1.321e-109	360.0	COG2000@1|root,COG2000@2|Bacteria,1NU4F@1224|Proteobacteria	1224|Proteobacteria	C	Putative Fe-S cluster	-	-	-	-	-	-	-	-	-	-	-	-	FeS
HKD1_k127_7276066_5	269796.Rru_A1068	2.217e-34	139.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JPHR@204441|Rhodospirillales	204441|Rhodospirillales	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_7276066_1	316067.Geob_2525	2.063e-122	399.0	COG0378@1|root,COG0378@2|Bacteria,1PXCI@1224|Proteobacteria,42MSU@68525|delta/epsilon subdivisions,2WISA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KO	PFAM cobalamin synthesis protein P47K	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD1_k127_7276066_7	593750.Metfor_0733	1.801e-09	63.0	COG1136@1|root,arCOG03228@2157|Archaea,2XVM5@28890|Euryarchaeota,2N9ID@224756|Methanomicrobia	224756|Methanomicrobia	E	PFAM ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_7276066_3	269796.Rru_A1066	8.22e-82	278.0	COG1136@1|root,COG1136@2|Bacteria,1PXKV@1224|Proteobacteria,2U2EP@28211|Alphaproteobacteria,2JWPD@204441|Rhodospirillales	204441|Rhodospirillales	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_7276066_6	316067.Geob_2523	1.539e-29	118.0	COG1959@1|root,COG1959@2|Bacteria	2|Bacteria	K	2 iron, 2 sulfur cluster binding	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HKD1_k127_7278382_3	634956.Geoth_0020	6.46e-79	273.0	COG3378@1|root,COG5519@1|root,COG3378@2|Bacteria,COG5519@2|Bacteria,1TQP9@1239|Firmicutes,4HBTB@91061|Bacilli	91061|Bacilli	L	Phage plasmid primase, P4	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	D5_N,Pox_D5
HKD1_k127_7278382_2	1183438.GKIL_0100	2.089e-80	274.0	COG1961@1|root,COG1961@2|Bacteria,1G67F@1117|Cyanobacteria	1117|Cyanobacteria	L	DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	HTH_7,Resolvase
HKD1_k127_7278382_0	1357275.AVEL02000148_gene3518	9.285e-243	761.0	COG2801@1|root,COG2801@2|Bacteria,1QWUR@1224|Proteobacteria,1T3Y1@1236|Gammaproteobacteria,1ZAFK@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_7278382_1	1197906.CAJQ02000056_gene3693	8.674e-91	309.0	COG3267@1|root,COG3267@2|Bacteria,1N4AU@1224|Proteobacteria	1224|Proteobacteria	U	Type II secretory pathway component ExeA	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HKD1_k127_7278553_6	28444.JODQ01000006_gene318	9.387e-58	214.0	COG1501@1|root,COG1501@2|Bacteria,2GP4V@201174|Actinobacteria,4EGGU@85012|Streptosporangiales	201174|Actinobacteria	G	Glycosyl hydrolases family 31	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	CBM_20,CBM_6,DUF5110,Glyco_hydro_31
HKD1_k127_7278553_8	1127673.GLIP_2048	5.559e-29	129.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1MVM7@1224|Proteobacteria,1RP2N@1236|Gammaproteobacteria,469C2@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Alpha amylase, catalytic domain	treZ	-	2.4.1.18,3.2.1.141	ko:K00700,ko:K01236	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110,R09995,R11256	RC00049	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,CBM_48,DUF3459
HKD1_k127_7278553_4	118161.KB235922_gene570	3.226e-69	242.0	COG3321@1|root,COG3321@2|Bacteria,1FZXE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Beta-ketoacyl synthase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N_2,Acyl_transf_1,KAsynt_C_assoc,KR,Ketoacyl-synt_C,PP-binding,PS-DH,Sulfotransfer_3,Thioesterase,ketoacyl-synt
HKD1_k127_7278553_5	1288494.EBAPG3_31080	2.646e-65	244.0	COG0367@1|root,COG0367@2|Bacteria,1N44T@1224|Proteobacteria,2W4WT@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	-
HKD1_k127_7278553_2	1288494.EBAPG3_31090	1.662e-84	302.0	COG0438@1|root,COG0438@2|Bacteria,1NPA5@1224|Proteobacteria,2W19T@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1
HKD1_k127_7278553_1	391625.PPSIR1_00475	1.211e-126	426.0	COG1524@1|root,COG1524@2|Bacteria	2|Bacteria	S	mannose-ethanolamine phosphotransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7278553_9	1134912.AJTV01000026_gene2679	3.268e-27	121.0	COG2091@1|root,COG2091@2|Bacteria,1MZHC@1224|Proteobacteria,2UFA4@28211|Alphaproteobacteria,36YVS@31993|Methylocystaceae	28211|Alphaproteobacteria	H	4'-phosphopantetheinyl transferase superfamily	MA20_09870	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_7278553_0	235985.BBPN01000001_gene1166	1.578e-147	479.0	COG0160@1|root,COG0160@2|Bacteria,2GKUY@201174|Actinobacteria,2NHSN@228398|Streptacidiphilus	201174|Actinobacteria	E	Aminotransferase class-III	-	-	2.6.1.76	ko:K00836	ko00260,ko01100,ko01120,ko01210,ko01230,map00260,map01100,map01120,map01210,map01230	M00033	R06977	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7278553_13	1458357.BG58_25850	6.165e-06	53.0	2BVWF@1|root,345UK@2|Bacteria,1P06N@1224|Proteobacteria,2W747@28216|Betaproteobacteria,1KDS7@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7278553_3	1038858.AXBA01000001_gene3145	1.072e-69	254.0	COG0330@1|root,COG0330@2|Bacteria,1RDFI@1224|Proteobacteria,2U1E0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_7278553_7	880073.Calab_2556	2.254e-30	124.0	COG3251@1|root,COG3251@2|Bacteria,2NRE2@2323|unclassified Bacteria	2|Bacteria	S	MbtH-like protein	-	-	-	ko:K05375,ko:K09190	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	MbtH,YqcI_YcgG
HKD1_k127_7278553_10	107636.JQNK01000006_gene930	1.257e-18	90.0	COG3316@1|root,COG5433@1|root,COG3316@2|Bacteria,COG5433@2|Bacteria,1MWZ2@1224|Proteobacteria,2U2PF@28211|Alphaproteobacteria,36ZM0@31993|Methylocystaceae	28211|Alphaproteobacteria	L	DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS240
HKD1_k127_7278553_11	105559.Nwat_2448	1.869e-16	81.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	tnp	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_7278553_12	105559.Nwat_2448	3.234e-10	61.0	COG3316@1|root,COG3316@2|Bacteria	2|Bacteria	-	-	tnp	-	-	ko:K07498	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS240
HKD1_k127_7284200_1	1316927.ATKI01000062_gene4197	1.867e-116	385.0	COG2038@1|root,COG2038@2|Bacteria,1MVAM@1224|Proteobacteria,1RNPV@1236|Gammaproteobacteria,1YQ26@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	F	Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)	cobT	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008939,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016757,GO:0016763,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.4.2.21	ko:K00768	ko00860,ko01100,map00860,map01100	M00122	R04148	RC00033,RC00063	ko00000,ko00001,ko00002,ko01000	-	-	iSDY_1059.SDY_2242,iSF_1195.SF2059,iSFxv_1172.SFxv_2293,iS_1188.S2169	DBI_PRT
HKD1_k127_7284200_5	1452718.JBOY01000092_gene2691	3.534e-62	220.0	COG2087@1|root,COG2087@2|Bacteria,1RH0A@1224|Proteobacteria,1S42M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate	cobU	GO:0003674,GO:0003824,GO:0006793,GO:0006796,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008819,GO:0008820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016779,GO:0033554,GO:0044237,GO:0050896,GO:0051716,GO:0070568	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	iECIAI1_1343.ECIAI1_2074,iECSE_1348.ECSE_2277,iECW_1372.ECW_m2165,iETEC_1333.ETEC_2103,iEcE24377_1341.EcE24377A_2275,iEcSMS35_1347.EcSMS35_1131,iEcolC_1368.EcolC_1635,iLF82_1304.LF82_0337,iSDY_1059.SDY_2240,iWFL_1372.ECW_m2165	CobU
HKD1_k127_7284200_2	768671.ThimaDRAFT_1808	1.005e-104	347.0	COG1122@1|root,COG1122@2|Bacteria,1N5X0@1224|Proteobacteria,1RRHF@1236|Gammaproteobacteria,1WZVE@135613|Chromatiales	135613|Chromatiales	P	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_7284200_4	768671.ThimaDRAFT_1807	6.813e-63	227.0	COG0619@1|root,COG0619@2|Bacteria,1R4KM@1224|Proteobacteria,1RQS9@1236|Gammaproteobacteria,1X145@135613|Chromatiales	135613|Chromatiales	P	Cobalt transport protein	-	-	-	-	-	-	-	-	-	-	-	-	CbiQ
HKD1_k127_7284200_7	1463909.KL585968_gene377	6.407e-25	107.0	COG1930@1|root,COG1930@2|Bacteria,2GRJ6@201174|Actinobacteria	201174|Actinobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiN	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	CbiN
HKD1_k127_7284200_3	768671.ThimaDRAFT_1805	2.757e-98	325.0	COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria,1RS8D@1236|Gammaproteobacteria,1X0PF@135613|Chromatiales	135613|Chromatiales	P	Cobalt uptake substrate-specific transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CbiM
HKD1_k127_7284200_8	640081.Dsui_2492	2.593e-05	48.0	COG1961@1|root,COG1961@2|Bacteria,1MXXT@1224|Proteobacteria,2VK5K@28216|Betaproteobacteria	28216|Betaproteobacteria	L	PFAM Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
HKD1_k127_7284200_6	443144.GM21_1874	5.893e-28	121.0	COG0394@1|root,COG0394@2|Bacteria,1MWYQ@1224|Proteobacteria,42SQK@68525|delta/epsilon subdivisions,2WPK1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM Protein-tyrosine phosphatase, low molecular weight	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_7284200_0	414684.RC1_3347	1.037e-288	906.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2JPT2@204441|Rhodospirillales	204441|Rhodospirillales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_7293340_19	1158756.AQXQ01000012_gene1350	2.374e-91	303.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,1RMXZ@1236|Gammaproteobacteria,1WW8H@135613|Chromatiales	135613|Chromatiales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD1_k127_7293340_6	1163617.SCD_n01129	5.181e-205	648.0	COG0498@1|root,COG0498@2|Bacteria,1MUWQ@1224|Proteobacteria,2VHR6@28216|Betaproteobacteria	28216|Betaproteobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD1_k127_7293340_0	1469245.JFBG01000077_gene318	0.0	1245.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,1RN5I@1236|Gammaproteobacteria,1WW6D@135613|Chromatiales	135613|Chromatiales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_7293340_26	1499967.BAYZ01000103_gene3776	4.617e-13	76.0	COG1100@1|root,COG1262@1|root,COG2319@1|root,COG1100@2|Bacteria,COG1262@2|Bacteria,COG2319@2|Bacteria,2NREY@2323|unclassified Bacteria	2|Bacteria	M	Anaphase-promoting complex subunit 4 WD40 domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PD40,Ras,TIR_2,WD40
HKD1_k127_7293340_25	1294273.roselon_01713	2.551e-18	89.0	COG2916@1|root,COG2916@2|Bacteria,1N801@1224|Proteobacteria,2UF4Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	DNA-binding protein, H-NS	hvrA	-	-	ko:K03746	-	-	-	-	ko00000,ko03036,ko03400	-	-	-	Histone_HNS
HKD1_k127_7293340_29	435842.HMPREF0848_00580	5.941e-05	48.0	COG0860@1|root,COG0860@2|Bacteria	2|Bacteria	M	N-Acetylmuramoyl-L-alanine amidase	lytC	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3,CW_binding_2,GBS_Bsp-like,SH3_3
HKD1_k127_7293340_24	648757.Rvan_1243	5.654e-43	164.0	COG0860@1|root,COG0860@2|Bacteria,1RJBG@1224|Proteobacteria,2TVMH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
HKD1_k127_7293340_22	1121935.AQXX01000092_gene3378	1.472e-68	241.0	COG1426@1|root,COG1426@2|Bacteria,1RIIX@1224|Proteobacteria,1S62E@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7293340_2	395493.BegalDRAFT_1084	7.29e-286	889.0	COG0129@1|root,COG0129@2|Bacteria,1MUTQ@1224|Proteobacteria,1RMP2@1236|Gammaproteobacteria,4608Q@72273|Thiotrichales	72273|Thiotrichales	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_7293340_9	1121396.KB893024_gene3899	7.129e-168	534.0	COG0399@1|root,COG0399@2|Bacteria,1MUPN@1224|Proteobacteria,42MTX@68525|delta/epsilon subdivisions,2WITE@28221|Deltaproteobacteria,2MIIQ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Belongs to the DegT DnrJ EryC1 family	arnB	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_7293340_14	1121403.AUCV01000015_gene4716	4.331e-126	410.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42NYX@68525|delta/epsilon subdivisions,2WJV8@28221|Deltaproteobacteria,2MN5W@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase like family 2	arnC	-	2.4.2.53	ko:K10012,ko:K20534	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8,4.D.2.1.9	GT2	-	Glycos_transf_2
HKD1_k127_7293340_1	1121396.KB893024_gene3901	5.695e-292	909.0	COG0223@1|root,COG0451@1|root,COG0223@2|Bacteria,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,42QC6@68525|delta/epsilon subdivisions,2WIRV@28221|Deltaproteobacteria,2MMI1@213118|Desulfobacterales	28221|Deltaproteobacteria	GJM	Formyl transferase, C-terminal domain	arnA	-	1.1.1.305,2.1.2.13	ko:K10011,ko:K12449	ko00520,ko01100,ko01503,map00520,map01100,map01503	M00721,M00761	R01384,R01386,R07658,R07660	RC00026,RC00508,RC01575,RC01811,RC01812	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase,Formyl_trans_C,Formyl_trans_N
HKD1_k127_7293340_16	1121403.AUCV01000015_gene4718	1.979e-113	373.0	COG0726@1|root,COG0726@2|Bacteria,1N8Q4@1224|Proteobacteria,42RRH@68525|delta/epsilon subdivisions,2WNID@28221|Deltaproteobacteria,2MMUU@213118|Desulfobacterales	28221|Deltaproteobacteria	G	Polysaccharide deacetylase	arnD	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0882	Polysacc_deac_1
HKD1_k127_7293340_13	1121396.KB893024_gene3903	8.949e-129	430.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,2MM2H@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_7293340_11	1266925.JHVX01000001_gene2483	1.127e-149	481.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2WAY9@28216|Betaproteobacteria,371NX@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD1_k127_7293340_28	383372.Rcas_1746	2.354e-05	48.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	3.2.1.14,3.2.1.4	ko:K01179,ko:K01183	ko00500,ko00520,ko01100,map00500,map00520,map01100	-	R01206,R02334,R06200,R11307,R11308	RC00467	ko00000,ko00001,ko01000	-	GH18,GH5,GH9	-	Lipase_GDSL_2
HKD1_k127_7293340_17	1156937.MFUM_40010	3.865e-111	372.0	COG0297@1|root,COG0297@2|Bacteria,46Z3D@74201|Verrucomicrobia,37H6N@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_7293340_21	102129.Lepto7375DRAFT_0836	1.039e-68	245.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9	ko:K00845,ko:K13967,ko:K19979,ko:K20433	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko00525,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map00525,map01100,map01110,map01120,map01130,map01200	M00001,M00549,M00814,M00815	R00299,R01600,R01786,R02087,R02705,R11185,R11234	RC00002,RC00017,RC00290	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_7293340_23	102129.Lepto7375DRAFT_0836	1.516e-60	240.0	COG1940@1|root,COG1940@2|Bacteria	2|Bacteria	GK	ROK family	-	-	2.7.1.188,2.7.1.2,2.7.1.214,2.7.1.60,5.1.3.9	ko:K00845,ko:K13967,ko:K19979,ko:K20433	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko00525,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map00525,map01100,map01110,map01120,map01130,map01200	M00001,M00549,M00814,M00815	R00299,R01600,R01786,R02087,R02705,R11185,R11234	RC00002,RC00017,RC00290	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_7293340_15	396588.Tgr7_1549	1.011e-125	412.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,1RNDX@1236|Gammaproteobacteria,1WW21@135613|Chromatiales	135613|Chromatiales	M	UTP-glucose-1-phosphate uridylyltransferase	-	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_7293340_3	420324.KI912025_gene65	1.27e-243	766.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,1JUA7@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	alpha beta hydrolase fold	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	PHBC_N,PhaC_N
HKD1_k127_7293340_10	366602.Caul_1955	1.968e-159	516.0	COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,2TQYT@28211|Alphaproteobacteria,2KI10@204458|Caulobacterales	204458|Caulobacterales	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.19,2.3.1.8	ko:K00625,ko:K00634	ko00430,ko00620,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00650,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921,R01174	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HKD1_k127_7293340_20	349521.HCH_02409	1.629e-73	252.0	COG1898@1|root,COG1898@2|Bacteria,1R9YD@1224|Proteobacteria,1S245@1236|Gammaproteobacteria,1XJV6@135619|Oceanospirillales	135619|Oceanospirillales	M	Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4- hexulose	-	-	5.1.3.13	ko:K01790	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R06514	RC01531	ko00000,ko00001,ko00002,ko01000	-	-	-	dTDP_sugar_isom
HKD1_k127_7293340_18	933262.AXAM01000047_gene2339	1.635e-96	325.0	COG1091@1|root,COG1091@2|Bacteria,1MUXM@1224|Proteobacteria,42MGE@68525|delta/epsilon subdivisions,2WKQ9@28221|Deltaproteobacteria,2MJZG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	rmlD	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD1_k127_7293340_12	402881.Plav_2894	2.221e-135	436.0	COG2084@1|root,COG2084@2|Bacteria,1MUGU@1224|Proteobacteria,2TT50@28211|Alphaproteobacteria,1JNGY@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	MA20_25935	-	1.1.1.31,1.1.1.60	ko:K00020,ko:K00042	ko00280,ko00630,ko01100,map00280,map00630,map01100	-	R01745,R01747,R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_7293340_5	768671.ThimaDRAFT_2998	3.392e-205	655.0	COG0426@1|root,COG2199@1|root,COG0426@2|Bacteria,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,1WXES@135613|Chromatiales	135613|Chromatiales	CT	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD1_k127_7293340_27	396588.Tgr7_3248	3.851e-12	67.0	COG0084@1|root,COG0084@2|Bacteria,1MW5C@1224|Proteobacteria,1RP5T@1236|Gammaproteobacteria,1WWHE@135613|Chromatiales	135613|Chromatiales	L	hydrolase, TatD family	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_7293340_4	472759.Nhal_3283	3.862e-220	691.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,1RMVW@1236|Gammaproteobacteria,1WX6X@135613|Chromatiales	135613|Chromatiales	C	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_7293340_8	395493.BegalDRAFT_3280	3.6e-192	612.0	COG0836@1|root,COG0836@2|Bacteria,1MV39@1224|Proteobacteria,1RNQI@1236|Gammaproteobacteria,45ZVI@72273|Thiotrichales	72273|Thiotrichales	GM	Belongs to the mannose-6-phosphate isomerase type 2 family	-	-	2.7.7.13	ko:K00971	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD1_k127_7293340_7	338963.Pcar_1779	1.056e-197	627.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,42MET@68525|delta/epsilon subdivisions,2WITH@28221|Deltaproteobacteria,43T96@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Phosphoglucomutase/phosphomannomutase, C-terminal domain	algC	-	5.4.2.2,5.4.2.8	ko:K01840,ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_7298792_0	211165.AJLN01000125_gene5480	1.331e-199	637.0	COG0659@1|root,COG0659@2|Bacteria,1G0NU@1117|Cyanobacteria,1JJ5V@1189|Stigonemataceae	1117|Cyanobacteria	P	Sulfate permease family	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD1_k127_7298792_3	1034943.BN1094_00473	5.657e-15	81.0	2E34D@1|root,32Y4G@2|Bacteria,1NBBC@1224|Proteobacteria,1SH1A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non- specifically the aggregation of denaturated periplasmic proteins	hdeA	GO:0003674,GO:0005488,GO:0005515,GO:0008150,GO:0009268,GO:0009628,GO:0009987,GO:0010447,GO:0042802,GO:0050896,GO:0051087,GO:0051716,GO:0071214,GO:0071467,GO:0071468,GO:0104004	-	ko:K19777	-	-	-	-	ko00000,ko03110	-	-	-	HdeA
HKD1_k127_7298792_5	857087.Metme_3588	6.044e-08	61.0	2BZSH@1|root,31Q3W@2|Bacteria,1QMSI@1224|Proteobacteria,1TK2C@1236|Gammaproteobacteria,1XFYG@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7298792_1	1049564.TevJSym_as00710	2.722e-149	484.0	COG0373@1|root,COG0373@2|Bacteria,1MU41@1224|Proteobacteria,1RNQ8@1236|Gammaproteobacteria,1J5GP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006082,GO:0006520,GO:0006536,GO:0006725,GO:0006778,GO:0006779,GO:0006782,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0008883,GO:0009058,GO:0009064,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0018130,GO:0019353,GO:0019438,GO:0019752,GO:0033013,GO:0033014,GO:0033526,GO:0034641,GO:0042168,GO:0042440,GO:0042802,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046148,GO:0046483,GO:0046501,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	iECNA114_1301.ECNA114_1375,iECSF_1327.ECSF_1186,iUTI89_1310.UTI89_C1404	GlutR_N,GlutR_dimer,Shikimate_DH
HKD1_k127_7298792_2	396588.Tgr7_0524	1.9e-110	379.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,1RQIX@1236|Gammaproteobacteria,1WWY6@135613|Chromatiales	135613|Chromatiales	U	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HKD1_k127_7298792_4	1122194.AUHU01000013_gene676	2.913e-09	62.0	COG3017@1|root,COG3017@2|Bacteria,1N02T@1224|Proteobacteria,1S91E@1236|Gammaproteobacteria,468AP@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein	lolB	GO:0003674,GO:0005488,GO:0005575,GO:0005623,GO:0006807,GO:0008104,GO:0008150,GO:0008152,GO:0008289,GO:0009279,GO:0010876,GO:0016020,GO:0019538,GO:0019867,GO:0030312,GO:0030313,GO:0031975,GO:0033036,GO:0033218,GO:0034613,GO:0042157,GO:0042277,GO:0043170,GO:0044238,GO:0044462,GO:0044464,GO:0044872,GO:0044873,GO:0044874,GO:0051179,GO:0051641,GO:0051668,GO:0070727,GO:0071704,GO:0071723,GO:0071944,GO:0072657,GO:1901564	-	ko:K02494	-	-	-	-	ko00000	-	-	-	LolB
HKD1_k127_7319663_8	338966.Ppro_1649	2.745e-14	76.0	COG3064@1|root,COG3666@1|root,COG3064@2|Bacteria,COG3666@2|Bacteria,1N3QR@1224|Proteobacteria,42R6X@68525|delta/epsilon subdivisions,2WMY9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_7319663_4	713586.KB900536_gene189	2.366e-50	181.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,1S3QE@1236|Gammaproteobacteria,1WYPB@135613|Chromatiales	135613|Chromatiales	FG	PFAM Histidine triad (HIT) protein	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	DcpS_C,HIT
HKD1_k127_7319663_2	187272.Mlg_1508	7.3e-91	304.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,1RN99@1236|Gammaproteobacteria,1WY1A@135613|Chromatiales	135613|Chromatiales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HKD1_k127_7319663_7	391615.ABSJ01000002_gene494	1.101e-35	140.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,1S5WU@1236|Gammaproteobacteria,1J6QE@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	ybaB	GO:0003674,GO:0003676,GO:0003677,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464,GO:0097159,GO:1901363	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD1_k127_7319663_0	396588.Tgr7_1073	1.942e-169	550.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,1RMIA@1236|Gammaproteobacteria,1WX0K@135613|Chromatiales	135613|Chromatiales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DNA_pol3_tau_5
HKD1_k127_7319663_10	637390.AFOH01000083_gene2563	4.084e-07	53.0	2AQHB@1|root,31FPW@2|Bacteria,1QDD4@1224|Proteobacteria,1T9B5@1236|Gammaproteobacteria,2NE4I@225057|Acidithiobacillales	225057|Acidithiobacillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7319663_1	1158292.JPOE01000005_gene216	1.157e-167	537.0	COG0277@1|root,COG0277@2|Bacteria,1N4UQ@1224|Proteobacteria,2W1U4@28216|Betaproteobacteria	28216|Betaproteobacteria	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4
HKD1_k127_7319663_5	497321.C664_09768	1.444e-39	150.0	COG3094@1|root,COG3094@2|Bacteria,1MZN6@1224|Proteobacteria,2VUWN@28216|Betaproteobacteria,2KWZ1@206389|Rhodocyclales	206389|Rhodocyclales	S	Invasion gene expression up-regulator SirB	sirB	-	-	-	-	-	-	-	-	-	-	-	SirB
HKD1_k127_7319663_3	402881.Plav_0305	8.065e-90	312.0	COG0642@1|root,COG0642@2|Bacteria,1QYPP@1224|Proteobacteria,2TXUU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD1_k127_7319663_6	768671.ThimaDRAFT_1817	1.244e-36	142.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1X0JA@135613|Chromatiales	135613|Chromatiales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_7336868_4	572477.Alvin_0230	8.218e-73	254.0	COG1819@1|root,COG1819@2|Bacteria,1MVJM@1224|Proteobacteria,1S4AQ@1236|Gammaproteobacteria,1WW8B@135613|Chromatiales	135613|Chromatiales	CG	glycosyl	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7336868_2	1123487.KB892834_gene2720	6.156e-100	333.0	COG1122@1|root,COG1122@2|Bacteria,1QWP9@1224|Proteobacteria	1224|Proteobacteria	P	Pfam ABC transporter related	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran,DUF3744
HKD1_k127_7336868_5	525904.Tter_0883	8.989e-73	254.0	COG0619@1|root,COG0619@2|Bacteria,2NRVG@2323|unclassified Bacteria	2|Bacteria	P	PFAM Cobalt transport protein	cbiQ	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015675,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02007,ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD1_k127_7336868_1	1122963.AUHB01000016_gene4361	9.61e-144	464.0	COG0310@1|root,COG0310@2|Bacteria,1NTQK@1224|Proteobacteria,2U0RQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	GO:0000041,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006824,GO:0008150,GO:0016020,GO:0016021,GO:0030001,GO:0031224,GO:0032991,GO:0043190,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0071944,GO:0072511,GO:0098533,GO:0098796,GO:0098797,GO:1902494,GO:1902495,GO:1904949,GO:1990351	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
HKD1_k127_7336868_7	32057.KB217483_gene8825	2.28e-05	50.0	28SKK@1|root,2ZEWX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7336868_6	221288.JH992901_gene2884	6.652e-71	241.0	COG1961@1|root,COG1961@2|Bacteria,1G266@1117|Cyanobacteria,1JKFH@1189|Stigonemataceae	1117|Cyanobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_7336868_0	1123368.AUIS01000006_gene566	1.931e-149	505.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,1RM8A@1236|Gammaproteobacteria,2NDJD@225057|Acidithiobacillales	225057|Acidithiobacillales	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_4,Response_reg
HKD1_k127_7336868_3	1137799.GZ78_22890	1.635e-95	318.0	COG0583@1|root,COG0583@2|Bacteria,1MU8N@1224|Proteobacteria,1RN7T@1236|Gammaproteobacteria,1XHD6@135619|Oceanospirillales	135619|Oceanospirillales	K	in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon	cysB	-	-	ko:K13634	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_7350116_1	338966.Ppro_0396	1.436e-103	344.0	COG2304@1|root,COG2885@1|root,COG2304@2|Bacteria,COG2885@2|Bacteria,1N20X@1224|Proteobacteria	1224|Proteobacteria	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_7350116_3	909663.KI867149_gene3372	2.941e-48	179.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WN8Y@28221|Deltaproteobacteria,2MQJ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_7350116_4	335543.Sfum_1481	2.977e-18	89.0	2DRBR@1|root,33B4T@2|Bacteria,1NHJT@1224|Proteobacteria,43EE5@68525|delta/epsilon subdivisions,2WSXG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
HKD1_k127_7350116_0	338966.Ppro_0405	2.511e-110	369.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,43T7X@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_7350116_2	1173024.KI912149_gene6519	1.437e-48	189.0	COG4191@1|root,COG4191@2|Bacteria,1G94J@1117|Cyanobacteria	1117|Cyanobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,dCache_1
HKD1_k127_7391355_12	1080067.BAZH01000017_gene562	2.413e-43	160.0	COG0683@1|root,COG0683@2|Bacteria,1MU8V@1224|Proteobacteria,1RMIJ@1236|Gammaproteobacteria,3WX4C@544|Citrobacter	1236|Gammaproteobacteria	E	Periplasmic binding protein domain	urtA	-	-	ko:K11959	ko02010,map02010	M00323	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4.4,3.A.1.4.5	-	-	Peripla_BP_5
HKD1_k127_7391355_5	29581.BW37_01645	3.938e-99	329.0	COG2267@1|root,COG2267@2|Bacteria,1NK3M@1224|Proteobacteria,2VKPD@28216|Betaproteobacteria,474PY@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_7391355_4	857087.Metme_2545	6.792e-106	346.0	COG0378@1|root,COG0378@2|Bacteria,1MVBD@1224|Proteobacteria,1RP5R@1236|Gammaproteobacteria,1XDUE@135618|Methylococcales	135618|Methylococcales	KO	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG	ureG	-	-	ko:K03189	-	-	-	-	ko00000	-	-	-	cobW
HKD1_k127_7391355_8	1125863.JAFN01000001_gene3215	7.271e-80	273.0	COG0830@1|root,COG0830@2|Bacteria,1MW8Q@1224|Proteobacteria,42VY4@68525|delta/epsilon subdivisions,2WS0F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureF	-	-	ko:K03188	-	-	-	-	ko00000	-	-	-	UreF
HKD1_k127_7391355_0	349521.HCH_04523	1.115e-314	970.0	COG0804@1|root,COG0804@2|Bacteria,1MU5P@1224|Proteobacteria,1RN78@1236|Gammaproteobacteria,1XHPP@135619|Oceanospirillales	135619|Oceanospirillales	E	Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family	ureC	-	3.5.1.5	ko:K01428	ko00220,ko00230,ko00791,ko01100,ko01120,ko05120,map00220,map00230,map00791,map01100,map01120,map05120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Urease_alpha
HKD1_k127_7391355_10	1301098.PKB_5185	5.489e-46	168.0	COG0832@1|root,COG0832@2|Bacteria,1RGW0@1224|Proteobacteria,1S8UP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	Belongs to the urease beta subunit family	ureB	GO:0003674,GO:0003824,GO:0006807,GO:0008150,GO:0008152,GO:0009039,GO:0016787,GO:0016810,GO:0016811	3.5.1.5	ko:K01429	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	iECH74115_1262.ECH74115_1322,iECO103_1326.ECO103_3798,iECO111_1330.ECO111_1228,iECSP_1301.ECSP_1250,iECs_1301.ECs1323,iUMNK88_1353.UMNK88_1200,iZ_1308.Z1144,iZ_1308.Z1583	Urease_beta
HKD1_k127_7391355_9	313612.L8106_28586	1.102e-47	172.0	COG0831@1|root,COG0831@2|Bacteria,1G6KQ@1117|Cyanobacteria,1HBG1@1150|Oscillatoriales	1117|Cyanobacteria	E	Belongs to the urease gamma subunit family	ureA	-	3.5.1.5	ko:K01430	ko00220,ko00230,ko00791,ko01100,ko01120,map00220,map00230,map00791,map01100,map01120	-	R00131	RC02798,RC02806	ko00000,ko00001,ko01000	-	-	-	Urease_gamma
HKD1_k127_7391355_7	1125863.JAFN01000001_gene3220	2.623e-82	282.0	COG0829@1|root,COG0829@2|Bacteria,1RABD@1224|Proteobacteria,42RZJ@68525|delta/epsilon subdivisions,2X6U6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Required for maturation of urease via the functional incorporation of the urease nickel metallocenter	ureD	-	-	ko:K03190	-	-	-	-	ko00000	-	-	-	UreD
HKD1_k127_7391355_14	102125.Xen7305DRAFT_00049030	4.96e-22	98.0	28WCA@1|root,2ZICN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7391355_3	264730.PSPPH_2358	1.108e-121	394.0	COG4870@1|root,COG4870@2|Bacteria,1MV6S@1224|Proteobacteria,1S02V@1236|Gammaproteobacteria,1Z6BR@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	O	Papain cysteine protease family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C1
HKD1_k127_7391355_2	269799.Gmet_3221	1.805e-170	544.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,43CB2@68525|delta/epsilon subdivisions,2X7MH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7391355_13	1230457.C476_11523	2.184e-22	100.0	COG1752@1|root,arCOG09020@2157|Archaea,2XV1A@28890|Euryarchaeota,23S0S@183963|Halobacteria	2157|Archaea	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_7391355_11	1380393.JHVP01000001_gene2338	1.525e-44	171.0	COG1752@1|root,COG1752@2|Bacteria,2IDUX@201174|Actinobacteria,4EUXC@85013|Frankiales	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_7391355_6	696747.NIES39_D01750	6.145e-86	296.0	COG4636@1|root,COG4636@2|Bacteria,1FZYR@1117|Cyanobacteria,1H7TI@1150|Oscillatoriales	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_7391355_1	313624.NSP_22650	1.215e-305	949.0	COG0553@1|root,COG0553@2|Bacteria,1G2YQ@1117|Cyanobacteria,1HME5@1161|Nostocales	1117|Cyanobacteria	L	Superfamily II DNA RNA helicase, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
HKD1_k127_7409656_1	266264.Rmet_1377	1.465e-122	400.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,1K08X@119060|Burkholderiaceae	28216|Betaproteobacteria	P	sulfate ABC transporter	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD1_k127_7409656_0	1120999.JONM01000028_gene182	2.513e-145	469.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2VH92@28216|Betaproteobacteria,2KQ5Y@206351|Neisseriales	206351|Neisseriales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_3
HKD1_k127_7409656_3	713586.KB900536_gene2508	2.608e-104	347.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,1RNS7@1236|Gammaproteobacteria,1WXE7@135613|Chromatiales	135613|Chromatiales	GM	NAD-dependent epimerase dehydratase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Epimerase,NAD_binding_10
HKD1_k127_7409656_2	1235457.C404_19045	7.069e-108	370.0	COG4324@1|root,COG4324@2|Bacteria,1N0FE@1224|Proteobacteria,2VH73@28216|Betaproteobacteria,1K6J1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	zinc protease protein	-	-	-	-	-	-	-	-	-	-	-	-	Aminopep
HKD1_k127_7409656_4	519989.ECTPHS_02124	5.314e-84	281.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_7411021_6	1211114.ALIP01000040_gene2936	5.874e-20	96.0	COG1399@1|root,COG1399@2|Bacteria,1PSXM@1224|Proteobacteria,1SWVC@1236|Gammaproteobacteria,1X6K9@135614|Xanthomonadales	135614|Xanthomonadales	S	ACR protein	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD1_k127_7411021_5	1121943.KB899994_gene980	3.75e-20	93.0	COG0333@1|root,COG0333@2|Bacteria,1N6RF@1224|Proteobacteria,1SC9G@1236|Gammaproteobacteria,1XM5T@135619|Oceanospirillales	135619|Oceanospirillales	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_7411021_1	519989.ECTPHS_10366	1.428e-133	435.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,1RM7R@1236|Gammaproteobacteria,1WW6R@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD1_k127_7411021_0	323261.Noc_1667	8.086e-142	457.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,1RNIR@1236|Gammaproteobacteria,1WWWT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_7411021_2	2340.JV46_14770	2.225e-100	332.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,1RMBB@1236|Gammaproteobacteria,1J4H7@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	GO:0000166,GO:0003674,GO:0003824,GO:0004312,GO:0004316,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0030497,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051188,GO:0055114,GO:0071704,GO:0072330,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iAF1260.b1093,iAPECO1_1312.APECO1_174,iBWG_1329.BWG_0941,iE2348C_1286.E2348C_1185,iEC55989_1330.EC55989_1205,iECABU_c1320.ECABU_c13060,iECDH10B_1368.ECDH10B_1165,iECDH1ME8569_1439.ECDH1ME8569_1028,iECED1_1282.ECED1_1236,iECIAI39_1322.ECIAI39_2068,iECNA114_1301.ECNA114_1150,iECO103_1326.ECO103_1138,iECOK1_1307.ECOK1_1200,iECP_1309.ECP_1085,iECS88_1305.ECS88_1107,iECSE_1348.ECSE_1157,iECSF_1327.ECSF_0992,iECUMN_1333.ECUMN_1268,iECW_1372.ECW_m1201,iEKO11_1354.EKO11_2741,iETEC_1333.ETEC_1158,iEcDH1_1363.EcDH1_2554,iEcE24377_1341.EcE24377A_1214,iEcHS_1320.EcHS_A1215,iEcSMS35_1347.EcSMS35_2034,iEcolC_1368.EcolC_2508,iG2583_1286.G2583_1353,iJN746.PP_1914,iJO1366.b1093,iJR904.b1093,iSBO_1134.SBO_1970,iSFV_1184.SFV_1113,iSF_1195.SF1097,iSFxv_1172.SFxv_1249,iSSON_1240.SSON_1113,iS_1188.S1177,iSbBS512_1146.SbBS512_E2231,iUMN146_1321.UM146_11860,iUMNK88_1353.UMNK88_1363,iUTI89_1310.UTI89_C1218,iWFL_1372.ECW_m1201,iY75_1357.Y75_RS05710	adh_short_C2
HKD1_k127_7411021_4	935567.JAES01000030_gene2861	5.214e-34	132.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,1S8X4@1236|Gammaproteobacteria,1X7EF@135614|Xanthomonadales	135614|Xanthomonadales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_7411021_3	754476.Q7A_2012	3.95e-84	283.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,1RMDE@1236|Gammaproteobacteria,45ZQ6@72273|Thiotrichales	72273|Thiotrichales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_7418302_18	1499967.BAYZ01000076_gene762	9.881e-07	50.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35
HKD1_k127_7418302_0	768671.ThimaDRAFT_3893	0.0	1388.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,1RN6K@1236|Gammaproteobacteria,1WWE0@135613|Chromatiales	135613|Chromatiales	C	Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceE	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_7418302_3	1120999.JONM01000014_gene2870	1.82e-170	550.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2VIHA@28216|Betaproteobacteria,2KQE4@206351|Neisseriales	206351|Neisseriales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_7418302_7	460265.Mnod_7349	3.332e-71	251.0	COG0457@1|root,COG4249@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,1RKBA@1224|Proteobacteria,2TRAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_7418302_5	1198232.CYCME_0385	4.531e-72	248.0	COG0625@1|root,COG0625@2|Bacteria,1RAIN@1224|Proteobacteria,1S3Q5@1236|Gammaproteobacteria,462IB@72273|Thiotrichales	72273|Thiotrichales	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
HKD1_k127_7418302_1	105559.Nwat_1980	2.64e-231	722.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,1RMNB@1236|Gammaproteobacteria,1WWPY@135613|Chromatiales	135613|Chromatiales	I	TIGRFAM acetyl-CoA carboxylase, biotin carboxylase	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_7418302_9	1122139.KB907871_gene2322	1.903e-49	186.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,1S3YP@1236|Gammaproteobacteria,1XJMR@135619|Oceanospirillales	135619|Oceanospirillales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD1_k127_7418302_8	1278309.KB907110_gene3175	7.106e-59	208.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,1S3PX@1236|Gammaproteobacteria,1XJM2@135619|Oceanospirillales	135619|Oceanospirillales	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD1_k127_7418302_4	1487953.JMKF01000059_gene4938	2.037e-77	265.0	COG4636@1|root,COG4636@2|Bacteria,1G5GG@1117|Cyanobacteria,1HAK2@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_7418302_10	945713.IALB_2017	8.954e-33	132.0	COG2852@1|root,COG2852@2|Bacteria	2|Bacteria	L	Protein conserved in bacteria	-	-	2.1.1.72	ko:K03427,ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03400	-	-	-	DUF559
HKD1_k127_7418302_11	671143.DAMO_0151	4.604e-28	115.0	2E90H@1|root,3339X@2|Bacteria,2NS0Z@2323|unclassified Bacteria	2|Bacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7418302_17	671143.DAMO_0150	3.335e-09	57.0	2C1SS@1|root,32YN6@2|Bacteria,2NRN5@2323|unclassified Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7418302_13	65393.PCC7424_4683	1.418e-13	72.0	2C1SS@1|root,32YN6@2|Bacteria,1G9HK@1117|Cyanobacteria,3KKJV@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7418302_15	631362.Thi970DRAFT_04766	4.861e-12	68.0	COG1848@1|root,COG1848@2|Bacteria,1Q9A8@1224|Proteobacteria,1SPBZ@1236|Gammaproteobacteria,1X0SZ@135613|Chromatiales	135613|Chromatiales	S	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_7418302_14	713587.THITH_05595	1.445e-13	71.0	COG1848@1|root,COG1848@2|Bacteria,1Q9A8@1224|Proteobacteria,1SPBZ@1236|Gammaproteobacteria,1X0SZ@135613|Chromatiales	135613|Chromatiales	S	PIN domain	-	-	-	ko:K07064	-	-	-	-	ko00000	-	-	-	PIN
HKD1_k127_7418302_12	713587.THITH_05590	1.343e-19	90.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_7418302_16	649638.Trad_1397	5.372e-11	66.0	2EFYU@1|root,339R0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD1_k127_7418302_2	395494.Galf_0059	9.49e-220	693.0	COG0493@1|root,COG1144@1|root,COG0493@2|Bacteria,COG1144@2|Bacteria,1MU2H@1224|Proteobacteria,2VM9R@28216|Betaproteobacteria,44V9S@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Fer4_21,Pyr_redox_2,Pyr_redox_3
HKD1_k127_7418302_6	1027273.GZ77_15435	1.479e-71	244.0	COG1013@1|root,COG1013@2|Bacteria,1MUY9@1224|Proteobacteria,1S1PF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Pyruvate ferredoxin oxidoreductase	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_74316_1	522306.CAP2UW1_1789	7.879e-106	350.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2VM89@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD1_k127_74316_0	1223521.BBJX01000002_gene2860	1.868e-264	824.0	COG0843@1|root,COG0843@2|Bacteria,1R57U@1224|Proteobacteria,2VJ1N@28216|Betaproteobacteria,4AHFT@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM Cytochrome c oxidase, subunit I	cbaA	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_74316_2	596154.Alide2_3909	3.611e-86	290.0	COG1622@1|root,COG1622@2|Bacteria,1NZNI@1224|Proteobacteria,2VNRT@28216|Betaproteobacteria,4AGHP@80864|Comamonadaceae	28216|Betaproteobacteria	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HKD1_k127_74316_3	1123360.thalar_02883	8.88e-13	70.0	2ERCE@1|root,33IY3@2|Bacteria,1NNN9@1224|Proteobacteria,2UXY5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7434580_2	713586.KB900536_gene2181	3.441e-16	82.0	COG3159@1|root,COG3159@2|Bacteria,1R4BP@1224|Proteobacteria,1S9SC@1236|Gammaproteobacteria,1WY2X@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HKD1_k127_7434580_1	338963.Pcar_1723	5.395e-183	592.0	COG3083@1|root,COG3083@2|Bacteria	2|Bacteria	S	sulfuric ester hydrolase activity	yejM	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07014	-	-	-	-	ko00000	-	-	-	DUF3413,Sulfatase
HKD1_k127_7434580_0	1163408.UU9_10412	1.266e-185	595.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1MXH9@1224|Proteobacteria,1RPQ6@1236|Gammaproteobacteria,1X52G@135614|Xanthomonadales	135614|Xanthomonadales	S	membrane	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HKD1_k127_7447719_8	314278.NB231_17258	2.327e-50	183.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,1S47H@1236|Gammaproteobacteria,1WXYW@135613|Chromatiales	135613|Chromatiales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_7447719_10	472759.Nhal_2440	2.475e-33	134.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,1S98P@1236|Gammaproteobacteria,1WZIU@135613|Chromatiales	135613|Chromatiales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_7447719_3	472759.Nhal_2439	3.408e-100	333.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,1RMS5@1236|Gammaproteobacteria,1WXFG@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD1_k127_7447719_7	1123257.AUFV01000002_gene2423	3.202e-55	201.0	COG1381@1|root,COG1381@2|Bacteria,1RHIC@1224|Proteobacteria,1RN8Y@1236|Gammaproteobacteria,1X30R@135614|Xanthomonadales	135614|Xanthomonadales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD1_k127_7447719_2	322710.Avin_13790	1.132e-108	359.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,1RN3A@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009898,GO:0009987,GO:0016020,GO:0016310,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019538,GO:0019843,GO:0019897,GO:0019898,GO:0022613,GO:0031234,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0036211,GO:0042254,GO:0042274,GO:0043021,GO:0043024,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044425,GO:0044444,GO:0044459,GO:0044464,GO:0044877,GO:0046777,GO:0070181,GO:0071704,GO:0071840,GO:0071944,GO:0097159,GO:0097367,GO:0098552,GO:0098562,GO:1901265,GO:1901363,GO:1901564	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD1_k127_7447719_6	1122139.KB907872_gene2294	2.142e-66	233.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,1RN0C@1236|Gammaproteobacteria,1XHKG@135619|Oceanospirillales	135619|Oceanospirillales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD1_k127_7447719_12	1121013.P873_12730	1.366e-16	85.0	COG4969@1|root,COG4969@2|Bacteria,1N71K@1224|Proteobacteria,1SCYD@1236|Gammaproteobacteria,1X8J8@135614|Xanthomonadales	135614|Xanthomonadales	NU	Domain of unknown function (DUF4845)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4845
HKD1_k127_7447719_5	1396858.Q666_09950	1.323e-86	293.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,1RMHI@1236|Gammaproteobacteria,464B8@72275|Alteromonadaceae	1236|Gammaproteobacteria	U	Belongs to the peptidase S26 family	lepB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD1_k127_7447719_0	686340.Metal_1537	6.547e-300	930.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,1RPFB@1236|Gammaproteobacteria,1XE1C@135618|Methylococcales	135618|Methylococcales	J	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_7447719_9	323261.Noc_2464	7.918e-49	188.0	COG3026@1|root,COG3026@2|Bacteria,1MUQ8@1224|Proteobacteria,1RNF3@1236|Gammaproteobacteria,1WWVY@135613|Chromatiales	135613|Chromatiales	T	PFAM MucB RseB	-	-	-	ko:K03598	-	-	-	-	ko00000,ko03021	-	-	-	MucB_RseB,MucB_RseB_C
HKD1_k127_7447719_11	1049564.TevJSym_ah00310	1.161e-18	93.0	COG3073@1|root,COG3073@2|Bacteria,1N9FN@1224|Proteobacteria,1SWYJ@1236|Gammaproteobacteria,1J6IG@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	T	Anti sigma-E protein RseA, N-terminal domain	-	-	-	ko:K03597	-	-	-	-	ko00000,ko03021	-	-	-	RseA_N
HKD1_k127_7447719_4	472759.Nhal_0713	3.723e-89	298.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,1RN64@1236|Gammaproteobacteria,1WXBZ@135613|Chromatiales	135613|Chromatiales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_7447719_1	396588.Tgr7_1082	1.178e-250	784.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,1RMMD@1236|Gammaproteobacteria,1WWEZ@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	-	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_7447719_13	584708.Apau_0960	1.348e-14	77.0	COG2265@1|root,COG2265@2|Bacteria,3TAEF@508458|Synergistetes	508458|Synergistetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_U5-meth_tr
HKD1_k127_74592_3	522306.CAP2UW1_1523	6.647e-150	489.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2VI5V@28216|Betaproteobacteria,1KQSR@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT family	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_74592_1	306281.AJLK01000109_gene3145	1.67e-196	630.0	COG0367@1|root,COG0367@2|Bacteria,1G3S7@1117|Cyanobacteria	1117|Cyanobacteria	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_74592_9	399741.Spro_3858	9.07e-26	112.0	COG5265@1|root,COG5265@2|Bacteria,1NSKS@1224|Proteobacteria,1T1W9@1236|Gammaproteobacteria,401WG@613|Serratia	1236|Gammaproteobacteria	O	ABC transporter	atmA	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_74592_10	671143.DAMO_2421	1.908e-21	108.0	2C6B3@1|root,33P2S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_74592_8	1502852.FG94_02621	3.816e-36	152.0	COG1835@1|root,COG1835@2|Bacteria,1N3NP@1224|Proteobacteria,2WEEF@28216|Betaproteobacteria,4757B@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD1_k127_74592_4	1123399.AQVE01000001_gene575	7.476e-51	190.0	COG0586@1|root,COG0586@2|Bacteria,1MX4M@1224|Proteobacteria,1RPB1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	Pfam SNARE associated Golgi protein	VV0785	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_74592_6	909663.KI867149_gene3292	6.161e-43	160.0	COG1483@1|root,COG1483@2|Bacteria,1MX1G@1224|Proteobacteria,42VAG@68525|delta/epsilon subdivisions,2WREB@28221|Deltaproteobacteria,2MQVP@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF499)	-	-	-	ko:K06922	-	-	-	-	ko00000	-	-	-	DUF499
HKD1_k127_74592_2	1392838.AWNM01000078_gene1121	4.115e-171	550.0	COG3437@1|root,COG3437@2|Bacteria,1MUB8@1224|Proteobacteria,2VH1F@28216|Betaproteobacteria,3T8KQ@506|Alcaligenaceae	28216|Betaproteobacteria	T	HD domain	-	-	-	ko:K07814	-	-	-	-	ko00000,ko02022	-	-	-	HD,HD_5,Response_reg
HKD1_k127_74592_0	1244869.H261_16341	4.09e-254	845.0	COG0642@1|root,COG0784@1|root,COG2198@1|root,COG2202@1|root,COG2770@1|root,COG0784@2|Bacteria,COG2198@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG2770@2|Bacteria,1NRP8@1224|Proteobacteria,2TXJ2@28211|Alphaproteobacteria,2JPEA@204441|Rhodospirillales	204441|Rhodospirillales	T	Histidine kinase	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,Response_reg,dCache_1
HKD1_k127_74592_7	748247.AZKH_1671	4.668e-39	149.0	COG0845@1|root,COG0845@2|Bacteria,1PJHF@1224|Proteobacteria,2VIRN@28216|Betaproteobacteria	28216|Betaproteobacteria	M	TIGRFAM efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_3
HKD1_k127_7460502_5	76114.ebD116	9.167e-10	59.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_7460502_2	880072.Desac_2430	2.803e-58	213.0	COG4976@1|root,COG4976@2|Bacteria	2|Bacteria	O	Methyltransferase	cmoA	-	-	ko:K15256	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_23,Methyltransf_25,Methyltransf_31,NodS,PIG-L
HKD1_k127_7460502_4	324925.Ppha_1666	2.999e-10	63.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD1_k127_7460502_3	522306.CAP2UW1_0140	1.473e-46	174.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_7460502_6	324925.Ppha_2029	4.342e-05	49.0	COG5421@1|root,COG5421@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_2,DUF4096
HKD1_k127_7460502_1	1040986.ATYO01000012_gene5299	5.588e-67	234.0	COG1858@1|root,COG1858@2|Bacteria,1MV70@1224|Proteobacteria,2TRTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	cytochrome c peroxidase	-	-	1.11.1.5	ko:K00428	-	-	-	-	ko00000,ko01000	-	-	-	CCP_MauG,Cytochrom_C,Haem_bd
HKD1_k127_7460502_0	1040986.ATYO01000012_gene5298	1.85e-159	526.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2U235@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	histidine kinase A domain protein	virA	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,Response_reg
HKD1_k127_7468395_3	317619.ANKN01000039_gene61	1.33e-44	166.0	COG4636@1|root,COG4636@2|Bacteria,1GGUY@1117|Cyanobacteria	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7468395_1	1122201.AUAZ01000005_gene549	1.104e-269	839.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RPJW@1236|Gammaproteobacteria,465TS@72275|Alteromonadaceae	1236|Gammaproteobacteria	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_7468395_0	207954.MED92_06008	2.534e-281	874.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,1RPJW@1236|Gammaproteobacteria,1XH2B@135619|Oceanospirillales	135619|Oceanospirillales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_7468395_2	396588.Tgr7_0962	1.192e-64	224.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,1S3PT@1236|Gammaproteobacteria,1WX50@135613|Chromatiales	135613|Chromatiales	O	the 2 termini fold to resemble tRNA(Ala) and it encodes a tag peptide , a short internal open reading frame. During trans-translation Ala- aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_7479688_5	269796.Rru_A3168	3.03e-140	450.0	COG4239@1|root,COG4239@2|Bacteria,1MUM5@1224|Proteobacteria,2TR1Y@28211|Alphaproteobacteria,2JPAS@204441|Rhodospirillales	204441|Rhodospirillales	P	transport system, permease component	-	-	-	ko:K13895	ko02010,map02010	M00349	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.21,3.A.1.5.24	-	-	BPD_transp_1,OppC_N
HKD1_k127_7479688_4	1123368.AUIS01000006_gene588	6.302e-153	487.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,1RP7S@1236|Gammaproteobacteria,2NCP9@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD1_k127_7479688_18	187272.Mlg_1092	9.032e-19	90.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,1RMM4@1236|Gammaproteobacteria,1WWG5@135613|Chromatiales	135613|Chromatiales	V	pfam abc	-	-	-	ko:K09695	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC_tran
HKD1_k127_7479688_14	1158756.AQXQ01000004_gene442	1.314e-37	147.0	COG3151@1|root,COG3151@2|Bacteria,1NAPI@1224|Proteobacteria,1SEY8@1236|Gammaproteobacteria,1WYT2@135613|Chromatiales	135613|Chromatiales	S	Protein of unknown function (DUF1249)	-	-	-	ko:K09920	-	-	-	-	ko00000	-	-	-	DUF1249
HKD1_k127_7479688_13	713587.THITH_10720	8.365e-66	228.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,1S3RW@1236|Gammaproteobacteria,1WY2N@135613|Chromatiales	135613|Chromatiales	K	Transcriptional regulator	-	-	-	ko:K13643	-	-	-	-	ko00000,ko03000	-	-	-	Rrf2
HKD1_k127_7479688_16	1123261.AXDW01000017_gene3211	2.159e-23	109.0	2DQ0C@1|root,33473@2|Bacteria,1NAM4@1224|Proteobacteria,1SCY6@1236|Gammaproteobacteria,1XB49@135614|Xanthomonadales	135614|Xanthomonadales	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_7479688_11	114615.BRADO6457	1.097e-77	262.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,2U5FG@28211|Alphaproteobacteria,3JY4S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_7479688_3	765910.MARPU_16470	1.796e-160	512.0	COG0337@1|root,COG0337@2|Bacteria,1MUBK@1224|Proteobacteria,1RN4I@1236|Gammaproteobacteria,1WWZW@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD1_k127_7479688_10	1111479.AXAR01000001_gene53	5.025e-78	275.0	COG3511@1|root,COG3511@2|Bacteria,1U22R@1239|Firmicutes,4HCD7@91061|Bacilli,279H4@186823|Alicyclobacillaceae	91061|Bacilli	M	Phosphoesterase family	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
HKD1_k127_7479688_19	266264.Rmet_5919	6.807e-07	54.0	COG1752@1|root,COG4775@1|root,COG1752@2|Bacteria,COG4775@2|Bacteria,1MUM9@1224|Proteobacteria,2VJRI@28216|Betaproteobacteria	28216|Betaproteobacteria	M	surface antigen variable number repeat protein	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Bac_surface_Ag,POTRA,Patatin
HKD1_k127_7479688_17	1457393.AZ09_00970	4.999e-19	92.0	2E560@1|root,32ZYT@2|Bacteria,1RD6P@1224|Proteobacteria,2UJ9J@28211|Alphaproteobacteria,2JXYX@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7479688_8	395961.Cyan7425_3895	3.054e-93	310.0	COG4122@1|root,COG4122@2|Bacteria,1G2Y6@1117|Cyanobacteria,3KGRF@43988|Cyanothece	1117|Cyanobacteria	H	PFAM O-methyltransferase family 3	-	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD1_k127_7479688_12	314278.NB231_13481	3.948e-75	261.0	COG1409@1|root,COG1409@2|Bacteria,1MWKX@1224|Proteobacteria,1RPA7@1236|Gammaproteobacteria,1WXST@135613|Chromatiales	135613|Chromatiales	S	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes	cpdA	-	3.1.4.53	ko:K03651	ko00230,ko02025,map00230,map02025	-	R00191	RC00296	ko00000,ko00001,ko01000	-	-	-	Metallophos
HKD1_k127_7479688_9	1026882.MAMP_01330	4.992e-78	265.0	COG0235@1|root,COG0235@2|Bacteria,1QAVF@1224|Proteobacteria,1RW3I@1236|Gammaproteobacteria,4628Z@72273|Thiotrichales	72273|Thiotrichales	G	PFAM Class II Aldolase and Adducin N-terminal domain	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD1_k127_7479688_15	582744.Msip34_2799	2.081e-27	111.0	COG1773@1|root,COG1773@2|Bacteria,1N731@1224|Proteobacteria,2VVP4@28216|Betaproteobacteria,2KN93@206350|Nitrosomonadales	206350|Nitrosomonadales	C	Rubredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD1_k127_7479688_7	396588.Tgr7_2419	2.526e-117	382.0	COG0351@1|root,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,1RNFP@1236|Gammaproteobacteria,1WXAI@135613|Chromatiales	135613|Chromatiales	H	Phosphomethylpyrimidine kinase	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_7479688_1	396588.Tgr7_2421	2.438e-208	654.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,1RM7N@1236|Gammaproteobacteria,1WWJU@135613|Chromatiales	135613|Chromatiales	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7479688_2	631362.Thi970DRAFT_01621	2.1e-207	649.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,1RNV6@1236|Gammaproteobacteria,1WVWR@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_7479688_0	472759.Nhal_0523	2.754e-247	767.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,1RMW8@1236|Gammaproteobacteria,1WVY5@135613|Chromatiales	135613|Chromatiales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_7479688_6	323848.Nmul_A2539	3.72e-127	412.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2VHHI@28216|Betaproteobacteria,3728C@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Methylenetetrahydrofolate reductase	metF	GO:0000166,GO:0003674,GO:0003824,GO:0004489,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006575,GO:0006725,GO:0006730,GO:0006732,GO:0006760,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009108,GO:0009396,GO:0009987,GO:0016043,GO:0016053,GO:0016491,GO:0016645,GO:0016646,GO:0018130,GO:0019438,GO:0019752,GO:0022607,GO:0034641,GO:0036094,GO:0042398,GO:0042558,GO:0042559,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046653,GO:0046654,GO:0048037,GO:0050660,GO:0050662,GO:0051186,GO:0051188,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0071704,GO:0071840,GO:0071949,GO:0097159,GO:1901265,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD1_k127_7487489_24	111781.Lepto7376_0316	5.7e-14	74.0	COG3039@1|root,COG3039@2|Bacteria,1G1EK@1117|Cyanobacteria,1HEKZ@1150|Oscillatoriales	1117|Cyanobacteria	L	SPTR Transposase, IS4 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_3
HKD1_k127_7487489_19	1125863.JAFN01000001_gene1323	1.662e-42	159.0	COG2402@1|root,COG2402@2|Bacteria,1NK19@1224|Proteobacteria,432DQ@68525|delta/epsilon subdivisions,2WY2Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_7487489_0	306281.AJLK01000161_gene235	0.0	1322.0	COG1452@1|root,COG1452@2|Bacteria,1G0TW@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Mannosyl oligosaccharide glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_63
HKD1_k127_7487489_2	1380391.JIAS01000020_gene1660	1.236e-165	530.0	COG1294@1|root,COG1294@2|Bacteria,1MURP@1224|Proteobacteria,2TU3I@28211|Alphaproteobacteria,2JQX2@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome bd terminal oxidase subunit II	-	-	1.10.3.14	ko:K00426	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_II
HKD1_k127_7487489_1	1054213.HMPREF9946_00712	1.505e-212	669.0	COG1271@1|root,COG1271@2|Bacteria,1MV60@1224|Proteobacteria,2TQMA@28211|Alphaproteobacteria,2JQM1@204441|Rhodospirillales	204441|Rhodospirillales	C	Cytochrome bd terminal oxidase subunit I	cydA	-	1.10.3.14	ko:K00425	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00153	R11325	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	Cyt_bd_oxida_I
HKD1_k127_7487489_20	215803.DB30_8533	1.571e-32	132.0	COG0596@1|root,COG0596@2|Bacteria,1RFKC@1224|Proteobacteria,439ND@68525|delta/epsilon subdivisions,2X4ZP@28221|Deltaproteobacteria,2YZWF@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_7487489_4	1288494.EBAPG3_26510	3.412e-147	480.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,372VN@32003|Nitrosomonadales	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7487489_5	1266925.JHVX01000001_gene2616	1.173e-123	407.0	COG2133@1|root,COG2133@2|Bacteria,1QZ0Q@1224|Proteobacteria,2WHH9@28216|Betaproteobacteria,3726U@32003|Nitrosomonadales	28216|Betaproteobacteria	G	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HKD1_k127_7487489_15	261292.Nit79A3_3290	4.763e-50	187.0	2AFU3@1|root,315WG@2|Bacteria,1PWFD@1224|Proteobacteria,2WBZV@28216|Betaproteobacteria,3742Z@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HKD1_k127_7487489_25	264198.Reut_A2380	3.407e-07	57.0	COG2932@1|root,COG2932@2|Bacteria,1Q94I@1224|Proteobacteria,2VW1H@28216|Betaproteobacteria,1K8HH@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Peptidase S24-like	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S24
HKD1_k127_7487489_18	1116472.MGMO_55c00260	1.11e-44	170.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,1SC6Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoE4	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_7487489_22	153948.NAL212_0834	1.215e-24	113.0	2ES5B@1|root,33JQ4@2|Bacteria,1NHPR@1224|Proteobacteria,2WCPB@28216|Betaproteobacteria,37485@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7487489_8	1116472.MGMO_55c00240	1.56e-102	349.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,1RNB8@1236|Gammaproteobacteria,1XFQY@135618|Methylococcales	135618|Methylococcales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_7487489_16	335543.Sfum_3731	8.197e-49	177.0	COG3189@1|root,COG3189@2|Bacteria,1MZ7H@1224|Proteobacteria,42U37@68525|delta/epsilon subdivisions,2WQ9M@28221|Deltaproteobacteria,2MRZA@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_7487489_6	404589.Anae109_0714	2.278e-115	388.0	COG1215@1|root,COG1215@2|Bacteria,1MX08@1224|Proteobacteria,42MS6@68525|delta/epsilon subdivisions,2WIYE@28221|Deltaproteobacteria,2YUMA@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_7487489_13	41431.PCC8801_0837	7.177e-52	188.0	COG4636@1|root,COG4636@2|Bacteria,1G5FE@1117|Cyanobacteria,3KJXX@43988|Cyanothece	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_7487489_26	357808.RoseRS_2740	7.494e-05	46.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_7487489_11	1131553.JIBI01000004_gene351	9.888e-70	248.0	COG1073@1|root,COG1073@2|Bacteria,1N595@1224|Proteobacteria	1224|Proteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD1_k127_7487489_14	478741.JAFS01000001_gene1215	3.081e-50	184.0	COG1881@1|root,COG1881@2|Bacteria,46T05@74201|Verrucomicrobia,37GQM@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD1_k127_7487489_10	472759.Nhal_1647	6.315e-73	250.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD1_k127_7487489_17	264198.Reut_B4601	4.654e-45	169.0	COG3245@1|root,COG3245@2|Bacteria,1RKPR@1224|Proteobacteria,2VTCA@28216|Betaproteobacteria	1224|Proteobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7487489_9	1122604.JONR01000031_gene1251	1.789e-82	281.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,1RRI3@1236|Gammaproteobacteria,1X68H@135614|Xanthomonadales	135614|Xanthomonadales	O	glutathione s-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_C
HKD1_k127_7487489_12	580332.Slit_2775	1.036e-69	245.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2VUQP@28216|Betaproteobacteria	28216|Betaproteobacteria	IQ	PFAM Short-chain dehydrogenase reductase SDR	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_7487489_7	240016.ABIZ01000001_gene574	9.688e-104	341.0	COG0406@1|root,COG0406@2|Bacteria,46T4J@74201|Verrucomicrobia,2IV5M@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD1_k127_7487489_21	313606.M23134_07653	1.051e-30	136.0	COG0682@1|root,COG0682@2|Bacteria	2|Bacteria	M	lipoprotein biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	LGT
HKD1_k127_7487489_23	383372.Rcas_2828	2.79e-19	102.0	COG3409@1|root,COG3409@2|Bacteria,2G8YJ@200795|Chloroflexi,377VF@32061|Chloroflexia	32061|Chloroflexia	M	Domain of unknown function (DUF4157)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4157
HKD1_k127_7487489_3	99598.Cal7507_3726	1.052e-149	480.0	COG0464@1|root,COG0464@2|Bacteria,1G1YA@1117|Cyanobacteria,1HMQN@1161|Nostocales	1117|Cyanobacteria	O	PFAM ATPase family associated with various cellular activities (AAA)	-	-	-	-	-	-	-	-	-	-	-	-	AAA
HKD1_k127_7494210_2	713586.KB900536_gene1824	2.098e-59	209.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,1RN8M@1236|Gammaproteobacteria,1WWRX@135613|Chromatiales	135613|Chromatiales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_7494210_4	331678.Cphamn1_1737	4.769e-38	153.0	COG0702@1|root,COG0702@2|Bacteria,1FE8P@1090|Chlorobi	1090|Chlorobi	C	PFAM NADH ubiquinone oxidoreductase complex I intermediate-associated protein 30	-	-	-	-	-	-	-	-	-	-	-	-	CIA30
HKD1_k127_7494210_3	349124.Hhal_2016	3.137e-45	168.0	COG0517@1|root,COG0517@2|Bacteria,1N2XI@1224|Proteobacteria,1SA5K@1236|Gammaproteobacteria,1WZKX@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	ko:K07182	-	-	-	-	ko00000	-	-	-	CBS
HKD1_k127_7494210_1	570952.ATVH01000018_gene3348	1.018e-120	394.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TSX9@28211|Alphaproteobacteria,2JPCE@204441|Rhodospirillales	204441|Rhodospirillales	BQ	COG0123 Deacetylases, including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD1_k127_7494210_0	713586.KB900536_gene841	4.263e-150	484.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1RPCQ@1236|Gammaproteobacteria,1X2AC@135613|Chromatiales	135613|Chromatiales	C	N-terminal domain of oxidoreductase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7589763_1	697282.Mettu_2209	4.43e-149	475.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,1XG1Z@135618|Methylococcales	135618|Methylococcales	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
HKD1_k127_7589763_2	375286.mma_3048	4.199e-132	428.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2VKAX@28216|Betaproteobacteria,4746R@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD1_k127_7589763_0	279714.FuraDRAFT_0693	1.555e-159	510.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,2VHAD@28216|Betaproteobacteria	28216|Betaproteobacteria	EG	metabolite transporter	cnrT	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_7589763_3	1123393.KB891326_gene35	4.677e-90	301.0	COG0491@1|root,COG0491@2|Bacteria,1NMU0@1224|Proteobacteria,2WBU4@28216|Betaproteobacteria,1KSJV@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7589763_8	306281.AJLK01000240_gene2864	9.992e-08	56.0	COG3415@1|root,COG3415@2|Bacteria,1GKNF@1117|Cyanobacteria,1JMRR@1189|Stigonemataceae	1117|Cyanobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
HKD1_k127_7589763_7	1521187.JPIM01000141_gene2767	4.143e-08	59.0	COG3415@1|root,COG3415@2|Bacteria,2G9BT@200795|Chloroflexi	200795|Chloroflexi	L	SPTR B0JN73 Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_32
HKD1_k127_7589763_5	247490.KSU1_D0773	2.971e-12	72.0	COG3335@1|root,COG3335@2|Bacteria,2IZSH@203682|Planctomycetes	203682|Planctomycetes	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_3
HKD1_k127_7589763_4	1304883.KI912532_gene1366	4.68e-53	203.0	COG3240@1|root,COG3240@2|Bacteria,1MWDI@1224|Proteobacteria,2VTBY@28216|Betaproteobacteria,2KXBE@206389|Rhodocyclales	206389|Rhodocyclales	I	GDSL-like Lipase/Acylhydrolase	-	-	-	ko:K12686	-	-	-	-	ko00000,ko02000,ko02044	1.B.12.8	-	-	Lipase_GDSL,VPEP
HKD1_k127_7589763_6	1132855.KB913035_gene108	4.919e-11	64.0	2E4FX@1|root,32ZB2@2|Bacteria,1NCDK@1224|Proteobacteria,2VXCG@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7591743_4	522306.CAP2UW1_2443	3.818e-19	89.0	2DYKW@1|root,34AA1@2|Bacteria,1P0V8@1224|Proteobacteria,2W4PE@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7591743_1	716544.wcw_0442	2.964e-123	403.0	COG1028@1|root,COG1028@2|Bacteria,2JG7F@204428|Chlamydiae	204428|Chlamydiae	IQ	KR domain	-	-	1.1.1.47	ko:K00034	ko00030,ko01120,ko01200,map00030,map01120,map01200	-	R01520,R01521	RC00066	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD1_k127_7591743_3	1122179.KB890423_gene2364	3.187e-68	250.0	COG2303@1|root,COG2303@2|Bacteria,4NEF2@976|Bacteroidetes,1IXR8@117747|Sphingobacteriia	976|Bacteroidetes	E	GMC oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD1_k127_7591743_2	251229.Chro_3613	7.172e-103	341.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_7591743_0	472759.Nhal_2468	9.761e-137	442.0	COG0303@1|root,COG0303@2|Bacteria,1MVD5@1224|Proteobacteria,1RMQU@1236|Gammaproteobacteria,1WVYA@135613|Chromatiales	135613|Chromatiales	H	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD1_k127_7596185_26	864702.OsccyDRAFT_5039	1.525e-23	99.0	COG4974@1|root,COG4974@2|Bacteria,1G224@1117|Cyanobacteria,1H8SW@1150|Oscillatoriales	1117|Cyanobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_7596185_12	765911.Thivi_3913	1.193e-100	329.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,1RP4R@1236|Gammaproteobacteria,1WW6I@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_7596185_15	349124.Hhal_1763	2.452e-80	274.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,1S2ET@1236|Gammaproteobacteria,1WWDD@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD1_k127_7596185_5	472759.Nhal_3697	1.175e-242	753.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,1RM98@1236|Gammaproteobacteria,1WWN5@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_7596185_17	713586.KB900536_gene3047	1.006e-75	257.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,1RN4C@1236|Gammaproteobacteria,1WWTG@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, E subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_7596185_6	396588.Tgr7_0991	3.943e-236	735.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,1RMUD@1236|Gammaproteobacteria,1WWH3@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_7596185_1	396588.Tgr7_0992	3.611e-298	934.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,1RMUH@1236|Gammaproteobacteria,1WWAH@135613|Chromatiales	135613|Chromatiales	C	TIGRFAM NADH-quinone oxidoreductase, chain G	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,Molydop_binding,NADH-G_4Fe-4S_3
HKD1_k127_7596185_10	1255043.TVNIR_3119	4.435e-164	521.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,1RQE9@1236|Gammaproteobacteria,1WXDH@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_7596185_14	323261.Noc_2557	4.443e-81	277.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,1RN32@1236|Gammaproteobacteria,1WWN9@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD1_k127_7596185_18	472759.Nhal_3691	6.466e-70	242.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,1S4ZA@1236|Gammaproteobacteria,1X25S@135613|Chromatiales	135613|Chromatiales	C	Belongs to the complex I subunit 6 family	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_7596185_23	472759.Nhal_3690	9.977e-43	158.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,1S6FN@1236|Gammaproteobacteria,1WYHG@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_7596185_2	1163617.SCD_n00950	1.877e-287	895.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2VJ2J@28216|Betaproteobacteria	28216|Betaproteobacteria	CP	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD1_k127_7596185_7	1049564.TevJSym_ap00500	1.448e-231	730.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,1RNI4@1236|Gammaproteobacteria,1J5MF@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD1_k127_7596185_8	396588.Tgr7_0999	1.303e-185	591.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,1RPJB@1236|Gammaproteobacteria,1WW6G@135613|Chromatiales	135613|Chromatiales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_7596185_32	1184609.KILIM_092_00100	2.543e-06	54.0	2BRZD@1|root,32KZR@2|Bacteria,2HDNI@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7596185_29	314278.NB231_09698	2.13e-07	53.0	COG3385@1|root,COG3385@2|Bacteria	2|Bacteria	L	transposase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimer_Tnp_Tn5
HKD1_k127_7596185_3	414684.RC1_1308	8.609e-257	804.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales	204441|Rhodospirillales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD1_k127_7596185_25	1238182.C882_2013	2.21e-32	131.0	COG5490@1|root,COG5490@2|Bacteria,1MZ74@1224|Proteobacteria,2UCS0@28211|Alphaproteobacteria,2JTK7@204441|Rhodospirillales	204441|Rhodospirillales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD1_k127_7596185_0	1123368.AUIS01000009_gene2455	0.0	1222.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,1RMA7@1236|Gammaproteobacteria,2NC0P@225057|Acidithiobacillales	225057|Acidithiobacillales	E	Domain of unknown function (DUF3458_C) ARM repeats	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD1_k127_7596185_13	653733.Selin_0426	1.496e-82	285.0	COG1560@1|root,COG1560@2|Bacteria	2|Bacteria	M	Kdo2-lipid A biosynthetic process	htrB	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD1_k127_7596185_28	626887.J057_17005	2.488e-14	74.0	2APBA@1|root,31EDH@2|Bacteria,1RIDJ@1224|Proteobacteria,1S6VZ@1236|Gammaproteobacteria,46BFH@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Putative prokaryotic signal transducing protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD1_k127_7596185_19	1026882.MAMP_01483	1.074e-61	220.0	COG2853@1|root,COG2853@2|Bacteria,1MVX0@1224|Proteobacteria,1RNPS@1236|Gammaproteobacteria,460P3@72273|Thiotrichales	72273|Thiotrichales	M	lipoprotein	-	-	-	ko:K04754	-	-	-	-	ko00000	-	-	-	MlaA
HKD1_k127_7596185_11	1415778.JQMM01000001_gene933	5.659e-118	388.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,1RMTW@1236|Gammaproteobacteria,1J9FJ@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7596185_16	1128421.JAGA01000002_gene1529	1.891e-78	268.0	COG0259@1|root,COG0259@2|Bacteria,2NQT9@2323|unclassified Bacteria	2|Bacteria	H	Pfam:PNPOx_C	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
HKD1_k127_7596185_4	1121033.AUCF01000031_gene96	1.403e-252	795.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2JQCH@204441|Rhodospirillales	204441|Rhodospirillales	I	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus	phbC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD1_k127_7596185_27	886293.Sinac_2435	3.367e-21	99.0	2EPIF@1|root,32K3X@2|Bacteria,2J1JT@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7596185_20	1182590.BN5_00507	1.79e-55	220.0	COG0784@1|root,COG2199@1|root,COG2200@1|root,COG0784@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1PJCA@1224|Proteobacteria,1RS4H@1236|Gammaproteobacteria,1YD18@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Putative diguanylate phosphodiesterase	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	EAL,GGDEF,PAS,PAS_8,PAS_9,Response_reg
HKD1_k127_7596185_31	156889.Mmc1_3226	1.856e-06	61.0	COG0642@1|root,COG0784@1|root,COG0834@1|root,COG2198@1|root,COG0784@2|Bacteria,COG0834@2|Bacteria,COG2198@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,Hpt,Response_reg,SBP_bac_3
HKD1_k127_7596185_33	1500894.JQNN01000001_gene445	0.0003527	54.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD1_k127_7596185_9	522306.CAP2UW1_3072	4.976e-178	561.0	COG0158@1|root,COG0158@2|Bacteria,1MW0E@1224|Proteobacteria,2VIJT@28216|Betaproteobacteria,1KPQH@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1	fbp	-	3.1.3.11,3.1.3.37	ko:K01086,ko:K03841	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko04152,ko04910,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map04152,map04910	M00003,M00165,M00167,M00344	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FBPase
HKD1_k127_7596185_22	472759.Nhal_1514	5.861e-45	168.0	COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,1SAYI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_7596185_24	1123368.AUIS01000025_gene1497	1.497e-37	143.0	2CECF@1|root,32RZM@2|Bacteria,1N130@1224|Proteobacteria,1S98I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	pilin assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7596185_21	243233.MCA0606	9.166e-50	184.0	COG3034@1|root,COG3034@2|Bacteria,1MXY6@1224|Proteobacteria,1S8WW@1236|Gammaproteobacteria,1XEZJ@135618|Methylococcales	135618|Methylococcales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_7596185_30	1118153.MOY_02929	1.378e-06	53.0	2EFUG@1|root,339KM@2|Bacteria,1NGQQ@1224|Proteobacteria,1SHZI@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(Lipo)protein	oprI	-	-	-	-	-	-	-	-	-	-	-	Alanine_zipper
HKD1_k127_7599116_11	1007105.PT7_2002	5.403e-05	47.0	COG2901@1|root,COG2901@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	fis	GO:0000018,GO:0000229,GO:0000785,GO:0000786,GO:0000787,GO:0000789,GO:0000976,GO:0000984,GO:0000985,GO:0001017,GO:0001046,GO:0001047,GO:0001067,GO:0001121,GO:0001130,GO:0001131,GO:0001140,GO:0001216,GO:0001217,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0003700,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005694,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008301,GO:0009058,GO:0009059,GO:0009314,GO:0009628,GO:0009889,GO:0009890,GO:0009891,GO:0009892,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010558,GO:0010604,GO:0010605,GO:0010628,GO:0010629,GO:0016032,GO:0016070,GO:0018130,GO:0019042,GO:0019045,GO:0019046,GO:0019219,GO:0019222,GO:0019438,GO:0031323,GO:0031324,GO:0031325,GO:0031326,GO:0031327,GO:0031328,GO:0031421,GO:0032359,GO:0032774,GO:0032991,GO:0032993,GO:0034641,GO:0034645,GO:0034654,GO:0042802,GO:0042803,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043565,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044374,GO:0044403,GO:0044419,GO:0044422,GO:0044424,GO:0044427,GO:0044444,GO:0044446,GO:0044464,GO:0044815,GO:0045892,GO:0045893,GO:0045911,GO:0045934,GO:0045935,GO:0046483,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0050896,GO:0051052,GO:0051054,GO:0051171,GO:0051172,GO:0051173,GO:0051252,GO:0051253,GO:0051254,GO:0051704,GO:0060255,GO:0065007,GO:0071704,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:0140110,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902679,GO:1902680,GO:1903506,GO:1903507,GO:1903508,GO:1990837,GO:2000112,GO:2000113,GO:2001141	-	ko:K03557,ko:K07712	ko02020,ko05111,map02020,map05111	M00497	-	-	ko00000,ko00001,ko00002,ko02022,ko03000,ko03036,ko03400	-	-	-	HTH_8
HKD1_k127_7599116_1	296591.Bpro_0011	4.096e-166	531.0	COG1373@1|root,COG1373@2|Bacteria,1MWBT@1224|Proteobacteria,2VK9X@28216|Betaproteobacteria,4ABVQ@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4143)	-	-	-	ko:K07133	-	-	-	-	ko00000	-	-	-	AAA_14,DUF4143
HKD1_k127_7599116_2	105559.Nwat_0552	1.485e-103	346.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,1RM8G@1236|Gammaproteobacteria,1WXND@135613|Chromatiales	135613|Chromatiales	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_7599116_0	396588.Tgr7_0981	2.915e-321	992.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,1RME8@1236|Gammaproteobacteria,1WX7K@135613|Chromatiales	135613|Chromatiales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_7599116_4	1042377.AFPJ01000023_gene683	3.341e-78	269.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,1RN5M@1236|Gammaproteobacteria,464RW@72275|Alteromonadaceae	1236|Gammaproteobacteria	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	GO:0000027,GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008650,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016043,GO:0016070,GO:0016072,GO:0016436,GO:0016740,GO:0016741,GO:0022607,GO:0022613,GO:0022618,GO:0031167,GO:0032259,GO:0034470,GO:0034622,GO:0034641,GO:0034660,GO:0042254,GO:0042255,GO:0042273,GO:0043170,GO:0043412,GO:0043414,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD1_k127_7599116_6	545276.KB898724_gene1852	1.887e-28	117.0	COG1534@1|root,COG1534@2|Bacteria,1N8K5@1224|Proteobacteria,1SDIM@1236|Gammaproteobacteria,1WYSK@135613|Chromatiales	135613|Chromatiales	J	CRS1_YhbY	-	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
HKD1_k127_7599116_8	859657.RPSI07_1564	9.648e-20	94.0	2AJXH@1|root,31AKJ@2|Bacteria,1RJPF@1224|Proteobacteria,2VTF5@28216|Betaproteobacteria,1KFR2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
HKD1_k127_7599116_3	105559.Nwat_1380	1.307e-91	308.0	COG2135@1|root,COG2135@2|Bacteria,1RER4@1224|Proteobacteria,1S3AX@1236|Gammaproteobacteria,1X2H3@135613|Chromatiales	135613|Chromatiales	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD1_k127_7599116_5	395493.BegalDRAFT_1254	4.142e-62	218.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,1S465@1236|Gammaproteobacteria,460R8@72273|Thiotrichales	72273|Thiotrichales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_7599116_7	1541960.KQ78_02283	4.328e-23	100.0	2E9JM@1|root,333SG@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7688325_15	404380.Gbem_1457	7.747e-17	81.0	COG1024@1|root,COG1024@2|Bacteria,1MWF6@1224|Proteobacteria,42QZY@68525|delta/epsilon subdivisions,2WMN5@28221|Deltaproteobacteria,43SVZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_7688325_4	240292.Ava_4094	3.239e-155	500.0	COG1473@1|root,COG1473@2|Bacteria,1G01G@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Peptidase family M20 M25 M40	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_7688325_13	96561.Dole_1589	1.622e-17	87.0	COG2267@1|root,COG2267@2|Bacteria	2|Bacteria	I	carboxylic ester hydrolase activity	catD	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD1_k127_7688325_10	472759.Nhal_0673	2.339e-54	195.0	COG0517@1|root,COG0517@2|Bacteria,1QYTE@1224|Proteobacteria,1T3TX@1236|Gammaproteobacteria,1WXSV@135613|Chromatiales	135613|Chromatiales	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_7688325_12	1411685.U062_01051	1.245e-31	127.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,1S8RT@1236|Gammaproteobacteria,1J6MP@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0000028,GO:0000217,GO:0000400,GO:0003674,GO:0003676,GO:0003677,GO:0003735,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006139,GO:0006259,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0016787,GO:0016788,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0046483,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD1_k127_7688325_8	519989.ECTPHS_00180	1.503e-64	230.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,1RNJ2@1236|Gammaproteobacteria,1WY0M@135613|Chromatiales	135613|Chromatiales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD1_k127_7688325_6	158822.LH89_17910	1.257e-103	342.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,1RMWC@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	Belongs to the RNA methyltransferase TrmD family	trmD	GO:0000287,GO:0001510,GO:0002939,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008173,GO:0008175,GO:0008757,GO:0009019,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0016772,GO:0016779,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0050518,GO:0052906,GO:0070567,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD1_k127_7688325_9	631362.Thi970DRAFT_02443	3.404e-56	199.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,1S5XX@1236|Gammaproteobacteria,1WYID@135613|Chromatiales	135613|Chromatiales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD1_k127_7688325_1	525903.Taci_1493	3.071e-315	988.0	COG0613@1|root,COG1196@1|root,COG0613@2|Bacteria,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	3.1.3.97	ko:K07053,ko:K18491	ko04550,map04550	-	R00188,R11188	RC00078	ko00000,ko00001,ko01000,ko03000	-	-	-	AAA_21,AAA_23,PHP,PHP_C
HKD1_k127_7688325_5	243159.AFE_3194	4.052e-130	427.0	COG2865@1|root,COG2865@2|Bacteria,1R4MD@1224|Proteobacteria,1RQTX@1236|Gammaproteobacteria,2NE00@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Putative DNA-binding domain	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
HKD1_k127_7688325_2	1366050.N234_10170	6.135e-307	955.0	COG1672@1|root,COG2319@1|root,COG1672@2|Bacteria,COG2319@2|Bacteria,1MWJA@1224|Proteobacteria,2VI8Q@28216|Betaproteobacteria,1K773@119060|Burkholderiaceae	28216|Betaproteobacteria	S	WD40 repeats	-	-	-	ko:K20332	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	NACHT,Pentapeptide,TIR_2,WD40
HKD1_k127_7688325_14	1449069.JMLO01000003_gene4137	6.628e-17	90.0	2DPYR@1|root,33401@2|Bacteria,2IJC2@201174|Actinobacteria,4G3X0@85025|Nocardiaceae	201174|Actinobacteria	S	Protein of unknown function (DUF4231)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4231
HKD1_k127_7688325_3	69042.WH5701_09219	1.315e-285	890.0	COG0457@1|root,COG0457@2|Bacteria,1GPNI@1117|Cyanobacteria,1H3JS@1129|Synechococcus	1117|Cyanobacteria	S	Domain of unknown function (DUF4071)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4071
HKD1_k127_7688325_7	1117958.PE143B_0102710	4.937e-75	274.0	COG1807@1|root,COG1807@2|Bacteria,1NTCC@1224|Proteobacteria	1224|Proteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_7688325_0	1128421.JAGA01000002_gene1368	0.0	1069.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,2NNW4@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses	nadE	GO:0003674,GO:0003824,GO:0003952,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008795,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016020,GO:0016874,GO:0016879,GO:0016880,GO:0016884,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0042802,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0071944,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.1.5,6.3.5.1	ko:K01916,ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00189,R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD1_k127_7688325_11	933262.AXAM01000018_gene1007	2.968e-46	178.0	COG3577@1|root,COG3577@2|Bacteria,1RIR3@1224|Proteobacteria,42UXY@68525|delta/epsilon subdivisions,2WR2W@28221|Deltaproteobacteria,2MM4V@213118|Desulfobacterales	28221|Deltaproteobacteria	L	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,DUF4124,gag-asp_proteas
HKD1_k127_7703998_9	472759.Nhal_3247	1.611e-45	175.0	COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1MXMD@1224|Proteobacteria,1RSI5@1236|Gammaproteobacteria,1WX0E@135613|Chromatiales	135613|Chromatiales	U	PEP-CTERM system TPR-repeat lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_4,TPR_8
HKD1_k127_7703998_1	1116472.MGMO_176c00080	7.146e-199	638.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria,1XG93@135618|Methylococcales	135618|Methylococcales	G	HpcH/HpaI aldolase/citrate lyase family	-	-	-	-	-	-	-	-	-	-	-	-	PK
HKD1_k127_7703998_4	314278.NB231_06041	4.542e-103	346.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,1RY7A@1236|Gammaproteobacteria,1WW45@135613|Chromatiales	135613|Chromatiales	H	Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway	bioC	-	2.1.1.197	ko:K02169	ko00780,ko01100,map00780,map01100	M00572	R09543	RC00003,RC00460	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11
HKD1_k127_7703998_8	519989.ECTPHS_09637	2.211e-51	194.0	COG2203@1|root,COG2203@2|Bacteria,1RG7F@1224|Proteobacteria,1SC3J@1236|Gammaproteobacteria,1X146@135613|Chromatiales	135613|Chromatiales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2
HKD1_k127_7703998_3	1249627.D779_1583	2.416e-121	401.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,1RPVP@1236|Gammaproteobacteria,1WX4Z@135613|Chromatiales	135613|Chromatiales	S	AI-2E family transporter	-	-	-	ko:K03548	-	-	-	-	ko00000,ko02000	2.A.86.1	-	-	AI-2E_transport
HKD1_k127_7703998_0	519989.ECTPHS_00095	1.418e-223	700.0	COG1875@1|root,COG1875@2|Bacteria,1MUX1@1224|Proteobacteria,1RMQN@1236|Gammaproteobacteria,1WWB1@135613|Chromatiales	135613|Chromatiales	T	SMART Nucleotide binding protein, PINc	-	-	-	ko:K07175	-	-	-	-	ko00000	-	-	-	PIN_4,PhoH
HKD1_k127_7703998_7	1318628.MARLIPOL_08514	4.131e-60	212.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,1RQ7F@1236|Gammaproteobacteria,46AS0@72275|Alteromonadaceae	1236|Gammaproteobacteria	O	Redoxin	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_7703998_6	1049564.TevJSym_ax00210	2.978e-67	233.0	COG2716@1|root,COG2716@2|Bacteria,1R7W7@1224|Proteobacteria,1RSDP@1236|Gammaproteobacteria,1JBWT@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	ACT domain	gcvR	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0097659,GO:1901360,GO:1901362,GO:1901576	-	ko:K03567	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	ACT,ACT_6
HKD1_k127_7703998_2	519989.ECTPHS_00110	8.288e-131	422.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,1RNH9@1236|Gammaproteobacteria,1WWMV@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_7703998_5	1123367.C666_07930	1.853e-87	302.0	COG3317@1|root,COG3317@2|Bacteria,1N670@1224|Proteobacteria,2VHS5@28216|Betaproteobacteria,2KUM7@206389|Rhodocyclales	206389|Rhodocyclales	M	(Lipo)protein	nlpB	-	-	ko:K07287	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	Lipoprotein_18
HKD1_k127_7788280_0	1183438.GKIL_3015	1.595e-191	604.0	COG0626@1|root,COG0626@2|Bacteria,1G43Q@1117|Cyanobacteria	1117|Cyanobacteria	E	cystathionine	metB	-	2.5.1.48,4.4.1.1	ko:K01739,ko:K01758	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00338	R00782,R00999,R01001,R01288,R02408,R02508,R03217,R03260,R04770,R04930,R04944,R04945,R04946,R09366	RC00020,RC00056,RC00069,RC00348,RC00382,RC00420,RC00710,RC01209,RC01210,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Cys_Met_Meta_PP
HKD1_k127_7788280_1	335543.Sfum_1291	2.255e-33	132.0	COG1959@1|root,COG1959@2|Bacteria,1PC6N@1224|Proteobacteria,43EVM@68525|delta/epsilon subdivisions,2X9SC@28221|Deltaproteobacteria,2MSFF@213462|Syntrophobacterales	28221|Deltaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_7801720_1	1094715.CM001373_gene2386	4.853e-215	677.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,1RPPF@1236|Gammaproteobacteria,1JCY4@118969|Legionellales	118969|Legionellales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_7801720_0	671143.DAMO_0410	6.698e-230	730.0	COG2060@1|root,COG2060@2|Bacteria,2NP13@2323|unclassified Bacteria	2|Bacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	GO:0003674,GO:0003824,GO:0005215,GO:0005488,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0008150,GO:0008324,GO:0008556,GO:0009987,GO:0015075,GO:0015077,GO:0015079,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0015672,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0030312,GO:0030955,GO:0031004,GO:0031224,GO:0031226,GO:0031420,GO:0032991,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043167,GO:0043169,GO:0043492,GO:0044425,GO:0044459,GO:0044464,GO:0046872,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0090533,GO:0090662,GO:0098533,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0099131,GO:0099132,GO:1902494,GO:1902495,GO:1904949,GO:1990351	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAPECO1_1312.APECO1_1369,iECUMN_1333.ECUMN_0780,iYL1228.KPN_00717	KdpA
HKD1_k127_7801720_2	335543.Sfum_2619	1.235e-28	121.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,42NGX@68525|delta/epsilon subdivisions,2WJC0@28221|Deltaproteobacteria,2MQBK@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	iAF987.Gmet_2434	E1-E2_ATPase,Hydrolase
HKD1_k127_7824201_1	395495.Lcho_3320	4.763e-160	527.0	COG3387@1|root,COG3387@2|Bacteria,1MXWR@1224|Proteobacteria,2W9PV@28216|Betaproteobacteria,1KN1S@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Glycosyl hydrolases family 15	-	-	-	ko:K07190	ko04020,ko04910,ko04922,map04020,map04910,map04922	-	-	-	ko00000,ko00001	-	-	-	Glyco_hydro_15
HKD1_k127_7824201_0	765914.ThisiDRAFT_0399	1.252e-204	642.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,1RMTB@1236|Gammaproteobacteria,1WWXH@135613|Chromatiales	135613|Chromatiales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_784636_1	381666.H16_B1765	5.188e-213	669.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2VHC1@28216|Betaproteobacteria,1K09M@119060|Burkholderiaceae	28216|Betaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520,ko:K21739	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_784636_0	261292.Nit79A3_0036	0.0	1283.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2VIGM@28216|Betaproteobacteria,372DE@32003|Nitrosomonadales	28216|Betaproteobacteria	G	aldehyde-lyase activity	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD1_k127_784636_8	1500259.JQLD01000008_gene1978	1.612e-06	50.0	COG3957@1|root,COG3957@2|Bacteria,1MVSE@1224|Proteobacteria,2TU2E@28211|Alphaproteobacteria,4B9N7@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Phosphoketolase	xfp	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD1_k127_784636_3	1040989.AWZU01000008_gene3646	1.503e-143	459.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2U25R@28211|Alphaproteobacteria,3JYBN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_784636_7	1040989.AWZU01000008_gene3647	4.441e-17	83.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTQ7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,DZR,Guanylate_cyc,SAM_1
HKD1_k127_784636_4	748247.AZKH_2770	2.36e-39	150.0	COG1310@1|root,COG1310@2|Bacteria,1RM6Z@1224|Proteobacteria,2VUNY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	JAB/MPN domain	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HKD1_k127_784636_6	638303.Thal_1379	4.499e-24	104.0	COG1977@1|root,COG1977@2|Bacteria,2G563@200783|Aquificae	200783|Aquificae	H	TIGRFAM MoaD family protein	-	-	-	ko:K03636	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_784636_2	1095769.CAHF01000006_gene1914	4.246e-190	600.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,1MW7H@1224|Proteobacteria,2VI1U@28216|Betaproteobacteria,472XC@75682|Oxalobacteraceae	28216|Betaproteobacteria	H	ThiF family	thiF	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD1_k127_784636_5	1095769.CAHF01000006_gene1913	4.937e-35	135.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2VJI3@28216|Betaproteobacteria,475IE@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Pyridoxal-phosphate dependent enzyme	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_7869711_1	765911.Thivi_3616	1.537e-125	408.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,1RMMT@1236|Gammaproteobacteria,1WWVU@135613|Chromatiales	135613|Chromatiales	M	Reutilizes the intact tripeptide L-alanyl-gamma-D- glutamyl-meso-diaminopimelate by linking it to UDP-N- acetylmuramate	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_7869711_2	876269.ARWA01000001_gene293	1.771e-119	390.0	COG1252@1|root,COG2259@1|root,COG1252@2|Bacteria,COG2259@2|Bacteria,1MX96@1224|Proteobacteria,2TQT2@28211|Alphaproteobacteria,3NBSI@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	ndh	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_7869711_3	743299.Acife_2622	4.478e-101	343.0	COG1252@1|root,COG2259@1|root,COG1252@2|Bacteria,COG2259@2|Bacteria,1MX96@1224|Proteobacteria,1RM9I@1236|Gammaproteobacteria,2NDMM@225057|Acidithiobacillales	225057|Acidithiobacillales	C	PFAM FAD-dependent pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885,ko:K15977	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxX,Pyr_redox_2
HKD1_k127_7869711_0	323261.Noc_1825	0.0	1411.0	COG1452@1|root,COG1452@2|Bacteria,1QW3G@1224|Proteobacteria,1T2RD@1236|Gammaproteobacteria,1WWPC@135613|Chromatiales	135613|Chromatiales	M	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7873772_3	519989.ECTPHS_03387	5.883e-162	522.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,1RNFI@1236|Gammaproteobacteria,1X2F6@135613|Chromatiales	135613|Chromatiales	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3663,Peptidase_M17
HKD1_k127_7873772_2	396588.Tgr7_2264	2.523e-177	567.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,1RPJF@1236|Gammaproteobacteria,1WWPA@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_7873772_5	85643.Tmz1t_1560	1.208e-20	96.0	COG3028@1|root,COG3028@2|Bacteria,1MZ4R@1224|Proteobacteria,2VSGZ@28216|Betaproteobacteria,2KWJZ@206389|Rhodocyclales	206389|Rhodocyclales	S	Belongs to the UPF0307 family	-	-	-	ko:K09889	-	-	-	-	ko00000,ko03009	-	-	-	DUF615
HKD1_k127_7873772_1	314278.NB231_05811	6.747e-231	722.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,1RMA5@1236|Gammaproteobacteria,1WWCQ@135613|Chromatiales	135613|Chromatiales	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_7873772_4	105559.Nwat_0461	3.06e-115	377.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,1RNVZ@1236|Gammaproteobacteria,1WW30@135613|Chromatiales	135613|Chromatiales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD1_k127_7873772_0	443143.GM18_1319	0.0	2348.0	COG3459@1|root,COG3459@2|Bacteria,1MVNX@1224|Proteobacteria,42PFN@68525|delta/epsilon subdivisions,2WJVD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	glycosyltransferase 36 associated	-	-	2.4.1.20	ko:K00702,ko:K13688	ko00500,ko01100,map00500,map01100	-	R00952	RC00049	ko00000,ko00001,ko01000,ko01003	-	GH94,GT36,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD1_k127_7888524_0	472759.Nhal_3076	4.461e-148	477.0	COG4974@1|root,COG4974@2|Bacteria,1PZTE@1224|Proteobacteria,1RPTV@1236|Gammaproteobacteria,1X0T3@135613|Chromatiales	135613|Chromatiales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_7888524_2	1042375.AFPL01000055_gene2241	2.196e-40	156.0	COG3945@1|root,COG3945@2|Bacteria,1RM01@1224|Proteobacteria,1S7CW@1236|Gammaproteobacteria,46CD2@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_7888524_1	1116472.MGMO_133c00180	3.657e-79	269.0	COG0067@1|root,COG0069@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,1MU7B@1224|Proteobacteria,1RN2W@1236|Gammaproteobacteria,1XEDS@135618|Methylococcales	135618|Methylococcales	E	Glutamate synthase	gltB	-	1.4.1.13,1.4.1.14	ko:K00265	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_7906136_3	713587.THITH_05045	3.93e-28	115.0	COG1423@1|root,COG1423@2|Bacteria,1R5ZS@1224|Proteobacteria,1S1X5@1236|Gammaproteobacteria,1X04B@135613|Chromatiales	135613|Chromatiales	L	PFAM ATP dependent DNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
HKD1_k127_7906136_2	224324.aq_1106	1.718e-40	154.0	COG1423@1|root,COG1423@2|Bacteria	2|Bacteria	L	RNA ligase	-	-	6.5.1.1	ko:K07468	-	-	R00381	RC00005	ko00000,ko01000	-	-	-	RNA_ligase
HKD1_k127_7906136_1	1313265.JNIE01000004_gene392	6.908e-67	233.0	COG1458@1|root,COG1458@2|Bacteria	2|Bacteria	S	PINc domain ribonuclease	-	-	-	ko:K09006	-	-	-	-	ko00000	-	-	-	DUF3368,PIN_5
HKD1_k127_7906136_0	472759.Nhal_3011	3.762e-142	485.0	COG0515@1|root,COG1262@1|root,COG3409@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,COG3409@2|Bacteria,1NQ5K@1224|Proteobacteria,1S2PN@1236|Gammaproteobacteria,1WYNY@135613|Chromatiales	135613|Chromatiales	KLT	PFAM Sulphatase-modifying factor	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PEGA,PG_binding_1,Pkinase
HKD1_k127_7930817_3	557598.LHK_02469	3.683e-46	174.0	COG4643@1|root,COG4643@2|Bacteria,1MW9E@1224|Proteobacteria,2VKFM@28216|Betaproteobacteria,2KQYF@206351|Neisseriales	206351|Neisseriales	S	Zinc-binding domain of primase-helicase	-	-	-	ko:K06919	-	-	-	-	ko00000	-	-	-	Prim_Zn_Ribbon,Toprim_3
HKD1_k127_7930817_5	261292.Nit79A3_2741	4.111e-23	101.0	2EPU8@1|root,33HEQ@2|Bacteria,1NJKT@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7930817_0	261292.Nit79A3_2739	4.268e-151	486.0	COG0582@1|root,COG0582@2|Bacteria,1NWGS@1224|Proteobacteria,2VKWM@28216|Betaproteobacteria,3744R@32003|Nitrosomonadales	28216|Betaproteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_7930817_4	396588.Tgr7_2217	6.648e-26	109.0	COG0425@1|root,COG0425@2|Bacteria,1MZA5@1224|Proteobacteria,1SCFA@1236|Gammaproteobacteria,1WYVX@135613|Chromatiales	135613|Chromatiales	O	Belongs to the sulfur carrier protein TusA family	-	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	TusA
HKD1_k127_7930817_2	314278.NB231_15073	2.671e-76	261.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	yfhC	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_7930817_1	526222.Desal_3401	9.672e-136	458.0	COG3829@1|root,COG3852@1|root,COG3829@2|Bacteria,COG3852@2|Bacteria,1QW3X@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg,SpoIIE
HKD1_k127_7941102_0	926569.ANT_14840	1.281e-240	760.0	COG2414@1|root,COG2414@2|Bacteria	2|Bacteria	C	aldehyde ferredoxin oxidoreductase activity	-	-	1.2.7.5,1.2.7.6	ko:K03738,ko:K11389	ko00010,ko00030,ko01100,ko01120,ko01200,ko01230,map00010,map00030,map01100,map01120,map01200,map01230	M00001,M00002,M00309	R07159,R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_7941102_3	1300345.LF41_1319	6.907e-30	126.0	COG0454@1|root,COG0456@2|Bacteria,1NCMN@1224|Proteobacteria,1SFS0@1236|Gammaproteobacteria,1X7VK@135614|Xanthomonadales	135614|Xanthomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD1_k127_7941102_1	395961.Cyan7425_3618	9.023e-101	336.0	COG0730@1|root,COG0730@2|Bacteria,1G5ZV@1117|Cyanobacteria	1117|Cyanobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_7941102_2	572477.Alvin_1499	8.498e-47	172.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RRGA@1236|Gammaproteobacteria,1WX0C@135613|Chromatiales	135613|Chromatiales	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.14	ko:K02594	ko00620,map00620	-	R00271	RC00004,RC00067,RC02754	ko00000,ko00001,ko01000	-	-	-	HMGL-like
HKD1_k127_7955187_0	870187.Thini_4167	9.384e-118	383.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,1RNQA@1236|Gammaproteobacteria,46068@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_7955187_3	472759.Nhal_2680	9.988e-20	95.0	COG2919@1|root,COG2919@2|Bacteria,1N7AA@1224|Proteobacteria,1SD8H@1236|Gammaproteobacteria,1WZ9J@135613|Chromatiales	135613|Chromatiales	D	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic	ftsB	-	-	ko:K05589	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD1_k127_7955187_1	765910.MARPU_02650	2.617e-83	284.0	COG1211@1|root,COG1211@2|Bacteria,1MY3B@1224|Proteobacteria,1S21S@1236|Gammaproteobacteria,1WXHT@135613|Chromatiales	135613|Chromatiales	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD1_k127_7955187_2	287.DR97_4312	5.576e-67	231.0	COG0245@1|root,COG0245@2|Bacteria,1MVHA@1224|Proteobacteria,1S3RQ@1236|Gammaproteobacteria,1YEPB@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0006732,GO:0006733,GO:0006743,GO:0006744,GO:0008150,GO:0008152,GO:0008270,GO:0008685,GO:0009058,GO:0009108,GO:0009987,GO:0016829,GO:0016849,GO:0030145,GO:0042180,GO:0042181,GO:0042802,GO:0043167,GO:0043169,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046872,GO:0046914,GO:0051186,GO:0051188,GO:0071704,GO:1901576,GO:1901661,GO:1901663	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	iPC815.YPO3360	YgbB
HKD1_k127_7976090_1	1283300.ATXB01000002_gene3021	1.043e-17	89.0	COG0810@1|root,COG0810@2|Bacteria,1QXPZ@1224|Proteobacteria,1T3FQ@1236|Gammaproteobacteria,1XH0Z@135618|Methylococcales	135618|Methylococcales	M	TolA C-terminal	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	TonB_2
HKD1_k127_7976090_2	76114.ebA2500	0.0009538	45.0	COG1609@1|root,COG1609@2|Bacteria,1R5GE@1224|Proteobacteria,2VVBU@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Rhodopirellula transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_ISAZ013
HKD1_k127_7976090_0	768671.ThimaDRAFT_3413	1.298e-228	718.0	COG0480@1|root,COG0480@2|Bacteria,1MVVY@1224|Proteobacteria,1RYCE@1236|Gammaproteobacteria,1WWXP@135613|Chromatiales	135613|Chromatiales	J	small GTP-binding protein	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD1_k127_8003466_6	768671.ThimaDRAFT_1279	4.534e-15	79.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,1S1PB@1236|Gammaproteobacteria,1WY6Q@135613|Chromatiales	135613|Chromatiales	S	COG3436 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
HKD1_k127_8003466_1	522306.CAP2UW1_3166	6.061e-50	184.0	COG4467@1|root,COG4467@2|Bacteria,1PPMF@1224|Proteobacteria,2VMNS@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Involved in initiation control of chromosome replication	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66
HKD1_k127_8003466_7	56107.Cylst_3903	1.112e-08	60.0	COG2886@1|root,COG2886@2|Bacteria,1G7YG@1117|Cyanobacteria,1HU6N@1161|Nostocales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0175	-	-	-	-	-	-	-	-	-	-	-	-	UPF0175
HKD1_k127_8003466_4	941449.dsx2_1822	1.048e-21	104.0	COG0697@1|root,COG0697@2|Bacteria,1QBAD@1224|Proteobacteria,42PAK@68525|delta/epsilon subdivisions,2WKBB@28221|Deltaproteobacteria,2M8G9@213115|Desulfovibrionales	28221|Deltaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_8003466_3	717772.THIAE_02005	1.222e-30	125.0	2E6MH@1|root,33183@2|Bacteria,1NDAB@1224|Proteobacteria,1SCGJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HKD1_k127_8003466_5	933262.AXAM01000018_gene986	2.937e-18	87.0	2EIHU@1|root,33C96@2|Bacteria,1NJTC@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_8003466_2	118166.JH976537_gene2421	6.673e-35	139.0	COG0639@1|root,COG0639@2|Bacteria,1GQ13@1117|Cyanobacteria,1HB32@1150|Oscillatoriales	1117|Cyanobacteria	T	Domain of unknown function DUF29	-	-	-	-	-	-	-	-	-	-	-	-	DUF29
HKD1_k127_8003466_0	314278.NB231_00450	5.007e-271	853.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,1RN48@1236|Gammaproteobacteria,1WXSZ@135613|Chromatiales	135613|Chromatiales	C	Oxidizes proline to glutamate for use as a carbon and nitrogen source	-	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HKD1_k127_8014188_2	572477.Alvin_3043	1.914e-42	157.0	2BDS5@1|root,327FW@2|Bacteria,1N15E@1224|Proteobacteria,1RSEH@1236|Gammaproteobacteria,1WXNG@135613|Chromatiales	135613|Chromatiales	S	PFAM NifQ	-	-	-	ko:K15790	-	-	-	-	ko00000	-	-	-	NifQ
HKD1_k127_8014188_0	580332.Slit_0832	4.943e-115	382.0	COG1397@1|root,COG1397@2|Bacteria,1NTUR@1224|Proteobacteria,2VM8T@28216|Betaproteobacteria,44WBK@713636|Nitrosomonadales	28216|Betaproteobacteria	O	ADP-ribosylglycohydrolase	draG	-	3.2.2.24	ko:K05521	-	-	-	-	ko00000,ko01000	-	-	-	ADP_ribosyl_GH
HKD1_k127_8014188_1	933262.AXAM01000026_gene3097	2.069e-48	175.0	COG1672@1|root,COG1672@2|Bacteria,1R4NN@1224|Proteobacteria,42NMV@68525|delta/epsilon subdivisions,2WM2Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,AAA_35
HKD1_k127_8014188_4	933262.AXAM01000026_gene3073	7.452e-07	50.0	COG1672@1|root,COG1672@2|Bacteria,1R4NN@1224|Proteobacteria,42NMV@68525|delta/epsilon subdivisions,2WM2Z@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Archaeal ATPase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22,AAA_35
HKD1_k127_8014188_3	118168.MC7420_1442	1.328e-10	64.0	COG4636@1|root,COG4636@2|Bacteria,1G2CH@1117|Cyanobacteria,1H8MY@1150|Oscillatoriales	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_8036201_8	314278.NB231_10068	6.469e-55	194.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,1RPWS@1236|Gammaproteobacteria,1WWTW@135613|Chromatiales	135613|Chromatiales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_8036201_6	1121935.AQXX01000124_gene128	5.317e-73	263.0	2C777@1|root,33SGB@2|Bacteria,1NTA9@1224|Proteobacteria,1SMRP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8036201_1	395493.BegalDRAFT_1494	4.787e-153	521.0	COG3264@1|root,COG3264@2|Bacteria,1MWSA@1224|Proteobacteria,1RMYY@1236|Gammaproteobacteria,463PS@72273|Thiotrichales	72273|Thiotrichales	M	ion channel	-	-	-	ko:K05802	-	-	-	-	ko00000,ko02000	1.A.23.1.1	-	-	MS_channel
HKD1_k127_8036201_7	488538.SAR116_0184	4.869e-56	213.0	COG0265@1|root,COG0265@2|Bacteria,1NVFS@1224|Proteobacteria,2UR8W@28211|Alphaproteobacteria,4BRVT@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	O	Trypsin	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_8036201_11	1121127.JAFA01000008_gene5735	2.883e-17	94.0	COG0457@1|root,COG0457@2|Bacteria,1NEE7@1224|Proteobacteria,2VUEI@28216|Betaproteobacteria,1K04B@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD1_k127_8036201_9	547144.HydHO_0333	1.891e-46	175.0	COG1842@1|root,COG1842@2|Bacteria	2|Bacteria	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD1_k127_8036201_5	105559.Nwat_0849	1.917e-95	322.0	28HK0@1|root,2Z7V0@2|Bacteria,1MXSJ@1224|Proteobacteria,1RRAP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4105)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4105
HKD1_k127_8036201_2	105559.Nwat_0840	1.185e-112	378.0	28MV6@1|root,2ZB2T@2|Bacteria,1R710@1224|Proteobacteria,1SMZR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8036201_10	1122603.ATVI01000012_gene1126	5.75e-37	143.0	COG2259@1|root,COG2259@2|Bacteria,1MZVP@1224|Proteobacteria,1S8UI@1236|Gammaproteobacteria,1X7J3@135614|Xanthomonadales	135614|Xanthomonadales	S	PFAM DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_8036201_4	640081.Dsui_0423	1.909e-95	324.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2VIIX@28216|Betaproteobacteria,2KW9W@206389|Rhodocyclales	206389|Rhodocyclales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_8036201_3	472759.Nhal_0597	4.225e-106	365.0	COG0642@1|root,COG2205@2|Bacteria,1MXF8@1224|Proteobacteria,1RMMI@1236|Gammaproteobacteria,1X2Q0@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS_8
HKD1_k127_8036201_0	399739.Pmen_0965	1.785e-159	514.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1RMCK@1236|Gammaproteobacteria,1YDVE@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Bacterial regulatory protein, Fis family	pilR	-	-	ko:K02481,ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_84687_3	1380394.JADL01000004_gene5983	3.048e-08	61.0	COG0671@1|root,COG0671@2|Bacteria,1NJBR@1224|Proteobacteria,2VC4B@28211|Alphaproteobacteria,2JXUQ@204441|Rhodospirillales	204441|Rhodospirillales	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD1_k127_84687_5	1122207.MUS1_03540	5.486e-06	55.0	COG3109@1|root,COG3109@2|Bacteria,1N68T@1224|Proteobacteria,1RP4S@1236|Gammaproteobacteria,1XJXH@135619|Oceanospirillales	135619|Oceanospirillales	T	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities	-	-	-	ko:K03607	-	-	-	-	ko00000	-	-	-	ProQ
HKD1_k127_84687_4	1173027.Mic7113_4054	2.532e-07	59.0	COG3781@1|root,COG3781@2|Bacteria,1G8MW@1117|Cyanobacteria,1HD9N@1150|Oscillatoriales	1117|Cyanobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_84687_1	497965.Cyan7822_2564	7.222e-81	280.0	COG1597@1|root,COG1597@2|Bacteria,1GMKF@1117|Cyanobacteria,3KKI7@43988|Cyanothece	1117|Cyanobacteria	I	lipid kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_84687_2	1340493.JNIF01000004_gene5	2.47e-67	235.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase
HKD1_k127_84687_0	269799.Gmet_3162	1.104e-165	531.0	COG0729@1|root,COG0729@2|Bacteria,1QXN0@1224|Proteobacteria,43C43@68525|delta/epsilon subdivisions,2X7EI@28221|Deltaproteobacteria,43TF9@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Surface antigen	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag
HKD1_k127_854861_1	247490.KSU1_D0671	5.084e-12	68.0	COG3848@1|root,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	-	-	2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1080,PEP-utilizers,PPDK_N
HKD1_k127_854861_0	909663.KI867150_gene2710	1.61e-51	196.0	COG3547@1|root,COG3547@2|Bacteria,1NGR7@1224|Proteobacteria,42NNQ@68525|delta/epsilon subdivisions,2WM2H@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_858810_0	1454004.AW11_03085	6.66e-182	583.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_858810_2	243233.MCA1839	5.873e-51	187.0	COG2930@1|root,COG2930@2|Bacteria,1RCH3@1224|Proteobacteria,1S2SV@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(twin-arginine translocation) pathway signal	VPA0371	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_858810_1	1454004.AW11_00199	3.224e-103	344.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2VV9Q@28216|Betaproteobacteria,1KR1Z@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_858810_4	1163617.SCD_n00744	1.792e-25	109.0	COG4190@1|root,COG4190@2|Bacteria,1N3VQ@1224|Proteobacteria,2VUVX@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_858810_3	1121374.KB891591_gene3526	7.592e-32	125.0	COG2261@1|root,COG2261@2|Bacteria,1N72Y@1224|Proteobacteria,1SCD4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	PFAM Transglycosylase-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_888323_0	330214.NIDE3851	1.465e-280	872.0	COG0365@1|root,COG0365@2|Bacteria,3J0BJ@40117|Nitrospirae	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_888323_1	330214.NIDE3854	9.825e-39	149.0	COG0508@1|root,COG0508@2|Bacteria	2|Bacteria	C	S-acyltransferase activity	aceF	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_888323_2	330214.NIDE3855	1.808e-21	98.0	COG0236@1|root,COG0236@2|Bacteria	2|Bacteria	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD1_k127_888323_3	1207063.P24_08249	3.988e-16	81.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TT3E@28211|Alphaproteobacteria,2JRMP@204441|Rhodospirillales	204441|Rhodospirillales	E	Pyridoxal-phosphate dependent enzyme	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD1_k127_888323_4	864069.MicloDRAFT_00007290	1.196e-13	72.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TT3E@28211|Alphaproteobacteria,1JZ5C@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Domain in cystathionine beta-synthase and other proteins.	-	-	4.2.1.22	ko:K01697	ko00260,ko00270,ko01100,ko01130,ko01230,map00260,map00270,map01100,map01130,map01230	M00035,M00338	R00891,R01290,R04942	RC00056,RC00069,RC00256,RC00489,RC01246	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD1_k127_904992_3	272123.Anacy_1363	6.53e-88	315.0	COG0553@1|root,COG0553@2|Bacteria,1G2YQ@1117|Cyanobacteria,1HME5@1161|Nostocales	1117|Cyanobacteria	L	Superfamily II DNA RNA helicase, SNF2 family	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N
HKD1_k127_904992_2	335543.Sfum_2811	3.147e-167	536.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2MRBD@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_904992_0	880072.Desac_0988	6.468e-301	938.0	COG0577@1|root,COG1136@1|root,COG0577@2|Bacteria,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,4308T@68525|delta/epsilon subdivisions,2X727@28221|Deltaproteobacteria,2MQXQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	V	Non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides	macB	-	-	ko:K02003,ko:K05685	ko02010,map02010	M00258,M00709	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.122.1,3.A.1.122.12	-	-	ABC_tran,FtsX,MacB_PCD
HKD1_k127_904992_1	335543.Sfum_2809	2.192e-180	577.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,42MRU@68525|delta/epsilon subdivisions,2WIQX@28221|Deltaproteobacteria,2MQS5@213462|Syntrophobacterales	28221|Deltaproteobacteria	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_922291_1	161156.JQKW01000013_gene141	3.268e-88	312.0	COG0668@1|root,COG0668@2|Bacteria	2|Bacteria	M	transmembrane transport	mscS	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_922291_0	382464.ABSI01000012_gene2033	1.226e-96	329.0	COG3258@1|root,COG3258@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_931452_9	1500306.JQLA01000045_gene2058	6.098e-55	202.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,4B9EZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	V	ABC transporter, ATP-binding protein	ybhF	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006855,GO:0008150,GO:0015562,GO:0015893,GO:0016020,GO:0022857,GO:0042221,GO:0042493,GO:0044464,GO:0050896,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_931452_6	1280948.HY36_06050	2.851e-63	229.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,44076@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	Biotin-lipoyl like	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_931452_13	631362.Thi970DRAFT_01793	9.947e-11	63.0	COG0641@1|root,COG0641@2|Bacteria	2|Bacteria	C	radical SAM	-	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,LysM,Radical_SAM,SPASM
HKD1_k127_931452_2	643473.KB235930_gene210	5.341e-117	386.0	COG4636@1|root,COG4636@2|Bacteria,1FZZW@1117|Cyanobacteria,1HKN7@1161|Nostocales	1117|Cyanobacteria	S	InterPro IPR008538	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_931452_1	1192034.CAP_4027	3.58e-159	522.0	COG0642@1|root,COG1352@1|root,COG5002@1|root,COG1352@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,CheR,CheR_N,GAF_2,HATPase_c,HisKA,PAS,PAS_10,PAS_4,PAS_9,Response_reg
HKD1_k127_931452_5	472759.Nhal_0114	8.467e-92	316.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RR5W@1236|Gammaproteobacteria,1WX8Z@135613|Chromatiales	135613|Chromatiales	T	Histidine kinase	-	-	2.7.13.3	ko:K02482,ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,MASE1,PAS_4,PAS_9,Response_reg
HKD1_k127_931452_8	765912.Thimo_2324	5.122e-55	201.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD1_k127_931452_4	768671.ThimaDRAFT_0614	2.276e-103	349.0	COG1376@1|root,COG1376@2|Bacteria,1MVYT@1224|Proteobacteria,1RMNC@1236|Gammaproteobacteria,1WXGI@135613|Chromatiales	135613|Chromatiales	M	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	SPOR,YkuD
HKD1_k127_931452_3	1499967.BAYZ01000017_gene6230	1.56e-114	385.0	COG2204@1|root,COG2204@2|Bacteria,2NQQY@2323|unclassified Bacteria	2|Bacteria	T	Sigma-54 interaction domain	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	FHA,GAF_3,HTH_8,Response_reg,Sigma54_activat
HKD1_k127_931452_10	1095767.CAHD01000083_gene1967	1.595e-54	205.0	2B69R@1|root,31Z77@2|Bacteria,2H1SG@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_931452_0	1095767.CAHD01000083_gene1966	9.542e-178	573.0	COG3497@1|root,COG3497@2|Bacteria	2|Bacteria	S	Phage tail sheath protein subtilisin-like domain	-	-	-	ko:K06907	-	-	-	-	ko00000	-	-	-	Phage_sheath_1,Phage_sheath_1C
HKD1_k127_931452_11	1120950.KB892791_gene1961	1.276e-53	194.0	28NKT@1|root,2ZBMH@2|Bacteria,2H2ZC@201174|Actinobacteria,4DTJY@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_931452_7	1068980.ARVW01000001_gene3667	1.468e-60	213.0	2C6Z3@1|root,32UIR@2|Bacteria,2H44B@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_962442_5	580332.Slit_0904	3.918e-133	434.0	COG2710@1|root,COG2710@2|Bacteria,1MWSX@1224|Proteobacteria,2VJNA@28216|Betaproteobacteria,44W97@713636|Nitrosomonadales	28216|Betaproteobacteria	C	Nitrogenase component 1 type Oxidoreductase	nifN	-	-	ko:K02592	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
HKD1_k127_962442_2	765912.Thimo_3647	3.233e-243	757.0	COG2710@1|root,COG2710@2|Bacteria,1MWAJ@1224|Proteobacteria,1RQ8X@1236|Gammaproteobacteria,1WW6F@135613|Chromatiales	135613|Chromatiales	C	Belongs to the NifD NifK NifE NifN family	-	-	-	ko:K02587	-	-	-	-	ko00000	-	-	-	Oxidored_nitro
HKD1_k127_962442_12	395493.BegalDRAFT_1626	4.927e-60	212.0	COG0716@1|root,COG0716@2|Bacteria,1MX7F@1224|Proteobacteria,1RMNT@1236|Gammaproteobacteria,4611D@72273|Thiotrichales	72273|Thiotrichales	C	Low-potential electron donor to a number of redox enzymes	-	-	-	ko:K03839,ko:K03840	-	-	-	-	ko00000	-	-	-	Flavodoxin_1
HKD1_k127_962442_11	395493.BegalDRAFT_1628	4.753e-66	233.0	COG1433@1|root,COG1433@2|Bacteria,1PW6J@1224|Proteobacteria,1S0X4@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Dinitrogenase iron-molybdenum cofactor	nifY	-	-	-	-	-	-	-	-	-	-	-	DIMCO_N,Nitro_FeMo-Co
HKD1_k127_962442_14	765913.ThidrDRAFT_2903	3.065e-23	100.0	COG5554@1|root,COG5554@2|Bacteria,1N7DQ@1224|Proteobacteria,1SD1T@1236|Gammaproteobacteria,1WYZ7@135613|Chromatiales	135613|Chromatiales	Q	PFAM NifT FixU	-	-	-	ko:K02593	-	-	-	-	ko00000	-	-	-	NifT
HKD1_k127_962442_0	1439940.BAY1663_02836	1.682e-278	863.0	COG2710@1|root,COG2710@2|Bacteria,1MWQ4@1224|Proteobacteria,1RMV3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	This molybdenum-iron protein is part of the nitrogenase complex that catalyzes the key enzymatic reactions in nitrogen fixation	nifK	-	1.18.6.1	ko:K02591	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF3364,Oxidored_nitro
HKD1_k127_962442_1	765914.ThisiDRAFT_0676	6.473e-264	820.0	COG2710@1|root,COG2710@2|Bacteria,1MVY2@1224|Proteobacteria,1RSFD@1236|Gammaproteobacteria,1WWPP@135613|Chromatiales	135613|Chromatiales	C	Nitrogenase molybdenum-iron protein alpha chain	-	-	1.18.6.1	ko:K02586	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Oxidored_nitro
HKD1_k127_962442_4	1212548.B381_01405	1.412e-157	501.0	COG1348@1|root,COG1348@2|Bacteria,1MVTE@1224|Proteobacteria,1RR82@1236|Gammaproteobacteria,1Z25Z@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	P	The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein	nifH	-	1.18.6.1	ko:K02588	ko00625,ko00910,ko01100,ko01120,map00625,map00910,map01100,map01120	M00175	R05185,R05496	RC00002,RC01395,RC02891	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4_NifH
HKD1_k127_962442_7	1249627.D779_1713	2.256e-105	348.0	28IJT@1|root,2Z8KN@2|Bacteria,1R6VB@1224|Proteobacteria,1RNYB@1236|Gammaproteobacteria,1WW5I@135613|Chromatiales	135613|Chromatiales	H	PFAM Dinitrogenase reductase ADP-ribosyltransferase	-	-	2.4.2.37	ko:K05951	-	-	-	-	ko00000,ko01000	-	-	-	DRAT
HKD1_k127_962442_3	1134912.AJTV01000047_gene3486	7.015e-199	640.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Arylsulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_962442_8	1454004.AW11_03085	5.199e-104	363.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_962442_9	1454004.AW11_03085	1.47e-99	328.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_962442_10	1454004.AW11_03085	1.761e-91	309.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_962442_6	1454004.AW11_03084	3.167e-116	383.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2W0N2@28216|Betaproteobacteria	28216|Betaproteobacteria	O	PPIC-type PPIASE domain	-	-	-	-	-	-	-	-	-	-	-	-	Rotamase_2
HKD1_k127_962442_13	1454004.AW11_03083	5.726e-40	158.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HKD1_k127_971330_17	1192124.LIG30_0820	5.483e-07	56.0	COG3391@1|root,COG3391@2|Bacteria,1R6BZ@1224|Proteobacteria,2W3VQ@28216|Betaproteobacteria,1K364@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Phosphoesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,Phosphoesterase
HKD1_k127_971330_0	1163408.UU9_11893	0.0	1567.0	COG0209@1|root,COG1372@1|root,COG0209@2|Bacteria,COG1372@2|Bacteria,1MUJ8@1224|Proteobacteria,1RQUR@1236|Gammaproteobacteria,1X2Z8@135614|Xanthomonadales	135614|Xanthomonadales	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD1_k127_971330_16	1123255.JHYS01000006_gene373	4.771e-11	70.0	2E3S7@1|root,32YPT@2|Bacteria,1N7D4@1224|Proteobacteria,2VUS8@28216|Betaproteobacteria,4AGCI@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_971330_14	765914.ThisiDRAFT_2096	7.756e-35	141.0	COG5616@1|root,COG5616@2|Bacteria,1QUK9@1224|Proteobacteria,1T3QH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_971330_13	768671.ThimaDRAFT_3843	5.93e-47	173.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,1S9G0@1236|Gammaproteobacteria,1WYDP@135613|Chromatiales	135613|Chromatiales	K	Ribosomal-protein-alanine acetyltransferase	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_971330_11	472759.Nhal_0660	5.056e-77	268.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,1S2U7@1236|Gammaproteobacteria,1WWN0@135613|Chromatiales	135613|Chromatiales	L	TIGRFAM Phage SPO1 DNA polymerase-related protein	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_971330_2	519989.ECTPHS_00530	1.016e-263	819.0	COG0119@1|root,COG0119@2|Bacteria,1MUNQ@1224|Proteobacteria,1RMWE@1236|Gammaproteobacteria,1WWU2@135613|Chromatiales	135613|Chromatiales	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_971330_9	1123400.KB904758_gene2336	3.897e-92	311.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,1RPBB@1236|Gammaproteobacteria,4603D@72273|Thiotrichales	72273|Thiotrichales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_971330_5	472759.Nhal_0737	9.99e-144	467.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,1RN6I@1236|Gammaproteobacteria,1WW8U@135613|Chromatiales	135613|Chromatiales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_971330_4	1120983.KB894575_gene732	2.533e-166	539.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,1JNCE@119043|Rhodobiaceae	28211|Alphaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	-	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
HKD1_k127_971330_3	1089551.KE386572_gene4323	6.123e-184	589.0	COG3131@1|root,COG3131@2|Bacteria,1MUNX@1224|Proteobacteria,2TRU1@28211|Alphaproteobacteria,4BR6D@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	P	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)	mdoD	-	-	ko:K03670	-	-	-	-	ko00000	-	-	-	MdoG
HKD1_k127_971330_1	243233.MCA0553	0.0	1042.0	COG3387@1|root,COG3387@2|Bacteria,1MW9J@1224|Proteobacteria,1T2G2@1236|Gammaproteobacteria,1XGVI@135618|Methylococcales	135618|Methylococcales	G	PFAM Glycoside hydrolase 15-related	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_971330_7	243233.MCA1924	2.392e-108	362.0	COG0395@1|root,COG0395@2|Bacteria,1N4I0@1224|Proteobacteria,1RYEC@1236|Gammaproteobacteria,1XFS1@135618|Methylococcales	135618|Methylococcales	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_971330_6	945713.IALB_1188	2.006e-124	405.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	lacF	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
HKD1_k127_971330_12	870187.Thini_2786	2.388e-48	177.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,460TU@72273|Thiotrichales	72273|Thiotrichales	Q	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family	tpm	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
HKD1_k127_971330_15	870187.Thini_2786	6.856e-20	91.0	COG0500@1|root,COG0500@2|Bacteria,1RAE4@1224|Proteobacteria,1S0RC@1236|Gammaproteobacteria,460TU@72273|Thiotrichales	72273|Thiotrichales	Q	Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family	tpm	-	2.1.1.67	ko:K00569	ko00983,map00983	-	R08236,R08239,R08246	RC00003,RC00980,RC02277	ko00000,ko00001,ko01000	-	-	-	TPMT
HKD1_k127_971330_10	211165.AJLN01000049_gene6077	2.57e-80	271.0	COG4636@1|root,COG4636@2|Bacteria,1GKRJ@1117|Cyanobacteria,1JMM4@1189|Stigonemataceae	1117|Cyanobacteria	S	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_971330_8	572547.Amico_0530	2.201e-101	338.0	COG2265@1|root,COG2265@2|Bacteria,3TAEF@508458|Synergistetes	508458|Synergistetes	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_U5-meth_tr
## 3522 queries scanned
## Total time (seconds): 71.59786748886108
## Rate: 49.19 q/s