## Fri Nov 15 20:31:37 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin8/HKD_1_bin.79.fa -m mmseqs --itype genome -o HKD_1_bin.79 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_1_bin.79 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1048226_32	1121382.JQKG01000009_gene712	5.895e-07	58.0	COG1404@1|root,COG1404@2|Bacteria,1WJ91@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	-	-	-	ko:K14645	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	Peptidase_S8
HKD1_k127_1048226_29	1157490.EL26_02480	1.989e-11	76.0	COG5549@1|root,COG5549@2|Bacteria	2|Bacteria	O	protein import	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10,Reprolysin_3
HKD1_k127_1048226_8	861299.J421_4076	3.1e-126	418.0	COG2159@1|root,COG2159@2|Bacteria	2|Bacteria	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_1048226_2	886293.Sinac_5685	1.933e-223	711.0	COG0308@1|root,COG0308@2|Bacteria,2J268@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Leukotriene A4 hydrolase, C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Leuk-A4-hydro_C,Peptidase_M1
HKD1_k127_1048226_15	234267.Acid_7795	3.102e-74	254.0	COG1595@1|root,COG1595@2|Bacteria,3Y4KQ@57723|Acidobacteria	57723|Acidobacteria	K	region 4 type 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_1048226_23	234267.Acid_7794	7.49e-25	110.0	2E5Q2@1|root,330EP@2|Bacteria,3Y5RC@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1048226_19	42345.XP_008778491.1	1.285e-51	205.0	COG3934@1|root,2QS4Q@2759|Eukaryota,37PFM@33090|Viridiplantae,3GCR2@35493|Streptophyta,3KM9V@4447|Liliopsida	35493|Streptophyta	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004567,GO:0005975,GO:0005976,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0010412,GO:0015923,GO:0016052,GO:0016787,GO:0016798,GO:0016985,GO:0016998,GO:0043170,GO:0044036,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0046355,GO:0071554,GO:0071704,GO:1901575	3.2.1.78	ko:K19355	ko00051,map00051	-	R01332	RC00467	ko00000,ko00001,ko01000	-	-	-	Cellulase
HKD1_k127_1048226_4	1242864.D187_008887	3.537e-160	521.0	COG0737@1|root,COG0737@2|Bacteria,1MX03@1224|Proteobacteria,42Q71@68525|delta/epsilon subdivisions,2WK8Q@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,EF-hand_5,Metallophos
HKD1_k127_1048226_13	1283299.AUKG01000002_gene4588	2.863e-75	266.0	COG3320@1|root,COG3320@2|Bacteria,2GKZY@201174|Actinobacteria,4CPPS@84995|Rubrobacteria	84995|Rubrobacteria	Q	Male sterility protein	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_4
HKD1_k127_1048226_17	1128421.JAGA01000002_gene1529	9.281e-72	248.0	COG0259@1|root,COG0259@2|Bacteria,2NQT9@2323|unclassified Bacteria	2|Bacteria	H	Pfam:PNPOx_C	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
HKD1_k127_1048226_7	1382359.JIAL01000001_gene3046	1.916e-128	426.0	COG1160@1|root,COG1160@2|Bacteria,3Y3AC@57723|Acidobacteria,2JIAS@204432|Acidobacteriia	204432|Acidobacteriia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD1_k127_1048226_5	269799.Gmet_0852	2.042e-136	444.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,42M5Y@68525|delta/epsilon subdivisions,2WIMT@28221|Deltaproteobacteria,43TNC@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_1048226_25	243275.TDE_0682	3.178e-20	93.0	COG1862@1|root,COG1862@2|Bacteria,2J8D6@203691|Spirochaetes	203691|Spirochaetes	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD1_k127_1048226_9	204669.Acid345_0146	4.448e-112	382.0	COG0342@1|root,COG0342@2|Bacteria,3Y37S@57723|Acidobacteria,2JHJC@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_1048226_16	639030.JHVA01000001_gene2636	7.771e-73	258.0	COG0341@1|root,COG0341@2|Bacteria,3Y2ZT@57723|Acidobacteria,2JHZF@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_1048226_27	401053.AciPR4_4001	3.397e-17	91.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_1048226_12	234267.Acid_1281	1.304e-77	267.0	COG0811@1|root,COG0811@2|Bacteria,3Y2M4@57723|Acidobacteria	57723|Acidobacteria	U	MotA TolQ ExbB proton channel	-	-	-	ko:K03561,ko:K03562	ko01120,map01120	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	MotA_ExbB
HKD1_k127_1048226_24	204669.Acid345_0150	2.582e-23	105.0	COG0848@1|root,COG0848@2|Bacteria,3Y4TE@57723|Acidobacteria,2JJKY@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HKD1_k127_1048226_28	1198114.AciX9_3619	1.593e-12	74.0	COG0848@1|root,COG0848@2|Bacteria,3Y5AP@57723|Acidobacteria,2JJQV@204432|Acidobacteriia	204432|Acidobacteriia	U	PFAM Biopolymer transport protein ExbD TolR	-	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HKD1_k127_1048226_31	234267.Acid_1284	5.702e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,3Y3N5@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HKD1_k127_1048226_1	234267.Acid_1285	4.898e-249	788.0	COG0317@1|root,COG0317@2|Bacteria,3Y38Q@57723|Acidobacteria	57723|Acidobacteria	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_1048226_11	497964.CfE428DRAFT_2268	5.888e-79	284.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_1048226_10	1463887.KL589975_gene5365	5.873e-95	328.0	COG0612@1|root,COG0612@2|Bacteria,2GJZ3@201174|Actinobacteria	201174|Actinobacteria	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_1048226_20	269799.Gmet_2522	2.369e-41	156.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,42RNC@68525|delta/epsilon subdivisions,2WP7G@28221|Deltaproteobacteria,43V0M@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	GO:0003674,GO:0005215,GO:0005575,GO:0006810,GO:0006811,GO:0006884,GO:0008150,GO:0008361,GO:0008381,GO:0009987,GO:0009992,GO:0015267,GO:0016020,GO:0016021,GO:0016043,GO:0019725,GO:0022803,GO:0022836,GO:0022857,GO:0030104,GO:0031224,GO:0032535,GO:0042592,GO:0044425,GO:0048878,GO:0051179,GO:0051234,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071840,GO:0090066	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_1048226_22	1337936.IJ00_22865	3.793e-25	111.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	CBS,GAF,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_1048226_18	243231.GSU0388	1.565e-52	192.0	COG1392@1|root,COG1392@2|Bacteria,1R4SP@1224|Proteobacteria,42SPV@68525|delta/epsilon subdivisions,2WPTH@28221|Deltaproteobacteria,43SW8@69541|Desulfuromonadales	28221|Deltaproteobacteria	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD1_k127_1048226_6	1173026.Glo7428_1305	5.628e-133	432.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1G1R7@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kpsF	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD1_k127_1048226_0	234267.Acid_2017	1.278e-264	838.0	COG1506@1|root,COG1506@2|Bacteria,3Y2HK@57723|Acidobacteria	57723|Acidobacteria	E	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD1_k127_1048226_14	1340493.JNIF01000004_gene275	3.674e-75	278.0	COG0515@1|root,COG0515@2|Bacteria	1340493.JNIF01000004_gene275|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1048226_26	237368.SCABRO_01702	5.618e-18	90.0	COG0792@1|root,COG0792@2|Bacteria,2J0GX@203682|Planctomycetes	203682|Planctomycetes	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD1_k127_1048226_33	262724.TT_C1030	9.944e-06	49.0	2CAKS@1|root,30Q0J@2|Bacteria,1WKSR@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	J	30S ribosomal protein Thx	-	-	-	ko:K19033	-	-	-	-	br01610,ko00000,ko03011	-	-	-	Thx
HKD1_k127_1048226_3	1267534.KB906754_gene2572	2.244e-162	523.0	COG1473@1|root,COG1473@2|Bacteria,3Y40E@57723|Acidobacteria,2JIBT@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_1048226_21	865861.AZSU01000003_gene1806	4.967e-37	147.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,36ITW@31979|Clostridiaceae	186801|Clostridia	L	nudix family	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_1058044_6	671143.DAMO_0569	1.136e-30	128.0	COG0779@1|root,COG0779@2|Bacteria,2NPVA@2323|unclassified Bacteria	2|Bacteria	S	Required for maturation of 30S ribosomal subunits	rimP	GO:0000028,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0071944,GO:1901564,GO:1901566,GO:1901576	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD1_k127_1058044_1	234267.Acid_5180	1.658e-118	401.0	COG0195@1|root,COG0195@2|Bacteria,3Y379@57723|Acidobacteria	57723|Acidobacteria	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD1_k127_1058044_0	1382359.JIAL01000001_gene1877	9.749e-218	706.0	COG0532@1|root,COG0532@2|Bacteria,3Y3UG@57723|Acidobacteria,2JHXH@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,GTP_EFTU_D2,IF-2,IF2_N
HKD1_k127_1058044_7	646529.Desaci_3543	3.788e-21	97.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,262H0@186807|Peptococcaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD1_k127_1058044_4	204669.Acid345_4214	1.407e-80	279.0	COG0618@1|root,COG0618@2|Bacteria,3Y2GZ@57723|Acidobacteria,2JI0W@204432|Acidobacteriia	204432|Acidobacteriia	S	DHH family	-	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_1058044_5	485913.Krac_2076	1.511e-54	197.0	COG2109@1|root,COG2109@2|Bacteria,2G6Q6@200795|Chloroflexi	200795|Chloroflexi	H	PFAM ATP corrinoid adenosyltransferase BtuR CobO CobP	-	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
HKD1_k127_1058044_2	1340493.JNIF01000003_gene1295	3.313e-99	332.0	COG0777@1|root,COG0777@2|Bacteria,3Y2U9@57723|Acidobacteria	57723|Acidobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_1058044_3	1267535.KB906767_gene3782	1.149e-81	287.0	COG0285@1|root,COG0285@2|Bacteria,3Y3ZA@57723|Acidobacteria,2JI7I@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM Mur ligase	-	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_105957_13	450851.PHZ_c1673	9.936e-93	314.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_105957_24	267608.RSc3167	1.013e-06	56.0	COG0457@1|root,COG0457@2|Bacteria,1MUMZ@1224|Proteobacteria,2VZN8@28216|Betaproteobacteria,1KGFG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_17
HKD1_k127_105957_15	1382304.JNIL01000001_gene14	3.759e-67	244.0	COG0477@1|root,COG2814@2|Bacteria,1TPPY@1239|Firmicutes,4HNJ9@91061|Bacilli	91061|Bacilli	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_105957_11	614083.AWQR01000039_gene1483	3.027e-104	347.0	COG5514@1|root,COG5514@2|Bacteria,1MX90@1224|Proteobacteria,2VIMN@28216|Betaproteobacteria,4AA3M@80864|Comamonadaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF1794)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1794
HKD1_k127_105957_3	1340493.JNIF01000004_gene652	2.054e-263	826.0	COG2274@1|root,COG2274@2|Bacteria	2|Bacteria	V	protein secretion by the type I secretion system	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HKD1_k127_105957_22	485913.Krac_8871	1.593e-31	128.0	COG1733@1|root,COG1733@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_105957_9	1244869.H261_02871	5.01e-119	394.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,2JRIF@204441|Rhodospirillales	204441|Rhodospirillales	C	COG1902 NADH flavin oxidoreductases, Old Yellow Enzyme family	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD1_k127_105957_6	1379698.RBG1_1C00001G1167	2.81e-134	436.0	COG0265@1|root,COG0265@2|Bacteria,2NNVS@2323|unclassified Bacteria	2|Bacteria	O	smart pdz dhr glgf	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_105957_7	1382359.JIAL01000001_gene350	3.483e-125	411.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	rip3	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0005887,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0030312,GO:0031224,GO:0031226,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	-	ko:K06212,ko:K06402	-	-	-	-	ko00000,ko01000,ko01002,ko02000	1.A.16.1.1,1.A.16.1.3	-	-	CBS,Form_Nir_trans,Peptidase_M50,Peptidase_M50B
HKD1_k127_105957_5	316067.Geob_3759	7.098e-141	454.0	COG0205@1|root,COG0205@2|Bacteria,1MVN3@1224|Proteobacteria,42Q5V@68525|delta/epsilon subdivisions,2WJA1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_105957_19	1057002.KB905370_gene4104	1.088e-53	203.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,2TVGG@28211|Alphaproteobacteria,4BCEZ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_105957_0	639030.JHVA01000001_gene3668	0.0	1047.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,3Y950@57723|Acidobacteria	57723|Acidobacteria	G	PEP-utilising enzyme, mobile domain	-	-	-	-	-	-	-	-	-	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_105957_10	118173.KB235910_gene4617	2.125e-109	362.0	COG1136@1|root,COG1136@2|Bacteria,1G4IP@1117|Cyanobacteria,1HA7Y@1150|Oscillatoriales	1117|Cyanobacteria	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_105957_1	1173023.KE650771_gene5325	3.981e-291	913.0	COG0577@1|root,COG0577@2|Bacteria,1G0Z7@1117|Cyanobacteria	1117|Cyanobacteria	V	ABC-type transport system involved in lipoprotein release permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_105957_12	118163.Ple7327_2496	8.085e-95	324.0	COG0845@1|root,COG0845@2|Bacteria,1G29R@1117|Cyanobacteria	1117|Cyanobacteria	M	Rnd family efflux transporter mfp subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD1_k127_105957_18	404589.Anae109_2807	3.041e-54	195.0	COG0346@1|root,COG0346@2|Bacteria,1MZD3@1224|Proteobacteria,434M2@68525|delta/epsilon subdivisions,2X8XQ@28221|Deltaproteobacteria,2Z0XI@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	ko:K08234	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_105957_23	1034807.FBFL15_1786	2.349e-08	66.0	292UM@1|root,2ZQC9@2|Bacteria,4NTGF@976|Bacteroidetes,1I2BB@117743|Flavobacteriia,2NYA7@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_105957_8	42256.RradSPS_0572	3.657e-120	415.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4CQM5@84995|Rubrobacteria	84995|Rubrobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD1_k127_105957_14	1278073.MYSTI_06128	5.306e-83	304.0	COG4531@1|root,COG4531@2|Bacteria,1REHQ@1224|Proteobacteria,42TZ1@68525|delta/epsilon subdivisions,2WQ6N@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_105957_21	1297742.A176_05067	1.669e-40	156.0	COG2010@1|root,COG2010@2|Bacteria,1RHGQ@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_105957_20	246197.MXAN_5555	7.86e-45	168.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	actD	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD1_k127_105957_4	1121920.AUAU01000008_gene1613	1.051e-211	666.0	COG5557@1|root,COG5557@2|Bacteria,3Y3NS@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_105957_2	1121920.AUAU01000008_gene1614	1.307e-269	861.0	COG0437@1|root,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	2|Bacteria	C	4Fe-4S dicluster domain	actB	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molybdop_Fe4S4,Molydop_binding
HKD1_k127_105957_17	483219.LILAB_35270	4.874e-55	198.0	COG2010@1|root,COG2010@2|Bacteria,1P88Q@1224|Proteobacteria,43BRV@68525|delta/epsilon subdivisions,2X73R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII,Cytochrome_C7
HKD1_k127_105957_16	1121920.AUAU01000008_gene1616	1.869e-61	222.0	COG2181@1|root,COG2181@2|Bacteria	2|Bacteria	C	nitrate reductase activity	narI	GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006950,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009628,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0020037,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0032991,GO:0036293,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0046906,GO:0048037,GO:0050896,GO:0055114,GO:0070469,GO:0070470,GO:0070482,GO:0071944,GO:0097159,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204	1.7.5.1	ko:K00370,ko:K00374,ko:K02575	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00615,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.1.8,5.A.3.1	-	iEC042_1314.EC042_1594,iECABU_c1320.ECABU_c17020,iECUMN_1333.ECUMN_1718,iNJ661.Rv1164,iSF_1195.SF1230,ic_1306.c1897	Nitrate_red_gam
HKD1_k127_1079821_1	1267535.KB906767_gene2092	4.326e-101	342.0	COG0842@1|root,COG0842@2|Bacteria,3Y73W@57723|Acidobacteria	57723|Acidobacteria	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_1079821_7	644282.Deba_2882	1.191e-47	177.0	COG1309@1|root,COG1309@2|Bacteria,1MV2V@1224|Proteobacteria,42NW6@68525|delta/epsilon subdivisions,2WPIG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	PFAM regulatory protein TetR	-	-	-	ko:K13770	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
HKD1_k127_1079821_0	1382359.JIAL01000001_gene2768	1.418e-139	465.0	COG1022@1|root,COG1022@2|Bacteria,3Y2KU@57723|Acidobacteria,2JHTA@204432|Acidobacteriia	204432|Acidobacteriia	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD1_k127_1079821_8	595536.ADVE02000001_gene769	4.484e-31	131.0	COG0543@1|root,COG0543@2|Bacteria,1R6QZ@1224|Proteobacteria,2V487@28211|Alphaproteobacteria,36ZQF@31993|Methylocystaceae	28211|Alphaproteobacteria	CH	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	-	-	-	-	-	-	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HKD1_k127_1079821_3	204669.Acid345_2272	2.129e-82	285.0	COG2010@1|root,COG2010@2|Bacteria,3Y5ZT@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_1079821_2	1499967.BAYZ01000178_gene4651	1.519e-87	302.0	COG0763@1|root,COG0763@2|Bacteria,2NP10@2323|unclassified Bacteria	2|Bacteria	I	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	GO:0003674,GO:0005488,GO:0005543,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006629,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008289,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0019637,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044424,GO:0044444,GO:0044464,GO:0046467,GO:0046493,GO:0071704,GO:0090407,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD1_k127_1079821_4	1267535.KB906767_gene1489	3.637e-78	291.0	COG1452@1|root,COG1452@2|Bacteria,3Y37B@57723|Acidobacteria,2JHPP@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Organic solvent tolerance protein	-	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA_C
HKD1_k127_1079821_5	234267.Acid_3219	5.171e-70	271.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1079821_11	163908.KB235896_gene1305	7.869e-06	60.0	COG2931@1|root,COG3210@1|root,COG3240@1|root,COG4222@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,COG3240@2|Bacteria,COG4222@2|Bacteria,1GA8X@1117|Cyanobacteria	1117|Cyanobacteria	Q	CHRD domain	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
HKD1_k127_1079821_10	671143.DAMO_2857	9.666e-07	63.0	COG0823@1|root,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD1_k127_1079821_12	1340493.JNIF01000003_gene1438	1.997e-05	59.0	COG1075@1|root,COG3170@1|root,COG3386@1|root,COG1075@2|Bacteria,COG3170@2|Bacteria,COG3386@2|Bacteria,3Y3S3@57723|Acidobacteria	57723|Acidobacteria	G	PFAM NHL repeat containing protein	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_1,Big_3_5,NHL
HKD1_k127_1079821_6	635013.TherJR_2843	8.079e-60	221.0	COG0297@1|root,COG0438@1|root,COG0297@2|Bacteria,COG0438@2|Bacteria,1UASH@1239|Firmicutes,248VW@186801|Clostridia,262C0@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl	-	-	2.4.1.349	ko:K12994	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_1079821_9	5888.CAK86317	9.871e-27	120.0	COG0463@1|root,KOG2978@2759|Eukaryota,3ZARU@5878|Ciliophora	5878|Ciliophora	M	Glycosyltransferase like family 2	-	-	2.4.1.83	ko:K00721	ko00510,ko01100,map00510,map01100	-	R01009	RC00005	ko00000,ko00001,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_1080021_11	1408433.JHXV01000006_gene2654	3.498e-10	75.0	COG4935@1|root,COG4935@2|Bacteria,4NRQR@976|Bacteroidetes	976|Bacteroidetes	O	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1080021_8	497964.CfE428DRAFT_4476	6.299e-43	183.0	COG1520@1|root,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	I-set,Ig_3,PQQ_2
HKD1_k127_1080021_10	643473.KB235930_gene1727	3.624e-13	85.0	COG2133@1|root,COG2373@1|root,COG2931@1|root,COG2133@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,1G2CB@1117|Cyanobacteria,1HRM4@1161|Nostocales	1117|Cyanobacteria	G	PA14	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,GSDH,Lectin_C,PA14
HKD1_k127_1080021_15	218284.CCDN010000002_gene2334	1.591e-05	47.0	COG4632@1|root,COG4632@2|Bacteria,1UV25@1239|Firmicutes,4I5JA@91061|Bacilli,1ZEFI@1386|Bacillus	91061|Bacilli	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA,SPOR
HKD1_k127_1080021_2	518766.Rmar_2028	2.087e-102	369.0	COG0457@1|root,COG3829@1|root,COG0457@2|Bacteria,COG3829@2|Bacteria,4PM5Y@976|Bacteroidetes,1FIME@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_1080021_12	1340493.JNIF01000003_gene1706	3.951e-10	68.0	COG3166@1|root,COG3166@2|Bacteria,3Y4GJ@57723|Acidobacteria	57723|Acidobacteria	NU	PFAM Fimbrial assembly family protein	-	-	-	ko:K02663	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilN
HKD1_k127_1080021_17	1504672.669785010	0.0006931	51.0	COG3266@1|root,COG3391@1|root,COG5297@1|root,COG3266@2|Bacteria,COG3391@2|Bacteria,COG5297@2|Bacteria,1QWRQ@1224|Proteobacteria	1224|Proteobacteria	M	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	ASH,Abhydrolase_3,Cadherin-like,Cadherin_3,TIG,VCBS
HKD1_k127_1080021_14	338966.Ppro_1415	1.224e-06	58.0	COG2165@1|root,COG2165@2|Bacteria,1MZ5I@1224|Proteobacteria,42W3H@68525|delta/epsilon subdivisions,2WRRC@28221|Deltaproteobacteria,43V6V@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Type II secretory pathway, pseudopilin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1080021_7	1408823.AXUS01000002_gene794	5.397e-46	170.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,25RBQ@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_1080021_9	518766.Rmar_1712	1.128e-40	158.0	COG0352@1|root,COG0352@2|Bacteria,4NNFB@976|Bacteroidetes,1FJ8Z@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin,TMP-TENI
HKD1_k127_1080021_1	204669.Acid345_0689	9.887e-129	422.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_1080021_13	497964.CfE428DRAFT_5639	1.153e-07	62.0	COG0745@1|root,COG0745@2|Bacteria	497964.CfE428DRAFT_5639|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1080021_4	1340493.JNIF01000003_gene1300	6.793e-83	287.0	COG1073@1|root,COG1073@2|Bacteria,3Y99D@57723|Acidobacteria	57723|Acidobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	DUF2048
HKD1_k127_1080021_5	324057.Pjdr2_1262	5.83e-62	226.0	COG1613@1|root,COG1613@2|Bacteria,1TS25@1239|Firmicutes,4HEKX@91061|Bacilli,275TN@186822|Paenibacillaceae	91061|Bacilli	P	Sulfate ABC transporter substrate-binding protein	-	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HKD1_k127_1080021_6	1121035.AUCH01000001_gene1959	1.836e-49	186.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2VI3S@28216|Betaproteobacteria,2KV49@206389|Rhodocyclales	206389|Rhodocyclales	P	Sulfate ABC transporter inner membrane subunit CysW	-	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD1_k127_1080021_3	1128421.JAGA01000001_gene2449	9.666e-85	295.0	COG3842@1|root,COG3842@2|Bacteria	2|Bacteria	P	ATPase activity	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran,TOBE_2,TOBE_3
HKD1_k127_1080021_16	421531.IX38_21045	6.996e-05	53.0	2DGDA@1|root,2ZVHU@2|Bacteria,4P82A@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HKD1_k127_1084478_111	1232437.KL662077_gene1904	3.978e-08	54.0	2AEBV@1|root,3146B@2|Bacteria,1PTMA@1224|Proteobacteria,432JB@68525|delta/epsilon subdivisions,2WXR3@28221|Deltaproteobacteria,2MP7D@213118|Desulfobacterales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_96	1121121.KB894298_gene3968	3.739e-23	100.0	2DPM9@1|root,332MQ@2|Bacteria,1VGFB@1239|Firmicutes,4IAYB@91061|Bacilli,273DA@186822|Paenibacillaceae	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_114	591158.SSMG_05501	6.864e-07	51.0	2DSQW@1|root,33H3S@2|Bacteria,2GTIV@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_112	1382359.JIAL01000001_gene2073	3.207e-07	62.0	COG3103@1|root,COG3103@2|Bacteria,3Y3S0@57723|Acidobacteria,2JIYP@204432|Acidobacteriia	204432|Acidobacteriia	T	Sh3 type 3 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SH3_3,SH3_8
HKD1_k127_1084478_117	1123053.AUDG01000068_gene1516	2.538e-05	57.0	COG3975@1|root,COG3975@2|Bacteria	2|Bacteria	-	-	spoIVB	-	3.4.21.116,3.4.24.3	ko:K01387,ko:K06399	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	Peptidase_M61,Peptidase_M9,Peptidase_M9_N
HKD1_k127_1084478_88	153948.NAL212_0016	4.344e-26	123.0	COG1538@1|root,COG1538@2|Bacteria,1NEZC@1224|Proteobacteria,2W1WM@28216|Betaproteobacteria,374M8@32003|Nitrosomonadales	28216|Betaproteobacteria	MU	PFAM Outer membrane efflux protein	czcC	-	-	ko:K15725	-	-	-	-	ko00000,ko02000	1.B.17.2.2	-	-	OEP
HKD1_k127_1084478_58	159087.Daro_2627	1.523e-57	215.0	COG0845@1|root,COG0845@2|Bacteria,1MX8W@1224|Proteobacteria,2VJNH@28216|Betaproteobacteria	28216|Betaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
HKD1_k127_1084478_0	330214.NIDE3251	2.492e-273	875.0	COG3696@1|root,COG3696@2|Bacteria	2|Bacteria	P	silver ion transport	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
HKD1_k127_1084478_120	240016.ABIZ01000001_gene988	0.0006651	42.0	COG1943@1|root,COG1943@2|Bacteria,46VP6@74201|Verrucomicrobia,2IVSQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_1084478_7	1267534.KB906756_gene278	1.776e-185	594.0	COG0138@1|root,COG0138@2|Bacteria,3Y2QI@57723|Acidobacteria,2JHSU@204432|Acidobacteriia	204432|Acidobacteriia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD1_k127_1084478_87	269798.CHU_0267	5.154e-27	120.0	2CIQE@1|root,2ZR1N@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_92	56107.Cylst_1484	9.877e-25	108.0	COG3755@1|root,COG3755@2|Bacteria,1G8KQ@1117|Cyanobacteria,1HP2U@1161|Nostocales	1117|Cyanobacteria	S	Pfam:DUF1311	-	-	-	-	-	-	-	-	-	-	-	-	LprI
HKD1_k127_1084478_33	1382359.JIAL01000001_gene1578	9.258e-95	317.0	COG0623@1|root,COG0623@2|Bacteria,3Y3EN@57723|Acidobacteria,2JHZZ@204432|Acidobacteriia	204432|Acidobacteriia	I	Enoyl- acyl-carrier-protein reductase NADH	-	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_1084478_39	485913.Krac_0954	4.897e-84	286.0	COG1611@1|root,COG1611@2|Bacteria,2G6IB@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_1084478_98	757424.Hsero_0142	1.335e-22	103.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2VUC8@28216|Betaproteobacteria,474VY@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	tolerance protein	cutA	GO:0003674,GO:0005488,GO:0005507,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0043167,GO:0043169,GO:0044424,GO:0044464,GO:0046872,GO:0046914	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD1_k127_1084478_109	1499967.BAYZ01000036_gene2434	1.294e-08	62.0	COG2260@1|root,COG2260@2|Bacteria	2|Bacteria	J	snoRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	DUF2007
HKD1_k127_1084478_26	469383.Cwoe_1095	4.109e-111	366.0	COG0524@1|root,COG0524@2|Bacteria,2HPJD@201174|Actinobacteria,4CQWU@84995|Rubrobacteria	84995|Rubrobacteria	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD1_k127_1084478_22	1267535.KB906767_gene5475	2.072e-123	402.0	COG0005@1|root,COG0005@2|Bacteria,3Y2MA@57723|Acidobacteria,2JI5Q@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S- adenosylmethionine. Has broad substrate specificity with 6- aminopurine nucleosides as preferred substrates	mtnP	-	2.4.2.28	ko:K00772	ko00270,ko01100,map00270,map01100	M00034	R01402	RC00063,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_1084478_50	330214.NIDE3119	4.673e-69	247.0	COG0491@1|root,COG0491@2|Bacteria,3J1C9@40117|Nitrospirae	40117|Nitrospirae	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_1084478_94	1408428.JNJP01000060_gene856	2.557e-24	117.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,42MPK@68525|delta/epsilon subdivisions,2WJM1@28221|Deltaproteobacteria,2M7YN@213115|Desulfovibrionales	28221|Deltaproteobacteria	O	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	nifM	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD1_k127_1084478_71	224325.AF_2218	4.706e-44	163.0	COG0346@1|root,arCOG02706@2157|Archaea,2XY0R@28890|Euryarchaeota,2469B@183980|Archaeoglobi	183980|Archaeoglobi	E	Glyoxalase-like domain	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_1084478_34	204669.Acid345_2365	3.963e-94	319.0	COG1703@1|root,COG1703@2|Bacteria,3Y40X@57723|Acidobacteria,2JHW8@204432|Acidobacteriia	204432|Acidobacteriia	E	ArgK protein	-	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD1_k127_1084478_15	240015.ACP_1025	2.363e-162	519.0	COG1960@1|root,COG1960@2|Bacteria,3Y3T6@57723|Acidobacteria,2JIV6@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_1084478_52	1121468.AUBR01000014_gene2214	6.991e-68	239.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_1084478_64	234267.Acid_6490	8.154e-52	191.0	COG1386@1|root,COG1386@2|Bacteria,3Y3E0@57723|Acidobacteria	57723|Acidobacteria	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD1_k127_1084478_73	696369.KI912183_gene1310	1.227e-43	169.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,2613X@186807|Peptococcaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD1_k127_1084478_25	1192034.CAP_0896	1.311e-114	378.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,42MCV@68525|delta/epsilon subdivisions,2WJI2@28221|Deltaproteobacteria,2YV60@29|Myxococcales	28221|Deltaproteobacteria	J	tRNA synthetases class I (W and Y)	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD1_k127_1084478_76	1047013.AQSP01000083_gene1194	3.513e-38	152.0	COG1994@1|root,COG1994@2|Bacteria,2NPQP@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	ywhC	-	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M50
HKD1_k127_1084478_41	1382359.JIAL01000001_gene2793	3.973e-81	282.0	COG2133@1|root,COG2133@2|Bacteria,3Y98P@57723|Acidobacteria,2JP56@204432|Acidobacteriia	204432|Acidobacteriia	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_17	177437.HRM2_18590	4.551e-147	485.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,42NA6@68525|delta/epsilon subdivisions,2WIMU@28221|Deltaproteobacteria,2MJ6H@213118|Desulfobacterales	28221|Deltaproteobacteria	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_1084478_43	1120973.AQXL01000120_gene823	1.364e-77	280.0	COG1480@1|root,COG1480@2|Bacteria,1TR1A@1239|Firmicutes,4HAEZ@91061|Bacilli,277ZH@186823|Alicyclobacillaceae	91061|Bacilli	S	7TM receptor with intracellular metal dependent phosphohydrolase	yqfF	-	-	ko:K07037	-	-	-	-	ko00000	-	-	-	7TM-7TMR_HD,7TMR-HDED,HD
HKD1_k127_1084478_61	234267.Acid_4300	1.028e-52	190.0	COG0537@1|root,COG0537@2|Bacteria,3Y4CN@57723|Acidobacteria	57723|Acidobacteria	FG	PFAM Histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HKD1_k127_1084478_84	1131269.AQVV01000005_gene412	2.133e-29	119.0	COG0776@1|root,COG0776@2|Bacteria	2|Bacteria	L	regulation of translation	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_1084478_4	204669.Acid345_4661	1.397e-198	636.0	COG0539@1|root,COG0539@2|Bacteria,3Y3DA@57723|Acidobacteria,2JHS3@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein S1	-	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD1_k127_1084478_113	1499967.BAYZ01000032_gene1143	3.435e-07	64.0	COG1512@1|root,COG1512@2|Bacteria	2|Bacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_1084478_35	926566.Terro_1501	6.471e-94	337.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Pep_M12B_propep,Reprolysin_5,Sortilin-Vps10
HKD1_k127_1084478_105	204669.Acid345_3272	3.25e-10	74.0	COG2885@1|root,COG2885@2|Bacteria,3Y310@57723|Acidobacteria,2JI18@204432|Acidobacteriia	204432|Acidobacteriia	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_1084478_9	204669.Acid345_4115	1.055e-177	566.0	COG0334@1|root,COG0334@2|Bacteria,3Y3B4@57723|Acidobacteria,2JI4Q@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_1084478_8	204669.Acid345_1052	6.222e-183	602.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_1084478_108	351160.LRC308	9.843e-09	68.0	COG0457@1|root,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_1084478_107	485913.Krac_12159	1.651e-09	66.0	COG1716@1|root,COG1716@2|Bacteria	2|Bacteria	T	histone H2A K63-linked ubiquitination	-	-	-	-	-	-	-	-	-	-	-	-	DZR,FHA,zinc_ribbon_2
HKD1_k127_1084478_49	1183438.GKIL_2285	4.037e-75	267.0	COG0400@1|root,COG0400@2|Bacteria,1G3RX@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM phospholipase Carboxylesterase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_2,Esterase
HKD1_k127_1084478_59	517418.Ctha_1405	4.162e-56	214.0	COG4591@1|root,COG4591@2|Bacteria,1FECJ@1090|Chlorobi	1090|Chlorobi	M	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_1084478_101	398767.Glov_0048	1.084e-16	87.0	COG2365@1|root,COG2365@2|Bacteria,1N0NB@1224|Proteobacteria,43CF8@68525|delta/epsilon subdivisions,2X60D@28221|Deltaproteobacteria,43UY8@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Dual specificity phosphatase, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Y_phosphatase2
HKD1_k127_1084478_55	234267.Acid_0084	6.741e-63	230.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_70	765420.OSCT_2858	1.158e-44	177.0	COG0515@1|root,COG0515@2|Bacteria,2GACY@200795|Chloroflexi,375GK@32061|Chloroflexia	32061|Chloroflexia	KLT	SMART tyrosine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD1_k127_1084478_110	864702.OsccyDRAFT_2580	3.734e-08	62.0	COG3409@1|root,COG3409@2|Bacteria,1GR82@1117|Cyanobacteria,1HIA0@1150|Oscillatoriales	1117|Cyanobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_28	485918.Cpin_4074	1.828e-103	343.0	COG2321@1|root,COG2321@2|Bacteria,4NDTZ@976|Bacteroidetes,1INUC@117747|Sphingobacteriia	976|Bacteroidetes	S	Neutral zinc metallopeptidase	ypfJ	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD1_k127_1084478_1	234267.Acid_0085	1.036e-242	763.0	COG1132@1|root,COG1132@2|Bacteria,3Y6PT@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HKD1_k127_1084478_3	1303518.CCALI_00492	9.109e-201	647.0	COG0855@1|root,COG0855@2|Bacteria	2|Bacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_1084478_75	448385.sce7093	9.253e-41	158.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2YVU0@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_1084478_81	886293.Sinac_3837	1.08e-33	140.0	COG0637@1|root,COG0637@2|Bacteria,2J0A7@203682|Planctomycetes	203682|Planctomycetes	S	TIGRFAM haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED	-	-	5.4.2.6	ko:K01838	ko00500,map00500	-	R02728,R11310	RC00408	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_1084478_56	497964.CfE428DRAFT_2318	6.985e-61	220.0	COG0664@1|root,COG4420@1|root,COG0664@2|Bacteria,COG4420@2|Bacteria,46T5T@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003,cNMP_binding
HKD1_k127_1084478_53	1128421.JAGA01000001_gene2241	7.676e-66	232.0	COG1136@1|root,COG1136@2|Bacteria,2NP53@2323|unclassified Bacteria	2|Bacteria	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1084478_24	1205680.CAKO01000002_gene2352	4.422e-115	394.0	COG2114@1|root,COG2114@2|Bacteria,1NAJG@1224|Proteobacteria,2TSVT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HKD1_k127_1084478_68	1340493.JNIF01000003_gene1773	1.685e-46	173.0	COG1143@1|root,COG1143@2|Bacteria,3Y371@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HKD1_k127_1084478_116	1370125.AUWT01000051_gene754	2.418e-06	57.0	2EGCD@1|root,33A46@2|Bacteria,2HHAC@201174|Actinobacteria,239WD@1762|Mycobacteriaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4190)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4190
HKD1_k127_1084478_63	1232410.KI421424_gene1665	2.68e-52	188.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,42RIR@68525|delta/epsilon subdivisions,2WP3R@28221|Deltaproteobacteria,43SGP@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	NDK	ndk	GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006165,GO:0006220,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009987,GO:0015949,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0034641,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046939,GO:0055086,GO:0071704,GO:0072521,GO:0072527,GO:1901360,GO:1901564	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_1084478_103	926566.Terro_0062	5.735e-13	79.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria,2JI38@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM TonB	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_1084478_21	682795.AciX8_0622	3.058e-130	421.0	COG0074@1|root,COG0074@2|Bacteria,3Y3UX@57723|Acidobacteria,2JHSN@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD1_k127_1084478_78	395961.Cyan7425_0783	3.489e-37	154.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G7ID@1117|Cyanobacteria,3KHZI@43988|Cyanothece	1117|Cyanobacteria	O	Peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,TPR_1,TPR_11,TPR_8,Trypsin_2
HKD1_k127_1084478_19	215803.DB30_8025	1.457e-142	466.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,42N91@68525|delta/epsilon subdivisions,2WIMM@28221|Deltaproteobacteria,2YUD9@29|Myxococcales	28221|Deltaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD1_k127_1084478_80	443144.GM21_0856	7.443e-34	141.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,42MBR@68525|delta/epsilon subdivisions,2WJ0Z@28221|Deltaproteobacteria,43SFX@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM peptidase M48 Ste24p	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_1238	Peptidase_M48,TPR_14,TPR_16,TPR_19
HKD1_k127_1084478_54	760117.JN27_22600	5.307e-65	233.0	2DVZY@1|root,33XWI@2|Bacteria	2|Bacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_1084478_20	234267.Acid_4533	2.084e-138	453.0	COG1520@1|root,COG1520@2|Bacteria,3Y2H2@57723|Acidobacteria	57723|Acidobacteria	S	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	PQQ_3
HKD1_k127_1084478_102	309801.trd_A0491	3.975e-13	76.0	2EM19@1|root,33EQT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	MauE
HKD1_k127_1084478_40	1123242.JH636436_gene255	2.821e-82	282.0	COG0388@1|root,COG0388@2|Bacteria,2IXKW@203682|Planctomycetes	203682|Planctomycetes	S	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	3.5.1.6	ko:K01431	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R00905,R04666,R08228	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase
HKD1_k127_1084478_11	1267535.KB906767_gene3553	3.259e-169	540.0	COG0045@1|root,COG0045@2|Bacteria,3Y36X@57723|Acidobacteria,2JHR1@204432|Acidobacteriia	204432|Acidobacteriia	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_1084478_85	913865.DOT_4615	5.418e-28	124.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD1_k127_1084478_89	913865.DOT_4615	7.628e-26	119.0	COG2340@1|root,COG2340@2|Bacteria	2|Bacteria	S	peptidase inhibitor activity	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD1_k127_1084478_67	204669.Acid345_1220	5.215e-47	192.0	COG0457@1|root,COG0457@2|Bacteria,3Y6TV@57723|Acidobacteria,2JMCU@204432|Acidobacteriia	204432|Acidobacteriia	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2,TPR_16
HKD1_k127_1084478_12	1123073.KB899242_gene1567	3.582e-166	537.0	2DBJC@1|root,2Z9K5@2|Bacteria,1NQYW@1224|Proteobacteria	1224|Proteobacteria	G	Glycosyl hydrolase family 47	-	-	3.2.1.113	ko:K01230	ko00510,ko00513,ko01100,ko04141,map00510,map00513,map01100,map04141	M00073,M00074	R05982,R06722	-	ko00000,ko00001,ko00002,ko01000,ko04131	-	GH47	-	Glyco_hydro_47
HKD1_k127_1084478_77	1379270.AUXF01000001_gene2135	5.326e-38	149.0	COG3871@1|root,COG3871@2|Bacteria	2|Bacteria	S	Pyridoxamine 5'-phosphate oxidase	ydaG	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	Putative_PNPOx,Pyrid_ox_like
HKD1_k127_1084478_100	1267533.KB906733_gene3398	6.342e-19	99.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_1084478_66	1218075.BAYA01000009_gene2987	2.601e-47	194.0	COG3712@1|root,COG3712@2|Bacteria,1N941@1224|Proteobacteria,2VIKR@28216|Betaproteobacteria,1K3RG@119060|Burkholderiaceae	28216|Betaproteobacteria	PT	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD1_k127_1084478_44	292415.Tbd_2707	1.621e-77	265.0	COG1272@1|root,COG1272@2|Bacteria,1PGRH@1224|Proteobacteria,2VJR4@28216|Betaproteobacteria,1KT5D@119069|Hydrogenophilales	119069|Hydrogenophilales	S	Haemolysin-III related	-	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD1_k127_1084478_14	682795.AciX8_1960	8.22e-165	531.0	COG0160@1|root,COG0160@2|Bacteria,3Y3P2@57723|Acidobacteria,2JIZJ@204432|Acidobacteriia	204432|Acidobacteriia	E	Aminotransferase class-III	-	-	2.6.1.19	ko:K00823	ko00250,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1084478_82	1324957.K933_14713	9.167e-33	134.0	COG2258@1|root,arCOG11383@2157|Archaea,2XXK8@28890|Euryarchaeota,23VKF@183963|Halobacteria	183963|Halobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD1_k127_1084478_27	671143.DAMO_2531	3.355e-105	352.0	COG0533@1|root,COG0533@2|Bacteria,2NNXP@2323|unclassified Bacteria	2|Bacteria	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	GO:0000287,GO:0000408,GO:0002949,GO:0003674,GO:0003824,GO:0004175,GO:0004222,GO:0005488,GO:0005506,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006508,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008233,GO:0008237,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0019538,GO:0032991,GO:0034470,GO:0034641,GO:0034660,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046914,GO:0070011,GO:0070525,GO:0071704,GO:0090304,GO:0140030,GO:0140032,GO:0140096,GO:1901360,GO:1901564	2.3.1.234	ko:K01409,ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	R10648	RC00070,RC00416	ko00000,ko00001,ko00002,ko01000,ko02044,ko03016	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Peptidase_M22
HKD1_k127_1084478_69	1267534.KB906759_gene1917	1.732e-46	174.0	COG0742@1|root,COG0742@2|Bacteria,3Y4K0@57723|Acidobacteria,2JJDW@204432|Acidobacteriia	204432|Acidobacteriia	L	Conserved hypothetical protein 95	-	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth95
HKD1_k127_1084478_72	861299.J421_6107	7.535e-44	164.0	2CIH2@1|root,2ZTG0@2|Bacteria	2|Bacteria	S	Putative lumazine-binding	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
HKD1_k127_1084478_46	861299.J421_6089	1.011e-76	270.0	COG1073@1|root,COG1680@1|root,COG1073@2|Bacteria,COG1680@2|Bacteria,1ZU86@142182|Gemmatimonadetes	2|Bacteria	V	Domain of unknown function (DUF3471)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Beta-lactamase,DUF3471,Hydrolase_4
HKD1_k127_1084478_13	1541065.JRFE01000022_gene3886	2.587e-165	542.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,3VIJ3@52604|Pleurocapsales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS_3,PAS_9
HKD1_k127_1084478_10	1232410.KI421413_gene599	8.382e-175	578.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,42NF8@68525|delta/epsilon subdivisions,2WKBA@28221|Deltaproteobacteria,43TAY@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_1084478_60	1379270.AUXF01000001_gene2349	5.541e-53	190.0	28NYH@1|root,2ZBVN@2|Bacteria,1ZTSS@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Disulphide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Disulph_isomer
HKD1_k127_1084478_93	697303.Thewi_0606	1.483e-24	108.0	COG0802@1|root,COG0802@2|Bacteria,1V6CV@1239|Firmicutes,24MSS@186801|Clostridia,42GXN@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0079, ATPase	ydiB	-	-	ko:K06925	-	-	-	-	ko00000,ko03016	-	-	-	TsaE
HKD1_k127_1084478_36	696281.Desru_0765	5.97e-93	329.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1TNZE@1239|Firmicutes,2480H@186801|Clostridia,260CR@186807|Peptococcaceae	186801|Clostridia	H	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136,5.1.99.6	ko:K17758,ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	ACPS,Carb_kinase,YjeF_N
HKD1_k127_1084478_99	1054213.HMPREF9946_02411	2.982e-22	113.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,2JPGH@204441|Rhodospirillales	204441|Rhodospirillales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_1084478_37	864051.BurJ1DRAFT_2047	8.585e-88	321.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VWI8@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_1084478_30	518766.Rmar_2028	6.033e-100	362.0	COG0457@1|root,COG3829@1|root,COG0457@2|Bacteria,COG3829@2|Bacteria,4PM5Y@976|Bacteroidetes,1FIME@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_1084478_6	234267.Acid_1531	5.822e-187	601.0	COG0728@1|root,COG0728@2|Bacteria,3Y6N1@57723|Acidobacteria	57723|Acidobacteria	S	MviN-like protein	-	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD1_k127_1084478_16	204669.Acid345_1588	2.657e-154	503.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JKV3@204432|Acidobacteriia	204432|Acidobacteriia	T	Bacterial regulatory protein, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1084478_42	671143.DAMO_2120	1.585e-80	293.0	COG0745@1|root,COG2202@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2NQ9F@2323|unclassified Bacteria	2|Bacteria	T	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_1084478_65	41431.PCC8801_1807	7e-48	192.0	COG2027@1|root,COG2027@2|Bacteria,1G06E@1117|Cyanobacteria,3KGY1@43988|Cyanothece	1117|Cyanobacteria	M	PFAM peptidase S13 D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD1_k127_1084478_79	374847.Kcr_1173	1.588e-34	140.0	COG1059@1|root,arCOG04357@2157|Archaea	2157|Archaea	L	Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites)	ogg	-	4.2.99.18	ko:K03653	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_1084478_118	580332.Slit_0580	0.0001164	55.0	COG0457@1|root,COG4976@1|root,COG0457@2|Bacteria,COG4976@2|Bacteria,1RAIT@1224|Proteobacteria,2VN0T@28216|Betaproteobacteria	28216|Betaproteobacteria	S	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,TPR_1,TPR_10,TPR_11,TPR_14,TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_1084478_106	1183438.GKIL_4114	1.281e-09	71.0	COG3577@1|root,COG3577@2|Bacteria,1G044@1117|Cyanobacteria	1117|Cyanobacteria	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	gag-asp_proteas
HKD1_k127_1084478_95	388467.A19Y_2179	1.531e-23	107.0	COG1848@1|root,COG1848@2|Bacteria,1G51H@1117|Cyanobacteria,1HAWH@1150|Oscillatoriales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_1084478_91	478741.JAFS01000002_gene528	8.289e-25	111.0	COG0741@1|root,COG0741@2|Bacteria,46W79@74201|Verrucomicrobia,37GKP@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Transglycosylase SLT domain	mltE	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD1_k127_1084478_83	1122917.KB899665_gene4164	3.652e-31	130.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,4HC2G@91061|Bacilli,26R4Z@186822|Paenibacillaceae	91061|Bacilli	S	MgtC SapB transporter	mgtC3	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
HKD1_k127_1084478_29	1379270.AUXF01000004_gene3236	3.674e-102	347.0	COG0402@1|root,COG0402@2|Bacteria,1ZSMH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31,3.5.4.40	ko:K12960,ko:K20810	ko00130,ko00270,ko01100,ko01110,map00130,map00270,map01100,map01110	-	R09660,R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1084478_23	204669.Acid345_3242	5.305e-123	404.0	COG0484@1|root,COG0484@2|Bacteria,3Y33I@57723|Acidobacteria,2JIBF@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_1084478_2	706587.Desti_1689	7.194e-230	726.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,42M64@68525|delta/epsilon subdivisions,2WIWS@28221|Deltaproteobacteria,2MR7D@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_1084478_86	1430331.EP10_05355	8.171e-28	122.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,4HIRK@91061|Bacilli,1WG1T@129337|Geobacillus	91061|Bacilli	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	GO:0000166,GO:0000774,GO:0001871,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0008150,GO:0009986,GO:0017076,GO:0030234,GO:0030246,GO:0030247,GO:0030554,GO:0036094,GO:0044464,GO:0050790,GO:0051082,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0097159,GO:0098772,GO:1901265,GO:1901363,GO:2001065	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_1084478_51	671143.DAMO_2256	2.562e-68	245.0	COG1420@1|root,COG1420@2|Bacteria,2NPAK@2323|unclassified Bacteria	2|Bacteria	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HTH_DeoR,HrcA,HrcA_DNA-bdg
HKD1_k127_1084478_62	1382359.JIAL01000001_gene123	1.221e-52	196.0	COG1451@1|root,COG1451@2|Bacteria,3Y2SM@57723|Acidobacteria,2JHKB@204432|Acidobacteriia	204432|Acidobacteriia	S	nucleotide metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1084478_47	861299.J421_3685	1.115e-76	260.0	COG0231@1|root,COG0231@2|Bacteria,1ZT2N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD1_k127_1084478_45	204669.Acid345_4718	3.338e-77	275.0	COG1519@1|root,COG1519@2|Bacteria,3Y3X5@57723|Acidobacteria,2JI61@204432|Acidobacteriia	204432|Acidobacteriia	M	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase)	-	-	2.4.99.12,2.4.99.13,2.4.99.14,2.4.99.15	ko:K02527	ko00540,ko01100,map00540,map01100	M00060,M00080	R04658,R05074,R09763	RC00009,RC00077,RC00247	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT30	-	Glycos_transf_N
HKD1_k127_1084478_57	382464.ABSI01000010_gene3398	2.217e-59	219.0	COG1663@1|root,COG1663@2|Bacteria,46SBI@74201|Verrucomicrobia,2ITPT@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA)	lpxK	-	2.7.1.130	ko:K00912	ko00540,ko01100,map00540,map01100	M00060	R04657	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxK
HKD1_k127_1084478_48	379066.GAU_3864	2.456e-76	276.0	COG0515@1|root,COG3170@1|root,COG0515@2|Bacteria,COG3170@2|Bacteria,1ZTGA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_1084478_104	1192034.CAP_1790	7.057e-11	68.0	COG0636@1|root,COG0636@2|Bacteria,1QAIF@1224|Proteobacteria,43A8Y@68525|delta/epsilon subdivisions,2X9Z1@28221|Deltaproteobacteria,2YW38@29|Myxococcales	28221|Deltaproteobacteria	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD1_k127_1084478_74	1340493.JNIF01000003_gene3632	2.838e-42	167.0	COG0356@1|root,COG0356@2|Bacteria,3Y4CM@57723|Acidobacteria	57723|Acidobacteria	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD1_k127_1084478_38	373903.Hore_14640	7.436e-87	298.0	COG0330@1|root,COG0330@2|Bacteria,1W711@1239|Firmicutes,25IRK@186801|Clostridia,3WC5Y@53433|Halanaerobiales	186801|Clostridia	O	prohibitin homologues	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_1084478_31	1267534.KB906754_gene2899	2.198e-96	332.0	COG0154@1|root,COG0154@2|Bacteria,3Y41H@57723|Acidobacteria,2JKKU@204432|Acidobacteriia	204432|Acidobacteriia	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD1_k127_1084478_5	1094980.Mpsy_0534	2.158e-195	633.0	COG1063@1|root,arCOG01621@2157|Archaea,2XTZT@28890|Euryarchaeota,2NAI1@224756|Methanomicrobia	224756|Methanomicrobia	E	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_zinc_N,GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_1084478_18	682795.AciX8_1289	3.877e-143	460.0	COG0039@1|root,COG0039@2|Bacteria,3Y2PG@57723|Acidobacteria,2JII1@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_1086117_12	706587.Desti_1655	0.0005763	44.0	COG1943@1|root,COG1943@2|Bacteria,1NA94@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_1086117_7	1121904.ARBP01000004_gene925	2.694e-77	276.0	COG3386@1|root,COG3386@2|Bacteria,4PKKP@976|Bacteroidetes,47RQ5@768503|Cytophagia	976|Bacteroidetes	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HKD1_k127_1086117_1	1499967.BAYZ01000154_gene1470	2.422e-128	425.0	COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
HKD1_k127_1086117_10	1254432.SCE1572_29320	4.485e-57	203.0	COG2259@1|root,COG2259@2|Bacteria,1PT6T@1224|Proteobacteria,434W0@68525|delta/epsilon subdivisions,2WZ73@28221|Deltaproteobacteria,2Z1GN@29|Myxococcales	28221|Deltaproteobacteria	S	DoxX	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD1_k127_1086117_8	395964.KE386496_gene1500	7.303e-76	262.0	COG3945@1|root,COG3945@2|Bacteria,1NX3S@1224|Proteobacteria,2U1MQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_1086117_11	221288.JH992901_gene1687	1.28e-38	146.0	COG1695@1|root,COG1695@2|Bacteria,1GDRG@1117|Cyanobacteria	1117|Cyanobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD1_k127_1086117_5	234267.Acid_5886	1.189e-115	389.0	COG1538@1|root,COG1538@2|Bacteria,3Y3KB@57723|Acidobacteria	57723|Acidobacteria	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_1086117_0	234267.Acid_5518	0.0	1229.0	COG0841@1|root,COG0841@2|Bacteria,3Y478@57723|Acidobacteria	57723|Acidobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_1086117_6	1267535.KB906767_gene2008	2.116e-94	326.0	COG0845@1|root,COG0845@2|Bacteria,3Y2U2@57723|Acidobacteria,2JMFW@204432|Acidobacteriia	204432|Acidobacteriia	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_1086117_9	485913.Krac_9565	1.093e-64	224.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_1086117_2	63737.Npun_R2975	4.416e-127	413.0	28IG1@1|root,2Z8HJ@2|Bacteria,1G0EA@1117|Cyanobacteria,1HJM2@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1086117_4	504472.Slin_4173	2.947e-116	389.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,47M3Z@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1086117_3	1254432.SCE1572_13755	2.59e-126	409.0	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,433XH@68525|delta/epsilon subdivisions,2X2FU@28221|Deltaproteobacteria,2YXR6@29|Myxococcales	28221|Deltaproteobacteria	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD1_k127_1099284_2	616991.JPOO01000003_gene1700	5.509e-226	709.0	COG1140@1|root,COG1140@2|Bacteria	2|Bacteria	C	nitrate reductase beta subunit	narH	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0033554,GO:0042126,GO:0043436,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050896,GO:0051536,GO:0051538,GO:0051539,GO:0051540,GO:0051716,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	iAF987.Gmet_1021,iEcE24377_1341.EcE24377A_1376,iEcolC_1368.EcolC_2189	Fer4_11,Nitr_red_bet_C
HKD1_k127_1099284_0	1121920.AUAU01000008_gene1619	0.0	1791.0	COG5013@1|root,COG5013@2|Bacteria	2|Bacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	narG	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006082,GO:0006091,GO:0006807,GO:0008150,GO:0008152,GO:0008940,GO:0009055,GO:0009061,GO:0009325,GO:0009898,GO:0009987,GO:0015980,GO:0016020,GO:0016021,GO:0016491,GO:0016661,GO:0019645,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0031235,GO:0032991,GO:0042126,GO:0043436,GO:0043546,GO:0044237,GO:0044281,GO:0044425,GO:0044459,GO:0044464,GO:0044799,GO:0045333,GO:0048037,GO:0050662,GO:0051536,GO:0051539,GO:0051540,GO:0055114,GO:0070469,GO:0070470,GO:0071704,GO:0071944,GO:0097159,GO:0098552,GO:0098562,GO:0098796,GO:0098797,GO:0098803,GO:1901363,GO:1902494,GO:1990204,GO:2001057	1.7.5.1	ko:K00370,ko:K17050	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.8	-	iSBO_1134.SBO_1842,iUMN146_1321.UM146_09685	Molybdopterin,Molydop_binding,Nitr_red_alph_N
HKD1_k127_1099284_32	1121920.AUAU01000008_gene1620	3.704e-45	175.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	iAF987.Gmet_0328	Cytochrom_C,Cytochrome_CBB3
HKD1_k127_1099284_39	1125863.JAFN01000001_gene202	3.713e-21	98.0	COG1959@1|root,COG1959@2|Bacteria,1MZ1C@1224|Proteobacteria,42SPF@68525|delta/epsilon subdivisions,2WPVC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	TIGRFAM transcriptional regulator, Rrf2 family	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_1099284_37	266117.Rxyl_3086	4.231e-24	110.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	ahyR	-	-	ko:K07782,ko:K15852	ko02020,ko02024,ko02026,map02020,map02024,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
HKD1_k127_1099284_28	909663.KI867150_gene69	1.412e-51	190.0	arCOG11509@1|root,31KIR@2|Bacteria,1RGVE@1224|Proteobacteria,42T74@68525|delta/epsilon subdivisions,2WPQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1099284_31	234267.Acid_2934	2.27e-45	170.0	COG3945@1|root,COG3945@2|Bacteria,3Y5T8@57723|Acidobacteria	57723|Acidobacteria	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_1099284_36	358396.C445_00165	1.132e-25	110.0	COG0599@1|root,arCOG02148@2157|Archaea,2XXZ4@28890|Euryarchaeota,23W39@183963|Halobacteria	183963|Halobacteria	S	gamma-carboxymuconolactone decarboxylase subunit	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_1099284_21	204669.Acid345_1821	8.701e-99	331.0	COG0540@1|root,COG0540@2|Bacteria,3Y7K1@57723|Acidobacteria,2JMQX@204432|Acidobacteriia	204432|Acidobacteriia	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_1099284_19	204669.Acid345_1820	5.326e-103	343.0	COG0549@1|root,COG0549@2|Bacteria,3Y7CP@57723|Acidobacteria	57723|Acidobacteria	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_1099284_12	941824.TCEL_00051	1.833e-157	505.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,36G77@31979|Clostridiaceae	186801|Clostridia	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_1099284_5	1499967.BAYZ01000188_gene3892	9.197e-195	618.0	COG0031@1|root,COG0031@2|Bacteria,2NNZI@2323|unclassified Bacteria	2|Bacteria	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47,6.2.1.30	ko:K01738,ko:K01912	ko00270,ko00360,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko05111,map00270,map00360,map00920,map01100,map01110,map01120,map01130,map01200,map01230,map05111	M00021	R00897,R02539,R03601,R04859	RC00004,RC00014,RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_1099284_7	941824.TCEL_00052	3e-170	543.0	COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,249P4@186801|Clostridia,36F9U@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the ATCase OTCase family	ygeW	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
HKD1_k127_1099284_1	502025.Hoch_4147	8.914e-310	971.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1MUEA@1224|Proteobacteria,42MER@68525|delta/epsilon subdivisions,2WIYV@28221|Deltaproteobacteria,2YW7P@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HKD1_k127_1099284_10	1187851.A33M_2209	4.925e-168	551.0	COG0167@1|root,COG0479@1|root,COG0167@2|Bacteria,COG0479@2|Bacteria,1PHK0@1224|Proteobacteria,2UQYP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CF	dihydroorotate dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1099284_20	196162.Noca_1629	7.565e-101	343.0	COG0402@1|root,COG0402@2|Bacteria,2ISY0@201174|Actinobacteria	201174|Actinobacteria	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_1099284_15	891968.Anamo_1362	1.621e-134	440.0	COG0498@1|root,COG0498@2|Bacteria,3TA4S@508458|Synergistetes	508458|Synergistetes	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_1099284_23	518766.Rmar_1973	4.672e-95	322.0	COG1878@1|root,COG1878@2|Bacteria,4PIWM@976|Bacteroidetes,1FJPB@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Putative cyclase	-	GO:0003674,GO:0003824,GO:0004061,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HKD1_k127_1099284_14	234267.Acid_5562	1.643e-144	470.0	COG4102@1|root,COG4102@2|Bacteria,3Y2YD@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HKD1_k127_1099284_11	1121015.N789_06360	4.508e-159	526.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,1RSEC@1236|Gammaproteobacteria,1X44S@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HKD1_k127_1099284_35	1123320.KB889687_gene887	8.174e-26	117.0	COG0726@1|root,COG0726@2|Bacteria,2H44A@201174|Actinobacteria	201174|Actinobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_1099284_34	1203611.KB894546_gene213	1.158e-26	119.0	COG0500@1|root,COG2226@2|Bacteria,4NE6P@976|Bacteroidetes	976|Bacteroidetes	Q	Methyltransferase	rebM	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_1099284_13	1068980.ARVW01000001_gene4690	6.014e-147	480.0	COG2234@1|root,COG2234@2|Bacteria,2I9YF@201174|Actinobacteria	201174|Actinobacteria	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_1099284_33	204669.Acid345_4448	7.359e-27	122.0	COG1595@1|root,COG1595@2|Bacteria,3Y7TB@57723|Acidobacteria,2JMZD@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
HKD1_k127_1099284_26	330214.NIDE0244	2.57e-71	249.0	COG0602@1|root,COG0602@2|Bacteria,3J0M2@40117|Nitrospirae	40117|Nitrospirae	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_1099284_25	880073.Calab_2509	4.276e-86	292.0	COG0603@1|root,COG0603@2|Bacteria,2NPD6@2323|unclassified Bacteria	2|Bacteria	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	iAF987.Gmet_3075	QueC
HKD1_k127_1099284_40	1267535.KB906767_gene5189	5.043e-13	81.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_1099284_4	379066.GAU_2733	4.206e-214	707.0	COG0587@1|root,COG0587@2|Bacteria,1ZU9R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Helix-hairpin-helix motif	-	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_1099284_22	234267.Acid_7036	3.033e-98	338.0	COG0389@1|root,COG0389@2|Bacteria,3Y3EV@57723|Acidobacteria	57723|Acidobacteria	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HKD1_k127_1099284_30	234267.Acid_7037	2.906e-48	183.0	COG0468@1|root,COG0468@2|Bacteria,3Y4QB@57723|Acidobacteria	57723|Acidobacteria	L	recA bacterial DNA recombination protein	-	-	-	-	-	-	-	-	-	-	-	-	RecA
HKD1_k127_1099284_24	404589.Anae109_2572	5.516e-87	291.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,42ZZ6@68525|delta/epsilon subdivisions,2WV5A@28221|Deltaproteobacteria,2YZAW@29|Myxococcales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_1099284_29	379066.GAU_1726	4.87e-49	183.0	COG1974@1|root,COG1974@2|Bacteria,1ZSSM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD1_k127_1099284_3	1121920.AUAU01000016_gene1339	2.318e-221	701.0	COG2804@1|root,COG2804@2|Bacteria,3Y2IS@57723|Acidobacteria	57723|Acidobacteria	NU	Type II secretion system (T2SS), protein E, N-terminal domain	-	-	-	ko:K02454	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	T2SSE,T2SSE_N
HKD1_k127_1099284_8	204669.Acid345_1391	6.287e-170	541.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_1099284_16	204669.Acid345_1390	3.752e-128	421.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	2|Bacteria	NU	PFAM Type II secretion system F domain	pilC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD1_k127_1099284_18	880073.Calab_2000	8.775e-106	352.0	COG0451@1|root,COG0451@2|Bacteria,2NNNX@2323|unclassified Bacteria	2|Bacteria	GM	NAD(P)H-binding	wbpP	-	5.1.3.2,5.1.3.7	ko:K01784,ko:K02473	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R00418,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_1099284_9	667014.Thein_1210	1.283e-169	542.0	COG1004@1|root,COG1004@2|Bacteria,2GGQN@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_1099284_17	941824.TCEL_01798	8.697e-112	376.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,36DPK@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_1099284_27	269799.Gmet_2671	5.921e-63	226.0	COG1573@1|root,COG1573@2|Bacteria,1MWX1@1224|Proteobacteria,42QXV@68525|delta/epsilon subdivisions,2WMXB@28221|Deltaproteobacteria,43TTD@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	Uracil DNA glycosylase superfamily	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_1099284_6	234267.Acid_0690	1.411e-194	634.0	COG1198@1|root,COG1198@2|Bacteria,3Y2NY@57723|Acidobacteria	57723|Acidobacteria	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_1099284_38	1340493.JNIF01000003_gene2089	9.769e-24	102.0	COG1629@1|root,COG1629@2|Bacteria,3Y67H@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_111006_23	204669.Acid345_3218	3.695e-60	239.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria,2JKBG@204432|Acidobacteriia	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_111006_33	1385935.N836_30695	1.858e-12	82.0	COG2133@1|root,COG2755@1|root,COG2133@2|Bacteria,COG2755@2|Bacteria,1G70I@1117|Cyanobacteria	1117|Cyanobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_111006_16	756067.MicvaDRAFT_5451	1.013e-75	291.0	COG1361@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
HKD1_k127_111006_31	204669.Acid345_2450	3.209e-20	108.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Collagen,fn3
HKD1_k127_111006_15	1147.D082_25660	1.928e-79	304.0	COG2931@1|root,COG3204@1|root,COG3210@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,1G5KY@1117|Cyanobacteria,1H6DE@1142|Synechocystis	1117|Cyanobacteria	QU	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,HemolysinCabind,VCBS
HKD1_k127_111006_29	449447.MAE_12430	1.241e-22	116.0	COG1404@1|root,COG2931@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,1G04W@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM Proprotein convertase P-domain	prcA	-	-	-	-	-	-	-	-	-	-	-	P_proprotein,Peptidase_S8
HKD1_k127_111006_30	682795.AciX8_1449	3.725e-22	115.0	COG3391@1|root,COG3391@2|Bacteria,3Y55M@57723|Acidobacteria	57723|Acidobacteria	S	Polymorphic membrane protein, Chlamydia	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_111006_25	234267.Acid_1930	6.967e-58	231.0	COG1629@1|root,COG1629@2|Bacteria,3Y3G2@57723|Acidobacteria	57723|Acidobacteria	P	PFAM TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_111006_10	395963.Bind_2528	1.12e-103	347.0	COG1388@1|root,COG1388@2|Bacteria,1MY1S@1224|Proteobacteria,2TVJ0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Domain of Unknown Function (DUF1259)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1529
HKD1_k127_111006_13	1196031.ALEG01000039_gene1395	4.61e-96	325.0	COG2423@1|root,COG2423@2|Bacteria,1TPHM@1239|Firmicutes,4IRCI@91061|Bacilli,1ZNCI@1386|Bacillus	91061|Bacilli	E	Ornithine cyclodeaminase/mu-crystallin family	sbnB	-	1.5.1.51	ko:K21721	-	-	-	-	ko00000,ko01000	-	-	iSB619.SA_RS00720	OCD_Mu_crystall
HKD1_k127_111006_14	7739.XP_002596423.1	8.501e-83	281.0	COG3340@1|root,2QR7X@2759|Eukaryota,39DGA@33154|Opisthokonta,3BC18@33208|Metazoa,3CWYN@33213|Bilateria,484TW@7711|Chordata	33208|Metazoa	E	Peptidase family S51	-	GO:0003674,GO:0003824,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0016787,GO:0019538,GO:0043170,GO:0044238,GO:0071704,GO:0140096,GO:1901564	3.4.13.21	ko:K05995	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S51
HKD1_k127_111006_19	1286106.MPL1_11368	5.358e-70	252.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,1RPNP@1236|Gammaproteobacteria,4605N@72273|Thiotrichales	72273|Thiotrichales	P	Chromate transporter	-	-	-	-	-	-	-	-	-	-	-	-	Chromate_transp
HKD1_k127_111006_18	1380394.JADL01000009_gene3374	5.315e-70	250.0	COG4275@1|root,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TV61@28211|Alphaproteobacteria,2JVSA@204441|Rhodospirillales	204441|Rhodospirillales	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist
HKD1_k127_111006_22	443144.GM21_0397	1.084e-60	224.0	COG3005@1|root,COG3005@2|Bacteria,1R4UP@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome C family protein	mtrA	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,Paired_CXXCH_1
HKD1_k127_111006_24	443144.GM21_0398	5.485e-58	229.0	COG3637@1|root,COG3637@2|Bacteria	2|Bacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	Ail_Lom,MtrB_PioB
HKD1_k127_111006_28	1192034.CAP_8237	1.164e-38	167.0	COG0437@1|root,COG0664@1|root,COG0437@2|Bacteria,COG0664@2|Bacteria,1QZTQ@1224|Proteobacteria,43CNM@68525|delta/epsilon subdivisions,2X2C7@28221|Deltaproteobacteria,2YX3F@29|Myxococcales	28221|Deltaproteobacteria	CT	4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_7,cNMP_binding
HKD1_k127_111006_39	459495.SPLC1_S032470	5.856e-05	55.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,1G102@1117|Cyanobacteria,1H919@1150|Oscillatoriales	1117|Cyanobacteria	V	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
HKD1_k127_111006_36	1538295.JY96_13815	5.11e-07	62.0	COG0484@1|root,COG0484@2|Bacteria,1Q629@1224|Proteobacteria,2VJ8G@28216|Betaproteobacteria,1KNFS@119065|unclassified Burkholderiales	28216|Betaproteobacteria	C	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_111006_21	945713.IALB_0800	6.625e-63	235.0	COG0492@1|root,COG1145@1|root,COG0492@2|Bacteria,COG1145@2|Bacteria	2|Bacteria	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	trxB_2	-	1.18.1.2,1.19.1.1,1.8.1.9	ko:K00384,ko:K21567	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Pyr_redox_3
HKD1_k127_111006_40	485915.Dret_1027	0.0004214	50.0	2E17X@1|root,32WNJ@2|Bacteria,1N3GY@1224|Proteobacteria,42TVS@68525|delta/epsilon subdivisions,2WQQD@28221|Deltaproteobacteria,2MCN4@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM cytochrome c class III	tmcA	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD1_k127_111006_35	204669.Acid345_0471	1.292e-07	63.0	COG0484@1|root,COG0484@2|Bacteria	2|Bacteria	O	heat shock protein binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_111006_38	641491.DND132_1541	8.434e-06	58.0	COG0484@1|root,COG0484@2|Bacteria,1R72H@1224|Proteobacteria,42NCE@68525|delta/epsilon subdivisions,2WKDN@28221|Deltaproteobacteria,2M9A6@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	PFAM cytochrome c class III	hmcA	GO:0005575,GO:0005623,GO:0042597,GO:0044464	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD1_k127_111006_1	234267.Acid_1644	0.0	1104.0	COG1629@1|root,COG4771@2|Bacteria,3Y7B4@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_111006_11	666685.R2APBS1_1298	6.674e-100	337.0	COG3391@1|root,COG3391@2|Bacteria,1R736@1224|Proteobacteria,1TBRS@1236|Gammaproteobacteria,1X9A5@135614|Xanthomonadales	135614|Xanthomonadales	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_111006_9	1123073.KB899244_gene250	2.562e-118	390.0	COG0697@1|root,COG0697@2|Bacteria,1N3FA@1224|Proteobacteria,1RYMI@1236|Gammaproteobacteria,1X5QQ@135614|Xanthomonadales	135614|Xanthomonadales	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_111006_8	204669.Acid345_0818	2.643e-125	430.0	COG2091@1|root,COG2091@2|Bacteria,3Y46J@57723|Acidobacteria,2JHWP@204432|Acidobacteriia	204432|Acidobacteriia	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_111006_12	1122604.JONR01000025_gene4602	3.794e-99	348.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_111006_32	234267.Acid_0153	1.846e-18	103.0	COG3391@1|root,COG4625@1|root,COG3391@2|Bacteria,COG4625@2|Bacteria,3Y55M@57723|Acidobacteria	57723|Acidobacteria	S	Polymorphic membrane protein, Chlamydia	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_111006_6	247490.KSU1_C0714	1.084e-163	583.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HKD1_k127_111006_34	313612.L8106_01142	3.053e-10	76.0	COG2373@1|root,COG2931@1|root,COG2373@2|Bacteria,COG2931@2|Bacteria,1G02E@1117|Cyanobacteria,1H9TQ@1150|Oscillatoriales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,HemolysinCabind,SBBP
HKD1_k127_111006_37	866895.HBHAL_4021	8.881e-07	55.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,4HACP@91061|Bacilli,3NDBQ@45667|Halobacillus	91061|Bacilli	E	Histidine biosynthesis protein	hisA	GO:0000105,GO:0000162,GO:0003674,GO:0003824,GO:0003949,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006547,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0016853,GO:0016860,GO:0016861,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0052803,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_111006_3	1242864.D187_004920	6.011e-224	704.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
HKD1_k127_111006_17	240015.ACP_3472	7.773e-73	260.0	COG0583@1|root,COG0583@2|Bacteria,3Y31P@57723|Acidobacteria,2JIC0@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_111006_0	290397.Adeh_0817	0.0	2101.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1MU7B@1224|Proteobacteria,42MF7@68525|delta/epsilon subdivisions,2WJBR@28221|Deltaproteobacteria,2YUAD@29|Myxococcales	28221|Deltaproteobacteria	E	Glutamate synthase	gltB1	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_111006_4	398512.JQKC01000033_gene5009	2.365e-213	672.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,3WGBX@541000|Ruminococcaceae	186801|Clostridia	C	glutamate synthase	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_111006_5	1121406.JAEX01000005_gene3039	3.835e-198	633.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,42M1X@68525|delta/epsilon subdivisions,2WJA2@28221|Deltaproteobacteria,2M9EY@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	TIGRFAM Acetolactate synthase, large subunit, biosynthetic	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_111006_26	1120973.AQXL01000093_gene2301	7.008e-44	166.0	COG0440@1|root,COG0440@2|Bacteria,1V2AJ@1239|Firmicutes,4HHSU@91061|Bacilli,279T2@186823|Alicyclobacillaceae	91061|Bacilli	E	ACT domain	ilvH	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,ACT_5,ALS_ss_C
HKD1_k127_111006_7	1125863.JAFN01000001_gene2480	1.146e-145	469.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,42MRS@68525|delta/epsilon subdivisions,2WJW8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD1_k127_111006_2	533240.CRC_01437	3.523e-276	857.0	COG0129@1|root,COG0129@2|Bacteria,1G0KD@1117|Cyanobacteria,1HITF@1161|Nostocales	1117|Cyanobacteria	EG	Belongs to the IlvD Edd family	ilvD	GO:0003674,GO:0003824,GO:0004160,GO:0016829,GO:0016835,GO:0016836	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_111006_20	1163617.SCD_n00892	6.424e-70	239.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,2VZA1@28216|Betaproteobacteria	28216|Betaproteobacteria	E	PFAM DAHP synthetase I KDSA	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_111006_27	1123368.AUIS01000001_gene1868	5.128e-41	153.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,1S11K@1236|Gammaproteobacteria,2NBQA@225057|Acidithiobacillales	225057|Acidithiobacillales	E	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_1122818_7	1167006.UWK_01777	1.664e-32	145.0	COG0367@1|root,COG0367@2|Bacteria,1R77U@1224|Proteobacteria,4305Y@68525|delta/epsilon subdivisions,2WVE7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_1122818_11	373994.Riv7116_5513	0.0001391	53.0	COG1493@1|root,COG1493@2|Bacteria,1GI2G@1117|Cyanobacteria,1HNR1@1161|Nostocales	1117|Cyanobacteria	T	PFAM HPr Serine kinase C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1122818_8	118168.MC7420_2498	6.317e-25	106.0	COG3751@1|root,COG3751@2|Bacteria,1GGCA@1117|Cyanobacteria	1117|Cyanobacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1122818_9	118168.MC7420_2498	7.36e-18	88.0	COG3751@1|root,COG3751@2|Bacteria,1GGCA@1117|Cyanobacteria	1117|Cyanobacteria	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1122818_6	1173022.Cri9333_4294	1.15e-66	242.0	COG1216@1|root,COG1216@2|Bacteria,1G3T8@1117|Cyanobacteria,1HA4H@1150|Oscillatoriales	1117|Cyanobacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HKD1_k127_1122818_1	234267.Acid_5006	1.923e-261	818.0	COG1472@1|root,COG1472@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 3 family	celD	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	CBM_11,CBM_2,CBM_6,Calx-beta,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_1122818_4	861299.J421_0382	3.785e-130	428.0	COG1940@1|root,COG1940@2|Bacteria,1ZV0J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	GK	ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
HKD1_k127_1122818_0	234267.Acid_2734	0.0	1056.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HKD1_k127_1122818_3	234267.Acid_7221	2.255e-165	530.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HKD1_k127_1122818_5	639030.JHVA01000001_gene600	1.386e-71	249.0	COG1028@1|root,COG1028@2|Bacteria,3Y3YM@57723|Acidobacteria,2JI6U@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_1122818_2	1267534.KB906757_gene1007	2.321e-227	724.0	2C0ZI@1|root,2ZAKK@2|Bacteria	2|Bacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4962,Hepar_II_III
HKD1_k127_1122818_10	709797.CSIRO_1682	1.18e-08	59.0	2EKP5@1|root,33ECX@2|Bacteria,1RD05@1224|Proteobacteria,2TZ3I@28211|Alphaproteobacteria,3K6YE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_1137008_1	357808.RoseRS_1484	4.343e-113	374.0	COG0604@1|root,COG0604@2|Bacteria,2G6KH@200795|Chloroflexi,3763V@32061|Chloroflexia	32061|Chloroflexia	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1137008_0	867845.KI911784_gene567	1.33e-196	626.0	COG1960@1|root,COG1960@2|Bacteria,2G7V8@200795|Chloroflexi,375QJ@32061|Chloroflexia	32061|Chloroflexia	C	PFAM acyl-CoA dehydrogenase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M
HKD1_k127_1137008_2	448385.sce6324	5.853e-81	284.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42M2E@68525|delta/epsilon subdivisions,2WKAB@28221|Deltaproteobacteria,2YWDZ@29|Myxococcales	28221|Deltaproteobacteria	K	Transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat,V4R,XylR_N
HKD1_k127_1137008_3	309801.trd_1057	1.57e-10	69.0	COG0750@1|root,COG0750@2|Bacteria,2G6HV@200795|Chloroflexi,27XS5@189775|Thermomicrobia	189775|Thermomicrobia	M	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD1_k127_1137008_4	879310.HMPREF9162_0476	1.373e-05	56.0	2E382@1|root,32Y7S@2|Bacteria,1VF4Z@1239|Firmicutes,4H5V7@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_28	314230.DSM3645_20387	1.239e-57	207.0	COG0235@1|root,COG0235@2|Bacteria,2J2P1@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P)	mtnB	-	4.2.1.109	ko:K08964	ko00270,ko01100,map00270,map01100	M00034	R07392	RC01939	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase_II
HKD1_k127_1152682_19	1173264.KI913949_gene37	1.63e-67	235.0	COG1791@1|root,COG1791@2|Bacteria,1G274@1117|Cyanobacteria	1117|Cyanobacteria	S	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway	mtnD	-	1.13.11.53,1.13.11.54	ko:K08967	ko00270,ko01100,map00270,map01100	M00034	R07363,R07364	RC01866,RC02018,RC02118	ko00000,ko00001,ko00002,ko01000	-	-	-	ARD
HKD1_k127_1152682_26	1173264.KI913949_gene3008	4.355e-61	222.0	COG4229@1|root,COG4229@2|Bacteria,1G5UV@1117|Cyanobacteria,1HB8J@1150|Oscillatoriales	1117|Cyanobacteria	C	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)	mtnC	-	3.1.3.77	ko:K09880	ko00270,ko01100,map00270,map01100	M00034	R07395	RC02779	ko00000,ko00001,ko00002,ko01000	-	-	-	HAD_2,Hydrolase
HKD1_k127_1152682_35	439235.Dalk_1593	2.283e-35	147.0	COG2267@1|root,COG2267@2|Bacteria,1P3EB@1224|Proteobacteria,42UGM@68525|delta/epsilon subdivisions,2WQR2@28221|Deltaproteobacteria,2MPGU@213118|Desulfobacterales	28221|Deltaproteobacteria	I	PFAM alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_1152682_24	269799.Gmet_1589	7.274e-63	230.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,42MU5@68525|delta/epsilon subdivisions,2WKWY@28221|Deltaproteobacteria,43UI1@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	GO:0001522,GO:0003674,GO:0003824,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016071,GO:0016556,GO:0016853,GO:0016866,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1990481	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C,TruB_C_2,TruB_N
HKD1_k127_1152682_45	234267.Acid_0965	4.044e-10	68.0	COG2137@1|root,COG2137@2|Bacteria,3Y4WT@57723|Acidobacteria	57723|Acidobacteria	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD1_k127_1152682_47	58344.JOEL01000005_gene4323	1.218e-07	63.0	2B9N3@1|root,3230D@2|Bacteria,2H7I7@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_2	1242864.D187_003508	3.036e-254	812.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,42M70@68525|delta/epsilon subdivisions,2WJA8@28221|Deltaproteobacteria,2YU3X@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	GO:0003674,GO:0003824,GO:0004812,GO:0004813,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006412,GO:0006418,GO:0006419,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016597,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0031406,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0036094,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043170,GO:0043177,GO:0043412,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_1152682_0	1267535.KB906767_gene2433	6.353e-301	944.0	COG0550@1|root,COG0550@2|Bacteria,3Y343@57723|Acidobacteria,2JHPW@204432|Acidobacteriia	204432|Acidobacteriia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD1_k127_1152682_14	204669.Acid345_3341	1.056e-91	314.0	COG0322@1|root,COG0758@1|root,COG0322@2|Bacteria,COG0758@2|Bacteria,3Y42M@57723|Acidobacteria,2JI6N@204432|Acidobacteriia	204432|Acidobacteriia	LU	DNA protecting protein DprA	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_1152682_38	1123073.KB899244_gene186	3.723e-26	124.0	COG1470@1|root,COG3209@1|root,COG5184@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG5184@2|Bacteria,1N55D@1224|Proteobacteria,1T481@1236|Gammaproteobacteria,1XD8U@135614|Xanthomonadales	135614|Xanthomonadales	DMZ	IPT/TIG domain	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HKD1_k127_1152682_3	1254432.SCE1572_07650	1.1e-221	700.0	COG1024@1|root,COG1024@2|Bacteria,1N817@1224|Proteobacteria,4388N@68525|delta/epsilon subdivisions,2XA2D@28221|Deltaproteobacteria,2YW7N@29|Myxococcales	28221|Deltaproteobacteria	I	Enoyl-CoA hydratase/isomerase	-	-	4.1.2.44	ko:K15513	ko00362,map00362	-	R09556	RC03426	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD1_k127_1152682_4	391625.PPSIR1_20834	4.01e-212	668.0	COG3396@1|root,COG3396@2|Bacteria,1MXUK@1224|Proteobacteria,437U1@68525|delta/epsilon subdivisions,2X33K@28221|Deltaproteobacteria,2YU2K@29|Myxococcales	28221|Deltaproteobacteria	S	benzoyl-CoA oxygenase	-	-	1.14.13.208	ko:K15512	ko00362,map00362	-	R09555	RC01739	ko00000,ko00001,ko01000	-	-	-	-
HKD1_k127_1152682_36	1379698.RBG1_1C00001G0893	5.282e-35	143.0	COG1309@1|root,COG1309@2|Bacteria,2NS0M@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	ko:K09017	-	-	-	-	ko00000,ko03000	-	-	-	TetR_C_4,TetR_N
HKD1_k127_1152682_9	1379698.RBG1_1C00001G0806	1.331e-112	370.0	COG1024@1|root,COG1024@2|Bacteria,2NPAC@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD1_k127_1152682_23	1120985.AUMI01000021_gene2825	3.454e-63	226.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4H931@909932|Negativicutes	909932|Negativicutes	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_1152682_21	1122221.JHVI01000003_gene383	1.358e-66	236.0	COG1028@1|root,COG1028@2|Bacteria,1WIJY@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	IQ	COGs COG1028 Dehydrogenase with different specificities (related to short-chain alcohol dehydrogenase)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_5	580327.Tthe_1248	1.029e-188	607.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,42EM9@68295|Thermoanaerobacterales	186801|Clostridia	J	L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_1152682_41	867903.ThesuDRAFT_00144	2.179e-22	102.0	COG1310@1|root,COG1310@2|Bacteria,1V6TY@1239|Firmicutes,24JI8@186801|Clostridia	186801|Clostridia	S	Mov34 MPN PAD-1 family	-	-	3.13.1.6	ko:K21140	ko04122,map04122	-	R11524	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	Prok-JAB
HKD1_k127_1152682_29	1267533.KB906735_gene5073	1.729e-55	213.0	COG4783@1|root,COG4783@2|Bacteria,3Y6B5@57723|Acidobacteria,2JK7Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD1_k127_1152682_44	1267533.KB906733_gene3063	1.108e-15	79.0	COG0268@1|root,COG0268@2|Bacteria,3Y5CZ@57723|Acidobacteria,2JJS9@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD1_k127_1152682_40	1173024.KI912150_gene1205	5.708e-25	109.0	2CKCH@1|root,331PP@2|Bacteria,1G6N7@1117|Cyanobacteria,1JJ4W@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_34	1403313.AXBR01000008_gene621	9.122e-39	158.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,4HBB4@91061|Bacilli,1ZBST@1386|Bacillus	91061|Bacilli	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD1_k127_1152682_43	1267534.KB906754_gene2838	2.585e-16	86.0	COG2980@1|root,COG2980@2|Bacteria,3Y4V4@57723|Acidobacteria,2JJKB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lipopolysaccharide-assembly	-	-	-	-	-	-	-	-	-	-	-	-	LptE
HKD1_k127_1152682_33	1122915.AUGY01000084_gene6195	3.914e-42	158.0	COG0346@1|root,COG0346@2|Bacteria,1VCGT@1239|Firmicutes,4HKDV@91061|Bacilli,26ZEW@186822|Paenibacillaceae	91061|Bacilli	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_1152682_42	1047013.AQSP01000138_gene1046	6.717e-20	104.0	COG3307@1|root,COG3307@2|Bacteria,2NQ25@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K18814	-	-	-	-	ko00000,ko02000	9.B.67.1	-	-	Wzy_C
HKD1_k127_1152682_27	234267.Acid_3348	8.665e-58	217.0	COG0624@1|root,COG0624@2|Bacteria,3Y2XS@57723|Acidobacteria	57723|Acidobacteria	E	PFAM Peptidase M20	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_1152682_7	1410619.SRDD_26560	3.35e-118	402.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,1RMIT@1236|Gammaproteobacteria,400MR@613|Serratia	1236|Gammaproteobacteria	E	Gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_1152682_31	1379698.RBG1_1C00001G0328	2.889e-51	186.0	2C7E0@1|root,330TX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_13	309801.trd_A0816	7.905e-93	325.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,2G66B@200795|Chloroflexi,27XNK@189775|Thermomicrobia	189775|Thermomicrobia	M	PFAM sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD1_k127_1152682_18	1117319.PSPO_05611	2.209e-71	255.0	COG1817@1|root,COG1817@2|Bacteria,1N644@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
HKD1_k127_1152682_17	1462527.CCDM010000006_gene4704	2.4e-77	269.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,4HCBR@91061|Bacilli,23MKV@182709|Oceanobacillus	91061|Bacilli	Q	Fumarylacetoacetate (FAA) hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_1152682_10	518766.Rmar_0181	1.983e-111	371.0	COG0492@1|root,COG0492@2|Bacteria,4NEVX@976|Bacteroidetes,1FIUF@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_1152682_16	504728.K649_01740	1.073e-79	277.0	COG1250@1|root,COG1250@2|Bacteria,1WIN8@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	PFAM 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_1152682_15	797209.ZOD2009_04172	3.39e-80	275.0	COG1024@1|root,arCOG00239@2157|Archaea,2XTF0@28890|Euryarchaeota,23SMM@183963|Halobacteria	183963|Halobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	ech4	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD1_k127_1152682_11	1382306.JNIM01000001_gene3772	2.14e-105	352.0	COG0604@1|root,COG0604@2|Bacteria,2G7Z0@200795|Chloroflexi	200795|Chloroflexi	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1152682_1	671143.DAMO_2651	8.695e-265	831.0	COG0021@1|root,COG0021@2|Bacteria,2NS3T@2323|unclassified Bacteria	2|Bacteria	G	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_1152682_25	204669.Acid345_2517	7.928e-63	223.0	COG3809@1|root,COG3809@2|Bacteria,3Y803@57723|Acidobacteria	57723|Acidobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	DZR,zf-TFIIB
HKD1_k127_1152682_32	1210884.HG799464_gene10684	3.134e-44	167.0	COG4762@1|root,COG4762@2|Bacteria,2IZUS@203682|Planctomycetes	203682|Planctomycetes	S	Domain of unknown function (DUF1990)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1990
HKD1_k127_1152682_48	491916.RHECIAT_PC0000155	2.608e-07	64.0	2AK0N@1|root,31AQ5@2|Bacteria,1Q5Y9@1224|Proteobacteria,2VC84@28211|Alphaproteobacteria,4BIAM@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_46	1131266.ARWQ01000002_gene698	2.835e-08	66.0	2DZ6M@1|root,2N589@2157|Archaea,41T6W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_22	234267.Acid_3083	5.812e-66	235.0	COG3595@1|root,COG3595@2|Bacteria,3Y5AF@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_6	497964.CfE428DRAFT_2365	2.662e-141	454.0	COG1090@1|root,COG1090@2|Bacteria	2|Bacteria	S	coenzyme binding	yfcH	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase
HKD1_k127_1152682_37	886377.Murru_3175	1.828e-32	130.0	COG3011@1|root,COG3011@2|Bacteria,4NQ93@976|Bacteroidetes,1I30U@117743|Flavobacteriia	976|Bacteroidetes	S	Thiol-disulfide oxidoreductase	yuxK	-	-	-	-	-	-	-	-	-	-	-	DUF393
HKD1_k127_1152682_12	1120960.ATXG01000017_gene1388	7.174e-99	332.0	COG0702@1|root,COG0702@2|Bacteria,2IQ0Z@201174|Actinobacteria,4FM9R@85023|Microbacteriaceae	201174|Actinobacteria	GM	NmrA-like family	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	Methyltransf_21,NAD_binding_10
HKD1_k127_1152682_20	1394178.AWOO02000007_gene3118	3.614e-67	235.0	COG1309@1|root,COG1309@2|Bacteria,2GJES@201174|Actinobacteria,4EIGA@85012|Streptosporangiales	201174|Actinobacteria	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_1152682_39	497964.CfE428DRAFT_2364	4.05e-26	112.0	COG3011@1|root,COG3011@2|Bacteria	2|Bacteria	CH	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF393
HKD1_k127_1152682_30	497964.CfE428DRAFT_2363	1.187e-52	188.0	2DN6W@1|root,32UIF@2|Bacteria,46WNT@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1152682_8	1382306.JNIM01000001_gene3484	1.641e-115	391.0	COG0365@1|root,COG0365@2|Bacteria	2|Bacteria	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	badA	-	6.2.1.25,6.2.1.27	ko:K04105,ko:K04110	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R01300,R01422	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_1165975_10	1329516.JPST01000006_gene1591	5.887e-144	492.0	COG0247@1|root,COG0277@1|root,COG0247@2|Bacteria,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,4H9UU@91061|Bacilli,27CQN@186824|Thermoactinomycetaceae	91061|Bacilli	C	FAD linked oxidases, C-terminal domain	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1165975_7	1446473.JHWH01000017_gene3971	1.459e-172	560.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2PUGP@265|Paracoccus	28211|Alphaproteobacteria	E	Gamma-glutamyltranspeptidase	ggt	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_1165975_28	555779.Dthio_PD1759	8.111e-08	53.0	COG1724@1|root,COG1724@2|Bacteria,1NA6Q@1224|Proteobacteria	1224|Proteobacteria	N	PFAM YcfA family protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_1165975_24	671143.DAMO_0594	2.445e-31	124.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_1165975_15	1379270.AUXF01000004_gene3287	5.391e-111	374.0	COG0247@1|root,COG0247@2|Bacteria,1ZSTK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	4Fe-4S binding domain	-	-	-	ko:K11473	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001	-	-	-	CCG
HKD1_k127_1165975_17	593117.TGAM_0391	5.69e-74	265.0	COG1820@1|root,arCOG00699@2157|Archaea,2Y3HD@28890|Euryarchaeota	28890|Euryarchaeota	G	Amidohydrolase family	-	-	3.5.1.25	ko:K01443	ko00520,ko01130,map00520,map01130	-	R02059	RC00166,RC00300	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1165975_21	416591.Tlet_1672	1.336e-40	168.0	COG1649@1|root,COG1649@2|Bacteria,2GCSB@200918|Thermotogae	200918|Thermotogae	S	Glycosyl hydrolase-like 10	-	-	-	-	-	-	-	-	-	-	-	-	GHL10
HKD1_k127_1165975_4	204669.Acid345_2136	1.289e-239	783.0	COG1629@1|root,COG1629@2|Bacteria,3Y2K8@57723|Acidobacteria,2JKEC@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB-dependent Receptor Plug	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_1165975_0	234267.Acid_1376	0.0	1405.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_1165975_1	234267.Acid_2405	0.0	1305.0	COG4932@1|root,COG4932@2|Bacteria,3Y73S@57723|Acidobacteria	2|Bacteria	M	PFAM Cna B domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarbopepD_reg_2,CarboxypepD_reg,OMP_b-brl_3,OmpA,Plug,RHS_repeat
HKD1_k127_1165975_3	344747.PM8797T_07137	6.671e-252	805.0	COG1680@1|root,COG3876@1|root,COG1680@2|Bacteria,COG3876@2|Bacteria,2IXF2@203682|Planctomycetes	203682|Planctomycetes	V	beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343
HKD1_k127_1165975_12	518766.Rmar_0925	2.149e-135	452.0	COG1472@1|root,COG1680@1|root,COG1472@2|Bacteria,COG1680@2|Bacteria,4NET8@976|Bacteroidetes,1FJ9E@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_1165975_11	1340493.JNIF01000003_gene3872	8.763e-141	463.0	COG0591@1|root,COG0591@2|Bacteria	2|Bacteria	E	symporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF1343,SSF
HKD1_k127_1165975_16	1267535.KB906767_gene2107	1.109e-89	304.0	COG2103@1|root,COG2103@2|Bacteria,3Y378@57723|Acidobacteria,2JHNG@204432|Acidobacteriia	204432|Acidobacteriia	S	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate	-	-	4.2.1.126	ko:K07106	ko00520,ko01100,map00520,map01100	-	R08555	RC00397,RC00746	ko00000,ko00001,ko01000	-	-	-	SIS_2
HKD1_k127_1165975_20	292459.STH292	1.1e-40	164.0	COG2971@1|root,COG2971@2|Bacteria,1V0VG@1239|Firmicutes,24BFK@186801|Clostridia	186801|Clostridia	G	BadF BadG BcrA BcrD	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005975,GO:0006040,GO:0006044,GO:0006082,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0017076,GO:0019200,GO:0019752,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0045127,GO:0046835,GO:0071704,GO:0097159,GO:0097172,GO:0097367,GO:1901071,GO:1901135,GO:1901265,GO:1901363	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD1_k127_1165975_22	2340.JV46_22820	1.233e-37	153.0	COG0583@1|root,COG0583@2|Bacteria,1MWVU@1224|Proteobacteria,1RQJD@1236|Gammaproteobacteria,1J60A@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	K	LysR substrate binding domain	rbcR	-	-	ko:K21703,ko:K21711	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_1165975_19	335543.Sfum_0911	3.255e-54	205.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,42PZJ@68525|delta/epsilon subdivisions,2WMGB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase, class V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_1165975_2	717772.THIAE_08340	1.204e-262	824.0	COG0296@1|root,COG0296@2|Bacteria,1MVM7@1224|Proteobacteria,1SYH1@1236|Gammaproteobacteria,45ZV2@72273|Thiotrichales	72273|Thiotrichales	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_1165975_8	1267535.KB906767_gene3334	8.981e-159	516.0	COG1449@1|root,COG1449@2|Bacteria,3Y2JJ@57723|Acidobacteria,2JHW6@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glycosyl hydrolase 57 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF3536,Glyco_hydro_57
HKD1_k127_1165975_14	204669.Acid345_0905	2.544e-115	385.0	COG4214@1|root,COG4214@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	ko:K10544	ko02010,map02010	M00215	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.4	-	-	BPD_transp_2
HKD1_k127_1165975_6	580331.Thit_0247	1.502e-180	579.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,42ESS@68295|Thermoanaerobacterales	186801|Clostridia	P	Part of the ABC transporter complex XylFGH involved in xylose import. Responsible for energy coupling to the transport system	xylG	-	3.6.3.17	ko:K10441,ko:K10545	ko02010,map02010	M00212,M00215	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.4	-	-	ABC_tran
HKD1_k127_1165975_27	1210884.HG799465_gene12035	2.141e-08	57.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	23S_rRNA_IVP
HKD1_k127_1165975_25	525903.Taci_1495	5.054e-21	97.0	COG0399@1|root,COG0399@2|Bacteria	2|Bacteria	E	UDP-4-amino-4-deoxy-L-arabinose aminotransferase	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	23S_rRNA_IVP
HKD1_k127_1165975_13	198467.NP92_12210	1.542e-122	402.0	COG4213@1|root,COG4213@2|Bacteria,1TR3Q@1239|Firmicutes,4HCK3@91061|Bacilli,21UZ3@150247|Anoxybacillus	91061|Bacilli	G	Periplasmic binding protein domain	-	-	-	ko:K02058,ko:K10543	ko02010,map02010	M00215,M00221	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2,3.A.1.2.4	-	-	Peripla_BP_4
HKD1_k127_1165975_18	1123371.ATXH01000045_gene1871	7.158e-63	226.0	28I4Y@1|root,2Z88D@2|Bacteria,2GI90@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1165975_9	204669.Acid345_0995	3.145e-153	496.0	COG3191@1|root,COG3191@2|Bacteria,3Y699@57723|Acidobacteria	57723|Acidobacteria	M	Peptidase family S58	-	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD1_k127_1165975_29	1237500.ANBA01000006_gene2497	9.537e-07	55.0	COG1167@1|root,COG1167@2|Bacteria,2GJ5P@201174|Actinobacteria,4EGIU@85012|Streptosporangiales	201174|Actinobacteria	K	Aminotransferase class I and II	pdxR	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD1_k127_1165975_23	102125.Xen7305DRAFT_00050810	4.753e-32	132.0	COG0454@1|root,COG0456@2|Bacteria,1GIEU@1117|Cyanobacteria,3VKQD@52604|Pleurocapsales	1117|Cyanobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_1165975_5	1340493.JNIF01000004_gene448	9.434e-212	677.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3IB@57723|Acidobacteria	57723|Acidobacteria	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_1165975_26	207954.MED92_05418	1.659e-09	64.0	2CDP6@1|root,32RY5@2|Bacteria,1N1TI@1224|Proteobacteria,1SC2T@1236|Gammaproteobacteria,1XKWR@135619|Oceanospirillales	135619|Oceanospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1195810_1	1267535.KB906767_gene1129	9.408e-87	298.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_1195810_2	234267.Acid_7677	6.818e-62	218.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_1195810_0	1382359.JIAL01000001_gene3009	5.19e-92	313.0	COG1044@1|root,COG1044@2|Bacteria,3Y2JC@57723|Acidobacteria,2JI2Y@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxD	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HKD1_k127_1202392_4	497964.CfE428DRAFT_0944	1.277e-28	129.0	COG4258@1|root,COG4258@2|Bacteria,46TC6@74201|Verrucomicrobia	2|Bacteria	S	MMPL family	hpnN	-	-	ko:K07003	-	-	-	-	ko00000	-	-	-	MMPL
HKD1_k127_1202392_2	497964.CfE428DRAFT_4794	3.05e-86	289.0	COG3794@1|root,COG3794@2|Bacteria,46SUG@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_1202392_0	452637.Oter_1616	6.736e-170	551.0	COG0642@1|root,COG2205@2|Bacteria,46TFN@74201|Verrucomicrobia	74201|Verrucomicrobia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_1202392_1	497964.CfE428DRAFT_4796	1.461e-150	486.0	28IVM@1|root,2Z8U0@2|Bacteria,46S57@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1202392_3	1403819.BATR01000112_gene3842	2.131e-56	205.0	COG0745@1|root,COG0745@2|Bacteria	1403819.BATR01000112_gene3842|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1238966_3	760117.JN27_20490	3.378e-169	537.0	COG4952@1|root,COG4952@2|Bacteria,1PSSV@1224|Proteobacteria,2VNT0@28216|Betaproteobacteria,472DW@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Xylose isomerase-like TIM barrel	-	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_1238966_6	717605.Theco_1264	7.246e-122	411.0	COG1070@1|root,COG1070@2|Bacteria,1TP7Z@1239|Firmicutes,4HB5X@91061|Bacilli,26RVA@186822|Paenibacillaceae	91061|Bacilli	G	Involved in the catabolism of L-rhamnose (6-deoxy-L- mannose). Catalyzes the transfer of the gamma-phosphate group from ATP to the 1-hydroxyl group of L-rhamnulose to yield L-rhamnulose 1-phosphate	yulC	-	2.7.1.5	ko:K00848	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01902,R03014	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_1238966_5	357808.RoseRS_4459	5.234e-142	467.0	COG1139@1|root,COG1139@2|Bacteria,2G665@200795|Chloroflexi,37659@32061|Chloroflexia	32061|Chloroflexia	C	TIGRFAM iron-sulfur cluster binding protein	-	-	-	ko:K18929	-	-	-	-	ko00000	-	-	-	DUF3390,Fer4_7,Fer4_8,LUD_dom
HKD1_k127_1238966_10	880073.Calab_0492	0.000729	44.0	COG1943@1|root,COG1943@2|Bacteria,2NR5M@2323|unclassified Bacteria	2|Bacteria	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_1238966_9	1173028.ANKO01000220_gene584	1.379e-24	112.0	COG1556@1|root,COG1556@2|Bacteria	2|Bacteria	S	LUD domain	lldG	-	-	ko:K00782	-	-	-	-	ko00000	-	-	-	LUD_dom
HKD1_k127_1238966_2	886293.Sinac_6993	3.259e-196	627.0	COG1129@1|root,COG1129@2|Bacteria,2IWTU@203682|Planctomycetes	203682|Planctomycetes	P	Part of the ABC transporter complex RbsABC involved in ribose import. Responsible for energy coupling to the transport system	-	-	3.6.3.17	ko:K10562	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.9	-	-	ABC_tran
HKD1_k127_1238966_7	886293.Sinac_6994	5.821e-97	327.0	COG1172@1|root,COG1172@2|Bacteria,2J3I0@203682|Planctomycetes	203682|Planctomycetes	G	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10560	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2
HKD1_k127_1238966_1	234267.Acid_7826	7.909e-269	844.0	COG1172@1|root,COG1879@1|root,COG1172@2|Bacteria,COG1879@2|Bacteria,3Y5DG@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10559,ko:K10561	ko02010,map02010	M00220	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.9	-	-	BPD_transp_2,Peripla_BP_4
HKD1_k127_1238966_8	935948.KE386494_gene857	1.085e-34	139.0	COG3254@1|root,COG3254@2|Bacteria,1VA1C@1239|Firmicutes,24JG9@186801|Clostridia	186801|Clostridia	G	Involved in the anomeric conversion of L-rhamnose	-	-	5.1.3.32	ko:K03534	-	-	R10819	RC00563	ko00000,ko01000	-	-	-	rhaM
HKD1_k127_1238966_4	234267.Acid_4055	1.936e-149	485.0	COG0823@1|root,COG0823@2|Bacteria,3Y2NB@57723|Acidobacteria	57723|Acidobacteria	U	Oligogalacturonate lyase	-	-	4.2.2.6	ko:K01730	ko00040,map00040	-	R04382	RC02124,RC02427	ko00000,ko00001,ko01000	-	-	-	Pectate_lyase22
HKD1_k127_1238966_0	234267.Acid_7415	1.424e-293	940.0	COG3188@1|root,COG3188@2|Bacteria,3Y42P@57723|Acidobacteria	57723|Acidobacteria	NU	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_1252583_25	251221.35211166	5.042e-62	228.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD1_k127_1252583_62	1122175.ATXU01000012_gene1695	4.305e-10	68.0	COG2197@1|root,COG2197@2|Bacteria,2GJRY@201174|Actinobacteria,4FQUJ@85023|Microbacteriaceae	201174|Actinobacteria	KT	helix_turn_helix, Lux Regulon	hrrA2	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_1252583_1	1131269.AQVV01000005_gene331	3.77e-209	659.0	COG0174@1|root,COG0174@2|Bacteria	2|Bacteria	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_1252583_0	521674.Plim_3789	3.418e-240	758.0	COG1166@1|root,COG1166@2|Bacteria,2IX6P@203682|Planctomycetes	203682|Planctomycetes	H	Catalyzes the biosynthesis of agmatine from arginine	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N
HKD1_k127_1252583_16	1379698.RBG1_1C00001G0709	2.519e-78	275.0	COG1899@1|root,COG1899@2|Bacteria,2NR8I@2323|unclassified Bacteria	2|Bacteria	O	Deoxyhypusine synthase	-	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006807,GO:0008150,GO:0008152,GO:0008612,GO:0009058,GO:0009987,GO:0010467,GO:0016740,GO:0016765,GO:0018193,GO:0018205,GO:0019538,GO:0034038,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051604,GO:0071704,GO:1901564	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD1_k127_1252583_21	253839.SSNG_05958	6.774e-67	244.0	2EY5M@1|root,33REA@2|Bacteria,2I8SA@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1252583_5	1121935.AQXX01000069_gene5900	5.746e-165	537.0	COG2303@1|root,COG2303@2|Bacteria,1NV3A@1224|Proteobacteria,1RNQ5@1236|Gammaproteobacteria,1XK0D@135619|Oceanospirillales	135619|Oceanospirillales	E	COG2303 Choline dehydrogenase and related flavoproteins	-	-	1.1.3.6	ko:K03333	ko00984,ko01120,map00984,map01120	-	R01459	RC00146	ko00000,ko00001,ko01000	-	-	-	GMC_oxred_C,GMC_oxred_N,NAD_binding_8
HKD1_k127_1252583_2	1122164.JHWF01000024_gene2565	8.813e-199	642.0	COG1409@1|root,COG1409@2|Bacteria,1R4EJ@1224|Proteobacteria,1T7TW@1236|Gammaproteobacteria,1JFUH@118969|Legionellales	118969|Legionellales	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_1252583_17	1250232.JQNJ01000001_gene3833	6.369e-73	256.0	COG0010@1|root,COG0010@2|Bacteria,4NE01@976|Bacteroidetes,1HYIB@117743|Flavobacteriia	976|Bacteroidetes	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_1252583_49	401053.AciPR4_1510	2.814e-29	132.0	COG0457@1|root,COG0457@2|Bacteria,3Y3JH@57723|Acidobacteria,2JI8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_1252583_6	661478.OP10G_2607	2.073e-155	499.0	COG0498@1|root,COG0498@2|Bacteria	2|Bacteria	E	threonine synthase activity	MA20_41710	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_1252583_31	321332.CYB_1473	3.626e-52	189.0	COG0652@1|root,COG0652@2|Bacteria,1G5BD@1117|Cyanobacteria,1H0AB@1129|Synechococcus	1117|Cyanobacteria	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	rot	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_1252583_34	1243664.CAVL020000049_gene5093	2.818e-50	189.0	COG0351@1|root,COG0351@2|Bacteria,1TQ4A@1239|Firmicutes,4HAAH@91061|Bacilli,1ZCQT@1386|Bacillus	91061|Bacilli	H	Phosphomethylpyrimidine kinase	thiD	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K00941,ko:K14153	ko00730,ko01100,map00730,map01100	M00127	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_1252583_63	714943.Mucpa_7131	4.202e-09	59.0	COG3695@1|root,COG3695@2|Bacteria,4NZHS@976|Bacteroidetes,1IZ68@117747|Sphingobacteriia	976|Bacteroidetes	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_binding_1
HKD1_k127_1252583_47	243231.GSU0587	3.068e-31	131.0	COG0352@1|root,COG0352@2|Bacteria,1RDSU@1224|Proteobacteria,42NTP@68525|delta/epsilon subdivisions,2WQME@28221|Deltaproteobacteria,43UPN@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	tenI	GO:0003674,GO:0003824,GO:0004789,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD1_k127_1252583_64	682795.AciX8_0471	5.748e-09	63.0	2DTVW@1|root,33MW2@2|Bacteria,3Y606@57723|Acidobacteria,2JP2X@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1252583_28	204669.Acid345_4380	8.023e-58	226.0	COG0457@1|root,COG2956@1|root,COG0457@2|Bacteria,COG2956@2|Bacteria,3Y89N@57723|Acidobacteria	57723|Acidobacteria	G	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HKD1_k127_1252583_27	216591.BCAL3131	1.245e-59	216.0	COG1682@1|root,COG1682@2|Bacteria,1N0X3@1224|Proteobacteria,2VHT7@28216|Betaproteobacteria,1K0NU@119060|Burkholderiaceae	28216|Betaproteobacteria	GM	Transport permease protein	tagG	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HKD1_k127_1252583_23	157783.LK03_10480	8.612e-64	234.0	COG0079@1|root,COG0079@2|Bacteria,1MW7I@1224|Proteobacteria,1RZAD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	aminotransferase	hisC2	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1252583_4	886293.Sinac_1825	2.84e-178	568.0	COG2256@1|root,COG2256@2|Bacteria,2IX8G@203682|Planctomycetes	203682|Planctomycetes	L	ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_1252583_68	1254432.SCE1572_50430	0.0008567	50.0	COG0500@1|root,COG2226@2|Bacteria,1Q8Y8@1224|Proteobacteria,439U4@68525|delta/epsilon subdivisions,2X57M@28221|Deltaproteobacteria,2Z089@29|Myxococcales	28221|Deltaproteobacteria	Q	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_31
HKD1_k127_1252583_66	598659.NAMH_1112	1.43e-05	51.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,42VNG@68525|delta/epsilon subdivisions,2YQ9F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_1252583_19	204669.Acid345_4201	4.539e-69	238.0	COG1403@1|root,COG1403@2|Bacteria,3Y3PW@57723|Acidobacteria,2JI65@204432|Acidobacteriia	204432|Acidobacteriia	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD1_k127_1252583_8	1184267.A11Q_487	6.354e-148	473.0	COG0596@1|root,COG0596@2|Bacteria,1MWW8@1224|Proteobacteria,42P6R@68525|delta/epsilon subdivisions,2MSMN@213481|Bdellovibrionales,2WKXS@28221|Deltaproteobacteria	213481|Bdellovibrionales	E	Belongs to the peptidase S33 family	pip	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD1_k127_1252583_44	439235.Dalk_1937	5.51e-34	140.0	COG1040@1|root,COG1040@2|Bacteria,1RHAV@1224|Proteobacteria,42SV9@68525|delta/epsilon subdivisions,2WPXX@28221|Deltaproteobacteria,2MJUD@213118|Desulfobacterales	28221|Deltaproteobacteria	S	PFAM Phosphoribosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Pribosyltran
HKD1_k127_1252583_57	204669.Acid345_4135	8.015e-24	106.0	COG1734@1|root,COG1734@2|Bacteria,3Y5PJ@57723|Acidobacteria,2JK2N@204432|Acidobacteriia	204432|Acidobacteriia	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_1252583_51	887929.HMP0721_0990	1.964e-28	119.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,25WC9@186806|Eubacteriaceae	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD1_k127_1252583_14	204669.Acid345_0023	4.967e-83	287.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	57723|Acidobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_1252583_48	204669.Acid345_0022	1.716e-29	123.0	COG0799@1|root,COG0799@2|Bacteria,3Y5SD@57723|Acidobacteria,2JJ9Z@204432|Acidobacteriia	204432|Acidobacteriia	S	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD1_k127_1252583_41	671143.DAMO_0333	1.627e-37	149.0	COG1057@1|root,COG1057@2|Bacteria,2NPJU@2323|unclassified Bacteria	2|Bacteria	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	GO:0000309,GO:0003674,GO:0003824,GO:0004515,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0040007,GO:0043436,GO:0043648,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0046483,GO:0046496,GO:0051186,GO:0051188,GO:0055086,GO:0070566,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.7.18,3.6.1.55	ko:K00969,ko:K03574	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	CTP_transf_like
HKD1_k127_1252583_10	1267535.KB906767_gene4592	7.588e-130	423.0	COG0536@1|root,COG0536@2|Bacteria,3Y2J7@57723|Acidobacteria,2JI5G@204432|Acidobacteriia	204432|Acidobacteriia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD1_k127_1252583_43	28072.Nos7524_5355	3.296e-34	133.0	COG0211@1|root,COG0211@2|Bacteria,1G7RW@1117|Cyanobacteria,1HNYF@1161|Nostocales	1117|Cyanobacteria	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD1_k127_1252583_53	583345.Mmol_0521	3.249e-27	113.0	COG0261@1|root,COG0261@2|Bacteria,1MZEW@1224|Proteobacteria,2VSHZ@28216|Betaproteobacteria,2KMZW@206350|Nitrosomonadales	206350|Nitrosomonadales	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD1_k127_1252583_3	1144275.COCOR_06267	2.505e-184	587.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria,2YUJ1@29|Myxococcales	28221|Deltaproteobacteria	I	Biotin carboxylase	accC	-	6.3.4.14,6.4.1.1,6.4.1.2	ko:K01959,ko:K01961	ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko01230,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212,map01230	M00082,M00173,M00376,M00620	R00344,R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_1252583_42	1111479.AXAR01000003_gene1669	5.463e-35	143.0	COG0511@1|root,COG0511@2|Bacteria,1VAB7@1239|Firmicutes,4HKCS@91061|Bacilli,279UX@186823|Alicyclobacillaceae	91061|Bacilli	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD1_k127_1252583_54	639283.Snov_1473	2.015e-26	115.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,3EZJI@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	structural constituent of ribosome	rplQ	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD1_k127_1252583_9	1267533.KB906735_gene5103	7.571e-145	466.0	COG0202@1|root,COG0202@2|Bacteria,3Y3HK@57723|Acidobacteria,2JHZ6@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD1_k127_1252583_18	717231.Flexsi_0490	7.389e-72	248.0	COG0522@1|root,COG0522@2|Bacteria,2GF55@200930|Deferribacteres	200930|Deferribacteres	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD1_k127_1252583_38	1267535.KB906767_gene2680	2.632e-46	170.0	COG0100@1|root,COG0100@2|Bacteria,3Y4BS@57723|Acidobacteria,2JJ4Q@204432|Acidobacteriia	204432|Acidobacteriia	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD1_k127_1252583_33	234267.Acid_5093	4.369e-51	184.0	COG0099@1|root,COG0099@2|Bacteria,3Y4KC@57723|Acidobacteria	57723|Acidobacteria	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_1252583_60	234267.Acid_5094	1.558e-14	74.0	COG0257@1|root,COG0257@2|Bacteria,3Y5X6@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD1_k127_1252583_46	401053.AciPR4_3213	2.356e-32	127.0	COG0361@1|root,COG0361@2|Bacteria,3Y55Z@57723|Acidobacteria,2JJUQ@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_1252583_12	871963.Desdi_0457	5.769e-94	316.0	COG0024@1|root,COG0024@2|Bacteria,1TQC1@1239|Firmicutes,248I8@186801|Clostridia,260SK@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM methionine aminopeptidase, type I	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_1252583_32	747365.Thena_1602	3.09e-51	189.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,42ES7@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
HKD1_k127_1252583_7	234267.Acid_5098	2.621e-153	499.0	COG0201@1|root,COG0201@2|Bacteria,3Y38D@57723|Acidobacteria	57723|Acidobacteria	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD1_k127_1252583_39	1047013.AQSP01000074_gene1895	2.597e-44	165.0	COG0200@1|root,COG0200@2|Bacteria,2NPNV@2323|unclassified Bacteria	2|Bacteria	J	Binds to the 23S rRNA	rplO	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0005886,GO:0015934,GO:0016020,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071944,GO:1990904	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD1_k127_1252583_61	639030.JHVA01000001_gene1536	3.936e-14	75.0	COG1841@1|root,COG1841@2|Bacteria,3Y5I2@57723|Acidobacteria,2JJZB@204432|Acidobacteriia	204432|Acidobacteriia	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD1_k127_1252583_24	720554.Clocl_3878	1.14e-63	222.0	COG0098@1|root,COG0098@2|Bacteria,1V1B1@1239|Firmicutes,24G5D@186801|Clostridia,3WICZ@541000|Ruminococcaceae	186801|Clostridia	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD1_k127_1252583_40	1340493.JNIF01000003_gene3223	1.413e-40	154.0	COG0256@1|root,COG0256@2|Bacteria,3Y5CH@57723|Acidobacteria	57723|Acidobacteria	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD1_k127_1252583_29	1267533.KB906735_gene5115	5.957e-55	198.0	COG0097@1|root,COG0097@2|Bacteria,3Y496@57723|Acidobacteria,2JJ4H@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD1_k127_1252583_37	1340493.JNIF01000003_gene3221	8.115e-48	174.0	COG0096@1|root,COG0096@2|Bacteria,3Y4IE@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD1_k127_1252583_56	1205910.B005_2718	3.333e-24	102.0	COG0199@1|root,COG0199@2|Bacteria,2IQ8R@201174|Actinobacteria,4EKES@85012|Streptosporangiales	201174|Actinobacteria	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD1_k127_1252583_15	1267533.KB906735_gene5118	1.72e-82	277.0	COG0094@1|root,COG0094@2|Bacteria,3Y3PS@57723|Acidobacteria,2JHV4@204432|Acidobacteriia	204432|Acidobacteriia	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD1_k127_1252583_52	1168059.KB899087_gene1495	3.248e-28	117.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,3EZQP@335928|Xanthobacteraceae	28211|Alphaproteobacteria	J	One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplX	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD1_k127_1252583_35	1382359.JIAL01000001_gene1706	1.763e-49	179.0	COG0093@1|root,COG0093@2|Bacteria,3Y4N0@57723|Acidobacteria,2JJ86@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD1_k127_1252583_58	643648.Slip_2228	3.969e-21	98.0	COG0186@1|root,COG0186@2|Bacteria,1V9YC@1239|Firmicutes,24MSW@186801|Clostridia,42K48@68298|Syntrophomonadaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD1_k127_1252583_67	639282.DEFDS_1764	0.0005067	45.0	COG0255@1|root,COG0255@2|Bacteria,2GG0S@200930|Deferribacteres	200930|Deferribacteres	J	Ribosomal L29 protein	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD1_k127_1252583_22	867903.ThesuDRAFT_00566	2.626e-64	222.0	COG0197@1|root,COG0197@2|Bacteria,1V1AY@1239|Firmicutes,24FQX@186801|Clostridia,3WCGY@538999|Clostridiales incertae sedis	186801|Clostridia	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD1_k127_1252583_13	204669.Acid345_1232	1.989e-92	309.0	COG0092@1|root,COG0092@2|Bacteria,3Y3ZN@57723|Acidobacteria,2JIRU@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD1_k127_1252583_55	1121428.DESHY_150047___1	2.556e-24	110.0	COG0091@1|root,COG0091@2|Bacteria,1V6PU@1239|Firmicutes,24JF4@186801|Clostridia,2621D@186807|Peptococcaceae	186801|Clostridia	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD1_k127_1252583_45	363253.LI0964	9.118e-34	132.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,42THY@68525|delta/epsilon subdivisions,2WQ0F@28221|Deltaproteobacteria,2MBZW@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006996,GO:0008150,GO:0009987,GO:0015935,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0042254,GO:0042255,GO:0042274,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043933,GO:0044085,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071826,GO:0071840,GO:1990904	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD1_k127_1252583_11	1267535.KB906767_gene2701	1.059e-121	395.0	COG0090@1|root,COG0090@2|Bacteria,3Y3DH@57723|Acidobacteria,2JI2K@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_1252583_59	204669.Acid345_1228	6.243e-21	95.0	COG0089@1|root,COG0089@2|Bacteria,3Y58W@57723|Acidobacteria,2JJR2@204432|Acidobacteriia	204432|Acidobacteriia	J	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome	rplW	-	-	ko:K02892	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L23
HKD1_k127_1252583_26	546271.Selsp_1489	4.801e-60	215.0	COG0088@1|root,COG0088@2|Bacteria,1TPGW@1239|Firmicutes,4H24E@909932|Negativicutes	909932|Negativicutes	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD1_k127_1252583_20	234267.Acid_5118	2.571e-68	239.0	COG0087@1|root,COG0087@2|Bacteria,3Y2H7@57723|Acidobacteria	57723|Acidobacteria	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD1_k127_1252583_30	1267535.KB906767_gene2705	6.949e-53	188.0	COG0051@1|root,COG0051@2|Bacteria,3Y4V5@57723|Acidobacteria,2JJAS@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD1_k127_1252583_50	1340493.JNIF01000003_gene3205	8.733e-29	115.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_1270891_15	771875.Ferpe_0008	2.973e-40	153.0	COG0432@1|root,COG0432@2|Bacteria,2GD2P@200918|Thermotogae	200918|Thermotogae	S	PFAM Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_1270891_6	1122604.JONR01000025_gene4602	9.172e-170	554.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_1270891_20	1163409.UUA_10506	3.541e-17	87.0	2CH9S@1|root,2ZGJY@2|Bacteria,1P9NA@1224|Proteobacteria,1SUCK@1236|Gammaproteobacteria,1XBSP@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1270891_16	383372.Rcas_4129	2.124e-33	136.0	COG0823@1|root,COG0823@2|Bacteria,2G8PZ@200795|Chloroflexi,377MH@32061|Chloroflexia	32061|Chloroflexia	U	WD40 domain protein beta Propeller	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40
HKD1_k127_1270891_19	316274.Haur_0012	5.059e-18	90.0	COG0823@1|root,COG0823@2|Bacteria,2GAJ0@200795|Chloroflexi,376FZ@32061|Chloroflexia	32061|Chloroflexia	U	PFAM WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_1270891_0	1173028.ANKO01000086_gene1	0.0	1235.0	COG1020@1|root,COG1020@2|Bacteria,1G0XE@1117|Cyanobacteria	1117|Cyanobacteria	Q	Amino acid adenylation domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,Condensation,PP-binding,Thioesterase
HKD1_k127_1270891_2	1382306.JNIM01000001_gene1447	6.097e-187	594.0	COG2124@1|root,COG2124@2|Bacteria	2|Bacteria	Q	cytochrome p450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_1270891_5	1382306.JNIM01000001_gene1448	1.326e-175	570.0	COG1020@1|root,COG1020@2|Bacteria,2G86H@200795|Chloroflexi	200795|Chloroflexi	Q	PFAM AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C,PP-binding
HKD1_k127_1270891_12	1340493.JNIF01000004_gene505	4.372e-47	185.0	COG2304@1|root,COG2304@2|Bacteria,3Y3QQ@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD1_k127_1270891_1	452637.Oter_4609	4.725e-287	904.0	COG1297@1|root,COG1297@2|Bacteria	2|Bacteria	S	iron-nicotianamine transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD1_k127_1270891_23	1003200.AXXA_12250	0.0001936	52.0	COG4786@1|root,COG4786@2|Bacteria,1MZXB@1224|Proteobacteria,2VKSZ@28216|Betaproteobacteria,3T7AU@506|Alcaligenaceae	28216|Betaproteobacteria	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD1_k127_1270891_17	639030.JHVA01000001_gene91	2.076e-29	126.0	COG2006@1|root,COG2006@2|Bacteria,3Y7N1@57723|Acidobacteria,2JNKP@204432|Acidobacteriia	204432|Acidobacteriia	S	Carbohydrate family 9 binding domain-like	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD1_k127_1270891_3	945713.IALB_2638	5.578e-183	591.0	COG1132@1|root,COG1132@2|Bacteria	2|Bacteria	V	(ABC) transporter	MdlB	-	-	ko:K06147,ko:K18890	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106,3.A.1.106.13,3.A.1.106.5,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1270891_4	1198114.AciX9_1400	5.389e-179	578.0	COG1132@1|root,COG1132@2|Bacteria,3Y32T@57723|Acidobacteria,2JIBZ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter, transmembrane	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HKD1_k127_1270891_13	1122604.JONR01000060_gene2304	1.25e-42	176.0	COG2199@1|root,COG2202@1|root,COG2202@2|Bacteria,COG3706@2|Bacteria,1NECV@1224|Proteobacteria,1S0P0@1236|Gammaproteobacteria,1XCDA@135614|Xanthomonadales	135614|Xanthomonadales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,PAS_3
HKD1_k127_1270891_22	316056.RPC_2973	2.476e-10	67.0	COG2050@1|root,COG2050@2|Bacteria,1RDVV@1224|Proteobacteria,2UANF@28211|Alphaproteobacteria,3K1BX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_1270891_14	316274.Haur_0239	1.529e-40	156.0	COG0393@1|root,COG0393@2|Bacteria	2|Bacteria	S	Putative heavy-metal-binding	ybjQ	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD1_k127_1270891_18	1288484.APCS01000033_gene2398	1.133e-23	105.0	COG3695@1|root,COG3695@2|Bacteria	2|Bacteria	L	enzyme binding	ogt	-	2.1.1.63	ko:K00567,ko:K07443	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1,YjbR
HKD1_k127_1270891_10	443144.GM21_3621	5.029e-58	208.0	COG1878@1|root,COG1878@2|Bacteria,1P8U5@1224|Proteobacteria,42SY1@68525|delta/epsilon subdivisions,2WPQ7@28221|Deltaproteobacteria,43V12@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Putative cyclase	-	-	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HKD1_k127_1270891_11	204669.Acid345_3342	1.081e-49	187.0	COG1427@1|root,COG1427@2|Bacteria,3Y3PU@57723|Acidobacteria,2JIWB@204432|Acidobacteriia	204432|Acidobacteriia	S	Catalyzes the dehydration of chorismate into 3- (1- carboxyvinyl)oxy benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnA	-	4.2.1.151	ko:K11782	ko00130,ko01110,map00130,map01110	-	R10666	RC03232	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD1_k127_1270891_9	565045.NOR51B_614	9.104e-133	437.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,1RN0W@1236|Gammaproteobacteria,1J4KM@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	aminopeptidase	pepP	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD1_k127_1270891_7	204669.Acid345_1443	2.654e-137	454.0	COG1012@1|root,COG1012@2|Bacteria,3Y6J2@57723|Acidobacteria,2JMD6@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldehyde dehydrogenase family	-	-	1.2.99.10	ko:K22445	-	-	-	-	ko00000,ko01000	-	-	-	Aldedh
HKD1_k127_1270891_8	1163409.UUA_03818	1.892e-135	450.0	COG3055@1|root,COG3055@2|Bacteria,1NHAC@1224|Proteobacteria,1RYBY@1236|Gammaproteobacteria,1XAGU@135614|Xanthomonadales	135614|Xanthomonadales	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1326452_14	179408.Osc7112_2619	1.257e-53	215.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H8D7@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_12,TPR_7
HKD1_k127_1326452_26	714083.JH370377_gene2642	6.791e-05	54.0	COG1191@1|root,COG1191@2|Bacteria,2GKSY@201174|Actinobacteria,4FPF5@85023|Microbacteriaceae	201174|Actinobacteria	K	Sigma-70 region 3	-	-	-	ko:K02405,ko:K03090	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_1326452_27	582515.KR51_00018040	0.0001133	50.0	COG4243@1|root,COG4243@2|Bacteria,1FZWT@1117|Cyanobacteria	1117|Cyanobacteria	CO	PFAM Vitamin K epoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	VKOR
HKD1_k127_1326452_19	1226325.HMPREF1548_03424	9.444e-21	97.0	COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24JJB@186801|Clostridia,36K2M@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	ydeP	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_1326452_2	1267535.KB906767_gene1738	8.866e-126	425.0	COG3829@1|root,COG3829@2|Bacteria,3Y6K2@57723|Acidobacteria	57723|Acidobacteria	KT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
HKD1_k127_1326452_3	926566.Terro_1969	6.867e-124	412.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria,2JIG9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1326452_0	204669.Acid345_3357	7.957e-174	583.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA,HisKA_7TM,PAS,PAS_4
HKD1_k127_1326452_25	1382359.JIAL01000001_gene2868	6.033e-05	56.0	COG3485@1|root,COG3485@2|Bacteria,3Y44E@57723|Acidobacteria,2JIGS@204432|Acidobacteriia	204432|Acidobacteriia	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_1326452_6	401053.AciPR4_1386	4.362e-104	352.0	COG0612@1|root,COG0612@2|Bacteria,3Y3M9@57723|Acidobacteria,2JHY4@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the peptidase M16 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_1326452_13	204669.Acid345_4326	6.233e-63	227.0	COG1235@1|root,COG1235@2|Bacteria,3Y3DW@57723|Acidobacteria,2JI3X@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_1326452_24	309807.SRU_2723	3.266e-05	51.0	COG2771@1|root,COG2771@2|Bacteria,4P8PB@976|Bacteroidetes	976|Bacteroidetes	K	Protein of unknown function (DUF4019)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4019
HKD1_k127_1326452_1	316067.Geob_2894	1.282e-168	540.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,42MYS@68525|delta/epsilon subdivisions,2WJ2E@28221|Deltaproteobacteria,43TS7@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD1_k127_1326452_23	1382306.JNIM01000001_gene3910	6.163e-12	71.0	COG4818@1|root,COG4818@2|Bacteria,2G9D6@200795|Chloroflexi	200795|Chloroflexi	S	TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
HKD1_k127_1326452_21	647113.Metok_0976	4.228e-15	81.0	COG4818@1|root,arCOG04344@2157|Archaea,2Y0G5@28890|Euryarchaeota,23RV2@183939|Methanococci	183939|Methanococci	S	Domain of unknown function (DUF4870)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4870
HKD1_k127_1326452_18	1238182.C882_1353	2.722e-21	95.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2JTEV@204441|Rhodospirillales	204441|Rhodospirillales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD1_k127_1326452_8	204669.Acid345_2235	3.59e-97	322.0	COG0047@1|root,COG0047@2|Bacteria,3Y2YN@57723|Acidobacteria,2JIBA@204432|Acidobacteriia	204432|Acidobacteriia	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD1_k127_1326452_15	526225.Gobs_1802	3.105e-39	154.0	COG0664@1|root,COG1651@1|root,COG3004@1|root,COG0664@2|Bacteria,COG1651@2|Bacteria,COG3004@2|Bacteria,2GKIK@201174|Actinobacteria,4ESBH@85013|Frankiales	201174|Actinobacteria	OP	) H( ) antiporter that extrudes sodium in exchange for external protons	nhaA	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiport_1,Thioredoxin_4
HKD1_k127_1326452_9	1267535.KB906767_gene4333	6.576e-97	342.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria,3Y3C5@57723|Acidobacteria,2JI5M@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_11,TPR_16
HKD1_k127_1326452_10	861299.J421_0916	4.161e-94	325.0	COG0612@1|root,COG0612@2|Bacteria,1ZSVK@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_1326452_12	517418.Ctha_1581	6.526e-74	268.0	COG0612@1|root,COG0612@2|Bacteria,1FEWA@1090|Chlorobi	1090|Chlorobi	S	Peptidase M16 inactive domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_1326452_4	886293.Sinac_2843	2.911e-116	383.0	COG1680@1|root,COG2173@1|root,COG1680@2|Bacteria,COG2173@2|Bacteria,2IWSU@203682|Planctomycetes	203682|Planctomycetes	MV	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Peptidase_M15
HKD1_k127_1326452_5	1198452.Jab_1c23870	9.154e-109	367.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2VRVE@28216|Betaproteobacteria,475TS@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_1326452_7	1035308.AQYY01000002_gene1056	7.044e-104	348.0	2DB7V@1|root,2Z7NX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1326452_16	452652.KSE_02830	2.349e-22	104.0	COG2954@1|root,COG2954@2|Bacteria,2IHDK@201174|Actinobacteria,2M36J@2063|Kitasatospora	201174|Actinobacteria	S	triphosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1326452_17	1230343.CANP01000024_gene1876	3.246e-22	109.0	COG0726@1|root,COG0726@2|Bacteria,1NHC2@1224|Proteobacteria,1SGBD@1236|Gammaproteobacteria,1JCCV@118969|Legionellales	118969|Legionellales	G	Protein of unknown function (DUF3298)	yjeA	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
HKD1_k127_1326452_20	1002339.HMPREF9373_0280	2.138e-15	80.0	COG3071@1|root,COG3071@2|Bacteria,1N6Y8@1224|Proteobacteria,1SFVY@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	Protein of unknown function (DUF2905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2905
HKD1_k127_1326452_11	1232410.KI421421_gene3851	2.68e-81	279.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,42P3I@68525|delta/epsilon subdivisions,2WM37@28221|Deltaproteobacteria,43TDJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD1_k127_1326452_28	981327.F925_00386	0.0003382	52.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,1S1K1@1236|Gammaproteobacteria,3NKRQ@468|Moraxellaceae	1236|Gammaproteobacteria	S	TPM domain	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_1390984_14	671143.DAMO_3015	7.271e-81	290.0	COG2844@1|root,COG2844@2|Bacteria	2|Bacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD1_k127_1390984_15	497964.CfE428DRAFT_5003	2.126e-43	160.0	COG0347@1|root,COG0347@2|Bacteria	2|Bacteria	K	Belongs to the P(II) protein family	-	-	-	ko:K04751,ko:K04752	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD1_k127_1390984_9	1267535.KB906767_gene640	4.426e-204	646.0	COG0004@1|root,COG0004@2|Bacteria,3Y2VR@57723|Acidobacteria,2JHMR@204432|Acidobacteriia	204432|Acidobacteriia	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_1390984_5	1242864.D187_004920	1.386e-226	715.0	COG3604@1|root,COG3604@2|Bacteria,1QTT3@1224|Proteobacteria,42Y69@68525|delta/epsilon subdivisions,2WJ5F@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02584	ko02020,map02020	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,HTH_8,Sigma54_activat
HKD1_k127_1390984_1	1047013.AQSP01000113_gene740	0.0	1069.0	COG1472@1|root,COG1472@2|Bacteria,2NNR4@2323|unclassified Bacteria	2|Bacteria	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HKD1_k127_1390984_3	452637.Oter_3545	5.999e-293	906.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	xynB	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	DUF1349,Glyco_hydro_43
HKD1_k127_1390984_8	234267.Acid_5646	1.434e-204	646.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HKD1_k127_1390984_13	1267534.KB906755_gene4156	5.675e-136	441.0	COG0673@1|root,COG0673@2|Bacteria,3Y6Z2@57723|Acidobacteria,2JMN3@204432|Acidobacteriia	204432|Acidobacteriia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_1390984_10	926569.ANT_05060	3.143e-182	577.0	COG2115@1|root,COG2115@2|Bacteria,2G688@200795|Chloroflexi	200795|Chloroflexi	G	PFAM Xylose isomerase domain protein TIM barrel	xylA	-	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_1390984_11	234267.Acid_2681	3.615e-172	546.0	COG3693@1|root,COG3693@2|Bacteria,3Y6EW@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_10
HKD1_k127_1390984_16	234267.Acid_2680	1.439e-29	121.0	COG2211@1|root,COG2211@2|Bacteria,3Y7MD@57723|Acidobacteria	57723|Acidobacteria	G	MFS/sugar transport protein	-	-	-	-	-	-	-	-	-	-	-	-	MFS_2
HKD1_k127_1390984_0	234267.Acid_2679	0.0	1210.0	COG1472@1|root,COG1472@2|Bacteria,3Y3QE@57723|Acidobacteria	57723|Acidobacteria	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_1390984_12	1267535.KB906767_gene3252	5.532e-144	469.0	COG1904@1|root,COG1904@2|Bacteria	2|Bacteria	G	glucuronate isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1390984_6	234267.Acid_2667	1.168e-221	692.0	COG4948@1|root,COG4948@2|Bacteria,3Y4P2@57723|Acidobacteria	57723|Acidobacteria	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	4.2.1.40	ko:K01706	ko00053,ko01100,map00053,map01100	-	R02752,R08056	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_1390984_2	518766.Rmar_1079	6.047e-298	930.0	COG3661@1|root,COG3661@2|Bacteria,4NHE2@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 67 family	-	-	3.2.1.139	ko:K01235	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_67C,Glyco_hydro_67M,Glyco_hydro_67N
HKD1_k127_1390984_7	1123073.KB899241_gene3395	4.826e-209	662.0	COG0624@1|root,COG0624@2|Bacteria,1R96A@1224|Proteobacteria,1RSD6@1236|Gammaproteobacteria,1X5K9@135614|Xanthomonadales	135614|Xanthomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_1390984_4	761193.Runsl_2134	2.66e-232	726.0	COG4225@1|root,COG4225@2|Bacteria,4NH7G@976|Bacteroidetes,47N5K@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl Hydrolase Family 88	yteR_9	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88,Lipase_GDSL_2
HKD1_k127_1390984_17	497964.CfE428DRAFT_1207	0.0002643	43.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_1403771_31	56110.Oscil6304_5587	3.302e-78	275.0	COG2848@1|root,COG2848@2|Bacteria,1G3IK@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
HKD1_k127_1403771_14	234267.Acid_3898	1.768e-144	484.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria	2|Bacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,VWA,VWA_2
HKD1_k127_1403771_11	204669.Acid345_2716	4.385e-148	506.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_1403771_8	1379698.RBG1_1C00001G0607	5.884e-169	558.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_1403771_41	502025.Hoch_1576	4.54e-58	209.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_1403771_42	1158338.JNLJ01000001_gene295	1.352e-55	203.0	COG0283@1|root,COG0283@2|Bacteria,2G3Z6@200783|Aquificae	200783|Aquificae	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD1_k127_1403771_39	469371.Tbis_1372	8.197e-60	213.0	COG0307@1|root,COG0307@2|Bacteria,2GKC5@201174|Actinobacteria,4E2BN@85010|Pseudonocardiales	201174|Actinobacteria	H	Riboflavin synthase	ribE	GO:0003674,GO:0003824,GO:0004746,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD1_k127_1403771_18	269799.Gmet_1626	1.248e-137	452.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1MU8P@1224|Proteobacteria,42N1C@68525|delta/epsilon subdivisions,2WIP5@28221|Deltaproteobacteria,43U14@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_1403771_48	1340493.JNIF01000003_gene3620	3.19e-43	184.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	AsmA_2,DUF748,TamB
HKD1_k127_1403771_38	204669.Acid345_2804	1.851e-61	243.0	COG4775@1|root,COG4775@2|Bacteria,3Y2RF@57723|Acidobacteria,2JHK5@204432|Acidobacteriia	57723|Acidobacteria	M	surface antigen variable number	-	-	-	-	-	-	-	-	-	-	-	-	Bac_surface_Ag,POTRA
HKD1_k127_1403771_82	926566.Terro_3238	7.906e-06	56.0	COG0760@1|root,COG0760@2|Bacteria,3Y4KY@57723|Acidobacteria,2JJDJ@204432|Acidobacteriia	204432|Acidobacteriia	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	SurA_N_3
HKD1_k127_1403771_49	1336243.JAEA01000014_gene3653	1.012e-42	160.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2U05I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD1_k127_1403771_79	926690.KE386573_gene2957	1.559e-09	64.0	arCOG09205@1|root,arCOG09205@2157|Archaea,2XVYM@28890|Euryarchaeota,23VNM@183963|Halobacteria	183963|Halobacteria	S	Domain of unknown function (DUF309)	-	-	-	-	-	-	-	-	-	-	-	-	DUF309
HKD1_k127_1403771_78	204669.Acid345_3199	1.427e-09	65.0	2ED8Q@1|root,33759@2|Bacteria,3Y5NT@57723|Acidobacteria,2JJWR@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4149)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4149
HKD1_k127_1403771_57	443143.GM18_3141	9.532e-31	131.0	2DQBG@1|root,335T7@2|Bacteria,1R35T@1224|Proteobacteria,42ZVK@68525|delta/epsilon subdivisions,2WV6B@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	1.21.4.1	ko:K10794	ko00330,map00330	-	R02825	RC00790	ko00000,ko00001,ko01000	-	-	-	GRDB
HKD1_k127_1403771_25	1122604.JONR01000033_gene2	1.309e-107	360.0	COG3386@1|root,COG3386@2|Bacteria,1MX7V@1224|Proteobacteria,1RMQK@1236|Gammaproteobacteria,1X4YM@135614|Xanthomonadales	135614|Xanthomonadales	G	Strictosidine synthase	-	-	-	-	-	-	-	-	-	-	-	-	Str_synth
HKD1_k127_1403771_70	159087.Daro_3724	7.461e-21	95.0	COG1145@1|root,COG1145@2|Bacteria,1MZ6H@1224|Proteobacteria,2VTZ1@28216|Betaproteobacteria,2KX13@206389|Rhodocyclales	206389|Rhodocyclales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_1403771_64	861299.J421_4429	3.659e-24	107.0	COG0824@1|root,COG0824@2|Bacteria,1ZV5K@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT
HKD1_k127_1403771_77	530564.Psta_2919	9.73e-10	67.0	COG5349@1|root,COG5349@2|Bacteria,2J1NF@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HKD1_k127_1403771_5	1242864.D187_007079	5.68e-200	639.0	COG0457@1|root,COG0457@2|Bacteria,1NTKG@1224|Proteobacteria	1224|Proteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_69	1123269.NX02_17455	2.036e-21	100.0	COG0515@1|root,COG0515@2|Bacteria,1Q7XV@1224|Proteobacteria,2UZM2@28211|Alphaproteobacteria,2KBWM@204457|Sphingomonadales	204457|Sphingomonadales	KLT	serine threonine protein kinase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_2	926566.Terro_0850	3.405e-283	888.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_1403771_45	935840.JAEQ01000019_gene2103	4.114e-47	173.0	COG2080@1|root,COG2080@2|Bacteria,1RB3F@1224|Proteobacteria,2VF0C@28211|Alphaproteobacteria,43PPP@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase small subunit CoxS	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_1403771_32	1267534.KB906759_gene1949	6.053e-74	258.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.17.1.4	ko:K13479	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_1403771_67	1200792.AKYF01000010_gene2397	1.058e-21	108.0	2DKY8@1|root,30VAD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TIG
HKD1_k127_1403771_85	246196.MSMEI_5130	3.609e-05	55.0	COG5473@1|root,COG5473@2|Bacteria,2GN5K@201174|Actinobacteria,234B0@1762|Mycobacteriaceae	201174|Actinobacteria	J	Zn-ribbon protein possibly nucleic acid-binding	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_7	448385.sce5876	5.234e-171	548.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42RF2@68525|delta/epsilon subdivisions,2WP05@28221|Deltaproteobacteria,2YWCM@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	allB	-	3.5.2.5	ko:K01466	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02425	RC00680	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_1403771_15	1254432.SCE1572_35005	3.928e-141	455.0	COG3195@1|root,COG4266@1|root,COG3195@2|Bacteria,COG4266@2|Bacteria,1MXJK@1224|Proteobacteria,42YE0@68525|delta/epsilon subdivisions,2X30N@28221|Deltaproteobacteria,2YTWS@29|Myxococcales	28221|Deltaproteobacteria	F	Belongs to the allantoicase family	alc	-	3.5.3.4	ko:K01477	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R02422	RC00379,RC00712	ko00000,ko00001,ko00002,ko01000	-	-	-	Allantoicase,OHCU_decarbox
HKD1_k127_1403771_65	1479237.JMLY01000001_gene2639	2.997e-23	105.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_1403771_60	1086011.HJ01_03285	1.305e-27	117.0	COG0589@1|root,COG0589@2|Bacteria,4NJ0H@976|Bacteroidetes,1I0HV@117743|Flavobacteriia	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1403771_76	1403313.AXBR01000005_gene1806	6.524e-10	67.0	COG3751@1|root,COG3751@2|Bacteria,1UNHV@1239|Firmicutes,4HEJV@91061|Bacilli,1ZEH2@1386|Bacillus	91061|Bacilli	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	1.14.11.2	ko:K00472	ko00330,ko01100,map00330,map01100	-	R01252	RC00478	ko00000,ko00001,ko01000	-	-	-	2OG-FeII_Oxy_3
HKD1_k127_1403771_35	204669.Acid345_3369	1.324e-64	251.0	COG0515@1|root,COG0515@2|Bacteria	204669.Acid345_3369|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD1_k127_1403771_21	1267534.KB906755_gene4470	6.764e-131	452.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y7SS@57723|Acidobacteria,2JMXC@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD1_k127_1403771_19	316274.Haur_0966	8.724e-135	454.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	LTD,PKD,Reprolysin_4,Reprolysin_5
HKD1_k127_1403771_66	588581.Cpap_3810	5.181e-22	109.0	COG2120@1|root,COG2120@2|Bacteria,1UUR1@1239|Firmicutes,257J2@186801|Clostridia,3WR4X@541000|Ruminococcaceae	186801|Clostridia	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_1403771_40	1906.SFRA_20540	3.248e-59	223.0	arCOG02075@1|root,33AGA@2|Bacteria	2|Bacteria	S	NnrS protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrS
HKD1_k127_1403771_63	266117.Rxyl_1199	1.954e-24	109.0	COG2846@1|root,COG2846@2|Bacteria	2|Bacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858,Hemerythrin,NnrS
HKD1_k127_1403771_34	204669.Acid345_0365	1.325e-65	231.0	COG2846@1|root,COG2846@2|Bacteria,3Y4SU@57723|Acidobacteria,2JMU3@204432|Acidobacteriia	204432|Acidobacteriia	D	Domain of Unknown function (DUF542)	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD1_k127_1403771_24	42256.RradSPS_0572	2.252e-119	396.0	COG2223@1|root,COG2223@2|Bacteria,2GJ1I@201174|Actinobacteria,4CQM5@84995|Rubrobacteria	84995|Rubrobacteria	P	Major Facilitator Superfamily	-	-	-	ko:K02575	ko00910,map00910	M00615	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.8	-	-	MFS_1
HKD1_k127_1403771_16	1254432.SCE1572_23370	4.682e-141	458.0	COG2223@1|root,COG2223@2|Bacteria	2|Bacteria	P	nitrite transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_1	1254432.SCE1572_23375	0.0	1142.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2X7DH@28221|Deltaproteobacteria,2YWG8@29|Myxococcales	2|Bacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	nasC	-	-	ko:K00372	ko00910,ko01120,map00910,map01120	M00531	R00798,R01106	RC02812	ko00000,ko00001,ko00002,ko01000	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_1403771_26	1254432.SCE1572_23380	2.977e-96	319.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_11,Fer4_4
HKD1_k127_1403771_36	1254432.SCE1572_23385	2.627e-63	222.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD1_k127_1403771_71	316274.Haur_1542	1.238e-17	84.0	2DDP8@1|root,2ZISD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_17	926550.CLDAP_36880	1.218e-138	450.0	COG0167@1|root,COG0167@2|Bacteria,2G5T6@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the conversion of dihydroorotate to orotate	-	-	1.3.98.1	ko:K00226	ko00240,ko01100,map00240,map01100	M00051	R01867	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_1403771_0	926550.CLDAP_36890	0.0	1743.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1146@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1146@2|Bacteria,2G5M1@200795|Chloroflexi	200795|Chloroflexi	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	porA	-	1.2.7.1	ko:K00169,ko:K03737	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034,R10866	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_6,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_1403771_55	240016.ABIZ01000001_gene5378	3.184e-35	140.0	COG0071@1|root,COG0071@2|Bacteria,46T3G@74201|Verrucomicrobia,2IVVF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_1403771_50	204669.Acid345_1498	3.016e-42	164.0	COG0664@1|root,COG0664@2|Bacteria,3Y4IX@57723|Acidobacteria,2JJ9U@204432|Acidobacteriia	204432|Acidobacteriia	K	cyclic nucleotide-binding	-	-	-	ko:K01420,ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_1403771_27	204669.Acid345_3828	1.921e-93	317.0	COG3303@1|root,COG3303@2|Bacteria,3Y999@57723|Acidobacteria,2JP5G@204432|Acidobacteriia	204432|Acidobacteriia	C	Doubled CXXCH motif (Paired_CXXCH_1)	-	-	-	-	-	-	-	-	-	-	-	-	Paired_CXXCH_1
HKD1_k127_1403771_46	1340493.JNIF01000003_gene1663	2.094e-46	191.0	28MCK@1|root,2ZAQP@2|Bacteria,3Y41I@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_44	1379698.RBG1_1C00001G0781	2.479e-51	187.0	COG0723@1|root,COG0723@2|Bacteria,2NQ46@2323|unclassified Bacteria	2|Bacteria	C	Rieske [2Fe-2S] domain	petA	-	1.10.2.2,1.10.9.1	ko:K00411,ko:K02636,ko:K03886	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	iAF987.Gmet_1922	CytB6-F_Fe-S,Rieske,UCR_Fe-S_N
HKD1_k127_1403771_13	1379698.RBG1_1C00001G0780	8.369e-146	469.0	COG1290@1|root,COG1290@2|Bacteria,2NP8C@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome b(N-terminal)/b6/petB	petB	-	-	ko:K00410,ko:K00412,ko:K02635,ko:K02637	ko00190,ko00195,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map00195,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152,M00162	-	-	ko00000,ko00001,ko00002,ko00194,ko03029	-	-	-	Cytochrom_B_C,Cytochrom_C1,Cytochrome_B
HKD1_k127_1403771_22	671143.DAMO_0822	7.063e-124	415.0	COG2864@1|root,COG2864@2|Bacteria,2NQBN@2323|unclassified Bacteria	2|Bacteria	C	Cytochrome c554 and c-prime	-	-	-	ko:K03620	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Cytochrom_c3_2,Cytochrome_C554,Ni_hydr_CYTB
HKD1_k127_1403771_86	457398.HMPREF0326_00619	5.827e-05	55.0	29W60@1|root,30HR4@2|Bacteria,1RJNX@1224|Proteobacteria,42T35@68525|delta/epsilon subdivisions,2WP20@28221|Deltaproteobacteria,2M98P@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Class III cytochrome C family	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_CIII
HKD1_k127_1403771_74	243231.GSU1996	5.874e-11	74.0	COG3005@1|root,COG3005@2|Bacteria,1NJY9@1224|Proteobacteria,42XJ4@68525|delta/epsilon subdivisions,2WSQ4@28221|Deltaproteobacteria,43TRS@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	heme-binding sites	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_1403771_53	880072.Desac_0990	9.745e-39	155.0	COG0509@1|root,COG0509@2|Bacteria,1Q1KI@1224|Proteobacteria,437BG@68525|delta/epsilon subdivisions,2X2GI@28221|Deltaproteobacteria,2MRJR@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	PFAM glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
HKD1_k127_1403771_61	1265505.ATUG01000002_gene1876	3.19e-27	120.0	COG0509@1|root,COG0509@2|Bacteria,1NRFW@1224|Proteobacteria,42ZAN@68525|delta/epsilon subdivisions,2WUQI@28221|Deltaproteobacteria,2MMY2@213118|Desulfobacterales	28221|Deltaproteobacteria	E	Glycine cleavage H-protein	-	-	-	-	-	-	-	-	-	-	-	-	GCV_H
HKD1_k127_1403771_29	945713.IALB_2426	6.521e-86	293.0	COG0437@1|root,COG0437@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	fdnH	-	-	ko:K00124	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001	-	-	-	Fer4_11,Fer4_3,Fer4_4
HKD1_k127_1403771_20	234267.Acid_4205	8.87e-134	444.0	COG5557@1|root,COG5557@2|Bacteria,3Y3RF@57723|Acidobacteria	57723|Acidobacteria	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	NrfD
HKD1_k127_1403771_84	443143.GM18_3675	2.948e-05	57.0	COG3005@1|root,COG3005@2|Bacteria,1NJY9@1224|Proteobacteria,42XJ4@68525|delta/epsilon subdivisions,2WSQ4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	12 heme-binding sites	cbcC	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_1403771_23	234267.Acid_4206	1.855e-121	412.0	COG4191@1|root,COG4191@2|Bacteria,3Y42C@57723|Acidobacteria	57723|Acidobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	2.7.13.3	ko:K02482	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1403771_10	234267.Acid_4207	9.311e-162	522.0	COG2204@1|root,COG2204@2|Bacteria,3Y3T2@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1403771_47	204669.Acid345_2605	5.329e-46	172.0	COG1913@1|root,COG1913@2|Bacteria,3Y880@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M54	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
HKD1_k127_1403771_6	204669.Acid345_2713	9.056e-178	578.0	COG0484@1|root,COG2864@1|root,COG0484@2|Bacteria,COG2864@2|Bacteria,3Y6QW@57723|Acidobacteria	57723|Acidobacteria	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_c3_2,Ni_hydr_CYTB
HKD1_k127_1403771_9	204669.Acid345_2712	6.863e-164	531.0	COG3005@1|root,COG3005@2|Bacteria,3Y3MU@57723|Acidobacteria,2JJ6B@204432|Acidobacteriia	57723|Acidobacteria	C	NapC/NirT cytochrome c family, N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_NNT
HKD1_k127_1403771_73	234267.Acid_7861	6.314e-13	78.0	COG5343@1|root,COG5343@2|Bacteria,3Y4J0@57723|Acidobacteria	57723|Acidobacteria	S	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA
HKD1_k127_1403771_52	1144275.COCOR_04331	7.415e-40	154.0	COG1595@1|root,COG1595@2|Bacteria,1N00E@1224|Proteobacteria,432XU@68525|delta/epsilon subdivisions,2WXDM@28221|Deltaproteobacteria,2YVQ7@29|Myxococcales	28221|Deltaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_1403771_68	1267533.KB906733_gene3397	1.197e-21	110.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_1403771_58	1234595.C725_1665	1.635e-30	123.0	COG4323@1|root,COG4323@2|Bacteria,1N16T@1224|Proteobacteria,2U9EX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HKD1_k127_1403771_30	1379698.RBG1_1C00001G0812	9.644e-84	283.0	COG0177@1|root,COG0177@2|Bacteria,2NPBI@2323|unclassified Bacteria	2|Bacteria	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_1403771_4	1267535.KB906767_gene2350	2.335e-256	803.0	COG1217@1|root,COG1217@2|Bacteria,3Y33Q@57723|Acidobacteria,2JIIC@204432|Acidobacteriia	204432|Acidobacteriia	T	GTP-binding protein TypA	-	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_1403771_81	65393.PCC7424_0465	4.811e-06	54.0	COG0515@1|root,COG0515@2|Bacteria	65393.PCC7424_0465|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_80	1303518.CCALI_00917	1.837e-06	61.0	COG0457@1|root,COG0457@2|Bacteria	1303518.CCALI_00917|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_72	189753.AXAS01000016_gene1492	1.598e-13	76.0	2AKTJ@1|root,31BKK@2|Bacteria,1NYB1@1224|Proteobacteria,2UTN8@28211|Alphaproteobacteria,3K4H7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1403771_3	1254432.SCE1572_49835	7.318e-272	854.0	COG0065@1|root,COG0066@1|root,COG0065@2|Bacteria,COG0066@2|Bacteria,1MVYR@1224|Proteobacteria,42M5D@68525|delta/epsilon subdivisions,2WJ59@28221|Deltaproteobacteria,2YX5D@29|Myxococcales	28221|Deltaproteobacteria	E	Aconitase C-terminal domain	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_1403771_54	1337936.IJ00_21005	1.702e-35	142.0	COG1670@1|root,COG1670@2|Bacteria,1G6BV@1117|Cyanobacteria,1HP5J@1161|Nostocales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_1403771_12	1047013.AQSP01000079_gene2039	3.54e-147	474.0	2C57D@1|root,2Z7RS@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
HKD1_k127_1403771_56	1379270.AUXF01000002_gene1393	4.925e-35	139.0	2DRPS@1|root,33CHR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2204
HKD1_k127_1403771_28	1499967.BAYZ01000003_gene5884	2.762e-87	294.0	COG2454@1|root,COG2454@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
HKD1_k127_1403771_37	1121013.P873_12075	9.73e-63	223.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_1403771_59	391625.PPSIR1_19829	2.026e-30	125.0	COG2207@1|root,COG2207@2|Bacteria,1QKC9@1224|Proteobacteria,42TIX@68525|delta/epsilon subdivisions,2WP2M@28221|Deltaproteobacteria,2Z1YB@29|Myxococcales	28221|Deltaproteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,HTH_18
HKD1_k127_1403771_51	661478.OP10G_3245	7.011e-41	154.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_1403771_33	452471.Aasi_0623	3.132e-71	246.0	29KMP@1|root,2Z9ZF@2|Bacteria,4NKVK@976|Bacteroidetes,47QGW@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HKD1_k127_1403771_43	1379698.RBG1_1C00001G0272	1.926e-54	196.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,DUF2505
HKD1_k127_1462591_2	497964.CfE428DRAFT_3001	1.089e-43	180.0	COG1470@1|root,COG2911@1|root,COG2931@1|root,COG4412@1|root,COG4733@1|root,COG4932@1|root,COG1470@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4412@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	2.7.11.1,3.2.1.4	ko:K01179,ko:K12567,ko:K20276,ko:K21449	ko00500,ko01100,ko02024,ko05410,ko05414,map00500,map01100,map02024,map05410,map05414	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01001,ko02000,ko04131,ko04147,ko04812	1.B.40.2	GH5,GH9	-	DUF4347,HemolysinCabind,Peptidase_M30
HKD1_k127_1462591_8	1300143.CCAV010000001_gene1327	9.076e-14	85.0	COG1409@1|root,COG3325@1|root,COG4733@1|root,COG1409@2|Bacteria,COG3325@2|Bacteria,COG4733@2|Bacteria,4NGXK@976|Bacteroidetes,1I36R@117743|Flavobacteriia,3ZRBT@59732|Chryseobacterium	976|Bacteroidetes	G	Glycosyl hydrolases family 18	endOF1	-	-	-	-	-	-	-	-	-	-	-	DUF1735,Glyco_hydro_18,Laminin_G_3,fn3
HKD1_k127_1462591_1	1267535.KB906767_gene870	3.518e-78	300.0	COG3209@1|root,COG3209@2|Bacteria,3Y7FC@57723|Acidobacteria,2JKK9@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_1462591_12	1267005.KB911258_gene89	1.863e-07	66.0	2C1A0@1|root,2ZX64@2|Bacteria	2|Bacteria	S	Type VI secretion system (T6SS), amidase effector protein 4	-	-	-	-	-	-	-	-	-	-	-	-	Tae4
HKD1_k127_1462591_0	1089553.Tph_c20110	1.23e-123	412.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,42FT8@68295|Thermoanaerobacterales	186801|Clostridia	L	Transposase IS116 IS110 IS902 family protein	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_1462591_3	1340493.JNIF01000003_gene3378	8.731e-32	142.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	tccC1	-	-	ko:K11021	-	-	-	-	ko00000,ko02042	-	-	-	-
HKD1_k127_1462591_11	316067.Geob_3673	5.045e-08	64.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42R71@68525|delta/epsilon subdivisions,2WMW5@28221|Deltaproteobacteria,43SWS@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	RHS protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4150,RHS,RHS_repeat
HKD1_k127_1462591_4	682795.AciX8_4232	7.551e-28	133.0	COG3209@1|root,COG3209@2|Bacteria,3Y5Q3@57723|Acidobacteria,2JJZC@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_1462591_9	314254.OA2633_03791	1.314e-10	67.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,2U4RY@28211|Alphaproteobacteria,43YWV@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	TIGRFAM RHS repeat-associated core domain-containing protein, YD repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat,SpvB,TcdB_toxin_midN
HKD1_k127_1462591_7	439235.Dalk_0273	1.545e-14	88.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,42P9N@68525|delta/epsilon subdivisions,2WJSQ@28221|Deltaproteobacteria,2MIDQ@213118|Desulfobacterales	28221|Deltaproteobacteria	M	TIGRFAM RHS repeat-associated core	-	-	-	-	-	-	-	-	-	-	-	-	AHH,RHS_repeat,SpvB,TcdB_toxin_midC,TcdB_toxin_midN,VCBS
HKD1_k127_1462591_5	682795.AciX8_4232	1.221e-23	119.0	COG3209@1|root,COG3209@2|Bacteria,3Y5Q3@57723|Acidobacteria,2JJZC@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_1462591_6	926560.KE387023_gene3391	2.009e-18	88.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_148946_87	404589.Anae109_3266	1.082e-11	68.0	2DB8U@1|root,2Z7SW@2|Bacteria,1NQRP@1224|Proteobacteria	1224|Proteobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
HKD1_k127_148946_6	1122605.KB893648_gene3690	2.215e-231	734.0	28J61@1|root,2Z91S@2|Bacteria,4NKJU@976|Bacteroidetes	976|Bacteroidetes	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_129
HKD1_k127_148946_28	1089545.KB913037_gene6007	1.064e-130	429.0	COG4225@1|root,COG4225@2|Bacteria,2I8PZ@201174|Actinobacteria,4E052@85010|Pseudonocardiales	201174|Actinobacteria	G	Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
HKD1_k127_148946_4	886293.Sinac_4910	3.137e-239	757.0	COG1082@1|root,COG1082@2|Bacteria,2J24A@203682|Planctomycetes	203682|Planctomycetes	G	Glycosyl-hydrolase 97 N-terminal	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
HKD1_k127_148946_20	1267535.KB906767_gene895	5.97e-166	531.0	2DB8U@1|root,2Z7SW@2|Bacteria,3Y3IM@57723|Acidobacteria	57723|Acidobacteria	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
HKD1_k127_148946_21	861299.J421_5607	2.341e-162	524.0	COG3669@1|root,COG3669@2|Bacteria	2|Bacteria	G	Alpha-L-fucosidase	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,Fucosidase_C
HKD1_k127_148946_2	452637.Oter_0169	6.601e-267	837.0	COG4948@1|root,COG4948@2|Bacteria	2|Bacteria	M	carboxylic acid catabolic process	-	-	3.2.1.20	ko:K01187	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00028,R00801,R00802,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	GH31	-	GH97_C,GH97_N,Glyco_hydro_97
HKD1_k127_148946_39	1340493.JNIF01000003_gene1465	1.163e-99	334.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_148946_40	1267535.KB906767_gene2309	2.018e-95	321.0	COG0329@1|root,COG0329@2|Bacteria	2|Bacteria	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	kdgD	-	4.2.1.41	ko:K01707	ko00053,ko01100,map00053,map01100	-	R02279	RC00678	ko00000,ko00001,ko01000	-	-	-	DHDPS
HKD1_k127_148946_56	314230.DSM3645_07485	3.496e-74	260.0	COG0673@1|root,COG0673@2|Bacteria,2J216@203682|Planctomycetes	203682|Planctomycetes	S	dehydrogenases and related proteins	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_148946_46	279010.BL03436	3.717e-81	286.0	COG2271@1|root,COG2271@2|Bacteria,1TP6X@1239|Firmicutes,4HEVA@91061|Bacilli,1ZCX2@1386|Bacillus	91061|Bacilli	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	ko:K03535,ko:K08194	-	-	-	-	ko00000,ko02000	2.A.1.14.1,2.A.1.14.7	-	-	MFS_1
HKD1_k127_148946_3	570952.ATVH01000004_gene2592	6.912e-265	826.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,2JQ5K@204441|Rhodospirillales	204441|Rhodospirillales	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_148946_43	926549.KI421517_gene1534	7.709e-87	299.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_148946_9	1340493.JNIF01000004_gene88	3.102e-223	738.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HKD1_k127_148946_5	1382359.JIAL01000001_gene74	9.68e-234	767.0	COG3485@1|root,COG3485@2|Bacteria	2|Bacteria	Q	protocatechuate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Dioxygenase_C
HKD1_k127_148946_11	234267.Acid_4210	2.53e-208	655.0	COG3669@1|root,COG3669@2|Bacteria,3Y43P@57723|Acidobacteria	57723|Acidobacteria	G	PFAM glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
HKD1_k127_148946_48	1382304.JNIL01000001_gene2460	1.185e-80	278.0	COG3618@1|root,COG3618@2|Bacteria,1URZE@1239|Firmicutes,4HAYX@91061|Bacilli	91061|Bacilli	S	amidohydrolase	-	-	-	ko:K07046	ko00051,ko01120,map00051,map01120	-	R10689	RC00537	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HKD1_k127_148946_41	1210884.HG799478_gene15504	3.291e-89	304.0	COG0451@1|root,COG0451@2|Bacteria,2IYKN@203682|Planctomycetes	203682|Planctomycetes	M	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_148946_23	56107.Cylst_1796	1.898e-147	477.0	COG1063@1|root,COG1063@2|Bacteria,1G360@1117|Cyanobacteria,1HJDW@1161|Nostocales	2|Bacteria	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.103,1.1.1.14	ko:K00008,ko:K00060	ko00040,ko00051,ko00260,ko01100,map00040,map00051,map00260,map01100	M00014	R00875,R01465,R01896	RC00085,RC00102,RC00525	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_148946_45	439292.Bsel_2453	1.688e-81	278.0	COG0247@1|root,COG0247@2|Bacteria,1TPFC@1239|Firmicutes,4HAKC@91061|Bacilli,26NE3@186821|Sporolactobacillaceae	91061|Bacilli	C	Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source	lutA	-	-	ko:K18928	-	-	-	-	ko00000	-	-	-	CCG
HKD1_k127_148946_26	861299.J421_5609	2.798e-135	438.0	COG1879@1|root,COG1879@2|Bacteria,1ZV3Z@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	Periplasmic binding proteins and sugar binding domain of LacI family	-	-	-	ko:K10439,ko:K10552	ko02010,ko02030,map02010,map02030	M00212,M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.7	-	-	Peripla_BP_4
HKD1_k127_148946_27	861299.J421_5600	3.755e-132	429.0	COG1172@1|root,COG1172@2|Bacteria,1ZUX9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	Branched-chain amino acid transport system / permease component	-	-	-	ko:K10440,ko:K10553	ko02010,map02010	M00212,M00218	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.7	-	-	BPD_transp_2
HKD1_k127_148946_22	530564.Psta_3462	3.486e-148	476.0	COG0667@1|root,COG0667@2|Bacteria,2IYAG@203682|Planctomycetes	203682|Planctomycetes	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_148946_13	1071679.BG57_27385	4.732e-204	645.0	COG4948@1|root,COG4948@2|Bacteria,1MYZE@1224|Proteobacteria,2VMKY@28216|Betaproteobacteria,1K19C@119060|Burkholderiaceae	28216|Betaproteobacteria	M	mandelate racemase muconate lactonizing	-	-	4.2.1.68	ko:K18334	ko00051,ko01120,map00051,map01120	-	R03688	RC00543	ko00000,ko00001,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_148946_17	861299.J421_5610	4.285e-180	576.0	COG1129@1|root,COG1129@2|Bacteria,1ZVAU@142182|Gemmatimonadetes	2|Bacteria	G	ABC transporter	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD1_k127_148946_49	1267535.KB906767_gene4788	2.09e-80	275.0	COG2755@1|root,COG2755@2|Bacteria,3Y4BD@57723|Acidobacteria,2JMAI@204432|Acidobacteriia	204432|Acidobacteriia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_148946_52	1267535.KB906767_gene432	4.376e-79	276.0	COG1609@1|root,COG1609@2|Bacteria,3Y44C@57723|Acidobacteria,2JKN3@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn _helix lactose operon repressor	-	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD1_k127_148946_1	234267.Acid_2735	1.519e-296	934.0	COG1331@1|root,COG1331@2|Bacteria	2|Bacteria	O	Highly conserved protein containing a thioredoxin domain	ugl	-	3.2.1.180	ko:K18581	-	-	R10867	RC00049,RC02427	ko00000,ko01000	-	GH88	-	Glyco_hydro_88
HKD1_k127_148946_44	234267.Acid_2736	6.367e-85	291.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD1_k127_148946_83	1198114.AciX9_2244	1.398e-17	90.0	COG2140@1|root,COG2140@2|Bacteria	2|Bacteria	G	oxalate decarboxylase activity	-	-	-	ko:K11312	-	-	-	-	ko00000	-	-	-	Cupin_2,Cupin_8
HKD1_k127_148946_18	1124780.ANNU01000071_gene1021	2.745e-174	561.0	COG2271@1|root,COG2271@2|Bacteria,4NE7R@976|Bacteroidetes,47JBJ@768503|Cytophagia	976|Bacteroidetes	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1,Sugar_tr
HKD1_k127_148946_38	1254432.SCE1572_20570	1.137e-99	332.0	COG1028@1|root,COG1028@2|Bacteria,1MWB6@1224|Proteobacteria,42S4A@68525|delta/epsilon subdivisions,2WNE7@28221|Deltaproteobacteria,2Z3AJ@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.127	ko:K00065	ko00040,map00040	-	R01542	RC00089	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
HKD1_k127_148946_51	1382306.JNIM01000001_gene1463	7.836e-80	284.0	COG3875@1|root,COG3875@2|Bacteria,2G8B3@200795|Chloroflexi	200795|Chloroflexi	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_148946_16	234267.Acid_7084	3.822e-183	578.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria	57723|Acidobacteria	G	PfkB domain protein	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HKD1_k127_148946_68	485918.Cpin_5859	7.544e-52	190.0	COG4119@1|root,COG4119@2|Bacteria,4NRRR@976|Bacteroidetes,1ITJZ@117747|Sphingobacteriia	976|Bacteroidetes	L	pfam nudix	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_148946_36	1134912.AJTV01000021_gene3005	1.583e-109	366.0	COG0153@1|root,COG0153@2|Bacteria,1MVQD@1224|Proteobacteria,2U2RP@28211|Alphaproteobacteria,36ZV4@31993|Methylocystaceae	28211|Alphaproteobacteria	G	Galactokinase galactose-binding signature	galK	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HKD1_k127_148946_75	1267535.KB906767_gene1046	2.321e-37	153.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,OmpA,PD40
HKD1_k127_148946_31	234267.Acid_5939	4.943e-127	424.0	COG1807@1|root,COG1807@2|Bacteria,3Y383@57723|Acidobacteria	57723|Acidobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_148946_19	926549.KI421517_gene1084	3.553e-166	529.0	28JXC@1|root,2Z8EX@2|Bacteria,4NF7D@976|Bacteroidetes,47M9Z@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_148946_59	215803.DB30_0176	1.101e-63	227.0	COG1121@1|root,COG1121@2|Bacteria,1MUDW@1224|Proteobacteria,42UDG@68525|delta/epsilon subdivisions,2WQAB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD1_k127_148946_70	215803.DB30_0177	6.783e-46	176.0	COG1108@1|root,COG1108@2|Bacteria,1MVC2@1224|Proteobacteria,42U9W@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	ABC 3 transport family	-	-	-	ko:K09819,ko:K11606,ko:K11708,ko:K11709	ko02010,map02010	M00243,M00317,M00319	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15,3.A.1.15.7,3.A.1.15.9	-	-	ABC-3,Fe_dep_repr_C
HKD1_k127_148946_54	357808.RoseRS_1529	1.815e-77	276.0	COG0515@1|root,COG0515@2|Bacteria,2GACY@200795|Chloroflexi,375GK@32061|Chloroflexia	32061|Chloroflexia	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_148946_14	661478.OP10G_1529	5.62e-203	650.0	COG4805@1|root,COG4805@2|Bacteria	2|Bacteria	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_148946_86	1173020.Cha6605_3201	3.115e-15	83.0	COG2335@1|root,COG2335@2|Bacteria,1G5TY@1117|Cyanobacteria	1117|Cyanobacteria	M	PFAM Fasciclin domain	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_148946_85	304371.MCP_2884	1.079e-15	84.0	COG2335@1|root,arCOG03335@2157|Archaea,2XY3U@28890|Euryarchaeota,2NB0I@224756|Methanomicrobia	224756|Methanomicrobia	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_148946_34	1267535.KB906767_gene4240	1.08e-112	388.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HKD1_k127_148946_10	1340493.JNIF01000003_gene3527	1.29e-221	705.0	COG0441@1|root,COG0441@2|Bacteria,3Y2V0@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD1_k127_148946_62	641491.DND132_1096	6.742e-58	208.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,42RHA@68525|delta/epsilon subdivisions,2WNQW@28221|Deltaproteobacteria,2M933@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	GO:0003674,GO:0003676,GO:0003723,GO:0003743,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006412,GO:0006413,GO:0006518,GO:0006807,GO:0006996,GO:0008135,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016020,GO:0016043,GO:0019538,GO:0022411,GO:0032790,GO:0032984,GO:0032988,GO:0034641,GO:0034645,GO:0043021,GO:0043022,GO:0043043,GO:0043170,GO:0043603,GO:0043604,GO:0043933,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1903008	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD1_k127_148946_81	903818.KI912268_gene2462	1.616e-19	89.0	COG0291@1|root,COG0291@2|Bacteria,3Y5US@57723|Acidobacteria	57723|Acidobacteria	J	Ribosomal protein L35	-	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD1_k127_148946_71	240015.ACP_2248	1.823e-43	162.0	COG0292@1|root,COG0292@2|Bacteria,3Y4SW@57723|Acidobacteria,2JJJ2@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD1_k127_148946_35	397287.C807_01328	1.324e-109	366.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,27IWP@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Aminoacyl tRNA synthetase class II, N-terminal domain	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_148946_24	243231.GSU1520	2.381e-143	479.0	COG0072@1|root,COG0072@2|Bacteria,1MWKS@1224|Proteobacteria,42M1G@68525|delta/epsilon subdivisions,2WJ7V@28221|Deltaproteobacteria,43TCH@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	TIGRFAM phenylalanyl-tRNA synthetase, beta subunit	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006432,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009328,GO:0009987,GO:0010467,GO:0016070,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD1_k127_148946_91	1087481.AGFX01000041_gene864	1.661e-06	55.0	COG3027@1|root,COG3027@2|Bacteria,1VFZR@1239|Firmicutes,4HNRI@91061|Bacilli,26QBQ@186822|Paenibacillaceae	91061|Bacilli	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD1_k127_148946_47	485916.Dtox_3099	1.118e-80	276.0	COG1692@1|root,COG1692@2|Bacteria,1TR9P@1239|Firmicutes,24967@186801|Clostridia,2604A@186807|Peptococcaceae	186801|Clostridia	S	TIGRFAM metallophosphoesterase, MG_246 BB_0505 family	-	-	-	ko:K09769	-	-	-	-	ko00000	-	-	-	YmdB
HKD1_k127_148946_73	1267533.KB906733_gene3589	1.708e-38	149.0	COG0824@1|root,COG0824@2|Bacteria,3Y4WZ@57723|Acidobacteria,2JJIE@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM thioesterase superfamily	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD1_k127_148946_67	502025.Hoch_4877	7.133e-53	204.0	COG2856@1|root,COG2856@2|Bacteria,1PADA@1224|Proteobacteria,434WD@68525|delta/epsilon subdivisions,2WZ7C@28221|Deltaproteobacteria,2Z1HG@29|Myxococcales	28221|Deltaproteobacteria	E	Zn peptidase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_148946_7	861299.J421_3346	1.53e-230	726.0	COG4799@1|root,COG4799@2|Bacteria,1ZTGB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	Carboxyl transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD1_k127_148946_12	379066.GAU_1706	7.762e-208	654.0	COG3185@1|root,COG3185@2|Bacteria,1ZT5D@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
HKD1_k127_148946_72	861299.J421_3344	7.006e-43	159.0	2CIU6@1|root,32S8H@2|Bacteria,1ZTUM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_148946_55	797209.ZOD2009_19858	1.16e-75	264.0	COG0596@1|root,arCOG01648@2157|Archaea,2XSWV@28890|Euryarchaeota,23T2R@183963|Halobacteria	183963|Halobacteria	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	yfhM	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_148946_61	1189612.A33Q_2090	9.956e-59	212.0	COG1024@1|root,COG1024@2|Bacteria,4NI32@976|Bacteroidetes,47MCZ@768503|Cytophagia	976|Bacteroidetes	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.18	ko:K13766	ko00280,ko01100,map00280,map01100	M00036	R02085	RC02416	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_148946_64	290397.Adeh_1832	2.131e-55	196.0	COG2185@1|root,COG2185@2|Bacteria,1RKGS@1224|Proteobacteria,42SKV@68525|delta/epsilon subdivisions,2WP2X@28221|Deltaproteobacteria,2YV7A@29|Myxococcales	28221|Deltaproteobacteria	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD1_k127_148946_8	204669.Acid345_1454	1.344e-225	711.0	COG1884@1|root,COG1884@2|Bacteria,3Y2PQ@57723|Acidobacteria,2JHJN@204432|Acidobacteriia	204432|Acidobacteriia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD1_k127_148946_0	1382359.JIAL01000001_gene12	0.0	1004.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_148946_84	682795.AciX8_4485	8.983e-16	78.0	COG0828@1|root,COG0828@2|Bacteria,3Y5J9@57723|Acidobacteria,2JJWG@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_148946_58	1232410.KI421413_gene669	3.12e-69	244.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,42N0I@68525|delta/epsilon subdivisions,2WMUX@28221|Deltaproteobacteria,43T33@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD1_k127_148946_60	269799.Gmet_1420	5.743e-60	214.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,42QSI@68525|delta/epsilon subdivisions,2WMNJ@28221|Deltaproteobacteria,43TVI@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins	pcm	GO:0003674,GO:0003824,GO:0004719,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006464,GO:0006479,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0009987,GO:0010340,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0036211,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044464,GO:0051998,GO:0071704,GO:0140096,GO:1901564	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD1_k127_148946_42	1123368.AUIS01000004_gene227	6.346e-88	295.0	COG0586@1|root,COG0586@2|Bacteria,1RGII@1224|Proteobacteria,1S844@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	SNARE associated Golgi protein	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	SNARE_assoc
HKD1_k127_148946_90	1267535.KB906767_gene1605	1.045e-06	50.0	COG4941@1|root,COG4941@2|Bacteria,3Y2V5@57723|Acidobacteria,2JKS8@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_148946_30	661478.OP10G_1219	8.947e-130	420.0	COG0596@1|root,COG0596@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_148946_93	1123248.KB893324_gene1707	3.241e-05	48.0	COG0457@1|root,COG0457@2|Bacteria,4PN62@976|Bacteroidetes,1IQEB@117747|Sphingobacteriia	976|Bacteroidetes	S	Rifampin ADP-ribosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Arr-ms
HKD1_k127_148946_37	756272.Plabr_4599	2.26e-108	368.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,CBM_6,DUF4955,F5_F8_type_C,Pectate_lyase_3
HKD1_k127_148946_15	204669.Acid345_1052	1.877e-185	608.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_148946_78	573370.DMR_08370	8.974e-24	115.0	COG2706@1|root,COG2706@2|Bacteria,1QYRS@1224|Proteobacteria,43D4J@68525|delta/epsilon subdivisions,2WUZF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_148946_33	1121920.AUAU01000005_gene1038	7.777e-116	390.0	COG1228@1|root,COG1228@2|Bacteria,3Y4IP@57723|Acidobacteria	57723|Acidobacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_148946_77	1379698.RBG1_1C00001G1887	2.98e-32	135.0	COG1514@1|root,COG1514@2|Bacteria,2NPRT@2323|unclassified Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0008104,GO:0008150,GO:0009966,GO:0010646,GO:0010738,GO:0023051,GO:0033036,GO:0034237,GO:0044424,GO:0044444,GO:0044464,GO:0048583,GO:0050789,GO:0050794,GO:0051018,GO:0051179,GO:0065007,GO:1902531	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD1_k127_148946_25	997346.HMPREF9374_0758	4.987e-143	483.0	COG2366@1|root,COG2366@2|Bacteria,1UFHA@1239|Firmicutes,4HACM@91061|Bacilli,27CTF@186824|Thermoactinomycetaceae	91061|Bacilli	S	Penicillin amidase	acyII	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD1_k127_148946_89	1125863.JAFN01000001_gene1668	5.507e-10	70.0	2ER9F@1|root,33IV2@2|Bacteria,1P4XJ@1224|Proteobacteria,433CC@68525|delta/epsilon subdivisions,2WXNX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_148946_82	204669.Acid345_4653	2.625e-18	94.0	COG1238@1|root,COG1238@2|Bacteria,3Y52F@57723|Acidobacteria,2JJK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_148946_79	1340493.JNIF01000004_gene241	1.5e-22	105.0	COG1238@1|root,COG1238@2|Bacteria,3Y52F@57723|Acidobacteria	57723|Acidobacteria	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_148946_74	518766.Rmar_1242	2.922e-38	154.0	COG0322@1|root,COG0847@1|root,COG0322@2|Bacteria,COG0847@2|Bacteria,4NEQX@976|Bacteroidetes	976|Bacteroidetes	L	DNA polymerase III	-	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	GIY-YIG,RNase_T
HKD1_k127_148946_65	234267.Acid_4993	3.085e-53	194.0	COG0461@1|root,COG0461@2|Bacteria	2|Bacteria	F	orotate phosphoribosyltransferase activity	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_148946_63	240015.ACP_0688	1.463e-55	203.0	COG0101@1|root,COG0101@2|Bacteria,3Y2MS@57723|Acidobacteria,2JIWS@204432|Acidobacteriia	204432|Acidobacteriia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD1_k127_148946_50	760568.Desku_2556	6.36e-80	274.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,260D7@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_148946_76	1499967.BAYZ01000078_gene990	1.951e-36	149.0	COG4589@1|root,COG4589@2|Bacteria,2NPVB@2323|unclassified Bacteria	2|Bacteria	S	Belongs to the CDS family	cdsA	GO:0003674,GO:0003824,GO:0004605,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006220,GO:0006221,GO:0006629,GO:0006644,GO:0006650,GO:0006655,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009117,GO:0009165,GO:0009987,GO:0016020,GO:0016024,GO:0016740,GO:0016772,GO:0016779,GO:0018130,GO:0019438,GO:0019637,GO:0030312,GO:0034641,GO:0034654,GO:0040007,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044271,GO:0044281,GO:0044464,GO:0045017,GO:0046341,GO:0046471,GO:0046474,GO:0046483,GO:0046486,GO:0055086,GO:0070567,GO:0071704,GO:0071944,GO:0072527,GO:0072528,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS06255	CTP_transf_1
HKD1_k127_148946_88	867900.Celly_3047	4.187e-11	68.0	COG1714@1|root,COG1714@2|Bacteria,4NN48@976|Bacteroidetes,1I1AH@117743|Flavobacteriia	976|Bacteroidetes	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	Coa1,RDD
HKD1_k127_148946_32	1157490.EL26_12795	9.734e-120	396.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,4HBAV@91061|Bacilli,2788P@186823|Alicyclobacillaceae	91061|Bacilli	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD1_k127_148946_53	204669.Acid345_1420	5.04e-79	281.0	COG0750@1|root,COG0750@2|Bacteria,3Y2KN@57723|Acidobacteria,2JI1B@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidase family M50	-	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_M50
HKD1_k127_148946_29	1121468.AUBR01000029_gene1577	1.287e-130	426.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,247N1@186801|Clostridia,42FDK@68295|Thermoanaerobacterales	186801|Clostridia	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06430	GcpE
HKD1_k127_148946_69	338963.Pcar_1692	1.432e-51	196.0	COG2812@1|root,COG2812@2|Bacteria,1QVB3@1224|Proteobacteria,42SBC@68525|delta/epsilon subdivisions,2WPCK@28221|Deltaproteobacteria,43RXK@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	DNA polymerase III, delta subunit, C terminal	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD1_k127_148946_66	351607.Acel_1971	3.647e-53	196.0	COG0125@1|root,COG0477@1|root,COG0125@2|Bacteria,COG2814@2|Bacteria,2GNTI@201174|Actinobacteria,4ES48@85013|Frankiales	201174|Actinobacteria	EFGP	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	MFS_3,Thymidylate_kin
HKD1_k127_148946_80	401053.AciPR4_3269	1.372e-19	94.0	COG1923@1|root,COG1923@2|Bacteria,3Y59T@57723|Acidobacteria,2JJSQ@204432|Acidobacteriia	204432|Acidobacteriia	S	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD1_k127_148946_57	234267.Acid_1297	6.762e-72	254.0	COG0324@1|root,COG0324@2|Bacteria,3Y3CE@57723|Acidobacteria	57723|Acidobacteria	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD1_k127_1567212_38	926566.Terro_1500	6.364e-09	66.0	COG2885@1|root,COG2885@2|Bacteria,3Y310@57723|Acidobacteria,2JI18@204432|Acidobacteriia	204432|Acidobacteriia	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_1567212_37	1267534.KB906755_gene3915	1.062e-09	68.0	2DPEJ@1|root,331S0@2|Bacteria,3Y4CR@57723|Acidobacteria,2JP6H@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_2	1267535.KB906767_gene4766	1.592e-213	682.0	COG1964@1|root,COG1964@2|Bacteria,3Y2WC@57723|Acidobacteria,2JHTH@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_1567212_32	929562.Emtol_3287	4.632e-23	112.0	2AUD4@1|root,31K11@2|Bacteria	2|Bacteria	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD1_k127_1567212_16	1267535.KB906767_gene4415	8.044e-86	296.0	COG1044@1|root,COG1044@2|Bacteria,3Y6ZT@57723|Acidobacteria	57723|Acidobacteria	M	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD	-	-	2.3.1.191	ko:K02536	ko00540,ko01100,map00540,map01100	M00060	R04550	RC00039,RC00166	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hexapep,LpxD
HKD1_k127_1567212_36	671143.DAMO_0870	1.765e-11	76.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	ko:K03194	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	CHAP,SLT
HKD1_k127_1567212_22	234267.Acid_5050	3.414e-54	206.0	COG0612@1|root,COG0612@2|Bacteria	2|Bacteria	L	Peptidase, M16	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Big_2,F5_F8_type_C,Glyco_hydro_98C,Glyco_hydro_98M,NPCBM,Peptidase_M16,Peptidase_M16_C
HKD1_k127_1567212_40	234267.Acid_2313	3.706e-07	56.0	2EVWN@1|root,33PAB@2|Bacteria,3Y5UR@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_19	335543.Sfum_0112	1.395e-75	261.0	COG1028@1|root,COG1028@2|Bacteria,1MWJI@1224|Proteobacteria,42SJ9@68525|delta/epsilon subdivisions,2WPBC@28221|Deltaproteobacteria,2MRQE@213462|Syntrophobacterales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_1567212_25	311424.DhcVS_587	2.782e-39	152.0	COG1611@1|root,COG1611@2|Bacteria,2G9EJ@200795|Chloroflexi,34DB6@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Belongs to the LOG family	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	-
HKD1_k127_1567212_13	589865.DaAHT2_0467	1.61e-102	349.0	COG0477@1|root,COG2814@2|Bacteria,1QW2F@1224|Proteobacteria,43BTU@68525|delta/epsilon subdivisions,2X74Q@28221|Deltaproteobacteria,2MKZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD1_k127_1567212_10	1198114.AciX9_2892	1.308e-119	411.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HKD1_k127_1567212_34	1120999.JONM01000007_gene1751	4.612e-20	106.0	COG0642@1|root,COG2199@1|root,COG4251@1|root,COG2205@2|Bacteria,COG3706@2|Bacteria,COG4251@2|Bacteria,1NRP8@1224|Proteobacteria,2VJI1@28216|Betaproteobacteria	28216|Betaproteobacteria	T	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD1_k127_1567212_17	379066.GAU_2015	1.173e-83	303.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1ZTDZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4
HKD1_k127_1567212_7	379066.GAU_2014	1.94e-126	419.0	COG2204@1|root,COG2204@2|Bacteria,1ZUM4@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1567212_4	767817.Desgi_1433	2.139e-162	527.0	COG0365@1|root,COG0365@2|Bacteria,1UMN9@1239|Firmicutes,25GME@186801|Clostridia	186801|Clostridia	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_1567212_20	1117647.M5M_17215	5.106e-60	218.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,1RXYM@1236|Gammaproteobacteria,1JAQ6@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006084,GO:0006139,GO:0006163,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006637,GO:0006725,GO:0006732,GO:0006753,GO:0006790,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009117,GO:0009150,GO:0009259,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019442,GO:0019637,GO:0019693,GO:0019752,GO:0020037,GO:0022607,GO:0033865,GO:0033875,GO:0034032,GO:0034641,GO:0035383,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043603,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051186,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055086,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0072521,GO:0097159,GO:1901135,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD1_k127_1567212_31	926549.KI421517_gene1149	6.964e-25	111.0	297E6@1|root,2ZUMN@2|Bacteria,4NPTI@976|Bacteroidetes,47R84@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_1567212_6	234267.Acid_2875	4.708e-140	455.0	COG3844@1|root,COG3844@2|Bacteria,3Y984@57723|Acidobacteria	57723|Acidobacteria	F	Aminotransferase class-V	-	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD1_k127_1567212_3	502025.Hoch_0175	3.247e-210	663.0	COG1902@1|root,COG1902@2|Bacteria,1R4A8@1224|Proteobacteria,42YBR@68525|delta/epsilon subdivisions,2WU33@28221|Deltaproteobacteria,2YXDW@29|Myxococcales	28221|Deltaproteobacteria	C	NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD1_k127_1567212_30	1004785.AMBLS11_10285	3.237e-31	128.0	2E363@1|root,32Y5Y@2|Bacteria,1P1I8@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_15	234267.Acid_5478	1.539e-86	306.0	COG0642@1|root,COG2205@2|Bacteria,3Y8HM@57723|Acidobacteria	57723|Acidobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_1567212_24	234267.Acid_2286	2.623e-42	166.0	COG0671@1|root,COG0671@2|Bacteria,3Y5F0@57723|Acidobacteria	57723|Acidobacteria	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD1_k127_1567212_12	682795.AciX8_3593	7.124e-112	372.0	COG3391@1|root,COG3391@2|Bacteria,3Y48Y@57723|Acidobacteria,2JJ87@204432|Acidobacteriia	204432|Acidobacteriia	S	YVTN family beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_1	1267533.KB906741_gene557	1.627e-287	916.0	COG0841@1|root,COG0841@2|Bacteria,3Y3F4@57723|Acidobacteria,2JIHS@204432|Acidobacteriia	204432|Acidobacteriia	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_1567212_23	278963.ATWD01000001_gene4605	1.428e-45	181.0	COG0845@1|root,COG0845@2|Bacteria,3Y3C9@57723|Acidobacteria,2JIN9@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_1567212_29	1267535.KB906767_gene5350	4.432e-32	141.0	COG1538@1|root,COG1538@2|Bacteria,3Y3PX@57723|Acidobacteria,2JHUZ@204432|Acidobacteriia	204432|Acidobacteriia	MU	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_1567212_18	234267.Acid_5477	4.021e-83	282.0	COG0745@1|root,COG0745@2|Bacteria,3Y522@57723|Acidobacteria	57723|Acidobacteria	K	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_1567212_9	1379698.RBG1_1C00001G0370	5.741e-122	413.0	COG0616@1|root,COG0616@2|Bacteria,2NNKU@2323|unclassified Bacteria	2|Bacteria	OU	Peptidase family S49	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD1_k127_1567212_39	643473.KB235930_gene1727	1.11e-08	69.0	COG2133@1|root,COG2373@1|root,COG2931@1|root,COG2133@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,1G2CB@1117|Cyanobacteria,1HRM4@1161|Nostocales	1117|Cyanobacteria	G	PA14	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,GSDH,Lectin_C,PA14
HKD1_k127_1567212_21	118163.Ple7327_0239	9.57e-59	233.0	COG2931@1|root,COG2931@2|Bacteria,1GB2M@1117|Cyanobacteria	1117|Cyanobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_42	886293.Sinac_6304	9.82e-05	56.0	COG3291@1|root,COG3420@1|root,COG3291@2|Bacteria,COG3420@2|Bacteria,2J2YS@203682|Planctomycetes	203682|Planctomycetes	P	antibiotic catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_8	639030.JHVA01000001_gene1462	2.594e-125	411.0	COG0482@1|root,COG0482@2|Bacteria,3Y2JX@57723|Acidobacteria,2JHKV@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_1567212_26	1192034.CAP_4647	3.076e-34	139.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.180	ko:K18846	-	-	-	-	ko00000,ko01000,ko01504,ko03009	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_1567212_11	192952.MM_2988	6.044e-115	376.0	COG0714@1|root,arCOG00441@2157|Archaea,2Y6X0@28890|Euryarchaeota,2NAEY@224756|Methanomicrobia	224756|Methanomicrobia	S	CbbQ/NirQ/NorQ C-terminal	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5,CbbQ_C
HKD1_k127_1567212_14	330214.NIDE3564	2.795e-88	328.0	COG4548@1|root,COG4548@2|Bacteria	2|Bacteria	P	von Willebrand factor (vWF) type A domain	-	-	-	ko:K02448	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	VWA,VWA_2
HKD1_k127_1567212_28	204669.Acid345_4762	9.749e-33	144.0	28N30@1|root,2ZB8S@2|Bacteria,3Y2XH@57723|Acidobacteria,2JI3V@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1567212_5	1379698.RBG1_1C00001G0804	2.032e-147	478.0	COG0183@1|root,COG0183@2|Bacteria,2NNU9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_1567212_27	517418.Ctha_0624	5.653e-34	137.0	COG1225@1|root,COG1225@2|Bacteria,1FF59@1090|Chlorobi	1090|Chlorobi	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_1567212_33	379066.GAU_0167	3.301e-22	98.0	COG2924@1|root,COG2924@2|Bacteria,1ZTWZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HKD1_k127_1567212_0	575540.Isop_3282	0.0	1212.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2IX33@203682|Planctomycetes	203682|Planctomycetes	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_1580709_20	1267535.KB906767_gene2093	3.162e-109	365.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_3
HKD1_k127_1580709_2	1267535.KB906767_gene2094	2.823e-267	839.0	COG1131@1|root,COG1131@2|Bacteria,3Y3VU@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1580709_15	1267535.KB906767_gene2095	6.357e-131	428.0	COG1566@1|root,COG1566@2|Bacteria	2|Bacteria	V	PFAM secretion protein HlyD family protein	yhiI	-	-	ko:K01993,ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_1580709_27	234267.Acid_2365	1.72e-85	307.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HKD1_k127_1580709_0	234267.Acid_2365	0.0	1280.0	COG0841@1|root,COG1538@1|root,COG0841@2|Bacteria,COG1538@2|Bacteria,3Y6DS@57723|Acidobacteria	57723|Acidobacteria	V	AcrB/AcrD/AcrF family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran,OEP
HKD1_k127_1580709_41	1192034.CAP_7194	4.791e-53	206.0	COG0845@1|root,COG0845@2|Bacteria,1MX0G@1224|Proteobacteria,42RBE@68525|delta/epsilon subdivisions,2WN7J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_1580709_47	671143.DAMO_1259	5.7e-42	164.0	COG1309@1|root,COG1309@2|Bacteria,2NQ8G@2323|unclassified Bacteria	2|Bacteria	K	Bacterial regulatory proteins, tetR family	MA20_16815	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_1580709_53	1237149.C900_00073	1.437e-35	145.0	COG0457@1|root,COG0457@2|Bacteria	1237149.C900_00073|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_72	1038860.AXAP01000029_gene680	1.352e-09	61.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,3JWJS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Transketolase, pyrimidine binding domain	tkt	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD1_k127_1580709_19	700598.Niako_7228	2.315e-113	377.0	COG0673@1|root,COG0673@2|Bacteria,4NE75@976|Bacteroidetes,1IPB6@117747|Sphingobacteriia	976|Bacteroidetes	S	Glucose--fructose oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_1580709_44	1210884.HG799463_gene9685	2.487e-48	179.0	2ESSA@1|root,33KAQ@2|Bacteria,2J1KK@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_71	1303518.CCALI_00998	4.379e-10	64.0	COG2308@1|root,COG2308@2|Bacteria	2|Bacteria	S	glutamate-cysteine ligase activity	gcs2	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_1,CP_ATPgrasp_2
HKD1_k127_1580709_11	240015.ACP_0866	2.826e-165	532.0	COG3669@1|root,COG3669@2|Bacteria,3Y43P@57723|Acidobacteria,2JJ93@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, family 29	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos
HKD1_k127_1580709_7	1267535.KB906767_gene1897	5.581e-210	664.0	COG0627@1|root,COG0627@2|Bacteria	2|Bacteria	J	Serine hydrolase involved in the detoxification of formaldehyde	-	-	3.1.1.102	ko:K21105	-	-	R11541	RC00020,RC00041	ko00000,ko01000	-	-	-	Esterase,Tannase
HKD1_k127_1580709_74	234267.Acid_3371	2.482e-07	55.0	COG0265@1|root,COG0265@2|Bacteria,3Y2WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_1580709_55	1157490.EL26_16705	2.124e-33	136.0	COG2320@1|root,COG2320@2|Bacteria,1V3IB@1239|Firmicutes,4HKXN@91061|Bacilli,27A9D@186823|Alicyclobacillaceae	91061|Bacilli	S	GrpB protein	yqkA1	-	-	-	-	-	-	-	-	-	-	-	GrpB
HKD1_k127_1580709_58	113395.AXAI01000006_gene1736	1.728e-27	127.0	COG1917@1|root,COG1917@2|Bacteria,1RB5Y@1224|Proteobacteria,2U5TF@28211|Alphaproteobacteria,3JY68@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_28	543728.Vapar_5788	3.946e-79	282.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2VTEZ@28216|Betaproteobacteria,4AI6U@80864|Comamonadaceae	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD1_k127_1580709_64	1121899.Q764_04805	8.007e-22	102.0	COG3548@1|root,COG3548@2|Bacteria,4NPIF@976|Bacteroidetes,1I1Y3@117743|Flavobacteriia,2NU69@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD1_k127_1580709_77	1120950.KB892720_gene1858	1.973e-06	53.0	COG3548@1|root,COG3548@2|Bacteria,2IGXY@201174|Actinobacteria,4DUV8@85009|Propionibacteriales	201174|Actinobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD1_k127_1580709_18	1267535.KB906767_gene3762	9.071e-121	394.0	COG1595@1|root,COG1595@2|Bacteria,3Y5BP@57723|Acidobacteria,2JM56@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2,SnoaL_2
HKD1_k127_1580709_21	1267535.KB906767_gene3760	2.72e-106	351.0	COG0702@1|root,COG0702@2|Bacteria,3Y3QX@57723|Acidobacteria,2JJ6V@204432|Acidobacteriia	204432|Acidobacteriia	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD1_k127_1580709_12	1042326.AZNV01000003_gene3997	1.039e-152	488.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,2TRUA@28211|Alphaproteobacteria,4B8Q9@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_1580709_25	1163408.UU9_05879	4.828e-95	316.0	COG1418@1|root,COG1418@2|Bacteria,1MV0J@1224|Proteobacteria,1S5E6@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_1580709_43	944435.AXAJ01000011_gene3063	4.606e-52	188.0	COG1917@1|root,COG1917@2|Bacteria,1RH8X@1224|Proteobacteria,2VSGV@28216|Betaproteobacteria,1K8VS@119060|Burkholderiaceae	28216|Betaproteobacteria	S	PFAM Cupin 2 conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_1580709_22	1449076.JOOE01000001_gene2448	2.365e-102	340.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria,2VFDU@28211|Alphaproteobacteria,2K48Y@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD1_k127_1580709_50	485913.Krac_5622	4.387e-38	145.0	COG5207@1|root,COG5207@2|Bacteria	2|Bacteria	O	Pfam Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N,zf-UBP
HKD1_k127_1580709_57	1047013.AQSP01000139_gene2414	3.632e-31	134.0	COG0457@1|root,COG0457@2|Bacteria,2NRWN@2323|unclassified Bacteria	2|Bacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_56	1121859.KB890750_gene273	2.653e-31	143.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	Alpha_L_fucos,CARDB,CHU_C,Calx-beta,DUF4091,F5_F8_type_C,G5,Gram_pos_anchor,PPC,Trypsin_2,YSIRK_signal
HKD1_k127_1580709_9	1304275.C41B8_18181	4.119e-191	611.0	COG0437@1|root,COG3301@1|root,COG0437@2|Bacteria,COG3301@2|Bacteria,1MU1B@1224|Proteobacteria,1SYJH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_11,Fer4_3,Fer4_7
HKD1_k127_1580709_13	204669.Acid345_0704	4.534e-145	469.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_1580709_30	555079.Toce_0103	8.912e-73	254.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,42FE4@68295|Thermoanaerobacterales	186801|Clostridia	S	TIGRFAM MazG family protein	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
HKD1_k127_1580709_68	439235.Dalk_3378	5.819e-15	81.0	2EAFJ@1|root,334IY@2|Bacteria,1NA2Y@1224|Proteobacteria,42VJ1@68525|delta/epsilon subdivisions,2WRKE@28221|Deltaproteobacteria,2MKY4@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1844)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1844
HKD1_k127_1580709_31	204669.Acid345_2630	4.397e-70	245.0	COG1235@1|root,COG1235@2|Bacteria,3Y40S@57723|Acidobacteria,2JIH7@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HKD1_k127_1580709_32	1340493.JNIF01000004_gene549	4.629e-67	239.0	COG0196@1|root,COG1235@1|root,COG0196@2|Bacteria,COG1235@2|Bacteria,3Y34N@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the ribF family	-	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_1580709_49	575540.Isop_3374	5.926e-40	154.0	COG1743@1|root,COG1943@1|root,COG1743@2|Bacteria,COG1943@2|Bacteria,2J099@203682|Planctomycetes	203682|Planctomycetes	L	Transposase IS200 like	-	-	-	ko:K07445	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_1580709_10	1304872.JAGC01000009_gene46	5.496e-174	570.0	COG0330@1|root,COG0330@2|Bacteria,1MW1D@1224|Proteobacteria,42PKQ@68525|delta/epsilon subdivisions,2WM5Y@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	SPFH domain / Band 7 family	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_1580709_6	861299.J421_1696	4.385e-212	686.0	COG2866@1|root,COG2866@2|Bacteria,1ZUNB@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD1_k127_1580709_54	720554.Clocl_2931	2.159e-34	148.0	COG2865@1|root,COG2865@2|Bacteria,1TSPK@1239|Firmicutes,249QT@186801|Clostridia,3WMNT@541000|Ruminococcaceae	186801|Clostridia	K	Putative ATP-dependent DNA helicase recG C-terminal	-	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AlbA_2,HATPase_c_4
HKD1_k127_1580709_51	498848.TaqDRAFT_4855	7.515e-36	142.0	COG0801@1|root,COG0801@2|Bacteria,1WJU9@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	H	TIGRFAM 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD1_k127_1580709_5	861299.J421_1510	2.463e-213	675.0	COG0154@1|root,COG0154@2|Bacteria,1ZT8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	J	Amidase	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD1_k127_1580709_26	1121920.AUAU01000007_gene408	1.121e-93	332.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD1_k127_1580709_38	682795.AciX8_4233	1.4e-55	205.0	COG1215@1|root,COG1215@2|Bacteria,3Y3PN@57723|Acidobacteria,2JHSE@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_1580709_29	321332.CYB_0455	9.648e-74	255.0	COG0854@1|root,COG0854@2|Bacteria,1G0QW@1117|Cyanobacteria,1GZKF@1129|Synechococcus	1117|Cyanobacteria	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008614,GO:0008615,GO:0009058,GO:0009110,GO:0009987,GO:0016740,GO:0016769,GO:0017144,GO:0018130,GO:0019438,GO:0033856,GO:0034641,GO:0042364,GO:0042816,GO:0042819,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:0072524,GO:0072525,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901615,GO:1901617	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD1_k127_1580709_60	883.DvMF_2832	1.013e-24	108.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,42TII@68525|delta/epsilon subdivisions,2WPVK@28221|Deltaproteobacteria,2MBW9@213115|Desulfovibrionales	28221|Deltaproteobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016469,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0032991,GO:0033178,GO:0034220,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044464,GO:0045259,GO:0045261,GO:0046034,GO:0046390,GO:0046483,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD1_k127_1580709_4	1382359.JIAL01000001_gene2069	1.978e-231	725.0	COG0055@1|root,COG0055@2|Bacteria,3Y2PU@57723|Acidobacteria,2JIDM@204432|Acidobacteriia	204432|Acidobacteriia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_1580709_62	999419.HMPREF1077_01429	2.641e-23	103.0	COG1725@1|root,COG1725@2|Bacteria,4PKHR@976|Bacteroidetes,2G09Z@200643|Bacteroidia,2313V@171551|Porphyromonadaceae	976|Bacteroidetes	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	-	-	-	-	-	-	-	-	-	GntR,Peripla_BP_3
HKD1_k127_1580709_23	646529.Desaci_3047	7.019e-102	340.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia	186801|Clostridia	O	SPFH Band 7 PHB domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD1_k127_1580709_78	240015.ACP_1895	2.94e-06	52.0	2EE2F@1|root,337X5@2|Bacteria,3Y5GQ@57723|Acidobacteria,2JJT5@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_3	926569.ANT_02690	3.486e-233	732.0	COG1884@1|root,COG1884@2|Bacteria,2G5TP@200795|Chloroflexi	200795|Chloroflexi	I	TIGRFAM methylmalonyl-CoA mutase, large subunit	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HKD1_k127_1580709_69	13616.ENSMODP00000013659	9.47e-14	84.0	COG0457@1|root,KOG1126@2759|Eukaryota,38DG8@33154|Opisthokonta,3BENB@33208|Metazoa,3CWDT@33213|Bilateria,482HE@7711|Chordata,491M1@7742|Vertebrata,3J5GW@40674|Mammalia,4JXF3@9263|Metatheria	33208|Metazoa	D	Cell division cycle 27	CDC27	GO:0000003,GO:0000151,GO:0000152,GO:0000209,GO:0000278,GO:0000375,GO:0000377,GO:0000398,GO:0001775,GO:0003002,GO:0003674,GO:0003824,GO:0004842,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005680,GO:0005737,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0006139,GO:0006396,GO:0006397,GO:0006464,GO:0006508,GO:0006511,GO:0006725,GO:0006807,GO:0006810,GO:0006887,GO:0007049,GO:0007088,GO:0007091,GO:0007275,GO:0007338,GO:0007343,GO:0007346,GO:0007389,GO:0008150,GO:0008152,GO:0008283,GO:0008356,GO:0008380,GO:0009056,GO:0009057,GO:0009566,GO:0009798,GO:0009948,GO:0009949,GO:0009952,GO:0009987,GO:0010467,GO:0010498,GO:0010564,GO:0010965,GO:0015630,GO:0016070,GO:0016071,GO:0016192,GO:0016567,GO:0016740,GO:0017156,GO:0019538,GO:0019787,GO:0019899,GO:0019902,GO:0019903,GO:0019941,GO:0019953,GO:0022402,GO:0022414,GO:0030163,GO:0031145,GO:0031461,GO:0031974,GO:0031981,GO:0032446,GO:0032501,GO:0032502,GO:0032940,GO:0032991,GO:0033043,GO:0033044,GO:0033045,GO:0033047,GO:0034641,GO:0036211,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043632,GO:0043900,GO:0043901,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044464,GO:0044703,GO:0044770,GO:0044772,GO:0044784,GO:0045055,GO:0046483,GO:0046903,GO:0048519,GO:0048856,GO:0050789,GO:0050794,GO:0051128,GO:0051179,GO:0051234,GO:0051301,GO:0051603,GO:0051704,GO:0051726,GO:0051783,GO:0051983,GO:0060467,GO:0060468,GO:0060471,GO:0061630,GO:0061659,GO:0065001,GO:0065007,GO:0070013,GO:0070647,GO:0070979,GO:0071704,GO:0080154,GO:0090304,GO:0140096,GO:1901360,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1903047,GO:1905818,GO:1990234,GO:2000241,GO:2000242	-	ko:K03350	ko04110,ko04111,ko04113,ko04114,ko04120,ko04914,ko05166,map04110,map04111,map04113,map04114,map04120,map04914,map05166	M00389	-	-	ko00000,ko00001,ko00002,ko01009,ko03036,ko04121	-	-	-	ANAPC3,TPR_1,TPR_16,TPR_6,TPR_8
HKD1_k127_1580709_52	203122.Sde_0642	1.349e-35	143.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	NACHT
HKD1_k127_1580709_59	998088.B565_3616	3.634e-26	112.0	COG0454@1|root,COG0456@2|Bacteria,1N6QA@1224|Proteobacteria,1SDXW@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD1_k127_1580709_76	338966.Ppro_2456	8.44e-07	62.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DUF3488,DUF4129,Transglut_core
HKD1_k127_1580709_14	1267534.KB906757_gene882	8.457e-145	465.0	COG4977@1|root,COG4977@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	AraC_binding,Cupin_6,HTH_18
HKD1_k127_1580709_63	1304865.JAGF01000001_gene4019	2.82e-22	98.0	COG1942@1|root,COG1942@2|Bacteria	2|Bacteria	S	isomerase activity	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_1580709_37	1267534.KB906757_gene883	2.463e-58	209.0	2EHG8@1|root,33B84@2|Bacteria,3Y808@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_75	568706.BN118_2122	4.516e-07	59.0	COG2823@1|root,COG2823@2|Bacteria,1NIM8@1224|Proteobacteria,2WG5J@28216|Betaproteobacteria,3T7XW@506|Alcaligenaceae	28216|Betaproteobacteria	S	periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_1580709_80	1121106.JQKB01000057_gene612	2.999e-05	51.0	COG3237@1|root,COG3237@2|Bacteria,1NGW6@1224|Proteobacteria,2UJAV@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Belongs to the UPF0337 (CsbD) family	-	-	-	-	-	-	-	-	-	-	-	-	CsbD
HKD1_k127_1580709_70	1246626.BleG1_3504	1.418e-11	70.0	2EFZF@1|root,339RM@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1580709_35	1267533.KB906735_gene4526	3.613e-59	217.0	COG1295@1|root,COG1295@2|Bacteria,3Y3RZ@57723|Acidobacteria,2JIYV@204432|Acidobacteriia	204432|Acidobacteriia	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_1580709_46	517417.Cpar_1547	8.115e-44	173.0	COG0681@1|root,COG0681@2|Bacteria,1FDIZ@1090|Chlorobi	1090|Chlorobi	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24,Peptidase_S26
HKD1_k127_1580709_45	330214.NIDE0800	4.806e-45	172.0	COG0571@1|root,COG0571@2|Bacteria,3J119@40117|Nitrospirae	40117|Nitrospirae	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	-	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD1_k127_1580709_40	204669.Acid345_3450	2.065e-53	209.0	COG0768@1|root,COG0768@2|Bacteria,3Y3EP@57723|Acidobacteria,2JI45@204432|Acidobacteriia	204432|Acidobacteriia	M	penicillin-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	Transpeptidase
HKD1_k127_1580709_34	671143.DAMO_2838	2.282e-61	231.0	COG4191@1|root,COG4191@2|Bacteria,2NQ9P@2323|unclassified Bacteria	2|Bacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1580709_16	1499967.BAYZ01000195_gene3085	9.597e-127	420.0	COG2204@1|root,COG2204@2|Bacteria,2NNPN@2323|unclassified Bacteria	2|Bacteria	T	COGs COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_1580709_61	1294265.JCM21738_4707	7.391e-24	113.0	COG3206@1|root,COG3206@2|Bacteria,1V8AX@1239|Firmicutes,4HCT2@91061|Bacilli,1ZDP1@1386|Bacillus	91061|Bacilli	M	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349
HKD1_k127_1580709_66	1121930.AQXG01000008_gene137	1.842e-21	100.0	COG4232@1|root,COG4232@2|Bacteria,4NEW6@976|Bacteroidetes	976|Bacteroidetes	CO	Cytochrome c biogenesis protein transmembrane region	-	-	1.8.1.8	ko:K04084	-	-	-	-	ko00000,ko01000,ko03110	5.A.1.1	-	-	DsbC
HKD1_k127_1580709_79	156978.CIMIT_03740	1.395e-05	55.0	COG4932@1|root,COG4932@2|Bacteria,2I5A4@201174|Actinobacteria,22RHI@1653|Corynebacteriaceae	201174|Actinobacteria	M	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Rib
HKD1_k127_1580709_67	234267.Acid_6377	5.343e-21	105.0	COG2304@1|root,COG2304@2|Bacteria	2|Bacteria	IU	oxidoreductase activity	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HKD1_k127_1580709_42	204669.Acid345_0927	5.212e-53	198.0	COG3234@1|root,COG3234@2|Bacteria,3Y4K7@57723|Acidobacteria,2JMR9@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1175)	-	-	-	ko:K09934	-	-	-	-	ko00000	-	-	-	DUF1175
HKD1_k127_1580709_1	234267.Acid_2300	1.97e-298	977.0	COG2373@1|root,COG2373@2|Bacteria,3Y439@57723|Acidobacteria	57723|Acidobacteria	S	Alpha-2-Macroglobulin	-	-	-	ko:K06894	-	-	-	-	ko00000	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
HKD1_k127_1580709_39	1242864.D187_008155	4.565e-55	220.0	COG0768@1|root,COG2385@1|root,COG0768@2|Bacteria,COG2385@2|Bacteria,1RGJS@1224|Proteobacteria,42RZE@68525|delta/epsilon subdivisions,2WNH8@28221|Deltaproteobacteria	1224|Proteobacteria	D	Stage II sporulation D domain protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID,TPR_6,TPR_8
HKD1_k127_1580709_36	1218103.CIN01S_10_02310	1.995e-58	213.0	COG2094@1|root,COG2094@2|Bacteria,4NP22@976|Bacteroidetes,1I1TP@117743|Flavobacteriia,3ZQNN@59732|Chryseobacterium	976|Bacteroidetes	L	Belongs to the DNA glycosylase MPG family	mpg	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD1_k127_1580709_33	234267.Acid_5931	1.753e-64	229.0	COG0730@1|root,COG0730@2|Bacteria,3Y4IM@57723|Acidobacteria	57723|Acidobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_1580709_65	1267533.KB906735_gene4559	1.732e-21	97.0	COG3369@1|root,COG3369@2|Bacteria,3Y5KG@57723|Acidobacteria,2JJXU@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Iron sulphur-containing domain, CDGSH-type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HKD1_k127_1580709_48	1396141.BATP01000003_gene4881	1.716e-41	164.0	COG3568@1|root,COG3568@2|Bacteria,46X7C@74201|Verrucomicrobia,2IUUK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_1580709_8	204669.Acid345_3333	1.765e-192	611.0	COG0531@1|root,COG0531@2|Bacteria,3Y3Z8@57723|Acidobacteria,2JHZI@204432|Acidobacteriia	204432|Acidobacteriia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_1580709_24	292459.STH2747	3.578e-95	343.0	COG1463@1|root,COG2120@1|root,COG1463@2|Bacteria,COG2120@2|Bacteria,1UYPV@1239|Firmicutes,251C1@186801|Clostridia	186801|Clostridia	Q	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_1580709_17	338966.Ppro_0511	3.636e-126	439.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,42MCT@68525|delta/epsilon subdivisions,2WINW@28221|Deltaproteobacteria,43T20@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD1_k127_1585116_6	1341151.ASZU01000006_gene2893	5.523e-58	213.0	COG2755@1|root,COG2755@2|Bacteria,1VAXZ@1239|Firmicutes,4HNDB@91061|Bacilli	91061|Bacilli	E	Lysophospholipase L1 and related esterases	ycsK	GO:0006629,GO:0008150,GO:0008152,GO:0009056,GO:0016042,GO:0044238,GO:0071704,GO:1901575	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_1585116_11	1396141.BATP01000056_gene3278	9.985e-24	118.0	COG0028@1|root,COG3055@1|root,COG3209@1|root,COG4625@1|root,COG4932@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,COG3209@2|Bacteria,COG4625@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	4.1.3.1	ko:K01637,ko:K20276	ko00630,ko01100,ko01110,ko01120,ko01200,ko02024,map00630,map01100,map01110,map01120,map01200,map02024	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	He_PIG,Laminin_G_3,Malectin
HKD1_k127_1585116_10	479434.Sthe_2454	2.31e-38	165.0	COG3055@1|root,COG3055@2|Bacteria,2GBSZ@200795|Chloroflexi,27ZA5@189775|Thermomicrobia	189775|Thermomicrobia	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1585116_14	1347369.CCAD010000094_gene2222	8.5e-09	65.0	COG3055@1|root,COG3291@1|root,COG3055@2|Bacteria,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	ko:K03933	-	-	-	-	ko00000	-	AA10,CBM73	-	HYR,He_PIG,Laminin_G_3,Malectin,NPCBM,PKD
HKD1_k127_1585116_12	304371.MCP_1979	1.804e-16	82.0	COG0474@1|root,arCOG01578@2157|Archaea,2XW9Y@28890|Euryarchaeota,2N9BB@224756|Methanomicrobia	224756|Methanomicrobia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_1585116_4	204669.Acid345_4026	2.801e-60	223.0	COG0628@1|root,COG0628@2|Bacteria,3Y4A3@57723|Acidobacteria,2JJ4Y@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_1585116_7	211165.AJLN01000047_gene6121	2.59e-56	206.0	COG4803@1|root,COG4803@2|Bacteria,1GJPE@1117|Cyanobacteria,1JJCG@1189|Stigonemataceae	1117|Cyanobacteria	S	Protein of unknown function (DUF1269)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1269
HKD1_k127_1585116_9	639030.JHVA01000001_gene1491	3.443e-41	158.0	COG3247@1|root,COG3247@2|Bacteria,3Y5AN@57723|Acidobacteria,2JJYZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD1_k127_1585116_0	330214.NIDE3498	3.819e-180	579.0	COG2203@1|root,COG3604@1|root,COG2203@2|Bacteria,COG3604@2|Bacteria	2|Bacteria	KT	transcription factor binding	fhlA	GO:0000976,GO:0000984,GO:0001017,GO:0001067,GO:0001150,GO:0001158,GO:0003674,GO:0003676,GO:0003677,GO:0003690,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006351,GO:0006352,GO:0006355,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016043,GO:0016070,GO:0018130,GO:0019219,GO:0019222,GO:0019438,GO:0022607,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031334,GO:0032774,GO:0034641,GO:0034645,GO:0034654,GO:0035326,GO:0042802,GO:0043170,GO:0043254,GO:0043565,GO:0043933,GO:0044085,GO:0044087,GO:0044089,GO:0044212,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0045893,GO:0045935,GO:0046483,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0051128,GO:0051130,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0060255,GO:0065003,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0097159,GO:0097659,GO:1901360,GO:1901362,GO:1901363,GO:1901576,GO:1902680,GO:1903506,GO:1903508,GO:1990837,GO:2000112,GO:2000142,GO:2000144,GO:2001141	-	ko:K02584,ko:K12146,ko:K12266,ko:K15836,ko:K21009	ko02020,ko02025,ko05132,map02020,map02025,map05132	-	-	-	ko00000,ko00001,ko03000	-	-	-	GAF,GAF_2,GAF_3,HTH_8,Sigma54_activat
HKD1_k127_1585116_1	765869.BDW_11285	2.856e-124	409.0	COG0861@1|root,COG0861@2|Bacteria,1MUNR@1224|Proteobacteria,42PJP@68525|delta/epsilon subdivisions,2MTGD@213481|Bdellovibrionales,2WJI0@28221|Deltaproteobacteria	213481|Bdellovibrionales	P	membrane protein, TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD1_k127_1585116_8	1121441.AUCX01000009_gene2470	7.073e-45	168.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,42MN8@68525|delta/epsilon subdivisions,2X5PR@28221|Deltaproteobacteria,2MBC8@213115|Desulfovibrionales	28221|Deltaproteobacteria	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_1585116_5	1267535.KB906767_gene4620	1.087e-59	221.0	COG2234@1|root,COG2234@2|Bacteria,3Y406@57723|Acidobacteria,2JIRZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_1585116_2	391625.PPSIR1_35247	3.979e-107	360.0	COG0473@1|root,COG0473@2|Bacteria,1MUH4@1224|Proteobacteria,42M8G@68525|delta/epsilon subdivisions,2WIYB@28221|Deltaproteobacteria,2YZ2Q@29|Myxococcales	28221|Deltaproteobacteria	C	Dehydrogenase	-	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_1585116_3	234267.Acid_1567	3.782e-66	232.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,3Y466@57723|Acidobacteria	57723|Acidobacteria	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_1598975_5	324602.Caur_2349	1.408e-08	56.0	COG4638@1|root,COG4638@2|Bacteria,2G720@200795|Chloroflexi,377BT@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Rieske 2Fe-2S domain protein	-	-	1.14.15.7	ko:K00479,ko:K00499	ko00260,map00260	-	R07409	RC00087	ko00000,ko00001,ko01000	-	-	-	Rieske,Ring_hydroxyl_A
HKD1_k127_1598975_1	1210884.HG799476_gene15392	3.122e-111	365.0	COG3483@1|root,COG3483@2|Bacteria,2J412@203682|Planctomycetes	203682|Planctomycetes	E	Tryptophan 2,3-dioxygenase	-	-	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD1_k127_1598975_0	643867.Ftrac_2833	2.625e-136	442.0	COG2159@1|root,COG2159@2|Bacteria,4NIGJ@976|Bacteroidetes,47KJH@768503|Cytophagia	976|Bacteroidetes	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HKD1_k127_1598975_2	1120966.AUBU01000006_gene3289	1.205e-50	186.0	COG0662@1|root,COG0662@2|Bacteria,4NFU2@976|Bacteroidetes,47PIW@768503|Cytophagia	976|Bacteroidetes	G	Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate	nbaC	-	1.13.11.6	ko:K00452	ko00380,ko01100,map00380,map01100	M00038	R02665	RC00387	ko00000,ko00001,ko00002,ko01000	-	-	-	3-HAO
HKD1_k127_1598975_3	240016.ABIZ01000001_gene3445	1.052e-48	180.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia,2IUCV@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_1598975_4	497964.CfE428DRAFT_3353	4.971e-10	62.0	COG0476@1|root,COG0607@1|root,COG0476@2|Bacteria,COG0607@2|Bacteria,46SGF@74201|Verrucomicrobia	74201|Verrucomicrobia	H	UBA THIF-type NAD FAD binding protein	thiF	-	2.7.7.80,2.8.1.11	ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF
HKD1_k127_179576_10	525909.Afer_1020	2.763e-227	711.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CNGZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_179576_9	1379270.AUXF01000005_gene764	1.837e-229	733.0	COG2366@1|root,COG2366@2|Bacteria,1ZUMU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Penicillin amidase	-	-	3.5.1.97	ko:K07116	-	-	-	-	ko00000,ko01000	-	-	-	Penicil_amidase
HKD1_k127_179576_139	376686.Fjoh_3843	4.173e-08	66.0	COG0793@1|root,COG0793@2|Bacteria,4NGGJ@976|Bacteroidetes,1HY6W@117743|Flavobacteriia,2NS7E@237|Flavobacterium	976|Bacteroidetes	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HKD1_k127_179576_20	234267.Acid_7272	1.148e-149	488.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,3Y2IR@57723|Acidobacteria	57723|Acidobacteria	P	Metallo-beta-lactamase superfamily	-	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_179576_112	234267.Acid_2953	6.423e-30	131.0	COG2304@1|root,COG2304@2|Bacteria,3Y7U1@57723|Acidobacteria	2|Bacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114,ko:K12511	-	-	-	-	ko00000,ko02000,ko02044	1.A.13.2.2,1.A.13.2.3	-	-	FHA,VWA,VWA_2
HKD1_k127_179576_25	1340493.JNIF01000003_gene4071	1.498e-139	456.0	COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_179576_141	926562.Oweho_3181	4.888e-07	58.0	2DSYW@1|root,33HZI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_97	404589.Anae109_2888	2.948e-41	157.0	COG0346@1|root,COG0346@2|Bacteria,1RJR7@1224|Proteobacteria,43844@68525|delta/epsilon subdivisions,2X3E1@28221|Deltaproteobacteria,2YVN0@29|Myxococcales	28221|Deltaproteobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_179576_64	1157490.EL26_07795	4.135e-77	269.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,4H9WF@91061|Bacilli,2788K@186823|Alicyclobacillaceae	91061|Bacilli	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006275,GO:0008150,GO:0008156,GO:0009889,GO:0009890,GO:0009892,GO:0010556,GO:0010558,GO:0010605,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0019003,GO:0019219,GO:0019222,GO:0030174,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032297,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0050789,GO:0050794,GO:0051052,GO:0051053,GO:0051171,GO:0051172,GO:0051302,GO:0051781,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:0090329,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:2000104,GO:2000112,GO:2000113	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD1_k127_179576_100	1131462.DCF50_p2563	5.555e-38	156.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,260D2@186807|Peptococcaceae	186801|Clostridia	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD1_k127_179576_96	96561.Dole_1732	9.613e-42	164.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,42R1A@68525|delta/epsilon subdivisions,2WMV6@28221|Deltaproteobacteria,2MJG5@213118|Desulfobacterales	28221|Deltaproteobacteria	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD1_k127_179576_63	1123276.KB893279_gene2202	6.769e-79	273.0	COG0823@1|root,COG0823@2|Bacteria,4NITC@976|Bacteroidetes,47R0N@768503|Cytophagia	976|Bacteroidetes	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_179576_125	234267.Acid_0817	9.491e-19	95.0	COG1579@1|root,COG1579@2|Bacteria,3Y509@57723|Acidobacteria	57723|Acidobacteria	S	C4-type zinc ribbon domain	-	-	-	ko:K07164	-	-	-	-	ko00000	-	-	-	zf-RING_7
HKD1_k127_179576_110	314230.DSM3645_14245	1.307e-30	123.0	2BZBR@1|root,32YH6@2|Bacteria,2J41E@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_86	204669.Acid345_1150	1.038e-54	200.0	arCOG09454@1|root,31B41@2|Bacteria,3Y8HD@57723|Acidobacteria,2JNG1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_54	234267.Acid_0489	9.093e-88	294.0	COG3880@1|root,COG3880@2|Bacteria,3Y2KG@57723|Acidobacteria	57723|Acidobacteria	S	Cytochrome c7 and related cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C7
HKD1_k127_179576_4	234267.Acid_0490	0.0	1069.0	COG0243@1|root,COG0437@1|root,COG0243@2|Bacteria,COG0437@2|Bacteria,3Y2Z0@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7,Molydop_binding
HKD1_k127_179576_11	1128421.JAGA01000003_gene2871	1.172e-217	683.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	2|Bacteria	C	Polysulphide reductase, NrfD	nrfD	-	-	ko:K00185	-	-	-	-	ko00000	5.A.3	-	-	DUF3341,NrfD
HKD1_k127_179576_73	1128421.JAGA01000003_gene2872	4.933e-68	235.0	COG2010@1|root,COG2010@2|Bacteria,2NPSE@2323|unclassified Bacteria	2|Bacteria	C	Protein of unknown function (DUF3341)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3341
HKD1_k127_179576_88	204669.Acid345_3000	8.141e-49	184.0	COG2010@1|root,COG2010@2|Bacteria,3Y2MN@57723|Acidobacteria,2JI6T@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_179576_40	1128421.JAGA01000003_gene2874	1.554e-107	361.0	COG4531@1|root,COG4531@2|Bacteria,2NP5Y@2323|unclassified Bacteria	2|Bacteria	P	ABC-type Zn2 transport system, periplasmic component surface adhesin	actF	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_48	234267.Acid_0496	5.179e-95	320.0	COG1999@1|root,COG1999@2|Bacteria,3Y3XH@57723|Acidobacteria	57723|Acidobacteria	S	signal sequence binding	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD1_k127_179576_38	204669.Acid345_2996	2.094e-112	372.0	COG1622@1|root,COG2010@1|root,COG1622@2|Bacteria,COG2010@2|Bacteria,3Y2GR@57723|Acidobacteria,2JHRF@204432|Acidobacteriia	204432|Acidobacteriia	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM,Cytochrom_C
HKD1_k127_179576_7	234267.Acid_0498	8.604e-271	842.0	COG0843@1|root,COG0843@2|Bacteria,3Y2X6@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	-	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_179576_68	1340493.JNIF01000004_gene143	1.46e-72	253.0	COG1845@1|root,COG1845@2|Bacteria,3Y414@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_179576_124	1128421.JAGA01000003_gene2880	6.827e-21	95.0	2ASAK@1|root,31HPU@2|Bacteria,2NQ6K@2323|unclassified Bacteria	2|Bacteria	S	Prokaryotic Cytochrome C oxidase subunit IV	-	-	1.9.3.1	ko:K02277	ko00190,ko01100,map00190,map01100	M00155	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.4	-	-	COX4_pro
HKD1_k127_179576_47	234267.Acid_6197	3.438e-98	331.0	COG2513@1|root,COG2513@2|Bacteria,3Y400@57723|Acidobacteria	57723|Acidobacteria	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HKD1_k127_179576_82	84531.JMTZ01000024_gene4042	4.822e-58	208.0	COG1670@1|root,COG1670@2|Bacteria,1N18Y@1224|Proteobacteria,1S8ZQ@1236|Gammaproteobacteria,1X6VH@135614|Xanthomonadales	135614|Xanthomonadales	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_179576_111	324925.Ppha_0987	4.026e-30	126.0	COG2318@1|root,COG2318@2|Bacteria,1FF75@1090|Chlorobi	1090|Chlorobi	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD1_k127_179576_104	468059.AUHA01000002_gene718	8.997e-36	151.0	COG0793@1|root,COG0793@2|Bacteria,4NEF4@976|Bacteroidetes,1IQVH@117747|Sphingobacteriia	976|Bacteroidetes	M	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ,PDZ_2
HKD1_k127_179576_105	700508.D174_23100	1.8e-34	137.0	COG2764@1|root,COG2764@2|Bacteria,2IFK2@201174|Actinobacteria,238JY@1762|Mycobacteriaceae	201174|Actinobacteria	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_179576_102	1122927.KB895413_gene1427	5.949e-36	143.0	COG3797@1|root,COG3797@2|Bacteria,1VJ1T@1239|Firmicutes,4HQ2E@91061|Bacilli,274WH@186822|Paenibacillaceae	91061|Bacilli	S	Protein of unknown function (DUF1697)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1697
HKD1_k127_179576_49	1382359.JIAL01000001_gene2655	9.625e-95	329.0	COG3667@1|root,COG3667@2|Bacteria,3Y3FP@57723|Acidobacteria,2JITP@204432|Acidobacteriia	204432|Acidobacteriia	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_146	710393.HSUHS1_0927	6.586e-05	51.0	2CCD9@1|root,32NJ2@2|Bacteria,1Q3UE@1224|Proteobacteria,42XU5@68525|delta/epsilon subdivisions,2YQSW@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	YtkA-like	-	-	-	-	-	-	-	-	-	-	-	-	YtkA
HKD1_k127_179576_2	316067.Geob_2478	0.0	1155.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,42NCZ@68525|delta/epsilon subdivisions,2WK3X@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K07787	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.6.1.4	-	-	ACR_tran
HKD1_k127_179576_92	671143.DAMO_1903	2.556e-43	174.0	COG0845@1|root,COG0845@2|Bacteria,2NP97@2323|unclassified Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
HKD1_k127_179576_55	580332.Slit_1984	1.298e-87	294.0	COG2085@1|root,COG2085@2|Bacteria,1NI54@1224|Proteobacteria,2VNIB@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD1_k127_179576_6	1123073.KB899241_gene2256	1.644e-306	954.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,1RMXI@1236|Gammaproteobacteria,1X3Q6@135614|Xanthomonadales	135614|Xanthomonadales	E	Dipeptidyl carboxypeptidase	dcp2	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HKD1_k127_179576_1	1379270.AUXF01000003_gene3608	0.0	1498.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,1ZSS1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Tricorn protease homolog	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_179576_121	1547437.LL06_08345	6.64e-23	102.0	COG1917@1|root,COG1917@2|Bacteria,1N73J@1224|Proteobacteria	1224|Proteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_17	861299.J421_0666	9.859e-161	514.0	COG4447@1|root,COG4447@2|Bacteria,1ZSWZ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_132	558152.IQ37_10635	9.572e-11	71.0	COG2350@1|root,COG2350@2|Bacteria,4NRC1@976|Bacteroidetes,1I447@117743|Flavobacteriia,3ZPYB@59732|Chryseobacterium	976|Bacteroidetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_179576_123	760192.Halhy_1101	2.322e-21	102.0	COG2350@1|root,COG2350@2|Bacteria,4NNMS@976|Bacteroidetes,1ITUD@117747|Sphingobacteriia	976|Bacteroidetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_179576_84	247490.KSU1_C1131	5.406e-56	202.0	COG1881@1|root,COG1881@2|Bacteria,2J1MM@203682|Planctomycetes	203682|Planctomycetes	G	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP,YHYH
HKD1_k127_179576_65	644282.Deba_2613	7.842e-76	265.0	COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	DEAD DEAH box helicase	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DSHCT,DUF3516,Helicase_C
HKD1_k127_179576_77	335543.Sfum_3369	3.147e-64	243.0	COG4581@1|root,COG4581@2|Bacteria,1QUPR@1224|Proteobacteria,42NSH@68525|delta/epsilon subdivisions,2WKD7@28221|Deltaproteobacteria,2MQUA@213462|Syntrophobacterales	28221|Deltaproteobacteria	L	DSHCT	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,DSHCT,DUF3516,Helicase_C
HKD1_k127_179576_72	498761.HM1_1931	8.694e-69	243.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
HKD1_k127_179576_122	1123487.KB892834_gene2599	4.761e-22	106.0	2EJ4R@1|root,33CVZ@2|Bacteria,1P1AA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_36	1254432.SCE1572_13105	6.018e-115	385.0	COG2308@1|root,COG2308@2|Bacteria,1P9A0@1224|Proteobacteria,42PIM@68525|delta/epsilon subdivisions,2WKI0@28221|Deltaproteobacteria,2Z1SA@29|Myxococcales	28221|Deltaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_128	316055.RPE_0316	1.243e-13	75.0	COG1555@1|root,COG1555@2|Bacteria,1N6IU@1224|Proteobacteria,2UEW6@28211|Alphaproteobacteria,3K5TA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3
HKD1_k127_179576_5	330214.NIDE0577	0.0	1065.0	COG0433@1|root,COG0433@2|Bacteria	2|Bacteria	S	helicase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF853,DUF87
HKD1_k127_179576_26	1382359.JIAL01000001_gene558	1.769e-138	447.0	COG0473@1|root,COG0473@2|Bacteria,3Y2VW@57723|Acidobacteria,2JIUD@204432|Acidobacteriia	204432|Acidobacteriia	CE	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.41	ko:K00030	ko00020,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010	R00709	RC00114	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_179576_56	215803.DB30_8393	1.036e-83	291.0	COG0665@1|root,COG0665@2|Bacteria,1MVIZ@1224|Proteobacteria,42REB@68525|delta/epsilon subdivisions,2WNWD@28221|Deltaproteobacteria,2YUH8@29|Myxococcales	28221|Deltaproteobacteria	C	FAD dependent oxidoreductase	thiO	-	1.4.3.19	ko:K03153	ko00730,ko01100,map00730,map01100	-	R07463	RC01788	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_179576_120	1254432.SCE1572_15525	1.325e-23	115.0	COG0265@1|root,COG0526@1|root,COG0265@2|Bacteria,COG0526@2|Bacteria,1QAS6@1224|Proteobacteria,4359M@68525|delta/epsilon subdivisions,2WZKT@28221|Deltaproteobacteria,2Z2BZ@29|Myxococcales	28221|Deltaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,PDZ_2
HKD1_k127_179576_150	460265.Mnod_1406	0.0002588	50.0	COG3182@1|root,COG3182@2|Bacteria,1MUX8@1224|Proteobacteria,2TVQ6@28211|Alphaproteobacteria,1JQUM@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM PepSY-associated TM helix domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
HKD1_k127_179576_80	204669.Acid345_0180	2.727e-59	220.0	COG0785@1|root,COG0785@2|Bacteria	2|Bacteria	O	Cytochrome C biogenesis protein	ccdA	-	1.8.4.11,1.8.4.12	ko:K06196,ko:K12267	-	-	-	-	ko00000,ko01000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD
HKD1_k127_179576_117	518766.Rmar_1898	2.14e-25	119.0	COG0526@1|root,COG0526@2|Bacteria,4PIEG@976|Bacteroidetes,1FK6M@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_179576_142	756272.Plabr_2096	8.465e-07	58.0	COG0526@1|root,COG1729@1|root,COG0526@2|Bacteria,COG1729@2|Bacteria,2IXIV@203682|Planctomycetes	203682|Planctomycetes	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin_8
HKD1_k127_179576_53	429009.Adeg_1604	1.629e-88	302.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,42F72@68295|Thermoanaerobacterales	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_179576_95	1500894.JQNN01000001_gene3284	8.752e-42	160.0	COG3861@1|root,COG3861@2|Bacteria,1MWBU@1224|Proteobacteria,2VR9U@28216|Betaproteobacteria,477EZ@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Cation transport regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_145	414684.RC1_1778	2.207e-05	51.0	COG3409@1|root,COG3409@2|Bacteria,1P0DB@1224|Proteobacteria,2UUZ6@28211|Alphaproteobacteria,2JXJQ@204441|Rhodospirillales	204441|Rhodospirillales	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_179576_98	1002339.HMPREF9373_2172	1.636e-40	161.0	COG0741@1|root,COG0741@2|Bacteria,1MZ4X@1224|Proteobacteria,1S28H@1236|Gammaproteobacteria,3NJTE@468|Moraxellaceae	1236|Gammaproteobacteria	M	Transglycosylase SLT domain	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD1_k127_179576_135	1227497.C491_14567	4.359e-09	65.0	COG3428@1|root,arCOG04619@2157|Archaea,2XWHU@28890|Euryarchaeota,23VDM@183963|Halobacteria	183963|Halobacteria	S	Membrane-flanked domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	bPH_2
HKD1_k127_179576_148	401053.AciPR4_2329	9.613e-05	54.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_179576_8	401053.AciPR4_1847	1.293e-255	806.0	COG1185@1|root,COG1185@2|Bacteria,3Y2UG@57723|Acidobacteria,2JI5F@204432|Acidobacteriia	204432|Acidobacteriia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_179576_113	1051632.TPY_1695	6.391e-29	119.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,3WCM8@538999|Clostridiales incertae sedis	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD1_k127_179576_71	65093.PCC7418_2212	3.949e-69	252.0	COG1252@1|root,COG1252@2|Bacteria,1G26A@1117|Cyanobacteria	1117|Cyanobacteria	C	NADH dehydrogenase, FAD-containing subunit	ndbB	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_179576_130	234267.Acid_6991	5.178e-12	67.0	COG0614@1|root,COG0614@2|Bacteria,3Y8G5@57723|Acidobacteria	57723|Acidobacteria	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_179576_13	1254432.SCE1572_31205	2.021e-181	581.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,42MYA@68525|delta/epsilon subdivisions,2WKFB@28221|Deltaproteobacteria,2YUKP@29|Myxococcales	28221|Deltaproteobacteria	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_179576_21	1123248.KB893333_gene2799	9.847e-149	496.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NHS5@976|Bacteroidetes	976|Bacteroidetes	EU	Peptidase, S9A B C family, catalytic domain protein	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
HKD1_k127_179576_129	1284352.AOIG01000017_gene4494	1.556e-13	74.0	COG4627@1|root,COG4627@2|Bacteria,1UMZS@1239|Firmicutes,4IUPP@91061|Bacilli,277PK@186822|Paenibacillaceae	91061|Bacilli	S	Stress responsive A/B Barrel Domain	-	-	-	-	-	-	-	-	-	-	-	-	Dabb
HKD1_k127_179576_103	1123242.JH636434_gene3566	6.137e-36	153.0	COG0613@1|root,COG0613@2|Bacteria,2J1VB@203682|Planctomycetes	203682|Planctomycetes	S	PHP domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_144	983917.RGE_21170	1.496e-05	57.0	COG1652@1|root,COG4254@1|root,COG1652@2|Bacteria,COG4254@2|Bacteria,1NKA2@1224|Proteobacteria,2VMS2@28216|Betaproteobacteria,1KKQB@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR,LysM
HKD1_k127_179576_93	215803.DB30_6730	2.383e-42	174.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42Q7A@68525|delta/epsilon subdivisions,2WM81@28221|Deltaproteobacteria,2YW8C@29|Myxococcales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
HKD1_k127_179576_15	401053.AciPR4_0872	2.509e-171	543.0	COG1077@1|root,COG1077@2|Bacteria,3Y3VC@57723|Acidobacteria,2JHQ2@204432|Acidobacteriia	204432|Acidobacteriia	D	cell shape determining protein MreB	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_179576_114	589865.DaAHT2_1934	3.786e-28	125.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,42S9I@68525|delta/epsilon subdivisions,2WNTW@28221|Deltaproteobacteria,2MJMG@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD1_k127_179576_149	156889.Mmc1_1414	0.0001156	51.0	COG2891@1|root,COG2891@2|Bacteria	2|Bacteria	M	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins	mreD	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0008360,GO:0016020,GO:0016021,GO:0022603,GO:0022604,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050793,GO:0050794,GO:0051128,GO:0065007,GO:0065008,GO:0071944	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD1_k127_179576_37	234267.Acid_4180	3.396e-114	391.0	COG0768@1|root,COG0768@2|Bacteria,3Y3MX@57723|Acidobacteria	57723|Acidobacteria	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_179576_69	1198114.AciX9_0894	1.167e-70	253.0	COG0772@1|root,COG0772@2|Bacteria,3Y3DZ@57723|Acidobacteria,2JINX@204432|Acidobacteriia	204432|Acidobacteriia	M	Peptidoglycan polymerase that is essential for cell wall elongation	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD1_k127_179576_34	926566.Terro_2493	8.097e-120	415.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y44T@57723|Acidobacteria,2JP2J@204432|Acidobacteriia	204432|Acidobacteriia	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11
HKD1_k127_179576_33	1209989.TepiRe1_1915	3.259e-120	394.0	COG0332@1|root,COG0332@2|Bacteria,1TP0K@1239|Firmicutes,248V8@186801|Clostridia,42ER1@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_179576_119	1408433.JHXV01000005_gene2292	1.013e-24	115.0	COG2746@1|root,COG2746@2|Bacteria,4NWN7@976|Bacteroidetes,1I525@117743|Flavobacteriia,2PBE1@246874|Cryomorphaceae	976|Bacteroidetes	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
HKD1_k127_179576_99	933262.AXAM01000157_gene3163	1.653e-38	159.0	COG0726@1|root,COG0726@2|Bacteria,1RA45@1224|Proteobacteria,42XIA@68525|delta/epsilon subdivisions,2WUHF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_75	222534.KB893670_gene3884	1.747e-64	236.0	COG0438@1|root,COG1216@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,2I5Z7@201174|Actinobacteria,4ESIU@85013|Frankiales	201174|Actinobacteria	M	Glycosyltransferase like family 2	-	-	2.4.1.289	ko:K16870	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	Glyco_tranf_2_3,Glyco_trans_1_4,Glyco_trans_2_3,Glycos_transf_2
HKD1_k127_179576_143	1089553.Tph_c14180	3.948e-06	60.0	COG1807@1|root,COG1807@2|Bacteria,1V1HJ@1239|Firmicutes,249BG@186801|Clostridia,42HAV@68295|Thermoanaerobacterales	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_179576_28	517418.Ctha_0361	5.261e-132	444.0	COG0367@1|root,COG0367@2|Bacteria,1FDEI@1090|Chlorobi	1090|Chlorobi	F	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_179576_16	1183438.GKIL_0464	5.059e-165	530.0	COG0677@1|root,COG0677@2|Bacteria,1G4FW@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K13015	ko00520,map00520	-	R00421	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_179576_27	1267535.KB906767_gene3318	1.693e-134	438.0	COG0665@1|root,COG0665@2|Bacteria,3Y6FK@57723|Acidobacteria,2JKN4@204432|Acidobacteriia	204432|Acidobacteriia	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD1_k127_179576_52	234267.Acid_3432	4.607e-90	317.0	COG1716@1|root,COG2203@1|root,COG2208@1|root,COG1716@2|Bacteria,COG2203@2|Bacteria,COG2208@2|Bacteria,3Y4DC@57723|Acidobacteria	57723|Acidobacteria	T	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GAF_3,SpoIIE
HKD1_k127_179576_134	1122130.AUHN01000005_gene2453	1.78e-09	66.0	COG1714@1|root,COG1714@2|Bacteria,2H4MP@201174|Actinobacteria	201174|Actinobacteria	A	PFAM RDD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_179576_136	1173024.KI912148_gene3324	7.41e-09	68.0	COG1716@1|root,COG1716@2|Bacteria,1GBK0@1117|Cyanobacteria,1JHWR@1189|Stigonemataceae	1117|Cyanobacteria	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD1_k127_179576_78	479434.Sthe_1246	8.673e-61	231.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2G5NM@200795|Chloroflexi,27Z13@189775|Thermomicrobia	189775|Thermomicrobia	KLT	PQQ-like domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PQQ_3,Pkinase
HKD1_k127_179576_118	1521187.JPIM01000053_gene2946	3.236e-25	113.0	COG1716@1|root,COG1716@2|Bacteria,2G9CS@200795|Chloroflexi,375YC@32061|Chloroflexia	32061|Chloroflexia	T	PFAM Forkhead-associated protein	-	-	-	-	-	-	-	-	-	-	-	-	FHA
HKD1_k127_179576_85	204669.Acid345_3323	2.401e-55	213.0	COG0845@1|root,COG0845@2|Bacteria,3Y2XR@57723|Acidobacteria,2JHTV@204432|Acidobacteriia	204432|Acidobacteriia	M	Efflux transporter, RND family, MFP subunit	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_179576_44	1267535.KB906767_gene3077	6.731e-104	343.0	COG1136@1|root,COG1136@2|Bacteria,3Y30Q@57723|Acidobacteria,2JI7R@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_179576_61	1382359.JIAL01000001_gene1381	1.786e-81	288.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria,2JI8C@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_179576_42	1047013.AQSP01000140_gene2536	4.514e-106	357.0	COG0577@1|root,COG0577@2|Bacteria,2NNN0@2323|unclassified Bacteria	2|Bacteria	V	COGs COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_179576_57	234267.Acid_1725	2.524e-83	291.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	2|Bacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_179576_43	234267.Acid_1724	3.888e-104	352.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_179576_133	234267.Acid_1121	1.141e-09	70.0	2BRBT@1|root,32KAC@2|Bacteria,3Y4U0@57723|Acidobacteria	57723|Acidobacteria	S	Yip1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Yip1
HKD1_k127_179576_30	1121861.KB899930_gene199	1.16e-131	427.0	COG4608@1|root,COG4608@2|Bacteria,1NU4K@1224|Proteobacteria,2TQTV@28211|Alphaproteobacteria,2JPRD@204441|Rhodospirillales	204441|Rhodospirillales	E	Belongs to the ABC transporter superfamily	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,oligo_HPY
HKD1_k127_179576_31	867903.ThesuDRAFT_02282	1.514e-120	396.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K02031,ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_179576_67	204669.Acid345_4601	1.171e-72	260.0	COG0457@1|root,COG0457@2|Bacteria,3Y7NG@57723|Acidobacteria,2JMP3@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_179576_12	886293.Sinac_0940	1.419e-200	640.0	COG2234@1|root,COG2234@2|Bacteria,2IZHS@203682|Planctomycetes	203682|Planctomycetes	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_179576_23	926550.CLDAP_00120	2.482e-143	468.0	COG0124@1|root,COG0124@2|Bacteria,2G64E@200795|Chloroflexi	200795|Chloroflexi	J	PFAM tRNA synthetase class II (G H P and S)	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_179576_76	204669.Acid345_4703	2.208e-64	226.0	COG2318@1|root,COG2318@2|Bacteria,3Y4AI@57723|Acidobacteria,2JKRK@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
HKD1_k127_179576_108	63737.Npun_R1214	3.314e-31	126.0	COG0346@1|root,COG0346@2|Bacteria,1GHQQ@1117|Cyanobacteria,1HPG9@1161|Nostocales	1117|Cyanobacteria	C	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_179576_106	1532557.JL37_14160	4.75e-33	132.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2VSJ7@28216|Betaproteobacteria,3T45R@506|Alcaligenaceae	28216|Betaproteobacteria	J	Endoribonuclease L-PSP	abmE	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_179576_58	485913.Krac_2147	3.65e-83	283.0	COG1024@1|root,COG1024@2|Bacteria,2G6G6@200795|Chloroflexi	2|Bacteria	I	PFAM Enoyl-CoA hydratase isomerase	MA20_38145	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_179576_41	1279038.KB907339_gene1329	2.057e-106	357.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,2JPUP@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_179576_19	204669.Acid345_1474	3.512e-152	494.0	COG1113@1|root,COG1113@2|Bacteria	2|Bacteria	E	amino acid transport	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_179576_46	204669.Acid345_1475	9.334e-102	343.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria,2JJXH@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_179576_138	383372.Rcas_1314	1.153e-08	59.0	2BRHQ@1|root,32KGQ@2|Bacteria,2GB33@200795|Chloroflexi,377U1@32061|Chloroflexia	32061|Chloroflexia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_94	383372.Rcas_1313	5.01e-42	160.0	28JE3@1|root,2Z98B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD1_k127_179576_35	1380394.JADL01000024_gene101	1.508e-115	383.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2JRCI@204441|Rhodospirillales	204441|Rhodospirillales	CH	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HKD1_k127_179576_18	1121440.AUMA01000015_gene1851	8.023e-158	511.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,42M7H@68525|delta/epsilon subdivisions,2WIT7@28221|Deltaproteobacteria,2M851@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	iAF987.Gmet_3528	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_179576_140	1250005.PHEL85_0983	1.398e-07	61.0	COG2353@1|root,COG2353@2|Bacteria,4NQKY@976|Bacteroidetes,1I2Z5@117743|Flavobacteriia,3VWJM@52959|Polaribacter	976|Bacteroidetes	S	YceI-like domain	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_179576_50	497964.CfE428DRAFT_4748	1.06e-92	310.0	COG1208@1|root,COG1208@2|Bacteria,46V3X@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_179576_59	237368.SCABRO_03899	2.065e-82	280.0	COG1028@1|root,COG1028@2|Bacteria,2IXE0@203682|Planctomycetes	203682|Planctomycetes	IQ	with different specificities (related to short-chain alcohol	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_179576_107	1278073.MYSTI_03802	1.445e-32	141.0	2DMMW@1|root,32SIJ@2|Bacteria,1N004@1224|Proteobacteria,42TSJ@68525|delta/epsilon subdivisions,2WQHG@28221|Deltaproteobacteria,2YV84@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_3	240015.ACP_2983	0.0	1079.0	COG0653@1|root,COG0653@2|Bacteria,3Y34P@57723|Acidobacteria,2JHSP@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_179576_22	935948.KE386495_gene1938	3.298e-146	481.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,42ERQ@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD1_k127_179576_147	926566.Terro_1798	7.794e-05	54.0	2EM83@1|root,33EX7@2|Bacteria,3Y32M@57723|Acidobacteria,2JHQ1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_91	237368.SCABRO_00409	7.115e-44	166.0	COG1670@1|root,COG1670@2|Bacteria	2|Bacteria	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	BB1022	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_179576_66	477974.Daud_1282	5.666e-73	256.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,260PK@186807|Peptococcaceae	186801|Clostridia	D	Tyrosine recombinase XerD	xerD	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_179576_81	251229.Chro_0773	1.59e-58	207.0	COG0454@1|root,COG0456@2|Bacteria,1GQNY@1117|Cyanobacteria	1117|Cyanobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_179576_89	671143.DAMO_2925	8.529e-47	172.0	COG1993@1|root,COG1993@2|Bacteria,2NPXF@2323|unclassified Bacteria	2|Bacteria	T	Uncharacterized ACR, COG1993	-	-	-	ko:K06199,ko:K09137	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CBS,DUF190
HKD1_k127_179576_90	671143.DAMO_2926	2.181e-45	167.0	COG0239@1|root,COG0239@2|Bacteria,2NQ56@2323|unclassified Bacteria	2|Bacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0008150,GO:0008509,GO:0015075,GO:0015103,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0034220,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944,GO:0098656,GO:0098660,GO:0098661,GO:1903424,GO:1903425	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD1_k127_179576_24	448385.sce6826	5.441e-142	477.0	COG0642@1|root,COG0745@1|root,COG3437@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,COG3437@2|Bacteria,1NRP8@1224|Proteobacteria,439XS@68525|delta/epsilon subdivisions,2X1V1@28221|Deltaproteobacteria,2YYRP@29|Myxococcales	28221|Deltaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,Response_reg
HKD1_k127_179576_0	402777.KB235903_gene788	0.0	2713.0	COG0745@1|root,COG0784@1|root,COG1511@1|root,COG2770@1|root,COG5002@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG1511@2|Bacteria,COG2770@2|Bacteria,COG5002@2|Bacteria,1GHDJ@1117|Cyanobacteria,1H8KY@1150|Oscillatoriales	1117|Cyanobacteria	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HAMP,HATPase_c,HisKA,Response_reg
HKD1_k127_179576_79	251229.Chro_5449	6.692e-60	212.0	COG0454@1|root,COG0454@2|Bacteria,1GR2B@1117|Cyanobacteria	1117|Cyanobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD1_k127_179576_32	1297742.A176_05178	1.857e-120	420.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,42M5E@68525|delta/epsilon subdivisions,2WIV6@28221|Deltaproteobacteria,2YTXT@29|Myxococcales	28221|Deltaproteobacteria	J	Ribonuclease E/G family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD1_k127_179576_127	1122947.FR7_1700	9.555e-15	78.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_179576_83	1499967.BAYZ01000014_gene6406	9.665e-57	207.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	2.1.1.95	ko:K05928	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00112	R07236,R07504,R10491,R10492	RC00003,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD1_k127_179576_60	1499967.BAYZ01000014_gene6405	1.339e-81	283.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_11,Methyltransf_12,PP-binding,ketoacyl-synt
HKD1_k127_179576_74	1499967.BAYZ01000014_gene6405	2.462e-65	235.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_11,Methyltransf_12,PP-binding,ketoacyl-synt
HKD1_k127_179576_137	1089553.Tph_c14180	1.05e-08	68.0	COG1807@1|root,COG1807@2|Bacteria,1V1HJ@1239|Firmicutes,249BG@186801|Clostridia,42HAV@68295|Thermoanaerobacterales	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_179576_39	391612.CY0110_23846	2.024e-109	365.0	COG0463@1|root,COG0463@2|Bacteria,1G03Y@1117|Cyanobacteria,3KGSX@43988|Cyanothece	1117|Cyanobacteria	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HKD1_k127_179576_87	247490.KSU1_D0299	1.343e-49	187.0	COG0500@1|root,COG2226@2|Bacteria,2J1BW@203682|Planctomycetes	203682|Planctomycetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_179576_62	941449.dsx2_1090	2.337e-81	291.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,42WCU@68525|delta/epsilon subdivisions,2X5FB@28221|Deltaproteobacteria,2MGD0@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_179576_101	1333998.M2A_2669	3.885e-36	154.0	COG2244@1|root,COG2244@2|Bacteria,1NCIA@1224|Proteobacteria	1224|Proteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_179576_14	517418.Ctha_2023	1.611e-175	570.0	COG0367@1|root,COG0367@2|Bacteria,1FDEI@1090|Chlorobi	1090|Chlorobi	F	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_179576_51	330214.NIDE3009	2.607e-92	330.0	COG5360@1|root,COG5360@2|Bacteria	2|Bacteria	S	Heparinase II/III-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III,Hepar_II_III_N
HKD1_k127_179576_29	880073.Calab_0614	8.519e-132	431.0	COG0381@1|root,COG0381@2|Bacteria,2NNVT@2323|unclassified Bacteria	2|Bacteria	M	UDP-N-acetylglucosamine 2-epimerase	wecB	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HKD1_k127_179576_131	1454010.JEOE01000001_gene783	1.104e-11	68.0	COG4640@1|root,COG4640@2|Bacteria,2GSZE@201174|Actinobacteria	201174|Actinobacteria	S	Interferon-induced transmembrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CD225
HKD1_k127_179576_115	1173025.GEI7407_2746	1.745e-26	114.0	COG2314@1|root,COG2314@2|Bacteria,1G9J3@1117|Cyanobacteria,1HDPD@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM TM2 domain	-	-	-	-	-	-	-	-	-	-	-	-	TM2
HKD1_k127_179576_116	46234.ANA_C10944	4.98e-26	112.0	2E37T@1|root,32Y7G@2|Bacteria,1GECJ@1117|Cyanobacteria	1117|Cyanobacteria	S	Protein of unknown function (DUF2752)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2752
HKD1_k127_179576_109	391625.PPSIR1_04398	1.149e-30	126.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,42RJS@68525|delta/epsilon subdivisions,2WQSB@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Thioesterase superfamily	yciA	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD1_k127_179576_70	215803.DB30_0292	6.257e-70	241.0	COG2050@1|root,COG2050@2|Bacteria,1RBPE@1224|Proteobacteria,42RKY@68525|delta/epsilon subdivisions,2WNSM@28221|Deltaproteobacteria,2YXUH@29|Myxococcales	28221|Deltaproteobacteria	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_179576_45	1267535.KB906767_gene4240	2.628e-103	361.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HKD1_k127_1826948_15	448385.sce7110	3.253e-39	149.0	COG0454@1|root,COG0456@2|Bacteria,1PWDA@1224|Proteobacteria,43586@68525|delta/epsilon subdivisions,2WZJ8@28221|Deltaproteobacteria,2Z296@29|Myxococcales	28221|Deltaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_1826948_5	485913.Krac_1073	3.19e-112	366.0	COG4221@1|root,COG4221@2|Bacteria,2G6TQ@200795|Chloroflexi	200795|Chloroflexi	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_1826948_1	316056.RPC_4894	2.189e-166	527.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,3JVP4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Aldo keto reductase	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD1_k127_1826948_14	234267.Acid_4188	2.648e-41	161.0	COG1266@1|root,COG1266@2|Bacteria,3Y5CJ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_1826948_10	114615.BRADO6457	7.323e-69	242.0	COG0432@1|root,COG0432@2|Bacteria,1RA5G@1224|Proteobacteria,2U5FG@28211|Alphaproteobacteria,3JY4S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Uncharacterised protein family UPF0047	-	-	-	-	-	-	-	-	-	-	-	-	UPF0047
HKD1_k127_1826948_6	1047013.AQSP01000089_gene1181	4.326e-109	379.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	cyaJ	-	4.6.1.1	ko:K01768,ko:K02483	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko02022	-	-	-	Guanylate_cyc,HTH_18,TPR_16,TPR_19,TPR_2,TPR_8
HKD1_k127_1826948_3	1183438.GKIL_4354	1.265e-134	461.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_1826948_13	1267535.KB906767_gene1916	6.972e-45	165.0	COG1695@1|root,COG1695@2|Bacteria,3Y5C5@57723|Acidobacteria,2JNCX@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD1_k127_1826948_8	196490.AUEZ01000055_gene235	1.01e-77	262.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,2U6KV@28211|Alphaproteobacteria,3JYM4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1826948_11	530564.Psta_0156	1.181e-67	248.0	2F56J@1|root,33XTA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1826948_9	278963.ATWD01000001_gene3838	6.989e-70	237.0	COG1917@1|root,COG1917@2|Bacteria,3Y4HX@57723|Acidobacteria,2JJ92@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_1826948_19	1382306.JNIM01000001_gene2128	5.713e-07	53.0	2BHPS@1|root,32BT1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1826948_0	204669.Acid345_0840	1.009e-254	790.0	COG1249@1|root,COG1249@2|Bacteria,3Y3KM@57723|Acidobacteria,2JICF@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_1826948_7	404589.Anae109_1057	7.249e-108	353.0	COG0346@1|root,COG0346@2|Bacteria,1MV4D@1224|Proteobacteria	1224|Proteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_1826948_16	861299.J421_6000	1.374e-23	107.0	COG0789@1|root,COG0789@2|Bacteria,1ZVAN@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	MerR, DNA binding	-	-	-	ko:K13639	-	-	-	-	ko00000,ko03000	-	-	-	-
HKD1_k127_1826948_20	1081640.AGFU01000067_gene3611	2.669e-06	56.0	COG0662@1|root,COG0662@2|Bacteria,1NVCR@1224|Proteobacteria,2URU1@28211|Alphaproteobacteria,2K599@204457|Sphingomonadales	204457|Sphingomonadales	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2
HKD1_k127_1826948_17	1006000.GKAS_00437	4.399e-18	89.0	COG1226@1|root,COG4651@1|root,COG1226@2|Bacteria,COG4651@2|Bacteria,1MV34@1224|Proteobacteria,1RMM7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	ybaL	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HKD1_k127_1826948_2	266835.14021838	1.741e-151	482.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,2TRUA@28211|Alphaproteobacteria,43JM2@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_1826948_4	485913.Krac_5038	1.251e-112	370.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD1_k127_1826948_12	1218084.BBJK01000013_gene1334	3.464e-54	195.0	COG1917@1|root,COG1917@2|Bacteria,1RGZB@1224|Proteobacteria,2VSYK@28216|Betaproteobacteria,1K7T6@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_1826948_18	1380394.JADL01000002_gene1162	1.312e-17	88.0	COG0782@1|root,COG0782@2|Bacteria,1RHU5@1224|Proteobacteria,2U95I@28211|Alphaproteobacteria,2JX3W@204441|Rhodospirillales	204441|Rhodospirillales	K	Transcription elongation factor, GreA/GreB, C-term	-	-	-	-	-	-	-	-	-	-	-	-	GreA_GreB
HKD1_k127_1834299_4	1502852.FG94_00929	6.388e-09	61.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_1834299_0	861299.J421_5862	2.496e-282	899.0	2DB7A@1|root,2Z7KK@2|Bacteria	2|Bacteria	S	COG NOG06097 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_115
HKD1_k127_1834299_3	452637.Oter_4273	2.329e-111	373.0	COG2755@1|root,COG4677@1|root,COG2755@2|Bacteria,COG4677@2|Bacteria,46X25@74201|Verrucomicrobia,3K9U9@414999|Opitutae	414999|Opitutae	EG	GDSL-like Lipase/Acylhydrolase	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	Lipase_GDSL_2
HKD1_k127_1834299_1	886379.AEWI01000001_gene1828	9.739e-217	694.0	COG1501@1|root,COG1501@2|Bacteria,4P3KJ@976|Bacteroidetes,2FXX7@200643|Bacteroidia,3XKVR@558415|Marinilabiliaceae	976|Bacteroidetes	G	Glycosyl hydrolases family 31	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_31
HKD1_k127_1834299_2	452637.Oter_4281	1.189e-176	568.0	COG3866@1|root,COG3866@2|Bacteria,46SQX@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Pectate lyase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1883693_3	237368.SCABRO_02892	2.391e-15	78.0	28HMZ@1|root,2Z7WD@2|Bacteria,2J2EK@203682|Planctomycetes	203682|Planctomycetes	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_1883693_0	666684.AfiDRAFT_1907	0.0	1143.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3JVJZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_1883693_1	1006004.GBAG_0262	3.164e-164	526.0	COG0641@1|root,COG0641@2|Bacteria,1MX3M@1224|Proteobacteria,1RN4R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	radical SAM domain protein	aslB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_1883693_2	1267535.KB906767_gene1129	3.08e-141	482.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_191468_14	1156937.MFUM_310039	7.387e-21	94.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia,37HA9@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	S	RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_191468_13	1396141.BATP01000059_gene2386	3.005e-23	102.0	COG0361@1|root,COG0361@2|Bacteria,46T5J@74201|Verrucomicrobia,2IUS9@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_191468_2	340.xcc-b100_0126	2.678e-138	451.0	COG2755@1|root,COG2755@2|Bacteria,1MXBN@1224|Proteobacteria,1RQJF@1236|Gammaproteobacteria,1X4T4@135614|Xanthomonadales	135614|Xanthomonadales	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_191468_18	96561.Dole_1061	3.036e-06	59.0	COG1073@1|root,COG1073@2|Bacteria,1RBV1@1224|Proteobacteria,42M9M@68525|delta/epsilon subdivisions,2WM64@28221|Deltaproteobacteria,2MJJ0@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD1_k127_191468_17	1535422.ND16A_1925	6.974e-08	65.0	COG1073@1|root,COG1073@2|Bacteria,1RBP3@1224|Proteobacteria,1S216@1236|Gammaproteobacteria,2Q5Y1@267889|Colwelliaceae	1236|Gammaproteobacteria	S	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD1_k127_191468_6	331869.BAL199_00165	5.001e-72	254.0	COG1262@1|root,COG4249@1|root,COG1262@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TRW5@28211|Alphaproteobacteria,4BQPK@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,PG_binding_1,Peptidase_C14,SH3_3
HKD1_k127_191468_10	1396141.BATP01000039_gene1336	1.985e-40	155.0	COG1595@1|root,COG1595@2|Bacteria,46VX9@74201|Verrucomicrobia,2IUIG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_191468_19	452637.Oter_0300	1.987e-05	55.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	DUF3379
HKD1_k127_191468_15	1156937.MFUM_310045	8.332e-19	96.0	2CK2Q@1|root,30XDX@2|Bacteria,46X4H@74201|Verrucomicrobia,37HA6@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_191468_4	1336235.JAEG01000006_gene779	4.68e-106	353.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,2TR16@28211|Alphaproteobacteria,4BBN8@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the mandelate racemase muconate lactonizing enzyme family	ycjG	GO:0003674,GO:0003824,GO:0016853,GO:0016854,GO:0016855	5.1.1.20	ko:K19802	-	-	R10938	RC03309	ko00000,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_191468_1	1382359.JIAL01000001_gene1690	9.64e-191	616.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3ZP@57723|Acidobacteria,2JI7Y@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_191468_12	68570.DC74_6164	4.839e-26	113.0	COG0454@1|root,COG0454@2|Bacteria,2I4WW@201174|Actinobacteria	201174|Actinobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_191468_8	1131269.AQVV01000065_gene1812	2.423e-53	192.0	COG0431@1|root,COG0431@2|Bacteria	2|Bacteria	S	FMN reductase (NADPH) activity	ssuE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006790,GO:0006805,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008150,GO:0008152,GO:0008752,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009111,GO:0009267,GO:0009308,GO:0009310,GO:0009410,GO:0009605,GO:0009970,GO:0009987,GO:0009991,GO:0010181,GO:0016043,GO:0016054,GO:0016491,GO:0016645,GO:0016646,GO:0019439,GO:0019694,GO:0019752,GO:0022607,GO:0031667,GO:0031668,GO:0031669,GO:0032553,GO:0032787,GO:0033554,GO:0034641,GO:0036094,GO:0042178,GO:0042221,GO:0042365,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0042594,GO:0043167,GO:0043168,GO:0043420,GO:0043421,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044273,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046218,GO:0046306,GO:0046395,GO:0046483,GO:0046700,GO:0048037,GO:0050662,GO:0050896,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0051716,GO:0052873,GO:0055114,GO:0065003,GO:0070887,GO:0071466,GO:0071496,GO:0071704,GO:0071840,GO:0072329,GO:0097159,GO:0097367,GO:1901265,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.5.1.38,1.5.1.45	ko:K00299,ko:K16902	ko00380,ko00740,ko00920,ko01100,map00380,map00740,map00920,map01100	-	R05706,R07210,R09517,R09520,R09748,R10206	RC00046,RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	iAF1260.b0937,iB21_1397.B21_00948,iBWG_1329.BWG_0789,iE2348C_1286.E2348C_0930,iECBD_1354.ECBD_2658,iECB_1328.ECB_00941,iECDH10B_1368.ECDH10B_1007,iECDH1ME8569_1439.ECDH1ME8569_0888,iECD_1391.ECD_00941,iECIAI1_1343.ECIAI1_0978,iECO103_1326.ECO103_0982,iECW_1372.ECW_m1047,iEKO11_1354.EKO11_2893,iETEC_1333.ETEC_1005,iEcDH1_1363.EcDH1_2706,iEcE24377_1341.EcE24377A_1052,iEcHS_1320.EcHS_A1046,iEcolC_1368.EcolC_2659,iJO1366.b0937,iSB619.SA_RS01880,iSbBS512_1146.SbBS512_E2381,iUMNK88_1353.UMNK88_1092,iWFL_1372.ECW_m1047,iY75_1357.Y75_RS04870	FMN_red
HKD1_k127_191468_7	926560.KE387026_gene4310	3.528e-55	198.0	COG4101@1|root,COG4101@2|Bacteria	2|Bacteria	G	3-hydroxyanthranilate 3,4-dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_191468_5	526222.Desal_2833	2.428e-78	265.0	COG2818@1|root,COG2818@2|Bacteria,1R9X5@1224|Proteobacteria,42QWV@68525|delta/epsilon subdivisions,2WMPT@28221|Deltaproteobacteria,2MB6B@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD1_k127_191468_9	452637.Oter_2243	3.902e-53	198.0	2EW42@1|root,33PH9@2|Bacteria,46U23@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_191468_0	452637.Oter_1325	3.43e-191	602.0	COG1180@1|root,COG1180@2|Bacteria	2|Bacteria	C	glycyl-radical enzyme activating activity	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_191468_3	497964.CfE428DRAFT_1406	1.439e-106	353.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,46S8W@74201|Verrucomicrobia	74201|Verrucomicrobia	P	PFAM CBS domain containing protein	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD1_k127_2012492_14	1177179.A11A3_05254	6.565e-136	465.0	COG5184@1|root,COG5276@1|root,COG5184@2|Bacteria,COG5276@2|Bacteria,1QUHA@1224|Proteobacteria,1T1YV@1236|Gammaproteobacteria,1XS25@135619|Oceanospirillales	135619|Oceanospirillales	DZ	Thrombospondin type 3 repeat	-	-	-	-	-	-	-	-	-	-	-	-	TSP_3
HKD1_k127_2012492_38	1237149.C900_00068	3.701e-55	220.0	COG2374@1|root,COG4935@1|root,COG2374@2|Bacteria,COG4935@2|Bacteria,4NHFV@976|Bacteroidetes,47M74@768503|Cytophagia	976|Bacteroidetes	M	endonuclease I	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,CHB_HEX_C_1,Exo_endo_phos
HKD1_k127_2012492_13	1267535.KB906767_gene873	1.086e-138	449.0	COG4948@1|root,COG4948@2|Bacteria,3Y2QQ@57723|Acidobacteria,2JITG@204432|Acidobacteriia	204432|Acidobacteriia	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_2012492_30	575540.Isop_1915	3.178e-87	301.0	COG0624@1|root,COG0624@2|Bacteria,2IZ39@203682|Planctomycetes	203682|Planctomycetes	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_2012492_29	1183438.GKIL_1098	1.715e-89	302.0	COG0708@1|root,COG0708@2|Bacteria,1G29X@1117|Cyanobacteria	1117|Cyanobacteria	L	Exodeoxyribonuclease iii	xthA	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD1_k127_2012492_16	1267534.KB906759_gene1889	1.888e-131	442.0	COG0671@1|root,COG0671@2|Bacteria,3Y6DG@57723|Acidobacteria	57723|Acidobacteria	I	phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_69	697282.Mettu_2753	0.0001958	47.0	COG1943@1|root,COG1943@2|Bacteria,1NA94@1224|Proteobacteria,1SRKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_2012492_15	391625.PPSIR1_32307	8.091e-135	439.0	COG0167@1|root,COG0167@2|Bacteria,1MXER@1224|Proteobacteria,42YD3@68525|delta/epsilon subdivisions,2WTVV@28221|Deltaproteobacteria,2YU0M@29|Myxococcales	28221|Deltaproteobacteria	C	4Fe-4S dicluster domain	yeiA	-	1.3.1.1	ko:K17723	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046	R00977,R01414,R11026	RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh,Fer4_21
HKD1_k127_2012492_45	266940.Krad_2669	2.014e-48	179.0	COG0251@1|root,COG0251@2|Bacteria,2IIB2@201174|Actinobacteria	201174|Actinobacteria	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_2012492_12	1396141.BATP01000059_gene2564	9.03e-147	469.0	COG0388@1|root,COG0388@2|Bacteria,46S7B@74201|Verrucomicrobia,2ITNA@203494|Verrucomicrobiae	203494|Verrucomicrobiae	K	Carbon-nitrogen hydrolase	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD1_k127_2012492_3	86416.Clopa_1052	4.175e-174	562.0	COG1953@1|root,COG1953@2|Bacteria,1TS5W@1239|Firmicutes,247WK@186801|Clostridia,36VS3@31979|Clostridiaceae	186801|Clostridia	FH	PFAM Permease for cytosine purines, uracil, thiamine, allantoin	pucI	-	-	ko:K03457	-	-	-	-	ko00000	2.A.39	-	-	Transp_cyt_pur
HKD1_k127_2012492_5	1267533.KB906734_gene3657	3.656e-169	546.0	COG2939@1|root,COG2939@2|Bacteria,3Y3DM@57723|Acidobacteria,2JIJH@204432|Acidobacteriia	57723|Acidobacteria	E	Serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HKD1_k127_2012492_2	215803.DB30_5624	1.187e-195	620.0	COG0044@1|root,COG0044@2|Bacteria,1MW10@1224|Proteobacteria,42PXH@68525|delta/epsilon subdivisions,2WKEX@28221|Deltaproteobacteria,2YTWX@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD1_k127_2012492_36	376686.Fjoh_0951	3.258e-58	205.0	COG1943@1|root,COG1943@2|Bacteria,4NQTF@976|Bacteroidetes,1I1DP@117743|Flavobacteriia,2NW3U@237|Flavobacterium	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_2012492_10	234267.Acid_7662	2.288e-155	501.0	COG0160@1|root,COG0160@2|Bacteria,3Y4EV@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.55	ko:K00823,ko:K15372	ko00250,ko00410,ko00430,ko00640,ko00650,ko01100,ko01120,map00250,map00410,map00430,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R01684	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_2012492_8	525904.Tter_0560	5.011e-157	509.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_2012492_26	639030.JHVA01000001_gene2173	3.731e-100	334.0	2B47E@1|root,31WYM@2|Bacteria,3Y45I@57723|Acidobacteria,2JIH8@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_22	357808.RoseRS_2094	1.812e-122	410.0	COG0318@1|root,COG0318@2|Bacteria,2G7VC@200795|Chloroflexi	200795|Chloroflexi	IQ	AMP-binding enzyme C-terminal domain	-	-	6.2.1.3	ko:K00666,ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD1_k127_2012492_55	1172180.KB911795_gene7681	2.016e-23	110.0	COG0672@1|root,COG0672@2|Bacteria,2GJ22@201174|Actinobacteria	201174|Actinobacteria	P	Iron permease FTR1	-	-	-	ko:K07243	-	-	-	-	ko00000,ko02000	2.A.108.1,2.A.108.2	-	-	FTR1
HKD1_k127_2012492_62	1218108.KB908292_gene1646	7.049e-13	81.0	COG3170@1|root,COG3170@2|Bacteria,4NF47@976|Bacteroidetes,1HXT1@117743|Flavobacteriia	976|Bacteroidetes	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_2012492_67	865937.Gilli_2221	2.15e-08	67.0	COG3170@1|root,COG3170@2|Bacteria,4NF47@976|Bacteroidetes,1HXT1@117743|Flavobacteriia,2P5GA@244698|Gillisia	976|Bacteroidetes	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_2012492_33	316067.Geob_2402	1.254e-66	236.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,42N5N@68525|delta/epsilon subdivisions,2WMJ5@28221|Deltaproteobacteria,43UGT@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	GO:0003674,GO:0003824,GO:0004590,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD1_k127_2012492_25	272134.KB731324_gene1653	1.088e-102	346.0	COG0167@1|root,COG0167@2|Bacteria,1G1C2@1117|Cyanobacteria,1H89S@1150|Oscillatoriales	1117|Cyanobacteria	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_2012492_34	373903.Hore_09350	8.717e-66	231.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,3WAIW@53433|Halanaerobiales	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
HKD1_k127_2012492_20	338963.Pcar_1615	3.204e-124	407.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,42NMR@68525|delta/epsilon subdivisions,2WJQR@28221|Deltaproteobacteria,43S21@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	pyrB	GO:0003674,GO:0003824,GO:0004070,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009165,GO:0009218,GO:0009220,GO:0009259,GO:0009260,GO:0009987,GO:0016740,GO:0016741,GO:0016743,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_2012492_11	1267535.KB906767_gene1158	4.795e-151	492.0	COG0044@1|root,COG0044@2|Bacteria,3Y34R@57723|Acidobacteria,2JIA3@204432|Acidobacteriia	204432|Acidobacteriia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_2012492_60	102232.GLO73106DRAFT_00041250	5.502e-15	91.0	COG2931@1|root,COG3210@1|root,COG2931@2|Bacteria,COG3210@2|Bacteria,1G67W@1117|Cyanobacteria	1117|Cyanobacteria	Q	polymorphic outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,HemolysinCabind
HKD1_k127_2012492_23	686340.Metal_2132	4.544e-119	429.0	COG2373@1|root,COG3209@1|root,COG2373@2|Bacteria,COG3209@2|Bacteria,1QV7E@1224|Proteobacteria,1T3HZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	TIGRFAM Outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_64	909943.HIMB100_00000010	2.502e-10	75.0	COG3210@1|root,COG3210@2|Bacteria,1QUXB@1224|Proteobacteria	1224|Proteobacteria	U	6-phosphogluconolactonase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_5,Cadherin_3,Calx-beta,DUF11,DUF4347,He_PIG,OmpA_membrane,PATR,VCBS
HKD1_k127_2012492_65	926562.Oweho_2142	1.88e-09	63.0	COG1225@1|root,COG1225@2|Bacteria,4NGWI@976|Bacteroidetes,1IJ05@117743|Flavobacteriia	976|Bacteroidetes	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_2012492_1	1382359.JIAL01000001_gene1908	4.225e-296	926.0	COG1506@1|root,COG1506@2|Bacteria,3Y3EW@57723|Acidobacteria,2JNZU@204432|Acidobacteriia	204432|Acidobacteriia	E	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
HKD1_k127_2012492_7	1267534.KB906758_gene2398	2.329e-162	524.0	COG3220@1|root,COG3220@2|Bacteria,3Y62Z@57723|Acidobacteria,2JKB2@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF692)	-	-	-	-	-	-	-	-	-	-	-	-	DUF692
HKD1_k127_2012492_66	1443665.JACA01000014_gene4463	8.607e-09	63.0	2C5RC@1|root,33ZDX@2|Bacteria,4P4DP@976|Bacteroidetes,1I9WU@117743|Flavobacteriia,2YJJN@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_9	861299.J421_2314	2.216e-156	507.0	COG0477@1|root,COG2814@2|Bacteria,1ZT84@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_2012492_24	1123248.KB893327_gene788	7.34e-108	356.0	COG0258@1|root,COG0258@2|Bacteria	2|Bacteria	L	nuclease activity	polA	GO:0003674,GO:0003676,GO:0003677,GO:0003824,GO:0003887,GO:0004518,GO:0004527,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006281,GO:0006284,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008408,GO:0008409,GO:0009058,GO:0009059,GO:0009987,GO:0016740,GO:0016772,GO:0016779,GO:0016787,GO:0016788,GO:0018130,GO:0019438,GO:0033554,GO:0034061,GO:0034641,GO:0034645,GO:0034654,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0071897,GO:0090304,GO:0090305,GO:0097159,GO:0140097,GO:1901360,GO:1901362,GO:1901363,GO:1901576	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD1_k127_2012492_0	234267.Acid_4922	0.0	1040.0	COG2366@1|root,COG2366@2|Bacteria,3Y38M@57723|Acidobacteria	57723|Acidobacteria	S	Penicillin amidase	-	-	3.5.1.11	ko:K01434	ko00311,ko01130,map00311,map01130	-	R02170	RC00166,RC00328	ko00000,ko00001,ko01000,ko01002	-	-	-	Penicil_amidase
HKD1_k127_2012492_41	861299.J421_5843	2.804e-53	198.0	COG0652@1|root,COG0652@2|Bacteria,1ZUD7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
HKD1_k127_2012492_51	1121123.AUAO01000003_gene2225	2.78e-31	128.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,2KJ9S@204458|Caulobacterales	204458|Caulobacterales	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_2012492_32	1396141.BATP01000028_gene2295	4.394e-72	248.0	COG3832@1|root,COG3832@2|Bacteria,46VGW@74201|Verrucomicrobia,2IURS@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_2012492_68	289376.THEYE_A0093	8.754e-05	53.0	COG2825@1|root,COG2825@2|Bacteria,3J1AH@40117|Nitrospirae	40117|Nitrospirae	M	Evidence 3 Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD1_k127_2012492_53	509190.Cseg_0271	1.15e-25	112.0	COG5646@1|root,COG5646@2|Bacteria,1NKMZ@1224|Proteobacteria,2UJHW@28211|Alphaproteobacteria,2KJ5I@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD1_k127_2012492_42	1123248.KB893315_gene3017	3.492e-53	190.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_2012492_48	323848.Nmul_A1375	3.634e-41	157.0	COG2764@1|root,COG2764@2|Bacteria,1N0S4@1224|Proteobacteria,2VU64@28216|Betaproteobacteria,3738I@32003|Nitrosomonadales	28216|Betaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	ko:K04750	-	-	-	-	ko00000	-	-	-	3-dmu-9_3-mt
HKD1_k127_2012492_35	331869.BAL199_16858	3.377e-59	210.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD1_k127_2012492_43	1134912.AJTV01000002_gene1748	1.06e-52	194.0	2AC8B@1|root,311T0@2|Bacteria,1NK0P@1224|Proteobacteria,2VD5M@28211|Alphaproteobacteria,3713U@31993|Methylocystaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_19	234267.Acid_1969	1.105e-125	415.0	COG1228@1|root,COG1228@2|Bacteria,3Y47R@57723|Acidobacteria	2|Bacteria	Q	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_2012492_46	278963.ATWD01000002_gene823	1.28e-44	189.0	COG0457@1|root,COG0457@2|Bacteria,3Y59I@57723|Acidobacteria,2JJNP@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_31	1122604.JONR01000025_gene4602	3.794e-72	280.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_2012492_17	234267.Acid_7916	4.498e-128	461.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD1_k127_2012492_40	234267.Acid_1209	2.961e-54	196.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_2012492_27	450851.PHZ_c1673	3.703e-94	318.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2012492_70	1235835.C814_00359	0.0006981	51.0	COG1917@1|root,COG1917@2|Bacteria	2|Bacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_2012492_28	1122223.KB890688_gene1648	1.008e-89	299.0	COG0288@1|root,COG0288@2|Bacteria,1WKSX@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_2012492_54	358681.BBR47_19240	7.858e-25	108.0	2C3PV@1|root,3307H@2|Bacteria,1VJ1P@1239|Firmicutes,4HPE6@91061|Bacilli	91061|Bacilli	S	Protein of unknown function (DUF2834)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2834
HKD1_k127_2012492_21	204669.Acid345_1712	7.188e-124	416.0	COG1680@1|root,COG1680@2|Bacteria,3Y3WB@57723|Acidobacteria,2JJDH@204432|Acidobacteriia	204432|Acidobacteriia	V	PFAM beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_2012492_49	1380394.JADL01000002_gene1628	6.082e-39	149.0	COG5552@1|root,COG5552@2|Bacteria,1MZBV@1224|Proteobacteria,2UC5C@28211|Alphaproteobacteria,2JXIK@204441|Rhodospirillales	204441|Rhodospirillales	S	Uncharacterized conserved protein (DUF2277)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2277
HKD1_k127_2012492_47	760117.JN27_03925	3.003e-41	164.0	COG0596@1|root,COG0596@2|Bacteria,1N252@1224|Proteobacteria,2WBR8@28216|Betaproteobacteria,476BD@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_2012492_4	234267.Acid_7338	1.296e-173	558.0	COG1228@1|root,COG1228@2|Bacteria,3Y39J@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_2012492_50	83406.HDN1F_31130	3.524e-37	147.0	COG0454@1|root,COG0456@2|Bacteria,1N8A4@1224|Proteobacteria,1S9CR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_2012492_61	697282.Mettu_2753	1.841e-13	72.0	COG1943@1|root,COG1943@2|Bacteria,1NA94@1224|Proteobacteria,1SRKA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_2012492_57	1122605.KB893645_gene940	9.067e-21	98.0	COG3832@1|root,COG3832@2|Bacteria,4P9GQ@976|Bacteroidetes,1IZC2@117747|Sphingobacteriia	976|Bacteroidetes	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_2012492_37	1268068.PG5_54060	1.807e-55	197.0	COG3795@1|root,COG3795@2|Bacteria,1RCZT@1224|Proteobacteria,1S69N@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_2012492_39	404589.Anae109_1540	5.967e-55	194.0	COG3324@1|root,COG3324@2|Bacteria	2|Bacteria	E	translation initiation factor activity	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_2012492_44	272134.KB731324_gene6666	1.814e-49	178.0	COG3795@1|root,COG3795@2|Bacteria,1G6M3@1117|Cyanobacteria,1HBWD@1150|Oscillatoriales	1117|Cyanobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_2012492_52	179408.Osc7112_0483	1.237e-30	126.0	COG3795@1|root,COG3795@2|Bacteria,1G6M3@1117|Cyanobacteria,1HBWD@1150|Oscillatoriales	1117|Cyanobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_2012492_6	32057.KB217478_gene3536	7.079e-169	544.0	COG4941@1|root,COG4941@2|Bacteria,1G1YQ@1117|Cyanobacteria,1HRSK@1161|Nostocales	1117|Cyanobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_2012492_18	316067.Geob_3650	3.863e-126	413.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HKD1_k127_2037976_42	234267.Acid_7303	1.941e-16	78.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria	57723|Acidobacteria	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_2037976_7	1242864.D187_001445	6.079e-115	376.0	COG5285@1|root,COG5285@2|Bacteria,1Q78R@1224|Proteobacteria,438ZF@68525|delta/epsilon subdivisions,2X44Q@28221|Deltaproteobacteria,2YY90@29|Myxococcales	28221|Deltaproteobacteria	Q	Phytanoyl-CoA dioxygenase (PhyH)	-	-	1.14.11.18	ko:K00477	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	PhyH
HKD1_k127_2037976_1	1121904.ARBP01000007_gene2888	1.085e-263	841.0	COG0612@1|root,COG0612@2|Bacteria,4NFY0@976|Bacteroidetes,47MF6@768503|Cytophagia	976|Bacteroidetes	S	Belongs to the peptidase M16 family	pqqL	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_2037976_6	335543.Sfum_0518	5.638e-152	505.0	COG4188@1|root,COG4188@2|Bacteria,1Q4K6@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase family 6	-	-	-	-	-	-	-	-	-	-	-	-	Chlorophyllase2
HKD1_k127_2037976_30	234267.Acid_4775	1.521e-34	153.0	COG1361@1|root,COG1649@1|root,COG1361@2|Bacteria,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,Glyco_hydro_42M,PKD,SLH,WG_beta_rep
HKD1_k127_2037976_46	1415166.NONO_c26860	9.66e-10	72.0	COG2706@1|root,COG2706@2|Bacteria	2|Bacteria	G	6-phosphogluconolactonase activity	-	-	3.1.1.31	ko:K07404	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Dabb,Lactonase,PKD,VCBS
HKD1_k127_2037976_19	1382359.JIAL01000001_gene2402	1.952e-67	241.0	COG0667@1|root,COG0667@2|Bacteria,3Y6M9@57723|Acidobacteria,2JM6A@204432|Acidobacteriia	204432|Acidobacteriia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_2037976_28	485918.Cpin_7030	1.355e-37	147.0	COG4232@1|root,COG4232@2|Bacteria,4NQID@976|Bacteroidetes,1ISZ1@117747|Sphingobacteriia	976|Bacteroidetes	CO	Disulphide bond corrector protein DsbC	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
HKD1_k127_2037976_49	106648.BBLJ01000054_gene3798	2.939e-05	48.0	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,1S4YH@1236|Gammaproteobacteria,3NT8Q@468|Moraxellaceae	1236|Gammaproteobacteria	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6,Terminase_6C
HKD1_k127_2037976_5	1267535.KB906767_gene4427	1.116e-152	496.0	COG1206@1|root,COG1206@2|Bacteria,3Y2KD@57723|Acidobacteria,2JIGU@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD1_k127_2037976_33	234267.Acid_5910	2.788e-27	124.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_2037976_12	316067.Geob_0753	1.498e-92	314.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,42Q4U@68525|delta/epsilon subdivisions,2WJ08@28221|Deltaproteobacteria,43U9P@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Phage integrase, N-terminal SAM-like domain	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_2037976_45	395961.Cyan7425_4186	6.458e-11	75.0	COG0484@1|root,COG0484@2|Bacteria,1G0V5@1117|Cyanobacteria,3KFN3@43988|Cyanothece	1117|Cyanobacteria	O	PFAM heat shock protein DnaJ domain protein	dnaJ3	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_2037976_31	311424.DhcVS_565	3.599e-33	140.0	COG3437@1|root,COG3437@2|Bacteria,2G6QF@200795|Chloroflexi,34CZJ@301297|Dehalococcoidia	301297|Dehalococcoidia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,Response_reg
HKD1_k127_2037976_48	553177.CAPSP0001_0382	1.353e-07	63.0	COG3392@1|root,COG3392@2|Bacteria,4NIHU@976|Bacteroidetes,1HZED@117743|Flavobacteriia,1ESX2@1016|Capnocytophaga	976|Bacteroidetes	H	D12 class N6 adenine-specific DNA methyltransferase	-	-	2.1.1.72	ko:K07318	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	MethyltransfD12
HKD1_k127_2037976_38	311424.DhcVS_1080	1.235e-21	99.0	COG1278@1|root,COG1278@2|Bacteria,2G79W@200795|Chloroflexi,34DCQ@301297|Dehalococcoidia	301297|Dehalococcoidia	K	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD1_k127_2037976_10	237368.SCABRO_02433	4.208e-95	320.0	COG0123@1|root,COG0123@2|Bacteria,2IXK9@203682|Planctomycetes	203682|Planctomycetes	BQ	including yeast histone deacetylase and acetoin utilization protein	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD1_k127_2037976_26	1173028.ANKO01000106_gene307	8.248e-48	191.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_2037976_25	880072.Desac_2741	5.598e-51	199.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_2037976_51	55529.EKX38433	8.007e-05	55.0	COG0457@1|root,KOG0553@2759|Eukaryota	2759|Eukaryota	O	negative regulation of ER-associated ubiquitin-dependent protein catabolic process	SGTB	GO:0003674,GO:0005198,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006457,GO:0006508,GO:0006511,GO:0006605,GO:0006612,GO:0006620,GO:0006807,GO:0006810,GO:0006886,GO:0006950,GO:0006996,GO:0007029,GO:0008022,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009892,GO:0009893,GO:0009894,GO:0009895,GO:0009896,GO:0009987,GO:0010033,GO:0010243,GO:0010256,GO:0010498,GO:0010604,GO:0010605,GO:0015031,GO:0015833,GO:0016020,GO:0016043,GO:0016192,GO:0019222,GO:0019538,GO:0019941,GO:0030162,GO:0030163,GO:0030433,GO:0030544,GO:0031072,GO:0031323,GO:0031324,GO:0031325,GO:0031329,GO:0031330,GO:0031331,GO:0031333,GO:0032268,GO:0032269,GO:0032270,GO:0032434,GO:0032435,GO:0032436,GO:0032459,GO:0032460,GO:0032947,GO:0032991,GO:0033036,GO:0033365,GO:0033554,GO:0034613,GO:0034976,GO:0036503,GO:0042176,GO:0042177,GO:0042221,GO:0042802,GO:0042803,GO:0042886,GO:0043161,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043254,GO:0043621,GO:0043632,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0044877,GO:0045047,GO:0045048,GO:0045184,GO:0045732,GO:0045861,GO:0045862,GO:0046907,GO:0046982,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048584,GO:0048585,GO:0050789,GO:0050794,GO:0050896,GO:0051087,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051173,GO:0051179,GO:0051205,GO:0051234,GO:0051246,GO:0051247,GO:0051248,GO:0051603,GO:0051641,GO:0051649,GO:0051716,GO:0060255,GO:0061024,GO:0061136,GO:0065007,GO:0070727,GO:0070972,GO:0071702,GO:0071704,GO:0071705,GO:0071816,GO:0071840,GO:0072379,GO:0072380,GO:0072594,GO:0072599,GO:0072657,GO:0080090,GO:0080134,GO:0080135,GO:0090150,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901799,GO:1901800,GO:1903050,GO:1903051,GO:1903052,GO:1903069,GO:1903070,GO:1903071,GO:1903332,GO:1903334,GO:1903362,GO:1903363,GO:1903364,GO:1903573,GO:1903644,GO:1903646,GO:1904288,GO:1904292,GO:1904293,GO:1904294,GO:1905897,GO:1905898,GO:2000058,GO:2000059,GO:2000060	-	ko:K16365	-	-	-	-	ko00000,ko04147,ko04516	-	-	-	SGTA_dimer,TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_2037976_23	983917.RGE_30750	2.339e-54	202.0	COG0412@1|root,COG0412@2|Bacteria,1Q876@1224|Proteobacteria,2WC50@28216|Betaproteobacteria,1KP8A@119065|unclassified Burkholderiales	28216|Betaproteobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD1_k127_2037976_17	679926.Mpet_2610	1.345e-79	275.0	COG0548@1|root,arCOG00862@2157|Archaea,2XTW9@28890|Euryarchaeota,2N912@224756|Methanomicrobia	224756|Methanomicrobia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_2037976_11	1123377.AUIV01000008_gene1384	1.391e-93	317.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,1S7AW@1236|Gammaproteobacteria,1X35E@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the ATCase OTCase family	argF	GO:0000050,GO:0003674,GO:0003824,GO:0004585,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006525,GO:0006526,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009064,GO:0009084,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0016743,GO:0019627,GO:0019752,GO:0034641,GO:0042450,GO:0043436,GO:0043603,GO:0043604,GO:0043857,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046394,GO:0071704,GO:0071941,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.3.9	ko:K09065	ko00220,ko01100,ko01230,map00220,map01100,map01230	M00845	R07245	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_2037976_8	518766.Rmar_0947	4.807e-112	374.0	COG4992@1|root,COG4992@2|Bacteria,4NE0Z@976|Bacteroidetes,1FJWU@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_2037976_27	1499680.CCFE01000033_gene3976	2.513e-46	172.0	COG0073@1|root,COG0073@2|Bacteria,1VGDC@1239|Firmicutes	1239|Firmicutes	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
HKD1_k127_2037976_14	573061.Clocel_4046	6.273e-83	289.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia,36E3S@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_2037976_18	215803.DB30_7506	1.916e-67	244.0	COG0132@1|root,COG0132@2|Bacteria,1MYAE@1224|Proteobacteria,438QP@68525|delta/epsilon subdivisions,2X92A@28221|Deltaproteobacteria,2YXIK@29|Myxococcales	28221|Deltaproteobacteria	H	Domain of unknown function (DUF1611_C) P-loop domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611
HKD1_k127_2037976_3	1123371.ATXH01000003_gene1979	1.001e-180	572.0	COG0137@1|root,COG0137@2|Bacteria,2GGZY@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_2037976_39	1458462.JNLK01000001_gene2176	2.759e-20	95.0	COG1438@1|root,COG1438@2|Bacteria,1V1R7@1239|Firmicutes,24HGQ@186801|Clostridia,27MP8@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Regulates arginine biosynthesis genes	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HKD1_k127_2037976_4	370438.PTH_0517	1.513e-156	508.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,260K5@186807|Peptococcaceae	186801|Clostridia	E	TIGRFAM argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_2037976_0	1519464.HY22_09715	4.146e-293	920.0	COG1505@1|root,COG1505@2|Bacteria	2|Bacteria	E	serine-type exopeptidase activity	pep	GO:0005575,GO:0005623,GO:0042597,GO:0044464	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD1_k127_2037976_15	379066.GAU_1080	8.723e-81	279.0	COG1234@1|root,COG1234@2|Bacteria,1ZUWE@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_2037976_40	1047013.AQSP01000112_gene389	1.297e-17	94.0	COG1596@1|root,COG1596@2|Bacteria,2NPNM@2323|unclassified Bacteria	2|Bacteria	M	Polysaccharide export protein	-	-	-	ko:K01991,ko:K20988	ko02026,ko05111,map02026,map05111	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_2037976_16	7370.XP_005188234.1	4.091e-80	274.0	COG1028@1|root,KOG0725@2759|Eukaryota,38BUC@33154|Opisthokonta,3BC34@33208|Metazoa,3D09G@33213|Bilateria,41TU2@6656|Arthropoda,3SZ4C@50557|Insecta,454Z1@7147|Diptera	33208|Metazoa	Q	Oxidoreductase activity. It is involved in the biological process described with metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_2037976_50	1037409.BJ6T_37450	5.253e-05	56.0	COG2114@1|root,COG3899@1|root,COG2114@2|Bacteria,COG3899@2|Bacteria,1MUDT@1224|Proteobacteria,2TQVN@28211|Alphaproteobacteria,3JTD5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	AAA ATPase domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,DZR,Guanylate_cyc,TPR_12
HKD1_k127_2037976_13	42256.RradSPS_0832	4.142e-84	293.0	COG2339@1|root,COG2339@2|Bacteria,2GKR5@201174|Actinobacteria,4CU00@84995|Rubrobacteria	84995|Rubrobacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD1_k127_2037976_21	886293.Sinac_3059	9.785e-56	204.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11,3.1.4.17	ko:K00784,ko:K01120	ko00230,ko03013,map00230,map03013	-	R00191,R01234	RC00296	ko00000,ko00001,ko01000,ko03016	-	-	-	GAF,HD_5,Lactamase_B_2,PDEase_II
HKD1_k127_2037976_32	886293.Sinac_1403	1.041e-28	119.0	COG1146@1|root,COG1146@2|Bacteria,2J013@203682|Planctomycetes	203682|Planctomycetes	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
HKD1_k127_2037976_29	760192.Halhy_4503	4.018e-36	143.0	COG2318@1|root,COG2318@2|Bacteria,4NQEI@976|Bacteroidetes	976|Bacteroidetes	S	Protein of unknown function (DUF1572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1572
HKD1_k127_2037976_20	1499967.BAYZ01000039_gene2222	3.71e-56	205.0	COG0558@1|root,COG0558@2|Bacteria,2NPXW@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.34	ko:K07291	ko00562,map00562	-	R09670	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_2037976_34	240015.ACP_2938	5.867e-26	109.0	2BYAI@1|root,315Y9@2|Bacteria,3Y52S@57723|Acidobacteria,2JJJK@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2037976_52	1088869.GMO_15680	0.0007563	48.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2JPZV@204441|Rhodospirillales	204441|Rhodospirillales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2037976_37	330214.NIDE2908	1.83e-22	100.0	COG3536@1|root,COG3536@2|Bacteria,3J1AV@40117|Nitrospirae	40117|Nitrospirae	S	Protein of unknown function (DUF971)	-	-	-	-	-	-	-	-	-	-	-	-	DUF971
HKD1_k127_2037976_44	646529.Desaci_2397	2.089e-11	68.0	COG3118@1|root,COG3118@2|Bacteria,1VEPC@1239|Firmicutes,24UN5@186801|Clostridia	186801|Clostridia	O	TIGRFAM bacillithiol system protein YtxJ	-	-	-	-	-	-	-	-	-	-	-	-	DUF2847
HKD1_k127_2037976_41	666509.RCA23_c04090	1.81e-17	98.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
HKD1_k127_2037976_35	1380391.JIAS01000018_gene950	3.301e-24	120.0	COG0457@1|root,COG4249@1|root,COG4785@1|root,COG0457@2|Bacteria,COG4249@2|Bacteria,COG4785@2|Bacteria,1R3WZ@1224|Proteobacteria,2TUBK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	protein containing caspase domain	MA20_02090	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HKD1_k127_2037976_24	1254432.SCE1572_07800	6.768e-53	208.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_2037976_2	1170562.Cal6303_2739	6.704e-209	689.0	COG0520@1|root,COG1672@1|root,COG2319@1|root,COG0520@2|Bacteria,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HINJ@1161|Nostocales	1117|Cyanobacteria	L	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,WD40
HKD1_k127_2037976_36	234267.Acid_1618	5.472e-24	114.0	COG4916@1|root,COG4916@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_2037976_47	397288.C806_02841	1.222e-07	63.0	COG3863@1|root,COG3863@2|Bacteria,1VESN@1239|Firmicutes,24E63@186801|Clostridia	186801|Clostridia	S	PFAM Orthopoxvirus protein of	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C92
HKD1_k127_2037976_9	1173027.Mic7113_5049	7.084e-97	351.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H8D7@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_1,TPR_10,TPR_12,TPR_7,TPR_8
HKD1_k127_2037976_43	234267.Acid_5978	4.587e-13	79.0	2EU62@1|root,33MNN@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4384
HKD1_k127_2037976_22	290397.Adeh_0115	1.741e-54	214.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2X566@28221|Deltaproteobacteria,2Z063@29|Myxococcales	28221|Deltaproteobacteria	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_2063873_2	1123073.KB899241_gene2746	3.177e-80	283.0	COG5563@1|root,COG5563@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2063873_1	266117.Rxyl_0136	1.709e-103	355.0	COG1167@1|root,COG1167@2|Bacteria,2GJ5P@201174|Actinobacteria,4CQ4C@84995|Rubrobacteria	84995|Rubrobacteria	K	aminotransferase class I and II	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD1_k127_2063873_3	452637.Oter_0661	1.304e-52	189.0	29XGP@1|root,30J79@2|Bacteria,46XI5@74201|Verrucomicrobia,3K9V9@414999|Opitutae	414999|Opitutae	S	Domain of unknown function (DUF5069)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5069
HKD1_k127_2063873_0	1227457.C451_12270	6.507e-165	532.0	COG2041@1|root,arCOG00266@2157|Archaea,2Y7J0@28890|Euryarchaeota,240T4@183963|Halobacteria	183963|Halobacteria	S	COG4117 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein)	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB,Oxidored_molyb
HKD1_k127_2063873_4	1444711.CCJF01000005_gene1450	6.043e-29	119.0	2E4EA@1|root,32Z9I@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2063873_5	1122243.KB903796_gene1682	1.217e-07	55.0	2DMHR@1|root,32RMI@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_20866_27	318996.AXAZ01000090_gene5783	9.659e-05	51.0	2AJCC@1|root,319XP@2|Bacteria,1NUQI@1224|Proteobacteria,2URSP@28211|Alphaproteobacteria,3K3ZM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_20866_19	1173025.GEI7407_2899	1.48e-36	154.0	COG1233@1|root,COG1233@2|Bacteria,1G086@1117|Cyanobacteria,1H92F@1150|Oscillatoriales	1117|Cyanobacteria	Q	C-3'',4'' desaturase CrtD	crtD	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD1_k127_20866_22	221359.RS9916_27159	2.894e-10	71.0	COG1266@1|root,COG1266@2|Bacteria,1G0ZJ@1117|Cyanobacteria,1GZ8P@1129|Synechococcus	1117|Cyanobacteria	S	metal-dependent membrane protease	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_20866_10	290397.Adeh_0688	4.394e-93	332.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YUJU@29|Myxococcales	28221|Deltaproteobacteria	T	response regulator	-	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_20866_21	56780.SYN_00405	2.092e-18	90.0	COG2331@1|root,COG2331@2|Bacteria,1N6Q9@1224|Proteobacteria,42V24@68525|delta/epsilon subdivisions,2WR87@28221|Deltaproteobacteria,2MSGF@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Putative regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Zn-ribbon_8
HKD1_k127_20866_29	682795.AciX8_4282	0.0002712	53.0	COG2304@1|root,COG2304@2|Bacteria,3Y72K@57723|Acidobacteria,2JK9W@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA_2
HKD1_k127_20866_18	926550.CLDAP_25090	1.524e-39	153.0	COG0454@1|root,COG0456@2|Bacteria,2G95N@200795|Chloroflexi	200795|Chloroflexi	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD1_k127_20866_7	1163617.SCD_n00323	1.006e-111	370.0	COG1052@1|root,COG1052@2|Bacteria,1MU2D@1224|Proteobacteria,2WGFK@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	hprA	-	1.1.1.29,1.1.1.399,1.1.1.95	ko:K00018,ko:K00058	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020,M00346	R00717,R01388,R01513	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_20866_6	448385.sce7696	4.357e-122	406.0	COG1404@1|root,COG1404@2|Bacteria,1PEJJ@1224|Proteobacteria,438RE@68525|delta/epsilon subdivisions,2X3YD@28221|Deltaproteobacteria,2YXKA@29|Myxococcales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_20866_11	204669.Acid345_4094	2.471e-81	278.0	COG1834@1|root,COG1834@2|Bacteria,3Y86C@57723|Acidobacteria	57723|Acidobacteria	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
HKD1_k127_20866_0	483219.LILAB_19140	0.0	1045.0	COG0339@1|root,COG0339@2|Bacteria,1MU1K@1224|Proteobacteria,42MUY@68525|delta/epsilon subdivisions,2X6WF@28221|Deltaproteobacteria,2YWNJ@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase family M3	dcp	-	3.4.15.5	ko:K01284	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3
HKD1_k127_20866_17	1335760.ASTG01000005_gene981	1.769e-45	172.0	2ADQJ@1|root,313FX@2|Bacteria,1MYNR@1224|Proteobacteria,2UCQS@28211|Alphaproteobacteria,2K5ZN@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_20866_15	204669.Acid345_0779	4.187e-59	213.0	COG1793@1|root,COG1793@2|Bacteria,3Y2VV@57723|Acidobacteria,2JIJ7@204432|Acidobacteriia	204432|Acidobacteriia	L	DNA ligase D, 3'-phosphoesterase domain	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_20866_8	378806.STAUR_3299	1.936e-109	361.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,42REG@68525|delta/epsilon subdivisions,2WNK2@28221|Deltaproteobacteria,2YXI1@29|Myxococcales	28221|Deltaproteobacteria	L	Ribonuclease HII	rnhB	GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006281,GO:0006298,GO:0006401,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0032299,GO:0032991,GO:0033554,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044464,GO:0046483,GO:0046700,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901361,GO:1901575,GO:1901576	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DUF208,RNase_HII
HKD1_k127_20866_24	502025.Hoch_2178	2.744e-07	63.0	COG1807@1|root,COG1807@2|Bacteria,1QX93@1224|Proteobacteria,43C25@68525|delta/epsilon subdivisions,2X7CQ@28221|Deltaproteobacteria,2YUUE@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_20866_9	909663.KI867150_gene2720	2.892e-108	364.0	COG0535@1|root,COG0535@2|Bacteria,1Q6NI@1224|Proteobacteria,433FI@68525|delta/epsilon subdivisions,2WXJT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_20866_14	864702.OsccyDRAFT_0072	1.663e-69	249.0	COG5263@1|root,COG5263@2|Bacteria,1G1AI@1117|Cyanobacteria,1HASA@1150|Oscillatoriales	1117|Cyanobacteria	S	KWG Leptospira	-	-	-	-	-	-	-	-	-	-	-	-	SLH,WG_beta_rep
HKD1_k127_20866_13	211165.AJLN01000153_gene671	1.428e-73	254.0	COG0500@1|root,COG2226@2|Bacteria,1GAXU@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_20866_3	502025.Hoch_5176	3.111e-197	635.0	COG1228@1|root,COG1228@2|Bacteria,1MY4V@1224|Proteobacteria,4383R@68525|delta/epsilon subdivisions,2X3DQ@28221|Deltaproteobacteria,2YVM1@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_20866_5	234267.Acid_1490	3.196e-159	522.0	COG3276@1|root,COG3276@2|Bacteria,3Y6R2@57723|Acidobacteria	57723|Acidobacteria	J	Elongation factor SelB, winged helix	-	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD1_k127_20866_30	1227497.C491_21961	0.0003393	47.0	COG0607@1|root,arCOG02021@2157|Archaea,2XZ3E@28890|Euryarchaeota,23WP8@183963|Halobacteria	183963|Halobacteria	P	COG0607 Rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_20866_26	1210908.HSB1_04810	2.022e-06	59.0	COG0589@1|root,arCOG02053@2157|Archaea,2XXRS@28890|Euryarchaeota,23W7D@183963|Halobacteria	183963|Halobacteria	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_20866_20	247490.KSU1_C0334	7.946e-21	104.0	COG0589@1|root,COG0589@2|Bacteria,2J042@203682|Planctomycetes	203682|Planctomycetes	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_20866_28	1499967.BAYZ01000186_gene3950	0.0001967	53.0	2EJQZ@1|root,33DFT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_20866_2	575540.Isop_3575	8.227e-225	710.0	COG0531@1|root,COG0531@2|Bacteria,2IXT5@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_20866_4	204669.Acid345_1271	4.521e-165	534.0	COG1233@1|root,COG1233@2|Bacteria,3Y3I8@57723|Acidobacteria,2JI78@204432|Acidobacteriia	204432|Acidobacteriia	C	TIGRFAM phytoene desaturase	-	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD1_k127_20866_1	204669.Acid345_1270	8.205e-293	904.0	COG1233@1|root,COG1233@2|Bacteria,3Y3T3@57723|Acidobacteria,2JME5@204432|Acidobacteriia	204432|Acidobacteriia	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_8
HKD1_k127_20866_16	886293.Sinac_2431	5.561e-56	200.0	COG2318@1|root,COG2318@2|Bacteria,2IZP2@203682|Planctomycetes	203682|Planctomycetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB,DinB_2
HKD1_k127_20866_12	1278073.MYSTI_04861	2.727e-79	278.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,42MMY@68525|delta/epsilon subdivisions,2WIXA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15,2.7.6.3	ko:K00796,ko:K13941	ko00790,ko01100,map00790,map01100	M00126,M00840,M00841	R03066,R03067,R03503	RC00002,RC00017,RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_20866_25	1403313.AXBR01000014_gene2203	1.771e-06	49.0	2EG8N@1|root,33A0G@2|Bacteria,1VMHK@1239|Firmicutes,4HSIH@91061|Bacilli,1ZJWT@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2129840_15	1267535.KB906767_gene4678	2.545e-74	263.0	COG1092@1|root,COG1092@2|Bacteria,3Y2PV@57723|Acidobacteria,2JICM@204432|Acidobacteriia	204432|Acidobacteriia	J	S-adenosylmethionine-dependent methyltransferase	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD1_k127_2129840_4	234267.Acid_1644	1.575e-201	665.0	COG1629@1|root,COG4771@2|Bacteria,3Y7B4@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_2129840_23	926566.Terro_0858	1.103e-38	161.0	COG0250@1|root,COG0250@2|Bacteria,3Y3I1@57723|Acidobacteria,2JHYX@204432|Acidobacteriia	204432|Acidobacteriia	K	Participates in transcription elongation, termination and antitermination	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2129840_35	671143.DAMO_3157	6.352e-11	68.0	28VYX@1|root,2ZI05@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2129840_29	338966.Ppro_2663	1.836e-27	120.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42W7K@68525|delta/epsilon subdivisions,2WRU7@28221|Deltaproteobacteria,43VUJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_2129840_22	379066.GAU_2442	1.32e-40	157.0	COG1595@1|root,COG1595@2|Bacteria,1ZT3B@142182|Gemmatimonadetes	142182|Gemmatimonadetes	K	ECF sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_2129840_27	204669.Acid345_1999	4.017e-30	124.0	COG2165@1|root,COG2165@2|Bacteria,3Y4ZX@57723|Acidobacteria,2JJN5@204432|Acidobacteriia	204432|Acidobacteriia	U	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD1_k127_2129840_30	926566.Terro_1443	2.285e-26	119.0	COG2165@1|root,COG2165@2|Bacteria,3Y4RJ@57723|Acidobacteria,2JJB4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl
HKD1_k127_2129840_20	1267534.KB906756_gene158	8.835e-42	178.0	COG4796@1|root,COG4796@2|Bacteria,3Y2G2@57723|Acidobacteria,2JHZH@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the GSP D family	-	-	-	ko:K02453	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	Cohesin,Secretin,Secretin_N
HKD1_k127_2129840_1	682795.AciX8_0665	1.589e-217	691.0	COG2804@1|root,COG2804@2|Bacteria,3Y3GB@57723|Acidobacteria,2JHVF@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system protein E	-	-	-	ko:K02652	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE,T2SSE_N
HKD1_k127_2129840_13	278963.ATWD01000001_gene4226	2.168e-80	283.0	COG1459@1|root,COG1459@2|Bacteria,3Y2X8@57723|Acidobacteria,2JHIX@204432|Acidobacteriia	204432|Acidobacteriia	NU	PFAM Type II secretion system F domain	-	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD1_k127_2129840_3	886293.Sinac_0988	1.657e-212	670.0	COG0531@1|root,COG0531@2|Bacteria,2IX7G@203682|Planctomycetes	203682|Planctomycetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_2129840_33	861299.J421_1409	1.577e-18	94.0	2EV6U@1|root,33NMK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2129840_21	861299.J421_1407	1.248e-41	160.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_2129840_7	266117.Rxyl_3166	1.999e-148	489.0	COG0749@1|root,COG0749@2|Bacteria,2GJY2@201174|Actinobacteria,4CP7C@84995|Rubrobacteria	84995|Rubrobacteria	L	DNA polymerase	-	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_pol_A,DNA_pol_A_exo1
HKD1_k127_2129840_34	749222.Nitsa_1123	3.013e-16	85.0	COG1917@1|root,COG1917@2|Bacteria,1Q5S1@1224|Proteobacteria,432IR@68525|delta/epsilon subdivisions,2YSTP@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2129840_25	459495.SPLC1_S501130	1.081e-36	143.0	COG0780@1|root,COG0780@2|Bacteria,1G5W6@1117|Cyanobacteria,1HB47@1150|Oscillatoriales	1117|Cyanobacteria	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD1_k127_2129840_11	743722.Sph21_3230	4.663e-88	297.0	COG0705@1|root,COG0705@2|Bacteria,4NJG9@976|Bacteroidetes,1J16X@117747|Sphingobacteriia	976|Bacteroidetes	S	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_2129840_10	234267.Acid_1117	1.16e-127	426.0	COG1301@1|root,COG1301@2|Bacteria,3Y2G6@57723|Acidobacteria	57723|Acidobacteria	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	ko:K03309,ko:K11102	-	-	-	-	ko00000,ko02000	2.A.23,2.A.23.1.1,2.A.23.1.2	-	-	SDF
HKD1_k127_2129840_12	1499967.BAYZ01000065_gene6109	5.81e-85	291.0	COG0061@1|root,COG0061@2|Bacteria,2NP7T@2323|unclassified Bacteria	2|Bacteria	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	GO:0000166,GO:0003674,GO:0003824,GO:0003951,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006739,GO:0006741,GO:0006753,GO:0006766,GO:0006767,GO:0006769,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008976,GO:0009058,GO:0009108,GO:0009117,GO:0009165,GO:0009820,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016776,GO:0017076,GO:0017144,GO:0018130,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0043603,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046496,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0051287,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:0097159,GO:0097367,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iEcSMS35_1347.EcSMS35_2767,iHN637.CLJU_RS05480,iLJ478.TM1733,iSB619.SA_RS04895	NAD_kinase
HKD1_k127_2129840_14	338966.Ppro_1155	6.778e-80	274.0	COG0537@1|root,COG1189@1|root,COG0537@2|Bacteria,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,42R2J@68525|delta/epsilon subdivisions,2WIJ6@28221|Deltaproteobacteria,43S7C@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	ribosomal RNA methyltransferase RrmJ FtsJ	tlyA	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD1_k127_2129840_2	1121430.JMLG01000003_gene556	9.719e-217	692.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,2604R@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_2129840_18	1246484.D479_00720	4.991e-61	214.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,4HGYP@91061|Bacilli	91061|Bacilli	M	Sortase and related acyltransferases	pat	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_4
HKD1_k127_2129840_26	401053.AciPR4_2691	4.016e-32	129.0	COG0640@1|root,COG0640@2|Bacteria,3Y7J1@57723|Acidobacteria,2JMRU@204432|Acidobacteriia	204432|Acidobacteriia	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_2129840_9	1267535.KB906767_gene1145	1.206e-139	460.0	COG0008@1|root,COG0008@2|Bacteria,3Y465@57723|Acidobacteria,2JHZW@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_2129840_36	1280952.HJA_12830	1.245e-09	67.0	COG4319@1|root,COG4319@2|Bacteria,1RDBF@1224|Proteobacteria,2U7AM@28211|Alphaproteobacteria,43Y3X@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_2129840_19	278963.ATWD01000002_gene781	2.391e-49	198.0	COG1807@1|root,COG1807@2|Bacteria,3Y3EH@57723|Acidobacteria,2JHRT@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_2129840_0	1163407.UU7_03772	0.0	1176.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,1RMS4@1236|Gammaproteobacteria,1X351@135614|Xanthomonadales	135614|Xanthomonadales	M	in Yersinia the HmsR protein is an inner membrane protein	hmsR	-	-	ko:K11936	ko02026,map02026	-	-	-	ko00000,ko00001,ko01000,ko01003,ko02000	4.D.1.1.2,4.D.1.1.3	GT2	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
HKD1_k127_2129840_5	1382359.JIAL01000001_gene2085	6.381e-161	518.0	COG1228@1|root,COG1228@2|Bacteria,3Y3BK@57723|Acidobacteria,2JKVY@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_2129840_8	861299.J421_1133	1.863e-141	463.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	gadC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	iEC042_1314.EC042_1624	AA_permease_2
HKD1_k127_2129840_24	314254.OA2633_04066	7.452e-37	143.0	COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,2UK7M@28211|Alphaproteobacteria,440N5@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
HKD1_k127_2129840_17	870187.Thini_3117	3.862e-62	222.0	COG3738@1|root,COG3738@2|Bacteria,1RE1M@1224|Proteobacteria,1S44B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein conserved in bacteria	yijF	-	-	ko:K09974	-	-	-	-	ko00000	-	-	-	DUF1287
HKD1_k127_2129840_28	649638.Trad_1357	1.047e-27	122.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	PE-PPE,VKG_Carbox
HKD1_k127_2129840_31	1267535.KB906767_gene4256	7.394e-24	106.0	COG0718@1|root,COG0718@2|Bacteria,3Y5CB@57723|Acidobacteria	57723|Acidobacteria	L	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD1_k127_2129840_16	204669.Acid345_1973	2.416e-73	252.0	COG0353@1|root,COG0353@2|Bacteria,3Y31E@57723|Acidobacteria,2JHQM@204432|Acidobacteriia	204432|Acidobacteriia	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HKD1_k127_2129840_32	1303518.CCALI_02309	3.478e-19	89.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	clcA_1	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD1_k127_2129840_6	1121468.AUBR01000038_gene1965	9.732e-158	509.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1TR8J@1239|Firmicutes,247RR@186801|Clostridia,42HW6@68295|Thermoanaerobacterales	186801|Clostridia	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD1_k127_2155290_10	497964.CfE428DRAFT_0882	6.946e-26	110.0	COG0763@1|root,COG0763@2|Bacteria,46SSG@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxB	-	2.4.1.182	ko:K00748	ko00540,ko01100,map00540,map01100	M00060	R04606	RC00005,RC00059	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT19	-	LpxB
HKD1_k127_2155290_5	171693.BN988_02979	1.464e-56	204.0	COG1878@1|root,COG1878@2|Bacteria,1U801@1239|Firmicutes,4HDQ3@91061|Bacilli,23NE9@182709|Oceanobacillus	91061|Bacilli	S	Putative cyclase	kynB	GO:0003674,GO:0003824,GO:0004061,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008270,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016054,GO:0016787,GO:0016810,GO:0016811,GO:0019439,GO:0019441,GO:0019752,GO:0032787,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043167,GO:0043169,GO:0043420,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046872,GO:0046914,GO:0070189,GO:0071704,GO:1901360,GO:1901361,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	3.5.1.9	ko:K07130	ko00380,ko00630,ko01100,map00380,map00630,map01100	M00038	R00988,R01959,R04911	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	Cyclase
HKD1_k127_2155290_13	1211114.ALIP01000139_gene2141	4.227e-16	92.0	COG1807@1|root,COG1807@2|Bacteria,1MXH5@1224|Proteobacteria,1RSQE@1236|Gammaproteobacteria,1X589@135614|Xanthomonadales	135614|Xanthomonadales	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT_2
HKD1_k127_2155290_8	1122604.JONR01000034_gene418	3.02e-37	145.0	295V1@1|root,2ZT62@2|Bacteria,1P75A@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2155290_12	1379270.AUXF01000001_gene1923	6.487e-17	91.0	2DF5Q@1|root,2ZQK3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2155290_15	871968.DESME_13310	1.974e-14	83.0	2DG6B@1|root,2ZUQ3@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2155290_3	375286.mma_0137	5.231e-71	244.0	COG1225@1|root,COG1225@2|Bacteria,1MWJP@1224|Proteobacteria,2VQ0B@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Redoxin	bcpB	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD1_k127_2155290_2	936455.KI421499_gene1991	1.515e-72	261.0	COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,2U35E@28211|Alphaproteobacteria,3JWCA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	Beta-lactamase	ampC	-	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase
HKD1_k127_2155290_7	335543.Sfum_3099	3.151e-40	154.0	2E69N@1|root,330XJ@2|Bacteria,1NM8X@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2155290_4	497964.CfE428DRAFT_0883	1.179e-61	216.0	COG0537@1|root,COG0537@2|Bacteria,46T23@74201|Verrucomicrobia	74201|Verrucomicrobia	FG	PFAM histidine triad (HIT) protein	-	-	2.7.7.53	ko:K19710	ko00230,map00230	-	R00126,R01618	RC00002,RC02753,RC02795	ko00000,ko00001,ko01000	-	-	-	HIT
HKD1_k127_2155290_17	243090.RB7149	8.364e-08	62.0	COG3468@1|root,COG3468@2|Bacteria,2J1BR@203682|Planctomycetes	203682|Planctomycetes	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2155290_1	497964.CfE428DRAFT_5482	5.188e-88	311.0	2FEQM@1|root,346PU@2|Bacteria,46W7F@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2155290_9	517418.Ctha_2687	7.992e-29	119.0	COG0316@1|root,COG0316@2|Bacteria,1FF80@1090|Chlorobi	1090|Chlorobi	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD1_k127_2155290_0	497964.CfE428DRAFT_5484	7.97e-242	761.0	COG0323@1|root,COG0323@2|Bacteria,46SG5@74201|Verrucomicrobia	74201|Verrucomicrobia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_2155290_14	1183438.GKIL_0413	1.554e-14	79.0	COG2911@1|root,COG5295@1|root,COG2911@2|Bacteria,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	GO:0005575,GO:0005576	-	-	-	-	-	-	-	-	-	-	CBM_3,CHAT,CHU_C,Cohesin,Peptidase_S74
HKD1_k127_2173340_30	1267535.KB906767_gene3275	1.46e-12	76.0	COG0457@1|root,COG0457@2|Bacteria,3Y7UM@57723|Acidobacteria,2JNRM@204432|Acidobacteriia	204432|Acidobacteriia	S	TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2173340_25	234267.Acid_3898	1.525e-25	124.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria	2|Bacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,VWA,VWA_2
HKD1_k127_2173340_14	234267.Acid_3494	1.653e-90	313.0	COG0457@1|root,COG0457@2|Bacteria,3Y6B2@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_2173340_19	234267.Acid_3491	5.403e-66	243.0	COG0457@1|root,COG0457@2|Bacteria,3Y8AI@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_2173340_13	1267535.KB906767_gene4411	3.522e-97	331.0	COG0457@1|root,COG0457@2|Bacteria,3Y75D@57723|Acidobacteria,2JKA7@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554
HKD1_k127_2173340_6	1267534.KB906754_gene2895	2.613e-223	704.0	COG0457@1|root,COG0457@2|Bacteria,3Y3WM@57723|Acidobacteria,2JI36@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HKD1_k127_2173340_3	1408473.JHXO01000008_gene2711	7.306e-301	940.0	COG1472@1|root,COG1472@2|Bacteria,4NEBU@976|Bacteroidetes,2FN0J@200643|Bacteroidia	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_2173340_7	1382306.JNIM01000001_gene2361	6.668e-199	643.0	COG1472@1|root,COG1472@2|Bacteria,2G639@200795|Chloroflexi	200795|Chloroflexi	G	Belongs to the glycosyl hydrolase 3 family	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HKD1_k127_2173340_8	661478.OP10G_4440	2.886e-197	636.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_2_N,SASA
HKD1_k127_2173340_5	215803.DB30_3103	4.026e-245	779.0	COG3525@1|root,COG3525@2|Bacteria,1MVDE@1224|Proteobacteria,42YD5@68525|delta/epsilon subdivisions,2X313@28221|Deltaproteobacteria,2YTXH@29|Myxococcales	28221|Deltaproteobacteria	G	Putative carbohydrate binding domain	-	-	3.2.1.52	ko:K12373	ko00511,ko00513,ko00520,ko00531,ko00603,ko00604,ko01100,ko04142,map00511,map00513,map00520,map00531,map00603,map00604,map01100,map04142	M00079	R00022,R06004,R11316	RC00049	ko00000,ko00001,ko00002,ko01000,ko03110	-	GH20	-	CHB_HEX,CHB_HEX_C,Glyco_hydro_20,Glyco_hydro_20b
HKD1_k127_2173340_4	945713.IALB_2579	2.627e-256	814.0	COG1472@1|root,COG1472@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 3 family	bglX	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0008422,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015926,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_2173340_12	266117.Rxyl_2476	2.885e-124	411.0	COG2271@1|root,COG2271@2|Bacteria,2GIS1@201174|Actinobacteria	201174|Actinobacteria	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_2173340_10	1123242.JH636435_gene1109	5.549e-142	458.0	COG3386@1|root,COG3386@2|Bacteria,2IXZT@203682|Planctomycetes	203682|Planctomycetes	G	gluconolactonase	-	-	-	-	-	-	-	-	-	-	-	-	SGL
HKD1_k127_2173340_24	204669.Acid345_1693	5.988e-30	125.0	2E81U@1|root,332FW@2|Bacteria,3Y5IC@57723|Acidobacteria,2JJWT@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2173340_11	452637.Oter_2944	3.696e-139	449.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	-	-	-	-	-	-	-	-	-	-	CN_hydrolase
HKD1_k127_2173340_29	1382359.JIAL01000001_gene323	1.109e-12	73.0	COG2010@1|root,COG2010@2|Bacteria,3Y5MU@57723|Acidobacteria,2JJWK@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_2173340_18	665952.HMPREF1015_00265	3.952e-67	241.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,4HBAU@91061|Bacilli,1ZBV8@1386|Bacillus	91061|Bacilli	G	Glucokinase	glcK	GO:0003674,GO:0003824,GO:0004340,GO:0004396,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019200,GO:0019637,GO:0044237,GO:0044238,GO:0044262,GO:0044424,GO:0044464,GO:0046835,GO:0051156,GO:0071704,GO:1901135	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS07790	ROK
HKD1_k127_2173340_22	204669.Acid345_3237	1.369e-37	142.0	2EQP8@1|root,33I96@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2173340_23	204669.Acid345_3238	1.022e-30	123.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	MA20_26500	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD1_k127_2173340_16	713586.KB900536_gene2802	2.095e-76	268.0	COG0265@1|root,COG0265@2|Bacteria,1R6MU@1224|Proteobacteria,1S181@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Trypsin-like serine protease	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_2173340_21	671143.DAMO_1116	1.389e-41	166.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD1_k127_2173340_1	1163617.SCD_n00706	0.0	1098.0	COG0058@1|root,COG0058@2|Bacteria,1MW4J@1224|Proteobacteria,2VM4W@28216|Betaproteobacteria	28216|Betaproteobacteria	G	alpha-glucan phosphorylase	-	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_2173340_2	338966.Ppro_0419	1.81e-312	970.0	COG1523@1|root,COG1523@2|Bacteria,1MU19@1224|Proteobacteria,42P3J@68525|delta/epsilon subdivisions,2WKFS@28221|Deltaproteobacteria,43U1C@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	Belongs to the glycosyl hydrolase 13 family	-	-	3.2.1.68	ko:K01214	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R09995,R11261	-	ko00000,ko00001,ko00002,ko01000	-	CBM48,GH13	-	Alpha-amylase,CBM_48
HKD1_k127_2173340_33	234267.Acid_5808	0.0005016	42.0	COG0176@1|root,COG0176@2|Bacteria,3Y6V9@57723|Acidobacteria	57723|Acidobacteria	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_2173340_9	1267535.KB906767_gene3716	4.983e-193	616.0	COG3604@1|root,COG3604@2|Bacteria,3Y9A3@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,GAF_3,HTH_8,Sigma54_activat
HKD1_k127_2173340_15	1267533.KB906735_gene4603	4.141e-82	290.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_2173340_17	1267534.KB906760_gene1325	1.763e-71	259.0	COG0845@1|root,COG0845@2|Bacteria,3Y8NI@57723|Acidobacteria	57723|Acidobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_2173340_0	1278073.MYSTI_03564	0.0	1275.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MQ0@68525|delta/epsilon subdivisions,2WJ2A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_2178128_6	929506.CbC4_1324	1.754e-22	101.0	COG2337@1|root,COG2337@2|Bacteria,1VGVY@1239|Firmicutes,25DFK@186801|Clostridia,36N8P@31979|Clostridiaceae	186801|Clostridia	T	PemK-like, MazF-like toxin of type II toxin-antitoxin system	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_2178128_4	1122604.JONR01000008_gene2129	3.221e-46	179.0	COG1266@1|root,COG1266@2|Bacteria,1NXKQ@1224|Proteobacteria	1224|Proteobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_2178128_1	82995.CR62_03715	5.167e-185	591.0	COG3104@1|root,COG3104@2|Bacteria,1QXBE@1224|Proteobacteria,1RNVV@1236|Gammaproteobacteria,401XX@613|Serratia	1236|Gammaproteobacteria	E	amino acid peptide transporter	ydgR	-	-	ko:K03305,ko:K06218	-	-	-	-	ko00000,ko02048	2.A.17	-	-	MFS_1,PTR2
HKD1_k127_2178128_0	497964.CfE428DRAFT_6595	3.18e-320	992.0	COG0480@1|root,COG0480@2|Bacteria	2|Bacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA2	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006790,GO:0008150,GO:0008152,GO:0009987,GO:0016020,GO:0030312,GO:0044237,GO:0044464,GO:0071944	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_2178128_5	1120965.AUBV01000006_gene2184	9.149e-39	152.0	28H8R@1|root,2Z7KJ@2|Bacteria,4NGZN@976|Bacteroidetes,47NH9@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2178128_3	483219.LILAB_27650	1.215e-55	209.0	COG2374@1|root,COG2374@2|Bacteria,1RA34@1224|Proteobacteria,42XZM@68525|delta/epsilon subdivisions,2WT9C@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF3616)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3616
HKD1_k127_2178128_7	583355.Caka_1871	3.362e-18	89.0	2ERKQ@1|root,33J67@2|Bacteria,46WN1@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2178128_10	1449049.JONW01000005_gene1996	2.278e-05	48.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,2KI57@204458|Caulobacterales	204458|Caulobacterales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_2178128_2	1366050.N234_10140	2.993e-61	227.0	COG1680@1|root,COG2815@1|root,COG1680@2|Bacteria,COG2815@2|Bacteria,1RIP7@1224|Proteobacteria,2W73Q@28216|Betaproteobacteria,1KDQJ@119060|Burkholderiaceae	28216|Betaproteobacteria	V	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_2178128_8	1192034.CAP_8755	1.738e-10	67.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,42UCT@68525|delta/epsilon subdivisions,2WPAW@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_2178128_9	497964.CfE428DRAFT_4858	1.484e-08	57.0	COG0724@1|root,COG0724@2|Bacteria,46VMU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM RNP-1 like RNA-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_2232751_6	1267533.KB906733_gene3481	1.441e-47	171.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_2232751_1	1121127.JAFA01000046_gene6827	1.068e-192	608.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2VZP3@28216|Betaproteobacteria,1KHJR@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Epoxide hydrolase N terminus	-	-	-	-	-	-	-	-	-	-	-	-	EHN
HKD1_k127_2232751_5	1267534.KB906758_gene2365	4.858e-66	230.0	2DKVG@1|root,30GRY@2|Bacteria,3Y4H8@57723|Acidobacteria,2JJAT@204432|Acidobacteriia	204432|Acidobacteriia	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
HKD1_k127_2232751_0	420324.KI911965_gene933	6.033e-215	677.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TU0K@28211|Alphaproteobacteria,1JU2N@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	-	-	1.16.1.1	ko:K00520	-	-	-	-	ko00000,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_2232751_2	404589.Anae109_1057	5.602e-109	357.0	COG0346@1|root,COG0346@2|Bacteria,1MV4D@1224|Proteobacteria	1224|Proteobacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_2232751_9	1500304.JQKY01000010_gene5407	3.624e-34	133.0	COG1418@1|root,COG1418@2|Bacteria,1MV0J@1224|Proteobacteria,2TVFS@28211|Alphaproteobacteria,4BCKI@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_2232751_10	366394.Smed_5523	3.399e-28	119.0	COG4566@1|root,COG4566@2|Bacteria,1N460@1224|Proteobacteria,2UD2Q@28211|Alphaproteobacteria,4BJNR@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_2232751_4	1403819.BATR01000184_gene6387	7.298e-69	239.0	COG4566@1|root,COG4566@2|Bacteria,46WZ8@74201|Verrucomicrobia,2IVU6@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_2232751_3	443598.AUFA01000053_gene739	1.334e-89	321.0	COG0515@1|root,COG2202@1|root,COG2203@1|root,COG3899@1|root,COG4191@1|root,COG0515@2|Bacteria,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3899@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQX3@28211|Alphaproteobacteria,3JR5W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GAF,GAF_2,HATPase_c,HisKA,PAS_3,PAS_8,PAS_9,Pkinase
HKD1_k127_2232751_12	234267.Acid_5271	0.0002695	49.0	COG1917@1|root,COG1917@2|Bacteria,3Y4Y3@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2232751_11	713586.KB900536_gene2614	8.344e-15	86.0	COG0845@1|root,COG0845@2|Bacteria,1MVFN@1224|Proteobacteria,1RNN6@1236|Gammaproteobacteria,1WYGI@135613|Chromatiales	135613|Chromatiales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K18990	-	M00720	-	-	ko00000,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_2232751_7	1536770.R50345_17835	1.323e-41	164.0	COG0760@1|root,COG0760@2|Bacteria,1U125@1239|Firmicutes,4IAIA@91061|Bacilli,272US@186822|Paenibacillaceae	91061|Bacilli	O	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2232751_8	1487953.JMKF01000060_gene4846	1.884e-34	138.0	COG0845@1|root,COG0845@2|Bacteria,1G1YS@1117|Cyanobacteria,1H9XS@1150|Oscillatoriales	1117|Cyanobacteria	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD1_k127_2350726_29	485913.Krac_9732	5.569e-41	158.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,DLH,Peptidase_S9
HKD1_k127_2350726_17	981383.AEWH01000059_gene2206	1.284e-89	305.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,4HB6P@91061|Bacilli	91061|Bacilli	E	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD1_k127_2350726_9	436308.Nmar_0657	1.021e-137	452.0	COG1262@1|root,arCOG03517@2157|Archaea,41T1B@651137|Thaumarchaeota	651137|Thaumarchaeota	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HKD1_k127_2350726_22	1117108.PAALTS15_28746	5.331e-72	255.0	COG1595@1|root,COG1595@2|Bacteria,1V70Y@1239|Firmicutes,4HINM@91061|Bacilli,26T02@186822|Paenibacillaceae	91061|Bacilli	K	Belongs to the sigma-70 factor family. ECF subfamily	rpoD3	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	DUF1835,Sigma70_r2,Sigma70_r4_2
HKD1_k127_2350726_15	329726.AM1_0713	1.42e-93	318.0	COG1502@1|root,COG1502@2|Bacteria	2|Bacteria	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06132	ko00564,ko01100,map00564,map01100	-	R11062	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD1_k127_2350726_12	1121920.AUAU01000012_gene2645	1.834e-105	349.0	COG0320@1|root,COG0320@2|Bacteria,3Y3D4@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_2350726_18	706587.Desti_3062	4.737e-87	301.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,42NGU@68525|delta/epsilon subdivisions,2WIM5@28221|Deltaproteobacteria,2MQ6W@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_2350726_8	452637.Oter_3628	5.81e-140	455.0	COG4198@1|root,COG4198@2|Bacteria,46S83@74201|Verrucomicrobia,3K7UU@414999|Opitutae	414999|Opitutae	S	Protein of unknown function (DUF1015)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1015
HKD1_k127_2350726_33	1279009.ADICEAN_02760	1.526e-36	143.0	COG2318@1|root,COG2318@2|Bacteria,4NRAP@976|Bacteroidetes,47NZT@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_2350726_24	1278073.MYSTI_02759	3.552e-67	239.0	COG1218@1|root,COG1218@2|Bacteria,1N0GY@1224|Proteobacteria,42QY6@68525|delta/epsilon subdivisions,2WN05@28221|Deltaproteobacteria,2YV4R@29|Myxococcales	28221|Deltaproteobacteria	P	Inositol monophosphatase family	cysQ	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
HKD1_k127_2350726_2	1173028.ANKO01000147_gene1308	2.108e-182	584.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1H9S6@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86	ko:K01580,ko:K01593,ko:K13745	ko00250,ko00260,ko00350,ko00360,ko00380,ko00410,ko00430,ko00650,ko00901,ko00950,ko00965,ko01100,ko01110,ko01120,ko02024,ko04726,ko04727,ko04728,ko04940,ko05030,ko05031,ko05034,map00250,map00260,map00350,map00360,map00380,map00410,map00430,map00650,map00901,map00950,map00965,map01100,map01110,map01120,map02024,map04726,map04727,map04728,map04940,map05030,map05031,map05034	M00027,M00037,M00042	R00261,R00489,R00685,R00699,R00736,R01682,R02080,R02466,R02701,R04909,R07650	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_2350726_14	3218.PP1S46_300V6.1	2.749e-99	336.0	COG0667@1|root,2S0PI@2759|Eukaryota,37UGN@33090|Viridiplantae,3GP0T@35493|Streptophyta	35493|Streptophyta	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_2350726_3	234267.Acid_3960	2.959e-169	540.0	COG0111@1|root,COG0111@2|Bacteria,3Y7TQ@57723|Acidobacteria	57723|Acidobacteria	EH	D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_2350726_21	163908.KB235896_gene3463	5.334e-74	258.0	COG0300@1|root,COG0300@2|Bacteria,1G2JD@1117|Cyanobacteria,1HJWF@1161|Nostocales	1117|Cyanobacteria	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD1_k127_2350726_7	1120985.AUMI01000011_gene435	1.331e-140	456.0	COG1932@1|root,COG1932@2|Bacteria,1TP6Y@1239|Firmicutes,4H26T@909932|Negativicutes	909932|Negativicutes	E	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_2350726_34	287.DR97_2906	5.363e-34	135.0	2AIIQ@1|root,3190S@2|Bacteria,1RHWT@1224|Proteobacteria,1S774@1236|Gammaproteobacteria,1YG24@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	SMI1-KNR4 cell-wall	IV02_22940	-	-	-	-	-	-	-	-	-	-	-	SUKH_5
HKD1_k127_2350726_39	1121904.ARBP01000027_gene718	2.605e-17	86.0	28TN6@1|root,2ZFVP@2|Bacteria,4NMZM@976|Bacteroidetes,47WNX@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2350726_6	204669.Acid345_3484	9.921e-147	473.0	COG0823@1|root,COG0823@2|Bacteria,3Y36H@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_2350726_10	945713.IALB_1883	4.263e-135	453.0	COG0265@1|root,COG2234@1|root,COG0265@2|Bacteria,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	PA,PD40,PDZ_2,Peptidase_M28
HKD1_k127_2350726_35	335543.Sfum_0084	1.302e-33	133.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MS96@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_2350726_41	215803.DB30_8216	0.0002925	52.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW	-	-	ko:K02659,ko:K03408	ko02020,ko02025,ko02030,map02020,map02025,map02030	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	CheW
HKD1_k127_2350726_32	1121015.N789_04655	2.833e-39	150.0	COG0599@1|root,COG0599@2|Bacteria,1N38Z@1224|Proteobacteria,1S5G6@1236|Gammaproteobacteria,1X6C8@135614|Xanthomonadales	135614|Xanthomonadales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_2350726_1	247490.KSU1_C0443	1.655e-198	639.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,2IXWV@203682|Planctomycetes	203682|Planctomycetes	CO	PFAM NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Thioredoxin_8
HKD1_k127_2350726_19	977880.RALTA_A1787	8.765e-84	280.0	COG2193@1|root,COG2193@2|Bacteria,1RAQ8@1224|Proteobacteria,2VQHR@28216|Betaproteobacteria,1K074@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Ferritin, Dps family protein	bfr3	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD1_k127_2350726_36	1178540.BA70_15560	1.01e-32	139.0	COG0457@1|root,COG0705@1|root,COG0457@2|Bacteria,COG0705@2|Bacteria,1TQXT@1239|Firmicutes,4HCDF@91061|Bacilli,1ZBV7@1386|Bacillus	91061|Bacilli	O	membrane protein (homolog of Drosophila rhomboid)	gluP	-	3.4.21.105	ko:K19225	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Rhomboid,TPR_2,TPR_8
HKD1_k127_2350726_11	204669.Acid345_1212	2.659e-125	407.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria,2JI6S@204432|Acidobacteriia	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_2350726_23	1120960.ATXG01000001_gene1272	1.422e-67	238.0	COG1126@1|root,COG1126@2|Bacteria,2GIZW@201174|Actinobacteria,4FKV9@85023|Microbacteriaceae	201174|Actinobacteria	E	ATPases associated with a variety of cellular activities	atrC	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD1_k127_2350726_13	1278073.MYSTI_06072	1.637e-101	349.0	COG0765@1|root,COG0834@1|root,COG0765@2|Bacteria,COG0834@2|Bacteria,1MWF0@1224|Proteobacteria,42PF3@68525|delta/epsilon subdivisions,2X5DP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
HKD1_k127_2350726_4	1499967.BAYZ01000095_gene4135	1.936e-158	511.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	pepQ	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_2350726_5	204669.Acid345_3059	5.449e-148	485.0	COG1816@1|root,COG1816@2|Bacteria,3Y3TN@57723|Acidobacteria,2JIUT@204432|Acidobacteriia	204432|Acidobacteriia	F	PFAM Adenosine AMP deaminase	-	-	3.5.4.4	ko:K01488	ko00230,ko01100,ko05340,map00230,map01100,map05340	-	R01560,R02556	RC00477	ko00000,ko00001,ko01000	-	-	-	A_deaminase
HKD1_k127_2350726_20	309801.trd_0178	2.471e-81	278.0	COG0483@1|root,COG0483@2|Bacteria,2G6JD@200795|Chloroflexi,27Y5G@189775|Thermomicrobia	189775|Thermomicrobia	G	Inositol monophosphatase family	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_2350726_37	645127.ckrop_0219	3.628e-21	102.0	COG0204@1|root,COG0561@1|root,COG0204@2|Bacteria,COG0561@2|Bacteria,2GKM6@201174|Actinobacteria,22KYP@1653|Corynebacteriaceae	201174|Actinobacteria	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_2350726_0	316067.Geob_0005	4.47e-297	933.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,42KZ9@68525|delta/epsilon subdivisions,2WJBC@28221|Deltaproteobacteria,43T5S@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_2350726_26	292459.STH3180	1.809e-57	208.0	COG0314@1|root,COG1977@1|root,COG0314@2|Bacteria,COG1977@2|Bacteria,1V3V0@1239|Firmicutes,24QVX@186801|Clostridia	186801|Clostridia	H	Molybdopterin converting factor subunit	-	-	2.8.1.12	ko:K03635,ko:K21142	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09395	RC02507	ko00000,ko00001,ko01000	-	-	-	MoaE,ThiS
HKD1_k127_2350726_30	861299.J421_2526	1.133e-40	159.0	COG2802@1|root,COG2802@2|Bacteria,1ZUZ8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	ATP-dependent protease La (LON) substrate-binding domain	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	LON_substr_bdg
HKD1_k127_2350726_28	266117.Rxyl_2043	2.545e-48	174.0	COG2154@1|root,COG2154@2|Bacteria,2HPFQ@201174|Actinobacteria,4CQU3@84995|Rubrobacteria	84995|Rubrobacteria	H	Transcriptional coactivator pterin dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD1_k127_2350726_27	204669.Acid345_3344	4.323e-50	192.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HKD1_k127_2350726_31	1340493.JNIF01000003_gene1803	9.046e-40	162.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HKD1_k127_2350726_38	593750.Metfor_1886	7.718e-18	100.0	COG0642@1|root,COG0745@1|root,arCOG02378@2157|Archaea,arCOG02592@2157|Archaea,2Y7NY@28890|Euryarchaeota	28890|Euryarchaeota	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_2350726_16	706587.Desti_3017	1.082e-90	339.0	COG0784@1|root,COG2202@1|root,COG2204@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42MC4@68525|delta/epsilon subdivisions,2WIU5@28221|Deltaproteobacteria,2MQZQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_2350726_40	263358.VAB18032_22525	3.718e-08	59.0	2DXV2@1|root,346SA@2|Bacteria,2HWZY@201174|Actinobacteria,4DKUT@85008|Micromonosporales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2350726_25	1094715.CM001373_gene1274	1.24e-64	236.0	COG0332@1|root,COG0332@2|Bacteria	2|Bacteria	I	beta-ketoacyl-acyl-carrier-protein synthase III activity	-	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_2376104_29	1047013.AQSP01000108_gene2065	3.093e-07	52.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NQEH@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_2376104_21	861299.J421_4047	8.76e-37	154.0	COG1680@1|root,COG1680@2|Bacteria,1ZTJS@142182|Gemmatimonadetes	2|Bacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,Cu_amine_oxidN1,DUF3471
HKD1_k127_2376104_4	886377.Murru_3303	4.713e-213	676.0	COG3653@1|root,COG3653@2|Bacteria,4NHDD@976|Bacteroidetes,1HYSX@117743|Flavobacteriia	976|Bacteroidetes	Q	COG3653 N-acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD1_k127_2376104_2	861299.J421_6087	7.607e-255	801.0	COG2936@1|root,COG2936@2|Bacteria,1ZTD6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HKD1_k127_2376104_13	1120705.FG95_00881	9.324e-90	310.0	COG1680@1|root,COG1680@2|Bacteria,1MVPR@1224|Proteobacteria,2TQRF@28211|Alphaproteobacteria,2KD3V@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_2376104_12	1144275.COCOR_05979	2.065e-99	338.0	COG3391@1|root,COG3391@2|Bacteria,1MY07@1224|Proteobacteria,439IC@68525|delta/epsilon subdivisions,2X4US@28221|Deltaproteobacteria,2Z08D@29|Myxococcales	28221|Deltaproteobacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2376104_1	756272.Plabr_2480	4.161e-268	835.0	COG0008@1|root,COG0008@2|Bacteria,2IYSE@203682|Planctomycetes	203682|Planctomycetes	J	tRNA synthetases class I (E and Q), anti-codon binding domain	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD1_k127_2376104_5	1123023.JIAI01000014_gene3773	6.687e-199	633.0	COG0008@1|root,COG0008@2|Bacteria,2GJJS@201174|Actinobacteria,4E0NK@85010|Pseudonocardiales	201174|Actinobacteria	J	tRNA synthetases class I (E and Q), catalytic domain	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_2376104_19	401053.AciPR4_0727	3.674e-48	179.0	COG0252@1|root,COG0252@2|Bacteria,3Y8TG@57723|Acidobacteria	57723|Acidobacteria	EJ	Asparaginase	-	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD1_k127_2376104_10	1267535.KB906767_gene4727	1.847e-112	370.0	COG0500@1|root,COG2226@2|Bacteria,3Y4B3@57723|Acidobacteria,2JJG1@204432|Acidobacteriia	204432|Acidobacteriia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_2376104_15	485913.Krac_4939	4.271e-80	275.0	COG2120@1|root,COG2120@2|Bacteria,2G9IP@200795|Chloroflexi	200795|Chloroflexi	S	GlcNAc-PI de-N-acetylase	-	-	-	-	-	-	-	-	-	-	-	-	PIG-L
HKD1_k127_2376104_7	869210.Marky_1927	9.117e-182	582.0	COG0076@1|root,COG0076@2|Bacteria,1WKXN@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	COG0076 Glutamate decarboxylase and related PLP-dependent	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_2376104_6	234267.Acid_4393	6.44e-183	605.0	COG0515@1|root,COG0515@2|Bacteria	234267.Acid_4393|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2376104_30	204669.Acid345_2219	1.749e-05	48.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y9GC@57723|Acidobacteria,2JKTW@204432|Acidobacteriia	204432|Acidobacteriia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_2376104_9	204669.Acid345_4396	3.157e-139	473.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_2376104_24	1267533.KB906738_gene2202	1.169e-29	124.0	COG2197@1|root,COG2197@2|Bacteria,3Y8R3@57723|Acidobacteria,2JNDY@204432|Acidobacteriia	204432|Acidobacteriia	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_2376104_18	204669.Acid345_4067	5.447e-53	195.0	COG2197@1|root,COG2197@2|Bacteria,3Y7QM@57723|Acidobacteria,2JMPR@204432|Acidobacteriia	204432|Acidobacteriia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_2376104_17	443144.GM21_3722	2.463e-58	225.0	COG2202@1|root,COG4191@1|root,COG2202@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,42M1R@68525|delta/epsilon subdivisions,2WJ5T@28221|Deltaproteobacteria,43SYP@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg,dCache_1
HKD1_k127_2376104_8	991.IW20_22815	1.087e-181	596.0	COG5164@1|root,COG5164@2|Bacteria,4NFN0@976|Bacteroidetes,1IMWB@117743|Flavobacteriia,2NVM5@237|Flavobacterium	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2376104_23	639030.JHVA01000001_gene3102	1.005e-34	139.0	2C852@1|root,32YB2@2|Bacteria,3Y55S@57723|Acidobacteria,2JJNG@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD1_k127_2376104_3	1267534.KB906756_gene140	8.602e-243	782.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_17
HKD1_k127_2376104_20	1356852.N008_03090	2.63e-47	181.0	29SM0@1|root,30DSB@2|Bacteria,4NQ72@976|Bacteroidetes,47QJW@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD1_k127_2376104_25	234267.Acid_3392	6.752e-22	105.0	2E74W@1|root,331P9@2|Bacteria,3Y8XR@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HKD1_k127_2376104_27	1144312.PMI09_05370	4.708e-13	69.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD1_k127_2376104_28	1232437.KL662056_gene5445	7.541e-12	71.0	COG4313@1|root,COG4313@2|Bacteria,1R6GU@1224|Proteobacteria,43BI4@68525|delta/epsilon subdivisions,2X6WJ@28221|Deltaproteobacteria,2MKN8@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD1_k127_2376104_14	1532558.JL39_15385	2.489e-85	295.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD1_k127_2376104_26	639030.JHVA01000001_gene3181	7.582e-16	86.0	2C6A3@1|root,34625@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2376104_11	1217718.ALOU01000007_gene1259	1.315e-100	338.0	COG2370@1|root,COG2370@2|Bacteria,1MV6Z@1224|Proteobacteria,2VM5U@28216|Betaproteobacteria,1KF02@119060|Burkholderiaceae	28216|Betaproteobacteria	O	HupE / UreJ protein	-	-	-	-	-	-	-	-	-	-	-	-	HupE_UreJ_2
HKD1_k127_2376104_16	1500301.JQMF01000022_gene5641	1.255e-70	250.0	COG0760@1|root,COG0760@2|Bacteria,1R4ZR@1224|Proteobacteria,2U874@28211|Alphaproteobacteria,4B9DE@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2
HKD1_k127_2376104_0	1132836.RCCGE510_20779	0.0	1056.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD1_k127_2380324_4	861299.J421_5995	6.097e-86	310.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	AAA_16,Abhydrolase_1,PD40,Trans_reg_C
HKD1_k127_2380324_1	925409.KI911562_gene932	5.171e-155	500.0	COG4932@1|root,COG4932@2|Bacteria,4NGQK@976|Bacteroidetes,1IPJG@117747|Sphingobacteriia	976|Bacteroidetes	M	Domain of unknown function (DUF3472)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3472,DUF5077,F5_F8_type_C
HKD1_k127_2380324_14	639283.Snov_1317	8.23e-12	67.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2TU6F@28211|Alphaproteobacteria,3F18H@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_2380324_18	56780.SYN_02530	6.021e-05	50.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2MRFD@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Bacterial regulatory protein, Fis family	pilR	-	-	ko:K02667	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_2380324_12	1278073.MYSTI_07740	2.11e-14	77.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria	1224|Proteobacteria	V	COG0577 ABC-type antimicrobial peptide transport system permease component	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_2380324_10	1040987.AZUY01000002_gene3689	1.092e-47	183.0	COG0583@1|root,COG0583@2|Bacteria,1R55T@1224|Proteobacteria,2U445@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_2380324_9	748280.NH8B_2523	2.336e-51	185.0	COG2050@1|root,COG2050@2|Bacteria,1MZRJ@1224|Proteobacteria,2VSE3@28216|Betaproteobacteria,2KS8D@206351|Neisseriales	206351|Neisseriales	Q	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_2380324_20	196367.JNFG01000007_gene6784	8.775e-05	46.0	COG0679@1|root,COG0679@2|Bacteria,1PINE@1224|Proteobacteria,2VNZA@28216|Betaproteobacteria,1K3RC@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Membrane transport protein	-	-	-	-	-	-	-	-	-	-	-	-	Mem_trans
HKD1_k127_2380324_7	86416.Clopa_2530	5.911e-60	216.0	COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,24ADY@186801|Clostridia,36G2E@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
HKD1_k127_2380324_19	1121127.JAFA01000016_gene3195	7.549e-05	48.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2VQ5D@28216|Betaproteobacteria,1JZNC@119060|Burkholderiaceae	28216|Betaproteobacteria	J	endoribonuclease L-PSP	tdcF2	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD1_k127_2380324_5	479434.Sthe_3051	5.107e-67	240.0	COG0384@1|root,COG0384@2|Bacteria,2G7U6@200795|Chloroflexi,27ZAQ@189775|Thermomicrobia	189775|Thermomicrobia	S	Phenazine biosynthesis-like protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_2380324_13	768706.Desor_1854	4.952e-14	75.0	COG0251@1|root,COG0251@2|Bacteria,1VD2R@1239|Firmicutes,24IJD@186801|Clostridia,2655D@186807|Peptococcaceae	186801|Clostridia	J	Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_2380324_17	323259.Mhun_2495	2.493e-05	53.0	arCOG03264@1|root,arCOG03264@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PEGA
HKD1_k127_2380324_11	446466.Cfla_0266	4.971e-33	133.0	COG0662@1|root,COG0662@2|Bacteria,2II1B@201174|Actinobacteria	201174|Actinobacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_2380324_0	1340493.JNIF01000003_gene2089	1.591e-252	815.0	COG1629@1|root,COG1629@2|Bacteria,3Y67H@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_2380324_2	204669.Acid345_2716	3.459e-144	494.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_2380324_8	234267.Acid_1209	7.547e-58	206.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_2473648_20	1183438.GKIL_3942	3.834e-57	206.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_2473648_5	1379698.RBG1_1C00001G0607	5.862e-174	577.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_2473648_2	234267.Acid_5921	4.429e-220	719.0	COG1629@1|root,COG4771@2|Bacteria	2|Bacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HKD1_k127_2473648_17	1122604.JONR01000025_gene4602	1.452e-86	310.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_2473648_19	56107.Cylst_0299	1.238e-57	214.0	COG0457@1|root,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1HJ4A@1161|Nostocales	1117|Cyanobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
HKD1_k127_2473648_27	1336237.JAEE01000001_gene1619	0.0008996	43.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2473648_8	234267.Acid_2022	3.729e-146	475.0	COG0104@1|root,COG0104@2|Bacteria,3Y2Z9@57723|Acidobacteria	57723|Acidobacteria	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_2473648_23	396595.TK90_2468	2.256e-36	140.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,1S5WR@1236|Gammaproteobacteria,1WYTD@135613|Chromatiales	135613|Chromatiales	O	Belongs to the thioredoxin family	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_2473648_11	234267.Acid_0307	8.85e-118	395.0	COG0297@1|root,COG0297@2|Bacteria,3Y3IH@57723|Acidobacteria	57723|Acidobacteria	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	-	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_2473648_1	234267.Acid_2029	2.516e-222	697.0	COG1158@1|root,COG1158@2|Bacteria,3Y2V3@57723|Acidobacteria	57723|Acidobacteria	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD1_k127_2473648_21	868595.Desca_0689	2.464e-53	193.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,261YZ@186807|Peptococcaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD1_k127_2473648_22	1267535.KB906767_gene2786	1.564e-39	151.0	2DB97@1|root,32TX2@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2473648_0	56780.SYN_02787	1.576e-252	803.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,42M9W@68525|delta/epsilon subdivisions,2WJ29@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon-2	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_2473648_10	1267535.KB906767_gene1738	6.488e-123	417.0	COG3829@1|root,COG3829@2|Bacteria,3Y6K2@57723|Acidobacteria	57723|Acidobacteria	KT	Inner membrane component of T3SS, cytoplasmic domain	-	-	-	-	-	-	-	-	-	-	-	-	Sigma54_activat,Yop-YscD_cpl
HKD1_k127_2473648_6	671143.DAMO_2181	4.121e-172	550.0	COG1219@1|root,COG1219@2|Bacteria,2NNN2@2323|unclassified Bacteria	2|Bacteria	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	GO:0000166,GO:0000502,GO:0002020,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009376,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019538,GO:0019899,GO:0019904,GO:0030163,GO:0030164,GO:0030312,GO:0030554,GO:0031333,GO:0031597,GO:0032271,GO:0032272,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0035639,GO:0036094,GO:0040007,GO:0042623,GO:0042802,GO:0043167,GO:0043168,GO:0043170,GO:0043254,GO:0043335,GO:0044087,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051128,GO:0051129,GO:0051301,GO:0051704,GO:0065007,GO:0070011,GO:0071704,GO:0071944,GO:0097159,GO:0097367,GO:0097718,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD1_k127_2473648_16	590409.Dd586_1032	2.359e-89	297.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,1RNR6@1236|Gammaproteobacteria,2JBXK@204037|Dickeya	1236|Gammaproteobacteria	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	GO:0000502,GO:0003674,GO:0003824,GO:0004176,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009314,GO:0009376,GO:0009408,GO:0009628,GO:0009987,GO:0010498,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017171,GO:0019538,GO:0019899,GO:0030163,GO:0031597,GO:0032991,GO:0042623,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0050896,GO:0051117,GO:0051603,GO:0070011,GO:0071704,GO:0140096,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1904949,GO:1905368,GO:1905369	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_2473648_18	204669.Acid345_1561	4.514e-79	280.0	COG0544@1|root,COG0544@2|Bacteria,3Y45D@57723|Acidobacteria,2JIVB@204432|Acidobacteriia	204432|Acidobacteriia	O	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_2473648_14	292564.Cyagr_2454	4.054e-114	383.0	COG0531@1|root,COG0531@2|Bacteria,1G2GM@1117|Cyanobacteria,22S6X@167375|Cyanobium	1117|Cyanobacteria	E	amino acid	-	-	-	ko:K03294,ko:K13868	ko04974,map04974	-	-	-	ko00000,ko00001,ko02000	2.A.3.2,2.A.3.8.15	-	-	AA_permease_2
HKD1_k127_2473648_12	234267.Acid_1598	6.871e-115	379.0	COG0449@1|root,COG0449@2|Bacteria	2|Bacteria	M	glutamine-fructose-6-phosphate transaminase (isomerizing) activity	glmD	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	SIS
HKD1_k127_2473648_7	861299.J421_3029	3.262e-153	508.0	COG3525@1|root,COG3525@2|Bacteria	2|Bacteria	G	beta-N-acetylhexosaminidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_20,Glyco_hydro_20b
HKD1_k127_2473648_13	452471.Aasi_1258	2.016e-114	380.0	COG4299@1|root,COG4299@2|Bacteria,4NDZF@976|Bacteroidetes,47JVV@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1624)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF5009
HKD1_k127_2473648_24	1267533.KB906743_gene818	5.088e-27	112.0	COG4274@1|root,COG4274@2|Bacteria	2|Bacteria	S	GYD domain	-	-	-	-	-	-	-	-	-	-	-	-	GYD
HKD1_k127_2473648_4	204669.Acid345_3836	1.062e-175	567.0	COG2027@1|root,COG3653@1|root,COG2027@2|Bacteria,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD1_k127_2473648_9	292459.STH1206	5.786e-125	416.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_2473648_15	504472.Slin_4173	4.337e-113	381.0	COG0531@1|root,COG0531@2|Bacteria,4NDU2@976|Bacteroidetes,47M3Z@768503|Cytophagia	976|Bacteroidetes	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_2473648_3	1382359.JIAL01000001_gene1021	2.857e-188	603.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria,2JIRH@204432|Acidobacteriia	204432|Acidobacteriia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_2511082_5	1192034.CAP_8937	1.218e-24	108.0	COG0539@1|root,COG0539@2|Bacteria	2|Bacteria	J	ribosomal small subunit biogenesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
HKD1_k127_2511082_7	189753.AXAS01000013_gene5750	1.056e-15	89.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_2511082_6	886293.Sinac_2696	9.796e-17	97.0	COG3420@1|root,COG3420@2|Bacteria,2J2MQ@203682|Planctomycetes	203682|Planctomycetes	P	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
HKD1_k127_2511082_0	589865.DaAHT2_0329	0.0	1540.0	COG3209@1|root,COG3386@1|root,COG3391@1|root,COG5492@1|root,COG3209@2|Bacteria,COG3386@2|Bacteria,COG3391@2|Bacteria,COG5492@2|Bacteria,1MVV1@1224|Proteobacteria,43AER@68525|delta/epsilon subdivisions,2X5UG@28221|Deltaproteobacteria,2MN6Q@213118|Desulfobacterales	28221|Deltaproteobacteria	GM	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,NHL,RHS_repeat
HKD1_k127_2511082_8	1415779.JOMH01000001_gene124	2.968e-12	79.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT,PMT_2
HKD1_k127_2511082_2	661478.OP10G_2830	3.309e-108	362.0	COG0489@1|root,COG0489@2|Bacteria	2|Bacteria	D	protein tyrosine kinase activity	mrp	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	FeS_assembly_P,ParA
HKD1_k127_2511082_4	861299.J421_3606	1.716e-34	136.0	COG0316@1|root,COG0316@2|Bacteria,1ZTT0@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Iron-sulphur cluster biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
HKD1_k127_2511082_3	562970.Btus_2079	7.743e-46	173.0	COG0454@1|root,COG0456@2|Bacteria,1V562@1239|Firmicutes,4HMAE@91061|Bacilli	91061|Bacilli	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_2511082_1	1411123.JQNH01000001_gene261	3.139e-250	784.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TT2P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	elongator protein 3 miab nifb	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_2549884_6	755731.Clo1100_0574	3.449e-97	358.0	COG1864@1|root,COG2374@1|root,COG1864@2|Bacteria,COG2374@2|Bacteria	2|Bacteria	F	neuron death in response to oxidative stress	nucA	-	-	ko:K01173,ko:K07004	ko04210,map04210	-	-	-	ko00000,ko00001,ko03029	-	-	-	Endonuclease_NS,Exo_endo_phos,LTD
HKD1_k127_2549884_7	1122201.AUAZ01000001_gene2338	6.103e-92	342.0	COG2304@1|root,COG2304@2|Bacteria,1QU09@1224|Proteobacteria,1T39R@1236|Gammaproteobacteria,46DBS@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,RHS_repeat
HKD1_k127_2549884_11	671143.DAMO_2379	9.201e-57	201.0	COG0822@1|root,COG0822@2|Bacteria,2NPXN@2323|unclassified Bacteria	2|Bacteria	C	NifU-like N terminal domain	nifU	GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006807,GO:0006873,GO:0006875,GO:0006879,GO:0008150,GO:0008152,GO:0008198,GO:0009987,GO:0010467,GO:0016740,GO:0016782,GO:0019538,GO:0019725,GO:0030003,GO:0036455,GO:0042592,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044464,GO:0046872,GO:0046914,GO:0046916,GO:0048037,GO:0048878,GO:0050801,GO:0051536,GO:0051537,GO:0051539,GO:0051540,GO:0051604,GO:0055065,GO:0055072,GO:0055076,GO:0055080,GO:0055082,GO:0065007,GO:0065008,GO:0071704,GO:0097428,GO:0098771,GO:1901564	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_2549884_2	1266925.JHVX01000003_gene433	3.88e-182	578.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2VIQW@28216|Betaproteobacteria,371MB@32003|Nitrosomonadales	28216|Betaproteobacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_2549884_5	671143.DAMO_2381	1.035e-97	336.0	COG0719@1|root,COG0719@2|Bacteria,2NPGC@2323|unclassified Bacteria	2|Bacteria	O	FeS assembly protein SufD	sufD	GO:0006790,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0050896,GO:0051186,GO:0071840	-	ko:K07033,ko:K09015	-	-	-	-	ko00000	-	-	iB21_1397.B21_01640,iECBD_1354.ECBD_1964,iECB_1328.ECB_01650,iECD_1391.ECD_01650,iUMNK88_1353.UMNK88_2144	UPF0051
HKD1_k127_2549884_4	945713.IALB_2894	1.009e-116	381.0	COG0396@1|root,COG0396@2|Bacteria	2|Bacteria	O	ATPase activity	sufC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006790,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0016043,GO:0016226,GO:0022607,GO:0031163,GO:0044085,GO:0044237,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051186,GO:0071840	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	iECH74115_1262.ECH74115_2396,iECIAI1_1343.ECIAI1_1734,iECIAI39_1322.ECIAI39_1376,iECSP_1301.ECSP_2249,iECs_1301.ECs2389,iEcSMS35_1347.EcSMS35_1514,iG2583_1286.G2583_2077,iSFV_1184.SFV_1705,iSFxv_1172.SFxv_1919,iSSON_1240.SSON_1474,iS_1188.S1844,iZ_1308.Z2710	ABC_tran
HKD1_k127_2549884_0	395961.Cyan7425_3450	6.095e-253	786.0	COG0719@1|root,COG0719@2|Bacteria,1G0TH@1117|Cyanobacteria,3KFRF@43988|Cyanothece	1117|Cyanobacteria	O	TIGRFAM FeS assembly protein SufB	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_2549884_12	234267.Acid_7705	1.089e-26	115.0	COG1959@1|root,COG1959@2|Bacteria,3Y7VG@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_2549884_8	682795.AciX8_3966	8.251e-89	306.0	COG0642@1|root,COG2205@2|Bacteria,3Y2W3@57723|Acidobacteria,2JIDP@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA
HKD1_k127_2549884_9	204669.Acid345_0509	2.262e-84	285.0	COG0745@1|root,COG0745@2|Bacteria,3Y4R4@57723|Acidobacteria,2JJBD@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_2549884_1	1128421.JAGA01000002_gene269	4.921e-199	640.0	COG0531@1|root,COG0531@2|Bacteria,2NNZQ@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_2549884_3	1205681.CALW02000005_gene395	5.799e-131	432.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,48TNC@772|Bartonellaceae	28211|Alphaproteobacteria	P	Acts as a magnesium transporter	mgtE	GO:0000287,GO:0003674,GO:0005488,GO:0005515,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0015693,GO:0030001,GO:0042802,GO:0042803,GO:0043167,GO:0043169,GO:0046872,GO:0046983,GO:0051179,GO:0051234,GO:0070838,GO:0072511	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD1_k127_2549884_10	317936.Nos7107_2202	3.051e-62	221.0	COG0402@1|root,COG0402@2|Bacteria,1GCK3@1117|Cyanobacteria,1HS6K@1161|Nostocales	1117|Cyanobacteria	F	Amidohydrolase family	-	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_2601911_1	204669.Acid345_4221	1.389e-98	336.0	COG0787@1|root,COG0787@2|Bacteria,3Y2U3@57723|Acidobacteria,2JI6I@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	-	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD1_k127_2601911_0	926692.AZYG01000047_gene2664	5.566e-132	436.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,3WANE@53433|Halanaerobiales	186801|Clostridia	L	Replicative DNA helicase	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD1_k127_2883_1	234267.Acid_5940	3.088e-187	616.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_2883_3	269799.Gmet_3036	8.463e-121	401.0	COG0577@1|root,COG0577@2|Bacteria,1PBKH@1224|Proteobacteria,42MAR@68525|delta/epsilon subdivisions,2WJEU@28221|Deltaproteobacteria,43THP@69541|Desulfuromonadales	28221|Deltaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2883_5	1118054.CAGW01000060_gene2571	3.569e-94	317.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,4HBMF@91061|Bacilli,26R6I@186822|Paenibacillaceae	91061|Bacilli	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_2883_6	215803.DB30_2998	3.638e-81	287.0	COG0845@1|root,COG0845@2|Bacteria,1MU8D@1224|Proteobacteria,42NVA@68525|delta/epsilon subdivisions,2WMQK@28221|Deltaproteobacteria,2YWS4@29|Myxococcales	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	HlyD_D23
HKD1_k127_2883_11	1173263.Syn7502_00786	2.995e-05	55.0	COG4252@1|root,COG4252@2|Bacteria	2|Bacteria	T	Chase2 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,DUF928
HKD1_k127_2883_2	335543.Sfum_3983	1.806e-153	524.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,42T1Q@68525|delta/epsilon subdivisions,2X5JE@28221|Deltaproteobacteria	28221|Deltaproteobacteria	KLT	Tetratricopeptide repeat	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	CHAT,NB-ARC,Pkinase,TIR_2,TPR_12,TPR_16,TPR_2,TPR_4,TPR_7,TPR_8
HKD1_k127_2883_7	711393.AYRX01000083_gene4764	2.545e-65	229.0	2B37N@1|root,31VVP@2|Bacteria,2GWAN@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_2883_8	472759.Nhal_1647	9.047e-58	207.0	COG1278@1|root,COG1278@2|Bacteria,1QW5N@1224|Proteobacteria,1T3Z1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	Sigma 54 modulation protein / S30EA ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	CSD,Ribosomal_S30AE
HKD1_k127_2883_10	1095769.CAHF01000010_gene1115	1.771e-43	168.0	COG5637@1|root,COG5637@2|Bacteria,1RI3F@1224|Proteobacteria,2WGS9@28216|Betaproteobacteria	28216|Betaproteobacteria	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON,Polyketide_cyc
HKD1_k127_2883_4	251221.35214923	3.467e-115	382.0	COG1723@1|root,COG1723@2|Bacteria,1GFA7@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2883_0	1123393.KB891316_gene1685	1.213e-221	695.0	COG1690@1|root,COG1690@2|Bacteria,1MUHA@1224|Proteobacteria,2VJ89@28216|Betaproteobacteria,1KRE8@119069|Hydrogenophilales	119069|Hydrogenophilales	S	tRNA-splicing ligase RtcB	-	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RtcB
HKD1_k127_2883_9	292415.Tbd_2360	1.142e-54	194.0	COG0617@1|root,COG1371@1|root,COG0617@2|Bacteria,COG1371@2|Bacteria,1MU2X@1224|Proteobacteria,2VIN5@28216|Betaproteobacteria,1KRHG@119069|Hydrogenophilales	119069|Hydrogenophilales	J	Probable RNA and SrmB- binding site of polymerase A	-	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Archease,HD,PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_3032381_5	525909.Afer_1020	1.231e-157	501.0	COG0243@1|root,COG0243@2|Bacteria,2GNYQ@201174|Actinobacteria,4CNGZ@84992|Acidimicrobiia	84992|Acidimicrobiia	C	Molybdopterin oxidoreductase Fe4S4 domain	-	-	-	-	-	-	-	-	-	-	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_3032381_52	1128427.KB904821_gene162	3.615e-12	70.0	COG3668@1|root,COG3668@2|Bacteria,1G8WD@1117|Cyanobacteria,1HDM2@1150|Oscillatoriales	1117|Cyanobacteria	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	-	-	-	-	-	-	-	-	-	ParE_toxin
HKD1_k127_3032381_51	99598.Cal7507_0066	8.059e-13	70.0	2A06T@1|root,30N9Y@2|Bacteria,1GJZ0@1117|Cyanobacteria,1HSX5@1161|Nostocales	1117|Cyanobacteria	S	Putative addiction module component	-	-	-	-	-	-	-	-	-	-	-	-	Unstab_antitox
HKD1_k127_3032381_39	945713.IALB_2163	3.292e-35	152.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD1_k127_3032381_30	682795.AciX8_0041	1.783e-44	167.0	COG2318@1|root,COG2318@2|Bacteria,3Y81K@57723|Acidobacteria,2JN5E@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_3032381_1	522306.CAP2UW1_2246	2.033e-216	691.0	COG1948@1|root,COG4880@2|Bacteria,1R9N2@1224|Proteobacteria,2W1I5@28216|Betaproteobacteria	28216|Betaproteobacteria	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
HKD1_k127_3032381_45	446462.Amir_5891	2.184e-23	102.0	COG2261@1|root,COG2261@2|Bacteria,2GQR5@201174|Actinobacteria,4E75F@85010|Pseudonocardiales	201174|Actinobacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_3032381_49	219305.MCAG_02052	3.411e-13	83.0	COG2133@1|root,COG3291@1|root,COG3507@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3507@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria,4D8ZK@85008|Micromonosporales	201174|Actinobacteria	G	Protein of unknown function (DUF1349)	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1349,GSDH,PKD,ThuA
HKD1_k127_3032381_53	1408433.JHXV01000001_gene841	8.614e-09	68.0	COG1874@1|root,COG1874@2|Bacteria,4NKTY@976|Bacteroidetes,1IBEY@117743|Flavobacteriia	976|Bacteroidetes	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42
HKD1_k127_3032381_50	1163617.SCD_n00775	6.272e-13	81.0	2EBX9@1|root,335WM@2|Bacteria,1NCDM@1224|Proteobacteria,2VYXB@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3032381_54	1123248.KB893337_gene2531	5.002e-07	62.0	28KCX@1|root,2Z9ZQ@2|Bacteria,4NJ7S@976|Bacteroidetes,1IX7E@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3032381_26	945713.IALB_2758	9.008e-59	210.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_3032381_6	1121957.ATVL01000008_gene4646	1.383e-139	481.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NK8Q@976|Bacteroidetes,47KVN@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HKD1_k127_3032381_46	755732.Fluta_3065	5.58e-21	103.0	COG1277@1|root,COG1277@2|Bacteria,4NICG@976|Bacteroidetes,1HZNH@117743|Flavobacteriia	976|Bacteroidetes	S	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_2,ABC2_membrane_4
HKD1_k127_3032381_56	1280941.HY2_06890	1.48e-05	57.0	COG3568@1|root,COG3568@2|Bacteria,1RJX3@1224|Proteobacteria	1224|Proteobacteria	S	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_3032381_22	1120973.AQXL01000111_gene934	9.134e-75	263.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HBGH@91061|Bacilli,279I3@186823|Alicyclobacillaceae	91061|Bacilli	V	AAA domain, putative AbiEii toxin, Type IV TA system	bcrA	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3032381_10	1379270.AUXF01000001_gene2303	2.083e-126	432.0	COG2304@1|root,COG5426@1|root,COG2304@2|Bacteria,COG5426@2|Bacteria,1ZUB1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Putative glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase1_like
HKD1_k127_3032381_31	1267535.KB906767_gene906	1.846e-44	177.0	COG4249@1|root,COG4249@2|Bacteria,3Y6DQ@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HKD1_k127_3032381_13	1267535.KB906767_gene907	1.629e-118	414.0	COG0308@1|root,COG0457@1|root,COG0308@2|Bacteria,COG0457@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1,TPR_16,TPR_19,TPR_8
HKD1_k127_3032381_9	926566.Terro_0572	3.388e-127	415.0	COG0714@1|root,COG0714@2|Bacteria,3Y3BH@57723|Acidobacteria,2JP47@204432|Acidobacteriia	204432|Acidobacteriia	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_3032381_21	880073.Calab_3696	4.286e-78	272.0	COG1721@1|root,COG1721@2|Bacteria,2NP6B@2323|unclassified Bacteria	2|Bacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_3032381_24	379066.GAU_3103	8.28e-65	246.0	COG1572@1|root,COG2304@1|root,COG1572@2|Bacteria,COG2304@2|Bacteria,1ZUB7@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Aerotolerance regulator N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	BatA,VWA_2
HKD1_k127_3032381_8	379066.GAU_3104	4.311e-136	475.0	COG1196@1|root,COG1196@2|Bacteria,1ZU8V@142182|Gemmatimonadetes	142182|Gemmatimonadetes	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3032381_58	1210884.HG799463_gene9704	4.129e-05	50.0	COG1657@1|root,COG1657@2|Bacteria,2J52T@203682|Planctomycetes	203682|Planctomycetes	I	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HKD1_k127_3032381_36	1267535.KB906767_gene904	4.098e-36	141.0	2DBN7@1|root,2ZA2Y@2|Bacteria,3Y6N3@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4159)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4159
HKD1_k127_3032381_23	767817.Desgi_0896	6.931e-69	246.0	COG3264@1|root,COG3264@2|Bacteria,1UIZT@1239|Firmicutes,25FGD@186801|Clostridia	186801|Clostridia	M	Transporter, small conductance mechanosensitive ion channel MscS family protein	-	-	-	ko:K03442	-	-	-	-	ko00000,ko02000	1.A.23.2	-	-	MS_channel,TM_helix
HKD1_k127_3032381_55	66874.JOFS01000040_gene6787	2.568e-06	59.0	COG3568@1|root,COG3568@2|Bacteria,2GNF9@201174|Actinobacteria	201174|Actinobacteria	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_3032381_41	1265505.ATUG01000002_gene2272	1.794e-32	136.0	COG1234@1|root,COG1234@2|Bacteria,1PE64@1224|Proteobacteria,42RZR@68525|delta/epsilon subdivisions,2WMCC@28221|Deltaproteobacteria,2MIZZ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_2
HKD1_k127_3032381_15	1266925.JHVX01000009_gene149	1.287e-105	344.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2VIJ0@28216|Betaproteobacteria,371Z0@32003|Nitrosomonadales	28216|Betaproteobacteria	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HKD1_k127_3032381_29	204669.Acid345_1452	8.138e-46	171.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3032381_33	1150626.PHAMO_80150	1.718e-40	154.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2JS8T@204441|Rhodospirillales	204441|Rhodospirillales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD1_k127_3032381_20	1499967.BAYZ01000009_gene5270	1.318e-78	290.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HKD1_k127_3032381_28	317936.Nos7107_1719	8.545e-51	190.0	2ERTE@1|root,33JCN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3032381_48	1198114.AciX9_2169	5.115e-14	79.0	28UBM@1|root,2ZGH0@2|Bacteria	2|Bacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HKD1_k127_3032381_57	671143.DAMO_2984	1.953e-05	56.0	2BHGH@1|root,32BIN@2|Bacteria,2NRSQ@2323|unclassified Bacteria	2|Bacteria	S	Uncharacterised nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_5
HKD1_k127_3032381_12	63737.Npun_R0239	1.153e-121	400.0	COG2520@1|root,COG2520@2|Bacteria	2|Bacteria	J	tRNA (guanine(37)-N(1))-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_3032381_16	234267.Acid_5783	1.062e-97	341.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_3032381_0	234267.Acid_5526	1.177e-223	704.0	COG1032@1|root,COG1032@2|Bacteria,3Y2NI@57723|Acidobacteria	57723|Acidobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_3032381_25	1262915.BN574_00807	1.356e-60	220.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,4H2VA@909932|Negativicutes	909932|Negativicutes	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD1_k127_3032381_18	502025.Hoch_6645	1.035e-89	309.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,42NB6@68525|delta/epsilon subdivisions,2WIWE@28221|Deltaproteobacteria,2YZKE@29|Myxococcales	28221|Deltaproteobacteria	O	Domain present in PSD-95, Dlg, and ZO-1/2.	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3032381_35	316279.Syncc9902_0413	1.392e-36	145.0	COG0537@1|root,COG0537@2|Bacteria,1G6R2@1117|Cyanobacteria,1H0FV@1129|Synechococcus	1117|Cyanobacteria	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	hit	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_3032381_7	926566.Terro_1392	1.224e-138	453.0	COG0766@1|root,COG0766@2|Bacteria,3Y2IC@57723|Acidobacteria,2JI7D@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_3032381_44	1507.HMPREF0262_02874	2.437e-24	108.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,36JKN@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CM_2,SKI
HKD1_k127_3032381_11	240015.ACP_0159	7.534e-122	405.0	COG0128@1|root,COG0128@2|Bacteria,3Y3RH@57723|Acidobacteria,2JI7W@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_3032381_43	1340493.JNIF01000003_gene4349	1.119e-24	109.0	COG2172@1|root,COG2172@2|Bacteria,3Y4TY@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HKD1_k127_3032381_37	1297742.A176_00518	6.651e-36	139.0	COG1366@1|root,COG1366@2|Bacteria,1N7D9@1224|Proteobacteria,42WXG@68525|delta/epsilon subdivisions,2WT19@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	STAS domain	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD1_k127_3032381_40	1340493.JNIF01000003_gene4350	5.31e-34	133.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria	57723|Acidobacteria	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD1_k127_3032381_47	1335760.ASTG01000002_gene2193	2.687e-18	93.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,2K470@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_3032381_17	1144275.COCOR_00645	7.833e-94	327.0	COG4395@1|root,COG4395@2|Bacteria	2|Bacteria	S	Tim44	MA20_24770	-	-	ko:K15539	-	-	-	-	ko00000	-	-	-	Tim44
HKD1_k127_3032381_34	204669.Acid345_0553	3.757e-38	149.0	COG1329@1|root,COG1329@2|Bacteria,3Y4ZG@57723|Acidobacteria,2JMXA@204432|Acidobacteriia	204432|Acidobacteriia	K	CarD-like/TRCF domain	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD1_k127_3032381_14	525897.Dbac_2296	1.732e-118	396.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,2M7ZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Transporter-associated region	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_3032381_19	237368.SCABRO_03208	1.611e-80	282.0	COG4301@1|root,COG4301@2|Bacteria,2IXEH@203682|Planctomycetes	203682|Planctomycetes	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD1_k127_3032381_42	234267.Acid_5723	1.557e-30	134.0	COG0265@1|root,COG0265@2|Bacteria,3Y4AJ@57723|Acidobacteria	57723|Acidobacteria	O	PDZ DHR GLGF domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2
HKD1_k127_3032381_27	1121430.JMLG01000017_gene309	1.807e-53	200.0	COG0491@1|root,COG0491@2|Bacteria,1TQPX@1239|Firmicutes,24BDQ@186801|Clostridia,261Z4@186807|Peptococcaceae	186801|Clostridia	S	Zn-dependent hydrolase, glyoxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_3032381_38	1121413.JMKT01000001_gene1686	1.327e-35	141.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2X245@28221|Deltaproteobacteria,2MFSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_3032381_2	204669.Acid345_2471	1.479e-198	635.0	COG1960@1|root,COG1960@2|Bacteria,3Y2NA@57723|Acidobacteria,2JII2@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_3032381_3	234267.Acid_5695	2.226e-170	542.0	COG0183@1|root,COG0183@2|Bacteria,3Y2U4@57723|Acidobacteria	57723|Acidobacteria	I	Thiolase, C-terminal domain	-	-	2.3.1.16	ko:K00632	ko00071,ko00280,ko00281,ko00362,ko00592,ko00642,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00362,map00592,map00642,map01100,map01110,map01120,map01130,map01212	M00087,M00113	R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_3032381_32	1170562.Cal6303_2768	3.418e-43	160.0	COG0399@1|root,COG0399@2|Bacteria,1GDTU@1117|Cyanobacteria,1HSKF@1161|Nostocales	1117|Cyanobacteria	J	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_3032381_4	986075.CathTA2_3095	6.929e-167	538.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1TR8J@1239|Firmicutes,4H9XN@91061|Bacilli	91061|Bacilli	I	3-hydroxyacyl-CoA dehydrogenase	fadN	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU32840	3HCDH,3HCDH_N,ECH_1
HKD1_k127_3035579_2	929713.NIASO_18960	1.186e-76	271.0	COG0671@1|root,COG0671@2|Bacteria,4NF9W@976|Bacteroidetes,1IRBB@117747|Sphingobacteriia	976|Bacteroidetes	I	SPTR Phosphoesterase, PA-phosphatase related	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD1_k127_3035579_7	404589.Anae109_3035	3.438e-35	155.0	COG2373@1|root,COG3227@1|root,COG4412@1|root,COG2373@2|Bacteria,COG3227@2|Bacteria,COG4412@2|Bacteria,1MWWV@1224|Proteobacteria,42S3D@68525|delta/epsilon subdivisions,2WNYK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Large extracellular alpha-helical protein	-	-	-	ko:K09607	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_C13
HKD1_k127_3035579_10	1168065.DOK_13849	9.542e-06	59.0	COG2936@1|root,COG3391@1|root,COG2936@2|Bacteria,COG3391@2|Bacteria,1R4GM@1224|Proteobacteria,1RRE7@1236|Gammaproteobacteria,1J8R8@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S15,TSP_3
HKD1_k127_3035579_5	13035.Dacsa_2593	8.914e-55	218.0	COG3210@1|root,COG3210@2|Bacteria,1GPZ7@1117|Cyanobacteria	2|Bacteria	U	Parallel beta-helix repeats	mshQ	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Laminin_G_3
HKD1_k127_3035579_0	1267535.KB906767_gene4240	1.742e-100	351.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HKD1_k127_3035579_8	247633.GP2143_11489	1.291e-33	144.0	COG2010@1|root,COG3420@1|root,COG2010@2|Bacteria,COG3420@2|Bacteria,1QUPB@1224|Proteobacteria,1T2I7@1236|Gammaproteobacteria,1J4SI@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	C	COG3420 Nitrous oxidase accessory protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,NosD
HKD1_k127_3035579_4	234267.Acid_2174	7.336e-65	239.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	CHRD,Calx-beta,F5_F8_type_C,PA14,RicinB_lectin_2,Ricin_B_lectin,SdrD_B
HKD1_k127_3035579_3	459495.SPLC1_S540020	1.049e-69	271.0	COG2931@1|root,COG2931@2|Bacteria,1G0ZC@1117|Cyanobacteria,1H8KD@1150|Oscillatoriales	1117|Cyanobacteria	Q	PFAM Hemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Calx-beta,Chlam_PMP,DUF1573,DUF4347,HemolysinCabind
HKD1_k127_3035579_9	867845.KI911784_gene1323	8.329e-08	67.0	COG1361@1|root,COG1404@1|root,COG2374@1|root,COG2931@1|root,COG3266@1|root,COG3291@1|root,COG3391@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG3266@2|Bacteria,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	bhp	-	3.5.1.28	ko:K01448,ko:K07004,ko:K13735,ko:K20276,ko:K21449	ko01503,ko02024,ko05100,map01503,map02024,map05100	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko02000,ko03036	1.B.40.2	-	-	Big_5,Calx-beta,DUF4347,Exo_endo_phos,LTD
HKD1_k127_3035579_1	234267.Acid_3225	8.95e-100	348.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C
HKD1_k127_3035579_6	903818.KI912268_gene1803	1.014e-50	186.0	COG0694@1|root,COG0694@2|Bacteria	2|Bacteria	O	iron-sulfur cluster assembly	nifU	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
HKD1_k127_3105809_1	880073.Calab_0325	8.372e-169	539.0	COG1013@1|root,COG1014@1|root,COG1013@2|Bacteria,COG1014@2|Bacteria,2NNMC@2323|unclassified Bacteria	2|Bacteria	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	porG	-	1.2.7.11,1.2.7.3,1.2.7.7	ko:K00175,ko:K00177,ko:K00187	ko00010,ko00020,ko00280,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00280,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197,R07160,R08566,R08567	RC00004,RC02742,RC02833,RC02856	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,TPP_enzyme_C
HKD1_k127_3105809_2	234267.Acid_1871	2.033e-144	469.0	COG0674@1|root,COG0674@2|Bacteria,3Y3NB@57723|Acidobacteria	57723|Acidobacteria	C	Pyruvate:ferredoxin oxidoreductase core domain II	-	-	1.2.7.7	ko:K00186	ko00280,ko01100,map00280,map01100	-	R07160,R08566,R08567	RC00004,RC02833,RC02856	br01601,ko00000,ko00001,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_3105809_6	234267.Acid_1872	1.634e-24	104.0	COG1146@1|root,COG1146@2|Bacteria,3Y8V9@57723|Acidobacteria	57723|Acidobacteria	C	4Fe-4S dicluster domain	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_3105809_0	1267535.KB906767_gene2870	4.024e-240	757.0	COG2217@1|root,COG2217@2|Bacteria	2|Bacteria	P	Heavy metal translocating P-type atpase	cadA	-	-	-	-	-	-	-	-	-	-	-	E1-E2_ATPase,Hemerythrin,Hydrolase
HKD1_k127_3105809_5	1122135.KB893135_gene868	3.126e-78	268.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_3105809_7	1454007.JAUG01000087_gene3940	1.104e-20	99.0	COG3467@1|root,COG3467@2|Bacteria,4NQFR@976|Bacteroidetes,1ITPB@117747|Sphingobacteriia	976|Bacteroidetes	S	SPTR Pyridoxamine 5'-phosphate oxidase-related FMN-binding protein	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD1_k127_3105809_4	211165.AJLN01000094_gene1126	1.74e-117	395.0	COG2202@1|root,COG2204@1|root,COG4191@1|root,COG5278@1|root,COG2202@2|Bacteria,COG2204@2|Bacteria,COG4191@2|Bacteria,COG5278@2|Bacteria,1GK1J@1117|Cyanobacteria,1JKBT@1189|Stigonemataceae	1117|Cyanobacteria	T	CHASE3 domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,PAS_9,Response_reg
HKD1_k127_3105809_3	269799.Gmet_0555	4.044e-138	454.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WKJX@28221|Deltaproteobacteria,43S25@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Domains REC, sigma54 interaction, HTH8	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3136975_2	481448.Minf_1359	2.217e-130	425.0	COG1494@1|root,COG1494@2|Bacteria,46THC@74201|Verrucomicrobia,37H8X@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD1_k127_3136975_5	497964.CfE428DRAFT_3494	1.639e-92	310.0	COG3880@1|root,COG3880@2|Bacteria	2|Bacteria	E	PFAM UvrB UvrC protein	omcN	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase,GSu_C4xC__C2xCH,Paired_CXXCH_1,UVR
HKD1_k127_3136975_3	497964.CfE428DRAFT_2617	2.863e-120	400.0	COG4974@1|root,COG4974@2|Bacteria,46SSD@74201|Verrucomicrobia	74201|Verrucomicrobia	L	integrase domain protein SAM domain protein	-	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_3136975_15	1403819.BATR01000022_gene762	2.719e-40	153.0	COG0838@1|root,COG0838@2|Bacteria,46T33@74201|Verrucomicrobia,2IUK0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_3136975_0	497964.CfE428DRAFT_2547	3.194e-180	572.0	COG0463@1|root,COG0463@2|Bacteria,46SXD@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_3136975_17	215803.DB30_5801	1.309e-36	155.0	2EJZM@1|root,33DQ6@2|Bacteria,1N7GI@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3136975_1	497964.CfE428DRAFT_2549	3.497e-147	472.0	COG2605@1|root,COG2605@2|Bacteria,46UPC@74201|Verrucomicrobia	74201|Verrucomicrobia	H	GHMP kinase domain protein	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_3136975_7	497964.CfE428DRAFT_2550	5.282e-91	305.0	COG1208@1|root,COG1208@2|Bacteria,46UUZ@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Nucleotidyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transferase
HKD1_k127_3136975_6	497964.CfE428DRAFT_2551	1.337e-91	304.0	COG0279@1|root,COG0279@2|Bacteria,46TRG@74201|Verrucomicrobia	74201|Verrucomicrobia	G	SIS domain	-	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	SIS_2
HKD1_k127_3136975_10	497964.CfE428DRAFT_2552	1.387e-56	208.0	COG0241@1|root,COG0241@2|Bacteria,46T3Q@74201|Verrucomicrobia	74201|Verrucomicrobia	E	hydrolase, HAD-superfamily, subfamily IIIA	-	-	3.1.3.82,3.1.3.83	ko:K03273	ko00540,ko01100,map00540,map01100	M00064	R05647,R09771	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	HAD_2,Hydrolase_like
HKD1_k127_3136975_4	497964.CfE428DRAFT_4962	1.383e-94	316.0	COG0176@1|root,COG0176@2|Bacteria,46TNS@74201|Verrucomicrobia	74201|Verrucomicrobia	H	PFAM Transaldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_3136975_19	1242864.D187_010175	2.746e-11	76.0	COG1807@1|root,COG1807@2|Bacteria,1Q2FK@1224|Proteobacteria,4381I@68525|delta/epsilon subdivisions,2X3BM@28221|Deltaproteobacteria,2YUUG@29|Myxococcales	28221|Deltaproteobacteria	M	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3136975_11	1304874.JAFY01000002_gene694	3.799e-52	212.0	COG5427@1|root,COG5427@2|Bacteria,3TC17@508458|Synergistetes	508458|Synergistetes	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3136975_14	521011.Mpal_1474	9.978e-42	178.0	COG0614@1|root,arCOG03561@1|root,arCOG03561@2157|Archaea,arCOG03611@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
HKD1_k127_3136975_12	1121448.DGI_0529	2.353e-44	186.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD1_k127_3136975_18	1121335.Clst_1370	2.082e-23	117.0	COG5427@1|root,COG5427@2|Bacteria,1UXXM@1239|Firmicutes,24EF9@186801|Clostridia,3WHFN@541000|Ruminococcaceae	186801|Clostridia	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3136975_13	1121448.DGI_0529	8.187e-43	179.0	COG3391@1|root,COG3391@2|Bacteria,1NT97@1224|Proteobacteria,42RMY@68525|delta/epsilon subdivisions,2WNJD@28221|Deltaproteobacteria,2MF83@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL
HKD1_k127_3136975_20	1415779.JOMH01000001_gene124	1.35e-06	61.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_22,PMT,PMT_2
HKD1_k127_3152399_34	264203.ZMO1976	0.0003888	47.0	2BX7C@1|root,2ZB4P@2|Bacteria,1NSDF@1224|Proteobacteria,2U03Z@28211|Alphaproteobacteria,2KEX4@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3152399_30	234267.Acid_6308	2.768e-28	128.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_3152399_20	697303.Thewi_2114	6.911e-67	234.0	COG5012@1|root,COG5012@2|Bacteria,1V1P0@1239|Firmicutes,24G08@186801|Clostridia,42FJI@68295|Thermoanaerobacterales	186801|Clostridia	S	Methionine synthase B12-binding module cap domain protein	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2
HKD1_k127_3152399_13	1499967.BAYZ01000027_gene1815	4.947e-109	365.0	COG0407@1|root,COG0407@2|Bacteria	2|Bacteria	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	-	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD1_k127_3152399_1	502025.Hoch_4458	3.197e-232	735.0	COG0517@1|root,COG2170@1|root,COG0517@2|Bacteria,COG2170@2|Bacteria,1MXET@1224|Proteobacteria,43BYB@68525|delta/epsilon subdivisions,2X798@28221|Deltaproteobacteria,2YX02@29|Myxococcales	28221|Deltaproteobacteria	S	glutamate--cysteine ligase	-	-	-	-	-	-	-	-	-	-	-	-	GCS2
HKD1_k127_3152399_2	869210.Marky_1642	5.702e-223	699.0	COG3033@1|root,COG3033@2|Bacteria,1WM62@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_3152399_18	509635.N824_24055	4.103e-70	243.0	COG2335@1|root,COG2335@2|Bacteria,4NMAH@976|Bacteroidetes,1IS48@117747|Sphingobacteriia	976|Bacteroidetes	M	Four repeated domains in the Fasciclin I family of proteins, present in many other contexts.	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_3152399_29	932678.THERU_02135	9.38e-35	138.0	COG2346@1|root,COG2346@2|Bacteria,2G5AF@200783|Aquificae	200783|Aquificae	S	Bacterial-like globin	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	Bac_globin
HKD1_k127_3152399_27	258594.RPA0568	2.825e-52	192.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria,3JT7M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Metallo-beta-lactamase superfamily	ycbL	GO:0003674,GO:0003824,GO:0004416,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006081,GO:0006082,GO:0006089,GO:0008150,GO:0008152,GO:0009056,GO:0009438,GO:0009987,GO:0016787,GO:0016788,GO:0016790,GO:0019243,GO:0019752,GO:0032787,GO:0042180,GO:0042182,GO:0043436,GO:0044237,GO:0044248,GO:0044281,GO:0044282,GO:0044424,GO:0044444,GO:0044464,GO:0046185,GO:0051596,GO:0061727,GO:0071704,GO:1901575,GO:1901615	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_3152399_3	671143.DAMO_2498	2.174e-156	500.0	COG1180@1|root,COG1180@2|Bacteria,2NP82@2323|unclassified Bacteria	2|Bacteria	O	Radical SAM superfamily	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_3152399_33	639030.JHVA01000001_gene2268	0.0003251	52.0	COG4994@1|root,COG4994@2|Bacteria,3Y8YB@57723|Acidobacteria,2JNQS@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_3152399_22	204669.Acid345_3751	2.676e-63	230.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JNJP@204432|Acidobacteriia	57723|Acidobacteria	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_3152399_0	502025.Hoch_1577	7.672e-248	796.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,1P64D@1224|Proteobacteria,439PY@68525|delta/epsilon subdivisions,2X51T@28221|Deltaproteobacteria,2YZZT@29|Myxococcales	28221|Deltaproteobacteria	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_3152399_23	234267.Acid_5219	6.889e-58	207.0	COG1595@1|root,COG1595@2|Bacteria,3Y7YB@57723|Acidobacteria	2|Bacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_3152399_32	1122604.JONR01000049_gene754	3.579e-25	111.0	2DP2V@1|root,330AH@2|Bacteria,1R3EE@1224|Proteobacteria,1T670@1236|Gammaproteobacteria,1XAWE@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF3455)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3455
HKD1_k127_3152399_10	747365.Thena_1520	2.434e-126	418.0	COG2801@1|root,COG2801@2|Bacteria,1UINX@1239|Firmicutes,24BC3@186801|Clostridia	186801|Clostridia	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_3152399_26	643648.Slip_0610	3.79e-54	204.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia	186801|Clostridia	E	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD1_k127_3152399_25	273068.TTE2139	1.741e-56	203.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,42G66@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD1_k127_3152399_11	56780.SYN_01792	8.929e-117	392.0	COG0141@1|root,COG0141@2|Bacteria,1MUUF@1224|Proteobacteria,42M3R@68525|delta/epsilon subdivisions,2WJGT@28221|Deltaproteobacteria,2MQCY@213462|Syntrophobacterales	28221|Deltaproteobacteria	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	GO:0000105,GO:0003674,GO:0003824,GO:0004399,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006547,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0052803,GO:0055114,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_3152399_17	760568.Desku_1692	2.544e-71	255.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,2606W@186807|Peptococcaceae	186801|Clostridia	E	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3152399_19	1286171.EAL2_c14120	6.264e-67	233.0	COG0131@1|root,COG0131@2|Bacteria,1TRH7@1239|Firmicutes,247WC@186801|Clostridia,25VZA@186806|Eubacteriaceae	186801|Clostridia	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD1_k127_3152399_24	1121468.AUBR01000017_gene2363	1.046e-57	207.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,42G87@68295|Thermoanaerobacterales	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_3152399_14	926569.ANT_23700	2.632e-99	329.0	COG0107@1|root,COG0107@2|Bacteria,2G5Y2@200795|Chloroflexi	200795|Chloroflexi	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	GO:0000107,GO:0003674,GO:0003824,GO:0016740,GO:0016757,GO:0016763	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_3152399_16	562970.Btus_2167	5.537e-78	267.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,4HA9R@91061|Bacilli,279NY@186823|Alicyclobacillaceae	91061|Bacilli	E	Histidine biosynthesis bifunctional protein HisIE	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS14110,iYO844.BSU34860	PRA-CH,PRA-PH
HKD1_k127_3152399_15	671143.DAMO_0013	2.635e-98	329.0	COG0483@1|root,COG0483@2|Bacteria,2NQAS@2323|unclassified Bacteria	2|Bacteria	G	Inositol monophosphatase family	hisN	-	3.1.3.15,3.1.3.25	ko:K01092,ko:K05602	ko00340,ko00521,ko00562,ko01100,ko01110,ko01230,ko04070,map00340,map00521,map00562,map01100,map01110,map01230,map04070	M00026,M00131	R01185,R01186,R01187,R03013	RC00017,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_3152399_21	429009.Adeg_0316	2.053e-65	231.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,42G05@68295|Thermoanaerobacterales	186801|Clostridia	E	TIGRFAM phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_3152399_12	1260356.D920_02670	6.744e-114	377.0	COG1087@1|root,COG1087@2|Bacteria,1TQ7N@1239|Firmicutes,4H9U5@91061|Bacilli,4B0B9@81852|Enterococcaceae	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_3152399_5	880073.Calab_0031	2.897e-149	483.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD1_k127_3152399_7	485913.Krac_4655	2.281e-140	464.0	COG0153@1|root,COG0153@2|Bacteria,2G6CE@200795|Chloroflexi	200795|Chloroflexi	F	Belongs to the GHMP kinase family. GalK subfamily	-	-	2.7.1.6	ko:K00849	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00554,M00632	R01092	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	GHMP_kinases_C,GHMP_kinases_N,GalKase_gal_bdg
HKD1_k127_3152399_8	765420.OSCT_1871	9.82e-133	433.0	COG0483@1|root,COG0483@2|Bacteria,2G88V@200795|Chloroflexi	200795|Chloroflexi	G	inositol monophosphate 1-phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3152399_4	485913.Krac_4653	2.936e-153	490.0	COG1085@1|root,COG1085@2|Bacteria,2G6K5@200795|Chloroflexi	200795|Chloroflexi	H	TIGRFAM galactose-1-phosphate uridylyltransferase	galT	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_tr_C,GalP_UDP_transf
HKD1_k127_3152399_9	1396141.BATP01000038_gene1207	1.08e-129	422.0	COG1172@1|root,COG1172@2|Bacteria,46V1Z@74201|Verrucomicrobia,2IVHK@203494|Verrucomicrobiae	203494|Verrucomicrobiae	G	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_3152399_6	1089551.KE386572_gene1377	7.298e-144	467.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,2TQJV@28211|Alphaproteobacteria,4BR8I@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	ATPases associated with a variety of cellular activities	alsA	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD1_k127_3177648_12	1356852.N008_04440	5.286e-61	222.0	COG3361@1|root,COG3361@2|Bacteria,4NITY@976|Bacteroidetes	976|Bacteroidetes	S	conserved protein (COG2071)	-	-	-	ko:K09166	-	-	-	-	ko00000	-	-	-	DUF2071
HKD1_k127_3177648_10	335543.Sfum_3563	2.836e-70	246.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_3177648_17	1198114.AciX9_2795	2.935e-29	130.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria,2JIT1@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_3177648_3	234267.Acid_3935	8.675e-119	398.0	COG1181@1|root,COG1181@2|Bacteria,3Y9AM@57723|Acidobacteria	57723|Acidobacteria	M	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_4
HKD1_k127_3177648_0	518766.Rmar_2202	6.547e-187	608.0	COG0318@1|root,COG0318@2|Bacteria,4NFPF@976|Bacteroidetes,1FJSN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	IQ	AMP-binding enzyme C-terminal domain	fadD	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C
HKD1_k127_3177648_16	1267534.KB906755_gene4760	1.309e-32	131.0	COG3631@1|root,COG3631@2|Bacteria	2|Bacteria	S	light absorption	-	-	5.3.3.1	ko:K01822	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	M00107,M00110	R01837,R02216,R02499,R02840,R03327,R04163,R04678,R04849,R09955	RC00146,RC00762	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4440,SnoaL_2
HKD1_k127_3177648_7	1122599.AUGR01000014_gene587	8.666e-90	313.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,1RMI2@1236|Gammaproteobacteria,1XHK6@135619|Oceanospirillales	1236|Gammaproteobacteria	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_3177648_15	1121413.JMKT01000001_gene1686	1.812e-41	158.0	COG0399@1|root,COG0399@2|Bacteria,1N0QW@1224|Proteobacteria,42W70@68525|delta/epsilon subdivisions,2X245@28221|Deltaproteobacteria,2MFSC@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_3177648_8	234267.Acid_4783	1.802e-89	314.0	COG0531@1|root,COG0531@2|Bacteria,3Y2T1@57723|Acidobacteria	57723|Acidobacteria	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_3177648_9	118163.Ple7327_2631	1.592e-72	257.0	COG2367@1|root,COG2367@2|Bacteria,1G0DG@1117|Cyanobacteria,3VI6T@52604|Pleurocapsales	1117|Cyanobacteria	V	Beta-lactamase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
HKD1_k127_3177648_2	1267535.KB906767_gene1522	2.723e-144	461.0	COG5285@1|root,COG5285@2|Bacteria	2|Bacteria	Q	dioxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HKD1_k127_3177648_6	324602.Caur_2455	5.347e-91	307.0	COG2162@1|root,COG2162@2|Bacteria,2G8H7@200795|Chloroflexi	200795|Chloroflexi	H	Belongs to the arylamine N-acetyltransferase family	-	-	2.3.1.118	ko:K00675	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_2
HKD1_k127_3177648_22	316056.RPC_4541	2.616e-10	68.0	COG0848@1|root,COG0848@2|Bacteria,1RDJZ@1224|Proteobacteria,2U77T@28211|Alphaproteobacteria,3JY9W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	Biopolymer transport protein ExbD/TolR	exbD	-	-	ko:K03559,ko:K03560	-	-	-	-	ko00000,ko02000	1.A.30.2.1,1.A.30.2.2	-	-	ExbD
HKD1_k127_3177648_1	234267.Acid_3371	6.006e-161	521.0	COG0265@1|root,COG0265@2|Bacteria,3Y2WB@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3177648_23	983544.Lacal_0442	7.015e-06	52.0	2DX2S@1|root,3433P@2|Bacteria,4P4U7@976|Bacteroidetes,1I9PF@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177648_4	1278073.MYSTI_05436	6.746e-114	376.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,42U5B@68525|delta/epsilon subdivisions,2WQVN@28221|Deltaproteobacteria,2YWFF@29|Myxococcales	28221|Deltaproteobacteria	L	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_3177648_13	1144275.COCOR_07396	6.164e-46	181.0	COG2898@1|root,COG2898@2|Bacteria,1N1JA@1224|Proteobacteria,437UA@68525|delta/epsilon subdivisions,2WYP1@28221|Deltaproteobacteria,2YU44@29|Myxococcales	28221|Deltaproteobacteria	S	Uncharacterised conserved protein (DUF2156)	-	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156
HKD1_k127_3177648_11	1173024.KI912148_gene4396	9.134e-62	224.0	COG2267@1|root,COG2267@2|Bacteria,1GQJU@1117|Cyanobacteria	1117|Cyanobacteria	I	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_3177648_18	945713.IALB_2992	8.546e-25	109.0	COG0517@1|root,COG0517@2|Bacteria	2|Bacteria	S	IMP dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_3177648_5	941449.dsx2_0833	1.114e-110	371.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,42QV3@68525|delta/epsilon subdivisions,2WMT2@28221|Deltaproteobacteria,2MA5X@213115|Desulfovibrionales	28221|Deltaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	GSDH
HKD1_k127_3177648_21	298653.Franean1_0011	9.194e-11	71.0	COG0500@1|root,COG2226@2|Bacteria,2H38T@201174|Actinobacteria,4EU2T@85013|Frankiales	201174|Actinobacteria	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3177648_19	522306.CAP2UW1_3067	5e-20	101.0	2A20V@1|root,30QAU@2|Bacteria,1RDQH@1224|Proteobacteria,2VQZV@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177648_20	292459.STH852	8.498e-19	100.0	COG0741@1|root,COG0741@2|Bacteria,1V6K4@1239|Firmicutes,24JB5@186801|Clostridia	186801|Clostridia	M	transglycosylase	slt	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD1_k127_3177648_14	682795.AciX8_2195	2.439e-43	164.0	COG1765@1|root,COG1765@2|Bacteria,3Y563@57723|Acidobacteria,2JJUX@204432|Acidobacteriia	204432|Acidobacteriia	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD1_k127_3188942_4	1267533.KB906739_gene2747	1.424e-19	94.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria,2JIF7@204432|Acidobacteriia	204432|Acidobacteriia	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_3188942_1	1192034.CAP_6355	2.3e-32	130.0	COG3411@1|root,COG3411@2|Bacteria,1RM68@1224|Proteobacteria,42TUK@68525|delta/epsilon subdivisions,2WQGU@28221|Deltaproteobacteria,2YVQK@29|Myxococcales	28221|Deltaproteobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3188942_0	204669.Acid345_3332	1.378e-40	159.0	COG2318@1|root,COG2318@2|Bacteria,3Y4TP@57723|Acidobacteria,2JJPR@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_3188942_3	357808.RoseRS_0379	7.823e-20	91.0	COG5499@1|root,COG5499@2|Bacteria,2GB4I@200795|Chloroflexi,377WX@32061|Chloroflexia	32061|Chloroflexia	K	transcription regulator containing HTH domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3188942_2	395492.Rleg2_3602	2.545e-32	137.0	2D2IW@1|root,32TCX@2|Bacteria,1N4MH@1224|Proteobacteria,2U5DM@28211|Alphaproteobacteria,4BKZQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1353)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
HKD1_k127_3196365_11	1385935.N836_30695	3.475e-14	87.0	COG2133@1|root,COG2755@1|root,COG2133@2|Bacteria,COG2755@2|Bacteria,1G70I@1117|Cyanobacteria	1117|Cyanobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_3196365_10	40571.JOEA01000017_gene365	9.571e-16	92.0	COG3511@1|root,COG3511@2|Bacteria,2GQGM@201174|Actinobacteria	201174|Actinobacteria	M	hydrolase, family 65, central catalytic	-	-	3.1.3.64	ko:K21302	ko00562,ko01100,ko05152,map00562,map01100,map05152	-	-	-	ko00000,ko00001,ko01000	-	-	-	Phosphoesterase
HKD1_k127_3196365_6	1125863.JAFN01000001_gene2355	4.551e-37	162.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,1PFJ7@1224|Proteobacteria,42WVE@68525|delta/epsilon subdivisions	1224|Proteobacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3196365_4	945713.IALB_2758	2.799e-59	213.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_3196365_1	1356852.N008_05325	1.655e-113	404.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NK8Q@976|Bacteroidetes,47KVN@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HKD1_k127_3196365_0	234267.Acid_2573	2.358e-153	498.0	COG0541@1|root,COG0541@2|Bacteria,3Y3AU@57723|Acidobacteria	57723|Acidobacteria	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_3196365_8	383372.Rcas_1666	2.508e-22	100.0	COG0228@1|root,COG0228@2|Bacteria,2G7A3@200795|Chloroflexi,377I8@32061|Chloroflexia	32061|Chloroflexia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0019538,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044446,GO:0044464,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD1_k127_3196365_9	1123371.ATXH01000031_gene2168	3.527e-17	85.0	COG1837@1|root,COG1837@2|Bacteria,2GI1Q@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Belongs to the UPF0109 family	-	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD1_k127_3196365_7	1267533.KB906735_gene4712	9.634e-29	122.0	COG0806@1|root,COG0806@2|Bacteria,3Y51G@57723|Acidobacteria,2JJGA@204432|Acidobacteriia	204432|Acidobacteriia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD1_k127_3196365_3	401053.AciPR4_2149	6.336e-83	281.0	COG0336@1|root,COG0336@2|Bacteria,3Y3CS@57723|Acidobacteria,2JHUJ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD1_k127_3196365_5	243231.GSU0648	2.274e-41	156.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,42TMU@68525|delta/epsilon subdivisions,2WQ67@28221|Deltaproteobacteria,43UYA@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD1_k127_3196365_2	234267.Acid_6231	5.555e-84	293.0	COG0438@1|root,COG0438@2|Bacteria,3Y58K@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3196365_12	1123288.SOV_2c10690	7.907e-05	57.0	2DBB8@1|root,2Z867@2|Bacteria,1V7Q5@1239|Firmicutes,4H63P@909932|Negativicutes	909932|Negativicutes	S	Protein of unknown function (DUF3383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3383
HKD1_k127_3257766_0	452637.Oter_4313	1.499e-230	722.0	COG2211@1|root,COG2211@2|Bacteria	2|Bacteria	G	Major facilitator Superfamily	xylP	-	-	ko:K03292,ko:K16248	-	-	-	-	ko00000,ko02000	2.A.2	-	-	MFS_2
HKD1_k127_3257766_16	234267.Acid_2679	2.77e-25	106.0	COG1472@1|root,COG1472@2|Bacteria,3Y3QE@57723|Acidobacteria	57723|Acidobacteria	G	hydrolase, family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_3257766_4	1282361.ABAC402_06555	6.084e-154	492.0	COG0657@1|root,COG0657@2|Bacteria,1R79Q@1224|Proteobacteria,2U6W0@28211|Alphaproteobacteria,2KIDH@204458|Caulobacterales	204458|Caulobacterales	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD1_k127_3257766_17	1347368.HG964409_gene7369	1.73e-24	104.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_3257766_14	335543.Sfum_0084	6.041e-31	124.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MS96@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3257766_8	857087.Metme_2467	2.707e-90	302.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,1RP0B@1236|Gammaproteobacteria,1XDPT@135618|Methylococcales	135618|Methylococcales	K	SMART HTH transcriptional regulator, Crp	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
HKD1_k127_3257766_11	309801.trd_1922	4.285e-47	194.0	COG0028@1|root,COG3055@1|root,COG0028@2|Bacteria,COG3055@2|Bacteria,2GBSZ@200795|Chloroflexi,27ZA5@189775|Thermomicrobia	189775|Thermomicrobia	EH	Belongs to the TPP enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3257766_13	1123073.KB899241_gene1790	1.048e-31	144.0	COG3210@1|root,COG3210@2|Bacteria,1QZXD@1224|Proteobacteria,1T4BM@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3257766_15	671143.DAMO_1421	4.161e-28	127.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD1_k127_3257766_21	243231.GSU1285	0.0003759	49.0	COG5002@1|root,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K20974	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF2222,DUF3365,HAMP,HATPase_c,HisKA,HisKA_7TM,Hpt,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_3
HKD1_k127_3257766_6	1267533.KB906738_gene2031	1.209e-117	385.0	COG1398@1|root,COG1398@2|Bacteria,3Y3F9@57723|Acidobacteria,2JHWH@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD1_k127_3257766_3	311424.DhcVS_1063	3.144e-156	508.0	COG1032@1|root,COG1032@2|Bacteria,2G6X0@200795|Chloroflexi,34D6J@301297|Dehalococcoidia	301297|Dehalococcoidia	C	B12 binding domain	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_3257766_19	927658.AJUM01000034_gene105	2.61e-07	53.0	COG1741@1|root,COG1741@2|Bacteria,4NFZD@976|Bacteroidetes,2FQT2@200643|Bacteroidia	976|Bacteroidetes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_3257766_10	266117.Rxyl_2819	1.776e-50	186.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_11,HTH_20,HTH_24,HTH_5,MarR_2
HKD1_k127_3257766_12	1386089.N865_10085	2.553e-36	141.0	2BVXR@1|root,32IG2@2|Bacteria,2IMT1@201174|Actinobacteria,4FGU2@85021|Intrasporangiaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DoxX
HKD1_k127_3257766_20	118161.KB235919_gene6283	0.0001541	48.0	COG0446@1|root,COG2146@1|root,COG0446@2|Bacteria,COG2146@2|Bacteria,1G40A@1117|Cyanobacteria,3VJDA@52604|Pleurocapsales	1117|Cyanobacteria	P	Reductase C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Reductase_C,Rieske
HKD1_k127_3257766_1	748247.AZKH_2015	2.263e-189	602.0	COG1858@1|root,COG1858@2|Bacteria,1N4E1@1224|Proteobacteria,2VVJQ@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C
HKD1_k127_3257766_7	1379698.RBG1_1C00001G0607	7.116e-96	335.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_3257766_9	204669.Acid345_1052	6.022e-72	264.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_3257766_5	204669.Acid345_1052	1.465e-142	481.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_3257766_2	204669.Acid345_1052	4.188e-167	556.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_3257766_18	234267.Acid_7572	3.329e-11	65.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_3266519_20	1183438.GKIL_2157	2.936e-94	322.0	COG4076@1|root,COG4076@2|Bacteria,1G4RK@1117|Cyanobacteria	1117|Cyanobacteria	J	PRMT5 arginine-N-methyltransferase	-	-	2.1.1.319	ko:K11434	ko04068,ko04922,map04068,map04922	-	R11216,R11217,R11219	RC00003,RC02120,RC03388,RC03390	ko00000,ko00001,ko01000,ko03036	-	-	-	PRMT5_C,PrmA
HKD1_k127_3266519_47	1170562.Cal6303_0849	6.117e-19	92.0	2BN1K@1|root,32GMS@2|Bacteria,1GKE8@1117|Cyanobacteria,1HT1Y@1161|Nostocales	1117|Cyanobacteria	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
HKD1_k127_3266519_39	865937.Gilli_0789	3.452e-30	141.0	COG3420@1|root,COG4932@1|root,COG3420@2|Bacteria,COG4932@2|Bacteria,4PP4R@976|Bacteroidetes,1ICSM@117743|Flavobacteriia,2P78Q@244698|Gillisia	976|Bacteroidetes	M	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_45	1121904.ARBP01000006_gene3681	4.673e-22	114.0	COG3419@1|root,COG4447@1|root,COG4932@1|root,COG5184@1|root,COG3419@2|Bacteria,COG4447@2|Bacteria,COG4932@2|Bacteria,COG5184@2|Bacteria,4NNEI@976|Bacteroidetes	976|Bacteroidetes	DZ	Putative metal-binding motif	-	-	-	-	-	-	-	-	-	-	-	-	Cu-binding_MopE,DUF1566
HKD1_k127_3266519_49	1120965.AUBV01000015_gene1042	4.599e-11	78.0	COG3291@1|root,COG3291@2|Bacteria,4P401@976|Bacteroidetes	976|Bacteroidetes	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_33	215803.DB30_2315	4.724e-36	160.0	COG1520@1|root,COG3055@1|root,COG4676@1|root,COG1520@2|Bacteria,COG3055@2|Bacteria,COG4676@2|Bacteria,1NZI5@1224|Proteobacteria,43AH4@68525|delta/epsilon subdivisions,2X5X4@28221|Deltaproteobacteria,2Z37E@29|Myxococcales	1224|Proteobacteria	S	Kelch motif	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Kelch_1,Kelch_4,PKD,UPF0560
HKD1_k127_3266519_50	234267.Acid_3298	2.805e-10	68.0	COG2885@1|root,COG2885@2|Bacteria,3Y8DM@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_7	443144.GM21_2582	9.91e-138	471.0	COG1086@1|root,COG1086@2|Bacteria,1MWKY@1224|Proteobacteria,42MMR@68525|delta/epsilon subdivisions,2WJEB@28221|Deltaproteobacteria,43TVP@69541|Desulfuromonadales	28221|Deltaproteobacteria	GM	Polysaccharide biosynthesis protein CapD	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
HKD1_k127_3266519_10	1340493.JNIF01000004_gene640	2.163e-124	411.0	COG0399@1|root,COG0399@2|Bacteria,3Y2QT@57723|Acidobacteria	57723|Acidobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_3266519_34	330214.NIDE0884	7.844e-36	147.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	rhiI	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0009273,GO:0009987,GO:0016020,GO:0016043,GO:0016740,GO:0016741,GO:0022607,GO:0032259,GO:0042546,GO:0044085,GO:0044464,GO:0071554,GO:0071766,GO:0071770,GO:0071840,GO:0071944	-	ko:K15471	-	-	-	-	ko00000,ko01000,ko01008	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_3266519_51	1304872.JAGC01000003_gene2387	2.817e-10	74.0	COG5305@1|root,COG5305@2|Bacteria,1R9UF@1224|Proteobacteria,43EPC@68525|delta/epsilon subdivisions,2X196@28221|Deltaproteobacteria,2MEI2@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_3266519_17	864069.MicloDRAFT_00025890	1.288e-98	332.0	COG1215@1|root,COG1215@2|Bacteria,1NDPE@1224|Proteobacteria,2TSCT@28211|Alphaproteobacteria,1JUA4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	M	PFAM Glycosyl transferase family 2	exoA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K16557	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_3266519_31	439481.Aboo_0277	1.051e-41	167.0	COG0438@1|root,arCOG01403@2157|Archaea	2157|Archaea	M	PFAM Glycosyl transferase, group 1	-	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K12996	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	DUF1972,Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_3266519_32	159450.NH14_00775	2.379e-39	162.0	COG0438@1|root,COG0438@2|Bacteria,1MVA7@1224|Proteobacteria,2VM0Z@28216|Betaproteobacteria,1K0MP@119060|Burkholderiaceae	28216|Betaproteobacteria	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_3266519_27	435591.BDI_3229	4.301e-52	193.0	COG0463@1|root,COG0463@2|Bacteria,4NGYU@976|Bacteroidetes	976|Bacteroidetes	M	Glycosyl transferase family 2	-	-	-	ko:K12984	-	-	-	-	ko00000,ko01000,ko01003,ko01005,ko02000	4.D.1.3	GT2	-	Glycos_transf_2
HKD1_k127_3266519_48	1385518.N798_14500	3.345e-16	88.0	COG0500@1|root,COG2226@2|Bacteria,2IMHF@201174|Actinobacteria,4FIRA@85021|Intrasporangiaceae	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_3266519_35	435591.BDI_3231	2.845e-34	146.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	capM	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_3266519_57	1128421.JAGA01000002_gene1600	7.811e-05	55.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723,PMT,PMT_2
HKD1_k127_3266519_46	1380347.JNII01000005_gene3700	2.239e-20	104.0	COG0438@1|root,COG0438@2|Bacteria,2GMXE@201174|Actinobacteria,4EUXQ@85013|Frankiales	201174|Actinobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_3266519_41	1408424.JHYI01000004_gene3471	2.703e-29	132.0	COG0438@1|root,COG1543@1|root,COG0438@2|Bacteria,COG1543@2|Bacteria,1TPFX@1239|Firmicutes,4HD14@91061|Bacilli,1ZPVT@1386|Bacillus	91061|Bacilli	M	Belongs to the glycosyl hydrolase 57 family	-	-	2.4.1.18	ko:K16149	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000	-	GH57	-	DUF1957,Glyco_hydro_57,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_3266519_55	269799.Gmet_0243	1.237e-05	58.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HKD1_k127_3266519_26	395961.Cyan7425_1956	5.345e-54	202.0	COG1216@1|root,COG1216@2|Bacteria,1G346@1117|Cyanobacteria,3KFQB@43988|Cyanothece	1117|Cyanobacteria	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_3266519_24	443143.GM18_0952	2.702e-61	226.0	COG0438@1|root,COG0438@2|Bacteria,1MWVX@1224|Proteobacteria,42WEG@68525|delta/epsilon subdivisions,2WWQ8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glycos_transf_1
HKD1_k127_3266519_43	1227352.C173_08546	2.179e-27	122.0	COG0457@1|root,COG2227@1|root,COG0457@2|Bacteria,COG2227@2|Bacteria,1W0ME@1239|Firmicutes,4ITZA@91061|Bacilli,26X2W@186822|Paenibacillaceae	91061|Bacilli	H	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3266519_11	330214.NIDE3332	1.506e-122	406.0	COG1134@1|root,COG1134@2|Bacteria,3J142@40117|Nitrospirae	2|Bacteria	GM	Evidence 2b Function of strongly homologous gene	-	-	3.6.3.38	ko:K01990,ko:K09689,ko:K09691	ko02010,map02010	M00249,M00250,M00254	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.101,3.A.1.103	-	-	ABC_tran,Wzt_C
HKD1_k127_3266519_18	395494.Galf_2854	5.566e-98	331.0	COG0382@1|root,COG0382@2|Bacteria,1MXCM@1224|Proteobacteria,2VKY4@28216|Betaproteobacteria	28216|Betaproteobacteria	H	PFAM UbiA prenyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	UbiA
HKD1_k127_3266519_9	237368.SCABRO_01358	6.348e-130	422.0	COG1682@1|root,COG1682@2|Bacteria,2IYXC@203682|Planctomycetes	203682|Planctomycetes	U	COG1682 ABC-type polysaccharide polyol phosphate export systems, permease component	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HKD1_k127_3266519_3	56110.Oscil6304_1714	5.276e-182	578.0	COG0399@1|root,COG0399@2|Bacteria,1G4PM@1117|Cyanobacteria,1HFC1@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM DegT DnrJ EryC1 StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_3266519_19	682795.AciX8_1492	2.547e-96	346.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,3Y2V7@57723|Acidobacteria,2JIYH@204432|Acidobacteriia	57723|Acidobacteria	D	G-rich domain on putative tyrosine kinase	-	-	2.7.10.1	ko:K08252,ko:K16554	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,Wzz
HKD1_k127_3266519_42	237368.SCABRO_01529	3.507e-28	126.0	COG1596@1|root,COG1596@2|Bacteria,2J1I5@203682|Planctomycetes	203682|Planctomycetes	M	SLBB domain	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_3266519_38	204669.Acid345_4197	1.701e-30	139.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria,2JI3J@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_56	9986.ENSOCUP00000017055	5.876e-05	55.0	KOG1125@1|root,KOG1125@2759|Eukaryota,38C1T@33154|Opisthokonta,3BFN9@33208|Metazoa,3D0KU@33213|Bilateria,480FS@7711|Chordata,491J1@7742|Vertebrata,3J27Q@40674|Mammalia,35E3G@314146|Euarchontoglires	33208|Metazoa	S	peroxisome matrix targeting signal-1 binding	PEX5	GO:0000038,GO:0000268,GO:0001764,GO:0002119,GO:0002164,GO:0003008,GO:0003674,GO:0005048,GO:0005052,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005777,GO:0005778,GO:0005782,GO:0005794,GO:0005829,GO:0006082,GO:0006464,GO:0006605,GO:0006612,GO:0006625,GO:0006629,GO:0006631,GO:0006635,GO:0006807,GO:0006810,GO:0006886,GO:0006928,GO:0006996,GO:0007005,GO:0007006,GO:0007029,GO:0007031,GO:0007275,GO:0007399,GO:0007417,GO:0007420,GO:0008022,GO:0008104,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009791,GO:0009987,GO:0010256,GO:0012505,GO:0015031,GO:0015833,GO:0015919,GO:0016020,GO:0016042,GO:0016043,GO:0016054,GO:0016477,GO:0016558,GO:0016560,GO:0016561,GO:0016567,GO:0017038,GO:0019395,GO:0019538,GO:0019752,GO:0019899,GO:0021537,GO:0021543,GO:0021795,GO:0021885,GO:0021895,GO:0021953,GO:0021987,GO:0022008,GO:0022029,GO:0022607,GO:0030154,GO:0030182,GO:0030258,GO:0030900,GO:0031090,GO:0031267,GO:0031333,GO:0031903,GO:0031907,GO:0031974,GO:0032446,GO:0032459,GO:0032460,GO:0032462,GO:0032463,GO:0032501,GO:0032502,GO:0032787,GO:0032991,GO:0033036,GO:0033218,GO:0033365,GO:0034440,GO:0034613,GO:0036211,GO:0040008,GO:0040011,GO:0040014,GO:0040018,GO:0042221,GO:0042277,GO:0042493,GO:0042579,GO:0042886,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043254,GO:0043412,GO:0043436,GO:0043574,GO:0043933,GO:0044085,GO:0044087,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044260,GO:0044267,GO:0044281,GO:0044282,GO:0044422,GO:0044424,GO:0044438,GO:0044439,GO:0044444,GO:0044446,GO:0044464,GO:0044743,GO:0045046,GO:0045184,GO:0045927,GO:0046395,GO:0046907,GO:0047485,GO:0048468,GO:0048513,GO:0048518,GO:0048519,GO:0048523,GO:0048638,GO:0048639,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0048870,GO:0050789,GO:0050793,GO:0050794,GO:0050877,GO:0050896,GO:0050905,GO:0051020,GO:0051094,GO:0051128,GO:0051129,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051259,GO:0051262,GO:0051641,GO:0051649,GO:0051674,GO:0055085,GO:0055114,GO:0060322,GO:0061024,GO:0065002,GO:0065003,GO:0065007,GO:0070013,GO:0070647,GO:0070727,GO:0071702,GO:0071704,GO:0071705,GO:0071806,GO:0071840,GO:0072329,GO:0072347,GO:0072594,GO:0072657,GO:0072662,GO:0072663,GO:0090150,GO:0098588,GO:0098805,GO:1901090,GO:1901091,GO:1901093,GO:1901094,GO:1901564,GO:1901575	-	ko:K13342,ko:K20915	ko04146,ko04621,map04146,map04621	-	-	-	ko00000,ko00001,ko04131	3.A.20.1	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_3266519_36	671143.DAMO_2346	5.728e-34	147.0	COG0484@1|root,COG3307@1|root,COG0484@2|Bacteria,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	DnaJ,Wzy_C
HKD1_k127_3266519_37	335543.Sfum_0084	9.554e-32	127.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MS96@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_3266519_16	1123487.KB892835_gene3611	1.436e-102	347.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2VH16@28216|Betaproteobacteria,2KVA7@206389|Rhodocyclales	206389|Rhodocyclales	L	Belongs to the DEAD box helicase family	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_3266519_53	243231.GSU3358	3.87e-07	56.0	2E6J8@1|root,3316B@2|Bacteria,1N7GY@1224|Proteobacteria,42V6W@68525|delta/epsilon subdivisions,2WRHG@28221|Deltaproteobacteria,43V7Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_15	1267533.KB906738_gene2031	3.453e-111	368.0	COG1398@1|root,COG1398@2|Bacteria,3Y3F9@57723|Acidobacteria,2JHWH@204432|Acidobacteriia	204432|Acidobacteriia	I	PFAM Fatty acid desaturase	-	-	1.14.19.1	ko:K00507	ko01040,ko01212,ko03320,ko04152,ko04212,map01040,map01212,map03320,map04152,map04212	-	R02222	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD1_k127_3266519_44	1347368.HG964409_gene7369	2.885e-24	103.0	COG0361@1|root,COG0361@2|Bacteria,1V9ZK@1239|Firmicutes,4HKF4@91061|Bacilli,1ZHWN@1386|Bacillus	91061|Bacilli	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	GO:0001871,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0009986,GO:0030246,GO:0030247,GO:0043021,GO:0043022,GO:0044424,GO:0044444,GO:0044464,GO:0044877,GO:2001065	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD1_k127_3266519_28	266117.Rxyl_2878	2.39e-44	166.0	COG0394@1|root,COG0394@2|Bacteria,2HEP3@201174|Actinobacteria,4CTHA@84995|Rubrobacteria	84995|Rubrobacteria	T	low molecular weight phosphotyrosine protein phosphatase	-	-	1.20.4.1	ko:K03741	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_3266519_5	357808.RoseRS_1917	6.225e-172	545.0	COG0798@1|root,COG0798@2|Bacteria,2G5ZH@200795|Chloroflexi,37708@32061|Chloroflexia	32061|Chloroflexia	P	Sodium Bile acid symporter family	-	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD1_k127_3266519_12	886293.Sinac_4607	1.264e-117	386.0	COG0500@1|root,COG2226@2|Bacteria,2IYB6@203682|Planctomycetes	203682|Planctomycetes	Q	Methylase involved in ubiquinone menaquinone	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD1_k127_3266519_8	204669.Acid345_4296	2.783e-130	436.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria,2JHX1@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_3266519_23	1185876.BN8_03503	6.59e-68	233.0	COG0698@1|root,COG0698@2|Bacteria,4NNSU@976|Bacteroidetes,47PQK@768503|Cytophagia	976|Bacteroidetes	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_3266519_13	868131.MSWAN_0806	5.451e-115	377.0	COG1741@1|root,arCOG02935@2157|Archaea,2XU8Z@28890|Euryarchaeota	28890|Euryarchaeota	S	Belongs to the Pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_3266519_40	63737.Npun_R2867	1.156e-29	124.0	2CIIF@1|root,315FB@2|Bacteria,1G6R8@1117|Cyanobacteria,1HT67@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_2	204669.Acid345_1748	3.085e-190	611.0	COG0492@1|root,COG0492@2|Bacteria,3Y3SH@57723|Acidobacteria,2JI51@204432|Acidobacteriia	204432|Acidobacteriia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_3266519_30	278963.ATWD01000001_gene3401	1.995e-43	162.0	2DMEF@1|root,32QYK@2|Bacteria,3Y516@57723|Acidobacteria,2JJEQ@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3266519_6	1173024.KI912148_gene3070	1.947e-161	525.0	COG0477@1|root,COG1359@1|root,COG0477@2|Bacteria,COG1359@2|Bacteria,1GD25@1117|Cyanobacteria,1JHWY@1189|Stigonemataceae	1117|Cyanobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_3266519_22	251229.Chro_0200	3.292e-76	263.0	COG4977@1|root,COG4977@2|Bacteria,1G48N@1117|Cyanobacteria,3VN0J@52604|Pleurocapsales	1117|Cyanobacteria	K	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD1_k127_3266519_14	1278073.MYSTI_02175	1.376e-113	376.0	COG4977@1|root,COG4977@2|Bacteria,1MUDK@1224|Proteobacteria,42U64@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI,HTH_18
HKD1_k127_3266519_52	234267.Acid_4703	2.994e-09	59.0	COG1228@1|root,COG1228@2|Bacteria,3Y32S@57723|Acidobacteria	57723|Acidobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_3266519_29	483219.LILAB_12015	3.253e-44	175.0	COG0526@1|root,COG0526@2|Bacteria,1NH1D@1224|Proteobacteria,42XJ2@68525|delta/epsilon subdivisions,2X5GC@28221|Deltaproteobacteria,2YUZX@29|Myxococcales	28221|Deltaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HKD1_k127_3266519_54	378806.STAUR_0972	1.123e-05	50.0	COG0526@1|root,COG0526@2|Bacteria,1QYGQ@1224|Proteobacteria,43CCZ@68525|delta/epsilon subdivisions,2X7NU@28221|Deltaproteobacteria,2Z3H8@29|Myxococcales	28221|Deltaproteobacteria	CO	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_7
HKD1_k127_3266519_21	204669.Acid345_2446	1.873e-92	318.0	COG4977@1|root,COG4977@2|Bacteria,3Y2HP@57723|Acidobacteria,2JIE6@204432|Acidobacteriia	204432|Acidobacteriia	K	PFAM ThiJ PfpI	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD1_k127_3266519_1	234267.Acid_3143	1.655e-234	743.0	COG3408@1|root,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	glgX	-	-	-	-	-	-	-	-	-	-	-	GDE_C,GDE_N
HKD1_k127_3266519_4	251221.35211731	1.1e-174	556.0	COG1063@1|root,COG1063@2|Bacteria	2|Bacteria	E	alcohol dehydrogenase	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,Glu_dehyd_C
HKD1_k127_3266519_25	671143.DAMO_1116	3.822e-56	210.0	COG0836@1|root,COG0836@2|Bacteria,2NP3C@2323|unclassified Bacteria	2|Bacteria	M	Mannose-6-phosphate isomerase	manC	-	2.7.7.13,5.3.1.8	ko:K00971,ko:K16011	ko00051,ko00520,ko01100,ko01110,ko01130,ko02025,map00051,map00520,map01100,map01110,map01130,map02025	M00114,M00361,M00362	R00885,R01819	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	MannoseP_isomer,NTP_transferase
HKD1_k127_3266519_0	671143.DAMO_0621	0.0	1446.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K22110	-	-	-	-	ko00000,ko02000	1.B.35.1,1.B.35.2	-	-	Glyco_hydro_63
HKD1_k127_3282997_4	1396141.BATP01000002_gene4798	9.54e-54	205.0	COG4191@1|root,COG4191@2|Bacteria,46ZJR@74201|Verrucomicrobia,2IV4D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD1_k127_3282997_5	1248916.ANFY01000010_gene419	4.201e-53	190.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria,2UCCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
HKD1_k127_3282997_7	913865.DOT_4712	1.805e-28	117.0	2E9H4@1|root,333Q5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3282997_8	332101.JIBU02000013_gene1350	1.268e-21	109.0	2BCB5@1|root,325WF@2|Bacteria,1URWB@1239|Firmicutes,24XYD@186801|Clostridia,36QUA@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3282997_2	1007103.AFHW01000032_gene2246	2.782e-92	311.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD1_k127_3282997_0	700598.Niako_5817	8.499e-169	544.0	COG0076@1|root,COG0076@2|Bacteria,4NFUP@976|Bacteroidetes,1IVP1@117747|Sphingobacteriia	976|Bacteroidetes	E	COGs COG0076 Glutamate decarboxylase and related PLP-dependent protein	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD1_k127_3282997_1	886293.Sinac_4341	6.054e-125	407.0	COG1171@1|root,COG1171@2|Bacteria,2IYNJ@203682|Planctomycetes	203682|Planctomycetes	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3282997_3	1120956.JHZK01000016_gene2176	1.898e-56	201.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,1JP4X@119043|Rhodobiaceae	28211|Alphaproteobacteria	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD1_k127_3282997_6	1038859.AXAU01000018_gene6650	1.984e-30	121.0	COG0640@1|root,COG0640@2|Bacteria,1N8QA@1224|Proteobacteria,2UC02@28211|Alphaproteobacteria,3JZ6B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	ybzH	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_332788_15	204669.Acid345_0558	3.811e-16	90.0	COG2834@1|root,COG2834@2|Bacteria,3Y4A1@57723|Acidobacteria,2JJ5F@204432|Acidobacteriia	204432|Acidobacteriia	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4292
HKD1_k127_332788_3	1123242.JH636434_gene5626	1.161e-87	299.0	COG4886@1|root,COG5426@1|root,COG4886@2|Bacteria,COG5426@2|Bacteria	2|Bacteria	D	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	DUF285,Flg_new,LRR_5,LRR_6
HKD1_k127_332788_1	234267.Acid_3616	5.239e-168	537.0	COG0436@1|root,COG0436@2|Bacteria,3Y2TF@57723|Acidobacteria	57723|Acidobacteria	E	PFAM aminotransferase, class I	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_332788_17	867845.KI911784_gene2035	2.783e-07	61.0	COG0457@1|root,COG0457@2|Bacteria,2GAB4@200795|Chloroflexi,374UY@32061|Chloroflexia	32061|Chloroflexia	S	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2
HKD1_k127_332788_13	204669.Acid345_4342	1.285e-32	137.0	COG3748@1|root,COG3748@2|Bacteria	2|Bacteria	S	Urate oxidase N-terminal	MA20_17625	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HKD1_k127_332788_6	215803.DB30_2740	7.14e-64	225.0	COG0605@1|root,COG0605@2|Bacteria,1R4Z3@1224|Proteobacteria,42QV7@68525|delta/epsilon subdivisions,2WMPC@28221|Deltaproteobacteria,2YVDJ@29|Myxococcales	28221|Deltaproteobacteria	C	Iron/manganese superoxide dismutases, C-terminal domain	sodA	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_332788_9	1173022.Cri9333_2083	8.141e-47	181.0	COG0508@1|root,COG0508@2|Bacteria,1G0YZ@1117|Cyanobacteria,1H75Z@1150|Oscillatoriales	1117|Cyanobacteria	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_332788_12	1131269.AQVV01000001_gene1432	8.808e-35	141.0	COG1573@1|root,COG1573@2|Bacteria	2|Bacteria	L	deaminated base DNA N-glycosylase activity	ung2	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_332788_10	215803.DB30_0168	4.412e-43	171.0	COG0404@1|root,COG0404@2|Bacteria,1QX3Y@1224|Proteobacteria,43BWD@68525|delta/epsilon subdivisions,2X775@28221|Deltaproteobacteria,2YVVR@29|Myxococcales	28221|Deltaproteobacteria	E	Glycine cleavage T-protein C-terminal barrel domain	-	-	2.1.2.10	ko:K00605,ko:K06980	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	GCV_T,GCV_T_C
HKD1_k127_332788_7	1227739.Hsw_3983	5.552e-62	222.0	2E4YY@1|root,32ZSQ@2|Bacteria,4P5XB@976|Bacteroidetes,47W1A@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_332788_4	118168.MC7420_778	2.149e-76	261.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,1H9WZ@1150|Oscillatoriales	1117|Cyanobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_332788_16	243233.MCA1292	1.837e-13	75.0	2DD9Q@1|root,2ZH70@2|Bacteria,1P8P5@1224|Proteobacteria,1SWFT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_332788_2	378806.STAUR_0362	3.737e-141	460.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,42QCN@68525|delta/epsilon subdivisions,2WIYT@28221|Deltaproteobacteria,2YV4K@29|Myxococcales	28221|Deltaproteobacteria	P	Chromate transporter	chrA	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_332788_5	204669.Acid345_3369	9.661e-74	259.0	COG0515@1|root,COG0515@2|Bacteria	204669.Acid345_3369|-	KLT	protein kinase activity	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD1_k127_332788_11	1121285.AUFK01000018_gene667	2.441e-38	149.0	COG1764@1|root,COG1764@2|Bacteria,4PK2I@976|Bacteroidetes,1I3KT@117743|Flavobacteriia,3ZUDM@59732|Chryseobacterium	976|Bacteroidetes	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_332788_14	1996.JOFO01000012_gene1553	1.884e-24	109.0	COG0723@1|root,COG0723@2|Bacteria,2I02M@201174|Actinobacteria	201174|Actinobacteria	C	Rieske [2Fe-2S] domain	-	-	-	-	-	-	-	-	-	-	-	-	Rieske
HKD1_k127_332788_0	1382356.JQMP01000003_gene1584	0.0	1025.0	COG0045@1|root,COG1042@1|root,COG0045@2|Bacteria,COG1042@2|Bacteria,2G5QB@200795|Chloroflexi,27XKK@189775|Thermomicrobia	189775|Thermomicrobia	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD1_k127_332788_8	237368.SCABRO_03671	4.763e-50	187.0	29Z27@1|root,30KZN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3330122_6	497964.CfE428DRAFT_3301	8.246e-48	172.0	COG0422@1|root,COG0422@2|Bacteria,46S5R@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD1_k127_3330122_0	204669.Acid345_1623	7.617e-195	614.0	COG0205@1|root,COG0205@2|Bacteria,3Y4A9@57723|Acidobacteria,2JKQ8@204432|Acidobacteriia	204432|Acidobacteriia	G	Phosphofructokinase	-	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_3330122_9	1123228.AUIH01000061_gene3507	1.659e-20	93.0	COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,1SECR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_3330122_4	1278309.KB907102_gene197	3.387e-65	232.0	COG1733@1|root,COG1733@2|Bacteria,1NEKW@1224|Proteobacteria,1RYP5@1236|Gammaproteobacteria,1XRI6@135619|Oceanospirillales	135619|Oceanospirillales	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_3330122_3	221288.JH992900_gene387	6.761e-82	278.0	COG2258@1|root,COG2258@2|Bacteria,1G4BR@1117|Cyanobacteria,1JKN0@1189|Stigonemataceae	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,MOSC
HKD1_k127_3330122_1	330214.NIDE0254	4.01e-121	402.0	COG0006@1|root,COG0006@2|Bacteria	2|Bacteria	E	proline dipeptidase activity	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD1_k127_3330122_2	204669.Acid345_4117	1.632e-117	414.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_3330122_5	1183438.GKIL_3396	2.183e-56	202.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_3330122_7	1173026.Glo7428_2073	5.012e-44	175.0	COG2931@1|root,COG2931@2|Bacteria,1GB2M@1117|Cyanobacteria	1117|Cyanobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3330122_10	1173020.Cha6605_0235	2.521e-10	63.0	COG2337@1|root,COG2337@2|Bacteria,1G7JA@1117|Cyanobacteria	1117|Cyanobacteria	T	PFAM PemK-like protein	-	-	-	ko:K07171	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PemK_toxin
HKD1_k127_3424823_19	1210908.HSB1_42370	2.065e-64	235.0	COG0436@1|root,arCOG01130@2157|Archaea,2XSVT@28890|Euryarchaeota,23SDZ@183963|Halobacteria	183963|Halobacteria	E	COG0436 Aspartate tyrosine aromatic aminotransferase	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3424823_11	204669.Acid345_2087	1.682e-109	361.0	COG2171@1|root,COG2171@2|Bacteria,3Y2Z3@57723|Acidobacteria,2JIDV@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the transferase hexapeptide repeat family	-	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep_2,THDPS_N_2
HKD1_k127_3424823_12	204669.Acid345_2493	5.398e-95	320.0	COG0329@1|root,COG0329@2|Bacteria,3Y3V8@57723|Acidobacteria,2JICI@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_3424823_22	158190.SpiGrapes_0769	5.119e-55	201.0	COG0289@1|root,COG0289@2|Bacteria,2J647@203691|Spirochaetes	203691|Spirochaetes	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD1_k127_3424823_13	1382359.JIAL01000001_gene2279	4.661e-90	307.0	COG0624@1|root,COG0624@2|Bacteria,3Y2K0@57723|Acidobacteria,2JIEY@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM peptidase	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3424823_9	204669.Acid345_2491	8.901e-115	386.0	COG0527@1|root,COG0527@2|Bacteria,3Y34W@57723|Acidobacteria,2JHV2@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT
HKD1_k127_3424823_26	880073.Calab_3784	7.07e-26	114.0	COG1986@1|root,COG1986@2|Bacteria,2NS1I@2323|unclassified Bacteria	2|Bacteria	F	Protein of unknown function DUF84	yjjX	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017111,GO:0017144,GO:0034641,GO:0042723,GO:0044237,GO:0044281,GO:0046483,GO:0071704,GO:0072527,GO:1901360,GO:1901564	-	-	-	-	-	-	-	-	-	iECO111_1330.ECO111_5255	NTPase_I-T
HKD1_k127_3424823_5	1379698.RBG1_1C00001G0513	2.248e-147	477.0	COG0119@1|root,COG0119@2|Bacteria,2NNNZ@2323|unclassified Bacteria	2|Bacteria	E	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)	leuA3	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_3424823_28	880073.Calab_3013	1.075e-11	76.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388,GGDEF,Response_reg
HKD1_k127_3424823_33	742743.HMPREF9453_00655	4.407e-05	55.0	COG0810@1|root,COG0810@2|Bacteria,1VDCH@1239|Firmicutes,4H54A@909932|Negativicutes	909932|Negativicutes	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_3424823_32	330214.NIDE1600	1.478e-06	60.0	COG3209@1|root,COG3209@2|Bacteria	2|Bacteria	M	self proteolysis	-	-	-	-	-	-	-	-	-	-	-	-	Big_3,PT-HINT,RHS_repeat
HKD1_k127_3424823_16	204669.Acid345_4495	4.757e-79	285.0	COG2027@1|root,COG2027@2|Bacteria,3Y3WF@57723|Acidobacteria,2JIBN@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Peptidase S13, D-Ala-D-Ala carboxypeptidase C	-	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD1_k127_3424823_25	742743.HMPREF9453_00621	4.829e-34	144.0	COG0859@1|root,COG0859@2|Bacteria,1TRN2@1239|Firmicutes,4H25K@909932|Negativicutes	909932|Negativicutes	M	lipopolysaccharide heptosyltransferase	rfaF	-	-	ko:K02841,ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD1_k127_3424823_2	204669.Acid345_1151	5.457e-202	650.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3NT@57723|Acidobacteria,2JIBK@204432|Acidobacteriia	204432|Acidobacteriia	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD1_k127_3424823_17	1210884.HG799466_gene13018	1.11e-75	265.0	COG1230@1|root,COG1230@2|Bacteria,2J098@203682|Planctomycetes	203682|Planctomycetes	P	Cation efflux family	-	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD1_k127_3424823_14	316067.Geob_0833	2.46e-87	304.0	COG3875@1|root,COG3875@2|Bacteria,1R79Y@1224|Proteobacteria,42PGD@68525|delta/epsilon subdivisions,2WMB6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_3424823_21	870187.Thini_1169	3.725e-59	216.0	COG0589@1|root,COG0589@2|Bacteria,1N5Z8@1224|Proteobacteria	1224|Proteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3424823_3	861299.J421_1661	1.1e-180	578.0	COG0534@1|root,COG0534@2|Bacteria,1ZUGI@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_3424823_23	215803.DB30_7594	1.308e-47	183.0	COG1716@1|root,COG2199@1|root,COG1716@2|Bacteria,COG3706@2|Bacteria,1MZV7@1224|Proteobacteria,4302C@68525|delta/epsilon subdivisions,2WVBW@28221|Deltaproteobacteria,2YUSZ@29|Myxococcales	28221|Deltaproteobacteria	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,GGDEF,Yop-YscD_cpl
HKD1_k127_3424823_18	1089548.KI783301_gene2821	1.476e-68	239.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,4H9PW@91061|Bacilli,3WFAX@539002|Bacillales incertae sedis	91061|Bacilli	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	GO:0003674,GO:0003824,GO:0003933,GO:0003935,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0008686,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016787,GO:0016810,GO:0016814,GO:0016829,GO:0016830,GO:0017144,GO:0018130,GO:0019238,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iSB619.SA_RS08945	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_3424823_27	234267.Acid_7377	5.772e-16	92.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria	57723|Acidobacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3424823_30	877455.Metbo_1438	4.417e-07	61.0	COG0457@1|root,arCOG03038@2157|Archaea	2157|Archaea	KLT	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_3424823_34	215803.DB30_8915	0.0003127	52.0	COG0457@1|root,COG0457@2|Bacteria,1Q2K2@1224|Proteobacteria,433SN@68525|delta/epsilon subdivisions,2WXMA@28221|Deltaproteobacteria,2YW10@29|Myxococcales	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_3424823_10	1121920.AUAU01000012_gene2631	1.68e-113	404.0	COG1629@1|root,COG4771@2|Bacteria,3Y3ZU@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_3424823_15	1121938.AUDY01000009_gene2075	3.004e-84	296.0	COG1078@1|root,COG1078@2|Bacteria,1TPVB@1239|Firmicutes,4HAX8@91061|Bacilli,3ND9T@45667|Halobacillus	91061|Bacilli	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	ywfO	GO:0003674,GO:0003824,GO:0006139,GO:0006163,GO:0006195,GO:0006203,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008832,GO:0009056,GO:0009058,GO:0009117,GO:0009141,GO:0009143,GO:0009144,GO:0009146,GO:0009151,GO:0009155,GO:0009166,GO:0009200,GO:0009204,GO:0009215,GO:0009217,GO:0009262,GO:0009264,GO:0009394,GO:0009987,GO:0016787,GO:0016788,GO:0016793,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0019692,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0042578,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046070,GO:0046386,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:0072521,GO:0072523,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901564,GO:1901565,GO:1901575,GO:1901576	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_3424823_29	1144275.COCOR_04379	2.22e-07	62.0	COG0810@1|root,COG4206@1|root,COG0810@2|Bacteria,COG4206@2|Bacteria,1QX76@1224|Proteobacteria,42V4D@68525|delta/epsilon subdivisions,2WRH8@28221|Deltaproteobacteria,2YU3M@29|Myxococcales	28221|Deltaproteobacteria	HM	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	Plug,TonB_C,TonB_dep_Rec
HKD1_k127_3424823_6	861299.J421_3334	1.912e-143	466.0	COG1228@1|root,COG1228@2|Bacteria,1ZTI7@142182|Gemmatimonadetes	861299.J421_3334|-	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3424823_1	861299.J421_3333	1.064e-215	681.0	COG1228@1|root,COG1228@2|Bacteria,1ZTC8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_3424823_8	525904.Tter_2338	3.682e-122	405.0	COG2239@1|root,COG2239@2|Bacteria,2NP79@2323|unclassified Bacteria	2|Bacteria	P	MgtE intracellular N domain	mgtE	-	-	-	-	-	-	-	-	-	-	-	CBS,MgtE_N,PRC
HKD1_k127_3424823_7	485913.Krac_6826	1.176e-132	436.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS07840	Nramp
HKD1_k127_3424823_20	215803.DB30_3013	8.911e-62	230.0	COG0664@1|root,COG3264@1|root,COG0664@2|Bacteria,COG3264@2|Bacteria,1QX62@1224|Proteobacteria,42S57@68525|delta/epsilon subdivisions,2WNY0@28221|Deltaproteobacteria,2YVPP@29|Myxococcales	28221|Deltaproteobacteria	MT	Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD1_k127_3424823_24	240015.ACP_2406	2.457e-40	154.0	COG0071@1|root,COG0071@2|Bacteria,3Y4TM@57723|Acidobacteria,2JJFI@204432|Acidobacteriia	204432|Acidobacteriia	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_3424823_0	1121405.dsmv_2717	0.0	1102.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,42M9S@68525|delta/epsilon subdivisions,2WJSZ@28221|Deltaproteobacteria,2MHW3@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_3424823_4	429009.Adeg_1948	7.356e-155	517.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,42FKB@68295|Thermoanaerobacterales	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD1_k127_3424823_31	553219.CAMSH0001_1347	6.522e-07	62.0	COG0745@1|root,COG0745@2|Bacteria,1RDNP@1224|Proteobacteria,42RF8@68525|delta/epsilon subdivisions,2YP7F@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	KT	Chemotaxis protein cheY	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_3432393_12	272134.KB731324_gene2230	4.026e-63	220.0	COG2897@1|root,COG2897@2|Bacteria	2|Bacteria	P	thiosulfate sulfurtransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_3432393_9	1382304.JNIL01000001_gene1358	1.62e-108	357.0	COG0338@1|root,COG0338@2|Bacteria,1TRDX@1239|Firmicutes,4HDFS@91061|Bacilli	91061|Bacilli	L	Site-specific DNA-methyltransferase (Adenine-specific)	dpnM	-	2.1.1.72	ko:K06223	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko02048,ko03032,ko03400	-	-	-	MethyltransfD12
HKD1_k127_3432393_23	1385517.N800_12010	0.000251	53.0	2AQ2A@1|root,31F7E@2|Bacteria,1QCMG@1224|Proteobacteria,1T8CS@1236|Gammaproteobacteria,1XAFU@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3432393_10	661478.OP10G_2718	3.836e-86	295.0	COG0412@1|root,COG0412@2|Bacteria	2|Bacteria	Q	carboxymethylenebutenolidase activity	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	AXE1,DLH
HKD1_k127_3432393_15	102125.Xen7305DRAFT_00051540	1.709e-35	148.0	COG0491@1|root,COG0491@2|Bacteria,1GNN3@1117|Cyanobacteria,3VNCV@52604|Pleurocapsales	1117|Cyanobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_3432393_13	1090320.KB900605_gene3601	5.888e-60	214.0	COG0586@1|root,COG0586@2|Bacteria,1Q68Z@1224|Proteobacteria,2UA40@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_3432393_7	1128421.JAGA01000003_gene3195	2.02e-114	382.0	COG0477@1|root,COG2814@2|Bacteria,2NQP3@2323|unclassified Bacteria	2|Bacteria	EGP	Transmembrane secretion effector	entS	-	-	ko:K08225	-	-	-	-	ko00000,ko02000	2.A.1.38	-	-	MFS_1,MFS_3
HKD1_k127_3432393_2	78245.Xaut_4350	7.354e-240	752.0	COG1620@1|root,COG1620@2|Bacteria,1MV13@1224|Proteobacteria,2TQY1@28211|Alphaproteobacteria,3F0NG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	TIGRFAM L-lactate transport	-	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HKD1_k127_3432393_0	1379270.AUXF01000003_gene3587	0.0	1369.0	COG4447@1|root,COG4447@2|Bacteria,1ZSRM@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_3432393_4	378806.STAUR_0571	3.584e-190	604.0	COG2304@1|root,COG2304@2|Bacteria,1R8EZ@1224|Proteobacteria,433AE@68525|delta/epsilon subdivisions,2WYFQ@28221|Deltaproteobacteria,2YY3M@29|Myxococcales	28221|Deltaproteobacteria	S	IgA Peptidase M64	-	-	-	-	-	-	-	-	-	-	-	-	M64_N,Peptidase_M64
HKD1_k127_3432393_1	204669.Acid345_0490	5.163e-288	901.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3X0@57723|Acidobacteria,2JIZ1@204432|Acidobacteriia	204432|Acidobacteriia	EU	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_3432393_22	1123278.KB893422_gene1616	2.658e-05	55.0	COG4319@1|root,COG4319@2|Bacteria,4NSA0@976|Bacteroidetes,47RMW@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_3432393_11	306281.AJLK01000102_gene3405	1.529e-76	260.0	COG2258@1|root,COG2258@2|Bacteria,1GE7I@1117|Cyanobacteria	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3432393_5	1385519.N801_15180	9.944e-167	539.0	COG2232@1|root,COG2232@2|Bacteria,2HPI0@201174|Actinobacteria,4FK2A@85021|Intrasporangiaceae	201174|Actinobacteria	S	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	ATP-grasp_3
HKD1_k127_3432393_21	929556.Solca_3195	7.995e-18	88.0	COG3040@1|root,COG3040@2|Bacteria	2|Bacteria	M	lipid binding	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD1_k127_3432393_8	204669.Acid345_1052	3.32e-112	386.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_3432393_19	682795.AciX8_3255	2.835e-19	103.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria,2JIZ4@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD1_k127_3432393_20	1121904.ARBP01000067_gene2212	2.989e-18	89.0	COG0745@1|root,COG4585@1|root,COG0745@2|Bacteria,COG4585@2|Bacteria,4PI9C@976|Bacteroidetes,47QA0@768503|Cytophagia	976|Bacteroidetes	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,Response_reg
HKD1_k127_3432393_3	234267.Acid_7772	1.441e-191	605.0	2BXG3@1|root,2Z82R@2|Bacteria,3Y3HC@57723|Acidobacteria	57723|Acidobacteria	S	tagaturonate epimerase	-	-	5.1.2.7	ko:K21619	ko00040,ko01100,map00040,map01100	-	R11624	-	ko00000,ko00001,ko01000	-	-	-	UxaE
HKD1_k127_3432393_17	204669.Acid345_4349	2.641e-24	110.0	COG2010@1|root,COG2010@2|Bacteria,3Y4X7@57723|Acidobacteria,2JJFH@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD1_k127_3432393_16	1144319.PMI16_00807	1.792e-32	130.0	COG1622@1|root,COG1622@2|Bacteria,1NEC9@1224|Proteobacteria,2VWA0@28216|Betaproteobacteria,477JR@75682|Oxalobacteraceae	28216|Betaproteobacteria	C	Cupredoxin-like domain	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	Cupredoxin_1
HKD1_k127_3432393_6	1144319.PMI16_00806	8.372e-129	420.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2VJNP@28216|Betaproteobacteria,475EI@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_3432393_14	204669.Acid345_2486	4.89e-52	192.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria,2JHY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_3433957_5	204669.Acid345_3921	2.615e-68	238.0	COG0146@1|root,COG0146@2|Bacteria,3Y6W2@57723|Acidobacteria,2JKCE@204432|Acidobacteriia	204432|Acidobacteriia	EQ	Hydantoinase B/oxoprolinase	-	-	3.5.2.14	ko:K01474	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydantoinase_B
HKD1_k127_3433957_2	204669.Acid345_2039	6.764e-180	587.0	COG0145@1|root,COG0145@2|Bacteria,3Y6D5@57723|Acidobacteria,2JKXC@204432|Acidobacteriia	204432|Acidobacteriia	EQ	Hydantoinase/oxoprolinase	-	-	3.5.2.14	ko:K01473	ko00330,ko01100,map00330,map01100	-	R03187	RC00632	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A
HKD1_k127_3433957_1	1267533.KB906733_gene3552	6.615e-190	625.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	manA5	-	3.2.1.51,3.2.1.78	ko:K01206,ko:K01218	ko00051,ko00511,ko02024,map00051,map00511,map02024	-	R01332	RC00467	ko00000,ko00001,ko01000,ko04147	-	GH26,GH29	-	Alpha_L_fucos,Cytochrome_P460,Glyco_hydro_26,PA14,RsgI_N
HKD1_k127_3433957_11	204669.Acid345_4448	8.753e-22	107.0	COG1595@1|root,COG1595@2|Bacteria,3Y7TB@57723|Acidobacteria,2JMZD@204432|Acidobacteriia	204432|Acidobacteriia	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	-
HKD1_k127_3433957_6	1123258.AQXZ01000018_gene1121	7.271e-63	225.0	COG1404@1|root,COG1404@2|Bacteria,2IRXR@201174|Actinobacteria,4FZ50@85025|Nocardiaceae	201174|Actinobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_3433957_12	1144275.COCOR_05401	2.324e-10	70.0	COG2199@1|root,COG2203@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,42Q7A@68525|delta/epsilon subdivisions,2WM81@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF
HKD1_k127_3433957_10	1370125.AUWT01000032_gene1637	1.364e-41	163.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	tlpA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_3433957_0	710685.MycrhN_1487	3.023e-209	674.0	COG1132@1|root,COG1132@2|Bacteria,2GUVF@201174|Actinobacteria,236TF@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_3433957_13	99598.Cal7507_5682	1.886e-08	65.0	2EJW0@1|root,33DKR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3433957_3	1297742.A176_01568	1.931e-102	344.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,43C12@68525|delta/epsilon subdivisions,2WXMX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_3433957_4	768710.DesyoDRAFT_2386	1.598e-68	258.0	COG5373@1|root,COG5373@2|Bacteria,1UUGX@1239|Firmicutes,24EBQ@186801|Clostridia,26413@186807|Peptococcaceae	186801|Clostridia	S	Predicted membrane protein (DUF2339)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2339
HKD1_k127_3433957_8	1123508.JH636449_gene7410	1.579e-50	199.0	COG5373@1|root,COG5373@2|Bacteria	2|Bacteria	KLT	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF3999,LptC,NLPC_P60,SH3_3
HKD1_k127_3433957_9	395961.Cyan7425_4762	1.593e-46	176.0	2DC9X@1|root,2ZDDA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3433957_7	861299.J421_4348	1.006e-61	222.0	2EEQM@1|root,338IB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3574582_0	1121406.JAEX01000002_gene1126	1.589e-108	362.0	COG0500@1|root,COG1215@1|root,COG1215@2|Bacteria,COG2226@2|Bacteria,1QU2F@1224|Proteobacteria,42P7H@68525|delta/epsilon subdivisions,2WKJA@28221|Deltaproteobacteria,2M9BR@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HKD1_k127_3574582_5	1124780.ANNU01000062_gene578	4.842e-17	90.0	COG0500@1|root,COG2226@2|Bacteria,4NJZ2@976|Bacteroidetes	976|Bacteroidetes	Q	Ubiquinone biosynthesis methyltransferase UbiE	-	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_3574582_1	936136.ARRT01000006_gene2232	1.008e-86	294.0	COG0500@1|root,COG2226@2|Bacteria,1RFDN@1224|Proteobacteria,2VDU0@28211|Alphaproteobacteria,4BISY@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3574582_2	936136.ARRT01000006_gene2231	1.404e-59	215.0	COG2520@1|root,COG2520@2|Bacteria,1PJK4@1224|Proteobacteria,2VB8G@28211|Alphaproteobacteria,4BHI1@82115|Rhizobiaceae	28211|Alphaproteobacteria	J	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD1_k127_3574582_4	1034943.BN1094_03368	1.117e-46	190.0	2E8FH@1|root,332TU@2|Bacteria,1NEHW@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3574582_3	504472.Slin_3706	1.382e-50	195.0	COG0455@1|root,COG0455@2|Bacteria	2|Bacteria	D	bacterial-type flagellum organization	-	-	-	ko:K02282,ko:K04562	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,CbiA,GSCFA
HKD1_k127_3685313_3	234267.Acid_5495	8.645e-94	314.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	1.13.12.3	ko:K00466	ko00380,map00380	-	R00679	RC00213	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_3685313_5	632335.Calkr_1515	2.927e-51	195.0	COG5263@1|root,COG5263@2|Bacteria,1V2GT@1239|Firmicutes,24EI0@186801|Clostridia,42IJP@68295|Thermoanaerobacterales	186801|Clostridia	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,WG_beta_rep
HKD1_k127_3685313_1	234267.Acid_6457	1.147e-117	393.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_3685313_7	383372.Rcas_3002	7.631e-06	54.0	COG0745@1|root,COG2203@1|root,COG4191@1|root,COG0745@2|Bacteria,COG2203@2|Bacteria,COG4191@2|Bacteria,2G7Y4@200795|Chloroflexi,374VX@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase A domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_9,Response_reg
HKD1_k127_3685313_2	1173028.ANKO01000170_gene3367	7.569e-101	333.0	COG1741@1|root,COG1741@2|Bacteria,1G0UH@1117|Cyanobacteria,1H7AV@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HKD1_k127_3685313_6	240015.ACP_3460	2.306e-13	78.0	COG1763@1|root,COG1763@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	-	-	-	ko:K03753,ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_3685313_4	670292.JH26_23690	1.182e-63	221.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	COG1956 GAF domain-containing protein	msrC	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
HKD1_k127_3685313_0	215803.DB30_8023	4.837e-181	574.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2X7DH@28221|Deltaproteobacteria,2YUKN@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HKD1_k127_3771014_19	1487953.JMKF01000015_gene6227	3.474e-61	218.0	COG1670@1|root,COG1670@2|Bacteria,1G6XM@1117|Cyanobacteria,1HCHH@1150|Oscillatoriales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_3771014_29	1340493.JNIF01000003_gene1493	9.395e-21	98.0	2E32R@1|root,32Y2Y@2|Bacteria,3Y5RV@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3771014_35	113395.AXAI01000002_gene5247	1.639e-05	54.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,Trans_reg_C
HKD1_k127_3771014_31	1283287.KB822579_gene1939	3.663e-16	81.0	2E3SC@1|root,32YPX@2|Bacteria,2GQRK@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF1059)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_3771014_22	228410.NE0771	1.962e-50	191.0	COG4235@1|root,COG4235@2|Bacteria,1MY4J@1224|Proteobacteria,2VQ05@28216|Betaproteobacteria,3722S@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Tetratricopeptide repeat	cycH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_16,TPR_2
HKD1_k127_3771014_23	1163617.SCD_n02733	3.056e-44	166.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2VU7C@28216|Betaproteobacteria	28216|Betaproteobacteria	P	subunit of a heme lyase	ccmH	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HKD1_k127_3771014_16	452638.Pnec_1377	1.174e-69	239.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2VR8D@28216|Betaproteobacteria,1K777@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	dsbE	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_3771014_1	1266925.JHVX01000001_gene2488	1.589e-299	932.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2VHUE@28216|Betaproteobacteria,3725U@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Cytochrome c-type biogenesis protein CcmF	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD1_k127_3771014_20	261292.Nit79A3_1271	2.735e-57	203.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2VRKZ@28216|Betaproteobacteria,3731F@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD1_k127_3771014_32	153948.NAL212_1560	1.874e-12	71.0	COG3114@1|root,COG3114@2|Bacteria,1NGBM@1224|Proteobacteria,2VY1Y@28216|Betaproteobacteria,373N5@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	-	-	-	ko:K02196	ko02010,map02010	-	-	-	ko00000,ko00001,ko02000	3.A.1.107	-	-	CcmD
HKD1_k127_3771014_9	1266925.JHVX01000001_gene2490	6.811e-105	345.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2VHF8@28216|Betaproteobacteria,3729C@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD1_k127_3771014_11	1131553.JIBI01000009_gene1228	2.216e-81	278.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2VNPU@28216|Betaproteobacteria,371Q1@32003|Nitrosomonadales	28216|Betaproteobacteria	U	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD1_k127_3771014_17	1131553.JIBI01000009_gene1227	2.356e-67	234.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2VMGA@28216|Betaproteobacteria,372UK@32003|Nitrosomonadales	28216|Betaproteobacteria	P	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HKD1_k127_3771014_34	330214.NIDE0059	6.939e-11	69.0	COG0586@1|root,COG0607@1|root,COG0586@2|Bacteria,COG0607@2|Bacteria,3J1E4@40117|Nitrospirae	40117|Nitrospirae	P	Evidence 4 Homologs of previously reported genes of	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	Rhodanese,SNARE_assoc
HKD1_k127_3771014_12	1267533.KB906737_gene1940	1.339e-78	280.0	COG3488@1|root,COG3488@2|Bacteria,3Y3DB@57723|Acidobacteria,2JK0S@204432|Acidobacteriia	204432|Acidobacteriia	C	Di-haem oxidoreductase, putative peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	DHOR
HKD1_k127_3771014_4	765420.OSCT_0360	1.866e-157	514.0	COG1429@1|root,COG1429@2|Bacteria,2GAMU@200795|Chloroflexi,376SM@32061|Chloroflexia	32061|Chloroflexia	H	TIGRFAM magnesium chelatase, H subunit	-	-	6.6.1.1	ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel,DUF3479
HKD1_k127_3771014_5	498761.HM1_0682	4.233e-153	511.0	COG1429@1|root,COG1429@2|Bacteria,1TRGA@1239|Firmicutes,24BG0@186801|Clostridia	186801|Clostridia	H	PFAM CobN Magnesium Chelatase	bchH	-	6.6.1.1,6.6.1.2	ko:K02230,ko:K03403	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877,R05227	RC01012,RC02000	ko00000,ko00001,ko01000	-	-	-	CobN-Mg_chel
HKD1_k127_3771014_33	234267.Acid_4806	2.146e-12	70.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	DUF836,Thioredoxin,Thioredoxin_3
HKD1_k127_3771014_15	234267.Acid_4388	8.992e-74	254.0	COG0723@1|root,COG0723@2|Bacteria	2|Bacteria	C	oxidoreductase activity, acting on diphenols and related substances as donors	-	-	1.10.9.1	ko:K02636,ko:K03886	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00151,M00162	R03817,R08409	RC01002	ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	Rieske
HKD1_k127_3771014_7	234267.Acid_4387	3.301e-145	465.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD1_k127_3771014_8	234267.Acid_4386	1.144e-127	419.0	COG1290@1|root,COG1290@2|Bacteria	2|Bacteria	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_B_C
HKD1_k127_3771014_0	234267.Acid_4385	4.781e-308	983.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,PA14
HKD1_k127_3771014_21	234267.Acid_4384	3.073e-52	196.0	COG3794@1|root,COG3794@2|Bacteria,3Y4A0@57723|Acidobacteria	57723|Acidobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_3771014_24	234267.Acid_4383	5.112e-42	168.0	COG1612@1|root,COG1612@2|Bacteria	2|Bacteria	O	heme a metabolic process	ctaA	-	-	ko:K02259,ko:K03110	ko00190,ko00860,ko01100,ko01110,ko02020,ko02024,ko03060,ko03070,ko04714,map00190,map00860,map01100,map01110,map02020,map02024,map03060,map03070,map04714	M00154,M00335	R07412	RC00769	ko00000,ko00001,ko00002,ko02044,ko03029	3.A.5.1,3.A.5.2,3.A.5.7,3.D.4.4	-	-	COX15-CtaA
HKD1_k127_3771014_10	1267535.KB906767_gene1277	1.023e-88	302.0	COG0109@1|root,COG0109@2|Bacteria,3Y3VI@57723|Acidobacteria,2JIRB@204432|Acidobacteriia	204432|Acidobacteriia	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD1_k127_3771014_13	234267.Acid_5589	5.83e-76	263.0	COG1622@1|root,COG1622@2|Bacteria,3Y4UA@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase subunit II	-	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2
HKD1_k127_3771014_2	1123248.KB893319_gene3966	1.54e-196	630.0	COG0843@1|root,COG0843@2|Bacteria,4NEH8@976|Bacteroidetes,1IPZE@117747|Sphingobacteriia	976|Bacteroidetes	C	Belongs to the heme-copper respiratory oxidase family	coxN	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD1_k127_3771014_26	234267.Acid_5591	8.402e-31	130.0	COG1845@1|root,COG1845@2|Bacteria,3Y2KJ@57723|Acidobacteria	57723|Acidobacteria	C	PFAM cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_3771014_25	1267533.KB906738_gene2144	1.334e-33	136.0	COG1845@1|root,COG1845@2|Bacteria,3Y7YE@57723|Acidobacteria,2JN0U@204432|Acidobacteriia	204432|Acidobacteriia	C	cytochrome c oxidase, subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	-
HKD1_k127_3771014_18	234267.Acid_5592	7.999e-66	232.0	COG1845@1|root,COG1845@2|Bacteria,3Y5GJ@57723|Acidobacteria	57723|Acidobacteria	C	Cytochrome c oxidase subunit III	-	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD1_k127_3771014_6	234267.Acid_6511	5.789e-151	494.0	COG2234@1|root,COG2234@2|Bacteria,3Y3S9@57723|Acidobacteria	57723|Acidobacteria	S	PA domain	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD1_k127_3771014_3	1382359.JIAL01000001_gene119	3.323e-189	614.0	COG0143@1|root,COG0143@2|Bacteria,3Y2I2@57723|Acidobacteria,2JIC5@204432|Acidobacteriia	204432|Acidobacteriia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD1_k127_3771014_14	414684.RC1_1170	7.004e-76	262.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,2JR2C@204441|Rhodospirillales	204441|Rhodospirillales	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_3774502_8	1379698.RBG1_1C00001G1080	9.676e-89	322.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD1_k127_3774502_7	1379698.RBG1_1C00001G1080	8.413e-97	349.0	COG2091@1|root,COG2091@2|Bacteria,2NQPA@2323|unclassified Bacteria	2|Bacteria	H	lysine biosynthetic process via aminoadipic acid	-	-	-	-	-	-	-	-	-	-	-	-	CBM9_1
HKD1_k127_3774502_25	573370.DMR_06780	1.786e-05	52.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,42NEU@68525|delta/epsilon subdivisions,2WM5E@28221|Deltaproteobacteria,2M8NR@213115|Desulfovibrionales	28221|Deltaproteobacteria	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_3774502_17	1047013.AQSP01000098_gene2565	3.452e-26	121.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	ko:K05385	ko00196,ko01100,map00196,map01100	-	-	-	ko00000,ko00001,ko00194	-	-	-	HEAT_2
HKD1_k127_3774502_22	639030.JHVA01000001_gene1848	2.834e-13	83.0	COG1413@1|root,COG1413@2|Bacteria,3Y7PB@57723|Acidobacteria	57723|Acidobacteria	C	HEAT repeats	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD1_k127_3774502_15	1242864.D187_002705	9.304e-32	132.0	COG1595@1|root,COG1595@2|Bacteria,1MX7T@1224|Proteobacteria,42URE@68525|delta/epsilon subdivisions	1224|Proteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_3774502_20	1502851.FG93_05200	7.819e-17	85.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U76I@28211|Alphaproteobacteria,3JYR4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	KT	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_3774502_27	1045855.DSC_06015	0.0005209	50.0	2AQ2A@1|root,31F7E@2|Bacteria,1QCMG@1224|Proteobacteria,1T8CS@1236|Gammaproteobacteria,1XAFU@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3774502_18	234267.Acid_1488	1.491e-22	103.0	COG3682@1|root,COG3682@2|Bacteria,3Y8QA@57723|Acidobacteria	57723|Acidobacteria	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD1_k127_3774502_26	1223545.GS4_26_01280	0.0003644	52.0	COG0501@1|root,COG0501@2|Bacteria,2GM27@201174|Actinobacteria,4GBXB@85026|Gordoniaceae	201174|Actinobacteria	O	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD1_k127_3774502_6	1128421.JAGA01000001_gene2202	4.005e-110	368.0	COG2211@1|root,COG2211@2|Bacteria,2NPEZ@2323|unclassified Bacteria	2|Bacteria	G	Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
HKD1_k127_3774502_19	330084.JNYZ01000017_gene5223	1.048e-20	99.0	COG2119@1|root,COG2119@2|Bacteria,2GNR0@201174|Actinobacteria,4E2WC@85010|Pseudonocardiales	201174|Actinobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_3774502_10	746697.Aeqsu_0762	1.128e-84	288.0	COG4559@1|root,COG4559@2|Bacteria,4NK28@976|Bacteroidetes,1HXCE@117743|Flavobacteriia	976|Bacteroidetes	P	abc transporter (atp-binding protein)	hmuV	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD1_k127_3774502_4	746697.Aeqsu_0761	1.88e-125	410.0	COG0609@1|root,COG0609@2|Bacteria,4NEDU@976|Bacteroidetes,1HZU4@117743|Flavobacteriia	976|Bacteroidetes	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_3774502_9	926562.Oweho_1700	1.761e-88	306.0	COG4558@1|root,COG4558@2|Bacteria,4NH3G@976|Bacteroidetes,1HYBA@117743|Flavobacteriia,2PC0C@246874|Cryomorphaceae	976|Bacteroidetes	P	ABC-type hemin transport system, periplasmic component	hmuT	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_3774502_0	234267.Acid_3209	0.0	1443.0	COG1629@1|root,COG4771@2|Bacteria,3Y4C9@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_3774502_2	237368.SCABRO_03745	1.608e-194	618.0	COG1012@1|root,COG1012@2|Bacteria,2IXV2@203682|Planctomycetes	203682|Planctomycetes	C	Belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.39	ko:K00128,ko:K00146	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00360,ko00380,ko00410,ko00561,ko00620,ko00625,ko00643,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00360,map00380,map00410,map00561,map00620,map00625,map00643,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02536,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_3774502_5	1227739.Hsw_2761	6.723e-120	392.0	28HGI@1|root,2Z7SC@2|Bacteria,4NJUF@976|Bacteroidetes,47PDE@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3774502_13	504728.K649_00340	2.613e-48	181.0	COG0739@1|root,COG0739@2|Bacteria,1WK9B@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	PFAM Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD1_k127_3774502_21	497964.CfE428DRAFT_1606	3.815e-16	79.0	COG1598@1|root,COG1598@2|Bacteria	2|Bacteria	N	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_3774502_1	497964.CfE428DRAFT_1607	0.0	1296.0	COG1048@1|root,COG1048@2|Bacteria,46SFS@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_3774502_24	1170562.Cal6303_0902	1.549e-09	64.0	2EE59@1|root,337ZW@2|Bacteria,1G955@1117|Cyanobacteria,1HNGZ@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3774502_3	234267.Acid_3557	2.989e-136	441.0	COG1073@1|root,COG1073@2|Bacteria	2|Bacteria	S	thiolester hydrolase activity	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_3774502_16	1267005.KB911260_gene3537	1.549e-29	127.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,3N8KU@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	ppiA	-	5.2.1.8	ko:K01802,ko:K03767,ko:K03768,ko:K09565	ko01503,ko04020,ko04022,ko04217,ko05012,ko05016,ko05145,map01503,map04020,map04022,map04217,map05012,map05016,map05145	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD1_k127_3774502_12	484019.THA_1655	3.062e-52	188.0	COG1490@1|root,COG1490@2|Bacteria,2GCYQ@200918|Thermotogae	200918|Thermotogae	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	GO:0002161,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006399,GO:0006450,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0034641,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044424,GO:0044464,GO:0046483,GO:0051499,GO:0051500,GO:0052689,GO:0065007,GO:0065008,GO:0071704,GO:0090304,GO:0106074,GO:0140098,GO:0140101,GO:1901360	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD1_k127_3774502_11	649638.Trad_2700	4.773e-70	246.0	COG4221@1|root,COG4221@2|Bacteria,1WIDQ@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_3798560_3	1173022.Cri9333_3473	2.197e-247	784.0	COG0058@1|root,COG0058@2|Bacteria,1G1HB@1117|Cyanobacteria,1HA6X@1150|Oscillatoriales	1117|Cyanobacteria	G	Protein of unknown function (DUF3417)	glgP	-	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	-	DUF3417,Phosphorylase
HKD1_k127_3798560_20	159087.Daro_1928	2.128e-63	222.0	COG2110@1|root,COG2110@2|Bacteria,1RCWP@1224|Proteobacteria,2VRGS@28216|Betaproteobacteria,2KWIF@206389|Rhodocyclales	206389|Rhodocyclales	S	Appr-1'-p processing enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD1_k127_3798560_29	639030.JHVA01000001_gene673	1.302e-22	107.0	2A9J8@1|root,30YRM@2|Bacteria,3Y4IZ@57723|Acidobacteria,2JJDB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3798560_7	1382359.JIAL01000001_gene1050	5.999e-199	642.0	COG0480@1|root,COG0480@2|Bacteria,3Y2RR@57723|Acidobacteria,2JI85@204432|Acidobacteriia	204432|Acidobacteriia	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_3798560_37	29486.NJ56_00315	3.005e-06	57.0	COG3678@1|root,COG3678@2|Bacteria,1RIYB@1224|Proteobacteria,1S628@1236|Gammaproteobacteria,41FF0@629|Yersinia	1236|Gammaproteobacteria	NPTU	to Periplasmic repressor of cpx regulon by interaction with CpxA, rescue from transitory stresses of Enterobacteriaceae UniRef RepID A8GLB2_SERP5	cpxP	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006355,GO:0008150,GO:0009889,GO:0009890,GO:0009892,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0019219,GO:0019222,GO:0030288,GO:0030313,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031975,GO:0042597,GO:0042802,GO:0044464,GO:0045892,GO:0045934,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051082,GO:0051171,GO:0051172,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K06006	-	-	-	-	ko00000,ko03110	-	-	-	LTXXQ
HKD1_k127_3798560_4	1340493.JNIF01000003_gene3519	1.38e-239	775.0	COG1629@1|root,COG4771@2|Bacteria,3Y3HA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_3798560_36	29078.XP_008157969.1	1.504e-06	63.0	COG5045@1|root,COG5069@1|root,KOG0516@2759|Eukaryota,KOG3344@2759|Eukaryota,38EE9@33154|Opisthokonta,3BA4T@33208|Metazoa,3CRBY@33213|Bilateria,486GF@7711|Chordata,48YP9@7742|Vertebrata,3J2VE@40674|Mammalia,4KXCV@9397|Chiroptera	33208|Metazoa	Z	Plectin repeat	PLEC	GO:0000003,GO:0000226,GO:0000235,GO:0000902,GO:0000904,GO:0001558,GO:0001578,GO:0001700,GO:0001709,GO:0001763,GO:0002009,GO:0002020,GO:0002165,GO:0003674,GO:0003779,GO:0004857,GO:0004866,GO:0004869,GO:0005198,GO:0005200,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005818,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005876,GO:0005881,GO:0005886,GO:0005903,GO:0005912,GO:0005924,GO:0005925,GO:0005927,GO:0006915,GO:0006928,GO:0006935,GO:0006996,GO:0007010,GO:0007017,GO:0007026,GO:0007044,GO:0007154,GO:0007267,GO:0007275,GO:0007391,GO:0007399,GO:0007409,GO:0007411,GO:0007417,GO:0007420,GO:0007423,GO:0007424,GO:0007444,GO:0007472,GO:0007475,GO:0007476,GO:0007517,GO:0007552,GO:0007560,GO:0007565,GO:0007584,GO:0008017,GO:0008037,GO:0008038,GO:0008092,GO:0008150,GO:0008219,GO:0008307,GO:0008361,GO:0008587,GO:0009605,GO:0009653,GO:0009790,GO:0009791,GO:0009792,GO:0009886,GO:0009887,GO:0009888,GO:0009892,GO:0009925,GO:0009987,GO:0009991,GO:0010466,GO:0010468,GO:0010605,GO:0010629,GO:0010639,GO:0010720,GO:0010769,GO:0010770,GO:0010941,GO:0010942,GO:0010951,GO:0010955,GO:0010975,GO:0010976,GO:0012501,GO:0015630,GO:0015631,GO:0016020,GO:0016043,GO:0016198,GO:0016199,GO:0016203,GO:0016204,GO:0016319,GO:0016323,GO:0016324,GO:0016331,GO:0016358,GO:0016528,GO:0019222,GO:0019899,GO:0022008,GO:0022414,GO:0022603,GO:0022604,GO:0022607,GO:0023052,GO:0030016,GO:0030029,GO:0030030,GO:0030036,GO:0030054,GO:0030055,GO:0030056,GO:0030154,GO:0030162,GO:0030175,GO:0030182,GO:0030234,GO:0030307,GO:0030414,GO:0030424,GO:0030426,GO:0030427,GO:0030506,GO:0030516,GO:0030716,GO:0030855,GO:0030865,GO:0031110,GO:0031111,GO:0031114,GO:0031122,GO:0031175,GO:0031323,GO:0031324,GO:0031344,GO:0031346,GO:0031581,GO:0031667,GO:0032268,GO:0032269,GO:0032501,GO:0032502,GO:0032504,GO:0032535,GO:0032886,GO:0032989,GO:0032990,GO:0032991,GO:0033043,GO:0033267,GO:0034329,GO:0034330,GO:0035107,GO:0035114,GO:0035120,GO:0035146,GO:0035147,GO:0035148,GO:0035149,GO:0035152,GO:0035220,GO:0035239,GO:0035295,GO:0035371,GO:0035375,GO:0040008,GO:0040011,GO:0042221,GO:0042330,GO:0042383,GO:0042981,GO:0042995,GO:0043005,GO:0043027,GO:0043028,GO:0043034,GO:0043065,GO:0043066,GO:0043067,GO:0043068,GO:0043069,GO:0043086,GO:0043154,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043242,GO:0043244,GO:0043281,GO:0043292,GO:0043622,GO:0043900,GO:0043902,GO:0044085,GO:0044087,GO:0044089,GO:0044092,GO:0044295,GO:0044422,GO:0044424,GO:0044425,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044459,GO:0044463,GO:0044464,GO:0044703,GO:0044706,GO:0045111,GO:0045165,GO:0045169,GO:0045177,GO:0045178,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0045773,GO:0045861,GO:0045927,GO:0047485,GO:0048468,GO:0048471,GO:0048513,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048563,GO:0048569,GO:0048598,GO:0048609,GO:0048638,GO:0048639,GO:0048646,GO:0048666,GO:0048667,GO:0048699,GO:0048707,GO:0048729,GO:0048731,GO:0048736,GO:0048737,GO:0048754,GO:0048812,GO:0048813,GO:0048856,GO:0048858,GO:0048869,GO:0050767,GO:0050769,GO:0050770,GO:0050772,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051171,GO:0051172,GO:0051239,GO:0051240,GO:0051246,GO:0051248,GO:0051336,GO:0051346,GO:0051489,GO:0051491,GO:0051493,GO:0051494,GO:0051704,GO:0051960,GO:0051962,GO:0052547,GO:0052548,GO:0060255,GO:0060284,GO:0060322,GO:0060378,GO:0060429,GO:0060446,GO:0060491,GO:0060538,GO:0060541,GO:0060548,GO:0060562,GO:0061061,GO:0061134,GO:0061135,GO:0061138,GO:0061387,GO:0061564,GO:0065007,GO:0065008,GO:0065009,GO:0070161,GO:0070507,GO:0070613,GO:0071840,GO:0071944,GO:0080090,GO:0080154,GO:0089720,GO:0090066,GO:0090727,GO:0097179,GO:0097340,GO:0097341,GO:0097435,GO:0097458,GO:0097485,GO:0098590,GO:0098772,GO:0098858,GO:0098862,GO:0099080,GO:0099081,GO:0099512,GO:0099513,GO:0120025,GO:0120032,GO:0120034,GO:0120035,GO:0120036,GO:0120038,GO:0120039,GO:0150034,GO:1901879,GO:1901880,GO:1902903,GO:1902904,GO:1903317,GO:1903318,GO:1904090,GO:1904747,GO:1904748,GO:1905516,GO:1990001,GO:1990752,GO:2000026,GO:2000116,GO:2000117,GO:2000241,GO:2000243	-	ko:K10382,ko:K10388,ko:K19827	-	-	-	-	ko00000,ko04812	-	-	-	CH,GAS2,Plectin,S10_plectin,Spectrin
HKD1_k127_3798560_6	649349.Lbys_2672	2.429e-209	667.0	COG0726@1|root,COG0726@2|Bacteria,4NFJP@976|Bacteroidetes,47JTA@768503|Cytophagia	976|Bacteroidetes	G	Glycosyl hydrolase family 9	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9
HKD1_k127_3798560_14	225937.HP15_3154	7.172e-112	366.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,1RQNI@1236|Gammaproteobacteria,4643V@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Class II aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD1_k127_3798560_26	1144275.COCOR_00369	1.035e-28	123.0	COG3386@1|root,COG3386@2|Bacteria,1NFEJ@1224|Proteobacteria,43BX0@68525|delta/epsilon subdivisions,2X77S@28221|Deltaproteobacteria,2YVY8@29|Myxococcales	28221|Deltaproteobacteria	G	PFAM SMP-30 Gluconolaconase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3798560_21	697282.Mettu_4198	2.029e-61	215.0	COG2764@1|root,COG2764@2|Bacteria,1RF5T@1224|Proteobacteria,1RUA2@1236|Gammaproteobacteria,1XGHE@135618|Methylococcales	135618|Methylococcales	S	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3798560_31	749927.AMED_8982	4.593e-22	110.0	COG0346@1|root,COG0346@2|Bacteria,2H5Y5@201174|Actinobacteria,4EBMJ@85010|Pseudonocardiales	201174|Actinobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3798560_27	1379698.RBG1_1C00001G0617	1.771e-26	124.0	COG2764@1|root,COG2764@2|Bacteria	2|Bacteria	E	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3798560_32	66692.ABC1419	8.179e-22	109.0	COG2764@1|root,COG2764@2|Bacteria,1TQ8R@1239|Firmicutes,4HYS4@91061|Bacilli,1ZNY1@1386|Bacillus	91061|Bacilli	S	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3798560_23	204669.Acid345_3132	1.565e-39	154.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_3798560_25	1123253.AUBD01000009_gene2228	8.097e-29	133.0	COG2374@1|root,COG2374@2|Bacteria,1MX52@1224|Proteobacteria,1RRGN@1236|Gammaproteobacteria,1X3H2@135614|Xanthomonadales	135614|Xanthomonadales	Q	Lamin Tail Domain	nucH	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Calx-beta,Exo_endo_phos,LTD
HKD1_k127_3798560_15	497965.Cyan7822_0638	4.228e-104	347.0	COG0053@1|root,COG0053@2|Bacteria,1G361@1117|Cyanobacteria,3KHNP@43988|Cyanothece	1117|Cyanobacteria	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD1_k127_3798560_0	1267534.KB906758_gene2265	0.0	1005.0	COG2936@1|root,COG2936@2|Bacteria,3Y33N@57723|Acidobacteria	57723|Acidobacteria	S	Hydrolase CocE NonD family	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
HKD1_k127_3798560_8	1515613.HQ37_06870	4.499e-195	619.0	COG0442@1|root,COG0442@2|Bacteria,4NEAF@976|Bacteroidetes,2FMZT@200643|Bacteroidia,22X3K@171551|Porphyromonadaceae	976|Bacteroidetes	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	GO:0003674,GO:0003824,GO:0004812,GO:0004827,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006433,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0017101,GO:0019538,GO:0019752,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HKD1_k127_3798560_28	204669.Acid345_3466	9.307e-24	102.0	2DS5Y@1|root,33EPX@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3798560_16	1134413.ANNK01000103_gene885	1.687e-96	317.0	28H95@1|root,2Z7KY@2|Bacteria,1TQTR@1239|Firmicutes,4HB82@91061|Bacilli,1ZDT7@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF4256)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4256
HKD1_k127_3798560_18	196490.AUEZ01000004_gene4064	1.446e-69	237.0	COG0346@1|root,COG0346@2|Bacteria,1RE6F@1224|Proteobacteria,2UBFM@28211|Alphaproteobacteria,3JZSQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_3798560_13	1198452.Jab_2c25350	6.418e-120	401.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2WA04@28216|Betaproteobacteria,47500@75682|Oxalobacteraceae	28216|Betaproteobacteria	E	Peptidase dimerisation domain	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3798560_35	234267.Acid_3736	4.865e-13	82.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	ko:K14194	ko05150,map05150	-	-	-	ko00000,ko00001	-	-	-	CarboxypepD_reg,DUF11,GSu_C4xC__C2xCH,SdrD_B
HKD1_k127_3798560_30	234267.Acid_1525	2.831e-22	112.0	COG4932@1|root,COG4932@2|Bacteria,3Y53F@57723|Acidobacteria	57723|Acidobacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_3798560_10	1267533.KB906733_gene3127	1.038e-179	591.0	COG1629@1|root,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_3798560_1	443143.GM18_0728	6.484e-298	923.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,42MMK@68525|delta/epsilon subdivisions,2WJC1@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM ABC transporter related	yjjK	-	3.6.3.25	ko:K06020	-	-	-	-	ko00000,ko01000	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_3798560_24	448385.sce6756	4.134e-29	128.0	2E0EH@1|root,2ZZNI@2|Bacteria,1Q8YZ@1224|Proteobacteria,438YN@68525|delta/epsilon subdivisions,2X441@28221|Deltaproteobacteria,2YY76@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3798560_19	1379270.AUXF01000005_gene535	8.268e-64	237.0	COG1680@1|root,COG1680@2|Bacteria,1ZUKU@142182|Gemmatimonadetes	142182|Gemmatimonadetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_3798560_12	357808.RoseRS_2336	1.064e-128	415.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3798560_34	1279009.ADICEAN_02616	1.485e-13	76.0	COG4334@1|root,COG4334@2|Bacteria,4NSAC@976|Bacteroidetes	976|Bacteroidetes	S	Uncharacterized protein conserved in bacteria (DUF2255)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2255
HKD1_k127_3798560_5	234267.Acid_0926	1.973e-239	751.0	COG1473@1|root,COG1473@2|Bacteria	2|Bacteria	S	N-acetyldiaminopimelate deacetylase activity	-	-	-	ko:K12941	-	-	-	-	ko00000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3798560_17	1144275.COCOR_07092	8.818e-90	307.0	COG4447@1|root,COG4447@2|Bacteria,1RI56@1224|Proteobacteria	1224|Proteobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3798560_9	1382359.JIAL01000001_gene536	2.243e-194	623.0	COG0366@1|root,COG0366@2|Bacteria	2|Bacteria	G	hydrolase activity, hydrolyzing O-glycosyl compounds	gtfB	GO:0005575,GO:0005576	2.4.1.5	ko:K00689	ko00500,ko02020,map00500,map02020	-	R02120,R06066	RC00028	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,CW_binding_1,Glyco_hydro_70
HKD1_k127_3798560_2	682795.AciX8_4155	2.404e-277	873.0	COG3533@1|root,COG3533@2|Bacteria,3Y3WA@57723|Acidobacteria,2JKD6@204432|Acidobacteriia	204432|Acidobacteriia	S	Beta-L-arabinofuranosidase, GH127	-	-	-	ko:K09955	-	-	-	-	ko00000	-	-	-	Glyco_hydro_127
HKD1_k127_3798560_22	1122604.JONR01000009_gene2319	7.093e-60	210.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,1S3T2@1236|Gammaproteobacteria,1X7BR@135614|Xanthomonadales	135614|Xanthomonadales	S	CoA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_2
HKD1_k127_3798560_11	404589.Anae109_0332	1.95e-167	543.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria	1224|Proteobacteria	S	oligopeptide transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD1_k127_3802551_0	204669.Acid345_2187	4.461e-121	400.0	COG4948@1|root,COG4948@2|Bacteria,3Y2QQ@57723|Acidobacteria,2JITG@204432|Acidobacteriia	204432|Acidobacteriia	M	Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB)	menC	-	4.2.1.113	ko:K02549	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R04031	RC01053	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_3802551_1	1173021.ALWA01000020_gene220	5.22e-61	226.0	COG0436@1|root,COG0436@2|Bacteria,1G202@1117|Cyanobacteria	1117|Cyanobacteria	E	Aminotransferase class I and II	-	-	-	ko:K10907	-	-	-	-	ko00000,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3802551_3	293826.Amet_2631	1.203e-17	94.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,36DZB@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD1_k127_3802551_2	869210.Marky_1791	1.759e-42	166.0	COG3375@1|root,COG3375@2|Bacteria,1WI6K@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	M	carboxylic acid catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_3814525_35	706587.Desti_1655	9.243e-05	46.0	COG1943@1|root,COG1943@2|Bacteria,1NA94@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_3814525_30	1304875.JAFZ01000002_gene71	6.346e-15	88.0	COG0265@1|root,COG0265@2|Bacteria,3TACF@508458|Synergistetes	508458|Synergistetes	M	TIGRFAM periplasmic serine protease, Do DeqQ family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_3814525_22	720554.Clocl_2649	9.132e-35	141.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,3WIW4@541000|Ruminococcaceae	186801|Clostridia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_3814525_6	1267533.KB906733_gene3489	6.421e-120	394.0	COG0189@1|root,COG0189@2|Bacteria,3Y37D@57723|Acidobacteria,2JI05@204432|Acidobacteriia	204432|Acidobacteriia	HJ	ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3814525_33	1217652.F954_01757	5.427e-05	55.0	COG3063@1|root,COG3063@2|Bacteria,1N1YA@1224|Proteobacteria,1S4Q6@1236|Gammaproteobacteria,3NJ69@468|Moraxellaceae	1236|Gammaproteobacteria	NU	Tetratricopeptide repeat	pilF	-	-	ko:K02656	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	TPR_16,TPR_17,TPR_8
HKD1_k127_3814525_20	215803.DB30_6971	2.271e-37	155.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,438D4@68525|delta/epsilon subdivisions,2X3NA@28221|Deltaproteobacteria,2YWMP@29|Myxococcales	28221|Deltaproteobacteria	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD1_k127_3814525_19	1340493.JNIF01000003_gene2787	7.034e-42	162.0	COG1595@1|root,COG1595@2|Bacteria,3Y4IW@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_3814525_37	696281.Desru_1377	0.000408	52.0	COG5662@1|root,COG5662@2|Bacteria,1U216@1239|Firmicutes,25N56@186801|Clostridia,2631J@186807|Peptococcaceae	186801|Clostridia	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
HKD1_k127_3814525_28	1121459.AQXE01000012_gene2314	8.652e-16	85.0	COG1437@1|root,COG1437@2|Bacteria,1N326@1224|Proteobacteria,42U83@68525|delta/epsilon subdivisions,2WQQR@28221|Deltaproteobacteria,2MBY3@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM Adenylate cyclase	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
HKD1_k127_3814525_14	1047013.AQSP01000052_gene2599	1.936e-72	261.0	COG1668@1|root,COG1668@2|Bacteria,2NPCQ@2323|unclassified Bacteria	2|Bacteria	CP	ABC-2 family transporter protein	natB	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD1_k127_3814525_9	1382359.JIAL01000001_gene3045	2.204e-88	301.0	COG4152@1|root,COG4152@2|Bacteria,3Y2NV@57723|Acidobacteria,2JHVX@204432|Acidobacteriia	204432|Acidobacteriia	S	pfam abc	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_3814525_27	204669.Acid345_3607	2.976e-16	81.0	COG1254@1|root,COG1254@2|Bacteria,3Y55N@57723|Acidobacteria,2JJSV@204432|Acidobacteriia	204432|Acidobacteriia	C	Acylphosphatase	-	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD1_k127_3814525_21	318996.AXAZ01000027_gene1590	1.714e-35	142.0	29CWT@1|root,2ZZUX@2|Bacteria,1REF2@1224|Proteobacteria,2U7K7@28211|Alphaproteobacteria,3JSSE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2585)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2585
HKD1_k127_3814525_15	1341151.ASZU01000010_gene1916	1.851e-70	247.0	COG3253@1|root,COG3253@2|Bacteria,1VZPB@1239|Firmicutes,4HZ7E@91061|Bacilli,27B36@186824|Thermoactinomycetaceae	91061|Bacilli	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD1_k127_3814525_32	1128421.JAGA01000002_gene1632	1.037e-09	65.0	COG1276@1|root,COG2010@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2010@2|Bacteria,COG2372@2|Bacteria,2NPS1@2323|unclassified Bacteria	2|Bacteria	P	Evidence 5 No homology to any previously reported sequences	ycnJ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07156,ko:K07245,ko:K14166	-	-	-	-	ko00000,ko02000	9.B.62.1,9.B.62.2	-	-	CopC,CopD,Cytochrome_CBB3,YtkA
HKD1_k127_3814525_34	56780.SYN_03595	5.68e-05	48.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,42PXQ@68525|delta/epsilon subdivisions,2WKHU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_3814525_17	1112217.PPL19_17725	8.591e-57	210.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,1RNS2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	GO:0000041,GO:0003674,GO:0005215,GO:0005381,GO:0005385,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0006810,GO:0006811,GO:0006812,GO:0006826,GO:0006829,GO:0006873,GO:0006875,GO:0006876,GO:0006882,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015086,GO:0015093,GO:0015291,GO:0015318,GO:0015341,GO:0015562,GO:0015684,GO:0015691,GO:0016020,GO:0019725,GO:0022804,GO:0022857,GO:0022883,GO:0022890,GO:0030001,GO:0030003,GO:0034220,GO:0034755,GO:0042592,GO:0042802,GO:0044464,GO:0046583,GO:0046873,GO:0046915,GO:0046916,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0055065,GO:0055069,GO:0055073,GO:0055076,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0070574,GO:0070838,GO:0071577,GO:0071944,GO:0072503,GO:0072507,GO:0072509,GO:0072511,GO:0098655,GO:0098660,GO:0098662,GO:0098771,GO:1903874	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
HKD1_k127_3814525_31	1121920.AUAU01000005_gene1082	4.859e-14	83.0	COG3595@1|root,COG3595@2|Bacteria,3Y5MS@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD1_k127_3814525_38	1162668.LFE_2259	0.0005554	51.0	COG0457@1|root,COG0457@2|Bacteria,3J17M@40117|Nitrospirae	40117|Nitrospirae	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	TPR_19
HKD1_k127_3814525_2	234267.Acid_5431	6.307e-193	647.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_3814525_10	1267535.KB906767_gene5053	1.482e-74	261.0	COG2367@1|root,COG2367@2|Bacteria,3Y3UF@57723|Acidobacteria	57723|Acidobacteria	V	Beta-lactamase enzyme family	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HKD1_k127_3814525_0	204669.Acid345_0395	6.896e-218	725.0	COG1629@1|root,COG4771@2|Bacteria,3Y2GB@57723|Acidobacteria,2JP02@204432|Acidobacteriia	204432|Acidobacteriia	P	CarboxypepD_reg-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_3814525_4	269799.Gmet_0138	3.137e-136	449.0	COG5316@1|root,COG5316@2|Bacteria,1QCVP@1224|Proteobacteria,42QA4@68525|delta/epsilon subdivisions,2WKD1@28221|Deltaproteobacteria,43SDE@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139,DUF4140
HKD1_k127_3814525_36	204669.Acid345_4477	0.0001157	51.0	COG2823@1|root,COG2823@2|Bacteria	2|Bacteria	S	hyperosmotic response	osmY_1	-	-	ko:K04065	-	-	-	-	ko00000	-	-	-	BON,CBS
HKD1_k127_3814525_24	682795.AciX8_2149	7.593e-32	143.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,3Y2VC@57723|Acidobacteria,2JHR2@204432|Acidobacteriia	204432|Acidobacteriia	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD1_k127_3814525_13	204669.Acid345_2341	1.766e-72	267.0	COG0815@1|root,COG0815@2|Bacteria,3Y4FZ@57723|Acidobacteria,2JKVC@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD1_k127_3814525_5	1267535.KB906767_gene4419	2.75e-121	398.0	COG1186@1|root,COG1186@2|Bacteria,3Y2ZM@57723|Acidobacteria,2JIGW@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_3814525_1	1267533.KB906735_gene4841	1.134e-194	634.0	COG1674@1|root,COG1674@2|Bacteria,3Y3CJ@57723|Acidobacteria,2JHRN@204432|Acidobacteriia	204432|Acidobacteriia	D	Ftsk_gamma	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_3814525_29	760568.Desku_2741	1.691e-15	80.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,262CC@186807|Peptococcaceae	186801|Clostridia	L	TIGRFAM Competence protein ComEA, helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HKD1_k127_3814525_12	204669.Acid345_1043	2.033e-73	264.0	COG2379@1|root,COG2379@2|Bacteria,3Y2XC@57723|Acidobacteria,2JID2@204432|Acidobacteriia	204432|Acidobacteriia	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HKD1_k127_3814525_25	243365.CV_3182	4.131e-25	111.0	COG5553@1|root,COG5553@2|Bacteria,1NXEP@1224|Proteobacteria	1224|Proteobacteria	C	Cysteine dioxygenase type I	-	-	1.13.11.20	ko:K00456	ko00270,ko00430,ko01100,map00270,map00430,map01100	-	R00893	RC00404	ko00000,ko00001,ko01000	-	-	-	CDO_I
HKD1_k127_3814525_11	234267.Acid_6424	2.559e-74	281.0	COG0658@1|root,COG2333@1|root,COG0658@2|Bacteria,COG2333@2|Bacteria,3Y3VQ@57723|Acidobacteria	57723|Acidobacteria	S	DNA internalization-related competence protein ComEC Rec2	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Competence,DUF4131,Lactamase_B
HKD1_k127_3814525_16	234267.Acid_5841	5.49e-68	247.0	COG2265@1|root,COG2265@2|Bacteria,3Y3SF@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_3814525_23	278963.ATWD01000001_gene3585	3.401e-32	135.0	COG3468@1|root,COG3468@2|Bacteria,3Y4NE@57723|Acidobacteria,2JJBC@204432|Acidobacteriia	204432|Acidobacteriia	MU	outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3814525_8	204669.Acid345_0136	6.819e-95	319.0	COG1521@1|root,COG1521@2|Bacteria,3Y398@57723|Acidobacteria,2JI76@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD1_k127_3814525_7	927677.ALVU02000002_gene173	2.367e-114	382.0	COG1819@1|root,COG1819@2|Bacteria,1G3IM@1117|Cyanobacteria	1117|Cyanobacteria	CG	UDP-glucoronosyl and UDP-glucosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tran_28_C,Glyco_transf_28,UDPGT
HKD1_k127_3814525_18	1122609.AUGT01000013_gene4183	9.403e-43	166.0	COG0340@1|root,COG0340@2|Bacteria,2GN8Q@201174|Actinobacteria,4DQT5@85009|Propionibacteriales	201174|Actinobacteria	H	Biotin/lipoate A/B protein ligase family	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB
HKD1_k127_3814525_3	1183438.GKIL_3588	5.292e-190	606.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	pgcp	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD1_k127_384054_0	450851.PHZ_c2242	3.81e-36	146.0	COG0463@1|root,COG0463@2|Bacteria,1MV7X@1224|Proteobacteria,2TYQ8@28211|Alphaproteobacteria,2KIIC@204458|Caulobacterales	204458|Caulobacterales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_3878722_8	204669.Acid345_3630	1.895e-97	333.0	COG0772@1|root,COG0772@2|Bacteria,3Y330@57723|Acidobacteria,2JHW0@204432|Acidobacteriia	204432|Acidobacteriia	D	Belongs to the SEDS family	-	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_3878722_9	443143.GM18_3887	7.074e-97	328.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,42ME1@68525|delta/epsilon subdivisions,2WJNY@28221|Deltaproteobacteria,43UB0@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_3878722_5	234267.Acid_7310	3.01e-163	526.0	COG0773@1|root,COG0773@2|Bacteria,3Y304@57723|Acidobacteria	57723|Acidobacteria	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3878722_14	1123313.ATUT01000015_gene659	6.048e-51	192.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,3VNQM@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Cell wall formation	murB	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_4,MurB_C
HKD1_k127_3878722_24	639030.JHVA01000001_gene1378	3.298e-11	75.0	COG1589@1|root,COG1589@2|Bacteria,3Y3BQ@57723|Acidobacteria,2JIZS@204432|Acidobacteriia	204432|Acidobacteriia	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD1_k127_3878722_7	316067.Geob_0785	2.28e-118	393.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,42MS2@68525|delta/epsilon subdivisions,2WIQ0@28221|Deltaproteobacteria,43SXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD1_k127_3878722_6	1499967.BAYZ01000069_gene1912	2.539e-125	412.0	COG0206@1|root,COG0206@2|Bacteria,2NNSU@2323|unclassified Bacteria	2|Bacteria	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	GO:0000166,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0003924,GO:0005488,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0017076,GO:0017111,GO:0019001,GO:0032153,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032561,GO:0035639,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0051301,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_3878722_22	1340493.JNIF01000003_gene2806	6.202e-21	100.0	COG1923@1|root,COG1923@2|Bacteria,3Y5JI@57723|Acidobacteria	57723|Acidobacteria	S	Hfq protein	-	-	-	-	-	-	-	-	-	-	-	-	Hfq
HKD1_k127_3878722_11	555079.Toce_0654	1.536e-88	304.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,42FJX@68295|Thermoanaerobacterales	186801|Clostridia	C	Belongs to the PdxA family	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_3878722_23	330214.NIDE2020	4.523e-17	85.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3878722_27	267608.RSc2310	6.573e-05	53.0	COG2165@1|root,COG2165@2|Bacteria,1RDX2@1224|Proteobacteria,2VR66@28216|Betaproteobacteria,1K7U7@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Type II secretion system (T2SS), protein G	-	-	-	ko:K02456	ko03070,ko05111,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02044	3.A.15	-	-	N_methyl,T2SSG
HKD1_k127_3878722_4	1318628.MARLIPOL_07224	1.073e-167	584.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria,465V0@72275|Alteromonadaceae	1236|Gammaproteobacteria	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2235,RHS,RHS_repeat
HKD1_k127_3878722_20	338963.Pcar_2316	2.772e-31	139.0	COG0745@1|root,COG0745@2|Bacteria,1N1N5@1224|Proteobacteria,42UP1@68525|delta/epsilon subdivisions,2WQAF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_3878722_2	234267.Acid_7639	5.502e-182	582.0	COG3344@1|root,COG3344@2|Bacteria,3Y46K@57723|Acidobacteria	57723|Acidobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986	-	-	-	-	ko00000,ko01000	-	-	-	GIIM,RVT_1,RVT_N
HKD1_k127_3878722_0	264732.Moth_0532	3.107e-291	919.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,42ET0@68295|Thermoanaerobacterales	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_3878722_12	266117.Rxyl_0106	8.414e-72	252.0	COG0157@1|root,COG0157@2|Bacteria,2GV9P@201174|Actinobacteria,4CQ2N@84995|Rubrobacteria	84995|Rubrobacteria	H	Quinolinate phosphoribosyl transferase, C-terminal domain	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_3878722_21	871963.Desdi_3275	1.809e-21	97.0	COG1975@1|root,COG1975@2|Bacteria,1VFRE@1239|Firmicutes,24U4F@186801|Clostridia	186801|Clostridia	O	XdhC and CoxI family	-	-	-	-	-	-	-	-	-	-	-	-	XdhC_CoxI
HKD1_k127_3878722_18	1120973.AQXL01000113_gene794	1.184e-33	132.0	COG4539@1|root,COG4539@2|Bacteria,1VJFX@1239|Firmicutes,4HQE3@91061|Bacilli,27A12@186823|Alicyclobacillaceae	91061|Bacilli	S	Protein of unknown function (DUF962)	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HKD1_k127_3878722_17	646529.Desaci_1918	7.868e-37	153.0	COG1975@1|root,COG1975@2|Bacteria,1URM5@1239|Firmicutes,24AHV@186801|Clostridia,2617B@186807|Peptococcaceae	186801|Clostridia	O	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD1_k127_3878722_13	1379270.AUXF01000006_gene150	1.616e-54	197.0	2DEWU@1|root,2ZPJP@2|Bacteria,1ZUFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3878722_10	1183438.GKIL_3324	3.694e-89	310.0	COG0477@1|root,COG2814@2|Bacteria,1G2N2@1117|Cyanobacteria	1117|Cyanobacteria	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_3878722_15	316274.Haur_2022	1.839e-44	174.0	COG4447@1|root,COG4447@2|Bacteria,2G9IJ@200795|Chloroflexi	200795|Chloroflexi	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3878722_1	395964.KE386496_gene1786	1.058e-203	642.0	COG1012@1|root,COG1012@2|Bacteria,1MVGW@1224|Proteobacteria,2TR9T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.3,1.2.1.68,1.2.99.10	ko:K00128,ko:K00154,ko:K22445	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_3878722_16	1123508.JH636456_gene127	2.697e-39	153.0	COG3467@1|root,COG3467@2|Bacteria	2|Bacteria	T	pyridoxamine 5'-phosphate	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Putative_PNPOx,Pyridox_ox_2
HKD1_k127_3878722_3	204669.Acid345_2858	1.349e-170	569.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	2|Bacteria	I	Phosphate acyltransferases	fadD	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
HKD1_k127_3878722_19	134676.ACPL_2124	5.118e-32	134.0	COG1752@1|root,COG1752@2|Bacteria,2IM69@201174|Actinobacteria	201174|Actinobacteria	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_3878722_25	1415780.JPOG01000001_gene434	2.31e-08	64.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1SEZZ@1236|Gammaproteobacteria,1X8K6@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF374)	-	-	-	-	-	-	-	-	-	-	-	-	DUF374
HKD1_k127_4044628_12	926569.ANT_10990	6.81e-16	90.0	COG0664@1|root,COG0664@2|Bacteria,2G92E@200795|Chloroflexi	200795|Chloroflexi	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_4044628_5	68223.JNZY01000062_gene1107	1.487e-68	248.0	COG0574@1|root,COG0574@2|Bacteria,2IJCV@201174|Actinobacteria	201174|Actinobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
HKD1_k127_4044628_2	68223.JNZY01000062_gene1108	6.994e-125	421.0	COG3848@1|root,COG3848@2|Bacteria,2IE61@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HKD1_k127_4044628_9	497964.CfE428DRAFT_3136	1.935e-26	113.0	2FFTB@1|root,347QG@2|Bacteria,46W3C@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4044628_4	1226994.AMZB01000134_gene4571	4.294e-73	263.0	COG0671@1|root,COG2453@1|root,COG0671@2|Bacteria,COG2453@2|Bacteria,1QSUD@1224|Proteobacteria,1RQAC@1236|Gammaproteobacteria,1YDPJ@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IT	Dual specificity phosphatase, catalytic domain	ynbD	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.1.3.16	ko:K01090	-	-	-	-	ko00000,ko01000	-	-	-	DAGK_cat,DSPc,PAP2_3
HKD1_k127_4044628_1	1122135.KB893134_gene3337	3.478e-186	598.0	COG2267@1|root,COG2267@2|Bacteria,1MWF5@1224|Proteobacteria	1224|Proteobacteria	I	Alpha beta hydrolase	ynbC	GO:0003674,GO:0003824,GO:0005575,GO:0006629,GO:0008150,GO:0008152,GO:0016020,GO:0016298,GO:0016787,GO:0016788,GO:0044238,GO:0071704	-	-	-	-	-	-	-	-	-	-	Hydrolase_4,Methyltransf_20
HKD1_k127_4044628_8	1054213.HMPREF9946_00676	4.707e-41	164.0	COG0204@1|root,COG0204@2|Bacteria	2|Bacteria	I	Acyl-transferase	-	-	2.3.1.51,6.2.1.3	ko:K00655,ko:K01897	ko00061,ko00071,ko00561,ko00564,ko01100,ko01110,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map00561,map00564,map01100,map01110,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086,M00089	R01280,R02241,R09381	RC00004,RC00014,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
HKD1_k127_4044628_7	927677.ALVU02000001_gene4017	4.519e-56	209.0	COG4589@1|root,COG4589@2|Bacteria,1GCQF@1117|Cyanobacteria	1117|Cyanobacteria	S	Belongs to the CDS family	-	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_4044628_10	311403.Arad_3660	6.522e-26	115.0	COG0558@1|root,COG0558@2|Bacteria,1RHFC@1224|Proteobacteria,2UACA@28211|Alphaproteobacteria,4B80S@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	cdp-diacylglycerol--glycerol-3-phosphate	pgsAb	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD1_k127_4044628_3	667632.KB890182_gene876	1.481e-105	361.0	COG1520@1|root,COG1520@2|Bacteria,1NDU1@1224|Proteobacteria,2WBCG@28216|Betaproteobacteria,1K4V0@119060|Burkholderiaceae	1224|Proteobacteria	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ,PQQ_3
HKD1_k127_4044628_6	215803.DB30_4454	1.329e-66	239.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2YYYX@29|Myxococcales	28221|Deltaproteobacteria	T	Magnesium chelatase, subunit ChlI	nla6	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4044628_11	251229.Chro_3250	1.444e-20	104.0	COG1566@1|root,COG1566@2|Bacteria,1GQC6@1117|Cyanobacteria	1117|Cyanobacteria	V	Alternative locus ID	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD1_k127_4044628_0	710685.MycrhN_2535	2.652e-308	976.0	COG2274@1|root,COG2274@2|Bacteria,2GNB5@201174|Actinobacteria,238WK@1762|Mycobacteriaceae	201174|Actinobacteria	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39
HKD1_k127_4071323_3	622637.KE124774_gene3597	2.591e-92	333.0	COG0642@1|root,COG2202@1|root,COG2202@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2TWK2@28211|Alphaproteobacteria,3700W@31993|Methylocystaceae	28211|Alphaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg
HKD1_k127_4071323_4	1040989.AWZU01000008_gene3672	8.891e-56	202.0	COG4566@1|root,COG4566@2|Bacteria,1R47Z@1224|Proteobacteria,2TSQS@28211|Alphaproteobacteria,3JQPG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4071323_7	240016.ABIZ01000001_gene3110	1.856e-26	112.0	COG4566@1|root,COG4566@2|Bacteria,46Z3N@74201|Verrucomicrobia,2IW9Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_4071323_2	497964.CfE428DRAFT_1380	1.16e-139	450.0	COG3239@1|root,COG3239@2|Bacteria	2|Bacteria	I	unsaturated fatty acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD1_k127_4071323_0	395964.KE386496_gene186	5.423e-221	695.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,3NCCR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD1_k127_4071323_1	1283300.ATXB01000001_gene394	1.858e-161	516.0	COG1262@1|root,COG1262@2|Bacteria,1PHCW@1224|Proteobacteria,1RX5H@1236|Gammaproteobacteria,1XGXI@135618|Methylococcales	135618|Methylococcales	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_4071323_8	1122176.KB903587_gene4547	1.515e-25	109.0	2DNGD@1|root,32XCZ@2|Bacteria,4NSM2@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4071323_9	886293.Sinac_2776	2.502e-24	106.0	COG0560@1|root,COG0560@2|Bacteria,2IXZ0@203682|Planctomycetes	203682|Planctomycetes	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_4071323_5	1485545.JQLW01000010_gene1615	4.47e-52	202.0	COG0642@1|root,COG3829@1|root,COG2205@2|Bacteria,COG3829@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,Hpt,PAS_3,PAS_4,PAS_9,PocR,Response_reg,SBP_bac_3
HKD1_k127_4078274_5	497964.CfE428DRAFT_1833	8.448e-79	285.0	COG1075@1|root,COG1075@2|Bacteria,46TIU@74201|Verrucomicrobia	74201|Verrucomicrobia	S	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_4078274_6	521674.Plim_2411	3.326e-48	181.0	COG1226@1|root,32Y28@2|Bacteria,2J0V4@203682|Planctomycetes	203682|Planctomycetes	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_4078274_2	706587.Desti_3024	1.846e-122	401.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,43DPM@68525|delta/epsilon subdivisions,2X9UC@28221|Deltaproteobacteria,2MS8D@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_4078274_7	1161401.ASJA01000003_gene2770	2.175e-44	168.0	COG3409@1|root,COG3409@2|Bacteria,1NP3I@1224|Proteobacteria,2UM8V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidoglycan-binding domain 1 protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4078274_0	330214.NIDE2498	3.525e-248	774.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	CW_binding_1,Lactamase_B
HKD1_k127_4078274_10	1403819.BATR01000092_gene2748	9.124e-07	61.0	2E3AC@1|root,32Y9V@2|Bacteria	2|Bacteria	S	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_4078274_8	1458357.BG58_13115	6.312e-23	113.0	COG1073@1|root,COG1073@2|Bacteria,1R9V1@1224|Proteobacteria,2VTA9@28216|Betaproteobacteria,1KB1N@119060|Burkholderiaceae	28216|Betaproteobacteria	S	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4078274_1	1340493.JNIF01000003_gene4071	7.039e-137	448.0	COG0520@1|root,COG0520@2|Bacteria,3Y4TH@57723|Acidobacteria	57723|Acidobacteria	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_4078274_3	1205680.CAKO01000010_gene3839	1.607e-96	327.0	COG0329@1|root,COG0329@2|Bacteria,1MXM5@1224|Proteobacteria,2TUAG@28211|Alphaproteobacteria,2JRY4@204441|Rhodospirillales	204441|Rhodospirillales	EM	Belongs to the DapA family	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_4083616_34	1121875.KB907552_gene295	1.394e-13	81.0	2DMXX@1|root,32UAZ@2|Bacteria,4NUGJ@976|Bacteroidetes,1I4U9@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4083616_11	1122604.JONR01000025_gene4602	2.935e-125	424.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_4083616_17	38033.XP_001225856.1	1.552e-87	300.0	KOG4155@1|root,KOG4155@2759|Eukaryota,39K60@33154|Opisthokonta,3Q4IX@4751|Fungi,3RMSP@4890|Ascomycota	4751|Fungi	S	N-terminal domain of NWD NACHT-NTPase	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,NACHT_N,WD40
HKD1_k127_4083616_36	1454202.PPBDW_140160___1	2.841e-06	50.0	2DT0U@1|root,33I6V@2|Bacteria,1NMHR@1224|Proteobacteria,1SGK7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4083616_2	290397.Adeh_3947	1.92e-220	700.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,42ME5@68525|delta/epsilon subdivisions,2WKA2@28221|Deltaproteobacteria,2YZII@29|Myxococcales	28221|Deltaproteobacteria	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b,tRNA_edit
HKD1_k127_4083616_26	1379698.RBG1_1C00001G1455	7.866e-44	164.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_4083616_8	639282.DEFDS_0485	5.561e-175	557.0	COG0112@1|root,COG0112@2|Bacteria,2GERI@200930|Deferribacteres	200930|Deferribacteres	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD1_k127_4083616_0	497964.CfE428DRAFT_0990	3.155e-269	841.0	COG0514@1|root,COG0514@2|Bacteria,46S7V@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TIGRFAM ATP-dependent DNA helicase, RecQ family	-	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,Helicase_C,RQC,RecQ_Zn_bind
HKD1_k127_4083616_33	1189619.pgond44_12947	2.105e-14	75.0	COG1943@1|root,COG1943@2|Bacteria,4NQTF@976|Bacteroidetes,1I1DP@117743|Flavobacteriia,4C3MS@83612|Psychroflexus	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_4083616_4	1267535.KB906767_gene4078	1.931e-203	653.0	COG1199@1|root,COG1199@2|Bacteria,3Y3DN@57723|Acidobacteria,2JHJZ@204432|Acidobacteriia	204432|Acidobacteriia	L	HELICc2	-	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,Helicase_C_2
HKD1_k127_4083616_28	335543.Sfum_0003	5.79e-35	138.0	COG0720@1|root,COG0720@2|Bacteria,1RI4P@1224|Proteobacteria,42TJ5@68525|delta/epsilon subdivisions,2WQ2Z@28221|Deltaproteobacteria,2MRZN@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	PFAM 6-pyruvoyl tetrahydropterin synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_4083616_13	1125863.JAFN01000001_gene1446	2.988e-120	401.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4083616_39	1449065.JMLL01000017_gene3961	0.0009762	49.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,43H9I@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	ntrY	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD1_k127_4083616_30	289376.THEYE_A1338	6.354e-25	110.0	COG0784@1|root,COG0784@2|Bacteria	2|Bacteria	T	Response regulator, receiver	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD1_k127_4083616_35	867845.KI911784_gene1200	3.151e-09	61.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,2G7J9@200795|Chloroflexi,37522@32061|Chloroflexia	32061|Chloroflexia	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K11527	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	GAF,GAF_2,HAMP,HATPase_c,HisKA,dCache_1
HKD1_k127_4083616_25	388467.A19Y_1214	1.871e-46	187.0	COG3014@1|root,COG3014@2|Bacteria,1GR3H@1117|Cyanobacteria,1HI7D@1150|Oscillatoriales	1117|Cyanobacteria	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4083616_21	521674.Plim_2823	2.338e-62	229.0	COG4249@1|root,COG4249@2|Bacteria,2J2RG@203682|Planctomycetes	203682|Planctomycetes	S	Agenet domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HKD1_k127_4083616_24	215803.DB30_4074	2.787e-53	192.0	2DGKH@1|root,2ZWDA@2|Bacteria,1Q2F1@1224|Proteobacteria,4380V@68525|delta/epsilon subdivisions,2X3AV@28221|Deltaproteobacteria,2YV6E@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4083616_27	240292.Ava_3740	2.273e-43	165.0	COG3467@1|root,COG3467@2|Bacteria,1G64G@1117|Cyanobacteria,1HS7G@1161|Nostocales	1117|Cyanobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD1_k127_4083616_1	1340493.JNIF01000003_gene2232	7.7e-253	801.0	COG1529@1|root,COG1529@2|Bacteria,3Y3J7@57723|Acidobacteria	57723|Acidobacteria	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.3.99.16	ko:K00256	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_4083616_22	1267535.KB906767_gene2167	4.757e-60	211.0	COG2080@1|root,COG2080@2|Bacteria,3Y5EJ@57723|Acidobacteria,2JN23@204432|Acidobacteriia	204432|Acidobacteriia	C	[2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2,Fer2_2
HKD1_k127_4083616_16	661478.OP10G_4182	2.256e-93	315.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_4083616_3	468059.AUHA01000002_gene1259	3.378e-215	687.0	COG2936@1|root,COG2936@2|Bacteria,4NFFB@976|Bacteroidetes,1IPID@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HKD1_k127_4083616_31	864702.OsccyDRAFT_2681	7.537e-25	104.0	COG1598@1|root,COG1598@2|Bacteria,1G7N4@1117|Cyanobacteria,1HDCI@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM Uncharacterised protein family UPF0150	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD1_k127_4083616_32	43989.cce_2848	1.458e-24	104.0	COG1724@1|root,COG1724@2|Bacteria,1G7S1@1117|Cyanobacteria,3KIRS@43988|Cyanothece	1117|Cyanobacteria	N	PFAM YcfA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD1_k127_4083616_10	1379270.AUXF01000005_gene598	7.125e-139	449.0	COG0334@1|root,COG0334@2|Bacteria,1ZTBQ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_4083616_6	1382359.JIAL01000001_gene2460	3.552e-180	576.0	COG1680@1|root,COG1680@2|Bacteria,3Y3DY@57723|Acidobacteria,2JHVC@204432|Acidobacteriia	204432|Acidobacteriia	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_4083616_29	1184267.A11Q_1677	2.787e-28	125.0	COG0373@1|root,COG0373@2|Bacteria,1QS8F@1224|Proteobacteria,437H1@68525|delta/epsilon subdivisions,2MT7N@213481|Bdellovibrionales,2X2QD@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Glutamyl-tRNAGlu reductase, N-terminal domain	-	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,Shikimate_DH
HKD1_k127_4083616_9	264462.Bd3447	3.667e-142	468.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,42M84@68525|delta/epsilon subdivisions,2MSZP@213481|Bdellovibrionales,2WJ5V@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	GO:0003674,GO:0003824,GO:0004418,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016740,GO:0016765,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD1_k127_4083616_18	667014.Thein_1683	1.197e-76	267.0	COG0113@1|root,COG0113@2|Bacteria,2GH7X@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	H	Belongs to the ALAD family	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD1_k127_4083616_7	1184267.A11Q_1675	3.881e-180	573.0	COG0001@1|root,COG0001@2|Bacteria,1MUY5@1224|Proteobacteria,42MBF@68525|delta/epsilon subdivisions,2MSUI@213481|Bdellovibrionales,2WJQ2@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	PFAM Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_4083616_23	765869.BDW_12775	7.128e-58	213.0	COG0642@1|root,COG0642@2|Bacteria,1QY2Q@1224|Proteobacteria,43C9Z@68525|delta/epsilon subdivisions,2MUTA@213481|Bdellovibrionales,2X7KF@28221|Deltaproteobacteria	213481|Bdellovibrionales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_4083616_20	264462.Bd3451	1.227e-64	228.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,43AK3@68525|delta/epsilon subdivisions,2MT4V@213481|Bdellovibrionales,2WVKV@28221|Deltaproteobacteria	213481|Bdellovibrionales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4083616_12	1184267.A11Q_1672	2.253e-121	399.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,42MV9@68525|delta/epsilon subdivisions,2MSZ3@213481|Bdellovibrionales,2WJZK@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	GO:0003674,GO:0003824,GO:0004853,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0016830,GO:0016831,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0044424,GO:0044444,GO:0044464,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_0016	URO-D
HKD1_k127_4083616_5	765869.BDW_12790	1.778e-180	574.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,42M87@68525|delta/epsilon subdivisions,2MSM3@213481|Bdellovibrionales,2WMB0@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_4083616_19	264462.Bd3455	1.724e-74	268.0	COG1232@1|root,COG1232@2|Bacteria,1R0KQ@1224|Proteobacteria,42NBG@68525|delta/epsilon subdivisions,2MTXP@213481|Bdellovibrionales,2WKMN@28221|Deltaproteobacteria	213481|Bdellovibrionales	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	hemY	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD1_k127_4083616_15	483219.LILAB_01095	3.36e-101	339.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,42M0C@68525|delta/epsilon subdivisions,2WMJ2@28221|Deltaproteobacteria,2YY0V@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	GO:0003674,GO:0003824,GO:0004325,GO:0006725,GO:0006778,GO:0006779,GO:0006783,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016829,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042168,GO:0042440,GO:0044237,GO:0044249,GO:0044271,GO:0046148,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD1_k127_4083616_14	395494.Galf_1402	6.925e-118	400.0	COG0664@1|root,COG0668@1|root,COG0664@2|Bacteria,COG0668@2|Bacteria,1R6J6@1224|Proteobacteria,2VPCU@28216|Betaproteobacteria,44W84@713636|Nitrosomonadales	28216|Betaproteobacteria	MT	MscS Mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel,cNMP_binding
HKD1_k127_4083616_38	497964.CfE428DRAFT_1207	0.0002643	43.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_4090536_7	555079.Toce_1667	3.706e-18	95.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,2491Y@186801|Clostridia,42F9N@68295|Thermoanaerobacterales	186801|Clostridia	F	5'-nucleotidase	ushA	-	3.1.3.5,3.1.3.6,3.1.4.16,3.6.1.45	ko:K01081,ko:K01119,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01562,R01569,R01664,R01877,R01968,R02088,R02102,R02148,R02323,R02370,R02719,R03346,R03537,R03538,R03929,R05135	RC00017,RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Gram_pos_anchor,LysM,Metallophos,SH3_3
HKD1_k127_4090536_1	592029.DDD_3603	1.316e-83	288.0	COG0737@1|root,COG0737@2|Bacteria,4NESM@976|Bacteroidetes,1HZAE@117743|Flavobacteriia,3HJNV@363408|Nonlabens	976|Bacteroidetes	F	Bacterial capsule synthesis protein PGA_cap	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	Metallophos
HKD1_k127_4090536_4	880073.Calab_3344	8.209e-41	161.0	COG0698@1|root,COG0698@2|Bacteria,2NPF4@2323|unclassified Bacteria	2|Bacteria	G	ribose 5-phosphate isomerase B	upp	-	2.4.2.9,5.3.1.6	ko:K00761,ko:K01808	ko00030,ko00051,ko00240,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00240,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R00966,R01056,R09030	RC00063,RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB,UPRTase
HKD1_k127_4090536_6	661478.OP10G_3744	6.686e-32	133.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4090536_3	1267580.AF6_2689	1.673e-78	273.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,21WRM@150247|Anoxybacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	GO:0003674,GO:0003824,GO:0004139,GO:0005975,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009117,GO:0009166,GO:0009262,GO:0009264,GO:0009987,GO:0016052,GO:0016829,GO:0016830,GO:0016832,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0046434,GO:0046483,GO:0046700,GO:0055086,GO:0071704,GO:1901135,GO:1901136,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	iYO844.BSU39420	DeoC
HKD1_k127_4090536_8	667632.KB890175_gene4120	2.035e-05	53.0	COG3631@1|root,COG3631@2|Bacteria,1RM0Y@1224|Proteobacteria,2VTQT@28216|Betaproteobacteria,1K7GG@119060|Burkholderiaceae	28216|Betaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	ko:K07255	ko00430,map00430	-	R01685	RC00062	ko00000,ko00001,ko01000	-	-	-	SnoaL_2
HKD1_k127_4090536_5	926566.Terro_0661	1.13e-37	154.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HKD1_k127_4090536_2	99598.Cal7507_6086	1.292e-78	266.0	COG3548@1|root,COG3548@2|Bacteria,1GKP7@1117|Cyanobacteria,1HRK3@1161|Nostocales	1117|Cyanobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD1_k127_4090536_0	533240.CRC_00827	4.775e-168	538.0	COG0448@1|root,COG0448@2|Bacteria,1G0IG@1117|Cyanobacteria,1HJRM@1161|Nostocales	1117|Cyanobacteria	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.agp,iSbBS512_1146.agp	NTP_transferase
HKD1_k127_4096247_5	290317.Cpha266_0257	4.063e-139	449.0	COG4974@1|root,COG4974@2|Bacteria,1FESB@1090|Chlorobi	1090|Chlorobi	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_4096247_7	263820.PTO0135	2.651e-86	327.0	COG0515@1|root,arCOG03682@2157|Archaea,2XWZP@28890|Euryarchaeota	28890|Euryarchaeota	T	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NosD,Pkinase
HKD1_k127_4096247_18	1121296.JONJ01000001_gene1632	5.117e-32	147.0	COG4166@1|root,COG4166@2|Bacteria,1VRU1@1239|Firmicutes,255ES@186801|Clostridia,220QH@1506553|Lachnoclostridium	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_4096247_15	1267534.KB906754_gene3732	7.167e-50	181.0	2DTV5@1|root,33MT0@2|Bacteria,3Y5UW@57723|Acidobacteria,2JNBS@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_19	1270193.JARP01000006_gene1754	1.014e-13	78.0	2EBVV@1|root,3003I@2|Bacteria,4PGVY@976|Bacteroidetes,1IG38@117743|Flavobacteriia,2NWI2@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_6	518766.Rmar_1802	6.726e-91	308.0	COG1834@1|root,COG1834@2|Bacteria,4PECN@976|Bacteroidetes,1FIVN@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD1_k127_4096247_3	1343739.PAP_07605	4.727e-182	581.0	COG2403@1|root,arCOG01229@2157|Archaea,2XVYH@28890|Euryarchaeota,24343@183968|Thermococci	183968|Thermococci	S	CobW/HypB/UreG, nucleotide-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cobW
HKD1_k127_4096247_10	204669.Acid345_1083	1.966e-73	250.0	COG2318@1|root,COG2318@2|Bacteria,3Y8H7@57723|Acidobacteria	57723|Acidobacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD1_k127_4096247_8	391625.PPSIR1_11110	2.988e-81	285.0	COG2988@1|root,COG2988@2|Bacteria	2|Bacteria	E	succinylglutamate desuccinylase activity	astE	-	3.5.1.96	ko:K05526	ko00330,ko01100,map00330,map01100	-	R00411	RC00064,RC00090	ko00000,ko00001,ko01000	-	-	-	AstE_AspA
HKD1_k127_4096247_16	1128421.JAGA01000002_gene1382	6.849e-49	178.0	COG2905@1|root,COG2905@2|Bacteria	2|Bacteria	T	signal-transduction protein containing cAMP-binding and CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_4096247_22	246200.SPOA0321	2.216e-06	54.0	COG0346@1|root,COG0346@2|Bacteria,1RIN7@1224|Proteobacteria,2UADI@28211|Alphaproteobacteria,4NCCT@97050|Ruegeria	28211|Alphaproteobacteria	C	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD1_k127_4096247_14	365046.Rta_22780	2.666e-51	184.0	2C6PE@1|root,333XY@2|Bacteria,1R3CF@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_9	1157637.KB892111_gene4201	9.783e-79	272.0	COG2267@1|root,COG2267@2|Bacteria,2GU81@201174|Actinobacteria	201174|Actinobacteria	I	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_0	379066.GAU_2966	0.0	1044.0	28JBD@1|root,2Z964@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_2	379066.GAU_2967	1.746e-266	863.0	2DB7D@1|root,2Z7KR@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_1	1267534.KB906760_gene1562	7.025e-274	865.0	COG3604@1|root,COG3829@1|root,COG3604@2|Bacteria,COG3829@2|Bacteria,3Y2V9@57723|Acidobacteria	57723|Acidobacteria	T	Sigma-54 interaction domain	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS_9,Sigma54_activat
HKD1_k127_4096247_17	1173026.Glo7428_2073	2.973e-48	184.0	COG2931@1|root,COG2931@2|Bacteria,1GB2M@1117|Cyanobacteria	1117|Cyanobacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_20	1267534.KB906760_gene1563	9.105e-12	68.0	29A7N@1|root,2ZX8K@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4096247_4	1254432.SCE1572_41005	4.969e-148	520.0	COG2706@1|root,COG3391@1|root,COG2706@2|Bacteria,COG3391@2|Bacteria,1RB92@1224|Proteobacteria,43CMY@68525|delta/epsilon subdivisions,2X7V4@28221|Deltaproteobacteria,2YXBK@29|Myxococcales	28221|Deltaproteobacteria	G	Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella	-	-	-	-	-	-	-	-	-	-	-	-	VCBS
HKD1_k127_4096247_21	1121904.ARBP01000025_gene6085	5.078e-11	78.0	COG2273@1|root,COG2730@1|root,COG3291@1|root,COG4733@1|root,COG5184@1|root,COG5492@1|root,COG2273@2|Bacteria,COG2730@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	chiA	-	3.2.1.4,3.2.1.73,3.2.1.80	ko:K01179,ko:K01216,ko:K03332,ko:K20276	ko00051,ko00500,ko01100,ko02024,map00051,map00500,map01100,map02024	-	R00879,R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Big_2,CBM_6,CHU_C,F5_F8_type_C,Glyco_hydro_16,PKD
HKD1_k127_4096247_23	765913.ThidrDRAFT_3930	0.0001866	56.0	COG2340@1|root,COG2373@1|root,COG2931@1|root,COG4547@1|root,COG4625@1|root,COG5492@1|root,COG2340@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG4547@2|Bacteria,COG4625@2|Bacteria,COG5492@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
HKD1_k127_4096247_13	485913.Krac_10224	1.816e-59	211.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4096247_11	485913.Krac_10225	1.079e-70	249.0	COG5662@1|root,COG5662@2|Bacteria	2|Bacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_4096247_12	485913.Krac_10224	2.425e-62	219.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4117471_6	1254432.SCE1572_07800	1.085e-45	188.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YZ6I@29|Myxococcales	28221|Deltaproteobacteria	KLT	Serine Threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_4117471_4	234267.Acid_7851	3.907e-54	215.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4117471_8	234267.Acid_1618	3.444e-24	113.0	COG4916@1|root,COG4916@2|Bacteria	2|Bacteria	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD1_k127_4117471_7	443144.GM21_3057	3.12e-37	151.0	COG2340@1|root,COG2340@2|Bacteria,1N566@1224|Proteobacteria,42UZI@68525|delta/epsilon subdivisions,2WR1P@28221|Deltaproteobacteria,43UVM@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Cysteine-rich secretory protein family	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD1_k127_4117471_0	204669.Acid345_1065	2.172e-157	530.0	COG0744@1|root,COG0744@2|Bacteria,3Y42I@57723|Acidobacteria,2JI7Q@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_4117471_5	1407650.BAUB01000001_gene27	2.345e-49	188.0	2DPQC@1|root,332YT@2|Bacteria,1GF5K@1117|Cyanobacteria,1H2V6@1129|Synechococcus	1117|Cyanobacteria	S	Histone deacetylation protein Rxt3	-	-	-	-	-	-	-	-	-	-	-	-	LCCL
HKD1_k127_4117471_1	234267.Acid_0265	3.598e-138	466.0	COG3292@1|root,COG3292@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF1906,VCBS
HKD1_k127_4117471_2	479434.Sthe_0801	5.286e-107	357.0	COG0476@1|root,COG0476@2|Bacteria,2G5Q1@200795|Chloroflexi,27XM2@189775|Thermomicrobia	189775|Thermomicrobia	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD1_k127_4117471_3	237368.SCABRO_03813	1.311e-84	297.0	COG0169@1|root,COG0710@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,2IXKU@203682|Planctomycetes	203682|Planctomycetes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroD	-	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
HKD1_k127_4129280_0	357808.RoseRS_4025	4.17e-126	442.0	COG2319@1|root,COG2319@2|Bacteria,2G86V@200795|Chloroflexi,374S2@32061|Chloroflexia	32061|Chloroflexia	KLT	WD-40 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,WD40
HKD1_k127_4129280_1	118173.KB235914_gene1463	4.682e-14	86.0	COG2931@1|root,COG3391@1|root,COG2931@2|Bacteria,COG3391@2|Bacteria,1G0EB@1117|Cyanobacteria,1H803@1150|Oscillatoriales	1117|Cyanobacteria	G	PFAM Na-Ca exchanger integrin-beta4 peptidase-like FG-GAP	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Calx-beta,DUF4347,He_PIG,HemolysinCabind,PPC,TIG,VCBS
HKD1_k127_4197370_2	1382356.JQMP01000003_gene2203	3.283e-64	227.0	COG1171@1|root,COG1171@2|Bacteria,2G5YN@200795|Chloroflexi,27XYI@189775|Thermomicrobia	189775|Thermomicrobia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4197370_3	483219.LILAB_36415	1.653e-35	154.0	COG3852@1|root,COG3852@2|Bacteria,1NTTH@1224|Proteobacteria,42MC9@68525|delta/epsilon subdivisions,2WIYS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	PFAM ATP-binding region, ATPase domain protein	gnfL	-	2.7.13.3	ko:K02668,ko:K07708,ko:K07709	ko02020,map02020	M00497,M00499,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8
HKD1_k127_4197370_0	667014.Thein_1717	8.78e-191	629.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,2GHDG@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD1_k127_4197370_1	1382359.JIAL01000001_gene1276	1.088e-77	269.0	COG0774@1|root,COG0774@2|Bacteria,3Y40I@57723|Acidobacteria,2JI1R@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis	lpxC	-	3.5.1.108	ko:K02535	ko00540,ko01100,map00540,map01100	M00060	R04587	RC00166,RC00300	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	LpxC
HKD1_k127_4197370_4	935836.JAEL01000201_gene4586	9.454e-07	51.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4197370_5	1499684.CCNP01000012_gene274	0.0003504	44.0	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia,36DDY@31979|Clostridiaceae	186801|Clostridia	O	peptidylprolyl isomerase	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
HKD1_k127_4238413_0	243231.GSU3380	4.197e-165	532.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,42M31@68525|delta/epsilon subdivisions,2WJK4@28221|Deltaproteobacteria	28221|Deltaproteobacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_4238413_3	1198114.AciX9_2795	4.159e-28	131.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria,2JIT1@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_4238413_4	187303.BN69_3282	9.455e-06	53.0	2DRG5@1|root,33BKC@2|Bacteria,1NHF2@1224|Proteobacteria,2UNDF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4383
HKD1_k127_4238413_1	1267535.KB906767_gene3137	1.682e-118	409.0	COG4206@1|root,COG4206@2|Bacteria	2|Bacteria	H	cobalamin-transporting ATPase activity	btuB	-	-	ko:K02014,ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14,1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD1_k127_4238413_2	997346.HMPREF9374_3133	7.074e-47	176.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,4HA28@91061|Bacilli,27BR5@186824|Thermoactinomycetaceae	91061|Bacilli	HP	ATPases associated with a variety of cellular activities	fepC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD1_k127_4299683_2	1121403.AUCV01000021_gene3591	7.591e-92	311.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2MMVI@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Vault protein inter-alpha-trypsin domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HKD1_k127_4299683_5	316067.Geob_3648	4.113e-28	128.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria	2|Bacteria	M	Sugar transferase	epsL	-	-	ko:K19428	-	-	-	-	ko00000,ko01000	-	-	-	Bac_transf
HKD1_k127_4299683_0	204669.Acid345_1052	2.55e-165	550.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_4299683_1	1267534.KB906760_gene1549	6.96e-165	551.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_4299683_4	215803.DB30_3805	8.39e-59	222.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,42MKS@68525|delta/epsilon subdivisions,2WKIH@28221|Deltaproteobacteria,2YXUC@29|Myxococcales	28221|Deltaproteobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_4299683_3	518766.Rmar_2391	1.91e-83	281.0	COG5434@1|root,COG5434@2|Bacteria,4NEM8@976|Bacteroidetes	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28,Glyco_hydro_88,Pectate_lyase_3
HKD1_k127_4305417_1	1136417.AZWE01000006_gene4258	3.603e-122	416.0	COG1032@1|root,COG1032@2|Bacteria,2HGPR@201174|Actinobacteria,4D9TA@85008|Micromonosporales	201174|Actinobacteria	C	Elongator protein 3, MiaB family, Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_4305417_0	1242864.D187_008204	1.282e-293	935.0	2C4IS@1|root,2Z81U@2|Bacteria,1MWZ8@1224|Proteobacteria	1224|Proteobacteria	S	Lantibiotic biosynthesis dehydratase C-term	-	-	-	ko:K20483	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001	-	-	-	Lant_dehydr_C,Lant_dehydr_N
HKD1_k127_4305417_2	1265502.KB905965_gene1356	2.005e-13	78.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2VIAA@28216|Betaproteobacteria,4A9JV@80864|Comamonadaceae	28216|Betaproteobacteria	M	HlyD membrane-fusion protein of T1SS	-	-	-	ko:K02022,ko:K11003	ko03070,ko05133,map03070,map05133	M00325,M00575	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	8.A.1.3.1,8.A.1.3.2	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD1_k127_4327129_6	1396141.BATP01000007_gene5554	8.662e-15	78.0	COG1943@1|root,COG1943@2|Bacteria,46VP6@74201|Verrucomicrobia,2IVSQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_4327129_3	1068980.ARVW01000001_gene5702	1.427e-105	359.0	COG1228@1|root,COG1228@2|Bacteria,2I98N@201174|Actinobacteria,4E1HT@85010|Pseudonocardiales	201174|Actinobacteria	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_4327129_2	452637.Oter_4270	7.654e-186	593.0	COG4225@1|root,COG5434@1|root,COG4225@2|Bacteria,COG5434@2|Bacteria,46V95@74201|Verrucomicrobia,3K7RU@414999|Opitutae	414999|Opitutae	G	Belongs to the glycosyl hydrolase 28 family	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_28,Glyco_hydro_88
HKD1_k127_4327129_1	1198114.AciX9_1369	5.32e-278	869.0	COG5276@1|root,COG5276@2|Bacteria,3Y393@57723|Acidobacteria,2JMHD@204432|Acidobacteriia	2|Bacteria	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HKD1_k127_4327129_5	1198114.AciX9_1370	1.428e-71	250.0	COG3544@1|root,COG3544@2|Bacteria,3Y4G7@57723|Acidobacteria,2JKAH@204432|Acidobacteriia	2|Bacteria	P	Domain of unknown function (DUF305)	-	-	-	-	-	-	-	-	-	-	-	-	DUF305
HKD1_k127_4327129_4	93220.LV28_03815	4.777e-84	292.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2WFNZ@28216|Betaproteobacteria,1KI4E@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	OCD_Mu_crystall
HKD1_k127_4327129_0	204669.Acid345_1624	0.0	1371.0	COG4447@1|root,COG4447@2|Bacteria,3Y2SN@57723|Acidobacteria,2JIF7@204432|Acidobacteriia	204432|Acidobacteriia	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_437294_3	5911.EAR82286	9.601e-33	141.0	COG3914@1|root,KOG4308@1|root,KOG4308@2759|Eukaryota,KOG4626@2759|Eukaryota,3ZDCY@5878|Ciliophora	5878|Ciliophora	GOT	TPR Domain containing protein	-	-	-	ko:K12600	ko03018,map03018	M00392	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_437294_4	240015.ACP_2017	1.605e-25	114.0	COG0789@1|root,COG0789@2|Bacteria,3Y56I@57723|Acidobacteria,2JJNQ@204432|Acidobacteriia	204432|Acidobacteriia	K	Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_437294_0	1267533.KB906734_gene3660	5.378e-152	489.0	COG0436@1|root,COG0436@2|Bacteria,3Y64P@57723|Acidobacteria,2JMB5@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_437294_1	204669.Acid345_4694	4.623e-72	256.0	COG0611@1|root,COG0611@2|Bacteria,3Y30U@57723|Acidobacteria,2JHT0@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_437294_5	1121396.KB893065_gene1611	1.33e-12	79.0	COG1470@1|root,COG2885@1|root,COG1470@2|Bacteria,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	3.2.1.18	ko:K01186,ko:K02487,ko:K12543	ko00511,ko00600,ko02020,ko04142,map00511,map00600,map02020,map04142	M00330,M00507	R04018	RC00028,RC00077	ko00000,ko00001,ko00002,ko01000,ko02000,ko02022,ko02035,ko02042,ko02044	1.B.17,3.A.1.109.4	GH33	-	BNR_2,DUF11,NPCBM_assoc,OEP,OmpA,TSP_3
HKD1_k127_437294_2	204669.Acid345_3992	5.204e-67	234.0	COG0215@1|root,COG0215@2|Bacteria,3Y2PW@57723|Acidobacteria,2JHIQ@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD1_k127_4375318_16	1123393.KB891316_gene1372	2.954e-71	253.0	COG0726@1|root,COG0726@2|Bacteria,1RFCG@1224|Proteobacteria,2VX6Q@28216|Betaproteobacteria	28216|Betaproteobacteria	G	polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_4375318_3	1123065.ATWL01000002_gene1444	1.251e-193	618.0	COG1874@1|root,COG1874@2|Bacteria,2IE1F@201174|Actinobacteria	201174|Actinobacteria	G	Beta-galactosidase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4978,Glyco_hydro_35,Glyco_hydro_42,RicinB_lectin_2
HKD1_k127_4375318_0	1340493.JNIF01000003_gene2760	1.399e-277	894.0	COG2067@1|root,COG2067@2|Bacteria,3Y41G@57723|Acidobacteria	57723|Acidobacteria	I	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_4375318_5	234267.Acid_2678	1.423e-120	399.0	COG1940@1|root,COG1940@2|Bacteria,3Y3B2@57723|Acidobacteria	57723|Acidobacteria	GK	PFAM ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
HKD1_k127_4375318_12	1123393.KB891316_gene2022	2.249e-78	268.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2VKZ6@28216|Betaproteobacteria,1KSEH@119069|Hydrogenophilales	119069|Hydrogenophilales	O	Peptide methionine sulfoxide reductase	-	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD1_k127_4375318_18	1267533.KB906735_gene4979	5.13e-66	239.0	COG4270@1|root,COG4270@2|Bacteria,3Y5DS@57723|Acidobacteria	57723|Acidobacteria	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4375318_33	240015.ACP_1268	1.284e-20	95.0	2CDRA@1|root,2Z7QN@2|Bacteria,3Y73N@57723|Acidobacteria,2JMK6@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4375318_26	234267.Acid_3644	1.102e-39	151.0	COG3534@1|root,COG3534@2|Bacteria,3Y4TC@57723|Acidobacteria	57723|Acidobacteria	G	Alpha-L-arabinofuranosidase C-terminal domain	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HKD1_k127_4375318_23	1046714.AMRX01000003_gene432	4.888e-53	207.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,1T1IW@1236|Gammaproteobacteria,464PS@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	COG2204 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	fleQ	-	-	ko:K10941	ko02020,ko02025,ko05111,map02020,map02025,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	FleQ,HTH_8,Sigma54_activat
HKD1_k127_4375318_30	99598.Cal7507_2276	9.087e-34	134.0	COG4551@1|root,COG4551@2|Bacteria,1G8WX@1117|Cyanobacteria,1HP03@1161|Nostocales	1117|Cyanobacteria	S	PFAM Low molecular weight phosphotyrosine protein phosphatase	-	-	-	-	-	-	-	-	-	-	-	-	LMWPc
HKD1_k127_4375318_9	448385.sce3630	6.855e-92	319.0	COG2319@1|root,COG2909@1|root,COG2319@2|Bacteria,COG2909@2|Bacteria,1MWJA@1224|Proteobacteria,4348M@68525|delta/epsilon subdivisions,2X2KK@28221|Deltaproteobacteria,2YY8M@29|Myxococcales	28221|Deltaproteobacteria	K	NACHT domain	-	-	-	-	-	-	-	-	-	-	-	-	WD40
HKD1_k127_4375318_21	768670.Calni_0847	3.152e-58	231.0	COG2319@1|root,COG4249@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,2GG9I@200930|Deferribacteres	200930|Deferribacteres	G	peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HKD1_k127_4375318_27	8081.XP_008430865.1	8.095e-39	165.0	COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3BFJC@33208|Metazoa,3CU3G@33213|Bilateria,487NG@7711|Chordata,49AM8@7742|Vertebrata,49QII@7898|Actinopterygii	33208|Metazoa	S	Ankyrin repeat domain-containing protein 50-like	ankrd50	-	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	AAA_16,Ank_2,Ank_4
HKD1_k127_4375318_39	1137269.AZWL01000013_gene2723	1.571e-09	71.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria	1137269.AZWL01000013_gene2723|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4375318_4	760192.Halhy_2265	3.728e-133	454.0	COG2319@1|root,COG2319@2|Bacteria,4NKC3@976|Bacteroidetes,1J18Y@117747|Sphingobacteriia	976|Bacteroidetes	C	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HKD1_k127_4375318_11	1170562.Cal6303_2739	8.011e-79	291.0	COG0520@1|root,COG1672@1|root,COG2319@1|root,COG0520@2|Bacteria,COG1672@2|Bacteria,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria,1HINJ@1161|Nostocales	1117|Cyanobacteria	L	PFAM WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,WD40
HKD1_k127_4375318_20	1170562.Cal6303_1366	2.448e-60	238.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria	1117|Cyanobacteria	A	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35,WD40
HKD1_k127_4375318_13	5786.XP_003287080.1	5.055e-77	286.0	COG2319@1|root,KOG0271@1|root,KOG4155@1|root,KOG0271@2759|Eukaryota,KOG3602@2759|Eukaryota,KOG4155@2759|Eukaryota,3XBNG@554915|Amoebozoa	554915|Amoebozoa	S	TROVE domain	-	-	-	ko:K11127	-	-	-	-	ko00000,ko03032	-	-	-	DUF4062,TROVE,WD40
HKD1_k127_4375318_36	428125.CLOLEP_00542	1.209e-15	89.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,3WGYI@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the ClpA ClpB family	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD1_k127_4375318_19	1499967.BAYZ01000184_gene4591	1.918e-61	231.0	COG0638@1|root,COG0638@2|Bacteria,2NQFW@2323|unclassified Bacteria	2|Bacteria	O	Pup-ligase protein	pafA	GO:0000166,GO:0000302,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006464,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008144,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0016020,GO:0016740,GO:0016874,GO:0016879,GO:0016881,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019787,GO:0019941,GO:0030163,GO:0030312,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034599,GO:0034614,GO:0035639,GO:0035690,GO:0036094,GO:0036211,GO:0042221,GO:0042493,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044464,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070490,GO:0070647,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097159,GO:0097366,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170	6.3.1.19	ko:K13571	-	M00342	R11207	RC00090,RC00096	ko00000,ko00002,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_4375318_17	671143.DAMO_0750	5.095e-68	253.0	COG4122@1|root,COG4122@2|Bacteria,2NQFB@2323|unclassified Bacteria	2|Bacteria	S	Pup-ligase protein	dop	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006464,GO:0006508,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008233,GO:0009056,GO:0009057,GO:0009987,GO:0010498,GO:0016787,GO:0016810,GO:0016811,GO:0017076,GO:0018193,GO:0018205,GO:0019538,GO:0019941,GO:0030163,GO:0030554,GO:0032446,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0036211,GO:0043167,GO:0043168,GO:0043170,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0051603,GO:0070490,GO:0070647,GO:0071704,GO:0097159,GO:0097367,GO:0140096,GO:1901265,GO:1901363,GO:1901564,GO:1901565,GO:1901575	3.5.1.119	ko:K20814	-	-	-	-	ko00000,ko01000,ko03051	-	-	-	Pup_ligase
HKD1_k127_4375318_15	469371.Tbis_1838	7.306e-73	267.0	COG1222@1|root,COG1222@2|Bacteria,2GMR1@201174|Actinobacteria,4DZ1H@85010|Pseudonocardiales	201174|Actinobacteria	O	ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis	arc	GO:0000302,GO:0000502,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005886,GO:0006508,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009405,GO:0009987,GO:0010035,GO:0010498,GO:0010499,GO:0016020,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019538,GO:0019941,GO:0022623,GO:0022624,GO:0030163,GO:0030312,GO:0032991,GO:0033554,GO:0034599,GO:0034614,GO:0035690,GO:0042221,GO:0042493,GO:0042802,GO:0043170,GO:0043335,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044419,GO:0044424,GO:0044464,GO:0044877,GO:0050896,GO:0051409,GO:0051603,GO:0051704,GO:0051716,GO:0070628,GO:0070887,GO:0071241,GO:0071704,GO:0071731,GO:0071732,GO:0071944,GO:0097366,GO:0140030,GO:0140035,GO:1901564,GO:1901565,GO:1901575,GO:1901698,GO:1901699,GO:1901700,GO:1901701,GO:1902170,GO:1902494,GO:1905368,GO:1905369	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA,Prot_ATP_ID_OB
HKD1_k127_4375318_37	575540.Isop_1343	5.475e-11	74.0	COG1310@1|root,COG1310@2|Bacteria,2IZZW@203682|Planctomycetes	203682|Planctomycetes	M	PFAM Mov34 MPN PAD-1 family	-	-	-	-	-	-	-	-	-	-	-	-	JAB
HKD1_k127_4375318_44	388467.A19Y_2738	1.295e-06	59.0	COG5078@1|root,COG5078@2|Bacteria,1GDKY@1117|Cyanobacteria,1HFCY@1150|Oscillatoriales	1117|Cyanobacteria	O	Ubiquitin-conjugating enzyme E2, catalytic domain homologues	-	-	-	-	-	-	-	-	-	-	-	-	UQ_con
HKD1_k127_4375318_32	1278073.MYSTI_05406	2.565e-29	133.0	COG0476@1|root,COG0476@2|Bacteria	2|Bacteria	H	Involved in molybdopterin and thiamine biosynthesis, family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD1_k127_4375318_31	1386089.N865_20490	3.707e-32	134.0	COG0758@1|root,COG0758@2|Bacteria	2|Bacteria	LU	DNA mediated transformation	smf	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_4375318_1	324925.Ppha_1462	2.811e-228	737.0	COG0464@1|root,COG0464@2|Bacteria	2|Bacteria	O	ATPase activity	-	-	-	ko:K13527	ko03050,map03050	M00342	-	-	ko00000,ko00001,ko00002,ko03051	-	-	-	AAA
HKD1_k127_4375318_42	204669.Acid345_4390	1.268e-06	55.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_4375318_7	211165.AJLN01000050_gene5267	1.151e-113	383.0	COG1167@1|root,COG1167@2|Bacteria,1G2H6@1117|Cyanobacteria,1JJP3@1189|Stigonemataceae	1117|Cyanobacteria	EK	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD1_k127_4375318_22	1123020.AUIE01000016_gene1980	1.267e-54	192.0	COG5470@1|root,COG5470@2|Bacteria,1RIH6@1224|Proteobacteria,1S63X@1236|Gammaproteobacteria,1YGDK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HKD1_k127_4375318_25	324057.Pjdr2_0668	2.015e-47	173.0	COG0607@1|root,COG0607@2|Bacteria,1VYAE@1239|Firmicutes,4HXM9@91061|Bacilli,275RR@186822|Paenibacillaceae	91061|Bacilli	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_4375318_14	861299.J421_6133	2.997e-74	259.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	dcsG	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,RimK
HKD1_k127_4375318_8	1267535.KB906767_gene632	1.533e-107	355.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4375318_35	1232410.KI421412_gene337	7.227e-19	89.0	2C59E@1|root,2ZDAY@2|Bacteria	2|Bacteria	S	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_4375318_34	1232410.KI421412_gene336	5.189e-20	91.0	29SGJ@1|root,2ZKKB@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4375318_45	1121289.JHVL01000038_gene2998	0.0008026	49.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	prdR	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_4375318_10	65393.PCC7424_0708	6.421e-87	297.0	COG0384@1|root,COG0384@2|Bacteria,1G0Y0@1117|Cyanobacteria,3KHGC@43988|Cyanothece	1117|Cyanobacteria	S	PFAM Phenazine biosynthesis PhzC PhzF protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_4375318_24	1405.DJ92_3414	9.136e-48	183.0	COG0491@1|root,COG0491@2|Bacteria,1U974@1239|Firmicutes,4IJ9B@91061|Bacilli,1ZN0N@1386|Bacillus	91061|Bacilli	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_4375318_2	861299.J421_5758	8.773e-216	697.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_4375318_6	706587.Desti_3024	3.513e-114	377.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,43DPM@68525|delta/epsilon subdivisions,2X9UC@28221|Deltaproteobacteria,2MS8D@213462|Syntrophobacterales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_4375318_43	62928.azo3635	1.271e-06	57.0	COG0454@1|root,COG0456@2|Bacteria,1N506@1224|Proteobacteria,2VUQX@28216|Betaproteobacteria	28216|Betaproteobacteria	K	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_4375318_38	580340.Tlie_0020	2.799e-10	64.0	COG1794@1|root,COG1794@2|Bacteria,3TBD3@508458|Synergistetes	508458|Synergistetes	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HKD1_k127_4375318_28	1121878.AUGL01000001_gene356	2.321e-38	148.0	COG0662@1|root,COG0662@2|Bacteria,1N3N8@1224|Proteobacteria,1SCAS@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_4375318_40	224911.27349666	1.718e-08	57.0	COG0640@1|root,COG0640@2|Bacteria,1N8QA@1224|Proteobacteria,2UC02@28211|Alphaproteobacteria,3JZ6B@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	ybzH	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_4413371_41	204669.Acid345_3993	1.929e-31	139.0	COG2304@1|root,COG2304@2|Bacteria,3Y44P@57723|Acidobacteria,2JIT1@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_4413371_5	886293.Sinac_6154	1.039e-173	575.0	COG2866@1|root,COG2866@2|Bacteria,2IXPH@203682|Planctomycetes	203682|Planctomycetes	E	PFAM Zinc carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD1_k127_4413371_38	1223543.GP2_030_00070	6.257e-38	154.0	COG0204@1|root,COG0560@1|root,COG0204@2|Bacteria,COG0560@2|Bacteria,2GJVX@201174|Actinobacteria,4GBAY@85026|Gordoniaceae	201174|Actinobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51,3.1.3.3	ko:K15781	-	-	-	-	ko00000,ko01000	-	-	-	Acyltransferase,HAD
HKD1_k127_4413371_29	234267.Acid_5311	1.333e-51	198.0	28M4B@1|root,2ZAI9@2|Bacteria,3Y3NA@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4413371_2	204669.Acid345_2022	0.0	1164.0	COG0178@1|root,COG0178@2|Bacteria,3Y3PA@57723|Acidobacteria,2JISM@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	-	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_4413371_22	449447.MAE_55810	6.404e-68	241.0	COG0515@1|root,COG1262@1|root,COG0515@2|Bacteria,COG1262@2|Bacteria,1FZWQ@1117|Cyanobacteria	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,Pkinase
HKD1_k127_4413371_32	221288.JH992901_gene754	5.256e-46	179.0	COG1262@1|root,COG1262@2|Bacteria,1G0ZT@1117|Cyanobacteria,1JJKE@1189|Stigonemataceae	1117|Cyanobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_4413371_46	1157638.KB892180_gene3995	1.853e-15	91.0	COG0526@1|root,COG0526@2|Bacteria,2IJEI@201174|Actinobacteria	201174|Actinobacteria	CO	Glutathione peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_4413371_37	2074.JNYD01000008_gene1228	1.316e-40	174.0	COG0443@1|root,COG3391@1|root,COG4995@1|root,COG0443@2|Bacteria,COG3391@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,HSP70
HKD1_k127_4413371_17	383372.Rcas_2288	8.559e-85	314.0	COG0515@1|root,COG0515@2|Bacteria,2GACY@200795|Chloroflexi,375GK@32061|Chloroflexia	32061|Chloroflexia	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_4413371_40	1158318.ATXC01000001_gene854	7.099e-33	132.0	COG1610@1|root,COG1610@2|Bacteria,2G4V2@200783|Aquificae	200783|Aquificae	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_4413371_25	1121468.AUBR01000016_gene2299	7.72e-59	220.0	COG1565@1|root,COG1565@2|Bacteria,1V2II@1239|Firmicutes,24GK7@186801|Clostridia,42I8X@68295|Thermoanaerobacterales	186801|Clostridia	S	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD1_k127_4413371_34	234267.Acid_0097	2.274e-42	158.0	COG3682@1|root,COG3682@2|Bacteria,3Y57R@57723|Acidobacteria	57723|Acidobacteria	K	Transcriptional repressor, CopY family	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD1_k127_4413371_39	234267.Acid_0096	2.572e-35	156.0	COG4219@1|root,COG4219@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56,TonB_C
HKD1_k127_4413371_47	1267535.KB906767_gene9	2.61e-10	74.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD1_k127_4413371_50	9818.XP_007935060.1	0.0004293	46.0	2FCKK@1|root,2TDVH@2759|Eukaryota,3A9T3@33154|Opisthokonta,3BUSF@33208|Metazoa,3D99F@33213|Bilateria,48FZX@7711|Chordata,49CXW@7742|Vertebrata,3JI0F@40674|Mammalia,357TJ@311790|Afrotheria	33208|Metazoa	S	Proline-rich acidic protein 1	PRAP1	GO:0000981,GO:0003674,GO:0003700,GO:0006355,GO:0006357,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0140110,GO:1903506,GO:2000112,GO:2001141	-	ko:K21250	ko04140,map04140	-	-	-	ko00000,ko00001	-	-	-	PRAP
HKD1_k127_4413371_49	745310.G432_11155	4.989e-05	57.0	COG0810@1|root,COG0810@2|Bacteria,1MZPX@1224|Proteobacteria,2UHNB@28211|Alphaproteobacteria,2K4Y8@204457|Sphingomonadales	204457|Sphingomonadales	M	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins	tonB_2	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_4413371_3	234267.Acid_0759	0.0	1069.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2920,Peptidase_S9
HKD1_k127_4413371_15	251221.35214601	1.802e-96	333.0	COG0845@1|root,COG0845@2|Bacteria,1G49W@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K07799	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_4413371_0	1173023.KE650771_gene3661	0.0	1214.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria,1JIE7@1189|Stigonemataceae	1117|Cyanobacteria	V	MMPL family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4413371_1	251221.35214602	0.0	1210.0	COG0841@1|root,COG0841@2|Bacteria,1G0C2@1117|Cyanobacteria	1117|Cyanobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296	-	-	-	-	ko00000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4413371_28	682795.AciX8_4568	2.042e-52	200.0	COG1463@1|root,COG1463@2|Bacteria,3Y3SX@57723|Acidobacteria,2JIP6@204432|Acidobacteriia	204432|Acidobacteriia	Q	MlaD protein	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD1_k127_4413371_23	401053.AciPR4_1852	1.066e-67	244.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria,2JIF1@204432|Acidobacteriia	204432|Acidobacteriia	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_4413371_21	1382359.JIAL01000001_gene2412	2.25e-68	240.0	COG0767@1|root,COG0767@2|Bacteria,3Y43S@57723|Acidobacteria,2JI8E@204432|Acidobacteriia	204432|Acidobacteriia	Q	Belongs to the MlaE permease family	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD1_k127_4413371_42	1298863.AUEP01000006_gene3474	1.91e-29	126.0	COG1595@1|root,COG1595@2|Bacteria,2GJMX@201174|Actinobacteria,4DQKT@85009|Propionibacteriales	201174|Actinobacteria	K	ECF sigma factor	sigM	GO:0001101,GO:0005575,GO:0005623,GO:0005886,GO:0006355,GO:0008150,GO:0009410,GO:0009415,GO:0009628,GO:0009889,GO:0009891,GO:0009893,GO:0010035,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0016020,GO:0019219,GO:0019222,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0042221,GO:0044464,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0060255,GO:0065007,GO:0071944,GO:0080090,GO:1901700,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4413371_14	204669.Acid345_3335	5.549e-101	352.0	COG2206@1|root,COG5000@1|root,COG2206@2|Bacteria,COG5000@2|Bacteria,3Y7I5@57723|Acidobacteria,2JMTE@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_4413371_13	1267535.KB906767_gene4183	6.877e-102	344.0	COG0552@1|root,COG0552@2|Bacteria,3Y3JQ@57723|Acidobacteria,2JIXJ@204432|Acidobacteriia	204432|Acidobacteriia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_4413371_16	264732.Moth_0915	2.052e-96	328.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,42F0T@68295|Thermoanaerobacterales	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD1_k127_4413371_24	1123257.AUFV01000006_gene439	8.115e-61	220.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,1RMHW@1236|Gammaproteobacteria,1X38K@135614|Xanthomonadales	135614|Xanthomonadales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	GO:0000154,GO:0000179,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016433,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_4413371_43	234267.Acid_2001	9.389e-26	110.0	COG2315@1|root,COG2315@2|Bacteria	2|Bacteria	V	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD1_k127_4413371_10	643473.KB235930_gene4348	4.905e-142	465.0	COG2124@1|root,COG2124@2|Bacteria,1G3SX@1117|Cyanobacteria,1HMP2@1161|Nostocales	1117|Cyanobacteria	Q	PFAM cytochrome P450	-	-	-	-	-	-	-	-	-	-	-	-	p450
HKD1_k127_4413371_26	1254432.SCE1572_24085	4.084e-56	199.0	COG0454@1|root,COG0454@2|Bacteria,1QU6C@1224|Proteobacteria	1224|Proteobacteria	K	-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_4413371_11	234267.Acid_7916	3.312e-138	469.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD1_k127_4413371_20	862908.BMS_0873	4.125e-71	248.0	COG3757@1|root,COG3757@2|Bacteria,1R57X@1224|Proteobacteria,42ZY3@68525|delta/epsilon subdivisions,2WVJN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Glycosyl hydrolases family 25	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_25
HKD1_k127_4413371_7	1121472.AQWN01000005_gene2569	2.127e-154	506.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,2601W@186807|Peptococcaceae	186801|Clostridia	J	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD1_k127_4413371_27	1210884.HG799462_gene8069	6.619e-56	206.0	COG0300@1|root,COG0300@2|Bacteria,2J0SJ@203682|Planctomycetes	203682|Planctomycetes	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_4413371_18	1191523.MROS_1733	2.852e-77	267.0	COG1968@1|root,COG1968@2|Bacteria	2|Bacteria	V	undecaprenyl-diphosphatase activity	uppP	GO:0006950,GO:0008150,GO:0050896,GO:0051409	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_4413371_9	204669.Acid345_4172	8.003e-144	475.0	COG0608@1|root,COG0608@2|Bacteria,3Y3HI@57723|Acidobacteria,2JICS@204432|Acidobacteriia	204432|Acidobacteriia	L	single-stranded-DNA-specific exonuclease RecJ	-	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_4413371_35	204669.Acid345_1660	3.136e-42	178.0	COG1452@1|root,COG1452@2|Bacteria	2|Bacteria	M	lipopolysaccharide transport	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC,OstA
HKD1_k127_4413371_4	204669.Acid345_1158	5.517e-180	571.0	COG0133@1|root,COG0133@2|Bacteria,3Y45B@57723|Acidobacteria,2JIVM@204432|Acidobacteriia	204432|Acidobacteriia	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4413371_19	1267535.KB906767_gene284	3.283e-77	266.0	COG0159@1|root,COG0159@2|Bacteria,3Y3X2@57723|Acidobacteria,2JI7C@204432|Acidobacteriia	204432|Acidobacteriia	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD1_k127_4413371_8	1267533.KB906733_gene3429	2.653e-149	480.0	COG0468@1|root,COG0468@2|Bacteria,3Y3Y1@57723|Acidobacteria,2JHU1@204432|Acidobacteriia	204432|Acidobacteriia	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD1_k127_4413371_6	293826.Amet_4572	1.352e-156	507.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36FIQ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_4413371_31	1033810.HLPCO_001451	9.556e-48	183.0	COG1947@1|root,COG1947@2|Bacteria,2NPGM@2323|unclassified Bacteria	2|Bacteria	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0006629,GO:0006720,GO:0006793,GO:0006796,GO:0008144,GO:0008150,GO:0008152,GO:0008299,GO:0008610,GO:0009058,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0017076,GO:0030554,GO:0032553,GO:0032555,GO:0032559,GO:0035639,GO:0036094,GO:0040007,GO:0043167,GO:0043168,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0050515,GO:0071704,GO:0097159,GO:0097367,GO:1901265,GO:1901363,GO:1901576	2.1.1.182,2.7.1.148	ko:K00919,ko:K02528,ko:K16924	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096,M00582	R05634,R10716	RC00002,RC00003,RC01439,RC03257	ko00000,ko00001,ko00002,ko01000,ko02000,ko03009	3.A.1.29	-	iEC55989_1330.EC55989_1304,iLJ478.TM1383,iYO844.BSU00460	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_4413371_48	1399774.JDWH01000007_gene1591	1.963e-05	47.0	2EFWG@1|root,339NR@2|Bacteria,1NIWH@1224|Proteobacteria,1SHRN@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4413371_12	1198114.AciX9_0319	1.211e-120	394.0	COG0462@1|root,COG0462@2|Bacteria,3Y3KV@57723|Acidobacteria,2JHTF@204432|Acidobacteriia	204432|Acidobacteriia	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD1_k127_4413371_33	278963.ATWD01000001_gene3113	1.837e-45	172.0	COG1825@1|root,COG1825@2|Bacteria,3Y41C@57723|Acidobacteria,2JHW5@204432|Acidobacteriia	204432|Acidobacteriia	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD1_k127_4413371_30	867845.KI911784_gene2048	6.918e-51	187.0	COG0193@1|root,COG0193@2|Bacteria,2G6SW@200795|Chloroflexi,375JU@32061|Chloroflexia	32061|Chloroflexia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	GO:0003674,GO:0003824,GO:0004045,GO:0016787,GO:0016788,GO:0052689,GO:0140098,GO:0140101	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD1_k127_4413371_45	639030.JHVA01000001_gene2818	7.69e-22	100.0	COG0360@1|root,COG0360@2|Bacteria,3Y50N@57723|Acidobacteria,2JJHP@204432|Acidobacteriia	204432|Acidobacteriia	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD1_k127_4413371_44	903818.KI912269_gene342	1.59e-24	106.0	COG0238@1|root,COG0238@2|Bacteria,3Y53K@57723|Acidobacteria	57723|Acidobacteria	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD1_k127_4413371_36	278963.ATWD01000001_gene3109	4.854e-41	157.0	COG0359@1|root,COG0359@2|Bacteria,3Y4MD@57723|Acidobacteria,2JJAN@204432|Acidobacteriia	204432|Acidobacteriia	J	binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD1_k127_4413371_51	1198114.AciX9_2677	0.0007549	52.0	COG2304@1|root,COG2304@2|Bacteria,3Y6C6@57723|Acidobacteria,2JKKE@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA
HKD1_k127_4428545_36	204669.Acid345_0559	1.229e-49	193.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,LolA_like,MacB_PCD
HKD1_k127_4428545_25	204669.Acid345_0970	8.081e-78	265.0	COG1136@1|root,COG1136@2|Bacteria,3Y3JD@57723|Acidobacteria,2JIHH@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4428545_7	204669.Acid345_2766	3.519e-142	459.0	COG0535@1|root,COG0535@2|Bacteria,3Y3QA@57723|Acidobacteria,2JIAZ@204432|Acidobacteriia	204432|Acidobacteriia	S	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_4428545_50	1267535.KB906767_gene623	4.801e-24	110.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_4428545_69	204669.Acid345_2506	1.192e-07	57.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_4428545_13	278963.ATWD01000001_gene1477	3.998e-123	410.0	COG0469@1|root,COG0469@2|Bacteria,3Y36V@57723|Acidobacteria,2JHY5@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the pyruvate kinase family	-	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD1_k127_4428545_48	1081640.AGFU01000005_gene1092	2.77e-26	115.0	COG2020@1|root,COG2020@2|Bacteria,1RCWQ@1224|Proteobacteria,2U0I9@28211|Alphaproteobacteria,2K4Z6@204457|Sphingomonadales	204457|Sphingomonadales	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HKD1_k127_4428545_46	204669.Acid345_0181	9.318e-28	119.0	COG0526@1|root,COG0526@2|Bacteria,3Y4K8@57723|Acidobacteria,2JJAP@204432|Acidobacteriia	204432|Acidobacteriia	CO	Glutathione peroxidase	-	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA
HKD1_k127_4428545_57	1122197.ATWI01000008_gene2991	6.34e-17	82.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,1SC7M@1236|Gammaproteobacteria,468WS@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	GO:0003674,GO:0004857,GO:0005488,GO:0008150,GO:0008270,GO:0008657,GO:0010911,GO:0030234,GO:0032780,GO:0042030,GO:0043086,GO:0043167,GO:0043169,GO:0043462,GO:0044092,GO:0046872,GO:0046914,GO:0050790,GO:0051336,GO:0051346,GO:0060589,GO:0060590,GO:0065007,GO:0065009,GO:0072586,GO:0098772,GO:2000371,GO:2000372	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD1_k127_4428545_61	1463845.JOIG01000003_gene5048	2.134e-12	75.0	COG1695@1|root,COG4832@1|root,COG1695@2|Bacteria,COG4832@2|Bacteria,2GN4K@201174|Actinobacteria	201174|Actinobacteria	K	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD1_k127_4428545_45	1121015.N789_04805	1.661e-29	123.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4428545_56	1123399.AQVE01000006_gene3563	1.098e-17	91.0	2DNKW@1|root,32Y18@2|Bacteria,1ND1M@1224|Proteobacteria,1SQBD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_38	880073.Calab_1913	3.716e-46	180.0	COG1994@1|root,COG1994@2|Bacteria,2NP89@2323|unclassified Bacteria	2|Bacteria	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD1_k127_4428545_42	204669.Acid345_1185	3.213e-33	132.0	COG0776@1|root,COG0776@2|Bacteria,3Y4U4@57723|Acidobacteria,2JP27@204432|Acidobacteriia	204432|Acidobacteriia	L	bacterial (prokaryotic) histone like domain	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_4428545_37	1267535.KB906767_gene404	3.204e-47	178.0	COG0681@1|root,COG0681@2|Bacteria,3Y49Z@57723|Acidobacteria,2JJ4I@204432|Acidobacteriia	204432|Acidobacteriia	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_4428545_34	234267.Acid_6464	2.465e-50	196.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_6464|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_24	1122182.KB903834_gene5898	2.049e-86	296.0	COG2013@1|root,COG2013@2|Bacteria,2I9XC@201174|Actinobacteria,4DJFC@85008|Micromonosporales	201174|Actinobacteria	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD1_k127_4428545_10	383372.Rcas_3359	5.021e-133	434.0	COG0505@1|root,COG0505@2|Bacteria,2G5S1@200795|Chloroflexi,3755X@32061|Chloroflexia	32061|Chloroflexia	F	TIGRFAM carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_4428545_41	204669.Acid345_0566	1.955e-35	151.0	COG0628@1|root,COG0628@2|Bacteria,3Y40R@57723|Acidobacteria,2JIX8@204432|Acidobacteriia	204432|Acidobacteriia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_4428545_2	204669.Acid345_3520	9.301e-308	953.0	COG0365@1|root,COG0365@2|Bacteria,3Y39K@57723|Acidobacteria,2JI3Z@204432|Acidobacteriia	204432|Acidobacteriia	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_4428545_26	204669.Acid345_4418	1.208e-76	269.0	2CHAC@1|root,2Z7QK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_18	234267.Acid_2600	7.767e-106	355.0	COG2404@1|root,COG2404@2|Bacteria,3Y98M@57723|Acidobacteria	57723|Acidobacteria	S	hydrolase activity, acting on ester bonds	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_32	204669.Acid345_2869	2.095e-62	224.0	COG0682@1|root,COG0682@2|Bacteria,3Y4HT@57723|Acidobacteria,2JJTI@204432|Acidobacteriia	204432|Acidobacteriia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	-	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_4428545_44	663321.REG_0855	8.624e-31	128.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,1S60E@1236|Gammaproteobacteria,282SS@191675|unclassified Enterobacteriaceae	1236|Gammaproteobacteria	M	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	GO:0003674,GO:0003824,GO:0004175,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0009058,GO:0009059,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0019538,GO:0031224,GO:0031226,GO:0034645,GO:0042157,GO:0042158,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044425,GO:0044459,GO:0044464,GO:0070011,GO:0071704,GO:0071944,GO:0097304,GO:0140096,GO:1901564,GO:1901566,GO:1901576	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD1_k127_4428545_1	1267535.KB906767_gene2620	0.0	1047.0	COG0060@1|root,COG0060@2|Bacteria,3Y3JW@57723|Acidobacteria,2JIQ2@204432|Acidobacteriia	204432|Acidobacteriia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD1_k127_4428545_66	562743.JH976441_gene514	5.132e-08	61.0	COG4980@1|root,COG4980@2|Bacteria	2|Bacteria	D	gas vesicle protein	XK27_07760	-	-	-	-	-	-	-	-	-	-	-	YtxH
HKD1_k127_4428545_30	861299.J421_3649	5.157e-66	234.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_4428545_21	1077144.AGFF01000007_gene1668	1.453e-96	326.0	COG1131@1|root,COG1131@2|Bacteria,2GIY8@201174|Actinobacteria	201174|Actinobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4428545_53	1128427.KB904821_gene3010	9.757e-20	96.0	2DMJE@1|root,32RYR@2|Bacteria,1G6SI@1117|Cyanobacteria,1HBXF@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
HKD1_k127_4428545_40	1128421.JAGA01000004_gene2493	3.455e-45	184.0	COG0308@1|root,COG0308@2|Bacteria,2NPPZ@2323|unclassified Bacteria	2|Bacteria	E	Peptidase family M1 domain	pepN	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD1_k127_4428545_35	1278073.MYSTI_05126	8.904e-50	201.0	COG0652@1|root,COG1413@1|root,COG0652@2|Bacteria,COG1413@2|Bacteria,1R4KH@1224|Proteobacteria,42R08@68525|delta/epsilon subdivisions,2WWSG@28221|Deltaproteobacteria,2YVBS@29|Myxococcales	28221|Deltaproteobacteria	M	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD	-	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	HEAT_2,Pro_isomerase
HKD1_k127_4428545_55	573370.DMR_27510	7.843e-18	91.0	COG1664@1|root,COG1664@2|Bacteria,1N7TF@1224|Proteobacteria,42VWZ@68525|delta/epsilon subdivisions,2WRPF@28221|Deltaproteobacteria,2MBWU@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_4428545_19	1267535.KB906767_gene392	1.157e-101	340.0	COG3643@1|root,COG3643@2|Bacteria,3Y3HP@57723|Acidobacteria,2JIP9@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Formiminotransferase domain	-	-	2.1.2.5,4.3.1.4	ko:K00603,ko:K13990	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R02302,R03189	RC00165,RC00221,RC00223,RC00688,RC00870	ko00000,ko00001,ko01000,ko03036,ko04147	-	-	-	FTCD,FTCD_N
HKD1_k127_4428545_29	357808.RoseRS_3801	2.734e-70	249.0	COG1300@1|root,COG1300@2|Bacteria,2G8HV@200795|Chloroflexi,37546@32061|Chloroflexia	32061|Chloroflexia	S	Stage II sporulation protein M	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIM
HKD1_k127_4428545_28	1297742.A176_02720	4.521e-71	257.0	COG1721@1|root,COG1721@2|Bacteria,1MXDI@1224|Proteobacteria	1224|Proteobacteria	S	conserved protein (some members contain a von Willebrand factor type A (vWA) domain)	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_4428545_49	1123070.KB899253_gene1114	2.129e-25	115.0	2FECS@1|root,346CJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_14	1303518.CCALI_01492	1.749e-114	377.0	COG0714@1|root,COG0714@2|Bacteria	2|Bacteria	KLT	Associated with various cellular activities	moxR2	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_4428545_68	1329516.JPST01000061_gene1729	9.085e-08	64.0	28I6X@1|root,2Z89S@2|Bacteria,1TQMI@1239|Firmicutes,4HD5B@91061|Bacilli,27CZU@186824|Thermoactinomycetaceae	91061|Bacilli	S	Domain of unknown function (DUF4350)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4350
HKD1_k127_4428545_60	1128421.JAGA01000002_gene1061	2.57e-13	81.0	2EQIM@1|root,33I4N@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4129)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4129
HKD1_k127_4428545_63	1961.JOAK01000019_gene6959	5.43e-11	74.0	COG5180@1|root,COG5180@2|Bacteria,2GKJ7@201174|Actinobacteria	201174|Actinobacteria	A	pathogenesis	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
HKD1_k127_4428545_67	1340493.JNIF01000003_gene3436	5.348e-08	64.0	COG0457@1|root,COG0457@2|Bacteria,3Y6HC@57723|Acidobacteria	1340493.JNIF01000003_gene3436|-	C	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_11	926566.Terro_1174	8.241e-129	454.0	COG1629@1|root,COG4771@2|Bacteria,3Y2M5@57723|Acidobacteria,2JMJB@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_4428545_0	234267.Acid_5396	0.0	1084.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_4428545_64	234267.Acid_1707	3.937e-10	71.0	COG0457@1|root,COG0457@2|Bacteria	234267.Acid_1707|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_6	234267.Acid_5396	1.83e-142	497.0	COG1629@1|root,COG1629@2|Bacteria	2|Bacteria	P	transport	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_4428545_3	234267.Acid_3565	1.183e-211	703.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K13735,ko:K20276	ko02024,ko05100,map02024,map05100	-	-	-	ko00000,ko00001	-	-	-	ASH,CarboxypepD_reg,DUF11,FlgD_ig,HYR,Laminin_G_3,Plug,TonB_dep_Rec
HKD1_k127_4428545_39	1340493.JNIF01000003_gene4236	4.584e-46	173.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,Methyltransf_11,Methyltransf_23,Methyltransf_25
HKD1_k127_4428545_65	292.DM42_801	1.007e-08	66.0	COG0457@1|root,COG0859@1|root,COG0457@2|Bacteria,COG0859@2|Bacteria,1MUZK@1224|Proteobacteria,2VR7H@28216|Betaproteobacteria,1K1TE@119060|Burkholderiaceae	28216|Betaproteobacteria	M	repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_11,TPR_16,TPR_2,TPR_4,TPR_8
HKD1_k127_4428545_22	243231.GSU1997	2.865e-95	328.0	COG1625@1|root,COG1625@2|Bacteria,1R76F@1224|Proteobacteria,42PNQ@68525|delta/epsilon subdivisions,2WKT9@28221|Deltaproteobacteria,43SDY@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Protein of unknown function (DUF512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
HKD1_k127_4428545_59	324602.Caur_1469	8.089e-16	83.0	COG0745@1|root,COG0745@2|Bacteria	324602.Caur_1469|-	T	phosphorelay signal transduction system	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	-
HKD1_k127_4428545_5	682795.AciX8_3666	6.331e-155	498.0	COG0686@1|root,COG0686@2|Bacteria,3Y3Y9@57723|Acidobacteria,2JI1M@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the AlaDH PNT family	-	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_4428545_16	395961.Cyan7425_2624	4.324e-109	360.0	COG0491@1|root,COG1141@1|root,COG0491@2|Bacteria,COG1141@2|Bacteria,1G3D1@1117|Cyanobacteria,3KHIR@43988|Cyanothece	1117|Cyanobacteria	C	beta-lactamase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_13
HKD1_k127_4428545_15	379066.GAU_0146	6.825e-114	391.0	COG5276@1|root,COG5492@1|root,COG5276@2|Bacteria,COG5492@2|Bacteria,1ZU8T@142182|Gemmatimonadetes	142182|Gemmatimonadetes	N	LVIVD repeat	-	-	-	-	-	-	-	-	-	-	-	-	LVIVD
HKD1_k127_4428545_54	1121012.AUKX01000010_gene1962	5.458e-19	93.0	COG2259@1|root,COG2259@2|Bacteria,4NVWM@976|Bacteroidetes,1IC7W@117743|Flavobacteriia,23HQY@178469|Arenibacter	976|Bacteroidetes	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD1_k127_4428545_23	1396141.BATP01000045_gene1794	1.593e-94	316.0	COG1131@1|root,COG1131@2|Bacteria,46U5D@74201|Verrucomicrobia,2IVHU@203494|Verrucomicrobiae	203494|Verrucomicrobiae	V	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_4428545_27	1396141.BATP01000045_gene1793	8.737e-74	269.0	28HMX@1|root,2Z7WB@2|Bacteria,46V0Q@74201|Verrucomicrobia,2IVBN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_9	379066.GAU_0147	1.621e-134	443.0	COG3391@1|root,COG3391@2|Bacteria,1ZUF6@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_47	234267.Acid_6645	3.119e-27	126.0	2DUZM@1|root,33T72@2|Bacteria,3Y7AK@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4428545_71	1340493.JNIF01000004_gene854	1.893e-05	50.0	COG1629@1|root,COG4771@2|Bacteria,3Y6CE@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_4428545_12	215803.DB30_5846	6.943e-126	413.0	COG0624@1|root,COG0624@2|Bacteria,1MVBR@1224|Proteobacteria,43BFP@68525|delta/epsilon subdivisions,2WMVT@28221|Deltaproteobacteria,2YVTT@29|Myxococcales	28221|Deltaproteobacteria	E	Peptidase dimerisation domain	argE	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4428545_8	1297742.A176_03373	1.36e-138	456.0	COG0402@1|root,COG0402@2|Bacteria,1MUFE@1224|Proteobacteria,43AI0@68525|delta/epsilon subdivisions,2X5Y7@28221|Deltaproteobacteria,2YURU@29|Myxococcales	28221|Deltaproteobacteria	F	Amidohydrolase family	hutF	-	3.5.3.13	ko:K05603	ko00340,map00340	-	R02286	RC00682	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_4428545_33	1123508.JH636440_gene2784	7.899e-51	186.0	COG3832@1|root,COG3832@2|Bacteria	2|Bacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD1_k127_4428545_31	204669.Acid345_2199	8.514e-66	235.0	COG1725@1|root,COG1725@2|Bacteria,3Y8PU@57723|Acidobacteria	57723|Acidobacteria	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K07978	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD1_k127_4428545_43	709986.Deima_0819	1.295e-32	134.0	arCOG13559@1|root,33239@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD1_k127_4428545_17	1191523.MROS_0617	5.826e-106	355.0	COG1313@1|root,COG1313@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	1.97.1.4	ko:K04070	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_4428545_51	1123371.ATXH01000001_gene1301	1.24e-22	114.0	COG0760@1|root,COG0760@2|Bacteria,2GHC2@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	O	SurA N-terminal domain	-	-	5.2.1.8	ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
HKD1_k127_4428545_20	324602.Caur_2210	1.094e-100	339.0	COG0861@1|root,COG0861@2|Bacteria,2G66P@200795|Chloroflexi,376HN@32061|Chloroflexia	32061|Chloroflexia	P	PFAM Integral membrane protein TerC	-	-	-	ko:K05794	-	-	-	-	ko00000	-	-	-	TerC
HKD1_k127_4428545_4	1045855.DSC_11095	1.297e-172	561.0	COG0471@1|root,COG3273@1|root,COG0471@2|Bacteria,COG3273@2|Bacteria,1MU0K@1224|Proteobacteria,1RMI1@1236|Gammaproteobacteria,1X4VE@135614|Xanthomonadales	135614|Xanthomonadales	P	Sodium:sulfate symporter transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS,TrkA_C
HKD1_k127_4482187_31	991.IW20_10800	5.134e-84	296.0	COG3104@1|root,COG3104@2|Bacteria,4NGWH@976|Bacteroidetes,1HY6B@117743|Flavobacteriia,2NUAF@237|Flavobacterium	976|Bacteroidetes	U	Amino acid transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD1_k127_4482187_11	582899.Hden_3175	4.047e-137	454.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD1_k127_4482187_5	1121920.AUAU01000004_gene813	1.016e-187	610.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria	57723|Acidobacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
HKD1_k127_4482187_64	880073.Calab_1042	2.143e-35	140.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_4482187_60	446471.Xcel_1959	6.835e-40	153.0	2DB76@1|root,2Z7JZ@2|Bacteria,2GKK0@201174|Actinobacteria	201174|Actinobacteria	S	T4-like virus tail tube protein gp19	-	-	-	-	-	-	-	-	-	-	-	-	Phage_T4_gp19
HKD1_k127_4482187_41	868595.Desca_1025	1.573e-62	225.0	COG0266@1|root,COG0266@2|Bacteria,1TPM9@1239|Firmicutes,24BH2@186801|Clostridia,260YT@186807|Peptococcaceae	186801|Clostridia	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD1_k127_4482187_18	1123250.KB908398_gene1462	4.034e-122	406.0	COG1109@1|root,COG1109@2|Bacteria,1UDT8@1239|Firmicutes,4H27X@909932|Negativicutes	909932|Negativicutes	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	manB	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_4482187_32	383372.Rcas_3282	3.376e-82	285.0	COG1208@1|root,COG1208@2|Bacteria,2G65W@200795|Chloroflexi,376T2@32061|Chloroflexia	32061|Chloroflexia	M	PFAM transferase hexapeptide repeat containing protein	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD1_k127_4482187_7	1198114.AciX9_1021	1.833e-157	505.0	COG0183@1|root,COG0183@2|Bacteria,3Y3SQ@57723|Acidobacteria,2JHU2@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_4482187_19	1121920.AUAU01000004_gene638	2.345e-120	392.0	COG1250@1|root,COG1250@2|Bacteria,3Y3S5@57723|Acidobacteria	57723|Acidobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_4482187_80	903818.KI912268_gene1794	1.21e-06	56.0	COG0457@1|root,COG0457@2|Bacteria,3Y8SB@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2
HKD1_k127_4482187_70	1123371.ATXH01000038_gene1358	3.481e-22	103.0	COG1399@1|root,COG1399@2|Bacteria,2GHV8@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	Uncharacterized ACR, COG1399	-	-	-	ko:K07040	-	-	-	-	ko00000	-	-	-	DUF177
HKD1_k127_4482187_72	234267.Acid_6759	1.072e-20	94.0	COG0333@1|root,COG0333@2|Bacteria,3Y5HY@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD1_k127_4482187_22	316067.Geob_2612	1.217e-111	370.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,42MU6@68525|delta/epsilon subdivisions,2WIJN@28221|Deltaproteobacteria,43S1E@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH-2	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD1_k127_4482187_23	443143.GM18_3078	6.639e-109	361.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,42MKH@68525|delta/epsilon subdivisions,2WIWQ@28221|Deltaproteobacteria,43UBD@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	TIGRFAM malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD1_k127_4482187_69	204669.Acid345_4505	2.303e-26	109.0	COG0236@1|root,COG0236@2|Bacteria,3Y54V@57723|Acidobacteria,2JJPU@204432|Acidobacteriia	204432|Acidobacteriia	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_4482187_6	234267.Acid_1167	2.358e-178	567.0	COG0304@1|root,COG0304@2|Bacteria,3Y3IS@57723|Acidobacteria	57723|Acidobacteria	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_4482187_34	204669.Acid345_3697	2.436e-78	270.0	COG2086@1|root,COG2086@2|Bacteria,3Y2PD@57723|Acidobacteria,2JK7K@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_4482187_27	204669.Acid345_3700	1.397e-103	346.0	COG2025@1|root,COG2025@2|Bacteria,3Y4SJ@57723|Acidobacteria,2JP3Y@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein FAD-binding domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD1_k127_4482187_1	234267.Acid_1818	3.017e-214	685.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase M13	-	-	3.4.24.71	ko:K01415	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD1_k127_4482187_14	66874.JOFS01000003_gene7110	5.923e-128	423.0	COG3866@1|root,COG3866@2|Bacteria,2GJEJ@201174|Actinobacteria	201174|Actinobacteria	G	pectate lyase	pel	-	4.2.2.2	ko:K01728	ko00040,ko02024,map00040,map02024	-	R02361,R06240	RC00049,RC00705	ko00000,ko00001,ko01000	-	-	-	Pec_lyase_C
HKD1_k127_4482187_45	234267.Acid_7677	2.023e-60	215.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_4482187_17	634498.mru_1002	6.821e-124	410.0	COG0477@1|root,arCOG02682@2157|Archaea,2XWP6@28890|Euryarchaeota,23PB6@183925|Methanobacteria	183925|Methanobacteria	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4482187_33	1267535.KB906767_gene2800	7.59e-79	269.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_4482187_78	861299.J421_0180	4.536e-11	63.0	COG3590@1|root,COG3590@2|Bacteria	2|Bacteria	O	peptidase	-	-	3.4.24.71	ko:K01415,ko:K07386	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD1_k127_4482187_68	215803.DB30_1995	3.958e-27	127.0	COG2931@1|root,COG4409@1|root,COG2931@2|Bacteria,COG4409@2|Bacteria,1MU7T@1224|Proteobacteria,42R1I@68525|delta/epsilon subdivisions,2WMVI@28221|Deltaproteobacteria,2YTYV@29|Myxococcales	28221|Deltaproteobacteria	GQ	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	DUF4215
HKD1_k127_4482187_43	1000565.METUNv1_01637	3.281e-61	231.0	2EMF3@1|root,2ZKNW@2|Bacteria,1RAZA@1224|Proteobacteria,2VQE2@28216|Betaproteobacteria	28216|Betaproteobacteria	S	PEP-CTERM motif	-	-	-	-	-	-	-	-	-	-	-	-	VPEP
HKD1_k127_4482187_50	945713.IALB_0020	1.188e-53	191.0	COG4747@1|root,COG4747@2|Bacteria	2|Bacteria	-	-	hom	-	1.1.1.3,1.1.1.399,1.1.1.95,1.3.1.12,4.3.1.19	ko:K00003,ko:K00058,ko:K01754,ko:K04517,ko:K04767	ko00260,ko00270,ko00290,ko00300,ko00400,ko00401,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00290,map00300,map00400,map00401,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00017,M00018,M00020,M00025,M00570	R00220,R00996,R01513,R01728,R01773,R01775	RC00031,RC00087,RC00125,RC00418,RC02600	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT,CBS,Homoserine_dh,Lactamase_B,NAD_binding_3
HKD1_k127_4482187_35	637905.SVI_0698	3.071e-78	269.0	COG0500@1|root,COG0500@2|Bacteria,1REJ2@1224|Proteobacteria,1S2QF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_4482187_36	204669.Acid345_3047	8.276e-78	270.0	COG1999@1|root,COG5569@1|root,COG1999@2|Bacteria,COG5569@2|Bacteria,3Y5CC@57723|Acidobacteria,2JHX0@204432|Acidobacteriia	204432|Acidobacteriia	S	Copper binding periplasmic protein CusF	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	CusF_Ec,SCO1-SenC
HKD1_k127_4482187_26	204669.Acid345_4424	2.022e-105	350.0	COG0190@1|root,COG0190@2|Bacteria,3Y2IN@57723|Acidobacteria,2JIT2@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_4482187_55	234267.Acid_4781	5.448e-46	174.0	COG0237@1|root,COG0237@2|Bacteria,3Y4R2@57723|Acidobacteria	57723|Acidobacteria	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD1_k127_4482187_66	251221.35214700	8.863e-30	126.0	COG4166@1|root,COG4166@2|Bacteria,1GR16@1117|Cyanobacteria	1117|Cyanobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_4482187_28	1183438.GKIL_1124	4.092e-93	318.0	COG0601@1|root,COG0601@2|Bacteria,1G01A@1117|Cyanobacteria	1117|Cyanobacteria	EP	PFAM Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033,ko:K15581,ko:K15585	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439,M00440	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD1_k127_4482187_25	251221.35214698	1.54e-106	354.0	COG1173@1|root,COG1173@2|Bacteria,1G0CD@1117|Cyanobacteria	1117|Cyanobacteria	P	'ABC-type dipeptide oligopeptide nickel transport	appC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD1_k127_4482187_15	1183438.GKIL_1122	3.704e-126	413.0	COG0444@1|root,COG0444@2|Bacteria,1G1NU@1117|Cyanobacteria	1117|Cyanobacteria	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_4482187_10	251221.35214696	4.609e-139	451.0	COG4608@1|root,COG4608@2|Bacteria,1GR1J@1117|Cyanobacteria	1117|Cyanobacteria	E	ATPases associated with a variety of cellular activities	-	-	3.6.3.24	ko:K10823,ko:K10824	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439,M00440	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_4482187_39	269799.Gmet_2721	1.423e-66	248.0	COG2199@1|root,COG2203@1|root,COG4936@1|root,COG2203@2|Bacteria,COG3706@2|Bacteria,COG4936@2|Bacteria,1MZV7@1224|Proteobacteria,43AIQ@68525|delta/epsilon subdivisions,2X5YZ@28221|Deltaproteobacteria,43W31@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PocR
HKD1_k127_4482187_74	487796.Flav2ADRAFT_1527	2.27e-13	84.0	COG2172@1|root,COG2172@2|Bacteria	2|Bacteria	T	sigma factor antagonist activity	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HKD1_k127_4482187_77	487796.Flav2ADRAFT_1528	7.173e-13	75.0	COG1366@1|root,COG1366@2|Bacteria	2|Bacteria	T	antisigma factor binding	-	-	-	-	-	-	-	-	-	-	-	-	STAS
HKD1_k127_4482187_48	204669.Acid345_2866	1.329e-55	212.0	COG2203@1|root,COG2206@1|root,COG2203@2|Bacteria,COG2206@2|Bacteria,3Y52R@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4482187_90	28532.XP_010546457.1	0.0003805	51.0	KOG2293@1|root,KOG2293@2759|Eukaryota,37MPN@33090|Viridiplantae,3GBDD@35493|Streptophyta,3HSWG@3699|Brassicales	35493|Streptophyta	KT	domain-containing protein	-	GO:0000123,GO:0000228,GO:0000785,GO:0000790,GO:0002151,GO:0003674,GO:0003676,GO:0003723,GO:0003727,GO:0004857,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0005694,GO:0005730,GO:0005737,GO:0005783,GO:0005844,GO:0006325,GO:0006464,GO:0006473,GO:0006475,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0008187,GO:0008266,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010521,GO:0010556,GO:0010558,GO:0010605,GO:0010639,GO:0012505,GO:0016043,GO:0016569,GO:0016570,GO:0016573,GO:0018193,GO:0018205,GO:0018393,GO:0018394,GO:0019219,GO:0019222,GO:0019538,GO:0030234,GO:0030425,GO:0031011,GO:0031248,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031974,GO:0031981,GO:0032204,GO:0032205,GO:0032879,GO:0032880,GO:0032991,GO:0033043,GO:0033044,GO:0033202,GO:0034046,GO:0034708,GO:0035097,GO:0036211,GO:0036477,GO:0042995,GO:0043005,GO:0043025,GO:0043086,GO:0043170,GO:0043204,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043412,GO:0043543,GO:0043967,GO:0043981,GO:0043982,GO:0043984,GO:0044092,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044297,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044444,GO:0044446,GO:0044451,GO:0044454,GO:0044463,GO:0044464,GO:0044665,GO:0045934,GO:0048518,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050794,GO:0051052,GO:0051053,GO:0051128,GO:0051129,GO:0051171,GO:0051172,GO:0051276,GO:0051338,GO:0051348,GO:0051972,GO:0051974,GO:0060255,GO:0060341,GO:0065007,GO:0065008,GO:0065009,GO:0070013,GO:0070603,GO:0070717,GO:0071339,GO:0071704,GO:0071840,GO:0080090,GO:0097159,GO:0097346,GO:0097447,GO:0097458,GO:0098772,GO:0120025,GO:0120038,GO:1900180,GO:1900182,GO:1901363,GO:1901564,GO:1902493,GO:1902494,GO:1903827,GO:1903829,GO:1904356,GO:1904357,GO:1904749,GO:1904751,GO:1904949,GO:1990234,GO:1990904,GO:2000112,GO:2000113,GO:2000278,GO:2000279,GO:2001251	-	ko:K11674	ko05168,map05168	-	-	-	ko00000,ko00001,ko03036	-	-	-	FHA,MCRS_N
HKD1_k127_4482187_67	429009.Adeg_1311	1.551e-27	128.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,42EW8@68295|Thermoanaerobacterales	186801|Clostridia	KLT	Serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_4482187_56	1144275.COCOR_03506	2.291e-42	173.0	COG0631@1|root,COG0664@1|root,COG0631@2|Bacteria,COG0664@2|Bacteria,1R7UF@1224|Proteobacteria,42WUQ@68525|delta/epsilon subdivisions,2XA41@28221|Deltaproteobacteria,2YTYP@29|Myxococcales	28221|Deltaproteobacteria	T	SMART protein phosphatase 2C domain protein	pp2c12	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2,cNMP_binding
HKD1_k127_4482187_62	306537.jk0040	1.878e-37	160.0	COG0772@1|root,COG0772@2|Bacteria,2GJTI@201174|Actinobacteria,22KAF@1653|Corynebacteriaceae	201174|Actinobacteria	D	Belongs to the SEDS family	rodA	GO:0002682,GO:0002684,GO:0008150,GO:0009605,GO:0009607,GO:0009987,GO:0035821,GO:0043207,GO:0044003,GO:0044403,GO:0044419,GO:0048518,GO:0048583,GO:0048584,GO:0050776,GO:0050778,GO:0050789,GO:0050896,GO:0051301,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052173,GO:0052200,GO:0052255,GO:0052552,GO:0052553,GO:0052555,GO:0052556,GO:0052564,GO:0052572,GO:0065007,GO:0075136	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_4482187_58	431943.CKL_3568	1.661e-40	170.0	COG0768@1|root,COG0768@2|Bacteria,1TPER@1239|Firmicutes,2486R@186801|Clostridia,36EMG@31979|Clostridiaceae	186801|Clostridia	M	Penicillin-binding Protein	pbpA2	-	-	ko:K05364	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01011	-	-	-	Transpeptidase
HKD1_k127_4482187_79	497964.CfE428DRAFT_0647	4.911e-08	63.0	COG1716@1|root,COG1716@2|Bacteria,46WW1@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	Yop-YscD_cpl
HKD1_k127_4482187_59	1449126.JQKL01000021_gene91	6.594e-40	158.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,268GU@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD1_k127_4482187_85	1123502.AQXD01000004_gene98	3.285e-05	55.0	COG3021@1|root,COG3021@2|Bacteria,1MVPP@1224|Proteobacteria,1RMBH@1236|Gammaproteobacteria,1XAVW@135614|Xanthomonadales	135614|Xanthomonadales	S	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD1_k127_4482187_84	469383.Cwoe_4169	1.26e-05	52.0	2B8XJ@1|root,32280@2|Bacteria,2HRTD@201174|Actinobacteria,4CTWV@84995|Rubrobacteria	84995|Rubrobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4482187_8	204669.Acid345_1883	1.522e-145	467.0	COG2876@1|root,COG2876@2|Bacteria,3Y32G@57723|Acidobacteria,2JIXH@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_4482187_4	1267535.KB906767_gene1458	3.559e-192	622.0	COG0018@1|root,COG0018@2|Bacteria,3Y35R@57723|Acidobacteria,2JIAM@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_4482187_40	1379698.RBG1_1C00001G0228	2.606e-63	226.0	COG0846@1|root,COG0846@2|Bacteria,2NPJR@2323|unclassified Bacteria	2|Bacteria	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	GO:0000726,GO:0003674,GO:0003824,GO:0003953,GO:0005575,GO:0005618,GO:0005623,GO:0006139,GO:0006259,GO:0006281,GO:0006302,GO:0006303,GO:0006464,GO:0006471,GO:0006476,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009314,GO:0009628,GO:0009987,GO:0010212,GO:0016787,GO:0016798,GO:0016799,GO:0019213,GO:0019538,GO:0030312,GO:0033554,GO:0033558,GO:0034641,GO:0034979,GO:0035601,GO:0036211,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0070213,GO:0071214,GO:0071478,GO:0071479,GO:0071704,GO:0071944,GO:0090304,GO:0098732,GO:0104004,GO:0140096,GO:1901360,GO:1901564	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD1_k127_4482187_24	246194.CHY_1283	1.232e-106	358.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,42FR9@68295|Thermoanaerobacterales	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_4482187_38	1121422.AUMW01000003_gene828	3.721e-69	240.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,25ZXN@186807|Peptococcaceae	186801|Clostridia	H	PFAM GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_4482187_61	204669.Acid345_2222	5.544e-38	149.0	COG2322@1|root,COG2322@2|Bacteria,3Y4U9@57723|Acidobacteria,2JJKU@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF420)	-	-	-	ko:K08976	-	-	-	-	ko00000	-	-	-	DUF420
HKD1_k127_4482187_52	234267.Acid_5454	8.3e-53	196.0	COG0511@1|root,COG1413@1|root,COG0511@2|Bacteria,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	pcmV	-	2.3.1.12	ko:K00627,ko:K02160,ko:K07402	ko00010,ko00020,ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00010,map00020,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00307,M00376	R00209,R00742,R02569	RC00004,RC00040,RC00367,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,MDMPI_C,MDMPI_N,XdhC_C,XdhC_CoxI
HKD1_k127_4482187_37	234267.Acid_3219	4.982e-70	272.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4482187_76	1353276.JADR01000011_gene1575	4.36e-13	84.0	COG1345@1|root,COG3420@1|root,COG4677@1|root,COG1345@2|Bacteria,COG3420@2|Bacteria,COG4677@2|Bacteria,4NGSK@976|Bacteroidetes,1HXWK@117743|Flavobacteriia	976|Bacteroidetes	N	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	Flg_new,LTD
HKD1_k127_4482187_29	234267.Acid_3582	3.243e-92	331.0	COG4262@1|root,COG4262@2|Bacteria,3Y6HM@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4482187_53	234267.Acid_3885	2.889e-48	177.0	COG1245@1|root,COG1245@2|Bacteria	2|Bacteria	C	4Fe-4S binding domain	rnfB	-	1.8.99.2	ko:K00395,ko:K02572,ko:K03616	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00596	R00860,R04927,R08553	RC00007,RC01239,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	FeS,Fer4,Fer4_4,Fer4_7
HKD1_k127_4482187_63	1121904.ARBP01000012_gene1388	2.063e-36	150.0	COG0697@1|root,COG0697@2|Bacteria,4NGZ3@976|Bacteroidetes,47PHD@768503|Cytophagia	976|Bacteroidetes	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4482187_20	1379270.AUXF01000004_gene3130	2.191e-119	397.0	COG0508@1|root,COG0508@2|Bacteria,1ZSYJ@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_4482187_13	1411123.JQNH01000001_gene1359	6.515e-132	428.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
HKD1_k127_4482187_21	671143.DAMO_1598	3.143e-119	394.0	COG1071@1|root,COG1071@2|Bacteria,2NQC2@2323|unclassified Bacteria	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD1_k127_4482187_16	1198114.AciX9_2892	1.18e-125	434.0	COG2199@1|root,COG2203@1|root,COG3437@1|root,COG2199@2|Bacteria,COG2203@2|Bacteria,COG3437@2|Bacteria,3Y9F7@57723|Acidobacteria	57723|Acidobacteria	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF
HKD1_k127_4482187_0	266117.Rxyl_2540	1.809e-237	752.0	COG1331@1|root,COG1331@2|Bacteria,2GJ88@201174|Actinobacteria,4CPJ8@84995|Rubrobacteria	84995|Rubrobacteria	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_4482187_12	204669.Acid345_4530	5.297e-134	455.0	COG4805@1|root,COG4805@2|Bacteria,3Y4PP@57723|Acidobacteria,2JKV8@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4482187_54	903818.KI912268_gene1906	6.183e-48	181.0	2D4UK@1|root,32THN@2|Bacteria,3Y59Q@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3142
HKD1_k127_4482187_88	555779.Dthio_PD2550	0.0002127	46.0	COG0551@1|root,COG0551@2|Bacteria,1RJ2N@1224|Proteobacteria,42T7M@68525|delta/epsilon subdivisions,2WPTS@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_4482187_3	1382359.JIAL01000001_gene1741	3.262e-195	624.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,3Y5CQ@57723|Acidobacteria,2JKVX@204432|Acidobacteriia	204432|Acidobacteriia	C	Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO
HKD1_k127_4482187_89	401526.TcarDRAFT_2085	0.0002916	46.0	COG1758@1|root,COG1758@2|Bacteria,1VK74@1239|Firmicutes,4H5NB@909932|Negativicutes	909932|Negativicutes	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_4482187_51	1125863.JAFN01000001_gene1800	2.47e-53	197.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,42R4H@68525|delta/epsilon subdivisions,2WNAD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	Essential for recycling GMP and indirectly, cGMP	gmk	GO:0003674,GO:0003824,GO:0004385,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009126,GO:0009132,GO:0009135,GO:0009150,GO:0009161,GO:0009165,GO:0009167,GO:0009179,GO:0009185,GO:0009259,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0042278,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046037,GO:0046128,GO:0046483,GO:0046710,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072521,GO:0090407,GO:1901068,GO:1901135,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901576,GO:1901657	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD1_k127_4482187_46	340099.Teth39_1326	4.176e-60	218.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,42EU9@68295|Thermoanaerobacterales	186801|Clostridia	S	domain protein	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_4482187_9	926566.Terro_2757	7.602e-144	477.0	COG1132@1|root,COG1132@2|Bacteria,3Y2Y9@57723|Acidobacteria,2JI79@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K11085	ko02010,map02010	-	-	-	ko00000,ko00001,ko01000,ko02000	3.A.1.106	-	-	ABC_membrane,ABC_tran
HKD1_k127_4482187_49	292459.STH750	3.427e-54	202.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia	186801|Clostridia	K	response regulator receiver	phoP	-	-	ko:K02483,ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4482187_87	945713.IALB_2039	0.0001824	54.0	COG1361@1|root,COG1520@1|root,COG1361@2|Bacteria,COG1520@2|Bacteria	2|Bacteria	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	CHU_C,Cohesin,DUF11,Peptidase_S8,SBBP,SLH,VCBS
HKD1_k127_4482187_57	1267535.KB906767_gene3577	5.723e-42	173.0	COG2885@1|root,COG2885@2|Bacteria,3Y2WJ@57723|Acidobacteria,2JJYF@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_4482187_30	204669.Acid345_0050	2.657e-89	304.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD1_k127_4482187_42	234267.Acid_2131	4.007e-62	220.0	COG1720@1|root,COG1720@2|Bacteria,3Y5T1@57723|Acidobacteria	57723|Acidobacteria	S	Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_4482187_82	1122223.KB890688_gene1665	6.343e-06	58.0	COG0457@1|root,COG0457@2|Bacteria,1WIGW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HKD1_k127_4482187_71	1267533.KB906738_gene2305	2.875e-21	100.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD1_k127_4482187_65	1429851.X548_19835	2.55e-35	143.0	COG4319@1|root,COG4319@2|Bacteria,1QG6G@1224|Proteobacteria,1TDJB@1236|Gammaproteobacteria,1XAW4@135614|Xanthomonadales	135614|Xanthomonadales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_4482187_2	1123242.JH636434_gene5497	2.874e-197	635.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2IXK8@203682|Planctomycetes	203682|Planctomycetes	E	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_4482187_83	1173027.Mic7113_0190	1.11e-05	56.0	COG0515@1|root,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H7V1@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	Pkinase,WD40
HKD1_k127_4482187_44	247490.KSU1_B0364	3.816e-61	235.0	COG4191@1|root,COG4191@2|Bacteria,2J2BM@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_4484073_66	1040983.AXAE01000027_gene5178	2.503e-66	253.0	COG3468@1|root,COG3468@2|Bacteria,1QUZ3@1224|Proteobacteria,2U1BI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MU	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,TIG
HKD1_k127_4484073_119	314265.R2601_20441	6.434e-25	122.0	COG2706@1|root,COG2706@2|Bacteria,1QYRS@1224|Proteobacteria	1224|Proteobacteria	G	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_41	861299.J421_5995	1.95e-116	402.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	AAA_16,Abhydrolase_1,PD40,Trans_reg_C
HKD1_k127_4484073_123	1121015.N789_05565	8.39e-20	96.0	2EU3C@1|root,33MK6@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_81	1301098.PKB_2099	9.558e-55	195.0	COG0662@1|root,COG0662@2|Bacteria,1N1YZ@1224|Proteobacteria	1224|Proteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_4484073_152	204669.Acid345_3584	0.0009153	44.0	COG0346@1|root,COG0346@2|Bacteria,3Y5YF@57723|Acidobacteria,2JNP7@204432|Acidobacteriia	204432|Acidobacteriia	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4484073_144	649638.Trad_0710	1.929e-05	46.0	COG4634@1|root,COG4634@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_95	296591.Bpro_4771	1.154e-43	162.0	2DQ44@1|root,334NC@2|Bacteria,1NCSR@1224|Proteobacteria,2VUY0@28216|Betaproteobacteria,4AF7Q@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF962
HKD1_k127_4484073_124	768671.ThimaDRAFT_3543	1.672e-19	91.0	2DS06@1|root,33DXP@2|Bacteria,1NJMQ@1224|Proteobacteria,1SJ5T@1236|Gammaproteobacteria,1X288@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_129	471854.Dfer_0118	3.396e-14	79.0	29XQK@1|root,30JGA@2|Bacteria,4NNS6@976|Bacteroidetes,47SDP@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_33	105559.Nwat_0061	1.08e-129	422.0	COG4974@1|root,COG4974@2|Bacteria,1MVAN@1224|Proteobacteria,1RMSS@1236|Gammaproteobacteria,1WWP3@135613|Chromatiales	135613|Chromatiales	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_4,Phage_integrase
HKD1_k127_4484073_78	1191523.MROS_1301	5.875e-57	201.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_4484073_51	861299.J421_5995	1.738e-89	322.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	AAA_16,Abhydrolase_1,PD40,Trans_reg_C
HKD1_k127_4484073_109	234267.Acid_3392	1.285e-32	137.0	2E74W@1|root,331P9@2|Bacteria,3Y8XR@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HKD1_k127_4484073_31	1267535.KB906767_gene4174	3.034e-138	459.0	COG3064@1|root,COG3064@2|Bacteria,3Y3WX@57723|Acidobacteria	57723|Acidobacteria	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_102	234267.Acid_1757	4.134e-39	152.0	COG0789@1|root,COG0789@2|Bacteria,3Y5XK@57723|Acidobacteria	57723|Acidobacteria	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR,MerR-DNA-bind
HKD1_k127_4484073_85	234267.Acid_1758	4.971e-53	194.0	COG3245@1|root,COG3245@2|Bacteria,3Y5B1@57723|Acidobacteria	57723|Acidobacteria	C	cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_0	671143.DAMO_1933	0.0	1395.0	COG0841@1|root,COG0841@2|Bacteria,2NNUH@2323|unclassified Bacteria	2|Bacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_4484073_48	671143.DAMO_1932	1.777e-92	318.0	COG0845@1|root,COG0845@2|Bacteria,2NPS3@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_4484073_72	671143.DAMO_1931	1.614e-59	224.0	COG1538@1|root,COG1538@2|Bacteria,2NPKK@2323|unclassified Bacteria	2|Bacteria	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_4484073_122	234267.Acid_4150	9.566e-21	95.0	COG0607@1|root,32YCZ@2|Bacteria,3Y5Z1@57723|Acidobacteria	57723|Acidobacteria	P	Protein of unknown function (DUF2892)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2892
HKD1_k127_4484073_114	204669.Acid345_2970	5.242e-29	120.0	COG0640@1|root,COG0640@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HKD1_k127_4484073_116	264201.pc0548	4.171e-27	114.0	COG1186@1|root,COG1186@2|Bacteria,2JH72@204428|Chlamydiae	204428|Chlamydiae	J	RF-1 domain	-	-	-	-	-	-	-	-	-	-	-	-	RF-1
HKD1_k127_4484073_44	1123257.AUFV01000011_gene3189	3.202e-106	351.0	COG0564@1|root,COG0564@2|Bacteria,1MX5Y@1224|Proteobacteria,1RZXE@1236|Gammaproteobacteria,1X44N@135614|Xanthomonadales	135614|Xanthomonadales	J	Pseudouridylate	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD1_k127_4484073_148	1048339.KB913029_gene2233	0.0001297	53.0	2CIBE@1|root,32S7P@2|Bacteria,2IRU5@201174|Actinobacteria,4ET6C@85013|Frankiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_77	1268240.ATFI01000001_gene2802	9.234e-59	226.0	COG1621@1|root,COG1621@2|Bacteria,4NI6T@976|Bacteroidetes,2FP34@200643|Bacteroidia,4AQGS@815|Bacteroidaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_32N,Glyco_hydro_43
HKD1_k127_4484073_49	661478.OP10G_2561	1.648e-90	321.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cellulase,Lipase_GDSL_2,PA14,RicinB_lectin_2
HKD1_k127_4484073_17	1123248.KB893370_gene5031	6.267e-194	612.0	COG4941@1|root,COG4941@2|Bacteria,4NGCS@976|Bacteroidetes,1IRPG@117747|Sphingobacteriia	976|Bacteroidetes	K	PFAM RNA polymerase sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4484073_73	1123248.KB893370_gene5032	2.464e-59	206.0	COG3795@1|root,COG3795@2|Bacteria,4NQPY@976|Bacteroidetes,1IYMH@117747|Sphingobacteriia	976|Bacteroidetes	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_4484073_86	342113.DM82_812	4.191e-52	190.0	COG0406@1|root,COG0406@2|Bacteria,1RH8P@1224|Proteobacteria,2VUH5@28216|Betaproteobacteria,1K8ZG@119060|Burkholderiaceae	28216|Betaproteobacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_149	197221.22294138	0.0001452	49.0	COG1565@1|root,COG1565@2|Bacteria,1G16Z@1117|Cyanobacteria	1117|Cyanobacteria	S	acr, cog1565	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_28
HKD1_k127_4484073_130	113395.AXAI01000008_gene766	4.385e-14	73.0	COG5362@1|root,COG5410@1|root,COG5362@2|Bacteria,COG5410@2|Bacteria,1NKZK@1224|Proteobacteria,2U0EG@28211|Alphaproteobacteria,3JXF7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Terminase RNaseH-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Terminase_6C
HKD1_k127_4484073_142	330214.NIDE3547	2.61e-06	58.0	COG0582@1|root,COG0582@2|Bacteria,3J133@40117|Nitrospirae	40117|Nitrospirae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_4484073_134	1267535.KB906767_gene1270	2.612e-10	64.0	COG4974@1|root,COG4974@2|Bacteria	2|Bacteria	L	Belongs to the 'phage' integrase family	intE	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_1,Phage_int_SAM_1,Phage_integrase
HKD1_k127_4484073_32	1121920.AUAU01000002_gene2082	1.002e-132	447.0	COG0488@1|root,COG0488@2|Bacteria,3Y340@57723|Acidobacteria	57723|Acidobacteria	S	PFAM ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_4484073_113	1382359.JIAL01000001_gene1910	6.968e-31	136.0	COG0760@1|root,COG0760@2|Bacteria,3Y42Z@57723|Acidobacteria,2JHQ4@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N_3
HKD1_k127_4484073_121	309803.CTN_0431	6.397e-21	98.0	COG0227@1|root,COG0227@2|Bacteria,2GDFC@200918|Thermotogae	200918|Thermotogae	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD1_k127_4484073_94	264732.Moth_1495	6.46e-44	163.0	COG0251@1|root,COG0251@2|Bacteria,1V6HG@1239|Firmicutes,24J8Y@186801|Clostridia,42GJ3@68295|Thermoanaerobacterales	186801|Clostridia	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_4484073_20	1382359.JIAL01000001_gene3036	1.782e-169	544.0	COG0308@1|root,COG0308@2|Bacteria,3Y3ZS@57723|Acidobacteria,2JK79@204432|Acidobacteriia	204432|Acidobacteriia	E	Phospholipase B	-	-	-	-	-	-	-	-	-	-	-	-	Phospholip_B
HKD1_k127_4484073_75	926566.Terro_3254	4.709e-59	214.0	COG1484@1|root,COG1484@2|Bacteria,3Y3EK@57723|Acidobacteria,2JI9M@204432|Acidobacteriia	204432|Acidobacteriia	L	IstB-like ATP binding protein	-	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HKD1_k127_4484073_58	1267533.KB906733_gene3211	1.203e-75	259.0	COG0221@1|root,COG0221@2|Bacteria,3Y3UZ@57723|Acidobacteria,2JIJK@204432|Acidobacteriia	204432|Acidobacteriia	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD1_k127_4484073_131	338963.Pcar_1063	3.039e-13	74.0	COG1734@1|root,COG1734@2|Bacteria,1Q48Z@1224|Proteobacteria,43E2S@68525|delta/epsilon subdivisions,2WWWM@28221|Deltaproteobacteria,43VKD@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_4484073_59	1173026.Glo7428_1817	1.699e-73	255.0	COG0730@1|root,COG0730@2|Bacteria,1G72I@1117|Cyanobacteria	1117|Cyanobacteria	S	Sulfite exporter TauE/SafE	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_4484073_46	1167006.UWK_00452	2.813e-97	327.0	COG1899@1|root,COG1899@2|Bacteria,1R3WQ@1224|Proteobacteria,42M57@68525|delta/epsilon subdivisions,2WJ6N@28221|Deltaproteobacteria,2MHW7@213118|Desulfobacterales	28221|Deltaproteobacteria	O	peptidyl-lysine modification to peptidyl-hypusine	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_5	234267.Acid_7263	0.0	1244.0	COG0178@1|root,COG0178@2|Bacteria,3Y3G9@57723|Acidobacteria	57723|Acidobacteria	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_4484073_101	1499967.BAYZ01000080_gene947	2.197e-40	158.0	COG0558@1|root,COG0558@2|Bacteria,2NPJ9@2323|unclassified Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	iIT341.HP1016	CDP-OH_P_transf
HKD1_k127_4484073_56	204669.Acid345_2567	1.292e-76	273.0	COG4783@1|root,COG4783@2|Bacteria,3Y3GF@57723|Acidobacteria,2JI98@204432|Acidobacteriia	204432|Acidobacteriia	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD1_k127_4484073_98	1121423.JONT01000026_gene889	7.904e-42	168.0	COG5495@1|root,COG5495@2|Bacteria,1UZZU@1239|Firmicutes,249YF@186801|Clostridia,261DG@186807|Peptococcaceae	186801|Clostridia	S	Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2520,F420_oxidored,Rossmann-like
HKD1_k127_4484073_150	1266909.AUAG01000004_gene2097	0.0002171	48.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1WWQ4@135613|Chromatiales	135613|Chromatiales	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_4484073_141	426114.THI_1455	2.522e-06	55.0	2EIG1@1|root,33C7D@2|Bacteria,1NNA9@1224|Proteobacteria,2W607@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_14	1499967.BAYZ01000039_gene2237	6.897e-212	678.0	COG0272@1|root,COG0272@2|Bacteria,2NNSW@2323|unclassified Bacteria	2|Bacteria	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	GO:0003674,GO:0003824,GO:0003909,GO:0003911,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006266,GO:0006281,GO:0006284,GO:0006288,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009987,GO:0016874,GO:0016886,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0090304,GO:0140097,GO:1901360	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD1_k127_4484073_97	278963.ATWD01000002_gene684	5.5e-42	164.0	COG3375@1|root,COG3375@2|Bacteria,3Y41E@57723|Acidobacteria,2JI86@204432|Acidobacteriia	204432|Acidobacteriia	S	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_4484073_136	530564.Psta_2705	1.133e-08	61.0	COG0642@1|root,COG5000@1|root,COG2205@2|Bacteria,COG5000@2|Bacteria,2IXA1@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3365,HAMP,HATPase_c,HisKA
HKD1_k127_4484073_107	1267533.KB906733_gene2808	2.615e-34	139.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	-	-	5.3.4.1	ko:K01829,ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko01000,ko03110	-	-	-	Thioredoxin_7
HKD1_k127_4484073_18	234267.Acid_5781	8.755e-192	612.0	COG1032@1|root,COG1032@2|Bacteria	2|Bacteria	C	radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_4484073_2	1267535.KB906767_gene717	0.0	1375.0	COG0458@1|root,COG0458@2|Bacteria,3Y3GG@57723|Acidobacteria,2JIJZ@204432|Acidobacteriia	204432|Acidobacteriia	F	TIGRFAM carbamoyl-phosphate synthase, large subunit	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_4484073_91	1121423.JONT01000006_gene2431	1.426e-45	171.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,261XV@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM molybdenum cofactor synthesis	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
HKD1_k127_4484073_104	240292.Ava_4725	5.996e-39	170.0	COG2931@1|root,COG2931@2|Bacteria,1GIZT@1117|Cyanobacteria,1HMI7@1161|Nostocales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VCBS
HKD1_k127_4484073_90	1122138.AQUZ01000008_gene3682	2.799e-48	201.0	COG1361@1|root,COG1361@2|Bacteria,2I8F1@201174|Actinobacteria,4DVAH@85009|Propionibacteriales	201174|Actinobacteria	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11
HKD1_k127_4484073_151	6334.EFV57079	0.0002584	55.0	KOG4441@1|root,KOG4441@2759|Eukaryota,39V6V@33154|Opisthokonta,3BD1Q@33208|Metazoa,3D1G3@33213|Bilateria,40ANA@6231|Nematoda	33208|Metazoa	T	BTB And C-terminal Kelch	KLHL8	GO:0000151,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005654,GO:0006464,GO:0006508,GO:0006511,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009987,GO:0014069,GO:0016567,GO:0019538,GO:0019941,GO:0030163,GO:0031461,GO:0031463,GO:0031974,GO:0031981,GO:0032279,GO:0032446,GO:0032991,GO:0036211,GO:0036477,GO:0042995,GO:0043005,GO:0043025,GO:0043170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0043412,GO:0043632,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044297,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044456,GO:0044464,GO:0045202,GO:0051603,GO:0070013,GO:0070647,GO:0071704,GO:0097458,GO:0098794,GO:0098984,GO:0099572,GO:0120025,GO:1901564,GO:1901565,GO:1901575,GO:1902494,GO:1990234	-	ko:K10446	-	-	-	-	ko00000,ko04121	-	-	-	BACK,BTB,Kelch_1
HKD1_k127_4484073_110	240292.Ava_4725	1.591e-32	148.0	COG2931@1|root,COG2931@2|Bacteria,1GIZT@1117|Cyanobacteria,1HMI7@1161|Nostocales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,VCBS
HKD1_k127_4484073_127	999411.HMPREF1092_02916	1.727e-16	95.0	COG1361@1|root,COG1361@2|Bacteria,1UQ5B@1239|Firmicutes,24AUI@186801|Clostridia,36DY0@31979|Clostridiaceae	186801|Clostridia	M	Domain of unknown function DUF11	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,DUF3794,SdrD_B
HKD1_k127_4484073_111	1162668.LFE_1700	5.02e-32	130.0	COG0838@1|root,COG0838@2|Bacteria,3J0MS@40117|Nitrospirae	40117|Nitrospirae	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_4484073_65	1121920.AUAU01000016_gene1317	1.682e-66	232.0	COG0377@1|root,COG0377@2|Bacteria,3Y3JS@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_4484073_132	1382359.JIAL01000001_gene180	3.049e-13	78.0	COG2823@1|root,COG2823@2|Bacteria,3Y7Q9@57723|Acidobacteria,2JMV8@204432|Acidobacteriia	204432|Acidobacteriia	S	Periplasmic or secreted lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_4484073_92	234267.Acid_4096	2.208e-45	171.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4484073_79	661478.OP10G_0672	3.949e-56	210.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2,zf-HC2
HKD1_k127_4484073_57	234267.Acid_4621	5.212e-76	269.0	29ZE1@1|root,30MD7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_105	269798.CHU_0700	1.084e-37	147.0	COG2010@1|root,COG2010@2|Bacteria,4NQN1@976|Bacteroidetes,47XSN@768503|Cytophagia	976|Bacteroidetes	C	Haem-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Haem_bd
HKD1_k127_4484073_26	1379698.RBG1_1C00001G0798	2.325e-149	505.0	COG0308@1|root,COG1413@1|root,COG0308@2|Bacteria,COG1413@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	HEAT_2,Peptidase_M1
HKD1_k127_4484073_60	309807.SRU_2488	2.411e-70	246.0	COG0745@1|root,COG0745@2|Bacteria,4NIQC@976|Bacteroidetes,1FK2H@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	K	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4484073_138	861299.J421_0243	1.27e-07	64.0	COG1413@1|root,COG4219@1|root,COG1413@2|Bacteria,COG4219@2|Bacteria,1ZUUA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	U	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,Peptidase_M56
HKD1_k127_4484073_147	1227487.C474_09984	0.0001283	55.0	COG5635@1|root,arCOG02967@2157|Archaea,2Y7N5@28890|Euryarchaeota,240VC@183963|Halobacteria	183963|Halobacteria	T	repeat-containing protein	-	-	-	ko:K22221	-	-	-	-	ko00000	-	-	-	HEAT_2,HEAT_PBS
HKD1_k127_4484073_140	1280941.HY2_01135	1.272e-06	62.0	COG1020@1|root,COG1020@2|Bacteria,1QK4F@1224|Proteobacteria,2TZU8@28211|Alphaproteobacteria,440W7@69657|Hyphomonadaceae	1224|Proteobacteria	Q	Belongs to the ATP-dependent AMP-binding enzyme family	-	-	-	ko:K12436,ko:K13611	-	-	-	-	ko00000,ko01004,ko01008	-	-	-	AMP-binding,AMP-binding_C,Acyl_transf_1,Condensation,KAsynt_C_assoc,KR,Ketoacyl-synt_C,Methyltransf_12,PP-binding,PS-DH,Thioesterase,ketoacyl-synt
HKD1_k127_4484073_6	1499967.BAYZ01000167_gene6718	6.008e-276	863.0	COG0556@1|root,COG0556@2|Bacteria,2NNPM@2323|unclassified Bacteria	2|Bacteria	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009314,GO:0009380,GO:0009628,GO:0032991,GO:0042802,GO:0044424,GO:0044464,GO:0050896,GO:1902494,GO:1905347,GO:1905348,GO:1990391	-	ko:K03702,ko:K08999	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_4484073_24	1519464.HY22_10910	1.77e-157	512.0	COG0277@1|root,COG0277@2|Bacteria,1FDCI@1090|Chlorobi	1090|Chlorobi	C	PFAM FAD linked oxidase domain protein	-	-	1.1.2.4	ko:K00102	ko00620,map00620	-	R00197	RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_4484073_28	1267535.KB906767_gene3956	2.092e-144	467.0	COG0082@1|root,COG0082@2|Bacteria,3Y2Z8@57723|Acidobacteria,2JINW@204432|Acidobacteriia	204432|Acidobacteriia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD1_k127_4484073_80	1382359.JIAL01000001_gene476	2.217e-55	199.0	COG0242@1|root,COG0242@2|Bacteria,3Y4HY@57723|Acidobacteria,2JJ9D@204432|Acidobacteriia	204432|Acidobacteriia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD1_k127_4484073_13	1089548.KI783301_gene190	1.033e-214	678.0	COG1012@1|root,COG1012@2|Bacteria,1TP4S@1239|Firmicutes,4HBS1@91061|Bacilli,3WFDZ@539002|Bacillales incertae sedis	91061|Bacilli	C	Catalyzes the conversion of 1-proline-5-carboxylate dehydrogenase to L-glutamate	rocA	-	1.2.1.88	ko:K00294	ko00250,ko00330,ko01100,map00250,map00330,map01100	-	R00245,R00707,R00708,R04444,R04445,R05051	RC00080,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD1_k127_4484073_53	768670.Calni_0073	2.297e-87	300.0	COG0223@1|root,COG0223@2|Bacteria,2GF1I@200930|Deferribacteres	200930|Deferribacteres	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD1_k127_4484073_137	329726.AM1_2294	4.2e-08	63.0	COG0515@1|root,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_4484073_47	1297742.A176_02115	1.64e-95	343.0	COG0421@1|root,COG0421@2|Bacteria,1QX98@1224|Proteobacteria,43C2D@68525|delta/epsilon subdivisions,2X7CZ@28221|Deltaproteobacteria,2Z3FM@29|Myxococcales	28221|Deltaproteobacteria	E	Spermine/spermidine synthase domain	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synth
HKD1_k127_4484073_84	204669.Acid345_0630	4.186e-53	205.0	COG1721@1|root,COG1721@2|Bacteria,3Y5V9@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF58	-	-	-	-	-	-	-	-	-	-	-	-	DUF58
HKD1_k127_4484073_42	1499967.BAYZ01000105_gene3512	1.111e-115	383.0	COG0714@1|root,COG0714@2|Bacteria,2NNMQ@2323|unclassified Bacteria	2|Bacteria	S	ATPase associated with various cellular	-	-	-	ko:K03924	-	-	-	-	ko00000,ko01000	-	-	-	AAA_3
HKD1_k127_4484073_139	309799.DICTH_0725	2.132e-07	59.0	COG4968@1|root,COG4968@2|Bacteria	2|Bacteria	NU	Prokaryotic N-terminal methylation motif	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	Lectin_C,N_methyl,SBP_bac_10,T2SSG
HKD1_k127_4484073_108	509190.Cseg_3249	2.043e-33	141.0	COG1876@1|root,COG1876@2|Bacteria,1N1CQ@1224|Proteobacteria,2U7GA@28211|Alphaproteobacteria,2KGBW@204458|Caulobacterales	204458|Caulobacterales	M	PFAM peptidase M15B and M15C DD-carboxypeptidase VanY endolysin	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,VanY
HKD1_k127_4484073_52	1173022.Cri9333_3375	1.125e-87	304.0	COG2201@1|root,COG2201@2|Bacteria,1G3H5@1117|Cyanobacteria,1HAH2@1150|Oscillatoriales	1117|Cyanobacteria	NT	CheB methylesterase	-	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest
HKD1_k127_4484073_106	261292.Nit79A3_2343	3.482e-36	157.0	COG0028@1|root,COG0028@2|Bacteria	2|Bacteria	EH	Belongs to the TPP enzyme family	-	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	Laminin_G_3,PKD,TIG,TPP_enzyme_M,fn3
HKD1_k127_4484073_133	324602.Caur_1388	1.96e-10	74.0	COG1361@1|root,COG1404@1|root,COG2373@1|root,COG2931@1|root,COG3266@1|root,COG1361@2|Bacteria,COG1404@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3266@2|Bacteria	2|Bacteria	GM	domain, Protein	bhp	-	3.4.24.40,3.5.1.28	ko:K01406,ko:K01448,ko:K13735,ko:K20276,ko:K21449	ko01503,ko02024,ko05100,map01503,map02024,map05100	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko02000,ko03036	1.B.40.2	-	-	Big_5,Calx-beta,DUF4347,SLH
HKD1_k127_4484073_19	1454004.AW11_02556	3.414e-184	584.0	COG0626@1|root,COG0626@2|Bacteria	2|Bacteria	E	cystathionine gamma-synthase activity	megL	-	2.5.1.48,2.5.1.49,4.4.1.11,4.4.1.8	ko:K01739,ko:K01740,ko:K01760,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00782,R00999,R01286,R01287,R01288,R02408,R02508,R03217,R03260,R04770,R04859,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00382,RC00420,RC00488,RC00710,RC01209,RC01210,RC01245,RC02303,RC02821,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_4484073_103	1869.MB27_30450	4.718e-39	154.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria	201174|Actinobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_4484073_71	682795.AciX8_2613	3.422e-61	222.0	COG1127@1|root,COG1127@2|Bacteria,3Y3YI@57723|Acidobacteria,2JIF1@204432|Acidobacteriia	204432|Acidobacteriia	Q	ABC transporter	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD1_k127_4484073_112	330214.NIDE3982	6.591e-31	127.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
HKD1_k127_4484073_61	204669.Acid345_4067	2.605e-70	244.0	COG2197@1|root,COG2197@2|Bacteria,3Y7QM@57723|Acidobacteria,2JMPR@204432|Acidobacteriia	204432|Acidobacteriia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4484073_74	1267534.KB906754_gene2942	4.461e-59	226.0	COG2202@1|root,COG4585@1|root,COG2202@2|Bacteria,COG4585@2|Bacteria,3Y4XJ@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,PAS_9
HKD1_k127_4484073_143	1158604.I591_00370	2.905e-06	53.0	COG1359@1|root,COG1359@2|Bacteria,1VG4T@1239|Firmicutes,4HPNQ@91061|Bacilli,4B3WN@81852|Enterococcaceae	91061|Bacilli	S	Antibiotic biosynthesis monooxygenase	ycnE	GO:0003674,GO:0003824	-	-	-	-	-	-	-	-	-	-	ABM
HKD1_k127_4484073_36	1499967.BAYZ01000167_gene6760	1.063e-124	445.0	COG2204@1|root,COG3829@1|root,COG2204@2|Bacteria,COG3829@2|Bacteria	2|Bacteria	T	transcription factor binding	-	-	-	ko:K15836	-	-	-	-	ko00000,ko03000	-	-	-	GAF_2,HTH_8,PAS_9,Response_reg,Sigma54_activat
HKD1_k127_4484073_7	401053.AciPR4_2597	3.481e-261	839.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria,2JKKF@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_4484073_126	234267.Acid_3392	8.612e-17	89.0	2E74W@1|root,331P9@2|Bacteria,3Y8XR@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2490)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2490
HKD1_k127_4484073_25	929556.Solca_1935	3.493e-151	507.0	COG5164@1|root,COG5164@2|Bacteria,4NFN0@976|Bacteroidetes	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_89	926566.Terro_3982	4.14e-49	185.0	2DI5H@1|root,3023A@2|Bacteria,3Y92W@57723|Acidobacteria,2JNT1@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_54	1210884.HG799469_gene14128	3.977e-85	297.0	COG4325@1|root,COG4325@2|Bacteria,2IZ4R@203682|Planctomycetes	203682|Planctomycetes	S	Predicted membrane protein (DUF2254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2254
HKD1_k127_4484073_128	243233.MCA0469	1.648e-14	81.0	2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD1_k127_4484073_118	1396141.BATP01000001_gene5388	5.366e-27	116.0	COG1226@1|root,3171K@2|Bacteria,46WQS@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_4484073_55	1396418.BATQ01000045_gene6036	1.449e-78	279.0	COG0845@1|root,COG0845@2|Bacteria,46UGE@74201|Verrucomicrobia,2IVKB@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_4484073_3	1304885.AUEY01000002_gene358	0.0	1299.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJVV@28221|Deltaproteobacteria,2MI2Z@213118|Desulfobacterales	28221|Deltaproteobacteria	V	Hydrophobe Amphiphile Efflux-1 (HAE1) Family	bepE	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_4484073_37	1267535.KB906767_gene1084	1.724e-123	412.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NR@57723|Acidobacteria,2JHZY@204432|Acidobacteriia	204432|Acidobacteriia	MU	TIGRFAM RND efflux system, outer membrane lipoprotein, NodT	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_4484073_29	497964.CfE428DRAFT_5240	3.708e-143	460.0	COG2326@1|root,COG2326@2|Bacteria,46SAH@74201|Verrucomicrobia	74201|Verrucomicrobia	S	Polyphosphate kinase 2 (PPK2)	-	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_4484073_12	1396141.BATP01000001_gene5389	9.557e-236	743.0	COG0659@1|root,COG0659@2|Bacteria,46TUB@74201|Verrucomicrobia,2IVJF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_4484073_100	1042326.AZNV01000004_gene4029	1.86e-40	158.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,4BCYP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_4484073_93	1267534.KB906755_gene4015	3.09e-44	169.0	2E3FB@1|root,32YE4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_120	381666.H16_B0315	2.528e-21	94.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_4484073_146	1396141.BATP01000001_gene5389	0.0001032	45.0	COG0659@1|root,COG0659@2|Bacteria,46TUB@74201|Verrucomicrobia,2IVJF@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_4484073_135	1410619.SRDD_27860	1.744e-09	68.0	COG2067@1|root,COG2067@2|Bacteria,1RF1Y@1224|Proteobacteria,1T0CE@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_67	338966.Ppro_1648	6.16e-65	236.0	COG3115@1|root,COG3115@2|Bacteria,1QVM5@1224|Proteobacteria,43CDH@68525|delta/epsilon subdivisions,2X7PC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_4484073_8	381666.H16_B0315	2.743e-258	815.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_4484073_83	1267534.KB906755_gene4074	3.893e-53	194.0	COG2197@1|root,COG2197@2|Bacteria,3Y7QM@57723|Acidobacteria,2JMPR@204432|Acidobacteriia	204432|Acidobacteriia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4484073_27	1396418.BATQ01000120_gene3078	3.513e-146	484.0	COG4191@1|root,COG4191@2|Bacteria,46ZJR@74201|Verrucomicrobia,2IV4D@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3
HKD1_k127_4484073_68	1037409.BJ6T_24570	1.154e-64	228.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TRJB@28211|Alphaproteobacteria,3K5X9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4484073_115	1300345.LF41_2216	6.901e-28	119.0	COG4566@1|root,COG4566@2|Bacteria,1MZVZ@1224|Proteobacteria	1224|Proteobacteria	T	Pfam Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_4484073_9	1041139.KB902687_gene1250	3.808e-256	797.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,4B9EB@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Arylsulfatase	aslA	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD1_k127_4484073_43	215803.DB30_0910	5.274e-108	382.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,439X3@68525|delta/epsilon subdivisions,2WTWJ@28221|Deltaproteobacteria,2YY35@29|Myxococcales	28221|Deltaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_4484073_69	472759.Nhal_1551	5.077e-62	221.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,1S0TV@1236|Gammaproteobacteria,1WXDV@135613|Chromatiales	135613|Chromatiales	K	response regulator receiver	-	-	-	ko:K13041	ko02020,map02020	M00514	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD1_k127_4484073_117	1403819.BATR01000184_gene6388	4.645e-27	115.0	COG4566@1|root,COG4566@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD1_k127_4484073_50	1210884.HG799469_gene14130	5.75e-90	302.0	COG1611@1|root,COG1611@2|Bacteria,2J21H@203682|Planctomycetes	203682|Planctomycetes	S	Possible lysine decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	Lysine_decarbox
HKD1_k127_4484073_30	452637.Oter_0554	1.68e-139	457.0	COG1236@1|root,COG1236@2|Bacteria,46UFS@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD1_k127_4484073_1	886293.Sinac_2784	0.0	1394.0	COG3957@1|root,COG3957@2|Bacteria,2IWYJ@203682|Planctomycetes	203682|Planctomycetes	G	D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase	-	-	4.1.2.22,4.1.2.9	ko:K01621	ko00030,ko00710,ko01100,ko01120,map00030,map00710,map01100,map01120	-	R00761,R01621	RC00032,RC00226	ko00000,ko00001,ko01000	-	-	-	XFP,XFP_C,XFP_N
HKD1_k127_4484073_64	1304885.AUEY01000092_gene3645	1.005e-66	233.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,42MSW@68525|delta/epsilon subdivisions,2WNY3@28221|Deltaproteobacteria,2MJ39@213118|Desulfobacterales	28221|Deltaproteobacteria	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_4484073_96	1173024.KI912152_gene374	2.609e-42	158.0	2D8WY@1|root,32TS4@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_39	880072.Desac_2382	5.859e-121	399.0	COG0387@1|root,COG0387@2|Bacteria,1N1MR@1224|Proteobacteria,42MUQ@68525|delta/epsilon subdivisions	1224|Proteobacteria	P	Sodium calcium exchanger membrane	-	-	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	-	Na_Ca_ex
HKD1_k127_4484073_70	530564.Psta_2282	2.946e-61	222.0	2C3WA@1|root,2Z8P1@2|Bacteria,2J1GE@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_125	1121440.AUMA01000017_gene245	1.38e-18	91.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,42TSD@68525|delta/epsilon subdivisions,2WQ6E@28221|Deltaproteobacteria,2MCM3@213115|Desulfovibrionales	28221|Deltaproteobacteria	J	PFAM Endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD1_k127_4484073_38	315730.BcerKBAB4_0359	1.773e-122	407.0	COG2704@1|root,COG2704@2|Bacteria,1TR0A@1239|Firmicutes,4HE73@91061|Bacilli,1ZFEA@1386|Bacillus	91061|Bacilli	S	anaerobic c4-dicarboxylate	dcuB	-	-	ko:K07791,ko:K07792	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.13.1	-	-	DcuA_DcuB
HKD1_k127_4484073_22	1267533.KB906736_gene1283	2.717e-165	526.0	COG0252@1|root,COG0252@2|Bacteria,3Y8XT@57723|Acidobacteria	57723|Acidobacteria	EJ	Asparaginase	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase
HKD1_k127_4484073_45	1449049.JONW01000005_gene1181	1.809e-98	331.0	COG1180@1|root,COG1180@2|Bacteria,1NQC1@1224|Proteobacteria,2TV8Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	-	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_4484073_4	1449049.JONW01000005_gene1182	0.0	1269.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2TT7K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	formate C-acetyltransferase glycine radical	-	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_4484073_15	1267534.KB906761_gene1193	5.343e-201	633.0	COG0282@1|root,COG0282@2|Bacteria,3Y3Y4@57723|Acidobacteria,2JI6D@204432|Acidobacteriia	57723|Acidobacteria	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD1_k127_4484073_21	1449049.JONW01000005_gene1183	2.318e-165	529.0	COG2271@1|root,COG2271@2|Bacteria,1RGKJ@1224|Proteobacteria,2TV2F@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4484073_16	234267.Acid_2326	9.321e-201	640.0	COG3170@1|root,COG3170@2|Bacteria,3Y9A5@57723|Acidobacteria	2|Bacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6
HKD1_k127_4484073_11	234267.Acid_4974	3.37e-252	788.0	COG1760@1|root,COG1760@2|Bacteria,3Y420@57723|Acidobacteria	57723|Acidobacteria	E	serine dehydratase beta chain	-	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha,SDH_beta
HKD1_k127_4484073_10	1267533.KB906736_gene1282	1.265e-253	789.0	COG1027@1|root,COG1027@2|Bacteria,3Y3XS@57723|Acidobacteria,2JHYF@204432|Acidobacteriia	57723|Acidobacteria	E	Fumarase C C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	FumaraseC_C,Lyase_1
HKD1_k127_4484073_40	1267533.KB906738_gene2209	3.256e-119	391.0	COG4786@1|root,COG4786@2|Bacteria,3Y41A@57723|Acidobacteria,2JM5Y@204432|Acidobacteriia	204432|Acidobacteriia	N	Protein of unknown function (DUF2950)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2950
HKD1_k127_4484073_35	204669.Acid345_4077	1.595e-125	419.0	COG3064@1|root,COG3064@2|Bacteria,3Y7SB@57723|Acidobacteria,2JN3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_4484073_34	204669.Acid345_0403	1.517e-129	433.0	COG3064@1|root,COG3064@2|Bacteria,3Y6QP@57723|Acidobacteria,2JMDE@204432|Acidobacteriia	204432|Acidobacteriia	M	Protein of unknown function (DUF3300)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3300
HKD1_k127_4484073_23	1267533.KB906738_gene2199	1.66e-162	525.0	COG2911@1|root,COG2911@2|Bacteria,3Y89W@57723|Acidobacteria	57723|Acidobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4484073_99	1267534.KB906754_gene3072	1.493e-41	161.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria,2JHY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4484073_62	1454004.AW11_02393	5.3e-67	240.0	COG4313@1|root,COG4313@2|Bacteria,1PRCN@1224|Proteobacteria,2VQHT@28216|Betaproteobacteria,1KQK1@119066|unclassified Betaproteobacteria	28216|Betaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD1_k127_4484073_76	1211777.BN77_p11370	4.719e-59	213.0	2C2X7@1|root,2ZFQR@2|Bacteria,1R940@1224|Proteobacteria,2U3U6@28211|Alphaproteobacteria,4BP4T@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD1_k127_4484073_88	1267534.KB906754_gene2615	8.25e-51	186.0	2C852@1|root,32YB2@2|Bacteria,3Y55S@57723|Acidobacteria,2JJNG@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD1_k127_4484073_63	1123242.JH636436_gene123	5.349e-67	241.0	COG0631@1|root,COG0631@2|Bacteria,2IZVG@203682|Planctomycetes	203682|Planctomycetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K01090,ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD1_k127_4484073_82	574087.Acear_0306	2.081e-53	198.0	COG1940@1|root,COG1940@2|Bacteria,1TPKW@1239|Firmicutes,248U9@186801|Clostridia,3WB29@53433|Halanaerobiales	186801|Clostridia	GK	TIGRFAM ROK family protein	glcK	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10220	ROK
HKD1_k127_4502552_0	234267.Acid_1953	0.0	1364.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4502552_5	760192.Halhy_2292	1.676e-95	334.0	COG0308@1|root,COG0308@2|Bacteria,4NG5Q@976|Bacteroidetes,1IRN9@117747|Sphingobacteriia	976|Bacteroidetes	M	PFAM Peptidase M1 membrane alanine aminopeptidase	-	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,Peptidase_M1
HKD1_k127_4502552_20	1089550.ATTH01000001_gene1606	3.843e-10	68.0	COG0484@1|root,COG0484@2|Bacteria,4NE4X@976|Bacteroidetes,1FIS6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	O	DnaJ molecular chaperone homology domain	dnaJ2	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_4502552_19	562970.Btus_2311	4.01e-11	68.0	COG0346@1|root,COG0346@2|Bacteria,1VNT0@1239|Firmicutes	1239|Firmicutes	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4502552_1	1128421.JAGA01000002_gene269	3.833e-214	682.0	COG0531@1|root,COG0531@2|Bacteria,2NNZQ@2323|unclassified Bacteria	2|Bacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_4502552_13	204669.Acid345_1209	1.302e-28	119.0	2DIW1@1|root,32UBV@2|Bacteria,3Y5BC@57723|Acidobacteria,2JJSS@204432|Acidobacteriia	204432|Acidobacteriia	S	Probable zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zf-trcl
HKD1_k127_4502552_4	588581.Cpap_0931	5.575e-120	399.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,3WGPD@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_4502552_10	378806.STAUR_6365	7.779e-40	157.0	COG1842@1|root,COG1842@2|Bacteria,1NNUD@1224|Proteobacteria,438WP@68525|delta/epsilon subdivisions,2X9RW@28221|Deltaproteobacteria,2YY15@29|Myxococcales	28221|Deltaproteobacteria	KT	PspA/IM30 family	-	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD1_k127_4502552_15	1278073.MYSTI_06291	6.228e-20	100.0	2EDTI@1|root,337NU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4502552_3	428125.CLOLEP_00746	2.592e-139	475.0	COG0209@1|root,COG0209@2|Bacteria,1TPFH@1239|Firmicutes,249EN@186801|Clostridia,3WGZ6@541000|Ruminococcaceae	186801|Clostridia	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Intein_splicing,LAGLIDADG_3,Ribonuc_red_2_N,Ribonuc_red_lgC,Ribonuc_red_lgN,TSCPD
HKD1_k127_4502552_2	1163407.UU7_13758	5.23e-200	631.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Kelch_1,NPCBM,SpoIIE
HKD1_k127_4502552_22	1048983.EL17_23145	5.188e-05	48.0	COG1943@1|root,COG1943@2|Bacteria,4NPPG@976|Bacteroidetes,47RSC@768503|Cytophagia	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_4502552_17	1121373.KB903623_gene2281	9.663e-16	79.0	COG1943@1|root,COG1943@2|Bacteria,4NPPG@976|Bacteroidetes,47RSC@768503|Cytophagia	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_4502552_16	402777.KB235903_gene1611	1.036e-17	96.0	COG0666@1|root,COG0666@2|Bacteria,1G0E1@1117|Cyanobacteria,1H7BV@1150|Oscillatoriales	1117|Cyanobacteria	S	COG0666 FOG Ankyrin repeat	ank	-	-	ko:K06867	-	-	-	-	ko00000	-	-	-	Ank,Ank_2,Ank_3,Ank_4,Ank_5
HKD1_k127_4502552_14	204669.Acid345_4011	8.992e-28	117.0	2ED19@1|root,336Y7@2|Bacteria,3Y95N@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4502552_11	1032480.MLP_10410	1.119e-29	123.0	2F0R3@1|root,33TTH@2|Bacteria,2H4R6@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4502552_9	211165.AJLN01000084_gene1825	2.817e-48	185.0	COG5640@1|root,COG5640@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin
HKD1_k127_4502552_12	335543.Sfum_0084	4.411e-29	118.0	COG0724@1|root,COG0724@2|Bacteria,1N6VR@1224|Proteobacteria,42UQP@68525|delta/epsilon subdivisions,2WQKU@28221|Deltaproteobacteria,2MS96@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	RNA recognition motif	-	-	-	-	-	-	-	-	-	-	-	-	RRM_1
HKD1_k127_4502552_18	485915.Dret_0882	9.485e-12	69.0	2DD8W@1|root,2ZH3F@2|Bacteria,1PBGJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4502552_21	485915.Dret_0882	2.594e-08	57.0	2DD8W@1|root,2ZH3F@2|Bacteria,1PBGJ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4502552_7	1304872.JAGC01000005_gene1959	4.984e-50	181.0	COG3344@1|root,COG3344@2|Bacteria,1MVI1@1224|Proteobacteria,42Q0C@68525|delta/epsilon subdivisions,2WIIZ@28221|Deltaproteobacteria,2MDPJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	L	PFAM RNA-directed DNA polymerase (Reverse transcriptase)	-	-	2.7.7.49	ko:K00986,ko:K15342	-	-	-	-	ko00000,ko01000,ko02048,ko03400	-	-	-	Cas_Cas1,GIIM,RVT_1
HKD1_k127_4502552_8	1121405.dsmv_1643	4.773e-49	179.0	COG1764@1|root,COG1764@2|Bacteria,1RH9U@1224|Proteobacteria,42TWN@68525|delta/epsilon subdivisions,2WQDD@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	OsmC-like protein	osmC	-	-	ko:K04063	-	-	-	-	ko00000	-	-	-	OsmC
HKD1_k127_4502552_6	1123278.KB893563_gene4528	5.919e-58	207.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,47PPC@768503|Cytophagia	976|Bacteroidetes	O	Conserved domain frequently associated with peptide methionine sulfoxide reductase	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD1_k127_4527045_0	1382359.JIAL01000001_gene1531	0.0	1464.0	COG0383@1|root,COG0383@2|Bacteria,3Y2RJ@57723|Acidobacteria,2JI5W@204432|Acidobacteriia	204432|Acidobacteriia	G	glycoside hydrolase family 38	-	-	3.2.1.24	ko:K01191	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04131	-	GH38	-	Alpha-mann_mid,Glyco_hydro_38,Glyco_hydro_38C
HKD1_k127_4527045_2	1267535.KB906767_gene3249	1.113e-196	629.0	COG5434@1|root,COG5434@2|Bacteria,3Y2SR@57723|Acidobacteria,2JIUJ@204432|Acidobacteriia	204432|Acidobacteriia	M	Right handed beta helix region	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Pectate_lyase_3
HKD1_k127_4527045_1	999419.HMPREF1077_02043	7.07e-322	1004.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	F5_F8_type_C,Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_4527045_3	1185876.BN8_00463	6.315e-106	355.0	2DB8U@1|root,2Z7SW@2|Bacteria,4NEUK@976|Bacteroidetes,47KH1@768503|Cytophagia	976|Bacteroidetes	S	Alginate lyase	-	-	-	-	-	-	-	-	-	-	-	-	Alginate_lyase
HKD1_k127_4570325_10	204669.Acid345_4420	1.509e-25	107.0	COG1266@1|root,COG1266@2|Bacteria	2|Bacteria	V	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_4570325_5	1297569.MESS2_410026	1.344e-60	213.0	2C4SR@1|root,32TC7@2|Bacteria,1RCZG@1224|Proteobacteria,2U89H@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4570325_9	497964.CfE428DRAFT_6548	7.73e-47	173.0	2EH8A@1|root,33B04@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4570325_7	1248916.ANFY01000010_gene419	2.411e-52	187.0	COG1917@1|root,COG1917@2|Bacteria,1RHHY@1224|Proteobacteria,2UCCW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_3
HKD1_k127_4570325_14	706436.HMPREF9074_07560	0.0001287	54.0	COG3577@1|root,COG3577@2|Bacteria,4NNI0@976|Bacteroidetes,1I1Z6@117743|Flavobacteriia,1ES2Q@1016|Capnocytophaga	976|Bacteroidetes	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD1_k127_4570325_12	1004149.AFOE01000012_gene1511	2.956e-08	66.0	COG3577@1|root,COG3577@2|Bacteria,4NNI0@976|Bacteroidetes,1I1Z6@117743|Flavobacteriia	976|Bacteroidetes	S	protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2
HKD1_k127_4570325_8	330214.NIDE3531	5.233e-49	188.0	COG0583@1|root,COG0583@2|Bacteria,3J16P@40117|Nitrospirae	40117|Nitrospirae	K	Transcriptional regulator	-	-	-	ko:K11921,ko:K19338	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4570325_1	497964.CfE428DRAFT_5676	2.551e-146	474.0	COG0715@1|root,COG0715@2|Bacteria,46UC9@74201|Verrucomicrobia	74201|Verrucomicrobia	P	NMT1/THI5 like	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD1_k127_4570325_2	497964.CfE428DRAFT_5677	3.767e-133	432.0	COG0600@1|root,COG0600@2|Bacteria,46TTV@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_4570325_3	497964.CfE428DRAFT_5678	6.34e-115	378.0	COG1116@1|root,COG1116@2|Bacteria,46UXE@74201|Verrucomicrobia	74201|Verrucomicrobia	P	ATPases associated with a variety of cellular activities	-	-	-	ko:K15555	ko00920,ko02010,map00920,map02010	M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.17.2	-	-	ABC_tran
HKD1_k127_4570325_0	1496688.ER33_07135	4.365e-280	884.0	COG3119@1|root,COG3119@2|Bacteria,1G22U@1117|Cyanobacteria,22RRC@167375|Cyanobium	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD1_k127_4570325_4	1094508.Tsac_0117	2.524e-94	326.0	COG0531@1|root,COG0531@2|Bacteria,1TRFS@1239|Firmicutes,248WW@186801|Clostridia,42HP7@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM Amino acid	-	-	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	-	AA_permease_2
HKD1_k127_4570325_13	1268622.AVS7_00299	3.448e-07	64.0	2BW81@1|root,32UWZ@2|Bacteria,1MZGZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4570325_11	497964.CfE428DRAFT_6679	1.419e-12	70.0	COG1758@1|root,COG1758@2|Bacteria,46T94@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	-	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_4570325_6	497964.CfE428DRAFT_6017	7.637e-58	208.0	COG1432@1|root,COG1432@2|Bacteria	2|Bacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	CSD,NYN
HKD1_k127_4593831_2	234267.Acid_7688	4.158e-39	150.0	COG1277@1|root,COG1277@2|Bacteria,3Y839@57723|Acidobacteria	57723|Acidobacteria	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HKD1_k127_4593831_1	234267.Acid_7689	3.227e-129	420.0	COG1131@1|root,COG1131@2|Bacteria,3Y6U6@57723|Acidobacteria	57723|Acidobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4593831_0	234267.Acid_7690	2.21e-134	462.0	COG3712@1|root,COG3712@2|Bacteria,3Y772@57723|Acidobacteria	57723|Acidobacteria	PT	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD1_k127_4593831_3	234267.Acid_7691	2.363e-33	138.0	COG1595@1|root,COG1595@2|Bacteria,3Y8Q7@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4593831_5	118168.MC7420_1914	2.405e-16	88.0	2DRBA@1|root,33B2N@2|Bacteria,1GAYX@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4593831_4	1267533.KB906736_gene1247	9.878e-23	102.0	COG0346@1|root,COG0346@2|Bacteria,3Y8C4@57723|Acidobacteria	57723|Acidobacteria	E	Glyoxalase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_4599029_26	234267.Acid_0278	2.203e-36	160.0	2F9MS@1|root,341XZ@2|Bacteria,3Y8CW@57723|Acidobacteria	234267.Acid_0278|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4599029_37	509635.N824_20125	5.754e-11	76.0	COG3408@1|root,COG3408@2|Bacteria,4NHST@976|Bacteroidetes,1INMP@117747|Sphingobacteriia	976|Bacteroidetes	G	Alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C
HKD1_k127_4599029_41	765913.ThidrDRAFT_3930	1.093e-08	69.0	COG2340@1|root,COG2373@1|root,COG2931@1|root,COG4547@1|root,COG4625@1|root,COG5492@1|root,COG2340@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG4547@2|Bacteria,COG4625@2|Bacteria,COG5492@2|Bacteria,1MU7T@1224|Proteobacteria,1S1HJ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	COG2931, RTX toxins and related Ca2 -binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cadherin_3,DUF4214,DUF4347,He_PIG,HemolysinCabind,PATR,VCBS
HKD1_k127_4599029_15	1125863.JAFN01000001_gene383	3.436e-65	237.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,42R3N@68525|delta/epsilon subdivisions,2WMY8@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	eight transmembrane protein EpsH	epsH	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
HKD1_k127_4599029_27	1499967.BAYZ01000118_gene3288	2.611e-34	140.0	COG1269@1|root,COG1269@2|Bacteria	2|Bacteria	C	ATP hydrolysis coupled proton transport	ntpI	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	DUF3485,V_ATPase_I
HKD1_k127_4599029_12	401053.AciPR4_0590	1.836e-80	297.0	COG0457@1|root,COG0457@2|Bacteria,3Y6J0@57723|Acidobacteria,2JKHK@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8
HKD1_k127_4599029_23	278963.ATWD01000001_gene2188	1.488e-41	173.0	COG3206@1|root,COG3206@2|Bacteria,3Y3JI@57723|Acidobacteria,2JI13@204432|Acidobacteriia	204432|Acidobacteriia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HKD1_k127_4599029_17	1232410.KI421418_gene2400	5.829e-64	231.0	COG3267@1|root,COG3267@2|Bacteria,1MU3G@1224|Proteobacteria,42NNX@68525|delta/epsilon subdivisions,2WJ9P@28221|Deltaproteobacteria,43TQ5@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	AAA domain	-	-	-	ko:K02450	-	M00331	-	-	ko00000,ko00002,ko02044	9.B.42	-	-	AAA_22
HKD1_k127_4599029_25	1125863.JAFN01000001_gene472	1.475e-37	155.0	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,42QS3@68525|delta/epsilon subdivisions,2WMX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Capsular exopolysaccharide family	-	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA,ParA
HKD1_k127_4599029_6	1125863.JAFN01000001_gene473	1.054e-117	394.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD1_k127_4599029_34	1454004.AW11_03534	3.364e-13	80.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,2VPSB@28216|Betaproteobacteria	28216|Betaproteobacteria	M	polysaccharide export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_4599029_19	1123367.C666_03655	6.962e-50	194.0	COG4447@1|root,COG4447@2|Bacteria,1RCCJ@1224|Proteobacteria,2VJGM@28216|Betaproteobacteria,2KVJ7@206389|Rhodocyclales	206389|Rhodocyclales	S	Photosynthesis system II assembly factor YCF48	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HKD1_k127_4599029_40	383381.EH30_12600	4.375e-09	69.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,2K1FV@204457|Sphingomonadales	204457|Sphingomonadales	O	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_11,TPR_16,TPR_2,TPR_6,TPR_8
HKD1_k127_4599029_11	177437.HRM2_22640	4.286e-82	302.0	COG0457@1|root,COG3063@1|root,COG0457@2|Bacteria,COG3063@2|Bacteria,1MXMD@1224|Proteobacteria,42NZK@68525|delta/epsilon subdivisions,2WIY5@28221|Deltaproteobacteria,2MJAV@213118|Desulfobacterales	28221|Deltaproteobacteria	O	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_14,TPR_16,TPR_19,TPR_2,TPR_6,TPR_8,zinc_ribbon_4
HKD1_k127_4599029_22	1125863.JAFN01000001_gene622	4.803e-42	173.0	COG3206@1|root,COG3206@2|Bacteria,1MVBX@1224|Proteobacteria,42M2D@68525|delta/epsilon subdivisions,2WJU6@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipopolysaccharide biosynthesis protein	wzc1	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HKD1_k127_4599029_16	1267535.KB906767_gene1027	1.513e-64	235.0	COG3267@1|root,COG3267@2|Bacteria,3Y6KP@57723|Acidobacteria	57723|Acidobacteria	U	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_22
HKD1_k127_4599029_24	1125863.JAFN01000001_gene472	1.183e-38	158.0	COG0489@1|root,COG0489@2|Bacteria,1MVI9@1224|Proteobacteria,42QS3@68525|delta/epsilon subdivisions,2WMX0@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	Capsular exopolysaccharide family	-	-	2.7.10.1	ko:K08252	-	-	-	-	ko00000,ko01000	-	-	-	AAA_31,CbiA,ParA
HKD1_k127_4599029_7	1125863.JAFN01000001_gene473	7.763e-111	374.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42NH8@68525|delta/epsilon subdivisions,2WJMA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD1_k127_4599029_33	1408418.JNJH01000039_gene1139	3.137e-14	83.0	COG1596@1|root,COG1596@2|Bacteria,1RFBH@1224|Proteobacteria,2U835@28211|Alphaproteobacteria,2JS6A@204441|Rhodospirillales	204441|Rhodospirillales	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_4599029_42	1089547.KB913013_gene2026	6.187e-06	53.0	COG4447@1|root,COG4447@2|Bacteria,4NGUK@976|Bacteroidetes,47NCA@768503|Cytophagia	976|Bacteroidetes	S	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	BNR,PSII_BNR,Sortilin-Vps10
HKD1_k127_4599029_38	446468.Ndas_1757	1.348e-09	65.0	2BNAB@1|root,32GXX@2|Bacteria,2HF1P@201174|Actinobacteria,4EPYI@85012|Streptosporangiales	201174|Actinobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_4599029_43	1340493.JNIF01000003_gene3542	3.883e-05	53.0	2C9TJ@1|root,2ZFZD@2|Bacteria,3Y970@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4599029_4	1382359.JIAL01000001_gene2242	1.182e-144	477.0	COG1190@1|root,COG1190@2|Bacteria,3Y3N0@57723|Acidobacteria,2JI1W@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_4599029_18	1125863.JAFN01000001_gene3040	1.663e-50	184.0	COG0615@1|root,COG0615@2|Bacteria,1REW3@1224|Proteobacteria,42SGQ@68525|delta/epsilon subdivisions,2WPTP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose	rfaE	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD1_k127_4599029_0	204669.Acid345_4549	3.917e-305	977.0	COG1197@1|root,COG1197@2|Bacteria,3Y3IE@57723|Acidobacteria,2JIHQ@204432|Acidobacteriia	204432|Acidobacteriia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_4599029_28	926566.Terro_0747	1.682e-32	141.0	COG0760@1|root,COG0760@2|Bacteria,3Y3V9@57723|Acidobacteria,2JICA@204432|Acidobacteriia	204432|Acidobacteriia	O	Peptidylprolyl isomerase	-	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N,SurA_N_3
HKD1_k127_4599029_31	648996.Theam_1264	1.156e-16	85.0	COG1188@1|root,COG1188@2|Bacteria,2G57F@200783|Aquificae	200783|Aquificae	J	RNA-binding S4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	S4
HKD1_k127_4599029_36	1198114.AciX9_0202	1.654e-12	78.0	COG0366@1|root,COG0810@1|root,COG0366@2|Bacteria,COG0810@2|Bacteria,3Y3UM@57723|Acidobacteria,2JHQB@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-amylase domain	-	-	3.2.1.10	ko:K01182	ko00052,ko00500,ko01100,map00052,map00500,map01100	-	R00801,R01718,R01791,R06199	RC00028,RC00059,RC00077,RC00451	ko00000,ko00001,ko01000	-	GH13	-	Alpha-amylase,Malt_amylase_C
HKD1_k127_4599029_20	335543.Sfum_3514	5.39e-47	177.0	COG3034@1|root,COG3034@2|Bacteria,1QTMV@1224|Proteobacteria,42W1K@68525|delta/epsilon subdivisions,2X5QE@28221|Deltaproteobacteria,2MS74@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_4599029_14	330214.NIDE1013	3.168e-77	271.0	COG1077@1|root,COG1077@2|Bacteria,3J0BS@40117|Nitrospirae	40117|Nitrospirae	D	Actin	-	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_4599029_9	1128421.JAGA01000003_gene3582	1.516e-90	310.0	COG0042@1|root,COG0042@2|Bacteria,2NP3E@2323|unclassified Bacteria	2|Bacteria	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_4599029_39	929712.KI912613_gene1015	3.174e-09	69.0	COG1376@1|root,COG1376@2|Bacteria,2HNXN@201174|Actinobacteria,4CQ6A@84995|Rubrobacteria	84995|Rubrobacteria	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
HKD1_k127_4599029_3	1267535.KB906767_gene3116	9.521e-188	600.0	COG0531@1|root,COG0531@2|Bacteria,3Y3QM@57723|Acidobacteria,2JKYS@204432|Acidobacteriia	204432|Acidobacteriia	E	Amino acid permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_4599029_1	194439.CT0923	3.489e-221	697.0	COG0531@1|root,COG0531@2|Bacteria,1FECX@1090|Chlorobi	1090|Chlorobi	E	C-terminus of AA_permease	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_4599029_10	240015.ACP_1051	3.048e-90	310.0	COG3437@1|root,COG3437@2|Bacteria,3Y2TI@57723|Acidobacteria,2JHKC@204432|Acidobacteriia	204432|Acidobacteriia	T	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD_5,Response_reg
HKD1_k127_4599029_35	204669.Acid345_2505	1.429e-12	79.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_4599029_8	903818.KI912268_gene1631	1.623e-106	356.0	COG0280@1|root,COG0280@2|Bacteria,3Y6AD@57723|Acidobacteria	57723|Acidobacteria	C	Phosphate acetyl/butaryl transferase	-	-	2.3.1.8	ko:K00625	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	PTA_PTB
HKD1_k127_4599029_2	1123277.KB893172_gene921	4.148e-195	630.0	COG0457@1|root,COG1680@1|root,COG0457@2|Bacteria,COG1680@2|Bacteria,4NI1Z@976|Bacteroidetes,47Q5S@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471,TPR_2,TPR_8
HKD1_k127_4599029_29	1123371.ATXH01000022_gene961	1.583e-23	107.0	COG3339@1|root,COG3339@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD1_k127_4599029_21	402777.KB235904_gene4022	6.124e-46	173.0	COG4636@1|root,COG4636@2|Bacteria,1G269@1117|Cyanobacteria,1HATJ@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_4599029_5	234267.Acid_3614	4.087e-132	431.0	COG1060@1|root,COG1060@2|Bacteria,3Y2IA@57723|Acidobacteria	57723|Acidobacteria	H	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	1.21.98.1	ko:K11784	ko00130,ko01110,map00130,map01110	-	R08588	RC02329	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD1_k127_4599029_13	479434.Sthe_0108	3.49e-79	275.0	COG2159@1|root,COG2159@2|Bacteria,2G8UX@200795|Chloroflexi,27Z57@189775|Thermomicrobia	189775|Thermomicrobia	S	Amidohydrolase	-	-	4.1.1.45	ko:K03392	ko00380,ko01100,map00380,map01100	M00038	R04323	RC00779	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_2
HKD1_k127_4599029_30	344747.PM8797T_04845	1.224e-22	109.0	COG4886@1|root,COG4886@2|Bacteria	2|Bacteria	S	regulation of response to stimulus	-	-	-	-	-	-	-	-	-	-	-	-	LRR_6
HKD1_k127_4599029_32	485913.Krac_8189	1.395e-15	78.0	COG2848@1|root,COG2848@2|Bacteria,2G6HQ@200795|Chloroflexi	200795|Chloroflexi	S	Uncharacterised ACR (DUF711)	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
HKD1_k127_4698315_6	1183438.GKIL_3396	2.041e-58	209.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_4698315_1	204669.Acid345_1052	4.044e-177	586.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_4698315_4	886293.Sinac_4633	1.613e-99	344.0	COG1680@1|root,COG1680@2|Bacteria,2J0ZW@203682|Planctomycetes	203682|Planctomycetes	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_4698315_0	309807.SRU_0691	6.906e-258	818.0	COG0460@1|root,COG0527@1|root,COG0460@2|Bacteria,COG0527@2|Bacteria,4NFGR@976|Bacteroidetes,1FIND@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	E	homoserine dehydrogenase	-	-	1.1.1.3,2.7.2.4	ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT_7,Homoserine_dh,NAD_binding_3
HKD1_k127_4698315_5	1034943.BN1094_00247	1.771e-80	280.0	COG0083@1|root,COG0083@2|Bacteria,1MW8I@1224|Proteobacteria,1RMYR@1236|Gammaproteobacteria,1JCVP@118969|Legionellales	118969|Legionellales	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	-	-	-	-	-	-	-	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_4698315_3	158190.SpiGrapes_0038	5.678e-131	430.0	COG0498@1|root,COG0498@2|Bacteria,2J63T@203691|Spirochaetes	203691|Spirochaetes	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD1_k127_4698315_2	1469607.KK073768_gene900	1.826e-150	511.0	COG0642@1|root,COG0745@1|root,COG0784@1|root,COG4251@1|root,COG0745@2|Bacteria,COG0784@2|Bacteria,COG2205@2|Bacteria,COG4251@2|Bacteria,1G09B@1117|Cyanobacteria,1HIE5@1161|Nostocales	1117|Cyanobacteria	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_4698315_8	292459.STH1184	5.706e-10	65.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria,1VNAP@1239|Firmicutes,24W68@186801|Clostridia	186801|Clostridia	S	Pkd domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
HKD1_k127_4698315_7	4792.ETI56840	7.854e-18	96.0	2CMU2@1|root,2QRYI@2759|Eukaryota,3QARG@4776|Peronosporales	4776|Peronosporales	K	DEK C terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	DEK_C,Med26
HKD1_k127_4782081_21	401053.AciPR4_3082	5.112e-06	59.0	COG4932@1|root,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_4782081_4	1379270.AUXF01000002_gene1394	9.433e-119	399.0	COG0612@1|root,COG0612@2|Bacteria,1ZT1J@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4782081_7	861299.J421_1261	2.271e-94	326.0	COG0612@1|root,COG0612@2|Bacteria,1ZT7N@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16_C
HKD1_k127_4782081_19	1443665.JACA01000007_gene236	7.401e-15	79.0	2FIGE@1|root,34A8I@2|Bacteria,4P5ED@976|Bacteroidetes,1IA7C@117743|Flavobacteriia,2YJMD@290174|Aquimarina	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4782081_14	1267535.KB906767_gene4156	3.671e-42	163.0	COG0461@1|root,COG0461@2|Bacteria,3Y6JQ@57723|Acidobacteria	57723|Acidobacteria	F	Phosphoribosyl transferase domain	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_4782081_18	1394178.AWOO02000012_gene3828	2.903e-18	91.0	COG1051@1|root,COG1051@2|Bacteria,2IIJJ@201174|Actinobacteria,4EJRA@85012|Streptosporangiales	201174|Actinobacteria	F	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_4782081_22	491205.JARQ01000002_gene107	2.868e-05	47.0	COG1943@1|root,COG1943@2|Bacteria,4NNQJ@976|Bacteroidetes,1I8RN@117743|Flavobacteriia,3ZRXE@59732|Chryseobacterium	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_4782081_15	661478.OP10G_1460	1.076e-32	131.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_4782081_9	204669.Acid345_2431	1.81e-81	284.0	COG2605@1|root,COG2605@2|Bacteria,3Y56A@57723|Acidobacteria,2JP24@204432|Acidobacteriia	204432|Acidobacteriia	S	GHMP kinases C terminal	-	-	2.7.1.168	ko:K07031	ko00540,map00540	-	R09770	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_4782081_23	326424.FRAAL4823	9.136e-05	53.0	COG0586@1|root,COG0586@2|Bacteria,2GN4A@201174|Actinobacteria,4EWQF@85013|Frankiales	201174|Actinobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_4782081_17	247490.KSU1_D0145	1.663e-22	103.0	COG0589@1|root,COG0589@2|Bacteria,2J0XB@203682|Planctomycetes	203682|Planctomycetes	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4782081_13	42256.RradSPS_3047	2.031e-52	197.0	COG1940@1|root,COG1940@2|Bacteria,2GJCQ@201174|Actinobacteria,4CPVZ@84995|Rubrobacteria	84995|Rubrobacteria	GK	ROK family	-	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	ROK
HKD1_k127_4782081_12	1340493.JNIF01000003_gene3786	1.693e-52	190.0	COG0041@1|root,COG0041@2|Bacteria,3Y4MB@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_4782081_0	1267535.KB906767_gene2200	1.242e-230	723.0	COG0473@1|root,COG0473@2|Bacteria,3Y3BC@57723|Acidobacteria,2JKC7@204432|Acidobacteriia	204432|Acidobacteriia	C	Isocitrate/isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_4782081_2	204669.Acid345_4299	1.392e-153	518.0	COG1193@1|root,COG1193@2|Bacteria,3Y2Z2@57723|Acidobacteria,2JHU4@204432|Acidobacteriia	204432|Acidobacteriia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD1_k127_4782081_5	477974.Daud_0491	2.617e-102	355.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,2600X@186807|Peptococcaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD1_k127_4782081_1	234267.Acid_1008	1.044e-162	531.0	COG0568@1|root,COG0568@2|Bacteria,3Y2XG@57723|Acidobacteria	57723|Acidobacteria	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_4782081_3	1121405.dsmv_3401	7.507e-134	450.0	COG1032@1|root,COG1032@2|Bacteria,1MU15@1224|Proteobacteria,42N12@68525|delta/epsilon subdivisions,2WK0X@28221|Deltaproteobacteria,2MI8S@213118|Desulfobacterales	28221|Deltaproteobacteria	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_4782081_10	1173026.Glo7428_0587	4.648e-79	277.0	COG0337@1|root,COG0337@2|Bacteria,1G03C@1117|Cyanobacteria	1117|Cyanobacteria	E	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)	aroB	-	4.2.3.4	ko:K01735	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03083	RC00847	ko00000,ko00001,ko00002,ko01000	-	-	-	DHQ_synthase
HKD1_k127_4782081_6	1356852.N008_05325	3.145e-97	355.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,4NK8Q@976|Bacteroidetes,47KVN@768503|Cytophagia	976|Bacteroidetes	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HKD1_k127_4782081_11	945713.IALB_2758	7.704e-61	218.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4782081_16	1408433.JHXV01000005_gene2292	2.396e-23	113.0	COG2746@1|root,COG2746@2|Bacteria,4NWN7@976|Bacteroidetes,1I525@117743|Flavobacteriia,2PBE1@246874|Cryomorphaceae	976|Bacteroidetes	V	Aminoglycoside 3-N-acetyltransferase	-	-	2.3.1.81	ko:K00662	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Antibiotic_NAT
HKD1_k127_4782081_20	756067.MicvaDRAFT_5451	6.541e-09	62.0	COG1361@1|root,COG2931@1|root,COG3210@1|root,COG4932@1|root,COG1361@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,COG4932@2|Bacteria,1G463@1117|Cyanobacteria,1H97Y@1150|Oscillatoriales	1117|Cyanobacteria	MQ	PFAM Collagen-binding surface protein Cna-like, B-type domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4347,HemolysinCabind,SdrD_B
HKD1_k127_4782081_8	1147.D082_25660	8.934e-87	317.0	COG2931@1|root,COG3204@1|root,COG3210@1|root,COG5184@1|root,COG2931@2|Bacteria,COG3204@2|Bacteria,COG3210@2|Bacteria,COG5184@2|Bacteria,1G5KY@1117|Cyanobacteria,1H6DE@1142|Synechocystis	1117|Cyanobacteria	QU	Cadherin repeats.	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Calx-beta,HemolysinCabind,VCBS
HKD1_k127_4788861_8	1267535.KB906767_gene4366	2.38e-121	429.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WQ@57723|Acidobacteria,2JICR@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_4788861_14	234267.Acid_2678	2.399e-63	233.0	COG1940@1|root,COG1940@2|Bacteria,3Y3B2@57723|Acidobacteria	57723|Acidobacteria	GK	PFAM ROK family	-	-	-	-	-	-	-	-	-	-	-	-	ROK
HKD1_k127_4788861_2	1408473.JHXO01000008_gene2709	0.0	1043.0	COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,2FPM1@200643|Bacteroidia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	bga	GO:0000272,GO:0003674,GO:0003824,GO:0004553,GO:0004565,GO:0005975,GO:0005976,GO:0006073,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0010383,GO:0010410,GO:0010411,GO:0015925,GO:0016052,GO:0016787,GO:0016798,GO:0043170,GO:0044036,GO:0044042,GO:0044237,GO:0044238,GO:0044260,GO:0044262,GO:0044264,GO:0044403,GO:0044419,GO:0051704,GO:0071554,GO:0071704,GO:0085030,GO:1901575,GO:2000895,GO:2000899	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_4788861_9	316274.Haur_1902	2.974e-118	392.0	COG2730@1|root,COG2730@2|Bacteria,2G9AS@200795|Chloroflexi,3764N@32061|Chloroflexia	32061|Chloroflexia	G	Belongs to the glycosyl hydrolase 5 (cellulase A) family	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Cellulase
HKD1_k127_4788861_6	717605.Theco_0557	1.166e-246	792.0	COG3250@1|root,COG3250@2|Bacteria,1TS96@1239|Firmicutes,4HBKW@91061|Bacilli,26S7W@186822|Paenibacillaceae	91061|Bacilli	G	Belongs to the glycosyl hydrolase 2 family	bmnA	-	3.2.1.25	ko:K01192	ko00511,ko04142,map00511,map04142	-	-	-	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_4788861_17	745776.DGo_CA0722	2.839e-21	103.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	CBM_2,Glyco_hydro_26
HKD1_k127_4788861_11	1382359.JIAL01000001_gene444	3.632e-93	318.0	COG2021@1|root,COG2021@2|Bacteria,3Y4JM@57723|Acidobacteria,2JJBE@204432|Acidobacteriia	204432|Acidobacteriia	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_4788861_10	639030.JHVA01000001_gene1755	4.692e-102	340.0	COG2273@1|root,COG2273@2|Bacteria,3Y4BI@57723|Acidobacteria,2JJ7F@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolases family 16	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
HKD1_k127_4788861_13	1267211.KI669560_gene1242	1.32e-80	276.0	COG1073@1|root,COG1073@2|Bacteria,4PN7H@976|Bacteroidetes,1J0MK@117747|Sphingobacteriia	976|Bacteroidetes	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD1_k127_4788861_3	1121957.ATVL01000008_gene4409	3.483e-305	954.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,47UBJ@768503|Cytophagia	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_4788861_0	639030.JHVA01000001_gene2512	0.0	1491.0	COG1629@1|root,COG4771@2|Bacteria,3Y6MN@57723|Acidobacteria	57723|Acidobacteria	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_4788861_12	1382359.JIAL01000001_gene1849	5.072e-81	274.0	COG2197@1|root,COG2197@2|Bacteria,3Y4DR@57723|Acidobacteria,2JJ2N@204432|Acidobacteriia	204432|Acidobacteriia	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_4788861_5	1382359.JIAL01000001_gene1848	6.639e-267	857.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria,3Y2ZI@57723|Acidobacteria,2JIKK@204432|Acidobacteriia	204432|Acidobacteriia	T	Two component regulator propeller	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HKD1_k127_4788861_15	1382359.JIAL01000001_gene1850	1.058e-44	171.0	2ADDN@1|root,3133D@2|Bacteria,3Y4SX@57723|Acidobacteria,2JJFB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4788861_4	452637.Oter_4283	7.366e-302	946.0	COG0657@1|root,COG0657@2|Bacteria,46TU9@74201|Verrucomicrobia,3KA3K@414999|Opitutae	414999|Opitutae	I	Glycosyl hydrolase family 65, N-terminal domain	-	-	3.2.1.51	ko:K15923	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000	-	GH95	-	Glyco_hyd_65N_2
HKD1_k127_4788861_1	861299.J421_0364	0.0	1133.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	yicI	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_4788861_7	204669.Acid345_1682	6.934e-191	639.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IK@57723|Acidobacteria,2JKNM@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	TPR_2,TPR_8,UnbV_ASPIC,VCBS
HKD1_k127_4788861_16	1267534.KB906756_gene343	1.336e-37	147.0	COG0412@1|root,COG0412@2|Bacteria,3Y2PZ@57723|Acidobacteria,2JKJA@204432|Acidobacteriia	204432|Acidobacteriia	Q	Dienelactone hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4820168_6	7897.ENSLACP00000003562	0.0002844	47.0	COG1940@1|root,2QUGI@2759|Eukaryota,38S4V@33154|Opisthokonta,3BCQP@33208|Metazoa,3CSF1@33213|Bilateria,488ED@7711|Chordata,495ZK@7742|Vertebrata	33208|Metazoa	GK	N-acetylmannosamine kinase	GNE	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006040,GO:0006054,GO:0006082,GO:0006793,GO:0006796,GO:0007155,GO:0008150,GO:0008152,GO:0008761,GO:0009058,GO:0009384,GO:0009987,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0016853,GO:0016854,GO:0016857,GO:0016999,GO:0017000,GO:0017144,GO:0019200,GO:0019752,GO:0022610,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044262,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046349,GO:0046380,GO:0046394,GO:0046835,GO:0071704,GO:1901135,GO:1901137,GO:1901576	2.7.1.60,3.2.1.183	ko:K12409	ko00520,ko01100,map00520,map01100	-	R00414,R02705	RC00002,RC00005,RC00017,RC00288	ko00000,ko00001,ko01000	-	-	-	Epimerase_2,ROK
HKD1_k127_4820168_0	1232410.KI421416_gene2654	6.607e-178	572.0	COG1640@1|root,COG1640@2|Bacteria,1QTVJ@1224|Proteobacteria,42PZB@68525|delta/epsilon subdivisions,2WK77@28221|Deltaproteobacteria,43STY@69541|Desulfuromonadales	28221|Deltaproteobacteria	G	PFAM glycoside hydrolase, family 77	malQ	-	2.4.1.25	ko:K00705	ko00500,ko01100,map00500,map01100	-	R05196	RC00049	ko00000,ko00001,ko01000	-	GH77	-	Glyco_hydro_77
HKD1_k127_4820168_1	1122182.KB903833_gene5397	9.222e-89	305.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria,4DA29@85008|Micromonosporales	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_4820168_4	204669.Acid345_2978	4.769e-38	153.0	2CIGC@1|root,33XM2@2|Bacteria,3Y7X9@57723|Acidobacteria,2JN04@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4820168_3	1211777.BN77_2461	7.965e-47	182.0	COG2067@1|root,COG2067@2|Bacteria,1REWT@1224|Proteobacteria,2U8YQ@28211|Alphaproteobacteria,4B8DG@82115|Rhizobiaceae	28211|Alphaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4820168_2	1356852.N008_03090	2.581e-51	192.0	29SM0@1|root,30DSB@2|Bacteria,4NQ72@976|Bacteroidetes,47QJW@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD1_k127_4820168_5	314278.NB231_07442	1.952e-37	146.0	2E3RZ@1|root,32YPK@2|Bacteria,1NJYT@1224|Proteobacteria,1SHP1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4829538_21	383372.Rcas_1005	1.359e-51	186.0	COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,375H1@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_4829538_2	1283300.ATXB01000002_gene3088	7.196e-158	504.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,1RMFS@1236|Gammaproteobacteria,1XDJ1@135618|Methylococcales	1236|Gammaproteobacteria	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006531,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008987,GO:0009058,GO:0009066,GO:0009108,GO:0009117,GO:0009165,GO:0009435,GO:0009987,GO:0016053,GO:0017144,GO:0018130,GO:0019355,GO:0019359,GO:0019362,GO:0019363,GO:0019438,GO:0019637,GO:0019674,GO:0019752,GO:0019805,GO:0034627,GO:0034628,GO:0034641,GO:0034654,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046496,GO:0046874,GO:0048037,GO:0051186,GO:0051188,GO:0051536,GO:0051539,GO:0051540,GO:0055086,GO:0071704,GO:0072524,GO:0072525,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b0750,iAPECO1_1312.APECO1_1338,iB21_1397.B21_00692,iBWG_1329.BWG_0602,iECBD_1354.ECBD_2917,iECB_1328.ECB_00703,iECDH10B_1368.ECDH10B_0817,iECDH1ME8569_1439.ECDH1ME8569_0703,iECD_1391.ECD_00703,iECED1_1282.ECED1_0711,iECOK1_1307.ECOK1_0750,iECP_1309.ECP_0761,iECS88_1305.ECS88_0766,iECSP_1301.ECSP_0802,iECs_1301.ECs0778,iETEC_1333.ETEC_0754,iEcDH1_1363.EcDH1_2892,iEcolC_1368.EcolC_2912,iJN746.PP_1231,iJO1366.b0750,iJR904.b0750,iUMN146_1321.UM146_13905,iUTI89_1310.UTI89_C0747,iY75_1357.Y75_RS03905,iZ_1308.Z0919	NadA
HKD1_k127_4829538_1	1198114.AciX9_3738	5.945e-228	744.0	COG1629@1|root,COG4771@2|Bacteria,3Y42T@57723|Acidobacteria,2JIWF@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_4829538_3	1385513.N780_06200	4.121e-141	458.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,4H9RJ@91061|Bacilli,2Y8N8@289201|Pontibacillus	91061|Bacilli	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_4829538_18	452637.Oter_3517	5.094e-75	269.0	COG0793@1|root,COG0793@2|Bacteria	2|Bacteria	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_S41
HKD1_k127_4829538_23	1267533.KB906734_gene3891	7.404e-45	173.0	COG1714@1|root,COG1714@2|Bacteria	2|Bacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_4829538_33	449673.BACSTE_00557	0.0006667	44.0	2E3EN@1|root,32YDN@2|Bacteria,4NW0I@976|Bacteroidetes,2FZFW@200643|Bacteroidia	976|Bacteroidetes	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HKD1_k127_4829538_30	649638.Trad_1429	1.082e-11	68.0	2DQJV@1|root,337C3@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_4829538_19	1267533.KB906734_gene4160	2.02e-69	241.0	COG0299@1|root,COG0299@2|Bacteria,3Y49G@57723|Acidobacteria,2JJ2U@204432|Acidobacteriia	204432|Acidobacteriia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD1_k127_4829538_24	861299.J421_0700	6.447e-37	145.0	COG0454@1|root,COG1051@1|root,COG0456@2|Bacteria,COG1051@2|Bacteria	2|Bacteria	F	GDP-mannose mannosyl hydrolase activity	-	-	3.6.1.55,5.5.1.4	ko:K01858,ko:K03207,ko:K03574	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_4829538_5	240015.ACP_1372	2.595e-124	407.0	COG0150@1|root,COG0150@2|Bacteria,3Y2GN@57723|Acidobacteria,2JITJ@204432|Acidobacteriia	204432|Acidobacteriia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_4829538_22	1396.DJ87_2093	6.933e-49	190.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,4H9N3@91061|Bacilli,1ZBKV@1386|Bacillus	91061|Bacilli	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	HHH_3,Lactamase_B,SLH
HKD1_k127_4829538_8	880073.Calab_0792	3.725e-121	402.0	COG2252@1|root,COG2252@2|Bacteria,2NNZ2@2323|unclassified Bacteria	2|Bacteria	S	Permease family	-	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD1_k127_4829538_7	204669.Acid345_2367	1.968e-123	409.0	COG2008@1|root,COG2008@2|Bacteria,3Y472@57723|Acidobacteria,2JIUS@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_4829538_29	1156937.MFUM_180012	5.333e-12	74.0	COG1664@1|root,COG1664@2|Bacteria,46ZD9@74201|Verrucomicrobia,37HA8@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_4829538_13	335543.Sfum_1625	5.75e-87	309.0	COG5295@1|root,COG5295@2|Bacteria,1NI1M@1224|Proteobacteria,42ZTF@68525|delta/epsilon subdivisions,2WV01@28221|Deltaproteobacteria	28221|Deltaproteobacteria	UW	Chaperone of endosialidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S74,YadA_head
HKD1_k127_4829538_9	196367.JNFG01000050_gene1575	4.487e-106	353.0	COG0037@1|root,COG0037@2|Bacteria,1MW5Q@1224|Proteobacteria,2VHWH@28216|Betaproteobacteria,1K0VT@119060|Burkholderiaceae	28216|Betaproteobacteria	J	Catalyzes the ATP-dependent 2-thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32). The sulfur atoms are provided by the cysteine cysteine desulfurase (IscS) system	ttcA	-	-	ko:K14058	-	-	-	-	ko00000,ko03016	-	-	-	ATP_bind_3
HKD1_k127_4829538_17	1267535.KB906767_gene4165	2.071e-76	266.0	COG0142@1|root,COG0142@2|Bacteria,3Y2HS@57723|Acidobacteria,2JIPK@204432|Acidobacteriia	204432|Acidobacteriia	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_4829538_28	1453501.JELR01000002_gene516	2.089e-14	76.0	COG1722@1|root,COG1722@2|Bacteria,1N72V@1224|Proteobacteria,1SC7N@1236|Gammaproteobacteria,468UE@72275|Alteromonadaceae	1236|Gammaproteobacteria	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	GO:0003674,GO:0003824,GO:0004518,GO:0004527,GO:0004529,GO:0004536,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006308,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008855,GO:0009056,GO:0009057,GO:0009318,GO:0009987,GO:0016787,GO:0016788,GO:0016796,GO:0016895,GO:0019439,GO:0032991,GO:0034641,GO:0034655,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044260,GO:0044265,GO:0044270,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0140097,GO:1901360,GO:1901361,GO:1901575,GO:1902494	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD1_k127_4829538_10	204669.Acid345_0279	4.644e-106	360.0	COG1570@1|root,COG1570@2|Bacteria,3Y3DP@57723|Acidobacteria,2JIQN@204432|Acidobacteriia	204432|Acidobacteriia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD1_k127_4829538_0	886293.Sinac_1156	1.298e-311	996.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,2J2QS@203682|Planctomycetes	203682|Planctomycetes	KLT	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,Pkinase
HKD1_k127_4829538_25	644282.Deba_1971	2.609e-24	106.0	COG2119@1|root,COG2119@2|Bacteria,1NDE6@1224|Proteobacteria,42W66@68525|delta/epsilon subdivisions,2WS4K@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_4829538_11	485913.Krac_11550	4.741e-93	312.0	COG1814@1|root,COG1814@2|Bacteria,2G7AE@200795|Chloroflexi	200795|Chloroflexi	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_4829538_14	706587.Desti_1801	1.047e-81	279.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,43BI9@68525|delta/epsilon subdivisions,2X6WN@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_4829538_31	234267.Acid_4972	3.356e-07	60.0	COG2885@1|root,COG2885@2|Bacteria,3Y8DM@57723|Acidobacteria	57723|Acidobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4829538_27	1316936.K678_14317	4.872e-15	85.0	COG0457@1|root,COG0457@2|Bacteria,1MUZK@1224|Proteobacteria,2TS0U@28211|Alphaproteobacteria,2JPRT@204441|Rhodospirillales	204441|Rhodospirillales	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_9,TPR_1,TPR_10,TPR_11,TPR_16,TPR_19,TPR_2,TPR_4,TPR_7,TPR_8
HKD1_k127_4829538_6	886293.Sinac_3494	8.795e-124	405.0	COG0500@1|root,COG4742@1|root,COG2226@2|Bacteria,COG4742@2|Bacteria,2IXEP@203682|Planctomycetes	203682|Planctomycetes	Q	O-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Dimerisation2,Methyltransf_2
HKD1_k127_4829538_4	926569.ANT_00770	5.396e-134	483.0	COG2373@1|root,COG2373@2|Bacteria,2G8BN@200795|Chloroflexi	200795|Chloroflexi	S	A-macroglobulin receptor	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,A2M_recep,Thiol-ester_cl
HKD1_k127_4829538_15	1444309.JAQG01000021_gene1409	6.549e-80	282.0	COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,4HADV@91061|Bacilli,26SSK@186822|Paenibacillaceae	91061|Bacilli	J	Related to alanyl-tRNA synthetase HxxxH domain	alaS_2	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_4829538_12	1227739.Hsw_2021	7.991e-92	326.0	COG3975@1|root,COG3975@2|Bacteria,4NGTY@976|Bacteroidetes,47KE2@768503|Cytophagia	976|Bacteroidetes	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HKD1_k127_4829538_20	1120973.AQXL01000097_gene900	2.627e-66	237.0	COG0492@1|root,COG0492@2|Bacteria,1V4WN@1239|Firmicutes,4HHA8@91061|Bacilli,278DV@186823|Alicyclobacillaceae	91061|Bacilli	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_4829538_26	1444309.JAQG01000171_gene391	5.146e-21	98.0	COG1506@1|root,COG1506@2|Bacteria	2|Bacteria	E	serine-type peptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	AXE1,DLH,Peptidase_S9
HKD1_k127_4878917_3	1267533.KB906735_gene4441	8.361e-15	74.0	COG3119@1|root,COG3119@2|Bacteria	2|Bacteria	P	arylsulfatase activity	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase,Sulfatase_C
HKD1_k127_4878917_4	1169143.KB911035_gene2314	2.712e-05	53.0	COG2067@1|root,COG2067@2|Bacteria,1RJIQ@1224|Proteobacteria,2WFUS@28216|Betaproteobacteria	28216|Betaproteobacteria	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4878917_0	768671.ThimaDRAFT_2120	3.641e-70	241.0	29C7G@1|root,3163F@2|Bacteria,1QDGP@1224|Proteobacteria,1TKCK@1236|Gammaproteobacteria,1X1VP@135613|Chromatiales	135613|Chromatiales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4878917_2	497964.CfE428DRAFT_3484	9.749e-31	123.0	COG2261@1|root,COG2261@2|Bacteria	2|Bacteria	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD1_k127_4878917_1	478741.JAFS01000002_gene274	5.23e-61	214.0	COG0580@1|root,COG0580@2|Bacteria,46V4E@74201|Verrucomicrobia,37GHA@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	G	Major intrinsic protein	glpF	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_4918933_0	1173021.ALWA01000020_gene83	3.566e-293	923.0	COG3391@1|root,COG3511@1|root,COG3391@2|Bacteria,COG3511@2|Bacteria,1G3SH@1117|Cyanobacteria	2|Bacteria	M	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF1735,F5_F8_type_C,Lactonase,Phosphoesterase,SGL
HKD1_k127_4974890_0	330214.NIDE1392	2.64e-262	829.0	COG0046@1|root,COG0046@2|Bacteria,3J0TJ@40117|Nitrospirae	40117|Nitrospirae	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HKD1_k127_4974890_2	1279009.ADICEAN_01946	1.16e-20	98.0	COG0526@1|root,COG0526@2|Bacteria,4NQ9U@976|Bacteroidetes,47RGU@768503|Cytophagia	976|Bacteroidetes	CO	Thioredoxin	trxC	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Thioredoxin,Thioredoxin_8
HKD1_k127_4974890_1	1191523.MROS_1419	5.946e-51	188.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_4987475_17	321846.PS417_25035	6.438e-73	258.0	2CK9T@1|root,2Z7W9@2|Bacteria,1NEP3@1224|Proteobacteria,1S0HF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4987475_20	313606.M23134_05174	1.388e-60	218.0	COG2207@1|root,COG2207@2|Bacteria,4NHA5@976|Bacteroidetes	976|Bacteroidetes	K	AraC family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD1_k127_4987475_26	435908.IDSA_09340	3.829e-45	168.0	29E7I@1|root,3015I@2|Bacteria,1NCJP@1224|Proteobacteria,1SB4D@1236|Gammaproteobacteria,2QGVA@267893|Idiomarinaceae	1236|Gammaproteobacteria	S	Protein of unknown function (DUF1761)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1761
HKD1_k127_4987475_25	468059.AUHA01000002_gene919	2.298e-47	175.0	29KMP@1|root,2Z9ZF@2|Bacteria,4NKVK@976|Bacteroidetes	976|Bacteroidetes	S	Domain of unknown function (DUF4287)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4287
HKD1_k127_4987475_9	768670.Calni_0847	1.847e-109	396.0	COG2319@1|root,COG4249@1|root,COG2319@2|Bacteria,COG4249@2|Bacteria,2GG9I@200930|Deferribacteres	200930|Deferribacteres	G	peptidase C14 caspase catalytic subunit p20	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HKD1_k127_4987475_3	234267.Acid_0709	2.524e-159	512.0	COG4656@1|root,COG4656@2|Bacteria	2|Bacteria	C	electron transfer activity	rnfC	-	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4_10,Fer4_17,RnfC_N,SLBB
HKD1_k127_4987475_16	234267.Acid_0708	2.492e-75	257.0	COG4577@1|root,COG4577@2|Bacteria	2|Bacteria	CQ	ethanolamine catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_4987475_23	1449044.JMLE01000014_gene2406	1.312e-54	200.0	28PHV@1|root,2ZC86@2|Bacteria,2IEHK@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4987475_12	1232410.KI421413_gene633	5.071e-90	299.0	2AUXR@1|root,2ZBPW@2|Bacteria,1RAID@1224|Proteobacteria,42QWQ@68525|delta/epsilon subdivisions,2WMRI@28221|Deltaproteobacteria,43T93@69541|Desulfuromonadales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4987475_34	649639.Bcell_0815	1.019e-27	121.0	COG1309@1|root,COG1309@2|Bacteria,1TSUJ@1239|Firmicutes,4HJER@91061|Bacilli,1ZRHP@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator C-terminal region	XK27_03525	-	-	-	-	-	-	-	-	-	-	-	TetR_C_8,TetR_N
HKD1_k127_4987475_46	1340493.JNIF01000003_gene4136	0.0003671	48.0	2EMD6@1|root,33F24@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4987475_38	485913.Krac_9819	1.834e-22	99.0	2DQBG@1|root,335T7@2|Bacteria,2G96K@200795|Chloroflexi	200795|Chloroflexi	C	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	-	-	-	-	-	-	-	-	-	-	GRDB
HKD1_k127_4987475_30	485913.Krac_9819	1.98e-39	153.0	2DQBG@1|root,335T7@2|Bacteria,2G96K@200795|Chloroflexi	200795|Chloroflexi	C	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	-	-	-	-	-	-	-	-	-	-	-	-	GRDB
HKD1_k127_4987475_31	1120973.AQXL01000135_gene1319	2.542e-37	142.0	COG1225@1|root,COG1225@2|Bacteria,1V6MU@1239|Firmicutes,4HK8J@91061|Bacilli,27A0F@186823|Alicyclobacillaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_4987475_41	330214.NIDE4033	5.533e-11	64.0	COG1225@1|root,COG1225@2|Bacteria,3J12D@40117|Nitrospirae	40117|Nitrospirae	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_4987475_35	479434.Sthe_1521	4.645e-27	115.0	COG0735@1|root,COG0735@2|Bacteria,2G92T@200795|Chloroflexi,27YA1@189775|Thermomicrobia	189775|Thermomicrobia	K	Ferric uptake regulator family	-	-	-	ko:K09825	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_4987475_15	1341151.ASZU01000006_gene2792	4.775e-79	269.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,4HA2M@91061|Bacilli,27B7C@186824|Thermoactinomycetaceae	91061|Bacilli	O	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_4987475_29	272558.10175285	1.936e-41	161.0	COG0526@1|root,COG0526@2|Bacteria,1V1R4@1239|Firmicutes,4HFWU@91061|Bacilli,1ZBFR@1386|Bacillus	91061|Bacilli	CO	thiol-disulfide	ykuV	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_4987475_2	1267534.KB906758_gene2303	7.698e-205	684.0	COG1629@1|root,COG4771@2|Bacteria,3Y77Y@57723|Acidobacteria,2JKVG@204432|Acidobacteriia	204432|Acidobacteriia	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_4987475_27	886293.Sinac_7078	1.469e-43	174.0	COG0644@1|root,COG0644@2|Bacteria,2IZDK@203682|Planctomycetes	203682|Planctomycetes	C	FAD binding domain	-	-	1.3.99.38	ko:K21401	-	-	-	-	ko00000,ko01000	-	-	-	FAD_binding_3
HKD1_k127_4987475_28	404380.Gbem_1026	9.744e-43	166.0	COG0500@1|root,COG2226@2|Bacteria,1QYSR@1224|Proteobacteria,42Z2G@68525|delta/epsilon subdivisions,2WUBA@28221|Deltaproteobacteria	28221|Deltaproteobacteria	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4987475_40	1120970.AUBZ01000022_gene1254	2.602e-11	65.0	COG4637@1|root,COG4637@2|Bacteria,1ND40@1224|Proteobacteria,1RPX7@1236|Gammaproteobacteria,4660N@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15,AAA_21
HKD1_k127_4987475_4	234267.Acid_1914	2.73e-141	460.0	COG0304@1|root,COG0304@2|Bacteria,3Y43C@57723|Acidobacteria	57723|Acidobacteria	IQ	Beta-ketoacyl synthase, C-terminal domain	-	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_4987475_21	1239962.C943_00155	1.674e-60	222.0	COG3055@1|root,COG3055@2|Bacteria	2|Bacteria	G	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	DUF3386,Kelch_1,Kelch_5,fn3
HKD1_k127_4987475_1	1229487.AMYW01000018_gene4138	1.569e-213	688.0	COG0160@1|root,COG2334@1|root,COG0160@2|Bacteria,COG2334@2|Bacteria,4NFMP@976|Bacteroidetes,1HZ97@117743|Flavobacteriia,2NVD7@237|Flavobacterium	976|Bacteroidetes	E	Phosphotransferase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	APH,Aminotran_3,Peptidase_M23
HKD1_k127_4987475_10	1242864.D187_000932	2.425e-100	346.0	COG0596@1|root,COG0596@2|Bacteria,1R6KU@1224|Proteobacteria	1224|Proteobacteria	G	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD1_k127_4987475_24	1144343.PMI41_01170	4.995e-50	196.0	COG0793@1|root,COG0793@2|Bacteria,1N5BU@1224|Proteobacteria,2UM02@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4987475_5	1047013.AQSP01000119_gene1312	5.628e-133	432.0	COG3938@1|root,COG3938@2|Bacteria,2NQES@2323|unclassified Bacteria	2|Bacteria	E	Proline racemase	-	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016854,GO:0016855,GO:0018112,GO:0019752,GO:0036361,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0050346,GO:0071704,GO:1901564	5.1.1.4	ko:K01777	ko00330,ko01100,map00330,map01100	-	R01255	RC00479	ko00000,ko00001,ko01000	-	-	-	Pro_racemase
HKD1_k127_4987475_7	1120746.CCNL01000006_gene373	8.419e-121	398.0	COG4260@1|root,COG4260@2|Bacteria	2|Bacteria	N	virion core protein, lumpy skin disease virus	ydjI	-	-	-	-	-	-	-	-	-	-	-	Band_7_1,DUF4339,SHOCT
HKD1_k127_4987475_37	56780.SYN_03077	1.407e-23	106.0	COG5652@1|root,COG5652@2|Bacteria,1PUUC@1224|Proteobacteria,43F3B@68525|delta/epsilon subdivisions,2X381@28221|Deltaproteobacteria,2MSC7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	VanZ like family	-	-	-	-	-	-	-	-	-	-	-	-	VanZ
HKD1_k127_4987475_6	497964.CfE428DRAFT_5023	1.95e-124	410.0	COG0577@1|root,COG0577@2|Bacteria,46U7K@74201|Verrucomicrobia	74201|Verrucomicrobia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_4987475_11	1304874.JAFY01000002_gene147	8.043e-92	309.0	COG1136@1|root,COG1136@2|Bacteria,3TAPT@508458|Synergistetes	508458|Synergistetes	P	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4987475_13	671143.DAMO_3155	2.228e-89	316.0	COG0845@1|root,COG0845@2|Bacteria,2NPBH@2323|unclassified Bacteria	2|Bacteria	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	macA_1	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	HlyD_D23
HKD1_k127_4987475_45	1002339.HMPREF9373_0999	1.961e-05	53.0	COG3678@1|root,COG3678@2|Bacteria,1RBDH@1224|Proteobacteria,1S2DT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	NPTU	P pilus assembly Cpx signaling pathway, periplasmic inhibitor zinc-resistance associated protein	spy	-	-	-	-	-	-	-	-	-	-	-	LTXXQ
HKD1_k127_4987475_33	497964.CfE428DRAFT_1388	2.657e-29	124.0	COG1595@1|root,COG1595@2|Bacteria,46STJ@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_4987475_8	335543.Sfum_3053	3.168e-115	383.0	COG2234@1|root,COG2234@2|Bacteria,1MXZS@1224|Proteobacteria,42S82@68525|delta/epsilon subdivisions,2WNUR@28221|Deltaproteobacteria,2MR3S@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	PFAM peptidase M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_4987475_14	1340493.JNIF01000004_gene350	5.046e-86	293.0	COG0224@1|root,COG0224@2|Bacteria,3Y3MN@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD1_k127_4987475_0	1340493.JNIF01000004_gene349	2.257e-231	725.0	COG0056@1|root,COG0056@2|Bacteria,3Y2R6@57723|Acidobacteria	57723|Acidobacteria	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD1_k127_4987475_32	518766.Rmar_0314	1.412e-29	124.0	COG0712@1|root,COG0712@2|Bacteria,4NSNF@976|Bacteroidetes,1FJFS@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD1_k127_4987475_42	56780.SYN_00548	2.246e-10	68.0	COG0711@1|root,COG0711@2|Bacteria,1N97K@1224|Proteobacteria,42VYP@68525|delta/epsilon subdivisions,2WR6T@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	GO:0003674,GO:0003824,GO:0005215,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0006139,GO:0006163,GO:0006164,GO:0006725,GO:0006753,GO:0006754,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0008324,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015318,GO:0015399,GO:0015405,GO:0015672,GO:0015985,GO:0015986,GO:0016020,GO:0016462,GO:0016469,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0017144,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0032991,GO:0033177,GO:0034220,GO:0034641,GO:0034654,GO:0042623,GO:0042625,GO:0042626,GO:0043492,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0044769,GO:0045259,GO:0045260,GO:0045263,GO:0045264,GO:0046034,GO:0046390,GO:0046483,GO:0046933,GO:0051179,GO:0051234,GO:0055085,GO:0055086,GO:0071704,GO:0071944,GO:0072521,GO:0072522,GO:0090407,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0098796,GO:0098797,GO:0099131,GO:0099132,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1902600	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_4987475_47	338966.Ppro_0601	0.0009159	48.0	COG0711@1|root,COG0711@2|Bacteria,1NA9K@1224|Proteobacteria,42VN2@68525|delta/epsilon subdivisions,2WR8C@28221|Deltaproteobacteria,43VA3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpX	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD1_k127_4987475_39	234267.Acid_1093	1.271e-14	74.0	COG0230@1|root,COG0230@2|Bacteria,3Y5W7@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD1_k127_4987475_44	227377.CBU_1918	3.807e-09	64.0	COG0594@1|root,COG0594@2|Bacteria,1MZQE@1224|Proteobacteria,1S90M@1236|Gammaproteobacteria	1236|Gammaproteobacteria	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	GO:0000966,GO:0001682,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004526,GO:0004540,GO:0004549,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005655,GO:0005730,GO:0006139,GO:0006396,GO:0006399,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0030677,GO:0030681,GO:0031974,GO:0031981,GO:0032991,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0044237,GO:0044238,GO:0044422,GO:0044424,GO:0044428,GO:0044446,GO:0044452,GO:0044464,GO:0046483,GO:0070013,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0099116,GO:0140098,GO:0140101,GO:1901360,GO:1902494,GO:1902555,GO:1905348,GO:1990904	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_4987475_36	643562.Daes_2574	2.284e-25	106.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,42VNC@68525|delta/epsilon subdivisions,2WRIM@28221|Deltaproteobacteria,2MD5H@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD1_k127_4987475_22	1267535.KB906767_gene3477	1.095e-55	218.0	COG0706@1|root,COG0706@2|Bacteria,3Y3TD@57723|Acidobacteria,2JI2B@204432|Acidobacteriia	204432|Acidobacteriia	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD1_k127_4987475_19	700598.Niako_2915	2.832e-62	224.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	MA20_39355	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_4987475_18	1267533.KB906733_gene2908	2.819e-65	229.0	COG0262@1|root,COG0262@2|Bacteria	2|Bacteria	H	dihydrofolate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_5027634_3	886293.Sinac_6462	2.173e-160	511.0	COG0451@1|root,COG0451@2|Bacteria,2IX7V@203682|Planctomycetes	203682|Planctomycetes	M	PFAM NAD-dependent epimerase dehydratase	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_5027634_13	1499967.BAYZ01000186_gene3970	6.939e-81	285.0	COG0438@1|root,COG0438@2|Bacteria,2NR2T@2323|unclassified Bacteria	2|Bacteria	M	Glycosyl transferase 4-like	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_5027634_5	479434.Sthe_1140	6.17e-136	442.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_5027634_21	1123508.JH636440_gene1986	6.346e-57	203.0	COG1898@1|root,COG1898@2|Bacteria,2J35V@203682|Planctomycetes	203682|Planctomycetes	M	dTDP-4-dehydrorhamnose 3,5-epimerase	-	-	-	-	-	-	-	-	-	-	-	-	dTDP_sugar_isom
HKD1_k127_5027634_7	330214.NIDE3016	9.465e-119	386.0	COG1209@1|root,COG1209@2|Bacteria,3J0KX@40117|Nitrospirae	40117|Nitrospirae	M	Nucleotidyl transferase	-	-	2.7.7.24	ko:K00973	ko00521,ko00523,ko00525,ko01130,map00521,map00523,map00525,map01130	M00793	R02328	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_5027634_26	648757.Rvan_0400	1.125e-34	145.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_5027634_1	1499967.BAYZ01000026_gene1631	3.241e-193	621.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_5027634_25	443144.GM21_2071	1.322e-37	151.0	COG0730@1|root,COG0730@2|Bacteria,1RD5A@1224|Proteobacteria	1224|Proteobacteria	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_5027634_37	1089553.Tph_c14180	0.0002139	53.0	COG1807@1|root,COG1807@2|Bacteria,1V1HJ@1239|Firmicutes,249BG@186801|Clostridia,42HAV@68295|Thermoanaerobacterales	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_5027634_12	402777.KB235903_gene663	1.791e-85	297.0	COG2755@1|root,COG2755@2|Bacteria,1G060@1117|Cyanobacteria,1H9JP@1150|Oscillatoriales	1117|Cyanobacteria	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL
HKD1_k127_5027634_11	344747.PM8797T_27627	9.768e-93	310.0	COG0224@1|root,COG0224@2|Bacteria,2J3E7@203682|Planctomycetes	203682|Planctomycetes	C	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
HKD1_k127_5027634_17	1003200.AXXA_09528	4.776e-65	229.0	COG4106@1|root,COG4106@2|Bacteria,1QVY9@1224|Proteobacteria,2VYG7@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_5027634_14	402881.Plav_3311	8.57e-81	274.0	COG0110@1|root,COG0110@2|Bacteria,1RAKB@1224|Proteobacteria,2U3JX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_5027634_29	56110.Oscil6304_0526	4.681e-30	137.0	COG0438@1|root,COG1196@1|root,COG3914@1|root,COG0438@2|Bacteria,COG1196@2|Bacteria,COG3914@2|Bacteria	2|Bacteria	O	protein N-acetylglucosaminyltransferase activity	hb6	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Glyco_transf_41,Glycos_transf_1,Glycos_transf_2,Methyltransf_21
HKD1_k127_5027634_16	1205753.A989_01415	9.565e-76	275.0	COG1216@1|root,COG1216@2|Bacteria,1NC70@1224|Proteobacteria,1T49B@1236|Gammaproteobacteria,1XDCE@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5027634_8	93220.LV28_04960	2.07e-111	368.0	COG1621@1|root,COG1621@2|Bacteria,1N5AZ@1224|Proteobacteria,2VQMQ@28216|Betaproteobacteria,1K21E@119060|Burkholderiaceae	28216|Betaproteobacteria	G	beta-fructofuranosidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5027634_24	1462526.BN990_01139	1.989e-40	154.0	COG2076@1|root,COG2076@2|Bacteria,1VF8J@1239|Firmicutes,4IRV7@91061|Bacilli	91061|Bacilli	P	Small Multidrug Resistance protein	arnF	-	-	-	-	-	-	-	-	-	-	-	EamA,Multi_Drug_Res
HKD1_k127_5027634_2	489825.LYNGBM3L_45070	2.381e-181	574.0	COG0399@1|root,COG0399@2|Bacteria,1G47X@1117|Cyanobacteria,1H9EC@1150|Oscillatoriales	1117|Cyanobacteria	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_5027634_27	1122621.ATZA01000011_gene415	2.191e-34	140.0	COG1651@1|root,COG1651@2|Bacteria,4NQ9P@976|Bacteroidetes,1ISGX@117747|Sphingobacteriia	976|Bacteroidetes	O	PFAM DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD1_k127_5027634_9	1230343.CANP01000029_gene2126	4.687e-103	345.0	2AUD4@1|root,31K11@2|Bacteria,1RI0U@1224|Proteobacteria	1224|Proteobacteria	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD1_k127_5027634_6	1230343.CANP01000029_gene2126	4.984e-120	394.0	2AUD4@1|root,31K11@2|Bacteria,1RI0U@1224|Proteobacteria	1224|Proteobacteria	S	Parallel beta-helix repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix
HKD1_k127_5027634_31	215803.DB30_2010	5.756e-24	119.0	COG1572@1|root,COG1572@2|Bacteria,1QX45@1224|Proteobacteria,42YA1@68525|delta/epsilon subdivisions,2WTP9@28221|Deltaproteobacteria,2YYU3@29|Myxococcales	28221|Deltaproteobacteria	S	HYR domain	-	-	-	-	-	-	-	-	-	-	-	-	HYR,PQQ_2,VCBS
HKD1_k127_5027634_15	1217718.ALOU01000069_gene4841	2.475e-78	277.0	COG0728@1|root,COG0728@2|Bacteria	2|Bacteria	M	peptidoglycan biosynthetic process	pslK	-	-	ko:K03980,ko:K21004	ko02025,map02025	-	-	-	ko00000,ko00001,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD1_k127_5027634_32	316274.Haur_3709	5.327e-17	94.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_5027634_20	1121015.N789_03400	9.44e-60	215.0	COG0110@1|root,COG0110@2|Bacteria,1NMFJ@1224|Proteobacteria	1224|Proteobacteria	S	maltose O-acetyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_5027634_19	1313301.AUGC01000001_gene1578	9.519e-64	232.0	COG0438@1|root,COG0438@2|Bacteria,4NJ6W@976|Bacteroidetes	976|Bacteroidetes	M	Pfam Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD1_k127_5027634_23	237368.SCABRO_01338	2.967e-41	166.0	COG0500@1|root,COG2835@1|root,COG0500@2|Bacteria,COG2835@2|Bacteria,2IYVX@203682|Planctomycetes	203682|Planctomycetes	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_5027634_18	313606.M23134_04578	1.742e-64	237.0	COG0438@1|root,COG0438@2|Bacteria,4NG0D@976|Bacteroidetes,47KPB@768503|Cytophagia	976|Bacteroidetes	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_5027634_30	272844.PAB0796	1.211e-29	130.0	COG0463@1|root,arCOG01385@2157|Archaea,2Y7SN@28890|Euryarchaeota,2456V@183968|Thermococci	183968|Thermococci	M	Glycosyl transferase family group 2	-	-	2.4.1.335	ko:K21305	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	-	Glycos_transf_2
HKD1_k127_5027634_4	479434.Sthe_3442	1.206e-149	479.0	COG0451@1|root,COG0451@2|Bacteria,2G64F@200795|Chloroflexi,27XSM@189775|Thermomicrobia	2|Bacteria	GM	3-beta hydroxysteroid dehydrogenase/isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_5027634_0	945713.IALB_2724	2.482e-264	828.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD1_k127_5027634_33	1205680.CAKO01000038_gene1839	4.776e-14	72.0	2EGPU@1|root,33AFZ@2|Bacteria,1NH69@1224|Proteobacteria,2UJXH@28211|Alphaproteobacteria,2JYAX@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5027634_36	388467.A19Y_3288	1.535e-05	53.0	2DP8V@1|root,33122@2|Bacteria,1G83J@1117|Cyanobacteria,1HB8R@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5027634_22	1403819.BATR01000045_gene1317	1.2e-50	190.0	COG1216@1|root,COG1216@2|Bacteria,46SZ2@74201|Verrucomicrobia,2IVQI@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5027634_10	1519464.HY22_10225	3.886e-96	319.0	COG0673@1|root,COG0673@2|Bacteria,1FEZX@1090|Chlorobi	1090|Chlorobi	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_5036136_6	1123392.AQWL01000005_gene3086	7.944e-64	223.0	COG5483@1|root,COG5483@2|Bacteria,1RDGV@1224|Proteobacteria,2VV76@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD1_k127_5036136_1	1267535.KB906767_gene3266	1.159e-220	694.0	COG0364@1|root,COG0364@2|Bacteria,3Y2JZ@57723|Acidobacteria,2JHKE@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	-	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD1_k127_5036136_2	1174528.JH992893_gene5976	7.416e-161	512.0	COG1023@1|root,COG1023@2|Bacteria,1G07T@1117|Cyanobacteria,1JMU3@1189|Stigonemataceae	1117|Cyanobacteria	G	6-phosphogluconate dehydrogenase, C-terminal domain	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD1_k127_5036136_0	1174528.JH992893_gene5975	4.618e-242	760.0	COG0166@1|root,COG0176@1|root,COG0166@2|Bacteria,COG0176@2|Bacteria,1G15G@1117|Cyanobacteria,1JHXK@1189|Stigonemataceae	1117|Cyanobacteria	G	Transaldolase/Fructose-6-phosphate aldolase	-	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_5036136_3	1267535.KB906767_gene4340	9.061e-126	411.0	COG0182@1|root,COG0182@2|Bacteria,3Y2TR@57723|Acidobacteria,2JHZX@204432|Acidobacteriia	204432|Acidobacteriia	J	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)	mtnA	-	5.3.1.23	ko:K08963	ko00270,ko01100,map00270,map01100	M00034	R04420	RC01151	ko00000,ko00001,ko00002,ko01000	-	-	-	IF-2B
HKD1_k127_5036136_8	1379270.AUXF01000001_gene2468	1.397e-24	110.0	COG2318@1|root,COG2318@2|Bacteria,1ZV11@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_5036136_7	1209989.TepiRe1_1096	2.306e-50	195.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,42FIR@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_5036136_5	653733.Selin_1608	3.224e-64	234.0	COG0609@1|root,COG0609@2|Bacteria	2|Bacteria	P	iron ion homeostasis	btuC	-	3.6.3.34	ko:K02013,ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_5036136_10	1122222.AXWR01000053_gene57	1.89e-11	71.0	COG2102@1|root,COG2102@2|Bacteria	2|Bacteria	S	diphthine-ammonia ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
HKD1_k127_5036136_4	228410.NE1564	1.735e-68	237.0	COG2102@1|root,COG2102@2|Bacteria,1MUU2@1224|Proteobacteria,2WFQ9@28216|Betaproteobacteria,37408@32003|Nitrosomonadales	28216|Betaproteobacteria	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
HKD1_k127_5036136_9	863239.AFIZ01000032_gene1940	2.467e-17	85.0	COG1120@1|root,COG1120@2|Bacteria,2GN5T@201174|Actinobacteria,22R7P@1653|Corynebacteriaceae	201174|Actinobacteria	HP	transport systems ATPase components	znuC2	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD1_k127_5042469_36	234267.Acid_5217	1.859e-47	177.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_5042469_27	234267.Acid_1209	2.488e-62	220.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_5042469_47	395961.Cyan7425_0783	3.778e-30	132.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G7ID@1117|Cyanobacteria,3KHZI@43988|Cyanothece	1117|Cyanobacteria	O	Peptidase S1 and S6 chymotrypsin Hap	-	-	-	-	-	-	-	-	-	-	-	-	GUN4,TPR_1,TPR_11,TPR_8,Trypsin_2
HKD1_k127_5042469_63	43989.cce_3457	9.926e-06	53.0	29WFE@1|root,30I19@2|Bacteria,1GQ76@1117|Cyanobacteria,3KIWC@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_52	1283300.ATXB01000001_gene904	5.653e-20	100.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,1RNVA@1236|Gammaproteobacteria,1XFUV@135618|Methylococcales	135618|Methylococcales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5,TPR_1,TPR_2,TPR_8
HKD1_k127_5042469_7	929562.Emtol_0970	5.876e-183	586.0	COG0624@1|root,COG0624@2|Bacteria,4NEA7@976|Bacteroidetes,47JSS@768503|Cytophagia	976|Bacteroidetes	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5042469_34	1122915.AUGY01000099_gene3654	7.64e-48	176.0	COG2318@1|root,COG2318@2|Bacteria,1V6MV@1239|Firmicutes,4HH68@91061|Bacilli,26YC6@186822|Paenibacillaceae	91061|Bacilli	S	Squalene--hopene cyclase	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_5042469_62	420662.Mpe_A1637	5.387e-06	54.0	COG5569@1|root,COG5569@2|Bacteria,1N8CJ@1224|Proteobacteria,2VVSU@28216|Betaproteobacteria,1KNZA@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	Copper binding periplasmic protein CusF	cusF	-	-	-	-	-	-	-	-	-	-	-	CusF_Ec
HKD1_k127_5042469_42	401053.AciPR4_2475	2.985e-38	154.0	2B1QU@1|root,31U6H@2|Bacteria,3Y5EE@57723|Acidobacteria,2JJUF@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF3224)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3224
HKD1_k127_5042469_3	234267.Acid_5430	4.609e-219	702.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y6TN@57723|Acidobacteria	57723|Acidobacteria	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_5042469_44	1121931.AUHG01000010_gene507	1.143e-33	136.0	2DEWP@1|root,2ZPJE@2|Bacteria	2|Bacteria	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD1_k127_5042469_60	1500890.JQNL01000001_gene2468	1.287e-07	65.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,1RQQV@1236|Gammaproteobacteria,1X306@135614|Xanthomonadales	135614|Xanthomonadales	MU	TIGRFAM type I secretion outer membrane protein, TolC family	raxC	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD1_k127_5042469_9	716928.AJQT01000043_gene3171	2.347e-119	399.0	COG1653@1|root,COG1653@2|Bacteria,1MUNZ@1224|Proteobacteria,2U2Z9@28211|Alphaproteobacteria,4BCTU@82115|Rhizobiaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K02027	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	SBP_bac_1
HKD1_k127_5042469_20	1499967.BAYZ01000009_gene5384	7.037e-85	290.0	COG1175@1|root,COG1175@2|Bacteria	2|Bacteria	P	transmembrane transport	-	-	-	ko:K02025,ko:K15771	ko02010,map02010	M00207,M00491	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1,3.A.1.1.16,3.A.1.1.2	-	-	BPD_transp_1
HKD1_k127_5042469_13	1499967.BAYZ01000009_gene5385	1.273e-96	323.0	COG0395@1|root,COG0395@2|Bacteria	2|Bacteria	P	glycerophosphodiester transmembrane transport	-	-	-	ko:K02026	-	M00207	-	-	ko00000,ko00002,ko02000	3.A.1.1	-	-	BPD_transp_1
HKD1_k127_5042469_10	670487.Ocepr_1240	2.979e-115	381.0	COG3842@1|root,COG3842@2|Bacteria,1WIB1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ABC transporter	-	-	-	ko:K10112	ko02010,map02010	M00194,M00196,M00197,M00200,M00201,M00206,M00207,M00491,M00602,M00605,M00606	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1	-	-	ABC_tran,TOBE,TOBE_2
HKD1_k127_5042469_26	1295642.H839_06979	1.536e-64	231.0	COG1082@1|root,COG1082@2|Bacteria,1TS20@1239|Firmicutes,4HD4V@91061|Bacilli,1WG70@129337|Geobacillus	91061|Bacilli	G	Xylose isomerase-like TIM barrel	iolI	-	5.3.99.11	ko:K06606	ko00562,ko01120,map00562,map01120	-	R09952	RC01513	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_5042469_19	1295642.H839_06949	1.233e-86	297.0	COG0673@1|root,COG0673@2|Bacteria,1TW1D@1239|Firmicutes,4I4QS@91061|Bacilli,1WFPB@129337|Geobacillus	91061|Bacilli	S	Homoserine dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5042469_46	1340493.JNIF01000004_gene771	3.289e-30	134.0	COG0633@1|root,COG0633@2|Bacteria	2|Bacteria	C	Ferredoxin	-	GO:0005575,GO:0005622,GO:0005623,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044424,GO:0044464,GO:0046858	1.18.1.3	ko:K00529,ko:K04755,ko:K08952,ko:K08953,ko:K08954,ko:K15765	ko00071,ko00360,ko00623,ko00920,ko01100,ko01120,ko01220,map00071,map00360,map00623,map00920,map01100,map01120,map01220	M00538,M00545	R02000,R02550,R03562,R05666,R06782,R06783,R09513	RC00098,RC00269,RC00490,RC02556	br01602,ko00000,ko00001,ko00002,ko00194,ko01000	-	-	-	FAD_binding_6,Fer2
HKD1_k127_5042469_25	945713.IALB_1247	1.752e-68	243.0	COG0697@1|root,COG0697@2|Bacteria	2|Bacteria	EG	spore germination	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_5042469_35	1184267.A11Q_79	1.358e-47	178.0	2AY4N@1|root,31Q6J@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_0	1267535.KB906767_gene4853	0.0	1088.0	COG1274@1|root,COG1274@2|Bacteria,3Y2IH@57723|Acidobacteria,2JIZH@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD1_k127_5042469_51	237727.NAP1_15618	2.141e-23	112.0	COG2885@1|root,COG2885@2|Bacteria,1R5IS@1224|Proteobacteria,2U2V8@28211|Alphaproteobacteria,2K1H8@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_5042469_59	1382359.JIAL01000001_gene410	2.36e-09	69.0	COG0457@1|root,COG0457@2|Bacteria,3Y4E6@57723|Acidobacteria,2JKG2@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_2
HKD1_k127_5042469_54	706587.Desti_3938	1.046e-17	89.0	COG1847@1|root,COG1847@2|Bacteria,1RB1P@1224|Proteobacteria,42QPK@68525|delta/epsilon subdivisions,2WN58@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	PFAM Single-stranded nucleic acid binding R3H	-	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HKD1_k127_5042469_11	639030.JHVA01000001_gene2324	1.077e-112	379.0	COG0486@1|root,COG0486@2|Bacteria,3Y3QJ@57723|Acidobacteria,2JHNN@204432|Acidobacteriia	204432|Acidobacteriia	S	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD1_k127_5042469_5	240015.ACP_2349	8.949e-205	654.0	COG0445@1|root,COG0445@2|Bacteria,3Y3E4@57723|Acidobacteria,2JHP3@204432|Acidobacteriia	204432|Acidobacteriia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD1_k127_5042469_17	760568.Desku_3563	4.457e-88	299.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,2603P@186807|Peptococcaceae	186801|Clostridia	D	PFAM CobQ CobB MinD ParA nucleotide binding domain	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_5042469_24	1121920.AUAU01000007_gene449	7.629e-69	244.0	COG1475@1|root,COG1475@2|Bacteria,3Y40Y@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the ParB family	-	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_5042469_8	332101.JIBU02000034_gene1859	1.028e-127	422.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,36DSQ@31979|Clostridiaceae	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_5042469_15	204669.Acid345_0002	7.853e-94	321.0	COG0592@1|root,COG0592@2|Bacteria,3Y2WE@57723|Acidobacteria,2JI4X@204432|Acidobacteriia	204432|Acidobacteriia	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	-	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD1_k127_5042469_30	574087.Acear_0004	1.487e-51	197.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,3WA8H@53433|Halanaerobiales	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD1_k127_5042469_2	1232410.KI421422_gene2032	3.704e-292	918.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,42M7M@68525|delta/epsilon subdivisions,2WJ9X@28221|Deltaproteobacteria,43SYW@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_5042469_14	1183438.GKIL_3983	5.317e-94	321.0	COG0665@1|root,COG0665@2|Bacteria	2|Bacteria	E	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Trp_halogenase
HKD1_k127_5042469_48	1122613.ATUP01000001_gene1876	2.563e-26	116.0	2EF1A@1|root,338UD@2|Bacteria,1PB4D@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_61	391009.Tmel_1621	6.161e-07	56.0	COG1366@1|root,COG1366@2|Bacteria,2GDAN@200918|Thermotogae	200918|Thermotogae	T	PFAM Sulfate transporter antisigma-factor antagonist STAS	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD1_k127_5042469_18	357808.RoseRS_1529	8.562e-87	302.0	COG0515@1|root,COG0515@2|Bacteria,2GACY@200795|Chloroflexi,375GK@32061|Chloroflexia	32061|Chloroflexia	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_5042469_41	497964.CfE428DRAFT_2814	7.319e-40	153.0	COG1943@1|root,COG1943@2|Bacteria,46VP6@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_5042469_37	485913.Krac_2611	4.896e-47	175.0	2BHPS@1|root,32BT1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_45	316058.RPB_1950	6.453e-33	134.0	2F9XY@1|root,34278@2|Bacteria,1NZDW@1224|Proteobacteria,2UTVM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_22	326427.Cagg_0461	1.208e-75	261.0	COG1403@1|root,COG1403@2|Bacteria,2G8HM@200795|Chloroflexi	200795|Chloroflexi	L	SAD/SRA domain	-	-	-	-	-	-	-	-	-	-	-	-	HNH,SAD_SRA
HKD1_k127_5042469_1	204669.Acid345_3936	2.476e-308	960.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y6VR@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_5042469_23	1379270.AUXF01000001_gene2097	6.896e-72	254.0	2B33H@1|root,31VR5@2|Bacteria,1ZUG1@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_21	44454.NF84_14150	1.073e-79	276.0	COG1793@1|root,COG1793@2|Bacteria,2IKE5@201174|Actinobacteria,234HP@1762|Mycobacteriaceae	201174|Actinobacteria	L	ATP dependent DNA ligase C terminal region	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_5042469_58	1214101.BN159_2554	1.076e-10	71.0	COG2133@1|root,COG3291@1|root,COG3828@1|root,COG2133@2|Bacteria,COG3291@2|Bacteria,COG3828@2|Bacteria,2GJFY@201174|Actinobacteria	201174|Actinobacteria	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	CBM_6,DUF1349,GSDH,PKD,RicinB_lectin_2,ThuA
HKD1_k127_5042469_4	1303518.CCALI_00492	5.227e-210	674.0	COG0855@1|root,COG0855@2|Bacteria	2|Bacteria	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	GO:0000287,GO:0001666,GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0007154,GO:0008150,GO:0008152,GO:0008976,GO:0009267,GO:0009405,GO:0009605,GO:0009628,GO:0009987,GO:0009991,GO:0015968,GO:0016020,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019538,GO:0031667,GO:0031668,GO:0031669,GO:0033554,GO:0036211,GO:0036293,GO:0040007,GO:0042594,GO:0043167,GO:0043169,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044419,GO:0044464,GO:0046777,GO:0046872,GO:0050896,GO:0051704,GO:0051716,GO:0070482,GO:0071496,GO:0071704,GO:0071944,GO:1901564	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD1_k127_5042469_31	234267.Acid_0084	2.725e-51	194.0	2EZNS@1|root,33STS@2|Bacteria,3Y75C@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_57	1049564.TevJSym_az00020	5.419e-11	74.0	COG1285@1|root,COG1285@2|Bacteria,1PD3I@1224|Proteobacteria,1RQXT@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
HKD1_k127_5042469_40	234267.Acid_0395	8.671e-41	162.0	COG2207@1|root,COG2207@2|Bacteria,3Y7NC@57723|Acidobacteria	57723|Acidobacteria	K	PFAM helix-turn-helix- domain containing protein, AraC type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD1_k127_5042469_49	1278073.MYSTI_04650	2.341e-25	113.0	2E902@1|root,3339H@2|Bacteria,1N9U6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_53	1303518.CCALI_00309	1.219e-19	96.0	COG2365@1|root,COG2365@2|Bacteria	2|Bacteria	T	protein tyrosine phosphatase activity	-	-	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	DSPc,DUF442,PTPlike_phytase,Y_phosphatase2,Y_phosphatase3
HKD1_k127_5042469_43	1297742.A176_03861	1.321e-37	151.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2YVU0@29|Myxococcales	28221|Deltaproteobacteria	T	Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
HKD1_k127_5042469_12	264732.Moth_2295	1.442e-108	367.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,42EU7@68295|Thermoanaerobacterales	186801|Clostridia	S	Extradiol ring-cleavage dioxygenase, class III	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
HKD1_k127_5042469_38	234267.Acid_4250	3.353e-46	183.0	COG0644@1|root,COG0644@2|Bacteria,3Y5JJ@57723|Acidobacteria	57723|Acidobacteria	C	TIGRFAM geranylgeranyl reductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Pyr_redox_2
HKD1_k127_5042469_33	1173028.ANKO01000170_gene3361	3.313e-49	181.0	COG0346@1|root,COG0346@2|Bacteria,1GAIM@1117|Cyanobacteria	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5042469_39	903818.KI912268_gene1040	1.471e-43	173.0	COG2214@1|root,COG2214@2|Bacteria	2|Bacteria	O	Heat shock protein DnaJ domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DNAJ_related,DUF4388,DnaJ
HKD1_k127_5042469_6	234267.Acid_0998	1.901e-193	612.0	COG2271@1|root,COG2271@2|Bacteria	2|Bacteria	G	transmembrane transporter activity	-	-	-	ko:K08196	-	-	-	-	ko00000,ko02000	2.A.1.15	-	-	MFS_1,Sugar_tr
HKD1_k127_5042469_29	472759.Nhal_1435	4.363e-57	205.0	COG2193@1|root,COG2193@2|Bacteria,1RF3C@1224|Proteobacteria,1S72I@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Ferritin-like domain	-	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD1_k127_5042469_50	748247.AZKH_1253	6.841e-25	110.0	2DPZY@1|root,3345E@2|Bacteria,1NC0H@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5042469_55	1265310.CCBD010000050_gene1947	9.663e-15	84.0	COG0500@1|root,COG2226@2|Bacteria,2IDZY@201174|Actinobacteria,237BP@1762|Mycobacteriaceae	201174|Actinobacteria	Q	Methionine biosynthesis protein MetW	metW	-	-	-	-	-	-	-	-	-	-	-	MetW,Methyltransf_11
HKD1_k127_5042469_32	768710.DesyoDRAFT_2109	5.746e-51	184.0	COG2050@1|root,COG2050@2|Bacteria,1VB47@1239|Firmicutes	1239|Firmicutes	Q	PFAM thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_5042469_16	518766.Rmar_0304	6.113e-92	312.0	COG1600@1|root,COG1600@2|Bacteria,4NFCJ@976|Bacteroidetes,1FJQT@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	4Fe-4S double cluster binding domain	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD1_k127_5042469_28	357808.RoseRS_0439	8.067e-60	216.0	COG0157@1|root,COG0157@2|Bacteria,2G6GJ@200795|Chloroflexi,375H1@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the NadC ModD family	-	-	2.4.2.19	ko:K00767	ko00760,ko01100,map00760,map01100	M00115	R03348	RC02877	ko00000,ko00001,ko00002,ko01000	-	-	-	QRPTase_C,QRPTase_N
HKD1_k127_5140315_53	402777.KB235903_gene2096	2.055e-22	108.0	COG2931@1|root,COG3291@1|root,COG2931@2|Bacteria,COG3291@2|Bacteria,1G3DW@1117|Cyanobacteria,1HAZM@1150|Oscillatoriales	1117|Cyanobacteria	Q	Domain of unknown function (DUF4347)	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4114,DUF4347,HemolysinCabind
HKD1_k127_5140315_49	373994.Riv7116_2631	1.097e-31	138.0	COG2931@1|root,COG2931@2|Bacteria,1G1I0@1117|Cyanobacteria,1HIHD@1161|Nostocales	1117|Cyanobacteria	Q	Hemolysin-type calcium-binding repeat (2 copies)	-	-	3.2.1.14	ko:K01183	ko00520,ko01100,map00520,map01100	-	R01206,R02334	RC00467	ko00000,ko00001,ko01000	-	GH18	-	Cadherin,Calx-beta,DUF4347,HemolysinCabind,Lectin_C,P_proprotein,Peptidase_S8,VWA
HKD1_k127_5140315_27	234267.Acid_4808	7.706e-73	256.0	COG0524@1|root,COG0524@2|Bacteria,3Y659@57723|Acidobacteria	57723|Acidobacteria	G	pfkB family carbohydrate kinase	-	-	2.7.1.184	ko:K18478	-	-	R10970	RC00002,RC00017	ko00000,ko01000	-	-	-	PfkB
HKD1_k127_5140315_5	1382359.JIAL01000001_gene2381	8.472e-191	614.0	COG0322@1|root,COG0322@2|Bacteria,3Y2Y7@57723|Acidobacteria,2JI6E@204432|Acidobacteriia	204432|Acidobacteriia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
HKD1_k127_5140315_29	1210045.ALNP01000024_gene562	5.17e-58	210.0	COG0596@1|root,COG0596@2|Bacteria,2GNFU@201174|Actinobacteria	201174|Actinobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_4,Abhydrolase_6
HKD1_k127_5140315_4	1118058.CAGY01000001_gene597	1.018e-194	619.0	COG0114@1|root,COG0114@2|Bacteria,2GKWY@201174|Actinobacteria,4D3ID@85005|Actinomycetales	201174|Actinobacteria	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD1_k127_5140315_28	1239962.C943_03620	8.122e-73	271.0	COG4447@1|root,COG4447@2|Bacteria,4NRP7@976|Bacteroidetes	976|Bacteroidetes	UW	protein related to plant photosystem II stability assembly factor	-	-	-	-	-	-	-	-	-	-	-	-	PSII_BNR
HKD1_k127_5140315_55	1348114.OM33_08730	8.395e-20	95.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,1S3YC@1236|Gammaproteobacteria,2Q1UP@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	GO:0003674,GO:0003676,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004523,GO:0004540,GO:0005488,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006271,GO:0006273,GO:0006401,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009057,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016787,GO:0016788,GO:0016891,GO:0016893,GO:0019439,GO:0022616,GO:0033567,GO:0034641,GO:0034645,GO:0034655,GO:0043137,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044260,GO:0044265,GO:0044270,GO:0046483,GO:0046700,GO:0071704,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0097159,GO:0140098,GO:1901360,GO:1901361,GO:1901363,GO:1901575,GO:1901576	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD1_k127_5140315_34	1340493.JNIF01000003_gene3968	1.029e-51	208.0	2FHMU@1|root,349FK@2|Bacteria,3Y8I3@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_1	240015.ACP_2643	1.288e-287	894.0	COG0481@1|root,COG0481@2|Bacteria,3Y3EX@57723|Acidobacteria,2JI4G@204432|Acidobacteriia	204432|Acidobacteriia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_5140315_2	1379698.RBG1_1C00001G0471	4.032e-217	685.0	COG1012@1|root,COG1012@2|Bacteria,2NNR8@2323|unclassified Bacteria	2|Bacteria	C	Belongs to the aldehyde dehydrogenase family	ycbD	-	1.2.1.3	ko:K00128,ko:K22187	ko00010,ko00040,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00040,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146,R11768	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_5140315_23	1340493.JNIF01000004_gene523	9.289e-80	287.0	COG0265@1|root,COG0265@2|Bacteria,3Y2SD@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase S1 and S6, chymotrypsin Hap	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_5140315_20	1267535.KB906767_gene5203	6.284e-88	301.0	COG1063@1|root,COG1063@2|Bacteria,3Y7C5@57723|Acidobacteria	57723|Acidobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HKD1_k127_5140315_60	452637.Oter_3126	2.564e-11	69.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	ccoP	-	-	ko:K00406,ko:K08906	ko00190,ko00195,ko01100,ko02020,map00190,map00195,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko00194	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD1_k127_5140315_7	1232410.KI421413_gene539	2.945e-177	568.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,42MDB@68525|delta/epsilon subdivisions,2WITV@28221|Deltaproteobacteria,43RZA@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Glutamine amidotransferases class-II	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD1_k127_5140315_44	1191523.MROS_2479	6.009e-41	160.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807,DUF4097
HKD1_k127_5140315_21	762903.Pedsa_1140	1.824e-86	301.0	COG0673@1|root,COG0673@2|Bacteria,4NFY3@976|Bacteroidetes	976|Bacteroidetes	E	Oxidoreductase NAD-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5140315_11	234267.Acid_4084	1.711e-138	455.0	COG2421@1|root,COG2421@2|Bacteria,3Y40F@57723|Acidobacteria	57723|Acidobacteria	C	PFAM Acetamidase Formamidase	-	-	-	-	-	-	-	-	-	-	-	-	FmdA_AmdA
HKD1_k127_5140315_51	317936.Nos7107_1630	8.071e-28	128.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Cu_amine_oxidN1
HKD1_k127_5140315_66	322710.Avin_10620	5.944e-06	57.0	COG0848@1|root,COG0848@2|Bacteria,1RDJZ@1224|Proteobacteria,1S3TA@1236|Gammaproteobacteria	1236|Gammaproteobacteria	U	Biopolymer transport protein	exbD	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	iPC815.YPO0683	ExbD
HKD1_k127_5140315_33	443143.GM18_0093	2.876e-53	195.0	COG3132@1|root,COG3132@2|Bacteria,1RA13@1224|Proteobacteria,42S8C@68525|delta/epsilon subdivisions,2WP10@28221|Deltaproteobacteria,43TU3@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function, DUF480	-	-	-	ko:K09915	-	-	-	-	ko00000	-	-	-	DUF480
HKD1_k127_5140315_64	929556.Solca_3593	3.247e-06	57.0	2F1U9@1|root,33UU9@2|Bacteria,4P2VQ@976|Bacteroidetes,1IXGS@117747|Sphingobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_40	1121935.AQXX01000092_gene3387	5.649e-44	165.0	COG3195@1|root,COG3195@2|Bacteria,1RIGR@1224|Proteobacteria,1S6QX@1236|Gammaproteobacteria,1XJXS@135619|Oceanospirillales	135619|Oceanospirillales	S	OHCU decarboxylase	-	-	4.1.1.97	ko:K16840	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06604	RC01551	ko00000,ko00001,ko00002,ko01000	-	-	-	OHCU_decarbox
HKD1_k127_5140315_47	1242864.D187_001061	9.098e-37	141.0	COG2351@1|root,COG2351@2|Bacteria,1RH84@1224|Proteobacteria,42W18@68525|delta/epsilon subdivisions,2X9WW@28221|Deltaproteobacteria,2YVN9@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily	-	-	3.5.2.17	ko:K07127	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R06601	RC03393	ko00000,ko00001,ko00002,ko01000,ko02000	9.B.35.1.2,9.B.35.2	-	-	Transthyretin
HKD1_k127_5140315_24	375286.mma_0514	7.485e-78	269.0	COG3748@1|root,COG3748@2|Bacteria,1MWHB@1224|Proteobacteria,2VIC0@28216|Betaproteobacteria,473XM@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HKD1_k127_5140315_39	926549.KI421517_gene500	5.634e-48	176.0	COG2947@1|root,COG2947@2|Bacteria,4NNQG@976|Bacteroidetes,47QAF@768503|Cytophagia	976|Bacteroidetes	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD1_k127_5140315_30	290512.Paes_0775	1.518e-57	204.0	COG1225@1|root,COG1225@2|Bacteria,1FDZX@1090|Chlorobi	1090|Chlorobi	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_5140315_48	1237149.C900_04030	1.862e-36	142.0	2DMMQ@1|root,32SHK@2|Bacteria,4NSZY@976|Bacteroidetes,47R9F@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3052
HKD1_k127_5140315_3	861299.J421_0708	3.299e-197	621.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	ko:K08178	-	-	-	-	ko00000,ko02000	2.A.1.12	-	-	MFS_1,Sugar_tr
HKD1_k127_5140315_14	521674.Plim_3769	8.336e-127	413.0	COG2041@1|root,COG2041@2|Bacteria,2J1J7@203682|Planctomycetes	203682|Planctomycetes	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide	msrP	-	-	ko:K07147	-	-	-	-	ko00000,ko01000	-	-	-	Oxidored_molyb
HKD1_k127_5140315_31	234267.Acid_7537	1.846e-57	206.0	COG2717@1|root,COG2717@2|Bacteria,3Y58Y@57723|Acidobacteria	57723|Acidobacteria	C	Part of the MsrPQ system that repairs oxidized cell envelope proteins containing methionine sulfoxide residues (Met- O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated cell envelope proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain	msrQ	-	-	ko:K17247	-	-	-	-	ko00000	-	-	-	Ferric_reduct
HKD1_k127_5140315_25	1396418.BATQ01000066_gene1615	1.327e-77	268.0	COG0500@1|root,COG2226@2|Bacteria,46V7Q@74201|Verrucomicrobia,2IWK1@203494|Verrucomicrobiae	203494|Verrucomicrobiae	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_5140315_17	886293.Sinac_2767	2.406e-105	349.0	COG1284@1|root,COG1284@2|Bacteria,2J1V7@203682|Planctomycetes	203682|Planctomycetes	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD1_k127_5140315_63	1079986.JH164882_gene2267	2.597e-06	53.0	COG1225@1|root,COG1225@2|Bacteria,2GKME@201174|Actinobacteria	201174|Actinobacteria	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	ahpE	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	AhpC-TSA
HKD1_k127_5140315_58	1340493.JNIF01000003_gene4158	1.687e-17	85.0	COG1225@1|root,COG1225@2|Bacteria	2|Bacteria	O	peroxiredoxin activity	-	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_5140315_26	247490.KSU1_D0503	8.413e-76	274.0	COG1651@1|root,COG1651@2|Bacteria	2|Bacteria	O	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD1_k127_5140315_6	1128421.JAGA01000002_gene991	4.07e-182	585.0	COG1793@1|root,COG1793@2|Bacteria,2NPKI@2323|unclassified Bacteria	2|Bacteria	L	ATP dependent DNA ligase C terminal region	lig	GO:0000287,GO:0003674,GO:0003824,GO:0003909,GO:0003910,GO:0005488,GO:0005575,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006266,GO:0006271,GO:0006273,GO:0006281,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016874,GO:0016886,GO:0022616,GO:0030312,GO:0033554,GO:0034641,GO:0034645,GO:0043167,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044424,GO:0044464,GO:0046483,GO:0046872,GO:0050896,GO:0051103,GO:0051716,GO:0071704,GO:0071944,GO:0090304,GO:0140097,GO:1901360,GO:1901576	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD1_k127_5140315_57	1157640.AQWO01000024_gene1590	3.913e-19	103.0	2DCKF@1|root,32TZU@2|Bacteria,2ITBZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_59	1296416.JACB01000033_gene2225	3.325e-17	96.0	COG3325@1|root,COG3979@1|root,COG3325@2|Bacteria,COG3979@2|Bacteria,4P27C@976|Bacteroidetes,1I0RB@117743|Flavobacteriia,2YJ1H@290174|Aquimarina	976|Bacteroidetes	G	Carbohydrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_19	525904.Tter_0241	1.084e-88	302.0	COG0614@1|root,COG0614@2|Bacteria	2|Bacteria	P	abc-type fe3 -hydroxamate transport system, periplasmic component	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_5140315_62	338963.Pcar_0093	1.377e-08	61.0	COG1826@1|root,COG1826@2|Bacteria,1NI3F@1224|Proteobacteria,42VIZ@68525|delta/epsilon subdivisions,2WRC5@28221|Deltaproteobacteria,43SSF@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	mttA/Hcf106 family	tatB	-	-	ko:K03116,ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_5140315_45	204669.Acid345_2680	6.225e-40	162.0	COG0805@1|root,COG0805@2|Bacteria,3Y3UC@57723|Acidobacteria,2JISU@204432|Acidobacteriia	204432|Acidobacteriia	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_5140315_9	234267.Acid_1509	5.356e-142	469.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_16	234267.Acid_1509	2.569e-106	365.0	COG4219@1|root,COG4219@2|Bacteria,3Y301@57723|Acidobacteria	57723|Acidobacteria	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_22	314278.NB231_00700	3.508e-82	285.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,1RMUI@1236|Gammaproteobacteria,1WWD4@135613|Chromatiales	135613|Chromatiales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD1_k127_5140315_56	344747.PM8797T_11454	1.225e-19	95.0	COG1331@1|root,COG4232@1|root,COG1331@2|Bacteria,COG4232@2|Bacteria,2IX0N@203682|Planctomycetes	203682|Planctomycetes	O	COG1331 Highly conserved protein containing a thioredoxin domain	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	DsbC,GlcNAc_2-epim,Thioredox_DsbH
HKD1_k127_5140315_46	519989.ECTPHS_07137	1.368e-37	147.0	COG1714@1|root,COG1714@2|Bacteria,1N1XF@1224|Proteobacteria,1SDY3@1236|Gammaproteobacteria,1WZR8@135613|Chromatiales	135613|Chromatiales	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_5140315_38	1200557.JHWV01000006_gene1883	4.02e-48	184.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,4H26Q@909932|Negativicutes	909932|Negativicutes	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_5140315_52	936550.HMPREF1492_0556	8.827e-26	111.0	COG0736@1|root,COG0736@2|Bacteria,2HT7V@201174|Actinobacteria,4CVSA@84998|Coriobacteriia	84998|Coriobacteriia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_5140315_12	204669.Acid345_1065	3.219e-137	467.0	COG0744@1|root,COG0744@2|Bacteria,3Y42I@57723|Acidobacteria,2JI7Q@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05365	ko00550,map00550	-	R04519	RC00005,RC00049	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_5140315_35	748449.Halha_1430	9.54e-51	190.0	COG1752@1|root,COG1752@2|Bacteria,1UUVB@1239|Firmicutes,24HQS@186801|Clostridia,3WAJH@53433|Halanaerobiales	186801|Clostridia	S	PFAM Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_5140315_50	639030.JHVA01000001_gene1123	6.128e-29	129.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_5140315_32	1267535.KB906767_gene1046	9.005e-56	208.0	COG2885@1|root,COG2885@2|Bacteria	2|Bacteria	M	chlorophyll binding	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,OmpA,PD40
HKD1_k127_5140315_13	861299.J421_3595	1.122e-132	438.0	COG0508@1|root,COG0508@2|Bacteria,1ZT7I@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD1_k127_5140315_42	1121451.DESAM_21635	5.57e-42	156.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,42U4W@68525|delta/epsilon subdivisions,2WQ9S@28221|Deltaproteobacteria,2MCV4@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HKD1_k127_5140315_10	234267.Acid_0353	7.282e-140	451.0	COG0022@1|root,COG0022@2|Bacteria,3Y48G@57723|Acidobacteria	57723|Acidobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_5140315_54	1123508.JH636440_gene2314	3.891e-20	97.0	COG3012@1|root,COG3012@2|Bacteria,2J3YW@203682|Planctomycetes	203682|Planctomycetes	S	SEC-C Motif Domain Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_15	861299.J421_3598	1.154e-108	363.0	COG1071@1|root,COG1071@2|Bacteria,1ZT5G@142182|Gemmatimonadetes	2|Bacteria	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	bfmBA	-	1.2.4.1,1.2.4.4	ko:K00161,ko:K11381,ko:K21416	ko00010,ko00020,ko00280,ko00620,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00280,map00620,map00640,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00036,M00307	R00014,R00209,R01699,R03270,R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00004,RC00027,RC00627,RC02742,RC02743,RC02744,RC02882,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_5140315_8	378806.STAUR_4671	4.032e-171	550.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,42N8Y@68525|delta/epsilon subdivisions,2WIR7@28221|Deltaproteobacteria,2YTYX@29|Myxococcales	28221|Deltaproteobacteria	C	dihydrolipoamide dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_5140315_43	195250.CM001776_gene1550	2.369e-41	156.0	COG0607@1|root,COG0607@2|Bacteria,1GPXG@1117|Cyanobacteria,1H0XW@1129|Synechococcus	1117|Cyanobacteria	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_5140315_36	1121920.AUAU01000009_gene1864	1.845e-49	199.0	COG0457@1|root,COG0457@2|Bacteria,3Y5YE@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5140315_0	886293.Sinac_4730	0.0	1285.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2IX33@203682|Planctomycetes	203682|Planctomycetes	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_5140315_18	497964.CfE428DRAFT_2318	3.529e-105	353.0	COG0664@1|root,COG4420@1|root,COG0664@2|Bacteria,COG4420@2|Bacteria,46T5T@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Protein of unknown function (DUF1003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1003,cNMP_binding
HKD1_k127_5140315_41	1382359.JIAL01000001_gene1085	1.406e-42	172.0	COG2304@1|root,COG2304@2|Bacteria,3Y483@57723|Acidobacteria,2JI1N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_5141751_0	760568.Desku_2097	8.682e-122	402.0	COG0438@1|root,COG0438@2|Bacteria,1TR0Y@1239|Firmicutes,24B5E@186801|Clostridia,265TC@186807|Peptococcaceae	186801|Clostridia	M	Domain of unknown function (DUF1972)	-	-	-	ko:K12996	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_5149119_28	483219.LILAB_29585	2.878e-40	166.0	COG2850@1|root,COG2850@2|Bacteria,1QANN@1224|Proteobacteria,43572@68525|delta/epsilon subdivisions,2WZI3@28221|Deltaproteobacteria,2Z274@29|Myxococcales	28221|Deltaproteobacteria	S	peptidyl-arginine hydroxylation	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_4
HKD1_k127_5149119_33	1173026.Glo7428_3559	1.232e-24	115.0	COG1453@1|root,COG1453@2|Bacteria,1G4DD@1117|Cyanobacteria	1117|Cyanobacteria	S	SPTR Oxidoreductase of the aldo keto reductase family-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_5149119_2	118173.KB235914_gene1551	2.644e-229	745.0	COG2274@1|root,COG2274@2|Bacteria,1FZZ2@1117|Cyanobacteria,1H760@1150|Oscillatoriales	1117|Cyanobacteria	V	N-terminal double-glycine peptidase domain	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran,Peptidase_C39,cNMP_binding
HKD1_k127_5149119_10	335543.Sfum_0593	1.538e-126	415.0	COG0628@1|root,COG0628@2|Bacteria,1MVX7@1224|Proteobacteria,42S7F@68525|delta/epsilon subdivisions,2WK0P@28221|Deltaproteobacteria,2MS10@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Pfam:UPF0118	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_5149119_44	204669.Acid345_1765	5.992e-06	53.0	COG1366@1|root,COG1366@2|Bacteria,3Y4U6@57723|Acidobacteria,2JJH2@204432|Acidobacteriia	204432|Acidobacteriia	T	Belongs to the anti-sigma-factor antagonist family	-	-	-	ko:K04749	-	-	-	-	ko00000,ko03021	-	-	-	STAS
HKD1_k127_5149119_22	1267535.KB906767_gene277	4.956e-59	208.0	2DB97@1|root,33TRP@2|Bacteria,3Y7NY@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5149119_8	234267.Acid_1154	2.857e-168	562.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y3FE@57723|Acidobacteria	2|Bacteria	KU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_5149119_31	765420.OSCT_2742	7.502e-30	130.0	COG1262@1|root,COG1262@2|Bacteria	2|Bacteria	T	PFAM Formylglycine-generating sulfatase enzyme	-	-	1.14.99.50	ko:K18912	ko00340,map00340	-	R11013	RC03323,RC03324	ko00000,ko00001,ko01000	-	-	-	FGE-sulfatase,Pkinase
HKD1_k127_5149119_36	404589.Anae109_0240	2.124e-18	87.0	COG0493@1|root,COG1145@1|root,COG0493@2|Bacteria,COG1145@2|Bacteria,1MU2H@1224|Proteobacteria,42MGY@68525|delta/epsilon subdivisions,2WKB4@28221|Deltaproteobacteria,2YTUD@29|Myxococcales	28221|Deltaproteobacteria	C	Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD1_k127_5149119_46	1382306.JNIM01000001_gene3379	2.064e-05	51.0	COG0493@1|root,COG0493@2|Bacteria	2|Bacteria	C	'glutamate synthase	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_20,Pyr_redox_2
HKD1_k127_5149119_24	383372.Rcas_0814	1.466e-53	200.0	294HY@1|root,2ZRXK@2|Bacteria,2GAIJ@200795|Chloroflexi,376D9@32061|Chloroflexia	32061|Chloroflexia	S	YwiC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YwiC
HKD1_k127_5149119_5	1207063.P24_05304	5.886e-181	571.0	COG4948@1|root,COG4948@2|Bacteria,1MU8R@1224|Proteobacteria,2U0W7@28211|Alphaproteobacteria,2JW88@204441|Rhodospirillales	204441|Rhodospirillales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD1_k127_5149119_32	1042377.AFPJ01000024_gene743	3.02e-29	129.0	COG2199@1|root,COG3706@2|Bacteria,1MWHH@1224|Proteobacteria,1RRU7@1236|Gammaproteobacteria,465TD@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	7TMR-DISM extracellular 2	-	-	-	-	-	-	-	-	-	-	-	-	7TMR-DISMED2,7TMR-DISM_7TM,GGDEF
HKD1_k127_5149119_1	204669.Acid345_2969	1.728e-245	786.0	COG0204@1|root,COG1022@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,3Y3GW@57723|Acidobacteria,2JHKK@204432|Acidobacteriia	204432|Acidobacteriia	I	Phosphate acyltransferases	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,PP-binding
HKD1_k127_5149119_30	240015.ACP_0219	1.073e-31	139.0	COG0457@1|root,COG0457@2|Bacteria,3Y3JH@57723|Acidobacteria,2JI8K@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_5149119_34	240015.ACP_1394	3.958e-23	116.0	COG3534@1|root,COG4625@1|root,COG3534@2|Bacteria,COG4625@2|Bacteria,3Y354@57723|Acidobacteria,2JKXY@204432|Acidobacteriia	204432|Acidobacteriia	N	Putative Ig domain	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG
HKD1_k127_5149119_41	305700.B447_04522	6.155e-08	66.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,2VSYA@28216|Betaproteobacteria,2KZK9@206389|Rhodocyclales	206389|Rhodocyclales	M	O-antigen ligase like membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD1_k127_5149119_40	240016.ABIZ01000001_gene4253	6.619e-10	70.0	COG2898@1|root,COG2898@2|Bacteria,46ZGD@74201|Verrucomicrobia,2IUPX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Uncharacterised conserved protein (DUF2156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2156,VirJ
HKD1_k127_5149119_45	1396141.BATP01000019_gene1705	6.343e-06	58.0	COG2898@1|root,COG2898@2|Bacteria,46ZGD@74201|Verrucomicrobia,2IUPX@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	Uncharacterised conserved protein (DUF2156)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2156,VirJ
HKD1_k127_5149119_21	903814.ELI_3698	3.883e-63	232.0	COG2898@1|root,COG2898@2|Bacteria,1TQI2@1239|Firmicutes,24BRW@186801|Clostridia,25Y73@186806|Eubacteriaceae	186801|Clostridia	S	Uncharacterised conserved protein (DUF2156)	mprF	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HKD1_k127_5149119_42	391596.PBAL39_25370	2.289e-07	62.0	COG1506@1|root,COG3946@1|root,COG1506@2|Bacteria,COG3946@2|Bacteria,4NRNY@976|Bacteroidetes,1J173@117747|Sphingobacteriia	976|Bacteroidetes	EU	Bacterial virulence protein (VirJ)	-	-	-	-	-	-	-	-	-	-	-	-	VirJ
HKD1_k127_5149119_39	1116369.KB890024_gene2505	5.233e-11	70.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,2UEND@28211|Alphaproteobacteria,43KD4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_5149119_25	443143.GM18_1368	1.183e-51	203.0	COG4191@1|root,COG4191@2|Bacteria,1R9AK@1224|Proteobacteria,42Q2G@68525|delta/epsilon subdivisions,2WM8Y@28221|Deltaproteobacteria,43RXW@69541|Desulfuromonadales	28221|Deltaproteobacteria	T	histidine kinase, HAMP	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_5149119_11	429009.Adeg_0173	2.846e-115	386.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,42J66@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02481,ko:K07714,ko:K10943	ko02020,ko05111,map02020,map05111	M00500,M00515	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_5149119_17	7918.ENSLOCP00000006825	5.466e-82	280.0	COG0434@1|root,2QUBS@2759|Eukaryota,38EZC@33154|Opisthokonta,3BES3@33208|Metazoa,3D0S4@33213|Bilateria,47ZQG@7711|Chordata,4905V@7742|Vertebrata,49RCN@7898|Actinopterygii	33208|Metazoa	S	Zgc 162297	-	-	-	ko:K06971	-	-	-	-	ko00000	-	-	-	BtpA
HKD1_k127_5149119_27	1123278.KB893580_gene892	7.323e-41	167.0	COG0500@1|root,COG2226@2|Bacteria,4NIN6@976|Bacteroidetes,47JAJ@768503|Cytophagia	976|Bacteroidetes	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Ubie_methyltran
HKD1_k127_5149119_26	936455.KI421499_gene7790	3.728e-47	178.0	COG2215@1|root,COG2215@2|Bacteria,1R3QK@1224|Proteobacteria,2U11V@28211|Alphaproteobacteria,3JSYD@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Belongs to the NiCoT transporter (TC 2.A.52) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5149119_23	1487953.JMKF01000053_gene1867	3.207e-55	196.0	COG0346@1|root,COG0346@2|Bacteria,1GE06@1117|Cyanobacteria	1117|Cyanobacteria	E	PFAM Glyoxalase Bleomycin resistance protein Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5149119_20	234267.Acid_3287	4.228e-64	224.0	COG5485@1|root,COG5485@2|Bacteria,3Y5VH@57723|Acidobacteria	57723|Acidobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_5149119_7	1123508.JH636445_gene6793	9.984e-176	558.0	COG2141@1|root,COG2141@2|Bacteria,2J10P@203682|Planctomycetes	203682|Planctomycetes	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD1_k127_5149119_9	1210884.HG799465_gene11589	1.184e-138	449.0	COG0189@1|root,COG0189@2|Bacteria,2J20G@203682|Planctomycetes	203682|Planctomycetes	HJ	RimK-like ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	RimK
HKD1_k127_5149119_35	471854.Dfer_0259	3.987e-19	88.0	2EIK5@1|root,33CBF@2|Bacteria,4NV2P@976|Bacteroidetes,47T4T@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5149119_4	518766.Rmar_1548	4.57e-182	587.0	COG1086@1|root,COG1086@2|Bacteria	2|Bacteria	GM	Polysaccharide biosynthesis protein	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf,CoA_binding_3,Glycos_transf_4,HTH_45,LicD
HKD1_k127_5149119_3	1267533.KB906733_gene2857	3.59e-182	577.0	COG1262@1|root,COG1262@2|Bacteria,3Y4J6@57723|Acidobacteria	57723|Acidobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD1_k127_5149119_0	234267.Acid_0882	4.673e-268	836.0	COG0154@1|root,COG0154@2|Bacteria,3Y2N6@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD1_k127_5149119_29	153721.MYP_1271	9.218e-32	147.0	COG5492@1|root,COG5492@2|Bacteria,4PKMF@976|Bacteroidetes,47QU9@768503|Cytophagia	976|Bacteroidetes	N	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5149119_37	985053.VMUT_1519	1.362e-17	88.0	COG1917@1|root,arCOG02999@2157|Archaea	2157|Archaea	S	conserved protein, contains double-stranded beta-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5149119_14	234267.Acid_2736	2.531e-108	357.0	COG3718@1|root,COG3718@2|Bacteria	2|Bacteria	G	enzyme involved in inositol metabolism	iolB	-	5.3.1.30	ko:K03337	ko00562,ko01100,ko01120,map00562,map01100,map01120	-	R08503	RC00541	ko00000,ko00001,ko01000	-	-	-	KduI
HKD1_k127_5149119_12	1101189.AQUO01000001_gene1998	9.212e-112	379.0	COG2721@1|root,COG2721@2|Bacteria,1MU9V@1224|Proteobacteria,2TTDT@28211|Alphaproteobacteria,2PV4X@265|Paracoccus	28211|Alphaproteobacteria	G	D-galactarate dehydratase / Altronate hydrolase, C terminus	MA20_16205	-	4.2.1.7	ko:K01685	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C,SAF
HKD1_k127_5149119_15	1492738.FEM21_11630	1.087e-100	338.0	COG0363@1|root,COG0363@2|Bacteria,4PB68@976|Bacteroidetes,1ICNY@117743|Flavobacteriia,2NTX7@237|Flavobacterium	976|Bacteroidetes	G	glucosamine-6-phosphate deaminase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5149119_13	1382359.JIAL01000001_gene1348	1.003e-109	361.0	COG1028@1|root,COG1028@2|Bacteria,3Y3CD@57723|Acidobacteria,2JHIF@204432|Acidobacteriia	204432|Acidobacteriia	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_5149119_6	1267534.KB906756_gene262	2.849e-176	559.0	COG0524@1|root,COG0524@2|Bacteria,3Y3DE@57723|Acidobacteria,2JI9I@204432|Acidobacteriia	204432|Acidobacteriia	G	pfkB family carbohydrate kinase	-	-	2.7.1.45	ko:K00874	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00061,M00308,M00631	R01541	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PfkB
HKD1_k127_5149119_18	682795.AciX8_3658	9.234e-74	256.0	COG0800@1|root,COG0800@2|Bacteria,3Y4HZ@57723|Acidobacteria,2JKJ9@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM KDPG and KHG aldolase	-	-	4.1.2.14,4.1.3.42	ko:K01625	ko00030,ko00630,ko01100,ko01120,ko01200,map00030,map00630,map01100,map01120,map01200	M00008,M00061,M00308,M00631	R00470,R05605	RC00307,RC00308,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HKD1_k127_5149119_19	1267534.KB906754_gene3005	9.913e-69	241.0	COG2186@1|root,COG2186@2|Bacteria,3Y47U@57723|Acidobacteria,2JI8P@204432|Acidobacteriia	204432|Acidobacteriia	K	FCD	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD1_k127_5149119_16	450851.PHZ_c2461	2.647e-87	296.0	COG5434@1|root,COG5434@2|Bacteria,1MXP8@1224|Proteobacteria,2TVCM@28211|Alphaproteobacteria,2KHU2@204458|Caulobacterales	204458|Caulobacterales	G	Belongs to the glycosyl hydrolase 28 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_28
HKD1_k127_5184943_2	1144275.COCOR_03695	1.295e-60	239.0	COG3055@1|root,COG3055@2|Bacteria,1QA41@1224|Proteobacteria,43DXI@68525|delta/epsilon subdivisions,2X90U@28221|Deltaproteobacteria,2Z1C1@29|Myxococcales	28221|Deltaproteobacteria	M	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5184943_6	251221.35213566	8.058e-23	116.0	COG1404@1|root,COG5549@1|root,COG1404@2|Bacteria,COG5549@2|Bacteria,1G72X@1117|Cyanobacteria	1117|Cyanobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5184943_7	1121948.AUAC01000008_gene796	1.062e-22	115.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria,43ZJT@69657|Hyphomonadaceae	28211|Alphaproteobacteria	Q	Haemolysin-type calcium-binding repeat (2 copies)	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind
HKD1_k127_5184943_8	1298608.JCM18900_1754	5.213e-22	113.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,1RMCY@1236|Gammaproteobacteria,3NJZ9@468|Moraxellaceae	1236|Gammaproteobacteria	U	Involved in the TonB-independent uptake of proteins	tolB	GO:0003674,GO:0005215,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0006810,GO:0008104,GO:0008150,GO:0009719,GO:0009987,GO:0010033,GO:0010243,GO:0015031,GO:0015833,GO:0015893,GO:0017038,GO:0019904,GO:0030288,GO:0030313,GO:0031975,GO:0032153,GO:0032991,GO:0033036,GO:0042221,GO:0042493,GO:0042597,GO:0042886,GO:0042891,GO:0043213,GO:0044464,GO:0044877,GO:0045184,GO:0046677,GO:0046678,GO:0050896,GO:0051179,GO:0051234,GO:0051716,GO:0070887,GO:0071236,GO:0071237,GO:0071310,GO:0071417,GO:0071495,GO:0071702,GO:0071705,GO:1901652,GO:1901653,GO:1901698,GO:1901699,GO:1901700,GO:1901701	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD1_k127_5184943_5	671143.DAMO_3107	3.838e-39	170.0	COG0265@1|root,COG4625@1|root,COG0265@2|Bacteria,COG4625@2|Bacteria	2|Bacteria	T	pathogenesis	-	-	3.4.21.107,3.4.21.50	ko:K01337,ko:K04771,ko:K20276,ko:K21449	ko01503,ko02020,ko02024,map01503,map02020,map02024	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko02000,ko03110	1.B.40.2	-	-	Autotransporter,Big_3_5,Cadherin-like,Calx-beta,DUF4347,He_PIG,PATR,TIG
HKD1_k127_5184943_4	1157490.EL26_16530	7.658e-42	160.0	COG0817@1|root,COG0817@2|Bacteria,1V3N9@1239|Firmicutes,4HGM3@91061|Bacilli,279QS@186823|Alicyclobacillaceae	91061|Bacilli	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD1_k127_5184943_1	204669.Acid345_2125	2.314e-99	329.0	COG0217@1|root,COG0217@2|Bacteria,3Y2UW@57723|Acidobacteria,2JIJW@204432|Acidobacteriia	204432|Acidobacteriia	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD1_k127_5184943_0	1267533.KB906735_gene4448	1.158e-198	654.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_17
HKD1_k127_5184943_9	517418.Ctha_0036	1.889e-19	92.0	COG1872@1|root,COG1872@2|Bacteria,1FE84@1090|Chlorobi	1090|Chlorobi	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD1_k127_5184943_10	1123401.JHYQ01000026_gene3236	6.987e-11	71.0	COG0762@1|root,COG0762@2|Bacteria,1RCZV@1224|Proteobacteria,1S6DW@1236|Gammaproteobacteria,4615R@72273|Thiotrichales	72273|Thiotrichales	S	YGGT family	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD1_k127_5184943_3	1232410.KI421412_gene206	5.985e-59	213.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,42PSG@68525|delta/epsilon subdivisions,2WKYN@28221|Deltaproteobacteria,43TVQ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	yggS	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD1_k127_5194179_5	1040987.AZUY01000002_gene3689	1.092e-47	183.0	COG0583@1|root,COG0583@2|Bacteria,1R55T@1224|Proteobacteria,2U445@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_5194179_1	379066.GAU_1288	8.925e-84	291.0	COG1402@1|root,COG1402@2|Bacteria	2|Bacteria	I	creatininase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_5194179_6	1384054.N790_13360	4.468e-34	137.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,1S5XS@1236|Gammaproteobacteria,1X6CE@135614|Xanthomonadales	135614|Xanthomonadales	J	endoribonuclease	yjgF	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_5194179_8	639030.JHVA01000001_gene3295	1.681e-26	115.0	COG0384@1|root,COG0384@2|Bacteria,3Y4H0@57723|Acidobacteria,2JJ47@204432|Acidobacteriia	204432|Acidobacteriia	S	Phenazine biosynthesis protein, PhzF family	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_5194179_2	452637.Oter_1936	7.497e-82	286.0	COG0582@1|root,COG0582@2|Bacteria,46TD6@74201|Verrucomicrobia,3K9G2@414999|Opitutae	414999|Opitutae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_5194179_0	497964.CfE428DRAFT_4167	2.837e-102	337.0	COG1208@1|root,COG1208@2|Bacteria,46SP1@74201|Verrucomicrobia	74201|Verrucomicrobia	JM	Bacterial transferase hexapeptide (six repeats)	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_5194179_4	1121373.KB903622_gene2860	9.818e-66	232.0	2DKXV@1|root,30THP@2|Bacteria,4NS65@976|Bacteroidetes,47WGS@768503|Cytophagia	976|Bacteroidetes	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_2
HKD1_k127_5194179_10	1267535.KB906767_gene5189	5.475e-05	52.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_5194179_7	631362.Thi970DRAFT_02030	1.23e-26	120.0	COG1226@1|root,32Y28@2|Bacteria,1NEAT@1224|Proteobacteria,1S588@1236|Gammaproteobacteria,1WZEG@135613|Chromatiales	135613|Chromatiales	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_5197982_0	1205910.B005_1787	3.081e-253	789.0	COG0318@1|root,COG0318@2|Bacteria,2GIUC@201174|Actinobacteria,4EG29@85012|Streptosporangiales	201174|Actinobacteria	IQ	AMP-binding enzyme C-terminal domain	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_5197982_2	997346.HMPREF9374_0432	7.837e-57	212.0	COG0492@1|root,COG0492@2|Bacteria,1TQGS@1239|Firmicutes,4HBIS@91061|Bacilli,27B3R@186824|Thermoactinomycetaceae	91061|Bacilli	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_3
HKD1_k127_5197982_1	330214.NIDE2777	3.963e-58	214.0	COG0384@1|root,COG0384@2|Bacteria	2|Bacteria	S	isomerase activity	yddE	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD1_k127_5197982_3	1254432.SCE1572_16555	4.458e-45	172.0	COG3571@1|root,COG3571@2|Bacteria,1RD20@1224|Proteobacteria,42SGK@68525|delta/epsilon subdivisions,2WPDI@28221|Deltaproteobacteria,2YVW1@29|Myxococcales	28221|Deltaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	ko:K07020	-	-	-	-	ko00000	-	-	-	Abhydrolase_4,Abhydrolase_5,DLH
HKD1_k127_5197982_4	1267535.KB906767_gene2521	5.153e-42	159.0	294EW@1|root,2ZRUR@2|Bacteria,3Y5CG@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1569)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1569
HKD1_k127_5241654_2	269797.Mbar_A2782	1.285e-109	366.0	COG1520@1|root,COG1572@1|root,COG3291@1|root,arCOG02516@1|root,arCOG02492@2157|Archaea,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02532@2157|Archaea,2Y7Q0@28890|Euryarchaeota	28890|Euryarchaeota	KLT	COG1520 FOG WD40-like repeat	-	-	-	-	-	-	-	-	-	-	-	-	PKD,PQQ_3
HKD1_k127_5241654_8	1089547.KB913013_gene4601	6.463e-25	115.0	2CSRV@1|root,32SRR@2|Bacteria,4NTI6@976|Bacteroidetes,47VM9@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NlpE
HKD1_k127_5241654_0	234267.Acid_7301	6.35e-255	799.0	COG3250@1|root,COG3250@2|Bacteria,3Y32Q@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.31	ko:K01195	ko00040,ko00531,ko00860,ko00944,ko00983,ko01100,ko01110,ko04142,map00040,map00531,map00860,map00944,map00983,map01100,map01110,map04142	M00014,M00076,M00077,M00078,M00129	R01478,R04979,R07818,R08127,R08260,R10830	RC00055,RC00171,RC00529,RC00530,RC00714,RC01251	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_5241654_1	379066.GAU_3265	4.296e-158	510.0	COG0666@1|root,COG0666@2|Bacteria	2|Bacteria	G	response to abiotic stimulus	-	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	AAA_19,Ank,Ank_2,Ank_3,Ank_4,Ank_5,Sigma70_r2,Sigma70_r4,Viral_helicase1
HKD1_k127_5241654_7	1122604.JONR01000071_gene4517	7.234e-54	194.0	COG3795@1|root,COG3795@2|Bacteria,1N36T@1224|Proteobacteria,1SP16@1236|Gammaproteobacteria,1X872@135614|Xanthomonadales	135614|Xanthomonadales	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_5241654_3	639030.JHVA01000001_gene2523	7.614e-98	322.0	COG0262@1|root,COG0262@2|Bacteria,3Y6JH@57723|Acidobacteria,2JKMV@204432|Acidobacteriia	204432|Acidobacteriia	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_5241654_6	204669.Acid345_3072	2.454e-61	213.0	COG3795@1|root,COG3795@2|Bacteria,3Y89G@57723|Acidobacteria,2JNCT@204432|Acidobacteriia	204432|Acidobacteriia	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_5241654_4	762903.Pedsa_0641	6.766e-71	245.0	COG0262@1|root,COG0262@2|Bacteria,4NMP3@976|Bacteroidetes	976|Bacteroidetes	H	Pfam RibD C-terminal domain	-	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C
HKD1_k127_5241654_5	1267533.KB906737_gene1697	9.051e-63	220.0	COG3795@1|root,COG3795@2|Bacteria,3Y4T8@57723|Acidobacteria	57723|Acidobacteria	S	YCII-related domain	-	-	-	-	-	-	-	-	-	-	-	-	YCII
HKD1_k127_5241654_9	1198114.AciX9_3231	1.096e-19	93.0	COG0346@1|root,COG0346@2|Bacteria,3Y5G5@57723|Acidobacteria,2JJZG@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5279605_9	1297742.A176_06965	7.403e-28	113.0	COG5470@1|root,COG5470@2|Bacteria,1N7JA@1224|Proteobacteria,4358I@68525|delta/epsilon subdivisions,2WZJK@28221|Deltaproteobacteria,2Z29U@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF1330)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1330
HKD1_k127_5279605_13	671143.DAMO_0870	4.62e-12	78.0	COG0741@1|root,COG0741@2|Bacteria	2|Bacteria	M	lytic transglycosylase activity	-	-	-	ko:K03194	ko03070,map03070	M00333	-	-	ko00000,ko00001,ko00002,ko02044	-	-	-	CHAP,SLT
HKD1_k127_5279605_0	1379698.RBG1_1C00001G1471	7.208e-246	769.0	COG4799@1|root,COG4799@2|Bacteria,2NNWQ@2323|unclassified Bacteria	2|Bacteria	I	carboxyl transferase	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_5279605_7	1121413.JMKT01000011_gene2225	1.089e-40	160.0	COG0842@1|root,COG0842@2|Bacteria,1N55T@1224|Proteobacteria,42N8F@68525|delta/epsilon subdivisions,2WK3B@28221|Deltaproteobacteria,2MA60@213115|Desulfovibrionales	28221|Deltaproteobacteria	V	PFAM ABC-2 type transporter	-	-	-	ko:K09694	ko02010,map02010	M00252	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.102	-	-	ABC2_membrane
HKD1_k127_5279605_5	234267.Acid_2539	1.362e-47	184.0	2DJMQ@1|root,32UDD@2|Bacteria,3Y57W@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5279605_6	234267.Acid_2537	2.861e-44	168.0	COG1595@1|root,COG1595@2|Bacteria,3Y5RY@57723|Acidobacteria	57723|Acidobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_5279605_11	702450.CUW_2845	3.585e-15	81.0	COG3557@1|root,COG3557@2|Bacteria,1TRX8@1239|Firmicutes,3VQ9A@526524|Erysipelotrichia	526524|Erysipelotrichia	J	Psort location Cytoplasmic, score	-	-	-	ko:K07586	-	-	-	-	ko00000	-	-	-	DUF402
HKD1_k127_5279605_2	562970.Btus_0343	3.512e-83	287.0	COG1131@1|root,COG1131@2|Bacteria,1TPMQ@1239|Firmicutes,4HDH1@91061|Bacilli	91061|Bacilli	V	abc transporter atp-binding protein	drrA	-	-	ko:K01990,ko:K09695	ko02010,map02010	M00252,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.102	-	-	ABC_tran
HKD1_k127_5279605_3	518766.Rmar_0473	2.271e-81	278.0	COG0176@1|root,COG0176@2|Bacteria,4NFVZ@976|Bacteroidetes,1FK0R@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	H	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616,ko:K08314	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_5279605_8	1045855.DSC_06015	7.223e-37	156.0	2AQ2A@1|root,31F7E@2|Bacteria,1QCMG@1224|Proteobacteria,1T8CS@1236|Gammaproteobacteria,1XAFU@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5279605_10	204669.Acid345_0196	1.565e-27	125.0	COG4733@1|root,COG4733@2|Bacteria,3Y53H@57723|Acidobacteria,2JJMD@204432|Acidobacteriia	204432|Acidobacteriia	S	Fibronectin type 3 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5279605_1	204669.Acid345_0212	1.828e-209	660.0	COG1220@1|root,COG1220@2|Bacteria,3Y2K2@57723|Acidobacteria,2JIS7@204432|Acidobacteriia	204432|Acidobacteriia	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD1_k127_5279605_4	1382359.JIAL01000001_gene1358	5.306e-73	250.0	COG5405@1|root,COG5405@2|Bacteria,3Y42U@57723|Acidobacteria,2JIR7@204432|Acidobacteriia	204432|Acidobacteriia	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD1_k127_5279605_14	1382306.JNIM01000001_gene3921	4.396e-11	68.0	COG2071@1|root,COG2071@2|Bacteria,2G6QN@200795|Chloroflexi	200795|Chloroflexi	S	PFAM glutamine amidotransferase class-I	-	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD1_k127_5289387_2	1340493.JNIF01000003_gene3450	3.596e-38	151.0	COG1802@1|root,COG1802@2|Bacteria,3Y849@57723|Acidobacteria	57723|Acidobacteria	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_5289387_0	1128421.JAGA01000002_gene1474	0.0	1017.0	COG1028@1|root,COG3347@1|root,COG1028@2|Bacteria,COG3347@2|Bacteria,2NQGA@2323|unclassified Bacteria	2|Bacteria	IQ	Class II Aldolase and Adducin N-terminal domain	rhaD	-	1.1.1.1,4.1.2.19	ko:K00001,ko:K01629	ko00010,ko00040,ko00051,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00040,map00051,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R01785,R02124,R02263,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00438,RC00599,RC00603,RC00604,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	Aldolase_II,adh_short_C2
HKD1_k127_5289387_1	189753.AXAS01000043_gene4988	1.226e-61	217.0	COG4952@1|root,COG4952@2|Bacteria,1PSSV@1224|Proteobacteria,2TSCI@28211|Alphaproteobacteria,3JWBH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	isomerase	rhaI	-	5.3.1.14	ko:K01820	ko00040,ko00051,ko01120,map00040,map00051,map01120	-	R01906,R02437,R06589	RC00376,RC00434,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_5329304_7	1463900.JOIX01000025_gene5795	6.274e-33	141.0	28JBD@1|root,2Z964@2|Bacteria,2H0C3@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5329304_0	269799.Gmet_1194	3.491e-158	542.0	2DB7D@1|root,2Z7KR@2|Bacteria,1Q0FB@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5329304_10	746697.Aeqsu_0043	3.093e-05	54.0	COG5661@1|root,COG5661@2|Bacteria,4NW11@976|Bacteroidetes,1I32R@117743|Flavobacteriia	976|Bacteroidetes	O	secreted Zn-dependent protease	-	-	-	-	-	-	-	-	-	-	-	-	DUF922
HKD1_k127_5329304_6	82654.Pse7367_0121	1.676e-50	196.0	COG2931@1|root,COG2931@2|Bacteria,1G67W@1117|Cyanobacteria,1HASU@1150|Oscillatoriales	1117|Cyanobacteria	Q	Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,HemolysinCabind
HKD1_k127_5329304_8	748247.AZKH_1177	6.073e-30	128.0	2D2IW@1|root,32TCX@2|Bacteria,1N4MH@1224|Proteobacteria,2W1UY@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Protein of unknown function (DUF1353)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1353
HKD1_k127_5329304_5	572547.Amico_1593	2.128e-63	222.0	COG2110@1|root,COG2110@2|Bacteria,3TBCJ@508458|Synergistetes	508458|Synergistetes	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Macro
HKD1_k127_5329304_4	1173026.Glo7428_0383	2.153e-76	264.0	COG0259@1|root,COG0259@2|Bacteria,1G0HC@1117|Cyanobacteria	1117|Cyanobacteria	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.pdxH	PNP_phzG_C,Putative_PNPOx
HKD1_k127_5329304_1	1396418.BATQ01000091_gene5776	2.108e-148	479.0	COG0079@1|root,COG0079@2|Bacteria,46SFP@74201|Verrucomicrobia,2ITIN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	E	Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_5329304_2	497964.CfE428DRAFT_4709	1.164e-142	467.0	COG0486@1|root,COG0486@2|Bacteria,46SIQ@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD1_k127_5329304_3	497964.CfE428DRAFT_4708	6.079e-114	377.0	COG0167@1|root,COG0167@2|Bacteria,46S5W@74201|Verrucomicrobia	74201|Verrucomicrobia	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5331996_6	945713.IALB_2142	1.172e-165	533.0	COG0031@1|root,COG3620@1|root,COG0031@2|Bacteria,COG3620@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	cbs	GO:0003674,GO:0005488,GO:0005575,GO:0005576,GO:0005618,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0008144,GO:0016020,GO:0019842,GO:0030170,GO:0030312,GO:0036094,GO:0043167,GO:0043168,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0070279,GO:0071944,GO:0097159,GO:1901363	2.5.1.47,4.2.1.22	ko:K01697,ko:K01738	ko00260,ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021,M00035,M00338	R00891,R00897,R01290,R03601,R04859,R04942	RC00020,RC00056,RC00069,RC00256,RC00489,RC01246,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	CBS,PALP
HKD1_k127_5331996_46	1403313.AXBR01000006_gene102	4.981e-26	113.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,4HIGJ@91061|Bacilli,1ZG71@1386|Bacillus	91061|Bacilli	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	dfrA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD1_k127_5331996_36	234267.Acid_0972	2.638e-37	149.0	COG1708@1|root,COG1708@2|Bacteria,3Y7NX@57723|Acidobacteria	57723|Acidobacteria	S	nucleotidyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5331996_29	2325.TKV_c02940	5.596e-54	198.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia,42G50@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM LemA family protein	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_5331996_48	390874.Tpet_1787	1.556e-24	114.0	COG1512@1|root,COG1512@2|Bacteria,2GDT8@200918|Thermotogae	200918|Thermotogae	S	Methanol dehydrogenase	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_5331996_19	1120977.JHUX01000003_gene2072	7.628e-106	350.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,1RPYV@1236|Gammaproteobacteria,3NKAC@468|Moraxellaceae	1236|Gammaproteobacteria	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	GO:0000287,GO:0003674,GO:0003824,GO:0004799,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006220,GO:0006221,GO:0006231,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009129,GO:0009130,GO:0009157,GO:0009162,GO:0009165,GO:0009176,GO:0009177,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009314,GO:0009394,GO:0009628,GO:0009987,GO:0016740,GO:0016741,GO:0018130,GO:0019438,GO:0019637,GO:0019692,GO:0032259,GO:0034641,GO:0034654,GO:0042083,GO:0043167,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046073,GO:0046385,GO:0046483,GO:0046872,GO:0050896,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iAF1260.b2827,iAPECO1_1312.APECO1_3678,iBWG_1329.BWG_2562,iE2348C_1286.E2348C_3096,iEC042_1314.EC042_3024,iEC55989_1330.EC55989_3103,iECABU_c1320.ECABU_c31240,iECDH10B_1368.ECDH10B_2997,iECDH1ME8569_1439.ECDH1ME8569_2734,iECED1_1282.ECED1_3283,iECH74115_1262.ECH74115_4093,iECIAI1_1343.ECIAI1_2935,iECIAI39_1322.ECIAI39_3246,iECNA114_1301.ECNA114_2885,iECO103_1326.ECO103_3386,iECO111_1330.ECO111_3555,iECO26_1355.ECO26_3899,iECOK1_1307.ECOK1_3231,iECP_1309.ECP_2840,iECS88_1305.ECS88_3122,iECSE_1348.ECSE_3084,iECSF_1327.ECSF_2642,iECSP_1301.ECSP_3779,iECUMN_1333.ECUMN_3154,iECW_1372.ECW_m3069,iECs_1301.ECs3684,iEKO11_1354.EKO11_0914,iETEC_1333.ETEC_3014,iEcDH1_1363.EcDH1_0864,iEcE24377_1341.EcE24377A_3147,iEcSMS35_1347.EcSMS35_2974,iG2583_1286.G2583_3481,iJO1366.b2827,iJR904.b2827,iLF82_1304.LF82_2267,iNRG857_1313.NRG857_13965,iSSON_1240.SSON_2984,iUMN146_1321.UM146_02290,iUMNK88_1353.UMNK88_3511,iUTI89_1310.UTI89_C3229,iWFL_1372.ECW_m3069,iY75_1357.Y75_RS14705,iYL1228.KPN_03236,iZ_1308.Z4144,ic_1306.c3422	Thymidylat_synt
HKD1_k127_5331996_13	861299.J421_4340	7.679e-140	457.0	COG0520@1|root,COG0520@2|Bacteria,1ZSV8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_5331996_33	886293.Sinac_4160	1.031e-41	160.0	COG0071@1|root,COG0071@2|Bacteria,2J11X@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_5331996_37	234267.Acid_0752	6.271e-37	143.0	COG0517@1|root,COG0517@2|Bacteria,3Y8IB@57723|Acidobacteria	57723|Acidobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_5331996_14	1267535.KB906767_gene4789	1.114e-132	430.0	COG1064@1|root,COG1064@2|Bacteria,3Y34K@57723|Acidobacteria,2JIU5@204432|Acidobacteriia	204432|Acidobacteriia	S	Zinc-binding alcohol dehydrogenase family protein	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HKD1_k127_5331996_4	452637.Oter_4049	2.081e-169	549.0	COG0661@1|root,COG0661@2|Bacteria,46UJV@74201|Verrucomicrobia,3K7NS@414999|Opitutae	414999|Opitutae	S	ABC1 family	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD1_k127_5331996_9	269799.Gmet_2971	3.136e-154	503.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,42NG3@68525|delta/epsilon subdivisions,2WJ95@28221|Deltaproteobacteria,43S64@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Domain of unknown function (DUF4070)	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_5331996_27	626887.J057_17720	4.718e-63	225.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,1RNJ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD1_k127_5331996_26	626887.J057_17725	1.262e-70	248.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,1RNJ7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	-	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku,Rho_N
HKD1_k127_5331996_54	1123242.JH636434_gene5557	4.503e-14	85.0	COG4968@1|root,COG4968@2|Bacteria,2IZ2M@203682|Planctomycetes	203682|Planctomycetes	NU	Prokaryotic N-terminal methylation motif	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl,SBP_bac_10
HKD1_k127_5331996_7	941824.TCEL_01148	7.879e-161	518.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,36DMV@31979|Clostridiaceae	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD1_k127_5331996_38	408672.NBCG_03194	2.938e-36	141.0	COG1393@1|root,COG1393@2|Bacteria,2HZGX@201174|Actinobacteria,4DSRW@85009|Propionibacteriales	201174|Actinobacteria	P	ArsC family	-	-	-	-	-	-	-	-	-	-	-	-	ArsC
HKD1_k127_5331996_8	525904.Tter_0805	9.473e-157	505.0	COG0334@1|root,COG0334@2|Bacteria,2NNRJ@2323|unclassified Bacteria	2|Bacteria	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_5331996_55	234267.Acid_1280	1.709e-11	74.0	COG0810@1|root,COG0810@2|Bacteria,3Y31T@57723|Acidobacteria	57723|Acidobacteria	M	TIGRFAM TonB family	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD1_k127_5331996_11	1340493.JNIF01000004_gene472	6.493e-142	457.0	COG1793@1|root,COG1793@2|Bacteria,3Y45N@57723|Acidobacteria	57723|Acidobacteria	L	PFAM ATP dependent DNA ligase	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD1_k127_5331996_10	234267.Acid_5076	6.041e-145	470.0	COG3285@1|root,COG3285@2|Bacteria,3Y74I@57723|Acidobacteria	57723|Acidobacteria	L	dna ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HKD1_k127_5331996_43	357808.RoseRS_1901	5.01e-31	124.0	2BHS9@1|root,32BVT@2|Bacteria,2GBBD@200795|Chloroflexi,377P4@32061|Chloroflexia	32061|Chloroflexia	S	Domain of unknown function (DUF4160)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4160
HKD1_k127_5331996_41	926550.CLDAP_08610	3.648e-33	130.0	2A50H@1|root,30TNP@2|Bacteria,2G96I@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF2442)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2442
HKD1_k127_5331996_0	748280.NH8B_2766	0.0	1701.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2VI8X@28216|Betaproteobacteria	28216|Betaproteobacteria	L	DEAD DEAH box helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD1_k127_5331996_53	690585.JNNU01000032_gene1030	4.102e-15	78.0	2EPV2@1|root,33HFI@2|Bacteria,1P857@1224|Proteobacteria,2VGGE@28211|Alphaproteobacteria,4BNJH@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5331996_44	234267.Acid_0752	4.331e-28	119.0	COG0517@1|root,COG0517@2|Bacteria,3Y8IB@57723|Acidobacteria	57723|Acidobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_5331996_49	378806.STAUR_7788	3.229e-24	104.0	COG3668@1|root,32ZH9@2|Bacteria,1N7YH@1224|Proteobacteria,43843@68525|delta/epsilon subdivisions,2X9WS@28221|Deltaproteobacteria,2YVMZ@29|Myxococcales	28221|Deltaproteobacteria	S	COG3668 Plasmid stabilization system protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5331996_39	211165.AJLN01000014_gene4580	8.143e-36	143.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD1_k127_5331996_3	234267.Acid_7730	1.039e-176	563.0	COG1415@1|root,COG1415@2|Bacteria,3Y6D2@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF763)	-	-	-	ko:K09003	-	-	-	-	ko00000	-	-	-	DUF763
HKD1_k127_5331996_42	267377.MMP0730	5.534e-32	130.0	arCOG06631@1|root,arCOG06631@2157|Archaea,2Y0V4@28890|Euryarchaeota,23RNY@183939|Methanococci	183939|Methanococci	S	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_5331996_12	1396141.BATP01000003_gene5228	1.04e-141	460.0	COG0451@1|root,COG0451@2|Bacteria,46XPQ@74201|Verrucomicrobia,2IWC3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5331996_50	1122138.AQUZ01000019_gene8171	1.628e-22	113.0	COG1520@1|root,COG4733@1|root,COG1520@2|Bacteria,COG4733@2|Bacteria	2|Bacteria	S	cellulase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,F5_F8_type_C,PQQ_2,SLH
HKD1_k127_5331996_15	1163409.UUA_03818	5.301e-131	442.0	COG3055@1|root,COG3055@2|Bacteria,1NHAC@1224|Proteobacteria,1RYBY@1236|Gammaproteobacteria,1XAGU@135614|Xanthomonadales	135614|Xanthomonadales	S	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5331996_18	452637.Oter_1629	2.319e-114	378.0	COG0266@1|root,COG0266@2|Bacteria	2|Bacteria	L	class I DNA-(apurinic or apyrimidinic site) endonuclease activity	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD1_k127_5331996_45	1479239.JQMU01000001_gene2452	5.556e-28	125.0	COG2885@1|root,COG2885@2|Bacteria,1R5IS@1224|Proteobacteria,2U2V8@28211|Alphaproteobacteria,2K1H8@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD1_k127_5331996_59	649349.Lbys_2090	0.0006291	42.0	COG2234@1|root,COG2234@2|Bacteria,4NE66@976|Bacteroidetes,47M14@768503|Cytophagia	976|Bacteroidetes	G	Peptidase, M28	PGCP	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_5331996_51	1122179.KB890418_gene3754	2.119e-21	99.0	COG0454@1|root,COG0454@2|Bacteria,4PPP5@976|Bacteroidetes	976|Bacteroidetes	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_5331996_21	63737.Npun_F2216	3.632e-92	307.0	COG2258@1|root,COG2258@2|Bacteria,1G4BR@1117|Cyanobacteria,1HQ1K@1161|Nostocales	1117|Cyanobacteria	S	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	3-alpha,MOSC
HKD1_k127_5331996_2	118161.KB235922_gene2360	2.221e-244	769.0	COG1680@1|root,COG1680@2|Bacteria,1G5M7@1117|Cyanobacteria	1117|Cyanobacteria	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HKD1_k127_5331996_52	290315.Clim_1323	1.239e-18	93.0	2ECCI@1|root,342SB@2|Bacteria,1FFBH@1090|Chlorobi	1090|Chlorobi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5331996_28	1123508.JH636440_gene2901	1.018e-59	209.0	COG0346@1|root,COG0346@2|Bacteria,2J081@203682|Planctomycetes	203682|Planctomycetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5331996_35	761193.Runsl_5349	5.842e-38	145.0	COG0346@1|root,COG0346@2|Bacteria,4NRR7@976|Bacteroidetes,47QT0@768503|Cytophagia	976|Bacteroidetes	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_5331996_57	471852.Tcur_1848	4.169e-07	60.0	COG4675@1|root,COG4675@2|Bacteria,2I6J3@201174|Actinobacteria	201174|Actinobacteria	S	Collagen triple helix repeat (20 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
HKD1_k127_5331996_1	234267.Acid_7252	0.0	1436.0	COG4447@1|root,COG4447@2|Bacteria,3Y69Z@57723|Acidobacteria	57723|Acidobacteria	S	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_5331996_31	1349767.GJA_3765	1.04e-46	177.0	COG0671@1|root,COG0671@2|Bacteria,1QV0A@1224|Proteobacteria,2WGP2@28216|Betaproteobacteria,474QC@75682|Oxalobacteraceae	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_5331996_17	234267.Acid_1863	1.057e-124	409.0	COG4956@1|root,COG4956@2|Bacteria,3Y2RT@57723|Acidobacteria	57723|Acidobacteria	S	Large family of predicted nucleotide-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
HKD1_k127_5331996_32	1297581.H919_08921	2.128e-45	173.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,4HH2N@91061|Bacilli,21VAJ@150247|Anoxybacillus	91061|Bacilli	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	GO:0003674,GO:0003824,GO:0016740,GO:0016772,GO:0016779,GO:0050518,GO:0070567	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD
HKD1_k127_5331996_30	518766.Rmar_1099	1.269e-49	181.0	COG0245@1|root,COG0245@2|Bacteria,4NP0N@976|Bacteroidetes,1FJAC@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	4.6.1.12	ko:K01770	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	YgbB
HKD1_k127_5331996_16	886293.Sinac_1427	9.994e-125	413.0	COG0213@1|root,COG0213@2|Bacteria,2IY57@203682|Planctomycetes	203682|Planctomycetes	F	PFAM Glycosyl transferase, family	-	-	2.4.2.2	ko:K00756	ko00240,ko01100,map00240,map01100	-	R01570,R01876,R02296,R02484	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD1_k127_5331996_23	264462.Bd0445	8.494e-89	305.0	COG1744@1|root,COG1744@2|Bacteria,1NGHH@1224|Proteobacteria,42RBQ@68525|delta/epsilon subdivisions,2MTH8@213481|Bdellovibrionales,2WN1W@28221|Deltaproteobacteria	213481|Bdellovibrionales	S	PFAM Basic membrane lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD1_k127_5331996_34	338963.Pcar_1793	1.972e-41	156.0	2B1XW@1|root,31UE7@2|Bacteria,1NXJ5@1224|Proteobacteria	1224|Proteobacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_5331996_5	869210.Marky_0993	8.857e-169	544.0	COG3845@1|root,COG3845@2|Bacteria,1WIKU@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_5331996_22	748449.Halha_0739	5.952e-90	308.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,3WAFN@53433|Halanaerobiales	186801|Clostridia	U	PFAM Branched-chain amino acid transport system permease component	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_5331996_24	515635.Dtur_1155	2.374e-83	287.0	COG1079@1|root,COG1079@2|Bacteria	2|Bacteria	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_5331996_20	1430331.EP10_18360	2.358e-97	325.0	COG0005@1|root,COG0005@2|Bacteria,1TQ37@1239|Firmicutes,4HABP@91061|Bacilli,1WE42@129337|Geobacillus	91061|Bacilli	F	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate	punA	-	2.4.2.1,2.4.2.28	ko:K00772,ko:K03783	ko00230,ko00240,ko00270,ko00760,ko01100,ko01110,map00230,map00240,map00270,map00760,map01100,map01110	M00034	R01402,R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122,RC02819	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_5331996_25	518766.Rmar_0382	1.627e-71	248.0	COG0572@1|root,COG0572@2|Bacteria,4NEEC@976|Bacteroidetes,1FIYA@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	F	Phosphoribulokinase / Uridine kinase family	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HKD1_k127_5331996_40	234267.Acid_5234	2.255e-33	132.0	COG0295@1|root,COG0295@2|Bacteria,3Y5GE@57723|Acidobacteria	57723|Acidobacteria	F	Cytidine and deoxycytidylate deaminase zinc-binding region	-	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD1_k127_5347374_3	762903.Pedsa_3738	4.307e-199	632.0	COG3250@1|root,COG3250@2|Bacteria,4NHU5@976|Bacteroidetes,1IPCB@117747|Sphingobacteriia	976|Bacteroidetes	G	Glycosyl hydrolases family 2, sugar binding domain	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_5347374_5	861299.J421_5619	2.415e-197	627.0	COG5434@1|root,COG5434@2|Bacteria	2|Bacteria	M	polygalacturonase activity	-	-	3.2.1.15	ko:K01184	ko00040,ko01100,map00040,map01100	M00081	R01982,R02360	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_28,Pectate_lyase_3
HKD1_k127_5347374_4	1121904.ARBP01000031_gene559	1.464e-197	628.0	COG2755@1|root,COG2755@2|Bacteria,4NK31@976|Bacteroidetes	976|Bacteroidetes	E	Sialate O-acetylesterase	-	-	3.1.1.53	ko:K05970	-	-	-	-	ko00000,ko01000	-	-	-	SASA
HKD1_k127_5347374_2	1267535.KB906767_gene1348	3.331e-201	644.0	COG3534@1|root,COG3534@2|Bacteria,3Y48A@57723|Acidobacteria,2JKQ1@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-arabinofuranosidase C-terminus	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HKD1_k127_5347374_0	234267.Acid_1227	0.0	1091.0	COG1629@1|root,COG4771@2|Bacteria	234267.Acid_1227|-	P	TonB-dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5347374_1	682795.AciX8_2301	6.716e-292	924.0	COG3250@1|root,COG3250@2|Bacteria,3Y3MQ@57723|Acidobacteria,2JKAJ@204432|Acidobacteriia	204432|Acidobacteriia	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
HKD1_k127_5347374_6	234267.Acid_4418	6.093e-50	186.0	COG1629@1|root,COG4771@2|Bacteria,3Y3KA@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_5351193_6	1382359.JIAL01000001_gene1975	5.03e-104	356.0	COG0771@1|root,COG0771@2|Bacteria,3Y2JK@57723|Acidobacteria,2JHQF@204432|Acidobacteriia	204432|Acidobacteriia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_5351193_4	240015.ACP_1089	8.739e-116	384.0	COG0472@1|root,COG0472@2|Bacteria,3Y2ZH@57723|Acidobacteria,2JIGX@204432|Acidobacteriia	204432|Acidobacteriia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD1_k127_5351193_10	204669.Acid345_3633	5.724e-88	309.0	COG0770@1|root,COG0770@2|Bacteria,3Y3I2@57723|Acidobacteria,2JHW4@204432|Acidobacteriia	204432|Acidobacteriia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_5351193_1	204669.Acid345_3635	2.799e-153	508.0	COG0768@1|root,COG0768@2|Bacteria,3Y2XX@57723|Acidobacteria,2JHPS@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein, dimerisation domain	-	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD1_k127_5351193_9	1121468.AUBR01000006_gene356	1.418e-89	304.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,42EWY@68295|Thermoanaerobacterales	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_5351193_14	1382359.JIAL01000001_gene1949	3.603e-46	170.0	COG2001@1|root,COG2001@2|Bacteria,3Y4NF@57723|Acidobacteria,2JJA0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_5351193_22	575540.Isop_1629	0.0002622	49.0	COG4576@1|root,COG4576@2|Bacteria,2J03B@203682|Planctomycetes	203682|Planctomycetes	CQ	PFAM Ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HKD1_k127_5351193_18	234267.Acid_0323	4.757e-21	95.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HKD1_k127_5351193_17	234267.Acid_0322	7.249e-30	121.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	-	-	-	ko:K04028,ko:K08697	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HKD1_k127_5351193_16	1449126.JQKL01000004_gene588	1.391e-33	131.0	COG4577@1|root,COG4577@2|Bacteria,1VA0E@1239|Firmicutes,24N43@186801|Clostridia,269DX@186813|unclassified Clostridiales	186801|Clostridia	CQ	BMC domain	-	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_5351193_11	697281.Mahau_1416	2.626e-59	214.0	COG0235@1|root,COG0235@2|Bacteria,1TS5G@1239|Firmicutes,248NY@186801|Clostridia,42FQD@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM Class II aldolase adducin	-	-	4.1.2.17	ko:K01628	ko00051,ko01120,map00051,map01120	-	R02262	RC00603,RC00604	ko00000,ko00001,ko01000	-	-	-	Aldolase_II
HKD1_k127_5351193_12	443254.Marpi_0360	2.994e-52	194.0	COG2344@1|root,COG2344@2|Bacteria,2GCZC@200918|Thermotogae	200918|Thermotogae	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HKD1_k127_5351193_13	234267.Acid_0956	3.213e-46	175.0	COG0632@1|root,COG0632@2|Bacteria,3Y4KI@57723|Acidobacteria	57723|Acidobacteria	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD1_k127_5351193_2	395493.BegalDRAFT_1943	3.735e-134	436.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,1RNWY@1236|Gammaproteobacteria,45ZRZ@72273|Thiotrichales	72273|Thiotrichales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD1_k127_5351193_19	1487921.DP68_10985	1.917e-20	102.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,24A2Q@186801|Clostridia,36ESU@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_5351193_5	867903.ThesuDRAFT_01678	6.113e-106	355.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,3WCFH@538999|Clostridiales incertae sedis	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD1_k127_5351193_20	186497.PF0267	5.524e-15	83.0	COG0456@1|root,arCOG00833@2157|Archaea,2Y0G0@28890|Euryarchaeota,2432R@183968|Thermococci	183968|Thermococci	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_5351193_7	204669.Acid345_0708	1.061e-92	307.0	COG1100@1|root,COG1100@2|Bacteria,3Y7CQ@57723|Acidobacteria	57723|Acidobacteria	S	ADP-ribosylation factor family	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Arf
HKD1_k127_5351193_15	290397.Adeh_3634	2.592e-42	162.0	COG2018@1|root,COG2018@2|Bacteria,1RDN5@1224|Proteobacteria,42S13@68525|delta/epsilon subdivisions,2WNKB@28221|Deltaproteobacteria,2YV9Q@29|Myxococcales	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	mglB	-	-	-	-	-	-	-	-	-	-	-	Robl_LC7
HKD1_k127_5351193_21	1267533.KB906735_gene4727	7.256e-11	72.0	COG0457@1|root,COG0457@2|Bacteria,3Y85Z@57723|Acidobacteria,2JN52@204432|Acidobacteriia	204432|Acidobacteriia	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5351193_8	1382359.JIAL01000001_gene1385	5.987e-92	316.0	COG0391@1|root,COG0391@2|Bacteria,3Y3ZE@57723|Acidobacteria,2JITK@204432|Acidobacteriia	204432|Acidobacteriia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD1_k127_5351193_3	335541.Swol_0067	1.714e-132	437.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,42JPG@68298|Syntrophomonadaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
HKD1_k127_5351193_0	204669.Acid345_0997	1.49e-273	854.0	COG0449@1|root,COG0449@2|Bacteria,3Y2NE@57723|Acidobacteria,2JI69@204432|Acidobacteriia	204432|Acidobacteriia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_5385321_0	497964.CfE428DRAFT_5970	2.29e-215	678.0	COG1217@1|root,COG1217@2|Bacteria,46SHA@74201|Verrucomicrobia	74201|Verrucomicrobia	T	elongation factor Tu domain 2 protein	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_5385321_2	1463920.JOGB01000009_gene702	7.578e-86	290.0	COG0684@1|root,COG0684@2|Bacteria,2I9PH@201174|Actinobacteria	201174|Actinobacteria	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD1_k127_5385321_8	1031711.RSPO_c00082	1.078e-49	181.0	COG2940@1|root,COG2940@2|Bacteria,1MWFB@1224|Proteobacteria,2VR5U@28216|Betaproteobacteria,1K2B1@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Nuclear protein SET	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD1_k127_5385321_5	1210884.HG799467_gene13302	1.239e-59	218.0	COG0583@1|root,COG0583@2|Bacteria,2IXKS@203682|Planctomycetes	203682|Planctomycetes	K	Hydrogen peroxide-inducible genes activator	-	-	-	ko:K04761,ko:K11921	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_5385321_4	240016.ABIZ01000001_gene2554	4.975e-70	258.0	COG1075@1|root,COG1075@2|Bacteria	2|Bacteria	KLT	acetyltransferases and hydrolases with the alpha beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6,DUF676,Hydrolase_4,PGAP1
HKD1_k127_5385321_1	1202532.FF52_04800	1.191e-185	608.0	COG5164@1|root,COG5164@2|Bacteria,4NFN0@976|Bacteroidetes,1IMWB@117743|Flavobacteriia,2NVM5@237|Flavobacterium	976|Bacteroidetes	K	regulation of DNA-templated transcription, elongation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5385321_7	335543.Sfum_0591	9.402e-50	183.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,42S9D@68525|delta/epsilon subdivisions,2WN8Y@28221|Deltaproteobacteria,2MQJ7@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_5385321_9	767434.Fraau_2325	1.433e-49	183.0	COG0406@1|root,COG0406@2|Bacteria,1N8C6@1224|Proteobacteria	1224|Proteobacteria	G	alpha-ribazole phosphatase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5385321_13	981384.AEYW01000028_gene4250	1.432e-10	71.0	2C4HM@1|root,2ZFRV@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5385321_6	1267534.KB906755_gene4464	9.079e-59	214.0	2C2X7@1|root,31WBU@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD1_k127_5385321_11	264198.Reut_A1129	2.613e-28	121.0	2E06S@1|root,32VUR@2|Bacteria,1N3ZV@1224|Proteobacteria,2W4J8@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5385321_3	398525.KB900701_gene5677	9.663e-73	247.0	COG0599@1|root,COG0599@2|Bacteria,1N0Z6@1224|Proteobacteria,2VGPU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_5410285_0	497964.CfE428DRAFT_0348	2.27e-322	1008.0	COG0612@1|root,COG0612@2|Bacteria,46S9I@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM peptidase M16 domain protein	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_5410285_2	497964.CfE428DRAFT_0347	1.532e-41	158.0	2E5IJ@1|root,3309Y@2|Bacteria,46SYV@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5410285_1	497964.CfE428DRAFT_2285	2.374e-50	197.0	2C7EB@1|root,347YC@2|Bacteria,46W4Z@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5456175_15	246197.MXAN_6606	2.563e-57	214.0	28M67@1|root,31CRD@2|Bacteria,1QASJ@1224|Proteobacteria,438U9@68525|delta/epsilon subdivisions,2X40D@28221|Deltaproteobacteria,2YXSR@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5456175_1	264732.Moth_0265	1.358e-182	584.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,42FP5@68295|Thermoanaerobacterales	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD1_k127_5456175_20	364733.XP_007803463.1	4.876e-05	49.0	2E6UA@1|root,2SDGY@2759|Eukaryota,3A60Q@33154|Opisthokonta,3P5QW@4751|Fungi,3QXEI@4890|Ascomycota,20IHU@147545|Eurotiomycetes,3MTII@451870|Chaetothyriomycetidae	4751|Fungi	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_15
HKD1_k127_5456175_16	926560.KE387023_gene1429	2.761e-53	192.0	COG0454@1|root,COG0454@2|Bacteria,1WMQ1@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_7
HKD1_k127_5456175_17	1379698.RBG1_1C00001G0743	4.179e-36	143.0	COG2318@1|root,COG2318@2|Bacteria,2NRHG@2323|unclassified Bacteria	2|Bacteria	S	DinB superfamily	dinB	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	DinB
HKD1_k127_5456175_0	889378.Spiaf_0670	1.506e-195	619.0	COG0148@1|root,COG0148@2|Bacteria,2J59Y@203691|Spirochaetes	203691|Spirochaetes	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_5456175_4	1340493.JNIF01000003_gene1347	7.697e-137	458.0	COG1574@1|root,COG1574@2|Bacteria,3Y2UF@57723|Acidobacteria	57723|Acidobacteria	S	PFAM amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_5456175_10	497965.Cyan7822_5512	1.927e-94	317.0	COG1125@1|root,COG1125@2|Bacteria,1G21Q@1117|Cyanobacteria,3KHZZ@43988|Cyanothece	1117|Cyanobacteria	P	PFAM ABC transporter related	-	-	-	ko:K05847	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	ABC_tran,CBS
HKD1_k127_5456175_3	99598.Cal7507_5457	2.374e-155	507.0	COG1174@1|root,COG1732@1|root,COG1174@2|Bacteria,COG1732@2|Bacteria,1G1ZS@1117|Cyanobacteria,1HJFJ@1161|Nostocales	1117|Cyanobacteria	M	Substrate binding domain of ABC-type glycine betaine transport system	-	-	-	ko:K05845,ko:K05846	ko02010,map02010	M00209	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.12	-	-	BPD_transp_1,OpuAC
HKD1_k127_5456175_11	1340493.JNIF01000003_gene4032	6.379e-82	289.0	COG0577@1|root,COG0577@2|Bacteria,3Y2MV@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_5456175_9	234267.Acid_5981	1.469e-102	348.0	COG0577@1|root,COG0577@2|Bacteria,3Y3XI@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_5456175_18	56780.SYN_00526	7.478e-35	143.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,42RQP@68525|delta/epsilon subdivisions,2WNQ7@28221|Deltaproteobacteria,2MRTQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	T	Calcineurin-like phosphoesterase	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_5456175_5	926566.Terro_2493	4.425e-125	430.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y44T@57723|Acidobacteria,2JP2J@204432|Acidobacteriia	204432|Acidobacteriia	KLT	PFAM Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11
HKD1_k127_5456175_6	926690.KE386573_gene1707	3.408e-124	410.0	COG0477@1|root,arCOG00130@2157|Archaea,2XT8X@28890|Euryarchaeota,23TJU@183963|Halobacteria	183963|Halobacteria	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_5456175_14	393595.ABO_2666	7.887e-59	226.0	COG2199@1|root,COG2202@1|root,COG2203@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG3706@2|Bacteria,1R7HC@1224|Proteobacteria,1T2N9@1236|Gammaproteobacteria,1XJNX@135619|Oceanospirillales	135619|Oceanospirillales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,PAS_3
HKD1_k127_5456175_2	1267533.KB906733_gene3096	5.832e-156	510.0	COG1215@1|root,COG1215@2|Bacteria,3Y31I@57723|Acidobacteria,2JIKW@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_5456175_19	1267534.KB906754_gene3160	1.173e-24	107.0	2EE2W@1|root,337XH@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5456175_8	443598.AUFA01000003_gene2112	3.621e-110	365.0	COG4307@1|root,COG4307@2|Bacteria,1MXES@1224|Proteobacteria,2U06R@28211|Alphaproteobacteria,3JRXQ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Putative zinc-binding metallo-peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_Mx
HKD1_k127_5456175_7	330214.NIDE0474	1.029e-115	384.0	COG1181@1|root,COG1181@2|Bacteria	2|Bacteria	F	Belongs to the D-alanine--D-alanine ligase family	ddlB1	-	6.3.2.4,6.3.5.5	ko:K01921,ko:K01955	ko00240,ko00250,ko00473,ko00550,ko01100,ko01502,map00240,map00250,map00473,map00550,map01100,map01502	M00051	R00256,R00575,R01150,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC00064,RC00141,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000,ko01011	-	-	-	Dala_Dala_lig_C
HKD1_k127_5456175_13	404589.Anae109_0783	1.246e-61	225.0	COG0122@1|root,COG0122@2|Bacteria,1P0FP@1224|Proteobacteria	1224|Proteobacteria	L	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_5493256_14	1121898.Q766_12995	7.001e-12	75.0	COG0741@1|root,COG0741@2|Bacteria,4NH4W@976|Bacteroidetes,1HXX8@117743|Flavobacteriia,2NU2Q@237|Flavobacterium	976|Bacteroidetes	M	Murein transglycosylase	mltD_2	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD1_k127_5493256_10	1183438.GKIL_3942	3.53e-57	206.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_5493256_9	1267535.KB906767_gene1129	5.596e-79	290.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_5493256_7	483219.LILAB_18670	8.597e-103	348.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	2.4.1.250	ko:K15521	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_trans_1_2,Glyco_transf_4,Glyco_transf_9,Glycos_transf_1,Glycos_transf_2,TPR_1,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_5493256_11	1267535.KB906767_gene341	1.191e-52	192.0	28JRZ@1|root,2Z9HI@2|Bacteria,3Y7HD@57723|Acidobacteria	57723|Acidobacteria	S	Domain of unknown function (DUF4126)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4126
HKD1_k127_5493256_1	1341155.FSS13T_26600	4.157e-309	975.0	COG3537@1|root,COG3537@2|Bacteria,4NDYB@976|Bacteroidetes,1HWR3@117743|Flavobacteriia,2NSK3@237|Flavobacterium	976|Bacteroidetes	G	hydrolase family 92	-	-	-	-	-	-	-	-	-	-	-	-	CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc,Glyco_hydro_92
HKD1_k127_5493256_4	1501230.ET33_13205	1.412e-178	599.0	COG1874@1|root,COG1874@2|Bacteria,1UIWU@1239|Firmicutes,4HCA7@91061|Bacilli,26UV7@186822|Paenibacillaceae	91061|Bacilli	G	Glycoside hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42
HKD1_k127_5493256_3	1267534.KB906760_gene1549	6.514e-216	700.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_5493256_5	641524.ADICYQ_5472	9.674e-163	530.0	COG3119@1|root,COG3119@2|Bacteria,4NHH7@976|Bacteroidetes,47JYR@768503|Cytophagia	976|Bacteroidetes	P	PFAM sulfatase	mdsA	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HKD1_k127_5493256_13	234267.Acid_0924	7.038e-29	121.0	COG3162@1|root,COG3162@2|Bacteria	2|Bacteria	S	Protein of unknown function, DUF485	-	-	-	-	-	-	-	-	-	-	-	-	DUF485
HKD1_k127_5493256_2	234267.Acid_0925	3.283e-243	761.0	COG4147@1|root,COG4147@2|Bacteria	2|Bacteria	S	glycolate transport	ywcA	-	-	ko:K14393	-	-	-	-	ko00000,ko02000	2.A.21.7	-	iAF987.Gmet_0739	SSF
HKD1_k127_5493256_8	234267.Acid_5254	1.665e-98	334.0	COG3608@1|root,COG3608@2|Bacteria,3Y8T6@57723|Acidobacteria	2|Bacteria	S	Succinylglutamate desuccinylase / Aspartoacylase family	-	-	-	ko:K06987	-	-	-	-	ko00000	-	-	-	AstE_AspA
HKD1_k127_5493256_6	204669.Acid345_1052	3.861e-155	517.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_5493256_0	234267.Acid_0469	0.0	1178.0	COG1506@1|root,COG1506@2|Bacteria,3Y3DT@57723|Acidobacteria	57723|Acidobacteria	E	peptidase S9B dipeptidylpeptidase IV domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,Peptidase_S9
HKD1_k127_5493256_12	1248916.ANFY01000005_gene2838	2.183e-47	178.0	2BS4J@1|root,32M5G@2|Bacteria,1NU6I@1224|Proteobacteria,2UQIE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5576100_0	1237149.C900_05550	4.221e-288	903.0	COG1506@1|root,COG1506@2|Bacteria,4NETS@976|Bacteroidetes,47KF8@768503|Cytophagia	976|Bacteroidetes	EU	Dipeptidyl peptidase IV (DPP IV) N-terminal region	-	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
HKD1_k127_5576100_1	1123269.NX02_11500	2.112e-169	548.0	COG4805@1|root,COG4805@2|Bacteria,1NRZP@1224|Proteobacteria,2UNXX@28211|Alphaproteobacteria,2K9QH@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD1_k127_5576100_6	211165.AJLN01000107_gene5635	5.474e-25	110.0	COG2114@1|root,COG2114@2|Bacteria,1GA0B@1117|Cyanobacteria,1JISD@1189|Stigonemataceae	1117|Cyanobacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_cyc
HKD1_k127_5576100_4	373994.Riv7116_4166	1.036e-54	196.0	COG1100@1|root,COG1100@2|Bacteria,1G5QQ@1117|Cyanobacteria,1HNBR@1161|Nostocales	1117|Cyanobacteria	S	TIGRFAM Small GTP-binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	Ras
HKD1_k127_5576100_2	1173024.KI912149_gene5318	1.66e-144	477.0	COG2885@1|root,COG2885@2|Bacteria,1G2YF@1117|Cyanobacteria,1JGWQ@1189|Stigonemataceae	1117|Cyanobacteria	M	OmpA family	-	-	-	ko:K02557,ko:K03286	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1,1.B.6	-	-	OmpA
HKD1_k127_5576100_5	99598.Cal7507_2709	2.968e-34	139.0	COG1322@1|root,COG1322@2|Bacteria,1G77N@1117|Cyanobacteria,1HSB1@1161|Nostocales	1117|Cyanobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5576100_3	195253.Syn6312_2848	1.182e-57	219.0	COG0671@1|root,COG1572@1|root,COG3209@1|root,COG0671@2|Bacteria,COG1572@2|Bacteria,COG3209@2|Bacteria,1GHH3@1117|Cyanobacteria,1H44C@1129|Synechococcus	1117|Cyanobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,PAP2
HKD1_k127_5578032_25	234267.Acid_3611	7.565e-72	254.0	COG1734@1|root,COG2208@1|root,COG1734@2|Bacteria,COG2208@2|Bacteria,3Y4RV@57723|Acidobacteria	57723|Acidobacteria	KT	Sigma factor PP2C-like phosphatases	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
HKD1_k127_5578032_54	439235.Dalk_4189	1.448e-05	56.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_5578032_45	1210884.HG799462_gene8487	9.852e-19	92.0	COG0517@1|root,COG0517@2|Bacteria,2J0FD@203682|Planctomycetes	203682|Planctomycetes	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_5578032_2	945713.IALB_1501	1.078e-254	799.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria	2|Bacteria	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	korA	GO:0003674,GO:0003824,GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0016020,GO:0016491,GO:0030312,GO:0044464,GO:0050896,GO:0055114,GO:0071944	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD1_k127_5578032_9	314230.DSM3645_04355	3.889e-140	454.0	COG1013@1|root,COG1013@2|Bacteria,2IY6Z@203682|Planctomycetes	203682|Planctomycetes	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD1_k127_5578032_41	1210884.HG799462_gene8483	1.146e-22	104.0	COG0517@1|root,COG0517@2|Bacteria,2J0MQ@203682|Planctomycetes	203682|Planctomycetes	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_5578032_18	1379698.RBG1_1C00001G0290	2.454e-83	306.0	COG0308@1|root,COG0308@2|Bacteria,2NPGQ@2323|unclassified Bacteria	2|Bacteria	E	aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1,PD40,Peptidase_M1
HKD1_k127_5578032_28	1267534.KB906754_gene2659	2.303e-60	211.0	COG2197@1|root,COG2197@2|Bacteria,3Y60I@57723|Acidobacteria	57723|Acidobacteria	KT	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE
HKD1_k127_5578032_29	861299.J421_4133	1.358e-56	202.0	2CB8S@1|root,30PE6@2|Bacteria,1ZV1Q@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF4199)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4199
HKD1_k127_5578032_16	1095769.CAHF01000006_gene1901	2.275e-105	348.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2VJM3@28216|Betaproteobacteria,474EJ@75682|Oxalobacteraceae	28216|Betaproteobacteria	Q	ubiE/COQ5 methyltransferase family	ubiE_1	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_5578032_4	234267.Acid_5342	6.39e-194	614.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053,ko:K13735	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05100,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220,map05100	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	NHL,SGL
HKD1_k127_5578032_19	1173023.KE650771_gene2850	7.692e-81	275.0	COG0500@1|root,COG2226@2|Bacteria,1G5M2@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_5578032_33	326427.Cagg_0674	3.416e-48	188.0	COG1215@1|root,COG1215@2|Bacteria,2G6RJ@200795|Chloroflexi,375GG@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5578032_14	666685.R2APBS1_0246	4.602e-109	355.0	COG0262@1|root,COG0262@2|Bacteria,1MU1W@1224|Proteobacteria,1S2TQ@1236|Gammaproteobacteria,1X4M1@135614|Xanthomonadales	135614|Xanthomonadales	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_5578032_13	670292.JH26_15005	3.063e-113	370.0	COG0384@1|root,COG0384@2|Bacteria,1R9X4@1224|Proteobacteria,2U4TZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	phenazine biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD1_k127_5578032_55	1054213.HMPREF9946_00510	7.865e-05	48.0	COG4221@1|root,COG4221@2|Bacteria,1R9SI@1224|Proteobacteria,2TW8W@28211|Alphaproteobacteria,2JV1G@204441|Rhodospirillales	204441|Rhodospirillales	S	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_5578032_15	383381.EH30_02410	2.208e-107	367.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,2K2YU@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_8
HKD1_k127_5578032_11	102232.GLO73106DRAFT_00020370	4.247e-129	415.0	COG0426@1|root,COG0426@2|Bacteria	2|Bacteria	C	nitric oxide reductase activity	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Fer4,Lactamase_B
HKD1_k127_5578032_52	1267533.KB906738_gene2158	3.549e-06	49.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_5578032_47	639282.DEFDS_0128	1.755e-13	76.0	COG1664@1|root,COG1664@2|Bacteria,2GFXX@200930|Deferribacteres	200930|Deferribacteres	M	Polymer-forming cytoskeletal	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin
HKD1_k127_5578032_23	298654.FraEuI1c_1957	1.073e-74	264.0	COG1077@1|root,COG1077@2|Bacteria,2GMD1@201174|Actinobacteria,4ES3S@85013|Frankiales	201174|Actinobacteria	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_5578032_35	1283284.AZUK01000003_gene3026	1.383e-41	158.0	COG1463@1|root,COG1463@2|Bacteria,1RHH6@1224|Proteobacteria,1S74Q@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Protein of unknown function (DUF3465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3465
HKD1_k127_5578032_22	876269.ARWA01000001_gene2316	8.521e-77	263.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,2VG1Y@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HKD1_k127_5578032_48	688270.Celal_0267	2.221e-12	76.0	2FIGE@1|root,34A8I@2|Bacteria,4P5ED@976|Bacteroidetes,1IA7C@117743|Flavobacteriia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5578032_34	335543.Sfum_1381	3.638e-47	177.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,42RQ6@68525|delta/epsilon subdivisions,2WNCZ@28221|Deltaproteobacteria,2MQEK@213462|Syntrophobacterales	28221|Deltaproteobacteria	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	GO:0000906,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006766,GO:0006767,GO:0006771,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009231,GO:0009987,GO:0016740,GO:0016765,GO:0017144,GO:0018130,GO:0034641,GO:0042364,GO:0042726,GO:0042727,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_5578032_38	204669.Acid345_1215	5.627e-33	133.0	COG0781@1|root,COG0781@2|Bacteria,3Y4Z7@57723|Acidobacteria,2JJFX@204432|Acidobacteriia	204432|Acidobacteriia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD1_k127_5578032_21	290397.Adeh_2736	2.345e-77	283.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1MUAG@1224|Proteobacteria,42M6Q@68525|delta/epsilon subdivisions,2WJ5U@28221|Deltaproteobacteria,2YU8D@29|Myxococcales	28221|Deltaproteobacteria	NT	Signal transducing histidine kinase, homodimeric domain	cheA40H	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HKD1_k127_5578032_50	215803.DB30_5989	3.243e-08	65.0	COG3391@1|root,COG3391@2|Bacteria,1Q2JN@1224|Proteobacteria,4386H@68525|delta/epsilon subdivisions,2X9ZH@28221|Deltaproteobacteria,2YVZH@29|Myxococcales	28221|Deltaproteobacteria	S	Beta-L-arabinofuranosidase, GH127	-	-	-	-	-	-	-	-	-	-	-	-	Laminin_G_3,Stig1
HKD1_k127_5578032_6	234267.Acid_6651	1.499e-184	595.0	COG0154@1|root,COG0154@2|Bacteria,3Y3E5@57723|Acidobacteria	57723|Acidobacteria	J	PFAM Amidase	-	-	-	-	-	-	-	-	-	-	-	-	Amidase
HKD1_k127_5578032_40	1384056.N787_08220	6.036e-25	112.0	COG2062@1|root,COG2062@2|Bacteria,1QVVF@1224|Proteobacteria,1T2K8@1236|Gammaproteobacteria,1XDCD@135614|Xanthomonadales	135614|Xanthomonadales	T	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD1_k127_5578032_1	234267.Acid_5307	0.0	1220.0	COG0508@1|root,COG0567@1|root,COG0508@2|Bacteria,COG0567@2|Bacteria,3Y3EF@57723|Acidobacteria	57723|Acidobacteria	C	2-oxoglutarate dehydrogenase, E1	-	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD1_k127_5578032_31	240016.ABIZ01000001_gene878	8.02e-51	185.0	2AEIE@1|root,314DU@2|Bacteria,46WQ3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5578032_12	485913.Krac_3207	4.494e-121	398.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,2G6TT@200795|Chloroflexi	200795|Chloroflexi	L	Methylated-DNA- protein -cysteine S-methyltransferase DNA binding	ogt	-	2.1.1.63	ko:K00567,ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HKD1_k127_5578032_51	234267.Acid_7938	5.262e-08	64.0	291QZ@1|root,2ZPB0@2|Bacteria,3Y92F@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5578032_56	479434.Sthe_3198	0.0001887	52.0	COG5662@1|root,COG5662@2|Bacteria,2G96Y@200795|Chloroflexi,27YEM@189775|Thermomicrobia	189775|Thermomicrobia	K	Anti-sigma-K factor rskA	-	-	-	-	-	-	-	-	-	-	-	-	RskA,zf-HC2
HKD1_k127_5578032_36	1121920.AUAU01000012_gene2700	4.727e-36	145.0	COG1595@1|root,COG1595@2|Bacteria,3Y5K8@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_5578032_3	1254432.SCE1572_35510	6.212e-197	623.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,42MDU@68525|delta/epsilon subdivisions,2WM9V@28221|Deltaproteobacteria,2YUA7@29|Myxococcales	28221|Deltaproteobacteria	C	Aldehyde dehydrogenase family	gabD	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_5578032_30	1379698.RBG1_1C00001G0519	6.947e-51	192.0	COG0697@1|root,COG0697@2|Bacteria,2NPZZ@2323|unclassified Bacteria	2|Bacteria	EG	EamA-like transporter family	pagO	-	-	ko:K07790	ko02020,map02020	-	-	-	ko00000,ko00001	2.A.7	-	-	EamA
HKD1_k127_5578032_24	1348114.OM33_04140	1.573e-73	261.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,1RYXR@1236|Gammaproteobacteria,2Q1G4@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	S	enzyme related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD1_k127_5578032_20	497964.CfE428DRAFT_2876	2.108e-77	263.0	COG2818@1|root,COG2818@2|Bacteria,46SS9@74201|Verrucomicrobia	74201|Verrucomicrobia	L	Methyladenine glycosylase	-	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD1_k127_5578032_7	1254432.SCE1572_04835	2.248e-166	567.0	COG0642@1|root,COG0745@1|root,COG2202@1|root,COG3447@1|root,COG0745@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3447@2|Bacteria,1NRP8@1224|Proteobacteria,42M0Y@68525|delta/epsilon subdivisions,2WIR4@28221|Deltaproteobacteria,2YUN4@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg,RsbRD_N,SBP_bac_3
HKD1_k127_5578032_39	1250232.JQNJ01000001_gene269	3.238e-32	128.0	COG0662@1|root,COG0662@2|Bacteria,4NTZN@976|Bacteroidetes	976|Bacteroidetes	G	ARD/ARD' family	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5578032_44	1121921.KB898706_gene3013	1.411e-19	101.0	COG0417@1|root,COG0417@2|Bacteria,1QVMG@1224|Proteobacteria,1T2EP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07501	-	-	-	-	ko00000	-	-	-	DNA_pol_B_exo2
HKD1_k127_5578032_10	316067.Geob_1385	7.015e-133	439.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,42NDS@68525|delta/epsilon subdivisions,2WJDE@28221|Deltaproteobacteria,43V4T@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	RmuC family	-	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD1_k127_5578032_26	1304284.L21TH_1713	2.676e-61	243.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,36EE8@31979|Clostridiaceae	186801|Clostridia	L	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_5578032_32	756272.Plabr_4030	8.235e-51	184.0	COG2318@1|root,COG2318@2|Bacteria	2|Bacteria	S	DinB family	ywlC1	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_5578032_0	504472.Slin_5713	0.0	1270.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,4NGU2@976|Bacteroidetes,47NFD@768503|Cytophagia	976|Bacteroidetes	M	Tricorn protease homolog	-	-	-	-	-	-	-	-	-	-	-	-	GRASP55_65,PD40,PDZ_2,Peptidase_S41,Tricorn_C1
HKD1_k127_5578032_37	1340493.JNIF01000003_gene2238	1.737e-35	143.0	2E5IZ@1|root,330AA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5578032_43	452637.Oter_0059	3.019e-20	98.0	2E32R@1|root,32Y2Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5578032_5	247490.KSU1_C0443	1.071e-192	623.0	COG0526@1|root,COG3391@1|root,COG0526@2|Bacteria,COG3391@2|Bacteria,2IXWV@203682|Planctomycetes	203682|Planctomycetes	CO	PFAM NHL repeat	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Thioredoxin_8
HKD1_k127_5578032_17	1121920.AUAU01000012_gene2631	1.626e-104	377.0	COG1629@1|root,COG4771@2|Bacteria,3Y3ZU@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_5578032_8	886293.Sinac_4749	3.247e-161	522.0	COG1167@1|root,COG1167@2|Bacteria,2IYEU@203682|Planctomycetes	203682|Planctomycetes	K	COG1167 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD1_k127_5578032_53	1121438.JNJA01000005_gene1065	1.12e-05	53.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,42M03@68525|delta/epsilon subdivisions,2WIT0@28221|Deltaproteobacteria,2M8VA@213115|Desulfovibrionales	28221|Deltaproteobacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K02481,ko:K07712	ko02020,map02020	M00497	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_5578032_42	285514.JNWO01000007_gene3905	1.138e-20	97.0	2D579@1|root,32TID@2|Bacteria,2IMWE@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5578032_27	1122604.JONR01000032_gene93	8.949e-61	223.0	COG0657@1|root,COG0657@2|Bacteria,1N5QB@1224|Proteobacteria,1SZEF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5579860_3	204669.Acid345_4390	7.078e-75	276.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_5579860_0	1340493.JNIF01000003_gene3421	3.539e-251	811.0	COG1629@1|root,COG1629@2|Bacteria,3Y67H@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_5579860_5	1173025.GEI7407_0339	2.784e-17	89.0	COG0438@1|root,COG0457@1|root,COG0859@1|root,COG0438@2|Bacteria,COG0457@2|Bacteria,COG0859@2|Bacteria,1G193@1117|Cyanobacteria,1H799@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	DUF4915,Glyco_transf_9,Glycos_transf_1,TPR_1,TPR_11,TPR_16,TPR_17,TPR_2,TPR_8
HKD1_k127_5579860_4	234267.Acid_1209	1.665e-62	220.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_5579860_2	1267535.KB906767_gene1129	3.263e-146	498.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_5579860_1	1340493.JNIF01000003_gene3421	1.168e-239	775.0	COG1629@1|root,COG1629@2|Bacteria,3Y67H@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_5626142_0	1173022.Cri9333_3469	2.459e-280	874.0	COG1506@1|root,COG1506@2|Bacteria,1G200@1117|Cyanobacteria,1H8T3@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Prolyl oligopeptidase family	dap2	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_5626142_6	1278073.MYSTI_02601	1.39e-44	186.0	COG1858@1|root,COG1858@2|Bacteria,1MWAT@1224|Proteobacteria	1224|Proteobacteria	C	cytochrome c peroxidase	-	-	-	-	-	-	-	-	-	-	-	-	CCP_MauG
HKD1_k127_5626142_10	1273538.G159_18750	1.357e-09	64.0	COG0494@1|root,COG0494@2|Bacteria,1V92F@1239|Firmicutes,4HJSB@91061|Bacilli,26HIT@186818|Planococcaceae	91061|Bacilli	L	NUDIX domain	-	-	3.6.1.55	ko:K03574	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	NUDIX
HKD1_k127_5626142_11	479434.Sthe_0717	9.908e-09	63.0	2BCVK@1|root,326GC@2|Bacteria,2G9HU@200795|Chloroflexi	200795|Chloroflexi	S	Protein of unknown function (DUF3995)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3995
HKD1_k127_5626142_7	105559.Nwat_2878	1.158e-41	160.0	COG1278@1|root,COG3326@1|root,COG1278@2|Bacteria,COG3326@2|Bacteria,1N6YM@1224|Proteobacteria,1SCMX@1236|Gammaproteobacteria,1WZHU@135613|Chromatiales	135613|Chromatiales	K	Cold-shock protein, DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CSD,DUF1294
HKD1_k127_5626142_8	253839.SSNG_05685	2.573e-40	158.0	COG1216@1|root,COG1216@2|Bacteria,2IAFY@201174|Actinobacteria	201174|Actinobacteria	S	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5626142_9	509191.AEDB02000021_gene3093	5.355e-14	79.0	2DUSW@1|root,33S3K@2|Bacteria,1VSAF@1239|Firmicutes,24Y1P@186801|Clostridia,3WP0N@541000|Ruminococcaceae	509191.AEDB02000021_gene3093|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5626142_1	204669.Acid345_1052	3.351e-162	543.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_5626142_5	234267.Acid_1209	1.652e-58	209.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_5626142_3	285535.JOEY01000004_gene10229	7.59e-70	253.0	COG0671@1|root,COG0671@2|Bacteria,2I8WW@201174|Actinobacteria	201174|Actinobacteria	I	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD1_k127_5626142_4	234267.Acid_7686	2.12e-60	218.0	2F2X8@1|root,33VSU@2|Bacteria,3Y7XB@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5626142_2	1340493.JNIF01000003_gene1504	1.804e-119	391.0	COG1131@1|root,COG1131@2|Bacteria,3Y4YH@57723|Acidobacteria	57723|Acidobacteria	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5658301_29	111780.Sta7437_4112	1.904e-32	150.0	COG4932@1|root,COG4932@2|Bacteria,1GIGP@1117|Cyanobacteria,3VKF3@52604|Pleurocapsales	1117|Cyanobacteria	M	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
HKD1_k127_5658301_28	595593.JREV01000009_gene1225	3.3e-37	166.0	COG3291@1|root,COG3391@1|root,COG3291@2|Bacteria,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_34	344747.PM8797T_11761	2.233e-21	113.0	COG1572@1|root,COG2931@1|root,COG3210@1|root,COG1572@2|Bacteria,COG2931@2|Bacteria,COG3210@2|Bacteria,2J30Y@203682|Planctomycetes	203682|Planctomycetes	U	Extracellular nuclease	-	-	-	-	-	-	-	-	-	-	-	-	Chlam_PMP
HKD1_k127_5658301_15	706587.Desti_5511	1.442e-82	316.0	COG0726@1|root,COG0726@2|Bacteria,1QZSR@1224|Proteobacteria,43D4Q@68525|delta/epsilon subdivisions	1224|Proteobacteria	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_5658301_33	1463900.JOIX01000001_gene6546	2.784e-23	120.0	COG3209@1|root,COG3391@1|root,COG3468@1|root,COG3209@2|Bacteria,COG3391@2|Bacteria,COG3468@2|Bacteria,2H4SV@201174|Actinobacteria	201174|Actinobacteria	MU	Bacterial Ig-like domain (group 3)	-	-	-	ko:K20276	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	Big_3_5,TIG
HKD1_k127_5658301_18	204669.Acid345_2450	7.507e-72	281.0	COG1572@1|root,COG1572@2|Bacteria	2|Bacteria	NU	bacterial-type flagellum-dependent cell motility	-	-	-	-	-	-	-	-	-	-	-	-	CARDB,Collagen,fn3
HKD1_k127_5658301_30	1121373.KB903632_gene508	1.443e-31	145.0	COG1520@1|root,COG1520@2|Bacteria,4NNUN@976|Bacteroidetes,47Q36@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 8 (cellulase D) family	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,I-set,Ig_3,SBBP
HKD1_k127_5658301_41	755178.Cyan10605_0318	3.978e-07	64.0	COG2931@1|root,COG3240@1|root,COG2931@2|Bacteria,COG3240@2|Bacteria	2|Bacteria	I	lipase activity	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HemolysinCabind,Lipase_GDSL,PPC
HKD1_k127_5658301_17	760192.Halhy_5168	2.263e-74	253.0	COG4675@1|root,COG4675@2|Bacteria,4NQJR@976|Bacteroidetes,1IT97@117747|Sphingobacteriia	976|Bacteroidetes	S	Tail Collar domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Collar
HKD1_k127_5658301_21	234267.Acid_0150	1.31e-64	225.0	COG4675@1|root,COG4675@2|Bacteria,3Y4U8@57723|Acidobacteria	57723|Acidobacteria	S	PFAM Phage tail collar	-	-	-	-	-	-	-	-	-	-	-	-	Collar
HKD1_k127_5658301_20	754035.Mesau_00887	4.655e-65	226.0	COG4675@1|root,COG4675@2|Bacteria,1MZY9@1224|Proteobacteria,2UB9G@28211|Alphaproteobacteria,43MIF@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Tail Collar domain	-	-	-	-	-	-	-	-	-	-	-	-	Collar
HKD1_k127_5658301_43	329726.AM1_3687	7.111e-05	51.0	2EJ72@1|root,33CY7@2|Bacteria,1GB8K@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_27	686340.Metal_2137	2.669e-37	147.0	COG0454@1|root,COG0456@2|Bacteria,1N29T@1224|Proteobacteria,1S8SC@1236|Gammaproteobacteria,1XFVH@135618|Methylococcales	135618|Methylococcales	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_5658301_38	234267.Acid_0146	8.55e-13	72.0	2A09M@1|root,30ND1@2|Bacteria,3Y8YR@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_35	330214.NIDE1411	1.341e-20	107.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23,Methyltransf_25,Methyltransf_31
HKD1_k127_5658301_31	1297865.APJD01000003_gene6126	1.577e-30	126.0	COG0454@1|root,COG0456@2|Bacteria,1N29T@1224|Proteobacteria,2UF3Q@28211|Alphaproteobacteria,3JYMP@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	FR47-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_5658301_42	1297865.APJD01000003_gene6125	1.419e-05	54.0	2E9MA@1|root,333TZ@2|Bacteria,1NBIS@1224|Proteobacteria,2UI51@28211|Alphaproteobacteria,3JZD4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_26	1340493.JNIF01000003_gene3663	3.159e-43	164.0	COG0782@1|root,COG0782@2|Bacteria,3Y49X@57723|Acidobacteria	57723|Acidobacteria	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_5658301_36	511051.CSE_09940	1.431e-18	94.0	COG0526@1|root,COG0526@2|Bacteria	2|Bacteria	CO	cell redox homeostasis	resA	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Thioredoxin_8
HKD1_k127_5658301_24	179408.Osc7112_2910	5.43e-52	204.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,1FZWQ@1117|Cyanobacteria,1H6WA@1150|Oscillatoriales	1117|Cyanobacteria	KLT	PFAM Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase,TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_5658301_7	765420.OSCT_2674	1.386e-125	441.0	COG0842@1|root,COG1131@1|root,COG1716@1|root,COG0842@2|Bacteria,COG1131@2|Bacteria,COG1716@2|Bacteria,2G7J8@200795|Chloroflexi,374RZ@32061|Chloroflexia	32061|Chloroflexia	V	ABC transporter related	-	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane,ABC_tran,FHA
HKD1_k127_5658301_39	1267535.KB906767_gene854	3.152e-10	72.0	COG0457@1|root,COG0457@2|Bacteria	1267535.KB906767_gene854|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_23	448385.sce2235	5.302e-54	214.0	COG0515@1|root,COG0515@2|Bacteria	448385.sce2235|-	KLT	protein kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_2	401053.AciPR4_3119	2.705e-285	899.0	COG0495@1|root,COG0495@2|Bacteria,3Y37K@57723|Acidobacteria,2JIGF@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_5658301_19	234267.Acid_5984	1.725e-66	236.0	COG0648@1|root,COG0648@2|Bacteria,3Y35C@57723|Acidobacteria	57723|Acidobacteria	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_5658301_13	1382359.JIAL01000001_gene2337	6.95e-98	335.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria,2JI1H@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_5658301_10	204669.Acid345_0712	1.16e-120	399.0	COG0115@1|root,COG0115@2|Bacteria,3Y32X@57723|Acidobacteria,2JI58@204432|Acidobacteriia	204432|Acidobacteriia	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_5658301_0	886293.Sinac_1249	0.0	2651.0	COG3459@1|root,COG3459@2|Bacteria,2IYJ0@203682|Planctomycetes	203682|Planctomycetes	G	Putative glucoamylase	-	-	-	ko:K13688	-	-	-	-	ko00000,ko01000,ko01003	-	GH94,GT84	-	Glyco_hydro_36,Glyco_transf_36,Glycoamylase
HKD1_k127_5658301_32	573063.Metin_0198	5.288e-25	111.0	COG2314@1|root,COG3815@1|root,arCOG03293@2157|Archaea,arCOG03949@2157|Archaea,2XYU1@28890|Euryarchaeota,23RS2@183939|Methanococci	183939|Methanococci	S	Predicted membrane protein (DUF2085)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5658301_8	1267535.KB906767_gene3449	1.054e-124	409.0	COG1494@1|root,COG1494@2|Bacteria,3Y2XJ@57723|Acidobacteria,2JKWZ@204432|Acidobacteriia	204432|Acidobacteriia	G	Bacterial fructose-1,6-bisphosphatase, glpX-encoded	-	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD1_k127_5658301_6	1382315.JPOI01000001_gene466	1.107e-160	516.0	COG1960@1|root,COG1960@2|Bacteria,1TPVK@1239|Firmicutes,4HA7B@91061|Bacilli,1WERN@129337|Geobacillus	91061|Bacilli	C	Acyl-CoA dehydrogenase, N-terminal domain	B4168_2380	-	1.3.99.32	ko:K16173	ko00362,ko01120,map00362,map01120	-	R05579	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_5658301_37	443255.SCLAV_1174	2.245e-14	80.0	COG1917@1|root,COG1917@2|Bacteria,2IRV4@201174|Actinobacteria	201174|Actinobacteria	L	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_5658301_16	1267535.KB906767_gene4240	4.013e-79	289.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HKD1_k127_5658301_12	1469245.JFBG01000027_gene1490	4.622e-105	357.0	COG0617@1|root,COG0617@2|Bacteria,1MU2X@1224|Proteobacteria,1RPFJ@1236|Gammaproteobacteria,1WWKR@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'- nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases	cca	-	2.7.7.72	ko:K00974	ko03013,map03013	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd
HKD1_k127_5658301_14	469371.Tbis_1027	2.049e-86	295.0	COG3186@1|root,COG3186@2|Bacteria,2GKCB@201174|Actinobacteria,4E9MH@85010|Pseudonocardiales	201174|Actinobacteria	E	Biopterin-dependent aromatic amino acid hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HKD1_k127_5658301_3	926566.Terro_1277	8.608e-277	886.0	COG1629@1|root,COG4771@2|Bacteria,3Y2QR@57723|Acidobacteria,2JKKF@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_5658301_9	44251.PDUR_03260	5.316e-122	399.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,4HAMU@91061|Bacilli,272BF@186822|Paenibacillaceae	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_5658301_11	1382306.JNIM01000001_gene1003	1.743e-105	357.0	COG0626@1|root,COG0626@2|Bacteria,2G684@200795|Chloroflexi	200795|Chloroflexi	E	PFAM Cys Met metabolism	-	-	2.5.1.48,4.4.1.11	ko:K01739,ko:K01761	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00654,R00999,R01288,R02508,R03217,R03260,R04770,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00196,RC00348,RC00420,RC01209,RC01210,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_5658301_25	1268072.PSAB_02815	2.439e-43	164.0	COG1310@1|root,COG1310@2|Bacteria,1VKT4@1239|Firmicutes	1239|Firmicutes	S	JAB/MPN domain	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
HKD1_k127_5658301_4	44251.PDUR_03270	3.496e-196	623.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,4HBGP@91061|Bacilli,271Z6@186822|Paenibacillaceae	91061|Bacilli	H	ThiS family	-	-	2.7.7.80,2.8.1.11	ko:K21029,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	Rhodanese,ThiF,ThiS
HKD1_k127_5658301_22	929556.Solca_0458	4.519e-54	199.0	COG1413@1|root,COG1413@2|Bacteria	2|Bacteria	C	deoxyhypusine monooxygenase activity	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2
HKD1_k127_5658301_1	324602.Caur_2963	0.0	1181.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,2G5W2@200795|Chloroflexi,376J5@32061|Chloroflexia	32061|Chloroflexia	H	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_5658301_5	234267.Acid_5495	3.951e-168	537.0	COG1228@1|root,COG1228@2|Bacteria	2|Bacteria	Q	imidazolonepropionase activity	-	-	1.13.12.3	ko:K00466	ko00380,map00380	-	R00679	RC00213	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_5684666_1	234267.Acid_1818	4.864e-208	668.0	COG3590@1|root,COG3590@2|Bacteria,3Y31X@57723|Acidobacteria	57723|Acidobacteria	O	PFAM peptidase M13	-	-	3.4.24.71	ko:K01415	-	-	-	-	ko00000,ko01000,ko01002,ko04147	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD1_k127_5684666_2	761193.Runsl_5388	7.124e-78	271.0	COG3358@1|root,COG3358@2|Bacteria,4NFT3@976|Bacteroidetes,47NJY@768503|Cytophagia	976|Bacteroidetes	S	Protein of unknown function (DUF1684)	-	-	-	ko:K09164	-	-	-	-	ko00000	-	-	-	DUF1684
HKD1_k127_5684666_3	234267.Acid_4617	2.475e-46	179.0	COG0457@1|root,COG0457@2|Bacteria,3Y4T0@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF2911)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2911
HKD1_k127_5684666_4	945713.IALB_0606	8.278e-43	169.0	COG0457@1|root,COG0457@2|Bacteria	945713.IALB_0606|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5684666_0	234267.Acid_5975	9.602e-295	931.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,3Y3V0@57723|Acidobacteria	2|Bacteria	EU	peptidase S9B dipeptidylpeptidase IV domain protein	ptpA_1	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD1_k127_5684666_6	1121878.AUGL01000006_gene519	1.138e-22	113.0	COG4403@1|root,COG4403@2|Bacteria,1RF58@1224|Proteobacteria,1S4EP@1236|Gammaproteobacteria	1236|Gammaproteobacteria	V	Lanthionine synthetase C family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5684666_5	1267535.KB906767_gene1297	1.166e-23	116.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_5703806_5	316274.Haur_2944	1.067e-168	537.0	COG1830@1|root,COG1830@2|Bacteria,2G8VI@200795|Chloroflexi	200795|Chloroflexi	G	DeoC/LacD family aldolase	-	-	4.1.2.13	ko:K11645	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD1_k127_5703806_18	1123399.AQVE01000001_gene529	7.932e-49	185.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Metallophosphoesterase	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_5703806_24	1267533.KB906734_gene3934	3.802e-29	124.0	COG0558@1|root,COG0558@2|Bacteria,3Y4S5@57723|Acidobacteria,2JJ9R@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.41	ko:K08744	ko00564,ko01100,map00564,map01100	-	R02030	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_5703806_1	1191523.MROS_2418	8.694e-259	812.0	COG0443@1|root,COG0443@2|Bacteria	2|Bacteria	O	unfolded protein binding	dnaK	GO:0000166,GO:0000988,GO:0000989,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006457,GO:0006458,GO:0006950,GO:0006986,GO:0008144,GO:0008150,GO:0008270,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010033,GO:0010556,GO:0016020,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0016989,GO:0017076,GO:0017111,GO:0018995,GO:0019219,GO:0019222,GO:0020003,GO:0022607,GO:0030430,GO:0030554,GO:0031323,GO:0031326,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0033554,GO:0033643,GO:0033646,GO:0033655,GO:0034620,GO:0035639,GO:0035966,GO:0035967,GO:0036094,GO:0042221,GO:0043167,GO:0043168,GO:0043169,GO:0043226,GO:0043227,GO:0043230,GO:0043531,GO:0043656,GO:0043657,GO:0043933,GO:0044085,GO:0044183,GO:0044215,GO:0044216,GO:0044217,GO:0044421,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051082,GO:0051084,GO:0051085,GO:0051087,GO:0051171,GO:0051252,GO:0051716,GO:0060255,GO:0061077,GO:0065003,GO:0065007,GO:0065010,GO:0070887,GO:0071310,GO:0071840,GO:0071944,GO:0080090,GO:0097159,GO:0097367,GO:0140110,GO:1901265,GO:1901363,GO:1903506,GO:2001141	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_5703806_8	1382359.JIAL01000001_gene2461	1.385e-116	386.0	COG0484@1|root,COG0484@2|Bacteria,3Y2XW@57723|Acidobacteria,2JHWV@204432|Acidobacteriia	204432|Acidobacteriia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	-	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_5703806_22	204669.Acid345_0975	2.312e-36	142.0	COG0789@1|root,COG0789@2|Bacteria,3Y4KX@57723|Acidobacteria,2JJA1@204432|Acidobacteriia	204432|Acidobacteriia	K	MerR HTH family regulatory protein	-	-	-	ko:K13640	-	-	-	-	ko00000,ko03000	-	-	-	MerR_1
HKD1_k127_5703806_20	1177179.A11A3_00715	7.326e-42	155.0	COG1359@1|root,COG1359@2|Bacteria,1N1AN@1224|Proteobacteria,1S750@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5703806_0	1379270.AUXF01000003_gene3550	0.0	1599.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_5703806_13	1340493.JNIF01000003_gene4178	4.702e-77	292.0	COG1629@1|root,COG3485@1|root,COG3485@2|Bacteria,COG4771@2|Bacteria,3Y3SU@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_5703806_25	1156935.QWE_16848	5.095e-23	103.0	2E8GZ@1|root,332V8@2|Bacteria,1NDF5@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5703806_26	1340493.JNIF01000003_gene2178	9.646e-20	90.0	COG1231@1|root,COG1231@2|Bacteria,3Y2HW@57723|Acidobacteria	57723|Acidobacteria	E	PFAM amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD1_k127_5703806_17	211165.AJLN01000116_gene3145	4.82e-63	223.0	COG0500@1|root,COG2226@2|Bacteria,1G9FG@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methylase involved in ubiquinone menaquinone biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_5703806_34	398767.Glov_2773	0.0001433	53.0	COG0745@1|root,COG0745@2|Bacteria,1NQ8U@1224|Proteobacteria,42XVU@68525|delta/epsilon subdivisions,2WTFF@28221|Deltaproteobacteria,43VV3@69541|Desulfuromonadales	28221|Deltaproteobacteria	KT	Domain of unknown function (DUF4388)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4388
HKD1_k127_5703806_28	349124.Hhal_0037	6.923e-17	92.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,1WWWR@135613|Chromatiales	135613|Chromatiales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_5703806_27	56107.Cylst_1276	1.356e-17	92.0	COG1876@1|root,COG1876@2|Bacteria,1G4P0@1117|Cyanobacteria,1HIMP@1161|Nostocales	1117|Cyanobacteria	M	peptidase M15B and M15C DD-carboxypeptidase VanY	-	-	-	-	-	-	-	-	-	-	-	-	VanY
HKD1_k127_5703806_29	1340493.JNIF01000003_gene4496	1.014e-16	94.0	COG0457@1|root,COG0457@2|Bacteria,3Y2IP@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_5703806_14	485918.Cpin_0998	1.933e-75	263.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	ligD	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_5703806_2	861299.J421_4036	9.24e-220	706.0	COG4774@1|root,COG4774@2|Bacteria,1ZTSY@142182|Gemmatimonadetes	142182|Gemmatimonadetes	P	TonB dependent receptor	-	-	-	ko:K16090	-	-	-	-	ko00000,ko02000	1.B.14.1.11	-	-	Plug,TonB_dep_Rec
HKD1_k127_5703806_4	525897.Dbac_1184	4.086e-206	653.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1MVRR@1224|Proteobacteria,42NSC@68525|delta/epsilon subdivisions,2WMAX@28221|Deltaproteobacteria,2MBD3@213115|Desulfovibrionales	28221|Deltaproteobacteria	CE	PFAM FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
HKD1_k127_5703806_15	1396418.BATQ01000007_gene1447	6.791e-72	261.0	2DR4U@1|root,33A62@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	CreD
HKD1_k127_5703806_3	1081640.AGFU01000011_gene1303	1.023e-216	684.0	COG1032@1|root,COG1032@2|Bacteria,1MY2Y@1224|Proteobacteria,2TUIT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_5703806_7	867903.ThesuDRAFT_01903	1.265e-131	430.0	COG0644@1|root,COG0644@2|Bacteria,1TRTQ@1239|Firmicutes,24E1W@186801|Clostridia	186801|Clostridia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3,Lycopene_cycl
HKD1_k127_5703806_21	1128421.JAGA01000001_gene2145	1.776e-37	145.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	MA20_05735	-	-	-	-	-	-	-	-	-	-	-	HTH_34
HKD1_k127_5703806_16	1128421.JAGA01000001_gene2144	8.49e-64	224.0	COG3127@1|root,COG3127@2|Bacteria	2|Bacteria	Q	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_5703806_23	1040989.AWZU01000109_gene140	9.087e-33	129.0	COG2146@1|root,COG2146@2|Bacteria,1N8PE@1224|Proteobacteria,2UF7G@28211|Alphaproteobacteria,3JZH1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710,ko:K14578	ko00360,ko00624,ko00626,ko00627,ko00633,ko00642,ko01100,ko01120,ko01220,map00360,map00624,map00626,map00627,map00633,map00642,map01100,map01120,map01220	M00534,M00545,M00638	R02968,R05422,R05423,R05424,R05425,R05426,R05427,R06782,R06783,R06909,R06930,R06937,R07704,R07706,R07709,R07710,R09159,R09233	RC00091,RC00098,RC00157,RC00274,RC00275,RC00490,RC01376,RC01377,RC01801	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD1_k127_5703806_6	1122604.JONR01000045_gene2500	2.33e-133	434.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,1SZK5@1236|Gammaproteobacteria,1XCD9@135614|Xanthomonadales	135614|Xanthomonadales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
HKD1_k127_5703806_30	1298864.AUEQ01000001_gene4109	9.808e-10	67.0	2BFJA@1|root,329DA@2|Bacteria,2H9JX@201174|Actinobacteria,23EDR@1762|Mycobacteriaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5703806_9	1168059.KB899087_gene2989	1.565e-115	375.0	COG0450@1|root,COG0450@2|Bacteria,1MX2B@1224|Proteobacteria,2TT09@28211|Alphaproteobacteria,3EYMY@335928|Xanthobacteraceae	28211|Alphaproteobacteria	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	1-cysPrx_C,AhpC-TSA
HKD1_k127_5703806_11	1198114.AciX9_0682	1.364e-88	299.0	COG3494@1|root,COG3494@2|Bacteria,3Y3KI@57723|Acidobacteria,2JIMV@204432|Acidobacteriia	204432|Acidobacteriia	S	Protein of unknown function (DUF1009)	-	-	-	ko:K09949	-	-	-	-	ko00000	-	-	-	DUF1009
HKD1_k127_5703806_12	234267.Acid_6203	1.756e-83	284.0	COG1043@1|root,COG1043@2|Bacteria,3Y33C@57723|Acidobacteria	57723|Acidobacteria	M	Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell	lpxA	-	2.3.1.129	ko:K00677	ko00540,ko01100,ko01503,map00540,map01100,map01503	M00060	R04567	RC00039,RC00055	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Acetyltransf_11,Hexapep
HKD1_k127_5703806_19	1198114.AciX9_0678	1.659e-45	169.0	COG0764@1|root,COG0764@2|Bacteria,3Y4CG@57723|Acidobacteria,2JJ97@204432|Acidobacteriia	204432|Acidobacteriia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_5703806_31	240015.ACP_2420	2.487e-09	68.0	COG2825@1|root,COG2825@2|Bacteria,3Y4WC@57723|Acidobacteria,2JJHF@204432|Acidobacteriia	204432|Acidobacteriia	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD1_k127_5703806_32	926566.Terro_0306	3.924e-09	65.0	COG2825@1|root,COG2825@2|Bacteria,3Y4WC@57723|Acidobacteria,2JJHF@204432|Acidobacteriia	204432|Acidobacteriia	M	Outer membrane protein (OmpH-like)	-	-	-	ko:K06142	-	-	-	-	ko00000	-	-	-	OmpH
HKD1_k127_5703806_10	1382359.JIAL01000001_gene805	6.053e-89	319.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_5710273_2	1403819.BATR01000181_gene6180	1.285e-143	463.0	COG2805@1|root,COG2805@2|Bacteria,46ZKR@74201|Verrucomicrobia,2IVJW@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD1_k127_5710273_4	1396418.BATQ01000046_gene6165	9.461e-128	418.0	COG2805@1|root,COG2805@2|Bacteria,46XD7@74201|Verrucomicrobia,2IVHZ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	NU	Type II/IV secretion system protein	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD1_k127_5710273_0	1304885.AUEY01000078_gene1047	8.869e-201	649.0	COG3664@1|root,COG3664@2|Bacteria,1NSK2@1224|Proteobacteria	1224|Proteobacteria	G	F5/8 type C domain	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
HKD1_k127_5710273_11	1396141.BATP01000016_gene2783	2.283e-11	72.0	2BN1X@1|root,32GN2@2|Bacteria,46XN3@74201|Verrucomicrobia,2IW8A@203494|Verrucomicrobiae	203494|Verrucomicrobiae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5710273_3	497964.CfE428DRAFT_3886	2.09e-131	430.0	COG4124@1|root,COG4124@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 26 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HKD1_k127_5710273_9	497964.CfE428DRAFT_0192	2.816e-34	139.0	COG1595@1|root,COG1595@2|Bacteria,46WAM@74201|Verrucomicrobia	74201|Verrucomicrobia	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_5710273_15	452637.Oter_1653	1.487e-06	57.0	2C12Z@1|root,2ZUMU@2|Bacteria,46WS3@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5710273_14	1147.D082_08720	1.141e-07	63.0	COG0265@1|root,COG0265@2|Bacteria,1G0U4@1117|Cyanobacteria,1H56E@1142|Synechocystis	1117|Cyanobacteria	O	Trypsin	htrA	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_5710273_1	481448.Minf_1075	2.62e-185	591.0	COG0004@1|root,COG0004@2|Bacteria,46SCE@74201|Verrucomicrobia,37FY5@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	P	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_5710273_10	794903.OPIT5_10435	2.737e-27	120.0	2EHW5@1|root,33BMQ@2|Bacteria,46WAC@74201|Verrucomicrobia,3K9R0@414999|Opitutae	414999|Opitutae	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5710273_12	1267535.KB906767_gene5189	1.766e-09	68.0	COG0457@1|root,COG0457@2|Bacteria,3Y3BD@57723|Acidobacteria	57723|Acidobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_5710273_7	1121937.AUHJ01000010_gene1639	1.036e-81	305.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,1RMTG@1236|Gammaproteobacteria,4651V@72275|Alteromonadaceae	1236|Gammaproteobacteria	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD1_k127_5710273_6	234267.Acid_7916	1.414e-123	433.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria	234267.Acid_7916|-	S	cAMP biosynthetic process	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	-
HKD1_k127_5710273_8	1123242.JH636435_gene2613	3.81e-50	192.0	COG1595@1|root,COG1595@2|Bacteria,2IZZP@203682|Planctomycetes	203682|Planctomycetes	K	Sigma-70 region 2	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2
HKD1_k127_5710273_5	1123070.KB899261_gene2104	1.562e-125	407.0	COG4864@1|root,COG4864@2|Bacteria,46TWZ@74201|Verrucomicrobia,2ITH8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	SigmaW regulon antibacterial	-	-	-	-	-	-	-	-	-	-	-	-	YdfA_immunity
HKD1_k127_5845468_9	247490.KSU1_C1161	2.704e-49	198.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	yidC	-	-	ko:K03217,ko:K06872	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,DUF4124,PDZ_2,Peptidase_C11,SLH,TPM_phosphatase,TPR_11,Trypsin_2,YidC_periplas
HKD1_k127_5845468_15	671143.DAMO_2346	1.096e-24	119.0	COG0484@1|root,COG3307@1|root,COG0484@2|Bacteria,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	DnaJ,Wzy_C
HKD1_k127_5845468_6	580331.Thit_0132	5.367e-71	261.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,42EVR@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD1_k127_5845468_2	1403819.BATR01000002_gene60	7.78e-105	355.0	COG0438@1|root,COG0438@2|Bacteria,46VRS@74201|Verrucomicrobia,2IW1F@203494|Verrucomicrobiae	203494|Verrucomicrobiae	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4
HKD1_k127_5845468_1	880071.Fleli_3574	1.675e-189	613.0	COG2192@1|root,COG2192@2|Bacteria,4NEV9@976|Bacteroidetes,47JR5@768503|Cytophagia	976|Bacteroidetes	O	PFAM Carbamoyltransferase	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD1_k127_5845468_18	439235.Dalk_4189	1.688e-12	79.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_5845468_4	118168.MC7420_2113	1.774e-87	297.0	COG0463@1|root,COG0463@2|Bacteria,1G20E@1117|Cyanobacteria,1H9C4@1150|Oscillatoriales	1117|Cyanobacteria	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5845468_11	278963.ATWD01000001_gene1919	4.482e-38	159.0	2C79F@1|root,306NW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5845468_7	314232.SKA53_01024	1.078e-67	249.0	COG0438@1|root,COG0438@2|Bacteria,1MWEM@1224|Proteobacteria,2U1NW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_5845468_21	756272.Plabr_4186	2.956e-06	60.0	2C35F@1|root,32RBK@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5845468_17	1269813.ATUL01000040_gene1383	3.284e-13	81.0	COG0438@1|root,COG0438@2|Bacteria,1NAE9@1224|Proteobacteria	1224|Proteobacteria	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_5845468_13	1353537.TP2_17360	3.039e-27	127.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2TQJM@28211|Alphaproteobacteria,2XMET@285107|Thioclava	28211|Alphaproteobacteria	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_5845468_12	1469607.KK073769_gene5983	5.831e-34	143.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	tuaG	GO:0003674,GO:0003824,GO:0016740,GO:0016757	-	ko:K16698	-	-	-	-	ko00000,ko01000,ko01003	-	GT2	iYO844.BSU35550	Glycos_transf_2
HKD1_k127_5845468_16	1242864.D187_007138	1.378e-17	95.0	COG0438@1|root,COG0438@2|Bacteria,1QU2N@1224|Proteobacteria,42PY5@68525|delta/epsilon subdivisions,2WIU8@28221|Deltaproteobacteria,2YVJ5@29|Myxococcales	28221|Deltaproteobacteria	M	Glycosyl transferases group 1	tuaH	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HKD1_k127_5845468_22	1122978.AUFP01000002_gene2048	6.601e-05	55.0	COG2244@1|root,COG2244@2|Bacteria,4NT7E@976|Bacteroidetes,2FXBN@200643|Bacteroidia	976|Bacteroidetes	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_5845468_10	1172179.AUKV01000002_gene763	6.196e-45	173.0	COG2242@1|root,COG2242@2|Bacteria,2HRNT@201174|Actinobacteria	201174|Actinobacteria	H	Methyltransferase FkbM domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_21
HKD1_k127_5845468_3	671143.DAMO_0194	1.203e-100	359.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HKD1_k127_5845468_14	1121403.AUCV01000014_gene4607	3.864e-27	123.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42MNP@68525|delta/epsilon subdivisions,2WMJZ@28221|Deltaproteobacteria,2MJAM@213118|Desulfobacterales	28221|Deltaproteobacteria	M	export protein	wza2	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_5845468_20	100226.SCO7093	6.555e-09	66.0	COG2909@1|root,COG2909@2|Bacteria,2GJXF@201174|Actinobacteria	201174|Actinobacteria	K	luxR family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,GerE
HKD1_k127_5845468_0	234267.Acid_4760	2.056e-271	863.0	COG0249@1|root,COG0249@2|Bacteria,3Y2J5@57723|Acidobacteria	57723|Acidobacteria	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD1_k127_5845468_5	234267.Acid_3351	1.339e-81	283.0	COG0142@1|root,COG0142@2|Bacteria,3Y2VJ@57723|Acidobacteria	57723|Acidobacteria	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_5845468_8	1382359.JIAL01000001_gene117	2.877e-59	209.0	COG1666@1|root,COG1666@2|Bacteria,3Y4I3@57723|Acidobacteria,2JJ8P@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the UPF0234 family	-	-	-	ko:K09767	-	-	-	-	ko00000	-	-	-	DUF520
HKD1_k127_5891275_6	204669.Acid345_2140	6.949e-51	186.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,3Y466@57723|Acidobacteria,2JHTM@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03742	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_5891275_7	234267.Acid_1059	8.532e-45	168.0	COG0691@1|root,COG0691@2|Bacteria,3Y4CC@57723|Acidobacteria	57723|Acidobacteria	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_5891275_2	1340493.JNIF01000004_gene57	1.365e-138	456.0	COG0260@1|root,COG0260@2|Bacteria,3Y33T@57723|Acidobacteria	57723|Acidobacteria	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD1_k127_5891275_12	985665.HPL003_27460	5.899e-14	82.0	COG0484@1|root,COG0484@2|Bacteria,1VAWE@1239|Firmicutes,4HXR3@91061|Bacilli,26Z8U@186822|Paenibacillaceae	91061|Bacilli	O	molecular chaperone	dnaJ3	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ
HKD1_k127_5891275_14	269797.Mbar_A0925	3.275e-10	70.0	COG1413@1|root,arCOG02966@2157|Archaea	2157|Archaea	C	PBS lyase HEAT domain protein repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HEAT_2,HEAT_PBS
HKD1_k127_5891275_1	204669.Acid345_0710	4.765e-139	455.0	COG0542@1|root,COG0542@2|Bacteria,3Y463@57723|Acidobacteria,2JMAK@204432|Acidobacteriia	204432|Acidobacteriia	O	C-terminal, D2-small domain, of ClpB protein	-	-	-	-	-	-	-	-	-	-	-	-	AAA_2,ClpB_D2-small
HKD1_k127_5891275_0	1267535.KB906767_gene3340	9.953e-210	659.0	COG1260@1|root,COG1260@2|Bacteria,3Y325@57723|Acidobacteria,2JIPN@204432|Acidobacteriia	204432|Acidobacteriia	I	Myo-inositol-1-phosphate synthase	-	-	5.5.1.4	ko:K01858	ko00521,ko00562,ko01100,ko01130,map00521,map00562,map01100,map01130	-	R07324	RC01804	ko00000,ko00001,ko01000	-	-	-	Inos-1-P_synth,NAD_binding_5
HKD1_k127_5891275_10	720554.Clocl_2100	2.314e-28	124.0	COG0584@1|root,COG0584@2|Bacteria,1V3W4@1239|Firmicutes,24AVJ@186801|Clostridia,3WIKJ@541000|Ruminococcaceae	186801|Clostridia	C	glycerophosphoryl diester phosphodiesterase	glpQ	-	3.1.4.46	ko:K01126	ko00564,map00564	-	R01030,R01470	RC00017,RC00425	ko00000,ko00001,ko01000	-	-	-	GDPD
HKD1_k127_5891275_11	269799.Gmet_2836	2.087e-14	83.0	COG3170@1|root,COG3170@2|Bacteria,1REZ7@1224|Proteobacteria,42RFW@68525|delta/epsilon subdivisions,2WS8K@28221|Deltaproteobacteria,43VBZ@69541|Desulfuromonadales	28221|Deltaproteobacteria	NU	Protein of unknown function (DUF3108)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3108
HKD1_k127_5891275_8	861299.J421_3339	1.395e-39	158.0	COG2020@1|root,COG2020@2|Bacteria,1ZU79@142182|Gemmatimonadetes	142182|Gemmatimonadetes	O	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PEMT
HKD1_k127_5891275_5	1121405.dsmv_0519	2.943e-52	198.0	COG0859@1|root,COG0859@2|Bacteria,1MYZA@1224|Proteobacteria,43AFG@68525|delta/epsilon subdivisions,2WKA9@28221|Deltaproteobacteria,2MI8V@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02841	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD1_k127_5891275_4	330214.NIDE3031	9.551e-66	238.0	COG0241@1|root,COG0859@1|root,COG0241@2|Bacteria,COG0859@2|Bacteria,3J0PZ@40117|Nitrospirae	40117|Nitrospirae	EM	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02843	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9,Hydrolase_like
HKD1_k127_5891275_9	751944.HALDL1_10980	1.527e-28	125.0	COG0451@1|root,arCOG01369@2157|Archaea,2Y7SY@28890|Euryarchaeota,23SBI@183963|Halobacteria	183963|Halobacteria	M	Polysaccharide biosynthesis protein	-	-	5.1.3.10	ko:K12454	ko00520,map00520	-	R04266	RC00528	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_5891275_3	1125863.JAFN01000001_gene1580	1.298e-73	259.0	COG1226@1|root,COG1226@2|Bacteria,1MU1R@1224|Proteobacteria,42MW6@68525|delta/epsilon subdivisions,2WIYU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Ion transport 2 domain protein	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2,TrkA_C,TrkA_N
HKD1_k127_5891275_13	1410628.JNKS01000033_gene949	3.234e-10	61.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,27ICS@186928|unclassified Lachnospiraceae	186801|Clostridia	J	DALR_2	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_6065601_0	1267535.KB906767_gene1129	2.818e-107	376.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_6129643_22	1379698.RBG1_1C00001G0856	3.174e-37	142.0	COG0437@1|root,COG0437@2|Bacteria,2NNV6@2323|unclassified Bacteria	2|Bacteria	C	4Fe-4S dicluster domain	-	-	-	ko:K00184	-	-	-	-	ko00000	5.A.3	-	-	Fer4_7
HKD1_k127_6129643_2	1379698.RBG1_1C00001G0857	3.561e-201	636.0	COG5557@1|root,COG5557@2|Bacteria,2NNNQ@2323|unclassified Bacteria	1379698.RBG1_1C00001G0857|-	C	Polysulphide reductase, NrfD	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6129643_9	1379698.RBG1_1C00001G0858	4.175e-101	345.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C
HKD1_k127_6129643_27	682795.AciX8_2857	6.512e-09	61.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y9GC@57723|Acidobacteria,2JKTW@204432|Acidobacteriia	204432|Acidobacteriia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_6129643_28	1267533.KB906733_gene3563	8.757e-09	61.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C
HKD1_k127_6129643_7	1122604.JONR01000025_gene4602	7.076e-112	385.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_6129643_23	666509.RCA23_c24890	1.652e-35	146.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_11,TPR_12,TPR_16,TPR_2,TPR_6,TPR_8
HKD1_k127_6129643_30	387092.NIS_0681	2.746e-07	53.0	COG1913@1|root,COG1913@2|Bacteria,1N38I@1224|Proteobacteria,42UMZ@68525|delta/epsilon subdivisions,2YRXM@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Matrixin	-	-	-	ko:K06974	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M54
HKD1_k127_6129643_32	1125971.ASJB01000055_gene6702	0.0008684	44.0	28H5N@1|root,2Z7I8@2|Bacteria,2IC8E@201174|Actinobacteria,4E9GN@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6129643_19	234267.Acid_1209	1.104e-52	194.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_6129643_8	1267535.KB906767_gene1129	3.859e-110	393.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_6129643_31	204669.Acid345_4390	7.628e-07	57.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_6129643_20	671143.DAMO_2826	3.462e-47	173.0	COG0640@1|root,COG0640@2|Bacteria,2NQ74@2323|unclassified Bacteria	2|Bacteria	K	helix_turn_helix, Arsenical Resistance Operon Repressor	arsR9	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_20,HTH_5
HKD1_k127_6129643_25	861299.J421_0909	4.082e-25	111.0	COG2940@1|root,COG2940@2|Bacteria,1ZTR3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD1_k127_6129643_13	671143.DAMO_2827	6.555e-79	267.0	COG3260@1|root,COG3260@2|Bacteria,2NRM4@2323|unclassified Bacteria	2|Bacteria	C	NADH ubiquinone oxidoreductase, 20 Kd subunit	hycG	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_6129643_3	671143.DAMO_2828	2.006e-192	621.0	COG0651@1|root,COG0651@2|Bacteria,2NR9Z@2323|unclassified Bacteria	2|Bacteria	CP	Proton-conducting membrane transporter	hyfB	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K12137,ko:K15828	-	-	-	-	ko00000,ko01000	-	-	iB21_1397.B21_02538,iECBD_1354.ECBD_1002,iECB_1328.ECB_02573,iECD_1391.ECD_02573,iECED1_1282.ECED1_3174,iECO111_1330.ECO111_3443,iECO26_1355.ECO26_3788,iECP_1309.ECP_2686,iEKO11_1354.EKO11_1252,iEcHS_1320.EcHS_A2859,iLF82_1304.LF82_1065,iNRG857_1313.NRG857_13330	Proton_antipo_M,Proton_antipo_N
HKD1_k127_6129643_10	671143.DAMO_2829	6.12e-98	330.0	COG0650@1|root,COG0650@2|Bacteria,2NRV1@2323|unclassified Bacteria	2|Bacteria	C	NADH dehydrogenase	hycD	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_6129643_21	671143.DAMO_2830	5.64e-43	165.0	COG4237@1|root,COG4237@2|Bacteria	2|Bacteria	C	Hydrogenase 4 membrane	hyfE	GO:0008150,GO:0040007	-	ko:K12140	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_6129643_6	671143.DAMO_2831	5.568e-113	381.0	COG0651@1|root,COG0651@2|Bacteria,2NS4P@2323|unclassified Bacteria	2|Bacteria	CP	Proton-conducting membrane transporter	hyfF	GO:0005575,GO:0005623,GO:0005886,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0016020,GO:0016021,GO:0031224,GO:0033554,GO:0044425,GO:0044464,GO:0050896,GO:0051716,GO:0071944	-	ko:K12141	-	-	-	-	ko00000,ko01000	-	-	iECIAI39_1322.ECIAI39_2625,iZ_1308.Z3746	Proton_antipo_M,Proton_antipo_N
HKD1_k127_6129643_4	671143.DAMO_2832	1.258e-163	532.0	COG3261@1|root,COG3262@1|root,COG3261@2|Bacteria,COG3262@2|Bacteria	2|Bacteria	C	NADH dehydrogenase (ubiquinone) activity	hycE	-	-	ko:K14089	-	-	-	-	ko00000	-	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_6129643_11	1121939.L861_01520	2.225e-94	310.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,1S25M@1236|Gammaproteobacteria,1XNFA@135619|Oceanospirillales	135619|Oceanospirillales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD1_k127_6129643_15	1353531.AZNX01000016_gene4310	9.195e-75	252.0	COG0346@1|root,COG0346@2|Bacteria,1RABI@1224|Proteobacteria,2TVEV@28211|Alphaproteobacteria,4BDYS@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase,Glyoxalase_4
HKD1_k127_6129643_0	386456.JQKN01000010_gene696	0.0	1241.0	COG0243@1|root,arCOG01492@2157|Archaea,2Y8AB@28890|Euryarchaeota	2157|Archaea	C	formate dehydrogenase, alpha subunit	-	-	1.17.1.9,1.20.2.1,1.20.9.1,1.7.5.1	ko:K00123,ko:K00370,ko:K08356	ko00630,ko00680,ko00910,ko01100,ko01120,ko01200,ko02020,map00630,map00680,map00910,map01100,map01120,map01200,map02020	M00529,M00530,M00804	R00519,R00798,R01106,R09497	RC02796,RC02812	ko00000,ko00001,ko00002,ko01000,ko02000	5.A.3.1,5.A.3.6	-	-	Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_6129643_17	1123234.AUKI01000016_gene3057	1.412e-61	224.0	COG1808@1|root,COG1808@2|Bacteria,4P1J9@976|Bacteroidetes	976|Bacteroidetes	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6129643_18	1166018.FAES_0546	1.899e-54	198.0	COG1335@1|root,COG1335@2|Bacteria,4NM6A@976|Bacteroidetes,47PA4@768503|Cytophagia	976|Bacteroidetes	Q	Isochorismatase family	-	-	-	-	-	-	-	-	-	-	-	-	Isochorismatase
HKD1_k127_6129643_14	795666.MW7_1939	7.792e-75	260.0	COG1633@1|root,COG1633@2|Bacteria,1RB01@1224|Proteobacteria,2VQJI@28216|Betaproteobacteria,1K7GH@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)	-	-	-	-	-	-	-	-	-	-	-	-	DUF892
HKD1_k127_6129643_24	1123368.AUIS01000005_gene414	2.467e-28	116.0	2E36Z@1|root,32Y6R@2|Bacteria,1NCM6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6129643_16	1267533.KB906735_gene4526	7.416e-73	256.0	COG1295@1|root,COG1295@2|Bacteria,3Y3RZ@57723|Acidobacteria,2JIYV@204432|Acidobacteriia	204432|Acidobacteriia	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_6129643_5	382464.ABSI01000011_gene2734	2.799e-115	393.0	COG0038@1|root,COG0038@2|Bacteria,46U35@74201|Verrucomicrobia,2IU1K@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	Voltage gated chloride channel	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Voltage_CLC
HKD1_k127_6129643_26	234267.Acid_2818	4.905e-11	70.0	2EPXQ@1|root,33HI8@2|Bacteria,3Y5ZD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6129643_1	1125863.JAFN01000001_gene1462	0.0	1095.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2WJ4J@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	copF	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase,YHS
HKD1_k127_6129643_12	485917.Phep_0675	4.383e-86	293.0	COG0726@1|root,COG0726@2|Bacteria,4NFJP@976|Bacteroidetes,1IQSF@117747|Sphingobacteriia	976|Bacteroidetes	G	polysaccharide deacetylase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	CelD_N,Glyco_hydro_9,Polysacc_deac_1
HKD1_k127_6160158_6	1218108.KB908292_gene1584	2.551e-18	89.0	2B14M@1|root,31TIF@2|Bacteria,4NRE0@976|Bacteroidetes,1I321@117743|Flavobacteriia	976|Bacteroidetes	S	Protein of unknown function (DUF2938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2938
HKD1_k127_6160158_4	40373.F991_02024	5.763e-27	117.0	2C73B@1|root,330Z7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
HKD1_k127_6160158_8	40373.F991_02024	2.674e-09	60.0	2C73B@1|root,330Z7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
HKD1_k127_6160158_0	794903.OPIT5_27075	1.666e-111	370.0	COG2801@1|root,COG2801@2|Bacteria,46V43@74201|Verrucomicrobia	74201|Verrucomicrobia	L	HTH-like domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve
HKD1_k127_6160158_7	78398.KS43_01740	1.047e-09	66.0	2FHXW@1|root,349QW@2|Bacteria,1P0Q3@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6160158_1	118173.KB235914_gene1912	3.672e-62	246.0	COG3209@1|root,COG3209@2|Bacteria,1G4PY@1117|Cyanobacteria,1H8YZ@1150|Oscillatoriales	1117|Cyanobacteria	M	RHS Repeat	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_6160158_2	1403819.BATR01000162_gene5427	9.195e-37	149.0	COG2197@1|root,COG2197@2|Bacteria,46V5Z@74201|Verrucomicrobia,2IUBG@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_6165362_6	452637.Oter_3034	1.64e-66	259.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	-	-	-	ko:K12287	-	-	-	-	ko00000,ko02044	-	-	-	Big_2,Calx-beta,Laminin_G_3,PA14,VPEP
HKD1_k127_6165362_8	861299.J421_0113	5.315e-62	244.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF5122,Laminin_G_3,VPEP
HKD1_k127_6165362_12	234267.Acid_5137	4.924e-53	215.0	COG4222@1|root,COG4222@2|Bacteria	2|Bacteria	S	Esterase-like activity of phytase	-	-	-	ko:K03929	-	-	-	-	ko00000,ko01000	-	CE10	-	CHRD,DUF839,HemolysinCabind,Phytase-like
HKD1_k127_6165362_1	234267.Acid_4413	1.672e-119	398.0	COG1134@1|root,COG1134@2|Bacteria,3Y72D@57723|Acidobacteria	57723|Acidobacteria	GM	Wzt C-terminal domain	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HKD1_k127_6165362_24	479432.Sros_4083	1.606e-10	73.0	COG0500@1|root,COG2226@2|Bacteria,2GJSF@201174|Actinobacteria,4EIGT@85012|Streptosporangiales	201174|Actinobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_6165362_2	555793.WSK_4263	2.413e-102	344.0	COG0438@1|root,COG0438@2|Bacteria,1NF7D@1224|Proteobacteria,2U52N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_1,Methyltransf_11
HKD1_k127_6165362_7	243233.MCA0997	6.674e-63	244.0	COG5427@1|root,COG5427@2|Bacteria	2|Bacteria	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_4	1121015.N789_13585	1.808e-91	311.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,1T27A@1236|Gammaproteobacteria,1XD5H@135614|Xanthomonadales	135614|Xanthomonadales	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_6165362_20	211165.AJLN01000116_gene2992	1.511e-21	111.0	COG0500@1|root,COG2226@2|Bacteria,1G96Z@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_18	211165.AJLN01000116_gene2992	1.844e-24	110.0	COG0500@1|root,COG2226@2|Bacteria,1G96Z@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_10	357808.RoseRS_0683	1.139e-54	221.0	COG0438@1|root,COG0438@2|Bacteria,2G6Z9@200795|Chloroflexi,3755I@32061|Chloroflexia	32061|Chloroflexia	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD1_k127_6165362_9	1122919.KB905549_gene2050	3.05e-59	236.0	COG0438@1|root,COG0438@2|Bacteria,1UASH@1239|Firmicutes,4HKSK@91061|Bacilli,26YUS@186822|Paenibacillaceae	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	DUF4214,Glyco_transf_4,Glycos_transf_1
HKD1_k127_6165362_22	1207055.C100_10150	1.153e-14	89.0	COG0500@1|root,COG2226@2|Bacteria,1PNZA@1224|Proteobacteria,2V1IN@28211|Alphaproteobacteria,2KBM8@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase small domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_27	1121468.AUBR01000025_gene2978	0.0003749	55.0	COG1361@1|root,COG1361@2|Bacteria,1VPQQ@1239|Firmicutes,24WHC@186801|Clostridia,42HPA@68295|Thermoanaerobacterales	186801|Clostridia	M	Conserved repeat domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_15	706587.Desti_1686	1.872e-40	165.0	COG2227@1|root,COG2227@2|Bacteria,1NN3B@1224|Proteobacteria	1224|Proteobacteria	J	Catalyzes carboxymethyl transfer from carboxy-S- adenosyl-L-methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5-carboxymethoxyuridine (cmo5U) at position 34 in tRNAs	-	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_23,Methyltransf_9
HKD1_k127_6165362_23	1047013.AQSP01000091_gene649	5.321e-11	74.0	COG2227@1|root,COG3408@1|root,COG2227@2|Bacteria,COG3408@2|Bacteria	2|Bacteria	G	Glycogen debranching enzyme	-	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Bac_rhamnosid6H,Bac_rhamnosid_C,CBM_6,Crystall,Glyco_hydro_64,Methyltransf_11,Methyltransf_23,RicinB_lectin_2,SLH
HKD1_k127_6165362_21	1121930.AQXG01000010_gene3074	9.145e-15	76.0	COG1943@1|root,COG1943@2|Bacteria,4NPPG@976|Bacteroidetes	976|Bacteroidetes	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_6165362_25	1469607.KK073768_gene1680	7.475e-05	49.0	COG1943@1|root,COG1943@2|Bacteria,1G73H@1117|Cyanobacteria,1HP8X@1161|Nostocales	1117|Cyanobacteria	L	PFAM Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_6165362_5	1174528.JH992898_gene3099	2.255e-91	335.0	COG4485@1|root,COG4485@2|Bacteria,1GGV1@1117|Cyanobacteria	1117|Cyanobacteria	S	Bacterial membrane protein, YfhO	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_14	234267.Acid_1421	1.645e-50	201.0	COG1807@1|root,COG1807@2|Bacteria,3Y2T0@57723|Acidobacteria	2|Bacteria	M	PFAM glycosyl transferase family 39	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HKD1_k127_6165362_19	211165.AJLN01000116_gene2992	1.52e-22	113.0	COG0500@1|root,COG2226@2|Bacteria,1G96Z@1117|Cyanobacteria	1117|Cyanobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6165362_0	402777.KB235904_gene4111	3.594e-125	433.0	COG0642@1|root,COG0784@1|root,COG2203@1|root,COG0784@2|Bacteria,COG2203@2|Bacteria,COG2205@2|Bacteria,1G09B@1117|Cyanobacteria,1HF9F@1150|Oscillatoriales	1117|Cyanobacteria	T	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_6165362_17	204669.Acid345_3711	5.397e-29	136.0	COG2202@1|root,COG3829@1|root,COG4566@1|root,COG2202@2|Bacteria,COG3829@2|Bacteria,COG4566@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K03776,ko:K14987	ko02020,ko02030,map02020,map02030	M00524	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	GAF,GAF_2,GerE,HTH_8,PAS,PAS_3,PAS_4,PAS_9,Response_reg,Sigma54_activat,SpoIIE
HKD1_k127_6165362_13	485913.Krac_9229	2.443e-51	190.0	COG2945@1|root,COG2945@2|Bacteria,2G9MQ@200795|Chloroflexi	200795|Chloroflexi	S	hydrolase of the alpha beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4
HKD1_k127_6165362_26	110319.CF8_3609	0.0001997	51.0	COG0394@1|root,COG0394@2|Bacteria,2IM0Q@201174|Actinobacteria,4DR9C@85009|Propionibacteriales	201174|Actinobacteria	T	Belongs to the low molecular weight phosphotyrosine protein phosphatase family	ptpA	GO:0003674,GO:0003824,GO:0004721,GO:0004725,GO:0005575,GO:0005576,GO:0005623,GO:0005886,GO:0006464,GO:0006470,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009405,GO:0009605,GO:0009607,GO:0009987,GO:0016020,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0019538,GO:0035335,GO:0035821,GO:0036211,GO:0042578,GO:0043170,GO:0043207,GO:0043412,GO:0044003,GO:0044046,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0050896,GO:0051701,GO:0051704,GO:0051707,GO:0051817,GO:0052031,GO:0052046,GO:0052047,GO:0052048,GO:0052083,GO:0052155,GO:0052173,GO:0052200,GO:0052212,GO:0052255,GO:0052278,GO:0052294,GO:0052552,GO:0052553,GO:0052561,GO:0052562,GO:0052564,GO:0052572,GO:0071704,GO:0071944,GO:0075136,GO:0140096,GO:1901564	3.1.3.48	ko:K01104	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_6165362_3	1382356.JQMP01000003_gene2445	3.831e-96	322.0	COG0136@1|root,COG0136@2|Bacteria,2G5T9@200795|Chloroflexi,27XNM@189775|Thermomicrobia	189775|Thermomicrobia	C	Belongs to the aspartate-semialdehyde dehydrogenase family	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_6176771_59	452637.Oter_4030	1.917e-20	102.0	COG0793@1|root,COG3577@1|root,COG0793@2|Bacteria,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	3.4.21.116	ko:K06399	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asp_protease_2,PDZ_2,Peptidase_S41
HKD1_k127_6176771_19	398720.MED217_01540	1.482e-157	512.0	COG4677@1|root,COG4677@2|Bacteria,4NITR@976|Bacteroidetes	976|Bacteroidetes	G	Pectinesterase	-	-	-	-	-	-	-	-	-	-	-	-	Mfa_like_1,Pectinesterase
HKD1_k127_6176771_41	1502852.FG94_04249	2.859e-42	161.0	COG2761@1|root,COG2761@2|Bacteria,1RIE0@1224|Proteobacteria,2W2Y2@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD1_k127_6176771_67	1173028.ANKO01000124_gene2870	1.533e-10	62.0	COG2026@1|root,COG2026@2|Bacteria,1GAIF@1117|Cyanobacteria	1117|Cyanobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_6176771_78	43989.cce_2898	0.0003676	45.0	COG2026@1|root,COG2026@2|Bacteria,1GKH3@1117|Cyanobacteria,3KKHM@43988|Cyanothece	1117|Cyanobacteria	DJ	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K06218	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD1_k127_6176771_68	592015.HMPREF1705_01629	1.753e-10	64.0	2CD07@1|root,2ZQEB@2|Bacteria	2|Bacteria	S	Antitoxin component of a toxin-antitoxin (TA) module	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD1_k127_6176771_1	335283.Neut_0196	7.581e-314	971.0	COG0422@1|root,COG0422@2|Bacteria,1MUVV@1224|Proteobacteria,2VHS3@28216|Betaproteobacteria,371QW@32003|Nitrosomonadales	28216|Betaproteobacteria	H	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction	thiC	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC-associated,ThiC_Rad_SAM
HKD1_k127_6176771_76	472759.Nhal_2487	5.122e-06	53.0	COG3809@1|root,COG3809@2|Bacteria,1NIWT@1224|Proteobacteria	1224|Proteobacteria	S	Transcription factor zinc-finger	-	-	-	ko:K09981	-	-	-	-	ko00000	-	-	-	zf-TFIIB
HKD1_k127_6176771_57	234267.Acid_7926	6.465e-23	103.0	COG1846@1|root,COG1846@2|Bacteria	2|Bacteria	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_6176771_52	234267.Acid_7925	1.343e-27	119.0	COG3832@1|root,COG3832@2|Bacteria,3Y94H@57723|Acidobacteria	57723|Acidobacteria	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_10	234267.Acid_3724	2.351e-203	647.0	COG2234@1|root,COG2234@2|Bacteria,3Y4CJ@57723|Acidobacteria	57723|Acidobacteria	S	PFAM peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD1_k127_6176771_77	1192034.CAP_3992	0.0001754	45.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria	1224|Proteobacteria	O	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD1_k127_6176771_31	401053.AciPR4_3406	1.087e-80	284.0	COG1231@1|root,COG1231@2|Bacteria,3Y895@57723|Acidobacteria,2JNAN@204432|Acidobacteriia	2|Bacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.25,1.4.3.4	ko:K00274,ko:K21639	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD1_k127_6176771_26	485913.Krac_0994	1.182e-93	317.0	COG2896@1|root,COG2896@2|Bacteria,2G5JT@200795|Chloroflexi	200795|Chloroflexi	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Mob_synth_C,Radical_SAM
HKD1_k127_6176771_21	861299.J421_0248	2.938e-132	464.0	COG0515@1|root,COG3899@1|root,COG0515@2|Bacteria,COG3899@2|Bacteria,1ZUXK@142182|Gemmatimonadetes	2|Bacteria	T	AAA ATPase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Trans_reg_C
HKD1_k127_6176771_39	1267533.KB906740_gene290	3.916e-49	197.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y3FE@57723|Acidobacteria	57723|Acidobacteria	KU	WD40 domain protein beta Propeller	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD1_k127_6176771_43	335543.Sfum_3325	6.683e-39	149.0	COG0438@1|root,COG0662@1|root,COG0438@2|Bacteria,COG0662@2|Bacteria,1MWSZ@1224|Proteobacteria,42NYZ@68525|delta/epsilon subdivisions,2WK9U@28221|Deltaproteobacteria,2MQ7Y@213462|Syntrophobacterales	28221|Deltaproteobacteria	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,MannoseP_isomer
HKD1_k127_6176771_49	634956.Geoth_1925	1.886e-30	123.0	COG4577@1|root,COG4577@2|Bacteria,1VA0E@1239|Firmicutes,4HM6R@91061|Bacilli,1WHNV@129337|Geobacillus	91061|Bacilli	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_6176771_13	485916.Dtox_3284	1.08e-180	575.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,260TZ@186807|Peptococcaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
HKD1_k127_6176771_60	1121472.AQWN01000002_gene2136	9.145e-20	96.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,262HN@186807|Peptococcaceae	186801|Clostridia	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
HKD1_k127_6176771_51	880073.Calab_3249	8.767e-28	115.0	COG4576@1|root,COG4576@2|Bacteria	2|Bacteria	CQ	ethanolamine utilization protein EutN carboxysome structural protein Ccml	eutN	-	-	ko:K04028	-	-	-	-	ko00000	-	-	-	EutN_CcmL
HKD1_k127_6176771_20	471223.GWCH70_0573	5.253e-135	450.0	COG1012@1|root,COG1012@2|Bacteria,1UHQT@1239|Firmicutes,4IS6J@91061|Bacilli,1WFP5@129337|Geobacillus	91061|Bacilli	C	Aldehyde	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD1_k127_6176771_46	1519464.HY22_04930	1.437e-37	145.0	COG4577@1|root,COG4577@2|Bacteria,1FFDI@1090|Chlorobi	1090|Chlorobi	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_6176771_66	401053.AciPR4_3056	4.362e-14	79.0	COG1426@1|root,COG1426@2|Bacteria,3Y5KP@57723|Acidobacteria,2JJWN@204432|Acidobacteriia	204432|Acidobacteriia	S	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_25
HKD1_k127_6176771_9	269799.Gmet_2293	1.083e-204	647.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,42M2M@68525|delta/epsilon subdivisions,2WJ5H@28221|Deltaproteobacteria,43TA3@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD1_k127_6176771_35	1242864.D187_009909	2.87e-57	207.0	COG0321@1|root,COG1051@1|root,COG0321@2|Bacteria,COG1051@2|Bacteria,1MU6A@1224|Proteobacteria,42RIC@68525|delta/epsilon subdivisions,2WPRF@28221|Deltaproteobacteria,2YVCE@29|Myxococcales	28221|Deltaproteobacteria	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,NUDIX
HKD1_k127_6176771_24	357808.RoseRS_0175	3.455e-101	340.0	COG1171@1|root,COG1171@2|Bacteria,2G69F@200795|Chloroflexi,376BW@32061|Chloroflexia	32061|Chloroflexia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6176771_63	317936.Nos7107_1718	4.005e-15	82.0	28UBM@1|root,2ZGH0@2|Bacteria	2|Bacteria	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HKD1_k127_6176771_48	1123508.JH636440_gene2560	5.391e-31	126.0	2BYEG@1|root,349F2@2|Bacteria,2J42U@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_30	1123508.JH636440_gene2559	4.288e-81	282.0	2EZN7@1|root,33ST8@2|Bacteria,2J2CB@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_23	1382359.JIAL01000001_gene2337	8.133e-105	356.0	COG2355@1|root,COG2355@2|Bacteria,3Y39A@57723|Acidobacteria,2JI1H@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_6176771_74	720554.Clocl_3337	2.953e-06	59.0	2EXKW@1|root,33QWT@2|Bacteria,1VQYT@1239|Firmicutes,24Y8H@186801|Clostridia,3WNZI@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_45	321327.CYA_2298	5.553e-38	152.0	COG2197@1|root,COG2197@2|Bacteria,1GHXP@1117|Cyanobacteria,1GZT1@1129|Synechococcus	1117|Cyanobacteria	T	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_6176771_47	1304875.JAFZ01000001_gene951	1.474e-31	145.0	COG3292@1|root,COG3829@1|root,COG4585@1|root,COG3292@2|Bacteria,COG3829@2|Bacteria,COG4585@2|Bacteria,3TAJV@508458|Synergistetes	508458|Synergistetes	T	Y_Y_Y domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HKD1_k127_6176771_27	1295642.H839_14129	1.295e-85	292.0	COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,4HC38@91061|Bacilli,1WFBY@129337|Geobacillus	91061|Bacilli	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
HKD1_k127_6176771_65	1123376.AUIU01000003_gene1639	7.466e-15	78.0	COG4974@1|root,COG4974@2|Bacteria,3J1FQ@40117|Nitrospirae	40117|Nitrospirae	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_6176771_53	237368.SCABRO_02261	2.472e-27	115.0	COG0582@1|root,COG0582@2|Bacteria,2J3PC@203682|Planctomycetes	203682|Planctomycetes	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_6176771_64	290317.Cpha266_1475	4.717e-15	78.0	2E8QS@1|root,3331S@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_7	344747.PM8797T_00899	9.99e-214	675.0	COG0702@1|root,COG0702@2|Bacteria,2IYQV@203682|Planctomycetes	203682|Planctomycetes	GM	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	DUF2867,NAD_binding_10
HKD1_k127_6176771_37	404589.Anae109_3186	1.983e-51	188.0	COG3040@1|root,COG3040@2|Bacteria,1RIHP@1224|Proteobacteria,42SSW@68525|delta/epsilon subdivisions,2X6M9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Lipocalin-like domain	-	-	-	ko:K03098	-	-	-	-	ko00000,ko04147	-	-	-	Lipocalin_2
HKD1_k127_6176771_40	234831.PSM_A1680	8.037e-43	164.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,1RSMY@1236|Gammaproteobacteria,2Q18Y@267888|Pseudoalteromonadaceae	1236|Gammaproteobacteria	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_6176771_38	1123242.JH636434_gene5321	5.263e-51	188.0	COG2335@1|root,COG2335@2|Bacteria,2IZDI@203682|Planctomycetes	203682|Planctomycetes	M	COG2335 Secreted and surface protein containing fasciclin-like repeats	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD1_k127_6176771_61	262724.TT_P0056	6.154e-16	88.0	COG5012@1|root,COG5012@2|Bacteria,1WI7R@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	PFAM MerR family regulatory protein	-	-	-	ko:K22491	-	-	-	-	ko00000,ko03000	-	-	-	B12-binding,B12-binding_2,MerR,MerR_1
HKD1_k127_6176771_55	948106.AWZT01000103_gene3740	1.132e-25	110.0	2DP8X@1|root,33127@2|Bacteria,1ND0W@1224|Proteobacteria,2W78Y@28216|Betaproteobacteria,1KE3N@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_54	1267535.KB906767_gene1960	4.863e-27	113.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg,TauD
HKD1_k127_6176771_33	1267535.KB906767_gene1959	1.291e-62	222.0	COG2197@1|root,COG2197@2|Bacteria,3Y669@57723|Acidobacteria	57723|Acidobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_6176771_6	1267535.KB906767_gene1958	8.596e-221	718.0	COG3292@1|root,COG4585@1|root,COG3292@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02480,ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,Reg_prop,Y_Y_Y
HKD1_k127_6176771_72	1541065.JRFE01000010_gene4328	3.262e-07	52.0	COG1848@1|root,COG1848@2|Bacteria,1G6FV@1117|Cyanobacteria,3VN8D@52604|Pleurocapsales	1117|Cyanobacteria	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_6176771_18	234267.Acid_4535	2.746e-158	533.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_6176771_32	1248916.ANFY01000003_gene787	1.005e-66	232.0	COG0346@1|root,COG0346@2|Bacteria,1RK3P@1224|Proteobacteria,2UANZ@28211|Alphaproteobacteria,2K5JM@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_6176771_15	204669.Acid345_1052	9.774e-173	572.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6176771_14	204669.Acid345_1052	2.206e-174	576.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6176771_25	1379698.RBG1_1C00001G0607	3.411e-98	343.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_6176771_29	861299.J421_5759	2.424e-81	290.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,1ZUKV@142182|Gemmatimonadetes	142182|Gemmatimonadetes	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_6176771_28	204669.Acid345_1052	2.983e-83	298.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6176771_16	204669.Acid345_1052	1.461e-170	565.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6176771_8	118166.JH976538_gene5043	5.797e-208	661.0	28H5N@1|root,2Z7I8@2|Bacteria,1GCEG@1117|Cyanobacteria,1HE1R@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_0	118166.JH976538_gene5042	0.0	1620.0	COG0845@1|root,COG0845@2|Bacteria,1GCFD@1117|Cyanobacteria,1HF90@1150|Oscillatoriales	1117|Cyanobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_2	118166.JH976538_gene5041	4.022e-307	969.0	COG0222@1|root,COG0845@1|root,COG0222@2|Bacteria,COG0845@2|Bacteria,1GBZT@1117|Cyanobacteria,1HEC7@1150|Oscillatoriales	1117|Cyanobacteria	J	ribosome binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_3	272134.KB731324_gene1544	7.266e-297	948.0	COG0419@1|root,COG0419@2|Bacteria	2|Bacteria	L	ATPase involved in DNA repair	-	-	2.1.1.80,3.1.1.61	ko:K13924	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	AAA_13,AAA_23,Kelch_1,Kelch_4,Peptidase_C14,Tubulin_2,WD40
HKD1_k127_6176771_69	67356.KL575599_gene9200	4.882e-10	72.0	2BB9F@1|root,324S6@2|Bacteria,2H9Q8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_70	43759.JNWK01000005_gene884	6.618e-09	68.0	2BB9F@1|root,324S6@2|Bacteria,2H9Q8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_22	272134.KB731324_gene1546	1.367e-117	387.0	2F6ZT@1|root,33ZFN@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_44	1286171.EAL2_808p00850	2.424e-38	148.0	COG3603@1|root,COG3603@2|Bacteria,1V9Y8@1239|Firmicutes,24JKN@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	ko:K09707	-	-	-	-	ko00000	-	-	-	ACT_7
HKD1_k127_6176771_73	637389.Acaty_c1047	4.007e-07	62.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,1RQSM@1236|Gammaproteobacteria,2NBUQ@225057|Acidithiobacillales	225057|Acidithiobacillales	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_6176771_75	868864.Dester_1446	3.779e-06	59.0	COG0457@1|root,COG0457@2|Bacteria	868864.Dester_1446|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_56	1267535.KB906767_gene4448	4.013e-23	114.0	COG2304@1|root,COG2304@2|Bacteria,3Y30G@57723|Acidobacteria,2JIK2@204432|Acidobacteriia	204432|Acidobacteriia	S	PFAM von Willebrand factor type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2,VWA_3
HKD1_k127_6176771_11	497964.CfE428DRAFT_5214	8.643e-203	643.0	COG2425@1|root,COG2425@2|Bacteria,46UN1@74201|Verrucomicrobia	74201|Verrucomicrobia	S	TROVE domain	-	-	-	-	-	-	-	-	-	-	-	-	TROVE
HKD1_k127_6176771_58	765698.Mesci_4506	6.928e-21	96.0	2DRK9@1|root,33C5C@2|Bacteria,1NH0X@1224|Proteobacteria,2VGSZ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_50	234267.Acid_3418	6.18e-29	127.0	COG1403@1|root,COG1403@2|Bacteria,3Y3PW@57723|Acidobacteria	57723|Acidobacteria	L	PFAM HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD1_k127_6176771_17	118168.MC7420_1072	4.207e-162	518.0	COG1690@1|root,COG1690@2|Bacteria,1G0YE@1117|Cyanobacteria,1H8KT@1150|Oscillatoriales	1117|Cyanobacteria	S	family UPF0027	rtcB	-	6.5.1.3	ko:K14415	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Intein_splicing,RtcB
HKD1_k127_6176771_42	1123279.ATUS01000001_gene1852	3.639e-40	156.0	29NNR@1|root,31FC3@2|Bacteria,1R39F@1224|Proteobacteria,1T656@1236|Gammaproteobacteria,1JA0H@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6176771_34	381666.H16_A0700	3.087e-62	220.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2VQ9M@28216|Betaproteobacteria,1KCEX@119060|Burkholderiaceae	28216|Betaproteobacteria	C	[2Fe-2S] binding domain	iorA	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_6176771_5	1354722.JQLS01000001_gene4844	5.451e-256	808.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,46RIA@74030|Roseovarius	28211|Alphaproteobacteria	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C2
HKD1_k127_6176771_62	640512.BC1003_4484	1.889e-15	87.0	COG0589@1|root,COG0589@2|Bacteria,1NZ7U@1224|Proteobacteria,2W3MC@28216|Betaproteobacteria,1K4K5@119060|Burkholderiaceae	28216|Betaproteobacteria	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6176771_12	1297742.A176_06066	4.467e-186	586.0	COG1063@1|root,COG1063@2|Bacteria,1MW6Y@1224|Proteobacteria,42RN7@68525|delta/epsilon subdivisions,2WNNX@28221|Deltaproteobacteria,2Z317@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	adh	-	1.1.1.14,1.2.1.46	ko:K00008,ko:K00148,ko:K18369	ko00040,ko00051,ko00625,ko00640,ko00680,ko01100,ko01120,ko01200,map00040,map00051,map00625,map00640,map00680,map01100,map01120,map01200	M00014	R00604,R00875,R01896,R10703	RC00085,RC00102,RC00188,RC00545	ko00000,ko00001,ko00002,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6176771_4	1122221.JHVI01000016_gene1611	1.384e-290	918.0	COG0474@1|root,COG0474@2|Bacteria,1WICW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	P	ATPase P-type (Transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.6,3.6.3.8	ko:K01535,ko:K01537	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.2,3.A.3.3	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_6176771_36	234267.Acid_0626	7.64e-52	207.0	COG1470@1|root,COG2373@1|root,COG2931@1|root,COG3391@1|root,COG4886@1|root,COG5492@1|root,COG1470@2|Bacteria,COG2373@2|Bacteria,COG2931@2|Bacteria,COG3391@2|Bacteria,COG4886@2|Bacteria,COG5492@2|Bacteria,3Y49I@57723|Acidobacteria	57723|Acidobacteria	N	Bacterial Ig-like domain (group 3)	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,VCBS
HKD1_k127_6194406_4	497964.CfE428DRAFT_1156	3.124e-97	321.0	COG1538@1|root,COG1538@2|Bacteria,46UF0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_6194406_2	1403819.BATR01000112_gene3806	9.13e-237	743.0	COG0659@1|root,COG0659@2|Bacteria	2|Bacteria	P	secondary active sulfate transmembrane transporter activity	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD1_k127_6194406_5	1396141.BATP01000001_gene5388	2.918e-38	147.0	COG1226@1|root,3171K@2|Bacteria,46WQS@74201|Verrucomicrobia	74201|Verrucomicrobia	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_6194406_6	247490.KSU1_C1448	1.5e-27	122.0	2CA7I@1|root,30E5G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6194406_3	497964.CfE428DRAFT_6197	8.651e-115	387.0	COG2911@1|root,COG2911@2|Bacteria	2|Bacteria	S	protein secretion	-	-	-	ko:K15125	ko05133,map05133	-	-	-	ko00000,ko00001,ko00536	-	-	-	Porin_2
HKD1_k127_6194406_0	497964.CfE428DRAFT_1137	8.121e-320	996.0	COG0282@1|root,COG4869@1|root,COG0282@2|Bacteria,COG4869@2|Bacteria,46SKB@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	-	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase,PTAC,cNMP_binding
HKD1_k127_6194406_1	864069.MicloDRAFT_00035630	1.324e-281	872.0	COG1760@1|root,COG1760@2|Bacteria,1MUZN@1224|Proteobacteria,2UQSP@28211|Alphaproteobacteria,1JZ52@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Serine dehydratase beta chain	-	-	-	-	-	-	-	-	-	-	-	-	SDH_alpha,SDH_beta
HKD1_k127_6194406_7	1123487.KB892838_gene3851	8.32e-22	98.0	COG1882@1|root,COG1882@2|Bacteria,1MWBF@1224|Proteobacteria,2VNB9@28216|Betaproteobacteria,2KX4G@206389|Rhodocyclales	206389|Rhodocyclales	C	Pyruvate formate lyase-like	-	-	2.3.1.54,4.1.99.11	ko:K00656,ko:K07540	ko00620,ko00623,ko00640,ko00650,ko01100,ko01120,ko01220,map00620,map00623,map00640,map00650,map01100,map01120,map01220	M00418	R00212,R05598,R06987	RC00004,RC01181,RC01433,RC01434,RC02742,RC02833	ko00000,ko00001,ko00002,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_6194995_14	497964.CfE428DRAFT_1207	2.344e-13	70.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_6194995_11	1123368.AUIS01000006_gene597	8.735e-23	102.0	COG0071@1|root,COG0071@2|Bacteria,1NPJI@1224|Proteobacteria,1SRY5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	O	Hsp20/alpha crystallin family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_6194995_0	105559.Nwat_1694	9.378e-272	860.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,1S0BH@1236|Gammaproteobacteria,1X076@135613|Chromatiales	135613|Chromatiales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_6194995_10	941449.dsx2_0702	7.505e-40	157.0	COG1102@1|root,COG1102@2|Bacteria	2|Bacteria	F	Psort location Cytoplasmic, score	mmyX	-	2.7.4.25,5.3.1.12	ko:K00945,ko:K01812,ko:K16139	ko00040,ko00240,ko01100,map00040,map00240,map01100	M00052,M00061,M00631	R00158,R00512,R01482,R01665,R01983	RC00002,RC00376	ko00000,ko00001,ko00002,ko01000,ko02000	2.A.2	-	-	AAA_28,Cytidylate_kin2,MFS_2
HKD1_k127_6194995_1	479434.Sthe_1950	1.745e-154	512.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2G5Q5@200795|Chloroflexi,27Y10@189775|Thermomicrobia	200795|Chloroflexi	EU	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_6194995_3	204669.Acid345_2278	1.181e-140	457.0	COG2021@1|root,COG2021@2|Bacteria,3Y2FF@57723|Acidobacteria,2JHN8@204432|Acidobacteriia	204432|Acidobacteriia	E	PFAM alpha beta hydrolase	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_6194995_6	1519464.HY22_00015	6.305e-69	241.0	COG0664@1|root,COG0664@2|Bacteria,1FF3S@1090|Chlorobi	1090|Chlorobi	T	Popeye protein conserved region	-	-	-	-	-	-	-	-	-	-	-	-	Popeye
HKD1_k127_6194995_8	485913.Krac_5622	3.007e-46	168.0	COG5207@1|root,COG5207@2|Bacteria	2|Bacteria	O	Pfam Zn-finger in ubiquitin-hydrolases and other protein	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N,zf-UBP
HKD1_k127_6194995_4	861299.J421_6340	3.328e-101	335.0	COG1028@1|root,COG1028@2|Bacteria,1ZTIT@142182|Gemmatimonadetes	142182|Gemmatimonadetes	IQ	KR domain	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_6194995_9	861299.J421_6341	6.934e-43	161.0	COG1917@1|root,COG1917@2|Bacteria,1ZTY8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_6194995_7	395019.Bmul_3530	1.228e-46	181.0	COG0627@1|root,COG0627@2|Bacteria,1N3VN@1224|Proteobacteria,2WGE4@28216|Betaproteobacteria,1K04T@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Esterase	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD1_k127_6194995_2	118163.Ple7327_0557	1.569e-149	494.0	COG3975@1|root,COG3975@2|Bacteria,1G0YP@1117|Cyanobacteria,3VHK8@52604|Pleurocapsales	1117|Cyanobacteria	S	protease with the C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Peptidase_M61
HKD1_k127_6194995_5	1123355.JHYO01000013_gene1144	1.761e-85	299.0	COG0477@1|root,COG2814@2|Bacteria,1MVSH@1224|Proteobacteria,2TUEW@28211|Alphaproteobacteria,36Y2U@31993|Methylocystaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	-	-	-	ko:K08151	-	M00668	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75	-	-	MFS_1,MFS_1_like,MFS_2,Sugar_tr
HKD1_k127_6195362_28	234267.Acid_5120	1.016e-18	86.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_6195362_17	240015.ACP_2944	7.177e-53	191.0	COG0102@1|root,COG0102@2|Bacteria,3Y4U5@57723|Acidobacteria,2JJGG@204432|Acidobacteriia	204432|Acidobacteriia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_6195362_19	97138.C820_00832	1.672e-48	176.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,36IRJ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_6195362_5	682795.AciX8_4594	6.63e-103	342.0	COG0052@1|root,COG0052@2|Bacteria,3Y3K2@57723|Acidobacteria,2JI0A@204432|Acidobacteriia	204432|Acidobacteriia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_6195362_12	767817.Desgi_1828	2.344e-81	276.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,260PI@186807|Peptococcaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD1_k127_6195362_9	871968.DESME_11335	5.872e-92	309.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,260FG@186807|Peptococcaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_6195362_14	234267.Acid_0903	7.048e-65	228.0	COG0233@1|root,COG0233@2|Bacteria,3Y4AP@57723|Acidobacteria	57723|Acidobacteria	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD1_k127_6195362_16	525904.Tter_0360	1.138e-61	237.0	COG5427@1|root,COG5427@2|Bacteria	2|Bacteria	M	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6195362_21	240016.ABIZ01000001_gene2631	2.782e-46	188.0	COG4745@1|root,COG4745@2|Bacteria,46T45@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_6195362_34	1408311.JNJM01000003_gene2960	3.583e-06	49.0	COG2929@1|root,COG2929@2|Bacteria,1TV58@1239|Firmicutes,259IF@186801|Clostridia,2PTNQ@265975|Oribacterium	186801|Clostridia	S	Ribonuclease toxin, BrnT, of type II toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	BrnT_toxin
HKD1_k127_6195362_30	1173020.Cha6605_2506	1.109e-12	71.0	2C6B2@1|root,335GA@2|Bacteria,1G9BT@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6195362_6	485913.Krac_2435	1.342e-98	332.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrB	-	1.3.7.9	ko:K04109	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_6195362_23	868595.Desca_1562	1.678e-31	131.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,260Y2@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
HKD1_k127_6195362_31	1123288.SOV_1c08750	1.183e-08	63.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,4H4YZ@909932|Negativicutes	909932|Negativicutes	CO	Periplasmic protein thiol disulfide oxidoreductase, DsbE subfamily	dsbE	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_6195362_20	234267.Acid_1082	1.211e-47	178.0	COG0424@1|root,COG0424@2|Bacteria,3Y4ZU@57723|Acidobacteria	57723|Acidobacteria	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD1_k127_6195362_35	483219.LILAB_28280	6.756e-06	54.0	COG5512@1|root,COG5512@2|Bacteria,1N6KK@1224|Proteobacteria,42TK4@68525|delta/epsilon subdivisions,2WSPG@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD1_k127_6195362_29	1462526.BN990_04102	1.261e-13	74.0	COG0721@1|root,COG0721@2|Bacteria,1VEK3@1239|Firmicutes,4HNNA@91061|Bacilli,4C5YC@84406|Virgibacillus	91061|Bacilli	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD1_k127_6195362_1	204669.Acid345_0501	3.193e-176	564.0	COG0154@1|root,COG0154@2|Bacteria,3Y2PE@57723|Acidobacteria,2JIE0@204432|Acidobacteriia	204432|Acidobacteriia	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_6195362_27	682795.AciX8_0692	2.392e-25	120.0	COG4775@1|root,COG4775@2|Bacteria,3Y7I1@57723|Acidobacteria	57723|Acidobacteria	M	PFAM Surface antigen variable number	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	POTRA
HKD1_k127_6195362_11	204669.Acid345_1010	2.111e-83	288.0	COG0429@1|root,COG0429@2|Bacteria,3Y3MP@57723|Acidobacteria,2JI5X@204432|Acidobacteriia	204432|Acidobacteriia	S	Serine aminopeptidase, S33	-	-	-	ko:K07019	-	-	-	-	ko00000	-	-	-	Abhydrolase_1
HKD1_k127_6195362_4	502025.Hoch_3702	8.625e-123	438.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,42MN9@68525|delta/epsilon subdivisions,2WJZF@28221|Deltaproteobacteria,2YU45@29|Myxococcales	28221|Deltaproteobacteria	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_6195362_22	29540.C481_11485	4.893e-32	134.0	COG1651@1|root,COG2116@1|root,arCOG02868@2157|Archaea,arCOG03454@2157|Archaea,2XW8R@28890|Euryarchaeota,23U3Q@183963|Halobacteria	183963|Halobacteria	OP	DSBA-like thioredoxin domain	-	-	-	ko:K21990	-	-	-	-	ko00000	1.A.16.4	-	-	Form_Nir_trans,Thioredoxin_4
HKD1_k127_6195362_0	1382306.JNIM01000001_gene1023	1.1e-302	948.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	hcrA	-	1.3.7.9	ko:K04108	ko00362,ko00627,ko01100,ko01120,ko01220,map00362,map00627,map01100,map01120,map01220	-	R05316	RC00490	ko00000,ko00001,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_6195362_15	485913.Krac_2433	8.96e-64	224.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi	200795|Chloroflexi	C	2Fe-2S -binding domain protein	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_6195362_8	1121430.JMLG01000002_gene1142	1.279e-93	316.0	COG0414@1|root,COG0414@2|Bacteria,1TP7A@1239|Firmicutes,248AN@186801|Clostridia,26011@186807|Peptococcaceae	186801|Clostridia	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD1_k127_6195362_7	204669.Acid345_4746	3.205e-95	320.0	COG0413@1|root,COG0413@2|Bacteria,3Y3GX@57723|Acidobacteria,2JI6Y@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD1_k127_6195362_13	1125863.JAFN01000001_gene1971	2.506e-71	252.0	COG0329@1|root,COG0329@2|Bacteria,1MXI1@1224|Proteobacteria	1224|Proteobacteria	EM	Belongs to the DapA family	yagE	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005975,GO:0006082,GO:0008150,GO:0008152,GO:0009056,GO:0009987,GO:0016052,GO:0016054,GO:0016829,GO:0016830,GO:0016832,GO:0019520,GO:0019752,GO:0032787,GO:0042802,GO:0043436,GO:0044237,GO:0044238,GO:0044248,GO:0044262,GO:0044275,GO:0044281,GO:0044282,GO:0046176,GO:0046395,GO:0047440,GO:0071704,GO:0072329,GO:1901575	4.1.2.28,4.3.3.7	ko:K01714,ko:K22397	ko00040,ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00040,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R01782,R10147	RC00307,RC00572,RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_6195362_10	204669.Acid345_2181	1.206e-86	309.0	COG4365@1|root,COG4365@2|Bacteria,3Y4D6@57723|Acidobacteria,2JKER@204432|Acidobacteriia	204432|Acidobacteriia	S	Belongs to the BshC family	bshC	-	-	ko:K22136	-	-	-	-	ko00000	-	-	-	BshC
HKD1_k127_6195362_2	401053.AciPR4_0620	5.063e-164	541.0	COG0323@1|root,COG0323@2|Bacteria,3Y2T3@57723|Acidobacteria,2JI29@204432|Acidobacteriia	204432|Acidobacteriia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_6195362_26	1232410.KI421412_gene25	1.401e-25	111.0	COG1729@1|root,COG1729@2|Bacteria,1N0AW@1224|Proteobacteria,42TGH@68525|delta/epsilon subdivisions,2WQ33@28221|Deltaproteobacteria,43VCJ@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Thioredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_6,Thioredoxin_2,Thioredoxin_7
HKD1_k127_6195362_24	861299.J421_2552	6.332e-31	130.0	COG0546@1|root,COG0546@2|Bacteria,1ZTK9@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_6195362_25	204669.Acid345_0154	6.85e-29	121.0	COG4770@1|root,COG4770@2|Bacteria,3Y5QJ@57723|Acidobacteria,2JN6E@204432|Acidobacteriia	204432|Acidobacteriia	I	Biotin-requiring enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HKD1_k127_6195362_3	644282.Deba_3254	2.574e-158	514.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,42M14@68525|delta/epsilon subdivisions,2WIN7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	I	Biotin carboxylase	pccA	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_6195362_32	401053.AciPR4_0142	1.907e-06	53.0	2EN0M@1|root,33FNU@2|Bacteria,3Y60X@57723|Acidobacteria,2JJZX@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6195362_18	234267.Acid_6711	7.71e-50	185.0	COG0558@1|root,COG0558@2|Bacteria	2|Bacteria	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA1	-	2.7.8.5	ko:K00995	ko00564,ko01100,map00564,map01100	-	R01801	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf,DUF4833
HKD1_k127_6220777_5	1038860.AXAP01000116_gene6195	6.79e-77	269.0	COG0265@1|root,COG0265@2|Bacteria,1R6VW@1224|Proteobacteria,2UNAP@28211|Alphaproteobacteria,3K1U9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6220777_2	1038860.AXAP01000116_gene6193	1.709e-140	460.0	COG1502@1|root,COG1502@2|Bacteria,1R3TR@1224|Proteobacteria,2TU5P@28211|Alphaproteobacteria,3K3J1@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	Phospholipase D. Active site motifs.	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD1_k127_6220777_0	706587.Desti_1032	0.0	1595.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K03296,ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD1_k127_6220777_3	706587.Desti_1031	4.291e-118	393.0	COG0845@1|root,COG0845@2|Bacteria,1MUFW@1224|Proteobacteria,42N4G@68525|delta/epsilon subdivisions,2WJ8A@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585,ko:K07799	ko01501,ko01503,ko02020,map01501,map01503,map02020	M00646,M00647,M00648,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1,8.A.1.6	-	-	HlyD_D23
HKD1_k127_6220777_1	1267533.KB906737_gene1696	6.208e-222	692.0	COG4941@1|root,COG4941@2|Bacteria,3Y2V5@57723|Acidobacteria,2JKS8@204432|Acidobacteriia	204432|Acidobacteriia	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6220777_6	1120949.KB903295_gene2240	1.603e-65	234.0	COG3570@1|root,COG3570@2|Bacteria,2GNSH@201174|Actinobacteria,4DFH1@85008|Micromonosporales	201174|Actinobacteria	V	aminoglycoside hydroxyurea antibiotic resistance kinase	-	-	2.7.1.72	ko:K04343	-	M00766	R02225	RC00002,RC00078	br01600,ko00000,ko00002,ko01000,ko01504	-	-	-	APH_6_hur
HKD1_k127_6220777_8	1397666.RS24_01174	2.917e-19	93.0	2F81H@1|root,340EZ@2|Bacteria,1N5WY@1224|Proteobacteria,2UEF2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6220777_4	1238182.C882_0401	1.521e-80	281.0	COG3616@1|root,COG3616@2|Bacteria,1N2SF@1224|Proteobacteria,2VFY5@28211|Alphaproteobacteria,2JRKP@204441|Rhodospirillales	204441|Rhodospirillales	E	Putative serine dehydratase domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N,D-ser_dehydrat
HKD1_k127_6220777_7	204669.Acid345_4384	2.974e-65	236.0	COG3547@1|root,COG3547@2|Bacteria,3Y5SI@57723|Acidobacteria,2JNJP@204432|Acidobacteriia	204432|Acidobacteriia	L	Transposase IS116/IS110/IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_6237578_0	986075.CathTA2_0799	3.247e-129	422.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,4H9SQ@91061|Bacilli	91061|Bacilli	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0044424,GO:0044464	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD1_k127_6256235_13	1205680.CAKO01000040_gene693	5.046e-30	123.0	COG2175@1|root,COG2175@2|Bacteria,1Q0C7@1224|Proteobacteria,2TRGF@28211|Alphaproteobacteria,2JV63@204441|Rhodospirillales	204441|Rhodospirillales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD1_k127_6256235_12	1121920.AUAU01000001_gene2234	1.607e-32	134.0	2EPXQ@1|root,33HI8@2|Bacteria,3Y5ZD@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6256235_14	1267533.KB906733_gene3183	8.206e-13	70.0	COG0702@1|root,COG0702@2|Bacteria	2|Bacteria	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10,NmrA
HKD1_k127_6256235_5	118168.MC7420_4357	1.405e-171	568.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7TU@1150|Oscillatoriales	1117|Cyanobacteria	T	COGs COG5001 signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GAF_2,GGDEF,PAS,PAS_3,PAS_9
HKD1_k127_6256235_0	1382359.JIAL01000001_gene1410	0.0	1011.0	COG3250@1|root,COG3250@2|Bacteria,3Y6CM@57723|Acidobacteria,2JKZF@204432|Acidobacteriia	204432|Acidobacteriia	G	PFAM Glycoside hydrolase, family 2, TIM barrel	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_6256235_2	595460.RRSWK_02025	1.183e-276	876.0	COG3250@1|root,COG3250@2|Bacteria	2|Bacteria	G	beta-galactosidase activity	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_6256235_9	1267535.KB906767_gene2182	1.451e-105	352.0	COG0657@1|root,COG0657@2|Bacteria,3Y2TC@57723|Acidobacteria,2JIM8@204432|Acidobacteriia	204432|Acidobacteriia	I	alpha/beta hydrolase fold	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD1_k127_6256235_11	1121898.Q766_03410	2.336e-51	185.0	COG3250@1|root,COG3250@2|Bacteria,4NEWN@976|Bacteroidetes,1HXYF@117743|Flavobacteriia,2NT5D@237|Flavobacterium	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_6256235_1	452637.Oter_1355	1.269e-287	900.0	COG3250@1|root,COG3250@2|Bacteria,46UWF@74201|Verrucomicrobia,3K7BB@414999|Opitutae	414999|Opitutae	G	Belongs to the glycosyl hydrolase 2 family	-	-	3.2.1.23	ko:K01190	ko00052,ko00511,ko00600,ko01100,map00052,map00511,map00600,map01100	-	R01105,R01678,R03355,R04783,R06114	RC00049,RC00452	ko00000,ko00001,ko01000	-	-	-	DUF4982,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_6256235_6	926569.ANT_26630	1.023e-156	500.0	COG0667@1|root,COG0667@2|Bacteria,2G5VT@200795|Chloroflexi	200795|Chloroflexi	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_6256235_10	452637.Oter_1356	9.723e-99	329.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	rha1	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_6256235_4	1123008.KB905693_gene1405	1.168e-188	608.0	COG3669@1|root,COG3669@2|Bacteria,4NEDX@976|Bacteroidetes,2FNFV@200643|Bacteroidia,22WIN@171551|Porphyromonadaceae	976|Bacteroidetes	G	F5 8 type C domain protein	-	-	3.2.1.51	ko:K01206	ko00511,map00511	-	-	-	ko00000,ko00001,ko01000,ko04147	-	GH29	-	Alpha_L_fucos,CHB_HEX_C_1,F5_F8_type_C,Fn3_assoc
HKD1_k127_6256235_8	452637.Oter_1366	2.681e-123	404.0	COG3507@1|root,COG3940@1|root,COG3507@2|Bacteria,COG3940@2|Bacteria	2|Bacteria	G	arabinan catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	AbfB,Glyco_hydro_43
HKD1_k127_6256235_7	401053.AciPR4_1572	1.617e-135	448.0	COG3119@1|root,COG3119@2|Bacteria,3Y32F@57723|Acidobacteria,2JIJB@204432|Acidobacteriia	204432|Acidobacteriia	P	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4976,Sulfatase
HKD1_k127_6256235_3	1449050.JNLE01000003_gene2301	6.107e-258	831.0	COG3250@1|root,COG3250@2|Bacteria,1TU92@1239|Firmicutes,248WD@186801|Clostridia,36FQK@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 2 family	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C,Glyco_hydro_2,Glyco_hydro_2_C,Glyco_hydro_2_N
HKD1_k127_627310_1	880072.Desac_2082	8.154e-48	184.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,42R2X@68525|delta/epsilon subdivisions,2WMU1@28221|Deltaproteobacteria,2MQBQ@213462|Syntrophobacterales	28221|Deltaproteobacteria	NU	PFAM type II secretion system	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD1_k127_627310_2	1218076.BAYB01000012_gene2399	8.83e-46	180.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2VJ80@28216|Betaproteobacteria,1K2UP@119060|Burkholderiaceae	28216|Betaproteobacteria	U	Type II secretion system	tadB1	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD1_k127_627310_0	443143.GM18_2435	4.566e-173	553.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,42NAK@68525|delta/epsilon subdivisions,2WIYX@28221|Deltaproteobacteria,43SA4@69541|Desulfuromonadales	28221|Deltaproteobacteria	U	PFAM type II secretion system protein E	-	-	-	ko:K02283,ko:K03609	-	-	-	-	ko00000,ko02035,ko02044,ko03036,ko04812	-	-	-	CbiA,FHA,T2SSE
HKD1_k127_627310_3	338966.Ppro_2701	1.671e-43	174.0	COG2197@1|root,COG4963@1|root,COG2197@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,42QEH@68525|delta/epsilon subdivisions,2WKVC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	U	Response regulator, receiver	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	AAA_31,CBP_BcsQ,ParA,Response_reg
HKD1_k127_627310_4	1114970.PSF113_4185	1.763e-14	79.0	COG4961@1|root,COG4961@2|Bacteria,1N5M7@1224|Proteobacteria,1TC3D@1236|Gammaproteobacteria,1YPYG@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD1_k127_6327007_37	278963.ATWD01000002_gene863	3.107e-17	93.0	2A9J8@1|root,30YRM@2|Bacteria,3Y4IZ@57723|Acidobacteria,2JJDB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327007_31	118173.KB235914_gene4028	3.318e-30	128.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria,1H9ZU@1150|Oscillatoriales	1117|Cyanobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_16,TPR_2,TPR_8,Trypsin_2
HKD1_k127_6327007_4	234267.Acid_3931	4.778e-277	883.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD1_k127_6327007_34	1267535.KB906767_gene3018	3.275e-23	102.0	COG0776@1|root,COG0776@2|Bacteria,3Y5E1@57723|Acidobacteria,2JJN0@204432|Acidobacteriia	204432|Acidobacteriia	L	Bacterial DNA-binding protein	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_6327007_25	1121468.AUBR01000001_gene469	9.715e-43	164.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,42GAD@68295|Thermoanaerobacterales	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_6327007_9	204669.Acid345_1469	3.021e-93	320.0	COG4972@1|root,COG4972@2|Bacteria,3Y804@57723|Acidobacteria	57723|Acidobacteria	NU	Type IV pilus assembly protein PilM;	-	-	-	ko:K02662	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilM_2
HKD1_k127_6327007_43	439235.Dalk_0479	1.647e-06	58.0	COG3167@1|root,COG3167@2|Bacteria,1MZZ4@1224|Proteobacteria,43B6P@68525|delta/epsilon subdivisions,2X6K9@28221|Deltaproteobacteria,2MPI6@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	PFAM Pilus assembly protein PilO	pilO	-	-	ko:K02664	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilO
HKD1_k127_6327007_17	1047013.AQSP01000124_gene2676	7.902e-65	246.0	COG4796@1|root,COG4796@2|Bacteria,2NPEQ@2323|unclassified Bacteria	2|Bacteria	U	Secretin and TonB N terminus short domain	pilQ	-	-	ko:K02666	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	AMIN,STN,Secretin,Secretin_N
HKD1_k127_6327007_38	215803.DB30_2172	1.501e-15	81.0	COG2018@1|root,COG2018@2|Bacteria,1NG1T@1224|Proteobacteria,42VP4@68525|delta/epsilon subdivisions,2WS9A@28221|Deltaproteobacteria,2YVP4@29|Myxococcales	28221|Deltaproteobacteria	S	Roadblock/LC7 domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327007_36	748247.AZKH_1389	3.072e-17	94.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2VUA6@28216|Betaproteobacteria,2KWNV@206389|Rhodocyclales	206389|Rhodocyclales	L	Nuclease (SNase domain protein)	-	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD1_k127_6327007_23	909663.KI867150_gene2187	1.789e-51	192.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,42MBJ@68525|delta/epsilon subdivisions,2WNWX@28221|Deltaproteobacteria,2MQKM@213462|Syntrophobacterales	28221|Deltaproteobacteria	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD1_k127_6327007_35	1267535.KB906767_gene1297	1.591e-21	106.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_6327007_27	247490.KSU1_C0427	4.464e-38	153.0	COG0842@1|root,COG0842@2|Bacteria	2|Bacteria	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_6327007_20	1151117.AJLF01000002_gene260	1.426e-61	224.0	COG1131@1|root,arCOG00194@2157|Archaea,2XTJV@28890|Euryarchaeota,243U5@183968|Thermococci	183968|Thermococci	V	Domain of unknown function (DUF4162)	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_6327007_10	1267534.KB906759_gene1648	3.368e-93	318.0	COG1173@1|root,COG1173@2|Bacteria,3Y45P@57723|Acidobacteria,2JIKH@204432|Acidobacteriia	204432|Acidobacteriia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_6327007_11	1267533.KB906737_gene1964	2.79e-91	311.0	COG0601@1|root,COG0601@2|Bacteria,3Y437@57723|Acidobacteria,2JHY6@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_6327007_18	234267.Acid_7345	1.593e-64	229.0	COG0500@1|root,COG2226@2|Bacteria,3Y44I@57723|Acidobacteria	57723|Acidobacteria	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2)	menG	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_6327007_39	1121013.P873_12090	1.235e-12	80.0	COG0612@1|root,COG0612@2|Bacteria,1MU6R@1224|Proteobacteria,1RN3E@1236|Gammaproteobacteria,1X8AF@135614|Xanthomonadales	135614|Xanthomonadales	S	Insulinase (Peptidase family M16)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_6327007_32	234267.Acid_4425	1.648e-27	119.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6327007_42	240015.ACP_3477	2.956e-09	70.0	COG0810@1|root,COG0810@2|Bacteria,3Y58J@57723|Acidobacteria,2JJPH@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD1_k127_6327007_8	204536.SULAZ_0302	3.289e-99	338.0	COG0436@1|root,COG0436@2|Bacteria,2G3VY@200783|Aquificae	200783|Aquificae	E	PFAM Aminotransferase class I and II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6327007_22	234267.Acid_7275	1.963e-56	201.0	COG0669@1|root,COG0669@2|Bacteria,3Y4B6@57723|Acidobacteria	57723|Acidobacteria	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_6327007_0	118173.KB235914_gene1173	0.0	1412.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1G0PS@1117|Cyanobacteria,1H8PE@1150|Oscillatoriales	1117|Cyanobacteria	E	Vitamin B12 dependent methionine synthase, activation domain	metH	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008172,GO:0008652,GO:0008705,GO:0009058,GO:0009066,GO:0009067,GO:0009086,GO:0009987,GO:0016053,GO:0016740,GO:0016741,GO:0019752,GO:0032259,GO:0042084,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind,S-methyl_trans
HKD1_k127_6327007_24	1278073.MYSTI_03333	1.39e-43	173.0	COG0204@1|root,COG0204@2|Bacteria,1PZS9@1224|Proteobacteria,434JR@68525|delta/epsilon subdivisions,2WYX1@28221|Deltaproteobacteria,2Z0U7@29|Myxococcales	28221|Deltaproteobacteria	I	Phosphate acyltransferases	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_6327007_21	502025.Hoch_2148	2.167e-61	223.0	COG1597@1|root,COG1597@2|Bacteria,1RCJT@1224|Proteobacteria,42W6W@68525|delta/epsilon subdivisions,2X6V3@28221|Deltaproteobacteria,2YUYD@29|Myxococcales	28221|Deltaproteobacteria	I	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD1_k127_6327007_28	697282.Mettu_3684	1.252e-37	149.0	2E3V1@1|root,32YSA@2|Bacteria,1N7HB@1224|Proteobacteria,1SF7K@1236|Gammaproteobacteria,1XGMP@135618|Methylococcales	135618|Methylococcales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327007_26	497964.CfE428DRAFT_4951	3.714e-38	148.0	COG5485@1|root,COG5485@2|Bacteria,46T9K@74201|Verrucomicrobia	74201|Verrucomicrobia	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD1_k127_6327007_12	404589.Anae109_1211	4.452e-87	300.0	COG0451@1|root,COG0451@2|Bacteria,1MW32@1224|Proteobacteria,42NJT@68525|delta/epsilon subdivisions,2WM7E@28221|Deltaproteobacteria,2YXN2@29|Myxococcales	28221|Deltaproteobacteria	GM	epimerase dehydratase	dfrA	-	1.1.1.219	ko:K00091	-	-	-	-	ko00000,ko01000	-	-	-	3Beta_HSD,Epimerase
HKD1_k127_6327007_1	1242864.D187_010275	0.0	1281.0	COG0204@1|root,COG1022@1|root,COG3320@1|root,COG0204@2|Bacteria,COG1022@2|Bacteria,COG3320@2|Bacteria,1MU4D@1224|Proteobacteria,42NHQ@68525|delta/epsilon subdivisions,2WJZ5@28221|Deltaproteobacteria,2YU6Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Male sterility protein	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding,AMP-binding_C,Acyltransferase,NAD_binding_4,PP-binding,Sterile
HKD1_k127_6327007_40	4577.GRMZM2G098212_P01	7.915e-12	72.0	COG0457@1|root,COG0666@1|root,KOG0504@2759|Eukaryota,KOG0548@2759|Eukaryota,37HF2@33090|Viridiplantae,3G8J9@35493|Streptophyta,3KNSD@4447|Liliopsida,3ICE1@38820|Poales	35493|Streptophyta	O	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank_2,Ank_3,Ank_4,Ank_5,DUF1685,TPR_17,TPR_8
HKD1_k127_6327007_5	404589.Anae109_1213	2.857e-225	709.0	COG3875@1|root,COG3875@2|Bacteria,1RFFK@1224|Proteobacteria,43957@68525|delta/epsilon subdivisions,2X4BI@28221|Deltaproteobacteria,2YYP6@29|Myxococcales	28221|Deltaproteobacteria	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_6327007_15	404589.Anae109_1214	1.329e-73	254.0	COG0560@1|root,COG0560@2|Bacteria,1RA1A@1224|Proteobacteria,42TQ7@68525|delta/epsilon subdivisions,2WS2Q@28221|Deltaproteobacteria,2Z36A@29|Myxococcales	28221|Deltaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_6327007_30	644282.Deba_0069	8.401e-31	132.0	COG0457@1|root,COG0457@2|Bacteria,1NNP4@1224|Proteobacteria,42VPE@68525|delta/epsilon subdivisions,2WRZ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TAtT
HKD1_k127_6327007_3	1267534.KB906754_gene3507	1.011e-288	915.0	COG1615@1|root,COG1615@2|Bacteria	2|Bacteria	S	Uncharacterised protein family (UPF0182)	-	GO:0005575,GO:0005576,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD1_k127_6327007_7	357808.RoseRS_1529	4.471e-100	346.0	COG0515@1|root,COG0515@2|Bacteria,2GACY@200795|Chloroflexi,375GK@32061|Chloroflexia	32061|Chloroflexia	KLT	SMART tyrosine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_6327007_6	234267.Acid_6499	1.803e-132	440.0	COG0006@1|root,COG0006@2|Bacteria,3Y36W@57723|Acidobacteria	57723|Acidobacteria	E	peptidase M24B X-Pro dipeptidase aminopeptidase domain protein	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD1_k127_6327007_16	926561.KB900618_gene362	4.415e-66	235.0	COG2503@1|root,COG2503@2|Bacteria,1UYMJ@1239|Firmicutes,24E99@186801|Clostridia	186801|Clostridia	M	5'-nucleotidase, lipoprotein e(P4) family	-	-	-	-	-	-	-	-	-	-	-	-	Acid_phosphat_B,LysM
HKD1_k127_6327007_29	479434.Sthe_1397	8.674e-37	144.0	COG3427@1|root,COG3427@2|Bacteria,2G6U6@200795|Chloroflexi,27YFP@189775|Thermomicrobia	189775|Thermomicrobia	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	ko:K09386	-	-	-	-	ko00000	-	-	-	COXG
HKD1_k127_6327007_13	485913.Krac_10571	7.198e-83	284.0	COG1319@1|root,COG1319@2|Bacteria,2G60Y@200795|Chloroflexi	200795|Chloroflexi	C	CO dehydrogenase flavoprotein domain protein	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_6327007_2	234267.Acid_2226	1.887e-300	942.0	COG1529@1|root,COG1529@2|Bacteria,3Y6BF@57723|Acidobacteria	57723|Acidobacteria	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.2.5.3	ko:K03520	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_6327007_14	479434.Sthe_1398	1.355e-75	256.0	COG2080@1|root,COG2080@2|Bacteria,2G6NT@200795|Chloroflexi,27XMB@189775|Thermomicrobia	189775|Thermomicrobia	C	[2Fe-2S] binding domain	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_6327007_19	1123277.KB893172_gene490	3.13e-63	225.0	2C5JH@1|root,32WG0@2|Bacteria,4P1NG@976|Bacteroidetes,47TH0@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_24	335543.Sfum_0973	1.166e-61	218.0	COG0110@1|root,COG0110@2|Bacteria,1PFB8@1224|Proteobacteria,439Z7@68525|delta/epsilon subdivisions,2X1Z1@28221|Deltaproteobacteria,2MSCA@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_6327147_22	1499967.BAYZ01000009_gene5270	3.773e-85	311.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,2NNNP@2323|unclassified Bacteria	2|Bacteria	D	CobQ CobB MinD ParA nucleotide binding domain	ywqD	-	2.7.10.1	ko:K08252,ko:K13661,ko:K16554,ko:K16692	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01001,ko02000	8.A.3.1	-	-	AAA_31,CbiA,GNVR,ParA,Wzz
HKD1_k127_6327147_26	370438.PTH_1080	1.697e-56	207.0	COG1091@1|root,COG1091@2|Bacteria,1TP71@1239|Firmicutes,247PG@186801|Clostridia,261FK@186807|Peptococcaceae	186801|Clostridia	M	Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4- hexulose to yield dTDP-L-rhamnose	-	-	1.1.1.133	ko:K00067	ko00521,ko00523,ko01130,map00521,map00523,map01130	M00793	R02777	RC00182	ko00000,ko00001,ko00002,ko01000	-	-	-	RmlD_sub_bind
HKD1_k127_6327147_11	1122918.KB907246_gene1441	1.486e-134	436.0	COG1088@1|root,COG1088@2|Bacteria,1TPWM@1239|Firmicutes,4HA3Y@91061|Bacilli,26RIV@186822|Paenibacillaceae	91061|Bacilli	M	Belongs to the NAD(P)-dependent epimerase dehydratase family. dTDP-glucose dehydratase subfamily	spsJ	-	4.2.1.46	ko:K01710	ko00521,ko00523,ko00525,ko01055,ko01130,map00521,map00523,map00525,map01055,map01130	M00793	R06513	RC00402	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_6327147_10	1232437.KL661959_gene3115	8.19e-135	437.0	COG1089@1|root,COG1089@2|Bacteria,1MUX0@1224|Proteobacteria,42KZY@68525|delta/epsilon subdivisions,2WJ4B@28221|Deltaproteobacteria,2MN0X@213118|Desulfobacterales	28221|Deltaproteobacteria	M	RmlD substrate binding domain	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_6327147_5	383372.Rcas_0785	5.721e-152	486.0	COG0673@1|root,COG0673@2|Bacteria,2G6PI@200795|Chloroflexi,376JZ@32061|Chloroflexia	32061|Chloroflexia	S	PFAM oxidoreductase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_6327147_17	926550.CLDAP_40370	6.605e-102	334.0	COG0110@1|root,COG0110@2|Bacteria,2G80Z@200795|Chloroflexi	200795|Chloroflexi	S	Hexapeptide repeat of succinyl-transferase	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep
HKD1_k127_6327147_2	383372.Rcas_0781	3.124e-172	548.0	COG0399@1|root,COG0399@2|Bacteria,2G7J4@200795|Chloroflexi,3772V@32061|Chloroflexia	32061|Chloroflexia	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6327147_12	1499967.BAYZ01000165_gene6642	4.299e-132	430.0	COG0381@1|root,COG0381@2|Bacteria,2NNVT@2323|unclassified Bacteria	2|Bacteria	M	UDP-N-acetylglucosamine 2-epimerase	wecB	-	5.1.3.14,5.1.3.23	ko:K01791,ko:K13019	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420,R09600	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HKD1_k127_6327147_23	1123326.JFBL01000004_gene2107	1.611e-64	231.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	ubiG	-	-	ko:K15257	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_23,Methyltransf_25
HKD1_k127_6327147_19	765952.PUV_00820	5.706e-95	328.0	COG0438@1|root,COG0438@2|Bacteria,2JGXA@204428|Chlamydiae	204428|Chlamydiae	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_29	880071.Fleli_0087	1.142e-52	200.0	COG1835@1|root,COG1835@2|Bacteria,4NNXT@976|Bacteroidetes,47SS3@768503|Cytophagia	976|Bacteroidetes	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD1_k127_6327147_13	1304874.JAFY01000002_gene1077	2.669e-120	394.0	COG0451@1|root,COG0451@2|Bacteria,3TAV7@508458|Synergistetes	508458|Synergistetes	M	PFAM NAD-dependent epimerase dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_6327147_9	1379270.AUXF01000002_gene1674	1.359e-135	444.0	COG0399@1|root,COG0399@2|Bacteria,1ZT81@142182|Gemmatimonadetes	2|Bacteria	M	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6327147_21	1304874.JAFY01000002_gene1081	9.33e-88	301.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD1_k127_6327147_3	1499967.BAYZ01000026_gene1631	9.377e-163	533.0	COG0367@1|root,COG0367@2|Bacteria,2NNKE@2323|unclassified Bacteria	2|Bacteria	E	PFAM asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_6327147_44	446471.Xcel_2551	4.42e-09	66.0	COG2227@1|root,COG2227@2|Bacteria,2I54M@201174|Actinobacteria,4F551@85017|Promicromonosporaceae	201174|Actinobacteria	H	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_6327147_20	497964.CfE428DRAFT_1683	5.352e-88	299.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_6327147_42	203119.Cthe_2397	1.036e-13	84.0	COG1807@1|root,COG1807@2|Bacteria,1V0V2@1239|Firmicutes,24BJF@186801|Clostridia,3WN2P@541000|Ruminococcaceae	186801|Clostridia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_6327147_1	335541.Swol_0712	7.355e-240	756.0	COG0367@1|root,COG0367@2|Bacteria,1TRPB@1239|Firmicutes,247YA@186801|Clostridia,42KHT@68298|Syntrophomonadaceae	186801|Clostridia	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_6327147_31	1123326.JFBL01000004_gene2100	8.962e-51	193.0	COG0223@1|root,COG0223@2|Bacteria,1MWH1@1224|Proteobacteria,42M1P@68525|delta/epsilon subdivisions,2YMPX@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	J	Formyl transferase	-	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD1_k127_6327147_32	1379270.AUXF01000002_gene1677	9.483e-51	189.0	2BFRM@1|root,329KE@2|Bacteria	2|Bacteria	-	-	wbmS	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_39	395492.Rleg2_4779	5.948e-27	123.0	COG0673@1|root,COG0673@2|Bacteria,1N0VK@1224|Proteobacteria,2TR13@28211|Alphaproteobacteria,4B81W@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_6327147_30	1033743.CAES01000089_gene2893	3.81e-52	199.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HDN8@91061|Bacilli,26VC7@186822|Paenibacillaceae	91061|Bacilli	M	DegT/DnrJ/EryC1/StrS aminotransferase family	pseC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6327147_33	755732.Fluta_0721	1.188e-41	163.0	COG0726@1|root,COG0726@2|Bacteria	2|Bacteria	G	polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD1_k127_6327147_40	1519464.HY22_07890	2.943e-19	100.0	COG2227@1|root,COG2227@2|Bacteria	2|Bacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD1_k127_6327147_28	1304888.ATWF01000002_gene378	2.417e-53	198.0	COG0223@1|root,COG0223@2|Bacteria	2|Bacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
HKD1_k127_6327147_27	1123326.JFBL01000004_gene2103	2.002e-55	202.0	COG0224@1|root,COG0224@2|Bacteria,1QUME@1224|Proteobacteria,42UU8@68525|delta/epsilon subdivisions,2YSCV@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	C	WbqC-like protein family	-	-	-	-	-	-	-	-	-	-	-	-	WbqC
HKD1_k127_6327147_18	234267.Acid_4640	1.852e-96	325.0	COG1682@1|root,COG1682@2|Bacteria,3Y7JV@57723|Acidobacteria	57723|Acidobacteria	GM	ABC-2 type transporter	-	-	-	ko:K09690	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC2_membrane
HKD1_k127_6327147_15	313606.M23134_02014	2.456e-109	367.0	COG1134@1|root,COG1134@2|Bacteria,4NEDM@976|Bacteroidetes,47JN7@768503|Cytophagia	976|Bacteroidetes	GM	ABC-type polysaccharide polyol phosphate transport system ATPase component	rfbB	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HKD1_k127_6327147_7	257310.BB0130	6.425e-147	476.0	COG0438@1|root,COG0438@2|Bacteria,1RKMI@1224|Proteobacteria,2WE4H@28216|Betaproteobacteria,3T8G8@506|Alcaligenaceae	28216|Betaproteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_16	1123326.JFBL01000004_gene2106	3.86e-103	351.0	COG0438@1|root,COG0438@2|Bacteria,1R56H@1224|Proteobacteria	1224|Proteobacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_0	1337936.IJ00_17795	0.0	1015.0	COG0367@1|root,COG0367@2|Bacteria,1G1WZ@1117|Cyanobacteria,1HK6A@1161|Nostocales	1117|Cyanobacteria	E	TIGRFAM asparagine synthase (glutamine-hydrolyzing)	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_6327147_36	557598.LHK_02794	2.505e-34	141.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	3.2.1.18	ko:K01186	ko00511,ko00600,ko04142,map00511,map00600,map04142	-	R04018	RC00028,RC00077	ko00000,ko00001,ko01000,ko02042	-	GH33	-	Lipase_GDSL_2
HKD1_k127_6327147_41	316055.RPE_1522	2.378e-17	91.0	COG0500@1|root,COG0500@2|Bacteria,1QYVI@1224|Proteobacteria	1224|Proteobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_6	765952.PUV_27280	4.309e-150	479.0	COG0451@1|root,COG0451@2|Bacteria,2JGMJ@204428|Chlamydiae	204428|Chlamydiae	GM	NAD(P)H-binding	-	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD1_k127_6327147_4	257310.BB0139	1.384e-152	490.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2VJDB@28216|Betaproteobacteria	28216|Betaproteobacteria	M	PFAM NAD-dependent epimerase dehydratase	-	-	4.1.1.35,4.2.1.46,5.1.3.2,5.1.3.7	ko:K01710,ko:K01784,ko:K02473,ko:K08678	ko00052,ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00052,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00362,M00632,M00793	R00291,R00418,R01384,R02984,R06513	RC00289,RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_6327147_37	1121406.JAEX01000002_gene999	6.873e-34	139.0	COG0500@1|root,COG4641@1|root,COG2226@2|Bacteria,COG4641@2|Bacteria,1R62R@1224|Proteobacteria,42YHA@68525|delta/epsilon subdivisions,2WU5S@28221|Deltaproteobacteria,2MC9R@213115|Desulfovibrionales	28221|Deltaproteobacteria	Q	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_2,Methyltransf_11
HKD1_k127_6327147_38	32057.KB217478_gene960	2.791e-29	126.0	COG4627@1|root,COG4627@2|Bacteria,1G5IW@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_6327147_45	1380391.JIAS01000014_gene1926	0.0003267	46.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,2JQWS@204441|Rhodospirillales	204441|Rhodospirillales	GM	GDP-mannose 4,6 dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_6327147_35	1150469.RSPPHO_00999	4.177e-38	147.0	COG0451@1|root,COG0451@2|Bacteria,1MXKV@1224|Proteobacteria,2TRM0@28211|Alphaproteobacteria,2JQWS@204441|Rhodospirillales	204441|Rhodospirillales	GM	GDP-mannose 4,6 dehydratase	-	-	4.1.1.35	ko:K08678	ko00520,ko01100,map00520,map01100	M00361	R01384	RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_6327147_14	111780.Sta7437_3173	5.7e-111	367.0	COG1216@1|root,COG1216@2|Bacteria,1G2TX@1117|Cyanobacteria,3VI9G@52604|Pleurocapsales	1117|Cyanobacteria	S	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_43	146922.JOFU01000067_gene6624	3.534e-09	68.0	COG2227@1|root,COG2227@2|Bacteria,2GW60@201174|Actinobacteria	201174|Actinobacteria	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_6327147_25	497965.Cyan7822_5349	1.652e-56	200.0	2EJXY@1|root,33DNK@2|Bacteria,1GDD5@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327147_8	589865.DaAHT2_1931	1.379e-142	468.0	COG0773@1|root,COG0773@2|Bacteria,1MUC5@1224|Proteobacteria,42NMY@68525|delta/epsilon subdivisions,2WJ8S@28221|Deltaproteobacteria,2MHS5@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Belongs to the MurCDEF family	mpl	-	6.3.2.45	ko:K02558	-	-	-	-	ko00000,ko01000	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_6327147_34	452637.Oter_1442	5.799e-41	153.0	COG0737@1|root,COG0737@2|Bacteria,46VVX@74201|Verrucomicrobia	74201|Verrucomicrobia	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HKD1_k127_6363478_1	448385.sce2804	3.481e-97	331.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_6363478_4	179408.Osc7112_4977	3.967e-10	63.0	2CCSR@1|root,32RWC@2|Bacteria,1GA04@1117|Cyanobacteria,1HDA0@1150|Oscillatoriales	1117|Cyanobacteria	S	PFAM S23 ribosomal protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_6363478_5	452637.Oter_1641	6.063e-09	62.0	2CCSR@1|root,32RWC@2|Bacteria,46WYJ@74201|Verrucomicrobia,3K9ZP@414999|Opitutae	414999|Opitutae	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_6363478_0	448385.sce2805	0.0	1328.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,42MF6@68525|delta/epsilon subdivisions,2WJ8D@28221|Deltaproteobacteria	28221|Deltaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD1_k127_6363478_6	1305737.JAFX01000001_gene2397	0.0003341	44.0	COG1943@1|root,COG1943@2|Bacteria,4NPPG@976|Bacteroidetes,47RSC@768503|Cytophagia	976|Bacteroidetes	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_6363478_3	665571.STHERM_c07040	3.153e-42	173.0	COG1488@1|root,COG1488@2|Bacteria,2J5IF@203691|Spirochaetes	203691|Spirochaetes	F	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP	pncB	-	6.3.4.21	ko:K00763	ko00760,ko01100,map00760,map01100	-	R01724	RC00033	ko00000,ko00001,ko01000	-	-	-	NAPRTase
HKD1_k127_6363478_2	644966.Tmar_1634	3.839e-60	213.0	COG1335@1|root,COG1335@2|Bacteria,1VI3P@1239|Firmicutes,24RP8@186801|Clostridia	186801|Clostridia	Q	PFAM Isochorismatase	-	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HKD1_k127_6392760_9	1121920.AUAU01000001_gene2168	3.651e-71	245.0	COG2519@1|root,COG2519@2|Bacteria,3Y5T2@57723|Acidobacteria	57723|Acidobacteria	J	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_31
HKD1_k127_6392760_3	886293.Sinac_2458	1.784e-136	443.0	COG0399@1|root,COG0399@2|Bacteria,2IXZR@203682|Planctomycetes	203682|Planctomycetes	E	DegT/DnrJ/EryC1/StrS aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6392760_4	1121033.AUCF01000008_gene5719	5.446e-119	390.0	COG0463@1|root,COG0463@2|Bacteria,1MXC1@1224|Proteobacteria,2TVY5@28211|Alphaproteobacteria,2JYTD@204441|Rhodospirillales	204441|Rhodospirillales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_6392760_16	1303518.CCALI_02808	1.27e-16	94.0	COG1807@1|root,COG1807@2|Bacteria	2|Bacteria	M	4-amino-4-deoxy-L-arabinose transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6392760_10	405948.SACE_7108	2.794e-68	244.0	COG2227@1|root,COG2227@2|Bacteria,2H217@201174|Actinobacteria	201174|Actinobacteria	H	3-demethylubiquinone-9 3-O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6392760_12	1501230.ET33_00540	3.486e-46	179.0	COG0615@1|root,COG0615@2|Bacteria,1VNXB@1239|Firmicutes	1239|Firmicutes	IM	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3
HKD1_k127_6392760_8	1278073.MYSTI_04368	6.712e-76	270.0	COG4122@1|root,COG4122@2|Bacteria,1R9D7@1224|Proteobacteria,42ZQ8@68525|delta/epsilon subdivisions,2WVSH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_24
HKD1_k127_6392760_1	880073.Calab_2669	3.143e-197	654.0	COG0438@1|root,COG1216@1|root,COG3551@1|root,COG0438@2|Bacteria,COG1216@2|Bacteria,COG3551@2|Bacteria,2NPQ4@2323|unclassified Bacteria	2|Bacteria	J	Glycosyltransferase like family 2	-	-	-	ko:K07011,ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2,Methyltransf_23
HKD1_k127_6392760_7	349741.Amuc_0395	3.174e-92	310.0	COG0689@1|root,COG0689@2|Bacteria,46U55@74201|Verrucomicrobia,2ITNM@203494|Verrucomicrobiae	203494|Verrucomicrobiae	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_6392760_2	497964.CfE428DRAFT_2886	2.552e-168	533.0	COG1089@1|root,COG1089@2|Bacteria,46SH0@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose	gmd	-	4.2.1.47	ko:K01711	ko00051,ko00520,ko01100,map00051,map00520,map01100	-	R00888	RC00402	ko00000,ko00001,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_6392760_11	497964.CfE428DRAFT_3536	1.621e-57	207.0	COG1376@1|root,COG1376@2|Bacteria,46VIF@74201|Verrucomicrobia	2|Bacteria	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_6392760_6	497964.CfE428DRAFT_3888	5.389e-95	319.0	COG0084@1|root,COG0084@2|Bacteria,46SKF@74201|Verrucomicrobia	74201|Verrucomicrobia	L	TatD related DNase	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_6392760_15	748280.NH8B_0901	1.079e-35	138.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2VRJ0@28216|Betaproteobacteria,2KT22@206351|Neisseriales	206351|Neisseriales	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD1_k127_6392760_19	1894.JOER01000017_gene4849	6.67e-12	66.0	COG3865@1|root,COG3865@2|Bacteria,2IIAX@201174|Actinobacteria	201174|Actinobacteria	S	3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD1_k127_6392760_0	330214.NIDE3482	8.15e-222	692.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR
HKD1_k127_6392760_13	1267535.KB906767_gene3397	8.316e-39	151.0	COG1977@1|root,COG1977@2|Bacteria,3Y5J3@57723|Acidobacteria,2JJVU@204432|Acidobacteriia	204432|Acidobacteriia	H	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6392760_5	631362.Thi970DRAFT_02437	1.73e-114	382.0	COG0387@1|root,COG0387@2|Bacteria,1MWD8@1224|Proteobacteria,1RME3@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	Calcium Proton	chaA	GO:0003674,GO:0005215,GO:0005451,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006813,GO:0006814,GO:0008150,GO:0008324,GO:0009987,GO:0015075,GO:0015077,GO:0015078,GO:0015079,GO:0015081,GO:0015291,GO:0015297,GO:0015298,GO:0015299,GO:0015318,GO:0015385,GO:0015386,GO:0015491,GO:0015672,GO:0016020,GO:0016021,GO:0022804,GO:0022821,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0035725,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0071804,GO:0071805,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:0099516,GO:1902600	-	ko:K07300	-	-	-	-	ko00000,ko02000	2.A.19	-	iB21_1397.B21_01204,iEC55989_1330.EC55989_1314,iECBD_1354.ECBD_2403,iECB_1328.ECB_01194,iECD_1391.ECD_01194,iECIAI1_1343.ECIAI1_1238,iECO103_1326.ECO103_1321,iECO111_1330.ECO111_1548,iECO26_1355.ECO26_1732,iECSE_1348.ECSE_1269,iECW_1372.ECW_m1308,iETEC_1333.ETEC_1322,iEcE24377_1341.EcE24377A_1366,iEcHS_1320.EcHS_A1324,iEcolC_1368.EcolC_2407,iSSON_1240.SSON_1961,iSbBS512_1146.SbBS512_E1383,iUMNK88_1353.UMNK88_1535,iWFL_1372.ECW_m1308	Na_Ca_ex
HKD1_k127_6392760_14	1385935.N836_29710	4.95e-36	142.0	COG0454@1|root,COG0456@2|Bacteria,1G646@1117|Cyanobacteria,1HC70@1150|Oscillatoriales	1117|Cyanobacteria	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_6392760_20	498761.HM1_3125	3.321e-09	59.0	2DSV3@1|root,33HII@2|Bacteria,1VQ64@1239|Firmicutes,24VWA@186801|Clostridia	186801|Clostridia	S	ORF located using Blastx	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6392760_17	1430440.MGMSRv2_1983	2.65e-16	83.0	2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6392760_21	1430440.MGMSRv2_1983	2.535e-08	55.0	2DNPH@1|root,32YF1@2|Bacteria,1NARM@1224|Proteobacteria,2UJNP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6392760_22	566461.SSFG_03801	2.863e-08	58.0	2B7FZ@1|root,320JU@2|Bacteria,2IQBZ@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6395855_5	319003.Bra1253DRAFT_06728	7.142e-47	170.0	COG3039@1|root,COG3039@2|Bacteria,1MVTU@1224|Proteobacteria,2TVIR@28211|Alphaproteobacteria,3JT6Q@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	hmm pf01609	-	-	-	ko:K07481	-	-	-	-	ko00000	-	-	-	DUF772
HKD1_k127_6395855_4	78245.Xaut_4877	4.026e-52	192.0	COG3047@1|root,COG3047@2|Bacteria,1N082@1224|Proteobacteria,2UDHR@28211|Alphaproteobacteria,3F2AK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	OprF membrane domain	-	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
HKD1_k127_6395855_3	1283300.ATXB01000002_gene3083	7.381e-82	282.0	COG2230@1|root,COG2230@2|Bacteria,1QUR4@1224|Proteobacteria,1RP3C@1236|Gammaproteobacteria,1XF6I@135618|Methylococcales	135618|Methylococcales	M	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_6395855_0	317936.Nos7107_1366	9.308e-265	880.0	COG0515@1|root,COG0642@1|root,COG2114@1|root,COG3899@1|root,COG0515@2|Bacteria,COG2114@2|Bacteria,COG2205@2|Bacteria,COG3899@2|Bacteria	2|Bacteria	T	PFAM Protein kinase domain	-	-	4.6.1.1	ko:K01768,ko:K07216	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_16,GAF,GGDEF,Guanylate_cyc,HATPase_c,HisKA,PAS_4,PAS_9,Pkinase,Response_reg
HKD1_k127_6395855_2	1267535.KB906767_gene3815	1.148e-153	503.0	COG1233@1|root,COG3349@1|root,COG1233@2|Bacteria,COG3349@2|Bacteria,3Y6NV@57723|Acidobacteria	57723|Acidobacteria	Q	Flavin containing amine oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase
HKD1_k127_6395855_6	318996.AXAZ01000018_gene1102	2.838e-39	149.0	COG4974@1|root,COG4974@2|Bacteria,1R6F9@1224|Proteobacteria,2U61F@28211|Alphaproteobacteria,3K2YB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD1_k127_6395855_1	1380355.JNIJ01000128_gene810	3.482e-183	577.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,3JUDN@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_6412687_7	247490.KSU1_B0365	9.847e-135	445.0	COG2204@1|root,COG2204@2|Bacteria,2IXIQ@203682|Planctomycetes	203682|Planctomycetes	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K07714	ko02020,map02020	M00500	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6412687_19	671143.DAMO_2141	4.107e-72	250.0	COG4122@1|root,COG4122@2|Bacteria,2NPV6@2323|unclassified Bacteria	2|Bacteria	S	Methyltransferase domain	yrrM	-	2.1.1.104	ko:K00588	ko00360,ko00940,ko00941,ko00945,ko01100,ko01110,map00360,map00940,map00941,map00945,map01100,map01110	M00039,M00350	R01942,R06578	RC00003,RC00392	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_3
HKD1_k127_6412687_33	1131269.AQVV01000001_gene1325	1.981e-39	154.0	COG0009@1|root,COG0009@2|Bacteria	2|Bacteria	J	L-threonylcarbamoyladenylate synthase	prmC	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD1_k127_6412687_26	204669.Acid345_1988	2.084e-51	202.0	COG0747@1|root,COG0747@2|Bacteria,3Y44K@57723|Acidobacteria,2JHM9@204432|Acidobacteriia	204432|Acidobacteriia	E	extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_6412687_21	1382359.JIAL01000001_gene190	1.966e-65	238.0	COG1472@1|root,COG1472@2|Bacteria,3Y32Y@57723|Acidobacteria,2JIFE@204432|Acidobacteriia	204432|Acidobacteriia	G	Glycosyl hydrolase family 3 N terminal domain	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD1_k127_6412687_28	330214.NIDE3388	3.497e-48	186.0	COG1208@1|root,COG1208@2|Bacteria,3J0QW@40117|Nitrospirae	40117|Nitrospirae	JM	Nucleotidyl transferase	-	-	2.7.7.13	ko:K00966	ko00051,ko00520,ko01100,ko01110,map00051,map00520,map01100,map01110	M00114,M00361,M00362	R00885	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_6412687_38	319225.Plut_2006	7.787e-36	150.0	COG3178@1|root,COG3178@2|Bacteria,1FEBN@1090|Chlorobi	1090|Chlorobi	S	PFAM aminoglycoside phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD1_k127_6412687_3	1191523.MROS_0139	1.698e-186	591.0	COG0017@1|root,COG0017@2|Bacteria	2|Bacteria	J	Asparaginyl-tRNA synthetase	asnS	GO:0003674,GO:0003824,GO:0004812,GO:0004816,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006421,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016875,GO:0019538,GO:0019752,GO:0034641,GO:0034645,GO:0034660,GO:0043038,GO:0043039,GO:0043043,GO:0043170,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564,GO:1901566,GO:1901576	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_6412687_34	348780.NP_0956A	5.251e-39	154.0	arCOG01781@1|root,arCOG01781@2157|Archaea,2XSY0@28890|Euryarchaeota,23RWZ@183963|Halobacteria	183963|Halobacteria	Q	COG0500 SAM-dependent methyltransferases	scm	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_6412687_40	945713.IALB_2664	3.572e-31	130.0	COG1611@1|root,COG1611@2|Bacteria	2|Bacteria	S	cytokinin biosynthetic process	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD1_k127_6412687_51	1267005.KB911256_gene2127	1.217e-18	96.0	COG2304@1|root,COG4249@1|root,COG2304@2|Bacteria,COG4249@2|Bacteria,1MXFD@1224|Proteobacteria,2TRW5@28211|Alphaproteobacteria,3N8R3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HKD1_k127_6412687_15	234267.Acid_2800	3.61e-94	320.0	COG0010@1|root,COG0010@2|Bacteria,3Y46E@57723|Acidobacteria	57723|Acidobacteria	E	Arginase family	-	-	3.5.3.1	ko:K01476	ko00220,ko00330,ko01100,ko01110,ko01130,ko01230,ko05146,map00220,map00330,map01100,map01110,map01130,map01230,map05146	M00029,M00134	R00551	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_6412687_10	1120973.AQXL01000126_gene2967	3.139e-116	385.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,4H9KB@91061|Bacilli,2791K@186823|Alicyclobacillaceae	91061|Bacilli	M	D-ala D-ala ligase N-terminus	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_6412687_39	204669.Acid345_0705	2e-33	141.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria,2JI8N@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_6412687_12	118168.MC7420_528	3.261e-110	366.0	COG2006@1|root,COG2006@2|Bacteria,1G0X0@1117|Cyanobacteria,1HF8Q@1150|Oscillatoriales	1117|Cyanobacteria	S	Domain of unknown function (DUF362)	-	-	-	-	-	-	-	-	-	-	-	-	DUF362
HKD1_k127_6412687_32	240016.ABIZ01000001_gene988	1.58e-39	150.0	COG1943@1|root,COG1943@2|Bacteria,46VP6@74201|Verrucomicrobia,2IVSQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_6412687_18	1122176.KB903532_gene2606	6.313e-82	284.0	COG1559@1|root,COG1559@2|Bacteria,4NG17@976|Bacteroidetes	976|Bacteroidetes	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD1_k127_6412687_48	357808.RoseRS_3225	3.328e-21	101.0	COG0816@1|root,COG0816@2|Bacteria,2G74F@200795|Chloroflexi,375V0@32061|Chloroflexia	32061|Chloroflexia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	GO:0000966,GO:0000967,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0022613,GO:0034470,GO:0034471,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD1_k127_6412687_24	926566.Terro_3785	1.001e-60	226.0	COG0793@1|root,COG0793@2|Bacteria,3Y3A7@57723|Acidobacteria,2JHJK@204432|Acidobacteriia	204432|Acidobacteriia	M	tail specific protease	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_6412687_9	269799.Gmet_3488	2.476e-116	387.0	2DBVK@1|root,2ZBBH@2|Bacteria,1PWZS@1224|Proteobacteria,432W2@68525|delta/epsilon subdivisions,2WXWI@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD1_k127_6412687_58	1121015.N789_08450	0.00013	51.0	2AQTF@1|root,31G1I@2|Bacteria,1QDTY@1224|Proteobacteria,1T9Z0@1236|Gammaproteobacteria,1X8GI@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412687_41	1242864.D187_006841	4.436e-31	131.0	2DI9M@1|root,302FW@2|Bacteria,1PVCY@1224|Proteobacteria,433WW@68525|delta/epsilon subdivisions,2X8YG@28221|Deltaproteobacteria,2YXHF@29|Myxococcales	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412687_23	1185876.BN8_05038	9.165e-61	215.0	2AYX9@1|root,31R2Z@2|Bacteria,4NNS4@976|Bacteroidetes,47RDY@768503|Cytophagia	976|Bacteroidetes	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_6412687_5	1267535.KB906767_gene1411	3.282e-181	582.0	COG1506@1|root,COG1506@2|Bacteria,3Y357@57723|Acidobacteria,2JIKY@204432|Acidobacteriia	204432|Acidobacteriia	E	Tannase and feruloyl esterase	-	-	-	-	-	-	-	-	-	-	-	-	Tannase
HKD1_k127_6412687_43	861299.J421_0551	4.455e-28	116.0	2DNQD@1|root,32YJR@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF3303)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3303
HKD1_k127_6412687_22	1267533.KB906740_gene263	1.075e-61	215.0	COG1917@1|root,COG1917@2|Bacteria,3Y94I@57723|Acidobacteria,2JNYP@204432|Acidobacteriia	204432|Acidobacteriia	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412687_49	1031711.RSPO_c00388	4.909e-19	98.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2VSHI@28216|Betaproteobacteria,1K79N@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Domain of unknown function (DUF4437)	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_1,Cupin_2,DUF4437
HKD1_k127_6412687_11	653045.Strvi_7203	8.479e-115	380.0	COG0205@1|root,COG0205@2|Bacteria,2GK6W@201174|Actinobacteria	201174|Actinobacteria	G	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfp	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_6412687_47	877414.ATWA01000007_gene198	3.367e-22	106.0	COG1214@1|root,COG1214@2|Bacteria,1V4YX@1239|Firmicutes,24A0P@186801|Clostridia,268G4@186813|unclassified Clostridiales	186801|Clostridia	O	Glycoprotease family	yeaZ	-	-	ko:K14742	-	-	-	-	ko00000,ko03016	-	-	-	Acetyltransf_1,Peptidase_M22
HKD1_k127_6412687_44	671143.DAMO_1552	4.553e-26	114.0	COG0454@1|root,COG0456@2|Bacteria,2NPTV@2323|unclassified Bacteria	2|Bacteria	K	This enzyme acetylates the N-terminal alanine of ribosomal protein S18	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_6412687_54	234267.Acid_0472	2.913e-09	62.0	2ETRB@1|root,33M8W@2|Bacteria,3Y5ZS@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF465)	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HKD1_k127_6412687_29	944564.HMPREF9200_0262	6.42e-48	179.0	COG0688@1|root,COG0688@2|Bacteria,1V3FQ@1239|Firmicutes,4H45T@909932|Negativicutes	909932|Negativicutes	I	Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD1_k127_6412687_30	204669.Acid345_2359	7.87e-46	180.0	COG1183@1|root,COG1183@2|Bacteria,3Y3I7@57723|Acidobacteria,2JIEG@204432|Acidobacteriia	204432|Acidobacteriia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_6412687_46	1220534.B655_2185	2.136e-22	110.0	COG1520@1|root,arCOG02492@2157|Archaea,2Y7Q0@28890|Euryarchaeota,23PZ1@183925|Methanobacteria	183925|Methanobacteria	S	PQQ-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_3
HKD1_k127_6412687_1	1123325.JHUV01000013_gene1626	3.577e-207	659.0	COG0518@1|root,COG0519@1|root,COG0518@2|Bacteria,COG0519@2|Bacteria,2G3NT@200783|Aquificae	200783|Aquificae	F	Catalyzes the synthesis of GMP from XMP	guaA	GO:0003674,GO:0003824,GO:0003921,GO:0003922,GO:0006139,GO:0006163,GO:0006164,GO:0006177,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009163,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016884,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046037,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD1_k127_6412687_0	243231.GSU1401	7.983e-306	976.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,42MGP@68525|delta/epsilon subdivisions,2WIZ2@28221|Deltaproteobacteria,43SUG@69541|Desulfuromonadales	28221|Deltaproteobacteria	L	TIGRFAM DNA polymerase III, alpha subunit	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_6412687_14	1340493.JNIF01000003_gene3064	2.812e-103	343.0	COG0825@1|root,COG0825@2|Bacteria,3Y34D@57723|Acidobacteria	57723|Acidobacteria	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD1_k127_6412687_35	614083.AWQR01000009_gene632	9.324e-38	146.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2VR2Z@28216|Betaproteobacteria,4ADQ7@80864|Comamonadaceae	28216|Betaproteobacteria	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	ssb	GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006298,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008047,GO:0008150,GO:0008152,GO:0009432,GO:0009605,GO:0009987,GO:0009991,GO:0030234,GO:0031668,GO:0033554,GO:0034641,GO:0042802,GO:0043085,GO:0043170,GO:0044093,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050790,GO:0050896,GO:0051716,GO:0065007,GO:0065009,GO:0071496,GO:0071704,GO:0090304,GO:0097159,GO:0098772,GO:1901360,GO:1901363	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD1_k127_6412687_13	187272.Mlg_0394	6.502e-110	371.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,1RMD8@1236|Gammaproteobacteria,1WWN1@135613|Chromatiales	135613|Chromatiales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_6412687_27	1382359.JIAL01000001_gene2144	3.236e-48	177.0	COG1259@1|root,COG1259@2|Bacteria,3Y4QD@57723|Acidobacteria,2JJ7J@204432|Acidobacteriia	204432|Acidobacteriia	S	Bifunctional nuclease	-	-	-	ko:K08999	-	-	-	-	ko00000	-	-	-	DNase-RNase
HKD1_k127_6412687_16	1047013.AQSP01000134_gene1378	4.717e-88	297.0	COG1192@1|root,COG1192@2|Bacteria,2NP2C@2323|unclassified Bacteria	2|Bacteria	D	Cobyrinic acid ac-diamide synthase	parA	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_6412687_36	391595.RLO149_c041720	2.113e-37	151.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2P0ZD@2433|Roseobacter	28211|Alphaproteobacteria	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_6412687_37	177437.HRM2_33460	1.169e-36	151.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2MJDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6412687_4	1089544.KB912942_gene3562	6.87e-186	596.0	COG0531@1|root,COG0531@2|Bacteria,2GJ75@201174|Actinobacteria,4E276@85010|Pseudonocardiales	201174|Actinobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_6412687_60	1037409.BJ6T_34240	0.0001679	54.0	COG3710@1|root,COG3903@1|root,COG3710@2|Bacteria,COG3903@2|Bacteria,1MWPD@1224|Proteobacteria,2UR5C@28211|Alphaproteobacteria,3K2Y2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	NB-ARC domain	-	-	-	-	-	-	-	-	-	-	-	-	NB-ARC,Trans_reg_C
HKD1_k127_6412687_6	665956.HMPREF1032_01597	2.043e-174	554.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,3WGI3@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_6412687_2	211165.AJLN01000051_gene4874	2.498e-201	633.0	COG0499@1|root,COG0499@2|Bacteria,1G1MN@1117|Cyanobacteria,1JJ5C@1189|Stigonemataceae	1117|Cyanobacteria	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	ahcY	GO:0000096,GO:0003674,GO:0003824,GO:0004013,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006534,GO:0006555,GO:0006575,GO:0006725,GO:0006732,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009066,GO:0009069,GO:0009116,GO:0009119,GO:0009987,GO:0016787,GO:0016801,GO:0016802,GO:0017144,GO:0019752,GO:0033353,GO:0034641,GO:0042278,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046128,GO:0046439,GO:0046483,GO:0046498,GO:0046500,GO:0051186,GO:0055086,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564,GO:1901605,GO:1901657	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_6412687_45	1173024.KI912149_gene5984	7.406e-26	111.0	2BXAG@1|root,32RI7@2|Bacteria,1G7CZ@1117|Cyanobacteria,1JKUI@1189|Stigonemataceae	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412687_17	240015.ACP_0114	3.329e-84	307.0	COG0795@1|root,COG0795@2|Bacteria,3Y2F9@57723|Acidobacteria,2JI5V@204432|Acidobacteriia	204432|Acidobacteriia	S	Permease, YjgP YjgQ	-	-	-	-	-	-	-	-	-	-	-	-	YjgP_YjgQ
HKD1_k127_6412687_42	204669.Acid345_1193	1.441e-28	124.0	COG1381@1|root,COG1381@2|Bacteria,3Y4AX@57723|Acidobacteria,2JJ0T@204432|Acidobacteriia	204432|Acidobacteriia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD1_k127_6412687_59	1267535.KB906767_gene2240	0.0001409	46.0	2DG6A@1|root,2ZUQ0@2|Bacteria,3Y8Y2@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412687_50	278963.ATWD01000001_gene1807	9.492e-19	91.0	2B6R1@1|root,31ZPU@2|Bacteria,3Y4VP@57723|Acidobacteria,2JJGV@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6412687_8	1121085.AUCI01000002_gene3911	4.956e-128	420.0	COG3876@1|root,COG3876@2|Bacteria,1VRMG@1239|Firmicutes,4HA8F@91061|Bacilli,1ZBF3@1386|Bacillus	91061|Bacilli	S	protein conserved in bacteria	ybbC	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD1_k127_6412687_20	1191523.MROS_1806	1.405e-69	244.0	COG1028@1|root,COG1028@2|Bacteria	1191523.MROS_1806|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	-
HKD1_k127_6412687_31	638301.HMPREF0444_0767	2.145e-42	162.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,4HI59@91061|Bacilli,27G5D@186828|Carnobacteriaceae	91061|Bacilli	S	Peptidase C26	puuD	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD1_k127_6419629_19	1449126.JQKL01000019_gene3223	7.491e-50	180.0	COG1092@1|root,COG1092@2|Bacteria,1TRAJ@1239|Firmicutes,247TI@186801|Clostridia,267QC@186813|unclassified Clostridiales	186801|Clostridia	J	Psort location Cytoplasmic, score	rlmI	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM,PUA
HKD1_k127_6419629_23	247490.KSU1_C1161	5.981e-31	132.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria	2|Bacteria	S	peptidyl-tyrosine sulfation	yidC	-	-	ko:K03217,ko:K06872	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,DUF4124,PDZ_2,Peptidase_C11,SLH,TPM_phosphatase,TPR_11,Trypsin_2,YidC_periplas
HKD1_k127_6419629_18	234267.Acid_1209	3.266e-61	216.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_6419629_8	1267535.KB906767_gene1129	3.174e-151	514.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_6419629_3	1340493.JNIF01000003_gene3421	5.813e-270	864.0	COG1629@1|root,COG1629@2|Bacteria,3Y67H@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_6419629_22	595460.RRSWK_07231	2.335e-32	134.0	COG4914@1|root,COG4914@2|Bacteria,2J4D4@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6419629_1	234267.Acid_3204	5.48e-301	955.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HKD1_k127_6419629_20	204669.Acid345_0581	3.499e-47	177.0	COG1974@1|root,COG1974@2|Bacteria,3Y47Z@57723|Acidobacteria,2JIJ3@204432|Acidobacteriia	204432|Acidobacteriia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD1_k127_6419629_10	700598.Niako_1577	2.751e-88	304.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,4NESR@976|Bacteroidetes,1IQI9@117747|Sphingobacteriia	976|Bacteroidetes	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD1_k127_6419629_15	1128421.JAGA01000002_gene1139	2.862e-69	240.0	COG3663@1|root,COG3663@2|Bacteria,2NRDF@2323|unclassified Bacteria	2|Bacteria	L	Uracil DNA glycosylase superfamily	mug	GO:0000700,GO:0003674,GO:0003824,GO:0004844,GO:0006139,GO:0006259,GO:0006281,GO:0006284,GO:0006285,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008263,GO:0009987,GO:0016787,GO:0016798,GO:0016799,GO:0019104,GO:0033554,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:0097506,GO:0140097,GO:1901360	3.2.2.28,6.3.3.2	ko:K01934,ko:K03649	ko00670,ko01100,ko03410,map00670,map01100,map03410	-	R02301	RC00183	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_6419629_16	234267.Acid_7380	2.834e-67	260.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y3HX@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K08884	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_6419629_27	661478.OP10G_3691	2.312e-09	59.0	2E328@1|root,32Y2G@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6419629_11	234267.Acid_2024	1.506e-87	295.0	COG1801@1|root,COG1801@2|Bacteria,3Y2WS@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_6419629_4	1382359.JIAL01000001_gene1484	1.277e-222	716.0	COG0210@1|root,COG0210@2|Bacteria,3Y2W8@57723|Acidobacteria,2JIDH@204432|Acidobacteriia	204432|Acidobacteriia	L	PFAM UvrD REP helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_6419629_26	1267535.KB906767_gene2260	3.253e-18	92.0	COG3584@1|root,COG3584@2|Bacteria,3Y8W5@57723|Acidobacteria	57723|Acidobacteria	S	3D domain	-	-	-	-	-	-	-	-	-	-	-	-	3D
HKD1_k127_6419629_24	309807.SRU_2819	4.182e-21	102.0	COG0526@1|root,COG0526@2|Bacteria,4PIEG@976|Bacteroidetes,1FK6M@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_6419629_9	1120971.AUCA01000011_gene2996	1.157e-89	308.0	COG4448@1|root,COG4448@2|Bacteria,1TRWI@1239|Firmicutes,4HAM1@91061|Bacilli,27A7C@186823|Alicyclobacillaceae	91061|Bacilli	E	L-asparaginase II	-	-	-	-	-	-	-	-	-	-	-	-	Asparaginase_II
HKD1_k127_6419629_30	706587.Desti_1655	0.0006317	43.0	COG1943@1|root,COG1943@2|Bacteria,1NA94@1224|Proteobacteria	1224|Proteobacteria	L	Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_6419629_6	1303518.CCALI_00899	2.648e-164	528.0	COG0423@1|root,COG0423@2|Bacteria	2|Bacteria	J	glycyl-tRNA aminoacylation	glyQS	GO:0000166,GO:0000287,GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006139,GO:0006399,GO:0006412,GO:0006418,GO:0006426,GO:0006518,GO:0006520,GO:0006725,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009345,GO:0009987,GO:0010467,GO:0016070,GO:0016594,GO:0016597,GO:0016874,GO:0016875,GO:0017076,GO:0019538,GO:0019752,GO:0030554,GO:0031406,GO:0032553,GO:0032555,GO:0032559,GO:0032991,GO:0034641,GO:0034645,GO:0034660,GO:0035639,GO:0036094,GO:0042165,GO:0042802,GO:0042803,GO:0043038,GO:0043039,GO:0043043,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0043177,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046872,GO:0046983,GO:0071704,GO:0090304,GO:0097159,GO:0097367,GO:0140098,GO:0140101,GO:1901265,GO:1901360,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1902494	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	iSB619.SA_RS07880	HGTP_anticodon,tRNA-synt_2b
HKD1_k127_6419629_21	1095769.CAHF01000015_gene2795	8.339e-39	149.0	COG4922@1|root,COG4922@2|Bacteria,1RDM5@1224|Proteobacteria,2VSBK@28216|Betaproteobacteria	28216|Betaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HKD1_k127_6419629_7	926569.ANT_07690	2.944e-163	524.0	COG0162@1|root,COG0162@2|Bacteria,2G64J@200795|Chloroflexi	200795|Chloroflexi	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD1_k127_6419629_14	344747.PM8797T_25501	1.046e-69	246.0	COG0457@1|root,COG0457@2|Bacteria,2IZTX@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6419629_28	530564.Psta_3388	4.646e-09	61.0	COG0457@1|root,COG0457@2|Bacteria,2IZTX@203682|Planctomycetes	203682|Planctomycetes	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6419629_5	861299.J421_1410	4.03e-184	585.0	COG0624@1|root,COG0624@2|Bacteria,1ZSYH@142182|Gemmatimonadetes	142182|Gemmatimonadetes	E	Peptidase family M28	-	-	3.5.1.6,3.5.1.87	ko:K06016	ko00240,ko01100,map00240,map01100	M00046	R00905,R04666	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_6419629_2	1237149.C900_02054	2.237e-285	899.0	COG5549@1|root,COG5549@2|Bacteria,4NEA0@976|Bacteroidetes,47YDB@768503|Cytophagia	976|Bacteroidetes	O	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117,DUF5118
HKD1_k127_6419629_12	479434.Sthe_3373	2.682e-85	296.0	COG0654@1|root,COG0654@2|Bacteria,2G66I@200795|Chloroflexi	200795|Chloroflexi	C	PFAM monooxygenase FAD-binding	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD1_k127_6419629_17	373994.Riv7116_6853	2.483e-61	239.0	COG1672@1|root,COG4995@1|root,COG1672@2|Bacteria,COG4995@2|Bacteria,1G0F4@1117|Cyanobacteria,1HJ3S@1161|Nostocales	1117|Cyanobacteria	I	AAA-like domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_35
HKD1_k127_6419629_29	489825.LYNGBM3L_60180	0.0001162	56.0	COG0457@1|root,COG0457@2|Bacteria,1G524@1117|Cyanobacteria,1HAVS@1150|Oscillatoriales	1117|Cyanobacteria	S	Tetratricopeptide repeats	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_6419629_25	1906.SFRA_16920	3.037e-19	104.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria	201174|Actinobacteria	KLT	serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_6419629_0	234267.Acid_3931	0.0	1389.0	COG2866@1|root,COG2866@2|Bacteria,3Y3X8@57723|Acidobacteria	57723|Acidobacteria	E	Peptidase M14, carboxypeptidase A	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD1_k127_6419629_13	215803.DB30_8023	7.537e-80	271.0	COG0243@1|root,COG0243@2|Bacteria,1NS3T@1224|Proteobacteria,42M9Q@68525|delta/epsilon subdivisions,2X7DH@28221|Deltaproteobacteria,2YUKN@29|Myxococcales	28221|Deltaproteobacteria	C	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Molybdopterin,Molydop_binding
HKD1_k127_6423444_36	1191523.MROS_1703	6.938e-56	203.0	COG2120@1|root,COG2120@2|Bacteria	2|Bacteria	S	N-acetylglucosaminylinositol deacetylase activity	bshB1	-	-	ko:K01463	-	-	-	-	ko00000,ko01000	-	-	-	PIG-L
HKD1_k127_6423444_56	861299.J421_0340	1.789e-17	93.0	COG3595@1|root,COG3595@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097,PA14
HKD1_k127_6423444_64	1384056.N787_04785	1.365e-06	59.0	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD1_k127_6423444_67	1267535.KB906767_gene1042	2.599e-05	55.0	COG5662@1|root,COG5662@2|Bacteria,3Y4S0@57723|Acidobacteria	57723|Acidobacteria	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6423444_34	1198114.AciX9_2646	2.638e-61	217.0	COG1595@1|root,COG1595@2|Bacteria,3Y3HD@57723|Acidobacteria,2JHY0@204432|Acidobacteriia	204432|Acidobacteriia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6423444_39	234267.Acid_7838	2.425e-48	197.0	COG4252@1|root,COG5002@1|root,COG4252@2|Bacteria,COG5002@2|Bacteria,3Y7KI@57723|Acidobacteria	57723|Acidobacteria	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,HATPase_c,HisKA
HKD1_k127_6423444_17	338963.Pcar_0819	7.788e-112	377.0	COG1921@1|root,COG1921@2|Bacteria,1MWXI@1224|Proteobacteria,42MU7@68525|delta/epsilon subdivisions,2WJFQ@28221|Deltaproteobacteria,43S0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	GO:0003674,GO:0003824,GO:0004125,GO:0006139,GO:0006399,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016070,GO:0016740,GO:0016785,GO:0018130,GO:0019438,GO:0032774,GO:0034641,GO:0034654,GO:0034660,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0046483,GO:0071704,GO:0090304,GO:0097056,GO:0140098,GO:0140101,GO:1901360,GO:1901362,GO:1901576	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD1_k127_6423444_54	204669.Acid345_0269	1.864e-23	109.0	2ENGH@1|root,33G40@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6423444_51	207954.MED92_03248	4.602e-25	106.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,1SCA7@1236|Gammaproteobacteria,1XM5A@135619|Oceanospirillales	135619|Oceanospirillales	K	cold-shock protein	cspG	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_6423444_14	880073.Calab_2857	8.172e-143	479.0	COG0265@1|root,COG0265@2|Bacteria	2|Bacteria	O	serine-type endopeptidase activity	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	DUF2808,Peptidase_S46
HKD1_k127_6423444_45	1111454.HMPREF1250_1799	8.885e-39	157.0	COG0739@1|root,COG0739@2|Bacteria,1V3ZU@1239|Firmicutes,4H4HE@909932|Negativicutes	909932|Negativicutes	M	Peptidase, M23 family	envC_2	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_6423444_58	234267.Acid_0791	7.236e-12	75.0	2DMGW@1|root,32REM@2|Bacteria,3Y4XX@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zf-B_box
HKD1_k127_6423444_43	234267.Acid_0793	1.226e-45	171.0	COG1595@1|root,COG1595@2|Bacteria,3Y4HK@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6423444_55	404380.Gbem_2598	1.302e-19	101.0	COG0392@1|root,COG0392@2|Bacteria,1R98C@1224|Proteobacteria,42U6V@68525|delta/epsilon subdivisions,2WKTZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD1_k127_6423444_33	204669.Acid345_4041	5.514e-64	222.0	COG1327@1|root,COG1327@2|Bacteria,3Y4GA@57723|Acidobacteria,2JJC7@204432|Acidobacteriia	204432|Acidobacteriia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_6423444_57	98439.AJLL01000077_gene3102	1.992e-13	77.0	COG0071@1|root,COG0071@2|Bacteria,1GDIQ@1117|Cyanobacteria	1117|Cyanobacteria	O	Hsp20/alpha crystallin family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_6423444_1	289376.THEYE_A0859	5.374e-299	937.0	COG0466@1|root,COG0466@2|Bacteria,3J0DQ@40117|Nitrospirae	40117|Nitrospirae	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	-	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_6423444_32	1267535.KB906767_gene3354	5.186e-65	244.0	COG0741@1|root,COG1388@1|root,COG0741@2|Bacteria,COG1388@2|Bacteria,3Y38S@57723|Acidobacteria,2JHZB@204432|Acidobacteriia	204432|Acidobacteriia	M	Lysin motif	-	-	-	ko:K08307	-	-	-	-	ko00000,ko01000,ko01011	-	-	-	LysM,SLT
HKD1_k127_6423444_8	335543.Sfum_2637	1.026e-175	565.0	COG0606@1|root,COG0606@2|Bacteria,1MU4R@1224|Proteobacteria,42NBJ@68525|delta/epsilon subdivisions,2WJ52@28221|Deltaproteobacteria,2MQX1@213462|Syntrophobacterales	28221|Deltaproteobacteria	O	PFAM magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_6423444_3	1267534.KB906754_gene3849	8.852e-260	814.0	COG0308@1|root,COG0308@2|Bacteria,3Y5B2@57723|Acidobacteria,2JKG0@204432|Acidobacteriia	204432|Acidobacteriia	E	Peptidase family M1 domain	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M1
HKD1_k127_6423444_0	1183438.GKIL_2068	2.318e-313	975.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	3.4.17.21	ko:K01301	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PA,Peptidase_M28,TFR_dimer
HKD1_k127_6423444_47	1267535.KB906767_gene4113	9.427e-32	129.0	COG2940@1|root,COG2940@2|Bacteria,3Y7R1@57723|Acidobacteria	57723|Acidobacteria	S	SET domain	-	-	-	ko:K07117	-	-	-	-	ko00000	-	-	-	SET
HKD1_k127_6423444_53	661478.OP10G_4286	4.078e-24	108.0	2EKVR@1|root,33EJ9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6423444_5	706587.Desti_0542	2.843e-200	651.0	COG2304@1|root,COG2304@2|Bacteria,1MW8K@1224|Proteobacteria,42NNC@68525|delta/epsilon subdivisions,2WKQW@28221|Deltaproteobacteria,2MQ7A@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VIT,VWA_3
HKD1_k127_6423444_49	1267535.KB906767_gene9	3.39e-28	128.0	COG0810@1|root,COG0810@2|Bacteria,3Y4BU@57723|Acidobacteria,2JJ3R@204432|Acidobacteriia	204432|Acidobacteriia	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	TonB_C
HKD1_k127_6423444_23	358220.C380_04965	3.404e-88	297.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2VIGI@28216|Betaproteobacteria,4A9XQ@80864|Comamonadaceae	28216|Betaproteobacteria	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_6423444_41	1379270.AUXF01000002_gene1539	1.512e-47	176.0	2C7E0@1|root,330TX@2|Bacteria,1ZUQG@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6423444_30	1144275.COCOR_06244	1.773e-75	263.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,42P58@68525|delta/epsilon subdivisions,2WKYK@28221|Deltaproteobacteria,2YY1K@29|Myxococcales	28221|Deltaproteobacteria	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	iAF987.Gmet_0547	Asp_Glu_race
HKD1_k127_6423444_26	489825.LYNGBM3L_17170	3.731e-81	297.0	COG5555@1|root,COG5555@2|Bacteria,1GR73@1117|Cyanobacteria	2|Bacteria	N	Integrin alpha (beta-propellor repeats).	-	-	-	-	-	-	-	-	-	-	-	-	FG-GAP
HKD1_k127_6423444_21	1122604.JONR01000025_gene4602	3.279e-90	321.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_6423444_63	1121481.AUAS01000005_gene1767	3.026e-07	51.0	COG2318@1|root,COG2318@2|Bacteria,4NNRD@976|Bacteroidetes,47PZE@768503|Cytophagia	976|Bacteroidetes	S	DinB family	-	-	-	-	-	-	-	-	-	-	-	-	DinB
HKD1_k127_6423444_61	56780.SYN_01756	6.153e-09	69.0	COG4726@1|root,COG4726@2|Bacteria,1NK1B@1224|Proteobacteria	1224|Proteobacteria	NU	Pilus assembly protein PilX	-	-	-	ko:K02673	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	PilX_N
HKD1_k127_6423444_11	1382359.JIAL01000001_gene2604	1e-151	511.0	COG5009@1|root,COG5009@2|Bacteria,3Y31C@57723|Acidobacteria,2JHJY@204432|Acidobacteriia	204432|Acidobacteriia	M	Penicillin-binding protein 1A	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_6423444_25	945713.IALB_2676	2.954e-81	279.0	COG4947@1|root,COG4947@2|Bacteria	2|Bacteria	P	esterase	XK27_05675	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD1_k127_6423444_2	1429046.RR21198_0312	2.709e-263	831.0	COG4447@1|root,COG4447@2|Bacteria,2I4PF@201174|Actinobacteria	201174|Actinobacteria	E	Zinc metalloprotease (Elastase)	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_6423444_27	234267.Acid_6501	1.203e-80	279.0	COG2897@1|root,COG2897@2|Bacteria,3Y7T0@57723|Acidobacteria	57723|Acidobacteria	M	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_6423444_9	234267.Acid_1867	6.116e-158	507.0	COG0665@1|root,COG0665@2|Bacteria,3Y5BS@57723|Acidobacteria	57723|Acidobacteria	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303,ko:K21061	ko00260,ko00330,ko01100,map00260,map00330,map01100	-	R00610,R11428	RC00060,RC00135,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_6423444_4	204669.Acid345_0064	5.19e-255	801.0	COG0465@1|root,COG0465@2|Bacteria,3Y2UK@57723|Acidobacteria,2JI9D@204432|Acidobacteriia	204432|Acidobacteriia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_6423444_38	477974.Daud_0086	1.658e-50	194.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,260U4@186807|Peptococcaceae	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD1_k127_6423444_37	1157490.EL26_08735	6.278e-51	187.0	COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,4HFZX@91061|Bacilli,2789X@186823|Alicyclobacillaceae	91061|Bacilli	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_6423444_22	204669.Acid345_3612	3.04e-89	303.0	COG0382@1|root,COG0382@2|Bacteria,3Y3CW@57723|Acidobacteria,2JIHD@204432|Acidobacteriia	204432|Acidobacteriia	H	PFAM UbiA prenyltransferase	-	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_6423444_16	926566.Terro_1502	2.445e-117	388.0	COG1060@1|root,COG1060@2|Bacteria,3Y331@57723|Acidobacteria,2JITB@204432|Acidobacteriia	204432|Acidobacteriia	H	Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3- (1- carboxyvinyl)oxy benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate	mqnE	-	2.5.1.120	ko:K18285	ko00130,ko01110,map00130,map01110	-	R10667	RC00021,RC03234	ko00000,ko00001,ko01000	-	-	-	Radical_SAM
HKD1_k127_6423444_18	1158338.JNLJ01000005_gene1771	9.478e-106	350.0	COG2107@1|root,COG2107@2|Bacteria,2G4EE@200783|Aquificae	200783|Aquificae	S	Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnD	-	-	ko:K11785	ko00130,ko01110,map00130,map01110	-	R08589	RC02330	ko00000,ko00001,ko01000	-	-	-	VitK2_biosynth
HKD1_k127_6423444_28	546271.Selsp_1107	1.874e-80	285.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,4H2D1@909932|Negativicutes	909932|Negativicutes	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD1_k127_6423444_65	1029824.AFID01000011_gene875	9.042e-06	55.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,2GJ1J@201174|Actinobacteria,1W8KD@1268|Micrococcaceae	201174|Actinobacteria	KLT	Serine threonine protein kinase	pknB	GO:0000270,GO:0003674,GO:0003824,GO:0004672,GO:0004674,GO:0005488,GO:0005515,GO:0005575,GO:0005618,GO:0005623,GO:0006022,GO:0006023,GO:0006024,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0008047,GO:0008150,GO:0008152,GO:0008360,GO:0009058,GO:0009059,GO:0009252,GO:0009273,GO:0009605,GO:0009607,GO:0009889,GO:0009890,GO:0009892,GO:0009987,GO:0010565,GO:0010698,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019216,GO:0019217,GO:0019222,GO:0019538,GO:0022603,GO:0022604,GO:0030145,GO:0030203,GO:0030234,GO:0030312,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0032091,GO:0034645,GO:0036211,GO:0040007,GO:0042304,GO:0042546,GO:0042802,GO:0043085,GO:0043086,GO:0043167,GO:0043169,GO:0043170,GO:0043207,GO:0043388,GO:0043393,GO:0043412,GO:0044036,GO:0044038,GO:0044085,GO:0044092,GO:0044093,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044403,GO:0044419,GO:0044464,GO:0045717,GO:0045833,GO:0045922,GO:0046777,GO:0046872,GO:0046890,GO:0046914,GO:0048519,GO:0048523,GO:0050789,GO:0050790,GO:0050793,GO:0050794,GO:0050896,GO:0051055,GO:0051098,GO:0051099,GO:0051100,GO:0051101,GO:0051128,GO:0051701,GO:0051704,GO:0051707,GO:0052173,GO:0052200,GO:0052564,GO:0052572,GO:0062012,GO:0062014,GO:0065007,GO:0065008,GO:0065009,GO:0070589,GO:0071554,GO:0071704,GO:0071840,GO:0071944,GO:0075136,GO:0080090,GO:0098772,GO:0140096,GO:1901135,GO:1901137,GO:1901564,GO:1901566,GO:1901576	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_6423444_29	1278073.MYSTI_06917	5.291e-76	260.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,42NC0@68525|delta/epsilon subdivisions,2WJK9@28221|Deltaproteobacteria,2YURC@29|Myxococcales	28221|Deltaproteobacteria	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_6423444_46	401053.AciPR4_0529	2.331e-32	144.0	COG4105@1|root,COG4105@2|Bacteria,3Y36S@57723|Acidobacteria,2JHVA@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM Outer membrane assembly lipoprotein YfiO	-	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD1_k127_6423444_13	765869.BDW_14150	2.513e-145	469.0	COG2805@1|root,COG2805@2|Bacteria,1MU3J@1224|Proteobacteria,42M7F@68525|delta/epsilon subdivisions,2MSP9@213481|Bdellovibrionales,2WIMF@28221|Deltaproteobacteria	213481|Bdellovibrionales	NU	twitching motility protein	pilT-4	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_6423444_35	204669.Acid345_2003	6.426e-61	241.0	COG4726@1|root,COG4726@2|Bacteria	2|Bacteria	NU	Pilus assembly protein PilX	-	-	-	-	-	-	-	-	-	-	-	-	Bactofilin,DUF3494,PilX_N
HKD1_k127_6423444_10	525897.Dbac_2296	3.082e-153	496.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,42N97@68525|delta/epsilon subdivisions,2WKVE@28221|Deltaproteobacteria,2M7ZJ@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Transporter-associated region	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_6423444_15	671143.DAMO_0704	9.741e-122	401.0	COG0404@1|root,COG0404@2|Bacteria,2NNSR@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD1_k127_6423444_42	1120973.AQXL01000134_gene1511	1.068e-46	171.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,4HIMA@91061|Bacilli,279UB@186823|Alicyclobacillaceae	91061|Bacilli	E	Is also involved in protein lipoylation via its role as an octanoyl lipoyl carrier protein intermediate	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD1_k127_6423444_12	671143.DAMO_0706	1.335e-148	482.0	COG0403@1|root,COG0403@2|Bacteria,2NNP1@2323|unclassified Bacteria	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	GO:0001505,GO:0003674,GO:0003824,GO:0004375,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005960,GO:0006082,GO:0006520,GO:0006544,GO:0006807,GO:0008150,GO:0008152,GO:0009069,GO:0009987,GO:0016491,GO:0016638,GO:0016642,GO:0017144,GO:0019752,GO:0032991,GO:0042133,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044444,GO:0044464,GO:0055114,GO:0065007,GO:0065008,GO:0071704,GO:1901564,GO:1901605,GO:1902494,GO:1990204	1.4.4.2	ko:K00281,ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko00002,ko01000	-	-	-	GDC-P
HKD1_k127_6423444_7	204669.Acid345_2458	5.886e-190	606.0	COG1003@1|root,COG1003@2|Bacteria,3Y2UZ@57723|Acidobacteria,2JIAN@204432|Acidobacteriia	204432|Acidobacteriia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD1_k127_6423444_31	84531.JMTZ01000038_gene3637	8.69e-70	249.0	COG3501@1|root,COG3501@2|Bacteria,1MU7Q@1224|Proteobacteria,1RZ3X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	protein and some similarities with VgrG protein	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPD
HKD1_k127_6423444_50	32057.KB217483_gene9063	1.147e-26	113.0	COG3170@1|root,COG3170@2|Bacteria,1G596@1117|Cyanobacteria,1HSNU@1161|Nostocales	1117|Cyanobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6423444_48	1121920.AUAU01000022_gene2473	1.601e-28	119.0	COG3411@1|root,COG3411@2|Bacteria,3Y54Q@57723|Acidobacteria	57723|Acidobacteria	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6423444_44	247490.KSU1_D0595	1.395e-43	178.0	COG0265@1|root,COG0265@2|Bacteria,2J23K@203682|Planctomycetes	203682|Planctomycetes	OT	Forkhead associated domain	-	-	-	-	-	-	-	-	-	-	-	-	FHA,Trypsin_2
HKD1_k127_6423444_40	204669.Acid345_0559	2.905e-48	196.0	COG4591@1|root,COG4591@2|Bacteria	2|Bacteria	M	lipoprotein localization to outer membrane	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,LolA_like,MacB_PCD
HKD1_k127_6423444_24	1296416.JACB01000004_gene1170	1.003e-84	303.0	COG2312@1|root,COG2382@1|root,COG2312@2|Bacteria,COG2382@2|Bacteria,4NF9R@976|Bacteroidetes,1I4ES@117743|Flavobacteriia	976|Bacteroidetes	P	Erythromycin esterase	-	-	-	ko:K06880	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	Erythro_esteras
HKD1_k127_6423444_19	204669.Acid345_1110	8.482e-105	346.0	COG3217@1|root,COG3217@2|Bacteria,3Y5TQ@57723|Acidobacteria,2JNG0@204432|Acidobacteriia	204432|Acidobacteriia	S	MOSC N-terminal beta barrel domain	-	-	-	ko:K07140	-	-	-	-	ko00000	-	-	-	MOSC,MOSC_N
HKD1_k127_6423444_52	2002.JOEQ01000009_gene6434	6.401e-25	113.0	COG3371@1|root,COG3371@2|Bacteria,2IMS7@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF998)	-	-	-	-	-	-	-	-	-	-	-	-	DUF998
HKD1_k127_6423444_60	761193.Runsl_1483	2.269e-09	63.0	COG4319@1|root,COG4319@2|Bacteria,4NSA0@976|Bacteroidetes,47RMW@768503|Cytophagia	976|Bacteroidetes	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_6443543_10	530564.Psta_3548	2.245e-38	149.0	COG2062@1|root,COG2062@2|Bacteria,2J0N8@203682|Planctomycetes	203682|Planctomycetes	T	phosphohistidine phosphatase, SixA	-	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD1_k127_6443543_15	240016.ABIZ01000001_gene988	2.233e-10	61.0	COG1943@1|root,COG1943@2|Bacteria,46VP6@74201|Verrucomicrobia,2IVSQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_6443543_4	485913.Krac_9228	6.495e-92	307.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.1.1.45,2.7.4.9,4.1.1.19	ko:K00560,ko:K00943,ko:K01585	ko00240,ko00330,ko00670,ko01100,ko01523,map00240,map00330,map00670,map01100,map01523	M00053,M00133	R00566,R02094,R02098,R02101	RC00002,RC00219,RC00299,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HKD1_k127_6443543_6	485913.Krac_9227	1.437e-73	258.0	COG0125@1|root,COG0125@2|Bacteria	2|Bacteria	F	dTDP biosynthetic process	tmk	GO:0000166,GO:0000287,GO:0001882,GO:0001883,GO:0003674,GO:0003824,GO:0004798,GO:0005488,GO:0005515,GO:0005524,GO:0005525,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009129,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009161,GO:0009165,GO:0009173,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009218,GO:0009219,GO:0009221,GO:0009259,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0017076,GO:0018130,GO:0019001,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0019693,GO:0030554,GO:0032549,GO:0032550,GO:0032553,GO:0032555,GO:0032559,GO:0032561,GO:0034641,GO:0034654,GO:0035639,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046044,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046872,GO:0046940,GO:0046983,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:0097159,GO:0097367,GO:1901135,GO:1901137,GO:1901265,GO:1901293,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.7.4.9,4.1.1.19	ko:K00943,ko:K01585	ko00240,ko00330,ko01100,map00240,map00330,map01100	M00053,M00133	R00566,R02094,R02098	RC00002,RC00299	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS00680,iJN746.PP_3363,iNJ661.Rv3247c	AAA_33,Thymidylate_kin
HKD1_k127_6443543_5	321327.CYA_2432	1.221e-85	303.0	COG0248@1|root,COG0248@2|Bacteria,1FZZC@1117|Cyanobacteria,1GYWM@1129|Synechococcus	1117|Cyanobacteria	FP	exopolyphosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HKD1_k127_6443543_12	456442.Mboo_1455	3.777e-26	120.0	COG5607@1|root,arCOG05139@2157|Archaea	2157|Archaea	T	CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH,HD,Metallophos_2
HKD1_k127_6443543_14	204669.Acid345_3899	6.566e-20	92.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	ynjA	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_6443543_1	1173027.Mic7113_3665	9.24e-161	512.0	COG0667@1|root,COG0667@2|Bacteria,1G3RI@1117|Cyanobacteria,1HHEI@1150|Oscillatoriales	1117|Cyanobacteria	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_6443543_8	318464.IO99_17415	1.603e-49	183.0	COG4845@1|root,COG4845@2|Bacteria,1V9NV@1239|Firmicutes,24FCQ@186801|Clostridia,36EY0@31979|Clostridiaceae	186801|Clostridia	V	Chloramphenicol acetyltransferase	-	-	2.3.1.28	ko:K19271	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	CAT
HKD1_k127_6443543_0	1267534.KB906755_gene4695	0.0	1034.0	COG1629@1|root,COG4771@2|Bacteria,3Y33S@57723|Acidobacteria,2JK9M@204432|Acidobacteriia	204432|Acidobacteriia	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_6443543_7	234267.Acid_7893	2.999e-50	186.0	COG0546@1|root,COG0546@2|Bacteria	2|Bacteria	S	glycolate biosynthetic process	ppaX	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006725,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008967,GO:0009987,GO:0016311,GO:0016787,GO:0016788,GO:0016791,GO:0033554,GO:0034641,GO:0042578,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0050896,GO:0051716,GO:0071704,GO:0090304,GO:1901360	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019,ko:K13292	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_6443543_2	861299.J421_2707	9.305e-144	477.0	COG1022@1|root,COG1022@2|Bacteria,1ZT60@142182|Gemmatimonadetes	142182|Gemmatimonadetes	I	AMP-binding enzyme	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD1_k127_6443543_9	671143.DAMO_2346	5.357e-42	173.0	COG0484@1|root,COG3307@1|root,COG0484@2|Bacteria,COG3307@2|Bacteria,2NPHS@2323|unclassified Bacteria	2|Bacteria	M	O-Antigen ligase	-	-	-	ko:K02847	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	9.B.67.4,9.B.67.5	-	-	DnaJ,Wzy_C
HKD1_k127_6443543_13	682795.AciX8_1491	6.548e-20	103.0	COG2956@1|root,COG2956@2|Bacteria	2|Bacteria	G	lipopolysaccharide metabolic process	-	-	-	ko:K08309,ko:K19804	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	TPR_16,TPR_19,TPR_2,TPR_6,TPR_7,TPR_8
HKD1_k127_6443543_3	439235.Dalk_0708	1.016e-125	424.0	COG0472@1|root,COG1086@1|root,COG0472@2|Bacteria,COG1086@2|Bacteria,1MWYW@1224|Proteobacteria,42NVY@68525|delta/epsilon subdivisions,2X5IH@28221|Deltaproteobacteria,2MQ3P@213118|Desulfobacterales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 4	-	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	CoA_binding_3,Glycos_transf_4
HKD1_k127_6443543_11	1174528.JH992890_gene586	3.195e-37	144.0	COG3251@1|root,COG3251@2|Bacteria	2|Bacteria	P	PFAM MbtH domain protein	-	-	-	ko:K05375	ko00261,ko01130,map00261,map01130	M00736	R10880	RC00064,RC00141,RC03296,RC03297,RC03298	ko00000,ko00001,ko00002	-	-	-	CBF_beta,MbtH
HKD1_k127_6443543_17	1321778.HMPREF1982_02612	0.0009628	51.0	2EZXH@1|root,33T1S@2|Bacteria,1VRJK@1239|Firmicutes,24B4Z@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6451777_40	1267533.KB906733_gene2987	3.585e-60	221.0	COG2208@1|root,COG2208@2|Bacteria	2|Bacteria	T	phosphoserine phosphatase activity	rsbU	-	3.1.3.3	ko:K07315,ko:K16928	-	M00582	-	-	ko00000,ko00002,ko01000,ko02000,ko03021	3.A.1.33	-	-	HAMP,HATPase_c_2,SpoIIE,dCache_1
HKD1_k127_6451777_20	1267533.KB906733_gene2988	5.78e-102	337.0	COG0745@1|root,COG0745@2|Bacteria,3Y4D1@57723|Acidobacteria	57723|Acidobacteria	T	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6451777_6	1267533.KB906733_gene2989	1.741e-155	509.0	COG0642@1|root,COG2205@2|Bacteria,3Y2M7@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_6451777_74	485916.Dtox_4148	4.287e-07	56.0	COG4636@1|root,COG4636@2|Bacteria	2|Bacteria	D	protein conserved in cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_6451777_39	1121920.AUAU01000015_gene1127	5.302e-61	237.0	COG2385@1|root,COG2385@2|Bacteria,3Y370@57723|Acidobacteria	57723|Acidobacteria	D	Stage II sporulation protein	-	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SPOR,SpoIID
HKD1_k127_6451777_26	700598.Niako_6986	4.149e-90	311.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_6451777_38	1068980.ARVW01000001_gene7698	2.453e-61	226.0	COG1680@1|root,COG1680@2|Bacteria,2GJQG@201174|Actinobacteria,4E90E@85010|Pseudonocardiales	201174|Actinobacteria	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_6451777_32	330214.NIDE3038	6.231e-75	263.0	COG0673@1|root,COG0673@2|Bacteria,3J0M7@40117|Nitrospirae	40117|Nitrospirae	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA
HKD1_k127_6451777_44	404380.Gbem_2984	1.185e-49	197.0	COG1807@1|root,COG1807@2|Bacteria,1NMIZ@1224|Proteobacteria,42RXF@68525|delta/epsilon subdivisions,2WNF1@28221|Deltaproteobacteria,43TBY@69541|Desulfuromonadales	28221|Deltaproteobacteria	M	PFAM glycosyl transferase family 39	arnT	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_6451777_78	938293.CAJU020000003_gene1030	0.0001049	53.0	COG1073@1|root,COG1073@2|Bacteria,1TQYU@1239|Firmicutes,249J1@186801|Clostridia,22GTP@1570339|Peptoniphilaceae	186801|Clostridia	S	X-Pro dipeptidyl-peptidase (S15 family)	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	FSH1,Hydrolase_4,Peptidase_S9
HKD1_k127_6451777_55	649639.Bcell_3330	1.358e-22	106.0	COG0746@1|root,COG0746@2|Bacteria,1VA6T@1239|Firmicutes,4HPX3@91061|Bacilli,1ZIA7@1386|Bacillus	91061|Bacilli	H	Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor	mobA	-	2.7.7.77	ko:K03752	ko00790,ko01100,map00790,map01100	-	R11581	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_6451777_18	234267.Acid_0264	6.255e-103	357.0	COG1044@1|root,COG1044@2|Bacteria,3Y4K5@57723|Acidobacteria	57723|Acidobacteria	M	SpoIVB peptidase S55	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S55
HKD1_k127_6451777_56	204669.Acid345_0042	1.399e-22	106.0	COG0357@1|root,COG0357@2|Bacteria,3Y4W7@57723|Acidobacteria,2JJG7@204432|Acidobacteriia	204432|Acidobacteriia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD1_k127_6451777_27	1173028.ANKO01000147_gene1308	2.839e-87	307.0	COG0076@1|root,COG0076@2|Bacteria,1G3F8@1117|Cyanobacteria,1H9S6@1150|Oscillatoriales	1117|Cyanobacteria	E	PFAM Pyridoxal-dependent decarboxylase conserved domain	-	-	4.1.1.105,4.1.1.15,4.1.1.28,4.1.1.86	ko:K01580,ko:K01593,ko:K13745	ko00250,ko00260,ko00350,ko00360,ko00380,ko00410,ko00430,ko00650,ko00901,ko00950,ko00965,ko01100,ko01110,ko01120,ko02024,ko04726,ko04727,ko04728,ko04940,ko05030,ko05031,ko05034,map00250,map00260,map00350,map00360,map00380,map00410,map00430,map00650,map00901,map00950,map00965,map01100,map01110,map01120,map02024,map04726,map04727,map04728,map04940,map05030,map05031,map05034	M00027,M00037,M00042	R00261,R00489,R00685,R00699,R00736,R01682,R02080,R02466,R02701,R04909,R07650	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_6451777_2	661478.OP10G_1859	2.55e-184	597.0	COG0574@1|root,COG0574@2|Bacteria	2|Bacteria	G	Belongs to the PEP-utilizing enzyme family	-	-	2.7.9.1,2.7.9.2	ko:K01006,ko:K01007	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PPDK_N
HKD1_k127_6451777_28	886293.Sinac_2397	1.279e-82	286.0	COG1028@1|root,COG1028@2|Bacteria	886293.Sinac_2397|-	IQ	oxidoreductase activity, acting on CH-OH group of donors	-	-	1.3.1.34	ko:K13237	ko04146,map04146	-	-	-	ko00000,ko00001,ko01000	-	-	-	-
HKD1_k127_6451777_12	1131269.AQVV01000007_gene1011	4.251e-130	432.0	COG0147@1|root,COG0147@2|Bacteria	2|Bacteria	EH	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia	trpE	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_6451777_53	1380763.BG53_02405	2.425e-27	119.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,4H9V0@91061|Bacilli,26SQY@186822|Paenibacillaceae	91061|Bacilli	M	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K01802,ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD1_k127_6451777_57	6183.Smp_140520.2	2.167e-20	101.0	COG0666@1|root,KOG0504@2759|Eukaryota,39YNX@33154|Opisthokonta,3BFJC@33208|Metazoa,3CU3G@33213|Bilateria	33208|Metazoa	J	retrograde transport, endosome to plasma membrane	ANKRD50	GO:0006810,GO:0008150,GO:0016192,GO:0016197,GO:0046907,GO:0051179,GO:0051234,GO:0051641,GO:0051649,GO:0098876,GO:1990126	-	ko:K21440	-	-	-	-	ko00000,ko04131	-	-	-	AAA_16,Ank_2,Ank_4,Ank_5
HKD1_k127_6451777_29	635013.TherJR_1606	1.236e-78	267.0	COG0512@1|root,COG0512@2|Bacteria,1TT9R@1239|Firmicutes,24FR0@186801|Clostridia,261J7@186807|Peptococcaceae	186801|Clostridia	EH	TIGRFAM glutamine amidotransferase of anthranilate synthase	pabA	-	2.6.1.85,4.1.3.27	ko:K01658,ko:K01664	ko00400,ko00405,ko00790,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map00790,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986,R01716	RC00010,RC01418,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_6451777_25	1089553.Tph_c26530	9.78e-91	309.0	COG0512@1|root,COG0547@1|root,COG0512@2|Bacteria,COG0547@2|Bacteria,1TP8U@1239|Firmicutes,247WY@186801|Clostridia,42EK5@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18,4.1.3.27	ko:K00766,ko:K13497	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R00985,R00986,R01073	RC00010,RC00440,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_6451777_23	1382306.JNIM01000001_gene2650	5.186e-92	320.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,2G6GG@200795|Chloroflexi	200795|Chloroflexi	E	Belongs to the TrpC family	trpC	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS,PRAI
HKD1_k127_6451777_24	1123368.AUIS01000022_gene1052	3.162e-91	308.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,1RPW1@1236|Gammaproteobacteria,2NCI1@225057|Acidithiobacillales	225057|Acidithiobacillales	P	ABC transporter	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran
HKD1_k127_6451777_17	234267.Acid_7397	1.918e-107	367.0	COG1508@1|root,COG1508@2|Bacteria,3Y2M0@57723|Acidobacteria	57723|Acidobacteria	K	RNA polymerase sigma-54 factor	-	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_6451777_54	1499967.BAYZ01000065_gene6104	5.763e-27	117.0	COG1544@1|root,COG1544@2|Bacteria,2NPYS@2323|unclassified Bacteria	2|Bacteria	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	raiA	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosomal_S30AE
HKD1_k127_6451777_30	240015.ACP_0619	1.43e-78	273.0	COG1660@1|root,COG1660@2|Bacteria,3Y2HM@57723|Acidobacteria,2JHJM@204432|Acidobacteriia	204432|Acidobacteriia	S	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD1_k127_6451777_48	1499967.BAYZ01000065_gene6106	4.075e-32	131.0	COG2893@1|root,COG2893@2|Bacteria,2NRCX@2323|unclassified Bacteria	2|Bacteria	G	PTS system fructose IIA component	manX	-	2.7.1.191,2.7.1.194	ko:K02793,ko:K02794,ko:K02821	ko00051,ko00053,ko00520,ko01100,ko01120,ko02060,map00051,map00053,map00520,map01100,map01120,map02060	M00276,M00283,M00550	R02630,R07671	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1,4.A.7.1	-	-	EIIA-man
HKD1_k127_6451777_69	1121396.KB893096_gene3543	1.161e-12	80.0	COG1596@1|root,COG1596@2|Bacteria,1N7GP@1224|Proteobacteria,42QGU@68525|delta/epsilon subdivisions,2WMBM@28221|Deltaproteobacteria,2MI32@213118|Desulfobacterales	28221|Deltaproteobacteria	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_6451777_77	290633.GOX0939	9.58e-05	51.0	COG0438@1|root,COG0438@2|Bacteria,1MVIM@1224|Proteobacteria,2TR88@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	glycosyl transferase	-	-	-	ko:K20444	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.1.3	GT2,GT4	-	Glyco_trans_1_4,Glycos_transf_2
HKD1_k127_6451777_73	290512.Paes_1404	1.29e-07	61.0	COG1266@1|root,COG1266@2|Bacteria,1FFCE@1090|Chlorobi	1090|Chlorobi	S	PFAM Abortive infection protein	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_6451777_31	404380.Gbem_2215	9.515e-76	272.0	COG0477@1|root,COG2814@2|Bacteria,1NU31@1224|Proteobacteria,43CB2@68525|delta/epsilon subdivisions,2X7MH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	EGP	Major facilitator superfamily MFS_1	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_6451777_36	1408422.JHYF01000009_gene1999	4.983e-63	227.0	COG3635@1|root,COG3635@2|Bacteria,1UIDA@1239|Firmicutes,25EIA@186801|Clostridia	186801|Clostridia	G	Metalloenzyme superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Metalloenzyme
HKD1_k127_6451777_13	204669.Acid345_3274	3.292e-129	428.0	COG2204@1|root,COG2204@2|Bacteria,3Y3HH@57723|Acidobacteria,2JI5D@204432|Acidobacteriia	204432|Acidobacteriia	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6451777_66	102232.GLO73106DRAFT_00001230	1.511e-14	83.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1G1Y4@1117|Cyanobacteria	1117|Cyanobacteria	H	Uroporphyrinogen-III synthase	hemD	-	2.1.1.107,4.2.1.75	ko:K01719,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165,R03194	RC00003,RC00871,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iJN678.hemD	HEM4,TP_methylase
HKD1_k127_6451777_1	1179773.BN6_44150	7.361e-220	708.0	COG0474@1|root,COG0474@2|Bacteria,2GJJC@201174|Actinobacteria,4E15N@85010|Pseudonocardiales	201174|Actinobacteria	P	E1-E2 ATPase	ctpE	GO:0003674,GO:0003824,GO:0005215,GO:0005388,GO:0005575,GO:0005622,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006812,GO:0006816,GO:0008150,GO:0008324,GO:0015075,GO:0015085,GO:0015318,GO:0015399,GO:0015405,GO:0015662,GO:0016020,GO:0016021,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0019829,GO:0022804,GO:0022853,GO:0022857,GO:0022890,GO:0030001,GO:0031224,GO:0031226,GO:0034220,GO:0042623,GO:0042625,GO:0042626,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043492,GO:0044424,GO:0044425,GO:0044459,GO:0044464,GO:0046873,GO:0051179,GO:0051234,GO:0055085,GO:0070588,GO:0070838,GO:0071944,GO:0072511,GO:0090662,GO:0098655,GO:0098660,GO:0098662,GO:0099131,GO:0099132	-	ko:K12952	-	-	-	-	ko00000,ko01000	3.A.3.23	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_6451777_59	1267535.KB906767_gene623	7.973e-19	100.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_6451777_34	639282.DEFDS_1810	1.649e-69	241.0	COG2316@1|root,COG2316@2|Bacteria,2GFCZ@200930|Deferribacteres	200930|Deferribacteres	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_6451777_14	1144275.COCOR_07996	5.13e-117	384.0	COG0506@1|root,COG0506@2|Bacteria,1R8VR@1224|Proteobacteria,42P21@68525|delta/epsilon subdivisions,2WJU2@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Proline dehydrogenase	-	-	-	ko:K00318	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R10507	RC00083	ko00000,ko00001,ko01000	-	-	-	Pro_dh
HKD1_k127_6451777_61	1278073.MYSTI_03931	1.649e-17	88.0	COG1585@1|root,COG1585@2|Bacteria,1NG8Q@1224|Proteobacteria,42WTA@68525|delta/epsilon subdivisions,2WSVK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	OU	NfeD-like C-terminal, partner-binding	-	-	-	-	-	-	-	-	-	-	-	-	NfeD
HKD1_k127_6451777_35	861299.J421_2843	7.911e-65	232.0	COG0631@1|root,COG0631@2|Bacteria,1ZT1X@142182|Gemmatimonadetes	142182|Gemmatimonadetes	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C_2
HKD1_k127_6451777_7	240015.ACP_1006	1.312e-153	495.0	COG0626@1|root,COG0626@2|Bacteria,3Y2K5@57723|Acidobacteria,2JHVD@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	4.4.1.1,4.4.1.2,4.4.1.8	ko:K01760,ko:K17217	ko00260,ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00260,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017,M00609	R00782,R01001,R01283,R01286,R02408,R04941	RC00056,RC00069,RC00348,RC00382,RC00487,RC00488,RC00710,RC01245,RC02303,RC02814	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_6451777_9	1121957.ATVL01000009_gene1201	8.629e-152	489.0	COG2170@1|root,COG2170@2|Bacteria,4NFFP@976|Bacteroidetes,47KG2@768503|Cytophagia	976|Bacteroidetes	S	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity	ybdK	-	-	ko:K06048	-	-	-	-	ko00000,ko01000	-	-	-	GCS2
HKD1_k127_6451777_37	215803.DB30_2020	1.44e-62	232.0	COG3034@1|root,COG3034@2|Bacteria	2|Bacteria	M	peptidoglycan biosynthetic process	IV02_27405	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_6451777_42	1173024.KI912148_gene2698	2.258e-54	198.0	COG0122@1|root,COG0122@2|Bacteria,1G394@1117|Cyanobacteria,1JKIH@1189|Stigonemataceae	1117|Cyanobacteria	L	endonuclease III	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_6451777_70	706587.Desti_2768	3.046e-11	74.0	COG0518@1|root,COG0518@2|Bacteria	2|Bacteria	F	GMP synthase (glutamine-hydrolyzing) activity	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_6451777_11	316067.Geob_0475	3.109e-130	432.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,42P7Z@68525|delta/epsilon subdivisions,2WK06@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_6451777_67	1049564.TevJSym_aj00090	7.363e-14	79.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,1S8UU@1236|Gammaproteobacteria,1J6KV@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	CO	Thioredoxin-like	resA	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_6451777_4	1125863.JAFN01000001_gene2409	2.326e-157	512.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,42NGD@68525|delta/epsilon subdivisions,2WJDC@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	TIGRFAM proton-translocating NADH-quinone oxidoreductase, chain M	nuoM-1	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD1_k127_6451777_3	443144.GM21_3999	7.539e-182	593.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,42KZE@68525|delta/epsilon subdivisions,2WIPT@28221|Deltaproteobacteria,43TW3@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NADH-Ubiquinone oxidoreductase (complex I) chain 5 L domain protein	nuoL-1	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD1_k127_6451777_49	204669.Acid345_1306	1.363e-31	126.0	COG0713@1|root,COG0713@2|Bacteria,3Y4XI@57723|Acidobacteria,2JJIM@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_6451777_52	234267.Acid_0116	1.176e-27	120.0	COG0839@1|root,COG0839@2|Bacteria,3Y4I4@57723|Acidobacteria	57723|Acidobacteria	C	PFAM NADH-ubiquinone plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_6451777_16	1382359.JIAL01000001_gene2022	2.275e-110	367.0	COG1005@1|root,COG1005@2|Bacteria,3Y3VS@57723|Acidobacteria,2JHQZ@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_6451777_10	204669.Acid345_1309	5.644e-134	455.0	COG3383@1|root,COG3383@2|Bacteria,3Y2T6@57723|Acidobacteria,2JIAG@204432|Acidobacteriia	204432|Acidobacteriia	C	PFAM NADH ubiquinone oxidoreductase, subunit G, iron-sulphur binding	-	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Fer4,Fer4_10,Fer4_6,Molybdop_Fe4S4,Molybdopterin,NADH-G_4Fe-4S_3
HKD1_k127_6451777_5	1340493.JNIF01000003_gene1646	6.82e-156	503.0	COG1894@1|root,COG1894@2|Bacteria,3Y2NM@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD1_k127_6451777_41	653733.Selin_0887	5.462e-55	198.0	COG1905@1|root,COG1905@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	nuoE	-	1.6.5.3	ko:K00334,ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_6451777_71	1123392.AQWL01000001_gene1493	3.675e-09	60.0	2C51Y@1|root,33J3U@2|Bacteria,1P6QZ@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6451777_8	443143.GM18_4387	7.681e-152	490.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,42M9G@68525|delta/epsilon subdivisions,2WIS7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	GO:0003674,GO:0003824,GO:0003954,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005886,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016020,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0044424,GO:0044464,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0071944,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00333,ko:K13378,ko:K13380	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa,Complex1_49kDa,NiFeSe_Hases
HKD1_k127_6451777_45	1232410.KI421424_gene1782	2.065e-44	167.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,42NAR@68525|delta/epsilon subdivisions,2WQB1@28221|Deltaproteobacteria,43UPG@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD1_k127_6451777_33	1121377.KB906398_gene2617	1.114e-70	244.0	COG0377@1|root,COG0377@2|Bacteria,1WIVW@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_6451777_46	639030.JHVA01000001_gene765	5.839e-36	142.0	COG0838@1|root,COG0838@2|Bacteria,3Y4SD@57723|Acidobacteria,2JJ78@204432|Acidobacteriia	204432|Acidobacteriia	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD1_k127_6451777_68	903818.KI912269_gene353	1.53e-13	79.0	2ET40@1|root,33KN7@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6451777_62	1499686.BN1079_02095	1.335e-16	81.0	COG2104@1|root,COG2104@2|Bacteria,1NG8E@1224|Proteobacteria,1SGCU@1236|Gammaproteobacteria	1236|Gammaproteobacteria	H	thiamine biosynthesis protein ThiS	thiS	-	-	ko:K03154	ko04122,map04122	-	-	-	ko00000,ko00001	-	-	-	ThiS
HKD1_k127_6451777_19	234267.Acid_7731	2.334e-102	339.0	COG2022@1|root,COG2022@2|Bacteria	2|Bacteria	H	thiamine diphosphate biosynthetic process	thiG	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006772,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009110,GO:0009228,GO:0009987,GO:0017144,GO:0018130,GO:0019438,GO:0034641,GO:0042364,GO:0042723,GO:0042724,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046483,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HKD1_k127_6451777_58	1040987.AZUY01000041_gene178	5.242e-19	89.0	COG3360@1|root,COG3360@2|Bacteria,1N6YT@1224|Proteobacteria,2UFPQ@28211|Alphaproteobacteria,43M7Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Dodecin	-	-	-	ko:K09165	-	-	-	-	ko00000	-	-	-	Dodecin
HKD1_k127_6451777_63	1408813.AYMG01000015_gene5014	1.747e-16	85.0	COG2823@1|root,COG2823@2|Bacteria,4NUHM@976|Bacteroidetes,1ITPV@117747|Sphingobacteriia	976|Bacteroidetes	S	BON domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_6451777_50	929556.Solca_3051	1.101e-28	119.0	COG1652@1|root,COG1652@2|Bacteria,4NNRS@976|Bacteroidetes,1IUNJ@117747|Sphingobacteriia	976|Bacteroidetes	S	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_6451777_47	1321779.HMPREF1984_00058	6.903e-33	134.0	COG5403@1|root,COG5403@2|Bacteria,37B87@32066|Fusobacteria	32066|Fusobacteria	S	Bacterial protein of unknown function (DUF937)	-	-	-	-	-	-	-	-	-	-	-	-	DUF937
HKD1_k127_6451777_72	1120960.ATXG01000011_gene3616	1.059e-08	71.0	COG0737@1|root,COG2374@1|root,COG0737@2|Bacteria,COG2374@2|Bacteria,2GKC3@201174|Actinobacteria,4FK4R@85023|Microbacteriaceae	201174|Actinobacteria	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.5	ko:K01081	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Big_3_5,Exo_endo_phos,He_PIG,LTD,Metallophos,PKD
HKD1_k127_6451777_15	391612.CY0110_08276	1.933e-112	414.0	COG2304@1|root,COG3210@1|root,COG2304@2|Bacteria,COG3210@2|Bacteria	2|Bacteria	U	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,Calx-beta,DUF11,DUF4214,HemolysinCabind,SdrD_B,VWA,VWA_2
HKD1_k127_6451777_65	1144275.COCOR_01607	8.916e-15	91.0	COG3568@1|root,COG3568@2|Bacteria,1N2ZJ@1224|Proteobacteria,42WUR@68525|delta/epsilon subdivisions,2WSUA@28221|Deltaproteobacteria,2YUA6@29|Myxococcales	28221|Deltaproteobacteria	PQ	Endonuclease/Exonuclease/phosphatase family	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos,LTD
HKD1_k127_6451777_51	582515.KR51_00003400	3.082e-28	136.0	COG1404@1|root,COG2374@1|root,COG2931@1|root,COG5492@1|root,COG1404@2|Bacteria,COG2374@2|Bacteria,COG2931@2|Bacteria,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	nucH	-	-	ko:K07004	-	-	-	-	ko00000	-	-	-	Big_5,Calx-beta,Exo_endo_phos,HemolysinCabind,LTD
HKD1_k127_6451777_75	756067.MicvaDRAFT_3420	4.923e-07	65.0	COG0823@1|root,COG2931@1|root,COG0823@2|Bacteria,COG2931@2|Bacteria,1G554@1117|Cyanobacteria,1HF7I@1150|Oscillatoriales	1117|Cyanobacteria	QU	PFAM Haemolysin-type calcium-binding repeat	-	-	-	-	-	-	-	-	-	-	-	-	HemolysinCabind,PD40
HKD1_k127_6451777_21	237368.SCABRO_03561	3.917e-100	335.0	COG1090@1|root,COG1090@2|Bacteria,2IXEW@203682|Planctomycetes	203682|Planctomycetes	S	epimerase	-	-	-	ko:K07071	-	-	-	-	ko00000	-	-	-	DUF1731,Epimerase,Polyketide_cyc
HKD1_k127_6451777_22	448385.sce5711	4.562e-97	326.0	2A3AC@1|root,30RSD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6451777_43	290397.Adeh_0437	3.927e-52	202.0	COG2059@1|root,COG2059@2|Bacteria,1RB6A@1224|Proteobacteria,43B62@68525|delta/epsilon subdivisions,2X6JK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_6451777_0	379066.GAU_0558	5.67e-242	764.0	COG0646@1|root,COG0685@1|root,COG0646@2|Bacteria,COG0685@2|Bacteria,1ZT6C@142182|Gemmatimonadetes	142182|Gemmatimonadetes	H	Methylenetetrahydrofolate reductase	-	-	1.5.1.20,2.1.1.10	ko:K00297,ko:K00547	ko00270,ko00670,ko00720,ko01100,ko01110,ko01120,ko01200,ko01523,map00270,map00670,map00720,map01100,map01110,map01120,map01200,map01523	M00377	R00650,R01224,R07168	RC00003,RC00035,RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR,S-methyl_trans
HKD1_k127_6514358_8	1267533.KB906733_gene3481	1.109e-127	409.0	COG1024@1|root,COG1024@2|Bacteria	2|Bacteria	I	Enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_6514358_29	639030.JHVA01000001_gene3699	9.463e-21	92.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_6514358_15	1267535.KB906767_gene2014	2.158e-88	308.0	COG3850@1|root,COG5002@1|root,COG3850@2|Bacteria,COG5002@2|Bacteria,3Y97Y@57723|Acidobacteria,2JP4Q@204432|Acidobacteriia	204432|Acidobacteriia	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_6514358_20	1267535.KB906767_gene3270	4.008e-71	246.0	COG0745@1|root,COG0745@2|Bacteria,3Y4J9@57723|Acidobacteria,2JJD5@204432|Acidobacteriia	204432|Acidobacteriia	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07669	ko02020,map02020	M00460	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6514358_10	234267.Acid_3632	2.876e-125	410.0	COG3182@1|root,COG3182@2|Bacteria,3Y2R7@57723|Acidobacteria	57723|Acidobacteria	S	PepSY-associated TM region	-	-	-	-	-	-	-	-	-	-	-	-	PepSY_TM
HKD1_k127_6514358_4	1089550.ATTH01000001_gene1831	4.245e-140	476.0	COG0515@1|root,COG0515@2|Bacteria,4NPN9@976|Bacteroidetes,1FJI6@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	KLT	Protein tyrosine kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	NERD,Pkinase,TPR_12,TPR_8
HKD1_k127_6514358_22	234267.Acid_1127	2.432e-50	186.0	COG1595@1|root,COG1595@2|Bacteria,3Y589@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_6514358_17	1288963.ADIS_4778	1.94e-73	284.0	COG3209@1|root,COG3291@1|root,COG4733@1|root,COG3209@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NTHZ@976|Bacteroidetes	976|Bacteroidetes	M	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6514358_23	640081.Dsui_0729	4.561e-48	200.0	COG4625@1|root,COG4625@2|Bacteria,1QU2X@1224|Proteobacteria,2VHDJ@28216|Betaproteobacteria	28216|Betaproteobacteria	MU	TIGRFAM outer membrane autotransporter barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter,He_PIG,TIG
HKD1_k127_6514358_2	314345.SPV1_03058	3.71e-201	654.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria	1224|Proteobacteria	P	NhaP-type Na H and K H antiporters	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger,cNMP_binding
HKD1_k127_6514358_35	1250006.JHZZ01000001_gene3159	5.481e-06	56.0	COG1309@1|root,COG1309@2|Bacteria,4NEUA@976|Bacteroidetes,1HZEU@117743|Flavobacteriia,3VVYA@52959|Polaribacter	976|Bacteroidetes	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_6514358_13	682795.AciX8_3966	3.606e-96	330.0	COG0642@1|root,COG2205@2|Bacteria,3Y2W3@57723|Acidobacteria,2JIDP@204432|Acidobacteriia	204432|Acidobacteriia	T	Histidine kinase	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA
HKD1_k127_6514358_18	1267533.KB906735_gene4781	2.683e-72	250.0	COG0745@1|root,COG0745@2|Bacteria,3Y4R4@57723|Acidobacteria,2JJBD@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator, receiver	-	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6514358_1	204669.Acid345_0510	3.273e-272	850.0	COG2060@1|root,COG2060@2|Bacteria,3Y2YP@57723|Acidobacteria,2JIFM@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD1_k127_6514358_0	204669.Acid345_0511	0.0	1019.0	COG2216@1|root,COG2216@2|Bacteria,3Y302@57723|Acidobacteria,2JHQI@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_6514358_16	204669.Acid345_0512	4.191e-79	268.0	COG2156@1|root,COG2156@2|Bacteria,3Y49M@57723|Acidobacteria,2JJ0W@204432|Acidobacteriia	204432|Acidobacteriia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD1_k127_6514358_5	1267533.KB906735_gene4558	2.979e-137	447.0	COG0642@1|root,COG2205@2|Bacteria,3Y33Y@57723|Acidobacteria,2JHWF@204432|Acidobacteriia	204432|Acidobacteriia	T	Osmosensitive K channel His kinase sensor	-	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	KdpD,Usp
HKD1_k127_6514358_6	1303518.CCALI_01551	7.187e-133	445.0	COG5002@1|root,COG5002@2|Bacteria	2|Bacteria	T	protein histidine kinase activity	kinB	-	2.7.13.3	ko:K11383	ko02020,map02020	M00505	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	4HB_MCP_1,HAMP,HATPase_c,HisKA,KinB_sensor,PAS,PAS_4
HKD1_k127_6514358_28	1303518.CCALI_01550	4.456e-35	143.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Methyltransf_23,Response_reg
HKD1_k127_6514358_27	1303518.CCALI_01550	1.167e-39	158.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	-	-	-	ko:K02490	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Methyltransf_23,Response_reg
HKD1_k127_6514358_9	204669.Acid345_1052	3.422e-127	452.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6514358_24	234267.Acid_7677	3.646e-47	175.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_6514358_14	861299.J421_5995	4.025e-95	338.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	AAA_16,Abhydrolase_1,PD40,Trans_reg_C
HKD1_k127_6514358_3	234267.Acid_5749	5.547e-173	574.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_6514358_36	1321778.HMPREF1982_02612	3.095e-05	56.0	2EZXH@1|root,33T1S@2|Bacteria,1VRJK@1239|Firmicutes,24B4Z@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6514358_12	1183438.GKIL_1125	8.772e-106	367.0	COG4166@1|root,COG4166@2|Bacteria,1GR16@1117|Cyanobacteria	1117|Cyanobacteria	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_6514358_25	864051.BurJ1DRAFT_3461	2.713e-42	162.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4,Sigma70_r4_2
HKD1_k127_6514358_7	864051.BurJ1DRAFT_3463	9.7e-133	458.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1MWRF@1224|Proteobacteria,2WHQF@28216|Betaproteobacteria,1KM9W@119065|unclassified Burkholderiales	28216|Betaproteobacteria	S	CHAT domain	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HKD1_k127_6514358_21	864051.BurJ1DRAFT_3464	3.31e-67	257.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2VJCT@28216|Betaproteobacteria	28216|Betaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_6514358_31	886293.Sinac_2696	8.417e-19	102.0	COG3420@1|root,COG3420@2|Bacteria,2J2MQ@203682|Planctomycetes	203682|Planctomycetes	P	Calx-beta domain	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta
HKD1_k127_6514358_26	234267.Acid_7393	1.028e-40	158.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_6514358_19	204669.Acid345_2219	6.513e-72	254.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y9GC@57723|Acidobacteria,2JKTW@204432|Acidobacteriia	204432|Acidobacteriia	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD1_k127_6514358_30	234267.Acid_7572	1.526e-20	98.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_6518176_11	1168034.FH5T_19015	2.767e-127	431.0	COG0644@1|root,COG0644@2|Bacteria,4P040@976|Bacteroidetes	976|Bacteroidetes	C	oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_39	1121875.KB907548_gene1637	3.359e-25	122.0	COG0664@1|root,COG0664@2|Bacteria,4NRPE@976|Bacteroidetes	976|Bacteroidetes	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_6518176_4	204669.Acid345_2716	2.423e-157	533.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_6518176_46	880071.Fleli_1580	3.601e-10	61.0	COG1595@1|root,COG1595@2|Bacteria,4NSN4@976|Bacteroidetes,47RXQ@768503|Cytophagia	976|Bacteroidetes	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_6518176_42	1183438.GKIL_3942	1.596e-23	102.0	COG1595@1|root,COG1595@2|Bacteria	2|Bacteria	K	DNA-templated transcription, initiation	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_6518176_12	251221.35211863	5.242e-126	415.0	COG1944@1|root,COG1944@2|Bacteria,1G8FH@1117|Cyanobacteria	1117|Cyanobacteria	S	YcaO cyclodehydratase, ATP-ad Mg2+-binding	-	-	-	ko:K09136	-	-	-	-	ko00000,ko03009	-	-	-	YcaO
HKD1_k127_6518176_31	251221.35211862	4.186e-52	192.0	COG3482@1|root,COG3482@2|Bacteria,1GA9H@1117|Cyanobacteria	1117|Cyanobacteria	S	TfuA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TfuA
HKD1_k127_6518176_3	204669.Acid345_1052	3.873e-182	599.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6518176_2	1267534.KB906755_gene4470	1.368e-183	601.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria,3Y7SS@57723|Acidobacteria,2JMXC@204432|Acidobacteriia	204432|Acidobacteriia	KU	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Trans_reg_C
HKD1_k127_6518176_29	1173024.KI912149_gene5730	1.742e-54	202.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1G4J0@1117|Cyanobacteria	1117|Cyanobacteria	M	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8,Trypsin_2
HKD1_k127_6518176_44	1122179.KB890447_gene184	2.015e-14	89.0	COG1361@1|root,COG4447@1|root,COG1361@2|Bacteria,COG4447@2|Bacteria,4NEZQ@976|Bacteroidetes	976|Bacteroidetes	DZ	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_6518176_8	1173024.KI912149_gene6404	2.192e-136	481.0	COG1404@1|root,COG1404@2|Bacteria,1G2F0@1117|Cyanobacteria	1117|Cyanobacteria	O	PFAM Beta-propeller repeat	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HKD1_k127_6518176_0	1173028.ANKO01000124_gene2863	4.49e-238	773.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1G135@1117|Cyanobacteria,1H8D7@1150|Oscillatoriales	1117|Cyanobacteria	M	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	CHAT,TPR_10,TPR_12,TPR_7,TPR_8
HKD1_k127_6518176_13	290397.Adeh_3913	1.135e-125	421.0	COG3547@1|root,COG3547@2|Bacteria,1NN5F@1224|Proteobacteria,42X06@68525|delta/epsilon subdivisions,2WWJ3@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_16	713587.THITH_15155	2.775e-108	370.0	COG3547@1|root,COG3547@2|Bacteria,1NN5F@1224|Proteobacteria	1224|Proteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_19	660470.Theba_2269	3.846e-92	323.0	COG1234@1|root,COG1234@2|Bacteria	2|Bacteria	L	tRNA 3'-trailer cleavage	-	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2,Lactamase_B_4
HKD1_k127_6518176_27	192952.MM_2865	2.517e-57	220.0	arCOG05210@1|root,arCOG05210@2157|Archaea,2Y4FW@28890|Euryarchaeota,2NB4Z@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_41	468556.AQYG01000047_gene1529	5.582e-24	107.0	2DJ5J@1|root,32UCF@2|Bacteria,2II98@201174|Actinobacteria,4GE3P@85026|Gordoniaceae	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_33	754477.Q7C_1504	1.061e-46	174.0	COG1778@1|root,COG1778@2|Bacteria,1RH85@1224|Proteobacteria,1S6D0@1236|Gammaproteobacteria,460SA@72273|Thiotrichales	72273|Thiotrichales	S	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate	-	-	3.1.3.45	ko:K03270	ko00540,ko01100,map00540,map01100	M00063	R03350	RC00017	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Hydrolase_3
HKD1_k127_6518176_20	309799.DICTH_1435	1.337e-81	280.0	COG1691@1|root,COG1691@2|Bacteria	2|Bacteria	C	(AIR) carboxylase	cpmA	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD1_k127_6518176_21	246194.CHY_1281	7.828e-81	277.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,42FCT@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM PP-loop domain protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	NAD_synthase
HKD1_k127_6518176_50	1123242.JH636434_gene4961	0.000748	53.0	COG0457@1|root,COG3119@1|root,COG0457@2|Bacteria,COG3119@2|Bacteria,2J3IX@203682|Planctomycetes	203682|Planctomycetes	P	arylsulfatase A	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase,TPR_16,TPR_19,TPR_2
HKD1_k127_6518176_18	329726.AM1_2195	1.467e-97	327.0	COG2877@1|root,COG2877@2|Bacteria,1G2XI@1117|Cyanobacteria	1117|Cyanobacteria	M	Belongs to the KdsA family	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD1_k127_6518176_23	1242864.D187_010069	2.056e-72	263.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD1_k127_6518176_38	512565.AMIS_1610	9.055e-32	134.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,2GXGF@201174|Actinobacteria,4DINJ@85008|Micromonosporales	201174|Actinobacteria	M	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_6518176_10	1396141.BATP01000003_gene5228	6.103e-128	420.0	COG0451@1|root,COG0451@2|Bacteria,46XPQ@74201|Verrucomicrobia,2IWC3@203494|Verrucomicrobiae	203494|Verrucomicrobiae	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_7	1469607.KK073769_gene5614	4.681e-149	484.0	COG3119@1|root,COG3119@2|Bacteria,1G5IZ@1117|Cyanobacteria,1HJSU@1161|Nostocales	1117|Cyanobacteria	P	Sulfatase	-	-	3.1.6.6	ko:K01133	-	-	-	-	ko00000,ko01000	-	-	-	DUF4976,Sulfatase,Sulfatase_C
HKD1_k127_6518176_5	261292.Nit79A3_2693	2.647e-155	509.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2VKEE@28216|Betaproteobacteria,371XI@32003|Nitrosomonadales	28216|Betaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_37	871963.Desdi_2842	3.166e-34	143.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,24JDA@186801|Clostridia,2629Q@186807|Peptococcaceae	186801|Clostridia	M	PFAM Transglycosylase SLT domain	yjbJ	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD1_k127_6518176_17	1267535.KB906767_gene1445	2.028e-99	329.0	2CDZB@1|root,2ZBFS@2|Bacteria,3Y5HH@57723|Acidobacteria,2JM8W@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_49	682795.AciX8_0445	1.496e-05	57.0	28MS6@1|root,2ZB0K@2|Bacteria,3Y38I@57723|Acidobacteria,2JHU5@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_43	997346.HMPREF9374_3141	1.387e-19	103.0	COG0526@1|root,COG0526@2|Bacteria,1V1R4@1239|Firmicutes,4HFWU@91061|Bacilli,27BS4@186824|Thermoactinomycetaceae	91061|Bacilli	CO	Thioredoxin-like	ykuV	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_6518176_30	926561.KB900617_gene1293	1.704e-53	207.0	COG0515@1|root,COG2815@1|root,COG0515@2|Bacteria,COG2815@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,3WAHY@53433|Halanaerobiales	186801|Clostridia	T	Protein kinase domain	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_6518176_45	85962.C694_02945	1.741e-13	78.0	COG0586@1|root,COG0586@2|Bacteria,1R5SJ@1224|Proteobacteria,43AE6@68525|delta/epsilon subdivisions,2YT12@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_6518176_32	1121468.AUBR01000015_gene2260	6.011e-50	194.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,24862@186801|Clostridia,42FQR@68295|Thermoanaerobacterales	186801|Clostridia	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_6518176_35	589924.Ferp_0042	8.806e-46	184.0	COG1032@1|root,arCOG01356@2157|Archaea,2XU04@28890|Euryarchaeota,245XG@183980|Archaeoglobi	183980|Archaeoglobi	C	SMART Elongator protein 3 MiaB NifB	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_6518176_1	289376.THEYE_A0010	6.845e-214	678.0	COG0504@1|root,COG0504@2|Bacteria,3J0FB@40117|Nitrospirae	40117|Nitrospirae	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD1_k127_6518176_25	926692.AZYG01000040_gene1540	3.774e-66	235.0	COG1212@1|root,COG1212@2|Bacteria,1TQU3@1239|Firmicutes,24H2B@186801|Clostridia,3WAKF@53433|Halanaerobiales	186801|Clostridia	M	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria	kdsB	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD1_k127_6518176_24	661478.OP10G_1736	3.474e-68	243.0	COG2382@1|root,COG2382@2|Bacteria	2|Bacteria	P	enterobactin catabolic process	-	-	-	-	-	-	-	-	-	-	-	-	Esterase
HKD1_k127_6518176_15	383372.Rcas_1801	5.285e-109	368.0	COG2308@1|root,COG2308@2|Bacteria,2G7ZB@200795|Chloroflexi,3754D@32061|Chloroflexia	32061|Chloroflexia	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	CP_ATPgrasp_2
HKD1_k127_6518176_28	1254432.SCE1572_01530	4.164e-57	206.0	COG2353@1|root,COG2353@2|Bacteria,1R9XD@1224|Proteobacteria,42TDG@68525|delta/epsilon subdivisions,2WPJP@28221|Deltaproteobacteria,2Z1CP@29|Myxococcales	28221|Deltaproteobacteria	S	Belongs to the UPF0312 family	-	-	-	-	-	-	-	-	-	-	-	-	YceI
HKD1_k127_6518176_14	1183438.GKIL_2649	3.183e-111	373.0	COG3503@1|root,COG3503@2|Bacteria	2|Bacteria	J	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF1624,DUF418
HKD1_k127_6518176_6	1123371.ATXH01000018_gene1394	2.699e-154	505.0	COG0111@1|root,COG2150@1|root,COG0111@2|Bacteria,COG2150@2|Bacteria,2GH7H@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	E	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD1_k127_6518176_22	926550.CLDAP_21370	8.375e-76	266.0	COG0598@1|root,COG0598@2|Bacteria,2G6EQ@200795|Chloroflexi	200795|Chloroflexi	P	Mediates influx of magnesium ions	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD1_k127_6518176_40	1158338.JNLJ01000001_gene566	3.952e-25	113.0	COG1267@1|root,COG1267@2|Bacteria,2G497@200783|Aquificae	200783|Aquificae	I	PFAM Phosphatidylglycerophosphatase A	pgpA	-	3.1.3.27	ko:K01095	ko00564,ko01100,map00564,map01100	-	R02029	RC00017	ko00000,ko00001,ko01000	-	-	-	PgpA
HKD1_k127_6518176_9	278963.ATWD01000001_gene1650	1.616e-130	432.0	COG0621@1|root,COG0621@2|Bacteria,3Y362@57723|Acidobacteria,2JIYW@204432|Acidobacteriia	204432|Acidobacteriia	H	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,UPF0004
HKD1_k127_6518176_47	682795.AciX8_0750	2.288e-08	64.0	29833@1|root,2ZV92@2|Bacteria,3Y940@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6518176_26	1499967.BAYZ01000105_gene3510	7.603e-66	250.0	COG1305@1|root,COG1305@2|Bacteria	2|Bacteria	E	Transglutaminase-like superfamily	-	-	2.3.2.13	ko:K22452	-	-	-	-	ko00000,ko01000	-	-	-	DUF3488,DUF4129,Transglut_core
HKD1_k127_6518176_34	1120985.AUMI01000017_gene2729	1.414e-46	174.0	COG2930@1|root,COG2930@2|Bacteria,1VBSP@1239|Firmicutes,4H54G@909932|Negativicutes	909932|Negativicutes	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_6518176_36	1449345.JHWC01000019_gene1337	2.748e-38	144.0	2AU0F@1|root,31JKB@2|Bacteria,1RGGF@1224|Proteobacteria,42S33@68525|delta/epsilon subdivisions	1224|Proteobacteria	S	COG NOG14600 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_654031_3	1163617.SCD_n02152	2.321e-94	316.0	COG0500@1|root,COG2226@2|Bacteria,1MVXN@1224|Proteobacteria,2VQVG@28216|Betaproteobacteria	28216|Betaproteobacteria	Q	Methyltransferase type 11	arsM	-	2.1.1.137	ko:K07755	-	-	-	-	ko00000,ko01000	-	-	-	Methyltransf_31
HKD1_k127_654031_0	497964.CfE428DRAFT_2721	8.709e-239	749.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,46U7Q@74201|Verrucomicrobia	74201|Verrucomicrobia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	-	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD1_k127_654031_5	497964.CfE428DRAFT_5881	3.762e-55	207.0	COG4585@1|root,COG4585@2|Bacteria,46V1V@74201|Verrucomicrobia	74201|Verrucomicrobia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA_3
HKD1_k127_654031_4	1267533.KB906737_gene1728	1.189e-65	232.0	COG2197@1|root,COG2197@2|Bacteria	2|Bacteria	K	response regulator	-	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	GerE,Response_reg
HKD1_k127_654031_8	536019.Mesop_0803	3.282e-09	57.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,43HCJ@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_654031_7	1038860.AXAP01000042_gene59	4.475e-14	73.0	COG2133@1|root,COG2133@2|Bacteria,1MVK5@1224|Proteobacteria,2TRN9@28211|Alphaproteobacteria,3JU1E@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	G	Glucose / Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_654031_2	639030.JHVA01000001_gene2743	8.437e-152	487.0	COG1064@1|root,COG1064@2|Bacteria,3Y3X1@57723|Acidobacteria,2JJDF@204432|Acidobacteriia	204432|Acidobacteriia	C	Zinc-binding dehydrogenase	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_654031_9	518766.Rmar_0335	2.072e-05	49.0	2EH9H@1|root,30IPX@2|Bacteria,4PF9X@976|Bacteroidetes,1FKCD@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_654031_1	1463901.JOIY01000009_gene2707	2.271e-161	524.0	COG1233@1|root,COG1233@2|Bacteria,2GMUC@201174|Actinobacteria	201174|Actinobacteria	Q	oxidoreductase	-	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,DAO,NAD_binding_8
HKD1_k127_654031_6	1379270.AUXF01000006_gene150	1.553e-45	169.0	2DEWU@1|root,2ZPJP@2|Bacteria,1ZUFA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6643771_5	1396141.BATP01000026_gene1023	8.325e-46	171.0	COG1376@1|root,COG1376@2|Bacteria,46VEG@74201|Verrucomicrobia,2IVY0@203494|Verrucomicrobiae	203494|Verrucomicrobiae	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD1_k127_6643771_2	335543.Sfum_3682	3.932e-65	231.0	COG2930@1|root,COG2930@2|Bacteria,1RHV6@1224|Proteobacteria,42TN0@68525|delta/epsilon subdivisions,2WQ75@28221|Deltaproteobacteria,2MQM3@213462|Syntrophobacterales	28221|Deltaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_6643771_10	497964.CfE428DRAFT_6257	2.65e-21	97.0	2CDIR@1|root,348KT@2|Bacteria,46W4H@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6643771_4	497964.CfE428DRAFT_0566	4.991e-61	214.0	COG0590@1|root,COG0590@2|Bacteria,46SZZ@74201|Verrucomicrobia	74201|Verrucomicrobia	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD1_k127_6643771_0	1403819.BATR01000021_gene737	5e-324	1001.0	COG0365@1|root,COG0365@2|Bacteria,46SBX@74201|Verrucomicrobia,2ITZ8@203494|Verrucomicrobiae	203494|Verrucomicrobiae	I	Acetyl-coenzyme A synthetase N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_6643771_6	497964.CfE428DRAFT_4097	9.256e-40	159.0	COG2173@1|root,COG2173@2|Bacteria,46VUM@74201|Verrucomicrobia	74201|Verrucomicrobia	M	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide	-	-	3.4.13.22	ko:K08641	ko01502,ko02020,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	Peptidase_M15
HKD1_k127_6643771_7	1156937.MFUM_920020	9.853e-33	132.0	2AG58@1|root,3169Z@2|Bacteria,46WMP@74201|Verrucomicrobia,37GPD@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6643771_1	861299.J421_1133	1.956e-139	457.0	COG0531@1|root,COG0531@2|Bacteria	2|Bacteria	E	amino acid	gadC	GO:0003333,GO:0003674,GO:0005215,GO:0005342,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006820,GO:0006865,GO:0006873,GO:0006885,GO:0008150,GO:0008509,GO:0008514,GO:0009987,GO:0015075,GO:0015171,GO:0015179,GO:0015291,GO:0015297,GO:0015318,GO:0015711,GO:0015807,GO:0015849,GO:0016020,GO:0016021,GO:0019725,GO:0022804,GO:0022857,GO:0030003,GO:0030004,GO:0030641,GO:0031224,GO:0031226,GO:0034220,GO:0042592,GO:0044425,GO:0044459,GO:0044464,GO:0045852,GO:0046942,GO:0046943,GO:0048878,GO:0050801,GO:0051179,GO:0051234,GO:0051453,GO:0051454,GO:0055067,GO:0055080,GO:0055082,GO:0055085,GO:0065007,GO:0065008,GO:0071702,GO:0071705,GO:0071944,GO:0098656,GO:0098771,GO:1902475,GO:1903825,GO:1905039	-	ko:K20265	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000	2.A.3.7.1,2.A.3.7.3	-	iEC042_1314.EC042_1624	AA_permease_2
HKD1_k127_6643771_8	1403819.BATR01000021_gene748	1.205e-27	115.0	COG1324@1|root,COG1324@2|Bacteria,46TAD@74201|Verrucomicrobia,2IUTN@203494|Verrucomicrobiae	203494|Verrucomicrobiae	P	CutA1 divalent ion tolerance protein	-	-	-	-	-	-	-	-	-	-	-	-	CutA1
HKD1_k127_6643771_3	497964.CfE428DRAFT_4701	1.682e-63	223.0	COG0482@1|root,COG0482@2|Bacteria,46SQW@74201|Verrucomicrobia	74201|Verrucomicrobia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_6654798_13	156889.Mmc1_1411	2.552e-47	185.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	GO:0006355,GO:0006464,GO:0006807,GO:0006808,GO:0007154,GO:0007584,GO:0008150,GO:0008152,GO:0009605,GO:0009719,GO:0009889,GO:0009891,GO:0009893,GO:0009987,GO:0009991,GO:0010033,GO:0010243,GO:0010468,GO:0010556,GO:0010557,GO:0010604,GO:0010628,GO:0018175,GO:0018177,GO:0019219,GO:0019222,GO:0019538,GO:0031323,GO:0031325,GO:0031326,GO:0031328,GO:0031667,GO:0031668,GO:0031669,GO:0031670,GO:0036211,GO:0042221,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0045893,GO:0045935,GO:0048518,GO:0048522,GO:0050789,GO:0050794,GO:0050896,GO:0051171,GO:0051173,GO:0051252,GO:0051254,GO:0051716,GO:0060255,GO:0065007,GO:0070887,GO:0071310,GO:0071417,GO:0071495,GO:0071496,GO:0071704,GO:0080090,GO:0090293,GO:1901564,GO:1901698,GO:1901699,GO:1902680,GO:1903506,GO:1903508,GO:2000112,GO:2001141	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	ACT,GlnD_UR_UTase,GlnE,HD,NTP_transf_2
HKD1_k127_6654798_12	640511.BC1002_4772	4.492e-49	183.0	COG0526@1|root,COG0526@2|Bacteria,1RA5V@1224|Proteobacteria,2VQX7@28216|Betaproteobacteria,1KFIZ@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD1_k127_6654798_10	1125863.JAFN01000001_gene3571	1.719e-49	183.0	COG1595@1|root,COG1595@2|Bacteria,1RHKM@1224|Proteobacteria,43AXT@68525|delta/epsilon subdivisions,2X6BZ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6654798_21	1101195.Meth11DRAFT_2246	0.0003457	48.0	COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,2W81G@28216|Betaproteobacteria,2KNB0@206350|Nitrosomonadales	206350|Nitrosomonadales	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6654798_5	1254432.SCE1572_44415	1.938e-96	333.0	COG1404@1|root,COG1404@2|Bacteria,1PEJJ@1224|Proteobacteria,438RE@68525|delta/epsilon subdivisions,2X3YD@28221|Deltaproteobacteria,2YXKA@29|Myxococcales	28221|Deltaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_6654798_18	941824.TCEL_01381	6.872e-17	94.0	COG0296@1|root,COG0366@1|root,COG0296@2|Bacteria,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,247YM@186801|Clostridia,36EQD@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 13 family	-	-	-	-	-	-	-	-	-	-	-	-	AMPK1_CBM,Alpha-amylase,Alpha-amylase_N,Big_2,CBM_20,CBM_48,Cadherin-like,Malt_amylase_C,PUD,SLH
HKD1_k127_6654798_20	1472716.KBK24_0137515	0.000314	48.0	COG5660@1|root,COG5660@2|Bacteria,1NH4R@1224|Proteobacteria,2VXXB@28216|Betaproteobacteria,1K9C3@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6654798_6	251229.Chro_3613	8.555e-92	312.0	COG0580@1|root,COG0580@2|Bacteria,1G3MJ@1117|Cyanobacteria	1117|Cyanobacteria	U	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD1_k127_6654798_11	861299.J421_1881	3.027e-49	184.0	COG2931@1|root,COG2931@2|Bacteria	2|Bacteria	Q	calcium- and calmodulin-responsive adenylate cyclase activity	-	-	-	-	-	-	-	-	-	-	-	-	An_peroxidase,HemolysinCabind,PD40
HKD1_k127_6654798_3	861299.J421_1875	1.566e-104	347.0	COG0662@1|root,COG3193@1|root,COG0662@2|Bacteria,COG3193@2|Bacteria	2|Bacteria	G	Cupin 2, conserved barrel domain protein	-	-	-	ko:K11477	-	-	-	-	ko00000	-	-	-	Cupin_2,Haem_degrading
HKD1_k127_6654798_16	136993.KB900626_gene3353	5.659e-35	139.0	COG3193@1|root,COG3193@2|Bacteria,1RGUD@1224|Proteobacteria,2UGI0@28211|Alphaproteobacteria,371DY@31993|Methylocystaceae	28211|Alphaproteobacteria	S	Haem-degrading	-	-	-	-	-	-	-	-	-	-	-	-	Haem_degrading
HKD1_k127_6654798_1	861299.J421_1876	3.946e-189	608.0	COG3386@1|root,COG3386@2|Bacteria	2|Bacteria	G	gluconolactonase activity	-	-	3.1.1.17	ko:K01053	ko00030,ko00053,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,map00030,map00053,map00930,map01100,map01110,map01120,map01130,map01200,map01220	M00129	R01519,R02933,R03751	RC00537,RC00983	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	SGL
HKD1_k127_6654798_8	118168.MC7420_8161	1.847e-67	236.0	COG0572@1|root,COG0572@2|Bacteria,1G67K@1117|Cyanobacteria,1HC0C@1150|Oscillatoriales	1117|Cyanobacteria	F	uridine kinase	-	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HKD1_k127_6654798_4	1121939.L861_19245	3.311e-100	336.0	COG1893@1|root,COG1893@2|Bacteria,1MX5M@1224|Proteobacteria,1SZ0M@1236|Gammaproteobacteria,1XKZK@135619|Oceanospirillales	135619|Oceanospirillales	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_6654798_17	977880.RALTA_A0817	1.555e-20	100.0	COG2128@1|root,COG2128@2|Bacteria,1MUDM@1224|Proteobacteria,2VIMU@28216|Betaproteobacteria,1JZUC@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD1_k127_6654798_22	384765.SIAM614_09573	0.0004444	48.0	COG4994@1|root,COG4994@2|Bacteria,1N6US@1224|Proteobacteria,2UKX8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_6654798_19	240015.ACP_2670	1.511e-07	60.0	2DMNM@1|root,32SQ0@2|Bacteria,3Y56W@57723|Acidobacteria,2JJPJ@204432|Acidobacteriia	204432|Acidobacteriia	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6654798_14	682795.AciX8_3179	3.675e-45	180.0	COG1595@1|root,COG1595@2|Bacteria,3Y3BS@57723|Acidobacteria,2JIDF@204432|Acidobacteriia	204432|Acidobacteriia	K	RNA polymerase sigma factor	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6654798_15	497964.CfE428DRAFT_5990	1.706e-43	167.0	COG1595@1|root,COG1595@2|Bacteria,46W20@74201|Verrucomicrobia	74201|Verrucomicrobia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6654798_9	861299.J421_1880	7.899e-55	197.0	COG1672@1|root,COG1672@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DM13
HKD1_k127_6654798_0	861299.J421_1872	1.221e-268	833.0	COG2303@1|root,COG2303@2|Bacteria	2|Bacteria	E	choline dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,GMC_oxred_C,GMC_oxred_N
HKD1_k127_6654798_2	211165.AJLN01000061_gene3947	5.368e-145	468.0	COG0346@1|root,COG0346@2|Bacteria,1G29P@1117|Cyanobacteria,1JK2A@1189|Stigonemataceae	1117|Cyanobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD1_k127_6654798_7	118173.KB235914_gene2349	5.693e-87	290.0	COG0431@1|root,COG0431@2|Bacteria,1G3AZ@1117|Cyanobacteria,1HAU3@1150|Oscillatoriales	1117|Cyanobacteria	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_6694911_8	234267.Acid_3225	1.192e-98	346.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C
HKD1_k127_6694911_29	1499967.BAYZ01000105_gene3503	6.316e-09	68.0	COG3420@1|root,COG3420@2|Bacteria	2|Bacteria	P	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,DUF5011
HKD1_k127_6694911_24	1163409.UUA_10506	6.745e-18	89.0	2CH9S@1|root,2ZGJY@2|Bacteria,1P9NA@1224|Proteobacteria,1SUCK@1236|Gammaproteobacteria,1XBSP@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6694911_22	324602.Caur_0299	4.805e-22	111.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
HKD1_k127_6694911_25	323097.Nham_3856	1.08e-10	74.0	COG5295@1|root,COG5295@2|Bacteria	2|Bacteria	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Beta_helix,Haemagg_act
HKD1_k127_6694911_23	272134.KB731324_gene1448	1.17e-19	103.0	COG2133@1|root,COG2931@1|root,COG2133@2|Bacteria,COG2931@2|Bacteria,1G2CB@1117|Cyanobacteria	1117|Cyanobacteria	G	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,GSDH,PA14
HKD1_k127_6694911_13	234267.Acid_5219	3.833e-61	216.0	COG1595@1|root,COG1595@2|Bacteria,3Y7YB@57723|Acidobacteria	2|Bacteria	K	RNA polymerase, sigma-24 subunit, ECF subfamily	-	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_ECF
HKD1_k127_6694911_3	1267533.KB906735_gene4448	1.448e-204	674.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_17
HKD1_k127_6694911_7	1123278.KB893428_gene110	2.212e-122	400.0	COG0500@1|root,COG2226@2|Bacteria,4NFRD@976|Bacteroidetes,47MKY@768503|Cytophagia	976|Bacteroidetes	Q	Putative methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_6694911_6	1370121.AUWS01000033_gene4232	8.067e-152	494.0	COG0076@1|root,COG0076@2|Bacteria,2GK3J@201174|Actinobacteria,234CE@1762|Mycobacteriaceae	201174|Actinobacteria	E	decarboxylase	-	-	4.1.1.105,4.1.1.28	ko:K01593	ko00350,ko00360,ko00380,ko00901,ko00950,ko00965,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00350,map00360,map00380,map00901,map00950,map00965,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00037,M00042	R00685,R00699,R00736,R02080,R02701,R04909	RC00299	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyridoxal_deC
HKD1_k127_6694911_12	767817.Desgi_2852	3.048e-63	242.0	COG2114@1|root,COG4252@1|root,COG2114@2|Bacteria,COG4252@2|Bacteria,1UYB2@1239|Firmicutes,24AKI@186801|Clostridia,263E3@186807|Peptococcaceae	186801|Clostridia	T	CHASE2	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE2,Guanylate_cyc
HKD1_k127_6694911_5	1144275.COCOR_04551	1.378e-161	516.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,42MDR@68525|delta/epsilon subdivisions,2WKUR@28221|Deltaproteobacteria,2YXF2@29|Myxococcales	28221|Deltaproteobacteria	C	Aldo/keto reductase family	-	-	1.1.1.65	ko:K05275	ko00750,ko01100,ko01120,map00750,map01100,map01120	-	R01708	RC00116	ko00000,ko00001,ko01000	-	-	-	Aldo_ket_red
HKD1_k127_6694911_28	880073.Calab_1008	2.212e-09	66.0	COG4244@1|root,COG4244@2|Bacteria	2|Bacteria	E	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2231
HKD1_k127_6694911_14	118168.MC7420_553	1.674e-60	216.0	COG1592@1|root,COG1592@2|Bacteria,1G5YD@1117|Cyanobacteria,1HBFD@1150|Oscillatoriales	1117|Cyanobacteria	C	Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_6694911_16	1131462.DCF50_p2146	3.503e-34	147.0	COG0446@1|root,COG0446@2|Bacteria,1UC47@1239|Firmicutes,24NN7@186801|Clostridia,265QC@186807|Peptococcaceae	186801|Clostridia	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6694911_20	1296416.JACB01000001_gene3358	2.713e-25	112.0	COG0589@1|root,COG0589@2|Bacteria,4NJ0H@976|Bacteroidetes,1I0HV@117743|Flavobacteriia,2YKRI@290174|Aquimarina	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6694911_1	1267535.KB906767_gene2871	2.297e-308	966.0	COG0474@1|root,COG0474@2|Bacteria,3Y3ZX@57723|Acidobacteria,2JMFS@204432|Acidobacteriia	204432|Acidobacteriia	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.2	ko:K01531	-	-	-	-	ko00000,ko01000	3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_6694911_0	671143.DAMO_1138	0.0	1170.0	COG3383@1|root,COG3383@2|Bacteria,2NNQ6@2323|unclassified Bacteria	2|Bacteria	C	Molydopterin dinucleotide binding domain	fdxB	-	1.17.1.10,1.17.1.9	ko:K00123,ko:K05299	ko00630,ko00680,ko00720,ko01100,ko01120,ko01200,map00630,map00680,map00720,map01100,map01120,map01200	M00377	R00134,R00519	RC02796	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_4,Fer4,Fer4_10,Fer4_4,Fer4_6,Fer4_7,Molybdop_Fe4S4,Molybdopterin,Molydop_binding
HKD1_k127_6694911_11	518766.Rmar_1284	9.937e-76	262.0	COG1018@1|root,COG1018@2|Bacteria,4PEIX@976|Bacteroidetes,1FJ74@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	C	Oxidoreductase NAD-binding domain	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
HKD1_k127_6694911_30	1007104.SUS17_3147	8.166e-06	53.0	2DQCB@1|root,335WZ@2|Bacteria,1N06Y@1224|Proteobacteria,2UCE4@28211|Alphaproteobacteria,2KB5X@204457|Sphingomonadales	204457|Sphingomonadales	S	Family of unknown function (DUF5335)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5335
HKD1_k127_6694911_4	1173024.KI912151_gene2146	4.47e-201	636.0	COG2312@1|root,COG2312@2|Bacteria,1GA2Z@1117|Cyanobacteria,1JKPG@1189|Stigonemataceae	1117|Cyanobacteria	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	Erythro_esteras
HKD1_k127_6694911_10	118163.Ple7327_0398	4.063e-80	276.0	COG1926@1|root,COG1926@2|Bacteria,1G2IS@1117|Cyanobacteria,3VJI1@52604|Pleurocapsales	1117|Cyanobacteria	S	PFAM Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD1_k127_6694911_9	1173024.KI912148_gene3333	1.46e-80	274.0	COG0412@1|root,COG0412@2|Bacteria,1G1CY@1117|Cyanobacteria,1JJI9@1189|Stigonemataceae	1117|Cyanobacteria	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD1_k127_6694911_17	243231.GSU0260	1.265e-29	124.0	COG0589@1|root,COG0589@2|Bacteria	2|Bacteria	T	AMP binding	-	-	-	ko:K06149	-	-	-	-	ko00000	-	-	-	Usp
HKD1_k127_6694911_21	1265505.ATUG01000002_gene1885	9.756e-25	115.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2MJDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_6694911_18	1123392.AQWL01000007_gene1011	1.765e-26	116.0	COG1499@1|root,COG1499@2|Bacteria,1RD49@1224|Proteobacteria,2VRQB@28216|Betaproteobacteria,1KSJT@119069|Hydrogenophilales	119069|Hydrogenophilales	J	ribosomal large subunit export from nucleus	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6694911_26	1117647.M5M_11100	1.161e-10	71.0	2C852@1|root,32YB2@2|Bacteria,1N9HY@1224|Proteobacteria,1SCRT@1236|Gammaproteobacteria,1J6SR@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD1_k127_6694911_2	1040983.AXAE01000023_gene23	4.302e-241	756.0	COG0459@1|root,COG0459@2|Bacteria,1PMNK@1224|Proteobacteria,2TTPT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006457,GO:0006458,GO:0008150,GO:0009987,GO:0016465,GO:0032991,GO:0044183,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0051082,GO:0061077,GO:0101031,GO:1990220	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_6702024_0	1047013.AQSP01000108_gene2065	0.0	1251.0	COG0793@1|root,COG4946@1|root,COG0793@2|Bacteria,COG4946@2|Bacteria,2NQEH@2323|unclassified Bacteria	2|Bacteria	M	Tricorn protease C1 domain	-	-	-	ko:K08676	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S41,Tricorn_C1,Tricorn_PDZ
HKD1_k127_6702024_1	1163408.UU9_00874	5.548e-176	572.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,1SYR1@1236|Gammaproteobacteria,1XCSI@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_6702024_3	234267.Acid_2734	2.599e-64	251.0	COG1629@1|root,COG4771@2|Bacteria,3Y2WI@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug
HKD1_k127_6702024_2	309801.trd_1459	1.433e-89	308.0	COG0624@1|root,COG0624@2|Bacteria,2G60R@200795|Chloroflexi,27Y02@189775|Thermomicrobia	189775|Thermomicrobia	E	peptidase dimerisation domain protein	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_6754334_9	497964.CfE428DRAFT_3001	2.39e-29	138.0	COG1470@1|root,COG2911@1|root,COG2931@1|root,COG4412@1|root,COG4733@1|root,COG4932@1|root,COG1470@2|Bacteria,COG2911@2|Bacteria,COG2931@2|Bacteria,COG4412@2|Bacteria,COG4733@2|Bacteria,COG4932@2|Bacteria	2|Bacteria	M	domain protein	-	-	2.7.11.1,3.2.1.4	ko:K01179,ko:K12567,ko:K20276,ko:K21449	ko00500,ko01100,ko02024,ko05410,ko05414,map00500,map01100,map02024,map05410,map05414	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000,ko01001,ko02000,ko04131,ko04147,ko04812	1.B.40.2	GH5,GH9	-	DUF4347,HemolysinCabind,Peptidase_M30
HKD1_k127_6754334_2	204669.Acid345_1066	2.413e-76	292.0	COG1404@1|root,COG1409@1|root,COG3055@1|root,COG3291@1|root,COG3386@1|root,COG1404@2|Bacteria,COG1409@2|Bacteria,COG3055@2|Bacteria,COG3291@2|Bacteria,COG3386@2|Bacteria,3Y3S3@57723|Acidobacteria,2JMMV@204432|Acidobacteriia	204432|Acidobacteriia	GO	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	ASH
HKD1_k127_6754334_3	215803.DB30_4430	2.59e-56	206.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,42MB9@68525|delta/epsilon subdivisions,2WJ64@28221|Deltaproteobacteria,2YV5Q@29|Myxococcales	28221|Deltaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.304,1.1.1.47,1.1.1.76	ko:K00034,ko:K03366	ko00030,ko00650,ko01120,ko01200,map00030,map00650,map01120,map01200	-	R01520,R01521,R02855,R02946,R03707,R09078,R10505	RC00066,RC00205,RC00525	ko00000,ko00001,ko01000	-	-	-	adh_short,adh_short_C2
HKD1_k127_6754334_7	38727.Pavir.J03121.1.p	2.654e-31	137.0	COG0707@1|root,2QPXV@2759|Eukaryota,37P1J@33090|Viridiplantae,3G9N5@35493|Streptophyta,3KRPU@4447|Liliopsida,3I2U3@38820|Poales	35493|Streptophyta	M	Monogalactosyldiacylglycerol (MGDG) synthase	MGD1	GO:0000003,GO:0003006,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006629,GO:0006643,GO:0006664,GO:0006996,GO:0007275,GO:0008150,GO:0008152,GO:0008194,GO:0008378,GO:0008610,GO:0009058,GO:0009247,GO:0009507,GO:0009526,GO:0009528,GO:0009536,GO:0009657,GO:0009668,GO:0009706,GO:0009790,GO:0009791,GO:0009793,GO:0009941,GO:0009987,GO:0010027,GO:0010154,GO:0016020,GO:0016043,GO:0016740,GO:0016757,GO:0016758,GO:0019866,GO:0022414,GO:0031090,GO:0031967,GO:0031969,GO:0031975,GO:0032501,GO:0032502,GO:0035250,GO:0042170,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044422,GO:0044424,GO:0044434,GO:0044435,GO:0044444,GO:0044446,GO:0044464,GO:0046467,GO:0046509,GO:0048316,GO:0048608,GO:0048731,GO:0048856,GO:0061024,GO:0061458,GO:0071704,GO:0071840,GO:1901135,GO:1901137,GO:1901576,GO:1903509	2.4.1.46	ko:K03715	ko00561,ko01100,map00561,map01100	-	R02691	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,MGDG_synth
HKD1_k127_6754334_5	1122921.KB898201_gene3195	5.172e-38	158.0	COG0535@1|root,COG0535@2|Bacteria,1UXWS@1239|Firmicutes	1239|Firmicutes	C	Radical SAM	-	-	-	ko:K22227	-	-	-	-	ko00000	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD1_k127_6754334_0	1340493.JNIF01000003_gene2599	1.173e-159	514.0	COG2204@1|root,COG2204@2|Bacteria,3Y2J1@57723|Acidobacteria	57723|Acidobacteria	T	two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_6754334_1	204669.Acid345_1393	9.883e-114	395.0	COG5000@1|root,COG5000@2|Bacteria,3Y32D@57723|Acidobacteria,2JIN2@204432|Acidobacteriia	204432|Acidobacteriia	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA,PAS_4,PAS_8
HKD1_k127_6754334_8	240015.ACP_2463	2.299e-30	134.0	COG1266@1|root,COG1266@2|Bacteria,3Y4ED@57723|Acidobacteria,2JJ3Q@204432|Acidobacteriia	204432|Acidobacteriia	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD1_k127_6754334_4	234267.Acid_5135	3.625e-48	182.0	COG1595@1|root,COG1595@2|Bacteria,3Y7Z3@57723|Acidobacteria	57723|Acidobacteria	K	Sigma-70 region 2	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6754334_6	1267535.KB906767_gene3332	7.831e-36	143.0	2DKN8@1|root,32UFB@2|Bacteria,3Y55I@57723|Acidobacteria,2JJU7@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4252
HKD1_k127_6754334_12	234267.Acid_3707	0.0002804	50.0	2EGKM@1|root,33ACV@2|Bacteria,3Y5U1@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6754334_10	278963.ATWD01000002_gene808	4.849e-05	55.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_6867708_49	1123013.AUIC01000003_gene346	7.792e-15	87.0	COG5305@1|root,COG5305@2|Bacteria,2GN7C@201174|Actinobacteria,4FKGE@85023|Microbacteriaceae	201174|Actinobacteria	S	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	ko:K14340	-	-	-	-	ko00000,ko01000,ko01003	-	-	-	PMT_2
HKD1_k127_6867708_25	1267533.KB906738_gene2211	5.407e-64	246.0	COG0457@1|root,COG0741@1|root,COG0457@2|Bacteria,COG0741@2|Bacteria,3Y2UJ@57723|Acidobacteria,2JIUE@204432|Acidobacteriia	204432|Acidobacteriia	M	Transglycosylase SLT domain	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT,TPR_16,YfiO
HKD1_k127_6867708_9	204669.Acid345_1052	3.767e-150	505.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_6867708_48	383372.Rcas_2697	3.02e-19	94.0	COG1595@1|root,COG1595@2|Bacteria,2G99U@200795|Chloroflexi	200795|Chloroflexi	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6867708_58	1112212.JH584235_gene3414	2.176e-05	55.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,2K9XH@204457|Sphingomonadales	204457|Sphingomonadales	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6867708_47	391008.Smal_2940	2.673e-19	99.0	COG3595@1|root,COG3595@2|Bacteria,1P19T@1224|Proteobacteria,1RRSR@1236|Gammaproteobacteria,1X62K@135614|Xanthomonadales	135614|Xanthomonadales	S	Putative adhesin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4097
HKD1_k127_6867708_28	204669.Acid345_1037	1.77e-61	223.0	COG3595@1|root,COG3595@2|Bacteria,3Y97I@57723|Acidobacteria,2JNRB@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6867708_60	1266909.AUAG01000004_gene2097	5.265e-05	51.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,1WWQ4@135613|Chromatiales	135613|Chromatiales	K	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_6867708_3	1379698.RBG1_1C00001G0054	4.367e-203	638.0	COG2502@1|root,COG2502@2|Bacteria,2NNKP@2323|unclassified Bacteria	2|Bacteria	E	Aspartate-ammonia ligase	asnA	GO:0003674,GO:0003824,GO:0004071,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006528,GO:0006529,GO:0006807,GO:0006950,GO:0006974,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009987,GO:0016053,GO:0016211,GO:0016874,GO:0016879,GO:0016880,GO:0019752,GO:0032787,GO:0033554,GO:0034641,GO:0042802,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0050896,GO:0051716,GO:0071704,GO:0072330,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	6.3.1.1	ko:K01914	ko00250,ko00460,ko01100,ko01110,ko01230,map00250,map00460,map01100,map01110,map01230	-	R00483	RC00010	ko00000,ko00001,ko01000	-	-	iAPECO1_1312.APECO1_2719,iECOK1_1307.ECOK1_4193,iECS88_1305.ECS88_4166,iUMN146_1321.UM146_18910,iUTI89_1310.UTI89_C4299	AsnA
HKD1_k127_6867708_56	1169143.KB911049_gene5579	6.732e-06	54.0	COG2207@1|root,COG2207@2|Bacteria,1MY46@1224|Proteobacteria,2W1XW@28216|Betaproteobacteria,1KFVM@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD1_k127_6867708_42	204669.Acid345_2058	2.944e-24	117.0	COG2304@1|root,COG2304@2|Bacteria,3Y38P@57723|Acidobacteria,2JIRN@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_6867708_6	204669.Acid345_2024	3.27e-182	584.0	COG1807@1|root,COG1807@2|Bacteria,3Y383@57723|Acidobacteria,2JIBE@204432|Acidobacteriia	204432|Acidobacteriia	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_6867708_17	1173029.JH980292_gene563	1.747e-112	374.0	COG3288@1|root,COG3288@2|Bacteria,1G1D1@1117|Cyanobacteria,1H7A5@1150|Oscillatoriales	1117|Cyanobacteria	C	NAD NADP transhydrogenase alpha subunit	pntA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N,PNTB_4TM
HKD1_k127_6867708_39	671143.DAMO_0094	2.471e-30	123.0	COG3288@1|root,COG3288@2|Bacteria,2NRJW@2323|unclassified Bacteria	2|Bacteria	C	4TM region of pyridine nucleotide transhydrogenase, mitoch	pntA-2	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD1_k127_6867708_10	861299.J421_0514	1.238e-149	486.0	COG1282@1|root,COG1282@2|Bacteria,1ZUT8@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	-	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD1_k127_6867708_11	661478.OP10G_2288	3.019e-146	482.0	COG2234@1|root,COG2234@2|Bacteria	2|Bacteria	DZ	aminopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,PA,Peptidase_M28
HKD1_k127_6867708_32	1121396.KB893062_gene2736	6.639e-43	161.0	COG3118@1|root,COG3118@2|Bacteria,1RHUA@1224|Proteobacteria,42S1N@68525|delta/epsilon subdivisions,2WNUH@28221|Deltaproteobacteria,2MJVE@213118|Desulfobacterales	28221|Deltaproteobacteria	O	TIGRFAM thioredoxin	trx-3	-	1.8.1.8	ko:K03672	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Thioredoxin
HKD1_k127_6867708_30	246197.MXAN_6883	4.31e-46	174.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,42S9C@68525|delta/epsilon subdivisions,2WM4G@28221|Deltaproteobacteria,2YXFQ@29|Myxococcales	28221|Deltaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD1_k127_6867708_23	204669.Acid345_2640	2.902e-71	259.0	COG0400@1|root,COG0400@2|Bacteria	2|Bacteria	S	palmitoyl-(protein) hydrolase activity	-	-	-	ko:K06999	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Abhydrolase_2,Abhydrolase_4,Esterase
HKD1_k127_6867708_7	414684.RC1_3136	2.447e-164	535.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2JRAY@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_6867708_40	1340493.JNIF01000003_gene2460	6.067e-27	124.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria	57723|Acidobacteria	S	PFAM von Willebrand factor type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_6867708_33	1121918.ARWE01000001_gene3484	2.218e-42	174.0	COG4399@1|root,COG4399@2|Bacteria,1R42C@1224|Proteobacteria,42Q2W@68525|delta/epsilon subdivisions,2WJIA@28221|Deltaproteobacteria,43S0C@69541|Desulfuromonadales	28221|Deltaproteobacteria	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD1_k127_6867708_38	575540.Isop_1522	2.254e-32	128.0	COG1146@1|root,COG1146@2|Bacteria,2J013@203682|Planctomycetes	203682|Planctomycetes	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
HKD1_k127_6867708_44	1267535.KB906767_gene1432	8.205e-23	98.0	COG2835@1|root,COG2835@2|Bacteria,3Y8VE@57723|Acidobacteria	57723|Acidobacteria	S	Trm112p-like protein	-	-	-	ko:K09791	-	-	-	-	ko00000	-	-	-	Trm112p
HKD1_k127_6867708_37	234267.Acid_2356	5.971e-33	142.0	COG0859@1|root,COG0859@2|Bacteria,3Y616@57723|Acidobacteria	57723|Acidobacteria	M	Glycosyltransferase family 9 (heptosyltransferase)	-	-	-	ko:K02849	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT9	-	Glyco_transf_9
HKD1_k127_6867708_22	330214.NIDE2553	7.229e-81	280.0	COG2870@1|root,COG2870@2|Bacteria,3J0GT@40117|Nitrospirae	40117|Nitrospirae	M	Phosphomethylpyrimidine kinase	-	-	2.7.1.167,2.7.7.70	ko:K03272	ko00540,ko01100,map00540,map01100	M00064	R05644,R05646	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	PfkB
HKD1_k127_6867708_21	1070319.CAGGBEG34_190038	2.155e-87	309.0	COG2027@1|root,COG2027@2|Bacteria,1MW40@1224|Proteobacteria,2VH20@28216|Betaproteobacteria,1JZWN@119060|Burkholderiaceae	28216|Betaproteobacteria	M	D-alanyl-d-alanine carboxypeptidase	dacB	-	3.4.16.4	ko:K07259	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	Peptidase_S13
HKD1_k127_6867708_57	1267533.KB906733_gene3585	1.116e-05	54.0	COG2318@1|root,COG2318@2|Bacteria,3Y569@57723|Acidobacteria,2JMW6@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_6867708_26	913865.DOT_4964	5.505e-64	230.0	COG0253@1|root,COG0253@2|Bacteria,1TPMN@1239|Firmicutes,24AGY@186801|Clostridia,260JZ@186807|Peptococcaceae	186801|Clostridia	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD1_k127_6867708_31	479434.Sthe_1246	1.89e-45	181.0	COG0515@1|root,COG1520@1|root,COG0515@2|Bacteria,COG1520@2|Bacteria,2G5NM@200795|Chloroflexi,27Z13@189775|Thermomicrobia	189775|Thermomicrobia	KLT	PQQ-like domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PQQ_3,Pkinase
HKD1_k127_6867708_43	589924.Ferp_0806	6.601e-24	109.0	COG0518@1|root,arCOG00087@2157|Archaea,2XT3G@28890|Euryarchaeota,2465P@183980|Archaeoglobi	183980|Archaeoglobi	F	Catalyzes the synthesis of GMP from XMP	guaAA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_6867708_20	1303518.CCALI_02738	1.255e-88	296.0	COG0066@1|root,COG0066@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuD	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_6867708_1	1303518.CCALI_02739	2.668e-223	699.0	COG0065@1|root,COG0065@2|Bacteria	2|Bacteria	E	3-isopropylmalate dehydratase activity	leuC	GO:0003674,GO:0003824,GO:0003861,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006551,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009081,GO:0009082,GO:0009098,GO:0009316,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0016853,GO:0016866,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044445,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607,GO:1902494	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iEcE24377_1341.EcE24377A_0075,iPC815.YPO0531,iSB619.SA_RS10700	Aconitase
HKD1_k127_6867708_16	760568.Desku_2885	4.138e-118	390.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,260XK@186807|Peptococcaceae	186801|Clostridia	CE	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_6867708_8	1121920.AUAU01000037_gene2735	8.457e-157	503.0	COG0119@1|root,COG0119@2|Bacteria,3Y2WT@57723|Acidobacteria	57723|Acidobacteria	E	Belongs to the alpha-IPM synthase homocitrate synthase family	-	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like
HKD1_k127_6867708_19	1198114.AciX9_2754	1.174e-102	342.0	COG0583@1|root,COG0583@2|Bacteria,3Y31P@57723|Acidobacteria,2JIC0@204432|Acidobacteriia	204432|Acidobacteriia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_6867708_18	671143.DAMO_2942	8.056e-108	370.0	COG2812@1|root,COG2812@2|Bacteria,2NNK7@2323|unclassified Bacteria	2|Bacteria	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD1_k127_6867708_52	32057.KB217478_gene6082	4.075e-10	70.0	28K7X@1|root,2Z9VW@2|Bacteria,1G4E1@1117|Cyanobacteria,1HK48@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6867708_54	118168.MC7420_6432	4.516e-08	64.0	28K7X@1|root,2Z9VW@2|Bacteria,1G4E1@1117|Cyanobacteria,1HBX1@1150|Oscillatoriales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6867708_34	521674.Plim_3619	5.054e-42	160.0	COG0590@1|root,COG0590@2|Bacteria,2IZCA@203682|Planctomycetes	203682|Planctomycetes	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD1_k127_6867708_27	316274.Haur_4101	1.174e-62	229.0	COG5530@1|root,COG5530@2|Bacteria	2|Bacteria	S	Predicted integral membrane protein (DUF2270)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2270
HKD1_k127_6867708_4	1382359.JIAL01000001_gene2082	1.812e-196	623.0	COG2986@1|root,COG2986@2|Bacteria,3Y3YW@57723|Acidobacteria,2JIK6@204432|Acidobacteriia	204432|Acidobacteriia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_6867708_45	401053.AciPR4_3988	3.601e-22	107.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_6867708_2	861299.J421_0912	4.419e-205	660.0	COG3664@1|root,COG3664@2|Bacteria	2|Bacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	F5_F8_type_C
HKD1_k127_6867708_15	861299.J421_2353	2.947e-120	408.0	COG5267@1|root,COG5267@2|Bacteria,1ZSPP@142182|Gemmatimonadetes	142182|Gemmatimonadetes	S	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HKD1_k127_6867708_0	204669.Acid345_1048	9.752e-270	839.0	COG2987@1|root,COG2987@2|Bacteria,3Y2VD@57723|Acidobacteria,2JK4Z@204432|Acidobacteriia	204432|Acidobacteriia	E	Urocanase Rossmann-like domain	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD1_k127_6867708_12	33876.JNXY01000005_gene8605	2.852e-143	467.0	COG0477@1|root,COG2814@2|Bacteria,2I2IS@201174|Actinobacteria,4DCIJ@85008|Micromonosporales	201174|Actinobacteria	EGP	Transmembrane secretion effector	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD1_k127_6867708_29	861299.J421_1513	3.6e-51	190.0	2CWY1@1|root,32T0M@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6867708_13	1379270.AUXF01000005_gene474	1.292e-134	454.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSZA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_6867708_24	1120973.AQXL01000068_gene19	1.548e-65	233.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,4HB73@91061|Bacilli,2788T@186823|Alicyclobacillaceae	91061|Bacilli	I	Enoyl-CoA hydratase/isomerase	fadB	GO:0003674,GO:0003824,GO:0004300,GO:0006082,GO:0006629,GO:0006631,GO:0006635,GO:0008150,GO:0008152,GO:0009056,GO:0009062,GO:0009987,GO:0016042,GO:0016054,GO:0016829,GO:0016835,GO:0016836,GO:0019395,GO:0019752,GO:0030258,GO:0032787,GO:0034440,GO:0043436,GO:0044237,GO:0044238,GO:0044242,GO:0044248,GO:0044255,GO:0044281,GO:0044282,GO:0046395,GO:0055114,GO:0071704,GO:0072329,GO:1901575	4.2.1.17	ko:K01715,ko:K13767	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R03026,R04170,R04738,R04740,R04744,R04746	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_6867708_41	1502852.FG94_00507	8.213e-25	110.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria	1224|Proteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HKD1_k127_6867708_14	404589.Anae109_2774	5.567e-124	406.0	COG0604@1|root,COG0604@2|Bacteria,1MXUX@1224|Proteobacteria,42UGV@68525|delta/epsilon subdivisions,2WR1G@28221|Deltaproteobacteria,2YUDE@29|Myxococcales	28221|Deltaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_6867708_53	180281.CPCC7001_1234	2.535e-08	55.0	2EG5G@1|root,339XD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6867708_5	401053.AciPR4_0237	2.811e-188	603.0	COG3653@1|root,COG3653@2|Bacteria,3Y3Q2@57723|Acidobacteria,2JJ0K@204432|Acidobacteriia	204432|Acidobacteriia	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD1_k127_6867708_35	234267.Acid_1736	3.893e-39	149.0	COG1695@1|root,COG1695@2|Bacteria,3Y5FM@57723|Acidobacteria	57723|Acidobacteria	K	PFAM transcriptional regulator PadR family protein	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD1_k127_6867708_55	215803.DB30_7235	3.205e-06	56.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,433ZM@68525|delta/epsilon subdivisions,2X48T@28221|Deltaproteobacteria,2YYI5@29|Myxococcales	1224|Proteobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_6985075_7	641112.ACOK01000093_gene1122	0.0001491	49.0	2C9UW@1|root,2ZHW2@2|Bacteria,1W3WU@1239|Firmicutes,256VE@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6985075_0	326427.Cagg_2527	6.269e-166	536.0	COG0318@1|root,COG0318@2|Bacteria,2G83V@200795|Chloroflexi,376U1@32061|Chloroflexia	32061|Chloroflexia	IQ	AMP-dependent synthetase and ligase	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_6985075_2	1089544.KB912942_gene2511	9.907e-109	361.0	COG1893@1|root,COG1893@2|Bacteria,2GP6K@201174|Actinobacteria	201174|Actinobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	apbA	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_6985075_3	1101192.KB910516_gene3442	4.627e-105	356.0	COG2271@1|root,COG2271@2|Bacteria,1QW8U@1224|Proteobacteria,2TWTA@28211|Alphaproteobacteria,1JZIH@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08177	-	-	-	-	ko00000,ko02000	2.A.1.11	-	-	MFS_1
HKD1_k127_6985075_1	404589.Anae109_2957	4.998e-138	449.0	COG0075@1|root,COG0075@2|Bacteria,1MWHJ@1224|Proteobacteria,42MBH@68525|delta/epsilon subdivisions,2WK79@28221|Deltaproteobacteria,2YV9G@29|Myxococcales	28221|Deltaproteobacteria	H	aminotransferase	-	-	2.6.1.44,2.6.1.45,2.6.1.51	ko:K00830	ko00250,ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko04146,map00250,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map04146	M00346,M00532	R00369,R00372,R00585,R00588	RC00006,RC00008,RC00018	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD1_k127_6985075_4	234267.Acid_7098	3.056e-71	244.0	COG0503@1|root,COG0503@2|Bacteria,3Y30R@57723|Acidobacteria	57723|Acidobacteria	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD1_k127_6985075_5	639030.JHVA01000001_gene1597	1.491e-33	150.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria,2JHJT@204432|Acidobacteriia	204432|Acidobacteriia	S	TIGRFAM VWFA-related Acidobacterial domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7060801_3	1279009.ADICEAN_02097	6.089e-48	199.0	COG0823@1|root,COG1649@1|root,COG2931@1|root,COG3055@1|root,COG3210@1|root,COG4733@1|root,COG0823@2|Bacteria,COG1649@2|Bacteria,COG2931@2|Bacteria,COG3055@2|Bacteria,COG3210@2|Bacteria,COG4733@2|Bacteria,4NPRK@976|Bacteroidetes	976|Bacteroidetes	U	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7060801_5	234267.Acid_3219	2.192e-46	194.0	COG4447@1|root,COG4447@2|Bacteria,3Y4R8@57723|Acidobacteria	57723|Acidobacteria	O	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7060801_1	646529.Desaci_0135	7.883e-101	334.0	COG0479@1|root,COG0479@2|Bacteria,1TP17@1239|Firmicutes,24AN0@186801|Clostridia,262XA@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_17,Fer4_8
HKD1_k127_7060801_0	562970.Btus_0636	1.247e-273	852.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,4HBVG@91061|Bacilli,277ZQ@186823|Alicyclobacillaceae	91061|Bacilli	C	SdhA B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC D which are the membrane components and form cytochrome b556	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_7060801_4	292459.STH3176	3.803e-47	179.0	COG2009@1|root,COG2009@2|Bacteria,1TQUI@1239|Firmicutes,24M03@186801|Clostridia	186801|Clostridia	C	TIGRFAM succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family	-	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD1_k127_7060801_8	234267.Acid_0471	3.112e-27	113.0	COG1193@1|root,COG1193@2|Bacteria,3Y8PZ@57723|Acidobacteria	57723|Acidobacteria	L	Smr domain	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD1_k127_7060801_2	118166.JH976537_gene4467	6.962e-52	191.0	COG0279@1|root,COG0279@2|Bacteria,1G1I9@1117|Cyanobacteria,1HDBA@1150|Oscillatoriales	1117|Cyanobacteria	G	SIS domain	gmhA	-	5.3.1.28	ko:K03271	ko00540,ko01100,map00540,map01100	M00064	R05645,R09768,R09769	RC00434	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Glyco_transf_4,Glycos_transf_1,SIS_2
HKD1_k127_7060801_7	880072.Desac_0884	7.05e-28	127.0	COG0582@1|root,COG0582@2|Bacteria,1MWBN@1224|Proteobacteria	1224|Proteobacteria	L	Belongs to the 'phage' integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Arm-DNA-bind_4,Phage_int_SAM_3,Phage_integrase
HKD1_k127_7060801_11	1469607.KK073768_gene4767	5.931e-09	61.0	COG3744@1|root,COG3744@2|Bacteria,1G9VS@1117|Cyanobacteria,1HQ0Y@1161|Nostocales	1117|Cyanobacteria	S	PFAM PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD1_k127_7060801_9	240015.ACP_0451	1.439e-19	93.0	COG2963@1|root,COG2963@2|Bacteria,3Y92H@57723|Acidobacteria	57723|Acidobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD1_k127_7060801_6	1267535.KB906767_gene870	2.065e-39	172.0	COG3209@1|root,COG3209@2|Bacteria,3Y7FC@57723|Acidobacteria,2JKK9@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_7060801_10	926560.KE387023_gene3391	2.646e-17	96.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_7060801_12	1201288.M900_2187	1.287e-08	68.0	COG3210@1|root,COG5295@1|root,COG3210@2|Bacteria,COG5295@2|Bacteria,1N0C9@1224|Proteobacteria	1224|Proteobacteria	UW	YadA-like membrane anchor domain	-	-	-	ko:K12342	ko03070,map03070	-	-	-	ko00000,ko00001,ko02044	1.B.40.1.3,1.B.40.1.4	-	-	YadA_anchor,YadA_stalk
HKD1_k127_7071354_1	1278073.MYSTI_06568	4.57e-107	366.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,430H1@68525|delta/epsilon subdivisions,2WVZX@28221|Deltaproteobacteria,2YUWZ@29|Myxococcales	28221|Deltaproteobacteria	L	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,NUDIX
HKD1_k127_7071354_2	530564.Psta_0515	1.326e-84	286.0	COG2041@1|root,COG2041@2|Bacteria,2IYS5@203682|Planctomycetes	203682|Planctomycetes	S	Oxidoreductase, molybdopterin	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_molyb
HKD1_k127_7071354_4	311402.Avi_5607	2.266e-12	74.0	COG0664@1|root,COG0664@2|Bacteria,1RI6M@1224|Proteobacteria,2U9WH@28211|Alphaproteobacteria,4B9V7@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD1_k127_7071354_3	1499967.BAYZ01000118_gene3252	6.454e-46	168.0	COG0662@1|root,COG0662@2|Bacteria,2NRIV@2323|unclassified Bacteria	2|Bacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7071354_0	1519464.HY22_04445	4.101e-259	817.0	COG1770@1|root,COG1770@2|Bacteria,1FDQZ@1090|Chlorobi	1090|Chlorobi	E	PFAM peptidase S9 prolyl oligopeptidase active site domain protein	-	-	3.4.21.26,3.4.21.83	ko:K01322,ko:K01354	ko04614,ko05142,ko05143,map04614,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD1_k127_7071354_5	588932.JHOF01000017_gene2484	1.598e-10	64.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,2KH13@204458|Caulobacterales	204458|Caulobacterales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HKD1_k127_7081475_1	1403819.BATR01000009_gene303	9.889e-39	160.0	COG2067@1|root,COG2067@2|Bacteria	2|Bacteria	I	long-chain fatty acid transporting porin activity	-	-	-	ko:K06076	-	-	-	-	ko00000,ko02000	1.B.9	-	-	Phenol_MetA_deg
HKD1_k127_7081475_5	481448.Minf_0369	5.316e-08	64.0	COG3637@1|root,COG3637@2|Bacteria,46Z1R@74201|Verrucomicrobia,37H2D@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7081475_4	1396418.BATQ01000106_gene5302	1.788e-18	89.0	COG4566@1|root,COG4566@2|Bacteria,46Z3N@74201|Verrucomicrobia,2IW9Z@203494|Verrucomicrobiae	203494|Verrucomicrobiae	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_7081475_3	1278073.MYSTI_04028	1.521e-20	96.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,43AI7@68525|delta/epsilon subdivisions,2X5YF@28221|Deltaproteobacteria	28221|Deltaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7081475_0	497964.CfE428DRAFT_4403	7.478e-59	212.0	COG4566@1|root,COG4566@2|Bacteria,46V65@74201|Verrucomicrobia	74201|Verrucomicrobia	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7081475_2	395965.Msil_2683	1.239e-36	143.0	COG3829@1|root,COG4191@1|root,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3NAFU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9
HKD1_k127_708508_6	1304878.AUGD01000005_gene3577	1.743e-172	554.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,3JV7U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	GvpD gas vesicle protein	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HKD1_k127_708508_18	246197.MXAN_2785	8.154e-89	314.0	COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG5002@2|Bacteria,1NC9X@1224|Proteobacteria,43BU6@68525|delta/epsilon subdivisions,2X75B@28221|Deltaproteobacteria,2YWUB@29|Myxococcales	28221|Deltaproteobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HKD1_k127_708508_21	1379270.AUXF01000001_gene2153	1.922e-45	173.0	2BS4J@1|root,32M5G@2|Bacteria,1ZUJX@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_708508_22	279010.BL03345	1.143e-38	152.0	COG0741@1|root,COG0741@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1ZH33@1386|Bacillus	91061|Bacilli	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	yjbJ	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD1_k127_708508_20	234267.Acid_1366	6.854e-84	284.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqC	-	1.3.3.11	ko:K06137,ko:K06138	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM,TENA_THI-4
HKD1_k127_708508_9	1185876.BN8_04243	2.436e-158	510.0	COG1680@1|root,COG1680@2|Bacteria,4NHJN@976|Bacteroidetes,47JBV@768503|Cytophagia	976|Bacteroidetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_708508_25	414996.IL38_11170	4.335e-11	68.0	COG2197@1|root,COG2197@2|Bacteria,2GK4B@201174|Actinobacteria,408EN@622450|Actinopolysporales	201174|Actinobacteria	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_708508_0	204669.Acid345_0515	0.0	1354.0	COG4447@1|root,COG4447@2|Bacteria,3Y487@57723|Acidobacteria	57723|Acidobacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_708508_24	204669.Acid345_0263	8.838e-24	103.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_708508_19	1086011.HJ01_02304	1.269e-88	308.0	COG1434@1|root,COG1434@2|Bacteria,4NI1W@976|Bacteroidetes,1I1JS@117743|Flavobacteriia,2NYRV@237|Flavobacterium	976|Bacteroidetes	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_708508_14	880073.Calab_2889	1.813e-132	449.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NQIQ@2323|unclassified Bacteria	2|Bacteria	E	X-Pro dipeptidyl-peptidase (S15 family)	dpp	-	3.4.14.5	ko:K01278	ko04974,map04974	-	-	-	ko00000,ko00001,ko01000,ko01002,ko04090,ko04147	-	-	-	DPPIV_N,Peptidase_S9
HKD1_k127_708508_26	234267.Acid_7572	2.142e-09	59.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_708508_11	204669.Acid345_2716	1.893e-148	506.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_708508_15	204669.Acid345_1052	2.793e-110	377.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_708508_10	234267.Acid_5749	1.557e-151	511.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_708508_7	204669.Acid345_2716	7.104e-172	574.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_708508_17	1379698.RBG1_1C00001G0607	2.42e-94	331.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_708508_12	204669.Acid345_1052	1.425e-133	446.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_708508_5	1267534.KB906760_gene1549	6.743e-176	584.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_708508_28	204669.Acid345_4390	5.356e-07	55.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y69R@57723|Acidobacteria,2JKIQ@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_708508_4	1267534.KB906760_gene1549	6.362e-190	625.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_708508_1	1267534.KB906760_gene1549	2.319e-225	728.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y6A7@57723|Acidobacteria	57723|Acidobacteria	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_708508_3	1267533.KB906733_gene3215	2.359e-198	649.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria,2JM7T@204432|Acidobacteriia	204432|Acidobacteriia	KLTU	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase
HKD1_k127_708508_2	234267.Acid_7636	3.726e-204	664.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y333@57723|Acidobacteria	57723|Acidobacteria	KLTU	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Pkinase
HKD1_k127_708508_8	204669.Acid345_2716	5.476e-168	561.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_708508_23	41875.XP_007511676.1	1.18e-24	115.0	28M8C@1|root,2S5PV@2759|Eukaryota	2759|Eukaryota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_708508_27	661478.OP10G_2725	3.315e-09	61.0	COG1943@1|root,COG1943@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_708508_16	1267535.KB906767_gene1253	9.465e-95	320.0	COG1801@1|root,COG1801@2|Bacteria	2|Bacteria	L	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD1_k127_708508_13	246197.MXAN_6050	2.456e-133	432.0	COG0457@1|root,COG0457@2|Bacteria,1Q3YA@1224|Proteobacteria,437VH@68525|delta/epsilon subdivisions,2X354@28221|Deltaproteobacteria,2YUAY@29|Myxococcales	28221|Deltaproteobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
HKD1_k127_7201187_0	700598.Niako_2565	1.292e-198	623.0	COG3185@1|root,COG3185@2|Bacteria,4NFI7@976|Bacteroidetes,1IPBI@117747|Sphingobacteriia	976|Bacteroidetes	E	4-hydroxyphenylpyruvate dioxygenase	hppD	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HKD1_k127_7201187_2	876269.ARWA01000001_gene2872	1.035e-136	455.0	COG1502@1|root,COG1502@2|Bacteria,1R9CI@1224|Proteobacteria,2U350@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD1_k127_7201187_4	1267535.KB906767_gene4240	1.25e-75	269.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,Trans_reg_C
HKD1_k127_7201187_5	234267.Acid_7851	1.163e-66	236.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,3Y6UN@57723|Acidobacteria	57723|Acidobacteria	K	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7201187_3	1192124.LIG30_2014	5.176e-99	333.0	COG4874@1|root,COG4874@2|Bacteria,1N05R@1224|Proteobacteria,2VPEZ@28216|Betaproteobacteria,1K4CE@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD1_k127_7201187_1	497964.CfE428DRAFT_4535	7.898e-153	491.0	COG0205@1|root,COG0205@2|Bacteria,46SFN@74201|Verrucomicrobia	74201|Verrucomicrobia	G	Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions	pfkA	-	2.7.1.11,2.7.1.90	ko:K21071	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130	-	R00756,R00764,R02073,R03236,R04779	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PFK
HKD1_k127_7218395_26	706587.Desti_0054	1.25e-08	61.0	COG1314@1|root,COG1314@2|Bacteria,1NJ1D@1224|Proteobacteria,42TKW@68525|delta/epsilon subdivisions,2WRA3@28221|Deltaproteobacteria,2MS60@213462|Syntrophobacterales	28221|Deltaproteobacteria	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD1_k127_7218395_10	338966.Ppro_1695	1.823e-82	283.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,42MIF@68525|delta/epsilon subdivisions,2WIQF@28221|Deltaproteobacteria,43T81@69541|Desulfuromonadales	28221|Deltaproteobacteria	F	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD1_k127_7218395_4	292459.STH242	1.027e-133	437.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_7218395_2	204669.Acid345_2541	2.375e-149	478.0	COG0057@1|root,COG0057@2|Bacteria,3Y2QC@57723|Acidobacteria,2JI8H@204432|Acidobacteriia	204432|Acidobacteriia	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_7218395_23	278963.ATWD01000002_gene371	2.836e-28	131.0	COG1538@1|root,COG1538@2|Bacteria,3Y2NZ@57723|Acidobacteria,2JI75@204432|Acidobacteriia	204432|Acidobacteriia	MU	Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_7218395_19	1267535.KB906767_gene2285	1.11e-54	201.0	COG0463@1|root,COG0463@2|Bacteria,3Y34G@57723|Acidobacteria,2JIGQ@204432|Acidobacteriia	204432|Acidobacteriia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_7218395_9	234267.Acid_0099	3.946e-89	307.0	2EBMM@1|root,335MT@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7218395_17	1304885.AUEY01000032_gene2006	6.92e-59	216.0	COG1989@1|root,COG1989@2|Bacteria,1MUZF@1224|Proteobacteria,42S2A@68525|delta/epsilon subdivisions,2WMQ8@28221|Deltaproteobacteria,2MJAD@213118|Desulfobacterales	28221|Deltaproteobacteria	NOU	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue	pilD	-	3.4.23.43	ko:K02654	-	M00331	-	-	ko00000,ko00002,ko01000,ko01002,ko02035,ko02044	3.A.15.2	-	-	DiS_P_DiS,Peptidase_A24
HKD1_k127_7218395_16	204669.Acid345_1590	3.973e-62	231.0	COG4191@1|root,COG4191@2|Bacteria,3Y3X4@57723|Acidobacteria,2JING@204432|Acidobacteriia	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K02668,ko:K07708	ko02020,map02020	M00497,M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9,Response_reg,RsbRD_N
HKD1_k127_7218395_11	1121015.N789_09575	3.744e-68	243.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,1RZ45@1236|Gammaproteobacteria,1X6Z0@135614|Xanthomonadales	135614|Xanthomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_7218395_0	477974.Daud_0168	4.893e-241	757.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,261BW@186807|Peptococcaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_7218395_3	1183438.GKIL_3768	2.851e-136	451.0	COG0612@1|root,COG0612@2|Bacteria,1G303@1117|Cyanobacteria	1117|Cyanobacteria	S	PFAM Peptidase M16 inactive domain	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_7218395_1	1234364.AMSF01000025_gene3728	4.541e-152	495.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,1RN05@1236|Gammaproteobacteria,1X5E6@135614|Xanthomonadales	135614|Xanthomonadales	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_7218395_28	671143.DAMO_2924	3.141e-06	53.0	2CBGA@1|root,33A66@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7218395_6	1303518.CCALI_00143	7.87e-115	389.0	COG3664@1|root,COG3664@2|Bacteria	2|Bacteria	G	PFAM glycoside hydrolase family 39	-	-	-	-	-	-	-	-	-	-	-	-	Cellulase,Glyco_hydro_39,Glyco_hydro_42
HKD1_k127_7218395_13	32057.KB217478_gene1994	4.368e-66	234.0	COG2091@1|root,COG2091@2|Bacteria,1G5GA@1117|Cyanobacteria,1HNDC@1161|Nostocales	1117|Cyanobacteria	H	Belongs to the P-Pant transferase superfamily	-	-	-	ko:K06133	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD1_k127_7218395_5	1198114.AciX9_4589	8.012e-125	411.0	COG0438@1|root,COG0438@2|Bacteria,3Y2F3@57723|Acidobacteria,2JIQ3@204432|Acidobacteriia	204432|Acidobacteriia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_7218395_25	404589.Anae109_4438	1.849e-11	76.0	COG2244@1|root,COG2244@2|Bacteria,1NGCY@1224|Proteobacteria	1224|Proteobacteria	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_7218395_7	113395.AXAI01000001_gene3354	2.621e-97	332.0	COG0438@1|root,COG0438@2|Bacteria,1NE3V@1224|Proteobacteria,2U33D@28211|Alphaproteobacteria,3JVSE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyltransferase Family 4	-	-	-	ko:K02844	ko00540,ko01100,map00540,map01100	M00080	-	-	ko00000,ko00001,ko00002,ko01000,ko01003,ko01005	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_7218395_21	1173027.Mic7113_0108	4.269e-43	173.0	COG0438@1|root,COG0438@2|Bacteria,1G0CV@1117|Cyanobacteria,1H756@1150|Oscillatoriales	1117|Cyanobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_7218395_24	1192124.LIG30_0020	6.418e-25	120.0	COG3307@1|root,COG3307@2|Bacteria,1NVAA@1224|Proteobacteria	1224|Proteobacteria	M	-O-antigen	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7218395_18	1187851.A33M_0669	1.855e-57	213.0	COG5653@1|root,COG5653@2|Bacteria	2|Bacteria	M	Protein involved in cellulose biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6,FemAB
HKD1_k127_7218395_15	926550.CLDAP_04560	3.579e-63	231.0	COG0438@1|root,COG0438@2|Bacteria,2G5QJ@200795|Chloroflexi	200795|Chloroflexi	M	PFAM glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_7218395_22	1158292.JPOE01000005_gene810	1.541e-30	131.0	COG0726@1|root,COG0726@2|Bacteria,1MWR2@1224|Proteobacteria,2VWGV@28216|Betaproteobacteria,1KPKT@119065|unclassified Burkholderiales	28216|Betaproteobacteria	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_7218395_14	1121920.AUAU01000006_gene350	1.787e-64	231.0	2ART5@1|root,31H4G@2|Bacteria,3Y848@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7218395_8	290397.Adeh_2455	8.252e-96	331.0	COG1086@1|root,COG2148@1|root,COG1086@2|Bacteria,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,42MZY@68525|delta/epsilon subdivisions,2WJWT@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf,CoA_binding_3
HKD1_k127_7218395_20	1198114.AciX9_4582	1.545e-49	185.0	COG1596@1|root,COG1596@2|Bacteria,3Y591@57723|Acidobacteria,2JJVE@204432|Acidobacteriia	204432|Acidobacteriia	M	Polysaccharide biosynthesis/export protein	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD1_k127_7218395_27	690850.Desaf_0737	3.724e-08	63.0	COG0489@1|root,COG0489@2|Bacteria,1MYGS@1224|Proteobacteria,42T04@68525|delta/epsilon subdivisions,2WP72@28221|Deltaproteobacteria	28221|Deltaproteobacteria	D	protein tyrosine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	CBP_BcsQ
HKD1_k127_7218395_12	1267535.KB906767_gene2403	5.749e-67	248.0	COG3206@1|root,COG3206@2|Bacteria,3Y4H3@57723|Acidobacteria,2JJ3W@204432|Acidobacteriia	204432|Acidobacteriia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	Wzz
HKD1_k127_7237569_10	1408473.JHXO01000004_gene27	2.832e-105	348.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,2FMCU@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolase family 3	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HKD1_k127_7237569_9	204669.Acid345_3249	3.388e-160	518.0	COG1501@1|root,COG1501@2|Bacteria,3Y994@57723|Acidobacteria,2JIHI@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha galactosidase A	-	-	-	-	-	-	-	-	-	-	-	-	Melibiase_2
HKD1_k127_7237569_6	886293.Sinac_2104	1.011e-179	576.0	COG1680@1|root,COG1680@2|Bacteria,2IWSV@203682|Planctomycetes	203682|Planctomycetes	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD1_k127_7237569_0	661478.OP10G_1197	0.0	1034.0	COG1501@1|root,COG1501@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_7237569_1	204669.Acid345_0753	5.837e-281	870.0	COG3534@1|root,COG3534@2|Bacteria,3Y2ZG@57723|Acidobacteria,2JKB9@204432|Acidobacteriia	204432|Acidobacteriia	G	Alpha-L-arabinofuranosidase C-terminal domain	-	-	3.2.1.55	ko:K01209	ko00520,map00520	-	R01762	-	ko00000,ko00001,ko01000	-	GH51	-	Alpha-L-AF_C
HKD1_k127_7237569_5	1408473.JHXO01000002_gene3836	9.962e-185	598.0	COG3664@1|root,COG3664@2|Bacteria,4NHQ0@976|Bacteroidetes,2FQ9R@200643|Bacteroidia	976|Bacteroidetes	G	Glycosyl hydrolases family 39	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_39
HKD1_k127_7237569_3	485918.Cpin_6735	6.23e-216	679.0	COG5520@1|root,COG5520@2|Bacteria,4NF4C@976|Bacteroidetes,1INPD@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 30 family	-	-	3.2.1.45	ko:K01201	ko00511,ko00600,ko01100,ko04142,map00511,map00600,map01100,map04142	-	R01498	RC00059,RC00451	ko00000,ko00001,ko01000	-	GH30	-	Glyco_hydro_30,Glyco_hydro_30C
HKD1_k127_7237569_4	1267534.KB906754_gene3614	3.596e-197	638.0	COG0457@1|root,COG0457@2|Bacteria,3Y2Q7@57723|Acidobacteria,2JIH1@204432|Acidobacteriia	204432|Acidobacteriia	C	Cytochrome c554 and c-prime	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_C554,TPR_11,TPR_16,TPR_2,TPR_8
HKD1_k127_7237569_2	1267533.KB906733_gene3250	8.283e-218	694.0	COG0457@1|root,COG0457@2|Bacteria,3Y3VT@57723|Acidobacteria,2JHXZ@204432|Acidobacteriia	204432|Acidobacteriia	S	ASPIC and UnbV	-	-	-	-	-	-	-	-	-	-	-	-	UnbV_ASPIC,VCBS
HKD1_k127_7237569_13	1267535.KB906767_gene3520	4.698e-91	304.0	COG1136@1|root,COG1136@2|Bacteria,3Y4A6@57723|Acidobacteria,2JMVQ@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7237569_12	234267.Acid_1656	1.499e-91	317.0	COG0845@1|root,COG0845@2|Bacteria,3Y50Z@57723|Acidobacteria	57723|Acidobacteria	M	Biotin-lipoyl like	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD1_k127_7237569_11	1340493.JNIF01000003_gene2503	7.337e-93	317.0	COG0577@1|root,COG0577@2|Bacteria,3Y4C7@57723|Acidobacteria	57723|Acidobacteria	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7237569_15	1267535.KB906767_gene3517	1.796e-69	249.0	COG0577@1|root,COG0577@2|Bacteria,3Y4MY@57723|Acidobacteria,2JMXU@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7237569_7	1303518.CCALI_01151	4.903e-178	565.0	COG2115@1|root,COG2115@2|Bacteria	2|Bacteria	G	xylose isomerase activity	xylA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005996,GO:0008150,GO:0008152,GO:0009045,GO:0009056,GO:0016052,GO:0016853,GO:0016860,GO:0016861,GO:0019321,GO:0019323,GO:0042732,GO:0042843,GO:0044238,GO:0044281,GO:0044282,GO:0044424,GO:0044464,GO:0046365,GO:0071704,GO:1901575	5.3.1.5	ko:K01805	ko00040,ko00051,ko01100,map00040,map00051,map01100	-	R00878,R01432	RC00376,RC00516	ko00000,ko00001,ko01000	-	-	-	AP_endonuc_2
HKD1_k127_7237569_8	234267.Acid_2681	1.982e-163	535.0	COG3693@1|root,COG3693@2|Bacteria,3Y6EW@57723|Acidobacteria	57723|Acidobacteria	G	Glycosyl hydrolase family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_10
HKD1_k127_7237569_14	861299.J421_4525	2.667e-90	321.0	COG2755@1|root,COG2755@2|Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Cadherin,Cellulase,Lipase_GDSL_2,PA14,RicinB_lectin_2
HKD1_k127_7237569_16	861299.J421_4512	3.243e-07	53.0	COG2211@1|root,COG2211@2|Bacteria,1ZV78@142182|Gemmatimonadetes	142182|Gemmatimonadetes	G	MFS/sugar transport protein	-	-	-	ko:K03292	-	-	-	-	ko00000	2.A.2	-	-	MFS_2
HKD1_k127_7275947_1	452637.Oter_1442	4.371e-176	564.0	COG0737@1|root,COG0737@2|Bacteria,46VVX@74201|Verrucomicrobia	74201|Verrucomicrobia	F	5'-nucleotidase, C-terminal domain	-	-	3.1.3.6,3.1.4.16	ko:K01119	ko00230,ko00240,map00230,map00240	-	R01562,R01877,R02148,R02370,R03537,R03538,R03929,R05135	RC00078,RC00296	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,Metallophos
HKD1_k127_7275947_6	378806.STAUR_6496	9.868e-05	55.0	COG1807@1|root,COG1807@2|Bacteria,1Q30N@1224|Proteobacteria,438QE@68525|delta/epsilon subdivisions,2X906@28221|Deltaproteobacteria,2YXHX@29|Myxococcales	28221|Deltaproteobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT_2
HKD1_k127_7275947_5	671143.DAMO_2614	1.062e-12	79.0	COG0392@1|root,COG0392@2|Bacteria	2|Bacteria	M	lysyltransferase activity	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD1_k127_7275947_2	204669.Acid345_1131	2.125e-175	557.0	COG1960@1|root,COG1960@2|Bacteria,3Y32R@57723|Acidobacteria,2JIRM@204432|Acidobacteriia	204432|Acidobacteriia	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.1,1.3.99.12	ko:K00248,ko:K09478	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_7275947_4	42256.RradSPS_0416	4.534e-15	79.0	COG4783@1|root,COG4783@2|Bacteria	2|Bacteria	L	chaperone-mediated protein folding	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD1_k127_7275947_0	379066.GAU_2797	1.486e-302	945.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1ZT89@142182|Gemmatimonadetes	142182|Gemmatimonadetes	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD1_k127_7275947_3	886293.Sinac_1812	2.471e-66	234.0	COG4430@1|root,COG4430@2|Bacteria,2J0DY@203682|Planctomycetes	203682|Planctomycetes	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	OmdA
HKD1_k127_7301832_21	118161.KB235922_gene5902	2.376e-15	88.0	COG2133@1|root,COG2373@1|root,COG2133@2|Bacteria,COG2373@2|Bacteria,1G2CB@1117|Cyanobacteria,3VM5E@52604|Pleurocapsales	1117|Cyanobacteria	GQ	Glucose Sorbosone dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Calx-beta,DUF4347,GSDH,PA14
HKD1_k127_7301832_25	1270193.JARP01000002_gene633	0.000577	52.0	COG0018@1|root,COG5164@1|root,COG5295@1|root,COG0018@2|Bacteria,COG5164@2|Bacteria,COG5295@2|Bacteria,4NF3S@976|Bacteroidetes,1IKUQ@117743|Flavobacteriia,2NXWT@237|Flavobacterium	976|Bacteroidetes	UW	Collagen triple helix repeat (20 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen,Peptidase_S74
HKD1_k127_7301832_18	324602.Caur_0299	4.978e-22	111.0	COG5295@1|root,COG5295@2|Bacteria,2GB82@200795|Chloroflexi,377IZ@32061|Chloroflexia	32061|Chloroflexia	UW	Hep Hag repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Pectinesterase
HKD1_k127_7301832_2	316274.Haur_0966	2.11e-155	542.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	LTD,PKD,Reprolysin_4,Reprolysin_5
HKD1_k127_7301832_23	1038866.KB902829_gene1782	1.832e-09	72.0	COG1749@1|root,COG2133@1|root,COG3209@1|root,COG1749@2|Bacteria,COG2133@2|Bacteria,COG3209@2|Bacteria,1PF7U@1224|Proteobacteria,2V8VD@28211|Alphaproteobacteria,3K3RC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GN	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Calx-beta,DUF4082,GSDH
HKD1_k127_7301832_20	326427.Cagg_1151	4.606e-18	86.0	COG0425@1|root,COG0425@2|Bacteria,2G7DF@200795|Chloroflexi,377DX@32061|Chloroflexia	32061|Chloroflexia	O	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	TusA
HKD1_k127_7301832_10	1341151.ASZU01000014_gene2149	1.426e-93	324.0	COG0491@1|root,COG0607@1|root,COG0491@2|Bacteria,COG0607@2|Bacteria,1TPE2@1239|Firmicutes,4H9WH@91061|Bacilli,27B4H@186824|Thermoactinomycetaceae	91061|Bacilli	P	Rhodanese Homology Domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_7301832_15	926550.CLDAP_30490	4.379e-50	185.0	COG2210@1|root,COG2210@2|Bacteria,2G77F@200795|Chloroflexi	200795|Chloroflexi	S	DsrE/DsrF/DrsH-like family	-	-	-	-	-	-	-	-	-	-	-	-	DrsE_2
HKD1_k127_7301832_11	296591.Bpro_2639	6.964e-93	318.0	COG1917@1|root,COG1917@2|Bacteria,1RH0Y@1224|Proteobacteria,2VWWA@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7301832_7	713587.THITH_08540	1.066e-116	385.0	COG0702@1|root,COG0702@2|Bacteria,1N12V@1224|Proteobacteria,1S93R@1236|Gammaproteobacteria	1236|Gammaproteobacteria	GM	NmrA-like family	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD1_k127_7301832_16	604354.TSIB_1211	4.192e-46	177.0	arCOG09492@1|root,arCOG09492@2157|Archaea,2Y3AH@28890|Euryarchaeota,244X9@183968|Thermococci	183968|Thermococci	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7301832_4	204669.Acid345_2716	4.77e-148	503.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria	2|Bacteria	U	Involved in the tonB-independent uptake of proteins	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PD40,Pkinase,WD40
HKD1_k127_7301832_5	204669.Acid345_1052	4.488e-142	480.0	COG0457@1|root,COG0515@1|root,COG5616@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,COG5616@2|Bacteria,3Y2HR@57723|Acidobacteria,2JI02@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Tetratricopeptide repeats	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_11,TPR_16,TPR_2,Trans_reg_C
HKD1_k127_7301832_12	686340.Metal_0257	3.124e-67	232.0	COG0590@1|root,COG0590@2|Bacteria,1RE8P@1224|Proteobacteria,1S3V3@1236|Gammaproteobacteria,1XFFK@135618|Methylococcales	135618|Methylococcales	FJ	MafB19-like deaminase	-	-	3.5.4.1	ko:K01485	ko00240,ko00330,ko01100,map00240,map00330,map01100	-	R00974,R01411,R02922	RC00074,RC00514,RC00809	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD1_k127_7301832_1	234267.Acid_5940	8.046e-177	586.0	COG0515@1|root,COG0823@1|root,COG0515@2|Bacteria,COG0823@2|Bacteria,3Y2PK@57723|Acidobacteria	57723|Acidobacteria	KLTU	WD40 domain protein beta Propeller	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_7301832_24	1210884.HG799462_gene7923	7.465e-07	57.0	COG1595@1|root,COG1595@2|Bacteria,2IZ6J@203682|Planctomycetes	2|Bacteria	K	Sigma-70, region 4	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	PQQ_2,Sigma70_r2,Sigma70_r4_2,WD40
HKD1_k127_7301832_9	1379698.RBG1_1C00001G0608	2.476e-99	351.0	COG0515@1|root,COG5616@1|root,COG0515@2|Bacteria,COG5616@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K08282,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_16,TPR_2,TPR_8,TolB_N
HKD1_k127_7301832_17	234267.Acid_4775	1.256e-33	152.0	COG1361@1|root,COG1649@1|root,COG1361@2|Bacteria,COG1649@2|Bacteria	2|Bacteria	F	PFAM Uncharacterised BCR, COG1649	-	-	-	-	-	-	-	-	-	-	-	-	CHU_C,DUF11,Glyco_hydro_42M,PKD,SLH,WG_beta_rep
HKD1_k127_7301832_6	1123508.JH636453_gene5827	3.736e-120	432.0	COG4447@1|root,COG5276@1|root,COG4447@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_2,DUF1566,DUF4347,He_PIG
HKD1_k127_7301832_13	1267535.KB906767_gene4484	3.266e-56	203.0	293T3@1|root,2ZR8H@2|Bacteria	2|Bacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
HKD1_k127_7301832_8	948106.AWZT01000055_gene6058	8.127e-102	340.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2VJ2R@28216|Betaproteobacteria,1K3YI@119060|Burkholderiaceae	28216|Betaproteobacteria	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2
HKD1_k127_7301832_19	204669.Acid345_4011	1.732e-21	100.0	2ED19@1|root,336Y7@2|Bacteria,3Y95N@57723|Acidobacteria	57723|Acidobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7301832_3	1499967.BAYZ01000036_gene2415	3.96e-148	487.0	COG0557@1|root,COG0557@2|Bacteria,2NNV2@2323|unclassified Bacteria	2|Bacteria	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnb	-	3.1.13.1	ko:K01147,ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD1_k127_7301832_0	1047013.AQSP01000130_gene1861	3.291e-311	966.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,2NNS9@2323|unclassified Bacteria	2|Bacteria	EU	peptidase S9 prolyl oligopeptidase active site	yuxL	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PD40,Peptidase_S9
HKD1_k127_7304836_4	1205680.CAKO01000029_gene5258	5.04e-12	70.0	2EKP5@1|root,33ECX@2|Bacteria,1RD05@1224|Proteobacteria,2TZ3I@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD1_k127_7304836_1	204669.Acid345_0948	1.963e-166	537.0	COG0122@1|root,COG2169@1|root,COG0122@2|Bacteria,COG2169@2|Bacteria,3Y578@57723|Acidobacteria,2JKKV@204432|Acidobacteriia	204432|Acidobacteriia	K	AlkA N-terminal domain	-	-	3.2.2.21	ko:K13529	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,AlkA_N,HTH_18,HhH-GPD
HKD1_k127_7304836_0	234267.Acid_2820	1.48e-230	723.0	COG1501@1|root,COG1501@2|Bacteria,3Y35Y@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Glycoside hydrolase, clan GH-D	-	-	3.2.1.22	ko:K07407	ko00052,ko00561,ko00600,ko00603,map00052,map00561,map00600,map00603	-	R01101,R01103,R01104,R01194,R01329,R02926,R03634,R04019,R04470,R05549,R05961,R06091	RC00049,RC00059,RC00451	ko00000,ko00001,ko01000	-	-	-	Melibiase_2,Melibiase_2_C
HKD1_k127_7304836_2	880073.Calab_0031	1.318e-127	417.0	COG2017@1|root,COG2017@2|Bacteria,2NQA5@2323|unclassified Bacteria	2|Bacteria	G	Converts alpha-aldose to the beta-anomer	mro	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD1_k127_7304836_3	1396141.BATP01000061_gene4541	1.306e-51	191.0	28N64@1|root,2ZBFG@2|Bacteria,46Z9S@74201|Verrucomicrobia,2IWQS@203494|Verrucomicrobiae	2|Bacteria	S	Peptidase of plants and bacteria	-	-	-	-	-	-	-	-	-	-	-	-	BSP
HKD1_k127_7308195_16	234267.Acid_4169	1.479e-155	503.0	COG5000@1|root,COG5000@2|Bacteria,3Y2TD@57723|Acidobacteria	57723|Acidobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD1_k127_7308195_14	926566.Terro_2393	2.194e-163	526.0	COG2204@1|root,COG2204@2|Bacteria,3Y33M@57723|Acidobacteria,2JHW9@204432|Acidobacteriia	204432|Acidobacteriia	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_7308195_7	251221.35211765	2.425e-208	674.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_28	1267535.KB906767_gene4612	9.414e-19	90.0	COG0577@1|root,COG0577@2|Bacteria	1267535.KB906767_gene4612|-	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7308195_8	251221.35211765	2.802e-204	662.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_13	1183438.GKIL_4354	1.823e-181	599.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_2	204669.Acid345_4284	6.209e-245	781.0	COG0577@1|root,COG0577@2|Bacteria,3Y31H@57723|Acidobacteria,2JITF@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_17	234267.Acid_7944	5.805e-155	519.0	COG0577@1|root,COG0577@2|Bacteria,3Y3KJ@57723|Acidobacteria	234267.Acid_7944|-	V	FtsX-like permease family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7308195_3	204669.Acid345_0618	5.568e-223	717.0	COG0577@1|root,COG0577@2|Bacteria,3Y6E4@57723|Acidobacteria,2JM2S@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_0	1267533.KB906736_gene1071	3.609e-273	862.0	COG0577@1|root,COG0577@2|Bacteria,3Y6B8@57723|Acidobacteria,2JK7N@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_10	1267535.KB906767_gene2344	1.973e-190	625.0	COG0577@1|root,COG0577@2|Bacteria,3Y67P@57723|Acidobacteria,2JKNB@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_4	1183438.GKIL_4354	1.626e-217	704.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_9	251221.35211765	1.082e-199	649.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_1	1267533.KB906735_gene4874	1.607e-247	788.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_31	1267534.KB906756_gene628	4.741e-09	66.0	COG0577@1|root,COG0577@2|Bacteria,3Y3V2@57723|Acidobacteria,2JI74@204432|Acidobacteriia	204432|Acidobacteriia	V	MacB-like periplasmic core domain	-	-	-	-	-	-	-	-	-	-	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_5	251221.35211765	6.45e-216	696.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_6	251221.35211765	1.205e-215	695.0	COG0577@1|root,COG0577@2|Bacteria	2|Bacteria	V	efflux transmembrane transporter activity	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7308195_21	1267535.KB906767_gene630	2.11e-106	348.0	COG1136@1|root,COG1136@2|Bacteria,3Y2X0@57723|Acidobacteria,2JHYU@204432|Acidobacteriia	204432|Acidobacteriia	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_7308195_20	1267535.KB906767_gene632	2.121e-118	384.0	COG1136@1|root,COG1136@2|Bacteria,3Y2J0@57723|Acidobacteria,2JIKD@204432|Acidobacteriia	204432|Acidobacteriia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7308195_19	1183438.GKIL_2517	4.554e-132	434.0	COG0845@1|root,COG0845@2|Bacteria	2|Bacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_7308195_30	273121.WS0332	4.869e-12	70.0	COG0077@1|root,COG1605@1|root,COG0077@2|Bacteria,COG1605@2|Bacteria,1MU60@1224|Proteobacteria,42MGN@68525|delta/epsilon subdivisions,2YNAN@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	E	Chorismate mutase prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD1_k127_7308195_18	204669.Acid345_3110	2.337e-144	465.0	COG2876@1|root,COG2876@2|Bacteria,3Y64W@57723|Acidobacteria,2JMIX@204432|Acidobacteriia	204432|Acidobacteriia	E	NeuB family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_7308195_26	1173024.KI912148_gene4396	2.191e-53	201.0	COG2267@1|root,COG2267@2|Bacteria,1GQJU@1117|Cyanobacteria	1117|Cyanobacteria	I	Ndr family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_7308195_11	261292.Nit79A3_0166	8.588e-183	577.0	COG2876@1|root,COG2876@2|Bacteria,1QVAD@1224|Proteobacteria,2VZA1@28216|Betaproteobacteria,37241@32003|Nitrosomonadales	28216|Betaproteobacteria	H	DAHP synthetase I family	-	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	DAHP_synth_1
HKD1_k127_7308195_25	1408321.JNJD01000001_gene95	2.926e-64	236.0	COG0077@1|root,COG0077@2|Bacteria,1TPDN@1239|Firmicutes,248G7@186801|Clostridia,27IIG@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Prephenate dehydratase	pheA	-	4.2.1.51,5.4.99.5	ko:K04518,ko:K14170	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024,M00025	R00691,R01373,R01715	RC00360,RC03116	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,CM_2,PDT
HKD1_k127_7308195_12	215803.DB30_6944	2.211e-182	637.0	COG2373@1|root,COG2373@2|Bacteria,1MV7J@1224|Proteobacteria,42MJ8@68525|delta/epsilon subdivisions,2X2JP@28221|Deltaproteobacteria,2YY11@29|Myxococcales	28221|Deltaproteobacteria	S	A-macroglobulin complement component	-	-	-	-	-	-	-	-	-	-	-	-	A2M,A2M_N,A2M_N_2,A2M_comp,Thiol-ester_cl
HKD1_k127_7308195_27	1118235.CAJH01000018_gene1024	4.914e-48	179.0	COG0739@1|root,COG0739@2|Bacteria,1RK7E@1224|Proteobacteria,1RYS2@1236|Gammaproteobacteria,1X698@135614|Xanthomonadales	135614|Xanthomonadales	M	Peptidase family M23	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD1_k127_7308195_29	861299.J421_1420	4.928e-14	85.0	COG1376@1|root,COG1376@2|Bacteria	2|Bacteria	D	ErfK ybiS ycfS ynhG family protein	-	-	-	ko:K16291	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	SLH,YkuD
HKD1_k127_7308195_22	1499967.BAYZ01000038_gene2261	4.054e-102	337.0	COG0705@1|root,COG0705@2|Bacteria,2NPGI@2323|unclassified Bacteria	2|Bacteria	S	(Rhomboid) family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_7308195_23	1499967.BAYZ01000095_gene4087	4.042e-87	294.0	COG0388@1|root,COG0388@2|Bacteria	2|Bacteria	S	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD1_k127_7308195_15	886293.Sinac_3438	4.959e-159	525.0	COG4122@1|root,COG4122@2|Bacteria,2IXSM@203682|Planctomycetes	203682|Planctomycetes	S	O-methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7308195_24	1267533.KB906735_gene4675	1.4e-81	277.0	2D579@1|root,32TID@2|Bacteria,3Y88C@57723|Acidobacteria,2JNCR@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_731543_12	204669.Acid345_2506	1.42e-64	235.0	COG2304@1|root,COG2304@2|Bacteria,3Y2IE@57723|Acidobacteria,2JI1J@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_731543_16	477974.Daud_1154	6.723e-30	125.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1TQ33@1239|Firmicutes,249TZ@186801|Clostridia,26142@186807|Peptococcaceae	186801|Clostridia	L	DNA polymerase	polX	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD1_k127_731543_1	886293.Sinac_1501	1.412e-219	702.0	COG3591@1|root,COG3591@2|Bacteria,2IXPD@203682|Planctomycetes	203682|Planctomycetes	E	Peptidase S46	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S46
HKD1_k127_731543_20	1340493.JNIF01000004_gene952	2.873e-05	56.0	COG0671@1|root,COG1075@1|root,COG0671@2|Bacteria,COG1075@2|Bacteria,3Y7BS@57723|Acidobacteria	57723|Acidobacteria	I	LssY C-terminus	-	-	-	-	-	-	-	-	-	-	-	-	LssY_C
HKD1_k127_731543_3	927677.ALVU02000001_gene2236	6.812e-194	618.0	COG0477@1|root,COG0477@2|Bacteria,1G155@1117|Cyanobacteria	1117|Cyanobacteria	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_731543_17	589865.DaAHT2_0734	1.996e-23	106.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,43BPD@68525|delta/epsilon subdivisions,2X70Q@28221|Deltaproteobacteria,2MNXU@213118|Desulfobacterales	28221|Deltaproteobacteria	T	PFAM response regulator receiver	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD1_k127_731543_6	204669.Acid345_2300	1.351e-112	394.0	COG5316@1|root,COG5316@2|Bacteria,3Y46P@57723|Acidobacteria,2JMJ4@204432|Acidobacteriia	204432|Acidobacteriia	S	Domain of unknown function (DUF4139)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4139
HKD1_k127_731543_14	177437.HRM2_33460	1.385e-36	152.0	COG0589@1|root,COG0589@2|Bacteria,1MVZS@1224|Proteobacteria,42QGY@68525|delta/epsilon subdivisions,2WKHR@28221|Deltaproteobacteria,2MJDT@213118|Desulfobacterales	28221|Deltaproteobacteria	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_731543_0	765420.OSCT_1210	8.867e-221	697.0	COG0281@1|root,COG0281@2|Bacteria,2G65R@200795|Chloroflexi,376YS@32061|Chloroflexia	32061|Chloroflexia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_731543_2	469383.Cwoe_1088	4.799e-204	642.0	COG0372@1|root,COG0372@2|Bacteria,2GJ7E@201174|Actinobacteria,4CPID@84995|Rubrobacteria	84995|Rubrobacteria	C	Belongs to the citrate synthase family	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_731543_19	1122182.KB903833_gene5220	8.607e-09	63.0	COG1734@1|root,COG1734@2|Bacteria,2GJBE@201174|Actinobacteria,4DDBG@85008|Micromonosporales	201174|Actinobacteria	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD1_k127_731543_5	350688.Clos_0825	1.252e-138	449.0	COG0031@1|root,COG0031@2|Bacteria,1UZEQ@1239|Firmicutes,24BCR@186801|Clostridia,36G6F@31979|Clostridiaceae	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_731543_4	391625.PPSIR1_32884	2.925e-169	553.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,42MCY@68525|delta/epsilon subdivisions,2WIWJ@28221|Deltaproteobacteria,2YYYV@29|Myxococcales	28221|Deltaproteobacteria	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD1_k127_731543_18	391625.PPSIR1_32879	7.308e-12	68.0	COG1918@1|root,COG1918@2|Bacteria,1Q29B@1224|Proteobacteria,42VSV@68525|delta/epsilon subdivisions,2WS7A@28221|Deltaproteobacteria,2Z28N@29|Myxococcales	28221|Deltaproteobacteria	P	FeoA	-	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD1_k127_731543_15	324602.Caur_0645	2.447e-33	144.0	COG1232@1|root,COG1232@2|Bacteria,2G687@200795|Chloroflexi,375MK@32061|Chloroflexia	32061|Chloroflexia	H	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	-	-	1.3.3.15,1.3.3.4	ko:K00231	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03222,R04178	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD1_k127_731543_10	1244869.H261_10452	1.124e-66	239.0	COG2159@1|root,COG2159@2|Bacteria,1MUUR@1224|Proteobacteria,2TSQB@28211|Alphaproteobacteria,2JU12@204441|Rhodospirillales	204441|Rhodospirillales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD1_k127_731543_11	562970.Btus_1277	2.165e-65	231.0	COG1028@1|root,COG1028@2|Bacteria,1TR8Y@1239|Firmicutes,4HFAC@91061|Bacilli,279AR@186823|Alicyclobacillaceae	91061|Bacilli	IQ	NAD dependent epimerase/dehydratase family	-	-	-	ko:K07535	ko00362,ko01120,ko01220,map00362,map01120,map01220	M00540	R05582	RC00154	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HKD1_k127_731543_7	1232410.KI421421_gene3270	2.604e-89	307.0	COG1775@1|root,COG1775@2|Bacteria,1NNW9@1224|Proteobacteria,42RTN@68525|delta/epsilon subdivisions,2WNYI@28221|Deltaproteobacteria,43V0Q@69541|Desulfuromonadales	28221|Deltaproteobacteria	E	2-hydroxyglutaryl-CoA dehydratase, D-component	-	-	1.3.7.8	ko:K04112	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD1_k127_731543_8	316057.RPD_1537	1.729e-88	306.0	COG1775@1|root,COG1775@2|Bacteria,1NKED@1224|Proteobacteria,2U31W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	benzoyl-CoA reductase	-	-	1.3.7.8	ko:K04113	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00541	R02451	RC00002,RC01839	ko00000,ko00001,ko00002,ko01000	-	-	-	HGD-D
HKD1_k127_731543_9	398767.Glov_2399	4.001e-80	275.0	COG1924@1|root,COG1924@2|Bacteria,1R6HU@1224|Proteobacteria,42RWX@68525|delta/epsilon subdivisions,2WNC9@28221|Deltaproteobacteria,43V8M@69541|Desulfuromonadales	28221|Deltaproteobacteria	I	BadF/BadG/BcrA/BcrD ATPase family	yjiL	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD1_k127_731543_13	641107.CDLVIII_3500	1.808e-50	190.0	COG1775@1|root,COG1924@1|root,COG1775@2|Bacteria,COG1924@2|Bacteria,1TQSD@1239|Firmicutes,2481W@186801|Clostridia,36F30@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	hgdC_1	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,HGD-D
HKD1_k127_734871_5	997346.HMPREF9374_1651	5.007e-115	415.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,4HA64@91061|Bacilli,27CSD@186824|Thermoactinomycetaceae	91061|Bacilli	L	PD-(D/E)XK nuclease superfamily	-	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_734871_2	1157708.KB907458_gene1736	2.618e-143	466.0	COG0412@1|root,COG0412@2|Bacteria,1MW88@1224|Proteobacteria,2VMBW@28216|Betaproteobacteria,4AE3K@80864|Comamonadaceae	28216|Betaproteobacteria	Q	Dienelactone hydrolase family	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH,SnoaL_2
HKD1_k127_734871_9	264732.Moth_0156	4.388e-91	318.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,25E7A@186801|Clostridia	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2,Usp
HKD1_k127_734871_16	113395.AXAI01000032_gene685	1.817e-40	159.0	COG0300@1|root,COG0300@2|Bacteria,1R3VU@1224|Proteobacteria,2TWRJ@28211|Alphaproteobacteria,3K6MX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	-	-	-	-	-	-	-	-	-	DUF35_N,OB_aCoA_assoc,adh_short,adh_short_C2
HKD1_k127_734871_7	234267.Acid_2875	2.313e-105	356.0	COG3844@1|root,COG3844@2|Bacteria,3Y984@57723|Acidobacteria	57723|Acidobacteria	F	Aminotransferase class-V	-	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD1_k127_734871_18	1121374.KB891589_gene48	1.071e-30	136.0	COG0662@1|root,COG0662@2|Bacteria,1QZVZ@1224|Proteobacteria,1T4RF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_734871_20	861299.J421_0665	1.31e-12	71.0	COG1977@1|root,COG1977@2|Bacteria	2|Bacteria	H	Mo-molybdopterin cofactor metabolic process	cysO	GO:0000096,GO:0000097,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006520,GO:0006534,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009069,GO:0009070,GO:0009987,GO:0016053,GO:0019344,GO:0019752,GO:0032991,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.7.7.80,2.8.1.11	ko:K03636,ko:K21147	ko04122,map04122	-	R07459,R07461	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiS
HKD1_k127_734871_13	517418.Ctha_2714	1.102e-58	214.0	COG0500@1|root,COG2226@2|Bacteria,1FFN6@1090|Chlorobi	1090|Chlorobi	Q	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_734871_4	63577.G9NQK4	1.694e-131	428.0	COG1087@1|root,KOG1371@2759|Eukaryota,39KCQ@33154|Opisthokonta,3PBHS@4751|Fungi,3RN10@4890|Ascomycota	4751|Fungi	M	RmlD substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GDP_Man_Dehyd
HKD1_k127_734871_11	204669.Acid345_3127	8.513e-63	225.0	COG0500@1|root,COG2226@2|Bacteria,3Y8WR@57723|Acidobacteria	57723|Acidobacteria	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_734871_6	1304872.JAGC01000003_gene3579	8.522e-112	370.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,42MCE@68525|delta/epsilon subdivisions,2WIYP@28221|Deltaproteobacteria,2MGAZ@213115|Desulfovibrionales	28221|Deltaproteobacteria	M	PFAM Glycosyl transferase family 2	-	-	2.4.2.53	ko:K10012	ko00520,ko01503,map00520,map01503	M00721,M00761	R07661	RC00005,RC02954	ko00000,ko00001,ko00002,ko01000,ko01005,ko02000	4.D.2.1.8	GT2	-	Glycos_transf_2
HKD1_k127_734871_0	1128427.KB904821_gene205	3.772e-184	596.0	COG0367@1|root,COG0367@2|Bacteria,1G1WZ@1117|Cyanobacteria,1H9W9@1150|Oscillatoriales	1117|Cyanobacteria	E	Asparagine synthase	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_734871_8	468059.AUHA01000002_gene1160	8.557e-93	317.0	COG1331@1|root,COG1331@2|Bacteria,4NIPN@976|Bacteroidetes	976|Bacteroidetes	O	Highly conserved protein containing a thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_88
HKD1_k127_734871_14	1267535.KB906767_gene4795	2.547e-54	198.0	COG2080@1|root,COG2080@2|Bacteria,3Y4DP@57723|Acidobacteria,2JJ2F@204432|Acidobacteriia	204432|Acidobacteriia	C	2Fe-2S -binding	-	-	-	ko:K13483	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002	-	-	-	Fer2,Fer2_2,TAT_signal
HKD1_k127_734871_3	886293.Sinac_6836	5.88e-143	481.0	COG1529@1|root,COG1529@2|Bacteria,2IYIN@203682|Planctomycetes	203682|Planctomycetes	C	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.17.1.4	ko:K11177	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_734871_10	880073.Calab_1108	2.459e-83	288.0	COG1319@1|root,COG1319@2|Bacteria,2NQUQ@2323|unclassified Bacteria	2|Bacteria	C	CO dehydrogenase flavoprotein C-terminal domain	-	-	1.17.1.4	ko:K11178	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_734871_19	234267.Acid_2426	4.119e-21	104.0	COG5588@1|root,COG5588@2|Bacteria,3Y7RN@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1326)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1326
HKD1_k127_734871_17	1454007.JAUG01000089_gene718	5.935e-37	145.0	COG0662@1|root,COG0662@2|Bacteria,4P4J0@976|Bacteroidetes,1IY82@117747|Sphingobacteriia	976|Bacteroidetes	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_734871_15	518766.Rmar_1541	6.025e-53	194.0	COG0663@1|root,COG0663@2|Bacteria,4NG6R@976|Bacteroidetes,1FJB4@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	S	Bacterial transferase hexapeptide (six repeats)	dapH	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_734871_12	1128421.JAGA01000002_gene1985	1.169e-62	243.0	COG0823@1|root,COG4995@1|root,COG0823@2|Bacteria,COG4995@2|Bacteria	2|Bacteria	S	CHAT domain	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	CHAT,PD40,WD40
HKD1_k127_734871_21	1961.JOAK01000025_gene3553	1.273e-06	60.0	2ECD7@1|root,336BF@2|Bacteria,2IH9P@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_734871_1	420324.KI912007_gene8917	2.446e-169	542.0	COG0654@1|root,COG0654@2|Bacteria,1P1NX@1224|Proteobacteria,2TRZX@28211|Alphaproteobacteria,1JTU0@119045|Methylobacteriaceae	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD1_k127_7506514_2	997346.HMPREF9374_2714	1.114e-61	217.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,4HFZ2@91061|Bacilli,27BRG@186824|Thermoactinomycetaceae	91061|Bacilli	F	Phosphoribosyl transferase domain	hpt	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.4.2.8,6.3.4.19	ko:K00760,ko:K15780	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000,ko03016	-	-	-	Pribosyltran
HKD1_k127_7506514_1	1267534.KB906754_gene3465	1.951e-103	345.0	COG0491@1|root,COG0491@2|Bacteria,3Y54H@57723|Acidobacteria,2JM9F@204432|Acidobacteriia	204432|Acidobacteriia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_7506514_3	37727.XP_002153739.1	2.709e-56	221.0	KOG0266@1|root,KOG0271@1|root,KOG0266@2759|Eukaryota,KOG0271@2759|Eukaryota,38B6D@33154|Opisthokonta,3NZ4C@4751|Fungi,3QPCR@4890|Ascomycota,20AVS@147545|Eurotiomycetes,3S3IJ@5042|Eurotiales	4751|Fungi	S	Encoded by	-	-	-	-	-	-	-	-	-	-	-	-	NACHT,PNP_UDP_1,WD40
HKD1_k127_7506514_0	868595.Desca_2070	6.379e-145	469.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,260HR@186807|Peptococcaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HKD1_k127_7548859_26	1267533.KB906738_gene2436	1.491e-18	88.0	COG1629@1|root,COG4771@2|Bacteria,3Y7F9@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_7548859_19	1192034.CAP_5172	5.952e-100	341.0	COG2114@1|root,COG2114@2|Bacteria,1MY09@1224|Proteobacteria	1224|Proteobacteria	T	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	CHASE3,Guanylate_cyc
HKD1_k127_7548859_0	204669.Acid345_3246	0.0	1355.0	COG1472@1|root,COG1472@2|Bacteria,3Y3H7@57723|Acidobacteria,2JKHJ@204432|Acidobacteriia	204432|Acidobacteriia	G	PA14 domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C,PA14
HKD1_k127_7548859_23	234267.Acid_3128	1.929e-66	245.0	COG3942@1|root,COG3942@2|Bacteria	2|Bacteria	S	pathogenesis	gsp	-	3.5.1.78,6.3.1.8	ko:K01460	ko00480,ko01100,map00480,map01100	-	R01917,R01918	RC00090,RC00096	ko00000,ko00001,ko01000	-	-	-	Big_2,CHAP,GBS_Bsp-like,GSP_synth
HKD1_k127_7548859_1	234267.Acid_2987	0.0	1303.0	COG3485@1|root,COG3485@2|Bacteria,3Y3FU@57723|Acidobacteria	57723|Acidobacteria	Q	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_7548859_8	234267.Acid_5646	6.808e-212	664.0	COG2271@1|root,COG2271@2|Bacteria,3Y2VG@57723|Acidobacteria	57723|Acidobacteria	G	PFAM Major Facilitator Superfamily	-	-	-	ko:K08191	-	-	-	-	ko00000,ko02000	2.A.1.14.2	-	-	MFS_1
HKD1_k127_7548859_3	234267.Acid_5647	3.344e-293	907.0	COG3507@1|root,COG3507@2|Bacteria,3Y89B@57723|Acidobacteria	57723|Acidobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.37	ko:K01198	ko00520,ko01100,map00520,map01100	-	R01433	RC00467	ko00000,ko00001,ko01000	-	GH43	-	Glyco_hydro_43
HKD1_k127_7548859_6	234267.Acid_2989	1.372e-243	760.0	COG3507@1|root,COG3507@2|Bacteria	2|Bacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43,RicinB_lectin_2
HKD1_k127_7548859_20	234267.Acid_2990	1.554e-97	337.0	COG3458@1|root,COG3458@2|Bacteria,3Y7GC@57723|Acidobacteria	57723|Acidobacteria	Q	cephalosporin-C deacetylase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7548859_14	234267.Acid_6874	2.314e-113	383.0	COG0491@1|root,COG0491@2|Bacteria,3Y44S@57723|Acidobacteria	57723|Acidobacteria	S	Metallo-beta-lactamase superfamily	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD1_k127_7548859_4	1382304.JNIL01000001_gene1413	8.375e-273	854.0	COG0129@1|root,COG0129@2|Bacteria,1U56J@1239|Firmicutes,4HD31@91061|Bacilli	91061|Bacilli	EG	Belongs to the IlvD Edd family	-	-	4.2.1.82	ko:K22396	ko00040,map00040	-	R02429	RC00543	ko00000,ko00001,ko01000	-	-	-	ILVD_EDD
HKD1_k127_7548859_17	278963.ATWD01000001_gene2789	1.173e-100	335.0	COG3970@1|root,COG3970@2|Bacteria,3Y6J7@57723|Acidobacteria,2JKPG@204432|Acidobacteriia	204432|Acidobacteriia	S	Fumarylacetoacetate (FAA) hydrolase family	-	-	4.2.1.141	ko:K14259	ko00040,map00040	-	R09186	RC00429	ko00000,ko00001,ko01000	-	-	-	FAA_hydrolase
HKD1_k127_7548859_12	497964.CfE428DRAFT_0590	7.231e-184	589.0	COG1012@1|root,COG1012@2|Bacteria,46SIA@74201|Verrucomicrobia	74201|Verrucomicrobia	C	Aldehyde dehydrogenase family	-	-	1.2.1.26	ko:K13877	ko00040,ko00053,map00040,map00053	-	R00264	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD1_k127_7548859_10	204669.Acid345_3245	7.779e-202	634.0	COG0296@1|root,COG2382@1|root,COG0296@2|Bacteria,COG2382@2|Bacteria,3Y2ZN@57723|Acidobacteria,2JP2N@204432|Acidobacteriia	204432|Acidobacteriia	GP	Putative esterase	-	-	-	ko:K07214	-	-	-	-	ko00000	-	-	-	Esterase
HKD1_k127_7548859_7	694427.Palpr_1623	2.018e-242	775.0	COG1501@1|root,COG1501@2|Bacteria,4NE1H@976|Bacteroidetes,2FM4Z@200643|Bacteroidia,22W3H@171551|Porphyromonadaceae	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 31 family	-	-	3.2.1.177	ko:K01811	-	-	-	-	ko00000,ko01000	-	GH31	-	DUF4968,DUF5110,Gal_mutarotas_2,Glyco_hydro_31
HKD1_k127_7548859_32	1270196.JCKI01000002_gene255	0.0001525	47.0	COG1472@1|root,COG1472@2|Bacteria,4NE90@976|Bacteroidetes,1IR7S@117747|Sphingobacteriia	976|Bacteroidetes	G	Fibronectin type III-like domain	-	-	3.2.1.21	ko:K05349	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	GH3	-	Fn3-like,Glyco_hydro_3,Glyco_hydro_3_C
HKD1_k127_7548859_5	234267.Acid_6747	1.003e-267	832.0	COG0459@1|root,COG0459@2|Bacteria,3Y37I@57723|Acidobacteria	57723|Acidobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_7548859_25	1382359.JIAL01000001_gene1679	2.932e-39	148.0	COG0234@1|root,COG0234@2|Bacteria,3Y4VQ@57723|Acidobacteria,2JJEF@204432|Acidobacteriia	204432|Acidobacteriia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_7548859_21	1174528.JH992898_gene1315	7.092e-95	321.0	COG2367@1|root,COG2367@2|Bacteria,1G1KE@1117|Cyanobacteria,1JIXY@1189|Stigonemataceae	1117|Cyanobacteria	V	Beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2
HKD1_k127_7548859_30	234267.Acid_5252	7.865e-05	48.0	COG3829@1|root,COG3829@2|Bacteria,3Y5ZF@57723|Acidobacteria	57723|Acidobacteria	KT	PFAM helix-turn-helix, Fis-type	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8
HKD1_k127_7548859_15	1121459.AQXE01000001_gene2630	2.757e-109	363.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,42M8A@68525|delta/epsilon subdivisions,2WJY0@28221|Deltaproteobacteria,2M95X@213115|Desulfovibrionales	28221|Deltaproteobacteria	F	PFAM SAICAR synthetase	purC	GO:0003674,GO:0003824,GO:0004639,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006188,GO:0006189,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009117,GO:0009123,GO:0009124,GO:0009126,GO:0009127,GO:0009150,GO:0009152,GO:0009156,GO:0009161,GO:0009165,GO:0009167,GO:0009168,GO:0009259,GO:0009260,GO:0009987,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046040,GO:0046390,GO:0046483,GO:0055086,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD1_k127_7548859_27	204669.Acid345_2164	1.078e-17	89.0	COG2318@1|root,COG2318@2|Bacteria,3Y501@57723|Acidobacteria,2JJGU@204432|Acidobacteriia	204432|Acidobacteriia	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2
HKD1_k127_7548859_29	1269813.ATUL01000002_gene940	9.836e-06	55.0	COG2823@1|root,COG2823@2|Bacteria,1MY8V@1224|Proteobacteria,1S2D4@1236|Gammaproteobacteria,1X04P@135613|Chromatiales	135613|Chromatiales	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_7548859_22	1174528.JH992898_gene2447	1.761e-86	291.0	COG3467@1|root,COG3467@2|Bacteria,1G4RC@1117|Cyanobacteria,1JJWX@1189|Stigonemataceae	1117|Cyanobacteria	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07005	-	-	-	-	ko00000	-	-	-	Pyridox_ox_2
HKD1_k127_7548859_33	551789.ATVJ01000001_gene1257	0.000182	49.0	COG2204@1|root,COG2204@2|Bacteria,1MWW5@1224|Proteobacteria,2TXAZ@28211|Alphaproteobacteria,43X5S@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	COG1221 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
HKD1_k127_7548859_13	1121920.AUAU01000012_gene2631	2.581e-114	407.0	COG1629@1|root,COG4771@2|Bacteria,3Y3ZU@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_7548859_18	1122604.JONR01000025_gene4602	3.75e-100	350.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1SHX7@1236|Gammaproteobacteria,1X4MN@135614|Xanthomonadales	135614|Xanthomonadales	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Trans_reg_C
HKD1_k127_7548859_9	1340493.JNIF01000003_gene3613	5.112e-202	675.0	COG1470@1|root,COG1470@2|Bacteria	2|Bacteria	S	cell adhesion involved in biofilm formation	-	-	-	ko:K02014,ko:K11031	ko02024,map02024	-	-	-	ko00000,ko00001,ko02000,ko02042	1.B.14	-	-	Alginate_lyase2,CBM_6,CarbopepD_reg_2,F5_F8_type_C,Plug,Thiol_cytolys_C,Thiol_cytolysin,TonB_dep_Rec
HKD1_k127_7548859_11	1123242.JH636434_gene4898	1.089e-190	625.0	COG0642@1|root,COG0784@1|root,COG5002@1|root,COG0784@2|Bacteria,COG2205@2|Bacteria,COG5002@2|Bacteria,2IX8Z@203682|Planctomycetes	203682|Planctomycetes	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD1_k127_7548859_16	945713.IALB_2163	2.715e-106	360.0	COG4409@1|root,COG4409@2|Bacteria	2|Bacteria	G	exo-alpha-(2->6)-sialidase activity	-	-	-	-	-	-	-	-	-	-	-	-	BNR_2
HKD1_k127_7548859_2	1419583.V466_02355	5.004e-298	923.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,1SYC8@1236|Gammaproteobacteria,1YS5T@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_7548859_24	395961.Cyan7425_4762	1.406e-61	218.0	2DC9X@1|root,2ZDDA@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7548859_28	240016.ABIZ01000001_gene988	8.619e-08	54.0	COG1943@1|root,COG1943@2|Bacteria,46VP6@74201|Verrucomicrobia,2IVSQ@203494|Verrucomicrobiae	203494|Verrucomicrobiae	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_7620391_8	234267.Acid_5120	1.202e-18	85.0	COG0050@1|root,COG0050@2|Bacteria,3Y2JG@57723|Acidobacteria	57723|Acidobacteria	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_7620391_0	161156.JQKW01000004_gene1674	2.132e-282	883.0	COG0480@1|root,COG0480@2|Bacteria,2GH6R@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_7620391_4	1232410.KI421428_gene1226	1.296e-63	221.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,42QR7@68525|delta/epsilon subdivisions,2WNFM@28221|Deltaproteobacteria,43U5Z@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	GO:0000028,GO:0003674,GO:0003676,GO:0003723,GO:0003729,GO:0003735,GO:0005198,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0019843,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD1_k127_7620391_3	204669.Acid345_1221	2.748e-65	225.0	COG0048@1|root,COG0048@2|Bacteria,3Y4JQ@57723|Acidobacteria,2JJ7D@204432|Acidobacteriia	204432|Acidobacteriia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD1_k127_7620391_9	247490.KSU1_D0433	5.229e-10	69.0	COG0457@1|root,COG0457@2|Bacteria	247490.KSU1_D0433|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7620391_1	926566.Terro_0250	7.461e-122	407.0	COG1109@1|root,COG1109@2|Bacteria,3Y36F@57723|Acidobacteria,2JHU9@204432|Acidobacteriia	204432|Acidobacteriia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_7620391_10	589865.DaAHT2_0444	4.984e-05	51.0	COG4856@1|root,COG4856@2|Bacteria,1REEU@1224|Proteobacteria,42RY2@68525|delta/epsilon subdivisions,2WNZH@28221|Deltaproteobacteria,2MIQJ@213118|Desulfobacterales	28221|Deltaproteobacteria	S	YbbR-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD1_k127_7620391_5	204669.Acid345_0278	2.464e-57	210.0	COG1624@1|root,COG1624@2|Bacteria,3Y7NU@57723|Acidobacteria	57723|Acidobacteria	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	-	-	-	-	-	-	-	-	-	-	DisA_N
HKD1_k127_7620391_6	1382356.JQMP01000004_gene611	1.679e-53	203.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,2G5WG@200795|Chloroflexi,27XRJ@189775|Thermomicrobia	189775|Thermomicrobia	S	Belongs to the peptidase M50B family	-	-	-	-	-	-	-	-	-	-	-	-	CBS,Peptidase_M50
HKD1_k127_7620391_2	391625.PPSIR1_34013	8.202e-82	293.0	COG1716@1|root,COG2114@1|root,COG2203@1|root,COG1716@2|Bacteria,COG2114@2|Bacteria,COG2203@2|Bacteria,1R45Z@1224|Proteobacteria,43AMH@68525|delta/epsilon subdivisions,2X61H@28221|Deltaproteobacteria,2Z38T@29|Myxococcales	28221|Deltaproteobacteria	T	Adenylyl- / guanylyl cyclase, catalytic domain	-	-	4.6.1.1	ko:K01768	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000	-	-	-	FHA,GAF,Guanylate_cyc
HKD1_k127_7620391_7	204669.Acid345_2892	5.659e-25	121.0	COG4932@1|root,COG4932@2|Bacteria,3Y5W1@57723|Acidobacteria,2JNVI@204432|Acidobacteriia	204432|Acidobacteriia	M	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD1_k127_7620391_11	1331060.RLDS_17745	5.674e-05	51.0	COG1629@1|root,COG4771@2|Bacteria,1PSM0@1224|Proteobacteria,2U3MX@28211|Alphaproteobacteria,2K0HM@204457|Sphingomonadales	204457|Sphingomonadales	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,Plug,TonB_dep_Rec
HKD1_k127_7722206_10	1122604.JONR01000032_gene93	1.372e-25	110.0	COG0657@1|root,COG0657@2|Bacteria,1N5QB@1224|Proteobacteria,1SZEF@1236|Gammaproteobacteria	1236|Gammaproteobacteria	I	esterase lipase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7722206_6	1449049.JONW01000005_gene1358	3.847e-42	160.0	29DWE@1|root,300UA@2|Bacteria,1RDK5@1224|Proteobacteria,2TY0U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Cytochrome P460	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_P460
HKD1_k127_7722206_5	1202532.FF52_03025	8.941e-47	175.0	29PQU@1|root,30AP1@2|Bacteria,4NP4D@976|Bacteroidetes,1I8TD@117743|Flavobacteriia,2NW31@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HKD1_k127_7722206_0	595494.Tola_1286	3.298e-200	644.0	COG0469@1|root,COG0469@2|Bacteria,1NNNX@1224|Proteobacteria,1RYF5@1236|Gammaproteobacteria	1236|Gammaproteobacteria	G	Pyruvate kinase	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK
HKD1_k127_7722206_11	1479237.JMLY01000001_gene2639	5.266e-19	93.0	COG0517@1|root,COG0517@2|Bacteria,1QTVM@1224|Proteobacteria,1SFWU@1236|Gammaproteobacteria,46BCN@72275|Alteromonadaceae	1236|Gammaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_7722206_3	240292.Ava_C0139	3.66e-51	191.0	COG2823@1|root,COG2823@2|Bacteria,1GBV7@1117|Cyanobacteria,1HPUI@1161|Nostocales	1117|Cyanobacteria	S	bacterial OsmY and nodulation domain	-	-	-	-	-	-	-	-	-	-	-	-	BON
HKD1_k127_7722206_7	886293.Sinac_4160	3.575e-33	135.0	COG0071@1|root,COG0071@2|Bacteria,2J11X@203682|Planctomycetes	203682|Planctomycetes	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_7722206_9	351160.RCIX772	1.938e-29	123.0	arCOG10439@1|root,arCOG10439@2157|Archaea,2Y63F@28890|Euryarchaeota	28890|Euryarchaeota	S	Protein of unknown function (DUF3788)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3788
HKD1_k127_7722206_2	595460.RRSWK_00985	1.308e-77	269.0	COG1796@1|root,COG1796@2|Bacteria	2|Bacteria	L	DNA-directed DNA polymerase activity	dpbF	-	3.1.11.5	ko:K02347,ko:K03581,ko:K04477	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,HHH_8
HKD1_k127_7722206_8	631362.Thi970DRAFT_03437	5.929e-33	133.0	2CD2C@1|root,32W1R@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7722206_4	767817.Desgi_4194	6.06e-50	192.0	COG2843@1|root,COG2843@2|Bacteria,1UCFI@1239|Firmicutes,25CHR@186801|Clostridia,2676Q@186807|Peptococcaceae	186801|Clostridia	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap,Peptidase_M15
HKD1_k127_7722206_1	395494.Galf_2867	1.103e-180	574.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2VGZV@28216|Betaproteobacteria,44VMC@713636|Nitrosomonadales	28216|Betaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	pap	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD1_k127_774313_23	1121373.KB903640_gene3730	1.949e-73	262.0	COG2911@1|root,COG3291@1|root,COG4733@1|root,COG2911@2|Bacteria,COG3291@2|Bacteria,COG4733@2|Bacteria,4NHHA@976|Bacteroidetes,47XBX@768503|Cytophagia	976|Bacteroidetes	G	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	Big_4,CHU_C,Calx-beta,He_PIG,NHL,TIG,fn3
HKD1_k127_774313_46	1047013.AQSP01000137_gene547	4.594e-27	125.0	COG0582@1|root,COG0582@2|Bacteria,2NRA8@2323|unclassified Bacteria	2|Bacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	ko:K14059	-	-	-	-	ko00000	-	-	-	Phage_int_SAM_3,Phage_integrase
HKD1_k127_774313_35	118166.JH976538_gene5065	2.231e-45	178.0	COG2202@1|root,COG2203@1|root,COG4585@1|root,COG2202@2|Bacteria,COG2203@2|Bacteria,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	2.7.13.3	ko:K07683	ko02020,map02020	M00483	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	GAF_2,HATPase_c,HisKA_3,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_774313_49	671143.DAMO_1779	1.568e-23	113.0	COG0784@1|root,COG2199@1|root,COG2204@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2204@2|Bacteria,COG3706@2|Bacteria,COG4191@2|Bacteria,2NP93@2323|unclassified Bacteria	2|Bacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	ko:K21025	ko02025,map02025	-	-	-	ko00000,ko00001	-	-	-	HATPase_c,HisKA,Hpt,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_774313_61	290315.Clim_0050	2.483e-12	76.0	2EDTP@1|root,337NZ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_67	1249627.D779_3143	7.715e-06	59.0	COG3291@1|root,COG3291@2|Bacteria,1R5MU@1224|Proteobacteria,1RZ6G@1236|Gammaproteobacteria,1X1H2@135613|Chromatiales	135613|Chromatiales	S	Repeats in polycystic kidney disease 1 (PKD1) and other proteins	-	-	-	-	-	-	-	-	-	-	-	-	PKD
HKD1_k127_774313_29	234267.Acid_2646	5.909e-56	205.0	COG2834@1|root,COG2834@2|Bacteria,3Y7NW@57723|Acidobacteria	57723|Acidobacteria	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_0	234267.Acid_2647	0.0	1386.0	COG4409@1|root,COG4447@1|root,COG4409@2|Bacteria,COG4447@2|Bacteria,3Y6ZR@57723|Acidobacteria	57723|Acidobacteria	M	Sortilin, neurotensin receptor 3,	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_774313_39	1185876.BN8_02959	1.006e-38	156.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,DUF4440,SnoaL_2,SnoaL_3,YkuD
HKD1_k127_774313_21	330214.NIDE0778	1.285e-78	285.0	COG5000@1|root,COG5000@2|Bacteria	2|Bacteria	T	phosphorelay sensor kinase activity	pilS	-	2.7.13.3	ko:K02668	ko02020,map02020	M00501	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	HATPase_c,HisKA,PAS,PAS_4,PAS_9
HKD1_k127_774313_10	1047013.AQSP01000115_gene361	1.914e-124	415.0	COG2204@1|root,COG2204@2|Bacteria,2NNWS@2323|unclassified Bacteria	2|Bacteria	T	Two component, sigma54 specific, transcriptional regulator, Fis family	nla19	-	-	ko:K07713,ko:K07714,ko:K19641	ko02020,map02020	M00499,M00500,M00772	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_774313_52	204669.Acid345_1569	2.729e-19	95.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD1_k127_774313_53	204669.Acid345_1569	6.679e-18	89.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD1_k127_774313_60	204669.Acid345_1569	7.2e-14	78.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD1_k127_774313_51	204669.Acid345_2988	1.93e-19	94.0	COG4968@1|root,COG4968@2|Bacteria,3Y98E@57723|Acidobacteria,2JP4Y@204432|Acidobacteriia	57723|Acidobacteria	NU	Pfam:N_methyl_2	-	-	-	-	-	-	-	-	-	-	-	-	N_methyl
HKD1_k127_774313_42	204669.Acid345_2733	1.305e-32	145.0	COG5617@1|root,COG5617@2|Bacteria,3Y46S@57723|Acidobacteria,2JHJW@204432|Acidobacteriia	204432|Acidobacteriia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
HKD1_k127_774313_56	118173.KB235914_gene993	3.683e-15	89.0	COG5617@1|root,COG5617@2|Bacteria,1G6H7@1117|Cyanobacteria,1HGEF@1150|Oscillatoriales	1117|Cyanobacteria	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
HKD1_k127_774313_30	330214.NIDE3434	2.067e-51	193.0	COG1277@1|root,COG1277@2|Bacteria	2|Bacteria	-	-	pilI	-	-	-	-	-	-	-	-	-	-	-	ABC2_membrane_2
HKD1_k127_774313_40	204669.Acid345_1573	1.245e-35	151.0	COG0457@1|root,COG0457@2|Bacteria	204669.Acid345_1573|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_20	330214.NIDE3435	1.183e-82	286.0	COG1131@1|root,COG1131@2|Bacteria,3J122@40117|Nitrospirae	40117|Nitrospirae	V	AAA domain, putative AbiEii toxin, Type IV TA system	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_774313_62	1121920.AUAU01000039_gene1426	5.218e-11	78.0	COG2133@1|root,COG2335@1|root,COG2133@2|Bacteria,COG2335@2|Bacteria,3Y5VT@57723|Acidobacteria	57723|Acidobacteria	M	A domain in the BMP inhibitor chordin and in microbial proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CHRD
HKD1_k127_774313_8	1122138.AQUZ01000019_gene8188	1.955e-145	519.0	COG2133@1|root,COG2133@2|Bacteria	2|Bacteria	G	pyrroloquinoline quinone binding	sndH	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_774313_55	335543.Sfum_0807	2.246e-16	96.0	COG3291@1|root,COG3291@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	3.4.24.3	ko:K01387	-	-	-	-	ko00000,ko01000,ko01002,ko02042	-	-	-	PKD,PPC,Peptidase_M9,Peptidase_M9_N
HKD1_k127_774313_9	247490.KSU1_C0714	2.602e-145	518.0	COG1404@1|root,COG1404@2|Bacteria,2IZNN@203682|Planctomycetes	203682|Planctomycetes	O	alpha-L-arabinofuranosidase	-	-	-	-	-	-	-	-	-	-	-	-	SBBP
HKD1_k127_774313_17	1122603.ATVI01000010_gene1066	1.647e-92	323.0	COG4102@1|root,COG4102@2|Bacteria,1MX4R@1224|Proteobacteria,1RR99@1236|Gammaproteobacteria,1X41W@135614|Xanthomonadales	135614|Xanthomonadales	S	Protein of unknown function (DUF1501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1501
HKD1_k127_774313_18	1120999.JONM01000013_gene2187	4.187e-92	331.0	COG5267@1|root,COG5267@2|Bacteria,1MWJK@1224|Proteobacteria,2VJD4@28216|Betaproteobacteria	28216|Betaproteobacteria	G	Protein of unknown function (DUF1800)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1800
HKD1_k127_774313_64	573370.DMR_42140	5.492e-09	60.0	COG5336@1|root,COG5336@2|Bacteria,1NHIS@1224|Proteobacteria,42VWC@68525|delta/epsilon subdivisions,2WS5S@28221|Deltaproteobacteria,2MGIG@213115|Desulfovibrionales	28221|Deltaproteobacteria	S	Putative F0F1-ATPase subunit Ca2+/Mg2+ transporter	-	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HKD1_k127_774313_24	435591.BDI_3207	1.59e-68	247.0	COG0535@1|root,COG0535@2|Bacteria,4PA9R@976|Bacteroidetes,2FWDR@200643|Bacteroidia	976|Bacteroidetes	S	Radical SAM superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_774313_36	523791.Kkor_1008	7.063e-42	175.0	COG2132@1|root,COG2132@2|Bacteria,1MU0J@1224|Proteobacteria,1S07F@1236|Gammaproteobacteria	1236|Gammaproteobacteria	Q	Multicopper oxidase	-	-	-	ko:K04753	-	-	-	-	ko00000	-	-	-	Cu-oxidase,Cu-oxidase_2,Cu-oxidase_3
HKD1_k127_774313_14	861299.J421_5995	2.367e-103	364.0	COG0823@1|root,COG3710@1|root,COG0823@2|Bacteria,COG3710@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	AAA_16,Abhydrolase_1,PD40,Trans_reg_C
HKD1_k127_774313_28	743836.AYNA01000104_gene2059	2.27e-57	215.0	COG1215@1|root,COG1215@2|Bacteria,1R8UT@1224|Proteobacteria,2TVQT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3,Glyco_transf_21
HKD1_k127_774313_32	32057.KB217480_gene8266	4.56e-48	177.0	28KW4@1|root,2ZACH@2|Bacteria,1G2SE@1117|Cyanobacteria,1HT4Q@1161|Nostocales	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_57	1403819.BATR01000065_gene1929	6.771e-15	77.0	2CX21@1|root,32T0Y@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_11	234267.Acid_5690	2.981e-124	417.0	COG1007@1|root,COG1007@2|Bacteria,3Y43Y@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_774313_6	234267.Acid_5689	2.309e-150	495.0	COG1008@1|root,COG1008@2|Bacteria,3Y3VX@57723|Acidobacteria	57723|Acidobacteria	C	Proton-conducting membrane transporter	-	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD1_k127_774313_3	945713.IALB_1869	3.072e-171	565.0	COG1009@1|root,COG1009@2|Bacteria	2|Bacteria	CP	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_C,Proton_antipo_M,Proton_antipo_N
HKD1_k127_774313_44	204669.Acid345_1293	4.383e-28	117.0	COG0713@1|root,COG0713@2|Bacteria,3Y54E@57723|Acidobacteria,2JNK4@204432|Acidobacteriia	204432|Acidobacteriia	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 4L	-	-	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD1_k127_774313_47	234267.Acid_5686	5.344e-26	116.0	COG0839@1|root,COG0839@2|Bacteria,3Y5QU@57723|Acidobacteria	57723|Acidobacteria	C	NADH-ubiquinone/plastoquinone oxidoreductase chain 6	-	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD1_k127_774313_37	234267.Acid_5685	8.184e-42	159.0	COG1143@1|root,COG1143@2|Bacteria,3Y529@57723|Acidobacteria	57723|Acidobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	-	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4,Fer4_7
HKD1_k127_774313_15	671143.DAMO_2695	1.214e-99	340.0	COG1005@1|root,COG1005@2|Bacteria,2NNTT@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_774313_5	204669.Acid345_1289	6.064e-158	506.0	COG0649@1|root,COG0649@2|Bacteria,3Y3AB@57723|Acidobacteria,2JKWC@204432|Acidobacteriia	204432|Acidobacteriia	C	Respiratory-chain NADH dehydrogenase, 49 Kd subunit	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_774313_38	1379698.RBG1_1C00001G1052	1.099e-40	162.0	COG0852@1|root,COG0852@2|Bacteria,2NPN6@2323|unclassified Bacteria	2|Bacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	GO:0003674,GO:0003824,GO:0003954,GO:0006091,GO:0006119,GO:0006120,GO:0006139,GO:0006163,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008137,GO:0008150,GO:0008152,GO:0009117,GO:0009123,GO:0009126,GO:0009141,GO:0009144,GO:0009150,GO:0009161,GO:0009167,GO:0009199,GO:0009205,GO:0009259,GO:0009987,GO:0015980,GO:0016310,GO:0016491,GO:0016651,GO:0016655,GO:0017144,GO:0019637,GO:0019693,GO:0022900,GO:0022904,GO:0034641,GO:0042773,GO:0042775,GO:0044237,GO:0044238,GO:0044281,GO:0045333,GO:0046034,GO:0046483,GO:0050136,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:1901135,GO:1901360,GO:1901564	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iAF987.Gmet_3353	Complex1_30kDa
HKD1_k127_774313_43	395493.BegalDRAFT_1852	1.395e-29	118.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,1SCMH@1236|Gammaproteobacteria,461AF@72273|Thiotrichales	72273|Thiotrichales	J	Binds the 23S rRNA	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD1_k127_774313_25	1340493.JNIF01000004_gene264	1.468e-67	247.0	COG3872@1|root,COG3872@2|Bacteria,3Y66K@57723|Acidobacteria	57723|Acidobacteria	S	Protein of unknown function (DUF1385)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1385
HKD1_k127_774313_7	240015.ACP_2651	2.15e-147	475.0	COG0216@1|root,COG0216@2|Bacteria,3Y2N9@57723|Acidobacteria,2JHYH@204432|Acidobacteriia	204432|Acidobacteriia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_774313_1	1232410.KI421413_gene543	6.162e-203	646.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,43BKD@68525|delta/epsilon subdivisions,2WJNK@28221|Deltaproteobacteria,43T3U@69541|Desulfuromonadales	28221|Deltaproteobacteria	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD1_k127_774313_58	1121904.ARBP01000026_gene666	6.852e-15	88.0	COG0457@1|root,COG0457@2|Bacteria	1121904.ARBP01000026_gene666|-	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_41	472759.Nhal_1987	1.041e-32	130.0	COG0610@1|root,COG2852@1|root,COG0610@2|Bacteria,COG2852@2|Bacteria,1MU96@1224|Proteobacteria,1RP2Q@1236|Gammaproteobacteria,1WXDN@135613|Chromatiales	135613|Chromatiales	V	Subunit R is required for both nuclease and ATPase activities, but not for modification	-	-	3.1.21.3	ko:K01153	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	DUF3387,HSDR_N,ResIII
HKD1_k127_774313_66	1173264.KI913949_gene161	4.529e-06	52.0	COG1002@1|root,COG1002@2|Bacteria,1G393@1117|Cyanobacteria,1H6YG@1150|Oscillatoriales	1117|Cyanobacteria	V	methylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_54	448385.sce2762	8.292e-18	85.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,42M4Z@68525|delta/epsilon subdivisions,2WJ0D@28221|Deltaproteobacteria,2YUHW@29|Myxococcales	28221|Deltaproteobacteria	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH-3	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_774313_12	401526.TcarDRAFT_2158	2.645e-122	403.0	COG1063@1|root,COG1063@2|Bacteria,1U5GN@1239|Firmicutes	1239|Firmicutes	E	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_774313_16	1185876.BN8_01991	5.319e-97	323.0	COG1434@1|root,COG1434@2|Bacteria,4NI3S@976|Bacteroidetes,47NUZ@768503|Cytophagia	976|Bacteroidetes	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD1_k127_774313_45	1230343.CANP01000005_gene447	2.035e-27	115.0	COG2105@1|root,COG2105@2|Bacteria,1MZ4Y@1224|Proteobacteria,1SA6T@1236|Gammaproteobacteria,1JEP6@118969|Legionellales	118969|Legionellales	S	Gamma-glutamyl cyclotransferase, AIG2-like	-	-	-	-	-	-	-	-	-	-	-	-	GGACT
HKD1_k127_774313_68	1537917.JU82_03695	0.0001288	50.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2YMM8@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	cation transport ATPase	copA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_774313_31	504728.K649_04355	4.974e-50	182.0	COG0454@1|root,COG0456@2|Bacteria,1WND2@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	K	FR47-like protein	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD1_k127_774313_48	172088.AUGA01000023_gene694	8.829e-25	110.0	COG0454@1|root,COG0456@2|Bacteria,1R6DW@1224|Proteobacteria,2U3QR@28211|Alphaproteobacteria,3JRBT@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD1_k127_774313_34	439235.Dalk_2729	7.69e-46	172.0	COG3809@1|root,COG3809@2|Bacteria,1PZB0@1224|Proteobacteria,433GD@68525|delta/epsilon subdivisions,2WXX5@28221|Deltaproteobacteria,2MP8T@213118|Desulfobacterales	28221|Deltaproteobacteria	S	Transcription factor zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-TFIIB
HKD1_k127_774313_50	1297742.A176_03330	4.56e-20	93.0	COG3860@1|root,COG3860@2|Bacteria,1NB8Z@1224|Proteobacteria,43BAD@68525|delta/epsilon subdivisions,2X6PJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774313_33	926561.KB900617_gene2105	6.683e-48	187.0	COG0438@1|root,COG0438@2|Bacteria,1TPY6@1239|Firmicutes,24834@186801|Clostridia,3WC93@53433|Halanaerobiales	186801|Clostridia	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_774313_59	755732.Fluta_1534	8.656e-15	84.0	COG2227@1|root,COG2227@2|Bacteria,4NGVF@976|Bacteroidetes,1HXGK@117743|Flavobacteriia,2PAS1@246874|Cryomorphaceae	976|Bacteroidetes	H	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_774313_19	1499967.BAYZ01000069_gene1839	1.84e-91	317.0	COG2755@1|root,COG2755@2|Bacteria,2NR42@2323|unclassified Bacteria	2|Bacteria	E	lipolytic protein G-D-S-L family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL,Lipase_GDSL_2
HKD1_k127_774313_2	234267.Acid_3898	1.345e-181	595.0	COG2304@1|root,COG2304@2|Bacteria,3Y3DR@57723|Acidobacteria	2|Bacteria	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,VWA,VWA_2
HKD1_k127_774313_13	278963.ATWD01000002_gene340	3.229e-119	396.0	COG0438@1|root,COG0438@2|Bacteria,3Y3CI@57723|Acidobacteria,2JKK7@204432|Acidobacteriia	204432|Acidobacteriia	M	glycosyl transferase group 1	-	-	-	ko:K00754	-	-	-	-	ko00000,ko01000	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_774313_4	1267535.KB906767_gene1129	8.439e-164	551.0	COG0515@1|root,COG0515@2|Bacteria,3Y4IC@57723|Acidobacteria,2JJ7M@204432|Acidobacteriia	204432|Acidobacteriia	KLT	Protein kinase domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase
HKD1_k127_774313_27	502025.Hoch_1576	1.189e-59	212.0	COG1595@1|root,COG1595@2|Bacteria,1RINW@1224|Proteobacteria,4385N@68525|delta/epsilon subdivisions,2X3FI@28221|Deltaproteobacteria,2YVVV@29|Myxococcales	28221|Deltaproteobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_774313_26	1304885.AUEY01000096_gene2839	5.229e-61	239.0	COG1404@1|root,COG2304@1|root,COG2911@1|root,COG3897@1|root,COG5434@1|root,COG1404@2|Bacteria,COG2304@2|Bacteria,COG2911@2|Bacteria,COG3897@2|Bacteria,COG5434@2|Bacteria,1P8N9@1224|Proteobacteria,43DXZ@68525|delta/epsilon subdivisions,2X72D@28221|Deltaproteobacteria,2MNHJ@213118|Desulfobacterales	28221|Deltaproteobacteria	E	alginic acid biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	DUF1573
HKD1_k127_7807798_5	234267.Acid_1539	2.035e-89	302.0	COG0457@1|root,COG0457@2|Bacteria,3Y3PD@57723|Acidobacteria	57723|Acidobacteria	S	Peptidase family M49	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M49
HKD1_k127_7807798_8	1173028.ANKO01000227_gene1244	7.078e-43	163.0	COG4636@1|root,COG4636@2|Bacteria,1G269@1117|Cyanobacteria,1H7IE@1150|Oscillatoriales	1117|Cyanobacteria	S	Putative restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Uma2
HKD1_k127_7807798_2	1454004.AW11_01665	2.059e-172	554.0	COG2301@1|root,COG2301@2|Bacteria,1R7U2@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the HpcH HpaI aldolase family	-	-	-	-	-	-	-	-	-	-	-	-	HpcH_HpaI
HKD1_k127_7807798_15	1122176.KB903576_gene5002	2.357e-17	97.0	COG1361@1|root,COG3291@1|root,COG1361@2|Bacteria,COG3291@2|Bacteria,4NYN2@976|Bacteroidetes	976|Bacteroidetes	G	Reprolysin (M12B) family zinc metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	PKD,Reprolysin_5
HKD1_k127_7807798_3	1123508.JH636453_gene5827	1.916e-117	422.0	COG4447@1|root,COG5276@1|root,COG4447@2|Bacteria,COG5276@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	ko:K13735	ko05100,map05100	-	-	-	ko00000,ko00001	-	-	-	Big_2,DUF1566,DUF4347,He_PIG
HKD1_k127_7807798_17	1038866.KB902829_gene1782	1.178e-09	73.0	COG1749@1|root,COG2133@1|root,COG3209@1|root,COG1749@2|Bacteria,COG2133@2|Bacteria,COG3209@2|Bacteria,1PF7U@1224|Proteobacteria,2V8VD@28211|Alphaproteobacteria,3K3RC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	GN	Glucose / Sorbosone dehydrogenase	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	Calx-beta,DUF4082,GSDH
HKD1_k127_7807798_13	204669.Acid345_2692	1.579e-19	102.0	COG1196@1|root,COG1196@2|Bacteria	2|Bacteria	D	nuclear chromosome segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7807798_16	324925.Ppha_2262	1.16e-12	78.0	2ER1C@1|root,33IKW@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7807798_4	350688.Clos_2654	7.679e-104	353.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	-	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_7807798_7	1487953.JMKF01000015_gene6227	2.452e-63	221.0	COG1670@1|root,COG1670@2|Bacteria,1G6XM@1117|Cyanobacteria,1HCHH@1150|Oscillatoriales	1117|Cyanobacteria	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_7807798_9	472759.Nhal_2071	2.842e-42	164.0	COG2121@1|root,COG2121@2|Bacteria,1MZID@1224|Proteobacteria,1SEZZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Domain of unknown function (DUF374)	-	-	-	ko:K09778	-	-	-	-	ko00000	-	-	-	DUF374
HKD1_k127_7807798_6	682795.AciX8_3399	1.006e-69	248.0	COG1560@1|root,COG1560@2|Bacteria,3Y2RW@57723|Acidobacteria,2JIMS@204432|Acidobacteriia	204432|Acidobacteriia	M	lipid A biosynthesis acyltransferase	-	-	2.3.1.241	ko:K02517	ko00540,ko01100,map00540,map01100	M00060	R05146	RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Lip_A_acyltrans
HKD1_k127_7807798_14	714943.Mucpa_3516	5.222e-19	97.0	COG2172@1|root,COG2172@2|Bacteria,4NRAA@976|Bacteroidetes,1IT0C@117747|Sphingobacteriia	976|Bacteroidetes	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	rsbW	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HKD1_k127_7807798_1	272134.KB731324_gene3218	7.45e-173	571.0	COG5001@1|root,COG5001@2|Bacteria,1G0SY@1117|Cyanobacteria,1H7V4@1150|Oscillatoriales	1117|Cyanobacteria	T	signal transduction protein containing a membrane domain an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,MHYT,PAS,PAS_3,PAS_9
HKD1_k127_7807798_12	1206741.BAFX01000101_gene1512	9.835e-21	103.0	COG3393@1|root,COG3393@2|Bacteria,2GMD2@201174|Actinobacteria,4FU66@85025|Nocardiaceae	201174|Actinobacteria	S	Domain of unknown function (DUF4081)	-	-	-	ko:K06976	-	-	-	-	ko00000	-	-	-	Acetyltransf_1,DUF4081,FR47
HKD1_k127_7807798_11	43989.cce_3041	1.444e-26	120.0	COG3000@1|root,COG3000@2|Bacteria	2|Bacteria	I	iron ion binding	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD1_k127_7807798_0	903818.KI912268_gene2246	5.985e-257	814.0	COG0542@1|root,COG0542@2|Bacteria,3Y35D@57723|Acidobacteria	57723|Acidobacteria	O	Belongs to the ClpA ClpB family	-	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_7807798_10	204669.Acid345_0248	1.616e-40	163.0	COG4775@1|root,COG4775@2|Bacteria,3Y2Q9@57723|Acidobacteria,2JHYD@204432|Acidobacteriia	204432|Acidobacteriia	M	TIGRFAM outer membrane protein assembly complex, YaeT protein	-	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD1_k127_7833266_1	1267535.KB906767_gene3964	1.041e-16	86.0	COG3209@1|root,COG3209@2|Bacteria,3Y7FC@57723|Acidobacteria,2JKK9@204432|Acidobacteriia	204432|Acidobacteriia	M	COG3209 Rhs family protein	-	-	-	-	-	-	-	-	-	-	-	-	RHS_repeat
HKD1_k127_7833266_0	768671.ThimaDRAFT_4426	1.323e-47	191.0	COG1321@1|root,COG1321@2|Bacteria,1N8WG@1224|Proteobacteria,1SQA0@1236|Gammaproteobacteria,1X16W@135613|Chromatiales	1224|Proteobacteria	K	iron dependent repressor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7833266_2	1123399.AQVE01000046_gene2868	2.743e-10	66.0	COG3209@1|root,COG3209@2|Bacteria,1MVV1@1224|Proteobacteria,1RP75@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	rhs family	-	-	-	-	-	-	-	-	-	-	-	-	DUF11,RHS,RHS_repeat
HKD1_k127_7847424_4	234267.Acid_7677	4.881e-61	216.0	COG1595@1|root,COG1595@2|Bacteria,3Y7UW@57723|Acidobacteria	57723|Acidobacteria	K	ECF sigma factor	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_ECF
HKD1_k127_7847424_2	1379698.RBG1_1C00001G0607	2.235e-114	401.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,2NQNE@2323|unclassified Bacteria	2|Bacteria	T	Serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase,TPR_2,TPR_8
HKD1_k127_7847424_3	1121091.AUMP01000020_gene3682	5.656e-114	383.0	COG0515@1|root,COG0515@2|Bacteria,1VDRS@1239|Firmicutes,4HM2A@91061|Bacilli	91061|Bacilli	KLT	Protein kinase domain	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD1_k127_7847424_1	512565.AMIS_48540	4.643e-119	399.0	COG1652@1|root,COG1652@2|Bacteria	2|Bacteria	S	positive regulation of growth rate	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,LysM
HKD1_k127_7847424_6	555779.Dthio_PD0143	2.155e-14	74.0	2DPSP@1|root,33387@2|Bacteria	2|Bacteria	S	23S rRNA-intervening sequence protein	-	-	-	-	-	-	-	-	-	-	-	-	23S_rRNA_IVP
HKD1_k127_7847424_0	204669.Acid345_3257	8.022e-139	454.0	COG4867@1|root,COG4867@2|Bacteria,3Y2VU@57723|Acidobacteria,2JHSR@204432|Acidobacteriia	204432|Acidobacteriia	S	von Willebrand factor (vWF) type A domain	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA_2
HKD1_k127_7847424_7	1123278.KB893388_gene5676	1.3e-10	63.0	COG0614@1|root,COG0614@2|Bacteria,4NTHD@976|Bacteroidetes,47QBE@768503|Cytophagia	976|Bacteroidetes	P	PD-(D/E)XK nuclease superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PDDEXK_3
HKD1_k127_7927916_12	1444310.JANV01000095_gene3186	9.003e-13	78.0	COG1376@1|root,COG3409@1|root,COG1376@2|Bacteria,COG3409@2|Bacteria,1V6J2@1239|Firmicutes,4HJZH@91061|Bacilli,1ZBKG@1386|Bacillus	91061|Bacilli	O	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1,YkuD
HKD1_k127_7927916_5	697282.Mettu_0792	7.221e-63	226.0	COG3179@1|root,COG3179@2|Bacteria,1RC1P@1224|Proteobacteria,1RN66@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	PFAM glycoside hydrolase family 19	-	-	-	ko:K03791	-	-	-	-	ko00000	-	GH19	-	Glyco_hydro_19
HKD1_k127_7927916_10	489825.LYNGBM3L_02320	4.19e-31	131.0	COG3409@1|root,COG3409@2|Bacteria,1GECI@1117|Cyanobacteria,1HFST@1150|Oscillatoriales	1117|Cyanobacteria	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_7927916_4	196490.AUEZ01000003_gene3863	6.728e-109	368.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria,3JTSC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_7927916_6	234267.Acid_6539	4.707e-49	184.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria	57723|Acidobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_7927916_7	204669.Acid345_3454	1.893e-48	182.0	COG2930@1|root,COG2930@2|Bacteria,3Y2F0@57723|Acidobacteria,2JIT6@204432|Acidobacteriia	204432|Acidobacteriia	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD1_k127_7927916_2	204669.Acid345_1269	6.236e-174	553.0	COG0404@1|root,COG0404@2|Bacteria,3Y3IU@57723|Acidobacteria,2JI8G@204432|Acidobacteriia	2|Bacteria	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD1_k127_7927916_3	1267533.KB906741_gene405	4.284e-138	448.0	COG4638@1|root,COG4638@2|Bacteria,3Y547@57723|Acidobacteria,2JNCI@204432|Acidobacteriia	204432|Acidobacteriia	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	ko:K00479	-	-	-	-	ko00000	-	-	-	Rieske,Ring_hydroxyl_A
HKD1_k127_7927916_9	1089547.KB913013_gene1792	1.545e-31	130.0	2DR2Z@1|root,339YC@2|Bacteria,4P4XI@976|Bacteroidetes,47VKU@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3828
HKD1_k127_7927916_13	240015.ACP_0645	0.0006317	43.0	COG1943@1|root,COG1943@2|Bacteria,3Y4PK@57723|Acidobacteria,2JJBM@204432|Acidobacteriia	204432|Acidobacteriia	L	Transposase IS200 like	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_7927916_1	247490.KSU1_C1626	2.322e-212	677.0	COG1966@1|root,COG1966@2|Bacteria,2IWZE@203682|Planctomycetes	203682|Planctomycetes	T	Carbon starvation protein	cstA	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD1_k127_7927916_0	204669.Acid345_1918	0.0	1233.0	COG3808@1|root,COG3808@2|Bacteria,3Y34E@57723|Acidobacteria,2JJHT@204432|Acidobacteriia	204432|Acidobacteriia	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD1_k127_7927916_11	1089550.ATTH01000001_gene1141	8.065e-17	90.0	COG0589@1|root,COG0589@2|Bacteria,4NFZ5@976|Bacteroidetes,1FK0T@1100069|Bacteroidetes Order II. Incertae sedis	976|Bacteroidetes	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_7927916_8	1382356.JQMP01000001_gene1206	2.008e-44	168.0	COG1268@1|root,COG1268@2|Bacteria,2GBUZ@200795|Chloroflexi,27YWE@189775|Thermomicrobia	189775|Thermomicrobia	S	BioY family	-	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
HKD1_k127_7948185_16	880072.Desac_2741	1.794e-56	211.0	COG0265@1|root,COG0457@1|root,COG0265@2|Bacteria,COG0457@2|Bacteria,1NE6G@1224|Proteobacteria,4321S@68525|delta/epsilon subdivisions,2WWD7@28221|Deltaproteobacteria	28221|Deltaproteobacteria	O	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD1_k127_7948185_32	525367.HMPREF0556_11338	7.955e-10	69.0	COG0791@1|root,COG3883@1|root,COG0791@2|Bacteria,COG3883@2|Bacteria,1UVYK@1239|Firmicutes,4HDAX@91061|Bacilli,26K09@186820|Listeriaceae	91061|Bacilli	M	Peptidase P60	spl	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	NLPC_P60
HKD1_k127_7948185_18	1254432.SCE1572_04190	4.163e-49	179.0	COG0727@1|root,COG0727@2|Bacteria,1N5PC@1224|Proteobacteria	1224|Proteobacteria	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_7948185_5	251221.35211608	8.071e-156	500.0	COG1899@1|root,COG1899@2|Bacteria,1G448@1117|Cyanobacteria	1117|Cyanobacteria	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD1_k127_7948185_37	1298863.AUEP01000015_gene1789	0.0007647	44.0	2E3JZ@1|root,32YI8@2|Bacteria,2GQIX@201174|Actinobacteria,4DS7G@85009|Propionibacteriales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4177
HKD1_k127_7948185_33	1461577.CCMH01000005_gene1888	1.494e-07	56.0	2EF83@1|root,33912@2|Bacteria,4NWNU@976|Bacteroidetes,1IID6@117743|Flavobacteriia	976|Bacteroidetes	S	Cysteine-rich CWC	-	-	-	-	-	-	-	-	-	-	-	-	Cys_rich_CWC
HKD1_k127_7948185_15	1047013.AQSP01000057_gene1926	2.594e-60	225.0	COG1253@1|root,COG1253@2|Bacteria,2NP9I@2323|unclassified Bacteria	2|Bacteria	S	Transporter associated domain	gldE	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_7948185_27	1131269.AQVV01000001_gene1296	3.068e-21	99.0	COG0319@1|root,COG0319@2|Bacteria	2|Bacteria	C	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	GO:0000469,GO:0000478,GO:0003674,GO:0003824,GO:0004518,GO:0004519,GO:0004521,GO:0004540,GO:0005488,GO:0006139,GO:0006355,GO:0006364,GO:0006396,GO:0006412,GO:0006518,GO:0006725,GO:0006807,GO:0006950,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009987,GO:0010467,GO:0010468,GO:0010556,GO:0016070,GO:0016072,GO:0016151,GO:0016787,GO:0016788,GO:0016892,GO:0016894,GO:0019219,GO:0019222,GO:0019538,GO:0022613,GO:0030490,GO:0031323,GO:0031326,GO:0031554,GO:0031564,GO:0034470,GO:0034641,GO:0034645,GO:0034660,GO:0042254,GO:0042274,GO:0043043,GO:0043167,GO:0043169,GO:0043170,GO:0043244,GO:0043603,GO:0043604,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0046483,GO:0046872,GO:0046914,GO:0050789,GO:0050794,GO:0050896,GO:0051128,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0071704,GO:0071840,GO:0080090,GO:0090304,GO:0090305,GO:0090501,GO:0090502,GO:0140098,GO:1901360,GO:1901564,GO:1901566,GO:1901576,GO:1903506,GO:2000112,GO:2001141	2.6.99.2,3.5.4.5	ko:K01489,ko:K03474,ko:K03595,ko:K07042	ko00240,ko00750,ko00983,ko01100,map00240,map00750,map00983,map01100	M00124	R01878,R02485,R05838,R08221	RC00074,RC00514,RC01476	ko00000,ko00001,ko00002,ko01000,ko03009,ko03029	-	-	-	UPF0054
HKD1_k127_7948185_7	204669.Acid345_3538	7.848e-114	375.0	COG1702@1|root,COG1702@2|Bacteria,3Y3RM@57723|Acidobacteria,2JI4V@204432|Acidobacteriia	204432|Acidobacteriia	T	PhoH-like protein	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD1_k127_7948185_20	344747.PM8797T_00177	4.901e-34	145.0	2ESRG@1|root,33K9V@2|Bacteria,2J33K@203682|Planctomycetes	203682|Planctomycetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7948185_24	743719.PaelaDRAFT_0620	8.463e-26	111.0	28Z5Z@1|root,2ZKY9@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7948185_0	861299.J421_3669	0.0	1086.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	Sortilin-Vps10
HKD1_k127_7948185_34	1121957.ATVL01000010_gene552	1.44e-05	53.0	2CG2C@1|root,3396W@2|Bacteria,4NWWU@976|Bacteroidetes,47S7F@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7948185_2	861299.J421_0989	6.51e-265	832.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1ZSZA@142182|Gemmatimonadetes	142182|Gemmatimonadetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD1_k127_7948185_30	391587.KAOT1_06617	2.521e-14	79.0	COG5649@1|root,COG5649@2|Bacteria,4NPG5@976|Bacteroidetes,1I4MN@117743|Flavobacteriia	976|Bacteroidetes	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD1_k127_7948185_21	278963.ATWD01000001_gene4299	3.957e-32	145.0	COG2304@1|root,COG2304@2|Bacteria,3Y3ER@57723|Acidobacteria,2JKG4@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7948185_14	86416.Clopa_2530	2.257e-64	227.0	COG1794@1|root,COG1794@2|Bacteria,1TR3U@1239|Firmicutes,24ADY@186801|Clostridia,36G2E@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the aspartate glutamate racemases family	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS14520	Asp_Glu_race
HKD1_k127_7948185_3	1382359.JIAL01000001_gene1418	1.531e-248	788.0	COG2936@1|root,COG2936@2|Bacteria,3Y33N@57723|Acidobacteria,2JIAP@204432|Acidobacteriia	204432|Acidobacteriia	S	Hydrolase CocE NonD family	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HKD1_k127_7948185_1	234267.Acid_7599	2.059e-280	894.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HKD1_k127_7948185_25	1121033.AUCF01000005_gene5295	7.026e-25	109.0	2CTAY@1|root,32ST0@2|Bacteria,1N57M@1224|Proteobacteria,2UDXZ@28211|Alphaproteobacteria,2JTMY@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7948185_8	483219.LILAB_25815	1.671e-113	377.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,4304Z@68525|delta/epsilon subdivisions,2WVJ8@28221|Deltaproteobacteria,2YV3F@29|Myxococcales	28221|Deltaproteobacteria	L	Eukaryotic DNA topoisomerase I, catalytic core	topI	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD1_k127_7948185_19	204669.Acid345_1801	4.098e-42	158.0	COG5478@1|root,COG5478@2|Bacteria,3Y898@57723|Acidobacteria,2JN9V@204432|Acidobacteriia	204432|Acidobacteriia	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD1_k127_7948185_9	1163408.UU9_07109	3.778e-112	374.0	COG0668@1|root,COG0668@2|Bacteria,1PMY3@1224|Proteobacteria	1224|Proteobacteria	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD1_k127_7948185_4	448385.sce8781	4.538e-193	620.0	COG1387@1|root,COG1796@1|root,COG1387@2|Bacteria,COG1796@2|Bacteria,1MYXV@1224|Proteobacteria,42MQX@68525|delta/epsilon subdivisions,2WKUP@28221|Deltaproteobacteria,2YXCT@29|Myxococcales	28221|Deltaproteobacteria	L	DNA polymerase beta thumb	-	-	-	ko:K02347	-	-	-	-	ko00000,ko03400	-	-	-	DNA_pol_B_palm,DNA_pol_B_thumb,HHH_5,HHH_8,PHP
HKD1_k127_7948185_26	102129.Lepto7375DRAFT_4225	8.137e-22	101.0	COG1943@1|root,COG1943@2|Bacteria,1G6SS@1117|Cyanobacteria,1HBRS@1150|Oscillatoriales	1117|Cyanobacteria	L	PFAM Transposase	-	-	-	ko:K07491	-	-	-	-	ko00000	-	-	-	Y1_Tnp
HKD1_k127_7948185_13	1237149.C900_00072	2.081e-80	278.0	COG1273@1|root,COG1273@2|Bacteria,4NHHQ@976|Bacteroidetes,47PE5@768503|Cytophagia	976|Bacteroidetes	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD1_k127_7948185_17	391625.PPSIR1_33781	1.343e-53	210.0	COG0515@1|root,COG0515@2|Bacteria,1MV1P@1224|Proteobacteria,42Q67@68525|delta/epsilon subdivisions,2WKZ1@28221|Deltaproteobacteria,2YUQ6@29|Myxococcales	28221|Deltaproteobacteria	KLT	serine threonine protein kinase	-	-	2.7.11.1	ko:K08884,ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	AAA_16,Pkinase,TPR_12,zinc_ribbon_2
HKD1_k127_7948185_10	886293.Sinac_0554	1.793e-109	368.0	COG0515@1|root,COG1716@1|root,COG0515@2|Bacteria,COG1716@2|Bacteria,2J2EJ@203682|Planctomycetes	203682|Planctomycetes	KLT	Forkhead associated domain	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	FHA,Pkinase
HKD1_k127_7948185_12	401053.AciPR4_0595	8.77e-97	339.0	COG0793@1|root,COG0793@2|Bacteria,3Y3KP@57723|Acidobacteria,2JHNE@204432|Acidobacteriia	204432|Acidobacteriia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_7948185_36	1123075.AUDP01000016_gene3411	0.0003772	48.0	COG1396@1|root,COG1396@2|Bacteria	2|Bacteria	K	sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_19,HTH_3,HTH_31
HKD1_k127_7948185_23	240015.ACP_3265	7.163e-27	117.0	COG2856@1|root,COG2856@2|Bacteria	2|Bacteria	E	Zn peptidase	irrE	-	-	ko:K21686	-	-	-	-	ko00000,ko03000	-	-	-	DUF4344,Peptidase_M78
HKD1_k127_7948185_11	1379698.RBG1_1C00001G1345	1.243e-99	340.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2NQ3V@2323|unclassified Bacteria	2|Bacteria	KT	COGs COG2208 Serine phosphatase RsbU regulator of sigma subunit	rsbU	-	3.1.3.3,4.6.1.1	ko:K01768,ko:K07315	ko00230,ko02025,ko04113,ko04213,map00230,map02025,map04113,map04213	M00695	R00089,R00434	RC00295	ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	GAF,GAF_2,HATPase_c_2,SSF,SpoIIE
HKD1_k127_7948185_6	204669.Acid345_0689	3.813e-144	468.0	COG2805@1|root,COG2805@2|Bacteria,3Y316@57723|Acidobacteria,2JIT4@204432|Acidobacteriia	204432|Acidobacteriia	NU	Type II/IV secretion system protein	-	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_7948185_35	204669.Acid345_0913	2.112e-05	57.0	COG2304@1|root,COG2304@2|Bacteria,3Y98A@57723|Acidobacteria,2JP4V@204432|Acidobacteriia	204432|Acidobacteriia	S	oxidoreductase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7948185_22	234267.Acid_6308	5.539e-28	126.0	COG2304@1|root,COG2304@2|Bacteria,3Y2PC@57723|Acidobacteria	57723|Acidobacteria	S	von Willebrand factor, type A	-	-	-	-	-	-	-	-	-	-	-	-	VWA,VWA_2
HKD1_k127_7948185_29	1340493.JNIF01000004_gene73	3.765e-17	93.0	COG3712@1|root,COG3712@2|Bacteria,3Y5MB@57723|Acidobacteria	57723|Acidobacteria	PT	iron ion homeostasis	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD1_k127_7948185_28	390874.Tpet_0162	5.351e-20	94.0	COG1725@1|root,COG1725@2|Bacteria,2GDGX@200918|Thermotogae	200918|Thermotogae	K	PFAM regulatory protein GntR HTH	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD1_k127_7948185_31	379066.GAU_3508	4.035e-10	64.0	COG4584@1|root,COG4584@2|Bacteria,1ZV8R@142182|Gemmatimonadetes	142182|Gemmatimonadetes	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	rve
HKD1_k127_8001695_1	234267.Acid_3225	2.305e-80	289.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria	2|Bacteria	S	cAMP biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	TPR_11,TPR_16,TPR_19,TPR_8,Trans_reg_C
HKD1_k127_8001695_0	1121459.AQXE01000009_gene554	8.6e-116	385.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,42M5V@68525|delta/epsilon subdivisions,2WIR6@28221|Deltaproteobacteria,2M92B@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine	nifS-1	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_867201_13	234267.Acid_1366	4.009e-18	84.0	COG0535@1|root,COG0535@2|Bacteria	2|Bacteria	I	radical SAM domain protein	pqqC	-	1.3.3.11	ko:K06137,ko:K06138	-	-	-	-	ko00000,ko01000	-	-	-	Fer4_12,Fer4_14,PqqD,Radical_SAM,SPASM,TENA_THI-4
HKD1_k127_867201_12	1278073.MYSTI_03701	1.636e-20	97.0	COG2204@1|root,COG2204@2|Bacteria	2|Bacteria	T	phosphorelay signal transduction system	phcR	-	-	ko:K19622	ko02020,map02020	-	-	-	ko00000,ko00001,ko02022	-	-	-	HATPase_c,HDOD,Response_reg
HKD1_k127_867201_1	204669.Acid345_3017	9.987e-172	550.0	COG2204@1|root,COG2204@2|Bacteria,3Y38J@57723|Acidobacteria,2JICQ@204432|Acidobacteriia	57723|Acidobacteria	T	PFAM Response regulator receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_867201_7	1144275.COCOR_03677	2.298e-95	340.0	COG2202@1|root,COG3852@1|root,COG2202@2|Bacteria,COG3852@2|Bacteria,1NWNJ@1224|Proteobacteria	1224|Proteobacteria	T	PAS domain containing protein	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_8,PAS_9,SBP_bac_3
HKD1_k127_867201_14	215803.DB30_6263	5.918e-11	76.0	COG0745@1|root,COG0745@2|Bacteria,1NBDV@1224|Proteobacteria,434KA@68525|delta/epsilon subdivisions,2WYXM@28221|Deltaproteobacteria,2Z0VC@29|Myxococcales	28221|Deltaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_867201_2	59374.Fisuc_2256	8.46e-150	479.0	COG0451@1|root,COG0451@2|Bacteria	2|Bacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	uxs	-	4.1.1.35,4.2.1.46	ko:K01710,ko:K08678	ko00520,ko00521,ko00523,ko00525,ko01055,ko01100,ko01130,map00520,map00521,map00523,map00525,map01055,map01100,map01130	M00361,M00793	R01384,R06513	RC00402,RC00508	ko00000,ko00001,ko00002,ko01000	-	-	-	GDP_Man_Dehyd
HKD1_k127_867201_9	644282.Deba_1067	3.95e-71	256.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,42NB5@68525|delta/epsilon subdivisions,2WJGX@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	histidine kinase HAMP region domain protein	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,sCache_like
HKD1_k127_867201_10	457412.RSAG_00716	5.184e-54	198.0	COG0745@1|root,COG0745@2|Bacteria,1TQY9@1239|Firmicutes,24EFS@186801|Clostridia,3WRPD@541000|Ruminococcaceae	186801|Clostridia	T	Transcriptional regulatory protein, C terminal	-	-	-	ko:K07658	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_867201_4	204669.Acid345_3131	8.034e-124	406.0	COG0306@1|root,COG0306@2|Bacteria,3Y3ZW@57723|Acidobacteria,2JIZT@204432|Acidobacteriia	204432|Acidobacteriia	P	PFAM phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD1_k127_867201_11	909663.KI867150_gene253	5.829e-47	177.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,42QWG@68525|delta/epsilon subdivisions,2WMS0@28221|Deltaproteobacteria,2MSIV@213462|Syntrophobacterales	28221|Deltaproteobacteria	P	PhoU domain	phoU	-	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_867201_5	1304888.ATWF01000001_gene1833	1.739e-100	334.0	COG1117@1|root,COG1117@2|Bacteria,2GF94@200930|Deferribacteres	200930|Deferribacteres	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_867201_8	649747.HMPREF0083_00885	4.885e-85	289.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4HAKF@91061|Bacilli,26U7E@186822|Paenibacillaceae	91061|Bacilli	P	Phosphate transport system permease	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_867201_6	1191523.MROS_2639	3.212e-99	334.0	COG0573@1|root,COG0573@2|Bacteria	2|Bacteria	P	inorganic phosphate transmembrane transporter activity	pstC	GO:0008150,GO:0040007,GO:0044110,GO:0044116,GO:0044117,GO:0044403,GO:0044419,GO:0051704	-	ko:K02037,ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	iAF987.Gmet_2702	BPD_transp_1
HKD1_k127_867201_3	867903.ThesuDRAFT_01219	5.046e-131	428.0	COG0226@1|root,COG0226@2|Bacteria,1UFGH@1239|Firmicutes,24D85@186801|Clostridia,3WDS1@538999|Clostridiales incertae sedis	186801|Clostridia	P	TIGRFAM phosphate ABC transporter, phosphate-binding protein	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD1_k127_867201_15	269799.Gmet_1462	1.519e-07	64.0	COG3746@1|root,COG3746@2|Bacteria,1MV8P@1224|Proteobacteria,42VG8@68525|delta/epsilon subdivisions,2WSEH@28221|Deltaproteobacteria	28221|Deltaproteobacteria	P	Putative porin	-	-	-	-	-	-	-	-	-	-	-	-	Porin_5
HKD1_k127_867201_0	1340493.JNIF01000004_gene626	7.363e-312	996.0	COG1629@1|root,COG4771@2|Bacteria,3Y6GV@57723|Acidobacteria	57723|Acidobacteria	P	Carboxypeptidase regulatory-like domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,TonB_dep_Rec
HKD1_k127_905437_5	1357275.AVEL02000044_gene372	4.688e-23	100.0	COG1129@1|root,COG1129@2|Bacteria,1MU22@1224|Proteobacteria,1RMCH@1236|Gammaproteobacteria,1Z4MN@136849|Pseudomonas syringae group	1236|Gammaproteobacteria	P	Part of an ABC transporter complex involved in carbohydrate import. Could be involved in ribose, galactose and or methyl galactoside import. Responsible for energy coupling to the transport system	-	-	-	ko:K17215	ko02010,map02010	M00593	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_905437_3	661478.OP10G_1297	4.693e-117	385.0	COG1879@1|root,COG1879@2|Bacteria	2|Bacteria	G	ABC-type sugar transport system periplasmic component	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD1_k127_905437_1	204669.Acid345_0904	1.365e-213	673.0	COG1070@1|root,COG1070@2|Bacteria,3Y2V6@57723|Acidobacteria,2JJ35@204432|Acidobacteriia	204432|Acidobacteriia	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_905437_2	485918.Cpin_5505	1.162e-157	507.0	COG4225@1|root,COG4225@2|Bacteria,4NFWI@976|Bacteroidetes,1IP2G@117747|Sphingobacteriia	976|Bacteroidetes	S	PFAM Glycosyl Hydrolase Family 88	-	-	3.2.1.172	ko:K15532	-	-	-	-	ko00000,ko01000	-	GH105	-	Glyco_hydro_88
HKD1_k127_905437_4	926556.Echvi_4008	5.908e-65	239.0	COG4677@1|root,COG4677@2|Bacteria,4NF12@976|Bacteroidetes,47MK7@768503|Cytophagia	976|Bacteroidetes	G	Domain of unknown function (DUF4861)	-	-	3.1.1.11	ko:K01051	ko00040,ko01100,map00040,map01100	M00081	R02362	RC00460,RC00461	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4861,Glyco_hydro_88
HKD1_k127_905437_0	700598.Niako_5304	1.763e-233	733.0	COG3507@1|root,COG3507@2|Bacteria,4NFXE@976|Bacteroidetes,1IR2U@117747|Sphingobacteriia	976|Bacteroidetes	G	Belongs to the glycosyl hydrolase 43 family	xynBA	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD1_k127_917780_11	765952.PUV_21100	2.731e-05	51.0	COG0169@1|root,COG0710@1|root,COG1670@1|root,COG0169@2|Bacteria,COG0710@2|Bacteria,COG1670@2|Bacteria,2JFIF@204428|Chlamydiae	204428|Chlamydiae	E	Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	GO:0000166,GO:0003674,GO:0003824,GO:0003855,GO:0004764,GO:0005488,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016491,GO:0016614,GO:0016616,GO:0016829,GO:0016835,GO:0016836,GO:0019632,GO:0019752,GO:0032787,GO:0036094,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0048037,GO:0050661,GO:0050662,GO:0055114,GO:0071704,GO:0097159,GO:1901265,GO:1901363,GO:1901576,GO:1901615	1.1.1.25,4.2.1.10	ko:K13832	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413,R03084	RC00206,RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I,Shikimate_DH,Shikimate_dh_N
HKD1_k127_917780_4	234267.Acid_2809	1.111e-71	252.0	COG0566@1|root,COG0566@2|Bacteria,3Y3XM@57723|Acidobacteria	57723|Acidobacteria	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD1_k127_917780_5	1173023.KE650771_gene5107	1.516e-59	215.0	COG1432@1|root,COG1432@2|Bacteria,1G3J6@1117|Cyanobacteria,1JHFM@1189|Stigonemataceae	1117|Cyanobacteria	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN
HKD1_k127_917780_1	562970.Btus_2368	8.655e-135	439.0	COG0372@1|root,COG0372@2|Bacteria,1TPPS@1239|Firmicutes,4H9YE@91061|Bacilli,278TC@186823|Alicyclobacillaceae	91061|Bacilli	C	Citrate synthase, C-terminal domain	citZ	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_917780_6	667014.Thein_2162	1.571e-59	220.0	COG1912@1|root,COG1912@2|Bacteria,2GHAQ@200940|Thermodesulfobacteria	200940|Thermodesulfobacteria	S	S-adenosyl-l-methionine hydroxide adenosyltransferase	-	-	-	ko:K22205	-	-	-	-	ko00000,ko01000	-	-	-	SAM_adeno_trans
HKD1_k127_917780_9	1267535.KB906767_gene290	8.891e-12	76.0	COG2948@1|root,COG2948@2|Bacteria,3Y6SY@57723|Acidobacteria	57723|Acidobacteria	U	multi-organism process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_917780_2	871968.DESME_10735	7.175e-126	414.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,25ZZ7@186807|Peptococcaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_917780_7	1125863.JAFN01000001_gene2666	5.795e-27	113.0	COG0694@1|root,COG0822@1|root,COG0694@2|Bacteria,COG0822@2|Bacteria,1RD5K@1224|Proteobacteria,42MT6@68525|delta/epsilon subdivisions,2WJBU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	CO	May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins	nifU	-	-	ko:K13819	-	-	-	-	ko00000	-	-	-	Fer2_BFD,NifU,NifU_N
HKD1_k127_917780_3	926550.CLDAP_32500	1.703e-116	388.0	COG0026@1|root,COG0026@2|Bacteria,2G7GU@200795|Chloroflexi	200795|Chloroflexi	F	ATP-grasp domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_917780_8	1121456.ATVA01000002_gene3214	8.479e-14	76.0	COG2703@1|root,COG2703@2|Bacteria,1N8CS@1224|Proteobacteria,42VDH@68525|delta/epsilon subdivisions,2X5TX@28221|Deltaproteobacteria,2MCV6@213115|Desulfovibrionales	28221|Deltaproteobacteria	P	PFAM Hemerythrin HHE cation binding domain protein	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HKD1_k127_917780_10	760117.JN27_20445	1.183e-10	71.0	28I2Y@1|root,2Z86X@2|Bacteria,1NDCI@1224|Proteobacteria,2VZHZ@28216|Betaproteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_944224_9	1216932.CM240_0802	6.644e-28	118.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,36E9R@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
HKD1_k127_944224_4	1449049.JONW01000008_gene530	2.308e-61	224.0	2C804@1|root,32VPI@2|Bacteria,1P2IC@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_944224_0	234267.Acid_1582	0.0	1056.0	COG2936@1|root,COG2936@2|Bacteria,3Y684@57723|Acidobacteria	57723|Acidobacteria	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HKD1_k127_944224_1	661478.OP10G_1148	5.834e-307	978.0	COG4447@1|root,COG4447@2|Bacteria	2|Bacteria	S	cellulose binding	-	-	-	-	-	-	-	-	-	-	-	-	BNR,Sortilin-Vps10
HKD1_k127_944224_2	1267533.KB906735_gene4448	5.414e-214	698.0	COG0457@1|root,COG0515@1|root,COG0457@2|Bacteria,COG0515@2|Bacteria,3Y2YM@57723|Acidobacteria,2JKAC@204432|Acidobacteriia	204432|Acidobacteriia	K	serine threonine protein kinase	-	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	Pkinase,TPR_17
HKD1_k127_944224_3	1121918.ARWE01000001_gene385	1.035e-183	584.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,42MFC@68525|delta/epsilon subdivisions,2WTRK@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Aminotransferase class-III	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD1_k127_944224_5	1410620.SHLA_40c000030	5.085e-57	218.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,4B72Y@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF_2,GGDEF,PAS,PAS_4,PAS_9
HKD1_k127_944224_6	886293.Sinac_0115	8.543e-49	175.0	COG0640@1|root,COG0640@2|Bacteria,2J0DP@203682|Planctomycetes	203682|Planctomycetes	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_944224_7	292.DM42_1134	1.528e-47	175.0	COG3832@1|root,COG3832@2|Bacteria,1RDXJ@1224|Proteobacteria,2WFS3@28216|Betaproteobacteria,1KI5A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD1_k127_944224_8	404589.Anae109_0171	1.952e-39	165.0	COG1293@1|root,COG1293@2|Bacteria,1P028@1224|Proteobacteria,42MKF@68525|delta/epsilon subdivisions,2X6XB@28221|Deltaproteobacteria,2Z3DG@29|Myxococcales	28221|Deltaproteobacteria	K	Domain of unknown function (DUF814)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_944224_11	73044.JNXP01000018_gene1525	4.128e-09	68.0	COG1714@1|root,COG1714@2|Bacteria,2GS9U@201174|Actinobacteria	201174|Actinobacteria	S	RDD family	-	-	-	-	-	-	-	-	-	-	-	-	RDD
HKD1_k127_944224_10	479434.Sthe_2932	2.057e-23	105.0	COG4911@1|root,COG4911@2|Bacteria,2G7A8@200795|Chloroflexi,27YIV@189775|Thermomicrobia	189775|Thermomicrobia	S	Uncharacterized conserved protein (DUF2203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2203
HKD1_k127_963805_1	1267535.KB906767_gene5299	3.075e-209	657.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,3Y652@57723|Acidobacteria	57723|Acidobacteria	G	alpha beta	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_963805_0	452637.Oter_2278	0.0	1433.0	COG1073@1|root,COG3250@1|root,COG1073@2|Bacteria,COG3250@2|Bacteria,46Z55@74201|Verrucomicrobia,3K7F1@414999|Opitutae	414999|Opitutae	G	alpha-L-rhamnosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_106
HKD1_k127_963805_4	99598.Cal7507_5896	5.498e-96	320.0	COG1134@1|root,COG1134@2|Bacteria,1G28R@1117|Cyanobacteria,1HMN9@1161|Nostocales	1117|Cyanobacteria	GM	ABC-type polysaccharide polyol phosphate transport system ATPase component	-	-	-	ko:K09691	ko02010,map02010	M00250	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.103	-	-	ABC_tran,Wzt_C
HKD1_k127_963805_6	525904.Tter_2803	1.399e-72	258.0	COG1682@1|root,COG1682@2|Bacteria,2NQ2H@2323|unclassified Bacteria	2|Bacteria	U	ABC-2 type transporter	-	-	-	ko:K01992,ko:K09690	ko02010,map02010	M00250,M00254	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.103	-	-	ABC2_membrane
HKD1_k127_963805_2	224911.27351908	2.536e-139	458.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2V82Q@28211|Alphaproteobacteria,3JZF5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Glycosyl transferase 4-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_4_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_963805_9	861299.J421_3495	8.46e-42	162.0	COG0110@1|root,COG0110@2|Bacteria	2|Bacteria	S	O-acyltransferase activity	-	-	2.3.1.201	ko:K13018	ko00520,map00520	-	R10100	RC00004,RC00166	ko00000,ko00001,ko01000,ko01005	-	-	-	Hexapep,Hexapep_2
HKD1_k127_963805_3	316274.Haur_4322	4.177e-128	421.0	COG0399@1|root,COG0399@2|Bacteria,2G5QG@200795|Chloroflexi	200795|Chloroflexi	E	aromatic amino acid beta-eliminating lyase threonine aldolase	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_963805_8	1121472.AQWN01000008_gene2021	5.341e-48	190.0	COG0438@1|root,COG0438@2|Bacteria,1TQ1S@1239|Firmicutes,24GPH@186801|Clostridia,260YH@186807|Peptococcaceae	186801|Clostridia	M	PFAM Glycosyl transferase, group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4
HKD1_k127_963805_13	596151.DesfrDRAFT_2898	2.513e-07	63.0	COG2755@1|root,COG2755@2|Bacteria,1NHW6@1224|Proteobacteria,42XAM@68525|delta/epsilon subdivisions,2WSXZ@28221|Deltaproteobacteria,2MDU0@213115|Desulfovibrionales	28221|Deltaproteobacteria	E	GDSL-like Lipase/Acylhydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_963805_5	237368.SCABRO_03695	2.061e-76	271.0	COG0303@1|root,COG0303@2|Bacteria,2IXJ1@203682|Planctomycetes	203682|Planctomycetes	H	Molybdenum cofactor synthesis domain protein	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD1_k127_963805_11	478741.JAFS01000002_gene840	7.595e-33	138.0	COG2227@1|root,COG2227@2|Bacteria,46WME@74201|Verrucomicrobia,37G6N@326457|unclassified Verrucomicrobia	74201|Verrucomicrobia	H	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD1_k127_963805_7	66869.JNXG01000008_gene970	7.174e-51	184.0	COG0315@1|root,COG0315@2|Bacteria,2IHR6@201174|Actinobacteria,41A8A@629295|Streptomyces griseus group	201174|Actinobacteria	H	MoaC family	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD1_k127_963805_10	1303518.CCALI_02289	1.83e-34	143.0	COG1994@1|root,COG1994@2|Bacteria	2|Bacteria	S	metallopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50B
HKD1_k127_963805_12	1122244.AUGF01000046_gene1923	7.313e-11	73.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,3NIKG@468|Moraxellaceae	1236|Gammaproteobacteria	O	Belongs to the peptidase S1C family	mucD	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005575,GO:0005623,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0016787,GO:0017171,GO:0019538,GO:0030288,GO:0030313,GO:0031975,GO:0042597,GO:0043170,GO:0044238,GO:0044464,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
## 4964 queries scanned
## Total time (seconds): 384.6904454231262
## Rate: 12.90 q/s