## Tue Feb 17 06:58:37 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/HKD1_bin.81.fa -m mmseqs --output HKD1_bin.81 --output_dir /data/result/bins/wyx/eggqs50+/HKD1_bin.81 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_1070101_1	1131266.ARWQ01000002_gene654	1.509e-159	508.0	COG1793@1|root,arCOG01347@2157|Archaea,41SCK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD1_k127_1070101_3	1229909.NSED_06110	9.526e-88	294.0	COG1392@1|root,arCOG02640@2157|Archaea,41SGI@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD1_k127_1070101_4	1131266.ARWQ01000002_gene656	2.975e-83	279.0	COG1676@1|root,arCOG01701@2157|Archaea,41SHW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	tRNA intron endonuclease, N-terminal domain	-	-	4.6.1.16	ko:K01170	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_int_endo,tRNA_int_endo_N
HKD1_k127_1070101_5	1131266.ARWQ01000002_gene657	8.634e-36	140.0	arCOG08726@1|root,arCOG08726@2157|Archaea,41STN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1070101_7	1229909.NSED_06125	1.446e-15	78.0	arCOG08727@1|root,arCOG08727@2157|Archaea,41T57@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1070101_0	1229909.NSED_06130	1.609e-237	748.0	COG1028@1|root,arCOG01259@2157|Archaea,41S7V@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_1070101_6	1459636.NTE_01523	8.669e-29	121.0	arCOG10570@1|root,arCOG10570@2157|Archaea,41T75@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1070101_2	1131266.ARWQ01000002_gene660	1.11e-99	331.0	COG0730@1|root,arCOG02050@2157|Archaea,41SKY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD1_k127_1073124_5	436308.Nmar_0294	2.353e-10	61.0	COG2520@1|root,arCOG00033@2157|Archaea,41S7P@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Met-10+ like-protein	-	-	2.1.1.228	ko:K15429	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	Met_10
HKD1_k127_1073124_3	1131266.ARWQ01000015_gene748	3.491e-26	108.0	COG5625@1|root,arCOG04189@2157|Archaea,41T7F@651137|Thaumarchaeota	651137|Thaumarchaeota	K	HTH DNA binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1073124_2	436308.Nmar_0292	1.451e-49	177.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_1073124_4	1229909.NSED_01410	9.891e-23	98.0	COG0456@1|root,arCOG00833@2157|Archaea,41SIY@651137|Thaumarchaeota	651137|Thaumarchaeota	K	FR47-like protein	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_1073124_0	1131266.ARWQ01000015_gene750	6.319e-111	369.0	COG0750@1|root,arCOG00609@2157|Archaea,41S8V@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD1_k127_1073124_1	1131266.ARWQ01000015_gene751	3.098e-101	336.0	COG3875@1|root,arCOG02046@2157|Archaea,41SK4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF2088)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1135219_0	436308.Nmar_1741	4.4e-33	138.0	arCOG08768@1|root,arCOG08768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1158165_0	436308.Nmar_1563	2.48e-154	492.0	COG1736@1|root,arCOG04112@2157|Archaea,41SE0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Diphthamide biosynthesis	-	-	2.5.1.108	ko:K07561	-	-	R10455	RC00021,RC03180	ko00000,ko01000,ko03012	-	-	-	Diphthamide_syn
HKD1_k127_1158165_2	1459636.NTE_01195	5.171e-18	85.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01195|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1158165_1	1229909.NSED_00695	3.461e-123	402.0	COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
HKD1_k127_1171462_1	1229909.NSED_00180	1.296e-132	425.0	COG0443@1|root,arCOG03060@2157|Archaea,41SCM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_1171462_3	1229909.NSED_00175	1.512e-47	176.0	COG0576@1|root,arCOG04772@2157|Archaea,41SSU@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	-	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_1171462_0	1229909.NSED_00170	1.609e-164	525.0	COG0677@1|root,arCOG00252@2157|Archaea,41S8F@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1171462_2	1131266.ARWQ01000001_gene1262	1.526e-88	299.0	COG1817@1|root,arCOG01395@2157|Archaea,41S8D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF354)	-	-	-	ko:K09726	-	-	-	-	ko00000	-	-	-	DUF354
HKD1_k127_1174575_6	1131266.ARWQ01000001_gene1225	1.155e-05	48.0	COG0118@1|root,arCOG00089@2157|Archaea,41SY2@651137|Thaumarchaeota	651137|Thaumarchaeota	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_1174575_5	436308.Nmar_1555	1.15e-81	276.0	COG0131@1|root,arCOG04398@2157|Archaea,41SGY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	imidazoleglycerol-phosphate dehydratase	hisB	-	4.2.1.19	ko:K01693	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03457	RC00932	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPD
HKD1_k127_1174575_4	1229909.NSED_00725	2.616e-99	334.0	COG0546@1|root,arCOG04692@2157|Archaea,41SJ6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2,Hydrolase
HKD1_k127_1174575_2	436308.Nmar_1557	6.06e-146	470.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1174575_1	1229909.NSED_00715	2.543e-151	489.0	COG0141@1|root,arCOG04352@2157|Archaea,41S6J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_1174575_0	1131266.ARWQ01000001_gene1230	2.056e-164	521.0	COG0040@1|root,arCOG02208@2157|Archaea,41SCJ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ATP phosphoribosyltransferase	-	-	2.4.2.17	ko:K00765	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG,HisG_C
HKD1_k127_1174575_3	436308.Nmar_1560	7.618e-138	444.0	COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
HKD1_k127_1193048_3	1229909.NSED_09155	2.287e-44	165.0	COG1701@1|root,arCOG04262@2157|Archaea,41SXP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pfam:DUF137	-	-	6.3.2.36	ko:K09722	ko00410,ko00770,ko01100,map00410,map00770,map01100	-	R09379	RC00096,RC00141	ko00000,ko00001,ko01000	-	-	-	PPS_PS
HKD1_k127_1193048_2	1459636.NTE_02601	3.568e-101	336.0	COG0413@1|root,arCOG00584@2157|Archaea,41SZX@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD1_k127_1193048_0	436308.Nmar_1721	1.39e-182	578.0	COG0452@1|root,arCOG01704@2157|Archaea,41SYG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	-	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_1193048_1	436308.Nmar_1724	7.141e-124	402.0	COG0006@1|root,arCOG01000@2157|Archaea,41T14@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the peptidase M24B family	-	-	3.4.11.9,3.4.13.9	ko:K01262,ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_1206580_3	1131266.ARWQ01000001_gene1183	4.673e-84	284.0	COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	nnrE	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
HKD1_k127_1206580_4	436308.Nmar_0318	4.134e-34	132.0	COG1644@1|root,arCOG04244@2157|Archaea,41SPN@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoN	-	2.7.7.6	ko:K03058	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_N
HKD1_k127_1206580_0	1229909.NSED_01530	1.699e-193	610.0	COG0148@1|root,arCOG01169@2157|Archaea,41SE9@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_1206580_1	1229909.NSED_01525	2.371e-89	299.0	COG0052@1|root,arCOG04245@2157|Archaea,41SG7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS2 family	rps2	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_1206580_2	1131266.ARWQ01000010_gene28	1.225e-87	295.0	COG1355@1|root,arCOG01728@2157|Archaea,41S9D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the MEMO1 family	-	-	-	ko:K06990	-	-	-	-	ko00000,ko04812	-	-	-	Memo
HKD1_k127_1224587_3	1131266.ARWQ01000001_gene1271	6.18e-07	51.0	COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
HKD1_k127_1224587_2	52644.XP_010562524.1	1.245e-12	73.0	COG0484@1|root,KOG0714@2759|Eukaryota,38BTN@33154|Opisthokonta,3BCDV@33208|Metazoa,3CTA3@33213|Bilateria,4846N@7711|Chordata,493F9@7742|Vertebrata,4GJTJ@8782|Aves	33208|Metazoa	O	homolog subfamily B member	DNAJB5	GO:0000122,GO:0002682,GO:0002684,GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005737,GO:0005829,GO:0006355,GO:0006357,GO:0006457,GO:0006950,GO:0006986,GO:0008134,GO:0008150,GO:0008593,GO:0009266,GO:0009408,GO:0009628,GO:0009889,GO:0009890,GO:0009892,GO:0009966,GO:0009968,GO:0009987,GO:0010033,GO:0010468,GO:0010556,GO:0010558,GO:0010605,GO:0010629,GO:0010646,GO:0010648,GO:0019219,GO:0019222,GO:0023051,GO:0023057,GO:0031323,GO:0031324,GO:0031326,GO:0031327,GO:0031647,GO:0035966,GO:0042221,GO:0042689,GO:0042691,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0045595,GO:0045597,GO:0045610,GO:0045612,GO:0045746,GO:0045892,GO:0045934,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048583,GO:0048585,GO:0050789,GO:0050793,GO:0050794,GO:0050821,GO:0050896,GO:0051082,GO:0051087,GO:0051094,GO:0051171,GO:0051172,GO:0051239,GO:0051252,GO:0051253,GO:0060255,GO:0065007,GO:0065008,GO:0080090,GO:1902679,GO:1903506,GO:1903507,GO:2000112,GO:2000113,GO:2001141	-	ko:K09507,ko:K09510,ko:K09511	ko04141,ko05164,map04141,map05164	-	-	-	ko00000,ko00001,ko03110	-	-	-	DnaJ,DnaJ_C
HKD1_k127_1224587_0	1131266.ARWQ01000001_gene1270	4.369e-87	296.0	COG0702@1|root,arCOG03015@2157|Archaea,41T19@651137|Thaumarchaeota	651137|Thaumarchaeota	M	NAD(P)H-binding	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	NAD_binding_10
HKD1_k127_1224587_1	1459636.NTE_01726	7.016e-25	105.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_1227674_1	436308.Nmar_0100	2.811e-164	526.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD1_k127_1227674_0	436308.Nmar_0101	0.0	1289.0	COG0464@1|root,arCOG01308@2157|Archaea,41SB6@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cell division protein 48 (CDC48), domain 2	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD1_k127_1227674_2	1229909.NSED_00220	1.56e-28	115.0	COG0090@1|root,arCOG04067@2157|Archaea,41SCT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rpl2	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD1_k127_1239190_1	1229909.NSED_05185	7.583e-109	355.0	COG1899@1|root,arCOG04142@2157|Archaea,41SWS@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Deoxyhypusine synthase	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD1_k127_1239190_0	436308.Nmar_1177	3.73e-117	386.0	COG1164@1|root,arCOG04758@2157|Archaea,41S7J@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M3	-	-	-	ko:K08602	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M3,Peptidase_M3_N
HKD1_k127_1307632_2	1229909.NSED_07830	2.031e-19	91.0	COG1818@1|root,arCOG00084@2157|Archaea,41SNW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	THUMP domain	-	-	-	ko:K06963	-	-	-	-	ko00000,ko03016	-	-	-	THUMP
HKD1_k127_1307632_0	436308.Nmar_1429	1.955e-71	250.0	COG1617@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG02197@2157|Archaea,41SSW@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Kinase binding protein CGI-121	-	-	-	-	-	-	-	-	-	-	-	-	CGI-121,ThiS
HKD1_k127_1307632_3	436308.Nmar_1430	2.806e-18	87.0	COG1383@1|root,arCOG01885@2157|Archaea,41SUH@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02962	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17e
HKD1_k127_1307632_1	1229909.NSED_07845	4.217e-23	99.0	COG0084@1|root,arCOG00891@2157|Archaea,41SGP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	TatD related DNase	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_1312480_1	1229909.NSED_09905	2.868e-83	283.0	COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_1312480_4	1229909.NSED_01055	1.925e-36	143.0	COG1656@1|root,arCOG04290@2157|Archaea,41T65@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Mut7-C RNAse domain	-	-	-	ko:K09122	-	-	-	-	ko00000	-	-	-	Mut7-C
HKD1_k127_1312480_2	1131266.ARWQ01000010_gene27	4.066e-74	254.0	COG2078@1|root,arCOG01336@2157|Archaea,41SMG@651137|Thaumarchaeota	651137|Thaumarchaeota	S	AMMECR1	-	-	-	ko:K09141	-	-	-	-	ko00000	-	-	-	AMMECR1
HKD1_k127_1312480_3	1229909.NSED_09900	2.833e-39	150.0	COG1786@1|root,arCOG04279@2157|Archaea,41SPA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Protein of unknown function DUF126	-	-	-	ko:K09128	-	-	-	-	ko00000	-	-	-	DUF126
HKD1_k127_1312480_0	436308.Nmar_0053	1.221e-163	522.0	COG1679@1|root,arCOG04278@2157|Archaea,41SBC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF521)	-	-	-	ko:K09123	-	-	-	-	ko00000	-	-	-	DUF521
HKD1_k127_1312480_5	1229909.NSED_09885	9.833e-30	120.0	COG0177@1|root,arCOG00459@2157|Archaea,41SFM@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_1318222_0	1131266.ARWQ01000008_gene342	1.611e-265	822.0	COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18604	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_1318222_1	436308.Nmar_0273	1.663e-97	322.0	COG0439@1|root,arCOG01590@2157|Archaea,41SXC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Carbamoyl-phosphate synthase L chain	-	-	6.4.1.2,6.4.1.3	ko:K18603	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD1_k127_1326481_1	1229909.NSED_04635	1.603e-68	236.0	COG2141@1|root,arCOG02410@2157|Archaea,41SC0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD1_k127_1326481_0	1131266.ARWQ01000002_gene540	5.846e-136	441.0	COG0183@1|root,arCOG01278@2157|Archaea,41SB7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_1326481_2	1131266.ARWQ01000002_gene541	8.355e-29	119.0	COG1545@1|root,arCOG01285@2157|Archaea	2157|Archaea	I	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD1_k127_1326481_3	1459636.NTE_01553	8.746e-12	65.0	arCOG12283@1|root,arCOG12283@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1342234_3	1229909.NSED_08280	5.097e-07	53.0	arCOG08673@1|root,arCOG08673@2157|Archaea,41SVK@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1342234_0	1459636.NTE_02867	1.312e-32	129.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2226,P-II
HKD1_k127_1342234_1	1229909.NSED_09060	1.328e-25	116.0	COG1468@1|root,arCOG00790@2157|Archaea,41T4T@651137|Thaumarchaeota	651137|Thaumarchaeota	V	CRISPR-associated protein Cas4	-	-	3.1.12.1	ko:K07464	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	-
HKD1_k127_1342234_2	1459636.NTE_01251	9.743e-10	61.0	arCOG08730@1|root,arCOG08730@2157|Archaea,41SNH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1354513_1	1120998.AUFC01000019_gene275	8.452e-95	312.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,3WCCW@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_1354513_0	1120998.AUFC01000019_gene276	2.493e-177	559.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,3WDCS@538999|Clostridiales incertae sedis	186801|Clostridia	E	Glutamine synthetase, catalytic domain	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD1_k127_1361408_1	1131266.ARWQ01000001_gene1361	2.098e-259	805.0	COG0174@1|root,arCOG01909@2157|Archaea,41SD6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM glutamine synthetase, type I	-	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_1361408_3	436308.Nmar_1791	3.568e-19	92.0	arCOG08808@1|root,arCOG08808@2157|Archaea,41T95@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1361408_0	436308.Nmar_1792	2.924e-280	870.0	COG0459@1|root,arCOG01257@2157|Archaea,41SDG@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PFAM TCP-1 cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_1361408_2	436308.Nmar_1793	3.39e-108	355.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD1_k127_1372052_0	436308.Nmar_0592	3.712e-200	630.0	COG1060@1|root,arCOG00656@2157|Archaea,41SDT@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.77	ko:K11781	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_1372052_1	436308.Nmar_0593	1.905e-167	533.0	COG1060@1|root,arCOG00657@2157|Archaea,41S95@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Radical SAM	-	-	2.5.1.77	ko:K11780	ko00680,ko01120,map00680,map01120	M00378	R09396	RC01381,RC03002,RC03007	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_1372052_2	436308.Nmar_0594	2.259e-22	98.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Trypsin-like serine protease with C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_1387136_0	436308.Nmar_0652	6.072e-126	408.0	COG4608@1|root,arCOG00184@2157|Archaea,41S9E@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02032	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_1387136_1	436308.Nmar_0651	7.75e-98	323.0	COG1196@1|root,arCOG00371@2157|Archaea,41SDS@651137|Thaumarchaeota	651137|Thaumarchaeota	D	SMC proteins Flexible Hinge Domain	-	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_1398526_4	1229909.NSED_09695	8.88e-13	70.0	arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1398526_5	1459636.NTE_02269	4.044e-06	51.0	COG0431@1|root,arCOG04624@2157|Archaea	2157|Archaea	S	NAD(P)H-dependent FMN reductase	ssuE1	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD1_k127_1398526_0	1459636.NTE_03329	1.372e-54	194.0	COG0431@1|root,arCOG04624@2157|Archaea	2157|Archaea	S	NAD(P)H-dependent FMN reductase	ssuE1	-	1.5.1.38	ko:K00299	ko00740,ko00920,ko01100,map00740,map00920,map01100	-	R05706,R07210,R10206	RC00126,RC01779,RC02556	ko00000,ko00001,ko01000	-	-	-	FMN_red
HKD1_k127_1398526_3	1229909.NSED_03455	2.652e-26	113.0	COG0589@1|root,arCOG02053@2157|Archaea,41T8M@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1398526_2	1229909.NSED_08005	6.786e-31	126.0	COG0589@1|root,arCOG02053@2157|Archaea,41TB2@651137|Thaumarchaeota	651137|Thaumarchaeota	T	COG0589 Universal stress protein UspA and related nucleotide-binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1398526_1	1459636.NTE_00321	3.085e-33	131.0	arCOG11305@1|root,arCOG11305@2157|Archaea,41T7G@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1468242_0	1131266.ARWQ01000002_gene674	1.999e-216	676.0	COG0028@1|root,arCOG01998@2157|Archaea,41S63@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM acetolactate synthase, large subunit, biosynthetic type	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_1468242_2	1229909.NSED_00195	4.42e-10	61.0	arCOG10416@1|root,arCOG10416@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1468242_1	1459636.NTE_02455	1.367e-23	100.0	COG1143@1|root,COG3260@1|root,arCOG01543@2157|Archaea,arCOG01553@2157|Archaea	2157|Archaea	C	PFAM NADH ubiquinone oxidoreductase 20 kDa subunit	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_q6
HKD1_k127_1490893_1	1459636.NTE_02785	2.474e-107	355.0	COG0477@1|root,arCOG00132@2157|Archaea	2157|Archaea	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_1490893_2	1131266.ARWQ01000006_gene260	1.736e-92	315.0	COG2084@1|root,arCOG00247@2157|Archaea,41SI2@651137|Thaumarchaeota	651137|Thaumarchaeota	I	NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase	-	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD1_k127_1490893_0	1131266.ARWQ01000002_gene452	6.024e-180	567.0	COG0059@1|root,arCOG04465@2157|Archaea,41S65@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	-	IlvC,IlvN
HKD1_k127_1490893_3	1459636.NTE_01111	5.539e-28	114.0	COG2185@1|root,arCOG01710@2157|Archaea,41SJN@651137|Thaumarchaeota	651137|Thaumarchaeota	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD1_k127_1495380_3	1229909.NSED_04690	7.252e-17	85.0	arCOG10553@1|root,arCOG10553@2157|Archaea,41T8J@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1495380_1	436308.Nmar_0852	2.312e-36	142.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T7E@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1495380_0	1229909.NSED_04700	2.518e-46	170.0	COG0346@1|root,arCOG02708@2157|Archaea,41SU3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Glyoxalase-like domain	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase,Glyoxalase_2
HKD1_k127_1495380_2	1229909.NSED_04710	1.594e-28	115.0	arCOG08032@1|root,arCOG08032@2157|Archaea,41T69@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1557863_1	1229909.NSED_02460	3.502e-79	268.0	COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD1_k127_1557863_0	436308.Nmar_0490	4.341e-167	531.0	COG0001@1|root,arCOG00918@2157|Archaea,41SDE@651137|Thaumarchaeota	651137|Thaumarchaeota	H	PFAM aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1571541_3	436308.Nmar_1410	3.312e-23	104.0	COG1718@1|root,arCOG01180@2157|Archaea,41T2X@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Serine threonine protein kinase involved in cell cycle control	-	-	2.7.11.1	ko:K07178	ko03008,map03008	-	-	-	ko00000,ko00001,ko01000,ko01001,ko03009	-	-	-	RIO1
HKD1_k127_1571541_1	1131266.ARWQ01000005_gene783	3.045e-41	154.0	COG0361@1|root,arCOG01179@2157|Archaea,41SRK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits	-	-	-	ko:K03236	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	eIF-1a
HKD1_k127_1571541_2	1229909.NSED_07750	4.636e-27	112.0	COG2412@1|root,arCOG04051@2157|Archaea,41SS6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF424)	-	-	-	ko:K09148	-	-	-	-	ko00000	-	-	-	DUF424
HKD1_k127_1571541_0	436308.Nmar_1412	7.65e-60	209.0	COG1601@1|root,arCOG01640@2157|Archaea,41STZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Translation initiation factor	-	-	-	ko:K03238	ko03013,map03013	-	-	-	ko00000,ko00001,ko01009,ko03012	-	-	-	eIF-5_eIF-2B
HKD1_k127_1571541_4	436308.Nmar_1413	3.649e-18	84.0	arCOG07442@1|root,arCOG07442@2157|Archaea,41SWG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1626284_1	1229909.NSED_01885	5.29e-56	198.0	COG1717@1|root,arCOG00781@2157|Archaea,41SP5@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02912	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L32e
HKD1_k127_1626284_0	1131266.ARWQ01000028_gene1022	1.466e-257	803.0	COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD1_k127_1626284_2	1131266.ARWQ01000028_gene1021	1.25e-20	96.0	COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the peptidase S8 family	-	-	-	ko:K14647	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PA,Peptidase_S8
HKD1_k127_163613_3	436308.Nmar_1182	9.392e-18	83.0	COG0513@1|root,arCOG00558@2157|Archaea,41SM1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_163613_1	436308.Nmar_0209	5.308e-80	273.0	arCOG08023@1|root,arCOG08023@2157|Archaea,41SKK@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Zinc finger domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HKD1_k127_163613_2	436308.Nmar_0208	1.515e-69	242.0	COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_163613_0	1131266.ARWQ01000008_gene326	2.146e-91	302.0	COG2368@1|root,arCOG02143@2157|Archaea,41SA0@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Vinylacetyl-CoA Delta-isomerase	-	-	4.2.1.120,5.3.3.3	ko:K14534	ko00650,ko00720,ko01100,ko01120,ko01200,map00650,map00720,map01100,map01120,map01200	M00374,M00375	R03031,R10782	RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
HKD1_k127_1646709_4	436308.Nmar_1585	1.088e-52	189.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD1_k127_1646709_0	1229909.NSED_00585	3.409e-111	365.0	COG1492@1|root,arCOG00105@2157|Archaea,41SG6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	-	CbiA
HKD1_k127_1646709_1	436308.Nmar_1583	1.243e-110	367.0	COG1270@1|root,arCOG04274@2157|Archaea,41S6I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group	cobD	-	6.3.1.10	ko:K02227	ko00860,ko01100,map00860,map01100	M00122	R06529,R07302	RC00090,RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	CobD_Cbib
HKD1_k127_1646709_2	1459636.NTE_03117	1.323e-63	226.0	COG0368@1|root,arCOG04338@2157|Archaea,41SI6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD1_k127_1646709_3	1131266.ARWQ01000009_gene959	6.978e-62	218.0	COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota	651137|Thaumarchaeota	M	MobA-like NTP transferase domain	-	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_1646709_6	768679.TTX_0576	2.173e-11	66.0	COG2051@1|root,arCOG04108@2157|Archaea,2XR0Y@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
HKD1_k127_1646709_5	1229909.NSED_00610	7.219e-20	89.0	COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
HKD1_k127_1699197_3	1131266.ARWQ01000008_gene305	0.0001344	46.0	COG1976@1|root,arCOG04176@2157|Archaea,41SIP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex	eif6	-	-	ko:K03264	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009,ko03012	-	-	-	eIF-6
HKD1_k127_1699197_2	1459636.NTE_00377	6.366e-54	193.0	COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM 4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_1699197_1	1229909.NSED_02855	3.042e-89	296.0	COG1146@1|root,arCOG04548@2157|Archaea,41SI0@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM 4Fe-4S dicluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_1699197_0	1131266.ARWQ01000008_gene300	3.676e-137	442.0	COG0470@1|root,arCOG00469@2157|Archaea,41SFJ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Replication factor C	-	-	-	ko:K04801	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	DNA_pol3_delta2,Rep_fac_C,RuvB_N
HKD1_k127_1709464_0	1229909.NSED_00970	2.389e-171	544.0	COG0532@1|root,arCOG01560@2157|Archaea,41SBY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2	infB	-	-	ko:K03243	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D4,IF-2
HKD1_k127_1709464_1	436308.Nmar_0230	1.205e-39	151.0	COG0526@1|root,arCOG01972@2157|Archaea,41T6S@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_1709464_2	436308.Nmar_0232	9.078e-09	57.0	COG1371@1|root,arCOG04055@2157|Archaea,41SU0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD1_k127_174842_1	1031288.AXAA01000006_gene1141	1.283e-98	326.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,36DQ1@31979|Clostridiaceae	186801|Clostridia	K	domain protein	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD1_k127_174842_0	941824.TCEL_01264	5.044e-158	503.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,36DUM@31979|Clostridiaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_1760349_0	436308.Nmar_0440	7.571e-96	316.0	COG0061@1|root,arCOG01348@2157|Archaea,41SHP@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD1_k127_1760349_2	1229909.NSED_02275	1.946e-46	172.0	COG1439@1|root,arCOG00721@2157|Archaea,41SPQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PIN domain of ribonuclease	-	-	-	ko:K07060	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	PIN_6
HKD1_k127_1760349_1	1229909.NSED_02270	4.108e-60	210.0	COG1948@1|root,arCOG04206@2157|Archaea,41SIH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	ERCC4 domain	-	-	-	ko:K10848	ko03420,ko03460,map03420,map03460	-	-	-	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	ERCC4,HHH_5
HKD1_k127_178950_3	861299.J421_3006	1.501e-32	130.0	2E5IJ@1|root,3309Y@2|Bacteria,1ZTU3@142182|Gemmatimonadetes	142182|Gemmatimonadetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_178950_0	436308.Nmar_0516	1.776e-130	420.0	COG0396@1|root,arCOG04236@2157|Archaea,41SE1@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly ATPase SufC	-	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD1_k127_178950_2	1459636.NTE_03340	2.542e-37	142.0	COG3432@1|root,arCOG01055@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
HKD1_k127_178950_1	1459636.NTE_00929	3.142e-93	312.0	COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
HKD1_k127_182239_1	273063.STK_18060	1.127e-05	55.0	COG0517@1|root,arCOG00606@2157|Archaea,2XSB6@28889|Crenarchaeota	28889|Crenarchaeota	S	PFAM CBS domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_182239_0	382464.ABSI01000010_gene3727	2.326e-59	214.0	COG3243@1|root,COG3243@2|Bacteria	2|Bacteria	I	poly(R)-hydroxyalkanoic acid synthase	phaC	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0008152,GO:0009058,GO:0016234,GO:0042618,GO:0042619,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0044424,GO:0044444,GO:0044464,GO:0070088,GO:0071704,GO:1901440,GO:1901441,GO:1901576	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	iJN678.phbC	Abhydrolase_1
HKD1_k127_1855232_0	1229909.NSED_06830	1.394e-21	97.0	COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota	651137|Thaumarchaeota	V	antibiotic catabolic process	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HKD1_k127_200857_0	931276.Cspa_c31080	1.685e-21	98.0	COG0457@1|root,COG0457@2|Bacteria,1UYZH@1239|Firmicutes,24BU9@186801|Clostridia,36F2E@31979|Clostridiaceae	186801|Clostridia	S	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_16,TPR_2,TPR_8
HKD1_k127_200857_1	1229909.NSED_00635	2.744e-18	89.0	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_201821_0	1131266.ARWQ01000004_gene1467	1.797e-137	441.0	COG1042@1|root,arCOG01338@2157|Archaea,arCOG01340@2157|Archaea,41S7I@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA ligase like flavodoxin domain	-	-	-	ko:K18594	ko00720,ko01120,map00720,map01120	-	R03157	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	ATP-grasp_5,CoA_binding_2,Succ_CoA_lig
HKD1_k127_203000_1	1131266.ARWQ01000006_gene216	4.978e-13	69.0	COG1243@1|root,arCOG01361@2157|Archaea,41S9N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Histone acetyltransferase	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
HKD1_k127_203000_0	1229909.NSED_03040	1.143e-262	817.0	COG1384@1|root,arCOG00485@2157|Archaea,41SB4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
HKD1_k127_203000_2	1131266.ARWQ01000006_gene214	5.304e-10	61.0	arCOG10985@1|root,arCOG10985@2157|Archaea,41T8V@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2225901_1	436308.Nmar_1628	1.281e-187	593.0	COG0640@1|root,COG1328@1|root,arCOG00734@2157|Archaea,arCOG04889@2157|Archaea,41SBG@651137|Thaumarchaeota	651137|Thaumarchaeota	FK	Anaerobic ribonucleoside-triphosphate reductase	-	-	1.1.98.6	ko:K21636	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R11633,R11634,R11635,R11636	RC00613	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-cone,HTH_20,NRDD
HKD1_k127_2225901_8	1229909.NSED_08880	2.931e-20	90.0	arCOG08792@1|root,arCOG08792@2157|Archaea,41SUG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2225901_6	1131266.ARWQ01000009_gene924	2.601e-41	156.0	COG1545@1|root,arCOG01285@2157|Archaea,41SQK@651137|Thaumarchaeota	651137|Thaumarchaeota	V	nucleic-acid-binding protein containing a Zn-ribbon	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD1_k127_2225901_0	1229909.NSED_08890	1.656e-217	678.0	COG0183@1|root,arCOG01278@2157|Archaea,41SCI@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thiolase, N-terminal domain	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_2225901_5	1131266.ARWQ01000009_gene926	2.806e-53	192.0	arCOG10412@1|root,arCOG10412@2157|Archaea,41SS9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2225901_2	436308.Nmar_1633	2.667e-124	402.0	COG0388@1|root,arCOG00062@2157|Archaea,41SF8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Carbon-nitrogen hydrolase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD1_k127_2225901_7	1229909.NSED_08905	9.263e-26	108.0	arCOG02240@1|root,arCOG02240@2157|Archaea,41SSM@651137|Thaumarchaeota	651137|Thaumarchaeota	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD1_k127_2225901_3	1131266.ARWQ01000009_gene929	6.632e-91	305.0	COG0705@1|root,arCOG01768@2157|Archaea,41SKD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Rhomboid family	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD1_k127_2225901_4	1459636.NTE_00334	1.822e-89	313.0	arCOG08812@1|root,arCOG08812@2157|Archaea,41SXB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2229775_0	1459636.NTE_02360	1.109e-108	369.0	COG1955@1|root,arCOG01809@2157|Archaea	2157|Archaea	N	archaeal flagella assembly protein J	flaJ	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
HKD1_k127_2229775_2	436308.Nmar_0251	1.857e-26	113.0	COG0784@1|root,arCOG02391@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_2229775_1	1229909.NSED_05315	1.874e-52	192.0	COG0640@1|root,arCOG03067@2157|Archaea	2157|Archaea	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_22524_1	1459636.NTE_02255	1.48e-29	123.0	COG1238@1|root,arCOG03118@2157|Archaea	2157|Archaea	I	SNARE associated Golgi protein	-	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
HKD1_k127_22524_0	1131266.ARWQ01000002_gene454	2.33e-204	647.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HKD1_k127_2273485_0	1459636.NTE_02854	1.396e-117	386.0	COG0614@1|root,arCOG04233@2157|Archaea,41SXD@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_2273485_3	351160.RRC185	1.333e-51	193.0	COG0639@1|root,arCOG01143@2157|Archaea,2Y4JH@28890|Euryarchaeota,2NB43@224756|Methanomicrobia	224756|Methanomicrobia	T	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_2273485_2	436308.Nmar_0022	3.449e-77	261.0	COG3945@1|root,arCOG01471@2157|Archaea,41SZW@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_2273485_1	1131266.ARWQ01000001_gene1105	1.343e-80	277.0	arCOG01449@1|root,arCOG01449@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K07725	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	-
HKD1_k127_2273485_4	436308.Nmar_0025	6.155e-14	73.0	arCOG08813@1|root,arCOG08813@2157|Archaea,41T88@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2297512_1	1229909.NSED_08220	3.09e-40	151.0	COG1986@1|root,arCOG01223@2157|Archaea,41SKV@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Cytidylyltransferase-like	-	-	2.7.7.3	ko:K02201	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_2297512_0	436308.Nmar_1495	7.776e-43	169.0	arCOG08642@1|root,arCOG08642@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2305180_1	436308.Nmar_1714	9.48e-97	325.0	COG4591@1|root,arCOG02313@2157|Archaea,41TBB@651137|Thaumarchaeota	651137|Thaumarchaeota	M	FtsX-like permease family	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD1_k127_2305180_0	1229909.NSED_09130	7.394e-107	353.0	COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
HKD1_k127_2325934_0	1229909.NSED_02195	9.901e-133	426.0	COG0065@1|root,arCOG01698@2157|Archaea,41SYT@651137|Thaumarchaeota	651137|Thaumarchaeota	E	3-isopropylmalate dehydratase, large subunit	-	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD1_k127_2325934_6	436308.Nmar_0423	1.591e-75	257.0	COG0066@1|root,arCOG02230@2157|Archaea,41T1U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	3-isopropylmalate dehydratase, small subunit	-	-	4.2.1.33,4.2.1.35	ko:K01704	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R10170	RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_2325934_3	436308.Nmar_0424	1.616e-83	283.0	COG1208@1|root,arCOG00663@2157|Archaea	2157|Archaea	M	PFAM Nucleotidyl transferase	-	-	2.6.1.37,2.7.7.13	ko:K00966,ko:K03430	ko00051,ko00440,ko00520,ko01100,ko01110,ko01120,map00051,map00440,map00520,map01100,map01110,map01120	M00114,M00361,M00362	R00885,R04152	RC00002,RC00008,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	NTP_transferase
HKD1_k127_2325934_7	1229909.NSED_02210	6.592e-65	224.0	COG0088@1|root,arCOG04243@2157|Archaea,41SKT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS9 family	-	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_2325934_8	1131266.ARWQ01000030_gene992	4.582e-51	185.0	COG0102@1|root,arCOG04242@2157|Archaea,41SP4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rpl13	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_2325934_9	436308.Nmar_0427	1.2e-39	150.0	COG1727@1|root,arCOG00780@2157|Archaea,41SRE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	-	-	-	ko:K02883	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18
HKD1_k127_2325934_5	436308.Nmar_0428	3.36e-80	272.0	COG0202@1|root,arCOG04241@2157|Archaea,41SK0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-directed RNA polymerase, alpha subunit 40 kD subunit	-	-	2.7.7.6	ko:K03047	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_A_bac,RNA_pol_L
HKD1_k127_2325934_2	436308.Nmar_0430	2.778e-99	328.0	COG1500@1|root,arCOG04187@2157|Archaea,41SC7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Shwachman-Bodian-Diamond syndrome (SBDS) protein	-	-	-	ko:K14574	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	SBDS,SBDS_C
HKD1_k127_2325934_1	1229909.NSED_02240	8.473e-104	341.0	COG1097@1|root,arCOG00678@2157|Archaea,41SHV@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome	rrp4	-	-	ko:K03679	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	KH_1
HKD1_k127_2325934_4	1229909.NSED_02245	7.895e-82	274.0	COG0689@1|root,arCOG01575@2157|Archaea,41S81@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_2336345_3	1459636.NTE_01522	5.882e-37	141.0	COG1960@1|root,arCOG01707@2157|Archaea	2157|Archaea	I	COG1960 Acyl-CoA dehydrogenases	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_2336345_2	1459636.NTE_01522	2.087e-57	203.0	COG1960@1|root,arCOG01707@2157|Archaea	2157|Archaea	I	COG1960 Acyl-CoA dehydrogenases	gcdH	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_2336345_1	436308.Nmar_0507	9.175e-82	276.0	COG1418@1|root,arCOG01860@2157|Archaea,41T2N@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_2336345_4	1131266.ARWQ01000005_gene820	2.438e-36	139.0	arCOG08763@1|root,arCOG08763@2157|Archaea,41SWC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2336345_0	1229909.NSED_02555	1.054e-83	280.0	COG0113@1|root,arCOG04300@2157|Archaea,41SET@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Delta-aminolevulinic acid dehydratase	-	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD1_k127_2353603_1	1131266.ARWQ01000003_gene1579	1.389e-47	175.0	COG1571@1|root,arCOG01115@2157|Archaea,41S9G@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA	tiaS	-	6.3.4.22	ko:K06932	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1743
HKD1_k127_2353603_0	1229909.NSED_00700	1.689e-130	426.0	COG2133@1|root,arCOG02796@2157|Archaea,41S7F@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_2353603_2	1229909.NSED_00705	5.214e-32	126.0	COG1257@1|root,arCOG04260@2157|Archaea,41SAU@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the HMG-CoA reductase family	-	-	1.1.1.88	ko:K00054	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R02081	RC00004,RC00644	ko00000,ko00001,ko01000	-	-	-	HMG-CoA_red
HKD1_k127_2353793_1	1229909.NSED_01645	3.302e-20	98.0	arCOG08033@1|root,arCOG08643@1|root,arCOG08033@2157|Archaea,arCOG08643@2157|Archaea,41T3A@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2353793_0	1229909.NSED_09495	1.037e-214	674.0	COG1509@1|root,arCOG03246@2157|Archaea,41SY6@651137|Thaumarchaeota	651137|Thaumarchaeota	E	TIGRFAM lysine 2,3-aminomutase YodO family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2365731_1	771875.Ferpe_0354	9.02e-131	429.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,2GC4M@200918|Thermotogae	200918|Thermotogae	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD1_k127_2365731_2	1229909.NSED_00655	6.282e-107	354.0	COG0294@1|root,arCOG02817@2157|Archaea,41SGK@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Pterin binding enzyme	-	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD1_k127_2365731_3	1131266.ARWQ01000003_gene1586	4.792e-84	285.0	COG1634@1|root,arCOG04303@2157|Archaea,41SKX@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP)	mptE	-	2.7.6.3	ko:K07142	ko00790,map00790	-	R03503	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	MAF_flag10
HKD1_k127_2365731_4	1131266.ARWQ01000009_gene966	2.971e-41	159.0	arCOG05463@1|root,arCOG05463@2157|Archaea,41SR3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2365731_0	1229909.NSED_00640	5.038e-233	726.0	COG0519@1|root,arCOG00085@2157|Archaea,41SDI@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD1_k127_2379437_2	1459636.NTE_01449	2.538e-12	68.0	COG0494@1|root,COG1853@1|root,arCOG01083@2157|Archaea,arCOG02017@2157|Archaea	2157|Archaea	L	PFAM flavin reductase domain protein, FMN-binding	-	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0008150,GO:0008152,GO:0010181,GO:0016491,GO:0016722,GO:0016723,GO:0032553,GO:0036094,GO:0042802,GO:0042803,GO:0043167,GO:0043168,GO:0046983,GO:0048037,GO:0050662,GO:0055114,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.16.1.10,3.6.1.55	ko:K03574,ko:K18915	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Flavin_Reduct,NUDIX
HKD1_k127_2379437_1	436308.Nmar_0835	6.107e-25	108.0	arCOG08697@1|root,arCOG08697@2157|Archaea,41SUN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2379437_0	1229909.NSED_04595	1.417e-203	638.0	COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_2410089_3	436308.Nmar_0044	1.083e-106	351.0	COG0300@1|root,arCOG01263@2157|Archaea,41SXQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD1_k127_2410089_6	436308.Nmar_0045	8.016e-39	148.0	arCOG10514@1|root,arCOG10514@2157|Archaea,41STR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2410089_7	1131266.ARWQ01000001_gene1322	9.06e-21	93.0	arCOG08817@1|root,arCOG08817@2157|Archaea,41SV5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2410089_0	436308.Nmar_0047	7.261e-174	554.0	COG1819@1|root,arCOG01393@2157|Archaea,41SZK@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Glycosyl transferase family 1	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2410089_4	436308.Nmar_0048	2.852e-99	336.0	COG0301@1|root,arCOG00038@2157|Archaea,41ST5@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2410089_2	1131266.ARWQ01000001_gene1319	3.566e-122	395.0	COG0175@1|root,arCOG00124@2157|Archaea,41S9Q@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Phosphoadenosine phosphosulfate reductase family	-	-	1.8.4.10,1.8.4.8	ko:K00390	ko00920,ko01100,ko01120,map00920,map01100,map01120	M00176	R02021	RC00007,RC02862	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD1_k127_2410089_1	1459636.NTE_02663	2.824e-157	504.0	COG2046@1|root,arCOG04191@2157|Archaea,41SER@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Belongs to the sulfate adenylyltransferase family	sat	-	2.7.7.4	ko:K00958	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-sulfurylase,PUA_2
HKD1_k127_2410089_5	1229909.NSED_09880	3.847e-41	158.0	arCOG08818@1|root,arCOG08818@2157|Archaea,41SVV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2455867_0	1459636.NTE_00052	1.374e-102	339.0	COG0125@1|root,arCOG01891@2157|Archaea	1459636.NTE_00052|-	F	thymidylate kinase	-	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_2455867_1	1459636.NTE_00051	1.519e-28	116.0	COG0125@1|root,arCOG01891@2157|Archaea	2157|Archaea	F	thymidylate kinase	-	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_2481662_1	436308.Nmar_1120	1.002e-102	337.0	COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_2481662_4	1229909.NSED_08555	9.792e-15	82.0	arCOG08793@1|root,arCOG08793@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2481662_0	436308.Nmar_1091	1.487e-153	494.0	COG1378@1|root,arCOG02037@2157|Archaea,41T17@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Sugar-specific transcriptional regulator TrmB	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
HKD1_k127_2481662_2	436308.Nmar_1090	2.898e-27	118.0	COG5491@1|root,arCOG00452@2157|Archaea	2157|Archaea	N	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	Snf7
HKD1_k127_2481662_3	436308.Nmar_1089	6.056e-17	88.0	arCOG08707@1|root,arCOG08707@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2497272_1	436308.Nmar_1432	1.634e-24	104.0	COG2036@1|root,arCOG02144@2157|Archaea,41T91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	transcription factor (CBF NF-Y)	-	-	-	-	-	-	-	-	-	-	-	-	CBFD_NFYB_HMF
HKD1_k127_2497272_0	1229909.NSED_07860	2.051e-294	912.0	arCOG06613@1|root,arCOG06613@2157|Archaea,41T0Z@651137|Thaumarchaeota	651137|Thaumarchaeota	V	AIPR protein	-	-	-	-	-	-	-	-	-	-	-	-	AIPR
HKD1_k127_2497272_2	1131266.ARWQ01000001_gene1074	4.197e-16	79.0	arCOG08678@1|root,arCOG08678@2157|Archaea,41TA6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2497272_3	436308.Nmar_0525	1.803e-10	62.0	COG0727@1|root,arCOG02579@2157|Archaea,41T3E@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_2558887_0	1131266.ARWQ01000001_gene1153	0.0	1150.0	COG0013@1|root,arCOG01255@2157|Archaea,41SBJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_2558887_1	1131266.ARWQ01000001_gene1152	4.435e-65	227.0	arCOG08745@1|root,arCOG08745@2157|Archaea,41SU1@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2558887_2	436308.Nmar_0374	3.545e-33	131.0	COG2058@1|root,arCOG04287@2157|Archaea,41SP0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rpl12	-	-	ko:K02869	ko03010,map03010	M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_60s
HKD1_k127_261682_1	1229909.NSED_00915	1.259e-84	286.0	COG0120@1|root,arCOG01122@2157|Archaea,41SJE@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Ribose 5-phosphate isomerase	-	-	5.3.1.6	ko:K01807	ko00030,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167,M00580	R01056	RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	Rib_5-P_isom_A
HKD1_k127_261682_0	1131266.ARWQ01000008_gene320	2.08e-210	663.0	COG0044@1|root,arCOG00689@2157|Archaea,41S8A@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD1_k127_2628897_4	436308.Nmar_0549	4.725e-22	98.0	COG1685@1|root,arCOG01025@2157|Archaea,41SGZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	GHMP kinases N terminal domain	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_2628897_0	1131266.ARWQ01000017_gene883	1.16e-105	349.0	COG0169@1|root,arCOG01033@2157|Archaea,41S6G@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_2628897_5	1229909.NSED_06430	1.26e-07	56.0	arCOG10576@1|root,arCOG10576@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2628897_1	1229909.NSED_02795	2.123e-81	278.0	COG0169@1|root,arCOG02097@2157|Archaea,41SKU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	-	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
HKD1_k127_2628897_3	1229909.NSED_01175	4.127e-38	144.0	COG1581@1|root,arCOG01753@2157|Archaea,41SQ4@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
HKD1_k127_2628897_2	1459636.NTE_01958	1.925e-57	206.0	COG0863@1|root,arCOG00115@2157|Archaea,41SZP@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA methylase	-	-	2.1.1.113,2.1.1.72	ko:K00571,ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_2792639_2	1131266.ARWQ01000001_gene1119	6.252e-63	221.0	arCOG08639@1|root,arCOG08639@2157|Archaea,41SP8@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2792639_4	1229909.NSED_03250	8.46e-13	68.0	arCOG08753@1|root,arCOG08753@2157|Archaea,41T9W@651137|Thaumarchaeota	651137|Thaumarchaeota	C	4 iron, 4 sulfur cluster binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2792639_1	1229909.NSED_08170	6.431e-90	300.0	arCOG08638@1|root,arCOG08638@2157|Archaea,41T08@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2792639_3	1229909.NSED_08160	3.216e-50	184.0	arCOG08637@1|root,arCOG08637@2157|Archaea,41SV0@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2792639_0	1131266.ARWQ01000001_gene1115	1.574e-170	539.0	COG0214@1|root,arCOG04075@2157|Archaea,41SEJ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the PdxS SNZ family	-	-	4.3.3.6	ko:K06215	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SOR_SNZ
HKD1_k127_2828944_0	1131266.ARWQ01000014_gene89	2.709e-97	321.0	COG0604@1|root,arCOG01458@2157|Archaea,41SX7@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_2828944_2	1229909.NSED_03590	7.258e-28	121.0	COG2259@1|root,arCOG08092@2157|Archaea	2157|Archaea	S	DoxX family	-	-	1.8.5.2	ko:K15977,ko:K16937	ko00920,ko01120,map00920,map01120	-	R07177	-	ko00000,ko00001,ko01000	3.D.4.9	-	-	DoxX
HKD1_k127_2828944_1	227377.CBU_0296	5.406e-56	202.0	COG0461@1|root,COG0461@2|Bacteria,1MVP7@1224|Proteobacteria,1SFH8@1236|Gammaproteobacteria	1236|Gammaproteobacteria	F	Phosphoribosyl transferase domain	-	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_2828944_3	436308.Nmar_0345	7.321e-13	74.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_28395_4	436308.Nmar_0546	1.949e-34	134.0	COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Chorismate mutase type II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2,CM_2
HKD1_k127_28395_2	436308.Nmar_0545	1.046e-120	393.0	COG0722@1|root,arCOG00245@2157|Archaea,41SM0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydrogenase	-	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD1_k127_28395_3	1229909.NSED_02755	8.947e-51	183.0	COG1184@1|root,arCOG01127@2157|Archaea,41T2Z@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_28395_0	436308.Nmar_0543	1.615e-247	768.0	COG0422@1|root,arCOG02741@2157|Archaea,41S5Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Thiamine biosynthesis protein ThiC	-	-	4.1.99.17	ko:K03147	ko00730,ko01100,map00730,map01100	M00127	R03472	RC03251,RC03252	ko00000,ko00001,ko00002,ko01000	-	-	-	ThiC_Rad_SAM
HKD1_k127_28395_1	436308.Nmar_0542	1.079e-130	429.0	COG0351@1|root,arCOG00020@2157|Archaea,41SA1@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Phosphomethylpyrimidine kinase	-	-	2.5.1.3,2.7.1.49,2.7.4.7	ko:K21219	ko00730,ko01100,map00730,map01100	-	R03223,R03471,R04509,R10712	RC00002,RC00017,RC00224,RC03255,RC03397	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin,ThiP_synth
HKD1_k127_2872230_2	644281.MFS40622_0226	8.697e-06	50.0	COG0457@1|root,arCOG03038@2157|Archaea,2XUNW@28890|Euryarchaeota,23R7V@183939|Methanococci	183939|Methanococci	S	PFAM TPR repeat-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_2,TPR_8
HKD1_k127_2872230_1	436308.Nmar_0640	6.141e-41	156.0	arCOG08653@1|root,arCOG08653@2157|Archaea,41T9H@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2872230_0	1229909.NSED_08500	1.163e-61	217.0	arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2883011_3	1131266.ARWQ01000005_gene809	2.342e-15	75.0	COG0719@1|root,arCOG01715@2157|Archaea,41S5W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufB	-	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_2883011_0	1131266.ARWQ01000005_gene810	7.569e-187	594.0	COG0719@1|root,arCOG01715@2157|Archaea,41S7W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	FeS assembly protein SufD	-	-	-	ko:K09014,ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD1_k127_2883011_2	1229909.NSED_02490	1.084e-39	149.0	COG2146@1|root,arCOG02852@2157|Archaea,41T71@651137|Thaumarchaeota	651137|Thaumarchaeota	P	of nitrite reductase and ring-hydroxylating	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD1_k127_2883011_1	1229909.NSED_02495	8.228e-80	269.0	COG0520@1|root,arCOG00065@2157|Archaea,41SCV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD1_k127_2884057_1	1131266.ARWQ01000010_gene57	1.102e-39	149.0	COG0689@1|root,arCOG01575@2157|Archaea,41S81@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'- 5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails	rrp41	-	-	ko:K11600	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_2884057_0	1131266.ARWQ01000010_gene56	9.875e-113	369.0	COG2123@1|root,arCOG01574@2157|Archaea,41SFZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site	rrp42	-	-	ko:K12589	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	RNase_PH,RNase_PH_C
HKD1_k127_2884057_3	436308.Nmar_0434	3.612e-27	111.0	COG1997@1|root,arCOG04208@2157|Archaea,41SUE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal L37ae protein family	rpl37ae	-	-	ko:K02921	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L37ae
HKD1_k127_2884057_2	436308.Nmar_0436	9.138e-32	127.0	COG1382@1|root,arCOG01342@2157|Archaea,41SPD@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdB	-	-	ko:K04798	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin_2
HKD1_k127_2919710_1	436308.Nmar_0412	8.221e-96	319.0	COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_2919710_2	1131266.ARWQ01000012_gene1609	1.523e-23	103.0	arCOG08666@1|root,arCOG08666@2157|Archaea,41SVR@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2919710_0	1131266.ARWQ01000012_gene1608	2.989e-175	559.0	COG0579@1|root,arCOG00754@2157|Archaea,41SXA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	FAD dependent oxidoreductase	-	-	-	ko:K15736	-	-	-	-	ko00000,ko01000	-	-	-	DAO
HKD1_k127_2919710_3	1459636.NTE_02133	2.499e-19	89.0	COG5466@1|root,arCOG05278@2157|Archaea	2157|Archaea	S	small metal-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF1059
HKD1_k127_3007796_3	436308.Nmar_1777	2.175e-37	141.0	COG0846@1|root,arCOG04248@2157|Archaea,41SWP@651137|Thaumarchaeota	651137|Thaumarchaeota	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD1_k127_3007796_0	1131266.ARWQ01000001_gene1350	2.493e-133	430.0	COG1234@1|root,arCOG00501@2157|Archaea,41SF7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B,Lactamase_B_2
HKD1_k127_3007796_2	1229909.NSED_09510	5.673e-84	288.0	COG1041@1|root,arCOG00047@2157|Archaea	2157|Archaea	L	RNA methylase	trmG10	GO:0000049,GO:0001510,GO:0003674,GO:0003676,GO:0003723,GO:0003824,GO:0004809,GO:0005488,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0008168,GO:0008170,GO:0008173,GO:0008175,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016423,GO:0016740,GO:0016741,GO:0030488,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0046483,GO:0071704,GO:0090304,GO:0097159,GO:0140098,GO:0140101,GO:1901360,GO:1901363	2.1.1.213	ko:K07446	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	THUMP,UPF0020
HKD1_k127_3007796_1	1229909.NSED_09505	2.399e-118	387.0	COG0462@1|root,arCOG00067@2157|Archaea,41SH1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Ribose-phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD1_k127_3051792_3	1229909.NSED_01660	5.524e-14	81.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3051792_1	436308.Nmar_0944	9.058e-230	720.0	COG1111@1|root,arCOG00872@2157|Archaea	2157|Archaea	L	DEAD DEAH box helicase domain protein	-	-	-	ko:K03703,ko:K10896	ko03420,ko03460,map03420,map03460	M00413	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	DEAD,ERCC4,HHH_2,HHH_5,Helicase_C,ResIII
HKD1_k127_3051792_2	1229909.NSED_05400	2.756e-86	288.0	COG2131@1|root,arCOG01487@2157|Archaea,41SHS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	MafB19-like deaminase	-	-	3.5.4.12	ko:K01493	ko00240,ko01100,map00240,map01100	M00429	R01663	RC00074	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	dCMP_cyt_deam_1
HKD1_k127_3051792_0	1229909.NSED_05405	0.0	1223.0	COG0417@1|root,arCOG15272@2157|Archaea,41S91@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA polymerase	-	-	2.7.7.7	ko:K02319	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_pol_B,DNA_pol_B_exo1
HKD1_k127_3068793_3	1122915.AUGY01000048_gene5173	6.036e-06	55.0	COG1276@1|root,COG2372@1|root,COG1276@2|Bacteria,COG2372@2|Bacteria,1V0AI@1239|Firmicutes,4HCGR@91061|Bacilli,275GS@186822|Paenibacillaceae	91061|Bacilli	P	CopC domain	-	-	-	ko:K14166	-	-	-	-	ko00000,ko02000	-	-	-	CopC,CopD
HKD1_k127_3068793_0	1229909.NSED_09225	9.123e-104	347.0	COG0430@1|root,arCOG04125@2157|Archaea,41T1K@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	-	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC
HKD1_k127_3068793_1	436308.Nmar_1732	2.925e-62	218.0	COG1056@1|root,arCOG00972@2157|Archaea,41T7B@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Cytidylyltransferase-like	-	-	2.7.7.1	ko:K00952	ko00760,ko01100,map00760,map01100	-	R00137,R03005	RC00002	ko00000,ko00001,ko01000	-	-	-	CTP_transf_like
HKD1_k127_3068793_2	1229909.NSED_09215	3.018e-09	58.0	COG0075@1|root,arCOG00082@2157|Archaea,41SZZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_3089879_0	1229909.NSED_06780	4.359e-51	185.0	COG1331@1|root,arCOG02007@2157|Archaea,41SHZ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Protein of unknown function, DUF255	-	-	-	ko:K06888	-	-	-	-	ko00000	-	-	-	Thioredox_DsbH
HKD1_k127_3089879_1	1131266.ARWQ01000035_gene718	5.553e-37	142.0	arCOG08080@1|root,arCOG08080@2157|Archaea,41SUA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3089879_2	436308.Nmar_1636	1.827e-27	121.0	arCOG08812@1|root,arCOG08812@2157|Archaea	436308.Nmar_1636|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_314865_4	1459636.NTE_00041	4.986e-07	51.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	2157|Archaea	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
HKD1_k127_314865_1	1229909.NSED_02415	7.625e-71	245.0	COG1392@1|root,arCOG02640@2157|Archaea,41SKJ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Protein of unknown function DUF47	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD1_k127_314865_0	1459636.NTE_00865	2.953e-121	397.0	COG0306@1|root,arCOG02267@2157|Archaea,41SD8@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate transporter family	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD1_k127_314865_2	1459636.NTE_00050	4.521e-24	109.0	COG0248@1|root,arCOG05138@2157|Archaea	2157|Archaea	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HKD1_k127_3177396_2	436308.Nmar_0756	2.082e-42	158.0	arCOG05565@1|root,arCOG05565@2157|Archaea,41T3I@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177396_4	1459636.NTE_01688	1.719e-31	126.0	COG3269@1|root,arCOG01641@2157|Archaea	2157|Archaea	J	RNA-binding protein contains TRAM domain	-	-	-	-	-	-	-	-	-	-	-	-	TRAM
HKD1_k127_3177396_3	1131266.ARWQ01000001_gene1337	5.301e-38	146.0	COG3432@1|root,arCOG01055@2157|Archaea,41T3P@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
HKD1_k127_3177396_0	1131266.ARWQ01000001_gene1336	2.453e-69	250.0	COG2512@1|root,arCOG00374@2157|Archaea,41SUX@651137|Thaumarchaeota	651137|Thaumarchaeota	K	membrane-associated protein domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177396_7	1229909.NSED_09800	1.092e-11	75.0	arCOG10414@1|root,arCOG10414@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177396_5	1131266.ARWQ01000001_gene1334	2.38e-19	88.0	arCOG08815@1|root,arCOG08815@2157|Archaea,41T9N@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177396_6	1229909.NSED_02355	2.571e-15	87.0	arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3177396_1	521011.Mpal_1474	1.047e-56	211.0	COG0614@1|root,arCOG03561@1|root,arCOG03561@2157|Archaea,arCOG03611@2157|Archaea,2Y1Q9@28890|Euryarchaeota,2N9M9@224756|Methanomicrobia	224756|Methanomicrobia	P	PFAM NHL repeat containing protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgD_ig,NHL
HKD1_k127_3190008_2	1131266.ARWQ01000002_gene472	4.076e-39	149.0	COG0547@1|root,arCOG02012@2157|Archaea,41SGG@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD1_k127_3190008_1	436308.Nmar_0914	4.085e-93	312.0	COG0134@1|root,arCOG01088@2157|Archaea,41SN7@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Indole-3-glycerol phosphate synthase	-	-	4.1.1.48	ko:K01609	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508	RC00944	ko00000,ko00001,ko00002,ko01000	-	-	-	IGPS
HKD1_k127_3190008_0	436308.Nmar_0915	2.505e-172	544.0	COG0133@1|root,arCOG01433@2157|Archaea,41S87@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3239931_2	1229909.NSED_09360	2.838e-38	146.0	arCOG08749@1|root,arCOG08749@2157|Archaea,41SRV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3239931_4	1459636.NTE_03029	3.054e-16	79.0	arCOG08748@1|root,arCOG08748@2157|Archaea,41SV7@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3239931_0	436308.Nmar_1760	7.034e-75	255.0	COG2453@1|root,arCOG03413@2157|Archaea,41SK5@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Dual specificity phosphatase, catalytic domain	-	-	3.1.3.16,3.1.3.48	ko:K14165	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	DSPc
HKD1_k127_3239931_1	1229909.NSED_09420	2.156e-62	216.0	COG1145@1|root,arCOG00291@2157|Archaea,41T34@651137|Thaumarchaeota	651137|Thaumarchaeota	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_3239931_3	1459636.NTE_00421	2.122e-28	116.0	COG0760@1|root,arCOG07441@2157|Archaea,41SSK@651137|Thaumarchaeota	651137|Thaumarchaeota	O	PPIC-type PPIASE domain	-	-	5.2.1.8	ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_3
HKD1_k127_3285356_2	43759.JNWK01000056_gene1693	5.747e-12	72.0	COG0517@1|root,COG0517@2|Bacteria,2IM3K@201174|Actinobacteria	201174|Actinobacteria	S	Cbs domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_3285356_0	1229909.NSED_07230	5.289e-73	250.0	arCOG08805@1|root,arCOG08805@2157|Archaea,41T3X@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3285356_1	436308.Nmar_1665	2.636e-31	128.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD1_k127_3323418_2	436308.Nmar_0412	1.876e-12	67.0	COG1052@1|root,arCOG01755@2157|Archaea,41T1D@651137|Thaumarchaeota	651137|Thaumarchaeota	C	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.26	ko:K00015	ko00630,ko01100,ko01110,ko01120,map00630,map01100,map01110,map01120	-	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3323418_0	1229909.NSED_02150	4.113e-220	692.0	COG0674@1|root,arCOG01606@2157|Archaea,41S60@651137|Thaumarchaeota	651137|Thaumarchaeota	C	pyruvate flavodoxin ferredoxin oxidoreductase	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD1_k127_3395161_2	1230457.C476_10352	2.216e-06	54.0	COG0640@1|root,arCOG03065@2157|Archaea,2XY3J@28890|Euryarchaeota,23WD0@183963|Halobacteria	183963|Halobacteria	K	Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_3395161_3	1230460.C495_05678	0.0006191	46.0	arCOG03915@1|root,arCOG03915@2157|Archaea,2XZRQ@28890|Euryarchaeota,23XHM@183963|Halobacteria	183963|Halobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3395161_1	1459636.NTE_01471	6.95e-60	224.0	COG0642@1|root,arCOG02358@2157|Archaea,41T39@651137|Thaumarchaeota	651137|Thaumarchaeota	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_3395161_0	436308.Nmar_1680	1.42e-74	261.0	COG0697@1|root,arCOG00273@2157|Archaea,41T37@651137|Thaumarchaeota	651137|Thaumarchaeota	G	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_3397138_3	330214.NIDE3875	9.657e-12	66.0	COG1014@1|root,COG1144@1|root,COG1014@2|Bacteria,COG1144@2|Bacteria,3J0TG@40117|Nitrospirae	40117|Nitrospirae	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	-	-	1.2.7.1	ko:K00172	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_3397138_0	1229909.NSED_07235	2.159e-29	120.0	COG0640@1|root,arCOG03067@2157|Archaea,41TA3@651137|Thaumarchaeota	651137|Thaumarchaeota	K	transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3397138_1	436308.Nmar_1481	2.014e-26	119.0	COG0517@1|root,arCOG00600@2157|Archaea,41TAT@651137|Thaumarchaeota	651137|Thaumarchaeota	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_3397138_2	1121938.AUDY01000012_gene3804	7.099e-13	77.0	COG0589@1|root,COG0589@2|Bacteria,1VEJR@1239|Firmicutes,4I3ZQ@91061|Bacilli,3NG2S@45667|Halobacillus	91061|Bacilli	T	Universal stress protein family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3405643_0	436308.Nmar_0193	1.457e-209	660.0	COG0527@1|root,arCOG00861@2157|Archaea,41SFK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Amino acid kinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_3405643_1	1229909.NSED_00440	3.904e-11	65.0	arCOG11526@1|root,arCOG11526@2157|Archaea,41T9E@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3414600_4	1459636.NTE_01015	3.305e-15	82.0	arCOG08733@1|root,arCOG08733@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3414600_2	1229909.NSED_02365	1.799e-48	178.0	arCOG10527@1|root,arCOG10527@2157|Archaea,41SPB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3414600_0	1131266.ARWQ01000010_gene32	1.314e-88	296.0	arCOG08734@1|root,arCOG08734@2157|Archaea,41SP9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3414600_3	1131266.ARWQ01000010_gene25	2.848e-26	111.0	arCOG07802@1|root,arCOG07802@2157|Archaea,41T6C@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pfam:DUF385	-	-	-	-	-	-	-	-	-	-	-	-	F420H2_quin_red
HKD1_k127_3414600_1	1229909.NSED_02390	4.885e-56	199.0	arCOG08735@1|root,arCOG08735@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3423535_1	1229909.NSED_08330	3.886e-86	287.0	COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5
HKD1_k127_3423535_0	1229909.NSED_08335	1.4e-216	682.0	COG2304@1|root,arCOG02900@2157|Archaea,41SDY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	von Willebrand factor (vWF) type A domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3431807_2	436308.Nmar_1103	1.093e-62	217.0	COG0322@1|root,arCOG04753@2157|Archaea,41SX9@651137|Thaumarchaeota	651137|Thaumarchaeota	L	TIGRFAM excinuclease ABC, C subunit	-	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,UVR,UvrC_HhH_N
HKD1_k127_3431807_0	1229909.NSED_06410	0.0	1480.0	COG0178@1|root,arCOG04694@2157|Archaea,41T01@651137|Thaumarchaeota	651137|Thaumarchaeota	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_3431807_1	1229909.NSED_06415	8.654e-219	686.0	COG0556@1|root,arCOG04748@2157|Archaea,41T0H@651137|Thaumarchaeota	651137|Thaumarchaeota	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_3458254_2	1229909.NSED_00750	9.378e-56	196.0	COG0139@1|root,arCOG02676@2157|Archaea,41SPE@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HKD1_k127_3458254_3	1229909.NSED_00755	7.119e-21	98.0	arCOG08828@1|root,arCOG08828@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3458254_0	436308.Nmar_1549	9.823e-223	695.0	COG0498@1|root,arCOG01434@2157|Archaea,41SEI@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_3458254_1	436308.Nmar_1548	1.228e-207	652.0	COG0476@1|root,COG1977@1|root,arCOG00536@2157|Archaea,arCOG01676@2157|Archaea,41S5X@651137|Thaumarchaeota	651137|Thaumarchaeota	H	ThiF family	-	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF,ThiS
HKD1_k127_3512710_1	1229909.NSED_00425	4.758e-48	178.0	COG0642@1|root,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_3512710_0	1459636.NTE_00579	1.37e-100	334.0	COG0663@1|root,arCOG01849@2157|Archaea	2157|Archaea	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	ko:K08698	-	-	-	-	ko00000	-	-	-	Hexapep
HKD1_k127_3512710_2	1131266.ARWQ01000004_gene1470	1.041e-28	119.0	arCOG00516@1|root,arCOG00516@2157|Archaea,41SQT@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate oxidase	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD1_k127_351883_2	1229909.NSED_09120	1.919e-68	236.0	COG1136@1|root,arCOG00922@2157|Archaea,41T2R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	ABC-type antimicrobial peptide transport system, ATPase component	-	-	-	ko:K02003,ko:K09810	ko02010,map02010	M00255,M00258	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1,3.A.1.125	-	-	ABC_tran
HKD1_k127_351883_1	1229909.NSED_09115	4.971e-79	284.0	COG1361@1|root,arCOG02080@2157|Archaea,41T6N@651137|Thaumarchaeota	651137|Thaumarchaeota	M	extracellular matrix structural constituent	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_351883_3	436308.Nmar_1710	1.407e-48	177.0	arCOG03681@1|root,arCOG03681@2157|Archaea,41T6V@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_351883_0	436308.Nmar_1709	1.698e-215	679.0	COG0661@1|root,arCOG01189@2157|Archaea,41SYQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ABC1 family	-	-	-	-	-	-	-	-	-	-	-	-	ABC1
HKD1_k127_351883_4	1449355.JQNR01000004_gene1305	2.694e-12	79.0	COG3693@1|root,COG4733@1|root,COG3693@2|Bacteria,COG4733@2|Bacteria,2GJSN@201174|Actinobacteria	201174|Actinobacteria	G	PFAM glycoside hydrolase, family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM_2,CBM_3,Glyco_hydro_10,fn3
HKD1_k127_3548518_3	1459636.NTE_01667	4.17e-19	91.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3548518_2	1459636.NTE_00321	1.407e-20	92.0	arCOG11305@1|root,arCOG11305@2157|Archaea,41T7G@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3548518_4	1459636.NTE_00321	3.95e-05	46.0	arCOG11305@1|root,arCOG11305@2157|Archaea,41T7G@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3548518_5	1229909.NSED_02355	0.0004725	51.0	arCOG08733@1|root,arCOG08733@2157|Archaea,41SRN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3548518_0	436308.Nmar_1488	5.859e-188	602.0	COG0072@1|root,arCOG00412@2157|Archaea,41S8M@651137|Thaumarchaeota	651137|Thaumarchaeota	J	phenylalanyl-tRNA synthetase, beta subunit	-	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5
HKD1_k127_3548518_1	565033.GACE_1854	6.963e-36	139.0	COG0016@1|root,arCOG00410@2157|Archaea,2XSTK@28890|Euryarchaeota,245SE@183980|Archaeoglobi	183980|Archaeoglobi	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2d
HKD1_k127_3651409_1	436308.Nmar_0868	2.236e-90	303.0	COG0064@1|root,arCOG01718@2157|Archaea,41S9S@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_3651409_2	644282.Deba_0919	5.762e-05	51.0	COG3576@1|root,COG3576@2|Bacteria,1PKS2@1224|Proteobacteria,42T45@68525|delta/epsilon subdivisions,2WPSR@28221|Deltaproteobacteria	28221|Deltaproteobacteria	T	pyridoxamine 5'-phosphate oxidase-related FMN-binding	-	-	-	ko:K07006	-	-	-	-	ko00000	-	-	-	Putative_PNPOx
HKD1_k127_3651409_0	436308.Nmar_0588	7.897e-101	332.0	COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_3669982_0	1229909.NSED_04760	4.421e-54	196.0	COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
HKD1_k127_3669982_1	192952.MM_1678	6.056e-12	74.0	COG1989@1|root,arCOG02298@2157|Archaea,2XUQP@28890|Euryarchaeota,2N9XX@224756|Methanomicrobia	224756|Methanomicrobia	N	Peptidase A24A, prepilin type IV	-	-	3.4.23.52	ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
HKD1_k127_3707071_0	368408.Tpen_0445	3.963e-21	102.0	COG2064@1|root,arCOG01808@2157|Archaea,2XQ18@28889|Crenarchaeota	28889|Crenarchaeota	N	PFAM type II secretion system	-	-	-	ko:K07333	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSF
HKD1_k127_3727615_0	1459636.NTE_02221	2.686e-142	456.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_3727615_1	1459636.NTE_03073	1.779e-58	208.0	arCOG08805@1|root,arCOG08805@2157|Archaea	1459636.NTE_03073|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_373146_0	1229909.NSED_01670	6.999e-317	973.0	COG0085@1|root,arCOG01762@2157|Archaea,41SF5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	-	-	2.7.7.6	ko:K13798	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_4,RNA_pol_Rpb2_5,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_373146_1	1229909.NSED_01665	1.405e-37	142.0	COG2012@1|root,arCOG04258@2157|Archaea,41SU8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoH	-	2.7.7.6	ko:K03053	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb5_C
HKD1_k127_3743482_2	1229909.NSED_01290	2.169e-34	132.0	COG0852@1|root,arCOG01551@2157|Archaea,41SJS@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH ubiquinone oxidoreductase 27 kD subunit	-	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD1_k127_3743482_0	1131266.ARWQ01000008_gene335	4.514e-208	650.0	COG0649@1|root,arCOG01548@2157|Archaea,41S62@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD1_k127_3743482_1	1229909.NSED_01300	1.203e-90	301.0	COG1005@1|root,arCOG01546@2157|Archaea,41SAT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_3755_0	436308.Nmar_1009	3.513e-14	81.0	arCOG10568@1|root,arCOG10568@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3760846_0	7918.ENSLOCP00000007693	3.75e-17	90.0	KOG0613@1|root,KOG0613@2759|Eukaryota,38BAS@33154|Opisthokonta,3B9IR@33208|Metazoa,3CRJW@33213|Bilateria,484DC@7711|Chordata,48Y8I@7742|Vertebrata,4A1S0@7898|Actinopterygii	33208|Metazoa	T	Titin-like	TTN	GO:0000070,GO:0000228,GO:0000278,GO:0000280,GO:0000793,GO:0000794,GO:0000819,GO:0001701,GO:0001756,GO:0001932,GO:0002020,GO:0002576,GO:0002791,GO:0002793,GO:0003002,GO:0003007,GO:0003008,GO:0003012,GO:0003013,GO:0003015,GO:0003300,GO:0003674,GO:0003779,GO:0003824,GO:0004672,GO:0004674,GO:0004713,GO:0005198,GO:0005200,GO:0005488,GO:0005509,GO:0005515,GO:0005516,GO:0005575,GO:0005576,GO:0005622,GO:0005623,GO:0005634,GO:0005694,GO:0005737,GO:0005829,GO:0005856,GO:0005859,GO:0005865,GO:0006323,GO:0006464,GO:0006468,GO:0006793,GO:0006796,GO:0006807,GO:0006810,GO:0006887,GO:0006928,GO:0006936,GO:0006941,GO:0006996,GO:0007010,GO:0007015,GO:0007049,GO:0007059,GO:0007076,GO:0007154,GO:0007165,GO:0007275,GO:0007389,GO:0007399,GO:0007417,GO:0007420,GO:0007507,GO:0007512,GO:0007517,GO:0008015,GO:0008092,GO:0008150,GO:0008152,GO:0008307,GO:0009581,GO:0009582,GO:0009605,GO:0009612,GO:0009628,GO:0009653,GO:0009790,GO:0009792,GO:0009887,GO:0009888,GO:0009893,GO:0009952,GO:0009987,GO:0010035,GO:0010038,GO:0010468,GO:0010604,GO:0010628,GO:0010737,GO:0010927,GO:0014706,GO:0014866,GO:0014896,GO:0014897,GO:0015629,GO:0016043,GO:0016192,GO:0016301,GO:0016310,GO:0016459,GO:0016460,GO:0016740,GO:0016772,GO:0016773,GO:0018108,GO:0018193,GO:0018212,GO:0019220,GO:0019222,GO:0019538,GO:0019899,GO:0019900,GO:0019901,GO:0021591,GO:0022402,GO:0022607,GO:0023052,GO:0030016,GO:0030017,GO:0030018,GO:0030029,GO:0030036,GO:0030048,GO:0030049,GO:0030154,GO:0030239,GO:0030240,GO:0030241,GO:0030261,GO:0030506,GO:0031032,GO:0031033,GO:0031034,GO:0031323,GO:0031399,GO:0031430,GO:0031433,GO:0031672,GO:0031674,GO:0031974,GO:0031981,GO:0032268,GO:0032501,GO:0032502,GO:0032879,GO:0032880,GO:0032940,GO:0032989,GO:0032991,GO:0033058,GO:0033275,GO:0034622,GO:0035051,GO:0035265,GO:0035282,GO:0035556,GO:0035994,GO:0035995,GO:0036211,GO:0036379,GO:0040007,GO:0040011,GO:0042221,GO:0042325,GO:0042692,GO:0042802,GO:0042805,GO:0043009,GO:0043056,GO:0043167,GO:0043169,GO:0043170,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043233,GO:0043292,GO:0043412,GO:0043549,GO:0043621,GO:0043933,GO:0044057,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044422,GO:0044424,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044449,GO:0044464,GO:0044877,GO:0045055,GO:0045214,GO:0045859,GO:0046872,GO:0046903,GO:0048285,GO:0048468,GO:0048513,GO:0048518,GO:0048522,GO:0048589,GO:0048644,GO:0048646,GO:0048729,GO:0048731,GO:0048738,GO:0048739,GO:0048747,GO:0048769,GO:0048856,GO:0048869,GO:0050708,GO:0050714,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0050982,GO:0051015,GO:0051046,GO:0051047,GO:0051049,GO:0051050,GO:0051146,GO:0051171,GO:0051174,GO:0051179,GO:0051222,GO:0051223,GO:0051234,GO:0051239,GO:0051246,GO:0051276,GO:0051338,GO:0051371,GO:0051393,GO:0051592,GO:0051606,GO:0051716,GO:0055001,GO:0055002,GO:0055003,GO:0055006,GO:0055007,GO:0055008,GO:0055013,GO:0060047,GO:0060048,GO:0060255,GO:0060322,GO:0060415,GO:0060419,GO:0060429,GO:0060537,GO:0061053,GO:0061061,GO:0065003,GO:0065007,GO:0065009,GO:0070013,GO:0070201,GO:0070252,GO:0070925,GO:0071103,GO:0071688,GO:0071704,GO:0071840,GO:0072359,GO:0080090,GO:0090087,GO:0090257,GO:0097435,GO:0097493,GO:0098813,GO:0099080,GO:0099081,GO:0099512,GO:0140014,GO:0140096,GO:1901077,GO:1901564,GO:1901897,GO:1903047,GO:1903530,GO:1903532,GO:1904951	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	I-set,Ig_2,Ig_3,PPAK,Pkinase,Titin_Z,fn3,ig
HKD1_k127_3780587_1	1229909.NSED_00675	2.311e-56	202.0	COG1096@1|root,arCOG00676@2157|Archaea,41SQA@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs	csl4	-	-	ko:K07573	ko03018,map03018	M00390,M00391	-	-	ko00000,ko00001,ko00002,ko03019	-	-	-	-
HKD1_k127_3780587_0	1131266.ARWQ01000003_gene1582	2.305e-117	383.0	COG0077@1|root,arCOG00255@2157|Archaea,41SA8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Prephenate dehydratase	-	-	4.2.1.51	ko:K04518	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00024	R00691,R01373	RC00360	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PDT
HKD1_k127_3780587_2	1131266.ARWQ01000003_gene1583	1.68e-05	47.0	arCOG08827@1|root,arCOG08827@2157|Archaea,41SUW@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3825562_0	436308.Nmar_1120	1.048e-221	698.0	COG0060@1|root,arCOG00807@2157|Archaea,41SFF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	-	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_3825562_2	1229909.NSED_06500	9.459e-39	147.0	arCOG08645@1|root,arCOG08645@2157|Archaea,41STW@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3825562_1	1229909.NSED_06505	5.48e-168	534.0	COG0045@1|root,arCOG01337@2157|Archaea,41S5M@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ATP-grasp domain	-	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD1_k127_3874288_0	1131266.ARWQ01000004_gene1484	1.031e-162	518.0	COG0473@1|root,arCOG01163@2157|Archaea,41S5U@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Isocitrate isopropylmalate dehydrogenase	-	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_3874288_2	1229909.NSED_07505	2.719e-121	393.0	COG1409@1|root,arCOG01153@2157|Archaea,41SF2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_3874288_7	1131266.ARWQ01000004_gene1482	8.049e-12	69.0	arCOG10403@1|root,arCOG10403@2157|Archaea,41TB3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3874288_5	1131266.ARWQ01000004_gene1480	1.855e-21	95.0	COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HKD1_k127_3874288_3	436308.Nmar_1368	1.557e-79	269.0	COG0457@1|root,arCOG03038@2157|Archaea,41SMV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	TPR_9,Transglut_core2
HKD1_k127_3874288_1	436308.Nmar_1367	1.009e-144	468.0	arCOG08650@1|root,arCOG08650@2157|Archaea,41SZ5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3874288_8	443255.SCLAV_5543	3.592e-06	59.0	COG1807@1|root,COG1807@2|Bacteria,2H008@201174|Actinobacteria	201174|Actinobacteria	M	Dolichyl-phosphate-mannose-protein mannosyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PMT,PMT_2
HKD1_k127_3874288_9	436308.Nmar_0460	0.0002445	46.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
HKD1_k127_3874288_6	933801.Ahos_0540	3.433e-21	98.0	COG0589@1|root,arCOG02053@2157|Archaea,2XQTK@28889|Crenarchaeota	28889|Crenarchaeota	T	PFAM UspA domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3874288_4	1229909.NSED_08800	8.436e-25	106.0	arCOG06947@1|root,arCOG06947@2157|Archaea,41TAK@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3888155_1	1131266.ARWQ01000001_gene1337	1.9e-25	108.0	COG3432@1|root,arCOG01055@2157|Archaea,41T3P@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
HKD1_k127_3888155_0	402626.Rpic_3979	6.947e-81	280.0	COG1502@1|root,COG1502@2|Bacteria,1R9CI@1224|Proteobacteria,2WFC7@28216|Betaproteobacteria,1KI0D@119060|Burkholderiaceae	28216|Betaproteobacteria	I	PLD-like domain	-	-	-	-	-	-	-	-	-	-	-	-	PLDc_2
HKD1_k127_3895230_0	1229909.NSED_03795	3.342e-157	508.0	arCOG08801@1|root,arCOG08801@2157|Archaea	2157|Archaea	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3895230_4	255470.cbdbA1365	3.397e-11	74.0	COG4249@1|root,COG4249@2|Bacteria,2GARQ@200795|Chloroflexi,34D6K@301297|Dehalococcoidia	301297|Dehalococcoidia	S	Peptidase C13 family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14
HKD1_k127_3895230_2	1229909.NSED_01660	2.331e-27	117.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3895230_3	1131266.ARWQ01000002_gene483	1.46e-21	96.0	arCOG10573@1|root,arCOG10573@2157|Archaea,41T8W@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3895230_1	1459636.NTE_03444	2.486e-127	417.0	COG1752@1|root,arCOG09020@2157|Archaea	2157|Archaea	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_3927491_1	1229909.NSED_09075	1.412e-106	349.0	COG0528@1|root,arCOG00858@2157|Archaea,41T1R@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_3927491_0	436308.Nmar_1706	1.095e-173	553.0	COG1078@1|root,arCOG04430@2157|Archaea,41T0P@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06885	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_3927491_2	436308.Nmar_1707	2.922e-64	225.0	COG0125@1|root,arCOG01891@2157|Archaea,41T33@651137|Thaumarchaeota	651137|Thaumarchaeota	F	thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_3927491_3	436308.Nmar_1708	2.078e-21	95.0	COG0071@1|root,arCOG01832@2157|Archaea,41T74@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	HSP20
HKD1_k127_3928700_4	436308.Nmar_0762	7.712e-15	75.0	arCOG10546@1|root,arCOG10546@2157|Archaea,41SRD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3928700_1	1229909.NSED_05760	2.71e-86	293.0	arCOG01792@1|root,arCOG01792@2157|Archaea,41SFY@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_3928700_5	1229909.NSED_06045	3.01e-10	62.0	arCOG08679@1|root,arCOG08679@2157|Archaea	2157|Archaea	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3928700_2	386456.JQKN01000014_gene3081	3.48e-56	202.0	COG0586@1|root,arCOG03117@2157|Archaea,2XY9U@28890|Euryarchaeota	28890|Euryarchaeota	S	PFAM SNARE associated Golgi protein	-	-	-	ko:K03975	-	-	-	-	ko00000	-	-	-	SNARE_assoc
HKD1_k127_3928700_3	1131266.ARWQ01000002_gene601	1.725e-27	114.0	COG1656@1|root,arCOG04290@2157|Archaea,41T6F@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Mut7-C RNAse domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3928700_0	1131266.ARWQ01000001_gene1198	2.649e-118	386.0	COG0598@1|root,arCOG02265@2157|Archaea	2157|Archaea	P	Mediates influx of magnesium ions	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD1_k127_3987701_3	436308.Nmar_0953	9.971e-43	157.0	COG0346@1|root,arCOG02706@2157|Archaea,41SQS@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_3987701_1	1229909.NSED_05425	5.018e-71	244.0	COG3620@1|root,arCOG00608@2157|Archaea,41SJR@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_3
HKD1_k127_3987701_5	879305.HMPREF9290_1071	1.097e-13	76.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,22HFM@1570339|Peptoniphilaceae	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_3987701_0	436308.Nmar_0950	2.531e-92	308.0	COG0149@1|root,arCOG01087@2157|Archaea,41SHT@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD1_k127_3987701_6	436308.Nmar_0861	0.0003898	47.0	arCOG10555@1|root,arCOG10555@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3987701_4	1459636.NTE_02437	8.001e-20	89.0	COG1552@1|root,arCOG04049@2157|Archaea,41T87@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL40 family	-	-	-	ko:K02927	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
HKD1_k127_3987701_2	1131266.ARWQ01000014_gene86	3.825e-55	195.0	COG0074@1|root,arCOG01339@2157|Archaea,41SEU@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD1_k127_3994963_1	1229909.NSED_07475	2.495e-79	274.0	COG0500@1|root,COG2835@1|root,arCOG01791@2157|Archaea,arCOG04124@2157|Archaea,41T4S@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3994963_0	1229909.NSED_08545	3.883e-150	488.0	arCOG11548@1|root,arCOG11548@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3994963_2	1459636.NTE_02424	1.837e-46	171.0	COG0239@1|root,arCOG04701@2157|Archaea,41T4U@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD1_k127_3999652_2	1459636.NTE_02941	1.502e-23	106.0	COG0784@1|root,arCOG02391@2157|Archaea,41T5D@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_3999652_0	1459636.NTE_01927	7.571e-48	190.0	COG0642@1|root,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1,sCache_3_3
HKD1_k127_3999652_3	1459636.NTE_02941	2.062e-22	103.0	COG0784@1|root,arCOG02391@2157|Archaea,41T5D@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Response regulator with CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD1_k127_3999652_1	306281.AJLK01000073_gene2590	1.093e-44	180.0	COG0457@1|root,COG1484@1|root,COG0457@2|Bacteria,COG1484@2|Bacteria,1G20P@1117|Cyanobacteria	1117|Cyanobacteria	O	tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1,TPR_11,TPR_2,TPR_8
HKD1_k127_4005402_3	1131266.ARWQ01000001_gene1173	6.02e-09	57.0	COG1814@1|root,arCOG01096@2157|Archaea,41T13@651137|Thaumarchaeota	651137|Thaumarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_4005402_0	1131266.ARWQ01000001_gene1174	2.2e-307	946.0	COG1032@1|root,arCOG01357@2157|Archaea,41S86@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_4005402_1	1131266.ARWQ01000001_gene1175	8.314e-37	143.0	arCOG06055@1|root,arCOG06055@2157|Archaea,41SQ3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4005402_2	436308.Nmar_0345	7.323e-15	76.0	arCOG08643@1|root,arCOG08716@1|root,arCOG08643@2157|Archaea,arCOG08716@2157|Archaea,41T3H@651137|Thaumarchaeota	651137|Thaumarchaeota	S	peptidyl-tyrosine sulfation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4032269_1	436308.Nmar_0372	1.799e-37	152.0	COG0642@1|root,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	2.7.13.3	ko:K07709	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA
HKD1_k127_4032269_0	436308.Nmar_1312	1.515e-115	376.0	COG0334@1|root,arCOG01352@2157|Archaea,41S7T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.3	ko:K00261	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_4061877_1	1131266.ARWQ01000005_gene808	3.016e-98	325.0	COG1587@1|root,arCOG02048@2157|Archaea,41SN2@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Uroporphyrinogen-III synthase HemD	-	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD1_k127_4061877_0	436308.Nmar_0492	1.4e-117	381.0	COG0007@1|root,arCOG00644@2157|Archaea,41S9J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the precorrin methyltransferase family	-	-	2.1.1.107	ko:K02303	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03194	RC00003,RC00871	ko00000,ko00001,ko00002,ko01000	-	-	-	TP_methylase
HKD1_k127_4061877_2	436308.Nmar_0491	9.567e-35	136.0	COG0181@1|root,arCOG04299@2157|Archaea,41S6Z@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD1_k127_4072914_2	1437882.AZRU01000039_gene4637	4.377e-07	55.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,1TCA7@1236|Gammaproteobacteria,1YK48@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4072914_0	1173020.Cha6605_1913	3.205e-131	432.0	COG4320@1|root,COG4320@2|Bacteria,1G0BG@1117|Cyanobacteria	1117|Cyanobacteria	S	Uncharacterized protein conserved in bacteria (DUF2252)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2252
HKD1_k127_4072914_1	1229909.NSED_06525	3.887e-47	175.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
HKD1_k127_4101510_1	436308.Nmar_1745	4.109e-98	323.0	COG0524@1|root,arCOG00014@2157|Archaea,41SX4@651137|Thaumarchaeota	651137|Thaumarchaeota	G	pfkB family carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD1_k127_4101510_3	1229909.NSED_09295	3.951e-51	183.0	arCOG08766@1|root,arCOG08766@2157|Archaea,41T41@651137|Thaumarchaeota	651137|Thaumarchaeota	G	dUTPase	-	-	-	-	-	-	-	-	-	-	-	-	dUTPase_2
HKD1_k127_4101510_4	1229909.NSED_09300	3.277e-47	174.0	COG4063@1|root,arCOG03220@2157|Archaea,41T46@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrahydromethanopterin S-methyltransferase, subunit A	-	-	2.1.1.86	ko:K00577	ko00680,ko01100,ko01120,ko01200,map00680,map01100,map01120,map01200	M00357,M00567	R04347	RC00035,RC00113,RC02892	ko00000,ko00001,ko00002,ko01000	-	-	-	MtrA
HKD1_k127_4101510_0	1229909.NSED_09305	2.71e-148	477.0	COG0399@1|root,arCOG00118@2157|Archaea,41S96@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the DegT DnrJ EryC1 family	-	-	-	-	-	-	-	-	-	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_4101510_2	1229909.NSED_09310	5.561e-56	200.0	arCOG08765@1|root,arCOG08765@2157|Archaea,41SQJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4113574_1	1459636.NTE_02368	7.948e-11	67.0	COG1989@1|root,arCOG02298@2157|Archaea	2157|Archaea	NOU	Peptidase A24A, prepilin type IV	pibD	-	3.4.23.43,3.4.23.52	ko:K02278,ko:K07991	-	-	-	-	ko00000,ko01000,ko01002,ko02035,ko02044	-	-	-	Arc_PepC_II,Peptidase_A24
HKD1_k127_4113574_0	1229909.NSED_05300	9.761e-61	219.0	COG1378@1|root,arCOG02038@2157|Archaea	2157|Archaea	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	Regulator_TrmB,TrmB
HKD1_k127_4178519_3	1229909.NSED_07165	1.212e-93	309.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_4178519_2	1131266.ARWQ01000004_gene1454	5.845e-133	427.0	COG0548@1|root,arCOG00862@2157|Archaea,41SFB@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis)	lysZ	-	-	ko:K05828	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09776,R10930	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_4178519_0	1229909.NSED_07155	2.633e-193	606.0	COG0002@1|root,arCOG00495@2157|Archaea,41S8R@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily	lysY	-	-	ko:K05829	ko00220,ko00300,ko01100,ko01110,ko01210,ko01230,map00220,map00300,map01100,map01110,map01210,map01230	M00031,M00763	R09777,R10931	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_4178519_1	1229909.NSED_07150	6.568e-136	436.0	COG0189@1|root,arCOG01589@2157|Archaea,41SCQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Lysine biosynthesis	-	-	6.3.2.43	ko:K05827	ko00300,ko01100,ko01210,ko01230,map00300,map01100,map01210,map01230	M00031	R09775	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	RimK
HKD1_k127_4230983_3	436308.Nmar_0957	2.702e-35	137.0	COG0308@1|root,arCOG02969@2157|Archaea,41SJH@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase family M1 domain	-	-	3.4.11.2	ko:K01256,ko:K13722	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	ERAP1_C,Peptidase_M1
HKD1_k127_4230983_2	98439.AJLL01000036_gene2757	8.989e-39	160.0	COG0025@1|root,COG0025@2|Bacteria,1G1WP@1117|Cyanobacteria,1JGWR@1189|Stigonemataceae	1117|Cyanobacteria	P	Sodium/hydrogen exchanger family	-	-	-	ko:K03316	-	-	-	-	ko00000	2.A.36	-	-	Na_H_Exchanger
HKD1_k127_4230983_0	1283284.AZUK01000001_gene56	9.677e-139	445.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,1RM9U@1236|Gammaproteobacteria,1Y606@135624|Aeromonadales	135624|Aeromonadales	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD1_k127_4230983_1	1131266.ARWQ01000002_gene637	1.321e-61	222.0	COG0457@1|root,arCOG03038@2157|Archaea,41SRQ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Anaphase-promoting complex, cyclosome, subunit 3	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_4230983_4	2850.Phatr44225	2.433e-12	77.0	COG5023@1|root,KOG1374@2759|Eukaryota,2XE9F@2836|Bacillariophyta	2836|Bacillariophyta	Z	Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome	-	-	-	ko:K10389	ko05165,map05165	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	Tubulin,Tubulin_C
HKD1_k127_4233783_2	436308.Nmar_0230	6.736e-25	106.0	COG0526@1|root,arCOG01972@2157|Archaea,41T6S@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Thioredoxin	-	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_4233783_1	436308.Nmar_0232	2.13e-35	139.0	COG1371@1|root,arCOG04055@2157|Archaea,41SU0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Archease protein family (MTH1598/TM1083)	-	-	-	-	-	-	-	-	-	-	-	-	Archease
HKD1_k127_4233783_0	1229909.NSED_01090	3.079e-151	486.0	COG0124@1|root,arCOG00404@2157|Archaea,41S9T@651137|Thaumarchaeota	651137|Thaumarchaeota	J	histidyl-tRNA synthetase	-	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_4249839_0	1229909.NSED_04950	3.56e-74	253.0	COG1503@1|root,arCOG01742@2157|Archaea,41SEK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA	prf1	-	-	ko:K03265	ko03015,map03015	-	-	-	ko00000,ko00001,ko03012,ko03019	-	-	-	eRF1_1,eRF1_2,eRF1_3
HKD1_k127_4249839_3	340170.XP_007377104.1	3.097e-11	67.0	COG0526@1|root,KOG0191@2759|Eukaryota,38WBW@33154|Opisthokonta,3NYC8@4751|Fungi,3QQEF@4890|Ascomycota,3RTAN@4891|Saccharomycetes,479HG@766764|Debaryomycetaceae	4751|Fungi	O	OST3 / OST6 family, transporter family	-	GO:0000322,GO:0000323,GO:0000324,GO:0003674,GO:0003756,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005773,GO:0005783,GO:0005788,GO:0006457,GO:0006950,GO:0008150,GO:0008152,GO:0009987,GO:0012505,GO:0015035,GO:0015036,GO:0016491,GO:0016667,GO:0016671,GO:0016853,GO:0016860,GO:0016864,GO:0019153,GO:0031974,GO:0033554,GO:0034975,GO:0034976,GO:0043226,GO:0043227,GO:0043229,GO:0043231,GO:0043233,GO:0044422,GO:0044424,GO:0044432,GO:0044444,GO:0044446,GO:0044464,GO:0050896,GO:0051716,GO:0055114,GO:0070013,GO:0140096	5.3.4.1	ko:K09584	ko04141,map04141	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04131	-	-	-	Thioredoxin
HKD1_k127_4249839_2	436308.Nmar_0883	7.453e-47	172.0	COG0537@1|root,arCOG00419@2157|Archaea,41SNV@651137|Thaumarchaeota	651137|Thaumarchaeota	F	HIT domain	-	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_4249839_1	436308.Nmar_0884	6.165e-50	184.0	arCOG10557@1|root,arCOG10557@2157|Archaea,41T1I@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4298382_2	1229909.NSED_00515	6.551e-28	117.0	arCOG07810@1|root,arCOG07810@2157|Archaea,41T4X@651137|Thaumarchaeota	2157|Archaea	T	COG2114 Adenylate cyclase, family 3 (some proteins contain HAMP domain)	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc
HKD1_k127_4298382_0	1229909.NSED_02040	3.339e-86	293.0	COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD1_k127_4298382_1	1131266.ARWQ01000006_gene258	5.401e-58	205.0	COG1628@1|root,arCOG00928@2157|Archaea,41SMQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Protein of unknown function DUF99	-	-	-	ko:K09120	-	-	-	-	ko00000	-	-	-	DUF99
HKD1_k127_4303925_6	1229909.NSED_05215	2.238e-07	53.0	COG2522@1|root,arCOG00017@2157|Archaea,41SJZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transcriptional regulator	-	-	-	ko:K07108	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_4303925_2	1229909.NSED_05220	1.408e-87	299.0	COG0367@1|root,arCOG00071@2157|Archaea,41SMA@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
HKD1_k127_4303925_3	1131266.ARWQ01000002_gene493	2.587e-19	87.0	arCOG04508@1|root,arCOG04508@2157|Archaea,41SVW@651137|Thaumarchaeota	651137|Thaumarchaeota	P	YHS domain	-	-	-	-	-	-	-	-	-	-	-	-	YHS
HKD1_k127_4303925_4	203124.Tery_2706	2.413e-16	88.0	COG1357@1|root,COG1357@2|Bacteria,1G5I1@1117|Cyanobacteria,1HAQ1@1150|Oscillatoriales	1117|Cyanobacteria	S	Pentapeptide repeats (9 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Pentapeptide
HKD1_k127_4303925_0	436308.Nmar_1011	5.559e-114	375.0	COG0778@1|root,arCOG00288@2157|Archaea	2157|Archaea	C	Nitroreductase	-	-	1.5.1.39	ko:K19286	ko00740,ko01100,map00740,map01100	-	R05705,R05706	RC00126	ko00000,ko00001,ko01000	-	-	-	Nitroreductase
HKD1_k127_4303925_1	1229909.NSED_06640	4.318e-106	350.0	COG4742@1|root,arCOG04362@2157|Archaea,41SGE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD1_k127_4303925_5	1229909.NSED_03650	1.601e-10	67.0	arCOG08757@1|root,arCOG08757@2157|Archaea	1229909.NSED_03650|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4325164_1	1131266.ARWQ01000009_gene941	8.043e-59	209.0	COG1370@1|root,arCOG00991@2157|Archaea,41SP1@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Patch-forming domain C2 of tRNA-guanine transglycosylase	-	-	-	ko:K07398	-	-	-	-	ko00000	-	-	-	PUA,TGT_C2
HKD1_k127_4325164_3	1229909.NSED_08675	3.107e-45	166.0	COG1308@1|root,arCOG04061@2157|Archaea,41SNN@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Contacts the emerging nascent chain on the ribosome	nac	-	-	ko:K03626	-	-	-	-	ko00000	-	-	-	NAC
HKD1_k127_4325164_0	436308.Nmar_1600	2.204e-68	238.0	arCOG03142@1|root,arCOG03142@2157|Archaea,41T78@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4325164_2	1229909.NSED_08655	2.095e-46	171.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4325164_4	436308.Nmar_1598	8.06e-21	95.0	arCOG08790@1|root,arCOG08790@2157|Archaea,41SWN@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4372797_3	1229909.NSED_04775	8.957e-16	83.0	COG3353@1|root,arCOG01824@2157|Archaea	2157|Archaea	N	Archaeal flagellar protein F	flaF	-	-	ko:K07329	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Arch_flagellin
HKD1_k127_4372797_0	1229909.NSED_04760	4.804e-112	369.0	COG1378@1|root,arCOG02037@2157|Archaea,41T5N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	TrmB
HKD1_k127_4372797_1	1229909.NSED_04755	1.407e-94	317.0	COG0467@1|root,arCOG01171@2157|Archaea,41TA0@651137|Thaumarchaeota	651137|Thaumarchaeota	T	KaiC	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HKD1_k127_4395681_5	436308.Nmar_0325	1.757e-21	96.0	COG0099@1|root,arCOG01722@2157|Archaea,41SIW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rps13	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD1_k127_4395681_4	436308.Nmar_0324	5.104e-66	229.0	COG0522@1|root,arCOG04239@2157|Archaea,41SN3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rps4	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S4
HKD1_k127_4395681_0	436308.Nmar_0323	9.141e-271	844.0	COG0449@1|root,arCOG00057@2157|Archaea,41SFG@651137|Thaumarchaeota	651137|Thaumarchaeota	M	TIGRFAM glucosamine--fructose-6-phosphate aminotransferase (isomerizing)	-	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_4395681_1	1229909.NSED_01555	4.507e-126	412.0	COG2038@1|root,arCOG04272@2157|Archaea,41SD3@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the UPF0284 family	-	-	-	-	-	-	-	-	-	-	-	-	DBI_PRT
HKD1_k127_4395681_2	1229909.NSED_01550	2.736e-90	301.0	arCOG00517@1|root,arCOG00517@2157|Archaea,41SHJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_4395681_3	1131266.ARWQ01000001_gene1183	3.764e-85	289.0	COG0063@1|root,arCOG00018@2157|Archaea,41SHM@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX	nnrE	-	5.1.99.6	ko:K17759	-	-	-	-	ko00000,ko01000	-	-	-	YjeF_N
HKD1_k127_441166_3	43989.cce_0961	2.23e-14	83.0	2EHX5@1|root,33BNR@2|Bacteria,1GARZ@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_441166_4	436308.Nmar_1149	1.995e-11	74.0	arCOG10350@1|root,arCOG10350@2157|Archaea	2157|Archaea	C	sister chromatid segregation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_441166_0	436308.Nmar_1619	6.197e-24	108.0	COG0784@1|root,arCOG02391@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_441166_5	483218.BACPEC_00972	9.337e-10	66.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,24I1I@186801|Clostridia,269UM@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix ASNC type	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HKD1_k127_441166_2	1131266.ARWQ01000035_gene712	2.283e-21	95.0	COG1522@1|root,arCOG01117@2157|Archaea,41T6G@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_441166_1	1229909.NSED_01440	1.75e-21	94.0	COG0727@1|root,arCOG02579@2157|Archaea	2157|Archaea	S	Fe-S-cluster oxidoreductase	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_4411999_5	1229909.NSED_07225	2.939e-05	48.0	COG0517@1|root,arCOG00606@2157|Archaea	2157|Archaea	I	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_4411999_1	1229909.NSED_02475	2.022e-40	154.0	COG3174@1|root,arCOG04203@2157|Archaea	2157|Archaea	S	membrane	mgtC1	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	DUF4010,MgtC
HKD1_k127_4411999_3	1459636.NTE_01996	1.445e-21	99.0	COG0517@1|root,arCOG00606@2157|Archaea,41SRY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_4411999_2	436308.Nmar_0017	6.086e-24	103.0	arCOG08691@1|root,arCOG08691@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4411999_4	1385514.N782_13565	6.376e-12	71.0	COG0589@1|root,COG0589@2|Bacteria,1U42M@1239|Firmicutes,4I3ZW@91061|Bacilli,2YAUP@289201|Pontibacillus	91061|Bacilli	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_4411999_0	386456.JQKN01000008_gene1466	8.159e-78	267.0	COG0209@1|root,arCOG04276@2157|Archaea,2XUBW@28890|Euryarchaeota	28890|Euryarchaeota	F	Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and or for immediate growth after restoration of oxygen	nrdJ	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Intein_splicing,LAGLIDADG_3,Ribonuc_red_lgC,Ribonuc_red_lgN
HKD1_k127_4417927_0	1131266.ARWQ01000002_gene632	1.65e-159	507.0	COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota	2157|Archaea	O	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384,ko:K03387	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD1_k127_4417927_1	1459636.NTE_01164	1.316e-71	250.0	arCOG00144@1|root,arCOG11894@1|root,arCOG00144@2157|Archaea,arCOG11894@2157|Archaea	2157|Archaea	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4421867_0	1229909.NSED_09440	2.755e-84	283.0	COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_4421867_3	632245.CLP_1058	2.855e-05	51.0	COG0347@1|root,COG0347@2|Bacteria,1VASB@1239|Firmicutes,24J84@186801|Clostridia,36JNI@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the P(II) protein family	-	-	-	ko:K02589	-	-	-	-	ko00000	-	-	-	P-II
HKD1_k127_4421867_2	1229909.NSED_09445	1.046e-33	132.0	COG0347@1|root,arCOG02305@2157|Archaea	2157|Archaea	K	Belongs to the P(II) protein family	-	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	DUF2226,P-II
HKD1_k127_4421867_1	1094980.Mpsy_2342	4.209e-34	147.0	COG0467@1|root,arCOG01178@2157|Archaea,2Y0GM@28890|Euryarchaeota	28890|Euryarchaeota	T	PFAM GvpD gas vesicle	gvpD	-	-	-	-	-	-	-	-	-	-	-	GvpD
HKD1_k127_454710_1	1229909.NSED_06590	9.125e-82	285.0	arCOG08686@1|root,arCOG08686@2157|Archaea,41T56@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_454710_0	436308.Nmar_1180	3.042e-89	296.0	COG1945@1|root,arCOG04490@2157|Archaea,41SPZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the PdaD family	pdaD	-	4.1.1.19	ko:K02626	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PvlArgDC
HKD1_k127_454710_2	1131266.ARWQ01000014_gene95	6.149e-57	201.0	COG1225@1|root,arCOG00310@2157|Archaea	2157|Archaea	O	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD1_k127_454710_3	1229909.NSED_06555	1.123e-34	134.0	COG0221@1|root,arCOG01711@2157|Archaea,41T3F@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD1_k127_4554176_0	436308.Nmar_1539	3.612e-140	451.0	COG1236@1|root,arCOG00541@2157|Archaea,41SAJ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B_6,RMMBL
HKD1_k127_4554176_1	436308.Nmar_1540	5.668e-93	313.0	COG0122@1|root,arCOG00464@2157|Archaea,41SHE@651137|Thaumarchaeota	651137|Thaumarchaeota	L	8-oxoguanine DNA glycosylase	-	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_4554176_2	1229909.NSED_08470	4.239e-37	142.0	arCOG08633@1|root,arCOG08633@2157|Archaea,41SUK@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4557896_0	1230343.CANP01000039_gene2895	7.168e-124	401.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,1RN4D@1236|Gammaproteobacteria,1JD2W@118969|Legionellales	118969|Legionellales	C	Zinc-binding dehydrogenase	yahK	-	-	ko:K13979	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_4557896_2	436308.Nmar_0199	7.058e-28	114.0	arCOG10519@1|root,arCOG10519@2157|Archaea,41T6D@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4557896_3	1229909.NSED_06150	2.603e-27	118.0	COG1430@1|root,arCOG03116@2157|Archaea,41SP3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD1_k127_4557896_1	1131266.ARWQ01000002_gene644	1.424e-38	145.0	COG1250@1|root,arCOG00249@2157|Archaea,41S92@651137|Thaumarchaeota	651137|Thaumarchaeota	I	3-hydroxyacyl-CoA dehydrogenase	-	-	1.1.1.35,4.2.1.17	ko:K15016	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00374,M00375	R01975,R03026	RC00117,RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_4563084_0	1459636.NTE_02229	1.266e-185	595.0	COG1239@1|root,arCOG00438@2157|Archaea	2157|Archaea	H	magnesium chelatase	-	-	6.6.1.1	ko:K03405	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R03877	RC01012	ko00000,ko00001,ko01000	-	-	-	AAA_5
HKD1_k127_4563084_1	1459636.NTE_02230	6.773e-141	460.0	COG2304@1|root,arCOG02900@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K07114	-	-	-	-	ko00000,ko02000	1.A.13.2.2,1.A.13.2.3	-	-	VWA,VWA_2
HKD1_k127_4563084_2	1229909.NSED_01575	2.035e-18	88.0	arCOG08780@1|root,arCOG08780@2157|Archaea,41T84@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4568500_3	436308.Nmar_0440	1.311e-17	83.0	COG0061@1|root,arCOG01348@2157|Archaea,41SHP@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	-	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD1_k127_4568500_0	1229909.NSED_02285	3.498e-154	490.0	COG2897@1|root,arCOG02019@2157|Archaea,41SZQ@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_4568500_2	1459636.NTE_01353	1.422e-36	140.0	arCOG08760@1|root,arCOG08760@2157|Archaea,41T7P@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4568500_1	1229909.NSED_02295	1.172e-62	218.0	COG1146@1|root,arCOG04548@2157|Archaea,41SH5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_4591584_1	1131266.ARWQ01000001_gene1170	1.38e-157	506.0	COG1641@1|root,arCOG02701@2157|Archaea,41SDC@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function DUF111	-	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_4591584_2	1229909.NSED_01635	1.149e-99	331.0	COG1606@1|root,arCOG00043@2157|Archaea,41SF3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	tRNA methyl transferase	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	QueC
HKD1_k127_4591584_0	1229909.NSED_01640	3.941e-173	550.0	COG1104@1|root,arCOG00066@2157|Archaea,41SB1@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine desulfurase	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_4591584_3	1229909.NSED_01600	5.087e-09	64.0	arCOG08778@1|root,arCOG08778@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4619888_1	436308.Nmar_1581	1.16e-51	188.0	COG2266@1|root,arCOG01871@2157|Archaea,41SRI@651137|Thaumarchaeota	651137|Thaumarchaeota	M	MobA-like NTP transferase domain	-	-	2.7.7.62	ko:K19712	ko00860,ko01100,map00860,map01100	-	R05222	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_4619888_3	768679.TTX_0576	1.309e-10	65.0	COG2051@1|root,arCOG04108@2157|Archaea,2XR0Y@28889|Crenarchaeota	28889|Crenarchaeota	J	PFAM ribosomal protein	rps27e	GO:0000028,GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0006996,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015935,GO:0016043,GO:0019538,GO:0022607,GO:0022613,GO:0022618,GO:0022626,GO:0022627,GO:0032991,GO:0034622,GO:0034641,GO:0034645,GO:0042254,GO:0042255,GO:0042274,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0065003,GO:0070925,GO:0071704,GO:0071826,GO:0071840,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02978	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S27e
HKD1_k127_4619888_2	1229909.NSED_00610	2.122e-38	145.0	COG1631@1|root,arCOG04109@2157|Archaea,41SQZ@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl44e	-	-	ko:K02929	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L44
HKD1_k127_4619888_0	1131266.ARWQ01000009_gene962	5.239e-106	348.0	COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HKD1_k127_4622618_1	621372.ACIH01000067_gene3007	1.797e-10	64.0	COG1937@1|root,COG1937@2|Bacteria,1VFB9@1239|Firmicutes,4HNVQ@91061|Bacilli,26Z7E@186822|Paenibacillaceae	91061|Bacilli	S	Metal-sensitive transcriptional repressor	csoR_1	-	-	-	-	-	-	-	-	-	-	-	Trns_repr_metal
HKD1_k127_4622618_0	105420.BBPO01000027_gene6925	1.005e-14	82.0	2DPF3@1|root,331TJ@2|Bacteria,2IK5R@201174|Actinobacteria,2NKS8@228398|Streptacidiphilus	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4634920_2	1459636.NTE_01615	5.074e-39	148.0	arCOG08751@1|root,arCOG08751@2157|Archaea,41SS7@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4634920_3	1131266.ARWQ01000002_gene624	6.226e-38	144.0	arCOG08750@1|root,arCOG08750@2157|Archaea,41SSB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4634920_0	1229909.NSED_03690	1.641e-55	197.0	COG1310@1|root,arCOG01139@2157|Archaea,41SQ7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	metal-dependent protease of the PAD1 JAB1 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Prok-JAB
HKD1_k127_4634920_1	436308.Nmar_0714	1.602e-54	203.0	arCOG00373@1|root,arCOG00373@2157|Archaea,41ST8@651137|Thaumarchaeota	651137|Thaumarchaeota	L	ATPase involved in DNA repair	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4665092_0	1229909.NSED_08245	5.641e-62	214.0	arCOG08677@1|root,arCOG08677@2157|Archaea,41SVJ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4665092_1	1229909.NSED_04820	2.157e-50	196.0	COG0642@1|root,arCOG02362@1|root,arCOG02358@2157|Archaea,arCOG02362@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,PAS_3,PAS_4,PAS_8,PAS_9,Response_reg,dCache_1,sCache_3_3
HKD1_k127_4716982_0	1459636.NTE_02293	4.014e-67	234.0	COG1855@1|root,arCOG04116@2157|Archaea,41SX0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Large family of predicted nucleotide-binding domains	-	-	-	ko:K06865	-	-	-	-	ko00000	-	-	-	KH_1,T2SSE
HKD1_k127_4716982_2	1459636.NTE_00257	4.145e-21	104.0	arCOG06883@1|root,arCOG06883@2157|Archaea,41TAV@651137|Thaumarchaeota	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2334,DZR
HKD1_k127_4716982_1	1229909.NSED_06170	2.47e-34	135.0	COG0784@1|root,arCOG02391@2157|Archaea,41TB0@651137|Thaumarchaeota	651137|Thaumarchaeota	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_4780916_1	1229909.NSED_06330	7.144e-141	451.0	COG0505@1|root,arCOG00064@2157|Archaea,41SF0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	carbamoyl-phosphate synthase, small subunit	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_4780916_2	436308.Nmar_1085	3.899e-06	48.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_4780916_0	436308.Nmar_1085	2.314e-311	962.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_4785959_4	436308.Nmar_0833	6.889e-18	83.0	COG0498@1|root,arCOG01434@2157|Archaea,41S5N@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4785959_1	1131266.ARWQ01000002_gene548	1.44e-151	489.0	COG1253@1|root,arCOG00626@2157|Archaea,41T1G@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Transporter associated domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_4785959_0	1131266.ARWQ01000002_gene549	1.1e-159	509.0	COG0057@1|root,arCOG00493@2157|Archaea,41SDF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	-	-	1.2.1.59	ko:K00150	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166	R01061,R01063	RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD1_k127_4785959_3	436308.Nmar_0829	3.164e-69	242.0	COG1651@1|root,arCOG02868@2157|Archaea,41T2A@651137|Thaumarchaeota	651137|Thaumarchaeota	O	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD1_k127_4785959_2	1131266.ARWQ01000002_gene551	4.243e-83	278.0	COG3425@1|root,arCOG01767@2157|Archaea,41SAQ@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Hydroxymethylglutaryl-coenzyme A synthase N terminal	-	-	2.3.3.10	ko:K01641	ko00072,ko00280,ko00650,ko00900,ko01100,ko01110,ko01130,map00072,map00280,map00650,map00900,map01100,map01110,map01130	M00088,M00095	R01978	RC00004,RC00503	ko00000,ko00001,ko00002,ko01000	-	-	-	HMG_CoA_synt_C,HMG_CoA_synt_N
HKD1_k127_4820568_2	1131266.ARWQ01000001_gene1173	3.956e-98	325.0	COG1814@1|root,arCOG01096@2157|Archaea,41T13@651137|Thaumarchaeota	651137|Thaumarchaeota	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_4820568_1	436308.Nmar_0337	3.743e-105	347.0	COG1691@1|root,arCOG02465@2157|Archaea,41SCY@651137|Thaumarchaeota	651137|Thaumarchaeota	S	AIR carboxylase	-	-	-	ko:K06898	-	-	-	-	ko00000	-	-	-	AIRC
HKD1_k127_4820568_0	436308.Nmar_0338	6.226e-157	499.0	COG0039@1|root,arCOG00246@2157|Archaea,41S7Z@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the LDH MDH superfamily	-	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD1_k127_4829352_0	1229909.NSED_01120	1.93e-198	625.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
HKD1_k127_4829352_1	1131266.ARWQ01000008_gene299	6.242e-50	182.0	arCOG00552@1|root,arCOG00552@2157|Archaea,41SRW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	GINS complex protein	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	Sld5
HKD1_k127_4839793_4	436308.Nmar_1704	4.257e-23	102.0	arCOG08775@1|root,arCOG08775@2157|Archaea,41T9K@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4839793_5	436308.Nmar_1703	3.943e-15	83.0	arCOG03788@1|root,arCOG03788@2157|Archaea,41T96@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4839793_1	436308.Nmar_1699	2.956e-59	212.0	arCOG08770@1|root,arCOG08770@2157|Archaea,41T2S@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4839793_0	1229909.NSED_09030	1.333e-110	362.0	COG2897@1|root,arCOG02019@2157|Archaea,41SXR@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rhodanese Homology Domain	-	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD1_k127_4839793_2	263820.PTO0494	5.31e-27	113.0	COG0636@1|root,arCOG02455@2157|Archaea,2Y1B9@28890|Euryarchaeota,242DV@183967|Thermoplasmata	183967|Thermoplasmata	C	ATP synthase subunit C	-	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD1_k127_4839793_6	273116.14324262	2.955e-11	71.0	COG1390@1|root,arCOG00869@2157|Archaea,2Y7CD@28890|Euryarchaeota,242HT@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	-
HKD1_k127_4839793_3	273075.Ta0002	2.925e-23	105.0	COG1527@1|root,arCOG02459@2157|Archaea,2Y67I@28890|Euryarchaeota,24275@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD1_k127_4892342_1	1229909.NSED_09440	1.666e-68	235.0	COG0004@1|root,arCOG04397@2157|Archaea,41SZ0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_4892342_2	1229909.NSED_04365	1.032e-34	137.0	arCOG00516@1|root,arCOG00516@2157|Archaea,41SS2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD1_k127_4892342_0	1459636.NTE_00742	5.261e-73	251.0	COG0778@1|root,arCOG00288@2157|Archaea	2157|Archaea	C	Nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4892342_3	1459636.NTE_02416	1.419e-18	88.0	COG0671@1|root,arCOG03056@2157|Archaea	2157|Archaea	I	PFAM phosphoesterase, PA-phosphatase related	sepP	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_4897403_3	1131266.ARWQ01000001_gene1208	1.068e-50	182.0	COG0343@1|root,arCOG00989@2157|Archaea,41SF4@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs	tgtA	-	2.4.2.48	ko:K18779	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_4897403_4	1131266.ARWQ01000001_gene1207	6.132e-48	177.0	COG1936@1|root,arCOG01038@2157|Archaea,41SPH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates	-	-	2.7.4.3	ko:K18532	ko00230,ko01100,ko01110,ko01130,ko03008,map00230,map01100,map01110,map01130,map03008	M00049	R00127,R01547	RC00002	ko00000,ko00001,ko00002,ko01000,ko03009	-	-	-	AAA_18
HKD1_k127_4897403_0	1131266.ARWQ01000001_gene1206	1.986e-172	548.0	COG0012@1|root,arCOG00357@2157|Archaea,41S71@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
HKD1_k127_4897403_1	1131266.ARWQ01000001_gene1205	4.023e-169	535.0	COG0533@1|root,arCOG01183@2157|Archaea,41SDX@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37	kae1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_4897403_5	436308.Nmar_1532	1.14e-31	127.0	arCOG10590@1|root,arCOG10590@2157|Archaea,41SSG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4897403_2	1131266.ARWQ01000001_gene1202	1.265e-75	258.0	COG0533@1|root,arCOG01185@2157|Archaea,41SJJ@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Mn2 -dependent serine threonine protein kinase	-	-	2.7.11.1	ko:K08851	-	-	-	-	ko00000,ko01000,ko01001,ko03016	-	-	-	Pkinase
HKD1_k127_4897403_6	633148.Tagg_1368	2.021e-20	93.0	COG0127@1|root,arCOG04184@2157|Archaea,2XQHP@28889|Crenarchaeota	28889|Crenarchaeota	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	ntpA	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_4913237_6	1459636.NTE_01087	1.571e-61	213.0	COG1032@1|root,arCOG01357@2157|Archaea,41SCX@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_4913237_2	1131266.ARWQ01000004_gene1493	7.105e-117	381.0	COG0543@1|root,arCOG02199@2157|Archaea,41SY5@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B	-	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	-	DHODB_Fe-S_bind,NAD_binding_1
HKD1_k127_4913237_1	436308.Nmar_1390	1.342e-145	466.0	COG0167@1|root,arCOG00603@2157|Archaea	2157|Archaea	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	GO:0003674,GO:0003824,GO:0004152,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006206,GO:0006207,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009112,GO:0009987,GO:0016491,GO:0016627,GO:0016635,GO:0018130,GO:0019856,GO:0034641,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046112,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072527,GO:0072528,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	1.3.1.1,1.3.1.14,1.3.5.2,1.3.98.1	ko:K00226,ko:K00254,ko:K17723,ko:K17828	ko00240,ko00410,ko00770,ko01100,map00240,map00410,map00770,map01100	M00046,M00051	R00977,R01414,R01867,R01868,R01869,R11026	RC00051,RC00072,RC00123	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_4913237_0	436308.Nmar_1391	2.277e-158	510.0	COG1498@1|root,arCOG01923@2157|Archaea,41SY9@651137|Thaumarchaeota	651137|Thaumarchaeota	J	NOSIC (NUC001) domain	-	-	-	ko:K14564	ko03008,map03008	-	-	-	ko00000,ko00001,ko03009	-	-	-	Nop
HKD1_k127_4913237_3	436308.Nmar_1392	3.83e-95	319.0	COG0513@1|root,arCOG00078@2157|Archaea,41SM2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA	flpA	-	-	ko:K04795	-	-	-	-	ko00000,ko03009	-	-	-	Fibrillarin
HKD1_k127_4913237_4	436308.Nmar_1393	5.217e-79	269.0	COG0164@1|root,arCOG04121@2157|Archaea,41SK9@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_4913237_5	436308.Nmar_1394	1.678e-77	264.0	COG1867@1|root,arCOG01219@2157|Archaea,41SAG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family	-	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
HKD1_k127_4962388_1	1229909.NSED_02035	6.963e-08	55.0	arCOG11430@1|root,arCOG11430@2157|Archaea	1229909.NSED_02035|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4962388_0	1459636.NTE_00627	1.718e-196	620.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Pyridoxal-phosphate dependent enzyme	-	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4969370_0	1459636.NTE_03060	1.019e-138	449.0	COG1131@1|root,arCOG00196@2157|Archaea,41S73@651137|Thaumarchaeota	651137|Thaumarchaeota	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran,DUF4162
HKD1_k127_4969370_1	1459636.NTE_03061	9.73e-106	349.0	COG0842@1|root,arCOG01467@2157|Archaea,41SQQ@651137|Thaumarchaeota	651137|Thaumarchaeota	V	PFAM ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_4969370_2	204669.Acid345_3583	3.73e-30	128.0	COG3391@1|root,COG3391@2|Bacteria,3Y7M7@57723|Acidobacteria,2JP55@204432|Acidobacteriia	2|Bacteria	S	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	He_PIG,Lactonase,VCBS
HKD1_k127_4984512_2	215803.DB30_7621	7.25e-07	55.0	COG0747@1|root,COG5492@1|root,COG0747@2|Bacteria,COG5492@2|Bacteria,1QX9G@1224|Proteobacteria,43C2P@68525|delta/epsilon subdivisions,2X7D9@28221|Deltaproteobacteria,2Z3FQ@29|Myxococcales	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36,REJ
HKD1_k127_4984512_0	436308.Nmar_1040	3.8e-16	92.0	COG3794@1|root,arCOG05978@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea	2157|Archaea	C	Fibronectin type III domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,ThuA,fn3
HKD1_k127_4984512_1	1229909.NSED_00340	4.033e-16	84.0	arCOG08796@1|root,arCOG08796@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4989420_0	436308.Nmar_0242	2.276e-225	703.0	COG1241@1|root,arCOG00439@2157|Archaea,41SA7@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the MCM family	-	-	-	ko:K10726	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	MCM,MCM_N,MCM_OB
HKD1_k127_4989420_1	436308.Nmar_0243	4.565e-37	141.0	COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
HKD1_k127_5003076_3	436308.Nmar_1661	1.718e-08	57.0	COG1733@1|root,arCOG01057@2157|Archaea,41T7C@651137|Thaumarchaeota	651137|Thaumarchaeota	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_5003076_1	398512.JQKC01000034_gene4931	7.047e-39	156.0	COG2333@1|root,COG2333@2|Bacteria	2|Bacteria	N	competence protein COMEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	CW_binding_1,Lactamase_B
HKD1_k127_5003076_2	1229909.NSED_05360	1.799e-26	112.0	COG0784@1|root,arCOG02391@2157|Archaea,41T9J@651137|Thaumarchaeota	2157|Archaea	T	COG0784 FOG CheY-like receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_5003076_4	436308.Nmar_0707	6.696e-06	52.0	COG2201@1|root,arCOG02382@2157|Archaea	2157|Archaea	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD1_k127_5003076_0	485913.Krac_11202	7.4e-168	540.0	COG3670@1|root,COG3670@2|Bacteria	2|Bacteria	Q	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	-	-	-	ko:K11159	-	-	-	-	ko00000	-	-	-	RPE65
HKD1_k127_5048568_2	1459636.NTE_02998	6.561e-26	111.0	COG0685@1|root,arCOG00475@2157|Archaea,41SNK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	cytochrome-c peroxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5048568_0	436308.Nmar_1268	2.573e-164	521.0	COG0646@1|root,arCOG08715@2157|Archaea,41SWZ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	homocysteine S-methyltransferase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HKD1_k127_5048568_1	1459636.NTE_02986	4.21e-77	260.0	COG0294@1|root,COG1410@1|root,arCOG01978@2157|Archaea,arCOG02029@2157|Archaea,41SXT@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
HKD1_k127_5055408_2	1229909.NSED_06830	2.299e-128	422.0	COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota	651137|Thaumarchaeota	V	antibiotic catabolic process	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HKD1_k127_5055408_1	436308.Nmar_1198	9.279e-153	492.0	COG0585@1|root,arCOG04252@2157|Archaea,41S7C@651137|Thaumarchaeota	651137|Thaumarchaeota	J	tRNA pseudouridine synthase	-	-	5.4.99.27	ko:K06176	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruD
HKD1_k127_5055408_9	1229909.NSED_06960	1.089e-08	63.0	arCOG08716@1|root,arCOG08716@2157|Archaea	1229909.NSED_06960|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5055408_0	1459636.NTE_01327	3.071e-176	565.0	arCOG03561@1|root,arCOG03562@1|root,arCOG03561@2157|Archaea,arCOG03562@2157|Archaea	2157|Archaea	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	NHL,Tail_P2_I,Thioredoxin_8
HKD1_k127_5055408_6	273057.SSO5522	2.569e-12	69.0	COG1522@1|root,arCOG01117@2157|Archaea,2XR1K@28889|Crenarchaeota	28889|Crenarchaeota	K	PFAM regulatory protein AsnC Lrp family	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_5055408_3	436308.Nmar_1196	6.496e-75	258.0	arCOG08694@1|root,arCOG08694@2157|Archaea,41SZ1@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5055408_7	1229909.NSED_07025	1.638e-09	65.0	arCOG08768@1|root,arCOG08768@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5055408_4	1131266.ARWQ01000004_gene1433	6.622e-64	222.0	COG1632@1|root,arCOG04209@2157|Archaea,41SND@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein L15E	-	-	-	ko:K02877	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L15e
HKD1_k127_5055408_5	436308.Nmar_0333	4.967e-16	86.0	arCOG08778@1|root,arCOG08778@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5055408_10	436308.Nmar_1257	2.155e-07	61.0	arCOG08033@1|root,arCOG08033@2157|Archaea	2157|Archaea	C	copper ion binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5107271_0	1131266.ARWQ01000001_gene1266	1.513e-128	417.0	COG1201@1|root,arCOG00557@2157|Archaea,41S8P@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD/H associated	-	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD1_k127_5107271_2	1131266.ARWQ01000001_gene1267	8.827e-51	187.0	COG0468@1|root,arCOG00417@2157|Archaea,41SQC@651137|Thaumarchaeota	651137|Thaumarchaeota	T	RecA RadA	-	-	-	ko:K04482,ko:K04483	ko03440,ko03460,ko05200,ko05212,map03440,map03460,map05200,map05212	-	-	-	ko00000,ko00001,ko03400,ko04121,ko04131	-	-	-	Rad51
HKD1_k127_5107271_3	1229909.NSED_00125	2.731e-34	132.0	COG1958@1|root,arCOG00998@2157|Archaea,41SS5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	snRNP Sm proteins	-	-	-	ko:K04796	-	-	-	-	ko00000	-	-	-	LSM
HKD1_k127_5107271_1	1459636.NTE_01726	3.191e-106	348.0	COG0192@1|root,arCOG07444@2157|Archaea,41S5P@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosylmethionine synthetase	-	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_5133838_1	1131266.ARWQ01000018_gene769	4.221e-38	147.0	COG0009@1|root,arCOG01952@2157|Archaea,41SPF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Sua5 YciO YrdC YwlC family	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	Sua5_yciO_yrdC
HKD1_k127_5133838_2	436308.Nmar_1426	1.285e-33	131.0	COG3432@1|root,arCOG01055@2157|Archaea,41SUJ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
HKD1_k127_5133838_0	1229909.NSED_07815	1.28e-77	264.0	arCOG08771@1|root,arCOG08771@2157|Archaea,41SNZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5136103_2	1229909.NSED_09130	1.122e-49	181.0	COG1522@1|root,arCOG01586@2157|Archaea,41T3N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_24
HKD1_k127_5136103_1	436308.Nmar_1716	5.724e-71	243.0	COG0494@1|root,arCOG01073@2157|Archaea,41T73@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_5136103_0	436308.Nmar_1717	6.919e-116	381.0	COG0704@1|root,arCOG00318@2157|Archaea,41T1H@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	PhoU
HKD1_k127_5136103_3	1229909.NSED_09150	6.112e-39	149.0	COG1829@1|root,arCOG04263@2157|Archaea,41T1V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	kinase, sugar kinase superfamily	-	-	2.7.1.169	ko:K06982	ko00770,ko01100,map00770,map01100	-	R09378	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	GHMP_kinases_N
HKD1_k127_5137598_3	436308.Nmar_0501	2.844e-13	74.0	COG0671@1|root,arCOG03056@2157|Archaea,41SQ8@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD1_k127_5137598_0	436308.Nmar_0500	1.433e-199	627.0	COG0126@1|root,arCOG00496@2157|Archaea,41SMB@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate kinase	pgk	-	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_5137598_1	1131266.ARWQ01000005_gene813	6.97e-27	113.0	arCOG08758@1|root,arCOG08758@2157|Archaea,41SVS@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5137598_2	1229909.NSED_02500	7.144e-14	72.0	COG0822@1|root,arCOG02077@2157|Archaea,41SPT@651137|Thaumarchaeota	651137|Thaumarchaeota	C	SUF system FeS assembly protein	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_5143451_1	1459636.NTE_01163	8.042e-155	493.0	COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5143451_8	436308.Nmar_0305	2.608e-42	158.0	arCOG08781@1|root,arCOG08781@2157|Archaea,41SVY@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5143451_5	1229909.NSED_01475	2.731e-99	330.0	COG0500@1|root,arCOG01631@2157|Archaea,41SJC@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	RNA methylase	-	-	-	-	-	-	-	-	-	-	-	-	DOT1
HKD1_k127_5143451_10	1131266.ARWQ01000001_gene1195	4.223e-27	112.0	COG1698@1|root,arCOG04308@2157|Archaea,41SRP@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the UPF0147 family	-	-	-	ko:K09721	-	-	-	-	ko00000	-	-	-	UPF0147
HKD1_k127_5143451_9	436308.Nmar_0308	6.963e-42	156.0	COG2146@1|root,arCOG02852@2157|Archaea,41SSE@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rieske 2Fe-2S	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD1_k127_5143451_2	1229909.NSED_01495	3.74e-134	434.0	COG0179@1|root,arCOG00235@2157|Archaea,41S5K@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	2-keto-4-pentenoate hydratase 2-oxohepta-3-ene-1,7-dioic acid hydratase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_5143451_0	1131266.ARWQ01000001_gene1192	4.927e-242	759.0	COG0008@1|root,arCOG04302@2157|Archaea,41S5V@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD1_k127_5143451_3	436308.Nmar_0312	6.355e-127	414.0	COG0142@1|root,arCOG01726@2157|Archaea,41SEV@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13787	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00365	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_5143451_6	436308.Nmar_0313	4.459e-89	297.0	COG1443@1|root,arCOG01081@2157|Archaea,41T09@651137|Thaumarchaeota	651137|Thaumarchaeota	I	NUDIX domain	-	-	5.3.3.2	ko:K01823	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00095,M00096,M00364,M00365,M00366,M00367	R01123	RC00455	ko00000,ko00001,ko00002,ko01000	-	-	-	NUDIX
HKD1_k127_5143451_4	436308.Nmar_0314	5.053e-103	341.0	COG1608@1|root,arCOG00860@2157|Archaea,41SI4@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Amino acid kinase family	-	-	2.7.4.26	ko:K06981	ko00900,ko01110,ko01130,map00900,map01110,map01130	-	R10093	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_5143451_7	1229909.NSED_01520	1.457e-88	302.0	COG1577@1|root,arCOG01028@2157|Archaea,41SKC@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids	mvk	-	2.7.1.36	ko:K00869	ko00900,ko01100,ko01110,ko01130,ko04146,map00900,map01100,map01110,map01130,map04146	M00095	R02245	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_5191623_2	1229909.NSED_05675	2.954e-43	164.0	COG1846@1|root,arCOG03748@2157|Archaea,41T7R@651137|Thaumarchaeota	651137|Thaumarchaeota	K	DNA-binding transcription factor activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5191623_1	436308.Nmar_0982	9.131e-59	206.0	COG1832@1|root,arCOG04227@2157|Archaea,41SMT@651137|Thaumarchaeota	651137|Thaumarchaeota	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD1_k127_5191623_3	436308.Nmar_0981	4.138e-26	111.0	arCOG05491@1|root,arCOG05491@2157|Archaea,41SVB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5191623_0	1229909.NSED_05660	1.206e-85	286.0	COG0012@1|root,arCOG00357@2157|Archaea,41S8X@651137|Thaumarchaeota	651137|Thaumarchaeota	J	GTPase of unknown function C-terminal	-	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,MMR_HSR1_C,TGS
HKD1_k127_5208059_1	436308.Nmar_0734	5.71e-68	238.0	COG0277@1|root,arCOG00337@2157|Archaea,41T0E@651137|Thaumarchaeota	651137|Thaumarchaeota	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_5208059_0	1131266.ARWQ01000006_gene236	3.375e-152	489.0	COG4046@1|root,arCOG04181@2157|Archaea,41S8T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF1512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1512
HKD1_k127_5208059_3	1131266.ARWQ01000006_gene237	1.833e-14	75.0	arCOG03770@1|root,arCOG03770@2157|Archaea,41TAR@651137|Thaumarchaeota	651137|Thaumarchaeota	M	metalloendopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5208059_2	1229909.NSED_01075	1.672e-58	206.0	COG0667@1|root,arCOG01617@2157|Archaea,41SXK@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_5214498_1	1459636.NTE_01932	2.816e-23	105.0	COG2133@1|root,arCOG02796@2157|Archaea	1459636.NTE_01932|-	G	COG2133 Glucose sorbosone dehydrogenases	-	-	-	ko:K21430	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_5214498_2	1229909.NSED_06670	1.624e-17	87.0	arCOG08757@1|root,arCOG08757@2157|Archaea	1229909.NSED_06670|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5214498_0	1459636.NTE_03333	7.987e-42	163.0	COG1733@1|root,arCOG01057@2157|Archaea	2157|Archaea	K	Transcriptional regulator	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	-
HKD1_k127_5214498_3	1229909.NSED_08655	2.519e-10	65.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5248656_1	436308.Nmar_0031	6.098e-37	146.0	arCOG10512@1|root,arCOG10512@2157|Archaea,41T3J@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5248656_2	273057.SSO2746	3.222e-23	113.0	COG0477@1|root,arCOG00130@2157|Archaea,2XSS5@28889|Crenarchaeota	28889|Crenarchaeota	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_5248656_0	1131266.ARWQ01000001_gene1340	7.562e-75	257.0	COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5260610_2	266762.HQ36_01010	1.948e-12	70.0	COG0127@1|root,COG0127@2|Bacteria,4NM42@976|Bacteroidetes,2FP46@200643|Bacteroidia,22XN1@171551|Porphyromonadaceae	976|Bacteroidetes	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009058,GO:0009141,GO:0009143,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0018130,GO:0019438,GO:0019439,GO:0019637,GO:0034404,GO:0034641,GO:0034654,GO:0034655,GO:0044237,GO:0044238,GO:0044248,GO:0044249,GO:0044270,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046434,GO:0046483,GO:0046700,GO:0047429,GO:0055086,GO:0071704,GO:1901292,GO:1901360,GO:1901361,GO:1901362,GO:1901575,GO:1901576	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_5260610_1	436308.Nmar_1529	7.212e-147	470.0	COG0731@1|root,arCOG04174@2157|Archaea,41SBS@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe)	taw1	-	4.1.3.44	ko:K15449	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,Wyosine_form
HKD1_k127_5260610_0	1459636.NTE_01163	7.893e-149	478.0	COG1064@1|root,arCOG01455@2157|Archaea,41SA9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_5264400_3	436308.Nmar_0785	6.972e-24	104.0	COG0640@1|root,arCOG01687@2157|Archaea,41ST3@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD1_k127_5264400_2	1131266.ARWQ01000002_gene580	1.938e-49	179.0	COG2090@1|root,arCOG04171@2157|Archaea,41SNF@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF371)	-	-	-	ko:K09738	-	-	-	-	ko00000	-	-	-	DUF371
HKD1_k127_5264400_0	1459636.NTE_01839	1.972e-114	374.0	COG0638@1|root,arCOG00971@2157|Archaea,41SYA@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Proteasome endopeptidase complex	-	-	3.4.25.1	ko:K03432	ko03050,map03050	M00342,M00343	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03051	-	-	-	Proteasome,Proteasome_A_N
HKD1_k127_5264400_1	1229909.NSED_04490	3.349e-53	192.0	COG2106@1|root,arCOG04069@2157|Archaea,41SI7@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative RNA methyltransferase	-	-	-	ko:K09142	-	-	-	-	ko00000	-	-	-	Methyltrn_RNA_3
HKD1_k127_5265143_3	1131266.ARWQ01000003_gene1507	5.653e-17	87.0	arCOG08825@1|root,arCOG08825@2157|Archaea,41T4G@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5265143_2	1459636.NTE_01652	8.434e-28	129.0	COG4257@1|root,arCOG03564@2157|Archaea,41SM7@651137|Thaumarchaeota	651137|Thaumarchaeota	V	antibiotic catabolic process	-	-	-	ko:K18235	-	-	-	-	ko00000,ko01000,ko01504	-	-	-	-
HKD1_k127_5265143_1	1229909.NSED_08350	2.592e-93	308.0	COG2101@1|root,arCOG01764@2157|Archaea,41SZD@651137|Thaumarchaeota	651137|Thaumarchaeota	K	General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation	-	-	-	ko:K03120	ko03022,ko05016,ko05165,ko05166,ko05168,ko05169,ko05203,map03022,map05016,map05165,map05166,map05168,map05169,map05203	-	-	-	ko00000,ko00001,ko03000,ko03021	-	-	-	TBP
HKD1_k127_5265143_0	933801.Ahos_0953	5.293e-172	552.0	COG0591@1|root,arCOG01316@2157|Archaea,2XR75@28889|Crenarchaeota	28889|Crenarchaeota	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD1_k127_5265143_4	1095769.CAHF01000005_gene1548	3.943e-07	54.0	2EGF3@1|root,33A73@2|Bacteria,1N9KR@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3311)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3311
HKD1_k127_5305124_3	1229909.NSED_01910	1.809e-14	76.0	COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_5305124_0	436308.Nmar_0397	7.176e-131	424.0	COG0448@1|root,arCOG00912@2157|Archaea,41SEY@651137|Thaumarchaeota	651137|Thaumarchaeota	E	aspartate ornithine carbamoyltransferase carbamoyl-P binding domain	-	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_5305124_2	1229909.NSED_01925	1.031e-70	243.0	COG0256@1|root,arCOG04088@2157|Archaea,41SQW@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rpl18	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5e
HKD1_k127_5305124_1	1229909.NSED_01930	4.225e-95	315.0	COG0098@1|root,arCOG04087@2157|Archaea,41SFS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the universal ribosomal protein uS5 family	-	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD1_k127_5325883_0	1229909.NSED_07580	2.569e-138	446.0	COG3593@1|root,arCOG03235@2157|Archaea,41SZV@651137|Thaumarchaeota	651137|Thaumarchaeota	L	AAA ATPase domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_15
HKD1_k127_5325883_4	1229909.NSED_07575	4.314e-31	128.0	arCOG10583@1|root,arCOG10583@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5325883_3	436308.Nmar_1396	2.071e-47	176.0	COG1522@1|root,arCOG04153@2157|Archaea,41SP6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5325883_2	436308.Nmar_1395	1.226e-92	307.0	COG0293@1|root,arCOG00079@2157|Archaea,41SIK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	rlmE	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD1_k127_5325883_1	1131266.ARWQ01000010_gene24	4.5e-103	342.0	COG1867@1|root,arCOG01219@2157|Archaea,41SAG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family	-	-	2.1.1.215,2.1.1.216	ko:K00555	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TRM
HKD1_k127_5338827_0	436308.Nmar_1267	5.446e-316	977.0	COG0294@1|root,COG1410@1|root,arCOG02029@2157|Archaea,arCOG02817@2157|Archaea,41SXT@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Methionine synthase	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
HKD1_k127_5338827_1	436308.Nmar_1265	1.798e-53	194.0	COG0494@1|root,arCOG01072@2157|Archaea,41STX@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_5338827_2	1229909.NSED_07085	6.889e-17	81.0	COG2167@1|root,arCOG04177@2157|Archaea,41SUT@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL39 family	rpl39e	-	-	ko:K02924	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L39
HKD1_k127_5372993_3	1131266.ARWQ01000004_gene1400	5.439e-07	53.0	arCOG10408@1|root,arCOG10408@2157|Archaea,41T82@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5372993_1	1459636.NTE_02403	2.588e-55	198.0	COG0251@1|root,arCOG01630@2157|Archaea,41T4N@651137|Thaumarchaeota	651137|Thaumarchaeota	J	YjgF/chorismate_mutase-like, putative endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD1_k127_5372993_0	436308.Nmar_1098	2.139e-142	458.0	COG0608@1|root,arCOG00424@2157|Archaea,41SE2@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
HKD1_k127_5372993_2	436308.Nmar_1099	3.121e-43	162.0	COG0372@1|root,arCOG04237@2157|Archaea,41SAN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM 2-methylcitrate synthase citrate synthase II	-	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD1_k127_5412372_1	436308.Nmar_1647	1.031e-57	212.0	arCOG08812@1|root,arCOG08812@2157|Archaea,41T0K@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5412372_0	1131266.ARWQ01000009_gene951	3.572e-166	526.0	COG0535@1|root,arCOG00938@2157|Archaea,41SXS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_5412372_2	1131266.ARWQ01000002_gene435	3.206e-16	80.0	COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_5412372_3	436308.Nmar_1360	9.026e-06	49.0	COG2968@1|root,arCOG04715@2157|Archaea,41T6R@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD1_k127_5417166_2	1229909.NSED_02775	6.646e-163	522.0	COG0128@1|root,arCOG04134@2157|Archaea,41S5I@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_5417166_1	436308.Nmar_0547	3.774e-167	532.0	COG0082@1|root,arCOG04133@2157|Archaea,41SC3@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD1_k127_5417166_0	436308.Nmar_0546	4.045e-169	537.0	COG0436@1|root,COG1605@1|root,arCOG01130@2157|Archaea,arCOG02098@2157|Archaea,41SBV@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Chorismate mutase type II	-	-	2.6.1.1	ko:K00812	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2,CM_2
HKD1_k127_5471811_0	436308.Nmar_0243	5.954e-246	770.0	COG1204@1|root,arCOG00553@2157|Archaea,41SAK@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks	hel308	-	-	ko:K03726	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HHH_5,Helicase_C
HKD1_k127_5471811_3	1229909.NSED_01130	3.243e-137	444.0	COG0472@1|root,arCOG03199@2157|Archaea,41S8B@651137|Thaumarchaeota	651137|Thaumarchaeota	M	glycosyl transferase family	-	-	2.7.8.15	ko:K01001	ko00510,ko01100,map00510,map01100	M00055	R05969	RC00002	ko00000,ko00001,ko00002,ko01000,ko01003	-	-	-	Glycos_transf_4
HKD1_k127_5471811_8	1229909.NSED_01135	1.623e-19	91.0	arCOG11288@1|root,arCOG11288@2157|Archaea,41T86@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5471811_5	1131266.ARWQ01000008_gene296	7.469e-74	250.0	COG0110@1|root,arCOG01848@2157|Archaea,41SJ0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Hexapeptide repeat of succinyl-transferase	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_5471811_7	436308.Nmar_0246	1.33e-37	143.0	COG2835@1|root,arCOG04124@2157|Archaea,41STB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Trm112p-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Trm112p
HKD1_k127_5471811_1	436308.Nmar_0247	1.759e-145	466.0	COG0673@1|root,arCOG01622@2157|Archaea,41SZ6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	1.1.1.374	ko:K18855	-	-	-	-	ko00000,ko01000	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_5471811_2	436308.Nmar_0248	7.502e-141	452.0	COG0115@1|root,arCOG02297@2157|Archaea,41S5T@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_5471811_6	436308.Nmar_0252	2.148e-73	252.0	COG1056@1|root,arCOG00972@2157|Archaea,41SHQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Nicotinamide-nucleotide adenylyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5471811_4	1459636.NTE_02274	7.234e-91	301.0	COG1018@1|root,arCOG02200@2157|Archaea,41S72@651137|Thaumarchaeota	651137|Thaumarchaeota	C	oxidoreductase FAD NAD(P)-binding	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	FAD_binding_6,NAD_binding_1
HKD1_k127_5487192_2	1459636.NTE_01069	6.042e-07	60.0	COG1199@1|root,arCOG00770@2157|Archaea	2157|Archaea	KL	COG1199 Rad3-related DNA helicases	rad3b	-	3.6.4.12	ko:K03722,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	DEAD_2,Helicase_C_2,ResIII
HKD1_k127_5487192_0	1131266.ARWQ01000009_gene947	5.082e-90	302.0	arCOG06353@1|root,arCOG06353@2157|Archaea,41SI1@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Probable cobalt transporter subunit (CbtA)	-	-	-	-	-	-	-	-	-	-	-	-	CbtA
HKD1_k127_5487192_1	436308.Nmar_0879	5.861e-15	76.0	arCOG08746@1|root,arCOG08746@2157|Archaea,41SWA@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Probable cobalt transporter subunit (CbtB)	-	-	-	-	-	-	-	-	-	-	-	-	CbtB
HKD1_k127_548811_1	436308.Nmar_0510	1.753e-77	262.0	COG0373@1|root,arCOG01036@2157|Archaea,41SDM@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	-	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD1_k127_548811_2	1131266.ARWQ01000005_gene823	3.133e-77	263.0	COG1648@1|root,arCOG01044@2157|Archaea,41SN9@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Siroheme synthase	-	-	1.3.1.76,4.99.1.4	ko:K02304	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03947	RC01012,RC01034	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_binding_7,Sirohm_synth_M
HKD1_k127_548811_0	1131266.ARWQ01000005_gene824	4.985e-162	516.0	COG1522@1|root,arCOG01628@2157|Archaea,41SA2@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_548811_3	436308.Nmar_0514	1.159e-32	128.0	COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_5495215_2	1229909.NSED_03585	3.585e-117	380.0	COG0624@1|root,arCOG01110@2157|Archaea,41SAE@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5495215_1	1131266.ARWQ01000002_gene423	1.337e-117	384.0	COG0063@1|root,arCOG00018@2157|Archaea,41S8I@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136	ko:K17758	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase
HKD1_k127_5495215_3	436308.Nmar_0690	6.245e-114	374.0	COG2519@1|root,arCOG00978@2157|Archaea,41SEF@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	tRNA methyltransferase complex GCD14 subunit	-	-	2.1.1.219,2.1.1.220	ko:K07442	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GCD14
HKD1_k127_5495215_0	436308.Nmar_0686	5.156e-143	461.0	COG0018@1|root,arCOG00487@2157|Archaea,41SAI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_5518986_1	1131266.ARWQ01000009_gene939	9.513e-95	315.0	COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_5518986_0	436308.Nmar_1604	8.467e-141	454.0	COG0704@1|root,arCOG00318@2157|Archaea,41SC5@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Phosphate uptake regulator	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin,PhoU
HKD1_k127_5519613_2	436308.Nmar_0043	1.327e-109	364.0	COG0392@1|root,arCOG00899@2157|Archaea,41SFV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	ko:K07027	-	-	-	-	ko00000,ko02000	4.D.2	-	-	LPG_synthase_TM
HKD1_k127_5519613_1	1229909.NSED_09835	3.251e-121	392.0	COG1100@1|root,arCOG01225@2157|Archaea,41T0A@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Conserved hypothetical ATP binding protein	-	-	-	ko:K06883	-	-	-	-	ko00000	-	-	-	ATP_bind_1
HKD1_k127_5519613_0	436308.Nmar_0041	5.214e-135	435.0	COG0083@1|root,arCOG01027@2157|Archaea,41S89@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_5519613_3	1131266.ARWQ01000004_gene1466	3.356e-82	280.0	COG1024@1|root,arCOG00239@2157|Archaea,41SH7@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.116	ko:K15019	ko00720,ko01120,ko01200,map00720,map01120,map01200	M00375	R03045	RC00834	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_552907_4	1131266.ARWQ01000009_gene934	8.865e-64	224.0	COG2429@1|root,arCOG04202@2157|Archaea,41SHK@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity	gch3	-	3.5.4.29	ko:K08096	ko00740,ko01100,map00740,map01100	-	R07306	RC01790	ko00000,ko00001,ko01000	-	-	-	GCH_III
HKD1_k127_552907_0	1229909.NSED_08730	2.547e-153	495.0	COG0402@1|root,arCOG00692@2157|Archaea,41S61@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_552907_5	386456.JQKN01000003_gene265	9.528e-48	178.0	COG1985@1|root,arCOG01484@2157|Archaea,2XU47@28890|Euryarchaeota,23P0A@183925|Methanobacteria	183925|Methanobacteria	H	TIGRFAM riboflavin-specific deaminase C-terminal	ribD	-	1.1.1.302	ko:K14654	ko00740,ko01100,map00740,map01100	-	R09375,R09376	RC00933	ko00000,ko00001,ko01000	-	-	-	RibD_C
HKD1_k127_552907_2	436308.Nmar_1607	2.516e-80	270.0	COG1675@1|root,arCOG04270@2157|Archaea,41SJ8@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes	tfe	-	-	ko:K03136	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIE_alpha
HKD1_k127_552907_3	1229909.NSED_08695	3.973e-72	248.0	COG1303@1|root,arCOG01857@2157|Archaea,41SIR@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs	-	-	2.1.1.206	ko:K07254	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Trm56
HKD1_k127_552907_1	436308.Nmar_1605	5.04e-105	347.0	COG2262@1|root,arCOG00353@2157|Archaea,41SD4@651137|Thaumarchaeota	651137|Thaumarchaeota	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_5530524_1	436308.Nmar_0625	3.425e-43	161.0	COG1920@1|root,arCOG04472@2157|Archaea,41SPV@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Guanylyl transferase CofC like	-	-	2.7.7.68	ko:K14941	ko00680,ko01120,map00680,map01120	M00378	R09397	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CofC
HKD1_k127_5530524_0	436308.Nmar_0626	1.557e-158	503.0	COG0391@1|root,arCOG04395@2157|Archaea,41SCH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Uncharacterised protein family UPF0052	-	-	2.7.8.28	ko:K11212	ko00680,ko01120,map00680,map01120	M00378	R09398	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	UPF0052
HKD1_k127_5530524_2	1131266.ARWQ01000006_gene243	0.0001516	48.0	arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5545391_3	1131266.ARWQ01000012_gene1616	4.186e-38	145.0	COG0250@1|root,arCOG01920@2157|Archaea,41SM6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor Spt5	spt5	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,Spt5-NGN
HKD1_k127_5545391_4	1229909.NSED_01865	2.891e-14	74.0	COG2443@1|root,arCOG02204@2157|Archaea,41TA4@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation	-	-	-	ko:K07342	ko03060,ko04141,ko04145,ko05110,map03060,map04141,map04145,map05110	M00401	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.7,3.A.5.8,3.A.5.9	-	-	-
HKD1_k127_5545391_0	1131266.ARWQ01000012_gene1614	6.779e-118	385.0	COG1650@1|root,arCOG01616@2157|Archaea,41SM3@651137|Thaumarchaeota	651137|Thaumarchaeota	J	D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo	dtdA	-	3.1.1.96	ko:K09716	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_deacylase
HKD1_k127_5545391_1	436308.Nmar_0388	2.351e-44	162.0	COG0350@1|root,arCOG02724@2157|Archaea,41SR8@651137|Thaumarchaeota	651137|Thaumarchaeota	L	6-O-methylguanine DNA methyltransferase, DNA binding domain	-	-	2.1.1.63	ko:K00567	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_binding_1
HKD1_k127_5545391_2	1229909.NSED_01880	6.963e-42	156.0	COG2147@1|root,arCOG04089@2157|Archaea,41SVC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl19e	-	-	ko:K02885	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19e
HKD1_k127_5547661_1	1229909.NSED_02125	3.892e-44	167.0	COG0517@1|root,arCOG00601@2157|Archaea	2157|Archaea	C	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5547661_0	1229909.NSED_05640	2.416e-80	276.0	COG5012@1|root,arCOG03402@2157|Archaea	2157|Archaea	T	Cobalamin B12-binding domain protein	-	-	-	ko:K16955,ko:K22491	ko00920,map00920	-	R09997	RC00035	ko00000,ko00001,ko03000	-	-	-	B12-binding,B12-binding_2
HKD1_k127_5548062_0	1229909.NSED_04810	6.711e-195	617.0	COG4962@1|root,arCOG01817@2157|Archaea,41T25@651137|Thaumarchaeota	651137|Thaumarchaeota	N	COG0630 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis	-	-	-	ko:K07332	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD1_k127_5548062_1	1229909.NSED_04805	2.588e-46	175.0	arCOG03871@1|root,arCOG03871@2157|Archaea	2157|Archaea	S	TIGRFAM archaeal flagellin N-terminal-like domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5548062_2	1229909.NSED_04800	1.364e-22	102.0	COG2304@1|root,arCOG02900@2157|Archaea	2157|Archaea	O	von Willebrand factor, type A	-	-	-	ko:K04043,ko:K07114	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko02000,ko03019,ko03029,ko03110,ko04147	1.A.13.2.2,1.A.13.2.3,1.A.33.1	-	-	HSP70,VWA,VWA_2
HKD1_k127_5559152_6	436308.Nmar_0333	5.923e-08	55.0	arCOG08778@1|root,arCOG08778@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5559152_4	591019.Shell_0124	4.822e-13	74.0	arCOG12413@1|root,arCOG12413@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5559152_5	436308.Nmar_1547	6.113e-13	76.0	arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5559152_2	123899.JPQP01000018_gene76	7.042e-42	164.0	COG0560@1|root,COG0560@2|Bacteria,1R6HK@1224|Proteobacteria,2VUZR@28216|Betaproteobacteria,3T3CH@506|Alcaligenaceae	28216|Betaproteobacteria	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD1_k127_5559152_0	1229909.NSED_02970	1.454e-102	343.0	COG0412@1|root,arCOG10350@1|root,arCOG01659@2157|Archaea,arCOG10350@2157|Archaea,41T1E@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Chlorophyllase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD1_k127_5559152_1	1229909.NSED_09425	1.261e-68	244.0	COG3794@1|root,arCOG08795@1|root,arCOG02926@2157|Archaea,arCOG08795@2157|Archaea	2157|Archaea	C	copper ion binding	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cu-oxidase_2,Cu-oxidase_3,Cupredoxin_1
HKD1_k127_5573530_0	436308.Nmar_1769	3.859e-118	388.0	COG0531@1|root,arCOG00009@2157|Archaea,41SXX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_5573530_1	1459636.NTE_01896	4.396e-95	317.0	COG2013@1|root,arCOG01907@2157|Archaea,41T1Q@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Mitochondrial biogenesis AIM24	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD1_k127_5573530_2	436308.Nmar_0707	2.141e-26	112.0	COG2201@1|root,arCOG02382@2157|Archaea	2157|Archaea	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD1_k127_5573530_3	519442.Huta_0588	1.334e-12	73.0	COG4276@1|root,arCOG04604@2157|Archaea,2XX72@28890|Euryarchaeota,23VQW@183963|Halobacteria	183963|Halobacteria	S	Cyclase dehydrase	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc,Polyketide_cyc2
HKD1_k127_5577533_2	1229909.NSED_02165	1.202e-56	202.0	arCOG08663@1|root,arCOG08663@2157|Archaea,41SR2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5577533_1	436308.Nmar_0415	5.53e-67	230.0	arCOG08664@1|root,arCOG08664@2157|Archaea,41SKM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5577533_0	1229909.NSED_02155	4.748e-112	365.0	COG1013@1|root,arCOG01599@2157|Archaea,41SAB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Pyruvate ferredoxin oxidoreductase beta subunit C terminal	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFO_beta_C,TPP_enzyme_C
HKD1_k127_5623743_0	436308.Nmar_0444	3.977e-283	883.0	COG1215@1|root,arCOG01389@2157|Archaea,41SDD@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family group 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_5623743_1	436308.Nmar_0445	1.065e-115	388.0	COG1196@1|root,arCOG00371@2157|Archaea,41T1Y@651137|Thaumarchaeota	651137|Thaumarchaeota	D	Required for chromosome condensation and partitioning	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5623743_2	880071.Fleli_3949	1.337e-46	171.0	COG0229@1|root,COG0229@2|Bacteria,4NQEY@976|Bacteroidetes,47QG1@768503|Cytophagia	976|Bacteroidetes	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD1_k127_5627069_0	436308.Nmar_1187	1.278e-37	146.0	arCOG08690@1|root,arCOG08690@2157|Archaea,41T98@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5627069_1	1131266.ARWQ01000035_gene714	1.536e-29	124.0	arCOG08689@1|root,arCOG08689@2157|Archaea,41T5U@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5627069_3	1131266.ARWQ01000002_gene438	2.143e-18	100.0	COG0457@1|root,COG5549@1|root,arCOG03038@2157|Archaea,arCOG04994@2157|Archaea,41T10@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10,TPR_8
HKD1_k127_5643674_8	4558.Sb02g033710.1	3.453e-05	46.0	COG0105@1|root,KOG0888@2759|Eukaryota,37TR1@33090|Viridiplantae,3GI8D@35493|Streptophyta,3KZI9@4447|Liliopsida,3I9QZ@38820|Poales	35493|Streptophyta	F	Nucleoside diphosphate kinase	NDPK1	GO:0000302,GO:0003674,GO:0003824,GO:0004550,GO:0005575,GO:0005622,GO:0005623,GO:0006139,GO:0006165,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0009117,GO:0009132,GO:0009636,GO:0009987,GO:0010035,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0019205,GO:0019637,GO:0033554,GO:0034599,GO:0034614,GO:0034641,GO:0035690,GO:0042221,GO:0042493,GO:0042542,GO:0044237,GO:0044238,GO:0044281,GO:0044464,GO:0046483,GO:0046677,GO:0046939,GO:0050896,GO:0051716,GO:0055086,GO:0070301,GO:0070887,GO:0071236,GO:0071704,GO:0097237,GO:1901360,GO:1901700,GO:1901701	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_5643674_3	1131266.ARWQ01000008_gene310	2.273e-32	126.0	COG2075@1|root,arCOG01950@2157|Archaea,41T7M@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to the 23S rRNA	rpl24e	-	-	ko:K02896	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L24e
HKD1_k127_5643674_4	1131266.ARWQ01000008_gene311	1.827e-25	106.0	COG2053@1|root,arCOG04314@2157|Archaea,41ST6@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS28 family	rps28e	-	-	ko:K02979	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S28e
HKD1_k127_5643674_2	1229909.NSED_00950	8.248e-57	200.0	COG1358@1|root,arCOG01751@2157|Archaea,41SMS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H ACA, box C D and box C' D' sRNAs	rpl7ae	-	-	ko:K02936	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03009,ko03011	-	-	-	Ribosomal_L7Ae
HKD1_k127_5643674_0	1131266.ARWQ01000008_gene313	2.905e-181	577.0	COG1109@1|root,arCOG00767@2157|Archaea,41S74@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Belongs to the phosphohexose mutase family	-	-	5.4.2.2,5.4.2.8	ko:K15778	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_5643674_1	436308.Nmar_0223	7.737e-118	385.0	COG0788@1|root,arCOG02826@2157|Archaea,41S78@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Formyl transferase	-	-	3.5.1.10	ko:K01433	ko00630,ko00670,map00630,map00670	-	R00944	RC00026,RC00111	ko00000,ko00001,ko01000	-	-	-	ACT_6,Formyl_trans_N
HKD1_k127_5643674_6	1229909.NSED_00935	9.729e-09	57.0	COG1402@1|root,arCOG04536@2157|Archaea,41SNC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Creatinine amidohydrolase	-	-	3.5.2.10	ko:K01470	ko00330,map00330	-	R01884	RC00615	ko00000,ko00001,ko01000	-	-	-	Creatininase
HKD1_k127_5667324_1	525904.Tter_2274	1.476e-05	52.0	COG2141@1|root,COG2141@2|Bacteria,2NQMQ@2323|unclassified Bacteria	2|Bacteria	C	PFAM Luciferase-like monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_luciferase
HKD1_k127_5667324_0	1229909.NSED_09325	1.428e-154	495.0	COG0162@1|root,arCOG01886@2157|Archaea,41S8C@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Tyrosine--tRNA ligase	-	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	tRNA-synt_1b
HKD1_k127_56981_2	436308.Nmar_1515	1.717e-30	121.0	COG0714@1|root,arCOG00441@2157|Archaea,41SDZ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K04748	-	-	R00294	RC02794	ko00000	3.D.4.10	-	-	AAA_5
HKD1_k127_56981_1	436308.Nmar_0973	8.672e-44	169.0	arCOG08728@1|root,arCOG08728@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_56981_0	1459636.NTE_02657	1.013e-226	710.0	COG0644@1|root,arCOG00570@2157|Archaea,41SBB@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5739559_2	1131266.ARWQ01000002_gene661	7.169e-16	78.0	COG1430@1|root,arCOG03116@2157|Archaea,41SP3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD1_k127_5739559_0	436308.Nmar_0701	8.389e-310	959.0	COG0365@1|root,arCOG04201@2157|Archaea	2157|Archaea	I	COG0365 Acyl-coenzyme A synthetases AMP-(fatty) acid ligases	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C
HKD1_k127_5739559_1	1229909.NSED_03625	1.083e-24	109.0	arCOG04054@1|root,arCOG04054@2157|Archaea,41SIQ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5741923_2	436308.Nmar_0880	3.636e-38	148.0	arCOG02103@1|root,arCOG02103@2157|Archaea,41T51@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF4443)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4443
HKD1_k127_5741923_0	1229909.NSED_08640	1.646e-54	195.0	COG1607@1|root,arCOG00773@2157|Archaea,41T2J@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_5741923_3	1123355.JHYO01000015_gene1994	4.471e-11	68.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5741923_1	1459636.NTE_00785	8.599e-53	188.0	arCOG08684@1|root,arCOG08684@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5822784_6	1229909.NSED_02125	6.39e-05	48.0	COG0517@1|root,arCOG00601@2157|Archaea	2157|Archaea	C	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5822784_1	436308.Nmar_0994	5.061e-87	295.0	COG0596@1|root,arCOG01648@2157|Archaea,41SFU@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD1_k127_5822784_5	1229909.NSED_02930	6.397e-21	98.0	arCOG08754@1|root,arCOG08754@2157|Archaea	1229909.NSED_02930|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5822784_2	1229909.NSED_05710	1.268e-63	224.0	arCOG06343@1|root,arCOG06343@2157|Archaea,41SRX@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E)	-	-	-	-	-	-	-	-	-	-	-	-	PHA_synth_III_E
HKD1_k127_5822784_0	1229909.NSED_05715	6.456e-171	542.0	COG3243@1|root,arCOG06344@2157|Archaea,41SEX@651137|Thaumarchaeota	651137|Thaumarchaeota	I	TIGRFAM poly(R)-hydroxyalkanoic acid synthase, class III, PhaC subunit	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD1_k127_5822784_4	1131266.ARWQ01000002_gene518	6.867e-24	106.0	arCOG08754@1|root,arCOG08754@2157|Archaea,41SUV@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5822784_3	436308.Nmar_0993	4.442e-38	146.0	arCOG03937@1|root,arCOG03937@2157|Archaea,41SWM@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG2002 Regulators of stationary sporulation gene expression	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5849536_2	436308.Nmar_1485	7.39e-16	78.0	COG1522@1|root,arCOG01117@2157|Archaea,41ST7@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg
HKD1_k127_5849536_4	358396.C445_06568	0.0008026	49.0	COG2203@1|root,arCOG03567@1|root,arCOG02369@2157|Archaea,arCOG03567@2157|Archaea,2XUM1@28890|Euryarchaeota,23UN4@183963|Halobacteria	183963|Halobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,MEDS
HKD1_k127_5849536_3	593750.Metfor_1981	4.616e-15	76.0	arCOG03272@1|root,arCOG03272@2157|Archaea,2Y1VM@28890|Euryarchaeota,2NA39@224756|Methanomicrobia	224756|Methanomicrobia	-	-	-	-	2.7.7.6	ko:K00960	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_5849536_0	608538.HTH_1469	4.067e-38	149.0	COG0778@1|root,COG0778@2|Bacteria	2|Bacteria	C	coenzyme F420-1:gamma-L-glutamate ligase activity	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase,TM1586_NiRdase
HKD1_k127_5849536_1	1229909.NSED_02095	1.131e-37	147.0	COG3439@1|root,arCOG02761@2157|Archaea	2157|Archaea	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD1_k127_5868819_6	436308.Nmar_0503	0.0009819	49.0	arCOG12815@1|root,arCOG12815@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5868819_3	436308.Nmar_0504	1.33e-45	171.0	arCOG08762@1|root,arCOG08762@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5868819_4	1459636.NTE_02126	5.942e-22	98.0	COG1599@1|root,arCOG01510@2157|Archaea,41SV1@651137|Thaumarchaeota	651137|Thaumarchaeota	L	COG1599 Single-stranded DNA-binding replication protein A (RPA), large (70 kD) subunit and related ssDNA-binding proteins	-	-	-	ko:K07466	ko03030,ko03420,ko03430,ko03440,ko03460,map03030,map03420,map03430,map03440,map03460	M00288	-	-	ko00000,ko00001,ko00002,ko03000,ko03032,ko03400	-	-	-	tRNA_anti-codon
HKD1_k127_5868819_5	273063.STK_16450	1.739e-09	63.0	arCOG07348@1|root,arCOG07348@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5868819_1	1229909.NSED_02585	9.475e-101	332.0	COG3253@1|root,arCOG03031@2157|Archaea,41SGX@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Chlorite dismutase	-	-	-	-	-	-	-	-	-	-	-	-	Chlor_dismutase
HKD1_k127_5868819_2	1131266.ARWQ01000005_gene827	4.058e-65	227.0	COG1715@1|root,arCOG09740@2157|Archaea,41T5F@651137|Thaumarchaeota	651137|Thaumarchaeota	V	Domain of unknown function (DUF1802)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1802
HKD1_k127_5868819_0	1131266.ARWQ01000005_gene826	8.992e-141	452.0	COG0667@1|root,arCOG01617@2157|Archaea,41S90@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD1_k127_5869787_0	1229909.NSED_03260	1.622e-106	350.0	COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_5869787_1	1229909.NSED_06670	2.793e-17	85.0	arCOG08757@1|root,arCOG08757@2157|Archaea	1229909.NSED_06670|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5873977_1	436308.Nmar_1446	8.566e-40	149.0	COG3432@1|root,arCOG01055@2157|Archaea,41SST@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Winged helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_45
HKD1_k127_5873977_0	1229909.NSED_07955	6.053e-150	481.0	COG1109@1|root,arCOG00767@2157|Archaea,41SC1@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain I	-	-	-	-	-	-	-	-	-	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_5949490_0	1131266.ARWQ01000001_gene1154	1.019e-210	666.0	COG0495@1|root,arCOG00809@2157|Archaea,41SES@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_5949490_1	1131266.ARWQ01000001_gene1155	2.055e-153	490.0	COG0644@1|root,arCOG00570@2157|Archaea,41SCG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains	-	-	-	-	-	-	-	-	-	-	-	-	Trp_halogenase
HKD1_k127_5949490_2	1229909.NSED_01720	2.487e-85	285.0	COG0727@1|root,arCOG02579@2157|Archaea,41SH8@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Putative zinc- or iron-chelating domain	-	-	-	ko:K06940	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD1_k127_6036257_3	436308.Nmar_1201	1.926e-05	51.0	arCOG08777@1|root,arCOG08647@2157|Archaea,41SNX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6036257_0	1459636.NTE_01305	2.165e-58	214.0	arCOG02809@1|root,arCOG02809@2157|Archaea	2157|Archaea	V	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5
HKD1_k127_6036257_1	1459636.NTE_00860	7.89e-28	124.0	COG0382@1|root,arCOG00476@2157|Archaea	2157|Archaea	I	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.42,2.5.1.74	ko:K02548,ko:K17105,ko:K20616	ko00130,ko00564,ko01100,ko01110,map00130,map00564,map01100,map01110	M00116	R04520,R05617,R06858,R10757	RC01171,RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_6036257_2	1229909.NSED_03545	3.488e-26	112.0	COG0784@1|root,arCOG02391@2157|Archaea,41T9J@651137|Thaumarchaeota	2157|Archaea	T	COG0784 FOG CheY-like receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_6206178_0	1229909.NSED_03740	1.643e-88	295.0	arCOG05906@1|root,arCOG05906@2157|Archaea,41T21@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6261137_2	315730.BcerKBAB4_1149	7.397e-48	174.0	COG0133@1|root,COG0133@2|Bacteria,1TPI3@1239|Firmicutes,4H9WC@91061|Bacilli,1ZCBT@1386|Bacillus	91061|Bacilli	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	GO:0000162,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006082,GO:0006520,GO:0006568,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008652,GO:0009058,GO:0009072,GO:0009073,GO:0009308,GO:0009309,GO:0009987,GO:0016053,GO:0018130,GO:0019438,GO:0019752,GO:0034641,GO:0042401,GO:0042430,GO:0042435,GO:0043436,GO:0044106,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046219,GO:0046394,GO:0046483,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	4.2.1.20,5.3.1.24	ko:K01696,ko:K01817	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722,R03509	RC00209,RC00210,RC00700,RC00701,RC00945,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU22640	PALP
HKD1_k127_6261137_1	1131266.ARWQ01000002_gene475	1.008e-109	360.0	COG0159@1|root,arCOG01086@2157|Archaea,41SG0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD1_k127_6261137_0	1229909.NSED_05135	1.427e-144	461.0	COG0504@1|root,arCOG00063@2157|Archaea,41S7G@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD1_k127_6290287_2	1229909.NSED_03720	4.654e-23	99.0	COG4895@1|root,arCOG04920@2157|Archaea	2157|Archaea	S	Uncharacterized conserved protein (DUF2196)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2196
HKD1_k127_6290287_0	1459636.NTE_01667	4.466e-39	153.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41T64@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6290287_1	1229909.NSED_05705	5.101e-38	145.0	arCOG08684@1|root,arCOG08684@2157|Archaea,41ST4@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6299121_0	436308.Nmar_0642	1.137e-154	497.0	COG0389@1|root,arCOG04582@2157|Archaea,41SDV@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis	dbh	-	2.7.7.7	ko:K04479	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_6299121_6	436308.Nmar_0643	1.951e-18	87.0	arCOG08668@1|root,arCOG08668@2157|Archaea,41SW4@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6299121_3	1229909.NSED_03320	1.968e-27	113.0	COG1581@1|root,arCOG03441@1|root,arCOG01753@2157|Archaea,arCOG03441@2157|Archaea,41T5A@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Alba	-	-	-	ko:K03622	-	-	-	-	ko00000	-	-	-	Alba
HKD1_k127_6299121_7	436308.Nmar_0645	0.000108	48.0	arCOG10532@1|root,arCOG10532@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6299121_1	1229909.NSED_03335	1.95e-75	260.0	COG1938@1|root,arCOG00347@2157|Archaea,41T2Y@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PAC2 family	-	-	-	ko:K06869	-	-	-	-	ko00000	-	-	-	PAC2
HKD1_k127_6299121_4	1459636.NTE_01238	5.576e-22	97.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01238|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6299121_2	374847.Kcr_0947	6.73e-63	225.0	COG0215@1|root,arCOG00486@2157|Archaea	2157|Archaea	J	cysteinyl-tRNA synthetase	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_6299121_5	386456.JQKN01000001_gene2189	3.557e-19	92.0	COG0215@1|root,arCOG00486@2157|Archaea,2XTRY@28890|Euryarchaeota,23NUS@183925|Methanobacteria	183925|Methanobacteria	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_6299121_8	1459636.NTE_01646	0.0002311	48.0	COG0454@1|root,arCOG05161@2157|Archaea	2157|Archaea	K	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327274_2	1459636.NTE_02020	3.373e-90	302.0	COG0530@1|root,arCOG02881@2157|Archaea	2157|Archaea	P	COG0530 Ca2 Na antiporter	nce1	-	-	ko:K07301	-	-	-	-	ko00000,ko02000	2.A.19.5	-	-	Na_Ca_ex
HKD1_k127_6327274_4	1459636.NTE_01195	3.466e-21	96.0	COG1522@1|root,arCOG01117@2157|Archaea	1459636.NTE_01195|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327274_3	436308.Nmar_0585	5.863e-52	185.0	arCOG10530@1|root,arCOG10530@2157|Archaea,41T2M@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6327274_1	436308.Nmar_0582	1.501e-154	494.0	COG0150@1|root,arCOG00639@2157|Archaea,41SEE@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_6327274_0	436308.Nmar_0579	2.252e-164	521.0	COG1243@1|root,arCOG01361@2157|Archaea,41S9N@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Histone acetyltransferase	-	-	2.3.1.48	ko:K07739	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	Acetyltransf_1,Radical_SAM,Radical_SAM_C
HKD1_k127_6332794_1	1131266.ARWQ01000010_gene36	6.082e-24	101.0	arCOG11928@1|root,arCOG11928@2157|Archaea,41T8Q@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6332794_2	1229909.NSED_03230	2.643e-11	64.0	arCOG08742@1|root,arCOG08742@2157|Archaea,41SS8@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6332794_0	1131266.ARWQ01000010_gene38	1.724e-88	301.0	arCOG08732@1|root,arCOG08732@2157|Archaea,41SR6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6339451_1	1229909.NSED_07285	7.147e-106	347.0	COG2226@1|root,arCOG04348@2157|Archaea,41SGQ@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	ubiE/COQ5 methyltransferase family	-	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD1_k127_6339451_0	1229909.NSED_07310	0.0	1118.0	COG1205@1|root,arCOG08693@1|root,arCOG00555@2157|Archaea,arCOG08693@2157|Archaea,41SZS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DEAD DEAH box helicase	-	-	-	ko:K06877	-	-	-	-	ko00000	-	-	-	DEAD,DUF1998,Helicase_C
HKD1_k127_6339629_5	457429.ABJI02000787_gene6065	1.837e-11	71.0	COG2890@1|root,COG2890@2|Bacteria,2IIBT@201174|Actinobacteria	201174|Actinobacteria	J	Methyltransferase	prmC_1	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS
HKD1_k127_6339629_0	436308.Nmar_1381	9.04e-73	252.0	COG0030@1|root,arCOG04131@2157|Archaea,41SN0@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family	-	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_6339629_1	1229909.NSED_07525	1.045e-49	179.0	COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
HKD1_k127_6339629_4	1229909.NSED_07525	1.509e-25	107.0	COG1491@1|root,arCOG04130@2157|Archaea,41SGD@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Protein of unknown function (DUF655)	-	-	-	ko:K07572	-	-	-	-	ko00000	-	-	-	DUF655
HKD1_k127_6339629_3	1229909.NSED_07530	1.543e-41	154.0	COG1460@1|root,arCOG01016@2157|Archaea,41SQ1@651137|Thaumarchaeota	651137|Thaumarchaeota	K	RNA polymerase Rpb4	-	-	2.7.7.6	ko:K03051	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00184	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021	-	-	-	RNA_pol_Rpb4
HKD1_k127_6339629_2	1131266.ARWQ01000004_gene1489	5.114e-44	161.0	COG2139@1|root,arCOG04129@2157|Archaea,41SRF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eL21 family	rpl21e	-	-	ko:K02889	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21e
HKD1_k127_6343567_0	436308.Nmar_1440	6.801e-64	238.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
HKD1_k127_6383498_1	436308.Nmar_0295	2.609e-53	189.0	COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
HKD1_k127_6383498_0	1131266.ARWQ01000015_gene746	1.191e-78	264.0	COG1245@1|root,arCOG00187@2157|Archaea,41S8K@651137|Thaumarchaeota	651137|Thaumarchaeota	E	RNase L inhibitor, RLI	-	-	-	ko:K06174	-	-	-	-	ko00000,ko03009	-	-	-	ABC_tran,Fer4,RLI
HKD1_k127_6383498_3	1229909.NSED_01435	1.004e-11	67.0	arCOG08747@1|root,arCOG08747@2157|Archaea,41T48@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6394770_0	1229909.NSED_03790	1.409e-71	250.0	COG0277@1|root,arCOG00337@2157|Archaea,41T0E@651137|Thaumarchaeota	651137|Thaumarchaeota	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_6394770_1	436308.Nmar_0597	3.114e-44	163.0	COG0073@1|root,arCOG01136@2157|Archaea,41SSY@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Putative tRNA binding domain	-	-	-	ko:K06878	-	-	-	-	ko00000	-	-	-	tRNA_bind
HKD1_k127_6394770_3	1131266.ARWQ01000006_gene233	2.438e-06	49.0	arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_6394770_2	1131266.ARWQ01000006_gene233	4.551e-40	150.0	arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_6434895_1	436308.Nmar_1109	4.333e-61	212.0	COG2141@1|root,arCOG02410@2157|Archaea,41SBM@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Luciferase-like monooxygenase	-	-	-	ko:K14728	-	-	-	-	ko00000,ko01000	-	-	-	Bac_luciferase
HKD1_k127_6434895_0	436308.Nmar_1110	3.441e-161	512.0	COG1454@1|root,arCOG00984@2157|Archaea,41SFC@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Iron-containing alcohol dehydrogenase	-	-	-	ko:K18602	ko00720,ko01120,map00720,map01120	-	R09289	RC00087	ko00000,ko00001,ko01000	-	-	-	Fe-ADH
HKD1_k127_6434895_2	1131266.ARWQ01000029_gene981	1.814e-53	196.0	arCOG08793@1|root,arCOG08793@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6434895_3	1280668.ATVT01000011_gene3347	1.268e-09	64.0	COG2379@1|root,COG2379@2|Bacteria,1TSQH@1239|Firmicutes,249XX@186801|Clostridia,4BWXT@830|Butyrivibrio	186801|Clostridia	G	MOFRL family	-	-	2.7.1.165	ko:K11529	ko00030,ko00260,ko00561,ko00630,ko00680,ko01100,ko01120,ko01130,ko01200,map00030,map00260,map00561,map00630,map00680,map01100,map01120,map01130,map01200	M00346	R08572	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF4147,MOFRL
HKD1_k127_6536434_0	436308.Nmar_0008	9.821e-100	341.0	COG1252@1|root,arCOG01067@2157|Archaea	2157|Archaea	C	COG1252 NADH dehydrogenase, FAD-containing subunit	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6536434_1	1229909.NSED_09695	8.89e-09	58.0	arCOG11529@1|root,arCOG11529@2157|Archaea,41TAA@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6536624_0	1131266.ARWQ01000003_gene1504	2.42e-188	600.0	COG0165@1|root,arCOG01748@2157|Archaea,41S6A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_6536624_2	436308.Nmar_0262	5.46e-47	170.0	COG2151@1|root,arCOG01845@2157|Archaea,41SQV@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Iron-sulfur cluster assembly protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD1_k127_6536624_1	436308.Nmar_0261	1.821e-116	380.0	COG0479@1|root,arCOG00962@2157|Archaea,41SAW@651137|Thaumarchaeota	651137|Thaumarchaeota	C	TIGRFAM succinate dehydrogenase and fumarate reductase iron-sulfur protein	-	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_8
HKD1_k127_6537315_0	1229909.NSED_03500	2.55e-152	487.0	COG0031@1|root,arCOG01430@2157|Archaea,41SYM@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Cysteine synthase	-	-	2.5.1.47	ko:K12339	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6537315_1	436308.Nmar_0672	4.731e-145	464.0	COG0492@1|root,arCOG01296@2157|Archaea,41S97@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_6553208_0	436308.Nmar_1545	9.5e-145	466.0	COG1404@1|root,arCOG00704@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_6553208_4	1131266.ARWQ01000001_gene1217	3.774e-38	152.0	COG1404@1|root,arCOG00704@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_6553208_1	1229909.NSED_08495	2.162e-102	343.0	arCOG08035@1|root,arCOG08035@2157|Archaea,41SQD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6553208_3	1131266.ARWQ01000003_gene1513	8.494e-71	244.0	COG0406@1|root,arCOG01991@2157|Archaea,41SJM@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Phosphoglycerate mutase family	-	-	5.4.2.12	ko:K15634	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD1_k127_6553208_2	436308.Nmar_0180	2.866e-97	322.0	COG2085@1|root,arCOG00457@2157|Archaea,41SH2@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM NADP oxidoreductase coenzyme F420-dependent	-	-	1.5.1.40	ko:K06988	-	-	-	-	ko00000,ko01000	-	-	-	F420_oxidored
HKD1_k127_6564116_2	1229909.NSED_04530	5.321e-35	136.0	COG0156@1|root,arCOG00113@2157|Archaea,41SAP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	8-amino-7-oxononanoate synthase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_6564116_0	1229909.NSED_04525	6.849e-94	313.0	COG0785@1|root,arCOG02398@2157|Archaea,41SZE@651137|Thaumarchaeota	651137|Thaumarchaeota	O	cytochrome c biogenesis protein	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	DsbD
HKD1_k127_6564116_1	1229909.NSED_04520	1.066e-90	306.0	arCOG03562@1|root,arCOG03562@2157|Archaea,41SY7@651137|Thaumarchaeota	651137|Thaumarchaeota	O	AhpC/TSA family	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA
HKD1_k127_656629_0	1459636.NTE_02343	2.277e-109	362.0	COG0840@1|root,arCOG02320@2157|Archaea	2157|Archaea	T	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
HKD1_k127_656629_1	1459636.NTE_02340	1.097e-74	268.0	COG0840@1|root,arCOG02344@2157|Archaea	2157|Archaea	T	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	HAMP,MCPsignal
HKD1_k127_656629_2	1459636.NTE_02345	1.274e-28	119.0	COG0835@1|root,arCOG02395@2157|Archaea	2157|Archaea	NT	Chemotaxis signal transduction protein	cheW2	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD1_k127_6580468_1	1131266.ARWQ01000001_gene1217	1.823e-112	376.0	COG1404@1|root,arCOG00704@2157|Archaea,41SEM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD1_k127_6580468_3	485914.Hmuk_2473	1.789e-06	57.0	COG0723@1|root,arCOG01720@2157|Archaea,2XUXF@28890|Euryarchaeota,23U4Y@183963|Halobacteria	183963|Halobacteria	C	COG0723 Rieske Fe-S protein	petA	-	-	ko:K15878	-	-	-	-	ko00000	-	-	-	Rieske
HKD1_k127_6580468_0	1229909.NSED_08480	9.673e-240	747.0	COG1290@1|root,arCOG01721@2157|Archaea,41SDA@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Cytochrome b subunit of the bc complex	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD1_k127_6580468_2	1131266.ARWQ01000001_gene1214	6.413e-41	154.0	COG3794@1|root,arCOG02926@2157|Archaea,41SPG@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Copper binding proteins, plastocyanin azurin family	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD1_k127_6604366_3	1131266.ARWQ01000009_gene955	1.158e-63	225.0	COG0079@1|root,arCOG04273@2157|Archaea,41SGU@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM Aminotransferase class I and II	-	-	4.1.1.81	ko:K04720	ko00860,map00860	-	R06530	RC00517	ko00000,ko00001,ko01000	-	-	-	Aminotran_1_2
HKD1_k127_6604366_0	1459636.NTE_03113	2.67e-173	549.0	COG0136@1|root,arCOG00494@2157|Archaea,41SFD@651137|Thaumarchaeota	651137|Thaumarchaeota	E	aspartate-semialdehyde dehydrogenase	-	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_6604366_4	1459636.NTE_03112	1.286e-62	218.0	COG1522@1|root,arCOG01580@2157|Archaea,41SKI@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Lrp/AsnC ligand binding domain	-	-	-	ko:K03718	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
HKD1_k127_6604366_2	1131266.ARWQ01000009_gene952	3.714e-143	458.0	COG0109@1|root,arCOG00479@2157|Archaea,41SFH@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	-	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD1_k127_6604366_1	1229909.NSED_08645	2.799e-163	520.0	COG0043@1|root,arCOG01671@2157|Archaea,41SEQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	-	-	-	-	-	-	-	-	-	-	UbiD
HKD1_k127_662083_2	436308.Nmar_0819	1.467e-92	311.0	COG0156@1|root,arCOG00113@2157|Archaea,41SAP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	8-amino-7-oxononanoate synthase	-	-	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_662083_1	1459636.NTE_01791	1.606e-114	377.0	COG0502@1|root,arCOG00658@2157|Archaea,41S9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_662083_0	1229909.NSED_04540	1.108e-181	578.0	COG0161@1|root,arCOG00917@2157|Archaea,41S7K@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_6624948_2	1229909.NSED_00400	1.56e-67	235.0	COG2132@1|root,arCOG03914@2157|Archaea,41T22@651137|Thaumarchaeota	651137|Thaumarchaeota	Q	Multicopper oxidase	-	-	1.7.2.1	ko:K00368	ko00910,ko01120,map00910,map01120	M00529	R00783,R00785	RC00086	ko00000,ko00001,ko00002,ko01000	-	-	-	Copper-bind
HKD1_k127_6624948_3	1131266.ARWQ01000003_gene1508	2.178e-57	203.0	COG0109@1|root,arCOG03103@2157|Archaea,41SNT@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Cytochrome oxidase assembly protein	-	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD1_k127_6624948_5	436308.Nmar_0187	2.348e-18	93.0	arCOG08825@1|root,arCOG08825@2157|Archaea,41T4G@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6624948_1	436308.Nmar_0188	1.23e-92	308.0	COG4276@1|root,arCOG04604@2157|Archaea,41SI9@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_6624948_4	436308.Nmar_0191	9.166e-19	86.0	arCOG08759@1|root,arCOG08759@2157|Archaea,41T9Q@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6624948_6	1229909.NSED_04035	1.287e-15	77.0	arCOG08803@1|root,arCOG08803@2157|Archaea	2157|Archaea	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6624948_0	436308.Nmar_0192	2.822e-148	473.0	COG0115@1|root,arCOG02297@2157|Archaea,41SD5@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_6659877_3	436308.Nmar_0066	9.309e-15	74.0	COG1467@1|root,arCOG04110@2157|Archaea,41SCB@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priS	-	-	ko:K02683	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_S
HKD1_k127_6659877_0	436308.Nmar_0067	0.0	1286.0	COG1615@1|root,arCOG06128@2157|Archaea,41SCS@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Uncharacterised protein family (UPF0182)	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD1_k127_6659877_1	1131266.ARWQ01000001_gene1289	4.998e-34	135.0	COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_6659877_4	1131266.ARWQ01000001_gene1289	1.077e-05	47.0	COG0518@1|root,arCOG00087@2157|Archaea,41SQR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	glutamine amidotransferase	-	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase
HKD1_k127_6659877_2	1229909.NSED_00040	5.428e-31	123.0	COG0457@1|root,arCOG03032@2157|Archaea,41T0V@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1
HKD1_k127_6668418_7	1459636.NTE_01827	3.585e-15	75.0	COG0093@1|root,arCOG04095@2157|Archaea,41SHG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rpl14	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD1_k127_6668418_4	1229909.NSED_04435	2.923e-39	153.0	COG0198@1|root,arCOG04094@2157|Archaea,41SSS@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Located at the polypeptide exit tunnel on the outside of the subunit	rpl24	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L26
HKD1_k127_6668418_0	1229909.NSED_04430	3.428e-97	322.0	COG1471@1|root,arCOG04093@2157|Archaea,41SIE@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS4 family	rps4e	-	-	ko:K02987	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	RS4NT,Ribosomal_S4e,S4
HKD1_k127_6668418_1	1229909.NSED_04425	3.246e-74	253.0	COG0094@1|root,arCOG04092@2157|Archaea,41SJP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rpl5	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD1_k127_6668418_6	1229909.NSED_04420	2.017e-24	102.0	COG0199@1|root,arCOG00782@2157|Archaea,41SW8@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein S14	rps14	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD1_k127_6668418_2	436308.Nmar_0795	3.703e-66	227.0	COG0096@1|root,arCOG04091@2157|Archaea,41SMM@651137|Thaumarchaeota	651137|Thaumarchaeota	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rps8	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD1_k127_6668418_3	1459636.NTE_01821	1.813e-50	184.0	COG0097@1|root,arCOG04090@2157|Archaea,41SJG@651137|Thaumarchaeota	651137|Thaumarchaeota	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rpl6	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD1_k127_6668418_5	1229909.NSED_04400	2.862e-36	139.0	arCOG08711@1|root,arCOG08711@2157|Archaea,41T4I@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6694534_1	1131266.ARWQ01000012_gene1605	4.3e-76	259.0	COG1102@1|root,arCOG01037@2157|Archaea,41SKS@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the cytidylate kinase family. Type 2 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin2
HKD1_k127_6694534_2	1131266.ARWQ01000012_gene1604	1.84e-72	250.0	COG1422@1|root,arCOG02673@2157|Archaea,41SNR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF106
HKD1_k127_6694534_3	1459636.NTE_02793	1.303e-55	200.0	COG2019@1|root,arCOG01039@2157|Archaea,41SK7@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the archaeal adenylate kinase family	adkA	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AAA_17
HKD1_k127_6694534_0	1229909.NSED_01945	3.068e-158	503.0	COG5253@1|root,arCOG04169@2157|Archaea,41S9X@651137|Thaumarchaeota	651137|Thaumarchaeota	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	Plug_translocon,SecY
HKD1_k127_6725797_1	436308.Nmar_0100	1.653e-144	464.0	COG0252@1|root,arCOG01924@2157|Archaea,41SD7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatD	-	6.3.5.7	ko:K09482	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD1_k127_6725797_0	1131266.ARWQ01000001_gene1257	1.048e-195	622.0	COG2511@1|root,arCOG01719@2157|Archaea,41S8Q@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate	gatE	-	6.3.5.7	ko:K03330	ko00970,ko01100,map00970,map01100	-	R03905	RC00010	ko00000,ko00001,ko01000	-	-	-	GAD,GatB_N,GatB_Yqey
HKD1_k127_674906_0	436308.Nmar_0537	1.812e-154	493.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD1_k127_674906_3	1122214.AQWH01000009_gene2066	1.101e-35	140.0	COG1047@1|root,COG1047@2|Bacteria,1RD35@1224|Proteobacteria,2U79E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidyl-prolyl cis-trans	slyD	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	FKBP_C
HKD1_k127_674906_2	1229909.NSED_08715	4.314e-68	235.0	COG3945@1|root,arCOG01471@2157|Archaea,41T3D@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Hemerythrin HHE cation binding	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_674906_1	1131266.ARWQ01000005_gene847	1.108e-115	377.0	COG1085@1|root,arCOG00422@2157|Archaea,41S6T@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Galactose-1-phosphate uridyl transferase, N-terminal domain	-	-	2.7.7.12	ko:K00965	ko00052,ko00520,ko01100,ko04917,map00052,map00520,map01100,map04917	M00362,M00554,M00632	R00955	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	GalP_UDP_transf
HKD1_k127_682871_2	1131266.ARWQ01000001_gene1105	6.648e-79	271.0	arCOG01449@1|root,arCOG01449@2157|Archaea	2157|Archaea	-	-	-	-	-	ko:K07725	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	-
HKD1_k127_682871_4	436308.Nmar_0025	3.476e-13	71.0	arCOG08813@1|root,arCOG08813@2157|Archaea,41T88@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_682871_1	1229909.NSED_09770	3.341e-106	349.0	COG1028@1|root,arCOG01259@2157|Archaea,41SXY@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Short-chain dehydrogenase reductase SDR	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_682871_0	1459636.NTE_01473	7.308e-167	527.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
HKD1_k127_682871_3	436308.Nmar_0029	1.883e-24	104.0	COG5491@1|root,arCOG00452@2157|Archaea,41SYC@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6928656_4	1131266.ARWQ01000001_gene1271	6.268e-29	117.0	COG1903@1|root,arCOG04383@2157|Archaea,41S70@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A	cbiD	-	2.1.1.195	ko:K02188	ko00860,ko01100,map00860,map01100	-	R07773	RC00003,RC02051	ko00000,ko00001,ko01000	-	-	-	CbiD
HKD1_k127_6928656_1	1131266.ARWQ01000001_gene1272	1.714e-145	468.0	COG2073@1|root,arCOG00651@2157|Archaea,41S83@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Cobalamin synthesis G C-terminus	-	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N,CbiG_mid
HKD1_k127_6928656_2	1131266.ARWQ01000001_gene1273	1.173e-111	366.0	COG2138@1|root,arCOG02246@2157|Archaea,41SH6@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Cobalt chelatase (CbiK)	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiX
HKD1_k127_6928656_3	436308.Nmar_0080	2.564e-87	293.0	COG2082@1|root,arCOG02247@2157|Archaea,41SXG@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Precorrin-8X methylmutase	-	-	5.4.99.60,5.4.99.61	ko:K06042	ko00860,ko01100,map00860,map01100	-	R05177,R05814	RC01292,RC01980	ko00000,ko00001,ko01000	-	-	-	CbiC
HKD1_k127_6928656_0	436308.Nmar_0079	1.187e-154	497.0	COG1797@1|root,arCOG00106@2157|Archaea,41SBP@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	CbiA,GATase_3
HKD1_k127_698881_0	1229909.NSED_02185	4.959e-187	589.0	COG0065@1|root,arCOG01698@2157|Archaea,41S7A@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35	ko:K01703	ko00290,ko00660,ko00966,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map00966,map01100,map01110,map01210,map01230	M00432,M00535	R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase
HKD1_k127_698881_1	436308.Nmar_0419	1.598e-91	308.0	COG1478@1|root,arCOG02714@2157|Archaea,41SHA@651137|Thaumarchaeota	651137|Thaumarchaeota	H	F420-0:Gamma-glutamyl ligase	-	-	-	-	-	-	-	-	-	-	-	-	F420_ligase
HKD1_k127_698881_2	1131266.ARWQ01000030_gene986	4.299e-76	258.0	arCOG04033@1|root,arCOG04033@2157|Archaea,41SM5@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7025421_0	1229909.NSED_07165	1.722e-159	507.0	COG4992@1|root,arCOG00914@2157|Archaea,41SC8@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	lysJ	-	-	ko:K05830	ko00220,ko00300,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01130,map01210,map01230	M00031,M00763	R09778,R10932	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7025421_1	1459636.NTE_00737	3.135e-44	164.0	COG1522@1|root,arCOG01580@2157|Archaea,41SNE@651137|Thaumarchaeota	651137|Thaumarchaeota	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
HKD1_k127_7095079_2	485913.Krac_2923	2.957e-28	117.0	COG0428@1|root,COG0428@2|Bacteria,2G9IR@200795|Chloroflexi	200795|Chloroflexi	P	transporter	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7095079_0	1229909.NSED_04890	7.675e-165	524.0	COG1759@1|root,arCOG04346@2157|Archaea,41SBR@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates	purP	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
HKD1_k127_7095079_4	1229909.NSED_04885	1.887e-08	58.0	arCOG11517@1|root,arCOG11517@2157|Archaea,41TAE@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7095079_1	1229909.NSED_07540	7.372e-161	513.0	COG0731@1|root,arCOG00953@2157|Archaea	2157|Archaea	C	Radical SAM domain protein	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_7098458_1	436308.Nmar_0620	4.31e-46	174.0	COG3356@1|root,arCOG04351@2157|Archaea,41S7S@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Predicted membrane protein (DUF2070)	-	-	-	ko:K08979	-	-	-	-	ko00000	-	-	-	DUF2070
HKD1_k127_7098458_4	1229909.NSED_03195	7.365e-17	81.0	COG4023@1|root,arCOG02957@2157|Archaea,41SUS@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Sec61beta family	-	-	-	-	-	-	-	-	-	-	-	-	Sec61_beta
HKD1_k127_7098458_3	436308.Nmar_0621	7.042e-25	107.0	COG1645@1|root,arCOG00578@2157|Archaea,41SVN@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27)	-	-	-	ko:K07143	-	-	-	-	ko00000	-	-	-	Auto_anti-p27
HKD1_k127_7098458_0	436308.Nmar_0622	1.373e-47	171.0	COG0023@1|root,arCOG04223@2157|Archaea,41SNU@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the SUI1 family	-	-	-	ko:K03113	ko03013,map03013	-	-	-	ko00000,ko00001,ko03012	-	-	-	SUI1
HKD1_k127_7098458_2	1131266.ARWQ01000006_gene246	7.513e-27	113.0	arCOG08741@1|root,arCOG08741@2157|Archaea,41SWQ@651137|Thaumarchaeota	651137|Thaumarchaeota	E	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD1_k127_7125968_1	1131266.ARWQ01000009_gene962	8.212e-116	381.0	COG1001@1|root,arCOG00693@2157|Archaea,41SZH@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HKD1_k127_7125968_0	436308.Nmar_1577	3.285e-282	874.0	COG0459@1|root,arCOG01257@2157|Archaea,41T11@651137|Thaumarchaeota	651137|Thaumarchaeota	O	TCP-1/cpn60 chaperonin family	-	-	-	ko:K22447	-	-	-	-	ko00000,ko03110	-	-	-	Cpn60_TCP1
HKD1_k127_7125968_2	1459636.NTE_03124	5.505e-63	225.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
HKD1_k127_7127840_2	436308.Nmar_0666	6.487e-106	346.0	COG0560@1|root,arCOG01158@2157|Archaea,41SHX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	phosphoserine phosphatase	-	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
HKD1_k127_7127840_3	436308.Nmar_0659	5.9e-35	138.0	arCOG07440@1|root,arCOG07440@2157|Archaea,41STP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7127840_0	1131266.ARWQ01000011_gene105	2.654e-232	726.0	COG0008@1|root,arCOG00402@2157|Archaea,41SFI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b
HKD1_k127_7127840_4	1459636.NTE_03540	1.107e-30	127.0	COG3794@1|root,arCOG02929@2157|Archaea,41T61@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Cupredoxin-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD1_k127_7127840_1	1459636.NTE_01021	4.62e-123	406.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Trypsin-like serine protease with C-terminal PDZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_7127840_5	436308.Nmar_1057	3.27e-19	88.0	COG2094@1|root,arCOG04295@2157|Archaea,41SME@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD1_k127_7143013_1	1131266.ARWQ01000002_gene596	2.606e-83	280.0	COG0163@1|root,arCOG01703@2157|Archaea,41SHU@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_7143013_2	436308.Nmar_1406	3.721e-58	207.0	COG0071@1|root,arCOG01833@2157|Archaea	2157|Archaea	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7143013_0	436308.Nmar_1407	2.116e-123	397.0	COG1697@1|root,arCOG04143@2157|Archaea,41SQF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Relaxes both positive and negative superturns and exhibits a strong decatenase activity	top6A	-	5.99.1.3	ko:K03166	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	TP6A_N
HKD1_k127_7219493_4	1131266.ARWQ01000004_gene1475	5.386e-11	65.0	arCOG08648@1|root,arCOG08648@2157|Archaea,41T9C@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7219493_2	1229909.NSED_02800	1.011e-175	556.0	COG1465@1|root,arCOG04353@2157|Archaea,41S88@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis	aroB'	-	1.4.1.24	ko:K11646	ko00400,ko01110,ko01130,map00400,map01110,map01130	-	R08569	RC02302	ko00000,ko00001,ko01000	-	-	-	DHQS
HKD1_k127_7219493_3	1131266.ARWQ01000017_gene886	4.663e-127	412.0	COG1830@1|root,arCOG04044@2157|Archaea,41SCP@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes a transaldol reaction between 6-deoxy-5- ketofructose 1-phosphate (DKFP) and L-aspartate semialdehyde (ASA) with an elimination of hydroxypyruvaldehyde phosphate to yield 2- amino-3,7-dideoxy-D-threo-hept-6-ulosonate (ADH). Plays a key role in an alternative pathway of the biosynthesis of 3-dehydroquinate (DHQ), which is involved in the canonical pathway for the biosynthesis of aromatic amino acids	aroA'	-	2.2.1.10,4.1.2.13	ko:K16306	ko00010,ko00030,ko00051,ko00400,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00400,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001	R01068,R01070,R02568,R08568	RC00438,RC00439,RC00721,RC02301	ko00000,ko00001,ko00002,ko01000	-	-	-	DeoC
HKD1_k127_7219493_0	436308.Nmar_0554	8.13e-187	589.0	COG1060@1|root,arCOG00656@2157|Archaea,41SCN@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2)	mqnC	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_7219493_1	1229909.NSED_02815	1.622e-177	558.0	COG0043@1|root,arCOG01671@2157|Archaea,41S94@651137|Thaumarchaeota	651137|Thaumarchaeota	H	UbiD family decarboxylase	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_7234769_4	1229909.NSED_08280	7.842e-13	69.0	arCOG08673@1|root,arCOG08673@2157|Archaea,41SVK@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7234769_2	436308.Nmar_1506	4.589e-36	139.0	arCOG08672@1|root,arCOG08672@2157|Archaea,41SU2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7234769_3	1131266.ARWQ01000001_gene1139	2.218e-17	85.0	arCOG10587@1|root,arCOG10587@2157|Archaea,41SVM@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7234769_1	436308.Nmar_1508	1.644e-64	224.0	COG0184@1|root,arCOG04185@2157|Archaea,41SKP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	ribosomal protein	rps15	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13_N,Ribosomal_S15
HKD1_k127_7234769_0	436308.Nmar_1509	9.799e-204	642.0	COG0608@1|root,arCOG00427@2157|Archaea,41SZF@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DHHA1 domain	-	-	-	ko:K07463	-	-	-	-	ko00000	-	-	-	DHHA1
HKD1_k127_7243283_7	1229909.NSED_08150	1.853e-72	247.0	COG0311@1|root,arCOG00034@2157|Archaea,41SIZ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS	pdxT	-	4.3.3.6	ko:K08681	ko00750,map00750	-	R07456	RC00010,RC01783,RC03043	ko00000,ko00001,ko01000	-	-	-	SNO
HKD1_k127_7243283_0	1459636.NTE_01231	0.0	1190.0	COG1048@1|root,arCOG01697@2157|Archaea,41SE6@651137|Thaumarchaeota	651137|Thaumarchaeota	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_7243283_11	436308.Nmar_1112	7.732e-25	105.0	arCOG08646@1|root,arCOG08646@2157|Archaea,41T7H@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7243283_4	1459636.NTE_03215	5.798e-91	309.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	2157|Archaea	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7243283_6	436308.Nmar_1440	1.757e-77	277.0	COG0642@1|root,arCOG02358@2157|Archaea,41T5G@651137|Thaumarchaeota	651137|Thaumarchaeota	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
HKD1_k127_7243283_8	436308.Nmar_0233	7.87e-57	200.0	COG3324@1|root,arCOG04946@2157|Archaea,41T3T@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_7243283_1	1229909.NSED_08040	0.0	1079.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_7243283_9	1229909.NSED_08040	1.546e-53	189.0	COG0525@1|root,arCOG00808@2157|Archaea,41SBK@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Anticodon-binding domain of tRNA	-	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_7243283_3	436308.Nmar_1469	1.503e-126	410.0	COG0720@1|root,arCOG02172@2157|Archaea,41SY8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	6-pyruvoyl tetrahydropterin synthase	-	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_7243283_10	1131266.ARWQ01000001_gene1089	4.015e-39	147.0	COG2154@1|root,arCOG02939@2157|Archaea,41SSQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	pterin-4-alpha-carbinolamine dehydratase	-	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD1_k127_7243283_5	436308.Nmar_1466	2.617e-83	284.0	COG0367@1|root,arCOG00071@2157|Archaea,41SIX@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
HKD1_k127_7243283_2	1229909.NSED_08020	1.038e-210	663.0	COG0015@1|root,arCOG01747@2157|Archaea,41SD1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	adenylosuccinate lyase	-	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD1_k127_7251324_0	1459636.NTE_03132	6.673e-130	423.0	COG0715@1|root,arCOG01803@2157|Archaea,41SG5@651137|Thaumarchaeota	651137|Thaumarchaeota	P	TIGRFAM ABC transporter, substrate-binding protein, aliphatic sulfonates family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1_2
HKD1_k127_7251324_1	436308.Nmar_1644	3.633e-59	218.0	arCOG08728@1|root,arCOG08728@2157|Archaea,41SW1@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7251324_2	1131266.ARWQ01000004_gene1444	5.848e-39	148.0	COG0685@1|root,arCOG00475@2157|Archaea,41SNK@651137|Thaumarchaeota	651137|Thaumarchaeota	E	cytochrome-c peroxidase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_731298_1	1229909.NSED_05545	3.292e-75	254.0	COG0143@1|root,arCOG00810@2157|Archaea,41SAF@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HKD1_k127_731298_0	1131266.ARWQ01000002_gene447	1.672e-211	662.0	COG0499@1|root,arCOG04137@2157|Archaea,41S9I@651137|Thaumarchaeota	651137|Thaumarchaeota	H	S-adenosyl-L-homocysteine hydrolase, NAD binding domain	-	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD1_k127_731298_2	436308.Nmar_0965	4.566e-48	173.0	COG2146@1|root,arCOG02854@2157|Archaea,41STC@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Rieske-like [2Fe-2S] domain	-	-	-	ko:K05710	ko00360,ko01120,ko01220,map00360,map01120,map01220	M00545	R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002	-	-	-	Rieske
HKD1_k127_731298_3	1229909.NSED_05565	4.242e-34	134.0	COG0171@1|root,arCOG00069@2157|Archaea,41SJ9@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	NAD_synthase
HKD1_k127_7344910_0	1229909.NSED_00845	3.588e-13	79.0	COG0681@1|root,arCOG01739@2157|Archaea,41SQ2@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Signal peptidase	-	-	3.4.21.89	ko:K13280	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_7344910_2	1229909.NSED_04395	0.0001471	52.0	arCOG11516@1|root,arCOG11516@2157|Archaea,41T9Y@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7344910_1	436308.Nmar_0974	0.0001268	44.0	COG1683@1|root,arCOG04848@2157|Archaea	2157|Archaea	S	Protein of unknown function (DUF1722)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1722,DUF523
HKD1_k127_7376757_0	1131266.ARWQ01000002_gene482	2.522e-297	921.0	COG0441@1|root,arCOG00401@2157|Archaea,41S9K@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the class-II aminoacyl-tRNA synthetase family	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-Thr_ED,tRNA-synt_2b
HKD1_k127_7376757_2	1229909.NSED_04025	1.779e-22	98.0	COG0457@1|root,arCOG03032@2157|Archaea,41T66@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_1
HKD1_k127_7376757_1	436308.Nmar_0925	2.044e-107	351.0	COG0010@1|root,arCOG01700@2157|Archaea,41T03@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_7378336_2	1131266.ARWQ01000006_gene233	1.035e-24	104.0	arCOG05400@1|root,arCOG05400@2157|Archaea,41SQH@651137|Thaumarchaeota	651137|Thaumarchaeota	S	PFAM Polyketide cyclase dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD1_k127_7378336_0	1131266.ARWQ01000006_gene232	8.756e-173	550.0	arCOG01390@1|root,arCOG01390@2157|Archaea,41S7Q@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Glycosyl transferase family 21	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_7378336_1	436308.Nmar_1146	2.829e-50	185.0	COG0265@1|root,arCOG02833@2157|Archaea,41S9W@651137|Thaumarchaeota	2157|Archaea	O	Trypsin-like serine protease with C-terminal PDZ domain	degP	-	-	-	-	-	-	-	-	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_7380116_0	1229909.NSED_08780	1.048e-197	619.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_7380116_1	1131266.ARWQ01000009_gene916	2.16e-66	229.0	COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota	651137|Thaumarchaeota	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_7391640_0	1459636.NTE_03124	3.057e-80	275.0	COG0524@1|root,arCOG00014@2157|Archaea	2157|Archaea	G	Belongs to the carbohydrate kinase PfkB family	-	-	2.7.1.15	ko:K00852	ko00030,map00030	-	R01051,R02750	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PfkB,Regulator_TrmB,TrmB
HKD1_k127_7391640_1	378806.STAUR_5067	5.467e-16	86.0	COG0747@1|root,COG0747@2|Bacteria,1QX9G@1224|Proteobacteria,43C2P@68525|delta/epsilon subdivisions,2X7D9@28221|Deltaproteobacteria	28221|Deltaproteobacteria	E	Fungalysin metallopeptidase (M36)	-	-	-	-	-	-	-	-	-	-	-	-	FTP,PA,Peptidase_M36,REJ
HKD1_k127_7413862_0	1131266.ARWQ01000006_gene252	6.68e-89	303.0	COG3889@1|root,arCOG01672@2157|Archaea,41SA5@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_7413862_1	436308.Nmar_0719	1.711e-63	221.0	COG0601@1|root,arCOG00751@2157|Archaea,41S7B@651137|Thaumarchaeota	651137|Thaumarchaeota	P	inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_7415300_0	1459636.NTE_01473	1.812e-63	226.0	COG1405@1|root,arCOG01981@2157|Archaea,41SXZ@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB)	-	-	-	ko:K03124	ko03022,ko05169,ko05203,map03022,map05169,map05203	-	-	-	ko00000,ko00001,ko03021	-	-	-	TFIIB,TF_Zn_Ribbon
HKD1_k127_7463819_2	1229909.NSED_10020	8.313e-10	66.0	28H64@1|root,2N564@2157|Archaea,41T1P@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7463819_0	1229909.NSED_09935	1.082e-100	331.0	COG5491@1|root,arCOG00452@2157|Archaea,41SJ3@651137|Thaumarchaeota	651137|Thaumarchaeota	D	conserved protein implicated in secretion	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7463819_1	1229909.NSED_09930	4.072e-42	158.0	COG1794@1|root,arCOG02005@2157|Archaea,41SM4@651137|Thaumarchaeota	651137|Thaumarchaeota	M	Asp/Glu/Hydantoin racemase	-	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD1_k127_7464308_0	436308.Nmar_0008	2.062e-197	623.0	COG1252@1|root,arCOG01067@2157|Archaea	2157|Archaea	C	COG1252 NADH dehydrogenase, FAD-containing subunit	ndh2	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_7464308_3	436308.Nmar_0417	7.477e-39	147.0	arCOG10524@1|root,arCOG10524@2157|Archaea,41SVP@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7464308_1	436308.Nmar_0009	1.748e-78	267.0	arCOG01806@1|root,arCOG01806@2157|Archaea,41T2B@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7464308_2	1229909.NSED_09685	4.393e-55	198.0	COG0071@1|root,arCOG01833@2157|Archaea,41SPJ@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD1_k127_7468069_0	574375.BAGA_16095	1.347e-23	104.0	COG3391@1|root,COG5164@1|root,COG3391@2|Bacteria,COG5164@2|Bacteria,1VFKD@1239|Firmicutes,4ISEA@91061|Bacilli,1ZS7Y@1386|Bacillus	91061|Bacilli	K	Collagen triple helix repeat (20 copies)	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
HKD1_k127_7468069_1	314292.VAS14_15634	1.168e-14	76.0	COG3042@1|root,COG3042@2|Bacteria,1QKE0@1224|Proteobacteria,1TIHX@1236|Gammaproteobacteria,1XZ5Q@135623|Vibrionales	135623|Vibrionales	S	Domain of unknown function (DUF333)	-	-	-	-	-	-	-	-	-	-	-	-	DUF333
HKD1_k127_7476602_2	1131266.ARWQ01000002_gene670	3.952e-46	169.0	COG0017@1|root,arCOG00406@2157|Archaea,41S93@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	-	-	-	-	-	-	-	-	-	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_7476602_1	1229909.NSED_06220	1.876e-58	209.0	COG0195@1|root,arCOG01761@2157|Archaea,41T4Q@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Transcription elongation factor	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7476602_0	1131266.ARWQ01000002_gene669	6.271e-120	394.0	COG0444@1|root,arCOG00181@2157|Archaea,41S9V@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_7539644_2	547559.Nmag_2046	5.925e-12	70.0	COG1215@1|root,arCOG01389@2157|Archaea,2XVEG@28890|Euryarchaeota,23UEZ@183963|Halobacteria	183963|Halobacteria	M	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_7539644_0	1459636.NTE_03070	8.592e-28	130.0	COG0726@1|root,arCOG02876@2157|Archaea,41T20@651137|Thaumarchaeota	2157|Archaea	G	xylanase chitin deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	CHB_HEX_C_1,HYR,Polysacc_deac_1
HKD1_k127_7539644_3	1131266.ARWQ01000002_gene627	1.34e-10	66.0	arCOG08660@1|root,arCOG08660@2157|Archaea,41T60@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7539644_1	1229909.NSED_03685	2.305e-15	81.0	arCOG05201@1|root,arCOG05201@2157|Archaea	2157|Archaea	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7566012_1	1229909.NSED_09815	5.322e-82	276.0	COG0302@1|root,arCOG04542@2157|Archaea,41SGC@651137|Thaumarchaeota	651137|Thaumarchaeota	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_7566012_0	1229909.NSED_09810	3.102e-102	337.0	COG0602@1|root,arCOG02173@2157|Archaea,41SGM@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_761501_5	436308.Nmar_0520	3.301e-22	98.0	COG2007@1|root,arCOG04154@2157|Archaea,41SP2@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Ribosomal protein S8e	rps8e	-	-	ko:K02995	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8e
HKD1_k127_761501_1	1229909.NSED_02620	5.711e-78	264.0	COG1386@1|root,arCOG02613@2157|Archaea,41SIC@651137|Thaumarchaeota	651137|Thaumarchaeota	K	segregation and condensation protein	-	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD1_k127_761501_0	436308.Nmar_0522	2.415e-85	287.0	COG1354@1|root,arCOG02610@2157|Archaea,41SMU@651137|Thaumarchaeota	651137|Thaumarchaeota	L	chromosome segregation and condensation protein ScpA	-	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	-
HKD1_k127_761501_3	1229909.NSED_02635	3.491e-54	199.0	COG0784@1|root,arCOG02391@2157|Archaea	2157|Archaea	T	response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_761501_2	1229909.NSED_02640	1.821e-57	204.0	COG1522@1|root,arCOG01580@2157|Archaea	1229909.NSED_02640|-	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_761501_4	1229909.NSED_02660	1.096e-45	172.0	arCOG08739@1|root,arCOG08739@2157|Archaea,41SN6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_761501_6	1229909.NSED_02665	8.91e-19	87.0	COG0231@1|root,arCOG04277@2157|Archaea,41SNP@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Functions by promoting the formation of the first peptide bond	eif5a	-	-	ko:K03263	-	-	-	-	ko00000,ko03012	-	-	-	eIF-5a
HKD1_k127_7618268_3	436308.Nmar_1501	3.706e-30	123.0	arCOG10586@1|root,arCOG10586@2157|Archaea,41STH@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7618268_1	436308.Nmar_1502	1.936e-117	378.0	arCOG08699@1|root,arCOG08699@2157|Archaea,41S8N@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Ammonia monooxygenase methane monooxygenase, subunit C	-	-	-	ko:K10946	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	AmoC
HKD1_k127_7618268_2	436308.Nmar_1503	1.877e-74	255.0	arCOG08675@1|root,arCOG08675@2157|Archaea,41SI5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Monooxygenase subunit B protein	-	-	-	ko:K10945	ko00680,ko00910,ko01100,ko01120,ko01200,map00680,map00910,map01100,map01120,map01200	M00174,M00528,M00804	R00148,R09518	RC00173,RC02797	ko00000,ko00001,ko00002	-	-	-	Monooxygenase_B
HKD1_k127_7618268_5	1131266.ARWQ01000024_gene145	6.484e-15	80.0	COG3794@1|root,arCOG02926@2157|Archaea	2157|Archaea	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind
HKD1_k127_7618268_4	247490.KSU1_D0671	1.199e-19	98.0	COG3848@1|root,COG3848@2|Bacteria	2|Bacteria	GT	kinase activity	-	-	2.7.3.13,2.7.9.1,2.7.9.2	ko:K01006,ko:K01007,ko:K22424	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173,M00374	R00199,R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1080,PEP-utilizers,PPDK_N
HKD1_k127_7618268_0	1459636.NTE_03344	3.082e-153	499.0	COG0004@1|root,arCOG04397@2157|Archaea,41SY0@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Ammonium Transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD1_k127_7618268_6	1131266.ARWQ01000001_gene1368	3.119e-08	61.0	arCOG08807@1|root,arCOG08807@2157|Archaea,41SRC@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7628818_4	747365.Thena_0019	7.383e-08	58.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,42G8R@68295|Thermoanaerobacterales	186801|Clostridia	NT	PFAM CheC domain protein	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
HKD1_k127_7628818_2	1459636.NTE_02351	6.233e-49	185.0	COG1352@1|root,arCOG04402@2157|Archaea	2157|Archaea	NT	Methylase of chemotaxis methyl-accepting	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD1_k127_7628818_3	1459636.NTE_02346	1.665e-43	162.0	COG0784@1|root,arCOG02391@2157|Archaea,41TB0@651137|Thaumarchaeota	651137|Thaumarchaeota	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_7628818_0	1459636.NTE_02347	6.602e-103	345.0	COG2201@1|root,arCOG02382@2157|Archaea	2157|Archaea	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD1_k127_7628818_1	273068.TTE1417	1.528e-86	300.0	COG0643@1|root,COG2198@1|root,COG0643@2|Bacteria,COG2198@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,42END@68295|Thermoanaerobacterales	186801|Clostridia	T	Signal transducing histidine kinase, homodimeric	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
HKD1_k127_7671759_2	1229909.NSED_00860	2.991e-14	76.0	arCOG08024@1|root,arCOG08024@2157|Archaea,41SRU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_2
HKD1_k127_7671759_1	1229909.NSED_05700	1.143e-42	160.0	COG2236@1|root,arCOG00040@2157|Archaea,41TA1@651137|Thaumarchaeota	651137|Thaumarchaeota	F	phosphoribosyltransferase	-	-	-	ko:K07101	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_7671759_0	999541.bgla_1g08530	1.738e-53	197.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2VKS9@28216|Betaproteobacteria,1K1BQ@119060|Burkholderiaceae	28216|Betaproteobacteria	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD1_k127_7684211_4	436308.Nmar_0775	9.651e-07	52.0	arCOG08712@1|root,arCOG08712@2157|Archaea,41SU6@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7684211_0	436308.Nmar_0774	2.036e-92	310.0	COG0805@1|root,arCOG01919@2157|Archaea,41S69@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD1_k127_7684211_3	1229909.NSED_04300	1.878e-16	80.0	COG1826@1|root,arCOG02694@2157|Archaea,41T8C@651137|Thaumarchaeota	651137|Thaumarchaeota	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_7684211_2	1131266.ARWQ01000002_gene438	4.792e-19	99.0	COG0457@1|root,COG5549@1|root,arCOG03038@2157|Archaea,arCOG04994@2157|Archaea,41T10@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Zinc-dependent metalloprotease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M10,TPR_8
HKD1_k127_7684211_1	436308.Nmar_0770	3.778e-77	261.0	COG1759@1|root,arCOG04346@2157|Archaea,41S79@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Domain of unknown function (DUF1297)	-	-	6.3.4.23	ko:K06863	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R06975	RC00263,RC00323	ko00000,ko00001,ko00002,ko01000	-	-	-	DUF1246,DUF1297
HKD1_k127_7707337_2	1274524.BSONL12_21499	5.16e-27	128.0	COG0739@1|root,COG0741@1|root,COG1196@1|root,COG0739@2|Bacteria,COG0741@2|Bacteria,COG1196@2|Bacteria,1V6DD@1239|Firmicutes,4HIWA@91061|Bacilli,1ZH33@1386|Bacillus	91061|Bacilli	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23,PhageMin_Tail,SLT
HKD1_k127_7707337_1	1274524.BSONL12_21504	1.362e-58	212.0	COG4722@1|root,33P3R@2|Bacteria,1VKWN@1239|Firmicutes,4HRWG@91061|Bacilli,1ZMZE@1386|Bacillus	91061|Bacilli	S	Phage tail protein	-	-	-	-	-	-	-	-	-	-	-	-	Sipho_tail
HKD1_k127_7707337_0	1274524.BSONL12_21509	2.798e-135	452.0	COG2433@1|root,COG2433@2|Bacteria,1V2Z6@1239|Firmicutes,4HGM7@91061|Bacilli,1ZM1W@1386|Bacillus	91061|Bacilli	S	Pfam Transposase IS66	-	-	-	-	-	-	-	-	-	-	-	-	Prophage_tail
HKD1_k127_774815_3	1229909.NSED_07765	2.242e-32	131.0	arCOG08774@1|root,arCOG08774@2157|Archaea,41T7U@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_774815_0	436308.Nmar_1415	6.959e-154	494.0	COG2237@1|root,arCOG04151@2157|Archaea,41SA3@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF373)	-	-	-	ko:K08975	-	-	-	-	ko00000	-	-	-	DUF373
HKD1_k127_774815_1	1131266.ARWQ01000018_gene779	9.05e-125	404.0	COG0020@1|root,arCOG01532@2157|Archaea,41S8J@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids	uppS	-	2.5.1.89	ko:K15888	ko00900,map00900	-	R09730	RC00279,RC02839	ko00000,ko00001,ko01000	-	-	-	Prenyltransf
HKD1_k127_774815_2	1229909.NSED_07780	1.164e-44	165.0	COG0494@1|root,arCOG01078@2157|Archaea,41SPS@651137|Thaumarchaeota	651137|Thaumarchaeota	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_774815_4	1229909.NSED_07785	5.719e-27	111.0	COG0284@1|root,arCOG00081@2157|Archaea,41SMN@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Orotidine 5'-phosphate decarboxylase / HUMPS family	-	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD1_k127_7763380_4	436308.Nmar_0272	1.173e-42	158.0	COG4799@1|root,arCOG02705@2157|Archaea,41SEH@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	2.1.3.15,6.4.1.2,6.4.1.3	ko:K18604	ko00720,ko01120,map00720,map01120	-	R00742,R01859	RC00040,RC00097,RC00367,RC00609	ko00000,ko00001,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_7763380_5	1131266.ARWQ01000032_gene1006	1.459e-13	74.0	arCOG08785@1|root,arCOG08785@2157|Archaea,41SVD@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	ko:K03646	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	-
HKD1_k127_7763380_3	1229909.NSED_01255	1.781e-50	181.0	arCOG08784@1|root,arCOG08784@2157|Archaea,41SVZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7763380_1	1131266.ARWQ01000008_gene344	9.987e-162	517.0	COG0470@1|root,arCOG00470@2157|Archaea,41S9F@651137|Thaumarchaeota	651137|Thaumarchaeota	L	ATPase family associated with various cellular activities (AAA)	-	-	-	ko:K04800	ko03030,map03030	-	-	-	ko00000,ko00001,ko03032	-	-	-	AAA
HKD1_k127_7763380_0	1229909.NSED_01245	1.937e-168	536.0	arCOG08783@1|root,arCOG08783@2157|Archaea,41SFX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7763380_2	1229909.NSED_01240	3.758e-106	350.0	COG0483@1|root,arCOG01349@2157|Archaea,41SIF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Inositol monophosphatase	-	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD1_k127_7790708_0	1131266.ARWQ01000018_gene775	4.472e-155	496.0	COG0104@1|root,arCOG04387@2157|Archaea,41SCA@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_7790708_1	1131266.ARWQ01000018_gene774	2.101e-52	191.0	arCOG08772@1|root,arCOG08772@2157|Archaea,41SSX@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7790708_2	1229909.NSED_07805	2.814e-38	144.0	arCOG10584@1|root,arCOG10584@2157|Archaea,41SV6@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Bacterial Fe(2+) trafficking	-	-	-	-	-	-	-	-	-	-	-	-	Iron_traffic
HKD1_k127_7790708_3	436308.Nmar_1424	1.984e-26	109.0	arCOG08687@1|root,arCOG08687@2157|Archaea,41SVF@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7790708_4	1229909.NSED_07815	8.983e-16	78.0	arCOG08771@1|root,arCOG08771@2157|Archaea,41SNZ@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7829314_0	436308.Nmar_1085	1.079e-217	681.0	COG0458@1|root,arCOG01594@2157|Archaea,41SBF@651137|Thaumarchaeota	651137|Thaumarchaeota	E	MGS-like domain	-	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_7829314_3	436308.Nmar_1084	4.291e-92	308.0	COG1407@1|root,arCOG01150@2157|Archaea,41SJB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Calcineurin-like phosphoesterase	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_7829314_6	436308.Nmar_1083	2.49e-25	108.0	COG5431@1|root,arCOG01120@2157|Archaea,41SW3@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7829314_5	1229909.NSED_06295	1.598e-38	145.0	arCOG08700@1|root,arCOG08700@2157|Archaea,41SV2@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7829314_1	436308.Nmar_1119	2.538e-198	625.0	COG0151@1|root,arCOG04415@2157|Archaea,41SB3@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_7829314_4	436308.Nmar_1118	1.241e-52	191.0	COG0212@1|root,arCOG00474@2157|Archaea,41SRZ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	5-formyltetrahydrofolate cyclo-ligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD1_k127_7829314_2	436308.Nmar_1117	1.446e-132	428.0	COG2759@1|root,arCOG04538@2157|Archaea,41S6B@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_7829314_7	436308.Nmar_1115	7.732e-25	105.0	arCOG03008@1|root,arCOG03008@2157|Archaea,41STF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_7835259_1	1229909.NSED_09600	1.194e-41	154.0	COG0112@1|root,arCOG00070@2157|Archaea,41S7U@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD1_k127_7835259_0	436308.Nmar_1794	0.0	1547.0	COG1933@1|root,arCOG04447@2157|Archaea,41SYW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Possesses two activities a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase	polC	-	2.7.7.7	ko:K02322	ko00230,ko00240,ko01100,ko03030,map00230,map00240,map01100,map03030	M00264	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032	-	-	-	PolC_DP2
HKD1_k127_7844362_3	436308.Nmar_0537	8.433e-51	181.0	COG3635@1|root,arCOG01696@2157|Archaea,41S6M@651137|Thaumarchaeota	651137|Thaumarchaeota	G	phosphoglycerate mutase	-	-	5.4.2.12	ko:K15635	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,PhosphMutase
HKD1_k127_7844362_2	1131266.ARWQ01000005_gene845	6.013e-57	203.0	COG1547@1|root,arCOG03705@2157|Archaea,41SQ0@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Domain of unknown function (DUF309)	-	-	-	ko:K09763	-	-	-	-	ko00000	-	-	-	DUF309
HKD1_k127_7844362_5	436308.Nmar_0535	1.375e-36	141.0	COG2004@1|root,arCOG04182@2157|Archaea,41SWI@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS24 family	-	-	-	ko:K02974	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	-
HKD1_k127_7844362_6	1131266.ARWQ01000005_gene843	2.126e-22	96.0	COG1998@1|root,arCOG04183@2157|Archaea,41SWB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Belongs to the eukaryotic ribosomal protein eS31 family	rps27ae	-	-	ko:K02977	ko03010,map03010	M00177,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko04147	-	-	-	Ribosomal_S27
HKD1_k127_7844362_1	1131266.ARWQ01000005_gene842	2.249e-101	334.0	arCOG08681@1|root,arCOG08681@2157|Archaea,41SH9@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7844362_0	436308.Nmar_0532	3.71e-122	402.0	COG1258@1|root,arCOG01015@2157|Archaea,41SHC@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs	-	-	5.4.99.25	ko:K07583	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	-
HKD1_k127_7844362_4	1229909.NSED_06030	5.644e-40	155.0	COG0484@1|root,COG1141@1|root,arCOG00349@2157|Archaea,arCOG02846@2157|Archaea,41ST0@651137|Thaumarchaeota	651137|Thaumarchaeota	CO	DnaJ-class molecular chaperone with C-terminal Zn finger domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ,Fer4_13
HKD1_k127_7848670_1	436308.Nmar_1316	1.391e-107	359.0	COG0477@1|root,arCOG00130@2157|Archaea,41T0X@651137|Thaumarchaeota	651137|Thaumarchaeota	G	major facilitator superfamily	-	-	-	ko:K08153,ko:K08221	-	M00717	-	-	ko00000,ko00002,ko02000	2.A.1.2.8,2.A.1.32	-	-	MFS_1
HKD1_k127_7848670_2	436308.Nmar_1318	1.692e-25	109.0	COG1826@1|root,arCOG02694@2157|Archaea,41SRR@651137|Thaumarchaeota	651137|Thaumarchaeota	U	mttA/Hcf106 family	-	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD1_k127_7848670_0	374847.Kcr_0087	1.738e-137	446.0	COG0334@1|root,arCOG01352@2157|Archaea	2157|Archaea	C	Belongs to the Glu Leu Phe Val dehydrogenases family	gdhA1	GO:0000166,GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0004354,GO:0005488,GO:0006082,GO:0006103,GO:0006520,GO:0006536,GO:0006807,GO:0008150,GO:0008152,GO:0009064,GO:0009987,GO:0016043,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0022607,GO:0034214,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0043648,GO:0043933,GO:0044085,GO:0044237,GO:0044238,GO:0044281,GO:0048037,GO:0050661,GO:0050662,GO:0051186,GO:0051259,GO:0051287,GO:0055114,GO:0065003,GO:0070401,GO:0070402,GO:0070403,GO:0070404,GO:0071704,GO:0071840,GO:0097159,GO:1901265,GO:1901363,GO:1901564,GO:1901605	1.4.1.2,1.4.1.3,1.4.1.4	ko:K00260,ko:K00261,ko:K00262	ko00220,ko00250,ko00430,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00430,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_7865602_0	436308.Nmar_1303	4.043e-54	191.0	COG0316@1|root,arCOG04560@2157|Archaea,41SKH@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Iron-sulfur cluster assembly accessory protein	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD1_k127_7865602_1	596152.DesU5LDRAFT_3806	1.871e-29	118.0	arCOG05253@1|root,31CTK@2|Bacteria,1RIYS@1224|Proteobacteria,42T7T@68525|delta/epsilon subdivisions,2WP9R@28221|Deltaproteobacteria	28221|Deltaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7865602_3	990285.RGCCGE502_24863	5.531e-10	64.0	COG1814@1|root,COG1814@2|Bacteria,1R469@1224|Proteobacteria,2U4KR@28211|Alphaproteobacteria,4BCYP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	VIT family	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD1_k127_7894114_2	436308.Nmar_1396	1.004e-15	79.0	COG1522@1|root,arCOG04153@2157|Archaea,41SP6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7894114_0	436308.Nmar_1396	1.358e-46	174.0	COG1522@1|root,arCOG04153@2157|Archaea,41SP6@651137|Thaumarchaeota	651137|Thaumarchaeota	K	COG1522 Transcriptional regulators	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7894114_1	1229909.NSED_07575	3.15e-31	128.0	arCOG10583@1|root,arCOG10583@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7895754_3	436308.Nmar_0571	3.707e-27	113.0	arCOG08826@1|root,arCOG08826@2157|Archaea,41T53@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7895754_5	436308.Nmar_1599	2.585e-20	92.0	arCOG08662@1|root,arCOG08662@2157|Archaea,41SQG@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7895754_2	1131266.ARWQ01000001_gene1222	5.464e-50	179.0	COG0139@1|root,arCOG02676@2157|Archaea,41SPE@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HKD1_k127_7895754_4	1089547.KB913013_gene710	3.275e-23	102.0	2CFT1@1|root,32WXV@2|Bacteria,4NTST@976|Bacteroidetes,47X5U@768503|Cytophagia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7895754_0	1459636.NTE_02862	3.429e-143	468.0	arCOG00144@1|root,arCOG00144@2157|Archaea	2157|Archaea	S	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7895754_6	273075.Ta0615	0.0006075	50.0	arCOG03691@1|root,arCOG03691@2157|Archaea,2Y1YV@28890|Euryarchaeota,242AJ@183967|Thermoplasmata	183967|Thermoplasmata	S	amino acid activation for nonribosomal peptide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7929761_0	436308.Nmar_1322	1.064e-162	519.0	COG3569@1|root,arCOG08649@2157|Archaea,41SDH@651137|Thaumarchaeota	651137|Thaumarchaeota	L	DNA Topoisomerase I (eukaryota)	-	-	5.99.1.2	ko:K03163	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topo_C_assoc,Topoisom_I,Topoisom_I_N
HKD1_k127_7932245_0	1229909.NSED_09905	7.97e-119	393.0	COG1293@1|root,arCOG01695@2157|Archaea,41SB0@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Fibronectin-binding protein A N-terminus (FbpA)	-	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_7932245_4	1229909.NSED_09910	1.03e-14	79.0	arCOG10415@1|root,arCOG10415@2157|Archaea,41T6I@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7932245_2	436308.Nmar_0057	1.202e-81	275.0	COG2242@1|root,arCOG00977@2157|Archaea,41SID@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the methylation of C-15 in cobalt-precorrin-6B followed by the decarboxylation of C-12 to form cobalt-precorrin- 7	cbiT	-	2.1.1.196	ko:K02191	ko00860,map00860	-	R05813,R07774	RC00003,RC02052,RC02054	ko00000,ko00001,ko01000	-	-	-	Methyltransf_31
HKD1_k127_7932245_1	436308.Nmar_0058	7.402e-104	342.0	COG2243@1|root,arCOG00648@2157|Archaea,41SGJ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_7932245_3	1229909.NSED_09925	7.855e-47	170.0	COG2875@1|root,arCOG00645@2157|Archaea,41SE7@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Tetrapyrrole (Corrin/Porphyrin) Methylases	-	-	2.1.1.133,2.1.1.271	ko:K05936	ko00860,ko01100,map00860,map01100	-	R05181,R05810	RC00003,RC01294,RC02049	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_7938447_1	1229909.NSED_01910	2.087e-142	459.0	COG0552@1|root,arCOG01227@2157|Archaea,41SCC@651137|Thaumarchaeota	651137|Thaumarchaeota	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD1_k127_7938447_3	1229909.NSED_01905	2.929e-37	144.0	COG1730@1|root,arCOG01341@2157|Archaea,41SSP@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding	pfdA	-	-	ko:K04797	-	-	-	-	ko00000,ko03110	-	-	-	Prefoldin
HKD1_k127_7938447_2	1131266.ARWQ01000028_gene1020	1.185e-101	334.0	COG0605@1|root,arCOG04147@2157|Archaea,41S6C@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD1_k127_7938447_0	1229909.NSED_01895	9.372e-189	610.0	COG1404@1|root,arCOG00702@2157|Archaea,41SX3@651137|Thaumarchaeota	651137|Thaumarchaeota	O	Belongs to the peptidase S8 family	-	-	-	ko:K14647	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000,ko01002,ko03110	-	-	-	PA,Peptidase_S8
HKD1_k127_7938447_4	436308.Nmar_0392	1.998e-10	61.0	COG1866@1|root,arCOG06073@2157|Archaea,41SE5@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD1_k127_7967344_6	1151117.AJLF01000002_gene240	6.36e-55	195.0	COG1156@1|root,arCOG00865@2157|Archaea,2XSYQ@28890|Euryarchaeota,2433N@183968|Thermococci	183968|Thermococci	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_7967344_8	273075.Ta0006	5.033e-41	160.0	COG1394@1|root,arCOG04101@2157|Archaea,2XTQ5@28890|Euryarchaeota,241TN@183967|Thermoplasmata	183967|Thermoplasmata	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD1_k127_7967344_0	1131266.ARWQ01000024_gene138	7.717e-237	749.0	COG1269@1|root,arCOG04138@2157|Archaea,41SRH@651137|Thaumarchaeota	651137|Thaumarchaeota	C	Belongs to the V-ATPase 116 kDa subunit family	-	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_7967344_5	436308.Nmar_1687	5.313e-70	246.0	COG1781@1|root,arCOG04229@2157|Archaea,41SJT@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Involved in allosteric regulation of aspartate carbamoyltransferase	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
HKD1_k127_7967344_1	1229909.NSED_08980	2.179e-145	467.0	COG0540@1|root,arCOG00911@2157|Archaea,41S6H@651137|Thaumarchaeota	651137|Thaumarchaeota	F	aspartate carbamoyltransferase	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD1_k127_7967344_7	436308.Nmar_1656	2.905e-51	184.0	COG0864@1|root,arCOG01008@2157|Archaea,41SQM@651137|Thaumarchaeota	651137|Thaumarchaeota	K	Ribbon-helix-helix protein, copG family	-	-	-	ko:K07722	-	-	-	-	ko00000,ko03000	-	-	-	NikR_C,RHH_1
HKD1_k127_7967344_4	1229909.NSED_08960	1.16e-90	307.0	COG0803@1|root,arCOG01005@2157|Archaea,41T29@651137|Thaumarchaeota	651137|Thaumarchaeota	P	Periplasmic solute binding protein	-	-	-	ko:K09815	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ZnuA
HKD1_k127_7967344_2	1229909.NSED_08955	1.16e-103	342.0	COG1121@1|root,arCOG00201@2157|Archaea,41S7E@651137|Thaumarchaeota	651137|Thaumarchaeota	E	PFAM ABC transporter	-	-	-	ko:K09817	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC_tran
HKD1_k127_7967344_3	436308.Nmar_1653	5.959e-98	328.0	COG1108@1|root,arCOG01006@2157|Archaea,41SG2@651137|Thaumarchaeota	651137|Thaumarchaeota	P	ABC 3 transport family	-	-	-	ko:K09816	ko02010,map02010	M00242	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.15.3,3.A.1.15.5	-	-	ABC-3
HKD1_k127_7974675_14	1229909.NSED_09525	8.131e-09	66.0	arCOG08685@1|root,arCOG08685@2157|Archaea	2157|Archaea	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7974675_10	436308.Nmar_1779	9.752e-35	137.0	COG1931@1|root,arCOG01043@2157|Archaea,41SRJ@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Belongs to the UPF0201 family	-	-	-	ko:K09736	-	-	-	-	ko00000	-	-	-	RNA_binding
HKD1_k127_7974675_5	436308.Nmar_1780	3.376e-69	240.0	COG0237@1|root,arCOG01045@2157|Archaea,41SI8@651137|Thaumarchaeota	651137|Thaumarchaeota	H	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_17
HKD1_k127_7974675_8	1131266.ARWQ01000001_gene1353	1.393e-52	190.0	COG1514@1|root,arCOG01736@2157|Archaea,41SP7@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD1_k127_7974675_2	1131266.ARWQ01000001_gene1355	9.892e-142	462.0	COG1746@1|root,arCOG04249@2157|Archaea,41S76@651137|Thaumarchaeota	651137|Thaumarchaeota	J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate	cca	-	2.7.7.72	ko:K07558	-	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko01000,ko03016	-	-	-	NTP_transf_2,tRNA_NucTransf2
HKD1_k127_7974675_9	1459636.NTE_03047	1.315e-49	186.0	COG2112@1|root,arCOG01182@2157|Archaea,41SJV@651137|Thaumarchaeota	651137|Thaumarchaeota	T	Ser thr protein kinase	-	-	-	ko:K07176	-	-	-	-	ko00000	-	-	-	RIO1
HKD1_k127_7974675_1	1229909.NSED_01595	6.139e-154	498.0	COG0053@1|root,arCOG01474@2157|Archaea,41SXN@651137|Thaumarchaeota	651137|Thaumarchaeota	P	cation diffusion facilitator family transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD1_k127_7974675_7	1459636.NTE_03049	2.799e-53	194.0	COG0122@1|root,arCOG00464@2157|Archaea	2157|Archaea	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	alkA	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_7974675_0	436308.Nmar_0888	9.163e-178	573.0	COG1199@1|root,arCOG00770@2157|Archaea,41T2V@651137|Thaumarchaeota	651137|Thaumarchaeota	K	HELICc2	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C_2
HKD1_k127_7974675_3	436308.Nmar_1785	6.319e-134	436.0	COG0446@1|root,arCOG01064@2157|Archaea,41SZR@651137|Thaumarchaeota	651137|Thaumarchaeota	S	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_7974675_4	1131266.ARWQ01000001_gene1357	5.356e-109	357.0	COG4221@1|root,arCOG01265@2157|Archaea,41S66@651137|Thaumarchaeota	651137|Thaumarchaeota	I	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD1_k127_7974675_12	1229909.NSED_09570	3.124e-27	112.0	COG3582@1|root,arCOG01769@2157|Archaea,41SUB@651137|Thaumarchaeota	651137|Thaumarchaeota	S	zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-AN1
HKD1_k127_7974675_13	1131266.ARWQ01000001_gene1359	3.436e-15	78.0	arCOG08809@1|root,arCOG08809@2157|Archaea,41TAB@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7974675_6	1229909.NSED_09580	1.103e-59	211.0	COG1711@1|root,arCOG00551@2157|Archaea,41SVQ@651137|Thaumarchaeota	651137|Thaumarchaeota	L	protein conserved in archaea	-	-	-	ko:K09723	-	-	-	-	ko00000,ko03032	-	-	-	-
HKD1_k127_7974987_0	439235.Dalk_3969	1.719e-59	227.0	COG3170@1|root,COG3170@2|Bacteria,1N4R0@1224|Proteobacteria,42QKG@68525|delta/epsilon subdivisions,2WMF1@28221|Deltaproteobacteria,2MP7B@213118|Desulfobacterales	28221|Deltaproteobacteria	NU	Tfp pilus assembly protein FimV	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8008568_1	1459636.NTE_01783	3.237e-47	171.0	COG0129@1|root,arCOG04045@2157|Archaea,41SD0@651137|Thaumarchaeota	651137|Thaumarchaeota	E	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_8008568_0	436308.Nmar_0911	1.066e-100	334.0	COG0147@1|root,arCOG02014@2157|Archaea,41S8W@651137|Thaumarchaeota	651137|Thaumarchaeota	E	component I	-	-	4.1.3.27	ko:K01657	ko00400,ko00405,ko01100,ko01110,ko01130,ko01230,ko02024,ko02025,map00400,map00405,map01100,map01110,map01130,map01230,map02024,map02025	M00023	R00985,R00986	RC00010,RC02148,RC02414	ko00000,ko00001,ko00002,ko01000	-	-	-	Anth_synt_I_N,Chorismate_bind
HKD1_k127_8021186_0	1131266.ARWQ01000002_gene536	8.824e-111	364.0	COG0026@1|root,arCOG01597@2157|Archaea,41SD9@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD1_k127_8021186_2	1229909.NSED_04670	2.856e-05	46.0	COG0041@1|root,arCOG02464@2157|Archaea,41SN4@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_8037012_0	436308.Nmar_1795	6.465e-76	258.0	COG1646@1|root,arCOG01085@2157|Archaea,41SH4@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids	-	-	2.5.1.41	ko:K17104	ko00564,map00564	-	R04158	RC01091	ko00000,ko00001,ko01000	-	-	-	PcrB
HKD1_k127_8037012_1	436308.Nmar_1796	2.381e-42	158.0	arCOG08806@1|root,arCOG08806@2157|Archaea,41SUU@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_8037012_2	436308.Nmar_1797	1.482e-37	147.0	arCOG08041@1|root,arCOG08041@2157|Archaea,41SRT@651137|Thaumarchaeota	651137|Thaumarchaeota	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
HKD1_k127_8037012_3	1229909.NSED_09630	1.039e-12	68.0	arCOG00818@1|root,arCOG00818@2157|Archaea	2157|Archaea	S	AbrB family	-	-	-	-	-	-	-	-	-	-	-	-	MazE_antitoxin
HKD1_k127_831364_0	399739.Pmen_4121	1.026e-13	79.0	COG2905@1|root,COG2905@2|Bacteria,1QTTR@1224|Proteobacteria,1T1K1@1236|Gammaproteobacteria,1YJHF@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	T	Domain in cystathionine beta-synthase and other proteins.	hrp1	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD1_k127_861186_3	1229909.NSED_06455	1.387e-07	57.0	COG1236@1|root,arCOG00545@2157|Archaea,41SYB@651137|Thaumarchaeota	651137|Thaumarchaeota	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_861186_2	436308.Nmar_1073	2.055e-08	63.0	COG3794@1|root,arCOG05978@1|root,arCOG07813@1|root,arCOG02926@2157|Archaea,arCOG05978@2157|Archaea,arCOG07813@2157|Archaea	2157|Archaea	C	LamG domain protein jellyroll fold domain protein	-	-	2.7.11.1	ko:K12567	ko05410,ko05414,map05410,map05414	-	-	-	ko00000,ko00001,ko01000,ko01001,ko04131,ko04147,ko04812	-	-	-	Copper-bind,GSDH,Laminin_G_3,ThuA,fn3
HKD1_k127_861186_0	436308.Nmar_1114	1.458e-83	281.0	COG0299@1|root,arCOG02825@2157|Archaea,41SH3@651137|Thaumarchaeota	651137|Thaumarchaeota	F	phosphoribosylglycinamide formyltransferase	-	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N
HKD1_k127_861186_1	436308.Nmar_1115	3.369e-20	91.0	arCOG03008@1|root,arCOG03008@2157|Archaea,41STF@651137|Thaumarchaeota	651137|Thaumarchaeota	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_932617_2	1229909.NSED_00020	2.637e-57	206.0	COG2219@1|root,arCOG03013@2157|Archaea,41SCD@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair	priL	-	-	ko:K18882	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DNA_primase_lrg
HKD1_k127_932617_0	1229909.NSED_00015	4.145e-123	400.0	COG0648@1|root,arCOG01894@2157|Archaea,41SDW@651137|Thaumarchaeota	651137|Thaumarchaeota	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_932617_1	1131266.ARWQ01000001_gene1294	1.763e-62	217.0	COG0423@1|root,arCOG00405@2157|Archaea,41S8S@651137|Thaumarchaeota	651137|Thaumarchaeota	J	synthetase (class II)	-	-	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD1_k127_950534_0	1459636.NTE_00051	2.808e-67	231.0	COG0125@1|root,arCOG01891@2157|Archaea	2157|Archaea	F	thymidylate kinase	-	GO:0003674,GO:0003824,GO:0004798,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006220,GO:0006221,GO:0006227,GO:0006233,GO:0006235,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009041,GO:0009058,GO:0009117,GO:0009123,GO:0009132,GO:0009133,GO:0009138,GO:0009139,GO:0009141,GO:0009142,GO:0009147,GO:0009148,GO:0009165,GO:0009186,GO:0009189,GO:0009196,GO:0009197,GO:0009200,GO:0009202,GO:0009211,GO:0009212,GO:0009219,GO:0009221,GO:0009262,GO:0009263,GO:0009265,GO:0009394,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019692,GO:0034641,GO:0034654,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044424,GO:0044464,GO:0046072,GO:0046075,GO:0046077,GO:0046385,GO:0046483,GO:0046940,GO:0050145,GO:0055086,GO:0071704,GO:0072527,GO:0072528,GO:0090407,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_950534_1	1459636.NTE_00049	7.061e-42	159.0	COG2062@1|root,arCOG01992@2157|Archaea	2157|Archaea	T	TIGRFAM phosphohistidine phosphatase SixA	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD1_k127_950534_2	1459636.NTE_00050	1.493e-28	117.0	COG0248@1|root,arCOG05138@2157|Archaea	2157|Archaea	FP	PFAM Ppx GppA phosphatase	ppx	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	HD,Ppx-GppA
HKD1_k127_95514_0	1229909.NSED_06180	1.094e-56	209.0	COG0642@1|root,arCOG02358@2157|Archaea	2157|Archaea	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE4,HAMP,HATPase_c,HisKA,PAS_4,PAS_8,PAS_9,Response_reg,sCache_3_3
HKD1_k127_95514_1	436308.Nmar_0707	1.551e-07	58.0	COG2201@1|root,arCOG02382@2157|Archaea	2157|Archaea	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412,ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD1_k127_957288_5	1229909.NSED_08735	3.129e-46	169.0	COG2429@1|root,arCOG04202@2157|Archaea,41SHK@651137|Thaumarchaeota	651137|Thaumarchaeota	F	Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity	gch3	-	3.5.4.29	ko:K08096	ko00740,ko01100,map00740,map01100	-	R07306	RC01790	ko00000,ko00001,ko01000	-	-	-	GCH_III
HKD1_k127_957288_4	1131266.ARWQ01000009_gene933	2.06e-54	194.0	COG0054@1|root,arCOG01323@2157|Archaea,41SQ6@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_957288_2	1229909.NSED_08745	4.279e-90	301.0	COG0108@1|root,arCOG01320@2157|Archaea,41SFW@651137|Thaumarchaeota	651137|Thaumarchaeota	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	-	-	4.1.99.12	ko:K02858	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R07281	RC01792,RC01815	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase
HKD1_k127_957288_3	436308.Nmar_1617	5.898e-78	266.0	COG0307@1|root,arCOG04713@2157|Archaea,41SKQ@651137|Thaumarchaeota	651137|Thaumarchaeota	H	riboflavin synthase, alpha	-	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD1_k127_957288_0	436308.Nmar_1621	1.147e-115	378.0	COG2301@1|root,arCOG00760@2157|Archaea,41S6F@651137|Thaumarchaeota	651137|Thaumarchaeota	G	HpcH/HpaI aldolase/citrate lyase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD1_k127_957288_1	1229909.NSED_08780	1.583e-102	335.0	COG0604@1|root,arCOG01458@2157|Archaea,41SZ9@651137|Thaumarchaeota	651137|Thaumarchaeota	C	PFAM Alcohol dehydrogenase GroES-like domain	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N
## 1125 queries scanned
## Total time (seconds): 9.185301065444946
## Rate: 122.48 q/s