## Tue Feb 17 06:46:03 2026
## emapper-2.1.13
## /data/anaconda3/envs/eggnog-mapper/bin/emapper.py -i /data/result/bins/wyx/bins/HKD1_bin.90.fa -m mmseqs --output HKD1_bin.90 --output_dir /data/result/bins/wyx/eggqs50+/HKD1_bin.90 --itype genome --cpu 8 --override
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD1_k127_101037_0	509191.AEDB02000018_gene292	2.037e-111	370.0	COG1621@1|root,COG2247@1|root,COG1621@2|Bacteria,COG2247@2|Bacteria,1V7X5@1239|Firmicutes,25G2M@186801|Clostridia	186801|Clostridia	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_1016258_1	1123009.AUID01000010_gene547	3.153e-178	561.0	COG1063@1|root,COG1063@2|Bacteria,1TS6I@1239|Firmicutes,25B0S@186801|Clostridia,26CNX@186813|unclassified Clostridiales	186801|Clostridia	E	Zinc-binding dehydrogenase	tdh	-	1.1.1.103	ko:K00060	ko00260,map00260	-	R01465	RC00525	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD1_k127_1016258_0	1123009.AUID01000010_gene548	4.069e-205	643.0	COG0156@1|root,COG0156@2|Bacteria,1TPUX@1239|Firmicutes,2491D@186801|Clostridia,26A5B@186813|unclassified Clostridiales	186801|Clostridia	H	Aminotransferase class I and II	kbl	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006732,GO:0006766,GO:0006767,GO:0006768,GO:0006790,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0008710,GO:0008890,GO:0009058,GO:0009102,GO:0009108,GO:0009110,GO:0009987,GO:0016053,GO:0016407,GO:0016408,GO:0016453,GO:0016740,GO:0016746,GO:0016747,GO:0017144,GO:0018130,GO:0019752,GO:0019842,GO:0030170,GO:0032787,GO:0034641,GO:0036094,GO:0042364,GO:0043167,GO:0043168,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044249,GO:0044271,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0046483,GO:0048037,GO:0050662,GO:0051186,GO:0051188,GO:0070279,GO:0071704,GO:0072330,GO:0097159,GO:1901360,GO:1901362,GO:1901363,GO:1901564,GO:1901566,GO:1901576	2.3.1.29	ko:K00639	ko00260,map00260	-	R00371	RC00004,RC00394	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1016258_2	1511.CLOST_1076	3.831e-15	81.0	2C1YE@1|root,330PN@2|Bacteria,1VHRZ@1239|Firmicutes,24M1A@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_102091_1	1120746.CCNL01000011_gene1494	1.476e-76	269.0	COG1315@1|root,COG1315@2|Bacteria,2NRDR@2323|unclassified Bacteria	2|Bacteria	L	Pfam:DUF342	-	-	-	ko:K09749	-	-	-	-	ko00000	-	-	-	FapA
HKD1_k127_102091_4	1123009.AUID01000010_gene601	1.238e-41	161.0	COG4786@1|root,COG4786@2|Bacteria,1TT5Z@1239|Firmicutes,248M9@186801|Clostridia,26998@186813|unclassified Clostridiales	186801|Clostridia	N	Flagellar basal body rod FlgEFG protein C-terminal	flgG	-	-	ko:K02390,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD1_k127_102091_2	1120746.CCNL01000011_gene1492	4.352e-65	230.0	COG4786@1|root,COG4786@2|Bacteria,2NPX1@2323|unclassified Bacteria	2|Bacteria	N	Flagella basal body rod protein	flhO	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02388,ko:K02391,ko:K02392	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD1_k127_102091_3	1120746.CCNL01000011_gene1491	5.803e-49	181.0	COG1191@1|root,COG1191@2|Bacteria,2NPMN@2323|unclassified Bacteria	2|Bacteria	K	Sigma-70 region 3	fliA	-	-	ko:K02405	ko02020,ko02025,ko02026,ko02040,ko05111,map02020,map02025,map02026,map02040,map05111	-	-	-	ko00000,ko00001,ko02035,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_102091_5	1121335.Clst_2308	0.0003688	44.0	COG1191@1|root,COG1191@2|Bacteria,1TP3Q@1239|Firmicutes,2487Z@186801|Clostridia,3WHMZ@541000|Ruminococcaceae	186801|Clostridia	K	RNA polymerase sigma-70 factor, sigma-B F G subfamily	sigB	-	-	ko:K03090,ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_102091_0	1120746.CCNL01000011_gene1490	8.785e-179	568.0	COG1298@1|root,COG1298@2|Bacteria,2NNK8@2323|unclassified Bacteria	2|Bacteria	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
HKD1_k127_1031673_0	1128398.Curi_c28300	2.683e-125	409.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,267K0@186813|unclassified Clostridiales	186801|Clostridia	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_1038851_0	610130.Closa_1802	5.773e-78	273.0	COG2515@1|root,COG2515@2|Bacteria,1UDCW@1239|Firmicutes,24BXZ@186801|Clostridia,220EC@1506553|Lachnoclostridium	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
HKD1_k127_104729_0	180332.JTGN01000012_gene406	1.734e-207	648.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_104729_1	1123075.AUDP01000008_gene1752	3.397e-102	337.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,3WGVP@541000|Ruminococcaceae	186801|Clostridia	V	ABC-type multidrug transport system ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_104729_2	180332.JTGN01000012_gene405	1.599e-34	133.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia	186801|Clostridia	V	Abc transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1049112_0	332101.JIBU02000051_gene3433	5.722e-149	479.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36GQP@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_1050533_0	720554.Clocl_2556	1.242e-27	121.0	COG4905@1|root,COG4905@2|Bacteria,1V2HX@1239|Firmicutes,24B3D@186801|Clostridia	186801|Clostridia	D	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
HKD1_k127_1073735_2	903814.ELI_1202	3.866e-17	83.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,25UWB@186806|Eubacteriaceae	186801|Clostridia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_1073735_1	1304284.L21TH_1808	1.194e-75	259.0	COG0299@1|root,COG0299@2|Bacteria,1V3RJ@1239|Firmicutes,249JC@186801|Clostridia,36I7J@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04225	Formyl_trans_N
HKD1_k127_1073735_0	1291050.JAGE01000001_gene339	7.65e-175	553.0	COG0138@1|root,COG0138@2|Bacteria,1TPQ5@1239|Firmicutes,24AB8@186801|Clostridia,3WHMW@541000|Ruminococcaceae	186801|Clostridia	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS04230	AICARFT_IMPCHas,MGS
HKD1_k127_1074754_0	1243664.CAVL020000010_gene4509	1.982e-190	608.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,4H9XI@91061|Bacilli,1ZCRF@1386|Bacillus	91061|Bacilli	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	iYO844.BSU30940	Phosphorylase
HKD1_k127_1076827_1	1230342.CTM_14003	3.78e-48	178.0	2F9R0@1|root,34213@2|Bacteria,1UTDI@1239|Firmicutes,252I7@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF1444)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1444
HKD1_k127_1076827_0	1469948.JPNB01000001_gene819	2.496e-139	449.0	COG2723@1|root,COG2723@2|Bacteria,1TP19@1239|Firmicutes,2485V@186801|Clostridia,36DZU@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycosyl hydrolase 1 family	-	-	3.2.1.21	ko:K05350	ko00460,ko00500,ko00940,ko01100,ko01110,map00460,map00500,map00940,map01100,map01110	-	R00026,R02558,R02887,R02985,R03527,R04949,R04998,R10035,R10039,R10040	RC00049,RC00059,RC00171,RC00262,RC00397,RC00451,RC00714,RC00746,RC01248	ko00000,ko00001,ko01000	-	-	-	Glyco_hydro_1
HKD1_k127_1077374_1	865861.AZSU01000010_gene736	9.977e-43	158.0	COG1066@1|root,COG1066@2|Bacteria,1TQ7Y@1239|Firmicutes,247TA@186801|Clostridia,36DMV@31979|Clostridiaceae	186801|Clostridia	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI,Lon_C
HKD1_k127_1077374_0	1121289.JHVL01000011_gene1402	1.494e-202	639.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,36UI3@31979|Clostridiaceae	186801|Clostridia	C	carboxyltransferase	pycB	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HKD1_k127_108107_1	1151292.QEW_1969	4.855e-19	87.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,25SNM@186804|Peptostreptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_108107_0	1410653.JHVC01000024_gene1131	9.904e-87	291.0	COG0139@1|root,COG0140@1|root,COG0139@2|Bacteria,COG0140@2|Bacteria,1UYNA@1239|Firmicutes,247RS@186801|Clostridia,36JI7@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19,3.6.1.31	ko:K01496,ko:K11755	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04035,R04037	RC00002,RC01055	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS05760	His_biosynth,PRA-CH,PRA-PH
HKD1_k127_1084789_0	1304880.JAGB01000003_gene1295	3.08e-184	582.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	GDC-P
HKD1_k127_108676_7	1347392.CCEZ01000043_gene245	2.731e-43	162.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,36J5P@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	iscR	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_108676_2	1304284.L21TH_2004	3.906e-163	521.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,36DXY@31979|Clostridiaceae	186801|Clostridia	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_108676_4	1121289.JHVL01000005_gene1017	5.406e-59	209.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,36I0X@31979|Clostridiaceae	186801|Clostridia	C	FeS cluster assembly scaffold protein NifU	nifU	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_108676_0	1304284.L21TH_1998	0.0	1026.0	COG0013@1|root,COG0013@2|Bacteria,1TPK6@1239|Firmicutes,248M3@186801|Clostridia,36E03@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_108676_8	1304284.L21TH_1997	3.174e-29	118.0	COG4472@1|root,COG4472@2|Bacteria,1VAC4@1239|Firmicutes,24QVQ@186801|Clostridia,36KEY@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0297 family	yrzL	-	-	-	-	-	-	-	-	-	-	-	DUF965
HKD1_k127_108676_3	1304284.L21TH_1995	1.219e-97	328.0	COG0667@1|root,COG1145@1|root,COG0667@2|Bacteria,COG1145@2|Bacteria,1UHXA@1239|Firmicutes,25E68@186801|Clostridia,36UUU@31979|Clostridiaceae	186801|Clostridia	C	Aldo/keto reductase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4
HKD1_k127_108676_6	1121289.JHVL01000005_gene1008	9.106e-47	173.0	COG0816@1|root,COG0816@2|Bacteria,1V6ER@1239|Firmicutes,24JGP@186801|Clostridia,36IV4@31979|Clostridiaceae	186801|Clostridia	J	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	yrrK	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD1_k127_108676_9	1304284.L21TH_1993	1.79e-08	59.0	COG3906@1|root,COG3906@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF1292)	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	DUF1292
HKD1_k127_108676_5	1121289.JHVL01000005_gene1005	8.618e-52	187.0	COG0735@1|root,COG0735@2|Bacteria,1V7F0@1239|Firmicutes,24JQE@186801|Clostridia,36I3W@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_108676_1	1304284.L21TH_1990	2.23e-244	766.0	COG0595@1|root,COG0595@2|Bacteria,1TQ9G@1239|Firmicutes,2488J@186801|Clostridia,36DE5@31979|Clostridiaceae	186801|Clostridia	S	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay	rnj	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,RMMBL
HKD1_k127_1088280_0	411467.BACCAP_04294	4.21e-169	535.0	COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia,26APB@186813|unclassified Clostridiales	186801|Clostridia	G	Glycerate kinase family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD1_k127_1088412_0	350688.Clos_1264	3.997e-73	253.0	2AHVT@1|root,3188J@2|Bacteria,1V8V5@1239|Firmicutes,24FT6@186801|Clostridia,36IAB@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1098898_1	1121342.AUCO01000005_gene322	3.581e-13	74.0	COG0491@1|root,COG0491@2|Bacteria,1TT3D@1239|Firmicutes,24BV1@186801|Clostridia,36GFA@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_1098898_0	1123248.KB893314_gene3410	9.311e-166	533.0	COG0513@1|root,COG0513@2|Bacteria,4NEVI@976|Bacteroidetes,1INY6@117747|Sphingobacteriia	976|Bacteroidetes	L	Belongs to the DEAD box helicase family	rhlE	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_1100141_0	290402.Cbei_4481	7.813e-86	293.0	COG0426@1|root,COG1251@1|root,COG0426@2|Bacteria,COG1251@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae	186801|Clostridia	C	flavodoxin nitric oxide synthase	fprA2	GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005506,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0010181,GO:0016491,GO:0016651,GO:0016661,GO:0016662,GO:0016966,GO:0022900,GO:0032553,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0044237,GO:0046872,GO:0046914,GO:0048037,GO:0050662,GO:0050664,GO:0055114,GO:0072593,GO:0097159,GO:0097367,GO:1901265,GO:1901363	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B,Pyr_redox_2
HKD1_k127_110581_0	1304284.L21TH_1088	1.811e-55	211.0	COG5401@1|root,COG5401@2|Bacteria,1VWMY@1239|Firmicutes,251X0@186801|Clostridia,36S1V@31979|Clostridiaceae	186801|Clostridia	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HKD1_k127_110581_1	755731.Clo1100_3827	2.652e-30	124.0	COG4416@1|root,COG4416@2|Bacteria,1VEMD@1239|Firmicutes,24MRR@186801|Clostridia,36KSJ@31979|Clostridiaceae	186801|Clostridia	S	COG NOG18757 non supervised orthologous group	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1120321_1	742740.HMPREF9474_03937	1.051e-21	96.0	COG3404@1|root,COG3404@2|Bacteria,1VVEM@1239|Firmicutes,24JAH@186801|Clostridia	186801|Clostridia	E	Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
HKD1_k127_1120321_0	1105031.HMPREF1141_2736	6.382e-115	376.0	COG1228@1|root,COG1228@2|Bacteria,1TVY2@1239|Firmicutes,24D7Q@186801|Clostridia,36H8R@31979|Clostridiaceae	186801|Clostridia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_1121606_0	1203606.HMPREF1526_02213	3.442e-72	256.0	COG4632@1|root,COG4632@2|Bacteria,1TP2R@1239|Firmicutes,249PA@186801|Clostridia,36JWS@31979|Clostridiaceae	186801|Clostridia	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD1_k127_112260_0	1410668.JNKC01000010_gene966	3.288e-188	591.0	COG4865@1|root,COG4865@2|Bacteria,1TS6B@1239|Firmicutes,24AYE@186801|Clostridia,36FJ9@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	glmE	-	5.4.99.1	ko:K19268	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_asp_mut_E
HKD1_k127_112260_1	1410668.JNKC01000010_gene967	8.179e-48	175.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,36ER4@31979|Clostridiaceae	186801|Clostridia	D	MutL protein	mutL2	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD1_k127_1126854_2	1128398.Curi_c13190	2.949e-27	114.0	COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,2694V@186813|unclassified Clostridiales	186801|Clostridia	U	SEC-C motif	secA_2	-	-	-	-	-	-	-	-	-	-	-	SEC-C
HKD1_k127_1126854_1	1123009.AUID01000003_gene1902	1.538e-47	174.0	COG1970@1|root,COG1970@2|Bacteria,1VA14@1239|Firmicutes,24JAB@186801|Clostridia,269KW@186813|unclassified Clostridiales	186801|Clostridia	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD1_k127_1126854_0	1304284.L21TH_2677	5.415e-65	240.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,24AWX@186801|Clostridia	186801|Clostridia	G	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Metallophos,NAGPA,Pur_ac_phosph_N,SLH
HKD1_k127_112924_0	1301100.HG529274_gene1757	2.922e-154	505.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS_4,PAS_8,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_112924_1	1105031.HMPREF1141_2736	9.673e-50	182.0	COG1228@1|root,COG1228@2|Bacteria,1TVY2@1239|Firmicutes,24D7Q@186801|Clostridia,36H8R@31979|Clostridiaceae	186801|Clostridia	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_1129461_2	1304284.L21TH_2546	2.313e-64	229.0	COG1847@1|root,COG1847@2|Bacteria,1V3IN@1239|Firmicutes,249EA@186801|Clostridia,36F11@31979|Clostridiaceae	186801|Clostridia	S	R3H domain protein	jag	-	-	ko:K06346	-	-	-	-	ko00000	-	-	-	Jag_N,KH_4,R3H
HKD1_k127_1129461_1	1304284.L21TH_2547	1.761e-81	278.0	COG0706@1|root,COG0706@2|Bacteria,1TQ0J@1239|Firmicutes,247V9@186801|Clostridia,36FE7@31979|Clostridiaceae	186801|Clostridia	U	Membrane protein insertase, YidC Oxa1 family	oxaA	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP
HKD1_k127_1129461_3	1321814.HMPREF9089_00747	5.675e-26	108.0	COG0759@1|root,COG0759@2|Bacteria,1VEIG@1239|Firmicutes,24QN4@186801|Clostridia,25XH9@186806|Eubacteriaceae	186801|Clostridia	S	Could be involved in insertion of integral membrane proteins into the membrane	yidD	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD1_k127_1129461_4	1304284.L21TH_2549	1.16e-22	100.0	COG0594@1|root,COG0594@2|Bacteria,1VA78@1239|Firmicutes,24QK5@186801|Clostridia,36KHY@31979|Clostridiaceae	186801|Clostridia	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD1_k127_1129461_5	938288.HG326229_gene63	2.031e-12	69.0	COG0230@1|root,COG0230@2|Bacteria,1VK90@1239|Firmicutes,24UGN@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL34 family	rpmH	-	-	ko:K02914	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L34
HKD1_k127_1129461_0	1443125.Z962_07010	1.643e-171	548.0	COG0593@1|root,COG0593@2|Bacteria,1TPV7@1239|Firmicutes,2490S@186801|Clostridia,36DSQ@31979|Clostridiaceae	186801|Clostridia	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD1_k127_1131038_1	2325.TKV_c18670	3.932e-26	108.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,42GMY@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD1_k127_1131038_0	290402.Cbei_1991	1.425e-68	235.0	COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,36IV7@31979|Clostridiaceae	186801|Clostridia	H	MOSC domain	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD1_k127_1131038_2	1464048.JNZS01000036_gene1990	4.384e-06	54.0	COG5496@1|root,COG5496@2|Bacteria,2IKZP@201174|Actinobacteria,4DE8F@85008|Micromonosporales	201174|Actinobacteria	S	Thioesterase superfamily protein	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_1131038_3	1280688.AUJB01000002_gene2012	9.822e-05	47.0	COG1055@1|root,COG1055@2|Bacteria,1TQCH@1239|Firmicutes,25CD7@186801|Clostridia	186801|Clostridia	P	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD1_k127_1146541_0	767817.Desgi_3825	4.025e-66	233.0	COG0500@1|root,COG2226@2|Bacteria,1V6G6@1239|Firmicutes,24H8Z@186801|Clostridia	186801|Clostridia	Q	PFAM methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD1_k127_1146541_2	293826.Amet_3464	1.842e-60	213.0	COG4807@1|root,COG4807@2|Bacteria,1V4DA@1239|Firmicutes,24GGR@186801|Clostridia,36JA1@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1456)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1456
HKD1_k127_1146541_1	768706.Desor_0696	9.376e-61	214.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia	186801|Clostridia	V	Abc transporter	yfiB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_1162431_0	1232449.BAHV02000016_gene1822	9.363e-149	488.0	28N6S@1|root,2ZBBK@2|Bacteria,1V2EC@1239|Firmicutes,24GN6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1162431_4	1540257.JQMW01000009_gene3370	1.51e-26	111.0	2EF94@1|root,33920@2|Bacteria,1VIXN@1239|Firmicutes,24R4A@186801|Clostridia,36T23@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1162431_1	1232449.BAHV02000016_gene1819	1.739e-100	334.0	28JC4@1|root,2Z96S@2|Bacteria,1TS1K@1239|Firmicutes,249Q6@186801|Clostridia	186801|Clostridia	S	P22 coat protein-protein 5 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	P22_CoatProtein
HKD1_k127_1162431_2	693746.OBV_23870	7.803e-60	218.0	28PXR@1|root,2ZCHM@2|Bacteria,1V24G@1239|Firmicutes,24G17@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1169160_0	1123009.AUID01000001_gene1006	3.223e-170	538.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,2687P@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_1170485_0	332101.JIBU02000023_gene4649	1.404e-69	239.0	COG2848@1|root,COG2848@2|Bacteria,1TQG8@1239|Firmicutes,247K4@186801|Clostridia,36DX6@31979|Clostridiaceae	186801|Clostridia	S	UPF0210 protein	-	-	-	ko:K09157	-	-	-	-	ko00000	-	-	-	DUF711
HKD1_k127_1170485_2	1121289.JHVL01000022_gene1147	4.52e-25	109.0	COG3830@1|root,COG3830@2|Bacteria,1VENW@1239|Firmicutes,24QNV@186801|Clostridia,36KHG@31979|Clostridiaceae	186801|Clostridia	T	Belongs to the UPF0237 family	-	-	-	ko:K07166	-	-	-	-	ko00000	-	-	-	ACT_6
HKD1_k127_1170485_1	1385935.N836_00875	9.386e-56	205.0	COG0561@1|root,COG0561@2|Bacteria,1GDI4@1117|Cyanobacteria	1117|Cyanobacteria	S	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD1_k127_1170485_3	1304284.L21TH_2348	7.972e-22	98.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,36ENH@31979|Clostridiaceae	186801|Clostridia	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_1178888_1	1487921.DP68_15735	3.922e-79	266.0	COG1376@1|root,COG1376@2|Bacteria,1TQMA@1239|Firmicutes,248H0@186801|Clostridia,36DSK@31979|Clostridiaceae	186801|Clostridia	S	PFAM ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_4,YkuD
HKD1_k127_1178888_4	469596.HMPREF9488_03665	1.01e-07	54.0	2DPFP@1|root,331VH@2|Bacteria,1VEX0@1239|Firmicutes,3VRXV@526524|Erysipelotrichia	526524|Erysipelotrichia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1178888_0	1196322.A370_00645	9.063e-131	422.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,36ECU@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,Nitro_FeMo-Co,ZT_dimer
HKD1_k127_1178888_2	1347392.CCEZ01000012_gene2496	1.465e-29	118.0	COG0110@1|root,COG0110@2|Bacteria,1TQEX@1239|Firmicutes,249KF@186801|Clostridia,36FMC@31979|Clostridiaceae	186801|Clostridia	S	maltose O-acetyltransferase	lacA1	-	2.3.1.18,2.3.1.79	ko:K00633,ko:K00661	-	-	-	-	ko00000,ko01000	-	-	-	Hexapep,Hexapep_2,Mac
HKD1_k127_1178888_3	1280681.AUJZ01000005_gene3246	4.607e-19	91.0	COG0668@1|root,COG0668@2|Bacteria,1TQXJ@1239|Firmicutes,24M2A@186801|Clostridia,4BXVG@830|Butyrivibrio	186801|Clostridia	M	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HKD1_k127_117893_0	1121289.JHVL01000044_gene1591	9.431e-94	312.0	COG3653@1|root,COG3653@2|Bacteria,1TSGD@1239|Firmicutes,2482F@186801|Clostridia,36GAD@31979|Clostridiaceae	186801|Clostridia	Q	N-acyl-D-aspartate D-glutamate deacylase	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_117893_1	720554.Clocl_3241	5.499e-16	79.0	2DS93@1|root,33F25@2|Bacteria,1VKBP@1239|Firmicutes,24RSQ@186801|Clostridia,3WQ4N@541000|Ruminococcaceae	186801|Clostridia	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
HKD1_k127_1179331_1	457415.HMPREF1006_01522	1.145e-36	141.0	COG4992@1|root,COG4992@2|Bacteria,3TAN5@508458|Synergistetes	508458|Synergistetes	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.13	ko:K00819	ko00330,ko01100,ko01110,ko01130,map00330,map01100,map01110,map01130	-	R00667	RC00006,RC00062	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_1179331_0	1209989.TepiRe1_2453	2.512e-98	332.0	COG3180@1|root,COG3180@2|Bacteria,1V600@1239|Firmicutes,24GPC@186801|Clostridia	186801|Clostridia	S	ammonia monooxygenase	-	-	-	ko:K07120	-	-	-	-	ko00000	-	-	-	AbrB
HKD1_k127_1183293_0	1033810.HLPCO_001530	8.039e-69	239.0	COG1322@1|root,COG1322@2|Bacteria	2|Bacteria	S	DNA recombination	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD1_k127_1183293_1	1105031.HMPREF1141_2223	1.007e-45	169.0	COG2199@1|root,COG3706@2|Bacteria,1TQMM@1239|Firmicutes,24BS4@186801|Clostridia,36FXS@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GGDEF,SpoOE-like
HKD1_k127_1183746_1	865861.AZSU01000010_gene728	2.585e-56	199.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,36HZE@31979|Clostridiaceae	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD1_k127_1183746_0	1304284.L21TH_0255	8.852e-153	496.0	COG0465@1|root,COG0465@2|Bacteria,1U2AD@1239|Firmicutes,24A06@186801|Clostridia,36FVV@31979|Clostridiaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH1	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_1183945_0	1304284.L21TH_0301	1.714e-199	626.0	COG0192@1|root,COG0192@2|Bacteria,1TPCV@1239|Firmicutes,248QF@186801|Clostridia,36DDF@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD1_k127_1183945_1	865861.AZSU01000002_gene2955	7.977e-92	321.0	COG4632@1|root,COG4632@2|Bacteria,1TQBV@1239|Firmicutes,24AWX@186801|Clostridia	186801|Clostridia	G	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,Metallophos,NAGPA,Pur_ac_phosph_N,SLH
HKD1_k127_1183955_0	642492.Clole_1360	3.01e-124	406.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_1184653_0	552398.HMPREF0866_00582	9.824e-112	365.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,3WG9F@541000|Ruminococcaceae	186801|Clostridia	C	Malic enzyme, NAD binding domain	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_1184653_1	1235799.C818_03545	6.571e-29	117.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,27IAZ@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_1186228_1	545243.BAEV01000133_gene3494	1.597e-15	81.0	COG3314@1|root,COG3314@2|Bacteria,1TR0V@1239|Firmicutes,247XA@186801|Clostridia,36ESY@31979|Clostridiaceae	186801|Clostridia	S	Sporulation integral membrane protein YlbJ	ylbJ	-	-	-	-	-	-	-	-	-	-	-	Gate
HKD1_k127_1186228_0	1514668.JOOA01000001_gene665	7.055e-64	224.0	COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia,3WGNP@541000|Ruminococcaceae	186801|Clostridia	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_1186368_0	1123009.AUID01000003_gene1910	7.378e-192	606.0	COG0019@1|root,COG0019@2|Bacteria,1TPE9@1239|Firmicutes,247X7@186801|Clostridia,267Y5@186813|unclassified Clostridiales	186801|Clostridia	E	Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine	lysA	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD1_k127_1186624_1	768710.DesyoDRAFT_0532	5.49e-10	60.0	COG5018@1|root,COG5018@2|Bacteria,1TQJZ@1239|Firmicutes,24845@186801|Clostridia	186801|Clostridia	L	'dna polymerase iii	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
HKD1_k127_1186624_0	796940.HMPREF9628_00946	2.572e-94	323.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,247JT@186801|Clostridia,25QG9@186804|Peptostreptococcaceae	186801|Clostridia	H	coproporphyrinogen III oxidase	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_1189099_1	1105031.HMPREF1141_2814	1.381e-39	150.0	COG1749@1|root,COG1749@2|Bacteria,1UHS7@1239|Firmicutes,247ZT@186801|Clostridia,36UNE@31979|Clostridiaceae	186801|Clostridia	N	flagellar basal body	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
HKD1_k127_1189099_2	1105031.HMPREF1141_2815	5.855e-18	85.0	COG1582@1|root,COG1582@2|Bacteria	2|Bacteria	N	Flagellar protein (FlbD)	flbD	-	-	ko:K02385	-	-	-	-	ko00000,ko02035	-	-	-	FlbD
HKD1_k127_1189099_0	1120746.CCNL01000011_gene1480	9.445e-75	260.0	COG1291@1|root,COG1291@2|Bacteria,2NPJ7@2323|unclassified Bacteria	2|Bacteria	N	MotA/TolQ/ExbB proton channel family	motA	-	-	ko:K02556	ko02020,ko02030,ko02040,map02020,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotA_ExbB
HKD1_k127_1190021_0	1321778.HMPREF1982_01872	3.898e-53	192.0	COG1309@1|root,COG1309@2|Bacteria,1VF0Y@1239|Firmicutes,24IZX@186801|Clostridia	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_1196498_0	428125.CLOLEP_02893	1.706e-59	214.0	COG0834@1|root,COG0834@2|Bacteria,1TT16@1239|Firmicutes,24CEZ@186801|Clostridia,3WIYH@541000|Ruminococcaceae	186801|Clostridia	ET	Belongs to the bacterial solute-binding protein 3 family	artP	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_1196498_1	537013.CLOSTMETH_00556	0.0001124	46.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,3WHWM@541000|Ruminococcaceae	186801|Clostridia	P	acid ABC transporter	ArtM	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
HKD1_k127_1197667_1	1410653.JHVC01000024_gene1137	7.863e-12	65.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,36EFR@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_1197667_0	272563.CD630_15490	7.182e-80	276.0	COG0079@1|root,COG0079@2|Bacteria,1TPUV@1239|Firmicutes,24837@186801|Clostridia,25SXH@186804|Peptostreptococcaceae	186801|Clostridia	E	Aminotransferase class I and II	hisC	GO:0003674,GO:0003824,GO:0008110,GO:0008483,GO:0016740,GO:0016769	2.6.1.9	ko:K00817	ko00340,ko00350,ko00360,ko00400,ko00401,ko00960,ko01100,ko01110,ko01130,ko01230,map00340,map00350,map00360,map00400,map00401,map00960,map01100,map01110,map01130,map01230	M00026	R00694,R00734,R03243	RC00006,RC00888	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1198804_0	579405.Dd703_1770	3.986e-242	752.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,1RNM8@1236|Gammaproteobacteria,2JEP4@204037|Dickeya	1236|Gammaproteobacteria	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_1199051_2	1195236.CTER_3522	2.26e-38	146.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24A9J@186801|Clostridia	186801|Clostridia	H	PFAM UbiA prenyltransferase	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_1199051_0	1123009.AUID01000016_gene50	7.844e-129	421.0	28JX7@1|root,2Z9MQ@2|Bacteria,1UZRY@1239|Firmicutes,24AWA@186801|Clostridia,269Y1@186813|unclassified Clostridiales	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1199051_1	1123009.AUID01000016_gene49	1.386e-66	231.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,268UZ@186813|unclassified Clostridiales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD1_k127_1199746_0	1347392.CCEZ01000043_gene417	2.055e-30	125.0	2E3AH@1|root,32YA0@2|Bacteria,1VGN7@1239|Firmicutes,25DV7@186801|Clostridia,36UF5@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1064)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1064
HKD1_k127_1199746_1	1294142.CINTURNW_2165	8.315e-21	98.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9
HKD1_k127_1199966_1	610130.Closa_2268	4.666e-18	84.0	COG2608@1|root,COG2608@2|Bacteria,1VYM0@1239|Firmicutes,24R8G@186801|Clostridia	186801|Clostridia	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
HKD1_k127_1199966_0	1151292.QEW_2938	2.613e-67	232.0	COG1853@1|root,COG1853@2|Bacteria,1V41U@1239|Firmicutes,24HTA@186801|Clostridia	186801|Clostridia	S	Conserved protein domain typically associated with flavoprotein oxygenases DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_1208065_0	1033810.HLPCO_000985	5.093e-148	481.0	COG0520@1|root,COG0520@2|Bacteria	2|Bacteria	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	csdA	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_1212893_0	642492.Clole_1310	2.602e-56	200.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_1212893_1	1226325.HMPREF1548_06752	5.724e-55	207.0	COG0814@1|root,COG0814@2|Bacteria,1UTY5@1239|Firmicutes,24BAJ@186801|Clostridia,36SUU@31979|Clostridiaceae	186801|Clostridia	E	Tryptophan/tyrosine permease family	-	-	-	-	-	-	-	-	-	-	-	-	Trp_Tyr_perm
HKD1_k127_1229623_1	1196322.A370_01940	9.527e-33	130.0	COG0679@1|root,COG0679@2|Bacteria,1TR9W@1239|Firmicutes,24AQF@186801|Clostridia,36FZA@31979|Clostridiaceae	186801|Clostridia	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD1_k127_1229623_0	1414720.CBYM010000001_gene881	2.134e-135	439.0	COG1363@1|root,COG1363@2|Bacteria,1TQ86@1239|Firmicutes,25CDF@186801|Clostridia,36DEF@31979|Clostridiaceae	186801|Clostridia	G	PFAM peptidase M42 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD1_k127_1229623_2	469616.FMAG_00363	2.192e-09	58.0	COG1506@1|root,COG1506@2|Bacteria,378NX@32066|Fusobacteria	32066|Fusobacteria	E	Prolyl oligopeptidase family	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
HKD1_k127_1231341_1	1286171.EAL2_808p01190	9.597e-39	147.0	COG1522@1|root,COG1522@2|Bacteria,1V3MI@1239|Firmicutes,24I1I@186801|Clostridia,25WEA@186806|Eubacteriaceae	186801|Clostridia	K	Cytoplasmic, score 8.87	-	-	-	ko:K03719	-	-	-	-	ko00000,ko03000,ko03036	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HKD1_k127_1231341_0	1499689.CCNN01000007_gene1275	4.501e-68	241.0	COG0697@1|root,COG0697@2|Bacteria,1TRKD@1239|Firmicutes,248I1@186801|Clostridia,36ENQ@31979|Clostridiaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_1234324_0	1341157.RF007C_11975	5.844e-131	433.0	COG3409@1|root,COG3409@2|Bacteria,1TS29@1239|Firmicutes,247SQ@186801|Clostridia,3WGZA@541000|Ruminococcaceae	186801|Clostridia	M	peptidoglycan binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,SpoIID
HKD1_k127_1234324_1	646529.Desaci_0376	1.416e-34	133.0	COG3369@1|root,COG3369@2|Bacteria,1VC9E@1239|Firmicutes,24R4M@186801|Clostridia	186801|Clostridia	S	Iron-binding zinc finger CDGSH type	-	-	-	-	-	-	-	-	-	-	-	-	zf-CDGSH
HKD1_k127_1235902_1	1347392.CCEZ01000027_gene1741	4.267e-118	388.0	COG0042@1|root,COG0042@2|Bacteria,1TQ2R@1239|Firmicutes,248HD@186801|Clostridia,36E02@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	dus	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD1_k127_1235902_2	1304284.L21TH_2191	3.197e-51	185.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,36HY8@31979|Clostridiaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_1235902_0	1121324.CLIT_13c02490	1.296e-147	473.0	COG1190@1|root,COG1190@2|Bacteria,1TP2P@1239|Firmicutes,247VX@186801|Clostridia,25QCN@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04567	ko00970,map00970	M00359,M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon,tRNA_bind
HKD1_k127_123785_1	604354.TSIB_0718	5.147e-80	274.0	COG0477@1|root,arCOG00143@2157|Archaea,2Y8EH@28890|Euryarchaeota,245MX@183968|Thermococci	183968|Thermococci	G	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_123785_0	1121289.JHVL01000026_gene190	7.527e-97	319.0	COG1592@1|root,COG1592@2|Bacteria,1TSUY@1239|Firmicutes,248GY@186801|Clostridia,36EFS@31979|Clostridiaceae	186801|Clostridia	C	Rubrerythrin	rbr3A	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_123785_2	1304284.L21TH_0869	3.171e-36	138.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,36F66@31979|Clostridiaceae	186801|Clostridia	S	Methyltransferase	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HKD1_k127_1242027_1	457421.CBFG_01022	2.324e-119	396.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,26AEH@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PrpR_N,Sigma54_activat
HKD1_k127_1242027_0	1297617.JPJD01000035_gene645	5.401e-145	465.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,26ABN@186813|unclassified Clostridiales	186801|Clostridia	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_1242027_2	1297617.JPJD01000035_gene644	2.805e-21	94.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,26AUJ@186813|unclassified Clostridiales	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_1250676_1	1121289.JHVL01000027_gene222	2.533e-05	48.0	293N1@1|root,2ZR3T@2|Bacteria,1W6IJ@1239|Firmicutes,257BJ@186801|Clostridia,36T5M@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1250676_0	428126.CLOSPI_02123	1.444e-124	408.0	COG0659@1|root,COG0659@2|Bacteria,1TPI4@1239|Firmicutes,3VNYF@526524|Erysipelotrichia	526524|Erysipelotrichia	P	Psort location CytoplasmicMembrane, score 9.99	sulP	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD1_k127_1251973_1	1345695.CLSA_c18350	2.574e-101	337.0	COG1319@1|root,COG1319@2|Bacteria,1TSNH@1239|Firmicutes,24A57@186801|Clostridia,36EPQ@31979|Clostridiaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	-	-	-	-	-	-	-	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_1251973_2	1391647.AVSV01000003_gene1516	6.172e-77	259.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24HQN@186801|Clostridia,36I5I@31979|Clostridiaceae	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS	hcrC	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_1251973_0	632245.CLP_1791	6.506e-162	514.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	xdhD	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_1253360_0	350688.Clos_2155	6.877e-178	580.0	COG0550@1|root,COG0550@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,36DHG@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim,Toprim_Crpt
HKD1_k127_1253360_1	203119.Cthe_0434	4.032e-90	308.0	COG1763@1|root,COG1763@2|Bacteria,1UI2K@1239|Firmicutes,24A23@186801|Clostridia,3WSIB@541000|Ruminococcaceae	186801|Clostridia	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1253360_2	1347392.CCEZ01000049_gene1646	1.564e-58	204.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_1253652_1	1121289.JHVL01000003_gene2298	3.791e-74	260.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,36DS7@31979|Clostridiaceae	186801|Clostridia	K	Fibronectin-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_1253652_0	1304284.L21TH_0661	5.175e-86	293.0	COG1561@1|root,COG1561@2|Bacteria,1TQHJ@1239|Firmicutes,24824@186801|Clostridia,36ED0@31979|Clostridiaceae	186801|Clostridia	S	tigr00255	yicC	-	-	-	-	-	-	-	-	-	-	-	DUF1732,YicC_N
HKD1_k127_1253652_3	1121324.CLIT_23c02950	2.998e-30	121.0	COG2052@1|root,COG2052@2|Bacteria,1VA40@1239|Firmicutes,24MXV@186801|Clostridia	186801|Clostridia	S	Belongs to the UPF0296 family	NPD7_560	-	-	ko:K09777	-	-	-	-	ko00000	-	-	-	DUF370
HKD1_k127_1253652_2	1128398.Curi_c16890	2.454e-73	252.0	COG0194@1|root,COG0194@2|Bacteria,1TP0M@1239|Firmicutes,24HEX@186801|Clostridia,2691D@186813|unclassified Clostridiales	186801|Clostridia	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD1_k127_1253652_4	1128398.Curi_c16880	8.369e-08	57.0	COG1758@1|root,COG1758@2|Bacteria,1VK74@1239|Firmicutes,24QQK@186801|Clostridia,269Z7@186813|unclassified Clostridiales	186801|Clostridia	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD1_k127_1253652_5	1423815.BACR01000006_gene292	1.017e-07	57.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,4H9WW@91061|Bacilli,3F3N8@33958|Lactobacillaceae	91061|Bacilli	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	GO:0003674,GO:0003678,GO:0003824,GO:0004003,GO:0004386,GO:0006139,GO:0006259,GO:0006260,GO:0006261,GO:0006268,GO:0006270,GO:0006281,GO:0006302,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0006996,GO:0008026,GO:0008094,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0016043,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017111,GO:0032392,GO:0032508,GO:0033554,GO:0034641,GO:0034645,GO:0042623,GO:0043138,GO:0043140,GO:0043170,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0046483,GO:0050896,GO:0051276,GO:0051716,GO:0070035,GO:0071103,GO:0071704,GO:0071840,GO:0090304,GO:0140097,GO:1901360,GO:1901576	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_1257009_0	1121335.Clst_0657	2.554e-173	552.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,3WIGS@541000|Ruminococcaceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD1_k127_1257009_1	1408422.JHYF01000001_gene2716	1.687e-63	226.0	COG0124@1|root,COG0124@2|Bacteria,1TP3D@1239|Firmicutes,24852@186801|Clostridia,36FA9@31979|Clostridiaceae	186801|Clostridia	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD1_k127_1257640_4	1410618.JNKI01000012_gene620	2.255e-49	181.0	COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,4H2F7@909932|Negativicutes	909932|Negativicutes	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD1_k127_1257640_1	592026.GCWU0000282_001228	1.102e-100	340.0	COG0448@1|root,COG0448@2|Bacteria,1TPZ3@1239|Firmicutes,2482Q@186801|Clostridia	186801|Clostridia	G	glucose-1-phosphate adenylyltransferase GlgD subunit	glgD	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD1_k127_1257640_3	1243664.CAVL020000010_gene4508	1.268e-80	274.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,4HAVA@91061|Bacilli,1ZDBA@1386|Bacillus	91061|Bacilli	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_1257640_2	1243664.CAVL020000010_gene4508	2.53e-87	294.0	COG0297@1|root,COG0297@2|Bacteria,1TQ4M@1239|Firmicutes,4HAVA@91061|Bacilli,1ZDBA@1386|Bacillus	91061|Bacilli	G	Synthesizes alpha-1,4-glucan chains using ADP-glucose	glgA	GO:0000271,GO:0003674,GO:0003824,GO:0005975,GO:0005976,GO:0005977,GO:0005978,GO:0006073,GO:0006091,GO:0006112,GO:0008150,GO:0008152,GO:0009011,GO:0009058,GO:0009059,GO:0009250,GO:0009987,GO:0015980,GO:0016051,GO:0016740,GO:0016757,GO:0016758,GO:0033692,GO:0034637,GO:0034645,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044262,GO:0044264,GO:0046527,GO:0055114,GO:0071704,GO:1901576	2.4.1.21	ko:K00703	ko00500,ko01100,ko01110,ko02026,map00500,map01100,map01110,map02026	M00565	R02421	RC00005	ko00000,ko00001,ko00002,ko01000,ko01003	-	GT5	-	Glyco_transf_5,Glycos_transf_1
HKD1_k127_1257640_0	1243664.CAVL020000010_gene4509	5.856e-129	420.0	COG0058@1|root,COG0058@2|Bacteria,1TQAJ@1239|Firmicutes,4H9XI@91061|Bacilli,1ZCRF@1386|Bacillus	91061|Bacilli	G	Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties	glgP	GO:0000272,GO:0003674,GO:0003824,GO:0004645,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005975,GO:0005976,GO:0005977,GO:0005980,GO:0006073,GO:0006091,GO:0006112,GO:0008144,GO:0008150,GO:0008152,GO:0008184,GO:0009056,GO:0009057,GO:0009251,GO:0009987,GO:0015980,GO:0016052,GO:0016740,GO:0016757,GO:0016758,GO:0019842,GO:0030170,GO:0036094,GO:0043167,GO:0043168,GO:0043170,GO:0044042,GO:0044237,GO:0044238,GO:0044247,GO:0044248,GO:0044260,GO:0044262,GO:0044264,GO:0044275,GO:0044424,GO:0044464,GO:0048037,GO:0050662,GO:0055114,GO:0070279,GO:0071704,GO:0097159,GO:1901363,GO:1901575	2.4.1.1	ko:K00688	ko00500,ko01100,ko01110,ko02026,ko04217,ko04910,ko04922,ko04931,map00500,map01100,map01110,map02026,map04217,map04910,map04922,map04931	-	R02111	-	ko00000,ko00001,ko01000	-	GT35	iYO844.BSU30940	Phosphorylase
HKD1_k127_1259130_0	1128398.Curi_c20740	1.209e-109	358.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,268B4@186813|unclassified Clostridiales	186801|Clostridia	G	Transketolase, pyrimidine binding domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_1259130_1	1304284.L21TH_2454	2.535e-40	151.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,36DP2@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_126719_1	401526.TcarDRAFT_1522	1.071e-111	368.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HKD1_k127_126719_2	759914.BP951000_0973	1.082e-15	83.0	COG4729@1|root,COG4729@2|Bacteria,2J86I@203691|Spirochaetes	203691|Spirochaetes	S	Domain of unknown function (DUF1850)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1850
HKD1_k127_126719_0	401526.TcarDRAFT_1524	5.592e-120	392.0	COG2358@1|root,COG2358@2|Bacteria,1TPXW@1239|Firmicutes,4H2B2@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter solute receptor TAXI family	-	-	-	ko:K07080	-	-	-	-	ko00000	-	-	-	NMT1_3
HKD1_k127_1268653_1	665956.HMPREF1032_00770	5.238e-94	311.0	COG0448@1|root,COG0448@2|Bacteria,1TNZW@1239|Firmicutes,24943@186801|Clostridia,3WGWG@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans	glgC	-	2.7.7.27	ko:K00975	ko00500,ko00520,ko01100,ko01110,ko02026,map00500,map00520,map01100,map01110,map02026	M00565	R00948	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,NTP_transferase
HKD1_k127_1268653_0	1105031.HMPREF1141_3290	4.535e-217	685.0	COG0296@1|root,COG0296@2|Bacteria,1TP4M@1239|Firmicutes,247WH@186801|Clostridia,36EUN@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position	glgB	-	2.4.1.18	ko:K00700	ko00500,ko01100,ko01110,map00500,map01100,map01110	M00565	R02110	-	ko00000,ko00001,ko00002,ko01000,ko04147	-	CBM48,GH13	-	Alpha-amylase,Alpha-amylase_C,CBM_48
HKD1_k127_1268779_0	1280692.AUJL01000030_gene2012	3.204e-242	754.0	COG2509@1|root,COG2509@2|Bacteria,1TP9I@1239|Firmicutes,247QM@186801|Clostridia,36F3G@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	FAD_binding_2,HI0933_like,Pyr_redox_2,Thi4
HKD1_k127_1268779_1	880071.Fleli_3672	5.475e-20	92.0	29B3Q@1|root,2ZY2C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1272378_3	509191.AEDB02000109_gene5046	9.357e-18	86.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,248C4@186801|Clostridia,3WGN2@541000|Ruminococcaceae	186801|Clostridia	P	phosphate ABC transporter	pstA	-	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_1272378_0	720554.Clocl_1707	6.444e-108	356.0	COG0573@1|root,COG0573@2|Bacteria,1TSPP@1239|Firmicutes,249KQ@186801|Clostridia,3WGFX@541000|Ruminococcaceae	186801|Clostridia	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD1_k127_1272378_1	1121024.AUCD01000038_gene449	2.799e-77	270.0	COG0226@1|root,COG0226@2|Bacteria,1TQ5X@1239|Firmicutes,4HBEB@91061|Bacilli,27G5H@186828|Carnobacteriaceae	91061|Bacilli	P	PBP superfamily domain	pstS	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD1_k127_1272378_2	536233.CLO_0315	4.051e-61	218.0	COG2199@1|root,COG3706@2|Bacteria,1VADD@1239|Firmicutes,25E7Q@186801|Clostridia,36UW7@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	2.7.7.65	ko:K21022	ko02025,map02025	-	-	-	ko00000,ko00001,ko01000	-	-	-	GAF_2,GGDEF,PAS_9,TPR_8
HKD1_k127_1272493_0	1123009.AUID01000014_gene1803	5.786e-238	742.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia,26A3C@186813|unclassified Clostridiales	186801|Clostridia	E	Aromatic amino acid lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_1272493_2	1121422.AUMW01000005_gene653	7.361e-43	160.0	28T9W@1|root,2ZFIH@2|Bacteria,1V1JV@1239|Firmicutes,24P68@186801|Clostridia,262PQ@186807|Peptococcaceae	186801|Clostridia	K	PFAM HutP	hutP	-	-	ko:K09683	-	-	-	-	ko00000,ko03000	-	-	-	HutP
HKD1_k127_1272493_3	1121422.AUMW01000005_gene653	1.731e-39	152.0	28T9W@1|root,2ZFIH@2|Bacteria,1V1JV@1239|Firmicutes,24P68@186801|Clostridia,262PQ@186807|Peptococcaceae	186801|Clostridia	K	PFAM HutP	hutP	-	-	ko:K09683	-	-	-	-	ko00000,ko03000	-	-	-	HutP
HKD1_k127_1272493_1	1121289.JHVL01000035_gene2630	5.983e-126	414.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,247NQ@186801|Clostridia,36DUZ@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	2.6.1.1	ko:K10907,ko:K11358	ko00220,ko00250,ko00270,ko00330,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map00250,map00270,map00330,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01210,map01230	-	R00355,R00694,R00734,R00896,R02433,R02619,R05052	RC00006	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_1272493_4	546269.HMPREF0389_00949	1.867e-22	100.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,25T9C@186804|Peptostreptococcaceae	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_1272501_5	642492.Clole_2737	3.156e-09	57.0	COG4905@1|root,COG4905@2|Bacteria,1VA0H@1239|Firmicutes,24NAK@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
HKD1_k127_1272501_4	1487921.DP68_17135	7.392e-13	75.0	COG0264@1|root,COG0264@2|Bacteria,1VGFM@1239|Firmicutes,24JNW@186801|Clostridia,36W3M@31979|Clostridiaceae	186801|Clostridia	J	Domain of unknown function (DUF4342)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD1_k127_1272501_1	357809.Cphy_0015	3.015e-92	308.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,21Z8Z@1506553|Lachnoclostridium	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_1272501_0	1487921.DP68_17125	4.086e-94	325.0	COG5002@1|root,COG5002@2|Bacteria,1TPSK@1239|Firmicutes,24A2N@186801|Clostridia,36EDC@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	arlS	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1272501_3	697303.Thewi_1265	1.213e-23	103.0	COG1366@1|root,COG1366@2|Bacteria,1VENG@1239|Firmicutes,24R0X@186801|Clostridia,42GW0@68295|Thermoanaerobacterales	186801|Clostridia	T	Anti-sigma F factor antagonist	spoIIAA	-	-	ko:K06378	-	-	-	-	ko00000	-	-	-	STAS
HKD1_k127_1272501_2	350688.Clos_1795	3.482e-49	179.0	COG2172@1|root,COG2172@2|Bacteria,1V6V2@1239|Firmicutes,24JPT@186801|Clostridia,36ITI@31979|Clostridiaceae	186801|Clostridia	F	Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti-anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition	spoIIAB	-	2.7.11.1	ko:K06379	-	-	-	-	ko00000,ko01000	-	-	-	HATPase_c_2
HKD1_k127_1273019_1	536227.CcarbDRAFT_3945	9.347e-44	161.0	COG0346@1|root,COG0346@2|Bacteria,1VD8Q@1239|Firmicutes,24JY7@186801|Clostridia,36K1K@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase bleomycin resistance protein dioxygenase	-	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD1_k127_1273019_0	445971.ANASTE_00324	7.698e-75	255.0	COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,25WC5@186806|Eubacteriaceae	186801|Clostridia	P	Psort location Cytoplasmic, score	cotJC	-	-	ko:K06334	-	-	-	-	ko00000	-	-	-	Mn_catalase
HKD1_k127_1273019_2	1121335.Clst_2045	7.844e-14	74.0	2E34J@1|root,32Y4N@2|Bacteria,1VESM@1239|Firmicutes,24QZX@186801|Clostridia,3WMFY@541000|Ruminococcaceae	186801|Clostridia	S	CotJB protein	cotJB	-	-	ko:K06333	-	-	-	-	ko00000	-	-	-	CotJB
HKD1_k127_1273295_1	357809.Cphy_3119	1.846e-36	143.0	COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes,24CPD@186801|Clostridia,222H5@1506553|Lachnoclostridium	186801|Clostridia	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_1273295_0	1120746.CCNL01000017_gene2448	3.288e-84	282.0	COG2316@1|root,COG2316@2|Bacteria,2NP8E@2323|unclassified Bacteria	2|Bacteria	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06951	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_1276054_4	1128398.Curi_c09980	3.094e-54	194.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,267SG@186813|unclassified Clostridiales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
HKD1_k127_1276054_0	1304284.L21TH_2143	9.661e-207	650.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,36F8C@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily	rnfC	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K03615	-	-	-	-	ko00000	-	-	-	Complex1_51K,Fer4,Fer4_10,Fer4_7,Fer4_9,RnfC_N,SLBB
HKD1_k127_1276054_3	1304284.L21TH_2144	6.559e-55	198.0	COG3290@1|root,COG3290@2|Bacteria,1UJ85@1239|Firmicutes,25EY1@186801|Clostridia,36UUR@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c
HKD1_k127_1276054_2	1304284.L21TH_2145	2.194e-71	248.0	COG0613@1|root,COG0613@2|Bacteria,1V3ZK@1239|Firmicutes,24HHA@186801|Clostridia,36J80@31979|Clostridiaceae	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	3.1.3.97	ko:K07053	-	-	R00188,R11188	RC00078	ko00000,ko01000	-	-	-	PHP
HKD1_k127_1276054_6	1304284.L21TH_2146	1.256e-30	124.0	COG0857@1|root,COG0857@2|Bacteria,1VEWN@1239|Firmicutes,24QW9@186801|Clostridia,36MIJ@31979|Clostridiaceae	186801|Clostridia	C	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HKD1_k127_1276054_1	1304284.L21TH_2147	4.833e-118	393.0	COG2000@1|root,COG2221@1|root,COG4624@1|root,COG2000@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_9
HKD1_k127_1276054_5	351627.Csac_1856	9.954e-42	158.0	COG2172@1|root,COG2172@2|Bacteria,1V6YP@1239|Firmicutes,24JJ0@186801|Clostridia,42GXK@68295|Thermoanaerobacterales	186801|Clostridia	T	PFAM ATP-binding region, ATPase domain protein	RsbW	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HATPase_c_2
HKD1_k127_1276054_7	1121289.JHVL01000002_gene2438	1.498e-29	121.0	COG4109@1|root,COG4109@2|Bacteria,1VA3T@1239|Firmicutes,24MQM@186801|Clostridia,36KUH@31979|Clostridiaceae	186801|Clostridia	K	DRTGG domain	-	-	-	-	-	-	-	-	-	-	-	-	DRTGG
HKD1_k127_1276054_8	1341157.RF007C_06895	3.049e-13	72.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1TQ50@1239|Firmicutes,249IF@186801|Clostridia,3WIH3@541000|Ruminococcaceae	186801|Clostridia	MT	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3,SPOR
HKD1_k127_1278556_1	999423.HMPREF9161_01361	7.326e-121	393.0	COG4310@1|root,COG4310@2|Bacteria,1UCAZ@1239|Firmicutes	1239|Firmicutes	S	Domain of unknown function (DUF2172)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2172,DUF4910,HTH_47,Peptidase_M28
HKD1_k127_1278556_0	864563.HMPREF9166_1899	4.609e-132	430.0	28II9@1|root,2Z8JC@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1278862_0	1410668.JNKC01000002_gene2098	8.376e-121	393.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
HKD1_k127_1278862_3	1410668.JNKC01000002_gene2097	2.886e-47	173.0	COG1869@1|root,COG1869@2|Bacteria,1VA2V@1239|Firmicutes,24MPJ@186801|Clostridia,36IY3@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose	rbsD	-	5.4.99.62	ko:K06726	ko02010,map02010	-	R08247	RC02247	ko00000,ko00001,ko01000	-	-	-	RbsD_FucU
HKD1_k127_1278862_1	1499683.CCFF01000014_gene3612	5.986e-113	370.0	COG0388@1|root,COG0388@2|Bacteria,1TQDK@1239|Firmicutes,24AWV@186801|Clostridia,36F84@31979|Clostridiaceae	186801|Clostridia	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	nit	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD1_k127_1278862_2	411902.CLOBOL_04038	2.407e-59	209.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,222HP@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_1280083_0	931276.Cspa_c21430	8.977e-153	484.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,36G19@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61	ko:K01612	ko00627,ko01120,ko01220,map00627,map01120,map01220	-	R01238	RC00391	ko00000,ko00001,ko01000	-	-	-	UbiD
HKD1_k127_1280083_1	857293.CAAU_0021	8.113e-110	366.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD1_k127_1280083_2	476272.RUMHYD_01174	7.813e-86	293.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
HKD1_k127_1283585_1	1211817.CCAT010000083_gene1648	0.0009559	51.0	COG3027@1|root,COG3027@2|Bacteria,1VIXT@1239|Firmicutes,24RYN@186801|Clostridia,36ISE@31979|Clostridiaceae	186801|Clostridia	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	zapA	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD1_k127_1283585_0	1128398.Curi_c08630	4.298e-87	299.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,267MR@186813|unclassified Clostridiales	186801|Clostridia	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD1_k127_1283802_9	997350.HMPREF9129_2062	1.289e-06	52.0	COG1722@1|root,COG1722@2|Bacteria	2|Bacteria	L	exodeoxyribonuclease VII activity	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD1_k127_1283802_1	1280692.AUJL01000007_gene1378	5.128e-67	243.0	COG1570@1|root,COG1570@2|Bacteria,1TP4E@1239|Firmicutes,247KE@186801|Clostridia,36EU5@31979|Clostridiaceae	186801|Clostridia	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD1_k127_1283802_0	1304284.L21TH_0194	5.327e-80	278.0	COG0533@1|root,COG0533@2|Bacteria,1TRPY@1239|Firmicutes,24CN4@186801|Clostridia,36IKM@31979|Clostridiaceae	186801|Clostridia	O	Glycoprotease family	gcp1	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_1283802_2	1511.CLOST_1349	1.751e-32	130.0	COG0781@1|root,COG0781@2|Bacteria,1VA9B@1239|Firmicutes,24MQ3@186801|Clostridia,25RMI@186804|Peptostreptococcaceae	186801|Clostridia	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD1_k127_1283802_3	1128398.Curi_c13800	1.462e-25	110.0	COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia,269I9@186813|unclassified Clostridiales	186801|Clostridia	S	Asp23 family, cell envelope-related function	asp	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD1_k127_1283802_8	1347392.CCEZ01000043_gene291	1.031e-06	59.0	2E3US@1|root,32YS3@2|Bacteria,1VESK@1239|Firmicutes,24R9H@186801|Clostridia,36K6Z@31979|Clostridiaceae	186801|Clostridia	S	SpoIIIAH-like protein	spoIIIAH	-	-	ko:K06397	-	-	-	-	ko00000	1.A.34.1.1	-	-	SpoIIIAH
HKD1_k127_1283802_4	1347392.CCEZ01000043_gene290	8.621e-15	81.0	2E6BB@1|root,330Z5@2|Bacteria,1VF3M@1239|Firmicutes,24RAX@186801|Clostridia,36IMX@31979|Clostridiaceae	186801|Clostridia	S	stage III sporulation protein AG	spoIIIAG	-	-	ko:K06396	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_1283802_7	398512.JQKC01000011_gene346	2.405e-07	63.0	2C2CG@1|root,2Z7PW@2|Bacteria,1TQQ2@1239|Firmicutes,24AH2@186801|Clostridia,3WM2B@541000|Ruminococcaceae	186801|Clostridia	S	TIGRFAM stage III sporulation protein AE	spoIIIAE	-	-	ko:K06394	-	-	-	-	ko00000	-	-	-	Spore_III_AE
HKD1_k127_1283802_6	621372.ACIH01000183_gene3223	1.872e-10	66.0	2CPUI@1|root,32SJW@2|Bacteria,1VA9Y@1239|Firmicutes,4HIIH@91061|Bacilli,26XDF@186822|Paenibacillaceae	91061|Bacilli	S	Stage III sporulation protein AD	spoIIIAD	-	-	ko:K06393	-	-	-	-	ko00000	-	-	-	SpoIIIAC
HKD1_k127_1283802_5	1304284.L21TH_2209	5.709e-12	66.0	2E555@1|root,32ZY3@2|Bacteria,1VEM4@1239|Firmicutes,24QNR@186801|Clostridia,36MQ6@31979|Clostridiaceae	186801|Clostridia	S	Stage III sporulation protein AC	spoIIIAC	-	-	ko:K06392	-	-	-	-	ko00000	-	-	-	SpoIIIAC
HKD1_k127_130964_0	755731.Clo1100_3829	1.305e-207	656.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,36GYN@31979|Clostridiaceae	186801|Clostridia	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_1316913_1	334413.FMG_1342	6.78e-13	70.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,22FXY@1570339|Peptoniphilaceae	186801|Clostridia	V	ABC transporter, ATP-binding protein	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_1316913_0	1286171.EAL2_808p06680	2.567e-277	872.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,25VHY@186806|Eubacteriaceae	186801|Clostridia	V	Efflux ABC transporter, permease protein	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD1_k127_1316913_2	1286171.EAL2_808p06670	1.183e-07	56.0	COG1566@1|root,COG1566@2|Bacteria,1VQX8@1239|Firmicutes,25F1D@186801|Clostridia	186801|Clostridia	V	secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_D23
HKD1_k127_1319175_0	871968.DESME_05070	3.739e-116	381.0	COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia,260GW@186807|Peptococcaceae	186801|Clostridia	S	conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	Acetyltransf_3,DUF2156
HKD1_k127_1321580_0	1123009.AUID01000009_gene502	1.088e-264	827.0	COG1154@1|root,COG1154@2|Bacteria,1TP37@1239|Firmicutes,247P1@186801|Clostridia,267VD@186813|unclassified Clostridiales	186801|Clostridia	HI	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD1_k127_1324831_4	865861.AZSU01000003_gene1786	5.28e-55	197.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36GS6@31979|Clostridiaceae	186801|Clostridia	C	Pyruvate:ferredoxin oxidoreductase core domain II	korA	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_1324831_1	1304284.L21TH_0859	3.938e-128	413.0	COG1013@1|root,COG1013@2|Bacteria,1TQJ2@1239|Firmicutes,25CAJ@186801|Clostridia,36WSB@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	korB	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_1324831_5	1511.CLOST_1471	1.374e-52	191.0	COG1014@1|root,COG1014@2|Bacteria,1V3RG@1239|Firmicutes,24I3Y@186801|Clostridia,25TGK@186804|Peptostreptococcaceae	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	korC	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR
HKD1_k127_1324831_2	1304284.L21TH_0861	3.343e-95	320.0	COG1737@1|root,COG1737@2|Bacteria,1TP7H@1239|Firmicutes,248ZD@186801|Clostridia,36DZB@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator, RpiR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_6,SIS
HKD1_k127_1324831_3	857293.CAAU_1239	5.993e-66	231.0	COG0283@1|root,COG0283@2|Bacteria,1V3IA@1239|Firmicutes,24HEF@186801|Clostridia,36DDB@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD1_k127_1324831_7	1347392.CCEZ01000043_gene428	8.695e-48	178.0	COG0204@1|root,COG0204@2|Bacteria,1U8N2@1239|Firmicutes,25B02@186801|Clostridia,36W9A@31979|Clostridiaceae	186801|Clostridia	I	Phosphate acyltransferases	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD1_k127_1324831_0	1120998.AUFC01000017_gene106	2.01e-150	503.0	COG0539@1|root,COG0761@1|root,COG0539@2|Bacteria,COG0761@2|Bacteria,1TQ9N@1239|Firmicutes,247UK@186801|Clostridia,3WCFY@538999|Clostridiales incertae sedis	186801|Clostridia	J	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K02945,ko:K03527	ko00900,ko01100,ko01110,ko01130,ko03010,map00900,map01100,map01110,map01130,map03010	M00096,M00178	R05884,R08210	RC01137,RC01487	br01610,ko00000,ko00001,ko00002,ko01000,ko03011	-	-	-	LYTB,S1
HKD1_k127_1324831_6	555088.DealDRAFT_2005	5.991e-52	189.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD1_k127_1325128_0	1280692.AUJL01000016_gene1096	1.053e-65	240.0	COG0477@1|root,COG2814@2|Bacteria,1UZ7N@1239|Firmicutes,24BF9@186801|Clostridia,36FMZ@31979|Clostridiaceae	186801|Clostridia	EGP	MFS_1 like family	-	-	-	ko:K05820	-	-	-	-	ko00000,ko02000	2.A.1.27	-	-	MFS_1,MFS_1_like
HKD1_k127_1325128_1	443254.Marpi_1679	2.133e-43	167.0	COG1529@1|root,COG1529@2|Bacteria,2GDZ7@200918|Thermotogae	200918|Thermotogae	C	Aldehyde oxidase and xanthine dehydrogenase, a b hammerhead domain	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_1327487_0	865861.AZSU01000009_gene576	5.68e-140	455.0	COG0465@1|root,COG0465@2|Bacteria,1TRV4@1239|Firmicutes,24C3E@186801|Clostridia,36FPW@31979|Clostridiaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD1_k127_1332313_1	694427.Palpr_2900	9.873e-16	82.0	COG3426@1|root,COG3426@2|Bacteria,4NJBW@976|Bacteroidetes,2FMMN@200643|Bacteroidia,22XF4@171551|Porphyromonadaceae	976|Bacteroidetes	H	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD1_k127_1332313_0	1121121.KB894291_gene1408	4.084e-244	761.0	COG0397@1|root,COG0397@2|Bacteria,1TQXD@1239|Firmicutes,4HBKH@91061|Bacilli,26U17@186822|Paenibacillaceae	91061|Bacilli	S	Belongs to the UPF0061 (SELO) family	M1-1044	-	-	-	-	-	-	-	-	-	-	-	UPF0061
HKD1_k127_1333964_1	1121334.KB911066_gene733	3.61e-78	266.0	COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,24HX6@186801|Clostridia	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_1333964_0	1235835.C814_02064	1.056e-133	440.0	COG2244@1|root,COG2244@2|Bacteria,1TR7A@1239|Firmicutes,24C7V@186801|Clostridia,3WGB1@541000|Ruminococcaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_1334724_0	1196322.A370_03325	7.345e-315	968.0	COG0129@1|root,COG0129@2|Bacteria,1TP1R@1239|Firmicutes,247UC@186801|Clostridia,36DS1@31979|Clostridiaceae	186801|Clostridia	EG	Belongs to the IlvD Edd family	ilvD	-	4.2.1.9	ko:K01687	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R04441,R05070	RC00468,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD1_k127_1342205_0	941824.TCEL_01426	1.083e-101	341.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,36E1H@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_1342205_1	641112.ACOK01000001_gene3472	6.215e-10	63.0	COG0287@1|root,COG0287@2|Bacteria,1TPXG@1239|Firmicutes,248KX@186801|Clostridia,3WI06@541000|Ruminococcaceae	186801|Clostridia	E	prephenate dehydrogenase	tyrA	-	1.3.1.12	ko:K04517	ko00400,ko00401,ko01100,ko01110,ko01130,ko01230,map00400,map00401,map01100,map01110,map01130,map01230	M00025	R01728	RC00125	ko00000,ko00001,ko00002,ko01000	-	-	-	PDH
HKD1_k127_1342415_0	1382305.AZUC01000063_gene3363	3.083e-96	320.0	COG2321@1|root,COG2321@2|Bacteria,1TQKF@1239|Firmicutes,4HB7I@91061|Bacilli,26E8G@186818|Planococcaceae	91061|Bacilli	S	Putative neutral zinc metallopeptidase	XK27_03670	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD1_k127_1342415_1	1121024.AUCD01000063_gene2165	2.844e-40	154.0	COG0589@1|root,COG0589@2|Bacteria,1V3NY@1239|Firmicutes,4HM96@91061|Bacilli	91061|Bacilli	T	universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_1344184_0	358681.BBR47_11840	5.304e-103	345.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,4HBWA@91061|Bacilli,275XT@186822|Paenibacillaceae	91061|Bacilli	S	Tripartite tricarboxylate transporter family receptor	-	-	-	ko:K07795	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctC
HKD1_k127_135325_0	1120746.CCNL01000014_gene2195	4.89e-273	848.0	COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria	2|Bacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_1355822_0	1286171.EAL2_808p02710	1.208e-125	411.0	COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,249VN@186801|Clostridia,25W97@186806|Eubacteriaceae	186801|Clostridia	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaXL	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_1358410_0	536233.CLO_1705	1.536e-121	392.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
HKD1_k127_1358410_1	37659.JNLN01000001_gene42	3.674e-102	338.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36GUR@31979|Clostridiaceae	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07651,ko:K07652	ko02020,map02020	M00458,M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1359293_1	697281.Mahau_1085	2.399e-31	141.0	COG1410@1|root,COG1410@2|Bacteria,1V7JJ@1239|Firmicutes,24AE1@186801|Clostridia,42H6D@68295|Thermoanaerobacterales	186801|Clostridia	E	vitamin B12 dependent methionine synthase, activation	metH2	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Met_synt_B12
HKD1_k127_1359293_0	748727.CLJU_c07530	1.668e-139	462.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,36DDZ@31979|Clostridiaceae	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD1_k127_1360003_2	1487921.DP68_18085	4.82e-33	128.0	COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,36FCC@31979|Clostridiaceae	186801|Clostridia	P	binding-protein-dependent transport	-	-	-	ko:K02050,ko:K15552	ko00920,ko02010,map00920,map02010	M00188,M00435	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.1,3.A.1.17.4	-	-	BPD_transp_1
HKD1_k127_1360003_0	1487921.DP68_18080	9.408e-143	456.0	COG1116@1|root,COG1116@2|Bacteria,1TRM6@1239|Firmicutes,248CG@186801|Clostridia,36GMS@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049,ko:K15555	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	ABC_tran
HKD1_k127_1360003_1	1487921.DP68_18420	1.207e-86	288.0	28M3X@1|root,2ZAHZ@2|Bacteria,1VAMQ@1239|Firmicutes,24EZ1@186801|Clostridia,36GGK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1363605_0	1304284.L21TH_1543	8.507e-152	483.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,36DSR@31979|Clostridiaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_1363605_4	1128398.Curi_c03280	4.325e-32	130.0	COG0622@1|root,COG0622@2|Bacteria,1VA0U@1239|Firmicutes,24MMK@186801|Clostridia,269B8@186813|unclassified Clostridiales	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	yfcE1	-	-	ko:K07095	-	-	-	-	ko00000	-	-	-	Metallophos_2
HKD1_k127_1363605_3	1304284.L21TH_0168	5.905e-69	240.0	COG0127@1|root,COG0127@2|Bacteria,1V6RN@1239|Firmicutes,249GK@186801|Clostridia,36HYU@31979|Clostridiaceae	186801|Clostridia	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD1_k127_1363605_2	1128398.Curi_c03260	2.053e-101	335.0	COG0689@1|root,COG0689@2|Bacteria,1TQM3@1239|Firmicutes,25E5P@186801|Clostridia,267NV@186813|unclassified Clostridiales	186801|Clostridia	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56,3.6.1.66	ko:K00989,ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03016	-	-	-	Ham1p_like,RNase_PH,RNase_PH_C
HKD1_k127_1363605_1	509191.AEDB02000108_gene1554	6.594e-117	383.0	COG0053@1|root,COG0053@2|Bacteria,1TSGY@1239|Firmicutes,2491V@186801|Clostridia,3WJUR@541000|Ruminococcaceae	186801|Clostridia	P	Dimerisation domain of Zinc Transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD1_k127_1364573_0	398512.JQKC01000011_gene316	4.934e-132	437.0	COG0860@1|root,COG1649@1|root,COG0860@2|Bacteria,COG1649@2|Bacteria,1TRTG@1239|Firmicutes,24B2F@186801|Clostridia,3WGB4@541000|Ruminococcaceae	186801|Clostridia	M	lipoprotein YddW precursor K01189	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_3,Big_2,GHL10
HKD1_k127_1364668_0	443254.Marpi_2094	1.787e-92	313.0	COG2355@1|root,COG2355@2|Bacteria,2GD5C@200918|Thermotogae	200918|Thermotogae	E	PFAM peptidase M19 renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_1364668_1	2754.EH55_12125	5.473e-30	121.0	COG0006@1|root,COG0006@2|Bacteria,3TA28@508458|Synergistetes	508458|Synergistetes	E	PFAM Metallopeptidase family M24	-	-	-	-	-	-	-	-	-	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_1368684_0	1304284.L21TH_2112	9.423e-62	218.0	COG1057@1|root,COG1057@2|Bacteria,1V3SK@1239|Firmicutes,24JFM@186801|Clostridia,36I7Z@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_1368684_1	1415774.U728_2278	1.097e-34	142.0	COG3716@1|root,COG3716@2|Bacteria,1TQA3@1239|Firmicutes,24A0K@186801|Clostridia,36DJ3@31979|Clostridiaceae	186801|Clostridia	G	PTS system mannose fructose sorbose family IID component	-	-	-	ko:K02796	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1	-	-	EII-Sor,EIID-AGA
HKD1_k127_1368903_2	1476973.JMMB01000007_gene2648	1.364e-40	152.0	COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,249ID@186801|Clostridia,25R1S@186804|Peptostreptococcaceae	186801|Clostridia	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD1_k127_1368903_0	931626.Awo_c13780	0.0	1270.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,247RW@186801|Clostridia,25VEG@186806|Eubacteriaceae	186801|Clostridia	G	Belongs to the PEP-utilizing enzyme family	ppdK	-	2.7.9.1	ko:K01006	ko00620,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00710,map00720,map01100,map01120,map01200	M00169,M00171,M00172,M00173	R00206	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD1_k127_1368903_1	350688.Clos_0947	6.539e-56	197.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36FU2@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_1370072_2	580331.Thit_1551	1.247e-72	246.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,42ER3@68295|Thermoanaerobacterales	186801|Clostridia	F	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_1370072_3	1304284.L21TH_1215	5.336e-23	100.0	COG1314@1|root,COG1314@2|Bacteria,1VG46@1239|Firmicutes,24QMG@186801|Clostridia	186801|Clostridia	U	Preprotein translocase SecG subunit	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD1_k127_1370072_0	865861.AZSU01000001_gene478	6.599e-302	939.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,36G29@31979|Clostridiaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD1_k127_1370072_1	1304284.L21TH_1211	1.002e-97	325.0	COG0596@1|root,COG0596@2|Bacteria,1VRHA@1239|Firmicutes,24PCH@186801|Clostridia,36UZX@31979|Clostridiaceae	186801|Clostridia	S	Alpha/beta hydrolase family	mhpC	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Abhydrolase_4
HKD1_k127_1374169_0	1304284.L21TH_0336	1.855e-135	436.0	COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,36DHV@31979|Clostridiaceae	186801|Clostridia	S	radical SAM protein	-	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
HKD1_k127_1374169_2	1347392.CCEZ01000049_gene1313	5.302e-33	132.0	COG0433@1|root,COG0433@2|Bacteria,1VF8X@1239|Firmicutes,24N9T@186801|Clostridia,36UPQ@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1374169_1	1304284.L21TH_0342	9.379e-70	240.0	2AFD1@1|root,315CT@2|Bacteria,1V3KJ@1239|Firmicutes,24I0E@186801|Clostridia,36J9P@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1375203_2	610130.Closa_3862	1.187e-81	279.0	COG0450@1|root,COG0450@2|Bacteria,1TQU7@1239|Firmicutes,24A31@186801|Clostridia,2217Z@1506553|Lachnoclostridium	186801|Clostridia	O	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	1.11.1.15	ko:K03386	ko04214,map04214	-	-	-	ko00000,ko00001,ko01000,ko04147	-	-	-	1-cysPrx_C,AhpC-TSA,Glyco_hydro_18
HKD1_k127_1375203_1	1304284.L21TH_1847	9.99e-84	289.0	COG1559@1|root,COG1559@2|Bacteria,1TS48@1239|Firmicutes,2493B@186801|Clostridia,36FDF@31979|Clostridiaceae	186801|Clostridia	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD1_k127_1375203_3	1347392.CCEZ01000043_gene263	1.937e-55	201.0	COG4122@1|root,COG4122@2|Bacteria,1V3YE@1239|Firmicutes,25CRS@186801|Clostridia,36WZS@31979|Clostridiaceae	186801|Clostridia	S	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_3
HKD1_k127_1375203_0	1304284.L21TH_1845	1.251e-128	418.0	COG0826@1|root,COG0826@2|Bacteria,1TPRE@1239|Firmicutes,248I3@186801|Clostridia,36E4Q@31979|Clostridiaceae	186801|Clostridia	O	peptidase U32	yegQ	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_U32,Peptidase_U32_C
HKD1_k127_137650_0	1286171.EAL2_808p05370	5.948e-140	452.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,25VKS@186806|Eubacteriaceae	186801|Clostridia	L	UvrD-like helicase C-terminal domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD1_k127_137786_2	580327.Tthe_2617	8.172e-45	175.0	COG5184@1|root,COG5492@1|root,COG5184@2|Bacteria,COG5492@2|Bacteria,1V72Z@1239|Firmicutes,24MBX@186801|Clostridia	186801|Clostridia	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg,SLH
HKD1_k127_137786_1	1161902.HMPREF0378_1336	4.068e-55	197.0	COG0590@1|root,COG0590@2|Bacteria,1V3HZ@1239|Firmicutes,24JM2@186801|Clostridia,3WCJG@538999|Clostridiales incertae sedis	186801|Clostridia	F	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD1_k127_137786_0	318464.IO99_10375	1.4e-115	382.0	COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,36H4B@31979|Clostridiaceae	186801|Clostridia	E	Alanine racemase, N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Ala_racemase_N
HKD1_k127_1384729_0	394503.Ccel_1283	1.114e-129	423.0	COG1797@1|root,COG1797@2|Bacteria,1TNY2@1239|Firmicutes,247PU@186801|Clostridia,36EBA@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source	cbiA	-	6.3.5.11,6.3.5.9	ko:K02224	ko00860,ko01100,ko01120,map00860,map01100,map01120	-	R05224,R05815	RC00010,RC01301	ko00000,ko00001,ko01000	-	-	-	AAA_26,CbiA,GATase_3
HKD1_k127_1387979_1	1235835.C814_02828	7.873e-61	216.0	2DBAJ@1|root,2Z83A@2|Bacteria,1V0GH@1239|Firmicutes,24ESG@186801|Clostridia,3WJGW@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1387979_0	445972.ANACOL_01464	1.281e-72	254.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,3WIA6@541000|Ruminococcaceae	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
HKD1_k127_1388587_3	903814.ELI_1757	1.1e-62	223.0	COG5522@1|root,COG5522@2|Bacteria,1UE9Y@1239|Firmicutes,25J5C@186801|Clostridia,25YBT@186806|Eubacteriaceae	186801|Clostridia	S	Integral membrane protein (intg_mem_TP0381)	-	-	-	-	-	-	-	-	-	-	-	-	Intg_mem_TP0381
HKD1_k127_1388587_1	981383.AEWH01000012_gene3854	4.552e-132	430.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,4H9MS@91061|Bacilli	91061|Bacilli	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.30,3.6.3.31	ko:K02010,ko:K11072	ko02010,map02010	M00190,M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.10,3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD1_k127_1388587_2	1408254.T458_15930	8.456e-104	344.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,4HAYS@91061|Bacilli,26RH5@186822|Paenibacillaceae	91061|Bacilli	P	ABC-type spermidine putrescine transport system, permease component I	-	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HKD1_k127_1388587_0	1321778.HMPREF1982_04116	7.045e-222	704.0	COG0687@1|root,COG1177@1|root,COG0687@2|Bacteria,COG1177@2|Bacteria,1TPY1@1239|Firmicutes,2483K@186801|Clostridia	186801|Clostridia	P	ABC transporter, solute-binding protein	potD	-	-	ko:K11069,ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1,SBP_bac_6,SBP_bac_8
HKD1_k127_1388952_0	1089548.KI783301_gene1079	5.124e-105	356.0	COG0577@1|root,COG0577@2|Bacteria,1TR2D@1239|Firmicutes,4H9SH@91061|Bacilli,3WDX7@539002|Bacillales incertae sedis	91061|Bacilli	V	FtsX-like permease family	XK27_05700	-	-	ko:K02004,ko:K19084	ko02010,ko02020,map02010,map02020	M00258,M00731,M00737	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.134	-	-	FtsX
HKD1_k127_1393656_2	1511.CLOST_1205	5.006e-79	265.0	COG2222@1|root,COG2222@2|Bacteria,1UCIP@1239|Firmicutes,248A5@186801|Clostridia	186801|Clostridia	M	SIS domain protein	-	-	-	ko:K19510	-	-	-	-	ko00000	-	-	-	SIS
HKD1_k127_1393656_0	1511.CLOST_1204	4.636e-208	649.0	COG0687@1|root,COG0687@2|Bacteria	2|Bacteria	E	Required for the activity of the bacterial periplasmic transport system of putrescine	potD	-	-	ko:K11069,ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1,Lipoprotein_8,SBP_bac_6,SBP_bac_8
HKD1_k127_1393656_1	1511.CLOST_1203	6.068e-138	442.0	COG1177@1|root,COG1177@2|Bacteria,1V0VD@1239|Firmicutes,25E3C@186801|Clostridia	186801|Clostridia	P	Abc transporter, permease protein	-	-	-	ko:K11070	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HKD1_k127_1393656_3	1297617.JPJD01000002_gene2759	3.472e-09	57.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,26A78@186813|unclassified Clostridiales	186801|Clostridia	E	Binding-protein-dependent transport system inner membrane component	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HKD1_k127_1394335_0	318464.IO99_02075	1.809e-102	338.0	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,24AYI@186801|Clostridia,36GR3@31979|Clostridiaceae	186801|Clostridia	S	Major Facilitator	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HKD1_k127_1394335_2	658088.HMPREF0987_02559	1.247e-63	227.0	COG0770@1|root,COG0770@2|Bacteria,1V1NG@1239|Firmicutes,24GE1@186801|Clostridia,27TSH@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Zinc dependent phospholipase C	-	-	-	-	-	-	-	-	-	-	-	-	Zn_dep_PLPC
HKD1_k127_1394335_1	509191.AEDB02000043_gene4727	7.67e-73	253.0	COG1030@1|root,COG1030@2|Bacteria,1V6UR@1239|Firmicutes,24D2S@186801|Clostridia,3WNWF@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	TspO_MBR
HKD1_k127_1394335_3	290402.Cbei_2949	1.666e-50	187.0	COG1633@1|root,COG1633@2|Bacteria,1V72Y@1239|Firmicutes,24JY4@186801|Clostridia,36I12@31979|Clostridiaceae	186801|Clostridia	S	Coat F domain	-	-	-	-	-	-	-	-	-	-	-	-	Coat_F
HKD1_k127_1394912_0	1408422.JHYF01000020_gene1828	0.0	1131.0	COG0209@1|root,COG0209@2|Bacteria,1TT3U@1239|Firmicutes,24C4U@186801|Clostridia,36G9Z@31979|Clostridiaceae	186801|Clostridia	F	TIGRFAM ribonucleoside-triphosphate reductase, adenosylcobalamin-dependent	-	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	ATP-cone,Ribonuc_red_lgC
HKD1_k127_1394912_1	555079.Toce_0795	2.25e-59	213.0	COG2871@1|root,COG3894@1|root,COG2871@2|Bacteria,COG3894@2|Bacteria,1TP0H@1239|Firmicutes,247S0@186801|Clostridia,42F3G@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF4445,Fer2
HKD1_k127_1398212_0	663278.Ethha_0726	1.099e-74	254.0	COG2719@1|root,COG2719@2|Bacteria,1TRHQ@1239|Firmicutes,248CW@186801|Clostridia,3WI1G@541000|Ruminococcaceae	186801|Clostridia	S	PFAM SpoVR	spoVR	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD1_k127_1398212_1	1304284.L21TH_1071	7.474e-46	171.0	COG1437@1|root,COG1437@2|Bacteria,1V9MR@1239|Firmicutes,24GAC@186801|Clostridia,36I5U@31979|Clostridiaceae	186801|Clostridia	F	Adenylate cyclase	-	-	4.6.1.1	ko:K05873	ko00230,map00230	-	R00089,R00434	RC00295	ko00000,ko00001,ko01000	-	-	-	CYTH
HKD1_k127_1398324_2	1304284.L21TH_1221	1.638e-90	309.0	COG2390@1|root,COG2390@2|Bacteria,1TP62@1239|Firmicutes,24B2X@186801|Clostridia,36DHS@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	cggR	-	-	ko:K05311	-	-	-	-	ko00000,ko03000	-	-	-	Sugar-bind
HKD1_k127_1398324_0	1278311.AUAL01000033_gene470	7.334e-140	451.0	COG0057@1|root,COG0057@2|Bacteria,3WSX3@544448|Tenericutes	544448|Tenericutes	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006725,GO:0006732,GO:0006733,GO:0006734,GO:0006735,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009117,GO:0009986,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0019362,GO:0019637,GO:0019674,GO:0022610,GO:0034641,GO:0043891,GO:0044237,GO:0044238,GO:0044281,GO:0044403,GO:0044406,GO:0044419,GO:0044424,GO:0044464,GO:0044650,GO:0046483,GO:0046496,GO:0051186,GO:0051704,GO:0055086,GO:0055114,GO:0071704,GO:0072524,GO:0140030,GO:0140032,GO:1901360,GO:1901564	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_1398324_1	1347392.CCEZ01000018_gene1122	6.724e-122	396.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,36ETN@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_143982_0	1410628.JNKS01000004_gene2093	4.778e-10	65.0	COG5617@1|root,COG5617@2|Bacteria,1V776@1239|Firmicutes,24J3S@186801|Clostridia,27MQU@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	PTPS_related
HKD1_k127_1441143_0	931276.Cspa_c50010	3.706e-158	520.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PrpR_N,Sigma54_activat
HKD1_k127_1441143_1	1278306.KB906906_gene179	3.332e-140	459.0	COG1288@1|root,COG1288@2|Bacteria,378WF@32066|Fusobacteria	32066|Fusobacteria	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_1441143_4	742740.HMPREF9474_01539	4.903e-85	295.0	COG3964@1|root,COG3964@2|Bacteria,1TPXM@1239|Firmicutes,24EFP@186801|Clostridia,2201R@1506553|Lachnoclostridium	186801|Clostridia	S	Amidohydrolase family	-	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_1441143_3	742741.HMPREF9475_02959	1.375e-91	312.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,25F0C@186801|Clostridia,223ZV@1506553|Lachnoclostridium	186801|Clostridia	C	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	-	-	1.1.1.26,1.1.1.310,1.1.1.399,1.1.1.95	ko:K00015,ko:K00058,ko:K16843	ko00260,ko00270,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00260,map00270,map00630,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00020	R00717,R01388,R01513,R05693	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD1_k127_1441143_2	994573.T472_0214335	5.902e-116	382.0	COG0119@1|root,COG0119@2|Bacteria,1TS0A@1239|Firmicutes,25CG9@186801|Clostridia,36W0N@31979|Clostridiaceae	186801|Clostridia	E	HMGL-like	-	-	-	-	-	-	-	-	-	-	-	-	HMGL-like
HKD1_k127_145576_2	357809.Cphy_2506	1.003e-05	51.0	COG4640@1|root,COG4640@2|Bacteria,1UVAE@1239|Firmicutes,2591W@186801|Clostridia,22382@1506553|Lachnoclostridium	186801|Clostridia	S	response to antibiotic	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_145576_1	7719.XP_009861914.1	1.383e-10	74.0	COG5244@1|root,KOG4568@2759|Eukaryota,38BCZ@33154|Opisthokonta,3B9D0@33208|Metazoa,3CVYY@33213|Bilateria,486NH@7711|Chordata	33208|Metazoa	Z	protein transport into plasma membrane raft	CLIP1	GO:0000226,GO:0000278,GO:0000775,GO:0000776,GO:0001578,GO:0003674,GO:0003779,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005634,GO:0005635,GO:0005694,GO:0005737,GO:0005768,GO:0005794,GO:0005813,GO:0005815,GO:0005819,GO:0005829,GO:0005856,GO:0005874,GO:0005875,GO:0005876,GO:0005881,GO:0005882,GO:0006810,GO:0006886,GO:0006996,GO:0007010,GO:0007017,GO:0007026,GO:0007049,GO:0007275,GO:0007349,GO:0007399,GO:0008017,GO:0008092,GO:0008104,GO:0008150,GO:0008270,GO:0009653,GO:0009987,GO:0010638,GO:0010639,GO:0010720,GO:0010975,GO:0010976,GO:0012505,GO:0015031,GO:0015630,GO:0015631,GO:0015833,GO:0016043,GO:0017022,GO:0022008,GO:0030141,GO:0030154,GO:0030424,GO:0030425,GO:0030426,GO:0030427,GO:0031110,GO:0031111,GO:0031112,GO:0031113,GO:0031114,GO:0031116,GO:0031334,GO:0031344,GO:0031346,GO:0031410,GO:0031967,GO:0031975,GO:0031982,GO:0032036,GO:0032271,GO:0032273,GO:0032501,GO:0032502,GO:0032594,GO:0032596,GO:0032886,GO:0032991,GO:0033036,GO:0033043,GO:0033267,GO:0034613,GO:0035371,GO:0036477,GO:0042599,GO:0042802,GO:0042803,GO:0042886,GO:0042995,GO:0043005,GO:0043167,GO:0043169,GO:0043226,GO:0043227,GO:0043228,GO:0043229,GO:0043231,GO:0043232,GO:0043242,GO:0043244,GO:0043254,GO:0044087,GO:0044089,GO:0044295,GO:0044422,GO:0044424,GO:0044427,GO:0044428,GO:0044430,GO:0044444,GO:0044446,GO:0044463,GO:0044464,GO:0044860,GO:0044861,GO:0045111,GO:0045169,GO:0045184,GO:0045595,GO:0045597,GO:0045664,GO:0045666,GO:0046872,GO:0046907,GO:0046914,GO:0046983,GO:0048518,GO:0048519,GO:0048522,GO:0048523,GO:0048646,GO:0048699,GO:0048731,GO:0048856,GO:0048869,GO:0050767,GO:0050769,GO:0050773,GO:0050789,GO:0050793,GO:0050794,GO:0051010,GO:0051094,GO:0051128,GO:0051129,GO:0051130,GO:0051179,GO:0051234,GO:0051239,GO:0051240,GO:0051493,GO:0051494,GO:0051495,GO:0051641,GO:0051649,GO:0051668,GO:0051960,GO:0051962,GO:0060284,GO:0061024,GO:0065007,GO:0070507,GO:0070727,GO:0070853,GO:0070854,GO:0071702,GO:0071705,GO:0071840,GO:0072657,GO:0090150,GO:0097447,GO:0097458,GO:0097708,GO:0098687,GO:0099080,GO:0099081,GO:0099503,GO:0099512,GO:0099513,GO:0120025,GO:0120035,GO:0120038,GO:0150034,GO:1900006,GO:1901588,GO:1901879,GO:1901880,GO:1902903,GO:1902904,GO:1902905,GO:1903044,GO:1990752,GO:1990778,GO:2000026	-	ko:K10421,ko:K10422,ko:K10423	ko04150,map04150	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	CAP_GLY,CLIP1_ZNF
HKD1_k127_145576_0	340099.Teth39_0852	3.438e-15	78.0	COG1977@1|root,COG1977@2|Bacteria,1VIST@1239|Firmicutes,24QYP@186801|Clostridia	186801|Clostridia	H	ThiS family	moaD	-	-	-	-	-	-	-	-	-	-	-	ThiS
HKD1_k127_1468910_0	335541.Swol_1813	8.238e-43	163.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD1_k127_148366_2	1235799.C818_02164	8.022e-07	59.0	2DKAA@1|root,3090K@2|Bacteria,1USFH@1239|Firmicutes,25AF7@186801|Clostridia,27QBU@186928|unclassified Lachnospiraceae	186801|Clostridia	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD1_k127_148366_1	1408311.JNJM01000004_gene3383	2.34e-26	110.0	COG2257@1|root,COG2257@2|Bacteria,1VF4R@1239|Firmicutes,24QSW@186801|Clostridia,2PSMM@265975|Oribacterium	186801|Clostridia	S	FlhB HrpN YscU SpaS Family	flhB1	-	-	ko:K04061	-	-	-	-	ko00000,ko02044	-	-	-	Bac_export_2
HKD1_k127_148366_0	1120746.CCNL01000011_gene1506	1.862e-45	175.0	28MVF@1|root,2ZB30@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1483772_0	411465.PEPMIC_00383	5.44e-43	162.0	arCOG13338@1|root,2ZA1I@2|Bacteria,1V5GH@1239|Firmicutes,2488N@186801|Clostridia,22IS9@1570339|Peptoniphilaceae	186801|Clostridia	S	Domain of unknown function (DUF5058)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5058
HKD1_k127_1492079_1	1304284.L21TH_1032	2.683e-82	279.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,36DSY@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
HKD1_k127_1492079_0	1121289.JHVL01000028_gene478	4.779e-157	501.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,36DSH@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_1503919_2	1304284.L21TH_2163	1.061e-75	258.0	COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,36F9C@31979|Clostridiaceae	186801|Clostridia	E	M18 family aminopeptidase	apeA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M18
HKD1_k127_1503919_3	1031288.AXAA01000015_gene295	1.026e-69	240.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24I29@186801|Clostridia,36K0A@31979|Clostridiaceae	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_1503919_0	536227.CcarbDRAFT_2641	1.321e-282	877.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36FVS@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	nuoF2	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,Fer4_20,Fer4_7,NADH_4Fe-4S,Pyr_redox_2,SLBB
HKD1_k127_1503919_1	1123288.SOV_1c07760	1.019e-267	839.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,4H2A8@909932|Negativicutes	909932|Negativicutes	C	glutamate synthase (NADPH)	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_20,NADH_4Fe-4S,Pyr_redox_2
HKD1_k127_1504231_0	1414720.CBYM010000006_gene1256	2.016e-116	382.0	COG0685@1|root,COG0685@2|Bacteria,1TQFE@1239|Firmicutes,247ZK@186801|Clostridia,36ETI@31979|Clostridiaceae	186801|Clostridia	C	reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD1_k127_1504231_1	1280689.AUJC01000001_gene2106	5.461e-52	186.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae	186801|Clostridia	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
HKD1_k127_1509028_1	1304284.L21TH_0539	1.411e-63	220.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,36EXD@31979|Clostridiaceae	186801|Clostridia	L	AAA ATPase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_1509028_2	1304284.L21TH_1251	8.14e-19	91.0	COG3086@1|root,COG3086@2|Bacteria,1VECS@1239|Firmicutes,25DMR@186801|Clostridia,36UD3@31979|Clostridiaceae	186801|Clostridia	T	Positive regulator of sigma(E), RseC/MucC	-	-	-	ko:K03803	-	-	-	-	ko00000,ko03021	-	-	-	RseC_MucC
HKD1_k127_1509028_0	1304284.L21TH_1253	8.748e-271	844.0	COG0173@1|root,COG0173@2|Bacteria,1TPCN@1239|Firmicutes,247Z3@186801|Clostridia,36EHV@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA-synt_2d,tRNA_anti-codon
HKD1_k127_1509547_1	1121289.JHVL01000002_gene2445	3.88e-40	157.0	COG0237@1|root,COG0237@2|Bacteria,1V6FS@1239|Firmicutes,24GFQ@186801|Clostridia,36J0Z@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD1_k127_1509547_0	1304284.L21TH_2157	2.505e-217	694.0	COG0749@1|root,COG0749@2|Bacteria,1TPKJ@1239|Firmicutes,248NG@186801|Clostridia,36EWE@31979|Clostridiaceae	186801|Clostridia	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD1_k127_151283_0	994573.T472_0203965	2.206e-145	469.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae	186801|Clostridia	KQ	Sigma54 specific transcriptional regulator, Fis family	aorR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
HKD1_k127_1516047_0	1128398.Curi_c06130	1.455e-148	479.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,267IX@186813|unclassified Clostridiales	186801|Clostridia	I	CoA enzyme activase uncharacterised domain (DUF2229)	hgdC2	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
HKD1_k127_1521908_2	610130.Closa_2179	1.029e-06	52.0	COG0680@1|root,COG0680@2|Bacteria,1VE76@1239|Firmicutes,24S2H@186801|Clostridia,222A3@1506553|Lachnoclostridium	186801|Clostridia	C	Hydrogenase maturation protease	-	-	-	ko:K03605	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	HycI
HKD1_k127_1521908_0	1469948.JPNB01000002_gene3693	2.725e-205	653.0	COG1231@1|root,COG1231@2|Bacteria,1TRJC@1239|Firmicutes,2484W@186801|Clostridia,36DXU@31979|Clostridiaceae	186801|Clostridia	E	amine oxidase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD1_k127_1521908_1	318464.IO99_12995	1.289e-12	67.0	2E6A2@1|root,330XY@2|Bacteria,1VISZ@1239|Firmicutes,24QK3@186801|Clostridia,36M5G@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HKD1_k127_1529651_1	1507.HMPREF0262_01192	2.801e-11	67.0	2BBWB@1|root,33GTZ@2|Bacteria,1VNYI@1239|Firmicutes,24VPR@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1529651_2	641112.ACOK01000073_gene2912	1.716e-08	58.0	2EHIB@1|root,33BA9@2|Bacteria,1VMKY@1239|Firmicutes,24UIG@186801|Clostridia,3WMA5@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1529651_0	406124.ACPC01000020_gene3952	1.725e-14	78.0	COG0860@1|root,COG0860@2|Bacteria,1V3MD@1239|Firmicutes,4HHD1@91061|Bacilli,1ZBPF@1386|Bacillus	91061|Bacilli	M	n-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,Glucosaminidase,SH3_3,SLH,SPOR
HKD1_k127_153387_0	1123511.KB905872_gene1849	6.661e-253	785.0	COG0369@1|root,COG1151@2|Bacteria,1TP8X@1239|Firmicutes,4H202@909932|Negativicutes	909932|Negativicutes	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	-	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	Prismane
HKD1_k127_153387_2	537007.BLAHAN_04484	2.944e-24	102.0	COG1773@1|root,COG1773@2|Bacteria,1VEQC@1239|Firmicutes,24QUV@186801|Clostridia,3Y0M8@572511|Blautia	186801|Clostridia	C	Psort location Cytoplasmic, score	rd	-	-	-	-	-	-	-	-	-	-	-	Rubredoxin
HKD1_k127_153387_1	1507.HMPREF0262_03059	3.421e-115	378.0	COG0657@1|root,COG0657@2|Bacteria,1TQHX@1239|Firmicutes,249GM@186801|Clostridia,36DK1@31979|Clostridiaceae	186801|Clostridia	I	Alpha beta hydrolase	-	-	-	ko:K01066	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_3
HKD1_k127_153387_3	97138.C820_01726	4.693e-10	61.0	COG4908@1|root,COG4908@2|Bacteria,1TQXH@1239|Firmicutes,24B2C@186801|Clostridia,36FWR@31979|Clostridiaceae	186801|Clostridia	I	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	AATase
HKD1_k127_1536587_3	525282.HMPREF0391_11359	7.158e-14	74.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,22GA9@1570339|Peptoniphilaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_1536587_1	536227.CcarbDRAFT_1589	1.86e-89	297.0	COG1268@1|root,COG1268@2|Bacteria,1VAY6@1239|Firmicutes,24HPU@186801|Clostridia,36I09@31979|Clostridiaceae	186801|Clostridia	S	BioY protein	bioY	-	-	ko:K03523	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	2.A.88.1,2.A.88.2	-	-	BioY
HKD1_k127_1536587_0	536227.CcarbDRAFT_1590	4.626e-176	555.0	COG0502@1|root,COG0502@2|Bacteria,1TPQ4@1239|Firmicutes,248J4@186801|Clostridia,36F2Q@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_1536587_2	1031288.AXAA01000015_gene293	1.489e-14	82.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae	186801|Clostridia	KQ	Sigma54 specific transcriptional regulator, Fis family	stc1	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_9,Sigma54_activat
HKD1_k127_1544394_1	1511.CLOST_1028	3.514e-119	388.0	COG2013@1|root,COG2013@2|Bacteria,1TPN2@1239|Firmicutes,2499B@186801|Clostridia	186801|Clostridia	S	TIGR00266 family	-	-	-	-	-	-	-	-	-	-	-	-	AIM24
HKD1_k127_1544394_3	411470.RUMGNA_03917	6.436e-23	100.0	COG3385@1|root,COG3385@2|Bacteria,1UTR4@1239|Firmicutes,24CFF@186801|Clostridia	186801|Clostridia	L	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_1544394_2	509191.AEDB02000002_gene1159	9.753e-101	331.0	COG1182@1|root,COG1182@2|Bacteria,1UZBY@1239|Firmicutes,248VP@186801|Clostridia,3WSBX@541000|Ruminococcaceae	186801|Clostridia	C	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HKD1_k127_1544394_0	1262449.CP6013_1684	0.0	1154.0	COG1484@1|root,COG1484@2|Bacteria,1VTHR@1239|Firmicutes,24ANX@186801|Clostridia,36EHY@31979|Clostridiaceae	186801|Clostridia	L	RyR domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA,RyR
HKD1_k127_1545298_1	458233.MCCL_0111	3.973e-21	95.0	COG1380@1|root,COG1380@2|Bacteria,1V9Z2@1239|Firmicutes,4IR9T@91061|Bacilli,4H1PK@90964|Staphylococcaceae	91061|Bacilli	S	LrgA family	-	-	-	ko:K05338	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	1.E.14.1	-	-	LrgA
HKD1_k127_1545298_0	458233.MCCL_0112	1.469e-92	309.0	COG1346@1|root,COG1346@2|Bacteria,1TRGN@1239|Firmicutes,4HE2Y@91061|Bacilli,4GXKA@90964|Staphylococcaceae	91061|Bacilli	M	Inhibits the expression or activity of extracellular murein hydrolases by interacting, possibly with LrgA, with the holin-like proteins CidA and or CidB. The LrgAB and CidAB proteins may affect the proton motive force of the membrane. May be involved in programmed cell death (PCD), possibly triggering PCD in response to antibiotics and environmental stresses	lrgB	-	-	ko:K05339	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	LrgB
HKD1_k127_1546490_2	941824.TCEL_01618	2.614e-83	285.0	COG1284@1|root,COG1284@2|Bacteria,1TR9J@1239|Firmicutes,24BGW@186801|Clostridia,36DT5@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised 5xTM membrane BCR, YitT family COG1284	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD1_k127_1546490_0	1120746.CCNL01000010_gene1237	0.0	1357.0	COG0542@1|root,COG0542@2|Bacteria,2NNNE@2323|unclassified Bacteria	2|Bacteria	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	GO:0003674,GO:0005488,GO:0005515,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0019538,GO:0042802,GO:0043170,GO:0044238,GO:0071704,GO:1901564	-	ko:K03694,ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD1_k127_1546490_1	1121335.Clst_1988	3.626e-140	450.0	COG0057@1|root,COG0057@2|Bacteria,1TNYU@1239|Firmicutes,247IZ@186801|Clostridia,3WGXW@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gap	-	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD1_k127_1549103_1	1128398.Curi_c13010	2.594e-26	110.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,268A6@186813|unclassified Clostridiales	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_1549103_0	293826.Amet_2878	5.304e-103	345.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA2	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_155366_0	1120746.CCNL01000014_gene2143	7.018e-140	451.0	COG0715@1|root,COG0715@2|Bacteria,2NRCU@2323|unclassified Bacteria	2|Bacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD1_k127_155366_1	1120746.CCNL01000014_gene2145	1.041e-81	274.0	COG0382@1|root,COG0382@2|Bacteria,2NP4W@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_156913_0	871968.DESME_04140	5.113e-127	411.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_156913_1	646529.Desaci_0742	1.038e-110	360.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,260IH@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_1587648_1	1128398.Curi_c00100	7.078e-46	169.0	COG1191@1|root,COG1191@2|Bacteria,1TP3Q@1239|Firmicutes,2487Z@186801|Clostridia,268RP@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma-70 region 3	sigB	-	-	ko:K03090,ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_1587648_0	1304284.L21TH_1408	1.725e-88	304.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,36DY1@31979|Clostridiaceae	186801|Clostridia	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD1_k127_1592405_1	642492.Clole_1359	9.127e-56	203.0	COG1527@1|root,COG1527@2|Bacteria,1U1QE@1239|Firmicutes,24A4E@186801|Clostridia	186801|Clostridia	C	Archaeal vacuolar-type H -ATPase subunit C	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD1_k127_1592405_0	642492.Clole_1360	2.773e-80	280.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_1599057_0	1128398.Curi_c18230	1.391e-56	206.0	COG1385@1|root,COG1385@2|Bacteria,1V1CT@1239|Firmicutes,249VK@186801|Clostridia,2691X@186813|unclassified Clostridiales	186801|Clostridia	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD1_k127_1599057_1	1160721.RBI_I00540	1.143e-42	160.0	COG2264@1|root,COG2264@2|Bacteria,1TPKI@1239|Firmicutes,247VY@186801|Clostridia,3WGGT@541000|Ruminococcaceae	186801|Clostridia	J	Methylates ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD1_k127_1600623_2	545243.BAEV01000074_gene2911	3.472e-50	183.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1TP4F@1239|Firmicutes,248MM@186801|Clostridia,36DJS@31979|Clostridiaceae	186801|Clostridia	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD1_k127_1600623_0	994573.T472_0205265	2.76e-85	287.0	COG0307@1|root,COG0307@2|Bacteria,1V1EP@1239|Firmicutes,24FVK@186801|Clostridia,36GCB@31979|Clostridiaceae	186801|Clostridia	H	riboflavin synthase, alpha subunit	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD1_k127_1600623_1	1304284.L21TH_0974	3.392e-75	255.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,36E7D@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_1627884_1	1304284.L21TH_1343	5.247e-33	130.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,36DDN@31979|Clostridiaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_1627884_0	1262449.CP6013_1368	4.489e-68	245.0	COG2508@1|root,COG2508@2|Bacteria,1TSQP@1239|Firmicutes	1239|Firmicutes	QT	COG2508, regulator of polyketide synthase expression	pucR	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR
HKD1_k127_1633551_1	1541960.KQ78_02072	2.924e-115	383.0	COG1322@1|root,COG1322@2|Bacteria,3WTE9@544448|Tenericutes	544448|Tenericutes	S	RmuC family	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD1_k127_1633551_0	552396.HMPREF0863_02111	2.779e-147	473.0	COG0136@1|root,COG0136@2|Bacteria,1TPC6@1239|Firmicutes,3VPE0@526524|Erysipelotrichia	526524|Erysipelotrichia	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	-	-	-	-	-	-	-	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_1633551_2	1286171.EAL2_808p06220	1.064e-111	374.0	COG1306@1|root,COG1306@2|Bacteria,1TQZV@1239|Firmicutes,24ADG@186801|Clostridia	186801|Clostridia	M	Putative glycosyl hydrolase domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4015
HKD1_k127_164044_1	642492.Clole_1400	3.044e-102	343.0	COG1215@1|root,COG1215@2|Bacteria,1V0TF@1239|Firmicutes,2502I@186801|Clostridia	186801|Clostridia	M	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_164044_0	537013.CLOSTMETH_02867	3.864e-179	570.0	COG1215@1|root,COG1215@2|Bacteria,1TRCI@1239|Firmicutes,248JA@186801|Clostridia	186801|Clostridia	M	PFAM Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_3
HKD1_k127_164346_0	1128398.Curi_c22890	1.504e-104	346.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,268EG@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_164346_1	1321778.HMPREF1982_01690	5.85e-96	318.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,2684B@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_1650911_1	350688.Clos_2712	2.91e-26	113.0	COG0039@1|root,COG0039@2|Bacteria,1TQIV@1239|Firmicutes,248DK@186801|Clostridia,36GJF@31979|Clostridiaceae	186801|Clostridia	C	lactate/malate dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_1_N
HKD1_k127_1650911_0	1304284.L21TH_0079	2.063e-162	523.0	COG1057@1|root,COG1057@2|Bacteria,1TQVJ@1239|Firmicutes,249M0@186801|Clostridia,36DM4@31979|Clostridiaceae	186801|Clostridia	H	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD1_k127_1654910_1	665950.HMPREF1025_00552	6.569e-42	156.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,27ITM@186928|unclassified Lachnospiraceae	186801|Clostridia	EP	Ammonium Transporter Family	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
HKD1_k127_1654910_0	1123009.AUID01000012_gene1666	5.218e-166	539.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,268QS@186813|unclassified Clostridiales	186801|Clostridia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
HKD1_k127_165589_1	1304284.L21TH_0368	8.521e-77	263.0	COG0312@1|root,COG0312@2|Bacteria,1TQJ5@1239|Firmicutes,24AGW@186801|Clostridia,36DQ8@31979|Clostridiaceae	186801|Clostridia	S	peptidase U62, modulator of DNA gyrase	-	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_165589_0	1304284.L21TH_0369	2.827e-117	379.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae	186801|Clostridia	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_1656960_1	1120998.AUFC01000016_gene77	8.568e-32	131.0	COG1525@1|root,COG2333@1|root,COG1525@2|Bacteria,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia	186801|Clostridia	M	Competence protein ComEC	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Cu_amine_oxidN1,HHH_3,Lactamase_B
HKD1_k127_1656960_0	268407.PWYN_16765	2.373e-115	377.0	COG0531@1|root,COG0531@2|Bacteria,1TQ48@1239|Firmicutes,4HBGT@91061|Bacilli,26UT2@186822|Paenibacillaceae	91061|Bacilli	E	amino acid	frlA	-	-	ko:K03294,ko:K03758	-	-	-	-	ko00000,ko02000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_1657356_1	1262915.BN574_01615	5.154e-44	164.0	COG0581@1|root,COG0581@2|Bacteria,1TP74@1239|Firmicutes,4H4D7@909932|Negativicutes	909932|Negativicutes	P	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_1657356_0	1232443.BAIA02000126_gene1109	1.098e-132	426.0	COG1117@1|root,COG1117@2|Bacteria,1TP1M@1239|Firmicutes,247RD@186801|Clostridia,2681W@186813|unclassified Clostridiales	186801|Clostridia	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_1657356_2	865861.AZSU01000002_gene2380	3.615e-13	72.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,36FX2@31979|Clostridiaceae	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_1668423_2	642492.Clole_2221	3.596e-31	124.0	COG5018@1|root,COG5018@2|Bacteria,1TQJZ@1239|Firmicutes,24845@186801|Clostridia	186801|Clostridia	L	'dna polymerase iii	-	-	-	-	-	-	-	-	-	-	-	-	RNase_T
HKD1_k127_1668423_1	1321778.HMPREF1982_02870	1.585e-92	310.0	COG2454@1|root,COG2454@2|Bacteria,1V42I@1239|Firmicutes,24BAF@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF434)	-	-	-	-	-	-	-	-	-	-	-	-	DUF434
HKD1_k127_1668423_0	756499.Desde_0991	4.71e-110	361.0	COG0789@1|root,COG0789@2|Bacteria,1TS6Z@1239|Firmicutes,24BUT@186801|Clostridia,25ZZG@186807|Peptococcaceae	186801|Clostridia	K	MerR, DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HKD1_k127_1670816_0	994573.T472_0205270	9.442e-103	336.0	COG0108@1|root,COG0807@1|root,COG0108@2|Bacteria,COG0807@2|Bacteria,1TPH9@1239|Firmicutes,248B0@186801|Clostridia,36E7D@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribBA	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10830	DHBP_synthase,GTP_cyclohydro2
HKD1_k127_1670816_1	994573.T472_0205275	1.307e-79	267.0	COG0054@1|root,COG0054@2|Bacteria,1V1DA@1239|Firmicutes,24FRS@186801|Clostridia,36HYD@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD1_k127_1670816_2	994573.T472_0205280	2.97e-76	261.0	COG0546@1|root,COG0546@2|Bacteria,1V6BF@1239|Firmicutes,24FZW@186801|Clostridia,36K90@31979|Clostridiaceae	186801|Clostridia	S	Haloacid dehalogenase-like hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase_like
HKD1_k127_1670816_3	350688.Clos_0049	1.294e-34	134.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,36E27@31979|Clostridiaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_10,POR_N,TPP_enzyme_C
HKD1_k127_1672440_2	373903.Hore_15660	4.516e-05	48.0	2E4BW@1|root,335W1@2|Bacteria,1VJ2A@1239|Firmicutes,24TX3@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2512)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2512
HKD1_k127_1672440_1	1487921.DP68_18405	5.198e-27	111.0	COG2608@1|root,COG2608@2|Bacteria,1VK5F@1239|Firmicutes,24RMA@186801|Clostridia,36P1S@31979|Clostridiaceae	186801|Clostridia	P	Heavy metal transport detoxification protein	-	-	-	-	-	-	-	-	-	-	-	-	HMA
HKD1_k127_1672440_0	1294142.CINTURNW_1103	2.779e-112	364.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,36DJE@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_1701204_1	1121324.CLIT_5c00550	3.529e-11	66.0	2DYF1@1|root,349F9@2|Bacteria,1VZW9@1239|Firmicutes,25445@186801|Clostridia	186801|Clostridia	S	ACT domain	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5
HKD1_k127_1701204_0	340099.Teth39_0014	2.011e-156	497.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,42EVA@68295|Thermoanaerobacterales	186801|Clostridia	H	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10005,iHN637.CLJU_RS10010	IlvC,IlvN
HKD1_k127_1703888_1	1511.CLOST_0206	7.155e-51	183.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,25R8W@186804|Peptostreptococcaceae	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_1703888_0	332101.JIBU02000001_gene4337	3.465e-123	400.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36GMK@31979|Clostridiaceae	186801|Clostridia	C	PFAM acetate and butyrate kinase	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD1_k127_1705405_2	1499683.CCFF01000014_gene4006	6.105e-28	114.0	COG2057@1|root,COG2057@2|Bacteria,1TNY5@1239|Firmicutes,247ZM@186801|Clostridia,36GAR@31979|Clostridiaceae	186801|Clostridia	I	3-oxoacid CoA-transferase, B subunit	ctfB1	-	2.8.3.5,2.8.3.8,2.8.3.9	ko:K01029,ko:K01035	ko00072,ko00280,ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R00410,R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_1705405_0	445972.ANACOL_00565	5.099e-104	357.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WSQQ@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_1705405_1	1235835.C814_00139	9.562e-65	225.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,2484X@186801|Clostridia,3WGIQ@541000|Ruminococcaceae	186801|Clostridia	K	response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_1709086_1	1120746.CCNL01000014_gene2198	1.731e-22	96.0	COG0064@1|root,COG0064@2|Bacteria,2NNPK@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	GO:0003674,GO:0003824,GO:0006082,GO:0006139,GO:0006399,GO:0006520,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016070,GO:0016874,GO:0016879,GO:0016884,GO:0019752,GO:0034641,GO:0034660,GO:0043038,GO:0043039,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0046483,GO:0050567,GO:0070681,GO:0071704,GO:0090304,GO:0140098,GO:0140101,GO:1901360,GO:1901564	6.1.1.12,6.3.5.6,6.3.5.7	ko:K01876,ko:K02434	ko00970,ko01100,map00970,map01100	M00359,M00360	R03905,R04212,R05577	RC00010,RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_1709086_0	1120746.CCNL01000014_gene2197	2.135e-242	756.0	COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_1709086_2	1120746.CCNL01000014_gene2196	2.626e-22	98.0	COG0721@1|root,COG0721@2|Bacteria	2|Bacteria	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	iAF987.Gmet_0076	Glu-tRNAGln
HKD1_k127_1709086_3	1120746.CCNL01000014_gene2195	4.57e-14	72.0	COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria	2|Bacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_170913_0	1449050.JNLE01000005_gene5159	4.935e-105	344.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,36EJH@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_170913_1	1449050.JNLE01000005_gene5160	1.525e-60	214.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,36EKF@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_1709655_3	382464.ABSI01000006_gene773	1.058e-15	77.0	COG0451@1|root,COG0451@2|Bacteria,46UA1@74201|Verrucomicrobia	74201|Verrucomicrobia	GM	NAD dependent epimerase/dehydratase family	-	-	-	-	-	-	-	-	-	-	-	-	Epimerase
HKD1_k127_1709655_2	632292.Calhy_1425	8.188e-34	138.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,42EXB@68295|Thermoanaerobacterales	186801|Clostridia	D	TIGRFAM Cell shape determining protein MreB Mrl	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_1709655_0	865861.AZSU01000005_gene889	1.792e-66	236.0	COG1792@1|root,COG1792@2|Bacteria,1TR1V@1239|Firmicutes,249M3@186801|Clostridia,36EKP@31979|Clostridiaceae	186801|Clostridia	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD1_k127_1709655_4	1209989.TepiRe1_1651	3.288e-08	61.0	COG2891@1|root,COG2891@2|Bacteria,1V1EJ@1239|Firmicutes,24RP5@186801|Clostridia,42HM0@68295|Thermoanaerobacterales	186801|Clostridia	M	Rod shape-determining protein	mreD	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD1_k127_1709655_1	1347392.CCEZ01000030_gene1700	3.939e-38	159.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,36DW0@31979|Clostridiaceae	186801|Clostridia	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_1762609_0	1121105.ATXL01000045_gene100	4.754e-99	327.0	COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,4HANG@91061|Bacilli,4AZAX@81852|Enterococcaceae	91061|Bacilli	S	Permease family	XK27_07275	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD1_k127_1784886_0	857293.CAAU_0377	7.747e-104	342.0	COG0766@1|root,COG0766@2|Bacteria,1TPAU@1239|Firmicutes,2488W@186801|Clostridia,36DC0@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the EPSP synthase family. MurA subfamily	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD1_k127_1784886_1	1121289.JHVL01000014_gene1770	1.025e-60	214.0	COG1279@1|root,COG1279@2|Bacteria,1V1Q2@1239|Firmicutes,24FSB@186801|Clostridia,36IZD@31979|Clostridiaceae	186801|Clostridia	S	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	ko:K06895	-	-	-	-	ko00000,ko02000	2.A.75.1	-	-	LysE
HKD1_k127_179658_3	1120746.CCNL01000011_gene1502	0.0003133	43.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW2	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD1_k127_179658_1	290402.Cbei_4018	4.492e-14	78.0	COG0835@1|root,COG0835@2|Bacteria,1V431@1239|Firmicutes,24HHD@186801|Clostridia,36IWN@31979|Clostridiaceae	186801|Clostridia	NT	PFAM CheW domain protein	cheW1	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD1_k127_179658_2	1120746.CCNL01000010_gene1465	4.792e-07	57.0	2BZRZ@1|root,332GC@2|Bacteria	2|Bacteria	S	FlgN protein	-	-	-	-	-	-	-	-	-	-	-	-	FlgN
HKD1_k127_179658_0	1120998.AUFC01000003_gene1372	8.18e-21	94.0	COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,3WD8Y@538999|Clostridiales incertae sedis	186801|Clostridia	N	Flagellar basal body rod FlgEFG protein C-terminal	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD1_k127_181699_0	1347392.CCEZ01000049_gene1638	2.761e-100	332.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,24871@186801|Clostridia,36DCB@31979|Clostridiaceae	186801|Clostridia	C	glycyl-radical enzyme activating protein family	csdA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4,Fer4_12,Radical_SAM
HKD1_k127_181699_1	865861.AZSU01000007_gene1116	6.16e-55	199.0	COG1051@1|root,COG1051@2|Bacteria,1UI9V@1239|Firmicutes,25EES@186801|Clostridia,36UN9@31979|Clostridiaceae	186801|Clostridia	F	NUDIX domain	mutT	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_181699_2	865861.AZSU01000008_gene675	1.571e-45	172.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,36HDQ@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_1852632_2	243275.TDE_0653	4.685e-64	227.0	arCOG13339@1|root,2ZBXW@2|Bacteria,2J95P@203691|Spirochaetes	203691|Spirochaetes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_1852632_0	865861.AZSU01000002_gene2813	3.003e-159	510.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,24BEY@186801|Clostridia,36J2T@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM acetylornithine deacetylase or succinyl-diaminopimelate desuccinylase	-	-	3.5.1.16,3.5.1.18	ko:K01438,ko:K01439	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R00669,R02734,R09107	RC00064,RC00090,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_1852632_1	1449126.JQKL01000004_gene615	5.503e-158	507.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,26954@186813|unclassified Clostridiales	186801|Clostridia	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_1852632_3	1120746.CCNL01000009_gene933	1.608e-24	107.0	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,2NQII@2323|unclassified Bacteria	2|Bacteria	M	Glyco_18	yaaH_2	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
HKD1_k127_1853948_0	1232449.BAHV02000016_gene1915	6.941e-85	287.0	COG1388@1|root,COG3976@1|root,COG1388@2|Bacteria,COG3976@2|Bacteria,1TVMR@1239|Firmicutes,25MU3@186801|Clostridia,26C9Z@186813|unclassified Clostridiales	186801|Clostridia	M	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD1_k127_1853948_1	591001.Acfer_1750	4.035e-21	93.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,4H4KB@909932|Negativicutes	909932|Negativicutes	S	PFAM C4-dicarboxylate anaerobic carrier-like	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_185409_1	1230342.CTM_09556	5.229e-215	670.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
HKD1_k127_185409_2	1410653.JHVC01000002_gene4432	1.156e-25	109.0	COG0694@1|root,COG0694@2|Bacteria,1VAAU@1239|Firmicutes,24R29@186801|Clostridia,36MMR@31979|Clostridiaceae	186801|Clostridia	O	NifU-like domain	-	-	-	-	-	-	-	-	-	-	-	-	NifU
HKD1_k127_185409_3	1410653.JHVC01000002_gene4433	6.878e-18	85.0	COG2030@1|root,COG2030@2|Bacteria,1UP6Q@1239|Firmicutes,24U2P@186801|Clostridia,36V9W@31979|Clostridiaceae	186801|Clostridia	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_185409_0	401526.TcarDRAFT_1831	0.0	1544.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,1TQJ2@1239|Firmicutes,4H2K7@909932|Negativicutes	909932|Negativicutes	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_1854964_0	457570.Nther_0338	9.845e-73	252.0	COG1763@1|root,COG1763@2|Bacteria,1V42Z@1239|Firmicutes,24IMW@186801|Clostridia	186801|Clostridia	H	molybdopterin-guanine dinucleotide biosynthesis	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	FeS,MobB
HKD1_k127_1885200_1	1243664.CAVL020000006_gene4964	4.759e-49	178.0	COG0438@1|root,COG0438@2|Bacteria,1V0AQ@1239|Firmicutes,4HEBD@91061|Bacilli,1ZN0Y@1386|Bacillus	91061|Bacilli	M	Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD1_k127_1885200_0	398512.JQKC01000015_gene4693	1.857e-106	356.0	COG0438@1|root,COG0438@2|Bacteria,1TRCM@1239|Firmicutes,24B86@186801|Clostridia,3WIQ7@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyltransferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD1_k127_1887357_3	1511.CLOST_0806	3.587e-27	115.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,25RAH@186804|Peptostreptococcaceae	186801|Clostridia	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
HKD1_k127_1887357_1	1449050.JNLE01000005_gene5188	7.782e-65	227.0	COG1896@1|root,COG1896@2|Bacteria,1TSDU@1239|Firmicutes,24FT8@186801|Clostridia,36IZU@31979|Clostridiaceae	186801|Clostridia	S	HD containing hydrolase-like enzyme	yfbR	-	3.1.3.89	ko:K07023,ko:K08722	ko00240,ko01100,map00240,map01100	-	R01569,R01664,R01968,R02088,R02102,R10776	RC00017	ko00000,ko00001,ko01000	-	-	-	HD_2,HD_3
HKD1_k127_1887357_2	903814.ELI_2248	2.928e-63	220.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,25VCN@186806|Eubacteriaceae	186801|Clostridia	L	SNF2 family N-terminal domain	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD1_k127_1887357_0	702450.CUW_2431	6.416e-119	389.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,3VPRH@526524|Erysipelotrichia	526524|Erysipelotrichia	L	SNF2 family N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD1_k127_1887822_0	445973.CLOBAR_01077	3.247e-244	759.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,25QED@186804|Peptostreptococcaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_1891597_0	748727.CLJU_c13910	1.052e-72	252.0	COG2186@1|root,COG2186@2|Bacteria,1V0HM@1239|Firmicutes,24PT6@186801|Clostridia,36W7T@31979|Clostridiaceae	186801|Clostridia	K	Regulatory protein GntR HTH	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD1_k127_1891597_1	748727.CLJU_c13880	3.157e-19	87.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36HI7@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_1893854_3	871968.DESME_14905	3.528e-12	67.0	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,26099@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD1_k127_1893854_2	1449337.JQLL01000001_gene2028	7.178e-62	219.0	COG2059@1|root,COG2059@2|Bacteria,1V22C@1239|Firmicutes,4HI24@91061|Bacilli,27G99@186828|Carnobacteriaceae	91061|Bacilli	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_1893854_1	1499684.CCNP01000023_gene3155	1.219e-68	237.0	COG2059@1|root,COG2059@2|Bacteria,1V42U@1239|Firmicutes,24HA0@186801|Clostridia,36ICK@31979|Clostridiaceae	186801|Clostridia	P	Chromate	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD1_k127_1893854_0	1301100.HG529378_gene4093	1.987e-110	362.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_1894793_0	1321814.HMPREF9089_00619	1.155e-195	616.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,25V9C@186806|Eubacteriaceae	186801|Clostridia	J	Psort location Cytoplasmic, score 10.00	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_1894793_2	1095770.CAHE01000094_gene1928	5.564e-100	334.0	COG0834@1|root,COG0834@2|Bacteria,1V7CS@1239|Firmicutes,25E43@186801|Clostridia,22J8B@1570339|Peptoniphilaceae	186801|Clostridia	ET	An automated process has identified a potential problem with this gene model	-	-	-	ko:K17073	ko02010,map02010	M00589	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.20	-	-	SBP_bac_3
HKD1_k127_1894793_1	1118057.CAGX01000054_gene27	6.864e-106	348.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,24BMB@186801|Clostridia,22GYZ@1570339|Peptoniphilaceae	186801|Clostridia	P	ABC transporter, permease protein	-	-	-	ko:K17073,ko:K17074	ko02010,map02010	M00589	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.20	-	-	BPD_transp_1,SBP_bac_3
HKD1_k127_1894793_3	457396.CSBG_03181	3.999e-72	246.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,36E89@31979|Clostridiaceae	186801|Clostridia	E	ABC transporter	glnQ	-	3.6.3.21	ko:K02028,ko:K17074,ko:K17076	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3,3.A.1.3.20	-	-	ABC_tran
HKD1_k127_1905780_0	1304284.L21TH_1643	3.951e-168	537.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,36F91@31979|Clostridiaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_1905780_2	1128398.Curi_c23820	2.394e-45	177.0	COG0760@1|root,COG0760@2|Bacteria,1TX3R@1239|Firmicutes,24C7H@186801|Clostridia,269ER@186813|unclassified Clostridiales	186801|Clostridia	O	SurA N-terminal domain	prsA	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3,SurA_N_3
HKD1_k127_1905780_1	1304284.L21TH_1645	8.7e-60	209.0	COG2002@1|root,COG2002@2|Bacteria,1V02A@1239|Firmicutes,248XR@186801|Clostridia,36E8G@31979|Clostridiaceae	186801|Clostridia	K	stage V sporulation protein T	spoVT	-	-	ko:K04769	-	-	-	-	ko00000,ko03000	-	-	-	MazE_antitoxin,SpoVT_C
HKD1_k127_1929301_2	997346.HMPREF9374_1437	6.243e-21	95.0	COG1506@1|root,COG1506@2|Bacteria,1TQ85@1239|Firmicutes,4HAC0@91061|Bacilli	91061|Bacilli	EU	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9,Peptidase_S9_N
HKD1_k127_1929301_0	1121289.JHVL01000003_gene2305	3.271e-38	148.0	COG0597@1|root,COG0597@2|Bacteria,1VA9R@1239|Firmicutes,24QPP@186801|Clostridia,36K1I@31979|Clostridiaceae	186801|Clostridia	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD1_k127_1929301_1	941824.TCEL_01771	1.233e-34	138.0	COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia,36IWC@31979|Clostridiaceae	186801|Clostridia	S	S4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	S4
HKD1_k127_1943826_4	1121422.AUMW01000019_gene1806	8.809e-18	83.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,24914@186801|Clostridia,26093@186807|Peptococcaceae	186801|Clostridia	G	PFAM Transketolase, C-terminal domain	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_1943826_2	555088.DealDRAFT_2329	2.588e-55	198.0	COG1329@1|root,COG1329@2|Bacteria,1V40K@1239|Firmicutes,24HHP@186801|Clostridia	186801|Clostridia	K	PFAM Transcription factor CarD	carD	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD1_k127_1943826_0	1304284.L21TH_1876	3.34e-125	411.0	COG4956@1|root,COG4956@2|Bacteria,1TP0P@1239|Firmicutes,248F4@186801|Clostridia,36DKW@31979|Clostridiaceae	186801|Clostridia	S	PFAM PilT protein domain protein	yacL	-	-	-	-	-	-	-	-	-	-	-	PIN,PIN_4,TRAM
HKD1_k127_1943826_3	1304284.L21TH_2376	1.31e-50	187.0	COG2323@1|root,COG2323@2|Bacteria,1V3NW@1239|Firmicutes,24H1Q@186801|Clostridia,36DZ1@31979|Clostridiaceae	186801|Clostridia	K	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD1_k127_1943826_5	203119.Cthe_3174	1.099e-11	70.0	2E4QX@1|root,32ZJH@2|Bacteria,1VFAX@1239|Firmicutes,24S6V@186801|Clostridia,3WPS0@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4363)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4363
HKD1_k127_1943826_1	1121342.AUCO01000005_gene164	6.602e-94	312.0	COG0179@1|root,COG0179@2|Bacteria,1TQDQ@1239|Firmicutes,248AJ@186801|Clostridia,36EXG@31979|Clostridiaceae	186801|Clostridia	Q	PFAM fumarylacetoacetate (FAA) hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FAA_hydrolase
HKD1_k127_1990177_0	1121289.JHVL01000014_gene1808	1.707e-227	714.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,36DSJ@31979|Clostridiaceae	186801|Clostridia	I	CoA-substrate-specific enzyme activase	hgdC2	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
HKD1_k127_199317_0	755731.Clo1100_2838	4.329e-06	51.0	COG5492@1|root,COG5492@2|Bacteria,1V17S@1239|Firmicutes,24GRG@186801|Clostridia,36I5Q@31979|Clostridiaceae	186801|Clostridia	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SLH
HKD1_k127_20035_0	1410632.JHWW01000002_gene2076	1.988e-111	374.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,27J59@186928|unclassified Lachnospiraceae	186801|Clostridia	K	Cell envelope-related transcriptional attenuator domain	-	-	-	-	-	-	-	-	-	-	-	-	DNA_PPF,LytR_cpsA_psr,NMT1
HKD1_k127_2008067_0	33035.JPJF01000029_gene2128	6.625e-159	514.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_202020_0	864565.HMPREF0379_0728	1.156e-90	301.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,25S7G@186804|Peptostreptococcaceae	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
HKD1_k127_202020_1	864565.HMPREF0379_0727	2.302e-43	163.0	COG3090@1|root,COG3090@2|Bacteria,1V3PZ@1239|Firmicutes,24HA7@186801|Clostridia	186801|Clostridia	G	COG COG3090 TRAP-type C4-dicarboxylate transport system, small permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_202094_0	1128398.Curi_c12220	3.987e-138	446.0	COG0082@1|root,COG0082@2|Bacteria,1TQ40@1239|Firmicutes,24998@186801|Clostridia,2688Y@186813|unclassified Clostridiales	186801|Clostridia	E	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system	aroC	-	4.2.3.5	ko:K01736	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01714	RC00586	ko00000,ko00001,ko00002,ko01000	-	-	-	Chorismate_synt
HKD1_k127_202094_1	195103.CPF_0689	1.634e-27	113.0	COG0128@1|root,COG0128@2|Bacteria,1TPIH@1239|Firmicutes,2488G@186801|Clostridia,36E1H@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	-	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD1_k127_2026807_0	642492.Clole_4146	5.104e-66	229.0	COG3945@1|root,COG3945@2|Bacteria,1V3TS@1239|Firmicutes,24HUR@186801|Clostridia	186801|Clostridia	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD1_k127_2026807_1	1123009.AUID01000006_gene915	1.1e-55	200.0	2B9GQ@1|root,322UQ@2|Bacteria,1V748@1239|Firmicutes,24JPR@186801|Clostridia,269HA@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_203258_6	1286171.EAL2_808p03110	4.391e-26	111.0	COG4708@1|root,COG4708@2|Bacteria,1V9YK@1239|Firmicutes,24N9H@186801|Clostridia,25WR7@186806|Eubacteriaceae	186801|Clostridia	S	QueT transporter	-	-	-	-	-	-	-	-	-	-	-	-	QueT
HKD1_k127_203258_5	1304284.L21TH_0928	7.451e-55	194.0	COG0103@1|root,COG0103@2|Bacteria,1V3MQ@1239|Firmicutes,24H94@186801|Clostridia,36IRJ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD1_k127_203258_4	865861.AZSU01000001_gene54	1.748e-60	211.0	COG0102@1|root,COG0102@2|Bacteria,1V3HX@1239|Firmicutes,24HD9@186801|Clostridia,36HZ3@31979|Clostridiaceae	186801|Clostridia	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD1_k127_203258_3	1511.CLOST_2163	9.223e-82	279.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248W2@186801|Clostridia,25R8Z@186804|Peptostreptococcaceae	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD1_k127_203258_1	1304284.L21TH_0925	7.761e-111	363.0	COG0619@1|root,COG0619@2|Bacteria,1TQ0E@1239|Firmicutes,248AB@186801|Clostridia,36FFB@31979|Clostridiaceae	186801|Clostridia	P	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfT	-	-	ko:K16783,ko:K16785	ko02010,map02010	M00581,M00582	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.25,3.A.1.25.1,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	CbiQ
HKD1_k127_203258_2	1033744.CAEL01000001_gene396	2.237e-103	344.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,22G1K@1570339|Peptoniphilaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	-	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD1_k127_203258_0	37659.JNLN01000001_gene663	7.837e-118	384.0	COG1122@1|root,COG1122@2|Bacteria,1TPH8@1239|Firmicutes,248A2@186801|Clostridia,36DXB@31979|Clostridiaceae	186801|Clostridia	P	ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates	ecfA1	-	-	ko:K16786,ko:K16787	ko02010,map02010	M00582	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.25,3.A.1.28,3.A.1.29,3.A.1.30,3.A.1.31,3.A.1.32,3.A.1.33,3.A.1.35	-	-	ABC_tran
HKD1_k127_203258_7	351627.Csac_1644	1.579e-05	49.0	COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,42G4S@68295|Thermoanaerobacterales	186801|Clostridia	K	Transcriptional regulator, LysR family	-	-	-	ko:K21900	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,LysR_substrate
HKD1_k127_203948_1	1347392.CCEZ01000074_gene1908	1.646e-75	261.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_203948_0	293826.Amet_1637	5.182e-85	286.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,36DGN@31979|Clostridiaceae	186801|Clostridia	P	Potassium uptake protein	ktrC	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_203948_2	1121324.CLIT_10c02580	3.76e-58	211.0	COG0566@1|root,COG0566@2|Bacteria,1V3JP@1239|Firmicutes,248DV@186801|Clostridia,25RAX@186804|Peptostreptococcaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	spoU	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD1_k127_203948_3	1304284.L21TH_1031	3.399e-39	149.0	COG0016@1|root,COG0016@2|Bacteria,1TPFW@1239|Firmicutes,2486E@186801|Clostridia,36DSH@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD1_k127_209957_2	865861.AZSU01000001_gene498	1.861e-15	77.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_209957_1	742738.HMPREF9460_01263	1.816e-89	301.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,269P4@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD1_k127_209957_0	865861.AZSU01000001_gene510	8.799e-150	477.0	COG0329@1|root,COG0329@2|Bacteria,1TPSG@1239|Firmicutes,249ZX@186801|Clostridia,36GI0@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	-	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_2114073_1	1120998.AUFC01000005_gene630	1.212e-149	479.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3WCY8@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_2114073_0	1031288.AXAA01000010_gene439	3.154e-157	499.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,36DQ3@31979|Clostridiaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
HKD1_k127_2128302_1	180332.JTGN01000006_gene3215	2.847e-47	171.0	COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia	186801|Clostridia	C	Iron-only hydrogenase maturation rSAM protein HydE	hydE	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_2128302_0	180332.JTGN01000006_gene3216	2.555e-240	745.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia	186801|Clostridia	C	biosynthesis protein ThiH	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_2128651_5	1232449.BAHV02000002_gene8	4.852e-37	140.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1TNZ1@1239|Firmicutes,247PS@186801|Clostridia,267WW@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH
HKD1_k127_2128651_0	398512.JQKC01000029_gene4336	2.325e-113	373.0	2BZ6P@1|root,2ZAUT@2|Bacteria,1V1AT@1239|Firmicutes,24984@186801|Clostridia,3WN4M@541000|Ruminococcaceae	186801|Clostridia	S	Domain of unknown function (DUF2935)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2935
HKD1_k127_2128651_2	484770.UFO1_3746	1.898e-77	269.0	COG2240@1|root,COG2240@2|Bacteria,1TRCR@1239|Firmicutes,4H4A0@909932|Negativicutes	909932|Negativicutes	H	Belongs to the pyridoxine kinase family	-	-	2.7.1.35	ko:K00868	ko00750,ko01100,map00750,map01100	-	R00174,R01909,R02493	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	Phos_pyr_kin
HKD1_k127_2128651_4	1304284.L21TH_1687	7.712e-53	195.0	COG3583@1|root,COG3584@1|root,COG3583@2|Bacteria,COG3584@2|Bacteria,1TTIK@1239|Firmicutes,24997@186801|Clostridia,36DTZ@31979|Clostridiaceae	186801|Clostridia	S	G5 domain protein	yabE	-	-	-	-	-	-	-	-	-	-	-	3D,DUF348,G5
HKD1_k127_2128651_1	1304284.L21TH_1844	2.344e-87	293.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,24850@186801|Clostridia,36DNP@31979|Clostridiaceae	186801|Clostridia	F	Cytidine monophosphokinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HKD1_k127_2128651_3	1304284.L21TH_1686	2.22e-62	219.0	COG1658@1|root,COG1658@2|Bacteria,1V3K3@1239|Firmicutes,24I8W@186801|Clostridia,36I6Z@31979|Clostridiaceae	186801|Clostridia	J	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step	rnmV	-	3.1.26.8	ko:K05985	-	-	-	-	ko00000,ko01000	-	-	-	DUF4093,Toprim,Toprim_4
HKD1_k127_2128651_6	865861.AZSU01000002_gene2520	4.921e-10	60.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,36DEP@31979|Clostridiaceae	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_2130695_0	545697.HMPREF0216_00794	2.482e-51	197.0	COG4399@1|root,COG4399@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF445,DUF4953,DUF5117,DUF5118
HKD1_k127_2135962_2	941824.TCEL_01584	3.158e-60	211.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016774,GO:0044237,GO:0044424,GO:0044464,GO:0047761	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD1_k127_2135962_3	1347392.CCEZ01000004_gene760	3.49e-43	162.0	COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,36UV9@31979|Clostridiaceae	186801|Clostridia	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
HKD1_k127_2135962_6	1121324.CLIT_18c00220	4.143e-18	85.0	COG0455@1|root,COG0455@2|Bacteria,1V1FH@1239|Firmicutes,24DP7@186801|Clostridia,25R35@186804|Peptostreptococcaceae	186801|Clostridia	D	bacterial-type flagellum organization	-	-	-	-	-	-	-	-	-	-	-	-	CbiA
HKD1_k127_2135962_5	865861.AZSU01000001_gene93	1.315e-26	111.0	COG1143@1|root,COG1143@2|Bacteria,1UHZA@1239|Firmicutes,24QVY@186801|Clostridia,36UN5@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	1.2.7.3	ko:K00176	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Fer4,Fer4_4,Fer4_7
HKD1_k127_2135962_0	1121289.JHVL01000017_gene741	1.539e-162	518.0	COG0674@1|root,COG0674@2|Bacteria,1TSSC@1239|Firmicutes,248I6@186801|Clostridia,36EW0@31979|Clostridiaceae	186801|Clostridia	C	pyruvate flavodoxin ferredoxin oxidoreductase domain protein	vorB	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR_N
HKD1_k127_2135962_1	1347392.CCEZ01000004_gene763	1.073e-139	445.0	COG1013@1|root,COG1013@2|Bacteria,1UZ67@1239|Firmicutes,247Q7@186801|Clostridia,36DRF@31979|Clostridiaceae	186801|Clostridia	C	PFAM thiamine pyrophosphate protein domain protein TPP-binding	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_2135962_4	293826.Amet_4303	4.983e-37	140.0	COG1014@1|root,COG1014@2|Bacteria,1UYYG@1239|Firmicutes,24I53@186801|Clostridia,36G5Z@31979|Clostridiaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	-	-	1.2.7.3	ko:K00177	ko00020,ko00720,ko01100,ko01120,ko01200,map00020,map00720,map01100,map01120,map01200	M00009,M00011,M00173,M00620	R01197	RC00004,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	POR,Rubrerythrin
HKD1_k127_2144251_3	293826.Amet_2076	2.564e-56	199.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,36DQT@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_2144251_2	1511.CLOST_2203	2.414e-140	450.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,25TKX@186804|Peptostreptococcaceae	186801|Clostridia	E	Belongs to the binding-protein-dependent transport system permease family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_2144251_1	1511.CLOST_2204	2.372e-181	574.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,25T9N@186804|Peptostreptococcaceae	186801|Clostridia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_2144251_0	696369.KI912183_gene2577	0.0	1070.0	COG1924@1|root,COG3580@1|root,COG3581@1|root,COG1924@2|Bacteria,COG3580@2|Bacteria,COG3581@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,260RR@186807|Peptococcaceae	186801|Clostridia	I	BadF BadG BcrA BcrD	hgdC2	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG,DUF2229,HGD-D
HKD1_k127_214952_0	411460.RUMTOR_00664	7.08e-177	561.0	COG0008@1|root,COG0008@2|Bacteria,1TP8G@1239|Firmicutes,247Y0@186801|Clostridia,3XYKW@572511|Blautia	186801|Clostridia	J	Psort location Cytoplasmic, score 9.98	glnS	-	6.1.1.18	ko:K01886	ko00970,ko01100,map00970,map01100	M00359,M00360	R03652	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c,tRNA-synt_1c_C
HKD1_k127_214952_1	1128398.Curi_c12380	6.382e-126	413.0	COG2519@1|root,COG2519@2|Bacteria,1UNSC@1239|Firmicutes,25H3X@186801|Clostridia	186801|Clostridia	J	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_32
HKD1_k127_2150_0	1048983.EL17_02065	1.587e-05	55.0	COG3279@1|root,COG3279@2|Bacteria,4NFPV@976|Bacteroidetes,47PNU@768503|Cytophagia	976|Bacteroidetes	KT	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HKD1_k127_2150_1	1449050.JNLE01000003_gene2150	2.848e-05	47.0	COG0514@1|root,COG0514@2|Bacteria,1V63N@1239|Firmicutes,24A9F@186801|Clostridia,36F60@31979|Clostridiaceae	186801|Clostridia	L	Nuclease-related domain	-	-	-	-	-	-	-	-	-	-	-	-	HRDC,NERD
HKD1_k127_215684_0	293826.Amet_3078	3.41e-304	944.0	COG0577@1|root,COG0577@2|Bacteria,1TRE5@1239|Firmicutes,24CGY@186801|Clostridia,36DKB@31979|Clostridiaceae	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_2188752_0	697303.Thewi_1760	3.265e-196	616.0	COG1883@1|root,COG1883@2|Bacteria,1TPEP@1239|Firmicutes,248ET@186801|Clostridia,42EP7@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM Na transporting methylmalonyl-CoA oxaloacetate decarboxylase beta subunit	gcdB	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD1_k127_219101_0	180332.JTGN01000014_gene761	8.481e-186	589.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia	186801|Clostridia	F	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
HKD1_k127_219101_1	545243.BAEV01000057_gene175	1.514e-10	63.0	COG1192@1|root,COG1192@2|Bacteria,1UI78@1239|Firmicutes,25ECF@186801|Clostridia,36I2D@31979|Clostridiaceae	186801|Clostridia	D	Involved in chromosome partitioning	yqeC	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2209222_1	1123009.AUID01000010_gene541	3.698e-15	77.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,269TB@186813|unclassified Clostridiales	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_2209222_0	546269.HMPREF0389_01354	2.952e-126	407.0	COG1834@1|root,COG1834@2|Bacteria,1TRPV@1239|Firmicutes,24AKW@186801|Clostridia	186801|Clostridia	E	Amidinotransferase	-	-	3.5.3.18	ko:K01482	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	Amidinotransf
HKD1_k127_2209222_2	1304284.L21TH_0307	3.827e-09	59.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,36DHD@31979|Clostridiaceae	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_2210826_0	865861.AZSU01000004_gene1045	8.361e-117	378.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_2210826_1	1540257.JQMW01000009_gene3681	6.033e-22	102.0	COG0679@1|root,COG0679@2|Bacteria,1UY4N@1239|Firmicutes,24ACC@186801|Clostridia,36DT1@31979|Clostridiaceae	186801|Clostridia	S	auxin efflux carrier	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans,SBF
HKD1_k127_2212458_1	1196322.A370_03869	8.098e-58	204.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae	186801|Clostridia	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
HKD1_k127_2212458_0	931276.Cspa_c16100	1.342e-105	346.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae	186801|Clostridia	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
HKD1_k127_2212898_0	1410653.JHVC01000007_gene570	6.54e-250	773.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,36DP4@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_22286_1	1120998.AUFC01000002_gene2752	3.081e-78	267.0	COG2844@1|root,COG2844@2|Bacteria,1V2GH@1239|Firmicutes,24FRR@186801|Clostridia	186801|Clostridia	O	HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_22286_0	555079.Toce_0514	1.853e-114	377.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia	186801|Clostridia	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red,Fer4,Fer4_17
HKD1_k127_22286_2	1347392.CCEZ01000015_gene2769	3.102e-74	253.0	COG0503@1|root,COG0503@2|Bacteria,1V1XS@1239|Firmicutes	1239|Firmicutes	F	Psort location Cytoplasmic, score	-	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD1_k127_22286_3	768706.Desor_3235	5.564e-44	164.0	COG1607@1|root,COG1607@2|Bacteria,1V3S2@1239|Firmicutes,24JIT@186801|Clostridia,265WG@186807|Peptococcaceae	186801|Clostridia	I	PFAM thioesterase superfamily	yciA	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_22286_4	1294142.CINTURNW_2578	3.461e-36	139.0	2E481@1|root,32Z3Y@2|Bacteria,1VFF1@1239|Firmicutes,24SN5@186801|Clostridia,36NFZ@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_224380_2	756499.Desde_3909	4.869e-12	70.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,264RR@186807|Peptococcaceae	186801|Clostridia	S	PFAM ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_224380_0	357809.Cphy_0180	1.44e-61	218.0	COG5658@1|root,COG5658@2|Bacteria,1VBIT@1239|Firmicutes,24HIG@186801|Clostridia,21ZFF@1506553|Lachnoclostridium	186801|Clostridia	S	SdpI/YhfL protein family	sdpI	-	-	-	-	-	-	-	-	-	-	-	DUF1648,SdpI
HKD1_k127_224380_1	357809.Cphy_0179	1.128e-37	142.0	COG0640@1|root,COG0640@2|Bacteria,1VA3M@1239|Firmicutes,24NEC@186801|Clostridia,220IZ@1506553|Lachnoclostridium	186801|Clostridia	K	Helix-turn-helix domain	czrA	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD1_k127_2247250_1	1304284.L21TH_1762	6.357e-31	130.0	COG4863@1|root,COG4863@2|Bacteria,1V68T@1239|Firmicutes,24HB0@186801|Clostridia,36JEP@31979|Clostridiaceae	186801|Clostridia	S	YycH protein	-	-	-	-	-	-	-	-	-	-	-	-	YycH
HKD1_k127_2247250_0	1304284.L21TH_1763	5.194e-37	150.0	COG4853@1|root,COG4853@2|Bacteria,1VF8C@1239|Firmicutes,24MBB@186801|Clostridia,36K4Q@31979|Clostridiaceae	186801|Clostridia	S	YycH protein	-	-	-	-	-	-	-	-	-	-	-	-	YycI
HKD1_k127_2247684_0	290402.Cbei_0504	3.572e-30	136.0	COG4399@1|root,COG4399@2|Bacteria,1V3CY@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD1_k127_2279542_0	1009370.ALO_06015	2.415e-170	544.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,4H2CQ@909932|Negativicutes	909932|Negativicutes	C	aconitate hydratase	-	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD1_k127_2292813_1	1304284.L21TH_2209	3.194e-19	89.0	2E555@1|root,32ZY3@2|Bacteria,1VEM4@1239|Firmicutes,24QNR@186801|Clostridia,36MQ6@31979|Clostridiaceae	186801|Clostridia	S	Stage III sporulation protein AC	spoIIIAC	-	-	ko:K06392	-	-	-	-	ko00000	-	-	-	SpoIIIAC
HKD1_k127_2292813_0	1414720.CBYM010000008_gene1021	4.266e-46	171.0	COG3854@1|root,COG3854@2|Bacteria,1TQ23@1239|Firmicutes,248S2@186801|Clostridia,36E2F@31979|Clostridiaceae	186801|Clostridia	S	stage III sporulation protein AA	spoIIIAA	-	-	ko:K06390	-	-	-	-	ko00000	-	-	-	T2SSE
HKD1_k127_2295238_4	1121335.Clst_1718	4.765e-16	78.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,3WGUF@541000|Ruminococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_2295238_3	1408823.AXUS01000011_gene2012	4.797e-26	113.0	2DQ8Z@1|root,335CG@2|Bacteria,1V9R5@1239|Firmicutes,24JTW@186801|Clostridia,25RMX@186804|Peptostreptococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2295238_2	1031288.AXAA01000026_gene263	2.713e-42	162.0	COG0484@1|root,COG0484@2|Bacteria,1V6FQ@1239|Firmicutes,25F3F@186801|Clostridia,36UX4@31979|Clostridiaceae	186801|Clostridia	O	Molecular chaperone, DnaJ	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD1_k127_2295238_1	742723.HMPREF9477_01492	4.089e-76	264.0	2CC4I@1|root,2Z8PZ@2|Bacteria,1TQTT@1239|Firmicutes,24AJ3@186801|Clostridia,27J7I@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2295238_0	1408422.JHYF01000014_gene257	5.872e-92	309.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	cpsA	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_2309394_0	445335.CBN_0223	2.844e-115	379.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,36EJD@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_2309394_1	1499683.CCFF01000013_gene385	2.016e-77	263.0	COG1045@1|root,COG1045@2|Bacteria,1TR42@1239|Firmicutes,249SF@186801|Clostridia,36EH9@31979|Clostridiaceae	186801|Clostridia	E	Serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,SATase_N
HKD1_k127_2309394_2	1123009.AUID01000017_gene354	4.514e-09	57.0	COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia,26A6Y@186813|unclassified Clostridiales	186801|Clostridia	EG	GntP family permease	gntP	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
HKD1_k127_2314546_0	1034347.CAHJ01000054_gene163	4.229e-145	471.0	COG0366@1|root,COG0366@2|Bacteria,1TNZ0@1239|Firmicutes,4HB67@91061|Bacilli,1ZFG9@1386|Bacillus	91061|Bacilli	G	Alpha-amylase domain	malZ	-	3.2.1.20,3.2.1.41	ko:K01187,ko:K01200	ko00052,ko00500,ko01100,ko01110,map00052,map00500,map01100,map01110	-	R00028,R00801,R00802,R02111,R06087,R06088	RC00028,RC00049,RC00077	ko00000,ko00001,ko01000	-	CBM48,GH13,GH31	-	Alpha-amylase,Alpha-amylase_N
HKD1_k127_2330428_3	350688.Clos_1389	6.22e-10	63.0	COG1873@1|root,COG1873@2|Bacteria,1VEMT@1239|Firmicutes	1239|Firmicutes	S	sporulation protein, YlmC YmxH family	ylmC	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_2330428_0	2325.TKV_c15330	3.017e-111	364.0	COG1191@1|root,COG1191@2|Bacteria,1TPDD@1239|Firmicutes,24A1H@186801|Clostridia,42ENZ@68295|Thermoanaerobacterales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigG	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_2330428_1	1128398.Curi_c13090	3.609e-91	306.0	COG1191@1|root,COG1191@2|Bacteria,1TP3T@1239|Firmicutes,24A4T@186801|Clostridia,268I5@186813|unclassified Clostridiales	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigE	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HKD1_k127_2330428_2	203119.Cthe_0446	2.041e-13	78.0	29ECG@1|root,301AF@2|Bacteria,1UY4W@1239|Firmicutes,24HI3@186801|Clostridia,3WJPT@541000|Ruminococcaceae	186801|Clostridia	M	aspartic protease that is responsible for the proteolytic cleavage of the RNA polymerase sigma E factor (SigE spoIIGB) to yield the active peptide in the mother cell during sporulation. Responds to a signal from the forespore that is triggered by the extracellular signal protein SpoIIR	spoIIGA	-	-	ko:K06383	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_U4
HKD1_k127_2360358_0	500633.CLOHIR_01715	1.685e-187	591.0	COG0104@1|root,COG0104@2|Bacteria,1TQ4C@1239|Firmicutes,247RN@186801|Clostridia,25QZ5@186804|Peptostreptococcaceae	186801|Clostridia	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD1_k127_2372363_0	1304284.L21TH_1602	2.617e-159	519.0	COG2812@1|root,COG2812@2|Bacteria,1TPS9@1239|Firmicutes,247J7@186801|Clostridia,36DBN@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3
HKD1_k127_2372363_1	1540257.JQMW01000013_gene1152	6.043e-55	204.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,36FB9@31979|Clostridiaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_2372363_2	903814.ELI_3594	6.177e-40	153.0	COG0611@1|root,COG0611@2|Bacteria,1UHYE@1239|Firmicutes,248SP@186801|Clostridia	186801|Clostridia	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	-	-	-	-	-	-	-	-	-	-	-	-	AIRS
HKD1_k127_2378690_1	1354300.AUQY01000005_gene406	4.217e-23	99.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,22GK8@1570339|Peptoniphilaceae	186801|Clostridia	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_2378690_0	1347392.CCEZ01000007_gene2116	2.014e-135	437.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	thlA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_2380154_1	742741.HMPREF9475_00641	6.005e-40	153.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,2205F@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_2380154_0	1196322.A370_00272	1.588e-138	451.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_2380154_2	742741.HMPREF9475_00033	5.733e-36	138.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia	186801|Clostridia	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_2382143_0	203119.Cthe_1423	2.028e-104	349.0	COG0628@1|root,COG0628@2|Bacteria,1TQBF@1239|Firmicutes,25CCK@186801|Clostridia,3WHWD@541000|Ruminococcaceae	186801|Clostridia	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_244201_1	1230342.CTM_07511	6.974e-38	145.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,36DJV@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_244201_2	1031288.AXAA01000001_gene2342	3.991e-29	127.0	COG0454@1|root,COG0456@2|Bacteria,1VIZM@1239|Firmicutes,24E74@186801|Clostridia,36GC5@31979|Clostridiaceae	186801|Clostridia	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_244201_0	857293.CAAU_0543	9.494e-44	166.0	COG0789@1|root,COG0789@2|Bacteria	2|Bacteria	K	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1,TipAS
HKD1_k127_2447766_2	1069080.KB913028_gene939	1.05e-06	51.0	COG0038@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0569@2|Bacteria,1TPX0@1239|Firmicutes,4H3PC@909932|Negativicutes	909932|Negativicutes	P	Chloride transporter ClC family	clcA	-	-	-	-	-	-	-	-	-	-	-	TrkA_C,Voltage_CLC
HKD1_k127_2447766_1	1158602.I590_01726	2.401e-37	145.0	COG1765@1|root,COG1765@2|Bacteria,1V6ZU@1239|Firmicutes,4HJ3I@91061|Bacilli,4B6N3@81852|Enterococcaceae	91061|Bacilli	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD1_k127_2447766_0	865861.AZSU01000001_gene498	1.232e-172	547.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_2448655_1	1304866.K413DRAFT_2045	1.73e-40	153.0	COG1975@1|root,COG1975@2|Bacteria,1UZDB@1239|Firmicutes,25D6N@186801|Clostridia,36U7S@31979|Clostridiaceae	186801|Clostridia	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD1_k127_2448655_0	1121289.JHVL01000050_gene2015	1.364e-59	221.0	COG2068@1|root,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,36FU4@31979|Clostridiaceae	186801|Clostridia	S	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
HKD1_k127_2448655_2	1121115.AXVN01000001_gene1047	7.175e-24	101.0	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,3XZT8@572511|Blautia	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	moeA2	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_2448655_3	1345695.CLSA_c26480	5.198e-15	74.0	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,36DBJ@31979|Clostridiaceae	186801|Clostridia	H	molybdopterin binding domain	moeA2	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_2449784_4	1321778.HMPREF1982_03787	2.249e-21	95.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia	186801|Clostridia	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_2449784_0	1105031.HMPREF1141_0051	2.486e-199	630.0	COG2851@1|root,COG2851@2|Bacteria,1TQQH@1239|Firmicutes,24A61@186801|Clostridia,36FUA@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM citrate H symporter, CitMHS family	citN	-	-	ko:K03300	-	-	-	-	ko00000	2.A.11	-	-	CitMHS
HKD1_k127_2449784_2	1410668.JNKC01000012_gene1088	1.604e-132	431.0	COG3053@1|root,COG3053@2|Bacteria,1TSGQ@1239|Firmicutes,248Y4@186801|Clostridia,36EF0@31979|Clostridiaceae	186801|Clostridia	C	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase	citC	-	6.2.1.22	ko:K01910	ko02020,map02020	-	R04449	RC00012,RC00039	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Citrate_ly_lig
HKD1_k127_2449784_3	536227.CcarbDRAFT_1888	1.782e-24	106.0	COG3052@1|root,COG3052@2|Bacteria,1VEZZ@1239|Firmicutes,24QMJ@186801|Clostridia,36N6K@31979|Clostridiaceae	186801|Clostridia	C	Covalent carrier of the coenzyme of citrate lyase	citD	-	-	ko:K01646	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001	-	-	-	ACP
HKD1_k127_2449784_1	1410668.JNKC01000012_gene1086	1.487e-142	456.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,36E49@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS12480	HpcH_HpaI,Malate_synthase
HKD1_k127_2456159_2	203119.Cthe_1295	1.655e-39	153.0	COG0212@1|root,COG0212@2|Bacteria,1VA91@1239|Firmicutes,24N7H@186801|Clostridia,3WJKP@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family	fthC	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD1_k127_2456159_1	1304284.L21TH_2579	1.537e-54	200.0	COG1040@1|root,COG1040@2|Bacteria,1VF2G@1239|Firmicutes,24IG6@186801|Clostridia,36IPK@31979|Clostridiaceae	186801|Clostridia	S	ComF family	comF	-	-	ko:K02242	-	M00429	-	-	ko00000,ko00002,ko02044	-	-	-	Pribosyltran
HKD1_k127_2456159_0	1304284.L21TH_2580	9.606e-262	826.0	COG0507@1|root,COG0507@2|Bacteria,1TPZH@1239|Firmicutes,247R7@186801|Clostridia,36ER3@31979|Clostridiaceae	186801|Clostridia	L	DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity	recD2	-	3.1.11.5	ko:K03581	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_30,HHH_4,HHH_5,UvrD_C_2
HKD1_k127_2456159_3	1304284.L21TH_1646	2.829e-31	125.0	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,36FTH@31979|Clostridiaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_24621_0	1345695.CLSA_c24270	6.967e-103	340.0	arCOG08608@1|root,32CXY@2|Bacteria,1V6CC@1239|Firmicutes,24AQP@186801|Clostridia,36EBJ@31979|Clostridiaceae	186801|Clostridia	S	phospholipase C	-	-	3.1.4.3	ko:K01114	ko00562,ko00564,ko00565,ko01100,ko01110,ko02024,ko04919,map00562,map00564,map00565,map01100,map01110,map02024,map04919	-	R01312,R02027,R02052,R03332,R07381	RC00017,RC00425	ko00000,ko00001,ko01000,ko02042	-	-	-	Zn_dep_PLPC
HKD1_k127_24621_4	908340.HMPREF9406_2054	4.314e-08	55.0	COG1793@1|root,COG1793@2|Bacteria,1U8ME@1239|Firmicutes,24B1F@186801|Clostridia,36IWZ@31979|Clostridiaceae	186801|Clostridia	L	PFAM ATP dependent DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD1_k127_24621_3	1408823.AXUS01000024_gene2743	1.311e-10	62.0	COG1793@1|root,COG1793@2|Bacteria,1U8ME@1239|Firmicutes,24B1F@186801|Clostridia	186801|Clostridia	L	PFAM ATP dependent DNA ligase	lig	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K01971,ko:K10747	ko03030,ko03410,ko03420,ko03430,ko03450,map03030,map03410,map03420,map03430,map03450	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD1_k127_24621_1	642492.Clole_3115	1.193e-87	297.0	COG5036@1|root,COG5036@2|Bacteria,1V1FZ@1239|Firmicutes,24FRH@186801|Clostridia	186801|Clostridia	P	VTC domain	-	-	-	-	-	-	-	-	-	-	-	-	VTC
HKD1_k127_24621_2	767817.Desgi_4258	8.687e-37	143.0	COG1285@1|root,COG1285@2|Bacteria,1V1GI@1239|Firmicutes,24G1I@186801|Clostridia,261H5@186807|Peptococcaceae	186801|Clostridia	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
HKD1_k127_246879_1	1347392.CCEZ01000074_gene1917	0.0001163	49.0	COG1397@1|root,COG1397@2|Bacteria,1V4ES@1239|Firmicutes,24HTU@186801|Clostridia,36IZG@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_246879_0	1347392.CCEZ01000074_gene1919	3.784e-154	502.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,36DF6@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
HKD1_k127_2495331_3	519441.Smon_0554	0.000158	44.0	COG2313@1|root,COG2313@2|Bacteria,379S0@32066|Fusobacteria	32066|Fusobacteria	H	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
HKD1_k127_2495331_0	350688.Clos_0651	2.417e-158	506.0	COG0524@1|root,COG1846@1|root,COG0524@2|Bacteria,COG1846@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,36F1Z@31979|Clostridiaceae	186801|Clostridia	G	hmm pf00294	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
HKD1_k127_2495331_1	416591.Tlet_1577	5.73e-42	160.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_5
HKD1_k127_2495331_2	97138.C820_02713	1.713e-25	116.0	COG0265@1|root,COG0265@2|Bacteria,1UZ8K@1239|Firmicutes,24N2F@186801|Clostridia,36NDF@31979|Clostridiaceae	186801|Clostridia	O	Trypsin	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	Cu_amine_oxidN1,DUF5050,RsgI_N,Trypsin_2
HKD1_k127_2523058_1	352165.HMPREF7215_0195	1.091e-46	175.0	COG0378@1|root,COG0378@2|Bacteria,3TAUU@508458|Synergistetes	508458|Synergistetes	KO	Hydrogenase accessory protein HypB	hypB	-	-	ko:K04652	-	-	-	-	ko00000,ko03110	-	-	-	cobW
HKD1_k127_2523058_0	203119.Cthe_3016	2.598e-144	464.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,3WHQ8@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD1_k127_2528246_2	1449050.JNLE01000003_gene2282	3.676e-184	587.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,36DQ7@31979|Clostridiaceae	186801|Clostridia	C	L-lactate permease	lctP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HKD1_k127_2528246_3	1449050.JNLE01000003_gene2281	9.755e-88	295.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24GA8@186801|Clostridia,36F6A@31979|Clostridiaceae	186801|Clostridia	K	GntR domain protein	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD1_k127_2528246_5	1151292.QEW_1448	2.95e-64	224.0	COG2606@1|root,COG2606@2|Bacteria,1V3MU@1239|Firmicutes,24HH2@186801|Clostridia,25RMS@186804|Peptostreptococcaceae	186801|Clostridia	S	YbaK proline--tRNA ligase associated domain protein	EbsC	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD1_k127_2528246_1	1131462.DCF50_p2824	5.043e-235	745.0	COG3808@1|root,COG3808@2|Bacteria,1TNZI@1239|Firmicutes,248KS@186801|Clostridia,260WE@186807|Peptococcaceae	186801|Clostridia	C	Sodium pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for Na( ) movement across the membrane	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD1_k127_2528246_4	573061.Clocel_1812	8.73e-86	290.0	COG1180@1|root,COG1180@2|Bacteria,1TPK2@1239|Firmicutes,247NA@186801|Clostridia,36EN2@31979|Clostridiaceae	186801|Clostridia	C	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine	pflA	-	1.97.1.4	ko:K04069	-	-	R04710	-	ko00000,ko01000	-	-	-	Fer4_12,Radical_SAM
HKD1_k127_2528246_0	1304284.L21TH_0772	0.0	1095.0	COG1882@1|root,COG1882@2|Bacteria,1TPTF@1239|Firmicutes,247YY@186801|Clostridia,36F8M@31979|Clostridiaceae	186801|Clostridia	C	formate acetyltransferase	pflB	-	2.3.1.54	ko:K00656	ko00620,ko00640,ko00650,ko01100,ko01120,map00620,map00640,map00650,map01100,map01120	-	R00212,R06987	RC00004,RC01181,RC02742,RC02833	ko00000,ko00001,ko01000	-	-	-	Gly_radical,PFL-like
HKD1_k127_2528246_6	1168034.FH5T_14770	2.353e-09	65.0	COG3064@1|root,COG3064@2|Bacteria,4NUAK@976|Bacteroidetes	976|Bacteroidetes	M	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2529053_1	1471459.JFLJ01000084_gene609	5.114e-13	78.0	COG2894@1|root,COG2894@2|Bacteria,1G2A5@1117|Cyanobacteria,1MM4V@1212|Prochloraceae	1117|Cyanobacteria	D	Belongs to the ParA family	minD	GO:0000910,GO:0007049,GO:0008150,GO:0009987,GO:0022402,GO:0032506,GO:0036214,GO:0051179,GO:0051301,GO:0061640	-	ko:K03609	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31,CbiA,ParA
HKD1_k127_2529053_0	1304284.L21TH_2129	6.1e-159	514.0	COG0768@1|root,COG0768@2|Bacteria,1TQHY@1239|Firmicutes,2480Z@186801|Clostridia,36DW0@31979|Clostridiaceae	186801|Clostridia	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD1_k127_25363_1	994573.T472_0206925	1.564e-17	84.0	COG2721@1|root,COG2721@2|Bacteria,1VFEZ@1239|Firmicutes,24UG5@186801|Clostridia,36PCE@31979|Clostridiaceae	186801|Clostridia	G	SAF	-	-	4.2.1.7	ko:K16849	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	SAF
HKD1_k127_25363_0	994573.T472_0206920	8.027e-139	445.0	COG2721@1|root,COG2721@2|Bacteria,1TPTX@1239|Firmicutes,24AEC@186801|Clostridia,36G4P@31979|Clostridiaceae	186801|Clostridia	G	D-galactarate dehydratase altronate hydrolase	-	-	4.2.1.7	ko:K16850	ko00040,ko01100,map00040,map01100	M00631	R01540	RC00543	ko00000,ko00001,ko00002,ko01000	-	-	-	GD_AH_C
HKD1_k127_2565691_0	1123009.AUID01000001_gene1110	3.566e-192	607.0	COG1228@1|root,COG1228@2|Bacteria,1TP2J@1239|Firmicutes,24AGR@186801|Clostridia,269ZF@186813|unclassified Clostridiales	186801|Clostridia	Q	Amidohydrolase family	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_2565691_1	1122975.AQVC01000003_gene1359	5.831e-37	143.0	COG3404@1|root,COG3404@2|Bacteria,4NN2J@976|Bacteroidetes,2FPSN@200643|Bacteroidia,22XZX@171551|Porphyromonadaceae	976|Bacteroidetes	E	Methenyltetrahydrofolate cyclohydrolase	fchA	-	-	-	-	-	-	-	-	-	-	-	FTCD_C,Peptidase_M78
HKD1_k127_2567844_1	1120998.AUFC01000023_gene2196	1.768e-17	88.0	2E9V5@1|root,33410@2|Bacteria,1VEQY@1239|Firmicutes,24J21@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4860)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4860
HKD1_k127_2567844_0	1211844.CBLM010000027_gene1950	6.818e-109	359.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,3VPQY@526524|Erysipelotrichia	526524|Erysipelotrichia	NU	type II secretion pathway protein E K01509	-	-	-	-	-	-	-	-	-	-	-	-	T2SSE
HKD1_k127_258009_1	536227.CcarbDRAFT_1912	4.288e-216	675.0	COG0426@1|root,COG0426@2|Bacteria,1TQE9@1239|Firmicutes,249CU@186801|Clostridia,36E70@31979|Clostridiaceae	186801|Clostridia	C	flavodoxin nitric oxide synthase	norV	-	1.6.3.4	ko:K22405	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_1,Lactamase_B
HKD1_k127_258009_3	1120746.CCNL01000017_gene2403	9.142e-110	362.0	COG1893@1|root,COG1893@2|Bacteria	2|Bacteria	H	2-dehydropantoate 2-reductase activity	panE	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_258009_2	1449050.JNLE01000003_gene3494	1.708e-150	478.0	COG1586@1|root,COG1586@2|Bacteria,1TQ7S@1239|Firmicutes,2480M@186801|Clostridia,36ET4@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine	speD	-	4.1.1.50	ko:K01611	ko00270,ko00330,ko01100,map00270,map00330,map01100	M00034,M00133	R00178	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	AdoMet_dc
HKD1_k127_258009_0	1122173.AXVL01000019_gene2305	3.527e-243	758.0	COG1982@1|root,COG1982@2|Bacteria,379MA@32066|Fusobacteria	32066|Fusobacteria	E	Psort location Cytoplasmic, score	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase,OKR_DC_1,OKR_DC_1_C
HKD1_k127_258009_4	1449050.JNLE01000003_gene3492	7.891e-35	134.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,36FAN@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HKD1_k127_2585204_6	1211817.CCAT010000086_gene2390	1.36e-06	50.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,36EMT@31979|Clostridiaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
HKD1_k127_2585204_4	1304284.L21TH_0868	1.783e-25	105.0	COG2768@1|root,COG2768@2|Bacteria,1VET2@1239|Firmicutes,24QUH@186801|Clostridia,36MIM@31979|Clostridiaceae	186801|Clostridia	C	Ferredoxin	fdxA	GO:0003674,GO:0003824,GO:0005488,GO:0006091,GO:0008150,GO:0008152,GO:0009055,GO:0009987,GO:0016491,GO:0022900,GO:0044237,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0055114	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_2585204_0	1304284.L21TH_0867	9.705e-118	385.0	COG1774@1|root,COG1774@2|Bacteria,1TP1V@1239|Firmicutes,247Q6@186801|Clostridia,36EJN@31979|Clostridiaceae	186801|Clostridia	S	PSP1 domain protein	yaaT	-	-	-	-	-	-	-	-	-	-	-	PSP1
HKD1_k127_2585204_1	1304284.L21TH_0866	9.069e-77	268.0	COG2812@1|root,COG2812@2|Bacteria,1VCQC@1239|Firmicutes,248U4@186801|Clostridia,36UHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNApol3-delta_C
HKD1_k127_2585204_3	521460.Athe_0513	1.974e-29	120.0	COG3870@1|root,COG3870@2|Bacteria,1V6NI@1239|Firmicutes,24N37@186801|Clostridia,42GU4@68295|Thermoanaerobacterales	186801|Clostridia	S	Cyclic-di-AMP receptor	yaaQ	-	-	-	-	-	-	-	-	-	-	-	CdAMP_rec
HKD1_k127_2585204_2	1128398.Curi_c01110	2.87e-71	246.0	COG0125@1|root,COG0125@2|Bacteria,1V1HE@1239|Firmicutes,24HHC@186801|Clostridia,26B2H@186813|unclassified Clostridiales	186801|Clostridia	F	Thymidylate kinase	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD1_k127_2585204_5	457396.CSBG_01252	7.29e-14	75.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,36DPH@31979|Clostridiaceae	186801|Clostridia	E	Orn Lys Arg decarboxylase major	speA	-	4.1.1.19	ko:K01585	ko00330,ko01100,map00330,map01100	M00133	R00566	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HKD1_k127_2611312_0	1304284.L21TH_0650	2.746e-114	375.0	COG0564@1|root,COG0564@2|Bacteria,1TPCM@1239|Firmicutes,247Y2@186801|Clostridia,36EAK@31979|Clostridiaceae	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_2611312_1	1476973.JMMB01000007_gene909	8.071e-67	231.0	COG2065@1|root,COG2065@2|Bacteria,1V3GV@1239|Firmicutes,24FQD@186801|Clostridia,25RCD@186804|Peptostreptococcaceae	186801|Clostridia	F	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant	pyrR	-	2.4.2.9	ko:K02825	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000,ko03000	-	-	iHN637.CLJU_RS05275	Pribosyltran
HKD1_k127_2611312_2	235909.GK2913	0.000132	48.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,4HD6Z@91061|Bacilli,1WH5P@129337|Geobacillus	91061|Bacilli	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_int_SAM_4,Phage_int_SAM_5,Phage_integrase
HKD1_k127_2653160_2	293826.Amet_2404	0.0002323	46.0	2ESIT@1|root,33K3H@2|Bacteria,1VNX8@1239|Firmicutes,24V0F@186801|Clostridia,36TAX@31979|Clostridiaceae	186801|Clostridia	S	PFAM small acid-soluble spore protein alpha beta type	-	-	-	ko:K06421	-	-	-	-	ko00000	-	-	-	SASP
HKD1_k127_2653160_0	1304284.L21TH_1636	5.303e-64	230.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,36FHF@31979|Clostridiaceae	186801|Clostridia	K	cell envelope-related function transcriptional attenuator	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD1_k127_2653160_1	1128398.Curi_c01270	1.634e-55	199.0	COG0030@1|root,COG0030@2|Bacteria,1TP9W@1239|Firmicutes,248RY@186801|Clostridia,268IU@186813|unclassified Clostridiales	186801|Clostridia	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD1_k127_2655485_1	1304284.L21TH_1665	1.804e-10	61.0	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,36E8N@31979|Clostridiaceae	186801|Clostridia	M	family 18	-	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
HKD1_k127_2655485_0	1304284.L21TH_1684	1.599e-41	167.0	COG3087@1|root,COG3087@2|Bacteria,1V30Z@1239|Firmicutes,249SI@186801|Clostridia,36DPU@31979|Clostridiaceae	186801|Clostridia	D	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2683143_0	1304284.L21TH_1408	3.49e-229	722.0	COG1615@1|root,COG1615@2|Bacteria,1TQHM@1239|Firmicutes,248PM@186801|Clostridia,36DY1@31979|Clostridiaceae	186801|Clostridia	S	UPF0182 protein	-	-	-	ko:K09118	-	-	-	-	ko00000	-	-	-	UPF0182
HKD1_k127_2686853_1	1292035.H476_3132	1.156e-160	520.0	COG0007@1|root,COG1587@1|root,COG0007@2|Bacteria,COG1587@2|Bacteria,1TQNH@1239|Firmicutes,2487I@186801|Clostridia,25QIP@186804|Peptostreptococcaceae	186801|Clostridia	H	Belongs to the precorrin methyltransferase family	cobA	-	1.3.1.76,2.1.1.107,4.2.1.75,4.99.1.4	ko:K02302,ko:K02303,ko:K13542	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02864,R03165,R03194,R03947	RC00003,RC00871,RC01012,RC01034,RC01861	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15755	HEM4,Porphobil_deam,Porphobil_deamC,TP_methylase
HKD1_k127_2686853_2	929506.CbC4_2010	1.062e-140	453.0	COG0113@1|root,COG0113@2|Bacteria,1TP09@1239|Firmicutes,2496V@186801|Clostridia,36ERT@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD1_k127_2686853_0	1511.CLOST_1001	5.009e-182	578.0	COG0001@1|root,COG0001@2|Bacteria,1TPNH@1239|Firmicutes,248II@186801|Clostridia,25R8B@186804|Peptostreptococcaceae	186801|Clostridia	H	Aminotransferase class-III	hemL	-	5.4.3.8	ko:K01845	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R02272	RC00677	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_2686853_3	1347392.CCEZ01000019_gene961	2.651e-48	182.0	COG4822@1|root,COG4822@2|Bacteria,1TQ5V@1239|Firmicutes,24ABG@186801|Clostridia,36DQD@31979|Clostridiaceae	186801|Clostridia	H	sirohydrochlorin cobaltochelatase	cbiK	-	4.99.1.3	ko:K02190	ko00860,ko01100,map00860,map01100	-	R05807	RC01012	ko00000,ko00001,ko01000	-	-	-	CbiK
HKD1_k127_2686853_4	869213.JCM21142_42031	8.775e-32	125.0	COG2158@1|root,COG2158@2|Bacteria	2|Bacteria	S	Cysteine-rich small domain	cbiA	-	-	ko:K07162	-	-	-	-	ko00000	-	-	-	zf-like
HKD1_k127_2692063_0	1304284.L21TH_0694	2.256e-74	256.0	COG0571@1|root,COG0571@2|Bacteria,1TPGC@1239|Firmicutes,249QD@186801|Clostridia,36FEP@31979|Clostridiaceae	186801|Clostridia	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD1_k127_2692063_1	1321778.HMPREF1982_02039	1.242e-26	111.0	COG1243@1|root,COG1243@2|Bacteria,1TS1F@1239|Firmicutes,248YV@186801|Clostridia,268SX@186813|unclassified Clostridiales	186801|Clostridia	BK	Radical_SAM C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,Radical_SAM_C
HKD1_k127_2692783_5	1128398.Curi_c23770	6.039e-27	111.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia,269AG@186813|unclassified Clostridiales	186801|Clostridia	J	S4 RNA-binding domain	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
HKD1_k127_2692783_1	1304284.L21TH_0153	2.079e-170	540.0	COG0216@1|root,COG0216@2|Bacteria,1TQ7V@1239|Firmicutes,248CN@186801|Clostridia,36DYV@31979|Clostridiaceae	186801|Clostridia	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_2692783_3	1121289.JHVL01000001_gene1840	1.833e-78	271.0	COG2890@1|root,COG2890@2|Bacteria,1TSMA@1239|Firmicutes,24838@186801|Clostridia,36EJF@31979|Clostridiaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD1_k127_2692783_2	1304284.L21TH_0157	7.212e-115	378.0	COG3872@1|root,COG3872@2|Bacteria,1TPBU@1239|Firmicutes,25C8E@186801|Clostridia,36FM3@31979|Clostridiaceae	186801|Clostridia	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	-	-	-	-	-	-	-	-	-	-	DUF1385,MTS
HKD1_k127_2692783_4	428125.CLOLEP_01626	1.093e-36	143.0	COG0782@1|root,COG0782@2|Bacteria,1V44S@1239|Firmicutes,24HP9@186801|Clostridia,3WIJW@541000|Ruminococcaceae	186801|Clostridia	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD1_k127_2692783_0	1120998.AUFC01000008_gene1103	1.161e-262	831.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_2694786_1	1304284.L21TH_0212	2.479e-96	316.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,36F7D@31979|Clostridiaceae	186801|Clostridia	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
HKD1_k127_2694786_0	1304284.L21TH_0211	3.423e-129	415.0	COG5012@1|root,COG5012@2|Bacteria,1UJB2@1239|Firmicutes,25F0A@186801|Clostridia,36EPZ@31979|Clostridiaceae	186801|Clostridia	S	Dimerisation domain of d-ornithine 4,5-aminomutase	-	-	5.4.3.3	ko:K18011	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,OAM_dimer
HKD1_k127_2704514_2	868595.Desca_1921	4.549e-85	286.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,2602Q@186807|Peptococcaceae	186801|Clostridia	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD1_k127_2704514_1	696369.KI912183_gene37	3.453e-87	295.0	COG0619@1|root,COG0619@2|Bacteria,1U6XW@1239|Firmicutes,24EV0@186801|Clostridia,26197@186807|Peptococcaceae	186801|Clostridia	P	Cobalt ABC transporter, permease protein CbiQ	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD1_k127_2704514_0	1449126.JQKL01000006_gene825	4.864e-125	410.0	COG0310@1|root,COG0310@2|Bacteria,1TPEN@1239|Firmicutes,248S9@186801|Clostridia	186801|Clostridia	P	PFAM cobalamin (vitamin B12) biosynthesis CbiM	cbiM2	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM,PDGLE
HKD1_k127_2713488_0	1123009.AUID01000001_gene1006	4.521e-319	984.0	COG0495@1|root,COG0495@2|Bacteria,1TP0Y@1239|Firmicutes,2484Y@186801|Clostridia,2687P@186813|unclassified Clostridiales	186801|Clostridia	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD1_k127_2718134_1	1304284.L21TH_2168	2.395e-58	210.0	COG0286@1|root,COG0286@2|Bacteria,1UMSN@1239|Firmicutes,24856@186801|Clostridia,36F0V@31979|Clostridiaceae	186801|Clostridia	V	TaqI-like C-terminal specificity domain	-	-	2.1.1.72	ko:K07317	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	Eco57I,N6_Mtase,TaqI_C
HKD1_k127_2718134_0	1304284.L21TH_2170	5.148e-91	319.0	COG2273@1|root,COG2273@2|Bacteria	2|Bacteria	G	xyloglucan:xyloglucosyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_16
HKD1_k127_2718241_0	537013.CLOSTMETH_00827	1.763e-133	433.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3WHCK@541000|Ruminococcaceae	186801|Clostridia	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
HKD1_k127_2719198_1	1121335.Clst_0657	1.486e-79	270.0	COG1055@1|root,COG1055@2|Bacteria,1TPNN@1239|Firmicutes,2494X@186801|Clostridia,3WIGS@541000|Ruminococcaceae	186801|Clostridia	P	Arsenical pump membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD1_k127_2719198_0	476272.RUMHYD_01534	9.704e-84	281.0	COG3048@1|root,COG3048@2|Bacteria,1TPAH@1239|Firmicutes,249NA@186801|Clostridia	186801|Clostridia	E	Belongs to the serine threonine dehydratase family. DsdA subfamily	dsdA	-	4.3.1.18	ko:K01753	ko00260,map00260	-	R00221	RC02600	ko00000,ko00001,ko01000	-	-	-	PALP
HKD1_k127_2721561_1	1304284.L21TH_0633	4.354e-113	374.0	COG1625@1|root,COG1625@2|Bacteria,1TSFU@1239|Firmicutes,247JK@186801|Clostridia,36EMT@31979|Clostridiaceae	186801|Clostridia	C	Fe-S oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DUF512
HKD1_k127_2721561_0	1304284.L21TH_0634	6.193e-186	590.0	COG1160@1|root,COG1160@2|Bacteria,1TPNM@1239|Firmicutes,2493T@186801|Clostridia,36DFQ@31979|Clostridiaceae	186801|Clostridia	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD1_k127_2721561_2	1128398.Curi_c17150	1.839e-56	202.0	COG0344@1|root,COG0344@2|Bacteria,1VA3J@1239|Firmicutes,24JA2@186801|Clostridia,268D4@186813|unclassified Clostridiales	186801|Clostridia	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD1_k127_2723882_0	445335.CBN_0250	4.843e-164	529.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,36E8U@31979|Clostridiaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD1_k127_2723882_1	1304284.L21TH_1209	2.848e-136	443.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,248CR@186801|Clostridia,36DR8@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_2723882_2	1121289.JHVL01000035_gene2637	1.531e-35	137.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,36UHR@31979|Clostridiaceae	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_2724574_1	1304284.L21TH_2295	5.189e-65	229.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,248QP@186801|Clostridia,36DCW@31979|Clostridiaceae	186801|Clostridia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9,2.7.9.2	ko:K01007,ko:K08483	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,ko02060,map00620,map00680,map00720,map01100,map01120,map01200,map02060	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_2724574_2	536227.CcarbDRAFT_2016	2.147e-55	194.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_2724574_0	536227.CcarbDRAFT_2016	4.108e-223	694.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_2737389_2	1123009.AUID01000020_gene140	7.943e-06	48.0	COG0454@1|root,COG0456@2|Bacteria,1V4PA@1239|Firmicutes,25BRJ@186801|Clostridia	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1
HKD1_k127_2737389_1	318464.IO99_08020	9.296e-61	222.0	2E3R1@1|root,32YNU@2|Bacteria,1VEND@1239|Firmicutes,24RRZ@186801|Clostridia,36UVR@31979|Clostridiaceae	186801|Clostridia	S	Anti-sigma factor N-terminus	-	-	-	-	-	-	-	-	-	-	-	-	RsgI_N
HKD1_k127_2737389_0	1120746.CCNL01000017_gene2697	1.088e-68	241.0	COG1191@1|root,COG1191@2|Bacteria	2|Bacteria	K	sigma factor activity	sigI	-	-	ko:K03091,ko:K03093	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
HKD1_k127_2737539_0	931626.Awo_c10570	4.138e-114	370.0	COG0489@1|root,COG1433@1|root,COG0489@2|Bacteria,COG1433@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,25VN4@186806|Eubacteriaceae	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	-	-	-	-	-	-	-	-	-	ParA
HKD1_k127_2737539_1	1128398.Curi_c29280	5.997e-20	92.0	29795@1|root,2ZUGV@2|Bacteria,1W2MR@1239|Firmicutes,24VAT@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_2737539_2	1230342.CTM_10231	1.839e-14	74.0	COG1633@1|root,COG1633@2|Bacteria,1V860@1239|Firmicutes,24ERW@186801|Clostridia,36EYA@31979|Clostridiaceae	186801|Clostridia	G	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_2738975_0	1007096.BAGW01000010_gene2189	3.388e-134	455.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,2N74Y@216572|Oscillospiraceae	186801|Clostridia	NT	Cache domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
HKD1_k127_2738975_1	1120746.CCNL01000011_gene1510	2.904e-86	300.0	COG0840@1|root,COG0840@2|Bacteria,2NQS9@2323|unclassified Bacteria	2|Bacteria	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1,sCache_2
HKD1_k127_2741678_0	1499683.CCFF01000017_gene2723	2.208e-87	300.0	COG2603@1|root,COG2603@2|Bacteria,1TQ8T@1239|Firmicutes,24AM7@186801|Clostridia,36GE2@31979|Clostridiaceae	186801|Clostridia	S	Rhodanese Homology Domain	selU	-	-	ko:K06917	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Rhodanese
HKD1_k127_2762375_0	1121289.JHVL01000001_gene1894	3.35e-115	374.0	COG1063@1|root,COG1063@2|Bacteria,1UJB1@1239|Firmicutes,25F09@186801|Clostridia,36UVA@31979|Clostridiaceae	186801|Clostridia	E	alcohol dehydrogenase	-	-	1.4.1.11	ko:K18012	ko00310,map00310	-	R03349	RC00888	ko00000,ko00001,ko01000	-	-	-	ADH_zinc_N
HKD1_k127_2762375_1	1128398.Curi_c01610	7.181e-56	197.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,268TM@186813|unclassified Clostridiales	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD1_k127_2803509_0	1443125.Z962_01330	7.514e-81	274.0	COG2339@1|root,COG2339@2|Bacteria,1UZGQ@1239|Firmicutes,24D4U@186801|Clostridia,36G8M@31979|Clostridiaceae	186801|Clostridia	S	Protease prsW family	prsW	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD1_k127_2824815_1	1292035.H476_2095	4.517e-61	215.0	COG0707@1|root,COG0707@2|Bacteria,1TQFT@1239|Firmicutes,248IA@186801|Clostridia,25R4M@186804|Peptostreptococcaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD1_k127_2824815_0	1128398.Curi_c13000	1.008e-79	272.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,2682V@186813|unclassified Clostridiales	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_2826279_1	720554.Clocl_2606	6.441e-76	259.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,3WGPN@541000|Ruminococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_2826279_0	1347392.CCEZ01000044_gene670	2.064e-103	347.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,36EA5@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HKD1_k127_2843667_1	642492.Clole_4008	1.54e-40	154.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
HKD1_k127_2843667_0	1235835.C814_00314	1.417e-85	291.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,3WIFV@541000|Ruminococcaceae	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_2846901_0	1120746.CCNL01000011_gene1481	2.458e-48	183.0	COG1360@1|root,COG1360@2|Bacteria,2NRCZ@2323|unclassified Bacteria	2|Bacteria	N	Membrane MotB of proton-channel complex MotA/MotB	motB	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HKD1_k127_2846901_1	1121334.KB911069_gene1601	7.933e-29	119.0	COG1868@1|root,COG1868@2|Bacteria,1TPTM@1239|Firmicutes,24AGV@186801|Clostridia,3WIQE@541000|Ruminococcaceae	186801|Clostridia	N	flagellar motor switch protein	fliM	-	-	ko:K02416	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliM,FliMN_C
HKD1_k127_2880147_2	857293.CAAU_1671	4.904e-44	163.0	COG0335@1|root,COG0335@2|Bacteria,1V6FT@1239|Firmicutes,24J83@186801|Clostridia,36JJ4@31979|Clostridiaceae	186801|Clostridia	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD1_k127_2880147_0	1304284.L21TH_0979	1.325e-91	306.0	COG0336@1|root,COG0336@2|Bacteria,1TPBV@1239|Firmicutes,247JF@186801|Clostridia,36EJ7@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD1_k127_2880147_3	1304284.L21TH_0980	9.494e-44	166.0	COG0806@1|root,COG0806@2|Bacteria,1V6HD@1239|Firmicutes,24I1G@186801|Clostridia,36IPC@31979|Clostridiaceae	186801|Clostridia	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD1_k127_2880147_5	1304284.L21TH_0981	4.134e-34	132.0	COG1837@1|root,COG1837@2|Bacteria,1VEG7@1239|Firmicutes,24QKN@186801|Clostridia,36KGX@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0109 family	ylqC	-	-	ko:K06960	-	-	-	-	ko00000	-	-	-	KH_4
HKD1_k127_2880147_4	1121289.JHVL01000003_gene2250	1.028e-39	148.0	COG0228@1|root,COG0228@2|Bacteria,1VA0X@1239|Firmicutes,24MND@186801|Clostridia,36KP2@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD1_k127_2880147_1	457570.Nther_1368	5.672e-47	173.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_2883336_0	1321784.HMPREF1987_01263	8.333e-110	370.0	COG0591@1|root,COG0591@2|Bacteria,1TQEZ@1239|Firmicutes,24AJN@186801|Clostridia,25T2R@186804|Peptostreptococcaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD1_k127_2883336_1	865861.AZSU01000003_gene1916	7.821e-70	240.0	COG2256@1|root,COG2256@2|Bacteria,1TPVV@1239|Firmicutes,247X2@186801|Clostridia,36EXD@31979|Clostridiaceae	186801|Clostridia	L	AAA ATPase	rarA	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD1_k127_290112_0	642492.Clole_1364	9.801e-135	434.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	ntpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD1_k127_2902547_0	1232447.BAHW02000023_gene1543	3.438e-79	279.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,248MN@186801|Clostridia,269C3@186813|unclassified Clostridiales	186801|Clostridia	G	Bacterial extracellular solute-binding protein, family 7	siaP	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_298072_0	1034347.CAHJ01000029_gene3705	1.038e-78	273.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,4HB06@91061|Bacilli,1ZCM3@1386|Bacillus	91061|Bacilli	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD1_k127_3007590_1	1321778.HMPREF1982_01107	1.103e-42	160.0	COG1142@1|root,COG4624@1|root,COG1142@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,2688B@186813|unclassified Clostridiales	186801|Clostridia	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	1.12.7.2	ko:K00533	-	-	R00019	-	ko00000,ko01000	-	-	-	Fe_hyd_lg_C,Fer4
HKD1_k127_3007590_0	1304284.L21TH_0543	2.089e-100	336.0	COG2208@1|root,COG2208@2|Bacteria,1TQUC@1239|Firmicutes,248FZ@186801|Clostridia,36FUJ@31979|Clostridiaceae	186801|Clostridia	KT	stage II sporulation	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIE
HKD1_k127_3012168_2	1301100.HG529321_gene6094	1.151e-17	83.0	COG1540@1|root,COG1540@2|Bacteria,1TR8X@1239|Firmicutes,249GD@186801|Clostridia,36ERA@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0271 (lamB) family	-	-	-	ko:K07160	-	-	-	-	ko00000	-	-	-	LamB_YcsF
HKD1_k127_3012168_0	1408287.AXUR01000027_gene159	1.48e-156	503.0	COG1914@1|root,COG1914@2|Bacteria,378T8@32066|Fusobacteria	32066|Fusobacteria	P	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_3012168_1	1033744.CAEL01000019_gene176	5.296e-35	136.0	COG2049@1|root,COG2049@2|Bacteria,1TTBZ@1239|Firmicutes,24A35@186801|Clostridia	186801|Clostridia	E	Allophanate hydrolase subunit 1	kipI	-	-	ko:K06351	-	-	-	-	ko00000	-	-	-	CT_C_D
HKD1_k127_3022570_0	1195236.CTER_0261	5.629e-214	675.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,3WH2F@541000|Ruminococcaceae	186801|Clostridia	G	ABC-type sugar transport system, ATPase component	-	-	3.6.3.17	ko:K10441	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	ABC_tran
HKD1_k127_3022570_1	1195236.CTER_0262	5.28e-85	290.0	COG1879@1|root,COG1879@2|Bacteria,1UE0M@1239|Firmicutes,24C7Y@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system, periplasmic	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD1_k127_3032494_1	1121289.JHVL01000015_gene2698	1.793e-20	96.0	COG3629@1|root,COG3629@2|Bacteria,1UWHI@1239|Firmicutes,24AC8@186801|Clostridia,36I07@31979|Clostridiaceae	186801|Clostridia	K	chemotaxis response regulator protein-glutamate methylesterase 1	-	-	-	-	-	-	-	-	-	-	-	-	BTAD,GGDEF,Trans_reg_C
HKD1_k127_3032494_0	768706.Desor_5448	9.068e-49	184.0	COG2199@1|root,COG2206@1|root,COG2199@2|Bacteria,COG2206@2|Bacteria,1V6WM@1239|Firmicutes,25E5R@186801|Clostridia,2603J@186807|Peptococcaceae	186801|Clostridia	T	diguanylate cyclase (GGDEF) domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS_9
HKD1_k127_3053900_0	1286171.EAL2_808p04270	2.15e-85	290.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,25VZ9@186806|Eubacteriaceae	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_3053900_1	1286171.EAL2_808p04270	1.864e-08	59.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,25VZ9@186806|Eubacteriaceae	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_3059591_1	573061.Clocel_0856	4.263e-138	443.0	COG2271@1|root,COG2271@2|Bacteria,1TS8G@1239|Firmicutes,24F9J@186801|Clostridia,36GAM@31979|Clostridiaceae	186801|Clostridia	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08170	-	M00702	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3.23,2.A.1.3.59	-	-	MFS_1
HKD1_k127_3059591_0	536227.CcarbDRAFT_2051	1.747e-167	529.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_306157_0	293826.Amet_1335	5.744e-183	586.0	COG2509@1|root,COG2509@2|Bacteria,1TPBW@1239|Firmicutes,247TR@186801|Clostridia,36DE1@31979|Clostridiaceae	186801|Clostridia	S	Oxidoreductase	-	-	-	ko:K07137	-	-	-	-	ko00000	-	-	-	HI0933_like,NAD_binding_8,Pyr_redox_2
HKD1_k127_306157_1	865861.AZSU01000010_gene751	4.065e-37	143.0	COG2081@1|root,COG2081@2|Bacteria,1TR7U@1239|Firmicutes,2497W@186801|Clostridia,36EA5@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HKD1_k127_307088_0	1151292.QEW_2235	3.522e-129	420.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,25QJM@186804|Peptostreptococcaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_3079524_2	1487921.DP68_18190	2.313e-12	67.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	macB	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3079524_0	1232449.BAHV02000001_gene361	2.277e-112	375.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,2688J@186813|unclassified Clostridiales	186801|Clostridia	V	Psort location CytoplasmicMembrane, score 10.00	macB1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_3079524_1	411467.BACCAP_01674	2.001e-35	148.0	COG0737@1|root,COG0737@2|Bacteria,1UK63@1239|Firmicutes,25FMA@186801|Clostridia,26CII@186813|unclassified Clostridiales	186801|Clostridia	F	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_30942_4	1121289.JHVL01000020_gene828	9.64e-87	293.0	COG0629@1|root,COG0629@2|Bacteria,1TRWZ@1239|Firmicutes,248UD@186801|Clostridia,36DDV@31979|Clostridiaceae	186801|Clostridia	L	PFAM single-strand binding protein	ssb1	-	-	-	-	-	-	-	-	-	-	-	SSB
HKD1_k127_30942_1	1304284.L21TH_0551	5.751e-160	511.0	COG0012@1|root,COG0012@2|Bacteria,1TPRK@1239|Firmicutes,2482Z@186801|Clostridia,36E7J@31979|Clostridiaceae	186801|Clostridia	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD1_k127_30942_5	411490.ANACAC_03681	3.536e-54	193.0	COG0355@1|root,COG0355@2|Bacteria,1VA89@1239|Firmicutes,24ND7@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE,ATP-synt_DE_N
HKD1_k127_30942_0	411490.ANACAC_03682	1.135e-262	813.0	COG0055@1|root,COG0055@2|Bacteria,1TPGF@1239|Firmicutes,2489W@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_30942_2	411490.ANACAC_03683	2.102e-118	387.0	COG0224@1|root,COG0224@2|Bacteria,1TPBX@1239|Firmicutes,2486Q@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD1_k127_30942_3	411490.ANACAC_03684	9.939e-97	319.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
HKD1_k127_3121279_0	1211817.CCAT010000062_gene4057	1.286e-27	116.0	COG4187@1|root,COG4187@2|Bacteria,1TQQ7@1239|Firmicutes,249CV@186801|Clostridia,36EX1@31979|Clostridiaceae	186801|Clostridia	E	Peptidase family M20/M25/M40	rocB	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M20
HKD1_k127_3121279_1	402880.MmarC5_0900	1.041e-07	59.0	COG2607@1|root,arCOG05101@2157|Archaea,2XWSM@28890|Euryarchaeota	28890|Euryarchaeota	S	SMART AAA ATPase	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD1_k127_3123668_1	1354300.AUQY01000002_gene846	2.101e-118	383.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,22FY4@1570339|Peptoniphilaceae	186801|Clostridia	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_3123668_2	350688.Clos_1721	5.592e-23	102.0	COG1862@1|root,COG1862@2|Bacteria,1VEMC@1239|Firmicutes,24MMT@186801|Clostridia,36MPE@31979|Clostridiaceae	186801|Clostridia	U	Preprotein translocase, YajC subunit	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD1_k127_3123668_0	500632.CLONEX_00439	2.579e-304	956.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_3129573_0	1321784.HMPREF1987_00474	6.335e-101	333.0	COG0813@1|root,COG0813@2|Bacteria,1TQPG@1239|Firmicutes,248G6@186801|Clostridia,25SQ2@186804|Peptostreptococcaceae	186801|Clostridia	F	Phosphorylase superfamily	deoD	-	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_3129573_1	1487921.DP68_05545	8.089e-24	104.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,25DA4@186801|Clostridia,36VE3@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_3136010_0	469617.FUAG_02063	5.132e-68	232.0	COG3246@1|root,COG3246@2|Bacteria,378JF@32066|Fusobacteria	32066|Fusobacteria	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
HKD1_k127_3136010_1	1280692.AUJL01000024_gene3408	4.698e-57	202.0	COG2030@1|root,COG2030@2|Bacteria,1V6MY@1239|Firmicutes,24NB6@186801|Clostridia,36M8N@31979|Clostridiaceae	186801|Clostridia	I	PFAM MaoC domain protein dehydratase	-	-	4.2.1.55	ko:K17865	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R03027	RC00831	ko00000,ko00001,ko00002,ko01000	-	-	-	MaoC_dehydratas
HKD1_k127_3136010_2	994573.T472_0216955	5.436e-42	160.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_3140024_0	1321778.HMPREF1982_04312	0.0	1404.0	COG1012@1|root,COG1454@1|root,COG1012@2|Bacteria,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,2686V@186813|unclassified Clostridiales	186801|Clostridia	C	belongs to the iron- containing alcohol dehydrogenase family	adhE1	-	1.1.1.1,1.2.1.10	ko:K04072	ko00010,ko00071,ko00350,ko00620,ko00625,ko00626,ko00650,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00620,map00625,map00626,map00650,map01100,map01110,map01120,map01130,map01220	-	R00228,R00623,R00754,R01172,R04880,R05233,R05234,R06917,R06927	RC00004,RC00050,RC00088,RC00099,RC00116,RC00184,RC00649,RC01195	ko00000,ko00001,ko01000	-	-	-	Aldedh,Fe-ADH
HKD1_k127_3145486_2	386415.NT01CX_1212	1.704e-40	152.0	COG3039@1|root,COG3039@2|Bacteria,1TPFS@1239|Firmicutes,24Z0V@186801|Clostridia,36R6T@31979|Clostridiaceae	186801|Clostridia	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF772
HKD1_k127_3145486_0	1121289.JHVL01000002_gene2354	1.686e-155	499.0	COG0484@1|root,COG0484@2|Bacteria,1TP00@1239|Firmicutes,248EM@186801|Clostridia,36E5A@31979|Clostridiaceae	186801|Clostridia	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686,ko:K05516	-	-	-	-	ko00000,ko03029,ko03036,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD1_k127_3145486_1	1286171.EAL2_c14420	7.003e-135	439.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,25VH9@186806|Eubacteriaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_3146778_1	397290.C810_02212	1.893e-06	53.0	2DP3R@1|root,330E2@2|Bacteria,1VEPT@1239|Firmicutes,24QJB@186801|Clostridia,27P1U@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
HKD1_k127_3146778_0	1286171.EAL2_c15700	4.961e-44	173.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia,25WEQ@186806|Eubacteriaceae	186801|Clostridia	L	Beta propeller domain	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
HKD1_k127_3162412_2	509191.AEDB02000099_gene4004	1.588e-13	76.0	COG1361@1|root,COG3210@1|root,COG1361@2|Bacteria,COG3210@2|Bacteria,1UITS@1239|Firmicutes,25ERA@186801|Clostridia,3WSI8@541000|Ruminococcaceae	186801|Clostridia	MU	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_3162412_1	1121334.KB911069_gene1615	1.451e-47	175.0	COG1871@1|root,COG1871@2|Bacteria,1V70X@1239|Firmicutes,24HH7@186801|Clostridia,3WKBQ@541000|Ruminococcaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HKD1_k127_3162412_0	1105031.HMPREF1141_2829	4.767e-56	202.0	COG1776@1|root,COG1776@2|Bacteria,1UNKB@1239|Firmicutes,247MX@186801|Clostridia,36H30@31979|Clostridiaceae	186801|Clostridia	NT	chemotaxis protein	cheC	-	-	ko:K03410	ko02030,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheC
HKD1_k127_3172646_1	1120998.AUFC01000008_gene1107	3.4e-17	82.0	COG0642@1|root,COG2205@2|Bacteria,1TSCS@1239|Firmicutes,25ECA@186801|Clostridia	186801|Clostridia	T	Histidine kinase	cssS	-	2.7.13.3	ko:K07650	ko02020,map02020	M00448	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_3172646_0	1120998.AUFC01000021_gene981	4.036e-84	291.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia	186801|Clostridia	J	tRNA nucleotidyltransferase poly(A) polymerase	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD1_k127_3182172_0	913865.DOT_4366	3.615e-183	580.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_3182172_1	913865.DOT_4365	1.54e-167	533.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247T8@186801|Clostridia	186801|Clostridia	V	Abc transporter	yfiB	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_31839_0	386415.NT01CX_0335	2.39e-155	496.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,36DHG@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
HKD1_k127_3204511_0	1304284.L21TH_0782	1.143e-247	777.0	COG0480@1|root,COG0480@2|Bacteria,1TPWN@1239|Firmicutes,247N4@186801|Clostridia,36DFR@31979|Clostridiaceae	186801|Clostridia	J	elongation factor G	fusA2	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_3204511_1	1196322.A370_02881	5.932e-28	118.0	COG4399@1|root,COG4399@2|Bacteria,1V3CY@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD1_k127_3229911_0	1304284.L21TH_0074	7.947e-73	257.0	COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia,36F7E@31979|Clostridiaceae	186801|Clostridia	L	DNA replication protein DnaD	dnaD	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
HKD1_k127_3229911_1	1301100.HG529418_gene3016	3.555e-30	124.0	COG1484@1|root,COG1484@2|Bacteria,1TPKM@1239|Firmicutes,2483D@186801|Clostridia,36DQQ@31979|Clostridiaceae	186801|Clostridia	L	DNA replication protein	dnaC	-	-	ko:K02315	-	-	-	-	ko00000,ko03032	-	-	-	IstB_IS21
HKD1_k127_3229966_0	1304284.L21TH_2690	8.682e-46	176.0	COG1466@1|root,COG1466@2|Bacteria,1TRM0@1239|Firmicutes,24ASN@186801|Clostridia,36FMH@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase III delta subunit	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD1_k127_32531_1	536227.CcarbDRAFT_2016	3.488e-109	355.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_32531_3	332101.JIBU02000012_gene929	4.675e-77	269.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia,36GYG@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_32531_0	1232428.CAVO010000136_gene93	2.636e-118	386.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,4H2Y2@909932|Negativicutes	909932|Negativicutes	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_32531_2	1449338.JQLU01000005_gene2903	2.282e-83	283.0	COG0710@1|root,COG0710@2|Bacteria,1TSPN@1239|Firmicutes,4HDMG@91061|Bacilli	91061|Bacilli	E	Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3- dehydroshikimate	aroD	GO:0003674,GO:0003824,GO:0003855,GO:0006082,GO:0006725,GO:0008150,GO:0008152,GO:0009058,GO:0009712,GO:0009713,GO:0009987,GO:0016053,GO:0016829,GO:0016835,GO:0016836,GO:0017144,GO:0018958,GO:0019438,GO:0019752,GO:0032787,GO:0042537,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046189,GO:0046278,GO:0046279,GO:0046394,GO:0071704,GO:0072330,GO:1901360,GO:1901362,GO:1901576,GO:1901615,GO:1901617	4.2.1.10	ko:K03785	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_I
HKD1_k127_326843_1	1304284.L21TH_1026	9.2e-50	179.0	COG0292@1|root,COG0292@2|Bacteria,1V6DB@1239|Firmicutes,24JBJ@186801|Clostridia,36ITT@31979|Clostridiaceae	186801|Clostridia	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD1_k127_326843_2	338963.Pcar_1420	1.811e-13	72.0	COG0291@1|root,COG0291@2|Bacteria,1QDQ4@1224|Proteobacteria,42VSG@68525|delta/epsilon subdivisions,2WREY@28221|Deltaproteobacteria,43SRN@69541|Desulfuromonadales	28221|Deltaproteobacteria	J	Ribosomal protein L35	rpmI	GO:0003674,GO:0003735,GO:0005198,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0015934,GO:0022625,GO:0022626,GO:0032991,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:1990904	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD1_k127_326843_0	1304284.L21TH_1024	5.752e-73	248.0	COG0290@1|root,COG0290@2|Bacteria,1V1RC@1239|Firmicutes,24FUS@186801|Clostridia,36I2Z@31979|Clostridiaceae	186801|Clostridia	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD1_k127_3284922_2	1121289.JHVL01000003_gene2278	1.155e-42	159.0	COG1302@1|root,COG1302@2|Bacteria,1V731@1239|Firmicutes,24JIA@186801|Clostridia,36JGK@31979|Clostridiaceae	186801|Clostridia	S	Asp23 family, cell envelope-related function	-	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD1_k127_3284922_0	1304284.L21TH_1431	1.496e-184	592.0	COG1461@1|root,COG1461@2|Bacteria,1TQMX@1239|Firmicutes,247XI@186801|Clostridia,36E63@31979|Clostridiaceae	186801|Clostridia	S	DAK2 domain fusion protein YloV	yloV	-	-	ko:K07030	-	-	-	-	ko00000	-	-	-	Dak1_2,Dak2
HKD1_k127_3284922_1	1304284.L21TH_1432	2.182e-145	475.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,36EV7@31979|Clostridiaceae	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_3298206_1	1449050.JNLE01000003_gene2285	6.203e-82	273.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36DRC@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidase domain protein	glcD1	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_3298206_0	994573.T472_0204260	2.484e-150	479.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,36DMW@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2088)	-	-	5.1.2.1	ko:K22373	ko00620,map00620	-	R01450	RC00519	ko00000,ko00001,ko01000	-	-	-	DUF2088
HKD1_k127_3311354_0	350688.Clos_0465	2.535e-217	680.0	COG0442@1|root,COG0442@2|Bacteria,1TRBV@1239|Firmicutes,249PY@186801|Clostridia,36DVT@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS	proS	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,ProRS-C_1,tRNA-synt_2b,tRNA_edit
HKD1_k127_3325889_2	86416.Clopa_1363	5.378e-116	377.0	COG0842@1|root,COG0842@2|Bacteria,1TQ9K@1239|Firmicutes,24C8W@186801|Clostridia,36ID2@31979|Clostridiaceae	186801|Clostridia	V	ABC-2 type transporter	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD1_k127_3325889_1	86416.Clopa_1362	3.294e-146	466.0	COG1131@1|root,COG1131@2|Bacteria,1TQN1@1239|Firmicutes,25AZK@186801|Clostridia,36W6Y@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3325889_0	1105031.HMPREF1141_2016	2.238e-147	472.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia,36E13@31979|Clostridiaceae	186801|Clostridia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	hprA	-	1.1.1.29	ko:K00018	ko00260,ko00630,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,map00260,map00630,map00680,map01100,map01110,map01120,map01130,map01200	M00346	R00717,R01388	RC00031,RC00042	ko00000,ko00001,ko00002,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3325889_3	994573.T472_0204265	1.033e-14	74.0	COG1929@1|root,COG1929@2|Bacteria,1TPSI@1239|Firmicutes,249SH@186801|Clostridia,36E78@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the glycerate kinase type-1 family	glxK	-	2.7.1.165	ko:K00865	ko00260,ko00561,ko00630,ko01100,ko01120,ko01130,map00260,map00561,map00630,map01100,map01120,map01130	-	R08572	RC00002,RC00428	ko00000,ko00001,ko01000	-	-	-	Gly_kinase
HKD1_k127_3326254_0	357809.Cphy_2422	1.844e-73	254.0	COG0566@1|root,COG0566@2|Bacteria,1TS18@1239|Firmicutes,24KJT@186801|Clostridia	186801|Clostridia	J	SpoU rRNA Methylase family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_3326254_1	357809.Cphy_2097	3.725e-08	57.0	2DS1B@1|root,33E38@2|Bacteria,1VM58@1239|Firmicutes,24V1J@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3368572_1	469617.FUAG_01160	2.545e-79	268.0	COG1250@1|root,COG1250@2|Bacteria,3797U@32066|Fusobacteria	32066|Fusobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_3368572_0	350688.Clos_2443	3.124e-137	438.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia,36DPI@31979|Clostridiaceae	186801|Clostridia	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
HKD1_k127_3368936_2	748727.CLJU_c04800	2.243e-12	70.0	2CGVU@1|root,32S4Q@2|Bacteria,1V9YX@1239|Firmicutes,24NX8@186801|Clostridia,36KG8@31979|Clostridiaceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3368936_0	688269.Theth_0199	2.747e-48	177.0	COG0440@1|root,COG0440@2|Bacteria,2GE61@200918|Thermotogae	200918|Thermotogae	E	TIGRFAM acetolactate synthase, small subunit	-	-	2.2.1.6	ko:K01653	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT_5,ALS_ss_C
HKD1_k127_3368936_1	203119.Cthe_2516	3.697e-29	120.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,3WHFZ@541000|Ruminococcaceae	186801|Clostridia	H	acetolactate synthase large subunit	ilvI	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_3381806_0	272563.CD630_05740	2.04e-270	838.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,25QSG@186804|Peptostreptococcaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD1_k127_3391342_2	536227.CcarbDRAFT_1270	4.587e-26	112.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36HY5@31979|Clostridiaceae	186801|Clostridia	J	GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_3391342_0	1121334.KB911066_gene783	1.123e-162	518.0	COG0407@1|root,COG0407@2|Bacteria,1V0ET@1239|Firmicutes,24CXU@186801|Clostridia,3WQHX@541000|Ruminococcaceae	186801|Clostridia	H	Uroporphyrinogen decarboxylase (URO-D)	-	-	-	-	-	-	-	-	-	-	-	-	URO-D
HKD1_k127_3391342_1	1105031.HMPREF1141_1833	1.042e-62	223.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,36DWI@31979|Clostridiaceae	186801|Clostridia	P	amino acid ABC transporter	-	-	-	ko:K02029,ko:K16962	ko02010,map02010	M00236,M00586	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1
HKD1_k127_3391342_3	1121334.KB911066_gene785	1.663e-21	96.0	COG0765@1|root,COG0765@2|Bacteria,1V8JX@1239|Firmicutes,25C32@186801|Clostridia	186801|Clostridia	E	Binding-protein-dependent transport system inner membrane component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_339711_1	386415.NT01CX_0640	2.675e-94	314.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E4P@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_339711_0	1304284.L21TH_0869	2.579e-102	338.0	COG4123@1|root,COG4123@2|Bacteria,1TQ25@1239|Firmicutes,249UH@186801|Clostridia,36F66@31979|Clostridiaceae	186801|Clostridia	S	Methyltransferase	yfiC	-	2.1.1.223	ko:K15460	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	MTS,Methyltransf_31
HKD1_k127_3397798_0	1304284.L21TH_0369	4.938e-151	484.0	COG0312@1|root,COG0312@2|Bacteria,1TSQC@1239|Firmicutes,248MD@186801|Clostridia,36F5C@31979|Clostridiaceae	186801|Clostridia	S	modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD1_k127_3398182_1	903814.ELI_0783	5.232e-54	196.0	COG2087@1|root,COG2087@2|Bacteria,1V6F8@1239|Firmicutes,24JF6@186801|Clostridia,25WWS@186806|Eubacteriaceae	186801|Clostridia	H	Adenosylcobinamide kinase adenosylcobinamide-phosphate guanylyltransferase	cobU	-	2.7.1.156,2.7.7.62	ko:K02231	ko00860,ko01100,map00860,map01100	M00122	R05221,R05222,R06558	RC00002,RC00428	ko00000,ko00001,ko00002,ko01000	-	-	-	CobU
HKD1_k127_3398182_2	1304284.L21TH_1561	1.211e-45	174.0	COG0368@1|root,COG0368@2|Bacteria,1V1QB@1239|Firmicutes,24I0D@186801|Clostridia,36H10@31979|Clostridiaceae	186801|Clostridia	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	-	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD1_k127_3398182_3	1304284.L21TH_1562	2.672e-26	116.0	COG0406@1|root,COG0406@2|Bacteria,1VEMM@1239|Firmicutes,24GJW@186801|Clostridia,36KFN@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	cobC	-	3.1.3.73	ko:K02226	ko00860,ko01100,map00860,map01100	M00122	R04594,R11173	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	His_Phos_1
HKD1_k127_3398182_0	941824.TCEL_01823	9.61e-121	392.0	COG0282@1|root,COG0282@2|Bacteria,1TQ22@1239|Firmicutes,248ZM@186801|Clostridia,36EE0@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction	ackA	GO:0006082,GO:0006083,GO:0008150,GO:0008152,GO:0009058,GO:0009987,GO:0016053,GO:0016999,GO:0017000,GO:0017144,GO:0019413,GO:0019752,GO:0032787,GO:0043436,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:0072330,GO:1901576	2.7.2.1	ko:K00925	ko00430,ko00620,ko00640,ko00680,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00680,map00720,map01100,map01120,map01200	M00357,M00579	R00315,R01353	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	Acetate_kinase
HKD1_k127_3412371_2	1120998.AUFC01000009_gene2145	1.007e-26	112.0	COG1470@1|root,COG3209@1|root,COG4733@1|root,COG5263@1|root,COG1470@2|Bacteria,COG3209@2|Bacteria,COG4733@2|Bacteria,COG5263@2|Bacteria,1UYJ9@1239|Firmicutes,248QE@186801|Clostridia,3WDEC@538999|Clostridiales incertae sedis	186801|Clostridia	M	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_3_5,CW_binding_1,SLH
HKD1_k127_3412371_0	350688.Clos_0224	9.036e-31	125.0	2B94X@1|root,322FX@2|Bacteria,1V7VA@1239|Firmicutes,24K7Q@186801|Clostridia,36KSU@31979|Clostridiaceae	186801|Clostridia	S	zinc-ribbon family	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_15
HKD1_k127_3412371_1	1202532.FF52_13696	5.284e-28	119.0	COG2315@1|root,COG2315@2|Bacteria,4NS6J@976|Bacteroidetes,1I2YP@117743|Flavobacteriia,2NW86@237|Flavobacterium	976|Bacteroidetes	S	MmcQ-like protein	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD1_k127_3416345_0	536227.CcarbDRAFT_2010	8.251e-261	810.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_3416345_1	332101.JIBU02000012_gene937	7.444e-140	449.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_3427662_1	1304284.L21TH_1370	3.924e-107	357.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,36DW8@31979|Clostridiaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD1_k127_3427662_2	1347392.CCEZ01000022_gene830	2.029e-37	148.0	COG0576@1|root,COG0576@2|Bacteria,1V6G2@1239|Firmicutes,24MQK@186801|Clostridia,36IQB@31979|Clostridiaceae	186801|Clostridia	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD1_k127_3427662_0	1304284.L21TH_1368	5.59e-215	673.0	COG0443@1|root,COG0443@2|Bacteria,1TP1J@1239|Firmicutes,248QV@186801|Clostridia,36DJ7@31979|Clostridiaceae	186801|Clostridia	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD1_k127_3429831_0	536227.CcarbDRAFT_3122	4.51e-100	332.0	COG3608@1|root,COG3608@2|Bacteria,1TRKT@1239|Firmicutes,2492W@186801|Clostridia,36E0K@31979|Clostridiaceae	186801|Clostridia	S	Selenium-dependent molybdenum hydroxylase system protein, YqeB family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	NTP_transf_3
HKD1_k127_3429831_1	1262449.CP6013_2860	3.047e-49	182.0	COG2068@1|root,COG2068@2|Bacteria,1VA0F@1239|Firmicutes,24KIZ@186801|Clostridia,36I3A@31979|Clostridiaceae	186801|Clostridia	S	MobA-like NTP transferase domain	ygfJ	-	2.7.7.76	ko:K07141	ko00790,map00790	-	R11582	-	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3
HKD1_k127_3429831_2	1410653.JHVC01000001_gene1864	3.702e-44	169.0	COG1192@1|root,COG1192@2|Bacteria,1UI78@1239|Firmicutes,25ECF@186801|Clostridia,36I2D@31979|Clostridiaceae	186801|Clostridia	D	Involved in chromosome partitioning	yqeC	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3439933_1	457405.FSDG_01299	1.602e-38	149.0	COG1473@1|root,COG1473@2|Bacteria,378IU@32066|Fusobacteria	32066|Fusobacteria	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3439933_0	580340.Tlie_0008	9.425e-126	414.0	COG1288@1|root,COG1288@2|Bacteria,3T9Y3@508458|Synergistetes	508458|Synergistetes	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_3449529_0	1304284.L21TH_1637	4.906e-134	440.0	COG0773@1|root,COG0773@2|Bacteria,1TQ5H@1239|Firmicutes,2484K@186801|Clostridia,36DVH@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3449529_2	720554.Clocl_2061	1.457e-88	302.0	COG0142@1|root,COG0142@2|Bacteria,1TPQY@1239|Firmicutes,248DE@186801|Clostridia,3WINP@541000|Ruminococcaceae	186801|Clostridia	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10,2.5.1.29	ko:K13789	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364,M00366	R01658,R02003,R02061	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	iHN637.CLJU_RS05465	polyprenyl_synt
HKD1_k127_3449529_1	931276.Cspa_c16100	2.257e-112	371.0	COG0646@1|root,COG1410@1|root,COG0646@2|Bacteria,COG1410@2|Bacteria,1TPYV@1239|Firmicutes,248JB@186801|Clostridia,36DUH@31979|Clostridiaceae	186801|Clostridia	E	Methionine synthase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Pterin_bind,S-methyl_trans
HKD1_k127_3456010_0	552398.HMPREF0866_03037	3.542e-149	475.0	COG1834@1|root,COG1834@2|Bacteria,1VDT8@1239|Firmicutes,25EE3@186801|Clostridia,3WR2S@541000|Ruminococcaceae	186801|Clostridia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD1_k127_3456010_1	552398.HMPREF0866_03038	1.339e-137	447.0	COG4187@1|root,COG4187@2|Bacteria,1TQQ7@1239|Firmicutes,249CV@186801|Clostridia	186801|Clostridia	E	peptidase, M20	rocB	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M20
HKD1_k127_3456333_1	1139219.I569_02311	9.337e-29	116.0	COG2171@1|root,COG2171@2|Bacteria,1TQUJ@1239|Firmicutes,4H9KY@91061|Bacilli,4B0XP@81852|Enterococcaceae	91061|Bacilli	E	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate	dapH	-	2.3.1.117,2.3.1.89	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	M00016,M00525	R04364,R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	iYO844.BSU14180	DapH_N,Hexapep
HKD1_k127_3456333_0	1408439.JHXW01000011_gene238	2.359e-118	387.0	COG0527@1|root,COG0527@2|Bacteria,37857@32066|Fusobacteria	32066|Fusobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_346633_2	1304284.L21TH_0804	1.008e-49	178.0	COG0634@1|root,COG0634@2|Bacteria,1V1C9@1239|Firmicutes,24FR4@186801|Clostridia,36HYM@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the purine pyrimidine phosphoribosyltransferase family	hpt	-	2.4.2.8	ko:K00760	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	-	R00190,R01132,R01229,R02142,R08237,R08238,R08245	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD1_k127_346633_0	1304284.L21TH_0803	2.932e-272	849.0	COG0465@1|root,COG0465@2|Bacteria,1TPTV@1239|Firmicutes,247WQ@186801|Clostridia,36DIC@31979|Clostridiaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_346633_3	1449050.JNLE01000003_gene2559	1.585e-47	173.0	2DMWG@1|root,32U3S@2|Bacteria,1VA7F@1239|Firmicutes,24MP5@186801|Clostridia,36KKW@31979|Clostridiaceae	186801|Clostridia	S	YmaF family	-	-	-	-	-	-	-	-	-	-	-	-	YmaF
HKD1_k127_346633_1	1304284.L21TH_0800	1.309e-84	282.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD1_k127_3478759_0	1511.CLOST_0902	9.526e-121	403.0	COG4124@1|root,COG4124@2|Bacteria,1U8S3@1239|Firmicutes,24C93@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolase family 26	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HKD1_k127_3478759_1	293826.Amet_3793	1.104e-43	169.0	COG1943@1|root,COG1943@2|Bacteria,1V553@1239|Firmicutes,2495R@186801|Clostridia,36F6G@31979|Clostridiaceae	186801|Clostridia	L	Transposase IS200 like	-	-	-	-	-	-	-	-	-	-	-	-	Y1_Tnp
HKD1_k127_348829_0	1304284.L21TH_1032	5.387e-199	632.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,36DSY@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
HKD1_k127_348829_2	1121342.AUCO01000008_gene10	8.268e-46	170.0	COG0072@1|root,COG0072@2|Bacteria,1TP98@1239|Firmicutes,248BJ@186801|Clostridia,36DSY@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA-synt_2d,tRNA_bind
HKD1_k127_348829_1	1347392.CCEZ01000043_gene189	1.307e-101	336.0	COG0682@1|root,COG0682@2|Bacteria,1TPAK@1239|Firmicutes,24APG@186801|Clostridia,36F3Y@31979|Clostridiaceae	186801|Clostridia	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD1_k127_3501151_2	742723.HMPREF9477_01173	3.219e-69	246.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,27KY2@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD1_k127_3501151_0	1304284.L21TH_2102	2.62e-111	362.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,36W97@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_3501151_1	1211817.CCAT010000084_gene1840	4.45e-102	336.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,36DTQ@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_350482_1	1262449.CP6013_2734	4.702e-60	209.0	COG0648@1|root,COG0648@2|Bacteria,1TP1D@1239|Firmicutes,2499E@186801|Clostridia,36F6F@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin	nfo	-	3.1.21.2	ko:K01151	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AP_endonuc_2
HKD1_k127_350482_0	536233.CLO_1889	2.082e-165	525.0	COG1533@1|root,COG1533@2|Bacteria,1TPA3@1239|Firmicutes,249NM@186801|Clostridia,36FQ3@31979|Clostridiaceae	186801|Clostridia	L	Spore photoproduct lyase	splB	GO:0003674,GO:0003824,GO:0003913,GO:0005488,GO:0016829,GO:0016830,GO:0043167,GO:0043169,GO:0046872,GO:0048037,GO:0051536,GO:0051540,GO:0070283,GO:0140097	4.1.99.14	ko:K03716	-	-	-	-	ko00000,ko01000	-	-	-	Radical_SAM
HKD1_k127_3516126_0	1511.CLOST_1201	1.597e-166	527.0	COG3842@1|root,COG3842@2|Bacteria,1TP2M@1239|Firmicutes,247JR@186801|Clostridia,25QEJ@186804|Peptostreptococcaceae	186801|Clostridia	P	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system	potA	-	3.6.3.31	ko:K11072	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.11.1	-	-	ABC_tran,TOBE_2
HKD1_k127_3516126_1	1511.CLOST_1202	1.565e-153	489.0	COG1176@1|root,COG1176@2|Bacteria,1TQ7Z@1239|Firmicutes,247Y8@186801|Clostridia,25QQU@186804|Peptostreptococcaceae	186801|Clostridia	P	ABC transporter permease	potB	-	-	ko:K11071	ko02010,map02010	M00299	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.11.1	-	-	BPD_transp_1
HKD1_k127_3516767_0	1304284.L21TH_1547	1.063e-146	471.0	COG1186@1|root,COG1186@2|Bacteria,1TPSB@1239|Firmicutes,247KU@186801|Clostridia,36DUM@31979|Clostridiaceae	186801|Clostridia	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD1_k127_3516767_1	1304284.L21TH_1549	3.937e-84	284.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,36DQ1@31979|Clostridiaceae	186801|Clostridia	K	domain protein	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD1_k127_3518058_0	1345695.CLSA_c06360	2.596e-21	106.0	COG4399@1|root,COG4399@2|Bacteria,1V3CY@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD1_k127_351954_1	1347392.CCEZ01000043_gene102	4.78e-44	166.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
HKD1_k127_351954_0	742740.HMPREF9474_03584	1.215e-109	362.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,21Z53@1506553|Lachnoclostridium	186801|Clostridia	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_8,Sigma54_activat
HKD1_k127_3531608_1	1304284.L21TH_1092	1.28e-91	305.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,36DGA@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_3531608_0	1304284.L21TH_1091	1.288e-169	540.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,36DIR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
HKD1_k127_35444_0	650150.ERH_1479	1.086e-118	391.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,3VQ14@526524|Erysipelotrichia	526524|Erysipelotrichia	S	ATPases associated with a variety of cellular activities	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_3551762_2	1449050.JNLE01000003_gene1395	3.062e-49	177.0	COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,24A2V@186801|Clostridia,36FHT@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD1_k127_3551762_0	1449050.JNLE01000003_gene1396	4.501e-110	360.0	COG1116@1|root,COG1116@2|Bacteria,1TSW5@1239|Firmicutes,25AZG@186801|Clostridia,36GVM@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system ATPase component	-	-	-	ko:K02049	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	ABC_tran
HKD1_k127_3551762_1	1280692.AUJL01000021_gene623	1.034e-71	243.0	COG2368@1|root,COG2368@2|Bacteria,1TQ70@1239|Firmicutes,248RP@186801|Clostridia,36DTV@31979|Clostridiaceae	186801|Clostridia	Q	4-hydroxyphenylacetate 3-hydroxylase C terminal	abfD	-	1.14.14.9,4.2.1.120,5.3.3.3	ko:K00483,ko:K14534	ko00350,ko00650,ko00720,ko01100,ko01120,ko01200,ko01220,map00350,map00650,map00720,map01100,map01120,map01200,map01220	M00374,M00375	R02698,R03031,R03299,R10782	RC00046,RC01857,RC03277	ko00000,ko00001,ko00002,ko01000	-	-	-	HpaB,HpaB_N
HKD1_k127_355636_3	350688.Clos_1250	4.979e-21	95.0	COG1470@1|root,COG1470@2|Bacteria,1TRGE@1239|Firmicutes,24EHG@186801|Clostridia,36FWD@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF3048) C-terminal domain	yerB	-	-	-	-	-	-	-	-	-	-	-	DUF3048,DUF3048_C
HKD1_k127_355636_1	1128398.Curi_c18110	4.727e-49	177.0	COG0295@1|root,COG0295@2|Bacteria,1V6IP@1239|Firmicutes,24JEM@186801|Clostridia,268ZJ@186813|unclassified Clostridiales	186801|Clostridia	F	This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis	cdd	-	3.5.4.5	ko:K01489	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000	-	-	-	dCMP_cyt_deam_1
HKD1_k127_355636_0	1391646.AVSU01000026_gene2364	2.56e-112	370.0	COG1159@1|root,COG1159@2|Bacteria,1TP3R@1239|Firmicutes,24876@186801|Clostridia,25QEP@186804|Peptostreptococcaceae	186801|Clostridia	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD1_k127_355636_2	1121289.JHVL01000002_gene2334	1.012e-36	146.0	COG1381@1|root,COG1381@2|Bacteria,1UZ19@1239|Firmicutes,249TI@186801|Clostridia,36FFV@31979|Clostridiaceae	186801|Clostridia	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD1_k127_3567512_0	318464.IO99_18375	1.614e-113	369.0	COG0701@1|root,COG0701@2|Bacteria,1TQC7@1239|Firmicutes,24A02@186801|Clostridia,36EPA@31979|Clostridiaceae	186801|Clostridia	S	permease	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_1
HKD1_k127_3567512_1	509191.AEDB02000104_gene3832	1.192e-32	128.0	COG0526@1|root,COG0526@2|Bacteria,1VEYC@1239|Firmicutes,24QMF@186801|Clostridia,3WKWC@541000|Ruminococcaceae	186801|Clostridia	CO	redox-active disulfide protein 2	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_3
HKD1_k127_3567512_2	610130.Closa_2685	4.147e-31	124.0	COG0640@1|root,COG0640@2|Bacteria,1VEER@1239|Firmicutes,24QZK@186801|Clostridia,221ET@1506553|Lachnoclostridium	186801|Clostridia	K	PFAM regulatory protein ArsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_357894_1	195103.CPF_0552	1.001e-16	82.0	2E5UQ@1|root,330IY@2|Bacteria,1VI50@1239|Firmicutes,24QVH@186801|Clostridia,36N7F@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_357894_0	272562.CA_C2804	9.188e-121	392.0	COG0491@1|root,COG0491@2|Bacteria,1TQGU@1239|Firmicutes,24CEH@186801|Clostridia,36H3T@31979|Clostridiaceae	186801|Clostridia	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_358562_0	632245.CLP_1572	2.105e-108	360.0	COG4632@1|root,COG4632@2|Bacteria,1TR6Z@1239|Firmicutes,25B3H@186801|Clostridia,36WHR@31979|Clostridiaceae	186801|Clostridia	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD1_k127_358562_1	1131462.DCF50_p2769	1.145e-15	78.0	COG1216@1|root,COG2246@1|root,COG1216@2|Bacteria,COG2246@2|Bacteria,1UIHV@1239|Firmicutes,25FGV@186801|Clostridia	186801|Clostridia	M	Glycosyltransferase, group 2 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,GtrA
HKD1_k127_3598132_1	1321778.HMPREF1982_02993	1.425e-38	146.0	COG2846@1|root,COG2846@2|Bacteria,1UYJV@1239|Firmicutes,24GZI@186801|Clostridia,26BY9@186813|unclassified Clostridiales	186801|Clostridia	D	Domain of Unknown function (DUF542)	ric	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	Hemerythrin,ScdA_N
HKD1_k127_3598132_0	86416.Clopa_2075	4.571e-83	278.0	COG3315@1|root,COG3315@2|Bacteria,1TSGJ@1239|Firmicutes,24IYG@186801|Clostridia,36GVF@31979|Clostridiaceae	186801|Clostridia	Q	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity	-	-	-	-	-	-	-	-	-	-	-	-	LCM
HKD1_k127_360694_0	293826.Amet_2980	3.918e-218	685.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,36FNJ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	opuE	-	-	ko:K03307,ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21,2.A.21.2	-	-	SSF
HKD1_k127_360694_1	293826.Amet_2979	7.831e-10	61.0	COG5000@1|root,COG5000@2|Bacteria,1V3IT@1239|Firmicutes,249GI@186801|Clostridia,36FPA@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_361598_0	457396.CSBG_02286	5.35e-97	322.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,36EBM@31979|Clostridiaceae	186801|Clostridia	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iHN637.CLJU_RS12820	SBP_bac_11
HKD1_k127_36326_2	1121289.JHVL01000001_gene1850	2.876e-33	128.0	COG0254@1|root,COG0254@2|Bacteria,1VEGU@1239|Firmicutes,24QNZ@186801|Clostridia,36KES@31979|Clostridiaceae	186801|Clostridia	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD1_k127_36326_0	1304284.L21TH_0161	4.198e-195	619.0	COG1158@1|root,COG1158@2|Bacteria,1TPHZ@1239|Firmicutes,247YK@186801|Clostridia,36EED@31979|Clostridiaceae	186801|Clostridia	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD1_k127_36326_3	536232.CLM_1986	2.14e-24	104.0	COG1905@1|root,COG1905@2|Bacteria,1VFEK@1239|Firmicutes,24QMM@186801|Clostridia,36NC3@31979|Clostridiaceae	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	fhmD	-	-	-	-	-	-	-	-	-	-	-	2Fe-2S_thioredx
HKD1_k127_36326_1	1304284.L21TH_0542	1.607e-97	330.0	COG1145@1|root,COG4624@1|root,COG1145@2|Bacteria,COG4624@2|Bacteria,1TRB4@1239|Firmicutes,24BF5@186801|Clostridia,36E2Y@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_7,PAS
HKD1_k127_3635284_1	1487921.DP68_05210	1.485e-59	217.0	COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1TSVK@1239|Firmicutes,24CCA@186801|Clostridia,36HB1@31979|Clostridiaceae	186801|Clostridia	T	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	HATPase_c,HisKA,PAS_9,SBP_bac_3
HKD1_k127_3635284_0	1121289.JHVL01000031_gene357	1.374e-88	296.0	COG0624@1|root,COG0624@2|Bacteria,1TPMJ@1239|Firmicutes,25CA6@186801|Clostridia,36WS4@31979|Clostridiaceae	186801|Clostridia	E	Peptidase dimerisation domain	-	-	3.5.1.16	ko:K01438	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00669,R09107	RC00064,RC00300	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3638095_0	865861.AZSU01000003_gene1674	2.885e-172	557.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,36DSI@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD1_k127_3638095_1	1499689.CCNN01000007_gene1514	4.779e-31	124.0	COG0052@1|root,COG0052@2|Bacteria,1TPNA@1239|Firmicutes,247ZR@186801|Clostridia,36DHW@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD1_k127_3639260_1	1487921.DP68_03455	5.355e-67	234.0	2C2FW@1|root,32RAE@2|Bacteria,1V7TJ@1239|Firmicutes,25HSE@186801|Clostridia,36KTH@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3639260_0	1487921.DP68_06705	1.618e-246	766.0	COG2133@1|root,COG2133@2|Bacteria,1UIY2@1239|Firmicutes,24AGC@186801|Clostridia,36DGB@31979|Clostridiaceae	186801|Clostridia	G	pyrroloquinoline quinone binding	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD1_k127_3654211_0	1121324.CLIT_10c01240	3.025e-136	445.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,25QNA@186804|Peptostreptococcaceae	186801|Clostridia	E	homoserine dehydrogenase	hom	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD1_k127_3654211_1	1449342.JQMR01000001_gene1367	4.426e-102	341.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,4HB60@91061|Bacilli,27GAV@186828|Carnobacteriaceae	91061|Bacilli	K	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_3654211_2	1128398.Curi_c06150	7.715e-43	160.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,267XD@186813|unclassified Clostridiales	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_3658388_0	1151292.QEW_3905	2.895e-283	876.0	COG0525@1|root,COG0525@2|Bacteria,1TPN4@1239|Firmicutes,248VC@186801|Clostridia,25QNK@186804|Peptostreptococcaceae	186801|Clostridia	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD1_k127_3662645_0	272563.CD630_15470	3.326e-80	278.0	COG3705@1|root,COG3705@2|Bacteria,1TPZZ@1239|Firmicutes,248CB@186801|Clostridia,25SDG@186804|Peptostreptococcaceae	186801|Clostridia	E	Histidyl-tRNA synthetase	hisZ	-	-	ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002	-	-	-	tRNA-synt_His
HKD1_k127_3662645_1	272563.CD630_15480	1.795e-53	192.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,25T18@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD1_k127_3662999_0	1034769.KB910518_gene5106	4.293e-165	532.0	COG0642@1|root,COG3850@1|root,COG2205@2|Bacteria,COG3850@2|Bacteria,1V129@1239|Firmicutes,4ITS5@91061|Bacilli,277M2@186822|Paenibacillaceae	91061|Bacilli	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_3662999_1	1034769.KB910518_gene5105	3.523e-108	353.0	COG0745@1|root,COG0745@2|Bacteria,1TPRU@1239|Firmicutes,4HAX9@91061|Bacilli,26T4W@186822|Paenibacillaceae	91061|Bacilli	T	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_3662999_3	1123226.KB899286_gene3494	7.615e-61	220.0	28K0A@1|root,32QGI@2|Bacteria,1V77W@1239|Firmicutes,4HMIZ@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3662999_2	1123226.KB899286_gene3493	1.192e-90	304.0	COG1131@1|root,COG1131@2|Bacteria,1TP4J@1239|Firmicutes,4HJB9@91061|Bacilli,26VMM@186822|Paenibacillaceae	91061|Bacilli	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3662999_4	1123226.KB899286_gene3492	1.537e-45	173.0	COG1277@1|root,COG1277@2|Bacteria,1VI5K@1239|Firmicutes,4IRP3@91061|Bacilli	91061|Bacilli	S	ABC-2 family transporter protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_367196_3	1121289.JHVL01000002_gene2425	3.285e-15	78.0	COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia,36G4B@31979|Clostridiaceae	186801|Clostridia	S	heptaprenyl diphosphate synthase	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
HKD1_k127_367196_4	622312.ROSEINA2194_00898	7.651e-12	68.0	2C5I7@1|root,330HE@2|Bacteria,1VJU8@1239|Firmicutes,24SCX@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 9.75	-	-	-	-	-	-	-	-	-	-	-	-	DUF4321
HKD1_k127_367196_2	1128398.Curi_c10050	9.223e-54	195.0	COG0424@1|root,COG0424@2|Bacteria,1V6FH@1239|Firmicutes,24JRN@186801|Clostridia,2691F@186813|unclassified Clostridiales	186801|Clostridia	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD1_k127_367196_0	1304284.L21TH_2133	3.082e-81	277.0	COG2003@1|root,COG2003@2|Bacteria,1TQ3K@1239|Firmicutes,2498Z@186801|Clostridia,36DKZ@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the UPF0758 family	radC	-	-	ko:K03630	-	-	-	-	ko00000	-	-	-	RadC
HKD1_k127_367196_1	1408422.JHYF01000001_gene2911	2.752e-77	265.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_3681687_0	1414720.CBYM010000026_gene2397	1.843e-112	374.0	COG1061@1|root,COG3886@1|root,COG1061@2|Bacteria,COG3886@2|Bacteria,1TQ62@1239|Firmicutes,249TK@186801|Clostridia,36DKS@31979|Clostridiaceae	186801|Clostridia	L	helicase	-	-	-	-	-	-	-	-	-	-	-	-	DUF3427,Helicase_C,PLDc_2,ResIII
HKD1_k127_3681883_1	1211817.CCAT010000003_gene279	1.624e-06	53.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,36FNA@31979|Clostridiaceae	186801|Clostridia	S	SAM-dependent methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
HKD1_k127_3681883_0	655811.HMPREF0078_0920	1.144e-56	206.0	COG0327@1|root,COG0327@2|Bacteria,1TQ27@1239|Firmicutes,248Q2@186801|Clostridia,22GKT@1570339|Peptoniphilaceae	186801|Clostridia	S	Dinuclear metal center protein, YbgI family	-	-	-	-	-	-	-	-	-	-	-	-	NIF3
HKD1_k127_3682434_2	411902.CLOBOL_06269	2.999e-49	178.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,222QN@1506553|Lachnoclostridium	186801|Clostridia	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_3682434_0	264732.Moth_0383	2.64e-179	573.0	COG0471@1|root,COG0471@2|Bacteria,1TSP2@1239|Firmicutes,24DU3@186801|Clostridia,42HHC@68295|Thermoanaerobacterales	186801|Clostridia	P	Sodium:sulfate symporter transmembrane region	-	-	-	ko:K14445	-	-	-	-	ko00000,ko02000	2.A.47.1	-	-	Na_sulph_symp
HKD1_k127_3682434_1	1232410.KI421422_gene1947	5.468e-89	302.0	COG0280@1|root,COG0280@2|Bacteria,1QTXP@1224|Proteobacteria,42RGR@68525|delta/epsilon subdivisions,2WNWC@28221|Deltaproteobacteria,43UBY@69541|Desulfuromonadales	28221|Deltaproteobacteria	C	Phosphate acetyl/butaryl transferase	ptb	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	iAF987.Gmet_2098	PTA_PTB
HKD1_k127_368440_0	1230342.CTM_08171	2.738e-66	232.0	COG0662@1|root,COG0662@2|Bacteria,1V3H4@1239|Firmicutes,24HNT@186801|Clostridia,36EST@31979|Clostridiaceae	186801|Clostridia	G	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_3685655_0	1121289.JHVL01000013_gene1628	0.0	1437.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,36EA6@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_3685655_1	396513.SCA_1582	1.604e-07	54.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,4HACR@91061|Bacilli,4GXBW@90964|Staphylococcaceae	91061|Bacilli	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_3708229_2	398511.BpOF4_06525	3.06e-15	75.0	COG0451@1|root,COG0451@2|Bacteria,1VP6I@1239|Firmicutes,4HAN7@91061|Bacilli,1ZQ48@1386|Bacillus	91061|Bacilli	M	NAD-dependent epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD1_k127_3708229_1	1292035.H476_0593	7.652e-50	186.0	COG3944@1|root,COG3944@2|Bacteria,1UZCR@1239|Firmicutes,24HS8@186801|Clostridia,25RZQ@186804|Peptostreptococcaceae	186801|Clostridia	M	Chain length determinant protein	-	-	-	-	-	-	-	-	-	-	-	-	GNVR,Wzz
HKD1_k127_3708229_0	1123009.AUID01000003_gene1866	6.579e-58	208.0	COG0489@1|root,COG0489@2|Bacteria,1TS4R@1239|Firmicutes,24B0Z@186801|Clostridia,26CME@186813|unclassified Clostridiales	186801|Clostridia	D	ATPase MipZ	ywqD	-	-	-	-	-	-	-	-	-	-	-	AAA_31,ParA,Wzz
HKD1_k127_3709088_2	1410653.JHVC01000009_gene2752	2.911e-28	114.0	COG1307@1|root,COG1307@2|Bacteria,1TQQG@1239|Firmicutes,24EN6@186801|Clostridia,36FAC@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised protein, DegV family COG1307	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_3709088_1	1209989.TepiRe1_0390	1.034e-106	349.0	COG1489@1|root,COG1489@2|Bacteria,1V1GZ@1239|Firmicutes,24A0M@186801|Clostridia,42FFW@68295|Thermoanaerobacterales	186801|Clostridia	S	sugar fermentation stimulation protein	sfsA	-	-	ko:K06206	-	-	-	-	ko00000	-	-	-	SfsA
HKD1_k127_3709088_0	1347087.CBYO010000009_gene1343	5.57e-143	458.0	COG0384@1|root,COG0384@2|Bacteria,1TPPX@1239|Firmicutes,4IRC6@91061|Bacilli	91061|Bacilli	S	Phenazine biosynthesis-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PhzC-PhzF
HKD1_k127_3710517_0	1443125.Z962_01995	9.496e-30	120.0	COG1032@1|root,COG1032@2|Bacteria,1TPGT@1239|Firmicutes,247JS@186801|Clostridia,36DF6@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	-	-	1.21.98.3	ko:K04034	ko00860,ko01100,ko01110,map00860,map01100,map01110	-	R06268,R06269,R06270	RC00741,RC01491,RC01492	ko00000,ko00001,ko01000	-	-	-	B12-binding,DUF4080,Radical_SAM
HKD1_k127_3710517_2	1304284.L21TH_1048	7.015e-06	53.0	COG1397@1|root,COG1397@2|Bacteria,1V4ES@1239|Firmicutes,24HTU@186801|Clostridia,36IZG@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_3710517_1	865861.AZSU01000009_gene562	1.075e-11	71.0	COG1397@1|root,COG1397@2|Bacteria,1V4ES@1239|Firmicutes,24HTU@186801|Clostridia,36IZG@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_372069_0	428125.CLOLEP_03730	2.622e-216	678.0	COG1274@1|root,COG1274@2|Bacteria,1TQED@1239|Firmicutes,249NP@186801|Clostridia,3WGV6@541000|Ruminococcaceae	186801|Clostridia	H	Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle	pckG	-	4.1.1.32	ko:K01596	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003	R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_C,PEPCK_N
HKD1_k127_372069_1	293826.Amet_3704	1.854e-115	387.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae	186801|Clostridia	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
HKD1_k127_3723262_1	931626.Awo_c03860	1.494e-27	112.0	COG0695@1|root,COG0695@2|Bacteria,1UF2R@1239|Firmicutes,25NBW@186801|Clostridia,25Z45@186806|Eubacteriaceae	186801|Clostridia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_3723262_2	991905.SL003B_3762	9.622e-07	53.0	2DG40@1|root,2ZUDE@2|Bacteria,1PB4J@1224|Proteobacteria,2UYN6@28211|Alphaproteobacteria	991905.SL003B_3762|-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3723262_0	1321778.HMPREF1982_02880	1.098e-128	419.0	COG0460@1|root,COG0460@2|Bacteria,1TQ2H@1239|Firmicutes,248MU@186801|Clostridia,26822@186813|unclassified Clostridiales	186801|Clostridia	E	Homoserine dehydrogenase	-	-	1.1.1.3	ko:K00003	ko00260,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00017,M00018	R01773,R01775	RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,Homoserine_dh,NAD_binding_3
HKD1_k127_3733522_2	697303.Thewi_1345	1.274e-26	115.0	COG0196@1|root,COG0196@2|Bacteria,1TPKS@1239|Firmicutes,2484A@186801|Clostridia,42F98@68295|Thermoanaerobacterales	186801|Clostridia	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_3733522_1	865861.AZSU01000003_gene1734	7.104e-35	135.0	COG0184@1|root,COG0184@2|Bacteria,1VA5C@1239|Firmicutes,24MRM@186801|Clostridia,36KHC@31979|Clostridiaceae	186801|Clostridia	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD1_k127_3733522_0	1304284.L21TH_1343	3.155e-265	828.0	COG1185@1|root,COG1185@2|Bacteria,1TQDW@1239|Firmicutes,248RW@186801|Clostridia,36DDN@31979|Clostridiaceae	186801|Clostridia	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD1_k127_3739446_0	994573.T472_0218190	1.578e-43	163.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,36EB1@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily	-	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_3739446_1	335541.Swol_1189	2.315e-22	107.0	2ESSZ@1|root,33KBC@2|Bacteria,1VPF4@1239|Firmicutes,2531D@186801|Clostridia	186801|Clostridia	S	Bacterial Ig-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_5
HKD1_k127_3739446_2	1120998.AUFC01000006_gene878	2.815e-05	49.0	COG2041@1|root,COG3867@1|root,COG4733@1|root,COG5184@1|root,COG5492@1|root,COG2041@2|Bacteria,COG3867@2|Bacteria,COG4733@2|Bacteria,COG5184@2|Bacteria,COG5492@2|Bacteria,1UNSB@1239|Firmicutes,25H3W@186801|Clostridia,3WDUT@538999|Clostridiales incertae sedis	2|Bacteria	DZ	S-layer homology domain	-	-	3.2.1.14,3.2.1.22,3.2.1.23,3.2.1.89	ko:K01183,ko:K01190,ko:K01224,ko:K07407	ko00052,ko00511,ko00520,ko00561,ko00600,ko00603,ko01100,map00052,map00511,map00520,map00561,map00600,map00603,map01100	-	R01101,R01103,R01104,R01105,R01194,R01206,R01329,R01678,R02334,R02926,R03355,R03634,R04019,R04470,R04783,R05549,R05961,R06091,R06114	RC00049,RC00059,RC00451,RC00452,RC00467	ko00000,ko00001,ko01000	-	GH18	-	Big_2,F5_F8_type_C,Glyco_hydro_53,RCC1,RicinB_lectin_2,SLH,fn3
HKD1_k127_3756260_7	1120998.AUFC01000048_gene3026	1.859e-27	117.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HKD1_k127_3756260_6	641107.CDLVIII_1512	8.309e-43	162.0	COG1683@1|root,COG1683@2|Bacteria,1V700@1239|Firmicutes,24JD2@186801|Clostridia,36JUS@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF523)	-	-	-	-	-	-	-	-	-	-	-	-	DUF523
HKD1_k127_3756260_3	1304284.L21TH_1968	5.199e-62	218.0	COG1544@1|root,COG1544@2|Bacteria,1V1D5@1239|Firmicutes,24HDH@186801|Clostridia,36I5Z@31979|Clostridiaceae	186801|Clostridia	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	ko:K05808	-	-	-	-	ko00000,ko03009	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HKD1_k127_3756260_2	1209989.TepiRe1_0546	1.841e-77	263.0	COG1838@1|root,COG1838@2|Bacteria,1V1CP@1239|Firmicutes,24FRK@186801|Clostridia,42FEX@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM hydro-lyase, Fe-S type, tartrate fumarate subfamily, beta subunit	fumB	-	4.2.1.2	ko:K01678	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase_C
HKD1_k127_3756260_0	1209989.TepiRe1_0545	5.041e-114	373.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,42EX5@68295|Thermoanaerobacterales	186801|Clostridia	C	hydro-lyase, Fe-S type, tartrate fumarate subfamily, alpha subunit	-	-	4.2.1.2	ko:K01677	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	Fumerase
HKD1_k127_3756260_4	645991.Sgly_1672	2.059e-46	172.0	COG1418@1|root,COG1418@2|Bacteria,1V4QX@1239|Firmicutes,24JBS@186801|Clostridia,264ZS@186807|Peptococcaceae	186801|Clostridia	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_3756260_1	1304284.L21TH_0072	8.361e-111	376.0	COG0739@1|root,COG3583@1|root,COG0739@2|Bacteria,COG3583@2|Bacteria,1TRWJ@1239|Firmicutes,24A2J@186801|Clostridia,36HF8@31979|Clostridiaceae	186801|Clostridia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	G5,LysM,Peptidase_M23
HKD1_k127_3756260_5	1304284.L21TH_0074	6.877e-43	164.0	COG3935@1|root,COG3935@2|Bacteria,1TPR5@1239|Firmicutes,248E7@186801|Clostridia,36F7E@31979|Clostridiaceae	186801|Clostridia	L	DNA replication protein DnaD	dnaD	-	-	-	-	-	-	-	-	-	-	-	DnaB_2
HKD1_k127_375943_0	1243664.CAVL020000038_gene853	7.575e-105	357.0	COG2898@1|root,COG2898@2|Bacteria,1U5FR@1239|Firmicutes,4HDGF@91061|Bacilli,1ZRB3@1386|Bacillus	91061|Bacilli	S	Psort location CytoplasmicMembrane, score	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran_2
HKD1_k127_376571_0	767817.Desgi_3255	2.081e-52	190.0	COG2761@1|root,COG2761@2|Bacteria,1TRSS@1239|Firmicutes,25D1S@186801|Clostridia	186801|Clostridia	Q	DSBA-like thioredoxin domain	-	-	-	-	-	-	-	-	-	-	-	-	DSBA
HKD1_k127_376571_1	1280390.CBQR020000073_gene1572	5.207e-10	63.0	COG0778@1|root,COG0778@2|Bacteria,1UY72@1239|Firmicutes,4HI6B@91061|Bacilli,26RWF@186822|Paenibacillaceae	91061|Bacilli	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_376851_0	768710.DesyoDRAFT_1257	1.733e-40	153.0	COG1720@1|root,COG1720@2|Bacteria,1TSBR@1239|Firmicutes,247X5@186801|Clostridia,262Z9@186807|Peptococcaceae	186801|Clostridia	S	PFAM Uncharacterised protein family UPF0066	-	-	-	-	-	-	-	-	-	-	-	-	UPF0066
HKD1_k127_378064_1	865861.AZSU01000004_gene1045	3.138e-69	237.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	oppF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_378064_0	1209989.TepiRe1_0848	5.107e-139	445.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,42F1U@68295|Thermoanaerobacterales	186801|Clostridia	P	Belongs to the ABC transporter superfamily	-	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_3785249_0	411490.ANACAC_03684	9.422e-163	516.0	COG0056@1|root,COG0056@2|Bacteria,1TNZ8@1239|Firmicutes,248IY@186801|Clostridia	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N,OSCP
HKD1_k127_3785249_1	537007.BLAHAN_04006	4.295e-41	156.0	COG0712@1|root,COG0712@2|Bacteria,1UI0C@1239|Firmicutes,24G5C@186801|Clostridia,3Y09Z@572511|Blautia	186801|Clostridia	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD1_k127_3785249_2	1286171.EAL2_c03880	2.251e-16	83.0	COG0711@1|root,COG0711@2|Bacteria,1VB85@1239|Firmicutes,24RWR@186801|Clostridia,25X82@186806|Eubacteriaceae	186801|Clostridia	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	iHN637.CLJU_RS01170	ATP-synt_B
HKD1_k127_3785813_3	1408304.JAHA01000003_gene3175	7.484e-21	94.0	COG0215@1|root,COG0215@2|Bacteria,1TP9D@1239|Firmicutes,247KS@186801|Clostridia,4BWZK@830|Butyrivibrio	186801|Clostridia	J	tRNA synthetases class I (C) catalytic domain	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e,tRNA-synt_1g
HKD1_k127_3785813_2	272562.CA_C3156	1.157e-33	139.0	COG1939@1|root,COG1939@2|Bacteria,1VA5V@1239|Firmicutes,24MR1@186801|Clostridia,36JIS@31979|Clostridiaceae	186801|Clostridia	J	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)	mrnC	-	-	ko:K11145	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Ribonuclease_3
HKD1_k127_3785813_0	1121289.JHVL01000023_gene49	1.838e-89	301.0	COG0566@1|root,COG0566@2|Bacteria,1TP9G@1239|Firmicutes,247SC@186801|Clostridia,36DW4@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	yacO	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD1_k127_3785813_1	1121289.JHVL01000023_gene48	3.015e-52	189.0	COG3688@1|root,COG3688@2|Bacteria,1V9XR@1239|Firmicutes,24MPI@186801|Clostridia,36I6R@31979|Clostridiaceae	186801|Clostridia	S	RNA-binding protein	-	-	-	ko:K06962	-	-	-	-	ko00000	-	-	-	NYN_YacP
HKD1_k127_3792359_0	1121101.HMPREF1532_04075	6.264e-53	205.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SLH
HKD1_k127_3792359_1	1499968.TCA2_4799	3.329e-40	167.0	COG0671@1|root,COG5492@1|root,COG0671@2|Bacteria,COG5492@2|Bacteria,1UYVP@1239|Firmicutes,4HF6D@91061|Bacilli,26V0P@186822|Paenibacillaceae	91061|Bacilli	I	Membrane-associated phospholipid phosphatase	epsA	-	-	-	-	-	-	-	-	-	-	-	PAP2,PATR,SLH
HKD1_k127_3800276_1	1128398.Curi_c12340	4.153e-101	332.0	COG0059@1|root,COG0059@2|Bacteria,1TPI7@1239|Firmicutes,247RH@186801|Clostridia,267TH@186813|unclassified Clostridiales	186801|Clostridia	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	ilvC	-	1.1.1.86	ko:K00053	ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R03051,R04439,R04440,R05068,R05069,R05071	RC00726,RC00836,RC00837,RC01726	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS10005,iHN637.CLJU_RS10010	IlvC,IlvN
HKD1_k127_3800276_0	1121289.JHVL01000035_gene2624	1.799e-140	457.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,36DNN@31979|Clostridiaceae	186801|Clostridia	H	Acetolactate synthase, large subunit	ilvB	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_380831_0	1408422.JHYF01000016_gene123	4.679e-90	300.0	COG0075@1|root,COG0075@2|Bacteria,1TPS0@1239|Firmicutes,24919@186801|Clostridia,36E72@31979|Clostridiaceae	186801|Clostridia	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_3823756_0	1304284.L21TH_0017	5.941e-114	370.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia,36DPI@31979|Clostridiaceae	186801|Clostridia	S	beta-keto acid cleavage enzyme	kce	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
HKD1_k127_3823756_1	1304284.L21TH_0162	3.226e-102	336.0	COG1494@1|root,COG1494@2|Bacteria,1TP0D@1239|Firmicutes,249PW@186801|Clostridia,36E1S@31979|Clostridiaceae	186801|Clostridia	G	Fructose-1,6-bisphosphatase	glpX	-	3.1.3.11	ko:K02446	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD1_k127_382470_1	641107.CDLVIII_1205	2.45e-128	412.0	COG0421@1|root,COG0421@2|Bacteria,1TPG5@1239|Firmicutes,24827@186801|Clostridia,36FAN@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine	speE	-	2.5.1.16	ko:K00797	ko00270,ko00330,ko00410,ko00480,ko01100,map00270,map00330,map00410,map00480,map01100	M00034,M00133	R01920,R02869,R08359	RC00021,RC00053	ko00000,ko00001,ko00002,ko01000	-	-	-	Spermine_synt_N,Spermine_synth
HKD1_k127_382470_0	1345695.CLSA_c08490	5.666e-134	431.0	COG0010@1|root,COG0010@2|Bacteria,1TP2A@1239|Firmicutes,2493V@186801|Clostridia,36U5Z@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the arginase family	speB	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD1_k127_382470_2	641107.CDLVIII_1206	5.434e-87	288.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,24AHW@186801|Clostridia,36DU9@31979|Clostridiaceae	186801|Clostridia	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HKD1_k127_3828423_0	546269.HMPREF0389_01652	4.119e-125	411.0	COG1058@1|root,COG1546@1|root,COG1058@2|Bacteria,COG1546@2|Bacteria,1TQ1N@1239|Firmicutes,249WC@186801|Clostridia,25QFY@186804|Peptostreptococcaceae	186801|Clostridia	S	Belongs to the CinA family	cinA	-	3.5.1.42	ko:K03742,ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA,MoCF_biosynth
HKD1_k127_3831908_2	1262449.CP6013_0425	1.769e-13	77.0	COG1295@1|root,COG1295@2|Bacteria,1U7HM@1239|Firmicutes,24A2Q@186801|Clostridia,36ESU@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0761 family	yihY	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD1_k127_3831908_0	709991.Odosp_3183	8.208e-124	402.0	COG1250@1|root,COG1250@2|Bacteria,4NGU8@976|Bacteroidetes,2FPSD@200643|Bacteroidia,22W85@171551|Porphyromonadaceae	976|Bacteroidetes	C	3-hydroxybutyryl-CoA dehydrogenase	hbd	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_3831908_1	457396.CSBG_00552	5.346e-40	152.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,36JKN@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD1_k127_3832873_0	203119.Cthe_3016	1.571e-164	524.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,3WHQ8@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD1_k127_3833410_2	1196322.A370_02827	2.916e-184	583.0	COG1145@1|root,COG1145@2|Bacteria,1UJPE@1239|Firmicutes,25F7J@186801|Clostridia,36V92@31979|Clostridiaceae	186801|Clostridia	C	4fe-4S ferredoxin, iron-sulfur binding domain protein	-	-	1.97.1.9	ko:K12527	ko00450,map00450	-	R07229	RC02420	ko00000,ko00001,ko01000	-	-	-	-
HKD1_k127_3833410_0	994573.T472_0214815	2.525e-253	784.0	COG0624@1|root,COG0624@2|Bacteria,1TR99@1239|Firmicutes,248DC@186801|Clostridia,36G77@31979|Clostridiaceae	186801|Clostridia	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_3833410_1	1158609.I586_01783	2.466e-215	672.0	COG0078@1|root,COG0078@2|Bacteria,1TNY4@1239|Firmicutes,4HEI4@91061|Bacilli,4B20G@81852|Enterococcaceae	91061|Bacilli	E	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain	-	-	-	-	-	-	-	-	-	-	-	-	OTCace,OTCace_N
HKD1_k127_3848473_1	1216932.CM240_1779	4.638e-57	207.0	COG0546@1|root,COG0546@2|Bacteria,1V92U@1239|Firmicutes,24IJR@186801|Clostridia	186801|Clostridia	S	HAD hydrolase, family IA, variant	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_3848473_0	1499683.CCFF01000017_gene1603	2.802e-102	338.0	COG0020@1|root,COG0020@2|Bacteria,1TRKB@1239|Firmicutes,248R2@186801|Clostridia,36EV1@31979|Clostridiaceae	186801|Clostridia	I	undecaprenyl	uppS1	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_38553_3	720554.Clocl_3241	1.106e-14	76.0	2DS93@1|root,33F25@2|Bacteria,1VKBP@1239|Firmicutes,24RSQ@186801|Clostridia,3WQ4N@541000|Ruminococcaceae	186801|Clostridia	S	Domain of Unknown Function (DUF1540)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1540
HKD1_k127_38553_1	189425.PGRAT_23480	2.297e-153	496.0	COG3385@1|root,COG3385@2|Bacteria,1UTR4@1239|Firmicutes,4HG6W@91061|Bacilli	91061|Bacilli	L	FOG Transposase and inactivated	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD1_k127_38553_2	1410653.JHVC01000007_gene626	6.334e-49	176.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24NFX@186801|Clostridia,36K0Z@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD1_k127_38553_0	86416.Clopa_3678	1.151e-160	515.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,36EN6@31979|Clostridiaceae	186801|Clostridia	L	exonuclease	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
HKD1_k127_385820_0	871968.DESME_04140	0.0	1016.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_3858332_1	1347086.CCBA010000039_gene4730	6.405e-11	64.0	29S3X@1|root,30D8D@2|Bacteria,1UAZD@1239|Firmicutes,4IMCB@91061|Bacilli,1ZJSN@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3858332_4	468059.AUHA01000003_gene2021	0.0001273	45.0	COG1961@1|root,COG1961@2|Bacteria,4NFJA@976|Bacteroidetes,1IPXM@117747|Sphingobacteriia	976|Bacteroidetes	L	PFAM Resolvase, N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD1_k127_3858332_0	350688.Clos_0947	9.005e-86	290.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36FU2@31979|Clostridiaceae	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_3863197_3	1540257.JQMW01000009_gene3015	9.669e-79	270.0	COG2071@1|root,COG2071@2|Bacteria,1V1KC@1239|Firmicutes,24JCU@186801|Clostridia,36DTE@31979|Clostridiaceae	186801|Clostridia	S	Peptidase C26	ntpR	-	-	ko:K07010	-	-	-	-	ko00000,ko01002	-	-	-	Peptidase_C26
HKD1_k127_3863197_1	871968.DESME_15000	1.372e-161	511.0	COG4667@1|root,COG4667@2|Bacteria,1TQ9W@1239|Firmicutes,2485C@186801|Clostridia,264AY@186807|Peptococcaceae	186801|Clostridia	S	esterase of the alpha-beta hydrolase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Patatin
HKD1_k127_3863197_2	1211814.CAPG01000008_gene260	6.58e-142	462.0	COG0436@1|root,COG0436@2|Bacteria,1TP0J@1239|Firmicutes,4HA13@91061|Bacilli,1ZAWQ@1386|Bacillus	91061|Bacilli	E	Aminotransferase	patA	-	-	ko:K00841	ko00300,ko01100,ko01110,ko01230,map00300,map01100,map01110,map01230	M00525	R04467	RC00006	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_3863197_0	1321781.HMPREF1985_01480	4.005e-173	548.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,4H2DP@909932|Negativicutes	909932|Negativicutes	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_3863197_4	1321781.HMPREF1985_01485	1.032e-55	197.0	COG0191@1|root,COG0191@2|Bacteria,1TRS4@1239|Firmicutes,4H3EE@909932|Negativicutes	909932|Negativicutes	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_387109_0	293826.Amet_2978	9.611e-149	480.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,36EVK@31979|Clostridiaceae	186801|Clostridia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_3890594_0	1230342.CTM_18934	4.965e-201	635.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_3890594_1	1230342.CTM_18929	8.907e-08	55.0	COG1846@1|root,COG1846@2|Bacteria,1VEFZ@1239|Firmicutes,24MSB@186801|Clostridia,36N2T@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_389643_1	1121344.JHZO01000006_gene1969	1.255e-49	183.0	COG0791@1|root,COG0791@2|Bacteria,1V9ZW@1239|Firmicutes,249UE@186801|Clostridia,3WJGR@541000|Ruminococcaceae	186801|Clostridia	M	SH3 type 3 domain protein	-	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	NLPC_P60,SH3_3
HKD1_k127_389643_0	345219.Bcoa_0726	2.108e-59	211.0	COG1309@1|root,COG1309@2|Bacteria,1VG3M@1239|Firmicutes,4IPKT@91061|Bacilli,1ZRC2@1386|Bacillus	91061|Bacilli	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_390896_2	293826.Amet_0765	1.664e-21	94.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,36EI7@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_390896_0	386415.NT01CX_1206	2.31e-163	530.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36QTE@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.2.4,1.1.3.15	ko:K00102,ko:K00104	ko00620,ko00630,ko01100,ko01110,ko01120,ko01130,map00620,map00630,map01100,map01110,map01120,map01130	-	R00197,R00475	RC00042,RC00044	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_390896_1	742741.HMPREF9475_00136	1.232e-161	517.0	COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia	186801|Clostridia	P	Catalyzes the sodium-dependent transport of glutamate	gltS	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HKD1_k127_3918375_0	1449343.JQLQ01000002_gene623	1.84e-65	231.0	COG1767@1|root,COG1767@2|Bacteria,1TQGQ@1239|Firmicutes,4HGCS@91061|Bacilli,27HD4@186828|Carnobacteriaceae	91061|Bacilli	H	ATP:dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
HKD1_k127_3918375_1	862517.HMPREF9225_1187	4.393e-21	96.0	COG3697@1|root,COG3697@2|Bacteria,1VB3E@1239|Firmicutes,24NQS@186801|Clostridia	186801|Clostridia	HI	Holo-ACP synthase CitX	citX	-	2.7.7.61	ko:K05964	ko02020,map02020	-	R10706	-	ko00000,ko00001,ko01000	-	-	-	CitX
HKD1_k127_3924311_0	1321778.HMPREF1982_02894	9.297e-90	311.0	COG1409@1|root,COG1409@2|Bacteria,1UQCQ@1239|Firmicutes,248P1@186801|Clostridia	186801|Clostridia	M	Ser Thr phosphatase family protein	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_3934480_2	1410668.JNKC01000001_gene1922	9.88e-35	135.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1URF2@1239|Firmicutes,24KCB@186801|Clostridia,36VHR@31979|Clostridiaceae	186801|Clostridia	T	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18,Response_reg
HKD1_k127_3934480_0	1410668.JNKC01000001_gene1921	1.062e-175	567.0	COG2972@1|root,COG2972@2|Bacteria,1TPVR@1239|Firmicutes,247XB@186801|Clostridia,36FRE@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	2.7.13.3	ko:K07718	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,His_kinase,dCache_1
HKD1_k127_3934480_1	1410668.JNKC01000001_gene1920	6.596e-45	169.0	COG1053@1|root,COG1053@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36DR3@31979|Clostridiaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4,1.3.99.33	ko:K00239,ko:K00244,ko:K17363	ko00020,ko00190,ko00340,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00340,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164,R10330	RC00045,RC00669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
HKD1_k127_3937754_1	1304284.L21TH_0311	5.745e-87	295.0	COG3437@1|root,COG3437@2|Bacteria,1UJGR@1239|Firmicutes,25F2H@186801|Clostridia,36UW4@31979|Clostridiaceae	186801|Clostridia	T	YcbB domain	-	-	-	ko:K07719	ko02020,map02020	M00518	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,YcbB
HKD1_k127_3937754_0	555079.Toce_0459	2.518e-99	338.0	COG0642@1|root,COG2205@2|Bacteria,1UITD@1239|Firmicutes,25EZC@186801|Clostridia	186801|Clostridia	T	PFAM ATP-binding region	-	-	2.7.13.3	ko:K07717	ko02020,map02020	M00518	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c
HKD1_k127_3950049_1	1120746.CCNL01000011_gene1477	1.81e-28	119.0	COG1843@1|root,COG1843@2|Bacteria	2|Bacteria	N	Required for flagellar hook formation. May act as a scaffolding protein	flgD	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02389	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FLgD_tudor,FlgD,FlgD_ig
HKD1_k127_3950049_2	398512.JQKC01000007_gene1140	3.887e-24	106.0	2E35U@1|root,32Y5R@2|Bacteria,1VEH9@1239|Firmicutes,24R2S@186801|Clostridia,3WKKM@541000|Ruminococcaceae	186801|Clostridia	N	TIGRFAM flagellar operon protein	flg	-	-	-	-	-	-	-	-	-	-	-	Flagellar_put
HKD1_k127_3950049_0	1121334.KB911069_gene1599	3.767e-47	173.0	COG1749@1|root,COG1749@2|Bacteria,1UHS7@1239|Firmicutes,247ZT@186801|Clostridia,3WHDY@541000|Ruminococcaceae	186801|Clostridia	N	Flagellar hook protein FlgE	flgE	-	-	ko:K02390	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FlaE,Flg_bb_rod,Flg_bbr_C
HKD1_k127_3951686_2	1410625.JHWK01000007_gene2179	4.791e-38	143.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,27JHP@186928|unclassified Lachnospiraceae	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_3951686_0	1511.CLOST_0223	1.155e-74	255.0	COG1704@1|root,COG1704@2|Bacteria,1V3Z0@1239|Firmicutes,24IH4@186801|Clostridia	186801|Clostridia	S	LemA family	lemA	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD1_k127_3951686_1	1511.CLOST_0222	8.276e-58	210.0	COG1512@1|root,COG1512@2|Bacteria,1V5YF@1239|Firmicutes,249DU@186801|Clostridia	186801|Clostridia	S	methanol dehydrogenase	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD1_k127_3969724_2	428127.EUBDOL_00318	4.258e-09	59.0	COG1080@1|root,COG1080@2|Bacteria,1TPK8@1239|Firmicutes,3VNU4@526524|Erysipelotrichia	526524|Erysipelotrichia	G	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)	ptsP	-	2.7.3.9	ko:K08483	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	8.A.7	-	-	PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD1_k127_3969724_0	1121324.CLIT_2c02670	1.096e-56	203.0	COG0655@1|root,COG0655@2|Bacteria	2|Bacteria	S	NAD(P)H dehydrogenase (quinone) activity	wrbA	GO:0003674,GO:0003824,GO:0008150,GO:0008152,GO:0016491,GO:0055114	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1,Flavodoxin_5,YjgF_endoribonc
HKD1_k127_3969724_1	318464.IO99_13890	9.891e-13	71.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36E34@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_3982507_0	871968.DESME_14905	2.55e-199	631.0	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,26099@186807|Peptococcaceae	186801|Clostridia	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD1_k127_3991353_0	1329516.JPST01000036_gene3054	6.825e-119	391.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,27B3V@186824|Thermoactinomycetaceae	91061|Bacilli	KT	Bacterial regulatory protein, Fis family	bkdR	-	-	-	-	-	-	-	-	-	-	-	DapB_N,HTH_8,PAS,Sigma54_activat
HKD1_k127_3991353_1	1196322.A370_04345	5.187e-48	175.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36EGP@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the acetokinase family	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD1_k127_3994283_5	293826.Amet_4210	4.757e-21	95.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,36DIP@31979|Clostridiaceae	186801|Clostridia	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_3994283_3	1347392.CCEZ01000026_gene2999	1.251e-37	145.0	COG0642@1|root,COG2205@2|Bacteria,1VA0N@1239|Firmicutes,24M86@186801|Clostridia,36MG9@31979|Clostridiaceae	186801|Clostridia	T	protein histidine kinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD1_k127_3994283_6	1304284.L21TH_1450	1.865e-20	96.0	COG3339@1|root,COG3339@2|Bacteria,1UGM4@1239|Firmicutes,25P3Y@186801|Clostridia,36TU1@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1232
HKD1_k127_3994283_4	1304284.L21TH_1449	1.352e-27	128.0	2F0R9@1|root,33TTN@2|Bacteria,1VUUA@1239|Firmicutes,250MJ@186801|Clostridia,36RQ1@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_3994283_1	1304284.L21TH_1503	7.589e-95	316.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36H16@31979|Clostridiaceae	186801|Clostridia	V	ATPases associated with a variety of cellular activities	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_3994283_0	1304284.L21TH_1502	1.227e-112	385.0	COG0845@1|root,COG0845@2|Bacteria,1TT2M@1239|Firmicutes,24BJV@186801|Clostridia,36H6P@31979|Clostridiaceae	186801|Clostridia	M	Barrel-sandwich domain of CusB or HlyD membrane-fusion	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_3994283_2	1304284.L21TH_1501	3.965e-88	300.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,24DV9@186801|Clostridia,36H98@31979|Clostridiaceae	186801|Clostridia	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_3998878_2	1304284.L21TH_0607	3.998e-50	181.0	COG2001@1|root,COG2001@2|Bacteria,1V3JD@1239|Firmicutes,24HB9@186801|Clostridia,36I1C@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the MraZ family	mraZ	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD1_k127_3998878_0	1304284.L21TH_0608	1.135e-126	411.0	COG0275@1|root,COG0275@2|Bacteria,1TNZV@1239|Firmicutes,248B5@186801|Clostridia,36E4H@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD1_k127_3998878_3	865861.AZSU01000003_gene1945	5.406e-10	66.0	COG2919@1|root,COG2919@2|Bacteria	2|Bacteria	D	cell cycle	divIC	-	-	ko:K05589,ko:K12065,ko:K13052	-	-	-	-	ko00000,ko02044,ko03036	3.A.7.11.1	-	-	DivIC
HKD1_k127_3998878_1	1304284.L21TH_0610	2.44e-54	200.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,36DJT@31979|Clostridiaceae	186801|Clostridia	M	stage V sporulation protein D	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD1_k127_400901_1	1511.CLOST_0902	2.779e-70	241.0	COG4124@1|root,COG4124@2|Bacteria,1U8S3@1239|Firmicutes,24C93@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolase family 26	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HKD1_k127_400901_0	398512.JQKC01000004_gene5250	9.286e-111	361.0	COG0745@1|root,COG0745@2|Bacteria,1TP9M@1239|Firmicutes,247TK@186801|Clostridia,3WHIA@541000|Ruminococcaceae	186801|Clostridia	T	response regulator receiver	phoP_1	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_400901_2	138119.DSY1785	3.408e-52	204.0	COG5002@1|root,COG5002@2|Bacteria,1UM03@1239|Firmicutes,24F2S@186801|Clostridia,267AH@186807|Peptococcaceae	186801|Clostridia	T	PFAM Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_4013964_0	537007.BLAHAN_05052	0.0	1128.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,3Y156@572511|Blautia	186801|Clostridia	E	Urocanase C-terminal domain	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD1_k127_4013964_1	1123009.AUID01000001_gene1111	3.077e-133	427.0	COG3643@1|root,COG3643@2|Bacteria,1TP5T@1239|Firmicutes,24905@186801|Clostridia,268T0@186813|unclassified Clostridiales	186801|Clostridia	E	Formiminotransferase domain, N-terminal subdomain	ftcD	-	2.1.2.5	ko:K00603	ko00340,ko00670,ko01100,map00340,map00670,map01100	-	R02287,R03189	RC00165,RC00221,RC00223,RC00870	ko00000,ko00001,ko01000	-	-	-	FTCD,FTCD_N
HKD1_k127_4014422_0	865861.AZSU01000006_gene1267	4.611e-93	325.0	28HMX@1|root,2Z7WB@2|Bacteria,1TPJG@1239|Firmicutes,24AWI@186801|Clostridia,36FCX@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4014422_1	293826.Amet_1438	4.566e-75	262.0	2A4QQ@1|root,30TC0@2|Bacteria,1V4P8@1239|Firmicutes,24ID5@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4014422_2	318464.IO99_06535	2.779e-66	228.0	COG0251@1|root,COG0251@2|Bacteria,1VVJ9@1239|Firmicutes,24G4V@186801|Clostridia,36I89@31979|Clostridiaceae	186801|Clostridia	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD1_k127_4024010_0	645991.Sgly_0375	1.18e-109	372.0	COG0840@1|root,COG2221@1|root,COG4624@1|root,COG0840@2|Bacteria,COG2221@2|Bacteria,COG4624@2|Bacteria,1TSVR@1239|Firmicutes,248TC@186801|Clostridia,262ME@186807|Peptococcaceae	186801|Clostridia	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	FeS,Fe_hyd_lg_C,Fer4,Fer4_10,Fer4_7,MCPsignal
HKD1_k127_4024010_1	1469948.JPNB01000002_gene3780	2.792e-12	68.0	2DIV4@1|root,30473@2|Bacteria,1V5EC@1239|Firmicutes,24IZE@186801|Clostridia,36K7X@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_402919_1	555079.Toce_0538	1.049e-48	176.0	COG0822@1|root,COG0822@2|Bacteria,1V3H9@1239|Firmicutes,24HDD@186801|Clostridia,42GNH@68295|Thermoanaerobacterales	186801|Clostridia	C	TIGRFAM FeS cluster assembly scaffold protein NifU	-	-	-	ko:K04488	-	-	-	-	ko00000	-	-	-	NifU_N
HKD1_k127_402919_0	1123288.SOV_1c05660	2.519e-128	425.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,4H245@909932|Negativicutes	909932|Negativicutes	H	ThiF family	-	-	-	-	-	-	-	-	-	-	-	-	ThiF
HKD1_k127_4032824_0	1120746.CCNL01000010_gene1349	2.718e-156	496.0	COG0474@1|root,COG0474@2|Bacteria,2NQM6@2323|unclassified Bacteria	2|Bacteria	P	Cation transporter/ATPase, N-terminus	pacL	-	3.6.3.8,3.6.3.9	ko:K01537,ko:K01539	ko04022,ko04024,ko04260,ko04261,ko04911,ko04918,ko04919,ko04925,ko04960,ko04961,ko04964,ko04970,ko04971,ko04972,ko04973,ko04974,ko04976,ko04978,map04022,map04024,map04260,map04261,map04911,map04918,map04919,map04925,map04960,map04961,map04964,map04970,map04971,map04972,map04973,map04974,map04976,map04978	-	-	-	ko00000,ko00001,ko01000,ko04147	3.A.3.1,3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_4032824_1	1120746.CCNL01000010_gene1350	6.481e-98	323.0	COG0569@1|root,COG0569@2|Bacteria,2NPXT@2323|unclassified Bacteria	2|Bacteria	P	TrkA-N domain	-	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_403420_1	1089553.Tph_c04220	2.655e-32	130.0	COG3383@1|root,COG3383@2|Bacteria,1V5BD@1239|Firmicutes,24ER9@186801|Clostridia	186801|Clostridia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03470	Fer2_4,Fer4,Fer4_21,Fer4_7
HKD1_k127_403420_0	1120998.AUFC01000002_gene2719	3.273e-270	843.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD1_k127_403420_2	411468.CLOSCI_03471	4.175e-14	73.0	COG1905@1|root,COG1905@2|Bacteria,1V4IR@1239|Firmicutes,25CD0@186801|Clostridia,220KF@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_4036664_0	1128398.Curi_c10370	6.026e-108	357.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,267UM@186813|unclassified Clostridiales	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_4036664_1	1304284.L21TH_1305	6.598e-46	173.0	2B51H@1|root,31XUS@2|Bacteria,1V6KA@1239|Firmicutes,24JQP@186801|Clostridia,36HST@31979|Clostridiaceae	186801|Clostridia	S	sporulation protein YunB	yunB	-	-	-	-	-	-	-	-	-	-	-	Spore_YunB
HKD1_k127_4036664_2	1347392.CCEZ01000043_gene128	4.231e-12	69.0	COG5009@1|root,COG5009@2|Bacteria,1UI0H@1239|Firmicutes,25E95@186801|Clostridia,36UN0@31979|Clostridiaceae	186801|Clostridia	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_4039465_0	485916.Dtox_2165	1.574e-93	307.0	28NIH@1|root,2ZBJX@2|Bacteria,1V1SN@1239|Firmicutes,24DH3@186801|Clostridia,261JZ@186807|Peptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4039465_1	536227.CcarbDRAFT_3717	4.801e-74	259.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,Response_reg,dCache_1
HKD1_k127_4045749_0	1304284.L21TH_0439	5.295e-282	898.0	COG5009@1|root,COG5009@2|Bacteria,1UI0H@1239|Firmicutes,25E95@186801|Clostridia,36UN0@31979|Clostridiaceae	186801|Clostridia	M	Transglycosylase	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD1_k127_4045749_1	457396.CSBG_02469	1.971e-34	135.0	2ANER@1|root,315MJ@2|Bacteria,1V6SU@1239|Firmicutes,24JBZ@186801|Clostridia,36JME@31979|Clostridiaceae	186801|Clostridia	S	stage V sporulation protein	spoVAE	-	-	ko:K06407	-	-	-	-	ko00000	-	-	-	SpoVAC_SpoVAEB
HKD1_k127_405224_0	1120746.CCNL01000016_gene2317	7.584e-101	332.0	COG2855@1|root,COG2855@2|Bacteria,2NPZ2@2323|unclassified Bacteria	2|Bacteria	S	Conserved hypothetical protein 698	yeiH	-	-	-	-	-	-	-	-	-	-	-	Cons_hypoth698
HKD1_k127_405224_1	536227.CcarbDRAFT_3746	1.833e-91	305.0	COG0583@1|root,COG0583@2|Bacteria,1TP6T@1239|Firmicutes,24970@186801|Clostridia,36FHV@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4055724_0	1410612.JNKO01000010_gene428	3.655e-196	620.0	COG1048@1|root,COG1048@2|Bacteria,1VTMM@1239|Firmicutes,25HJM@186801|Clostridia,2PTB5@265975|Oribacterium	186801|Clostridia	C	Aconitase family (aconitate hydratase)	-	-	-	-	-	-	-	-	-	-	-	-	Aconitase,Aconitase_C
HKD1_k127_4055724_2	1391647.AVSV01000028_gene284	2.84e-22	102.0	2E70J@1|root,331JD@2|Bacteria,1VGGS@1239|Firmicutes,24JJ2@186801|Clostridia,36JT3@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4055724_1	1321778.HMPREF1982_03136	1.7e-80	278.0	COG2206@1|root,COG2206@2|Bacteria,1UZN2@1239|Firmicutes,248SE@186801|Clostridia,268YS@186813|unclassified Clostridiales	186801|Clostridia	T	K03540 ribonuclease P protein subunit RPR2	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,MEDS,PAS_4,PAS_9
HKD1_k127_4066838_5	387092.NIS_0550	4.845e-23	109.0	COG2199@1|root,COG3706@2|Bacteria,1MX83@1224|Proteobacteria,43AP6@68525|delta/epsilon subdivisions,2YT2M@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	T	Cache domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,dCache_1
HKD1_k127_4066838_4	445973.CLOBAR_01477	1.348e-41	161.0	COG2137@1|root,COG2137@2|Bacteria,1V72V@1239|Firmicutes,24KZH@186801|Clostridia,25RI7@186804|Peptostreptococcaceae	186801|Clostridia	S	Modulates RecA activity	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD1_k127_4066838_3	1297617.JPJD01000034_gene708	1.613e-48	177.0	COG1607@1|root,COG1607@2|Bacteria,1VD4Z@1239|Firmicutes	1239|Firmicutes	I	Thioesterase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD1_k127_4066838_2	1449050.JNLE01000003_gene2654	5.734e-98	329.0	COG0341@1|root,COG0341@2|Bacteria,1TSZE@1239|Firmicutes,249A3@186801|Clostridia,36ETH@31979|Clostridiaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD1_k127_4066838_1	645991.Sgly_1811	1.695e-153	495.0	COG0342@1|root,COG0342@2|Bacteria,1TQVT@1239|Firmicutes,247X8@186801|Clostridia,260H2@186807|Peptococcaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072,ko:K12257	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF
HKD1_k127_4066838_0	760011.Spico_0318	2.588e-175	556.0	COG1883@1|root,COG1883@2|Bacteria,2J77H@203691|Spirochaetes	203691|Spirochaetes	C	PFAM Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit	-	-	4.1.1.3	ko:K01572	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	OAD_beta
HKD1_k127_4069896_0	1121289.JHVL01000023_gene78	9.448e-125	408.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,36DF4@31979|Clostridiaceae	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD1_k127_4069896_1	1304284.L21TH_1312	3.167e-56	201.0	COG3869@1|root,COG3869@2|Bacteria,1TPBA@1239|Firmicutes,247SS@186801|Clostridia,36DF3@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the specific phosphorylation of arginine residues in proteins	mcsB	-	2.7.14.1	ko:K19405	-	-	R11090	RC00002,RC00203	ko00000,ko01000	-	-	-	ATP-gua_Ptrans
HKD1_k127_4073087_0	588581.Cpap_1239	3.009e-191	611.0	COG0714@1|root,COG1112@1|root,COG0714@2|Bacteria,COG1112@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia,3WHBK@541000|Ruminococcaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF2726,DUF3320,DUF4011,DUF559
HKD1_k127_4073087_3	580331.Thit_1565	2.162e-15	77.0	COG1141@1|root,COG1141@2|Bacteria,1VKVT@1239|Firmicutes,24RTU@186801|Clostridia,42H4Z@68295|Thermoanaerobacterales	186801|Clostridia	C	PFAM 4Fe-4S	fdxA	-	-	ko:K05337	-	-	-	-	ko00000	-	-	-	Fer4_13,Fer4_15
HKD1_k127_4073087_1	1280689.AUJC01000013_gene1773	4.654e-64	229.0	COG2971@1|root,COG2971@2|Bacteria,1V38W@1239|Firmicutes,25CKY@186801|Clostridia,36GN0@31979|Clostridiaceae	186801|Clostridia	G	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD1_k127_4073087_2	1174504.AJTN02000094_gene1914	2.113e-29	118.0	COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,4HNSP@91061|Bacilli,1ZJ93@1386|Bacillus	91061|Bacilli	S	Transcriptional Coactivator p15 (PC4)	XK26_06125	-	-	-	-	-	-	-	-	-	-	-	PC4
HKD1_k127_407715_1	572547.Amico_0029	8.283e-13	71.0	COG5496@1|root,COG5496@2|Bacteria,3TBE7@508458|Synergistetes	508458|Synergistetes	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_407715_0	720554.Clocl_1086	1.866e-33	140.0	28NCT@1|root,2ZBFR@2|Bacteria,1UKIC@1239|Firmicutes,249KB@186801|Clostridia,3WNDW@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4080506_3	1325130.HFN_0226	1.079e-22	97.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,42MWA@68525|delta/epsilon subdivisions,2YMQ7@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD1_k127_4080506_2	1232443.BAIA02000126_gene1108	8.261e-76	260.0	COG0704@1|root,COG0704@2|Bacteria,1URN3@1239|Firmicutes,24FTM@186801|Clostridia,268P9@186813|unclassified Clostridiales	186801|Clostridia	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD1_k127_4080506_1	1160721.RBI_I00287	1.09e-82	280.0	COG0745@1|root,COG0745@2|Bacteria,1TPWS@1239|Firmicutes,25AZ2@186801|Clostridia,3WIXK@541000|Ruminococcaceae	186801|Clostridia	K	PFAM response regulator receiver	phoP	-	-	ko:K02483,ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4080506_0	1160721.RBI_I00288	7.083e-103	355.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WGB6@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4,PAS_8,PAS_9,sCache_like
HKD1_k127_4080760_4	754252.PFREUD_09040	4.842e-09	61.0	COG4910@1|root,COG4910@2|Bacteria,2IN09@201174|Actinobacteria	201174|Actinobacteria	Q	Dehydratase small subunit	pduE	-	4.2.1.28	ko:K13920	ko00640,map00640	-	R02376	RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_SU
HKD1_k127_4080760_2	1235790.C805_03548	8.477e-85	286.0	COG4909@1|root,COG4909@2|Bacteria,1UT3J@1239|Firmicutes,24GDN@186801|Clostridia,25VQS@186806|Eubacteriaceae	186801|Clostridia	Q	Dehydratase medium subunit	pduD	-	4.2.1.28,4.2.1.30	ko:K06121,ko:K13919	ko00561,ko00640,map00561,map00640	-	R01047,R02376	RC00429,RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_MU
HKD1_k127_4080760_0	469618.FVAG_00495	6.39e-295	911.0	COG4909@1|root,COG4909@2|Bacteria,378IM@32066|Fusobacteria	32066|Fusobacteria	Q	Dehydratase large subunit	-	-	4.2.1.28,4.2.1.30	ko:K01699,ko:K06120	ko00561,ko00640,map00561,map00640	-	R01047,R02376	RC00429,RC00707	ko00000,ko00001,ko01000	-	-	-	Dehydratase_LU
HKD1_k127_4080760_1	742738.HMPREF9460_01147	3.362e-119	387.0	COG4816@1|root,COG4816@2|Bacteria,1TTAA@1239|Firmicutes,2498G@186801|Clostridia,2682W@186813|unclassified Clostridiales	186801|Clostridia	E	BMC	pduB	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_4080760_3	269796.Rru_A0905	2.79e-44	162.0	COG4577@1|root,COG4577@2|Bacteria,1RH1U@1224|Proteobacteria,2UCWZ@28211|Alphaproteobacteria,2JU4Q@204441|Rhodospirillales	204441|Rhodospirillales	CQ	BMC	-	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_4090855_1	1487921.DP68_05515	4.985e-67	234.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_4090855_0	1487921.DP68_05520	4.454e-106	354.0	COG4603@1|root,COG4603@2|Bacteria,1UNT4@1239|Firmicutes,24CQN@186801|Clostridia,36G0D@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_4090855_2	585501.HMPREF6123_1217	1.373e-08	58.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,2PQWW@265975|Oribacterium	186801|Clostridia	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_4091140_1	1211817.CCAT010000083_gene1454	1.777e-67	235.0	COG0789@1|root,COG4978@1|root,COG0789@2|Bacteria,COG4978@2|Bacteria,1V0RM@1239|Firmicutes,24C7M@186801|Clostridia,36F4B@31979|Clostridiaceae	186801|Clostridia	KT	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
HKD1_k127_4091140_0	1408422.JHYF01000009_gene2034	2.751e-69	238.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,36E3A@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_4100271_0	994573.T472_0207740	0.0	1077.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_4100271_1	536227.CcarbDRAFT_1557	2.014e-52	191.0	COG1309@1|root,COG1309@2|Bacteria,1VG3M@1239|Firmicutes,25BA9@186801|Clostridia,36IYT@31979|Clostridiaceae	186801|Clostridia	K	PFAM regulatory protein TetR	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_4,TetR_N
HKD1_k127_4100271_2	696281.Desru_2136	3.888e-14	72.0	COG0697@1|root,COG0697@2|Bacteria,1TRKE@1239|Firmicutes,24KDQ@186801|Clostridia,2643B@186807|Peptococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4101404_1	1229520.ADIAL_1574	3.971e-68	242.0	COG1876@1|root,COG1876@2|Bacteria,1V1F7@1239|Firmicutes,4HBR1@91061|Bacilli,27FNF@186828|Carnobacteriaceae	91061|Bacilli	M	D-alanyl-D-alanine carboxypeptidase	vanYB	-	3.4.17.14	ko:K07260	ko00550,ko01100,ko01502,ko02020,map00550,map01100,map01502,map02020	M00651	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko01011,ko01504	-	-	-	VanY
HKD1_k127_4101404_0	1216932.CM240_0431	3.411e-121	393.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,249KK@186801|Clostridia,36EFN@31979|Clostridiaceae	186801|Clostridia	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_4103741_0	1304866.K413DRAFT_4932	1.352e-66	234.0	COG1285@1|root,COG1285@2|Bacteria,1V409@1239|Firmicutes,249SQ@186801|Clostridia,36EYH@31979|Clostridiaceae	186801|Clostridia	S	MgtC SapB transporter	-	-	-	ko:K07507	-	-	-	-	ko00000,ko02000	9.B.20	-	-	MgtC
HKD1_k127_4103741_1	1121289.JHVL01000003_gene2183	1.015e-06	59.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD1_k127_4112434_1	469381.Dpep_0857	1.563e-127	410.0	COG5012@1|root,COG5012@2|Bacteria	2|Bacteria	T	cobalamin binding	oraE	-	5.4.3.5	ko:K17898	ko00472,map00472	-	R02461	RC00719	ko00000,ko00001,ko01000	-	-	-	B12-binding,Lys-AminoMut_A,OAM_dimer
HKD1_k127_4112434_0	469381.Dpep_0856	4.026e-153	488.0	COG0849@1|root,COG0849@2|Bacteria,3TC6B@508458|Synergistetes	508458|Synergistetes	D	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD1_k127_411672_5	903814.ELI_2848	5.1e-15	78.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,25WBA@186806|Eubacteriaceae	186801|Clostridia	EG	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_411672_2	1304284.L21TH_1638	1.121e-98	329.0	COG0503@1|root,COG0503@2|Bacteria,1TPN9@1239|Firmicutes,25CKT@186801|Clostridia,36EDN@31979|Clostridiaceae	186801|Clostridia	F	pur operon repressor	purR	-	-	ko:K09685	-	-	-	-	ko00000,ko03000	-	-	-	Pribosyltran,PuR_N
HKD1_k127_411672_4	1304284.L21TH_1639	3.801e-41	153.0	COG2088@1|root,COG2088@2|Bacteria,1V9ZG@1239|Firmicutes,24MVQ@186801|Clostridia,36JKP@31979|Clostridiaceae	186801|Clostridia	D	Could be involved in septation	spoVG	-	-	ko:K06412	-	-	-	-	ko00000	-	-	-	SpoVG
HKD1_k127_411672_1	1347392.CCEZ01000020_gene932	1.254e-176	564.0	COG1207@1|root,COG1207@2|Bacteria,1TP88@1239|Firmicutes,248Z3@186801|Clostridia,36EN8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3,NTP_transferase
HKD1_k127_411672_3	1304284.L21TH_1642	1.657e-67	234.0	COG0193@1|root,COG0193@2|Bacteria,1V3NB@1239|Firmicutes,24HMC@186801|Clostridia,36G0N@31979|Clostridiaceae	186801|Clostridia	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD1_k127_411672_0	1347392.CCEZ01000020_gene935	9.305e-210	676.0	COG1197@1|root,COG1197@2|Bacteria,1TPF1@1239|Firmicutes,248D8@186801|Clostridia,36F91@31979|Clostridiaceae	186801|Clostridia	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD1_k127_4133941_0	913865.DOT_2619	1.36e-101	334.0	COG3547@1|root,COG3547@2|Bacteria,1TQP6@1239|Firmicutes,248VD@186801|Clostridia,2612E@186807|Peptococcaceae	186801|Clostridia	L	PFAM transposase IS116 IS110 IS902 family	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD1_k127_4148831_2	1280689.AUJC01000001_gene2212	0.0003338	46.0	COG0789@1|root,COG0789@2|Bacteria,1V0RM@1239|Firmicutes,24C7M@186801|Clostridia,36F4B@31979|Clostridiaceae	186801|Clostridia	KT	helix_turn_helix, mercury resistance	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like,MerR_1
HKD1_k127_4148831_0	2754.EH55_05700	1.507e-99	331.0	COG1288@1|root,COG1288@2|Bacteria,3T9V1@508458|Synergistetes	508458|Synergistetes	S	AbgT putative transporter family	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_4148831_1	2754.EH55_05700	3.736e-32	126.0	COG1288@1|root,COG1288@2|Bacteria,3T9V1@508458|Synergistetes	508458|Synergistetes	S	AbgT putative transporter family	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_415033_0	742740.HMPREF9474_03610	6.159e-123	400.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,222BP@1506553|Lachnoclostridium	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD1_k127_4152465_1	1120746.CCNL01000014_gene2169	8.242e-41	153.0	COG0463@1|root,COG0463@2|Bacteria	2|Bacteria	M	Glycosyl transferase, family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_tranf_2_4,Glycos_transf_2
HKD1_k127_4152465_0	536227.CcarbDRAFT_0494	8.452e-108	356.0	COG2119@1|root,COG2119@2|Bacteria,1UFX2@1239|Firmicutes,24DHF@186801|Clostridia,36HDQ@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein family UPF0016	-	-	-	-	-	-	-	-	-	-	-	-	UPF0016
HKD1_k127_4172118_1	1511.CLOST_1401	1.386e-56	201.0	COG4658@1|root,COG4658@2|Bacteria,1TQAY@1239|Firmicutes,247TM@186801|Clostridia,25SDW@186804|Peptostreptococcaceae	186801|Clostridia	C	NQR2, RnfD, RnfE family	rnfD	-	-	ko:K03614	-	-	-	-	ko00000	-	-	-	NQR2_RnfD_RnfE
HKD1_k127_4172118_2	471875.RUMLAC_02287	7.151e-22	102.0	COG4659@1|root,COG4659@2|Bacteria,1V7R1@1239|Firmicutes,24JVM@186801|Clostridia	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfG	-	-	ko:K03612	-	-	-	-	ko00000	-	-	-	FMN_bind
HKD1_k127_4172118_0	340099.Teth39_2121	4.7e-76	259.0	COG4660@1|root,COG4660@2|Bacteria,1TSE7@1239|Firmicutes,24972@186801|Clostridia,42G5V@68295|Thermoanaerobacterales	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfE	-	-	ko:K03613	-	-	-	-	ko00000	-	-	iHN637.CLJU_RS05585	Rnf-Nqr
HKD1_k127_4172118_3	1307761.L21SP2_0452	9.201e-16	78.0	COG4657@1|root,COG4657@2|Bacteria,2J5ES@203691|Spirochaetes	203691|Spirochaetes	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
HKD1_k127_4172938_1	865861.AZSU01000003_gene1804	3.882e-65	233.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,36DJ0@31979|Clostridiaceae	186801|Clostridia	L	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_4172938_0	1031288.AXAA01000007_gene861	8.585e-79	266.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,36E24@31979|Clostridiaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HKD1_k127_4179349_1	509191.AEDB02000100_gene4093	4.248e-103	347.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,3WNE8@541000|Ruminococcaceae	186801|Clostridia	KT	Membrane-associated sensor domain	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	MASE3,SpoIIE
HKD1_k127_4179349_0	1280698.AUJS01000031_gene1944	3.997e-124	405.0	COG0416@1|root,COG0416@2|Bacteria,1TPY8@1239|Firmicutes,248BX@186801|Clostridia,27VF3@189330|Dorea	186801|Clostridia	I	Fatty acid synthesis protein	grdD	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K21576	-	-	-	-	ko00000,ko01000	-	-	-	FA_synthesis
HKD1_k127_4179403_2	748727.CLJU_c28730	1.815e-43	159.0	COG1082@1|root,COG1082@2|Bacteria,1TT50@1239|Firmicutes,248RM@186801|Clostridia,36F79@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_4179403_1	1121289.JHVL01000013_gene1611	5.364e-113	374.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,36FVM@31979|Clostridiaceae	186801|Clostridia	S	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD1_k127_4179403_0	1128398.Curi_c27760	6.047e-122	399.0	COG1242@1|root,COG1242@2|Bacteria,1TQ57@1239|Firmicutes,247U3@186801|Clostridia,267Q9@186813|unclassified Clostridiales	186801|Clostridia	S	Radical_SAM C-terminal domain	ytqA	-	-	ko:K07139	-	-	-	-	ko00000	-	-	-	Radical_SAM,Radical_SAM_C
HKD1_k127_4179403_3	1089548.KI783301_gene3057	2.14e-22	104.0	COG0747@1|root,COG0747@2|Bacteria	2|Bacteria	E	dipeptide transport	-	-	-	-	-	-	-	-	-	-	-	-	B_lectin,DUF1566,SLH
HKD1_k127_4200522_2	411902.CLOBOL_04038	2.065e-85	285.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,222HP@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_4200522_1	1033744.CAEL01000024_gene1694	3.384e-176	559.0	COG0044@1|root,COG0044@2|Bacteria,1TPI6@1239|Firmicutes,2495I@186801|Clostridia,22GJ2@1570339|Peptoniphilaceae	186801|Clostridia	F	Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation	iadA	-	-	ko:K01305	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_4200522_0	1304284.L21TH_2712	3.409e-181	586.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_12,HTH_8,PAS,PAS_9,Sigma54_activat
HKD1_k127_4205152_1	932677.PAJ_2235	5.773e-28	120.0	COG3829@1|root,COG3829@2|Bacteria,1NU8B@1224|Proteobacteria,1RMHY@1236|Gammaproteobacteria,3VZD5@53335|Pantoea	1236|Gammaproteobacteria	KT	Propionate catabolism activator	-	-	-	ko:K11914	-	-	-	-	ko00000,ko02044,ko03000	-	-	-	HTH_8,PrpR_N,Sigma54_activat
HKD1_k127_4205152_0	1121296.JONJ01000022_gene1523	4.206e-89	296.0	COG0684@1|root,COG0684@2|Bacteria,1V1ME@1239|Firmicutes,24E8B@186801|Clostridia,2228K@1506553|Lachnoclostridium	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD1_k127_4214793_4	1336241.JAEB01000008_gene1038	7.429e-18	87.0	COG0632@1|root,COG0632@2|Bacteria,1V3KF@1239|Firmicutes,24JKV@186801|Clostridia,25W9F@186806|Eubacteriaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD1_k127_4214793_1	1476973.JMMB01000007_gene669	4.204e-148	475.0	COG2255@1|root,COG2255@2|Bacteria,1TR47@1239|Firmicutes,247W0@186801|Clostridia,25QWA@186804|Peptostreptococcaceae	186801|Clostridia	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD1_k127_4214793_3	1121324.CLIT_5c00930	3.11e-79	285.0	COG2385@1|root,COG2385@2|Bacteria,1UW6J@1239|Firmicutes,24CYM@186801|Clostridia,25T9S@186804|Peptostreptococcaceae	186801|Clostridia	D	Stage II sporulation protein	lytB	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	PG_binding_1,SpoIID,Y_Y_Y
HKD1_k127_4214793_0	575593.HMPREF0491_01394	1.019e-151	486.0	COG0809@1|root,COG0809@2|Bacteria,1TPKD@1239|Firmicutes,247NT@186801|Clostridia,27J98@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD1_k127_4214793_2	1304284.L21TH_1271	4.594e-95	312.0	COG0343@1|root,COG0343@2|Bacteria,1TNZ4@1239|Firmicutes,247NJ@186801|Clostridia,36FEZ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD1_k127_421527_2	1304284.L21TH_0643	1.344e-38	152.0	COG2302@1|root,COG2302@2|Bacteria,1U5V2@1239|Firmicutes,24GDV@186801|Clostridia,36IWC@31979|Clostridiaceae	186801|Clostridia	S	S4 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	S4
HKD1_k127_421527_4	1347392.CCEZ01000043_gene540	1.785e-12	70.0	COG0762@1|root,COG0762@2|Bacteria	2|Bacteria	D	integral membrane protein	yggT	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD1_k127_421527_3	865861.AZSU01000003_gene1605	6.387e-26	112.0	COG1799@1|root,COG1799@2|Bacteria,1VER3@1239|Firmicutes,24I9Y@186801|Clostridia,36I3V@31979|Clostridiaceae	186801|Clostridia	D	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA	sepF	-	-	ko:K09772	-	-	-	-	ko00000,ko03036	-	-	-	SepF
HKD1_k127_421527_0	1304284.L21TH_0640	6.038e-78	267.0	COG0325@1|root,COG0325@2|Bacteria,1TRDN@1239|Firmicutes,248R6@186801|Clostridia,36DX0@31979|Clostridiaceae	186801|Clostridia	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	ylmE	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD1_k127_421527_1	1121289.JHVL01000003_gene2315	8.405e-51	194.0	COG0845@1|root,COG0845@2|Bacteria,1TRN9@1239|Firmicutes,248G2@186801|Clostridia,36INS@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_421803_3	642492.Clole_1910	3.103e-29	119.0	COG0760@1|root,COG0760@2|Bacteria,1V5Q2@1239|Firmicutes,248JQ@186801|Clostridia	186801|Clostridia	O	peptidylprolyl isomerase	prsA2	-	5.2.1.8	ko:K03769,ko:K07533	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_2,Rotamase_3
HKD1_k127_421803_4	1304284.L21TH_1097	1.425e-18	88.0	COG1925@1|root,COG1925@2|Bacteria,1VA0R@1239|Firmicutes,24QIP@186801|Clostridia,36KJQ@31979|Clostridiaceae	186801|Clostridia	G	HPr family	ptsH	-	-	ko:K11184,ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD1_k127_421803_1	1121289.JHVL01000013_gene1622	1.356e-106	355.0	COG1481@1|root,COG1481@2|Bacteria,1TP2X@1239|Firmicutes,2484M@186801|Clostridia,36EVX@31979|Clostridiaceae	186801|Clostridia	K	May be required for sporulation	whiA	-	-	ko:K09762	-	-	-	-	ko00000	-	-	-	HTH_WhiA,LAGLIDADG_WhiA,WhiA_N
HKD1_k127_421803_2	1121289.JHVL01000013_gene1623	1.048e-42	160.0	COG0494@1|root,COG0494@2|Bacteria,1UJC7@1239|Firmicutes,25F1K@186801|Clostridia,36K8D@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the Nudix hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_421803_0	1304284.L21TH_2706	4.116e-147	475.0	COG0116@1|root,COG0116@2|Bacteria,1TP0X@1239|Firmicutes,248MA@186801|Clostridia,36E5D@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the methyltransferase superfamily	ypsC	-	-	ko:K07444	-	-	-	-	ko00000,ko01000	-	-	-	THUMP,UPF0020
HKD1_k127_421803_5	388413.ALPR1_07585	9.454e-07	51.0	COG2204@1|root,COG2204@2|Bacteria,4NE89@976|Bacteroidetes,47N6B@768503|Cytophagia	976|Bacteroidetes	T	two component, sigma54 specific, transcriptional regulator, Fis family	zraR	-	-	ko:K07713	ko02020,map02020	M00499	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD1_k127_4227315_0	1499683.CCFF01000017_gene3029	5.541e-88	301.0	COG1674@1|root,COG1674@2|Bacteria,1UXRU@1239|Firmicutes,24NF9@186801|Clostridia,36KK8@31979|Clostridiaceae	186801|Clostridia	D	FtsK/SpoIIIE family	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_SpoIIIE
HKD1_k127_4230139_0	1304284.L21TH_2050	4.757e-73	255.0	COG1600@1|root,COG1600@2|Bacteria,1TP6Q@1239|Firmicutes,248M5@186801|Clostridia,36FFZ@31979|Clostridiaceae	186801|Clostridia	C	iron-sulfur cluster-binding protein	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16,HEAT_2
HKD1_k127_4230139_1	509191.AEDB02000108_gene1668	1.968e-27	113.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,3WK8N@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HKD1_k127_4230139_2	1499689.CCNN01000007_gene2105	3.795e-19	88.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,36DBQ@31979|Clostridiaceae	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_4231990_0	1121335.Clst_0947	4.196e-61	227.0	28NCT@1|root,2ZBFR@2|Bacteria,1UKIC@1239|Firmicutes,249KB@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_424075_0	515620.EUBELI_01029	3.406e-271	845.0	COG1032@1|root,COG1032@2|Bacteria,1TQ8X@1239|Firmicutes,248IW@186801|Clostridia,25VRA@186806|Eubacteriaceae	186801|Clostridia	C	UPF0313 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3362,Radical_SAM,Radical_SAM_N
HKD1_k127_424075_2	1211035.CD30_10090	6.871e-77	263.0	COG0274@1|root,COG0274@2|Bacteria,1TPAJ@1239|Firmicutes,4HAAJ@91061|Bacilli,3IX5U@400634|Lysinibacillus	91061|Bacilli	F	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate	deoC	-	4.1.2.4	ko:K01619	ko00030,map00030	-	R01066	RC00436,RC00437	ko00000,ko00001,ko01000	-	-	-	DeoC
HKD1_k127_424075_1	350688.Clos_1360	6.518e-78	265.0	COG4869@1|root,COG4869@2|Bacteria,1V242@1239|Firmicutes,24816@186801|Clostridia,36E22@31979|Clostridiaceae	186801|Clostridia	Q	Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate	pduL	-	2.3.1.8	ko:K15024	ko00430,ko00620,ko00640,ko00720,ko01100,ko01120,ko01200,map00430,map00620,map00640,map00720,map01100,map01120,map01200	M00579	R00230,R00921	RC00004,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans,PTAC
HKD1_k127_424364_2	1120998.AUFC01000002_gene2718	4.326e-47	173.0	COG1905@1|root,COG1905@2|Bacteria,1V4IR@1239|Firmicutes,24BTN@186801|Clostridia	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	-	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_424364_0	666686.B1NLA3E_11420	6.255e-278	865.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,4HFIP@91061|Bacilli,1ZD3I@1386|Bacillus	1239|Firmicutes	C	COG2414 Aldehyde ferredoxin oxidoreductase	aor	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS09915	AFOR_C,AFOR_N
HKD1_k127_424364_1	411468.CLOSCI_03468	2.034e-53	192.0	COG1142@1|root,COG1142@2|Bacteria,1V6Y9@1239|Firmicutes,24HFG@186801|Clostridia,220A0@1506553|Lachnoclostridium	186801|Clostridia	C	Psort location Cytoplasmic, score 9.98	-	-	-	ko:K05796	-	-	-	-	ko00000	-	-	-	Fer4_11,Fer4_4,Fer4_6
HKD1_k127_424364_4	871968.DESME_01155	2.869e-14	74.0	COG1977@1|root,COG1977@2|Bacteria,1VIST@1239|Firmicutes,24QYP@186801|Clostridia	186801|Clostridia	H	ThiS family	moaD	-	-	-	-	-	-	-	-	-	-	-	ThiS
HKD1_k127_424364_3	1120998.AUFC01000023_gene2189	1.363e-33	130.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,24HED@186801|Clostridia,3WDB0@538999|Clostridiales incertae sedis	186801|Clostridia	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD1_k127_4248947_1	1449050.JNLE01000003_gene1723	1.232e-90	304.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,36W7H@31979|Clostridiaceae	186801|Clostridia	G	hydrolase, family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD1_k127_4248947_0	1347392.CCEZ01000049_gene1608	4.455e-236	745.0	COG0322@1|root,COG0322@2|Bacteria,1TP4B@1239|Firmicutes,247TQ@186801|Clostridia,36DMH@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_2,HHH_5,UVR,UvrC_HhH_N
HKD1_k127_4248947_2	272563.CD630_34090	2.022e-37	145.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,25QP9@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD1_k127_4250465_0	1304284.L21TH_1549	2.443e-201	635.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,36DQ1@31979|Clostridiaceae	186801|Clostridia	K	domain protein	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD1_k127_4263750_1	702450.CUW_1471	2.88e-78	264.0	COG1521@1|root,COG1521@2|Bacteria,1TR0X@1239|Firmicutes,3VP1V@526524|Erysipelotrichia	526524|Erysipelotrichia	H	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD1_k127_4263750_0	1304284.L21TH_2221	3.151e-92	308.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,36E0M@31979|Clostridiaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_4264791_1	1230342.CTM_04758	4.627e-148	478.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	-	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4264791_2	632245.CLP_1434	3.382e-10	61.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4264791_0	742741.HMPREF9475_00641	3.796e-154	499.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,2205F@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_4274354_2	1121289.JHVL01000031_gene370	1.899e-103	340.0	COG0152@1|root,COG0152@2|Bacteria,1TP11@1239|Firmicutes,2483I@186801|Clostridia,36E2A@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the SAICAR synthetase family	purC	-	4.3.2.2,6.3.2.6	ko:K01756,ko:K01923	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559,R04591	RC00064,RC00162,RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD1_k127_4274354_0	1304284.L21TH_1810	1.377e-211	665.0	COG0034@1|root,COG0034@2|Bacteria,1TPH3@1239|Firmicutes,247RF@186801|Clostridia,36ECS@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_6,GATase_7,Pribosyltran
HKD1_k127_4274354_1	1304284.L21TH_1809	1.542e-118	384.0	COG0150@1|root,COG0150@2|Bacteria,1TP9J@1239|Firmicutes,248BT@186801|Clostridia,36F1W@31979|Clostridiaceae	186801|Clostridia	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD1_k127_4274719_8	1487921.DP68_04480	3.385e-57	201.0	COG0764@1|root,COG0764@2|Bacteria,1V6EX@1239|Firmicutes,24JAW@186801|Clostridia,36IPJ@31979|Clostridiaceae	186801|Clostridia	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD1_k127_4274719_1	857293.CAAU_1536	1.304e-173	553.0	COG0304@1|root,COG0304@2|Bacteria,1TPA7@1239|Firmicutes,247VF@186801|Clostridia,36E5Q@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD1_k127_4274719_6	1304284.L21TH_1399	3.075e-85	288.0	COG1028@1|root,COG1028@2|Bacteria,1TP76@1239|Firmicutes,247PV@186801|Clostridia,36EGR@31979|Clostridiaceae	186801|Clostridia	IQ	reductase	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_4274719_5	2325.TKV_c13890	5.149e-99	332.0	COG0331@1|root,COG0331@2|Bacteria,1TPB7@1239|Firmicutes,247UF@186801|Clostridia,42EZH@68295|Thermoanaerobacterales	186801|Clostridia	I	malonyl coa-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD1_k127_4274719_3	999411.HMPREF1092_00847	8.194e-125	407.0	COG2070@1|root,COG2070@2|Bacteria,1TPC3@1239|Firmicutes,24831@186801|Clostridia,36E25@31979|Clostridiaceae	186801|Clostridia	S	2-nitropropane dioxygenase	fabK	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	iHN637.CLJU_RS20775	NMO
HKD1_k127_4274719_11	1089548.KI783301_gene2139	1.822e-15	78.0	COG0236@1|root,COG0236@2|Bacteria,1VEE3@1239|Firmicutes,4HNQ0@91061|Bacilli,3WF0V@539002|Bacillales incertae sedis	91061|Bacilli	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	GO:0000035,GO:0000036,GO:0003674,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005975,GO:0006082,GO:0006629,GO:0006631,GO:0006633,GO:0006643,GO:0006644,GO:0006664,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0008610,GO:0008654,GO:0009058,GO:0009245,GO:0009247,GO:0009311,GO:0009312,GO:0009987,GO:0016051,GO:0016053,GO:0019637,GO:0019752,GO:0019842,GO:0031177,GO:0032787,GO:0033218,GO:0036094,GO:0043167,GO:0043168,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044255,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0044620,GO:0046394,GO:0046467,GO:0046493,GO:0048037,GO:0051192,GO:0071704,GO:0072330,GO:0072341,GO:0090407,GO:0140104,GO:1901135,GO:1901137,GO:1901269,GO:1901271,GO:1901576,GO:1903509	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD1_k127_4274719_0	1121289.JHVL01000001_gene1828	4.527e-182	576.0	COG0381@1|root,COG0381@2|Bacteria,1TQZT@1239|Firmicutes,247N7@186801|Clostridia,36EW4@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-N-acetylglucosamine 2-epimerase family	-	-	5.1.3.14	ko:K01791	ko00520,ko01100,ko05111,map00520,map01100,map05111	M00362	R00420	RC00290	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	Epimerase_2
HKD1_k127_4274719_4	1304284.L21TH_0146	1.226e-117	387.0	COG0472@1|root,COG0472@2|Bacteria,1TP9V@1239|Firmicutes,247M7@186801|Clostridia,36F6R@31979|Clostridiaceae	186801|Clostridia	M	PFAM Glycosyl transferase family 4	tagO	-	2.7.8.33,2.7.8.35	ko:K02851	-	-	R08856	RC00002	ko00000,ko01000,ko01003,ko01005	-	-	-	Glycos_transf_4
HKD1_k127_4274719_9	123214.PERMA_1103	1.895e-56	200.0	COG0698@1|root,COG0698@2|Bacteria,2G43P@200783|Aquificae	200783|Aquificae	G	ribose 5-phosphate isomerase B	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD1_k127_4274719_10	857293.CAAU_0360	8.493e-33	133.0	COG0394@1|root,COG0394@2|Bacteria,1VA05@1239|Firmicutes,25CRM@186801|Clostridia,36JRD@31979|Clostridiaceae	186801|Clostridia	T	Low molecular weight phosphotyrosine protein phosphatase	ywlE	-	3.1.3.48,3.9.1.2	ko:K01104,ko:K20201	-	-	-	-	ko00000,ko01000	-	-	-	LMWPc
HKD1_k127_4274719_2	1304284.L21TH_0150	6.585e-132	430.0	COG0009@1|root,COG0009@2|Bacteria,1TP1I@1239|Firmicutes,248HS@186801|Clostridia,36EVH@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	sua	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD1_k127_4274719_7	1304284.L21TH_0151	6.951e-62	221.0	COG0428@1|root,COG0428@2|Bacteria,1TP7J@1239|Firmicutes,247Q2@186801|Clostridia,36FEF@31979|Clostridiaceae	186801|Clostridia	P	Zinc transporter	-	-	-	ko:K07238	-	-	-	-	ko00000,ko02000	2.A.5.5	-	-	Zip
HKD1_k127_4274719_13	574087.Acear_0884	3.016e-10	63.0	29XTQ@1|root,30JJS@2|Bacteria,1U4VZ@1239|Firmicutes,25NV9@186801|Clostridia,3WC7K@53433|Halanaerobiales	186801|Clostridia	S	Protein of unknown function (DUF3343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3343
HKD1_k127_4274719_12	203119.Cthe_2451	1.167e-11	72.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,248ZJ@186801|Clostridia,3WGFC@541000|Ruminococcaceae	186801|Clostridia	KL	SNF2 family	-	-	2.7.11.1	ko:K08282	-	-	-	-	ko00000,ko01000	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD1_k127_4287431_3	1392493.JIAB01000001_gene2484	1.065e-05	52.0	COG1390@1|root,COG1390@2|Bacteria,1VDHZ@1239|Firmicutes,24H5N@186801|Clostridia,27N30@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpE	-	-	ko:K02121	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_E
HKD1_k127_4287431_1	500633.CLOHIR_00879	3.562e-106	354.0	COG1527@1|root,COG1527@2|Bacteria,1U6WZ@1239|Firmicutes,249XD@186801|Clostridia,25TQB@186804|Peptostreptococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	ntpC	-	-	ko:K02119	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	vATP-synt_AC39
HKD1_k127_4287431_2	742738.HMPREF9460_03319	1.501e-30	123.0	COG1436@1|root,COG1436@2|Bacteria,1VAX7@1239|Firmicutes,24MXC@186801|Clostridia,269F0@186813|unclassified Clostridiales	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpF	-	-	ko:K02122	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_F
HKD1_k127_4287431_0	500633.CLOHIR_00881	4.08e-291	899.0	COG1155@1|root,COG1155@2|Bacteria,1TPGS@1239|Firmicutes,24882@186801|Clostridia,25QTT@186804|Peptostreptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit	atpA	-	3.6.3.14,3.6.3.15	ko:K02117	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002,ko01000	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N,ATP-synt_ab_Xtn
HKD1_k127_4293472_0	1392487.JIAD01000001_gene173	1.784e-58	211.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,25WK6@186806|Eubacteriaceae	186801|Clostridia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4293472_1	552398.HMPREF0866_03037	3.825e-39	147.0	COG1834@1|root,COG1834@2|Bacteria,1VDT8@1239|Firmicutes,25EE3@186801|Clostridia,3WR2S@541000|Ruminococcaceae	186801|Clostridia	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD1_k127_4295343_1	865861.AZSU01000003_gene1935	8.281e-13	70.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,36GGB@31979|Clostridiaceae	186801|Clostridia	S	Division initiation protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
HKD1_k127_4295343_2	1408422.JHYF01000002_gene2530	6.828e-11	67.0	COG3856@1|root,COG3856@2|Bacteria,1VA6N@1239|Firmicutes,24N58@186801|Clostridia,36JGG@31979|Clostridiaceae	186801|Clostridia	S	small basic protein	sbp	-	-	-	-	-	-	-	-	-	-	-	DUF1290
HKD1_k127_4295343_0	1304284.L21TH_0622	7.054e-141	454.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,36F0J@31979|Clostridiaceae	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_4296391_2	1128398.Curi_c16790	2.782e-13	72.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,26800@186813|unclassified Clostridiales	186801|Clostridia	T	Serine/threonine phosphatases, family 2C, catalytic domain	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD1_k127_4296391_0	386415.NT01CX_2241	4.735e-121	397.0	COG0820@1|root,COG0820@2|Bacteria,1TPVF@1239|Firmicutes,248BC@186801|Clostridia,36E1B@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Fer4_14,Radical_SAM
HKD1_k127_4296391_1	1347392.CCEZ01000043_gene521	4.562e-49	178.0	COG0144@1|root,COG0781@1|root,COG0144@2|Bacteria,COG0781@2|Bacteria,1TP3N@1239|Firmicutes,248CS@186801|Clostridia,36DEN@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA	sun	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,Methyltr_RsmF_N,NusB
HKD1_k127_4296411_1	511051.CSE_14130	3.451e-100	339.0	COG1744@1|root,COG1744@2|Bacteria	2|Bacteria	ET	ABC transporter substrate-binding protein PnrA-like	-	-	-	ko:K02058,ko:K07335	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	Bmp
HKD1_k127_4296411_0	1487921.DP68_05545	3.346e-157	507.0	COG1397@1|root,COG1397@2|Bacteria,1TSKF@1239|Firmicutes,25DA4@186801|Clostridia,36VE3@31979|Clostridiaceae	186801|Clostridia	O	ADP-ribosylglycohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	ADP_ribosyl_GH
HKD1_k127_4300347_0	536227.CcarbDRAFT_1892	2.106e-180	573.0	COG5016@1|root,COG5016@2|Bacteria,1VT8P@1239|Firmicutes,247NZ@186801|Clostridia,36UI3@31979|Clostridiaceae	186801|Clostridia	C	carboxyltransferase	pycB	-	4.1.1.3	ko:K01571	ko00620,ko01100,map00620,map01100	-	R00217	RC00040	ko00000,ko00001,ko01000,ko02000	3.B.1.1.1	-	-	HMGL-like,PYC_OADA
HKD1_k127_4300347_1	1304284.L21TH_1293	5.036e-101	334.0	COG0217@1|root,COG0217@2|Bacteria,1TPP5@1239|Firmicutes,247NK@186801|Clostridia,36E08@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulatory protein	yebC	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD1_k127_4300347_3	1128398.Curi_c10390	5.988e-79	268.0	COG1739@1|root,COG1739@2|Bacteria,1V6MQ@1239|Firmicutes,248W7@186801|Clostridia,269GI@186813|unclassified Clostridiales	186801|Clostridia	S	Uncharacterized protein family UPF0029	yvyE	-	-	-	-	-	-	-	-	-	-	-	DUF1949,UPF0029
HKD1_k127_4300347_2	1304284.L21TH_1303	2.31e-80	277.0	COG2262@1|root,COG2262@2|Bacteria,1TNZB@1239|Firmicutes,248IU@186801|Clostridia,36DCE@31979|Clostridiaceae	186801|Clostridia	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD1_k127_4306835_2	1511.CLOST_0888	7.069e-66	232.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding	moeB	-	-	-	-	-	-	-	-	-	-	-	ThiF
HKD1_k127_4306835_1	865861.AZSU01000003_gene1772	4.532e-111	367.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,36HBU@31979|Clostridiaceae	186801|Clostridia	G	peptidase M42 family protein	celM	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
HKD1_k127_4306835_0	1347392.CCEZ01000043_gene424	3.753e-114	377.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,248D0@186801|Clostridia,36F05@31979|Clostridiaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	3.2.1.4	ko:K01179	ko00500,ko01100,map00500,map01100	-	R06200,R11307,R11308	-	ko00000,ko00001,ko01000	-	GH5,GH9	-	Peptidase_M42
HKD1_k127_4306835_3	720554.Clocl_1681	2.434e-32	130.0	COG1363@1|root,COG1363@2|Bacteria,1TNZT@1239|Firmicutes,24BAN@186801|Clostridia,3WG8E@541000|Ruminococcaceae	186801|Clostridia	G	M42 glutamyl aminopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M42
HKD1_k127_4307398_2	500633.CLOHIR_00270	3.386e-10	60.0	COG1307@1|root,COG1307@2|Bacteria,1UZ7P@1239|Firmicutes,25BCK@186801|Clostridia	186801|Clostridia	S	EDD domain protein, DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_4307398_1	443254.Marpi_1646	1.324e-12	77.0	COG0368@1|root,COG0368@2|Bacteria	2|Bacteria	H	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate	cobS	GO:0003674,GO:0003824,GO:0006725,GO:0006766,GO:0006767,GO:0006807,GO:0008150,GO:0008152,GO:0008818,GO:0009058,GO:0009110,GO:0009235,GO:0009236,GO:0009987,GO:0016740,GO:0016772,GO:0016780,GO:0017144,GO:0018130,GO:0019438,GO:0033013,GO:0033014,GO:0034641,GO:0042364,GO:0044237,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0046483,GO:0051186,GO:0051188,GO:0071704,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576	2.7.8.26	ko:K02233	ko00860,ko01100,map00860,map01100	M00122	R05223,R11174	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CobS
HKD1_k127_4307398_0	714313.LSA_00190	1.22e-12	69.0	COG1576@1|root,COG1576@2|Bacteria,1V3JM@1239|Firmicutes,4HFP8@91061|Bacilli,3F3YX@33958|Lactobacillaceae	91061|Bacilli	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD1_k127_4314422_2	1294142.CINTURNW_3234	2.066e-17	82.0	COG0245@1|root,COG0245@2|Bacteria,1V3P0@1239|Firmicutes,24HCM@186801|Clostridia,36HZE@31979|Clostridiaceae	186801|Clostridia	I	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP)	ispF	-	2.7.7.60,4.6.1.12	ko:K01770,ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD1_k127_4314422_0	1321778.HMPREF1982_00544	5.298e-55	200.0	COG1211@1|root,COG1211@2|Bacteria,1V3M7@1239|Firmicutes,248E6@186801|Clostridia,269H3@186813|unclassified Clostridiales	186801|Clostridia	I	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP)	ispD	-	2.7.7.60	ko:K00991	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS20335	IspD
HKD1_k127_4314422_1	445971.ANASTE_01914	5.083e-30	122.0	COG0613@1|root,COG0613@2|Bacteria,1V3Z7@1239|Firmicutes,24KHP@186801|Clostridia	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
HKD1_k127_4318028_0	293826.Amet_2925	7.649e-100	336.0	COG2202@1|root,COG5001@1|root,COG2202@2|Bacteria,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS,PAS_3,PAS_9
HKD1_k127_4320043_0	1347392.CCEZ01000008_gene2158	5.412e-129	415.0	COG0708@1|root,COG0708@2|Bacteria,1TPFB@1239|Firmicutes,24849@186801|Clostridia,36E73@31979|Clostridiaceae	186801|Clostridia	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD1_k127_4323830_3	1121324.CLIT_11c00220	2.118e-50	182.0	COG0591@1|root,COG0591@2|Bacteria,1TQEZ@1239|Firmicutes,24AJN@186801|Clostridia,25T2R@186804|Peptostreptococcaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	-	-	-	ko:K03307	-	-	-	-	ko00000	2.A.21	-	-	SSF
HKD1_k127_4323830_1	913865.DOT_3733	6.91e-69	239.0	COG0398@1|root,COG0398@2|Bacteria	2|Bacteria	M	Pfam SNARE associated Golgi protein	-	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_4323830_0	756499.Desde_0741	2.641e-112	370.0	COG0508@1|root,COG0508@2|Bacteria,1V9QA@1239|Firmicutes,24KV2@186801|Clostridia,265UJ@186807|Peptococcaceae	186801|Clostridia	C	dehydrogenase complex catalyzes the overall conversion of	-	-	-	-	-	-	-	-	-	-	-	-	2-oxoacid_dh
HKD1_k127_4323830_2	1469948.JPNB01000002_gene3804	6.178e-62	215.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
HKD1_k127_4324735_0	868595.Desca_1921	3.711e-102	336.0	COG1122@1|root,COG1122@2|Bacteria,1TSSM@1239|Firmicutes,249KS@186801|Clostridia,2602Q@186807|Peptococcaceae	186801|Clostridia	P	ABC-type cobalt transport system ATPase component	cbiO	-	-	ko:K02006	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	ABC_tran
HKD1_k127_4324735_1	994573.T472_0209315	2.444e-100	331.0	COG1606@1|root,COG1606@2|Bacteria,1TPB2@1239|Firmicutes,2485J@186801|Clostridia,36DE3@31979|Clostridiaceae	186801|Clostridia	S	TIGRFAM TIGR00268 family protein	-	-	-	ko:K06864	-	-	-	-	ko00000	-	-	-	ATP_bind_3,Asn_synthase,NAD_synthase,QueC
HKD1_k127_4327829_0	720554.Clocl_2786	4.371e-89	306.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WI09@541000|Ruminococcaceae	186801|Clostridia	L	exonuclease	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
HKD1_k127_4328848_0	903814.ELI_3049	3.507e-74	260.0	COG0697@1|root,COG0697@2|Bacteria,1V05H@1239|Firmicutes,24C92@186801|Clostridia	186801|Clostridia	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4328848_1	1031288.AXAA01000017_gene192	3.992e-53	192.0	COG3012@1|root,COG3012@2|Bacteria,1V1CC@1239|Firmicutes,24FYC@186801|Clostridia,36I0Z@31979|Clostridiaceae	186801|Clostridia	U	PFAM SEC-C motif	secA_2	-	-	-	-	-	-	-	-	-	-	-	SEC-C
HKD1_k127_4329379_1	1487921.DP68_01360	1.127e-42	157.0	COG1670@1|root,COG1670@2|Bacteria,1V78E@1239|Firmicutes,24KWJ@186801|Clostridia	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_4329379_3	1321778.HMPREF1982_00646	1.908e-15	78.0	COG1670@1|root,COG1670@2|Bacteria,1V78E@1239|Firmicutes,24KWJ@186801|Clostridia	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_4329379_2	1196322.A370_01245	1.212e-42	156.0	2C860@1|root,32YBD@2|Bacteria,1VFMG@1239|Firmicutes,24KVN@186801|Clostridia,36K7R@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4329379_0	1262449.CP6013_0547	2.149e-56	199.0	COG0477@1|root,COG2814@2|Bacteria,1TRUT@1239|Firmicutes,25E84@186801|Clostridia	186801|Clostridia	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD1_k127_4332596_1	742723.HMPREF9477_02002	1.228e-71	247.0	COG2267@1|root,COG2267@2|Bacteria,1TRM1@1239|Firmicutes,247J5@186801|Clostridia,27J3P@186928|unclassified Lachnospiraceae	186801|Clostridia	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_4
HKD1_k127_4332596_2	272563.CD630_15760	5.494e-65	227.0	COG2755@1|root,COG2755@2|Bacteria,1VDE2@1239|Firmicutes,24N6X@186801|Clostridia,25U6A@186804|Peptostreptococcaceae	186801|Clostridia	E	GDSL-like Lipase/Acylhydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Lipase_GDSL_2
HKD1_k127_4332596_0	350688.Clos_0860	3.081e-119	396.0	COG0642@1|root,COG2205@2|Bacteria,1TQHB@1239|Firmicutes,247S4@186801|Clostridia,36DXC@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,KdpD,Usp
HKD1_k127_4334266_1	1196029.ALIM01000049_gene4744	1.313e-46	173.0	COG0697@1|root,COG0697@2|Bacteria,1V3QH@1239|Firmicutes,4HDBZ@91061|Bacilli,1ZCM6@1386|Bacillus	91061|Bacilli	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_4334266_0	1294142.CINTURNW_2456	1.763e-86	289.0	COG1113@1|root,COG1113@2|Bacteria,1TP97@1239|Firmicutes,24AAM@186801|Clostridia,36E0P@31979|Clostridiaceae	186801|Clostridia	E	PFAM Amino acid	gabP	-	-	ko:K03293	-	-	-	-	ko00000	2.A.3.1	-	-	AA_permease
HKD1_k127_433732_1	1280664.AUIX01000023_gene915	0.0004827	44.0	2E7BG@1|root,331UU@2|Bacteria,1VHBB@1239|Firmicutes,24QNN@186801|Clostridia,4C03Y@830|Butyrivibrio	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF3021
HKD1_k127_433732_0	397288.C806_03056	2.297e-174	549.0	COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,27K75@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Acetyl-CoA hydrolase/transferase C-terminal domain	cat	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_4341937_0	552398.HMPREF0866_02539	1.355e-102	341.0	COG1472@1|root,COG1472@2|Bacteria,1TP63@1239|Firmicutes,24YIP@186801|Clostridia,3WG7U@541000|Ruminococcaceae	186801|Clostridia	G	Hydrolase Family 3	-	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD1_k127_4344876_4	1230342.CTM_22307	4.471e-11	68.0	COG0738@1|root,COG0738@2|Bacteria,1TPB5@1239|Firmicutes,24913@186801|Clostridia,36GA9@31979|Clostridiaceae	186801|Clostridia	G	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4344876_2	536227.CcarbDRAFT_2325	6.121e-66	229.0	COG1670@1|root,COG1670@2|Bacteria,1V1ZC@1239|Firmicutes,249K2@186801|Clostridia,36ESI@31979|Clostridiaceae	186801|Clostridia	J	acetyltransferase	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_4344876_1	1540257.JQMW01000011_gene1831	1.414e-109	361.0	COG0190@1|root,COG0190@2|Bacteria,1TP1P@1239|Firmicutes,248DB@186801|Clostridia,36FBW@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD1_k127_4344876_0	1121289.JHVL01000005_gene1029	1.236e-134	436.0	COG2008@1|root,COG2008@2|Bacteria,1TPZI@1239|Firmicutes	1239|Firmicutes	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_4344876_3	1230342.CTM_11485	5.416e-57	207.0	COG2186@1|root,COG2186@2|Bacteria,1V2TU@1239|Firmicutes,24AIB@186801|Clostridia,36HDT@31979|Clostridiaceae	186801|Clostridia	K	FCD domain	-	-	-	ko:K05799	-	-	-	-	ko00000,ko03000	-	-	-	FCD,GntR
HKD1_k127_4350752_1	1121334.KB911066_gene532	8.346e-111	367.0	COG1388@1|root,COG3858@1|root,COG1388@2|Bacteria,COG3858@2|Bacteria,1TQK2@1239|Firmicutes,247YF@186801|Clostridia,3WI9U@541000|Ruminococcaceae	186801|Clostridia	M	Glycosyl hydrolases family 18	-	-	-	ko:K06306	-	-	-	-	ko00000	-	-	-	Glyco_hydro_18,LysM
HKD1_k127_4350752_0	1235799.C818_03543	1.423e-111	372.0	COG0436@1|root,COG0436@2|Bacteria,1TQPD@1239|Firmicutes,24DQG@186801|Clostridia	186801|Clostridia	E	PFAM aminotransferase, class I	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD1_k127_4351040_1	521045.Kole_0965	2.644e-20	90.0	COG3246@1|root,COG3246@2|Bacteria,2GCBA@200918|Thermotogae	200918|Thermotogae	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
HKD1_k127_4351040_0	658659.HMPREF0983_03419	1.209e-126	414.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,3VPYC@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_4360008_0	1304284.L21TH_2507	1.325e-92	314.0	COG0726@1|root,COG0726@2|Bacteria,1TRUR@1239|Firmicutes,24D1N@186801|Clostridia,36H4R@31979|Clostridiaceae	186801|Clostridia	G	PFAM Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_4360008_1	1304284.L21TH_2505	1.207e-46	173.0	COG3432@1|root,COG3432@2|Bacteria,1V75P@1239|Firmicutes,24JAZ@186801|Clostridia,36IRW@31979|Clostridiaceae	186801|Clostridia	K	Domain of unknown function (DUF4364)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4364
HKD1_k127_4360008_2	192952.MM_2470	5.991e-07	61.0	COG1520@1|root,COG3291@1|root,COG3391@1|root,arCOG02516@1|root,arCOG02550@1|root,arCOG02482@2157|Archaea,arCOG02508@2157|Archaea,arCOG02516@2157|Archaea,arCOG02550@2157|Archaea,arCOG02562@2157|Archaea	2157|Archaea	Q	40-residue YVTN family beta-propeller	-	-	-	-	-	-	-	-	-	-	-	-	Lactonase,NosD,PKD,PQQ_2,PQQ_3,Pkinase
HKD1_k127_4370896_1	1304284.L21TH_1762	1.018e-34	147.0	COG4863@1|root,COG4863@2|Bacteria,1V68T@1239|Firmicutes,24HB0@186801|Clostridia,36JEP@31979|Clostridiaceae	186801|Clostridia	S	YycH protein	-	-	-	-	-	-	-	-	-	-	-	-	YycH
HKD1_k127_4370896_0	203119.Cthe_2332	2.782e-108	364.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,3WH63@541000|Ruminococcaceae	186801|Clostridia	T	Histidine kinase	yycG	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
HKD1_k127_4371451_4	1120746.CCNL01000014_gene2143	7.301e-25	104.0	COG0715@1|root,COG0715@2|Bacteria,2NRCU@2323|unclassified Bacteria	2|Bacteria	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD1_k127_4371451_2	1120746.CCNL01000014_gene2142	2.549e-90	303.0	COG1116@1|root,COG1116@2|Bacteria	2|Bacteria	P	anion transmembrane transporter activity	tauB	-	-	ko:K02049,ko:K15558	ko02010,map02010	M00188,M00437	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.5	-	-	ABC_tran
HKD1_k127_4371451_1	1120746.CCNL01000014_gene2141	3.455e-96	321.0	COG0600@1|root,COG0600@2|Bacteria,2NR8N@2323|unclassified Bacteria	2|Bacteria	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_4371451_0	86416.Clopa_1136	8.06e-129	418.0	2BZ6P@1|root,2Z8AB@2|Bacteria,1TRT3@1239|Firmicutes,247PA@186801|Clostridia,36EGY@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF2935)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2935
HKD1_k127_4371451_3	457396.CSBG_00939	6.362e-58	203.0	COG2268@1|root,COG2268@2|Bacteria,1TQDT@1239|Firmicutes,247MK@186801|Clostridia,36DN3@31979|Clostridiaceae	186801|Clostridia	S	Band 7 protein	-	-	-	ko:K07192	ko04910,map04910	-	-	-	ko00000,ko00001,ko03036,ko04131,ko04147	-	-	-	Band_7,Flot
HKD1_k127_4376562_3	536232.CLM_1998	1.75e-58	207.0	COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,36EWC@31979|Clostridiaceae	186801|Clostridia	C	Hydrogenase (NiFe) small subunit HydA	hupS	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD1_k127_4376562_5	536232.CLM_1995	8.562e-32	130.0	COG4892@1|root,COG4892@2|Bacteria,1VEGK@1239|Firmicutes,24QJ4@186801|Clostridia,36MKT@31979|Clostridiaceae	186801|Clostridia	G	PFAM cytochrome	-	-	-	-	-	-	-	-	-	-	-	-	Cyt-b5
HKD1_k127_4376562_1	1487921.DP68_15710	1.485e-65	225.0	arCOG12631@1|root,3172B@2|Bacteria,1V77G@1239|Firmicutes,24KJW@186801|Clostridia,36JIR@31979|Clostridiaceae	186801|Clostridia	S	Bacterial PH domain	-	-	-	-	-	-	-	-	-	-	-	-	bPH_1
HKD1_k127_4376562_2	1286171.EAL2_c07850	8.85e-65	229.0	arCOG03165@1|root,30AIC@2|Bacteria,1V7NB@1239|Firmicutes,24M5X@186801|Clostridia,25YS2@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4376562_4	649747.HMPREF0083_01117	2.777e-32	126.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,26YYK@186822|Paenibacillaceae	91061|Bacilli	K	Cold-shock protein	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_4376562_0	1120998.AUFC01000002_gene2857	1.191e-88	300.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1TQI2@1239|Firmicutes,24BRW@186801|Clostridia	186801|Clostridia	I	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	mprF	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HKD1_k127_4379012_1	1304880.JAGB01000001_gene605	5.784e-244	764.0	COG1236@1|root,COG1236@2|Bacteria,1TQBH@1239|Firmicutes,248QR@186801|Clostridia	186801|Clostridia	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,Lactamase_B_6,RMMBL
HKD1_k127_4379012_0	1304284.L21TH_1814	0.0	1667.0	COG0046@1|root,COG0047@1|root,COG0046@2|Bacteria,COG0047@2|Bacteria,1TPAS@1239|Firmicutes,247W2@186801|Clostridia,36UJE@31979|Clostridiaceae	186801|Clostridia	F	phosphoribosylformylglycinamidine synthase	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C,GATase_5
HKD1_k127_4379012_2	865861.AZSU01000002_gene3142	5.987e-61	214.0	COG0041@1|root,COG0041@2|Bacteria,1V1MV@1239|Firmicutes,24HCB@186801|Clostridia,36WW8@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD1_k127_4408010_2	742740.HMPREF9474_00698	4.671e-16	80.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,220WS@1506553|Lachnoclostridium	186801|Clostridia	K	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_4408010_0	1121091.AUMP01000005_gene1752	3.272e-164	531.0	COG2986@1|root,COG2986@2|Bacteria,1TQ8I@1239|Firmicutes	1239|Firmicutes	E	Aromatic amino acid lyase	-	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_4408010_1	1301100.HG529274_gene1756	6.016e-143	460.0	COG2986@1|root,COG2986@2|Bacteria,1TQ8I@1239|Firmicutes,24E1T@186801|Clostridia,36HT8@31979|Clostridiaceae	186801|Clostridia	E	Aromatic amino acid lyase	-	-	-	-	-	-	-	-	-	-	-	-	Lyase_aromatic
HKD1_k127_4416772_0	1128398.Curi_c19090	1.463e-131	429.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,268GR@186813|unclassified Clostridiales	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_4419549_0	1487921.DP68_16365	5.134e-166	528.0	COG1113@1|root,COG1113@2|Bacteria,1TP97@1239|Firmicutes,24AAM@186801|Clostridia,36E0P@31979|Clostridiaceae	186801|Clostridia	E	PFAM Amino acid	gabP	-	-	ko:K03293	-	-	-	-	ko00000	2.A.3.1	-	-	AA_permease
HKD1_k127_4419549_1	86416.Clopa_0216	2.033e-54	196.0	COG1247@1|root,COG1247@2|Bacteria,1V6X5@1239|Firmicutes,24IB5@186801|Clostridia,36JUD@31979|Clostridiaceae	186801|Clostridia	M	Acetyltransferase GNAT family	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD1_k127_4421888_3	1123009.AUID01000015_gene2039	1.466e-10	67.0	2EH7T@1|root,33AZN@2|Bacteria,1VMN0@1239|Firmicutes,24WRH@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4421888_0	1304284.L21TH_1842	9.695e-72	249.0	COG1191@1|root,COG1191@2|Bacteria,1TPJ5@1239|Firmicutes,247XH@186801|Clostridia,36EDZ@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	sigK	-	-	ko:K03091	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4
HKD1_k127_4421888_1	903814.ELI_1706	4.773e-70	246.0	COG1387@1|root,COG1387@2|Bacteria,1TQQX@1239|Firmicutes,247MM@186801|Clostridia,25WAV@186806|Eubacteriaceae	186801|Clostridia	E	PHP domain	hisK	-	3.1.3.15	ko:K04486	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R03013	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PHP
HKD1_k127_4421888_2	869213.JCM21142_42031	9.748e-38	142.0	COG2158@1|root,COG2158@2|Bacteria	2|Bacteria	S	Cysteine-rich small domain	cbiA	-	-	ko:K07162	-	-	-	-	ko00000	-	-	-	zf-like
HKD1_k127_4421888_4	858215.Thexy_0795	9.607e-06	47.0	COG2893@1|root,COG2893@2|Bacteria,1VB4C@1239|Firmicutes,24MTQ@186801|Clostridia,42IGE@68295|Thermoanaerobacterales	186801|Clostridia	G	system, fructose subfamily IIA component	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
HKD1_k127_4422660_0	350688.Clos_1334	4.575e-218	683.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,248DZ@186801|Clostridia,36EVZ@31979|Clostridiaceae	186801|Clostridia	T	carbon starvation protein CstA	cstA	-	-	-	-	-	-	-	-	-	-	-	CstA,CstA_5TM
HKD1_k127_4422660_1	1487921.DP68_10810	9.128e-29	119.0	COG1502@1|root,COG1502@2|Bacteria,1TPKY@1239|Firmicutes,247UR@186801|Clostridia,36EA0@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD1_k127_4423412_3	697303.Thewi_0386	1.495e-54	196.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,42F5G@68295|Thermoanaerobacterales	186801|Clostridia	H	MoeA domain protein domain I and II	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD1_k127_4423412_2	748727.CLJU_c25060	6.855e-72	245.0	COG0521@1|root,COG0521@2|Bacteria,1V3XM@1239|Firmicutes,24HG2@186801|Clostridia,36J7G@31979|Clostridiaceae	186801|Clostridia	H	molybdenum cofactor	mog	-	-	-	-	-	-	-	-	-	-	-	MOSC,MoCF_biosynth
HKD1_k127_4423412_1	1540257.JQMW01000010_gene1329	2.796e-73	253.0	COG3839@1|root,COG3839@2|Bacteria,1UJBK@1239|Firmicutes,25F0X@186801|Clostridia,36I6M@31979|Clostridiaceae	186801|Clostridia	G	PFAM ABC transporter related	tupC	-	3.6.3.55	ko:K06857	ko02010,map02010	M00186	R10531	RC00002	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	ABC_tran
HKD1_k127_4423412_0	1540257.JQMW01000014_gene57	5.459e-74	254.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,36IMF@31979|Clostridiaceae	186801|Clostridia	P	inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD1_k127_4423412_4	1540257.JQMW01000014_gene58	1.032e-19	89.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,36ERE@31979|Clostridiaceae	186801|Clostridia	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_4425207_0	469617.FUAG_02155	6.113e-169	539.0	COG0498@1|root,COG0498@2|Bacteria,378C2@32066|Fusobacteria	32066|Fusobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD1_k127_4426924_1	1487921.DP68_18090	1.896e-89	299.0	COG0715@1|root,COG0715@2|Bacteria,1TRT8@1239|Firmicutes,24A1D@186801|Clostridia,36GIW@31979|Clostridiaceae	186801|Clostridia	P	NMT1-like family	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD1_k127_4426924_0	1487921.DP68_18095	0.0	1144.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,36DKP@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	cooS	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD1_k127_4431745_1	646529.Desaci_3857	1.173e-17	88.0	COG1344@1|root,COG1344@2|Bacteria,1TPDT@1239|Firmicutes,248FN@186801|Clostridia,261R5@186807|Peptococcaceae	186801|Clostridia	N	Belongs to the bacterial flagellin family	flgL	-	-	ko:K02397	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flagellin_C,Flagellin_N
HKD1_k127_4431745_0	1120998.AUFC01000003_gene1372	5.228e-81	286.0	COG1256@1|root,COG1256@2|Bacteria,1TPXH@1239|Firmicutes,249PE@186801|Clostridia,3WD8Y@538999|Clostridiales incertae sedis	186801|Clostridia	N	Flagellar basal body rod FlgEFG protein C-terminal	flgK	-	-	ko:K02396	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD1_k127_4433740_1	33035.JPJF01000018_gene4335	5.634e-54	191.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,3XYIV@572511|Blautia	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
HKD1_k127_4433740_0	1469948.JPNB01000002_gene3804	5.012e-132	424.0	COG4868@1|root,COG4868@2|Bacteria,1TQYE@1239|Firmicutes,247YI@186801|Clostridia,36FKP@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0371 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF1846
HKD1_k127_4433820_0	1121335.Clst_0014	6.439e-173	550.0	COG2078@1|root,COG3885@1|root,COG2078@2|Bacteria,COG3885@2|Bacteria,1TQH8@1239|Firmicutes,2491Q@186801|Clostridia,3WHBY@541000|Ruminococcaceae	186801|Clostridia	S	AMMECR1	-	-	-	ko:K06990,ko:K09141	-	-	-	-	ko00000,ko04812	-	-	-	AMMECR1,LigB
HKD1_k127_4433820_1	1321778.HMPREF1982_02930	4.571e-93	310.0	COG1132@1|root,COG1132@2|Bacteria,1UM82@1239|Firmicutes,24ANF@186801|Clostridia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	ko:K18889	ko02010,map02010	M00707	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.106.13,3.A.1.106.5	-	-	ABC_membrane,ABC_tran
HKD1_k127_4434459_2	865861.AZSU01000003_gene1814	2.565e-82	286.0	COG0497@1|root,COG0497@2|Bacteria,1TP99@1239|Firmicutes,247KB@186801|Clostridia,36E7M@31979|Clostridiaceae	186801|Clostridia	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,SMC_N
HKD1_k127_4434459_1	1304284.L21TH_1489	2.057e-85	295.0	COG0750@1|root,COG0750@2|Bacteria,1TPIR@1239|Firmicutes,24AFA@186801|Clostridia,36DRY@31979|Clostridiaceae	186801|Clostridia	M	Stage IV sporulation protein B	spoIVB	-	3.4.21.116	ko:K06399	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S55
HKD1_k127_4434459_0	941824.TCEL_00240	1.284e-101	337.0	COG0745@1|root,COG0745@2|Bacteria,1TPF7@1239|Firmicutes,24916@186801|Clostridia,36EFI@31979|Clostridiaceae	186801|Clostridia	KT	May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process	spo0A	-	-	ko:K07699	ko02020,ko02024,map02020,map02024	M00485	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Spo0A_C
HKD1_k127_4434459_3	1121289.JHVL01000005_gene937	1.343e-38	146.0	COG0494@1|root,COG0494@2|Bacteria,1V6F5@1239|Firmicutes,24JFS@186801|Clostridia,36ITW@31979|Clostridiaceae	186801|Clostridia	L	nudix family	nudF	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD1_k127_4440074_1	1235835.C814_00311	9.663e-16	79.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,3WHET@541000|Ruminococcaceae	186801|Clostridia	P	Calcium-translocating P-type ATPase, PMCA-type	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD1_k127_4440074_0	1292035.H476_0628	2.199e-183	577.0	COG0115@1|root,COG0115@2|Bacteria,1TQQI@1239|Firmicutes,2480D@186801|Clostridia	186801|Clostridia	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42,4.1.3.38	ko:K00826,ko:K02619	ko00270,ko00280,ko00290,ko00770,ko00790,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map00790,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R05553,R10991	RC00006,RC00036,RC01843,RC02148	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_4441275_1	1304284.L21TH_2380	1.328e-71	248.0	COG0218@1|root,COG0218@2|Bacteria,1TSPW@1239|Firmicutes,24836@186801|Clostridia,36EDR@31979|Clostridiaceae	186801|Clostridia	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD1_k127_4441275_3	1304284.L21TH_1463	5.478e-23	103.0	COG2172@1|root,COG2172@2|Bacteria,1VA45@1239|Firmicutes,24PUS@186801|Clostridia,36KYN@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase-like ATPase domain	-	-	2.7.11.1	ko:K04757	-	-	-	-	ko00000,ko01000,ko01001,ko03021	-	-	-	HATPase_c_2
HKD1_k127_4441275_0	1321778.HMPREF1982_02247	8.245e-97	327.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,267T0@186813|unclassified Clostridiales	186801|Clostridia	KL	HELICc2	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
HKD1_k127_4441275_2	580327.Tthe_0830	3.122e-34	137.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,42J4E@68295|Thermoanaerobacterales	186801|Clostridia	KL	SMART helicase	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
HKD1_k127_4444288_1	1304284.L21TH_2586	1.83e-69	240.0	COG1035@1|root,COG1143@1|root,COG1035@2|Bacteria,COG1143@2|Bacteria,1TQGA@1239|Firmicutes,249BE@186801|Clostridia,36GHE@31979|Clostridiaceae	186801|Clostridia	C	hydrogenase beta subunit	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_7,FrhB_FdhB_C,FrhB_FdhB_N
HKD1_k127_4444288_0	1301100.HG529390_gene5070	1.889e-125	403.0	COG0247@1|root,COG0247@2|Bacteria,1TPAM@1239|Firmicutes,24I1E@186801|Clostridia,36WH8@31979|Clostridiaceae	186801|Clostridia	C	lactate metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	CCG
HKD1_k127_4445310_0	1105031.HMPREF1141_0375	5.237e-203	638.0	COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia,36E8K@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the sodium-dependent transport of glutamate	gltC	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HKD1_k127_4445310_1	1009370.ALO_07498	3.526e-07	53.0	COG3758@1|root,COG3758@2|Bacteria,1VH52@1239|Firmicutes,4H5SD@909932|Negativicutes	909932|Negativicutes	S	HutD	-	-	-	-	-	-	-	-	-	-	-	-	HutD
HKD1_k127_4445910_1	573061.Clocel_3477	1.664e-21	94.0	COG1168@1|root,COG1168@2|Bacteria,1TP5G@1239|Firmicutes,248AY@186801|Clostridia,36DKQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Aminotransferase class I and II	patB	-	4.4.1.8	ko:K14155	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	-	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_4445910_0	1449050.JNLE01000005_gene4204	7.092e-168	535.0	COG0626@1|root,COG0626@2|Bacteria,1TPC7@1239|Firmicutes,25E6I@186801|Clostridia,36DC8@31979|Clostridiaceae	186801|Clostridia	E	PFAM Cys Met metabolism	mccB	-	2.5.1.48,4.4.1.8	ko:K01739,ko:K01760	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00782,R00999,R01286,R01288,R02408,R02508,R03217,R03260,R04941,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00382,RC00420,RC00488,RC00710,RC01245,RC02303,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_4446252_0	1408304.JAHA01000003_gene3198	3.84e-163	519.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,4BXTE@830|Butyrivibrio	186801|Clostridia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_4448810_0	1347392.CCEZ01000043_gene202	1.118e-37	149.0	COG3879@1|root,COG3879@2|Bacteria,1V0FG@1239|Firmicutes,24DRC@186801|Clostridia,36GGB@31979|Clostridiaceae	186801|Clostridia	S	Division initiation protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
HKD1_k127_4448810_1	1304284.L21TH_0618	2.772e-26	112.0	COG3879@1|root,COG3879@2|Bacteria,1V66C@1239|Firmicutes,2492Y@186801|Clostridia,36FXV@31979|Clostridiaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF881)	-	-	-	-	-	-	-	-	-	-	-	-	DUF881
HKD1_k127_4449085_0	865861.AZSU01000006_gene1195	2.613e-229	721.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_4451085_3	1469948.JPNB01000002_gene3780	2.792e-12	68.0	2DIV4@1|root,30473@2|Bacteria,1V5EC@1239|Firmicutes,24IZE@186801|Clostridia,36K7X@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4451085_2	1391646.AVSU01000038_gene1969	4.219e-48	174.0	2E6A2@1|root,3182Z@2|Bacteria,1V931@1239|Firmicutes,25JW0@186801|Clostridia,25TMK@186804|Peptostreptococcaceae	186801|Clostridia	S	Coenzyme PQQ synthesis protein D (PqqD)	-	-	-	-	-	-	-	-	-	-	-	-	PqqD
HKD1_k127_4451085_0	332101.JIBU02000047_gene3563	0.0	1004.0	COG1297@1|root,COG1297@2|Bacteria,1TQJP@1239|Firmicutes,247JY@186801|Clostridia,36DEB@31979|Clostridiaceae	186801|Clostridia	S	oligopeptide transporter, OPT family	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD1_k127_4451085_1	1410653.JHVC01000028_gene758	6.339e-272	841.0	COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia,36DNZ@31979|Clostridiaceae	186801|Clostridia	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4452557_0	1120998.AUFC01000003_gene1399	7.409e-85	284.0	COG1536@1|root,COG1536@2|Bacteria,1TP01@1239|Firmicutes,2480B@186801|Clostridia,3WCWV@538999|Clostridiales incertae sedis	186801|Clostridia	N	FliG middle domain	fliG	-	-	ko:K02410	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliG_C,FliG_M,FliG_N
HKD1_k127_4452557_2	1163671.JAGI01000002_gene2995	5.693e-25	114.0	COG1317@1|root,COG1317@2|Bacteria,1VHP9@1239|Firmicutes	1239|Firmicutes	NU	Flagellar assembly protein FliH	-	-	-	-	-	-	-	-	-	-	-	-	FliH
HKD1_k127_4452557_1	1120746.CCNL01000011_gene1474	5.414e-44	165.0	COG1157@1|root,COG1157@2|Bacteria,2NS4J@2323|unclassified Bacteria	2|Bacteria	NU	ATP synthase alpha/beta family, beta-barrel domain	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_4458581_0	1120746.CCNL01000011_gene1655	7.822e-112	368.0	COG0726@1|root,COG0726@2|Bacteria,2NPV2@2323|unclassified Bacteria	2|Bacteria	G	Polysaccharide deacetylase	pdaA	GO:0005575,GO:0016020	3.5.1.104	ko:K01567,ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Polysacc_deac_1
HKD1_k127_4458581_1	994573.T472_0201990	3.531e-65	226.0	COG0503@1|root,COG0503@2|Bacteria,1V1DU@1239|Firmicutes,249VC@186801|Clostridia,36E9V@31979|Clostridiaceae	186801|Clostridia	F	Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis	xpt	-	2.4.2.22	ko:K03816	ko00230,ko01100,ko01110,map00230,map01100,map01110	-	R01229,R02142	RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	Pribosyltran
HKD1_k127_4458581_2	485913.Krac_6352	1.436e-24	106.0	COG0402@1|root,COG0402@2|Bacteria,2G6DG@200795|Chloroflexi	200795|Chloroflexi	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1,CYTH
HKD1_k127_4460694_2	509191.AEDB02000108_gene1668	9.582e-27	111.0	COG1550@1|root,COG1550@2|Bacteria,1VEHY@1239|Firmicutes,24QJY@186801|Clostridia,3WK8N@541000|Ruminococcaceae	186801|Clostridia	S	Protein of unknown function (DUF503)	-	-	-	ko:K09764	-	-	-	-	ko00000	-	-	-	DUF503
HKD1_k127_4460694_0	1294142.CINTURNW_3084	1.082e-74	256.0	COG0177@1|root,COG0177@2|Bacteria,1TRAK@1239|Firmicutes,24899@186801|Clostridia,36DBQ@31979|Clostridiaceae	186801|Clostridia	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD1_k127_4460694_1	1304284.L21TH_0299	9.881e-63	218.0	COG0219@1|root,COG0219@2|Bacteria,1V3GW@1239|Firmicutes,24HVV@186801|Clostridia,36I1E@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily	trmL	-	2.1.1.207	ko:K03216	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	SpoU_methylase
HKD1_k127_4460694_3	658088.HMPREF0987_00626	2.255e-17	84.0	2E36T@1|root,32Y6H@2|Bacteria,1VEXQ@1239|Firmicutes,24RAE@186801|Clostridia,27PBG@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4475361_0	941824.TCEL_01659	4.318e-128	417.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,36E4M@31979|Clostridiaceae	186801|Clostridia	GM	Polysaccharide biosynthesis protein	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
HKD1_k127_4475415_0	1009370.ALO_04181	2.954e-197	626.0	COG1966@1|root,COG1966@2|Bacteria,1TQN8@1239|Firmicutes,4H289@909932|Negativicutes	909932|Negativicutes	T	Carbon starvation protein	-	-	-	ko:K06200	-	-	-	-	ko00000	-	-	-	CstA,CstA_5TM
HKD1_k127_4475415_3	1280692.AUJL01000036_gene370	1.054e-32	127.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,24QJE@186801|Clostridia,36MMP@31979|Clostridiaceae	186801|Clostridia	K	Cold shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_4475415_2	1321778.HMPREF1982_02761	9.594e-66	228.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,26890@186813|unclassified Clostridiales	186801|Clostridia	C	Thioredoxin-like [2Fe-2S] ferredoxin	nuoE	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00334,ko:K18330,ko:K22340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_4475415_1	1499683.CCFF01000017_gene2393	2.114e-93	312.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD1_k127_4478514_1	398512.JQKC01000008_gene942	3.504e-64	227.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,3WNAJ@541000|Ruminococcaceae	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
HKD1_k127_4478514_2	357809.Cphy_2120	1.892e-52	191.0	COG4393@1|root,COG4393@2|Bacteria,1V670@1239|Firmicutes,24HZF@186801|Clostridia,220IT@1506553|Lachnoclostridium	186801|Clostridia	S	Predicted membrane protein (DUF2318)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2318
HKD1_k127_4478514_0	1449050.JNLE01000005_gene4866	4.219e-184	581.0	COG2873@1|root,COG2873@2|Bacteria,1VYCY@1239|Firmicutes,247XK@186801|Clostridia,36UIP@31979|Clostridiaceae	186801|Clostridia	E	O-acetylhomoserine	metY	-	2.5.1.49	ko:K01740	ko00270,ko01100,map00270,map01100	-	R01287,R04859	RC00020,RC02821,RC02848	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD1_k127_4479117_1	994573.T472_0202450	6.778e-76	274.0	2EQKK@1|root,33I6M@2|Bacteria,1VMB1@1239|Firmicutes,24UTW@186801|Clostridia,36Q2D@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4479117_0	994573.T472_0202445	8.598e-119	389.0	COG0226@1|root,COG0226@2|Bacteria,1VT8I@1239|Firmicutes,24IAW@186801|Clostridia	186801|Clostridia	P	PBP superfamily domain	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD1_k127_4479435_2	1304284.L21TH_1087	2.745e-56	203.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36EBZ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_4479435_0	457396.CSBG_01583	7.423e-114	369.0	COG0262@1|root,COG0262@2|Bacteria,1TRY1@1239|Firmicutes,25CP0@186801|Clostridia,36WYJ@31979|Clostridiaceae	186801|Clostridia	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD1_k127_4479435_1	1487921.DP68_03830	5.199e-62	218.0	COG0778@1|root,COG0778@2|Bacteria,1V4ZI@1239|Firmicutes,24BD0@186801|Clostridia,36H2X@31979|Clostridiaceae	186801|Clostridia	C	Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_4482027_0	865861.AZSU01000007_gene1138	9.806e-184	578.0	COG3039@1|root,COG3039@2|Bacteria,1U377@1239|Firmicutes,24ASA@186801|Clostridia,36GEP@31979|Clostridiaceae	186801|Clostridia	L	Transposase domain (DUF772)	-	-	-	-	-	-	-	-	-	-	-	-	DUF772
HKD1_k127_4487921_3	546269.HMPREF0389_01128	1.775e-70	244.0	COG2860@1|root,COG2860@2|Bacteria,1UH1K@1239|Firmicutes,24HHG@186801|Clostridia,25RI3@186804|Peptostreptococcaceae	186801|Clostridia	S	UPF0126 domain	yicG	-	-	-	-	-	-	-	-	-	-	-	UPF0126
HKD1_k127_4487921_1	1304284.L21TH_2665	2.761e-100	332.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,36EFG@31979|Clostridiaceae	186801|Clostridia	O	magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_4487921_0	1121289.JHVL01000003_gene2240	1.213e-103	342.0	COG0606@1|root,COG0606@2|Bacteria,1TPPB@1239|Firmicutes,248T8@186801|Clostridia,36EFG@31979|Clostridiaceae	186801|Clostridia	O	magnesium chelatase	comM	-	-	ko:K07391	-	-	-	-	ko00000	-	-	-	ChlI,Mg_chelatase,Mg_chelatase_C
HKD1_k127_4487921_2	394503.Ccel_2057	3.642e-72	252.0	COG0758@1|root,COG0758@2|Bacteria,1TPP7@1239|Firmicutes,24AS2@186801|Clostridia,36EJZ@31979|Clostridiaceae	186801|Clostridia	LU	DNA protecting protein DprA	dprA	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_449401_0	1301100.HG529274_gene1750	5.075e-141	461.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS_4,PAS_8,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_4504140_3	1540257.JQMW01000014_gene57	2.958e-30	122.0	COG4662@1|root,COG4662@2|Bacteria,1TRK7@1239|Firmicutes,249VG@186801|Clostridia,36IMF@31979|Clostridiaceae	186801|Clostridia	P	inner membrane component	tupB	-	-	ko:K05773	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	BPD_transp_1
HKD1_k127_4504140_1	1540257.JQMW01000014_gene58	1.956e-113	373.0	COG2998@1|root,COG2998@2|Bacteria,1TQA9@1239|Firmicutes,249EZ@186801|Clostridia,36ERE@31979|Clostridiaceae	186801|Clostridia	H	PBP superfamily domain	tupA	-	-	ko:K05772	ko02010,map02010	M00186	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.2,3.A.1.6.4	-	-	PBP_like_2
HKD1_k127_4504140_0	1499683.CCFF01000013_gene124	1.411e-131	434.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36EQ3@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_4504140_2	1499683.CCFF01000013_gene123	1.432e-45	166.0	COG0745@1|root,COG0745@2|Bacteria,1U3FH@1239|Firmicutes,248BR@186801|Clostridia,36FWV@31979|Clostridiaceae	186801|Clostridia	K	PFAM response regulator receiver	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4504679_7	865861.AZSU01000002_gene2537	2.032e-16	86.0	COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,36EW2@31979|Clostridiaceae	186801|Clostridia	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
HKD1_k127_4504679_2	1304284.L21TH_1915	1.167e-160	517.0	COG0305@1|root,COG0305@2|Bacteria,1TPCT@1239|Firmicutes,247W3@186801|Clostridia,36DTR@31979|Clostridiaceae	186801|Clostridia	L	Participates in initiation and elongation during chromosome replication	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD1_k127_4504679_5	562743.JH976434_gene1943	1.969e-42	160.0	COG0359@1|root,COG0359@2|Bacteria,1V6QG@1239|Firmicutes,4HIKJ@91061|Bacilli	91061|Bacilli	J	binds to the 23S rRNA	rplI	GO:0003674,GO:0003676,GO:0003723,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005840,GO:0006412,GO:0006518,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009059,GO:0009987,GO:0010467,GO:0015934,GO:0019538,GO:0022625,GO:0022626,GO:0032991,GO:0034641,GO:0034645,GO:0043043,GO:0043170,GO:0043226,GO:0043228,GO:0043229,GO:0043232,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044260,GO:0044267,GO:0044271,GO:0044391,GO:0044422,GO:0044424,GO:0044444,GO:0044445,GO:0044446,GO:0044464,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901566,GO:1901576,GO:1990904	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD1_k127_4504679_1	1304284.L21TH_1917	3.281e-179	582.0	COG3887@1|root,COG3887@2|Bacteria,1TPGP@1239|Firmicutes,2484R@186801|Clostridia,36E60@31979|Clostridiaceae	186801|Clostridia	T	domain protein	yybT	-	-	-	-	-	-	-	-	-	-	-	DHH,DHHA1
HKD1_k127_4504679_6	1304284.L21TH_1918	1.854e-27	124.0	COG4241@1|root,COG4241@2|Bacteria,1V8P8@1239|Firmicutes,25CRW@186801|Clostridia,36WZT@31979|Clostridiaceae	186801|Clostridia	S	Predicted membrane protein (DUF2232)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2232
HKD1_k127_4504679_3	1304284.L21TH_0141	8.05e-124	411.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,36DR5@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	-	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,PG_binding_1,Peptidase_S41
HKD1_k127_4504679_0	1120998.AUFC01000019_gene272	3.009e-222	699.0	COG0119@1|root,COG0119@2|Bacteria,1TP4Y@1239|Firmicutes,2485A@186801|Clostridia,3WCX9@538999|Clostridiales incertae sedis	186801|Clostridia	E	Belongs to the alpha-IPM synthase homocitrate synthase family	leuA	-	2.3.3.13	ko:K01649	ko00290,ko00620,ko01100,ko01110,ko01210,ko01230,map00290,map00620,map01100,map01110,map01210,map01230	M00432	R01213	RC00004,RC00470,RC02754	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	HMGL-like,LeuA_dimer
HKD1_k127_4504679_4	1514668.JOOA01000002_gene1616	1.868e-96	318.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,3WG9G@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01703,ko:K20452	ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04465	Aconitase
HKD1_k127_4515843_0	748727.CLJU_c07050	1.327e-42	159.0	COG3383@1|root,COG3383@2|Bacteria,1V5BD@1239|Firmicutes,24ER9@186801|Clostridia,36HTC@31979|Clostridiaceae	186801|Clostridia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	iHN637.CLJU_RS03470	Fer2_4,Fer4,Fer4_21,Fer4_7
HKD1_k127_4532625_1	1121289.JHVL01000002_gene2365	8.831e-25	106.0	COG0268@1|root,COG0268@2|Bacteria,1VEGX@1239|Firmicutes,24QNX@186801|Clostridia,36KIE@31979|Clostridiaceae	186801|Clostridia	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD1_k127_4532625_0	1128398.Curi_c18360	2.962e-71	250.0	COG0680@1|root,COG0680@2|Bacteria,1TPFY@1239|Firmicutes,248TE@186801|Clostridia,268BG@186813|unclassified Clostridiales	186801|Clostridia	C	Initiates the rapid degradation of small, acid-soluble proteins during spore germination	gpr	-	3.4.24.78	ko:K06012	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_A25
HKD1_k127_4538515_1	941824.TCEL_00834	4.431e-37	147.0	COG0115@1|root,COG0115@2|Bacteria,1TPY2@1239|Firmicutes,25930@186801|Clostridia,36DVP@31979|Clostridiaceae	186801|Clostridia	EH	Aminotransferase class IV	ilvE2	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD1_k127_4538515_0	536232.CLM_0603	9.765e-51	186.0	COG1199@1|root,COG1199@2|Bacteria,1TPNB@1239|Firmicutes,248ZI@186801|Clostridia,36E0Y@31979|Clostridiaceae	186801|Clostridia	L	helicase	dinG	-	3.1.12.1,3.6.4.12	ko:K07464,ko:K10844	ko03022,ko03420,map03022,map03420	M00290	-	-	ko00000,ko00001,ko00002,ko01000,ko02048,ko03021,ko03400	-	-	-	DEAD,DEAD_2,HBB,Helicase_C_2,PDDEXK_1
HKD1_k127_4541952_0	515620.EUBELI_01877	8.323e-82	282.0	COG0604@1|root,COG0604@2|Bacteria,1TT5J@1239|Firmicutes,24H1R@186801|Clostridia,25Y5Q@186806|Eubacteriaceae	186801|Clostridia	C	alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4541952_1	515620.EUBELI_01878	1.241e-43	161.0	COG1695@1|root,COG1695@2|Bacteria,1V85H@1239|Firmicutes,24N2G@186801|Clostridia,25ZGS@186806|Eubacteriaceae	186801|Clostridia	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD1_k127_4541952_2	1121085.AUCI01000007_gene1129	1.579e-28	123.0	COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,4HB2I@91061|Bacilli,1ZCTW@1386|Bacillus	91061|Bacilli	C	Na+/H+ antiporter family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
HKD1_k127_4567934_0	1120998.AUFC01000008_gene1046	2.636e-166	534.0	COG1057@1|root,COG1057@2|Bacteria,1TQVJ@1239|Firmicutes,249M0@186801|Clostridia	186801|Clostridia	H	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD1_k127_4575770_1	1120985.AUMI01000007_gene2519	2.199e-40	151.0	COG0191@1|root,COG0191@2|Bacteria,1TRS4@1239|Firmicutes,4H3EE@909932|Negativicutes	909932|Negativicutes	G	Fructose-bisphosphate aldolase class-II	-	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_4575770_0	887929.HMP0721_0501	2.862e-176	564.0	COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia,25WGH@186806|Eubacteriaceae	186801|Clostridia	EG	gluconate H symporter	-	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
HKD1_k127_4575770_2	1122222.AXWR01000010_gene76	3.758e-07	55.0	COG1070@1|root,COG1070@2|Bacteria,1WITI@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	G	PFAM FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17,2.7.1.189	ko:K00854,ko:K11216	ko00040,ko01100,ko02024,map00040,map01100,map02024	M00014	R01639,R11183	RC00002,RC00017,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_4582047_3	332101.JIBU02000013_gene1216	1.843e-39	152.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,36DF8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_4582047_1	1128398.Curi_c12970	1.759e-96	325.0	COG0769@1|root,COG0769@2|Bacteria,1TPQE@1239|Firmicutes,248Q4@186801|Clostridia,267UW@186813|unclassified Clostridiales	186801|Clostridia	M	acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_4582047_0	1304284.L21TH_0612	1.451e-126	412.0	COG0472@1|root,COG0472@2|Bacteria,1TP8W@1239|Firmicutes,247S7@186801|Clostridia,36DPY@31979|Clostridiaceae	186801|Clostridia	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD1_k127_4582047_2	1128398.Curi_c12990	9.175e-70	244.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,2689Q@186813|unclassified Clostridiales	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_458460_0	994573.T472_0207875	1.394e-104	349.0	28IH1@1|root,2Z8IC@2|Bacteria,1TSE5@1239|Firmicutes,249UI@186801|Clostridia,36DYP@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF4003)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4003
HKD1_k127_458460_1	1131462.DCF50_p1696	1.143e-56	203.0	28MX3@1|root,2ZB49@2|Bacteria,1V7PT@1239|Firmicutes,25CZN@186801|Clostridia,262I0@186807|Peptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF3795)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3795
HKD1_k127_4584678_0	457570.Nther_0318	7.931e-74	263.0	COG1146@1|root,COG2006@1|root,COG1146@2|Bacteria,COG2006@2|Bacteria,1TRX2@1239|Firmicutes,249GX@186801|Clostridia	186801|Clostridia	C	binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF362,Fer4,Fer4_10,Fer4_7
HKD1_k127_4589611_1	1121324.CLIT_10c04100	2.334e-62	216.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,25QJ4@186804|Peptostreptococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score	appF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_4589611_0	1121289.JHVL01000017_gene728	2.556e-182	587.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,36EHU@31979|Clostridiaceae	186801|Clostridia	E	Family 5	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_4589611_2	1304284.L21TH_0331	8.27e-12	66.0	COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,24PNN@186801|Clostridia,36HKQ@31979|Clostridiaceae	186801|Clostridia	S	Sucrose-6F-phosphate phosphohydrolase	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD1_k127_4592923_1	1487921.DP68_01140	7.593e-54	192.0	COG0374@1|root,COG0374@2|Bacteria,1TQMW@1239|Firmicutes,248BB@186801|Clostridia,36F7N@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the NiFe NiFeSe hydrogenase large subunit family	hupL	-	1.12.99.6	ko:K06281	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFeSe_Hases
HKD1_k127_4592923_0	1487921.DP68_01135	4.106e-140	448.0	COG1740@1|root,COG1740@2|Bacteria,1TZZD@1239|Firmicutes,2489B@186801|Clostridia,36EWC@31979|Clostridiaceae	186801|Clostridia	C	Hydrogenase (NiFe) small subunit HydA	hupS	-	1.12.99.6	ko:K06282	ko00633,ko01120,map00633,map01120	-	R08034	RC00250	ko00000,ko00001,ko01000	-	-	-	NiFe_hyd_SSU_C,Oxidored_q6,TAT_signal
HKD1_k127_4599174_0	1121289.JHVL01000014_gene1801	1.213e-127	419.0	COG2081@1|root,COG2081@2|Bacteria,1TQ6E@1239|Firmicutes,247S5@186801|Clostridia,36E7B@31979|Clostridiaceae	186801|Clostridia	S	HI0933 family	-	-	-	ko:K07007	-	-	-	-	ko00000	-	-	-	HI0933_like
HKD1_k127_4599174_1	886293.Sinac_5187	2.224e-28	116.0	COG0367@1|root,COG0367@2|Bacteria,2IXAI@203682|Planctomycetes	203682|Planctomycetes	E	Asparagine synthase, glutamine-hydrolyzing	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD1_k127_4605283_0	1304284.L21TH_0610	3.18e-215	687.0	COG0768@1|root,COG0768@2|Bacteria,1TP93@1239|Firmicutes,248KB@186801|Clostridia,36DJT@31979|Clostridiaceae	186801|Clostridia	M	stage V sporulation protein D	spoVD	-	3.4.16.4	ko:K03587,ko:K08384	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PASTA,PBP_dimer,Transpeptidase
HKD1_k127_4619829_0	1121289.JHVL01000003_gene2320	1.754e-148	481.0	COG0699@1|root,COG0699@2|Bacteria,1TPPG@1239|Firmicutes,24829@186801|Clostridia,36DMZ@31979|Clostridiaceae	186801|Clostridia	S	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	spoIVA	GO:0000003,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008150,GO:0009653,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019954,GO:0030154,GO:0030312,GO:0030435,GO:0030436,GO:0030554,GO:0031160,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0034301,GO:0035639,GO:0036094,GO:0042601,GO:0042763,GO:0043167,GO:0043168,GO:0043934,GO:0043936,GO:0044464,GO:0048646,GO:0048856,GO:0048869,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06398	-	-	-	-	ko00000	-	-	-	Spore_IV_A
HKD1_k127_4619829_1	1120998.AUFC01000001_gene1901	1.926e-05	51.0	COG0845@1|root,COG0845@2|Bacteria,1VBFZ@1239|Firmicutes,24MZ7@186801|Clostridia	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4626480_0	86416.Clopa_2114	3.926e-122	413.0	COG0642@1|root,COG2205@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_4632231_0	1121289.JHVL01000043_gene1087	1.174e-155	503.0	COG0486@1|root,COG0486@2|Bacteria,1TPJF@1239|Firmicutes,248A9@186801|Clostridia,36ECR@31979|Clostridiaceae	186801|Clostridia	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD1_k127_4632231_1	1347392.CCEZ01000010_gene2395	5.31e-18	85.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,36E85@31979|Clostridiaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD1_k127_4635942_0	1499683.CCFF01000016_gene918	1.365e-147	472.0	COG0531@1|root,COG0531@2|Bacteria,1TSSB@1239|Firmicutes,25B81@186801|Clostridia,36WAW@31979|Clostridiaceae	186801|Clostridia	E	amino acid	arcD	-	-	ko:K03758	-	-	-	-	ko00000,ko02000	2.A.3.2	-	-	AA_permease_2
HKD1_k127_4635942_1	1294142.CINTURNW_3138	2.803e-09	59.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,36JKN@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD1_k127_4642655_1	350688.Clos_0058	1.968e-43	172.0	COG1835@1|root,COG1835@2|Bacteria,1U367@1239|Firmicutes,24SVV@186801|Clostridia,36VY9@31979|Clostridiaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD1_k127_4642655_0	350688.Clos_0058	6.644e-50	191.0	COG1835@1|root,COG1835@2|Bacteria,1U367@1239|Firmicutes,24SVV@186801|Clostridia,36VY9@31979|Clostridiaceae	186801|Clostridia	I	Acyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Acyl_transf_3
HKD1_k127_4642655_2	1120998.AUFC01000004_gene2340	2.426e-20	93.0	COG1476@1|root,COG1476@2|Bacteria,1UJZ9@1239|Firmicutes,25FFF@186801|Clostridia	186801|Clostridia	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_26
HKD1_k127_4650519_0	997350.HMPREF9129_1763	7.119e-118	388.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,22G27@1570339|Peptoniphilaceae	186801|Clostridia	C	Six-Cys-in-45 modification radical SAM protein	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_4650519_1	696281.Desru_3873	2.116e-13	70.0	2EGRK@1|root,33AHS@2|Bacteria,1VK9R@1239|Firmicutes,24UM0@186801|Clostridia,26382@186807|Peptococcaceae	186801|Clostridia	S	six-cysteine peptide SCIFF	scfA	-	-	-	-	-	-	-	-	-	-	-	SCIFF
HKD1_k127_4657876_1	1121335.Clst_0946	2.974e-133	428.0	COG1003@1|root,COG1003@2|Bacteria,1TPK9@1239|Firmicutes,2480Q@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS11880	GDC-P
HKD1_k127_4657876_0	37659.JNLN01000001_gene424	9.465e-153	496.0	COG1249@1|root,COG1249@2|Bacteria,1TP1W@1239|Firmicutes,249R3@186801|Clostridia,36EPX@31979|Clostridiaceae	186801|Clostridia	C	Dihydrolipoyl dehydrogenase	lpdA	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD1_k127_4657876_2	913865.DOT_2599	2.017e-94	315.0	COG0095@1|root,COG0095@2|Bacteria,1TQ5U@1239|Firmicutes,247S9@186801|Clostridia,260HQ@186807|Peptococcaceae	186801|Clostridia	H	biotin lipoate A B protein ligase	lplA	-	6.3.1.20	ko:K03800	ko00785,ko01100,map00785,map01100	-	R07770,R07771,R11143	RC00043,RC00070,RC00090,RC00992,RC02896	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB,Lip_prot_lig_C
HKD1_k127_4662796_0	1121115.AXVN01000081_gene3054	5.51e-79	271.0	COG1641@1|root,COG1641@2|Bacteria,1TPAV@1239|Firmicutes,247ZH@186801|Clostridia,3XZGY@572511|Blautia	186801|Clostridia	S	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes	larC	-	4.99.1.12	ko:K09121	-	-	-	-	ko00000,ko01000	-	-	-	DUF111
HKD1_k127_4662796_1	1304284.L21TH_1659	4.043e-21	94.0	2CIJU@1|root,332RU@2|Bacteria,1VESI@1239|Firmicutes,24QR7@186801|Clostridia,36MZM@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1893)	-	-	-	-	-	-	-	-	-	-	-	-	TM1506
HKD1_k127_4663855_0	332101.JIBU02000001_gene4337	1.948e-141	454.0	COG3426@1|root,COG3426@2|Bacteria,1TPKE@1239|Firmicutes,24993@186801|Clostridia,36GMK@31979|Clostridiaceae	186801|Clostridia	C	PFAM acetate and butyrate kinase	buk	-	2.7.2.7	ko:K00929	ko00650,ko01100,map00650,map01100	-	R01688	RC00002,RC00043	ko00000,ko00001,ko01000	-	-	-	Acetate_kinase
HKD1_k127_4663855_1	1235835.C814_02064	1.832e-140	459.0	COG2244@1|root,COG2244@2|Bacteria,1TR7A@1239|Firmicutes,24C7V@186801|Clostridia,3WGB1@541000|Ruminococcaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_4670859_0	537013.CLOSTMETH_01551	6.237e-99	341.0	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,3WGTJ@541000|Ruminococcaceae	186801|Clostridia	S	Stage V sporulation protein B	spoVB	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_4670859_1	1499683.CCFF01000017_gene2545	6.557e-93	313.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,36F1U@31979|Clostridiaceae	186801|Clostridia	C	aldo keto reductase	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17,Fer4_9
HKD1_k127_4673317_1	1211814.CAPG01000069_gene3238	8.357e-42	158.0	28ITW@1|root,2Z8SQ@2|Bacteria,1TSYI@1239|Firmicutes,4HADC@91061|Bacilli,1ZDIW@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4673317_0	1195236.CTER_0260	3.548e-55	197.0	COG1172@1|root,COG1172@2|Bacteria,1UYG4@1239|Firmicutes,24A8M@186801|Clostridia	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD1_k127_4677098_1	485916.Dtox_3757	1.776e-157	501.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,2490X@186801|Clostridia,260IH@186807|Peptococcaceae	186801|Clostridia	C	TIGRFAM glutamate synthases, NADH NADPH, small subunit	gltD	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2
HKD1_k127_4677098_0	445973.CLOBAR_00846	2.006e-187	592.0	COG0486@1|root,COG0486@2|Bacteria,1TQA8@1239|Firmicutes,247M4@186801|Clostridia,25QWW@186804|Peptostreptococcaceae	186801|Clostridia	S	maturation GTPase HydF	hydF	-	-	-	-	-	-	-	-	-	-	-	MMR_HSR1
HKD1_k127_4677098_2	500632.CLONEX_02834	8.262e-106	345.0	COG0502@1|root,COG0502@2|Bacteria,1TPEX@1239|Firmicutes,248PF@186801|Clostridia	186801|Clostridia	C	biosynthesis protein ThiH	hydG	-	4.1.99.19	ko:K03150	ko00730,ko01100,map00730,map01100	-	R10246	RC01434,RC03095	ko00000,ko00001,ko01000	-	-	-	BATS,Radical_SAM
HKD1_k127_4681038_0	931276.Cspa_c50420	5.676e-210	655.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_4681038_1	1301100.HG529270_gene564	4.341e-168	531.0	28H7K@1|root,2Z7JT@2|Bacteria,1UPH1@1239|Firmicutes,249YA@186801|Clostridia,36DRU@31979|Clostridiaceae	186801|Clostridia	P	2-keto-3-deoxygluconate permease	kdgT	-	-	ko:K02526	-	-	-	-	ko00000,ko02000	2.A.10.1	-	-	KdgT
HKD1_k127_4688466_0	1122921.KB898197_gene1279	1.503e-49	188.0	COG5279@1|root,COG5279@2|Bacteria,1U58R@1239|Firmicutes,4HHGR@91061|Bacilli,26UGJ@186822|Paenibacillaceae	91061|Bacilli	D	protein involved in cytokinesis, contains TGc (transglutaminase protease-like) domain	KY	-	-	-	-	-	-	-	-	-	-	-	DUF5050,Transglut_core
HKD1_k127_4688466_1	875454.BAEW01000001_gene26	6.681e-29	118.0	COG0617@1|root,COG0617@2|Bacteria,1TQ2A@1239|Firmicutes,247XC@186801|Clostridia,22GEC@1570339|Peptoniphilaceae	186801|Clostridia	J	Poly A polymerase head domain	cca	-	2.7.7.19,2.7.7.72	ko:K00970,ko:K00974	ko03013,ko03018,map03013,map03018	-	R09382,R09383,R09384,R09386	RC00078	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	HD,PolyA_pol,PolyA_pol_RNAbd,tRNA_NucTran2_2
HKD1_k127_4688538_1	1121342.AUCO01000005_gene336	4.945e-62	216.0	COG0105@1|root,COG0105@2|Bacteria,1V44G@1239|Firmicutes,24JM5@186801|Clostridia,36JJ1@31979|Clostridiaceae	186801|Clostridia	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD1_k127_4688538_2	1121007.AUML01000006_gene3098	9.111e-42	160.0	COG1670@1|root,COG1670@2|Bacteria,4NSIH@976|Bacteroidetes,1I4PX@117743|Flavobacteriia,2YJD0@290174|Aquimarina	976|Bacteroidetes	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_4688538_0	272563.CD630_02950	3.998e-194	609.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,25RCA@186804|Peptostreptococcaceae	186801|Clostridia	C	Domain of unknown function (DUF362)	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_7
HKD1_k127_4691223_1	1195236.CTER_0380	1.658e-41	156.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24A6G@186801|Clostridia	186801|Clostridia	G	TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD1_k127_4691223_0	1410632.JHWW01000001_gene1030	3.692e-236	739.0	COG1070@1|root,COG1070@2|Bacteria,1TQ1I@1239|Firmicutes,247NR@186801|Clostridia,27IKI@186928|unclassified Lachnospiraceae	186801|Clostridia	G	FGGY family of carbohydrate kinases, N-terminal domain	xylB	-	2.7.1.17	ko:K00854	ko00040,ko01100,map00040,map01100	M00014	R01639	RC00002,RC00538	ko00000,ko00001,ko00002,ko01000	-	-	-	FGGY_C,FGGY_N
HKD1_k127_4693646_3	457415.HMPREF1006_00389	1.696e-47	172.0	COG3968@1|root,COG3968@2|Bacteria,3TAD6@508458|Synergistetes	2|Bacteria	S	PFAM Glutamine synthetase, catalytic	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
HKD1_k127_4693646_0	537013.CLOSTMETH_00827	3.25e-191	601.0	COG3968@1|root,COG3968@2|Bacteria,1UHUF@1239|Firmicutes,2481B@186801|Clostridia,3WHCK@541000|Ruminococcaceae	186801|Clostridia	S	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	GSIII_N,Gln-synt_C
HKD1_k127_4693646_1	537013.CLOSTMETH_00820	1.362e-189	601.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,3WGBE@541000|Ruminococcaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD1_k127_4693646_2	537013.CLOSTMETH_00819	2.806e-59	211.0	COG3707@1|root,COG3707@2|Bacteria,1V9FH@1239|Firmicutes,24JZU@186801|Clostridia,3WJ90@541000|Ruminococcaceae	186801|Clostridia	K	ANTAR domain protein	-	-	-	ko:K22010	-	M00839	-	-	ko00000,ko00002,ko02022	-	-	-	ANTAR,Response_reg
HKD1_k127_4693646_4	555079.Toce_0657	2.238e-07	53.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,42F1D@68295|Thermoanaerobacterales	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_4693815_1	1230342.CTM_10231	5.488e-17	84.0	COG1633@1|root,COG1633@2|Bacteria,1V860@1239|Firmicutes,24ERW@186801|Clostridia,36EYA@31979|Clostridiaceae	186801|Clostridia	G	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_4693815_0	1487921.DP68_16590	3.011e-140	449.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia,36EYP@31979|Clostridiaceae	186801|Clostridia	L	helicase	cshA2	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,Helicase_C
HKD1_k127_4697007_6	742740.HMPREF9474_00159	5.982e-24	102.0	COG0745@1|root,COG0745@2|Bacteria,1VV7N@1239|Firmicutes,24CC8@186801|Clostridia	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_4697007_0	742741.HMPREF9475_00669	3.07e-201	644.0	COG0642@1|root,COG2205@2|Bacteria,1UMXJ@1239|Firmicutes,25GRV@186801|Clostridia	186801|Clostridia	T	Cache 3/Cache 2 fusion domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,dCache_1
HKD1_k127_4697007_1	742741.HMPREF9475_00450	1.415e-155	500.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,21XNG@1506553|Lachnoclostridium	186801|Clostridia	E	Receptor family ligand binding region	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_4697007_2	742741.HMPREF9475_00451	7.141e-124	402.0	COG0559@1|root,COG0559@2|Bacteria,1V2WK@1239|Firmicutes,24GFW@186801|Clostridia,223Z8@1506553|Lachnoclostridium	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_4697007_3	742741.HMPREF9475_00452	1.71e-116	381.0	COG4177@1|root,COG4177@2|Bacteria,1UZ69@1239|Firmicutes,24EFF@186801|Clostridia,223YU@1506553|Lachnoclostridium	186801|Clostridia	U	Branched-chain amino acid transport system / permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_2
HKD1_k127_4697007_4	742741.HMPREF9475_00453	3.762e-116	378.0	COG0411@1|root,COG0411@2|Bacteria,1V3CC@1239|Firmicutes,24GSP@186801|Clostridia,220N4@1506553|Lachnoclostridium	186801|Clostridia	E	Branched-chain amino acid ATP-binding cassette transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_4697007_5	742741.HMPREF9475_00454	2.395e-97	322.0	COG0410@1|root,COG0410@2|Bacteria,1V39C@1239|Firmicutes,24G7J@186801|Clostridia,223T8@1506553|Lachnoclostridium	186801|Clostridia	E	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD1_k127_4698851_0	877421.AUJT01000003_gene3288	2.936e-182	582.0	COG1492@1|root,COG1492@2|Bacteria,1TP5E@1239|Firmicutes,248XW@186801|Clostridia,27IVY@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation	cobQ	-	6.3.5.10	ko:K02232	ko00860,ko01100,map00860,map01100	M00122	R05225	RC00010,RC01302	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS15780	AAA_26,CbiA,GATase_3
HKD1_k127_4698851_1	1262914.BN533_01689	1.151e-23	104.0	COG2073@1|root,COG2073@2|Bacteria,1TPYM@1239|Firmicutes,4H2SI@909932|Negativicutes	909932|Negativicutes	H	CbiG protein	cbiG	-	3.7.1.12	ko:K02189	ko00860,ko01100,map00860,map01100	-	R07772	RC01545,RC02097	ko00000,ko00001,ko01000	-	-	-	CbiG_C,CbiG_N,CbiG_mid
HKD1_k127_471069_0	1297617.JPJD01000035_gene644	3.541e-144	464.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,26AUJ@186813|unclassified Clostridiales	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_471069_1	1297617.JPJD01000035_gene643	3.392e-47	171.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,269ZR@186813|unclassified Clostridiales	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_4712780_2	1449050.JNLE01000003_gene1032	1.074e-44	162.0	COG3260@1|root,COG3260@2|Bacteria,1UHYA@1239|Firmicutes,24I1D@186801|Clostridia,36IQV@31979|Clostridiaceae	186801|Clostridia	C	NADH ubiquinone oxidoreductase	-	-	1.6.5.3	ko:K00331,ko:K14088	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD1_k127_4712780_1	1304866.K413DRAFT_4402	5.582e-138	443.0	COG0650@1|root,COG0650@2|Bacteria,1UIUW@1239|Firmicutes,249VU@186801|Clostridia,36UYP@31979|Clostridiaceae	186801|Clostridia	C	NADH dehydrogenase	-	-	1.6.5.3	ko:K00337,ko:K14087	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD1_k127_4712780_0	203119.Cthe_3024	5.939e-157	501.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,3WHSP@541000|Ruminococcaceae	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	-	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_4721466_0	1304284.L21TH_0303	1.688e-144	467.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,36EX4@31979|Clostridiaceae	186801|Clostridia	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4721466_1	1077285.AGDG01000045_gene2960	3.363e-72	248.0	COG2109@1|root,COG2109@2|Bacteria,4NNX3@976|Bacteroidetes,2FRZZ@200643|Bacteroidia,4AQPQ@815|Bacteroidaceae	976|Bacteroidetes	H	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP	cobO	-	2.5.1.17	ko:K19221	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	CobA_CobO_BtuR
HKD1_k127_4721967_2	1345695.CLSA_c33400	2.975e-83	279.0	COG1051@1|root,COG1051@2|Bacteria,1V1P7@1239|Firmicutes,24FSG@186801|Clostridia,36HYH@31979|Clostridiaceae	186801|Clostridia	F	hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD1_k127_4721967_1	86416.Clopa_4741	3.333e-101	337.0	COG0454@1|root,COG0456@2|Bacteria,1VXZ6@1239|Firmicutes,24IUM@186801|Clostridia,36J8V@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_4721967_0	1507.HMPREF0262_02077	2.952e-123	405.0	COG0624@1|root,COG0624@2|Bacteria,1TYR6@1239|Firmicutes,249CA@186801|Clostridia,36EZ9@31979|Clostridiaceae	186801|Clostridia	E	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD1_k127_4721967_3	865861.AZSU01000005_gene824	4.312e-21	93.0	COG0460@1|root,COG0460@2|Bacteria,1URXW@1239|Firmicutes,248ZK@186801|Clostridia,36E75@31979|Clostridiaceae	186801|Clostridia	E	Homoserine dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Homoserine_dh,NAD_binding_3
HKD1_k127_4725938_1	2325.TKV_c18690	9.778e-21	94.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,42FES@68295|Thermoanaerobacterales	186801|Clostridia	HP	TIGRFAM molybdenum cofactor synthesis	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HKD1_k127_4725938_0	1540257.JQMW01000010_gene1326	2.056e-108	356.0	COG0303@1|root,COG0303@2|Bacteria,1TQJ8@1239|Firmicutes,248WP@186801|Clostridia,36E4B@31979|Clostridiaceae	186801|Clostridia	H	Molybdenum cofactor synthesis domain	moeA	-	2.10.1.1	ko:K03750	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N
HKD1_k127_4726511_1	642492.Clole_1635	2.499e-84	288.0	COG1307@1|root,COG1307@2|Bacteria,1TYCV@1239|Firmicutes,248JV@186801|Clostridia	186801|Clostridia	S	EDD domain protein, DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_4726511_3	536227.CcarbDRAFT_0486	3.563e-56	199.0	COG1846@1|root,COG1846@2|Bacteria,1VB3Q@1239|Firmicutes,25CPU@186801|Clostridia,36WYX@31979|Clostridiaceae	186801|Clostridia	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD1_k127_4726511_7	748727.CLJU_c16990	1.192e-21	95.0	COG2846@1|root,COG2846@2|Bacteria	2|Bacteria	D	Di-iron-containing protein involved in the repair of iron-sulfur clusters	-	-	-	ko:K07322	-	-	-	-	ko00000	-	-	-	DUF1858,Hemerythrin
HKD1_k127_4726511_2	931276.Cspa_c37680	2.05e-57	202.0	COG1251@1|root,COG1251@2|Bacteria,1V7TQ@1239|Firmicutes,24IH0@186801|Clostridia,36J81@31979|Clostridiaceae	186801|Clostridia	C	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
HKD1_k127_4726511_6	1321778.HMPREF1982_01284	2.654e-23	100.0	2EHCX@1|root,33B4S@2|Bacteria,1VKA0@1239|Firmicutes,24QT9@186801|Clostridia	186801|Clostridia	S	Spore coat associated protein JA (CotJA)	-	-	-	-	-	-	-	-	-	-	-	-	CotJA
HKD1_k127_4726511_0	1230342.CTM_15977	1.595e-108	353.0	COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,36EF8@31979|Clostridiaceae	186801|Clostridia	P	PFAM Manganese containing catalase	cotJC	-	-	ko:K06334	-	-	-	-	ko00000	-	-	-	Mn_catalase
HKD1_k127_4728609_1	931276.Cspa_c46790	1.74e-131	421.0	COG0813@1|root,COG0813@2|Bacteria,1TQPG@1239|Firmicutes,248G6@186801|Clostridia,36DR4@31979|Clostridiaceae	186801|Clostridia	F	Purine nucleoside phosphorylase	deoD	-	2.4.2.1	ko:K03784	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R01561,R01863,R01969,R02147,R02294,R02295,R02297,R02484,R02557,R02748,R08368,R10244	RC00033,RC00063,RC00122	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_4728609_0	290402.Cbei_3124	1.017e-137	440.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,36EW8@31979|Clostridiaceae	186801|Clostridia	S	basic membrane	bmpA	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD1_k127_4729518_0	1499689.CCNN01000007_gene1170	3.532e-35	146.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_4732194_1	1408422.JHYF01000008_gene3744	2.74e-12	68.0	COG2155@1|root,COG2155@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF378)	CP_0775	-	-	ko:K09779	-	-	-	-	ko00000	-	-	-	DUF378
HKD1_k127_4732194_0	1304284.L21TH_0331	5.4e-61	220.0	COG0561@1|root,COG0561@2|Bacteria,1TREF@1239|Firmicutes,24PNN@186801|Clostridia,36HKQ@31979|Clostridiaceae	186801|Clostridia	S	Sucrose-6F-phosphate phosphohydrolase	yidA	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_3
HKD1_k127_4732194_2	742738.HMPREF9460_02618	3.538e-05	47.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,2682G@186813|unclassified Clostridiales	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	oppA	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_4736668_1	1121289.JHVL01000013_gene1620	3.956e-27	119.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_4736668_0	1304284.L21TH_1092	1.52e-139	449.0	COG0205@1|root,COG0205@2|Bacteria,1TPF4@1239|Firmicutes,248PB@186801|Clostridia,36DGA@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis	pfkA	-	2.7.1.11	ko:K00850	ko00010,ko00030,ko00051,ko00052,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04152,ko05230,map00010,map00030,map00051,map00052,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04152,map05230	M00001,M00345	R00756,R03236,R03237,R03238,R03239,R04779	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000,ko01009,ko03019	-	-	-	PFK
HKD1_k127_4747661_0	1347392.CCEZ01000018_gene1075	1.52e-168	539.0	COG1362@1|root,COG1362@2|Bacteria,1TP6G@1239|Firmicutes,2486Y@186801|Clostridia,36F9C@31979|Clostridiaceae	186801|Clostridia	E	M18 family aminopeptidase	apeA	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M18
HKD1_k127_4752004_0	1120998.AUFC01000034_gene1349	9.167e-121	403.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal,dCache_1
HKD1_k127_4752004_1	1304866.K413DRAFT_1096	6.779e-10	64.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36DH1@31979|Clostridiaceae	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
HKD1_k127_4754191_0	1444309.JAQG01000090_gene1233	2.826e-108	355.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,4H9WY@91061|Bacilli,26QDF@186822|Paenibacillaceae	91061|Bacilli	E	ABC transporter, ATP-binding protein	tcyN	-	-	ko:K16960	ko02010,map02010	M00585	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.3.13	-	-	ABC_tran
HKD1_k127_4754191_1	1121334.KB911066_gene786	5.545e-81	274.0	COG0834@1|root,COG0834@2|Bacteria,1UX4B@1239|Firmicutes,24G1J@186801|Clostridia	186801|Clostridia	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K16957	ko02010,map02010	M00585	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.13	-	-	SBP_bac_3
HKD1_k127_4754849_0	748727.CLJU_c12750	4.438e-45	169.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,36DM0@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0348 family	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
HKD1_k127_4754849_1	1347392.CCEZ01000043_gene56	2.012e-41	157.0	2E12M@1|root,32WIA@2|Bacteria,1VD2B@1239|Firmicutes,24NKB@186801|Clostridia,36M1W@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4755180_3	938278.CAJO01000011_gene1871	6.067e-22	99.0	COG3697@1|root,COG3697@2|Bacteria,1VB3E@1239|Firmicutes,24MQ6@186801|Clostridia	186801|Clostridia	HI	PFAM Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase	citX	-	2.7.7.61	ko:K05964	ko02020,map02020	-	R10706	-	ko00000,ko00001,ko01000	-	-	-	CitX
HKD1_k127_4755180_4	1449343.JQLQ01000002_gene623	8.409e-06	48.0	COG1767@1|root,COG1767@2|Bacteria,1TQGQ@1239|Firmicutes,4HGCS@91061|Bacilli,27HD4@186828|Carnobacteriaceae	91061|Bacilli	H	ATP:dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
HKD1_k127_4755180_2	1410668.JNKC01000020_gene890	6.59e-74	255.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,36IAW@31979|Clostridiaceae	186801|Clostridia	K	GntR family	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_4755180_0	1280689.AUJC01000007_gene3289	5.504e-171	544.0	COG0538@1|root,COG0538@2|Bacteria,1TSKB@1239|Firmicutes,247KX@186801|Clostridia,36GE7@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_4755180_1	293826.Amet_3215	1.855e-93	316.0	COG0583@1|root,COG0583@2|Bacteria,1UZ63@1239|Firmicutes,25C72@186801|Clostridia,36WQQ@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, LysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_4755464_0	767817.Desgi_3510	1.719e-132	430.0	COG2110@1|root,COG2110@2|Bacteria,1TPCU@1239|Firmicutes,24ARG@186801|Clostridia,261T9@186807|Peptococcaceae	186801|Clostridia	S	PFAM Appr-1-p processing	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,Macro
HKD1_k127_4755464_1	767817.Desgi_3508	2.933e-87	293.0	COG2304@1|root,COG2304@2|Bacteria,1TRPP@1239|Firmicutes,249HV@186801|Clostridia	186801|Clostridia	S	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	VWA
HKD1_k127_4760395_0	357809.Cphy_2132	2.149e-204	642.0	COG0474@1|root,COG0474@2|Bacteria,1UBI0@1239|Firmicutes,247T7@186801|Clostridia,221NB@1506553|Lachnoclostridium	186801|Clostridia	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_4760452_0	500632.CLONEX_02691	1.197e-92	310.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD1_k127_4760452_1	500632.CLONEX_02690	2.498e-43	162.0	COG0709@1|root,COG0709@2|Bacteria,1TQCJ@1239|Firmicutes,247NS@186801|Clostridia	186801|Clostridia	H	Synthesizes selenophosphate from selenide and ATP	selD	-	2.7.9.3	ko:K01008	ko00450,ko01100,map00450,map01100	-	R03595	RC00002,RC02878	ko00000,ko00001,ko01000,ko03016	-	-	-	AIRS,AIRS_C
HKD1_k127_4761824_5	552398.HMPREF0866_02372	2.263e-58	209.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,24C0U@186801|Clostridia,3WHKF@541000|Ruminococcaceae	186801|Clostridia	K	FCD	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_4761824_3	768706.Desor_2043	2.226e-104	350.0	COG5401@1|root,COG5401@2|Bacteria,1TQX6@1239|Firmicutes,249MF@186801|Clostridia,2612X@186807|Peptococcaceae	186801|Clostridia	S	PFAM Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HKD1_k127_4761824_4	1123009.AUID01000017_gene357	4.746e-100	332.0	COG1349@1|root,COG1349@2|Bacteria,1TSF8@1239|Firmicutes,25C4D@186801|Clostridia	186801|Clostridia	K	transcriptional regulator DeoR family	-	-	-	ko:K02081,ko:K03436	-	-	-	-	ko00000,ko03000	-	-	-	DeoRC,HTH_DeoR
HKD1_k127_4761824_0	1123009.AUID01000017_gene356	9.042e-201	633.0	COG3395@1|root,COG3395@2|Bacteria,1TPNP@1239|Firmicutes,24AJF@186801|Clostridia,26AGZ@186813|unclassified Clostridiales	186801|Clostridia	S	Putative nucleotide-binding of sugar-metabolising enzyme	-	-	2.7.1.219,2.7.1.220	ko:K22129	-	-	-	-	ko00000,ko01000	-	-	-	DUF1357_C,DUF1537
HKD1_k127_4761824_1	1123009.AUID01000017_gene355	7.357e-177	557.0	COG1995@1|root,COG1995@2|Bacteria,1TQGT@1239|Firmicutes,24A12@186801|Clostridia,26AQG@186813|unclassified Clostridiales	186801|Clostridia	H	Pyridoxal phosphate biosynthetic protein PdxA	pdxA	-	1.1.1.262,1.1.1.408,1.1.1.409	ko:K00097,ko:K22024	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD1_k127_4761824_2	1123009.AUID01000017_gene354	3.877e-126	407.0	COG2610@1|root,COG2610@2|Bacteria,1TQ14@1239|Firmicutes,248PQ@186801|Clostridia,26A6Y@186813|unclassified Clostridiales	186801|Clostridia	EG	GntP family permease	gntP	-	-	ko:K03299	-	-	-	-	ko00000,ko02000	2.A.8	-	-	GntP_permease
HKD1_k127_4762570_0	1304284.L21TH_1605	9.615e-156	501.0	COG0166@1|root,COG0166@2|Bacteria,1TP29@1239|Firmicutes,2487A@186801|Clostridia,36DWA@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the GPI family	pgi	-	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD1_k127_4762570_1	445335.CBN_1829	9.606e-90	309.0	COG2996@1|root,COG2996@2|Bacteria,1TQ1Z@1239|Firmicutes,2498C@186801|Clostridia,36EB0@31979|Clostridiaceae	186801|Clostridia	S	S1, RNA binding domain	cvfB	-	-	ko:K00243	-	-	-	-	ko00000	-	-	-	S1,S1_2
HKD1_k127_4763605_1	1033810.HLPCO_000274	4.361e-09	60.0	COG1873@1|root,COG1873@2|Bacteria	2|Bacteria	S	PRC-barrel domain	ylmC	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_4763605_0	1304284.L21TH_1327	3.173e-135	441.0	COG0743@1|root,COG0743@2|Bacteria,1TP1C@1239|Firmicutes,2483M@186801|Clostridia,36ECF@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS06420	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD1_k127_4764387_0	608506.COB47_1277	1.157e-17	86.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,42F4N@68295|Thermoanaerobacterales	186801|Clostridia	M	PFAM peptidase S11, D-alanyl-D-alanine carboxypeptidase	dacB2	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_4764387_1	1216932.CM240_1537	6.586e-05	51.0	COG3874@1|root,COG3874@2|Bacteria,1V6H7@1239|Firmicutes,24JJ5@186801|Clostridia,36JJX@31979|Clostridiaceae	186801|Clostridia	S	Sporulation protein YtfJ	ytfJ	-	-	-	-	-	-	-	-	-	-	-	Spore_YtfJ
HKD1_k127_4767071_1	1120746.CCNL01000014_gene2145	3.059e-88	294.0	COG0382@1|root,COG0382@2|Bacteria,2NP4W@2323|unclassified Bacteria	2|Bacteria	H	UbiA prenyltransferase family	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_4767071_0	1449050.JNLE01000005_gene4167	3.206e-263	820.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,36G19@31979|Clostridiaceae	186801|Clostridia	H	Belongs to the UbiD family	-	-	4.1.1.61,4.1.1.98	ko:K03182,ko:K16239	ko00130,ko00627,ko01100,ko01110,ko01120,map00130,map00627,map01100,map01110,map01120	M00117	R01238,R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_4767071_2	608506.COB47_0209	6.146e-18	85.0	2DR1Y@1|root,339TZ@2|Bacteria,1VK7M@1239|Firmicutes	1239|Firmicutes	S	Protein of unknown function (DUF3006)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3006
HKD1_k127_4767071_3	203119.Cthe_2752	3.992e-16	79.0	COG2333@1|root,COG2333@2|Bacteria,1TS9U@1239|Firmicutes,249VR@186801|Clostridia,3WIY7@541000|Ruminococcaceae	186801|Clostridia	J	Metallo-beta-lactamase domain protein	-	-	-	ko:K02238	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	Ada_Zn_binding,Lactamase_B
HKD1_k127_4768203_0	1120998.AUFC01000001_gene1882	6.023e-65	230.0	2B792@1|root,320BN@2|Bacteria,1V58V@1239|Firmicutes,24I68@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4768203_1	1033737.CAEV01000022_gene3294	1.207e-15	79.0	COG0534@1|root,COG0534@2|Bacteria,1TP6V@1239|Firmicutes,248EF@186801|Clostridia,36E0R@31979|Clostridiaceae	186801|Clostridia	V	Na driven multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_4768203_2	536233.CLO_2732	1.802e-10	63.0	COG0534@1|root,COG0534@2|Bacteria,1TP6V@1239|Firmicutes,248EF@186801|Clostridia,36E0R@31979|Clostridiaceae	186801|Clostridia	V	Na driven multidrug efflux pump	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_4772216_1	1304284.L21TH_0324	7.899e-54	194.0	COG0681@1|root,COG0681@2|Bacteria,1VB8H@1239|Firmicutes,25CN8@186801|Clostridia,36WYA@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the peptidase S26 family	lepB	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD1_k127_4772216_0	195103.CPF_2403	2.225e-148	484.0	COG2195@1|root,COG2195@2|Bacteria,1TQBS@1239|Firmicutes,24860@186801|Clostridia,36DNZ@31979|Clostridiaceae	186801|Clostridia	E	aminoacyl-histidine dipeptidase	pepD	-	-	ko:K01270	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4775195_0	509191.AEDB02000098_gene3517	1.651e-200	631.0	COG1132@1|root,COG1132@2|Bacteria,1TPTK@1239|Firmicutes,249W7@186801|Clostridia,3WN0P@541000|Ruminococcaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_477619_4	887929.HMP0721_0580	3.327e-25	117.0	COG0758@1|root,COG0758@2|Bacteria,1V4AI@1239|Firmicutes,24IFD@186801|Clostridia,25WFW@186806|Eubacteriaceae	186801|Clostridia	L	DNA recombination-mediator protein A	-	-	-	ko:K04096	-	-	-	-	ko00000	-	-	-	DNA_processg_A
HKD1_k127_477619_2	1121335.Clst_1051	2.777e-34	136.0	COG4770@1|root,COG4770@2|Bacteria,1UXGM@1239|Firmicutes,2595W@186801|Clostridia,3WQW7@541000|Ruminococcaceae	186801|Clostridia	I	Biotin carboxyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl
HKD1_k127_477619_0	1121289.JHVL01000048_gene899	2.576e-257	800.0	COG4799@1|root,COG4799@2|Bacteria,1TQCV@1239|Firmicutes,247WG@186801|Clostridia,36E1X@31979|Clostridiaceae	186801|Clostridia	I	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	yqjD	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD1_k127_477619_7	1408437.JNJN01000026_gene700	9.517e-05	52.0	2EGP1@1|root,33AF6@2|Bacteria,1VKE7@1239|Firmicutes,24WVS@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_477619_1	1341157.RF007C_11975	7.387e-136	447.0	COG3409@1|root,COG3409@2|Bacteria,1TS29@1239|Firmicutes,247SQ@186801|Clostridia,3WGZA@541000|Ruminococcaceae	186801|Clostridia	M	peptidoglycan binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,SpoIID
HKD1_k127_477619_3	1384066.JAGT01000001_gene1077	7.444e-28	119.0	COG3409@1|root,COG3409@2|Bacteria,1VI5G@1239|Firmicutes,24QHJ@186801|Clostridia,3WQEP@541000|Ruminococcaceae	186801|Clostridia	M	Putative peptidoglycan binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PG_binding_1
HKD1_k127_4779763_1	748449.Halha_0408	7.444e-67	233.0	2C2FW@1|root,32RAE@2|Bacteria,1V7TJ@1239|Firmicutes,24JU9@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4779763_0	1285586.H131_04889	1.066e-128	417.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4HECI@91061|Bacilli,3IVXM@400634|Lysinibacillus	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_4780167_0	1304284.L21TH_2120	2.277e-96	331.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia,36EIM@31979|Clostridiaceae	186801|Clostridia	J	ribonuclease, Rne Rng family	rng	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1,TRAM
HKD1_k127_4782589_1	1121430.JMLG01000008_gene1575	6.439e-15	76.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24BQ7@186801|Clostridia,26476@186807|Peptococcaceae	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Cu_amine_oxidN1,Peripla_BP_2
HKD1_k127_4782589_0	1304284.L21TH_2464	6.321e-138	450.0	COG0793@1|root,COG0793@2|Bacteria,1TPBI@1239|Firmicutes,248HZ@186801|Clostridia,36DGU@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD1_k127_4782589_2	56780.SYN_03595	0.0005311	42.0	COG1484@1|root,COG1484@2|Bacteria,1MVU2@1224|Proteobacteria,42PXQ@68525|delta/epsilon subdivisions,2WKHU@28221|Deltaproteobacteria	28221|Deltaproteobacteria	L	PFAM IstB domain protein ATP-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	IstB_IS21
HKD1_k127_4786252_2	545693.BMQ_1624	6.677e-07	52.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HADT@91061|Bacilli,1ZCKV@1386|Bacillus	91061|Bacilli	KT	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_12,HTH_8,PAS,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_4786252_1	1280689.AUJC01000011_gene1637	1.113e-31	129.0	COG1671@1|root,COG1671@2|Bacteria,1V9Z0@1239|Firmicutes,24HPW@186801|Clostridia,36J4K@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0178 family	-	-	-	ko:K09768	-	-	-	-	ko00000	-	-	-	DUF188
HKD1_k127_4786252_0	315749.Bcer98_0433	1.3e-99	336.0	COG0707@1|root,COG0707@2|Bacteria,1TR07@1239|Firmicutes,4HBKJ@91061|Bacilli,1ZQUQ@1386|Bacillus	91061|Bacilli	M	Processive glucosyltransferase involved in the biosynthesis of both the bilayer- and non-bilayer-forming membrane glucolipids. Is able to successively transfer up to three glucosyl residues to diacylglycerol (DAG), thereby catalyzing the formation of beta-monoglucosyl-DAG (3-O-(beta-D-glucopyranosyl)-1,2-diacyl- sn-glycerol), beta-diglucosyl-DAG (3-O-(beta-D-glucopyranosyl- beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn-glycerol) and beta- triglucosyl-DAG (3-O-(beta-D-glucopyranosyl-beta-(1- 6)-D- glucopyranosyl-beta-(1- 6)-D-glucopyranosyl)-1,2-diacyl-sn- glycerol). Beta-diglucosyl-DAG is the predominant glycolipid found in Bacillales and is also used as a membrane anchor for lipoteichoic acid (LTA)	ugtP	GO:0003674,GO:0003824,GO:0008194,GO:0016740,GO:0016757,GO:0016758,GO:0035251,GO:0046527,GO:0047228	2.4.1.315	ko:K03429	ko00561,ko01100,map00561,map01100	-	R02689,R04377	RC00005,RC00059	ko00000,ko00001,ko01000,ko01003	-	GT28	-	Glyco_tran_28_C,Glycos_transf_1,MGDG_synth
HKD1_k127_4786883_2	484770.UFO1_3915	1.025e-11	65.0	COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,4H3MQ@909932|Negativicutes	909932|Negativicutes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_4786883_0	1234679.BN424_2603	5.873e-55	202.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,4HCGA@91061|Bacilli,27FA7@186828|Carnobacteriaceae	91061|Bacilli	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_4786883_1	632518.Calow_1454	3.02e-15	76.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,42F6N@68295|Thermoanaerobacterales	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_4787167_1	935948.KE386495_gene1820	3.838e-14	78.0	COG1555@1|root,COG1555@2|Bacteria,1VA3W@1239|Firmicutes,24MQF@186801|Clostridia,42GEY@68295|Thermoanaerobacterales	186801|Clostridia	L	TIGRFAM competence protein ComEA helix-hairpin-helix	comEA	-	-	ko:K02237	-	M00429	-	-	ko00000,ko00002,ko02044	3.A.11.1,3.A.11.2	-	-	HHH_3,SLBB
HKD1_k127_4787167_0	1121289.JHVL01000002_gene2397	3.278e-106	359.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,36EWK@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacB	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_4792720_1	648885.KB316283_gene2918	6.26e-30	126.0	28HBI@1|root,2Z7NH@2|Bacteria,1QZQ9@1224|Proteobacteria,2TYRS@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF4241
HKD1_k127_4792720_0	1347392.CCEZ01000043_gene213	4.974e-60	211.0	COG1327@1|root,COG1327@2|Bacteria,1V3JA@1239|Firmicutes,24HFT@186801|Clostridia,36HY1@31979|Clostridiaceae	186801|Clostridia	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD1_k127_4792720_2	1286171.EAL2_808p02710	4.207e-06	49.0	COG0013@1|root,COG0013@2|Bacteria,1TSBZ@1239|Firmicutes,249VN@186801|Clostridia,25W97@186806|Eubacteriaceae	186801|Clostridia	J	Threonyl and Alanyl tRNA synthetase second additional domain	alaXL	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD1_k127_4793220_0	1304284.L21TH_2405	6.618e-102	344.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,36E94@31979|Clostridiaceae	186801|Clostridia	V	Permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_4793220_1	350688.Clos_2619	3.666e-51	183.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,36EK4@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_4794439_2	350688.Clos_2341	3.246e-26	110.0	COG0017@1|root,COG0017@2|Bacteria,1TP38@1239|Firmicutes,2484D@186801|Clostridia,36E04@31979|Clostridiaceae	186801|Clostridia	J	Asparaginyl-tRNA synthetase	asnS	-	6.1.1.22	ko:K01893	ko00970,map00970	M00359,M00360	R03648	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2,tRNA_anti-codon
HKD1_k127_4794439_1	1304284.L21TH_0677	3.465e-52	191.0	COG1564@1|root,COG1564@2|Bacteria,1VA0W@1239|Firmicutes,24NG6@186801|Clostridia,36J5Q@31979|Clostridiaceae	186801|Clostridia	H	thiamine pyrophosphokinase	thiN	-	2.7.6.2	ko:K00949	ko00730,ko01100,map00730,map01100	-	R00619	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TPK_B1_binding,TPK_catalytic
HKD1_k127_4794439_0	1304284.L21TH_0676	1.141e-88	297.0	COG0036@1|root,COG0036@2|Bacteria,1TQK8@1239|Firmicutes,248AR@186801|Clostridia,36EV9@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD1_k127_4794439_3	1392487.JIAD01000001_gene548	1.039e-22	99.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,25VS5@186806|Eubacteriaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
HKD1_k127_4813779_0	272562.CA_C1782	7.41e-289	897.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1TQ38@1239|Firmicutes,2484Z@186801|Clostridia,36E6X@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.5.1	ko:K01950	ko00760,ko01100,map00760,map01100	M00115	R00257	RC00010,RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD1_k127_4836957_0	350688.Clos_1201	1.233e-117	388.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,36ETV@31979|Clostridiaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	macB1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_4836957_1	536227.CcarbDRAFT_4281	1.44e-40	153.0	COG0122@1|root,COG0122@2|Bacteria,1V2ZM@1239|Firmicutes,248KP@186801|Clostridia,36IYP@31979|Clostridiaceae	186801|Clostridia	L	HhH-GPD superfamily base excision DNA repair protein	-	-	2.1.1.63,3.2.2.21	ko:K00567,ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD1_k127_4849016_0	1304284.L21TH_2379	1.367e-278	870.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,36DMT@31979|Clostridiaceae	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_4859090_7	1035196.HMPREF9998_01664	4.609e-40	151.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,25R29@186804|Peptostreptococcaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_4859090_0	665950.HMPREF1025_02053	1.495e-289	913.0	COG0249@1|root,COG0249@2|Bacteria,1TPRJ@1239|Firmicutes,248GI@186801|Clostridia,27IUI@186928|unclassified Lachnospiraceae	186801|Clostridia	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD1_k127_4859090_2	1128398.Curi_c15150	4.829e-189	601.0	COG0621@1|root,COG0621@2|Bacteria,1TNYN@1239|Firmicutes,2482Y@186801|Clostridia,267K9@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_4859090_1	1120998.AUFC01000019_gene284	7.073e-273	846.0	COG4108@1|root,COG4108@2|Bacteria,1TPYT@1239|Firmicutes,247X3@186801|Clostridia,3WDSH@538999|Clostridiales incertae sedis	186801|Clostridia	J	Class II release factor RF3, C-terminal domain	prfC	-	-	ko:K02837	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,RF3_C
HKD1_k127_4859090_4	1449050.JNLE01000003_gene2098	2.681e-136	438.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,247XS@186801|Clostridia,36E9K@31979|Clostridiaceae	186801|Clostridia	IQ	Dehydrogenase	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_4859090_6	913865.DOT_1376	2.292e-107	357.0	COG1924@1|root,COG1924@2|Bacteria,1TPU5@1239|Firmicutes,2481F@186801|Clostridia,260B5@186807|Peptococcaceae	186801|Clostridia	I	BadF BadG BcrA BcrD	-	-	-	-	-	-	-	-	-	-	-	-	BcrAD_BadFG
HKD1_k127_4859090_3	1321778.HMPREF1982_04582	4.145e-177	561.0	COG3581@1|root,COG3581@2|Bacteria,1TPPP@1239|Firmicutes,249C8@186801|Clostridia,26ASX@186813|unclassified Clostridiales	186801|Clostridia	I	PFAM CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2229
HKD1_k127_4859090_5	641107.CDLVIII_4776	6.981e-127	411.0	COG3580@1|root,COG3580@2|Bacteria,1TR03@1239|Firmicutes,24987@186801|Clostridia,36DX9@31979|Clostridiaceae	186801|Clostridia	I	CoA enzyme activase uncharacterised domain (DUF2229)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2229
HKD1_k127_4869756_1	742735.HMPREF9467_04282	2.076e-77	260.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,21XVE@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	grdB	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HKD1_k127_4869756_2	1511.CLOST_1113	5.865e-40	149.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,25R61@186804|Peptostreptococcaceae	186801|Clostridia	S	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB)	grdB	-	1.21.4.2,1.21.4.4	ko:K10672,ko:K21579	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HKD1_k127_4869756_0	865861.AZSU01000001_gene457	3.06e-147	472.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,36E0J@31979|Clostridiaceae	186801|Clostridia	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_4872609_0	1121289.JHVL01000009_gene1488	7.928e-174	551.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,36EFK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
HKD1_k127_4873643_0	1469948.JPNB01000001_gene426	1.387e-83	280.0	COG1464@1|root,COG1464@2|Bacteria,1TQAS@1239|Firmicutes,247WV@186801|Clostridia,36DGV@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the nlpA lipoprotein family	metQ	-	-	ko:K02073	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	Lipoprotein_9
HKD1_k127_4873643_1	552398.HMPREF0866_03036	1.223e-71	249.0	COG1802@1|root,COG1802@2|Bacteria,1V8HR@1239|Firmicutes,24JYB@186801|Clostridia	186801|Clostridia	K	FCD domain	-	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_487697_0	1121334.KB911066_gene1044	6.193e-87	289.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,3WHZI@541000|Ruminococcaceae	186801|Clostridia	P	phosphate transporter	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD1_k127_487697_2	1280692.AUJL01000036_gene352	4.459e-65	228.0	COG1392@1|root,COG1392@2|Bacteria,1UYRI@1239|Firmicutes,24BCU@186801|Clostridia,36DGM@31979|Clostridiaceae	186801|Clostridia	P	phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	PhoU_div
HKD1_k127_487697_1	1304284.L21TH_1830	1.011e-84	286.0	COG2344@1|root,COG2344@2|Bacteria,1TSMR@1239|Firmicutes,247RQ@186801|Clostridia,36EUI@31979|Clostridiaceae	186801|Clostridia	K	Modulates transcription in response to changes in cellular NADH NAD( ) redox state	rex	-	-	ko:K01926	-	-	-	-	ko00000,ko03000	-	-	-	CoA_binding,Put_DNA-bind_N
HKD1_k127_489566_1	994573.T472_0203965	5.084e-82	279.0	COG3284@1|root,COG3284@2|Bacteria,1VHQN@1239|Firmicutes,25EB0@186801|Clostridia,36UIY@31979|Clostridiaceae	186801|Clostridia	KQ	Sigma54 specific transcriptional regulator, Fis family	aorR	-	-	ko:K21405	-	-	-	-	ko00000,ko03000	-	-	-	GAF,HTH_8,PAS,PAS_8,PAS_9,Sigma54_activat
HKD1_k127_489566_0	555088.DealDRAFT_0977	1.635e-160	527.0	COG2199@1|root,COG3437@1|root,COG4191@1|root,COG2199@2|Bacteria,COG3437@2|Bacteria,COG4191@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,42KBX@68298|Syntrophomonadaceae	186801|Clostridia	T	metal-dependent phosphohydrolase HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5,PAS,PAS_3,PAS_4,PAS_9
HKD1_k127_490405_3	768706.Desor_1847	2.976e-05	46.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,248DM@186801|Clostridia,266Z5@186807|Peptococcaceae	186801|Clostridia	U	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD1_k127_490405_1	445971.ANASTE_01058	3.612e-18	88.0	COG0285@1|root,COG0285@2|Bacteria,1TPX5@1239|Firmicutes,247PC@186801|Clostridia,25V6Z@186806|Eubacteriaceae	186801|Clostridia	H	Folylpolyglutamate synthase	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_490405_0	1487921.DP68_03865	5.883e-197	621.0	COG1914@1|root,COG1914@2|Bacteria,1TPT1@1239|Firmicutes,248DM@186801|Clostridia,36F7Y@31979|Clostridiaceae	186801|Clostridia	P	H( )-stimulated, divalent metal cation uptake system	mntH	-	-	ko:K03322	-	-	-	-	ko00000,ko02000	2.A.55.2.6,2.A.55.3	-	-	Nramp
HKD1_k127_490405_2	1321778.HMPREF1982_00241	1.407e-17	83.0	COG1321@1|root,COG1321@2|Bacteria,1V3IS@1239|Firmicutes,25MWB@186801|Clostridia,26CFB@186813|unclassified Clostridiales	186801|Clostridia	K	Helix-turn-helix diphteria tox regulatory element	-	-	-	-	-	-	-	-	-	-	-	-	Fe_dep_repr_C,Fe_dep_repress
HKD1_k127_4913454_1	1120746.CCNL01000010_gene1129	3.501e-70	244.0	COG1360@1|root,COG1360@2|Bacteria,2NRCZ@2323|unclassified Bacteria	2|Bacteria	N	Membrane MotB of proton-channel complex MotA/MotB	-	-	-	ko:K02557	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02000,ko02035	1.A.30.1	-	-	MotB_plug,OmpA
HKD1_k127_4913454_0	1105031.HMPREF1141_1096	3.659e-89	301.0	COG1291@1|root,COG1291@2|Bacteria,1TRH1@1239|Firmicutes,24H4T@186801|Clostridia,36IBT@31979|Clostridiaceae	186801|Clostridia	N	MotA/TolQ/ExbB proton channel family	-	-	-	-	-	-	-	-	-	-	-	-	MotA_ExbB
HKD1_k127_4913688_2	1121324.CLIT_10c04100	2.685e-114	372.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,25QJ4@186804|Peptostreptococcaceae	186801|Clostridia	P	Psort location CytoplasmicMembrane, score	appF	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_4913688_0	1123009.AUID01000005_gene1619	1.044e-158	506.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,2689V@186813|unclassified Clostridiales	186801|Clostridia	EP	Oligopeptide/dipeptide transporter, C-terminal region	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_4913688_1	742738.HMPREF9460_02615	4.323e-135	442.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,267WJ@186813|unclassified Clostridiales	186801|Clostridia	EP	Psort location CytoplasmicMembrane, score 10.00	oppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD1_k127_4920224_1	1120998.AUFC01000023_gene2193	3.872e-22	97.0	COG2805@1|root,COG2805@2|Bacteria,1TQ5F@1239|Firmicutes,249H9@186801|Clostridia	186801|Clostridia	NU	twitching motility protein	pilT	-	-	ko:K02669	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSE
HKD1_k127_4920224_0	1121344.JHZO01000004_gene1350	1.462e-71	251.0	COG1305@1|root,COG1305@2|Bacteria,1TP7G@1239|Firmicutes,24BSB@186801|Clostridia,3WM58@541000|Ruminococcaceae	186801|Clostridia	E	Transglutaminase-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_4920253_1	457415.HMPREF1006_00688	2.735e-76	260.0	COG0183@1|root,COG0183@2|Bacteria,3TA5D@508458|Synergistetes	508458|Synergistetes	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_4920253_0	2754.EH55_09260	3.021e-163	523.0	COG1804@1|root,COG1804@2|Bacteria,3T9W8@508458|Synergistetes	508458|Synergistetes	C	PFAM L-carnitine dehydratase bile acid-inducible protein F	-	-	2.8.3.16,2.8.3.19	ko:K07749,ko:K18702	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD1_k127_4920253_2	2754.EH55_09255	9.744e-33	128.0	COG2185@1|root,COG2185@2|Bacteria,3TAYI@508458|Synergistetes	508458|Synergistetes	I	PFAM cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
HKD1_k127_4931476_0	1123009.AUID01000013_gene1745	1.944e-167	535.0	COG0025@1|root,COG0025@2|Bacteria,1UJT4@1239|Firmicutes,25F9G@186801|Clostridia,26CSP@186813|unclassified Clostridiales	186801|Clostridia	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_4931476_1	641107.CDLVIII_4573	3.095e-65	227.0	2E40Z@1|root,32YXS@2|Bacteria,1VHDW@1239|Firmicutes,24J44@186801|Clostridia,36J7H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_4931476_2	999413.HMPREF1094_03344	0.0001073	46.0	COG1638@1|root,COG1638@2|Bacteria,1TP3I@1239|Firmicutes,3VPKX@526524|Erysipelotrichia	526524|Erysipelotrichia	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_4935325_0	1292035.H476_2697	8.297e-147	474.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,25QQ2@186804|Peptostreptococcaceae	186801|Clostridia	S	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_4935325_1	1304284.L21TH_1345	1.04e-137	450.0	COG0612@1|root,COG0612@2|Bacteria,1TP5I@1239|Firmicutes,248HT@186801|Clostridia,36DH6@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the peptidase M16 family	ymxG	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD1_k127_4935325_2	1111134.HMPREF1253_1551	3.575e-59	207.0	COG0756@1|root,COG0756@2|Bacteria,1V6HX@1239|Firmicutes,24K3X@186801|Clostridia,22HHV@1570339|Peptoniphilaceae	186801|Clostridia	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD1_k127_4935325_3	1301100.HG529252_gene6236	1.643e-16	81.0	COG1873@1|root,COG1873@2|Bacteria,1VEJW@1239|Firmicutes	1239|Firmicutes	S	sporulation protein, YlmC YmxH	ymxH	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD1_k127_4953903_0	1128398.Curi_c16270	7.389e-33	141.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,267UY@186813|unclassified Clostridiales	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_4957845_1	1304284.L21TH_0977	8.08e-58	205.0	COG1161@1|root,COG1161@2|Bacteria,1TQGK@1239|Firmicutes,2490H@186801|Clostridia,36DQN@31979|Clostridiaceae	186801|Clostridia	S	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity	ylqF	-	-	ko:K14540	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1
HKD1_k127_4957845_0	1304284.L21TH_0976	1.314e-88	296.0	COG0164@1|root,COG0164@2|Bacteria,1V1D6@1239|Firmicutes,248IT@186801|Clostridia,36DHX@31979|Clostridiaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD1_k127_4963958_0	1196322.A370_00449	2.524e-167	535.0	COG2211@1|root,COG2211@2|Bacteria,1UKKD@1239|Firmicutes,25GE3@186801|Clostridia,36V4C@31979|Clostridiaceae	186801|Clostridia	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_4965780_0	994573.T472_0208345	6.284e-137	442.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,36ER4@31979|Clostridiaceae	186801|Clostridia	D	MutL protein	mutL2	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD1_k127_4965780_1	1321778.HMPREF1982_00326	1.589e-19	88.0	COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,24HGC@186801|Clostridia	186801|Clostridia	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD1_k127_4965877_1	632245.CLP_4250	1.451e-34	140.0	COG4129@1|root,COG4129@2|Bacteria,1UYPC@1239|Firmicutes,24DAE@186801|Clostridia,36H18@31979|Clostridiaceae	186801|Clostridia	S	Fusaric acid resistance protein-like	-	-	-	-	-	-	-	-	-	-	-	-	ArAE_1,FUSC_2
HKD1_k127_4965877_2	545694.TREPR_3708	5.453e-27	111.0	2E3FD@1|root,32YE7@2|Bacteria,2J8T6@203691|Spirochaetes	203691|Spirochaetes	S	TSCPD domain	-	-	-	-	-	-	-	-	-	-	-	-	TSCPD
HKD1_k127_4965877_3	1408303.JNJJ01000082_gene2014	1.917e-07	56.0	2E9CH@1|root,333K6@2|Bacteria,1VG2H@1239|Firmicutes,4HNZC@91061|Bacilli,1ZIUF@1386|Bacillus	91061|Bacilli	S	Sigma-K factor-processing regulatory protein BofA	bofA	-	-	ko:K06317	-	-	-	-	ko00000	-	-	-	BofA
HKD1_k127_4965877_0	1304284.L21TH_0863	9.949e-121	403.0	COG1982@1|root,COG1982@2|Bacteria,1TNZ9@1239|Firmicutes,247RA@186801|Clostridia,36DPH@31979|Clostridiaceae	186801|Clostridia	E	Orn Lys Arg decarboxylase major	speA	-	4.1.1.18	ko:K01582	ko00310,ko00960,ko01100,ko01110,map00310,map00960,map01100,map01110	-	R00462	RC00299	ko00000,ko00001,ko01000	-	-	-	OKR_DC_1,OKR_DC_1_C
HKD1_k127_4966058_1	720554.Clocl_3817	1.028e-91	303.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,3WIKQ@541000|Ruminococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DDE_Tnp_1_6,DUF772
HKD1_k127_4966058_0	1487921.DP68_16895	8.525e-147	471.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD1_k127_4966058_2	1536775.H70737_17370	1.417e-54	194.0	COG5646@1|root,COG5646@2|Bacteria,1V6QB@1239|Firmicutes,4HINV@91061|Bacilli,26YRN@186822|Paenibacillaceae	91061|Bacilli	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD1_k127_4966168_1	1161902.HMPREF0378_1525	5.826e-76	260.0	COG1435@1|root,COG1435@2|Bacteria,1TRVM@1239|Firmicutes,24CVH@186801|Clostridia,3WDKV@538999|Clostridiales incertae sedis	186801|Clostridia	F	Thymidine kinase	tdk	-	2.7.1.21	ko:K00857	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01567,R02099,R08233	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	TK
HKD1_k127_4966168_0	1347392.CCEZ01000075_gene3079	1.029e-151	496.0	COG1574@1|root,COG1574@2|Bacteria,1TQ6G@1239|Firmicutes,24A5F@186801|Clostridia,36DJ1@31979|Clostridiaceae	186801|Clostridia	S	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD1_k127_4966874_0	370438.PTH_1885	2.233e-73	252.0	COG0714@1|root,COG1067@1|root,COG0714@2|Bacteria,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,260R2@186807|Peptococcaceae	186801|Clostridia	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD1_k127_4968253_0	445971.ANASTE_01819	8.536e-72	249.0	COG3619@1|root,COG3619@2|Bacteria,1V1VQ@1239|Firmicutes,24DUE@186801|Clostridia,25WCR@186806|Eubacteriaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1275
HKD1_k127_4970347_0	1405498.SSIM_09420	1.877e-131	434.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,4HB12@91061|Bacilli,4GX0T@90964|Staphylococcaceae	91061|Bacilli	L	ATP-dependent DNA helicase	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_4974264_1	1449342.JQMR01000001_gene1587	9.323e-53	191.0	COG1802@1|root,COG1802@2|Bacteria,1TSV2@1239|Firmicutes,4HATG@91061|Bacilli,27GIB@186828|Carnobacteriaceae	91061|Bacilli	K	FCD	citR	-	-	-	-	-	-	-	-	-	-	-	FCD,GntR
HKD1_k127_4974264_0	1449343.JQLQ01000002_gene623	3.114e-53	194.0	COG1767@1|root,COG1767@2|Bacteria,1TQGQ@1239|Firmicutes,4HGCS@91061|Bacilli,27HD4@186828|Carnobacteriaceae	91061|Bacilli	H	ATP:dephospho-CoA triphosphoribosyl transferase	citG	-	2.4.2.52	ko:K05966	ko02020,map02020	-	R09675	RC00049,RC00063	ko00000,ko00001,ko01000	-	-	-	CitG
HKD1_k127_4974514_1	1304284.L21TH_2444	1.249e-118	392.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,36ES8@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	iHN637.CLJU_RS15830	Ala_racemase_C,Ala_racemase_N
HKD1_k127_4974514_0	642492.Clole_2568	3.521e-199	625.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia	186801|Clostridia	S	Abc transporter	yfmM	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_4975216_1	1294142.CINTURNW_0693	5.545e-63	218.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_4975216_0	1443125.Z962_00035	2.674e-69	242.0	COG0340@1|root,COG1654@1|root,COG0340@2|Bacteria,COG1654@2|Bacteria,1TQCU@1239|Firmicutes,248CK@186801|Clostridia,36F7S@31979|Clostridiaceae	186801|Clostridia	HK	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a repressor	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,HTH_11
HKD1_k127_4977450_1	879308.HMPREF9130_1073	1.358e-36	142.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,22H7X@1570339|Peptoniphilaceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02029,ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	BPD_transp_1,SBP_bac_3
HKD1_k127_4977450_0	1123009.AUID01000007_gene678	2.489e-91	307.0	COG0834@1|root,COG0834@2|Bacteria,1TQNR@1239|Firmicutes,249Y5@186801|Clostridia,2693C@186813|unclassified Clostridiales	186801|Clostridia	ET	Bacterial periplasmic substrate-binding proteins	fliY1	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_4977450_2	1291050.JAGE01000001_gene1238	7.301e-34	133.0	COG0662@1|root,COG0662@2|Bacteria,1VEEQ@1239|Firmicutes,24JQ9@186801|Clostridia	186801|Clostridia	G	Cupin domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD1_k127_4979109_1	1449050.JNLE01000005_gene4921	1.236e-40	151.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,36E89@31979|Clostridiaceae	186801|Clostridia	E	ABC transporter	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD1_k127_4979109_0	1449050.JNLE01000005_gene4920	6.775e-145	464.0	COG0834@1|root,COG0834@2|Bacteria,1TT11@1239|Firmicutes,249IK@186801|Clostridia,36FAV@31979|Clostridiaceae	186801|Clostridia	ET	extracellular solute-binding protein, family 3	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_4979769_1	1408287.AXUR01000020_gene456	2.568e-45	170.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	siaP	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_4979769_0	864565.HMPREF0379_0728	2.407e-111	365.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,25S7G@186804|Peptostreptococcaceae	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM,DctQ
HKD1_k127_4981861_0	293826.Amet_2979	1.013e-118	396.0	COG5000@1|root,COG5000@2|Bacteria,1V3IT@1239|Firmicutes,249GI@186801|Clostridia,36FPA@31979|Clostridiaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_4983508_0	1230342.CTM_09551	5.298e-168	542.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
HKD1_k127_4988422_0	720554.Clocl_4123	1.289e-100	336.0	COG0614@1|root,COG0614@2|Bacteria,1UNE3@1239|Firmicutes,24AKE@186801|Clostridia,3WIUG@541000|Ruminococcaceae	186801|Clostridia	P	Periplasmic binding protein	btuF	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_4988422_1	509191.AEDB02000051_gene1343	1.919e-56	202.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WI3U@541000|Ruminococcaceae	186801|Clostridia	P	FecCD transport family	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_5004190_0	272562.CA_C3320	6.135e-161	516.0	COG3170@1|root,COG3170@2|Bacteria,1TR7V@1239|Firmicutes,247XU@186801|Clostridia,36E8Q@31979|Clostridiaceae	186801|Clostridia	NU	Putative amidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Amidase_6
HKD1_k127_5006500_3	1120998.AUFC01000006_gene914	2.455e-102	338.0	COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,3WCX3@538999|Clostridiales incertae sedis	186801|Clostridia	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18410	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
HKD1_k127_5006500_1	1410668.JNKC01000002_gene2100	1.973e-120	394.0	COG1879@1|root,COG1879@2|Bacteria,1TQ1B@1239|Firmicutes,247K8@186801|Clostridia,36DBX@31979|Clostridiaceae	186801|Clostridia	G	PFAM periplasmic binding protein	rbsB	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD1_k127_5006500_0	1410668.JNKC01000002_gene2099	6.482e-145	464.0	COG1172@1|root,COG1172@2|Bacteria,1TP72@1239|Firmicutes,249FA@186801|Clostridia,36DTM@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the binding-protein-dependent transport system permease family	rbsC	-	-	ko:K10440	ko02010,map02010	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	BPD_transp_2
HKD1_k127_5006500_2	1410668.JNKC01000002_gene2098	1.738e-103	341.0	COG1129@1|root,COG1129@2|Bacteria,1TP6I@1239|Firmicutes,247II@186801|Clostridia,36DME@31979|Clostridiaceae	186801|Clostridia	P	import. Responsible for energy coupling to the transport system	rbsA	-	3.6.3.17	ko:K10441,ko:K10542	ko02010,map02010	M00212,M00214	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19,3.A.1.2.3	-	-	ABC_tran
HKD1_k127_5014408_0	1449335.JQLG01000004_gene521	2.265e-143	459.0	COG2252@1|root,COG2252@2|Bacteria,1TQC6@1239|Firmicutes,4HANG@91061|Bacilli,27FF8@186828|Carnobacteriaceae	91061|Bacilli	S	Permease family	XK27_07275	-	-	ko:K06901	-	-	-	-	ko00000,ko02000	2.A.1.40	-	-	Xan_ur_permease
HKD1_k127_5021984_0	1209989.TepiRe1_2006	7.051e-99	331.0	COG2203@1|root,COG3829@1|root,COG2203@2|Bacteria,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,42F02@68295|Thermoanaerobacterales	186801|Clostridia	K	transcriptional regulator	-	-	-	ko:K03721	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_8,Sigma54_activat
HKD1_k127_5021984_1	767817.Desgi_3040	1.111e-55	207.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,260NJ@186807|Peptococcaceae	186801|Clostridia	KT	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_8,PAS,PAS_9,Sigma54_activat,SpoVT_C
HKD1_k127_5028158_1	1123009.AUID01000004_gene1512	3.999e-39	146.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,26AYC@186813|unclassified Clostridiales	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_5028158_0	768706.Desor_4409	3.238e-308	952.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,260MU@186807|Peptococcaceae	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_10,Fer4_6,Fer4_9,POR_N,TPP_enzyme_C
HKD1_k127_5029383_0	1304284.L21TH_1094	0.0	1238.0	COG0587@1|root,COG0587@2|Bacteria,1TPYG@1239|Firmicutes,247U0@186801|Clostridia,36DHP@31979|Clostridiaceae	186801|Clostridia	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337,ko:K14162	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD1_k127_5029640_1	1121289.JHVL01000030_gene407	1.903e-32	131.0	COG0772@1|root,COG0772@2|Bacteria,1TPT7@1239|Firmicutes,24894@186801|Clostridia,36EE6@31979|Clostridiaceae	186801|Clostridia	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD1_k127_5029640_0	1304284.L21TH_0613	3.966e-67	234.0	COG0771@1|root,COG0771@2|Bacteria,1TQ3P@1239|Firmicutes,248GS@186801|Clostridia,36DUY@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD1_k127_5036886_1	1120746.CCNL01000010_gene1467	1.234e-25	110.0	COG1815@1|root,COG1815@2|Bacteria	2|Bacteria	N	bacterial-type flagellum-dependent cell motility	flgB	GO:0001539,GO:0005575,GO:0005623,GO:0006928,GO:0008150,GO:0009288,GO:0009424,GO:0009425,GO:0009987,GO:0040011,GO:0042995,GO:0043226,GO:0043228,GO:0044422,GO:0044461,GO:0044463,GO:0044464,GO:0048870,GO:0051179,GO:0051674,GO:0071973,GO:0071978,GO:0097588	-	ko:K02387,ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod
HKD1_k127_5036886_0	1304866.K413DRAFT_0042	3.362e-52	188.0	COG1558@1|root,COG1558@2|Bacteria,1V6NB@1239|Firmicutes,24JJW@186801|Clostridia,36IS4@31979|Clostridiaceae	186801|Clostridia	N	Belongs to the flagella basal body rod proteins family	flgC	-	-	ko:K02388	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	Flg_bb_rod,Flg_bbr_C
HKD1_k127_5041251_1	1304284.L21TH_1585	2.787e-45	179.0	COG0860@1|root,COG0860@2|Bacteria,1TSFS@1239|Firmicutes,2488U@186801|Clostridia,36F21@31979|Clostridiaceae	186801|Clostridia	M	stage II sporulation protein P	spoIIP	-	-	ko:K06385	-	-	-	-	ko00000	-	-	-	SpoIIP
HKD1_k127_5041251_0	1304284.L21TH_1372	2.538e-130	419.0	COG0481@1|root,COG0481@2|Bacteria,1TP0G@1239|Firmicutes,247V8@186801|Clostridia,36EZX@31979|Clostridiaceae	186801|Clostridia	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD1_k127_5041357_1	1127692.HMPREF9075_01545	5.161e-20	105.0	COG5263@1|root,COG5263@2|Bacteria,4NJ6B@976|Bacteroidetes,1HX7Q@117743|Flavobacteriia,1EQ9N@1016|Capnocytophaga	976|Bacteroidetes	S	WG containing repeat	-	-	-	-	-	-	-	-	-	-	-	-	WG_beta_rep
HKD1_k127_5041357_0	1408437.JNJN01000034_gene2221	2.605e-24	119.0	COG1621@1|root,COG5492@1|root,COG1621@2|Bacteria,COG5492@2|Bacteria,1VGM4@1239|Firmicutes,24QFQ@186801|Clostridia	186801|Clostridia	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_5043675_1	1121289.JHVL01000044_gene1580	4.728e-39	147.0	COG0776@1|root,COG0776@2|Bacteria,1V9XQ@1239|Firmicutes,24MM0@186801|Clostridia,36KID@31979|Clostridiaceae	186801|Clostridia	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	hup	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD1_k127_5043675_0	1304284.L21TH_1647	1.124e-149	487.0	COG1694@1|root,COG3956@2|Bacteria,1TPK1@1239|Firmicutes,247XM@186801|Clostridia,36E9N@31979|Clostridiaceae	186801|Clostridia	S	MazG family	mazG	-	3.6.1.66	ko:K02428,ko:K02499	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000,ko03036	-	-	-	MazG,TP_methylase
HKD1_k127_5044114_0	865861.AZSU01000002_gene2717	3.441e-152	513.0	COG0457@1|root,COG1672@1|root,COG3629@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,COG3629@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia,36DWM@31979|Clostridiaceae	186801|Clostridia	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
HKD1_k127_5044114_1	768704.Desmer_2152	2.009e-79	275.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_5047787_2	1297617.JPJD01000035_gene643	6.729e-90	300.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,269ZR@186813|unclassified Clostridiales	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_5047787_0	1297617.JPJD01000035_gene644	4.566e-147	472.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,26AUJ@186813|unclassified Clostridiales	186801|Clostridia	P	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_5047787_1	1297617.JPJD01000035_gene645	1.017e-145	468.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,26ABN@186813|unclassified Clostridiales	186801|Clostridia	E	Oligopeptide/dipeptide transporter, C-terminal region	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_5047787_3	1499683.CCFF01000017_gene2249	1.886e-35	138.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,2489D@186801|Clostridia,36FMI@31979|Clostridiaceae	186801|Clostridia	E	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_5068121_0	1304284.L21TH_0079	2.745e-166	539.0	COG1057@1|root,COG1057@2|Bacteria,1TQVJ@1239|Firmicutes,249M0@186801|Clostridia,36DM4@31979|Clostridiaceae	186801|Clostridia	H	Cytidylyltransferase-like	-	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_like
HKD1_k127_5073074_0	641107.CDLVIII_4733	1.542e-67	235.0	28PHV@1|root,2ZC86@2|Bacteria,1VBR0@1239|Firmicutes,24FVU@186801|Clostridia,36IC6@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5073074_1	1121887.AUDK01000007_gene1684	0.0005135	50.0	2AEQA@1|root,314KU@2|Bacteria,4PJ85@976|Bacteroidetes,1ICT3@117743|Flavobacteriia,2NUK1@237|Flavobacterium	976|Bacteroidetes	P	Ion channel	-	-	-	ko:K10716	-	-	-	-	ko00000,ko02000	1.A.1.1,1.A.1.13,1.A.1.17,1.A.1.24,1.A.1.25,1.A.1.6	-	-	Ion_trans_2
HKD1_k127_5079758_0	511680.BUTYVIB_00389	1.508e-143	459.0	COG0065@1|root,COG0065@2|Bacteria,1TPE5@1239|Firmicutes,2484F@186801|Clostridia,4BWUD@830|Butyrivibrio	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuC	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01703,ko:K20452	ko00290,ko00660,ko00760,ko00966,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map00966,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R08620,R08624,R08628,R08634,R08641,R08645,R10170	RC00497,RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS04465	Aconitase
HKD1_k127_5079758_1	1120998.AUFC01000019_gene270	5.303e-75	254.0	COG0066@1|root,COG0066@2|Bacteria,1V1I6@1239|Firmicutes,24FUI@186801|Clostridia,3WD25@538999|Clostridiales incertae sedis	186801|Clostridia	E	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate	leuD	-	4.2.1.33,4.2.1.35,4.2.1.85	ko:K01704,ko:K20453	ko00290,ko00660,ko00760,ko01100,ko01110,ko01120,ko01210,ko01230,map00290,map00660,map00760,map01100,map01110,map01120,map01210,map01230	M00432,M00535	R03069,R03896,R03898,R03968,R04001,R10170	RC00843,RC00976,RC00977,RC01041,RC01046,RC03072	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase_C
HKD1_k127_5079758_2	1414720.CBYM010000029_gene1726	2.142e-12	68.0	COG0473@1|root,COG0473@2|Bacteria,1TPEM@1239|Firmicutes,24A63@186801|Clostridia,36E5F@31979|Clostridiaceae	186801|Clostridia	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_5087366_2	1121289.JHVL01000003_gene2282	2.957e-33	132.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,36ETW@31979|Clostridiaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
HKD1_k127_5087366_0	1304284.L21TH_0674	1.579e-176	574.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_5087366_1	857293.CAAU_2103	3.986e-36	141.0	COG0631@1|root,COG0631@2|Bacteria,1V6K5@1239|Firmicutes,24JD4@186801|Clostridia,36F03@31979|Clostridiaceae	186801|Clostridia	T	Phosphatase	stp	-	3.1.3.16	ko:K20074	-	-	-	-	ko00000,ko01000,ko01009	-	-	-	PP2C,PP2C_2
HKD1_k127_5092014_4	386415.NT01CX_1776	2.056e-106	353.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,36F97@31979|Clostridiaceae	186801|Clostridia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pgm	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_5092014_3	318464.IO99_08400	2.716e-132	426.0	COG1210@1|root,COG1210@2|Bacteria,1TQ24@1239|Firmicutes,25E5A@186801|Clostridia,36EIH@31979|Clostridiaceae	186801|Clostridia	M	UTP-glucose-1-phosphate uridylyltransferase	galU	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS02205	NTP_transferase
HKD1_k127_5092014_1	1304284.L21TH_1225	4.84e-164	522.0	COG1077@1|root,COG1077@2|Bacteria,1TP51@1239|Firmicutes,247RG@186801|Clostridia,36DUP@31979|Clostridiaceae	186801|Clostridia	D	Cell shape determining protein, MreB Mrl family	mbl	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD1_k127_5092014_2	1280681.AUJZ01000007_gene1665	1.31e-154	497.0	COG0462@1|root,COG0462@2|Bacteria,1TQ6Q@1239|Firmicutes,248ZN@186801|Clostridia,4BW82@830|Butyrivibrio	186801|Clostridia	EF	Phosphoribosyl synthetase-associated domain	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran,Pribosyltran_N
HKD1_k127_5092014_5	1120953.AUBH01000001_gene908	6.218e-71	255.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,1RP53@1236|Gammaproteobacteria,466MR@72275|Alteromonadaceae	1236|Gammaproteobacteria	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD1_k127_5092014_0	1123009.AUID01000015_gene2044	1.689e-185	588.0	COG1448@1|root,COG1448@2|Bacteria,1TRJV@1239|Firmicutes,24BZV@186801|Clostridia,26A3W@186813|unclassified Clostridiales	186801|Clostridia	E	Aminotransferase class I and II	-	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD1_k127_5092014_6	1120746.CCNL01000010_gene1128	4.349e-19	89.0	COG0534@1|root,COG0534@2|Bacteria,2NR89@2323|unclassified Bacteria	2|Bacteria	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_5097759_1	1304284.L21TH_1288	3.384e-35	138.0	COG0524@1|root,COG1522@1|root,COG0524@2|Bacteria,COG1522@2|Bacteria,1TQR4@1239|Firmicutes,24AUP@186801|Clostridia,36F1Z@31979|Clostridiaceae	186801|Clostridia	G	hmm pf00294	rbsK	-	2.7.1.15,2.7.1.83	ko:K00852,ko:K16328	ko00030,ko00240,map00030,map00240	-	R01051,R02750,R03315	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	HTH_24,PfkB
HKD1_k127_5097759_0	332101.JIBU02000043_gene1519	9.465e-159	504.0	COG2313@1|root,COG2313@2|Bacteria,1TR5J@1239|Firmicutes,247J8@186801|Clostridia,36F77@31979|Clostridiaceae	186801|Clostridia	Q	Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway	psuG	-	4.2.1.70	ko:K16329	ko00240,map00240	-	R01055	RC00432,RC00433	ko00000,ko00001,ko01000	-	-	-	Indigoidine_A
HKD1_k127_5103704_0	357809.Cphy_0614	5.028e-87	299.0	COG0840@1|root,COG0840@2|Bacteria,1TRIC@1239|Firmicutes,24BC0@186801|Clostridia	186801|Clostridia	NT	PFAM Methyl-accepting chemotaxis protein (MCP) signaling domain	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CZB,MCPsignal
HKD1_k127_5107684_0	545243.BAEV01000077_gene3015	4.589e-43	166.0	COG5001@1|root,COG5001@2|Bacteria,1TP8V@1239|Firmicutes,247PX@186801|Clostridia,36E1W@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_sub_bind,EAL,GGDEF,PAS_3
HKD1_k127_5107684_1	203119.Cthe_0805	6.459e-35	135.0	COG0745@1|root,COG0745@2|Bacteria,1V774@1239|Firmicutes,24JS3@186801|Clostridia,3WJRP@541000|Ruminococcaceae	186801|Clostridia	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_5107684_4	536227.CcarbDRAFT_0205	1.789e-07	52.0	COG0745@1|root,COG0745@2|Bacteria,1V774@1239|Firmicutes,24JS3@186801|Clostridia,36JUR@31979|Clostridiaceae	186801|Clostridia	KT	response regulator, receiver	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_5107684_3	398512.JQKC01000019_gene3406	3.918e-27	116.0	COG1871@1|root,COG1871@2|Bacteria,1VBH2@1239|Firmicutes,24NIW@186801|Clostridia,3WQ0V@541000|Ruminococcaceae	186801|Clostridia	NT	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis	cheD1	-	3.5.1.44	ko:K03411	ko02030,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheD
HKD1_k127_5107684_2	1345695.CLSA_c24150	2.863e-28	115.0	COG2201@1|root,COG2201@2|Bacteria,1TRHC@1239|Firmicutes,249FD@186801|Clostridia,36EIW@31979|Clostridiaceae	186801|Clostridia	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD1_k127_5107937_1	1227360.C176_07162	6.668e-19	95.0	COG2866@1|root,COG2866@2|Bacteria,1TP3K@1239|Firmicutes,4HAHN@91061|Bacilli,26DC4@186818|Planococcaceae	91061|Bacilli	E	Zinc carboxypeptidase	-	-	3.4.19.11	ko:K01308	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M14
HKD1_k127_5107937_0	994573.T472_0217940	3.54e-147	474.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,PAS_8,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_5110402_0	350688.Clos_0436	1.067e-226	707.0	COG1884@1|root,COG1884@2|Bacteria,1TQAD@1239|Firmicutes,24BDK@186801|Clostridia,36H9W@31979|Clostridiaceae	186801|Clostridia	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847,ko:K01848	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	MM_CoA_mutase
HKD1_k127_5110402_5	865861.AZSU01000007_gene1073	5.725e-68	233.0	COG2185@1|root,COG2185@2|Bacteria,1V3QN@1239|Firmicutes,24HAR@186801|Clostridia,36J94@31979|Clostridiaceae	186801|Clostridia	I	B12 binding domain	-	-	5.4.99.2	ko:K01849	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00375,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD1_k127_5110402_1	865861.AZSU01000007_gene1072	2.458e-113	373.0	COG1703@1|root,COG1703@2|Bacteria,1TQT4@1239|Firmicutes,24944@186801|Clostridia,36G13@31979|Clostridiaceae	186801|Clostridia	E	ArgK protein	argK	-	-	ko:K07588	-	-	-	-	ko00000,ko01000	-	-	-	ArgK
HKD1_k127_5110402_6	1121289.JHVL01000048_gene898	3.703e-66	227.0	COG0346@1|root,COG0346@2|Bacteria,1V6SC@1239|Firmicutes,24HPI@186801|Clostridia,36J72@31979|Clostridiaceae	186801|Clostridia	E	Glyoxalase-like domain	mce	-	4.4.1.5,5.1.99.1	ko:K01759,ko:K05606	ko00280,ko00620,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00620,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02530,R02765,R09979	RC00004,RC00740,RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD1_k127_5110402_8	1304284.L21TH_1307	5.382e-43	160.0	COG1694@1|root,COG1694@2|Bacteria,1VBGH@1239|Firmicutes,24JEF@186801|Clostridia,36IV1@31979|Clostridiaceae	186801|Clostridia	S	Mazg nucleotide pyrophosphohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5110402_9	1121289.JHVL01000013_gene1659	2.14e-36	143.0	2E0BG@1|root,32VYP@2|Bacteria,1VD9B@1239|Firmicutes,24PIR@186801|Clostridia,36MBP@31979|Clostridiaceae	186801|Clostridia	S	PrcB C-terminal	-	-	-	-	-	-	-	-	-	-	-	-	PrcB_C
HKD1_k127_5110402_3	580327.Tthe_0620	6.117e-85	288.0	COG2884@1|root,COG2884@2|Bacteria,1TP58@1239|Firmicutes,248HW@186801|Clostridia,42EW3@68295|Thermoanaerobacterales	186801|Clostridia	D	TIGRFAM Cell division ATP-binding protein FtsE	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD1_k127_5110402_2	1304284.L21TH_2462	1.726e-90	306.0	COG2177@1|root,COG2177@2|Bacteria,1TPND@1239|Firmicutes,24AA6@186801|Clostridia,36EH4@31979|Clostridiaceae	186801|Clostridia	D	Part of the ABC transporter FtsEX involved in asymmetric cellular division facilitating the initiation of sporulation	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD1_k127_5110402_4	1304284.L21TH_2463	1.452e-78	276.0	COG4942@1|root,COG4942@2|Bacteria,1TQ5I@1239|Firmicutes,248ZG@186801|Clostridia,36FVZ@31979|Clostridiaceae	186801|Clostridia	D	Peptidase, M23	-	-	-	ko:K21471	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD1_k127_5110402_7	1304284.L21TH_1022	8.563e-52	189.0	COG0465@1|root,COG0465@2|Bacteria,1TRV4@1239|Firmicutes,24C3E@186801|Clostridia,36FPW@31979|Clostridiaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	-	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,Peptidase_M41
HKD1_k127_5116962_0	1304284.L21TH_2354	2.424e-157	502.0	COG0332@1|root,COG0332@2|Bacteria,1TQSB@1239|Firmicutes,2499C@186801|Clostridia,36FF2@31979|Clostridiaceae	186801|Clostridia	I	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III	grdC	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K21577	-	-	-	-	ko00000,ko01000	-	-	-	ACP_syn_III
HKD1_k127_5116962_1	1007096.BAGW01000017_gene842	1.233e-54	192.0	2AE14@1|root,313TT@2|Bacteria,1V6GX@1239|Firmicutes,24K4C@186801|Clostridia	186801|Clostridia	C	In the first step of glycine, betaine and sarcosine reductases, the substrate is bound to component PB via a Schiff base intermediate. Then the PB-activated substrate is nucleophilically attacked by the selenol anion of component PA to transform it to a carboxymethylated selenoether and the respective amine. By action of component PC, acetyl phosphate is formed, leaving component PA in its oxidized state. Finally component PA becomes reduced by the thioredoxin system to start a new catalytic cycle of reductive deamination	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
HKD1_k127_5116962_3	742765.HMPREF9457_03825	1.268e-16	79.0	2DR3E@1|root,33A02@2|Bacteria,1VKEX@1239|Firmicutes,24UH8@186801|Clostridia	186801|Clostridia	S	Glycine sarcosine betaine reductase complex	grdA	-	1.21.4.2,1.21.4.3,1.21.4.4	ko:K10670	-	-	-	-	ko00000,ko01000	-	-	-	GRDA
HKD1_k127_5116962_2	1232452.BAIB02000006_gene1316	1.337e-50	181.0	COG3118@1|root,COG3118@2|Bacteria,1UHX3@1239|Firmicutes,24JPM@186801|Clostridia,26BYV@186813|unclassified Clostridiales	186801|Clostridia	O	Thioredoxin	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_5117941_4	941449.dsx2_2015	6.157e-08	55.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,42MV7@68525|delta/epsilon subdivisions,2WJTU@28221|Deltaproteobacteria,2M8RD@213115|Desulfovibrionales	28221|Deltaproteobacteria	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD1_k127_5117941_2	1128398.Curi_c15530	7.148e-69	243.0	COG0130@1|root,COG0130@2|Bacteria,1TP9Y@1239|Firmicutes,24B46@186801|Clostridia,2689N@186813|unclassified Clostridiales	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB-C_2,TruB_C_2,TruB_N
HKD1_k127_5117941_1	1347392.CCEZ01000043_gene362	4.799e-69	246.0	COG0618@1|root,COG0618@2|Bacteria,1TPXX@1239|Firmicutes,248R3@186801|Clostridia,36DFF@31979|Clostridiaceae	186801|Clostridia	S	domain protein	nrnA	-	3.1.13.3,3.1.3.7	ko:K06881	ko00920,ko01100,ko01120,map00920,map01100,map01120	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD1_k127_5117941_3	1499689.CCNN01000007_gene1335	1.698e-31	128.0	COG0858@1|root,COG0858@2|Bacteria,1VA0P@1239|Firmicutes,24MPB@186801|Clostridia,36JIF@31979|Clostridiaceae	186801|Clostridia	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD1_k127_5117941_0	1121289.JHVL01000003_gene2178	1.126e-204	645.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,36EJE@31979|Clostridiaceae	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD1_k127_5119028_1	1347392.CCEZ01000009_gene2311	1.619e-70	242.0	COG0796@1|root,COG0796@2|Bacteria,1TPPR@1239|Firmicutes,249MB@186801|Clostridia,36DHC@31979|Clostridiaceae	186801|Clostridia	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD1_k127_5119028_3	1216932.CM240_2304	3.281e-11	69.0	COG4506@1|root,COG4506@2|Bacteria,1V8CS@1239|Firmicutes,24JQR@186801|Clostridia,36M2V@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF1934)	ywiB	-	-	-	-	-	-	-	-	-	-	-	DUF1934
HKD1_k127_5119028_0	1347392.CCEZ01000009_gene2310	9.675e-165	531.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36EY7@31979|Clostridiaceae	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_5119028_2	445973.CLOBAR_00228	4.583e-40	157.0	2AUKD@1|root,31K93@2|Bacteria,1V6PK@1239|Firmicutes,24J91@186801|Clostridia,25SMC@186804|Peptostreptococcaceae	186801|Clostridia	S	Stage II sporulation protein R (spore_II_R)	spoIIR	-	-	ko:K06387	-	-	-	-	ko00000	-	-	-	Spore_II_R
HKD1_k127_5120067_1	2754.EH55_09255	5.289e-47	171.0	COG2185@1|root,COG2185@2|Bacteria,3TAYI@508458|Synergistetes	508458|Synergistetes	I	PFAM cobalamin B12-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding
HKD1_k127_5120067_0	2754.EH55_09250	1.311e-230	724.0	COG1884@1|root,COG1884@2|Bacteria,3T9QP@508458|Synergistetes	508458|Synergistetes	I	Methylmalonyl-CoA mutase	-	-	-	-	-	-	-	-	-	-	-	-	MM_CoA_mutase
HKD1_k127_5120067_2	1122947.FR7_1849	2.861e-44	168.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4H2AZ@909932|Negativicutes	909932|Negativicutes	K	PFAM sigma-54 factor interaction domain-containing protein, Propionate catabolism activator domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PrpR_N,Sigma54_activat
HKD1_k127_5122275_0	1291050.JAGE01000001_gene77	7.456e-142	461.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,3WGKC@541000|Ruminococcaceae	186801|Clostridia	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
HKD1_k127_5124291_1	994573.T472_0200855	2.984e-55	195.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_5124291_2	445335.CBN_2104	4.271e-51	186.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,36I36@31979|Clostridiaceae	186801|Clostridia	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_5124291_0	697303.Thewi_0615	1.023e-74	259.0	COG1024@1|root,COG1024@2|Bacteria,1TQ89@1239|Firmicutes,247RK@186801|Clostridia,42EVN@68295|Thermoanaerobacterales	186801|Clostridia	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.17	ko:K01715	ko00650,ko01200,map00650,map01200	-	R03026	RC00831	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD1_k127_5124291_3	1519439.JPJG01000014_gene144	0.0001475	44.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,2N683@216572|Oscillospiraceae	186801|Clostridia	I	Psort location Cytoplasmic, score 9.97	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_5124525_4	931276.Cspa_c52930	2.516e-80	270.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_5124525_2	272563.CD630_27100	1.668e-117	384.0	COG1082@1|root,COG1082@2|Bacteria,1TT50@1239|Firmicutes,248RM@186801|Clostridia,25T1N@186804|Peptostreptococcaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_5124525_1	431943.CKL_1017	3.37e-131	424.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia,36GYG@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, LysR	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_5124525_5	931626.Awo_c04090	2.829e-78	263.0	COG1592@1|root,COG1592@2|Bacteria,1V1MI@1239|Firmicutes,24GXJ@186801|Clostridia	186801|Clostridia	C	PFAM Rubrerythrin	-	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_5124525_0	857293.CAAU_1921	1.967e-181	575.0	COG0531@1|root,COG0531@2|Bacteria,1TSSB@1239|Firmicutes,25B81@186801|Clostridia,36WAW@31979|Clostridiaceae	186801|Clostridia	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD1_k127_5124525_6	1266845.Q783_07955	1.974e-25	106.0	COG1968@1|root,COG1968@2|Bacteria,1TPFA@1239|Firmicutes,4HB0M@91061|Bacilli,27FGA@186828|Carnobacteriaceae	91061|Bacilli	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD1_k127_5124525_3	509191.AEDB02000018_gene288	3.981e-89	296.0	2AHVT@1|root,3188J@2|Bacteria,1V8V5@1239|Firmicutes,24FT6@186801|Clostridia,3WM08@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5128966_0	536227.CcarbDRAFT_1573	1.482e-96	318.0	COG1004@1|root,COG1004@2|Bacteria,1TQFN@1239|Firmicutes,25B1W@186801|Clostridia,36W7P@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	ywqF	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD1_k127_5128966_1	1121101.HMPREF1532_04075	3.721e-57	214.0	COG5492@1|root,COG5492@2|Bacteria	2|Bacteria	N	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,SLH
HKD1_k127_5128966_2	580331.Thit_0192	7.562e-07	61.0	COG3693@1|root,COG5492@1|root,COG3693@2|Bacteria,COG5492@2|Bacteria,1UHTC@1239|Firmicutes,248KD@186801|Clostridia,42FVN@68295|Thermoanaerobacterales	186801|Clostridia	G	SMART Glycoside hydrolase, family 10	-	-	3.2.1.8	ko:K01181	-	-	-	-	ko00000,ko01000	-	-	-	CBM9_1,CBM_4_9,Glyco_hydro_10,Polysacc_deac_1,SLH
HKD1_k127_51332_0	641112.ACOK01000055_gene3798	5.436e-136	441.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3WGZU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_5137803_0	1128398.Curi_c19100	2.031e-111	375.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,268AV@186813|unclassified Clostridiales	186801|Clostridia	L	ATP-dependent helicase deoxyribonuclease subunit B	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
HKD1_k127_5137803_1	1499689.CCNN01000013_gene3077	7.285e-102	341.0	COG3481@1|root,COG3481@2|Bacteria,1TPIU@1239|Firmicutes,248SS@186801|Clostridia,36FR2@31979|Clostridiaceae	186801|Clostridia	S	domain protein	yhaM	-	-	ko:K03698	-	-	-	-	ko00000,ko01000,ko03019	-	-	-	HD,tRNA_anti-codon
HKD1_k127_5137803_2	1304284.L21TH_2158	1.788e-37	152.0	COG5662@1|root,COG5662@2|Bacteria,1UHWV@1239|Firmicutes,24JF8@186801|Clostridia,36K4C@31979|Clostridiaceae	186801|Clostridia	K	Domain of unknown function (DUF4349)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4349,zf-HC2
HKD1_k127_5139_0	645512.GCWU000246_00208	3.527e-148	479.0	COG5505@1|root,COG5505@2|Bacteria,3TBX2@508458|Synergistetes	508458|Synergistetes	S	Protein of unknown function (DUF819)	-	-	-	-	-	-	-	-	-	-	-	-	DUF819
HKD1_k127_5139_1	536227.CcarbDRAFT_2547	9.142e-134	433.0	COG2355@1|root,COG2355@2|Bacteria,1UA7M@1239|Firmicutes,24AE6@186801|Clostridia,36EIQ@31979|Clostridiaceae	186801|Clostridia	E	PFAM Peptidase M19, renal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD1_k127_5144004_1	994573.T472_0217930	2.577e-90	300.0	COG3185@1|root,COG3185@2|Bacteria,1TQT2@1239|Firmicutes,249CY@186801|Clostridia,36FUI@31979|Clostridiaceae	186801|Clostridia	E	Acyclic terpene utilisation family protein AtuA	-	-	-	-	-	-	-	-	-	-	-	-	AtuA
HKD1_k127_5144004_0	994573.T472_0217935	2.358e-180	574.0	COG2851@1|root,COG2851@2|Bacteria,1TQQH@1239|Firmicutes,24A61@186801|Clostridia,36FUA@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM citrate H symporter, CitMHS family	citN	-	-	ko:K03300	-	-	-	-	ko00000	2.A.11	-	-	CitMHS
HKD1_k127_5147200_0	1301100.HG529329_gene4462	9.019e-87	291.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,36DVG@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the thiolase family	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_5147200_1	1487921.DP68_05630	3.305e-13	77.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
HKD1_k127_5161477_2	693746.OBV_10720	1.004e-36	143.0	2E9ZM@1|root,32W18@2|Bacteria,1VEBB@1239|Firmicutes,25DM9@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2680)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2680
HKD1_k127_5161477_1	37659.JNLN01000001_gene41	5.676e-117	380.0	COG0745@1|root,COG0745@2|Bacteria,1TPZ0@1239|Firmicutes,249IC@186801|Clostridia,36F6J@31979|Clostridiaceae	186801|Clostridia	T	Two component transcriptional regulator, winged helix family	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_5161477_0	37659.JNLN01000001_gene42	3.783e-138	447.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36GUR@31979|Clostridiaceae	186801|Clostridia	T	histidine kinase HAMP region domain protein	-	-	2.7.13.3	ko:K07651,ko:K07652	ko02020,map02020	M00458,M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA
HKD1_k127_5168675_0	340099.Teth39_1689	1.796e-150	494.0	COG4166@1|root,COG4166@2|Bacteria,1TNYQ@1239|Firmicutes,25E4B@186801|Clostridia,42FZA@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM extracellular solute-binding protein, family 5	-	-	-	ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_5168675_2	580340.Tlie_0496	2.379e-119	397.0	COG1301@1|root,COG1301@2|Bacteria,3T9WV@508458|Synergistetes	508458|Synergistetes	U	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD1_k127_5168675_1	1304284.L21TH_2348	6.119e-132	428.0	COG1508@1|root,COG1508@2|Bacteria,1TQ0H@1239|Firmicutes,2480F@186801|Clostridia,36ENH@31979|Clostridiaceae	186801|Clostridia	K	RNA polymerase sigma54 factor	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD1_k127_5170864_2	1121289.JHVL01000055_gene527	2.349e-39	147.0	COG2057@1|root,COG2057@2|Bacteria,1TNY5@1239|Firmicutes,247ZM@186801|Clostridia,36GAR@31979|Clostridiaceae	186801|Clostridia	I	3-oxoacid CoA-transferase, B subunit	ctfB	-	2.8.3.5,2.8.3.8,2.8.3.9	ko:K01029,ko:K01035	ko00072,ko00280,ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00072,map00280,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R00410,R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_5170864_1	994573.T472_0204275	5.172e-91	303.0	COG1788@1|root,COG1788@2|Bacteria,1V21Q@1239|Firmicutes,25E61@186801|Clostridia,36UK0@31979|Clostridiaceae	186801|Clostridia	I	TIGRFAM 3-oxoacid CoA-transferase, A subunit	-	-	2.8.3.8,2.8.3.9	ko:K01034	ko00310,ko00627,ko00640,ko00650,ko01100,ko01120,ko02020,map00310,map00627,map00640,map00650,map01100,map01120,map02020	-	R01179,R01359,R01365,R07832	RC00012,RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD1_k127_5170864_0	1321784.HMPREF1987_01906	4.959e-178	565.0	COG0183@1|root,COG0183@2|Bacteria,1TP07@1239|Firmicutes,2482I@186801|Clostridia,25R7H@186804|Peptostreptococcaceae	186801|Clostridia	I	Belongs to the thiolase family	phbA	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD1_k127_5173617_2	457415.HMPREF1006_00693	2.569e-91	308.0	28H7K@1|root,2Z7JT@2|Bacteria,3TC6Z@508458|Synergistetes	508458|Synergistetes	P	2-keto-3-deoxygluconate permease	-	-	-	-	-	-	-	-	-	-	-	-	KdgT
HKD1_k127_5173617_3	1121422.AUMW01000013_gene1496	0.0005692	43.0	COG0447@1|root,COG0447@2|Bacteria,1UHNU@1239|Firmicutes,24DVY@186801|Clostridia,260SS@186807|Peptococcaceae	186801|Clostridia	H	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)	menB	-	4.1.3.36	ko:K01661	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R07263	RC01923	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_5173617_1	2754.EH55_09230	4.598e-164	523.0	COG1902@1|root,COG1902@2|Bacteria	2|Bacteria	C	pentaerythritol trinitrate reductase activity	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_5173617_0	457415.HMPREF1006_00695	3.991e-280	870.0	COG1021@1|root,COG1021@2|Bacteria,3TCJG@508458|Synergistetes	508458|Synergistetes	Q	AMP-binding enzyme C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD1_k127_5174121_1	903814.ELI_0441	3.87e-17	84.0	2E4EX@1|root,32ZA3@2|Bacteria,1VEQT@1239|Firmicutes,24QUI@186801|Clostridia,25XR7@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5174121_0	411468.CLOSCI_02625	2.936e-64	233.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,21YJ0@1506553|Lachnoclostridium	186801|Clostridia	NU	Psort location CytoplasmicMembrane, score 9.97	gspF	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD1_k127_5174121_2	1304284.L21TH_1967	9.505e-10	67.0	2EFQW@1|root,339GX@2|Bacteria,1VH4T@1239|Firmicutes,24R6F@186801|Clostridia,36NNT@31979|Clostridiaceae	186801|Clostridia	S	Family of unknown function (DUF5317)	-	-	-	-	-	-	-	-	-	-	-	-	DUF5317
HKD1_k127_5175615_1	935948.KE386495_gene1106	5.189e-07	53.0	COG1763@1|root,COG1763@2|Bacteria,1UI2K@1239|Firmicutes,24A23@186801|Clostridia	186801|Clostridia	H	Mo-molybdopterin cofactor biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5175615_0	1347392.CCEZ01000049_gene1646	9.369e-149	473.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_5181598_1	1347392.CCEZ01000013_gene2654	1.2e-19	89.0	COG0860@1|root,COG0860@2|Bacteria,1TQ74@1239|Firmicutes,24FT2@186801|Clostridia,36I6H@31979|Clostridiaceae	186801|Clostridia	M	N-acetylmuramoyl-L-alanine amidase	cwlD	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3
HKD1_k127_5181598_0	1304284.L21TH_2303	4.365e-38	150.0	2C0MY@1|root,2ZC2Z@2|Bacteria,1V9XB@1239|Firmicutes,24PCF@186801|Clostridia,36J6H@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5185530_3	1347392.CCEZ01000074_gene1845	1.785e-27	112.0	COG0180@1|root,COG0180@2|Bacteria,1TPY7@1239|Firmicutes,248RC@186801|Clostridia,36DNK@31979|Clostridiaceae	186801|Clostridia	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD1_k127_5185530_0	1347392.CCEZ01000007_gene2025	5.313e-178	566.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_5185530_2	1131462.DCF50_p2400	8.867e-50	182.0	COG4978@1|root,COG4978@2|Bacteria,1V8I8@1239|Firmicutes,24NFI@186801|Clostridia,2633X@186807|Peptococcaceae	186801|Clostridia	KT	Bacterial transcription activator, effector binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD1_k127_5185530_1	1033810.HLPCO_000685	1.749e-139	447.0	COG1217@1|root,COG1217@2|Bacteria,2NNY7@2323|unclassified Bacteria	2|Bacteria	T	Elongation factor G C-terminus	typA	GO:0000027,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006950,GO:0006996,GO:0008150,GO:0009266,GO:0009408,GO:0009409,GO:0009628,GO:0009987,GO:0016043,GO:0022607,GO:0022613,GO:0022618,GO:0034622,GO:0042254,GO:0042255,GO:0042273,GO:0043933,GO:0044085,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0065003,GO:0070925,GO:0071826,GO:0071840	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_5193858_1	1280692.AUJL01000019_gene909	0.0006524	42.0	COG0438@1|root,COG0438@2|Bacteria,1UYM0@1239|Firmicutes,24C85@186801|Clostridia	186801|Clostridia	M	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD1_k127_5193858_0	1280692.AUJL01000019_gene904	1.565e-143	464.0	COG0438@1|root,COG0438@2|Bacteria,1TRCM@1239|Firmicutes,24B86@186801|Clostridia,36IK4@31979|Clostridiaceae	186801|Clostridia	M	Glycosyltransferase, group 1 family protein	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1
HKD1_k127_5198599_1	350688.Clos_0115	1.411e-41	160.0	COG0613@1|root,COG0613@2|Bacteria,1V3Z7@1239|Firmicutes,24KHP@186801|Clostridia,36II4@31979|Clostridiaceae	186801|Clostridia	S	DNA polymerase alpha chain like domain	-	-	-	-	-	-	-	-	-	-	-	-	PHP
HKD1_k127_5198599_0	445971.ANASTE_00500	7.48e-138	445.0	COG0252@1|root,COG0252@2|Bacteria,1TPP9@1239|Firmicutes,248F3@186801|Clostridia,25VSV@186806|Eubacteriaceae	186801|Clostridia	EJ	Psort location Cytoplasmic, score	ansA	-	3.5.1.1	ko:K01424	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Asparaginase
HKD1_k127_5198599_2	1128398.Curi_c09680	1.116e-29	119.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,268XS@186813|unclassified Clostridiales	186801|Clostridia	J	RNA pseudouridylate synthase	rluA	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD1_k127_5198716_1	1280698.AUJS01000056_gene1448	6.821e-86	287.0	COG1126@1|root,COG1126@2|Bacteria,1TNYD@1239|Firmicutes,247QZ@186801|Clostridia,27UW9@189330|Dorea	186801|Clostridia	E	COG COG1126 ABC-type polar amino acid transport system, ATPase component	-	-	3.6.3.21	ko:K02028	-	M00236	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.3	-	-	ABC_tran
HKD1_k127_5198716_0	536227.CcarbDRAFT_1867	1.156e-89	299.0	COG0765@1|root,COG0765@2|Bacteria,1V9CB@1239|Firmicutes,24CMF@186801|Clostridia,36GB9@31979|Clostridiaceae	186801|Clostridia	E	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K10037	ko02010,map02010	M00227	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3.2	-	-	BPD_transp_1
HKD1_k127_5198716_2	332101.JIBU02000055_gene1882	1.839e-69	240.0	COG0834@1|root,COG0834@2|Bacteria,1V9I4@1239|Firmicutes,24F7Q@186801|Clostridia,36HXK@31979|Clostridiaceae	186801|Clostridia	ET	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	SBP_bac_3
HKD1_k127_52028_0	1128398.Curi_c01310	1.575e-19	89.0	COG2846@1|root,COG2846@2|Bacteria,1VET8@1239|Firmicutes,24QPY@186801|Clostridia,269X5@186813|unclassified Clostridiales	186801|Clostridia	D	Domain of unknown function (DUF1858)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1858
HKD1_k127_5219730_1	1121289.JHVL01000006_gene2875	2.597e-152	489.0	COG2265@1|root,COG2265@2|Bacteria,1TP4H@1239|Firmicutes,248B4@186801|Clostridia,36E34@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	rumA	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TRAM,tRNA_U5-meth_tr
HKD1_k127_5219730_0	1120998.AUFC01000005_gene637	2.377e-195	611.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,3WCQ4@538999|Clostridiales incertae sedis	186801|Clostridia	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD1_k127_5219812_2	720554.Clocl_2149	2.258e-29	120.0	COG1496@1|root,COG1496@2|Bacteria,1TS34@1239|Firmicutes,248TD@186801|Clostridia,3WHV2@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the multicopper oxidase YfiH RL5 family	yfiH	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD1_k127_5219812_0	999419.HMPREF1077_02571	1.534e-91	305.0	COG3294@1|root,COG3294@2|Bacteria,4NJAE@976|Bacteroidetes,2FNKA@200643|Bacteroidia,22WQF@171551|Porphyromonadaceae	976|Bacteroidetes	S	Metal dependent phosphohydrolases with conserved 'HD' motif.	-	-	-	-	-	-	-	-	-	-	-	-	HD
HKD1_k127_5219812_1	555088.DealDRAFT_1252	1.079e-61	216.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia	186801|Clostridia	S	Abc transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_5222205_3	1128398.Curi_c05650	1.474e-62	220.0	COG0466@1|root,COG0466@2|Bacteria,1TNYG@1239|Firmicutes,247SH@186801|Clostridia,268F6@186813|unclassified Clostridiales	186801|Clostridia	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD1_k127_5222205_0	1304284.L21TH_2375	1.876e-204	642.0	COG1219@1|root,COG1219@2|Bacteria,1TQ00@1239|Firmicutes,2481T@186801|Clostridia,36EA3@31979|Clostridiaceae	186801|Clostridia	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD1_k127_5222205_2	1121289.JHVL01000006_gene2869	2.015e-101	332.0	COG0740@1|root,COG0740@2|Bacteria,1TQ91@1239|Firmicutes,247QY@186801|Clostridia,36ED5@31979|Clostridiaceae	186801|Clostridia	O	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_5222205_1	1304284.L21TH_2373	1.9e-123	409.0	COG0544@1|root,COG0544@2|Bacteria,1TQQ8@1239|Firmicutes,248C3@186801|Clostridia,36DYI@31979|Clostridiaceae	186801|Clostridia	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD1_k127_5222205_5	318464.IO99_02670	2.217e-46	173.0	COG1670@1|root,COG1670@2|Bacteria,1V2FI@1239|Firmicutes,25B0M@186801|Clostridia,36WDN@31979|Clostridiaceae	186801|Clostridia	J	Acetyltransferase (GNAT) domain	-	-	2.3.1.128	ko:K03790	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_3
HKD1_k127_5222205_4	742766.HMPREF9455_01765	2.402e-48	175.0	COG1304@1|root,COG1304@2|Bacteria,4NKD6@976|Bacteroidetes,2FXIF@200643|Bacteroidia,23064@171551|Porphyromonadaceae	976|Bacteroidetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5222205_6	742766.HMPREF9455_01765	1.958e-12	66.0	COG1304@1|root,COG1304@2|Bacteria,4NKD6@976|Bacteroidetes,2FXIF@200643|Bacteroidia,23064@171551|Porphyromonadaceae	976|Bacteroidetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5227169_0	545243.BAEV01000022_gene2019	6.31e-113	368.0	COG0550@1|root,COG0551@1|root,COG0550@2|Bacteria,COG0551@2|Bacteria,1TPJD@1239|Firmicutes,24810@186801|Clostridia,36DHG@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topB	-	5.99.1.2	ko:K03169	-	-	-	-	ko00000,ko01000,ko03032	-	-	-	Topoisom_bac,Toprim
HKD1_k127_5227169_1	1408422.JHYF01000016_gene41	1.311e-06	56.0	2FH6V@1|root,3491A@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5228074_1	1347392.CCEZ01000016_gene2943	1.836e-34	134.0	COG0600@1|root,COG0600@2|Bacteria,1TR6A@1239|Firmicutes,247VM@186801|Clostridia,36F6D@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	ssuC_2	-	-	ko:K02050	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	BPD_transp_1
HKD1_k127_5228074_0	1121289.JHVL01000001_gene1936	1.748e-105	348.0	COG0084@1|root,COG0084@2|Bacteria,1TNY1@1239|Firmicutes,248HE@186801|Clostridia,36EDX@31979|Clostridiaceae	186801|Clostridia	L	Hydrolase, TatD family	tatD	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD1_k127_5228074_2	195103.CPF_2901	3.162e-21	95.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,36I75@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD1_k127_5232048_1	293826.Amet_2913	1.624e-28	115.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae	186801|Clostridia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N,RCC1_2
HKD1_k127_5232048_0	1031288.AXAA01000002_gene1467	2.303e-132	429.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,36DZS@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	appD	-	-	ko:K02031	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	ABC_tran,oligo_HPY
HKD1_k127_5241230_2	1301100.HG529340_gene2418	4.527e-98	324.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,36ETY@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_5241230_0	1304284.L21TH_2533	4.694e-150	483.0	COG0520@1|root,COG0520@2|Bacteria,1TQ1W@1239|Firmicutes,249CS@186801|Clostridia,36EP2@31979|Clostridiaceae	186801|Clostridia	E	TIGRFAM cysteine desulfurase family protein	csd2	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD1_k127_5241230_6	1121289.JHVL01000038_gene2971	1.408e-09	69.0	2BA2F@1|root,323G7@2|Bacteria,1UPZV@1239|Firmicutes,257M9@186801|Clostridia,36NJK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5241230_5	1304284.L21TH_1933	7.399e-16	86.0	COG1286@1|root,COG1286@2|Bacteria,1VH6E@1239|Firmicutes,24T69@186801|Clostridia,36NWS@31979|Clostridiaceae	186801|Clostridia	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD1_k127_5241230_3	1304284.L21TH_1927	1.814e-52	191.0	COG0425@1|root,COG0425@2|Bacteria,1V6BY@1239|Firmicutes,24JW8@186801|Clostridia,36IYS@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the sulfur carrier protein TusA family	yedF	-	-	ko:K04085	ko04122,map04122	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	DrsE,TusA
HKD1_k127_5241230_4	1304284.L21TH_1925	5.042e-21	94.0	COG4481@1|root,COG4481@2|Bacteria,1VEQ7@1239|Firmicutes,24QKA@186801|Clostridia,36MMG@31979|Clostridiaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF951)	-	-	-	-	-	-	-	-	-	-	-	-	DUF951
HKD1_k127_5241230_1	552396.HMPREF0863_00200	7.657e-134	440.0	COG0534@1|root,COG0534@2|Bacteria,1TQ56@1239|Firmicutes,3VQ3H@526524|Erysipelotrichia	526524|Erysipelotrichia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_5248783_1	1120746.CCNL01000011_gene1489	5.252e-52	186.0	COG1377@1|root,COG1377@2|Bacteria,2NPBX@2323|unclassified Bacteria	2|Bacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401,ko:K03229,ko:K04061,ko:K13820,ko:K22510	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	Bac_export_2
HKD1_k127_5248783_0	1105031.HMPREF1141_2824	3.931e-130	424.0	COG1298@1|root,COG1298@2|Bacteria,1TQBM@1239|Firmicutes,248F5@186801|Clostridia,36EDM@31979|Clostridiaceae	186801|Clostridia	N	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhA	-	-	ko:K02400	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	FHIPEP
HKD1_k127_5251055_1	1128398.Curi_c23690	5.497e-73	253.0	COG0037@1|root,COG0037@2|Bacteria,1TPXP@1239|Firmicutes,248TY@186801|Clostridia,268A3@186813|unclassified Clostridiales	186801|Clostridia	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3,TilS,TilS_C
HKD1_k127_5251055_2	1128398.Curi_c23720	2.199e-31	141.0	COG2208@1|root,COG2208@2|Bacteria,1TQ92@1239|Firmicutes,247XG@186801|Clostridia,267WD@186813|unclassified Clostridiales	186801|Clostridia	KT	Sigma factor PP2C-like phosphatases	spoIIE	-	3.1.3.16	ko:K06382	-	-	-	-	ko00000,ko01000	-	-	-	SpoIIE
HKD1_k127_5251055_4	1347392.CCEZ01000020_gene944	1.05e-14	81.0	COG2919@1|root,COG2919@2|Bacteria,1VIBA@1239|Firmicutes,24R6I@186801|Clostridia,36N4V@31979|Clostridiaceae	186801|Clostridia	D	Septum formation initiator	-	-	-	ko:K13052	-	-	-	-	ko00000,ko03036	-	-	-	DivIC
HKD1_k127_5251055_5	1304284.L21TH_0777	1.349e-13	78.0	2EFTM@1|root,32YR5@2|Bacteria,1VFQQ@1239|Firmicutes,24QUB@186801|Clostridia,36NB0@31979|Clostridiaceae	186801|Clostridia	S	Spore cortex biosynthesis protein YabQ	yabQ	-	-	-	-	-	-	-	-	-	-	-	Spore_YabQ
HKD1_k127_5251055_3	203119.Cthe_2659	1.225e-16	83.0	2E3ZZ@1|root,32YWW@2|Bacteria,1VEIW@1239|Firmicutes,24QNQ@186801|Clostridia,3WKKJ@541000|Ruminococcaceae	186801|Clostridia	S	Sporulation protein YabP	yabP	-	-	-	-	-	-	-	-	-	-	-	YabP
HKD1_k127_5251055_0	1507.HMPREF0262_00983	2.551e-80	281.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,24AKU@186801|Clostridia,36DGS@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator	tetA	-	-	ko:K08151,ko:K08153	-	M00668,M00717	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_5252792_3	666686.B1NLA3E_05100	5.065e-87	296.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,4I312@91061|Bacilli,1ZC7S@1386|Bacillus	91061|Bacilli	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_5252792_2	1304284.L21TH_1413	2.483e-97	331.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia,36GDQ@31979|Clostridiaceae	186801|Clostridia	M	Beta-lactamase enzyme family	dacF	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_5252792_0	865861.AZSU01000004_gene1041	3.065e-230	729.0	COG4166@1|root,COG4166@2|Bacteria,1VRU1@1239|Firmicutes,255ES@186801|Clostridia,36H82@31979|Clostridiaceae	186801|Clostridia	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	ko:K02035,ko:K15580	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	SBP_bac_5
HKD1_k127_5252792_1	1209989.TepiRe1_0846	5.138e-125	407.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,42FJK@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033,ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD1_k127_5252792_4	1209989.TepiRe1_0847	2.653e-17	83.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,42F60@68295|Thermoanaerobacterales	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	oppC	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD1_k127_5259981_1	290402.Cbei_2538	4.588e-44	162.0	COG0720@1|root,COG0720@2|Bacteria,1VAJX@1239|Firmicutes,24JS9@186801|Clostridia,36JJD@31979|Clostridiaceae	186801|Clostridia	H	synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_5259981_0	1033810.HLPCO_002628	5.717e-89	295.0	COG0780@1|root,COG0780@2|Bacteria,2NPZV@2323|unclassified Bacteria	2|Bacteria	S	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)	queF	GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008616,GO:0009058,GO:0009116,GO:0009119,GO:0009163,GO:0009987,GO:0016491,GO:0016645,GO:0016646,GO:0016651,GO:0016657,GO:0018130,GO:0019438,GO:0033739,GO:0034404,GO:0034641,GO:0034654,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046116,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:1901135,GO:1901137,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	1.7.1.13	ko:K06879,ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	iSFV_1184.SFV_2663,iSF_1195.SF2807,iS_1188.S3002	QueF,QueF_N
HKD1_k127_5262628_1	1511.CLOST_1668	4.137e-26	109.0	COG0310@1|root,COG0310@2|Bacteria,1TQVK@1239|Firmicutes,248ZZ@186801|Clostridia,25SD1@186804|Peptostreptococcaceae	186801|Clostridia	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiM	-	-	ko:K02007	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiM
HKD1_k127_5262628_2	1443122.Z958_08470	4.475e-26	110.0	COG1930@1|root,COG1930@2|Bacteria,1VF03@1239|Firmicutes,24MYG@186801|Clostridia,36JHY@31979|Clostridiaceae	186801|Clostridia	P	Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import	cbiN	-	-	ko:K02009	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18	-	-	CbiN
HKD1_k127_5262628_0	1511.CLOST_0269	4.274e-29	122.0	COG0619@1|root,COG0619@2|Bacteria,1V0B0@1239|Firmicutes,24A4J@186801|Clostridia,25RAD@186804|Peptostreptococcaceae	186801|Clostridia	P	Cobalt transport protein	cbiQ	-	-	ko:K02008	ko02010,map02010	M00245,M00246	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.18,3.A.1.22,3.A.1.23	-	-	CbiQ
HKD1_k127_5265928_5	357809.Cphy_3119	2.801e-27	113.0	COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes,24CPD@186801|Clostridia,222H5@1506553|Lachnoclostridium	186801|Clostridia	M	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_5265928_2	1123009.AUID01000016_gene54	2.416e-85	289.0	COG1414@1|root,COG1414@2|Bacteria,1TRMW@1239|Firmicutes,24BQA@186801|Clostridia,269P4@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix isocitrate lyase regulation	-	-	-	-	-	-	-	-	-	-	-	-	HTH_IclR,IclR
HKD1_k127_5265928_0	1123009.AUID01000016_gene53	0.0	1058.0	COG1252@1|root,COG1252@2|Bacteria,1TR6X@1239|Firmicutes,249J5@186801|Clostridia,26AJF@186813|unclassified Clostridiales	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.6.99.3	ko:K03885	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	DoxD,DoxX,Pyr_redox_2
HKD1_k127_5265928_1	1123009.AUID01000016_gene52	1.073e-136	441.0	COG0142@1|root,COG0142@2|Bacteria,1TR0U@1239|Firmicutes,24AW3@186801|Clostridia,26BGP@186813|unclassified Clostridiales	186801|Clostridia	H	Polyprenyl synthetase	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD1_k127_5265928_3	394503.Ccel_1113	2.317e-75	259.0	COG1575@1|root,COG1575@2|Bacteria,1TSZV@1239|Firmicutes,24A9J@186801|Clostridia,36EUQ@31979|Clostridiaceae	186801|Clostridia	H	PFAM UbiA prenyltransferase	menA	-	2.5.1.74	ko:K02548	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116	R05617,R06858,R10757	RC02935,RC02936,RC03264	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD1_k127_5265928_4	243231.GSU2508	4.977e-30	126.0	COG0457@1|root,COG0457@2|Bacteria,1NNJ6@1224|Proteobacteria,42PBD@68525|delta/epsilon subdivisions,2WKWJ@28221|Deltaproteobacteria	28221|Deltaproteobacteria	M	Tetratricopeptide TPR_2 repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD1_k127_5268588_0	1347392.CCEZ01000074_gene1777	1.165e-85	290.0	COG1768@1|root,COG1768@2|Bacteria,1V3XB@1239|Firmicutes,249BN@186801|Clostridia,36DUA@31979|Clostridiaceae	186801|Clostridia	S	PFAM Metallophosphoesterase	-	-	-	ko:K07099	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_5273117_2	1410668.JNKC01000012_gene1088	8.363e-43	159.0	COG3053@1|root,COG3053@2|Bacteria,1TSGQ@1239|Firmicutes,248Y4@186801|Clostridia,36EF0@31979|Clostridiaceae	186801|Clostridia	C	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase	citC	-	6.2.1.22	ko:K01910	ko02020,map02020	-	R04449	RC00012,RC00039	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_1,Acetyltransf_10,Citrate_ly_lig
HKD1_k127_5273117_3	1540257.JQMW01000011_gene1878	1.108e-24	106.0	COG3052@1|root,COG3052@2|Bacteria,1VEZZ@1239|Firmicutes,24QMJ@186801|Clostridia,36N6K@31979|Clostridiaceae	186801|Clostridia	C	Covalent carrier of the coenzyme of citrate lyase	citD	-	-	ko:K01646	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001	-	-	-	ACP
HKD1_k127_5273117_1	1410668.JNKC01000012_gene1086	3.477e-152	484.0	COG2301@1|root,COG2301@2|Bacteria,1TPDY@1239|Firmicutes,24AIH@186801|Clostridia,36E49@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS12480	HpcH_HpaI,Malate_synthase
HKD1_k127_5273117_0	1410668.JNKC01000012_gene1085	7.304e-258	802.0	COG3051@1|root,COG3051@2|Bacteria,1TPN3@1239|Firmicutes,247QD@186801|Clostridia,36EAH@31979|Clostridiaceae	186801|Clostridia	C	Citrate lyase alpha subunit	-	-	2.8.3.10	ko:K01643	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	CitF
HKD1_k127_5273117_4	1410668.JNKC01000012_gene1084	7.886e-14	72.0	COG3697@1|root,COG3697@2|Bacteria,1VB3E@1239|Firmicutes,24MQ6@186801|Clostridia,36VWP@31979|Clostridiaceae	186801|Clostridia	HI	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase	citX	-	2.7.7.61	ko:K05964	ko02020,map02020	-	R10706	-	ko00000,ko00001,ko01000	-	-	-	CitX
HKD1_k127_5277321_0	1031288.AXAA01000018_gene22	5.259e-183	581.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,247TD@186801|Clostridia,36DF4@31979|Clostridiaceae	186801|Clostridia	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpC	-	-	ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N,UVR
HKD1_k127_5277321_1	1120746.CCNL01000014_gene2195	5.281e-18	83.0	COG0173@1|root,COG0173@2|Bacteria,2NNP3@2323|unclassified Bacteria	2|Bacteria	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD1_k127_5280612_0	994573.T472_0203915	1.804e-108	355.0	COG1432@1|root,COG1432@2|Bacteria,1TTAC@1239|Firmicutes,249NE@186801|Clostridia,36DIB@31979|Clostridiaceae	186801|Clostridia	S	NYN domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD1_k127_5280612_1	1121947.AUHK01000020_gene144	5.257e-63	219.0	COG0225@1|root,COG0229@1|root,COG0225@2|Bacteria,COG0229@2|Bacteria,1TQ3E@1239|Firmicutes,247UT@186801|Clostridia,22GH0@1570339|Peptoniphilaceae	186801|Clostridia	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD1_k127_5280612_2	1285586.H131_04889	5.637e-17	81.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,4HECI@91061|Bacilli,3IVXM@400634|Lysinibacillus	91061|Bacilli	E	Pyridoxal-phosphate dependent enzyme	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_5280810_3	1211817.CCAT010000007_gene1084	0.0001373	49.0	COG0739@1|root,COG0739@2|Bacteria,1VAC5@1239|Firmicutes,25E3G@186801|Clostridia,36FRG@31979|Clostridiaceae	186801|Clostridia	M	Peptidase family M23	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_5280810_1	203124.Tery_3191	2.354e-07	59.0	COG0517@1|root,COG1994@1|root,COG0517@2|Bacteria,COG1994@2|Bacteria,1G05Y@1117|Cyanobacteria,1H6X5@1150|Oscillatoriales	1117|Cyanobacteria	S	Belongs to the peptidase M50B family	-	GO:0003674,GO:0003824,GO:0003938,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006139,GO:0006163,GO:0006164,GO:0006183,GO:0006725,GO:0006753,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009116,GO:0009117,GO:0009119,GO:0009141,GO:0009142,GO:0009144,GO:0009145,GO:0009150,GO:0009152,GO:0009163,GO:0009165,GO:0009199,GO:0009201,GO:0009205,GO:0009206,GO:0009259,GO:0009260,GO:0009987,GO:0016491,GO:0016614,GO:0016616,GO:0018130,GO:0019438,GO:0019637,GO:0019693,GO:0034404,GO:0034641,GO:0034654,GO:0042278,GO:0042451,GO:0042455,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044464,GO:0046039,GO:0046128,GO:0046129,GO:0046390,GO:0046483,GO:0055086,GO:0055114,GO:0071704,GO:0072521,GO:0072522,GO:0090407,GO:1901068,GO:1901070,GO:1901135,GO:1901137,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901657,GO:1901659	-	ko:K06402	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	CBS,Peptidase_M50,Peptidase_M50B
HKD1_k127_5280810_2	536227.CcarbDRAFT_0925	2.368e-06	58.0	COG5513@1|root,COG5513@2|Bacteria,1V52X@1239|Firmicutes,25ER6@186801|Clostridia,36US0@31979|Clostridiaceae	186801|Clostridia	S	Domain of unknown function (DUF4163)	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1,DUF3298,DUF4163
HKD1_k127_5280810_0	1232443.BAIA02000095_gene3647	1.691e-75	259.0	COG0860@1|root,COG3103@1|root,COG0860@2|Bacteria,COG3103@2|Bacteria,1TQ50@1239|Firmicutes,249IF@186801|Clostridia,267SA@186813|unclassified Clostridiales	186801|Clostridia	MT	Bacterial SH3 domain	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	Amidase_3,SH3_3,SPOR
HKD1_k127_5282932_1	1304284.L21TH_1636	2.048e-71	254.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,36FHF@31979|Clostridiaceae	186801|Clostridia	K	cell envelope-related function transcriptional attenuator	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD1_k127_5282932_0	1304284.L21TH_1636	5.656e-77	269.0	COG1316@1|root,COG1316@2|Bacteria,1TR1B@1239|Firmicutes,24AAY@186801|Clostridia,36FHF@31979|Clostridiaceae	186801|Clostridia	K	cell envelope-related function transcriptional attenuator	lytR	-	-	-	-	-	-	-	-	-	-	-	LytR_C,LytR_cpsA_psr
HKD1_k127_5284590_0	536227.CcarbDRAFT_0119	3.646e-178	564.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,247ND@186801|Clostridia,36DJ5@31979|Clostridiaceae	186801|Clostridia	O	Molecular chaperone. Has ATPase activity	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
HKD1_k127_5284590_1	698769.JFBD01000048_gene203	6.582e-36	137.0	COG0326@1|root,COG0326@2|Bacteria,1TQEU@1239|Firmicutes,4HD5Z@91061|Bacilli,4C4NA@84406|Virgibacillus	91061|Bacilli	O	Hsp90 protein	htpG	-	-	ko:K04079	ko04141,ko04151,ko04217,ko04612,ko04621,ko04626,ko04657,ko04659,ko04914,ko04915,ko05200,ko05215,ko05418,map04141,map04151,map04217,map04612,map04621,map04626,map04657,map04659,map04914,map04915,map05200,map05215,map05418	-	-	-	ko00000,ko00001,ko01009,ko03029,ko03051,ko03110,ko04131,ko04147	-	-	-	HATPase_c,HATPase_c_3,HSP90
HKD1_k127_5289475_0	1321778.HMPREF1982_03349	6.663e-35	136.0	2ESAF@1|root,33JV5@2|Bacteria,1VMC6@1239|Firmicutes,24QW3@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5289475_1	350688.Clos_1080	8.801e-10	60.0	COG0500@1|root,COG2226@2|Bacteria,1V0C5@1239|Firmicutes,24IDC@186801|Clostridia,36P3J@31979|Clostridiaceae	186801|Clostridia	Q	PFAM UbiE COQ5 methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD1_k127_5295363_0	1499685.CCFJ01000041_gene1047	1.094e-169	537.0	COG0399@1|root,COG0399@2|Bacteria,1TPDH@1239|Firmicutes,4HDN8@91061|Bacilli,1ZQW8@1386|Bacillus	91061|Bacilli	E	Belongs to the DegT DnrJ EryC1 family	spsC	-	2.6.1.102	ko:K13010	ko00520,map00520	-	R10460	RC00006,RC00781	ko00000,ko00001,ko01000,ko01005,ko01007	-	-	-	DegT_DnrJ_EryC1
HKD1_k127_5295363_1	1117379.BABA_01570	6.463e-92	307.0	COG2148@1|root,COG2148@2|Bacteria,1TP7V@1239|Firmicutes,4HGEA@91061|Bacilli,1ZMM5@1386|Bacillus	91061|Bacilli	M	Bacterial sugar transferase	-	-	-	-	-	-	-	-	-	-	-	-	Bac_transf
HKD1_k127_5295363_2	86416.Clopa_0864	6.991e-28	115.0	COG2244@1|root,COG2244@2|Bacteria,1TQBD@1239|Firmicutes,24CYT@186801|Clostridia	186801|Clostridia	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt
HKD1_k127_5299329_2	1216932.CM240_0139	1.104e-132	427.0	COG2719@1|root,COG2719@2|Bacteria,1TRHQ@1239|Firmicutes,248CW@186801|Clostridia,36F7J@31979|Clostridiaceae	186801|Clostridia	S	stage V sporulation protein R	spoVR	-	-	ko:K06415	-	-	-	-	ko00000	-	-	-	SpoVR
HKD1_k127_5299329_1	663278.Ethha_0727	4.252e-172	548.0	COG2718@1|root,COG2718@2|Bacteria,1TQIN@1239|Firmicutes,24A3U@186801|Clostridia,3WGS2@541000|Ruminococcaceae	186801|Clostridia	S	Belongs to the UPF0229 family	yhbH	-	-	ko:K09786	-	-	-	-	ko00000	-	-	-	DUF444
HKD1_k127_5299329_0	663278.Ethha_0728	0.0	1108.0	COG2766@1|root,COG2766@2|Bacteria,1TRTW@1239|Firmicutes,248GE@186801|Clostridia,3WGH1@541000|Ruminococcaceae	186801|Clostridia	T	PFAM PrkA AAA domain	prkA	-	-	ko:K07180	-	-	-	-	ko00000	-	-	-	AAA_PrkA,PrkA
HKD1_k127_5299329_3	1321778.HMPREF1982_03954	1.854e-53	201.0	COG2966@1|root,COG2966@2|Bacteria,1TSE8@1239|Firmicutes,24A25@186801|Clostridia,268C3@186813|unclassified Clostridiales	186801|Clostridia	S	Putative threonine/serine exporter	-	-	-	-	-	-	-	-	-	-	-	-	ThrE
HKD1_k127_5300214_0	203119.Cthe_3024	4.415e-139	451.0	COG1009@1|root,COG1009@2|Bacteria,1TQW4@1239|Firmicutes,24A16@186801|Clostridia,3WHSP@541000|Ruminococcaceae	186801|Clostridia	CP	NADH-Ubiquinone oxidoreductase (complex I), chain 5	-	-	-	ko:K05565,ko:K14086	-	-	-	-	ko00000,ko02000	2.A.63.1,2.A.63.2	-	-	Proton_antipo_M,Proton_antipo_N
HKD1_k127_5300857_1	657322.FPR_12050	6.294e-104	340.0	COG0031@1|root,COG0031@2|Bacteria,1TP30@1239|Firmicutes,2497G@186801|Clostridia,3WG9Z@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_5300857_0	397287.C807_02101	3.181e-141	456.0	COG1135@1|root,COG1135@2|Bacteria,1TPPN@1239|Firmicutes,248PZ@186801|Clostridia,27I83@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system	metN	-	-	ko:K02071	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	ABC_tran,NIL
HKD1_k127_5300857_2	1458462.JNLK01000001_gene461	7.812e-74	254.0	COG2011@1|root,COG2011@2|Bacteria,1TRSY@1239|Firmicutes,24AZ9@186801|Clostridia,27JTY@186928|unclassified Lachnospiraceae	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	metI	-	-	ko:K02072	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	BPD_transp_1
HKD1_k127_5300857_3	1105031.HMPREF1141_1733	2.203e-61	216.0	COG1464@1|root,COG1464@2|Bacteria,1TQAS@1239|Firmicutes,247WV@186801|Clostridia,36DGV@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the nlpA lipoprotein family	metQ	-	-	ko:K02073	ko02010,map02010	M00238	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.24	-	-	Lipoprotein_9
HKD1_k127_5305219_4	742740.HMPREF9474_03584	5.854e-08	55.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,21Z53@1506553|Lachnoclostridium	186801|Clostridia	K	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS_8,Sigma54_activat
HKD1_k127_5305219_1	588581.Cpap_2061	6.943e-73	249.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,3WGUG@541000|Ruminococcaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_5305219_0	1304284.L21TH_1820	1.717e-179	567.0	COG0459@1|root,COG0459@2|Bacteria,1TP1T@1239|Firmicutes,248BG@186801|Clostridia,36E1F@31979|Clostridiaceae	186801|Clostridia	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD1_k127_5305219_3	865861.AZSU01000002_gene3080	3.779e-37	141.0	COG0234@1|root,COG0234@2|Bacteria,1V9ZM@1239|Firmicutes,24MMM@186801|Clostridia,36KFP@31979|Clostridiaceae	186801|Clostridia	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD1_k127_5305219_2	484770.UFO1_1478	1.034e-71	243.0	COG0191@1|root,COG0191@2|Bacteria,1TQ01@1239|Firmicutes,4H28N@909932|Negativicutes	909932|Negativicutes	G	aldolase class II	fba	-	4.1.2.13	ko:K01624	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167,M00344,M00345	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	F_bP_aldolase
HKD1_k127_5310832_0	580327.Tthe_0257	1.218e-123	409.0	COG0477@1|root,COG0477@2|Bacteria,1UI7B@1239|Firmicutes,25ECI@186801|Clostridia,42J7J@68295|Thermoanaerobacterales	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_3
HKD1_k127_5310832_1	931626.Awo_c26810	6.839e-79	268.0	COG1595@1|root,COG1595@2|Bacteria,1V4B8@1239|Firmicutes,24KEK@186801|Clostridia,25X2P@186806|Eubacteriaceae	186801|Clostridia	K	COG COG1595 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog	sigK_1	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_5310832_2	1410668.JNKC01000004_gene289	6.407e-33	141.0	2DPHY@1|root,33258@2|Bacteria,1UJMU@1239|Firmicutes,25F5U@186801|Clostridia,36KNF@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
HKD1_k127_5311586_2	1540257.JQMW01000009_gene3041	2.226e-62	216.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,36DT0@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
HKD1_k127_5311586_3	1449050.JNLE01000003_gene3315	3.094e-54	194.0	COG1781@1|root,COG1781@2|Bacteria,1V6U9@1239|Firmicutes,24JJU@186801|Clostridia,36JII@31979|Clostridiaceae	186801|Clostridia	F	aspartate carbamoyltransferase, regulatory	pyrI	-	-	ko:K00610	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002	-	-	-	PyrI,PyrI_C
HKD1_k127_5311586_0	1128398.Curi_c07050	1.841e-118	387.0	COG0284@1|root,COG0284@2|Bacteria,1TQ7P@1239|Firmicutes,247SZ@186801|Clostridia,2684J@186813|unclassified Clostridiales	186801|Clostridia	F	Belongs to the OMP decarboxylase family. Type 2 subfamily	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17585	OMPdecase
HKD1_k127_5311586_1	536232.CLM_3649	1.74e-77	266.0	COG0543@1|root,COG0543@2|Bacteria,1TQ5D@1239|Firmicutes,24AY2@186801|Clostridia,36E7E@31979|Clostridiaceae	186801|Clostridia	C	Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(	pyrK	-	-	ko:K02823	ko00240,ko01100,map00240,map01100	-	-	-	ko00000,ko00001	-	-	iHN637.CLJU_RS17580	DHODB_Fe-S_bind,FAD_binding_6,NAD_binding_1
HKD1_k127_5311586_4	428125.CLOLEP_00361	2.91e-07	52.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,3WGC5@541000|Ruminococcaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_5315300_5	333138.LQ50_05950	1.291e-10	68.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,4HC3Q@91061|Bacilli,1ZCCF@1386|Bacillus	91061|Bacilli	J	ribonuclease, Rne Rng family	cafA	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD1_k127_5315300_2	865861.AZSU01000005_gene876	6.402e-39	148.0	COG0261@1|root,COG0261@2|Bacteria,1V9YH@1239|Firmicutes,24MRS@186801|Clostridia,36JGP@31979|Clostridiaceae	186801|Clostridia	J	This protein binds to 23S rRNA in the presence of protein L20	rplU	-	-	ko:K02888	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L21p
HKD1_k127_5315300_4	1273103.NM10_09088	1.379e-15	80.0	COG2868@1|root,COG2868@2|Bacteria,1TU8A@1239|Firmicutes,4H5SB@909932|Negativicutes	909932|Negativicutes	J	Cysteine protease Prp	-	-	-	ko:K07584	-	-	-	-	ko00000	-	-	-	Peptidase_Prp
HKD1_k127_5315300_1	138119.DSY3165	1.01e-43	160.0	COG0211@1|root,COG0211@2|Bacteria,1V6HW@1239|Firmicutes,24N3D@186801|Clostridia,262E4@186807|Peptococcaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL27 family	rpmA	-	-	ko:K02899	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27
HKD1_k127_5315300_0	1304284.L21TH_2116	1.445e-170	546.0	COG0536@1|root,COG0536@2|Bacteria,1TPX7@1239|Firmicutes,247SP@186801|Clostridia,36DEA@31979|Clostridiaceae	186801|Clostridia	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	DUF1967,GTP1_OBG,MMR_HSR1
HKD1_k127_5315300_3	1304284.L21TH_2114	4.715e-37	141.0	COG1534@1|root,COG1534@2|Bacteria,1VEGM@1239|Firmicutes,24QZB@186801|Clostridia,36KS2@31979|Clostridiaceae	186801|Clostridia	J	RNA-binding protein	yhbY	-	-	ko:K07574	-	-	-	-	ko00000,ko03009	-	-	-	CRS1_YhbY
HKD1_k127_5315784_1	1304284.L21TH_2221	3.217e-38	147.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,36E0M@31979|Clostridiaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_5315784_2	1304284.L21TH_2222	4.236e-28	114.0	2E34K@1|root,32Y4P@2|Bacteria,1VEWQ@1239|Firmicutes,24QJP@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5315784_0	1120746.CCNL01000017_gene2697	1.355e-41	158.0	COG1191@1|root,COG1191@2|Bacteria	2|Bacteria	K	sigma factor activity	sigI	-	-	ko:K03091,ko:K03093	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2
HKD1_k127_5323766_0	1304284.L21TH_2046	9.21e-112	372.0	COG0772@1|root,COG0772@2|Bacteria,1TPGH@1239|Firmicutes,247WS@186801|Clostridia,36EC8@31979|Clostridiaceae	186801|Clostridia	D	Belongs to the SEDS family	rodA	-	-	ko:K05837	-	-	-	-	ko00000,ko03036	-	-	-	FTSW_RODA_SPOVE
HKD1_k127_5323766_1	1408439.JHXW01000004_gene1382	7.592e-27	111.0	COG0482@1|root,COG0482@2|Bacteria,378H6@32066|Fusobacteria	32066|Fusobacteria	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	GO:0002097,GO:0002098,GO:0002143,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:1901360	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_5324680_1	1321778.HMPREF1982_04571	3.548e-24	104.0	COG0526@1|root,COG0526@2|Bacteria,1VFUD@1239|Firmicutes,24R4Y@186801|Clostridia	186801|Clostridia	CO	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin
HKD1_k127_5324680_0	1321778.HMPREF1982_00200	9.97e-120	389.0	COG1052@1|root,COG1052@2|Bacteria,1TPCX@1239|Firmicutes,248UR@186801|Clostridia	186801|Clostridia	CH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	1.1.1.215,1.1.1.26,1.1.1.79,1.1.1.81	ko:K00015,ko:K00090	ko00030,ko00260,ko00620,ko00630,ko01100,ko01110,ko01120,map00030,map00260,map00620,map00630,map01100,map01110,map01120	-	R00465,R00717,R01388,R01392,R01739	RC00031,RC00042,RC00084	ko00000,ko00001,ko01000	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_5326454_1	1128398.Curi_c03110	2.922e-13	72.0	COG0210@1|root,COG0210@2|Bacteria,1TPSU@1239|Firmicutes,247RM@186801|Clostridia,267U0@186813|unclassified Clostridiales	186801|Clostridia	L	UvrD-like helicase C-terminal domain	pcrA	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_5326454_0	755731.Clo1100_2331	1.896e-210	659.0	COG0272@1|root,COG0272@2|Bacteria,1TPQ3@1239|Firmicutes,248AX@186801|Clostridia,36EUE@31979|Clostridiaceae	186801|Clostridia	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2,HHH_5
HKD1_k127_5329433_0	1408422.JHYF01000012_gene3127	4.763e-313	969.0	COG0143@1|root,COG0143@2|Bacteria,1TPA1@1239|Firmicutes,248AU@186801|Clostridia,36E2T@31979|Clostridiaceae	186801|Clostridia	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g,tRNA_bind
HKD1_k127_5332097_0	398512.JQKC01000005_gene5519	4.731e-119	385.0	COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,3WN8G@541000|Ruminococcaceae	186801|Clostridia	P	Manganese containing catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
HKD1_k127_5332097_1	1304866.K413DRAFT_2004	7.214e-103	337.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,36DKP@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	cooS	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD1_k127_5337828_1	411469.EUBHAL_00513	1.262e-102	338.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,25URU@186806|Eubacteriaceae	186801|Clostridia	C	RnfC Barrel sandwich hybrid domain	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_17,RnfC_N,SLBB
HKD1_k127_5337828_0	397288.C806_00280	1.104e-200	630.0	COG1012@1|root,COG1012@2|Bacteria,1TRGK@1239|Firmicutes,2480V@186801|Clostridia,27IR2@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Aldehyde dehydrogenase family	-	-	1.2.1.87	ko:K13922	ko00640,map00640	-	R09097	RC00004,RC00184	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD1_k127_5338367_1	350688.Clos_0099	1.066e-65	230.0	COG5164@1|root,COG5164@2|Bacteria,1VFKD@1239|Firmicutes,24Z10@186801|Clostridia,36UP7@31979|Clostridiaceae	186801|Clostridia	K	Collagen triple helix repeat	-	-	-	-	-	-	-	-	-	-	-	-	Collagen
HKD1_k127_5338367_3	545243.BAEV01000087_gene2347	3.309e-45	179.0	COG0463@1|root,COG0463@2|Bacteria,1TQEM@1239|Firmicutes,249HH@186801|Clostridia,36EPG@31979|Clostridiaceae	186801|Clostridia	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2,TPR_8
HKD1_k127_5338367_2	86416.Clopa_3064	3.925e-63	232.0	COG0463@1|root,COG0463@2|Bacteria,1UI66@1239|Firmicutes,25EDR@186801|Clostridia,36UM9@31979|Clostridiaceae	186801|Clostridia	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD1_k127_5338367_0	858215.Thexy_0530	5.274e-164	522.0	COG0715@1|root,COG0715@2|Bacteria,1TRDC@1239|Firmicutes	1239|Firmicutes	P	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1
HKD1_k127_5338367_4	1305836.AXVE01000011_gene861	8.919e-10	62.0	COG0600@1|root,COG0600@2|Bacteria,1TQ26@1239|Firmicutes,4HABU@91061|Bacilli,26EIN@186818|Planococcaceae	91061|Bacilli	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02050,ko:K15554	ko00920,ko02010,map00920,map02010	M00188,M00436	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.16,3.A.1.17,3.A.1.17.2	-	-	BPD_transp_1
HKD1_k127_5356658_1	931626.Awo_c03860	4.941e-20	90.0	COG0695@1|root,COG0695@2|Bacteria,1UF2R@1239|Firmicutes,25NBW@186801|Clostridia,25Z45@186806|Eubacteriaceae	186801|Clostridia	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_5356658_0	1391647.AVSV01000036_gene906	1.303e-125	406.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36FIQ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	atzB	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD1_k127_5363699_0	931626.Awo_c09950	1.707e-24	106.0	COG3279@1|root,COG3279@2|Bacteria,1VBY3@1239|Firmicutes,24GY2@186801|Clostridia,25WXE@186806|Eubacteriaceae	186801|Clostridia	K	COG3279 Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HKD1_k127_5363699_1	936596.HMPREF1495_2515	4.341e-23	107.0	COG3290@1|root,COG3290@2|Bacteria,1V46S@1239|Firmicutes,24KBY@186801|Clostridia,1HUVH@1164882|Lachnoanaerobaculum	186801|Clostridia	T	GHKL domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c_5
HKD1_k127_5366192_0	1120998.AUFC01000048_gene3026	5.079e-64	225.0	COG2206@1|root,COG2206@2|Bacteria,1TQIM@1239|Firmicutes,248S5@186801|Clostridia	186801|Clostridia	T	PFAM metal-dependent phosphohydrolase, HD sub domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,HD_5
HKD1_k127_5374159_0	1347392.CCEZ01000043_gene444	5.263e-86	296.0	COG1686@1|root,COG1686@2|Bacteria,1TQ8M@1239|Firmicutes,2480S@186801|Clostridia,36DEG@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacB2	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_5374159_1	1094508.Tsac_1889	1.47e-53	193.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,248UG@186801|Clostridia,42G4B@68295|Thermoanaerobacterales	186801|Clostridia	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.19,5.4.99.22	ko:K06178,ko:K06183	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_5380886_0	1268072.PSAB_10075	2.119e-144	469.0	COG1653@1|root,COG1653@2|Bacteria,1VSE3@1239|Firmicutes,4IPP2@91061|Bacilli,2761A@186822|Paenibacillaceae	91061|Bacilli	G	Bacterial extracellular solute-binding protein	-	-	-	ko:K10117	ko02010,map02010	M00196	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.1.28	-	-	SBP_bac_8
HKD1_k127_5382758_0	1304284.L21TH_1646	2.829e-118	392.0	COG2244@1|root,COG2244@2|Bacteria,1TNYX@1239|Firmicutes,2485G@186801|Clostridia,36FTH@31979|Clostridiaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	ko:K06409	-	-	-	-	ko00000,ko02000	2.A.66.2.14	-	-	Polysacc_synt,Polysacc_synt_C
HKD1_k127_5383741_2	1304284.L21TH_0844	6.176e-52	188.0	COG1386@1|root,COG1386@2|Bacteria,1V6HI@1239|Firmicutes,24JW7@186801|Clostridia,36I39@31979|Clostridiaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD1_k127_5383741_3	1304284.L21TH_0843	5.625e-50	186.0	COG1354@1|root,COG1354@2|Bacteria,1TRW3@1239|Firmicutes,249VW@186801|Clostridia,36EKU@31979|Clostridiaceae	186801|Clostridia	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD1_k127_5383741_0	1121289.JHVL01000005_gene931	6.109e-102	344.0	COG1686@1|root,COG1686@2|Bacteria,1TQN0@1239|Firmicutes,249B3@186801|Clostridia,36FB8@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the peptidase S11 family	dacF	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD1_k127_5383741_1	1031288.AXAA01000007_gene861	1.192e-94	315.0	COG1015@1|root,COG1015@2|Bacteria,1TP70@1239|Firmicutes,247WB@186801|Clostridia,36E24@31979|Clostridiaceae	186801|Clostridia	G	Phosphotransfer between the C1 and C5 carbon atoms of pentose	deoB	-	5.4.2.7	ko:K01839	ko00030,ko00230,map00030,map00230	-	R01057,R02749	RC00408	ko00000,ko00001,ko01000	-	-	-	Metalloenzyme
HKD1_k127_5387218_0	332101.JIBU02000024_gene3252	0.0004987	51.0	2ECRX@1|root,336PJ@2|Bacteria,1VJAC@1239|Firmicutes,24RBA@186801|Clostridia,36K8E@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5390952_2	203119.Cthe_0665	1.118e-46	171.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,24AF9@186801|Clostridia,3WNDD@541000|Ruminococcaceae	186801|Clostridia	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_5390952_1	720554.Clocl_1454	2.292e-85	291.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,248MP@186801|Clostridia,3WH9Z@541000|Ruminococcaceae	186801|Clostridia	O	SPFH Band 7 PHB domain protein	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_5390952_3	1120746.CCNL01000011_gene1884	1.09e-14	79.0	296ME@1|root,2ZTWQ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5390952_0	857293.CAAU_0267	1.75e-103	344.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,248WN@186801|Clostridia,36FFK@31979|Clostridiaceae	186801|Clostridia	C	Na H antiporter	-	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
HKD1_k127_5396675_0	1280692.AUJL01000015_gene1220	1.147e-151	487.0	COG1362@1|root,COG1362@2|Bacteria,1TQ3Z@1239|Firmicutes,248UP@186801|Clostridia,36EV0@31979|Clostridiaceae	186801|Clostridia	E	M18 family aminopeptidase	apeB	-	3.4.11.21	ko:K01267	-	-	-	-	ko00000,ko01000,ko01002,ko04131	-	-	-	Peptidase_M18
HKD1_k127_54005_1	1356854.N007_13140	0.0003525	44.0	COG1516@1|root,COG1516@2|Bacteria,1VA8K@1239|Firmicutes,4HIN5@91061|Bacilli	91061|Bacilli	N	flagellar protein FliS	fliS	-	-	ko:K02422	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035	-	-	-	FliS
HKD1_k127_54005_0	720554.Clocl_1279	1.944e-54	193.0	COG2703@1|root,COG2703@2|Bacteria,1VAI0@1239|Firmicutes,24MQU@186801|Clostridia	186801|Clostridia	P	Hemerythrin HHE cation binding domain	-	-	-	ko:K07216	-	-	-	-	ko00000	-	-	-	Hemerythrin
HKD1_k127_5405018_0	1410653.JHVC01000007_gene513	1.738e-133	439.0	COG3973@1|root,COG3973@2|Bacteria,1TP39@1239|Firmicutes,249IG@186801|Clostridia,36E3M@31979|Clostridiaceae	186801|Clostridia	L	DNA helicase	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	AAA_19,UvrD-helicase,UvrD_C,UvrD_C_2
HKD1_k127_5405745_2	1304284.L21TH_1328	1.254e-66	236.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,36G12@31979|Clostridiaceae	186801|Clostridia	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD1_k127_5405745_0	1122947.FR7_3197	3.975e-128	418.0	COG0821@1|root,COG0821@2|Bacteria,1TPFR@1239|Firmicutes,4H2VM@909932|Negativicutes	909932|Negativicutes	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD1_k127_5405745_1	865861.AZSU01000006_gene1348	1.294e-97	328.0	COG1409@1|root,COG1409@2|Bacteria,1UQCQ@1239|Firmicutes,248P1@186801|Clostridia,36EPP@31979|Clostridiaceae	186801|Clostridia	F	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_5406058_1	1304284.L21TH_1986	4.356e-24	102.0	COG1573@1|root,COG1573@2|Bacteria,1V267@1239|Firmicutes,24DFW@186801|Clostridia,36EJT@31979|Clostridiaceae	186801|Clostridia	L	uracil-DNA glycosylase	udgA	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD1_k127_5406058_0	1121335.Clst_1950	1.156e-85	289.0	COG0692@1|root,COG0692@2|Bacteria,1UUFM@1239|Firmicutes,256M9@186801|Clostridia,3WR39@541000|Ruminococcaceae	186801|Clostridia	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	-	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	-
HKD1_k127_5409905_2	1304284.L21TH_1822	1.314e-16	82.0	COG1811@1|root,COG1811@2|Bacteria,1UH19@1239|Firmicutes,24AZ3@186801|Clostridia,36FKD@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF554)	-	-	-	ko:K07150	-	-	-	-	ko00000	-	-	-	DUF554
HKD1_k127_5409905_0	309799.DICTH_1342	9.519e-76	264.0	COG0313@1|root,COG0313@2|Bacteria	2|Bacteria	H	rRNA processing	rsmI	GO:0000154,GO:0000451,GO:0000453,GO:0001510,GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008173,GO:0008649,GO:0008757,GO:0009451,GO:0009987,GO:0010467,GO:0016020,GO:0016070,GO:0016072,GO:0016434,GO:0016740,GO:0016741,GO:0022613,GO:0031167,GO:0032259,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0043414,GO:0044085,GO:0044237,GO:0044238,GO:0044260,GO:0044464,GO:0046483,GO:0070677,GO:0071704,GO:0071840,GO:0071944,GO:0090304,GO:0140098,GO:0140102,GO:1901360	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD1_k127_5409905_1	350688.Clos_0979	7.975e-64	227.0	COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,36DC9@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD1_k127_541301_1	1304284.L21TH_1206	7.992e-135	436.0	COG0557@1|root,COG0557@2|Bacteria,1TQ1G@1239|Firmicutes,247ZS@186801|Clostridia,36E8U@31979|Clostridiaceae	186801|Clostridia	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	OB_RNB,RNB,S1
HKD1_k127_541301_2	1304284.L21TH_1204	7.946e-64	222.0	COG0691@1|root,COG0691@2|Bacteria,1V3IJ@1239|Firmicutes,24HD6@186801|Clostridia,36HZ8@31979|Clostridiaceae	186801|Clostridia	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD1_k127_541301_4	1449050.JNLE01000003_gene1027	2.008e-10	61.0	COG2801@1|root,COG2801@2|Bacteria,1TU21@1239|Firmicutes,24DGQ@186801|Clostridia,36E9G@31979|Clostridiaceae	186801|Clostridia	L	PFAM Integrase catalytic region	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,HTH_Tnp_1,rve,rve_3
HKD1_k127_541301_3	1449063.JMLS01000011_gene289	5.295e-33	130.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,4HAIK@91061|Bacilli,26QTC@186822|Paenibacillaceae	91061|Bacilli	S	Peptidase dimerisation domain	-	-	-	ko:K21613	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5415474_3	1347392.CCEZ01000004_gene754	1.659e-13	74.0	COG2843@1|root,COG2843@2|Bacteria,1UZW4@1239|Firmicutes,24950@186801|Clostridia,36WWA@31979|Clostridiaceae	186801|Clostridia	M	Bacterial capsule synthesis protein PGA_cap	capA	-	-	ko:K07282	-	-	-	-	ko00000	-	-	-	PGA_cap
HKD1_k127_5415474_0	1128398.Curi_c21890	1.67e-87	297.0	COG1624@1|root,COG1624@2|Bacteria,1TPRW@1239|Firmicutes,249K8@186801|Clostridia,268WQ@186813|unclassified Clostridiales	186801|Clostridia	S	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria	dacA	-	2.7.7.85	ko:K18672	-	-	-	-	ko00000,ko01000	-	-	-	DisA_N
HKD1_k127_5415474_2	553973.CLOHYLEM_04632	9.425e-21	106.0	COG4856@1|root,COG4856@2|Bacteria,1UZEV@1239|Firmicutes,25CGI@186801|Clostridia,22492@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	YbbR
HKD1_k127_5415474_1	1304284.L21TH_2285	5.507e-32	128.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
HKD1_k127_5416285_0	1120746.CCNL01000012_gene1913	8.085e-245	761.0	COG0535@1|root,COG0535@2|Bacteria,2NQMX@2323|unclassified Bacteria	2|Bacteria	S	4Fe-4S single cluster domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,SPASM
HKD1_k127_5421948_0	742741.HMPREF9475_00516	5.366e-180	572.0	COG1593@1|root,COG1593@2|Bacteria,1TSR1@1239|Firmicutes	1239|Firmicutes	G	Tripartite ATP-independent periplasmic transporter, DctM component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_5425374_2	1131462.DCF50_p199	1.289e-55	196.0	2DMHQ@1|root,32RMG@2|Bacteria,1VB95@1239|Firmicutes,24K45@186801|Clostridia,26204@186807|Peptococcaceae	186801|Clostridia	S	Arsenical resistance operon trans-acting repressor ArsD	arsD	-	-	-	-	-	-	-	-	-	-	-	ArsD
HKD1_k127_5425374_4	755731.Clo1100_3495	5.529e-36	139.0	COG0640@1|root,COG0640@2|Bacteria,1V9KK@1239|Firmicutes,24NXW@186801|Clostridia,36JM8@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	-	-	-	ko:K03892	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_5425374_1	1291050.JAGE01000001_gene1123	1.266e-175	556.0	COG0798@1|root,COG0798@2|Bacteria,1TRMD@1239|Firmicutes,24958@186801|Clostridia,3WIBW@541000|Ruminococcaceae	186801|Clostridia	P	TIGRFAM arsenical-resistance protein	arsB	-	-	ko:K03325	-	-	-	-	ko00000,ko02000	2.A.59	-	-	SBF
HKD1_k127_5425374_3	350688.Clos_1115	1.103e-40	154.0	COG0607@1|root,COG0607@2|Bacteria	2|Bacteria	P	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	yrkH	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD1_k127_5425374_0	755731.Clo1100_3492	6.778e-310	956.0	COG0003@1|root,COG0003@2|Bacteria,1TQZP@1239|Firmicutes,249JN@186801|Clostridia,36EXQ@31979|Clostridiaceae	186801|Clostridia	D	TIGRFAM arsenite-activated ATPase ArsA	arsA	-	3.6.3.16	ko:K01551	-	-	-	-	ko00000,ko01000,ko02000	3.A.19.1,3.A.21.1,3.A.4.1	-	-	ArsA_ATPase
HKD1_k127_5426113_0	665956.HMPREF1032_00456	3.416e-154	499.0	COG0534@1|root,COG0534@2|Bacteria,1TNZN@1239|Firmicutes,247YX@186801|Clostridia,3WH49@541000|Ruminococcaceae	186801|Clostridia	V	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_5426113_1	1286171.EAL2_c09020	2.431e-27	113.0	COG0137@1|root,COG0137@2|Bacteria,1TP3X@1239|Firmicutes,247MF@186801|Clostridia,25UVK@186806|Eubacteriaceae	186801|Clostridia	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD1_k127_5434978_0	656519.Halsa_0523	4.567e-151	494.0	COG1292@1|root,COG1292@2|Bacteria,1TRS6@1239|Firmicutes,2482K@186801|Clostridia,3WB9Q@53433|Halanaerobiales	186801|Clostridia	P	Belongs to the BCCT transporter (TC 2.A.15) family	-	-	-	-	-	-	-	-	-	-	-	-	BCCT
HKD1_k127_5434978_1	1507.HMPREF0262_00983	7.624e-57	208.0	COG0477@1|root,COG2814@2|Bacteria,1TS6K@1239|Firmicutes,24AKU@186801|Clostridia,36DGS@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator	tetA	-	-	ko:K08151,ko:K08153	-	M00668,M00717	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.2.38,2.A.1.2.39,2.A.1.2.4,2.A.1.2.41,2.A.1.2.68,2.A.1.2.75,2.A.1.2.8	-	-	MFS_1,MFS_1_like,Sugar_tr
HKD1_k127_5442022_1	1304284.L21TH_0879	1.641e-51	188.0	COG2715@1|root,COG2715@2|Bacteria,1V1E2@1239|Firmicutes,249G0@186801|Clostridia,36E11@31979|Clostridiaceae	186801|Clostridia	S	Spore maturation protein	spmA	-	-	ko:K06373	-	-	-	-	ko00000	-	-	-	Gate
HKD1_k127_5442022_2	1304284.L21TH_0880	2.49e-49	181.0	COG0700@1|root,COG0700@2|Bacteria,1V45M@1239|Firmicutes,24HSJ@186801|Clostridia,36HZ1@31979|Clostridiaceae	186801|Clostridia	S	Spore maturation protein	spmB	-	-	ko:K06374	-	-	-	-	ko00000	-	-	-	Gate
HKD1_k127_5442022_0	536227.CcarbDRAFT_4776	5.232e-87	294.0	COG1296@1|root,COG1296@2|Bacteria,1TP8P@1239|Firmicutes,248NN@186801|Clostridia,36HC0@31979|Clostridiaceae	186801|Clostridia	E	branched-chain amino acid permease (azaleucine resistance)	-	-	-	-	-	-	-	-	-	-	-	-	AzlC
HKD1_k127_5442022_3	756499.Desde_2976	6.783e-06	49.0	COG1687@1|root,COG1687@2|Bacteria,1V9YS@1239|Firmicutes,24MSG@186801|Clostridia,2661Q@186807|Peptococcaceae	186801|Clostridia	E	branched-chain amino acid	azlD	-	-	-	-	-	-	-	-	-	-	-	AzlD
HKD1_k127_5444255_0	1211817.CCAT010000064_gene797	2.67e-119	393.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,36F3D@31979|Clostridiaceae	186801|Clostridia	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_5444470_2	1121472.AQWN01000001_gene86	1.372e-25	110.0	COG5015@1|root,COG5015@2|Bacteria,1V4P5@1239|Firmicutes,25D0I@186801|Clostridia,262KN@186807|Peptococcaceae	186801|Clostridia	S	PFAM pyridoxamine 5'-phosphate	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD1_k127_5444470_0	86416.Clopa_4665	3.45e-143	462.0	COG2876@1|root,COG2876@2|Bacteria,1TP61@1239|Firmicutes,24812@186801|Clostridia,36FA1@31979|Clostridiaceae	186801|Clostridia	E	phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	-	2.5.1.54	ko:K03856	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R01826	RC00435	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14395	DAHP_synth_1
HKD1_k127_5444470_1	386415.NT01CX_0621	1.538e-106	351.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,36E3G@31979|Clostridiaceae	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS14365	CM_2,SKI,Shikimate_DH,Shikimate_dh_N
HKD1_k127_5447933_0	552398.HMPREF0866_01169	5.764e-73	254.0	COG0697@1|root,COG0697@2|Bacteria,1W764@1239|Firmicutes,25MS9@186801|Clostridia,3WQZJ@541000|Ruminococcaceae	186801|Clostridia	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_5449465_0	1121289.JHVL01000062_gene264	1.57e-68	246.0	COG0457@1|root,COG0457@2|Bacteria,1V96X@1239|Firmicutes,24AK3@186801|Clostridia,36DG6@31979|Clostridiaceae	186801|Clostridia	S	repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_2,TPR_8
HKD1_k127_5449836_0	641107.CDLVIII_3244	4.272e-65	228.0	COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,36DHY@31979|Clostridiaceae	186801|Clostridia	J	elongation factor G	tetP	-	-	-	-	-	-	-	-	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP
HKD1_k127_5463075_0	469618.FVAG_01375	3.918e-104	344.0	COG1101@1|root,COG1101@2|Bacteria,379V6@32066|Fusobacteria	32066|Fusobacteria	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
HKD1_k127_5463075_1	1304284.L21TH_2709	2.409e-12	68.0	COG1956@1|root,COG1956@2|Bacteria,1V6GQ@1239|Firmicutes,24J9S@186801|Clostridia,36IYQ@31979|Clostridiaceae	186801|Clostridia	T	GAF domain	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF,GAF_2
HKD1_k127_5463511_0	272563.CD630_27690	3.513e-112	374.0	COG1086@1|root,COG1086@2|Bacteria,1TR3W@1239|Firmicutes,247PW@186801|Clostridia,25QVY@186804|Peptostreptococcaceae	186801|Clostridia	GM	CoA-binding domain	capD	-	-	-	-	-	-	-	-	-	-	-	CoA_binding_3,Polysacc_synt_2
HKD1_k127_5469560_0	97138.C820_00486	8.433e-119	391.0	COG0039@1|root,COG0039@2|Bacteria,1TQIV@1239|Firmicutes,248DK@186801|Clostridia,36GJF@31979|Clostridiaceae	186801|Clostridia	C	lactate/malate dehydrogenase, NAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Ldh_1_N
HKD1_k127_5469560_1	1304284.L21TH_0081	4.617e-114	378.0	COG0431@1|root,COG0431@2|Bacteria,1UYKJ@1239|Firmicutes,2485E@186801|Clostridia,36E7N@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_5482338_0	1304284.L21TH_1091	4.488e-140	451.0	COG0469@1|root,COG0469@2|Bacteria,1TPGG@1239|Firmicutes,2489V@186801|Clostridia,36DIR@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PEP-utilizers,PK,PK_C
HKD1_k127_5494461_1	994573.T472_0209345	5.833e-43	158.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_5494461_0	994573.T472_0209350	1.759e-198	626.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248IH@186801|Clostridia,36WQV@31979|Clostridiaceae	186801|Clostridia	S	ABC-type transport system, periplasmic component surface lipoprotein	-	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD1_k127_5494461_2	596330.HMPREF0628_1428	1.162e-36	140.0	COG0151@1|root,COG0151@2|Bacteria,1UHN9@1239|Firmicutes,25E76@186801|Clostridia,22GVY@1570339|Peptoniphilaceae	186801|Clostridia	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD1_k127_5495397_0	1391646.AVSU01000056_gene1289	8.734e-33	139.0	COG3359@1|root,COG3359@2|Bacteria,1U725@1239|Firmicutes,24A9V@186801|Clostridia,25RYT@186804|Peptostreptococcaceae	186801|Clostridia	L	Predicted 3'-5' exonuclease related to the exonuclease domain of PolB	-	-	-	ko:K07502	-	-	-	-	ko00000	-	-	-	RNase_H_2
HKD1_k127_5495798_1	1235835.C814_00594	4.851e-17	89.0	28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,24GSB@186801|Clostridia,3WHJM@541000|Ruminococcaceae	186801|Clostridia	S	DHHW protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHW
HKD1_k127_5495798_0	445973.CLOBAR_01391	5.229e-151	491.0	COG1696@1|root,COG1696@2|Bacteria,1TP52@1239|Firmicutes,248V4@186801|Clostridia,25SYZ@186804|Peptostreptococcaceae	186801|Clostridia	M	MBOAT, membrane-bound O-acyltransferase family	-	-	-	ko:K19294	-	-	-	-	ko00000	-	-	-	MBOAT
HKD1_k127_5495877_3	875454.BAEW01000004_gene820	3.17e-42	160.0	COG0319@1|root,COG0319@2|Bacteria,1V6BU@1239|Firmicutes,24MQZ@186801|Clostridia,22HPP@1570339|Peptoniphilaceae	186801|Clostridia	S	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	3.5.4.5	ko:K01489,ko:K07042	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01878,R02485,R08221	RC00074,RC00514	ko00000,ko00001,ko01000,ko03009	-	-	-	UPF0054
HKD1_k127_5495877_1	1121289.JHVL01000002_gene2342	1.325e-121	398.0	COG1702@1|root,COG1702@2|Bacteria,1TP35@1239|Firmicutes,247ZJ@186801|Clostridia,36UI2@31979|Clostridiaceae	186801|Clostridia	T	PhoH-like protein	phoH	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD1_k127_5495877_7	935845.JADQ01000008_gene1861	4.113e-18	97.0	COG0561@1|root,COG0561@2|Bacteria,1TR3N@1239|Firmicutes,4HC8P@91061|Bacilli,26S3Y@186822|Paenibacillaceae	91061|Bacilli	S	sporulation protein	yqfD	-	-	ko:K06438	-	-	-	-	ko00000	-	-	-	YqfD
HKD1_k127_5495877_8	857293.CAAU_0503	2.343e-07	56.0	2E4EZ@1|root,32ZA5@2|Bacteria,1VF5C@1239|Firmicutes,24QWJ@186801|Clostridia,36MN2@31979|Clostridiaceae	186801|Clostridia	S	sporulation protein YqfC	yqfC	-	-	-	-	-	-	-	-	-	-	-	YabP
HKD1_k127_5495877_2	1128398.Curi_c18200	1.71e-52	188.0	COG1610@1|root,COG1610@2|Bacteria,1V6F2@1239|Firmicutes,24JB0@186801|Clostridia,269AX@186813|unclassified Clostridiales	186801|Clostridia	S	Yqey-like protein	yqeY	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD1_k127_5495877_6	1408823.AXUS01000003_gene480	5.131e-21	94.0	COG0828@1|root,COG0828@2|Bacteria,1VEHU@1239|Firmicutes,24QP9@186801|Clostridia	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD1_k127_5495877_4	1211817.CCAT010000003_gene298	5.835e-37	142.0	COG0537@1|root,COG0537@2|Bacteria,1V9ZJ@1239|Firmicutes,24JCW@186801|Clostridia,36JIP@31979|Clostridiaceae	186801|Clostridia	FG	Hit family	hinT	-	-	ko:K02503	-	-	-	-	ko00000,ko04147	-	-	-	HIT
HKD1_k127_5495877_0	1410653.JHVC01000009_gene2832	2.354e-130	430.0	COG0621@1|root,COG0621@2|Bacteria,1TPBR@1239|Firmicutes,247IX@186801|Clostridia,36DS5@31979|Clostridiaceae	186801|Clostridia	J	MiaB-like tRNA modifying enzyme	yqeV	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_5495877_5	1216932.CM240_1723	4.107e-21	94.0	COG0792@1|root,COG0792@2|Bacteria,1VFHQ@1239|Firmicutes,24QNK@186801|Clostridia,36MV2@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the UPF0102 family	-	-	-	ko:K07460	-	-	-	-	ko00000	-	-	-	UPF0102
HKD1_k127_5497613_1	1120998.AUFC01000036_gene1297	7.104e-31	123.0	COG1937@1|root,COG1937@2|Bacteria	2|Bacteria	S	negative regulation of transcription, DNA-templated	csoR	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD1_k127_5497613_0	944546.ABED_0456	4.673e-84	284.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,42M2R@68525|delta/epsilon subdivisions,2YMM8@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	P	cation transport ATPase	copA	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	3.6.3.4,3.6.3.54	ko:K01533,ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_5497667_0	1007096.BAGW01000006_gene1808	1.022e-141	473.0	COG0840@1|root,COG2972@1|root,COG0840@2|Bacteria,COG2972@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,2N7Y3@216572|Oscillospiraceae	186801|Clostridia	NT	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer).	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal,dCache_1
HKD1_k127_5497667_1	1216932.CM240_2996	3.335e-09	57.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD1_k127_5499075_6	666686.B1NLA3E_11125	8.507e-30	124.0	COG5401@1|root,COG5401@2|Bacteria,1TQX6@1239|Firmicutes,4HIBN@91061|Bacilli	91061|Bacilli	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HKD1_k127_5499075_3	1414720.CBYM010000006_gene1228	1.498e-81	276.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,36DD1@31979|Clostridiaceae	186801|Clostridia	F	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_5499075_5	641107.CDLVIII_0481	1.416e-61	216.0	COG1418@1|root,COG1418@2|Bacteria,1VBWP@1239|Firmicutes,24JJV@186801|Clostridia,36JH9@31979|Clostridiaceae	186801|Clostridia	S	SMART Metal-dependent phosphohydrolase, HD region	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD1_k127_5499075_0	290402.Cbei_0206	1.26e-126	410.0	COG0294@1|root,COG0294@2|Bacteria,1TPKT@1239|Firmicutes,248BE@186801|Clostridia,36EFV@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03115	Pterin_bind
HKD1_k127_5499075_1	1345695.CLSA_c02610	1.752e-117	383.0	COG0801@1|root,COG1539@1|root,COG0801@2|Bacteria,COG1539@2|Bacteria,1V6PR@1239|Firmicutes,249YP@186801|Clostridia,36ECT@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin	folK	-	2.7.6.3,4.1.2.25	ko:K00950,ko:K13940	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503,R03504	RC00002,RC00017,RC00721,RC00943	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB,HPPK
HKD1_k127_5499075_2	350688.Clos_2372	4.493e-86	297.0	COG0628@1|root,COG0628@2|Bacteria,1TS4S@1239|Firmicutes,248E5@186801|Clostridia,36FRI@31979|Clostridiaceae	186801|Clostridia	S	sporulation integral membrane protein YtvI	ytvI	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_5499075_4	1511.CLOST_2045	8.392e-63	221.0	COG1272@1|root,COG1272@2|Bacteria,1TSFK@1239|Firmicutes,24CPT@186801|Clostridia,25R01@186804|Peptostreptococcaceae	186801|Clostridia	S	Channel protein, hemolysin III family	yqfA	-	-	ko:K11068	-	-	-	-	ko00000,ko02042	-	-	-	HlyIII
HKD1_k127_5500779_1	1487921.DP68_05210	9.299e-42	163.0	COG0834@1|root,COG4191@1|root,COG0834@2|Bacteria,COG4191@2|Bacteria,1TSVK@1239|Firmicutes,24CCA@186801|Clostridia,36HB1@31979|Clostridiaceae	186801|Clostridia	T	Bacterial periplasmic substrate-binding proteins	-	-	-	ko:K02030	-	M00236	-	-	ko00000,ko00002,ko02000	3.A.1.3	-	-	HATPase_c,HisKA,PAS_9,SBP_bac_3
HKD1_k127_5500779_0	1487921.DP68_05215	1.707e-135	445.0	COG2204@1|root,COG2204@2|Bacteria,1VSKG@1239|Firmicutes,24ZP4@186801|Clostridia,36EVK@31979|Clostridiaceae	186801|Clostridia	T	Two component, sigma54 specific, transcriptional regulator, Fis family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PEP_hydrolase,Response_reg,Sigma54_activat
HKD1_k127_5501753_1	1009370.ALO_07498	2.743e-64	226.0	COG3758@1|root,COG3758@2|Bacteria,1VH52@1239|Firmicutes,4H5SD@909932|Negativicutes	909932|Negativicutes	S	HutD	-	-	-	-	-	-	-	-	-	-	-	-	HutD
HKD1_k127_5501753_0	1354300.AUQY01000003_gene536	7.889e-136	437.0	COG3643@1|root,COG3643@2|Bacteria,1UYYH@1239|Firmicutes,24FG1@186801|Clostridia	186801|Clostridia	E	Formiminotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	FTCD,FTCD_N
HKD1_k127_5501753_2	1487921.DP68_15025	3.205e-56	201.0	COG3404@1|root,COG3404@2|Bacteria,1VVEM@1239|Firmicutes,24JAH@186801|Clostridia,36MEE@31979|Clostridiaceae	186801|Clostridia	E	Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
HKD1_k127_5502106_0	1123009.AUID01000016_gene49	6.25e-146	467.0	COG1477@1|root,COG1477@2|Bacteria,1TR9C@1239|Firmicutes,248KJ@186801|Clostridia,268UZ@186813|unclassified Clostridiales	186801|Clostridia	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	apbE	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD1_k127_5504699_0	1292035.H476_3007	3.458e-138	464.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
HKD1_k127_5504847_0	1304284.L21TH_1500	8.312e-69	246.0	COG0668@1|root,COG0668@2|Bacteria,1TR9Z@1239|Firmicutes,24CAG@186801|Clostridia,36EG8@31979|Clostridiaceae	186801|Clostridia	M	mechanosensitive ion channel	-	-	-	ko:K16052	-	-	-	-	ko00000,ko02000	1.A.23.4	-	-	MS_channel
HKD1_k127_5505027_1	203119.Cthe_3013	1.068e-63	220.0	COG0309@1|root,COG0309@2|Bacteria,1TQP4@1239|Firmicutes,24963@186801|Clostridia,3WGZN@541000|Ruminococcaceae	186801|Clostridia	O	hydrogenase expression formation protein HypE	hypE	-	-	ko:K04655	-	-	-	-	ko00000	-	-	-	AIRS,AIRS_C
HKD1_k127_5505027_0	37659.JNLN01000001_gene9	1.503e-234	737.0	COG1164@1|root,COG1164@2|Bacteria,1TPV4@1239|Firmicutes,2495D@186801|Clostridia,36ET0@31979|Clostridiaceae	186801|Clostridia	E	oligoendopeptidase, M3 family	pz-A	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M3
HKD1_k127_5511525_1	871968.DESME_07730	3.853e-21	94.0	COG1977@1|root,COG1977@2|Bacteria,1VIST@1239|Firmicutes,24QYP@186801|Clostridia	186801|Clostridia	H	ThiS family	moaD	-	-	-	-	-	-	-	-	-	-	-	ThiS
HKD1_k127_5511525_0	913865.DOT_3395	1.834e-85	288.0	COG0476@1|root,COG0476@2|Bacteria,1TQ3U@1239|Firmicutes,25CJC@186801|Clostridia,263VD@186807|Peptococcaceae	186801|Clostridia	H	Dinucleotide-utilizing enzyme possibly involved in molybdopterin or thiamin biosynthesis	moeB	-	-	-	-	-	-	-	-	-	-	-	ThiF
HKD1_k127_5514250_0	1120746.CCNL01000014_gene2065	5.86e-68	242.0	COG0598@1|root,COG0598@2|Bacteria	2|Bacteria	P	Magnesium transport protein CorA	corA	GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0016020,GO:0016021,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD1_k127_5516606_2	357809.Cphy_3296	2.227e-11	70.0	28HHD@1|root,2Z7T3@2|Bacteria,1TRKJ@1239|Firmicutes,24A0Y@186801|Clostridia,21Y7N@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF3810)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3810
HKD1_k127_5516606_1	1121091.AUMP01000010_gene1109	1.543e-77	267.0	COG5577@1|root,COG5577@2|Bacteria,1V1SJ@1239|Firmicutes,4HG3B@91061|Bacilli	91061|Bacilli	M	Spore Coat Protein	-	-	-	-	-	-	-	-	-	-	-	-	Coat_F
HKD1_k127_5516606_0	1499689.CCNN01000006_gene541	3.015e-92	308.0	COG2066@1|root,COG2066@2|Bacteria,1TP64@1239|Firmicutes,2491K@186801|Clostridia,36EFX@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the glutaminase family	glsA	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
HKD1_k127_5516861_1	269797.Mbar_A0770	2.723e-23	100.0	COG0716@1|root,arCOG00519@2157|Archaea,2XXH8@28890|Euryarchaeota,2NADI@224756|Methanomicrobia	224756|Methanomicrobia	C	Flavodoxin	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
HKD1_k127_5516861_0	641107.CDLVIII_2548	2.266e-111	362.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,36E3H@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_5526281_1	1274524.BSONL12_21364	1.109e-11	72.0	2BFNE@1|root,329GT@2|Bacteria,1UBVU@1239|Firmicutes,4INBE@91061|Bacilli,1ZN6Q@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5526281_0	224308.BSU21150	3.395e-48	186.0	29SKI@1|root,30DRU@2|Bacteria,1UBM9@1239|Firmicutes,4IN1J@91061|Bacilli,1ZMIW@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5527281_3	1235798.C817_00894	1.114e-130	426.0	COG0006@1|root,COG0006@2|Bacteria,1TQ44@1239|Firmicutes,247SG@186801|Clostridia	186801|Clostridia	E	creatinase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD1_k127_5527281_1	1232452.BAIB02000008_gene1899	4.219e-142	456.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,268KP@186813|unclassified Clostridiales	186801|Clostridia	EP	Binding-protein-dependent transport system inner membrane component	oppB	-	-	ko:K15581	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1
HKD1_k127_5527281_4	1232452.BAIB02000008_gene1898	7.304e-130	422.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,267WJ@186813|unclassified Clostridiales	186801|Clostridia	EP	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K02034,ko:K15582	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	BPD_transp_1,OppC_N
HKD1_k127_5527281_0	1232452.BAIB02000008_gene1897	1.138e-153	492.0	COG0444@1|root,COG0444@2|Bacteria,1TP6E@1239|Firmicutes,247NN@186801|Clostridia,2689V@186813|unclassified Clostridiales	186801|Clostridia	EP	Oligopeptide/dipeptide transporter, C-terminal region	oppD	-	-	ko:K15583	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_5527281_2	1232452.BAIB02000008_gene1896	1.826e-133	430.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,267P6@186813|unclassified Clostridiales	186801|Clostridia	E	ABC transporter, ATP-binding protein	-	-	-	ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_5535165_0	1120998.AUFC01000003_gene1485	3.116e-238	749.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
HKD1_k127_5536968_1	646529.Desaci_1504	6.805e-07	52.0	COG3760@1|root,COG3760@2|Bacteria,1V1JF@1239|Firmicutes,24FVD@186801|Clostridia	186801|Clostridia	J	YbaK proline--tRNA ligase associated domain protein	-	-	-	ko:K19055	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_5536968_0	1123009.AUID01000009_gene496	6.81e-115	378.0	COG0038@1|root,COG0569@1|root,COG0038@2|Bacteria,COG0569@2|Bacteria,1TPX0@1239|Firmicutes,247R4@186801|Clostridia,26826@186813|unclassified Clostridiales	186801|Clostridia	P	Voltage gated chloride channel	clcA	-	-	-	-	-	-	-	-	-	-	-	TrkA_C,Voltage_CLC
HKD1_k127_5538013_1	1347392.CCEZ01000011_gene2467	3.837e-110	358.0	COG0172@1|root,COG0172@2|Bacteria,1TP4W@1239|Firmicutes,2485M@186801|Clostridia,36DP4@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD1_k127_5538013_0	1121090.KB894688_gene1819	7.578e-114	382.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,4HC5M@91061|Bacilli,1ZB0M@1386|Bacillus	91061|Bacilli	KT	COG3829 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_4,Sigma54_activat
HKD1_k127_5544160_1	1033734.CAET01000027_gene785	7.944e-10	60.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,4H9YB@91061|Bacilli,1ZBA4@1386|Bacillus	91061|Bacilli	E	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_5544160_0	350688.Clos_1345	1.834e-132	430.0	COG4608@1|root,COG4608@2|Bacteria,1V36J@1239|Firmicutes,24C3R@186801|Clostridia,36EGD@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the ABC transporter superfamily	appF	-	-	ko:K02032,ko:K10823	ko01501,ko02010,ko02024,map01501,map02010,map02024	M00239,M00439	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5,3.A.1.5.1,3.A.1.5.18,3.A.1.5.19,3.A.1.5.25	-	-	ABC_tran,oligo_HPY
HKD1_k127_5544160_2	218284.CCDN010000005_gene3340	2.891e-08	54.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,1ZHSU@1386|Bacillus	91061|Bacilli	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_5549759_2	293826.Amet_0166	2.177e-09	59.0	COG1188@1|root,COG1188@2|Bacteria,1VEI5@1239|Firmicutes,24QNF@186801|Clostridia,36KQU@31979|Clostridiaceae	186801|Clostridia	J	S4 domain protein	hslR	-	-	-	-	-	-	-	-	-	-	-	S4
HKD1_k127_5549759_1	588581.Cpap_3051	1.72e-82	277.0	COG1592@1|root,COG1592@2|Bacteria,1V1FF@1239|Firmicutes,248V2@186801|Clostridia,3WGRG@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	rbr	-	-	-	-	-	-	-	-	-	-	-	Rubrerythrin
HKD1_k127_5549759_0	1235799.C818_01598	1.834e-206	651.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,27IAZ@186928|unclassified Lachnospiraceae	186801|Clostridia	E	Argininosuccinate lyase C-terminal	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_5550823_0	931626.Awo_c03270	5.625e-186	586.0	COG1541@1|root,COG1541@2|Bacteria,1TQA1@1239|Firmicutes,248G9@186801|Clostridia,25VPD@186806|Eubacteriaceae	186801|Clostridia	H	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)	paaK	-	6.2.1.30	ko:K01912	ko00360,ko01120,ko05111,map00360,map01120,map05111	-	R02539	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C_2
HKD1_k127_5550823_1	903814.ELI_0969	1.883e-29	122.0	COG4747@1|root,COG4747@2|Bacteria,1V7U2@1239|Firmicutes,24JE5@186801|Clostridia,25WXA@186806|Eubacteriaceae	186801|Clostridia	S	ACT domain protein	-	-	-	-	-	-	-	-	-	-	-	-	ACT
HKD1_k127_5555880_1	1121324.CLIT_20p00160	1.233e-09	61.0	2DR42@1|root,33A2M@2|Bacteria,1VKCM@1239|Firmicutes,24UF3@186801|Clostridia	186801|Clostridia	S	Protein of unknown function (DUF2922)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2922
HKD1_k127_5555880_0	1408287.AXUR01000015_gene547	8.595e-90	302.0	COG3048@1|root,COG3048@2|Bacteria,379EP@32066|Fusobacteria	32066|Fusobacteria	E	Pyridoxal-phosphate dependent enzyme	dsdA	-	4.3.1.18	ko:K01753	ko00260,map00260	-	R00221	RC02600	ko00000,ko00001,ko01000	-	-	-	PALP
HKD1_k127_5567392_1	1128398.Curi_c25450	2.355e-74	256.0	COG0564@1|root,COG0564@2|Bacteria,1TX59@1239|Firmicutes,24HTV@186801|Clostridia,269PV@186813|unclassified Clostridiales	186801|Clostridia	J	RNA pseudouridylate synthase	rluC2	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD1_k127_5567392_0	1123009.AUID01000015_gene2042	2.083e-105	357.0	COG1167@1|root,COG1167@2|Bacteria,1TPS5@1239|Firmicutes,248ZB@186801|Clostridia,268JT@186813|unclassified Clostridiales	186801|Clostridia	K	helix_turn_helix gluconate operon transcriptional repressor	-	-	-	ko:K00375	-	-	-	-	ko00000,ko03000	-	-	-	Aminotran_1_2,GntR
HKD1_k127_5574081_0	1120746.CCNL01000017_gene2571	2.252e-160	512.0	COG1104@1|root,COG1104@2|Bacteria	2|Bacteria	E	Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins	iscS2	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_5574081_1	1120746.CCNL01000017_gene2572	9.383e-101	331.0	COG0037@1|root,COG0037@2|Bacteria,2NRHD@2323|unclassified Bacteria	2|Bacteria	D	PP-loop family	ttcA	GO:0003674,GO:0003824,GO:0005488,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006396,GO:0006399,GO:0006400,GO:0006725,GO:0006807,GO:0008033,GO:0008150,GO:0008152,GO:0009451,GO:0009987,GO:0010467,GO:0016070,GO:0016740,GO:0016782,GO:0016783,GO:0034227,GO:0034470,GO:0034641,GO:0034660,GO:0043170,GO:0043412,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0048037,GO:0051536,GO:0051539,GO:0051540,GO:0071704,GO:0090304,GO:1901360	6.3.4.19	ko:K04075,ko:K14058	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
HKD1_k127_5585309_0	1321778.HMPREF1982_04388	4.719e-100	329.0	COG2818@1|root,COG2818@2|Bacteria,1UYWG@1239|Firmicutes,249EP@186801|Clostridia,26ADH@186813|unclassified Clostridiales	186801|Clostridia	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD1_k127_5618929_1	1284708.HMPREF1634_02895	0.0003059	46.0	COG0206@1|root,COG0206@2|Bacteria,1TP6W@1239|Firmicutes,247Z5@186801|Clostridia,3WCEE@538999|Clostridiales incertae sedis	186801|Clostridia	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD1_k127_5618929_0	642492.Clole_1920	8.416e-277	857.0	COG0488@1|root,COG0488@2|Bacteria,1TPW0@1239|Firmicutes,248ST@186801|Clostridia	186801|Clostridia	S	ABC transporter	ykpA	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_5635181_0	1220589.CD32_14095	1.533e-29	123.0	COG0398@1|root,COG0398@2|Bacteria,1TS5T@1239|Firmicutes,4HDKU@91061|Bacilli,3IWZ7@400634|Lysinibacillus	91061|Bacilli	S	SNARE associated Golgi protein	yhjE	-	-	-	-	-	-	-	-	-	-	-	SNARE_assoc
HKD1_k127_5635181_2	1123248.KB893337_gene2403	6.192e-16	84.0	COG1514@1|root,COG1514@2|Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD1_k127_5635181_1	931626.Awo_c23790	1.204e-16	79.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,25UTX@186806|Eubacteriaceae	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_5637974_1	645991.Sgly_2919	4.472e-46	174.0	COG1994@1|root,COG1994@2|Bacteria,1V6D4@1239|Firmicutes,24K0D@186801|Clostridia,262K4@186807|Peptococcaceae	186801|Clostridia	S	PFAM peptidase	ywhC	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD1_k127_5637974_0	1121335.Clst_1572	2.929e-180	574.0	COG1253@1|root,COG1253@2|Bacteria,1TPN0@1239|Firmicutes,2489N@186801|Clostridia,3WGJP@541000|Ruminococcaceae	186801|Clostridia	S	CBS domain	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD1_k127_5643245_0	588581.Cpap_1239	9.431e-277	870.0	COG0714@1|root,COG1112@1|root,COG0714@2|Bacteria,COG1112@2|Bacteria,1TP20@1239|Firmicutes,24BMH@186801|Clostridia,3WHBK@541000|Ruminococcaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_11,AAA_12,DUF2726,DUF3320,DUF4011,DUF559
HKD1_k127_5643245_3	469617.FUAG_02712	5.84e-112	370.0	COG0491@1|root,COG0491@2|Bacteria,379AZ@32066|Fusobacteria	32066|Fusobacteria	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_5643245_2	1232436.CAPF01000053_gene118	2.268e-132	427.0	COG1028@1|root,COG1028@2|Bacteria,2GJU1@201174|Actinobacteria,4CVP2@84998|Coriobacteriia	84998|Coriobacteriia	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD1_k127_5643245_1	397287.C807_00817	5.235e-178	562.0	COG0452@1|root,COG0452@2|Bacteria,1TPP3@1239|Firmicutes,247J3@186801|Clostridia,27J5G@186928|unclassified Lachnospiraceae	186801|Clostridia	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K01598,ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD1_k127_5648962_0	1321778.HMPREF1982_02792	9.846e-262	826.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,247QW@186801|Clostridia,26CG4@186813|unclassified Clostridiales	186801|Clostridia	V	FtsX-like permease family	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX
HKD1_k127_5657265_0	1128398.Curi_c17140	9.992e-115	378.0	COG0240@1|root,COG0240@2|Bacteria,1TQ5P@1239|Firmicutes,248JT@186801|Clostridia,267VM@186813|unclassified Clostridiales	186801|Clostridia	C	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD1_k127_5657265_1	1211817.CCAT010000086_gene2384	9.378e-30	120.0	COG0699@1|root,COG0699@2|Bacteria,1TPPG@1239|Firmicutes,24829@186801|Clostridia,36DMZ@31979|Clostridiaceae	186801|Clostridia	S	ATPase. Has a role at an early stage in the morphogenesis of the spore coat	spoIVA	GO:0000003,GO:0000166,GO:0003674,GO:0003824,GO:0005488,GO:0005524,GO:0005575,GO:0005618,GO:0005623,GO:0008144,GO:0008150,GO:0009653,GO:0009987,GO:0016462,GO:0016787,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0019954,GO:0030154,GO:0030312,GO:0030435,GO:0030436,GO:0030554,GO:0031160,GO:0032502,GO:0032553,GO:0032555,GO:0032559,GO:0034301,GO:0035639,GO:0036094,GO:0042601,GO:0042763,GO:0043167,GO:0043168,GO:0043934,GO:0043936,GO:0044464,GO:0048646,GO:0048856,GO:0048869,GO:0071944,GO:0097159,GO:0097367,GO:1901265,GO:1901363	-	ko:K06398	-	-	-	-	ko00000	-	-	-	Spore_IV_A
HKD1_k127_5658192_1	1151292.QEW_1496	1.477e-95	321.0	COG0778@1|root,COG0778@2|Bacteria,1V297@1239|Firmicutes,24D8F@186801|Clostridia,25SFI@186804|Peptostreptococcaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD1_k127_5658192_0	931276.Cspa_c46710	1.097e-96	321.0	COG1307@1|root,COG1307@2|Bacteria,1TSKD@1239|Firmicutes,24AE9@186801|Clostridia,36F3I@31979|Clostridiaceae	186801|Clostridia	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_5665574_1	926561.KB900617_gene1719	1.033e-29	123.0	COG0514@1|root,COG0608@1|root,COG0514@2|Bacteria,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,247NU@186801|Clostridia,3WB7F@53433|Halanaerobiales	186801|Clostridia	L	TIGRFAM single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,Helicase_C
HKD1_k127_5665574_2	908337.HMPREF9257_1002	3.237e-05	53.0	COG5416@1|root,COG5416@2|Bacteria,1VHTF@1239|Firmicutes,4I628@91061|Bacilli,27E6P@186827|Aerococcaceae	91061|Bacilli	S	Pfam:DUF1049	-	-	-	-	-	-	-	-	-	-	-	-	LapA_dom
HKD1_k127_5665574_0	1031288.AXAA01000005_gene2052	1.144e-50	181.0	COG0641@1|root,COG0641@2|Bacteria,1TQPS@1239|Firmicutes,248DD@186801|Clostridia,36DZR@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM	scfB	-	-	ko:K06871	-	-	-	-	ko00000	-	-	-	Fer4_12,Radical_SAM,SPASM
HKD1_k127_5684884_1	1123009.AUID01000004_gene1512	5.26e-51	184.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,26AYC@186813|unclassified Clostridiales	186801|Clostridia	C	Pyruvate ferredoxin/flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_5684884_0	767817.Desgi_3981	5.224e-131	421.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,263XE@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM UbiD family decarboxylases	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_5705214_1	406124.ACPC01000050_gene378	7.016e-50	188.0	2DBTR@1|root,2ZB0I@2|Bacteria,1V1SY@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5705214_0	1123288.SOV_2c05030	1.611e-65	239.0	28IPT@1|root,2Z8PM@2|Bacteria,1UCI1@1239|Firmicutes,4H62T@909932|Negativicutes	909932|Negativicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_573446_2	350688.Clos_2006	1.544e-07	53.0	COG2227@1|root,COG2227@2|Bacteria,1V218@1239|Firmicutes,25EUC@186801|Clostridia,36UUN@31979|Clostridiaceae	186801|Clostridia	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_573446_1	1347392.CCEZ01000074_gene1896	9.757e-29	121.0	COG0500@1|root,COG2226@2|Bacteria,1TQUF@1239|Firmicutes,25E3F@186801|Clostridia,36UHC@31979|Clostridiaceae	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_573446_0	1304284.L21TH_1016	5.188e-70	242.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,36DPJ@31979|Clostridiaceae	186801|Clostridia	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD1_k127_5758073_0	632245.CLP_3230	9.397e-145	468.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	-	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_5758073_1	445971.ANASTE_00983	1.131e-31	126.0	COG0569@1|root,COG0569@2|Bacteria,1TQ9H@1239|Firmicutes,249C2@186801|Clostridia,25VKV@186806|Eubacteriaceae	186801|Clostridia	P	TrkA N-terminal domain protein	ktrA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_5764051_1	655811.HMPREF0078_1330	9.381e-130	422.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia,22GCK@1570339|Peptoniphilaceae	186801|Clostridia	F	permease	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
HKD1_k127_5764051_0	997350.HMPREF9129_1030	2.221e-232	724.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,22G3R@1570339|Peptoniphilaceae	186801|Clostridia	F	selenium metabolism protein SsnA	ssnA	-	3.5.4.40	ko:K20810	ko00130,ko01110,map00130,map01110	-	R10695	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_5764051_2	1007096.BAGW01000021_gene370	1.847e-112	368.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,2N6XI@216572|Oscillospiraceae	186801|Clostridia	E	Amino acid kinase family	arcC	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_5766584_0	1121289.JHVL01000009_gene1488	2.768e-193	607.0	COG0519@1|root,COG0519@2|Bacteria,1TPG8@1239|Firmicutes,2487F@186801|Clostridia,36EFK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase,tRNA_Me_trans
HKD1_k127_5770130_1	1304866.K413DRAFT_1096	2.678e-05	49.0	COG0840@1|root,COG0840@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia,36DH1@31979|Clostridiaceae	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	4HB_MCP_1,HAMP,MCPsignal,dCache_1
HKD1_k127_5770130_0	1151292.QEW_1883	3.712e-93	313.0	COG0834@1|root,COG2199@1|root,COG2200@1|root,COG0834@2|Bacteria,COG2199@2|Bacteria,COG2200@2|Bacteria,1TS8B@1239|Firmicutes,24EZ4@186801|Clostridia	186801|Clostridia	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,SBP_bac_3,dCache_1
HKD1_k127_5772506_0	1301100.HG529431_gene1762	1.269e-162	529.0	COG1067@1|root,COG1067@2|Bacteria,1TQT5@1239|Firmicutes,248NE@186801|Clostridia,36E00@31979|Clostridiaceae	186801|Clostridia	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD1_k127_5772506_1	558169.AGAV01000005_gene2273	1.131e-08	56.0	COG4443@1|root,COG4443@2|Bacteria,1VEFE@1239|Firmicutes,4HNSP@91061|Bacilli	91061|Bacilli	S	protein conserved in bacteria	XK26_06125	-	-	-	-	-	-	-	-	-	-	-	PC4
HKD1_k127_5773450_0	445973.CLOBAR_02850	8.206e-13	70.0	2BX75@1|root,32YCI@2|Bacteria,1VEDY@1239|Firmicutes,259IZ@186801|Clostridia,25RTF@186804|Peptostreptococcaceae	186801|Clostridia	S	Small, acid-soluble spore proteins, alpha/beta type	-	-	-	-	-	-	-	-	-	-	-	-	SASP
HKD1_k127_5773867_0	553973.CLOHYLEM_06355	1.367e-142	456.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia,21XZX@1506553|Lachnoclostridium	186801|Clostridia	F	Formyltetrahydrofolate synthetase	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD1_k127_5773867_1	1105031.HMPREF1141_2732	2.844e-63	224.0	COG0457@1|root,COG3629@1|root,COG3899@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG3899@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia,36DWM@31979|Clostridiaceae	186801|Clostridia	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
HKD1_k127_5781252_2	411463.EUBVEN_01154	1.568e-08	56.0	COG0765@1|root,COG0765@2|Bacteria,1TPM3@1239|Firmicutes,248UY@186801|Clostridia,25W65@186806|Eubacteriaceae	186801|Clostridia	P	ABC transporter, permease protein	-	-	-	ko:K02029,ko:K17073,ko:K17074	ko02010,map02010	M00236,M00589	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.3,3.A.1.3.20	-	-	BPD_transp_1,SBP_bac_3
HKD1_k127_5781252_1	926561.KB900619_gene2402	2.36e-29	120.0	COG1388@1|root,COG1388@2|Bacteria	2|Bacteria	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
HKD1_k127_5781252_0	1410653.JHVC01000007_gene626	3.669e-46	167.0	COG0393@1|root,COG0393@2|Bacteria,1VADM@1239|Firmicutes,24NFX@186801|Clostridia,36K0Z@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the UPF0145 family	-	-	-	-	-	-	-	-	-	-	-	-	YbjQ_1
HKD1_k127_5786231_1	1347392.CCEZ01000075_gene3004	1.371e-33	132.0	COG1193@1|root,COG1193@2|Bacteria,1TSBW@1239|Firmicutes,24814@186801|Clostridia,36FV5@31979|Clostridiaceae	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
HKD1_k127_5786231_0	1347392.CCEZ01000075_gene3005	5.464e-158	501.0	COG0274@1|root,COG0274@2|Bacteria,1TPA0@1239|Firmicutes,249YN@186801|Clostridia,36F7D@31979|Clostridiaceae	186801|Clostridia	F	D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit	kamD	-	5.4.3.3	ko:K01844	ko00310,map00310	-	R02852,R03275	RC00719	ko00000,ko00001,ko01000	-	-	-	Lys-AminoMut_A
HKD1_k127_5789500_0	720554.Clocl_0756	1.438e-257	801.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	por2	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_5789500_1	720554.Clocl_0757	4.558e-19	89.0	2EHNY@1|root,33BER@2|Bacteria,1VKJW@1239|Firmicutes,24USU@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF3787)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3787
HKD1_k127_5795492_0	1120746.CCNL01000004_gene58	1.936e-64	223.0	COG1274@1|root,COG1274@2|Bacteria,2NQRD@2323|unclassified Bacteria	2|Bacteria	C	Phosphoenolpyruvate carboxykinase C-terminal P-loop domain	pckG	-	4.1.1.32,4.1.1.49	ko:K01596,ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko03320,ko04068,ko04151,ko04152,ko04910,ko04920,ko04922,ko04931,ko04964,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200,map03320,map04068,map04151,map04152,map04910,map04920,map04922,map04931,map04964	M00003,M00170	R00341,R00431,R00726	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP,PEPCK_C,PEPCK_N
HKD1_k127_5795492_1	1121342.AUCO01000015_gene2687	3.881e-62	219.0	COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,36DHY@31979|Clostridiaceae	186801|Clostridia	J	elongation factor G	tetP	-	-	-	-	-	-	-	-	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP
HKD1_k127_5798154_2	1410631.JHWZ01000001_gene946	4.392e-13	73.0	COG4632@1|root,COG4632@2|Bacteria,1TP2R@1239|Firmicutes,249PA@186801|Clostridia,27K92@186928|unclassified Lachnospiraceae	186801|Clostridia	G	Phosphodiester glycosidase	-	-	-	-	-	-	-	-	-	-	-	-	NAGPA
HKD1_k127_5798154_0	398512.JQKC01000001_gene2310	9.9e-142	455.0	COG1533@1|root,COG1533@2|Bacteria,1TSS2@1239|Firmicutes,248SB@186801|Clostridia,3WH7N@541000|Ruminococcaceae	186801|Clostridia	L	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_5798154_1	886882.PPSC2_p0116	1.91e-113	377.0	COG0608@1|root,COG0608@2|Bacteria,1TPXE@1239|Firmicutes,4H9UP@91061|Bacilli,26QNN@186822|Paenibacillaceae	91061|Bacilli	L	Single-stranded-DNA-specific exonuclease recj	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1,ssDNA-exonuc_C
HKD1_k127_5822526_1	1230342.CTM_10526	2.082e-30	121.0	COG5460@1|root,COG5460@2|Bacteria,1VG76@1239|Firmicutes,24R3G@186801|Clostridia,36M5J@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized conserved protein (DUF2164)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2164
HKD1_k127_5822526_0	1230342.CTM_15997	1.155e-71	252.0	COG0697@1|root,COG0697@2|Bacteria,1TPUW@1239|Firmicutes,247X1@186801|Clostridia,36FB9@31979|Clostridiaceae	186801|Clostridia	EG	DMT(Drug metabolite transporter) superfamily permease	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD1_k127_5822526_2	1347392.CCEZ01000049_gene1389	5.561e-16	78.0	COG1803@1|root,COG1803@2|Bacteria,1V3KQ@1239|Firmicutes,24FUQ@186801|Clostridia,36IPD@31979|Clostridiaceae	186801|Clostridia	G	methylglyoxal synthase	mgsA	-	2.7.1.24,4.2.3.3	ko:K00859,ko:K01734	ko00640,ko00770,ko01100,ko01120,map00640,map00770,map01100,map01120	M00120	R00130,R01016	RC00002,RC00078,RC00424	ko00000,ko00001,ko00002,ko01000	-	-	-	MGS
HKD1_k127_5826380_1	994573.T472_0202845	4.032e-68	233.0	COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,36DN5@31979|Clostridiaceae	186801|Clostridia	F	Permease	uraA	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
HKD1_k127_5826380_0	720554.Clocl_0756	5.948e-222	693.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	por2	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_5826969_2	1151292.QEW_1783	9.526e-81	273.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,25T23@186804|Peptostreptococcaceae	186801|Clostridia	E	Peptidase dimerisation domain	cpsA	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5826969_3	332101.JIBU02000052_gene3544	4.073e-40	151.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	cpsA	-	-	ko:K01436	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_5826969_0	411902.CLOBOL_06421	3.157e-137	446.0	COG0787@1|root,COG0787@2|Bacteria,1TNYY@1239|Firmicutes,2480T@186801|Clostridia,222IN@1506553|Lachnoclostridium	186801|Clostridia	M	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD1_k127_5826969_1	1120998.AUFC01000017_gene161	3.244e-99	333.0	COG1619@1|root,COG1619@2|Bacteria,1TRBB@1239|Firmicutes,24ABA@186801|Clostridia,3WD9H@538999|Clostridiales incertae sedis	186801|Clostridia	V	LD-carboxypeptidase	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HKD1_k127_5833000_0	1120998.AUFC01000003_gene1366	1.225e-154	500.0	COG0643@1|root,COG0643@2|Bacteria,1TPMS@1239|Firmicutes,24858@186801|Clostridia,3WCTV@538999|Clostridiales incertae sedis	186801|Clostridia	NT	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt,P2
HKD1_k127_5833000_1	1120746.CCNL01000011_gene1508	1.158e-23	102.0	COG1352@1|root,COG1352@2|Bacteria,2NQTA@2323|unclassified Bacteria	2|Bacteria	NT	Methyltransferase, chemotaxis proteins	cheR	GO:0003674,GO:0003824,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0005886,GO:0006464,GO:0006479,GO:0006807,GO:0006935,GO:0008022,GO:0008150,GO:0008152,GO:0008168,GO:0008171,GO:0008213,GO:0008276,GO:0008757,GO:0008983,GO:0009605,GO:0009987,GO:0010340,GO:0016020,GO:0016740,GO:0016741,GO:0019538,GO:0032259,GO:0032991,GO:0036211,GO:0040011,GO:0042221,GO:0042330,GO:0043170,GO:0043412,GO:0043414,GO:0044237,GO:0044238,GO:0044260,GO:0044267,GO:0044424,GO:0044444,GO:0044464,GO:0050896,GO:0051998,GO:0071704,GO:0071944,GO:0098561,GO:0140096,GO:1901564	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR,CheR_N
HKD1_k127_5842870_0	742723.HMPREF9477_01234	3.933e-116	378.0	COG0502@1|root,COG0502@2|Bacteria,1TPYQ@1239|Firmicutes,248H8@186801|Clostridia,27JVR@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Elongator protein 3, MiaB family, Radical SAM	hydE	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	Radical_SAM
HKD1_k127_5842870_3	903814.ELI_3375	1.53e-33	131.0	COG0864@1|root,COG0864@2|Bacteria,1VF9M@1239|Firmicutes,24QVJ@186801|Clostridia,25XEG@186806|Eubacteriaceae	186801|Clostridia	K	iron-only hydrogenase system regulator	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5842870_1	1009370.ALO_05123	3.273e-85	287.0	COG0663@1|root,COG0663@2|Bacteria,1V6CZ@1239|Firmicutes,4H48R@909932|Negativicutes	909932|Negativicutes	S	Bacterial transferase hexapeptide repeat protein	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD1_k127_5842870_2	871963.Desdi_0749	2.421e-49	180.0	COG1647@1|root,COG1647@2|Bacteria,1TQ7X@1239|Firmicutes,24HZH@186801|Clostridia,2629Z@186807|Peptococcaceae	186801|Clostridia	S	Alpha/beta hydrolase family	-	-	3.1.1.1	ko:K03928	-	-	-	-	ko00000,ko01000	-	-	-	Hydrolase_4
HKD1_k127_5847715_0	702450.CUW_2431	2.176e-117	395.0	COG0553@1|root,COG0553@2|Bacteria,1TPFZ@1239|Firmicutes,3VPRH@526524|Erysipelotrichia	526524|Erysipelotrichia	L	SNF2 family N-terminal domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Helicase_C,SNF2_N,SNF2_assoc,SWIM
HKD1_k127_5850510_4	536232.CLM_0399	7.308e-25	107.0	COG4512@1|root,COG4512@2|Bacteria,1VF1N@1239|Firmicutes,24SCM@186801|Clostridia,36HYN@31979|Clostridiaceae	186801|Clostridia	KOT	PFAM Accessory gene regulator B	-	-	-	ko:K07813	ko02020,ko02024,map02020,map02024	-	-	-	ko00000,ko00001,ko01002	-	-	-	AgrB
HKD1_k127_5850510_6	293826.Amet_1280	8.422e-18	89.0	2DS4E@1|root,33EGF@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5850510_5	1297617.JPJD01000002_gene2692	4.586e-22	100.0	2E5GB@1|root,33080@2|Bacteria,1VF18@1239|Firmicutes,24R5R@186801|Clostridia,269KJ@186813|unclassified Clostridiales	186801|Clostridia	S	Psort location	-	-	-	-	-	-	-	-	-	-	-	-	CorC_HlyC
HKD1_k127_5850510_0	632245.CLP_2309	1.9e-128	411.0	COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,2497A@186801|Clostridia,36DMD@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD1_k127_5850510_2	1345695.CLSA_c15610	3.345e-101	332.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,36DD1@31979|Clostridiaceae	186801|Clostridia	F	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_5850510_1	1345695.CLSA_c15600	2.4e-112	365.0	COG0602@1|root,COG0602@2|Bacteria,1TQ58@1239|Firmicutes,2499R@186801|Clostridia,36HKB@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_12,Fer4_14,Radical_SAM
HKD1_k127_5850510_3	1345695.CLSA_c15590	3.344e-68	233.0	COG0720@1|root,COG0720@2|Bacteria,1VAJX@1239|Firmicutes,24JS9@186801|Clostridia,36JJD@31979|Clostridiaceae	186801|Clostridia	H	synthase	queD	-	4.1.2.50,4.2.3.12	ko:K01737	ko00790,ko01100,map00790,map01100	M00842,M00843	R04286,R09959	RC01117,RC02846,RC02847	ko00000,ko00001,ko00002,ko01000,ko03016	-	-	-	PTPS
HKD1_k127_5851433_6	935845.JADQ01000014_gene3425	0.0001697	46.0	2E62M@1|root,32ZH6@2|Bacteria,1VF10@1239|Firmicutes,4HP0J@91061|Bacilli,26ZTN@186822|Paenibacillaceae	91061|Bacilli	S	spore protein	tlp	-	-	ko:K06434	-	-	-	-	ko00000	-	-	-	-
HKD1_k127_5851433_0	994573.T472_0200175	0.0	1027.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_5851433_4	994573.T472_0200170	2.834e-59	207.0	COG1142@1|root,COG1142@2|Bacteria,1V6Y9@1239|Firmicutes,24HFG@186801|Clostridia,36IU3@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S dicluster domain	-	-	-	ko:K05796	-	-	-	-	ko00000	-	-	-	Fer4_4,Fer4_6
HKD1_k127_5851433_2	931626.Awo_c34410	5.872e-93	312.0	COG0789@1|root,COG0789@2|Bacteria,1V05W@1239|Firmicutes,24EVM@186801|Clostridia	186801|Clostridia	K	transcriptional regulator, MerR family	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD1_k127_5851433_1	1449050.JNLE01000005_gene5162	1.315e-166	531.0	COG1744@1|root,COG1744@2|Bacteria,1TPEU@1239|Firmicutes,248QT@186801|Clostridia,36EW8@31979|Clostridiaceae	186801|Clostridia	S	basic membrane	tmpC	-	-	ko:K07335	-	-	-	-	ko00000	-	-	-	Bmp
HKD1_k127_5851433_3	1449050.JNLE01000005_gene5161	2.97e-90	298.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	yufO	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_5852715_0	411902.CLOBOL_04038	3.153e-231	722.0	COG1288@1|root,COG1288@2|Bacteria,1TQJ0@1239|Firmicutes,248UK@186801|Clostridia,222HP@1506553|Lachnoclostridium	186801|Clostridia	S	C4-dicarboxylate anaerobic carrier	-	-	-	-	-	-	-	-	-	-	-	-	DcuC
HKD1_k127_5853798_0	411462.DORLON_00252	7.006e-96	318.0	COG1951@1|root,COG1951@2|Bacteria,1TPXQ@1239|Firmicutes,248T7@186801|Clostridia,27W46@189330|Dorea	186801|Clostridia	C	COG COG1951 Tartrate dehydratase alpha subunit Fumarate hydratase class I, N-terminal domain	-	-	4.2.1.32	ko:K03779	ko00630,map00630	-	R00339	RC01382	ko00000,ko00001,ko01000	-	-	-	Fumerase
HKD1_k127_5853798_2	1265490.JHVY01000031_gene2598	2.345e-30	120.0	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,1RPUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Tartrate	ttdA	GO:0008150,GO:0008152,GO:1901275	4.2.1.32	ko:K03779	ko00630,map00630	-	R00339	RC01382	ko00000,ko00001,ko01000	-	-	iLF82_1304.LF82_2330	Fumerase
HKD1_k127_5853798_1	220341.16504416	7.668e-56	196.0	COG1838@1|root,COG1838@2|Bacteria,1MVNG@1224|Proteobacteria,1RMT4@1236|Gammaproteobacteria,3ZJXP@590|Salmonella	1236|Gammaproteobacteria	C	Fumarase C-terminus	ttdB	GO:0006950,GO:0008150,GO:0009266,GO:0009408,GO:0009628,GO:0050896	4.2.1.32	ko:K03780	ko00630,map00630	-	R00339	RC01382	ko00000,ko00001,ko01000	-	-	iSBO_1134.SBO_2920	Fumerase_C
HKD1_k127_5856473_4	1120998.AUFC01000003_gene1382	9.4e-14	74.0	COG1684@1|root,COG1684@2|Bacteria,1TRB2@1239|Firmicutes,24ECW@186801|Clostridia,3WDN2@538999|Clostridiales incertae sedis	186801|Clostridia	N	Bacterial export proteins, family 1	fliR	-	-	ko:K02421	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_1
HKD1_k127_5856473_3	1120746.CCNL01000011_gene1487	6.143e-23	100.0	COG1987@1|root,COG1987@2|Bacteria,2NQ8H@2323|unclassified Bacteria	2|Bacteria	N	Bacterial export proteins, family 3	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
HKD1_k127_5856473_1	1120998.AUFC01000003_gene1384	1.25e-83	284.0	COG1338@1|root,COG1338@2|Bacteria,1TPIE@1239|Firmicutes,2487C@186801|Clostridia,3WD26@538999|Clostridiales incertae sedis	186801|Clostridia	N	Plays a role in the flagellum-specific transport system	fliP	-	-	ko:K02419	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliP
HKD1_k127_5856473_5	1410625.JHWK01000003_gene1817	2.576e-06	55.0	2DQ6V@1|root,3350C@2|Bacteria,1VH6I@1239|Firmicutes,24R6T@186801|Clostridia,27PFX@186928|unclassified Lachnospiraceae	186801|Clostridia	S	Flagellar biosynthesis protein, FliO	-	-	-	ko:K02418	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliO
HKD1_k127_5856473_2	1304866.K413DRAFT_0043	6.179e-50	180.0	COG2204@1|root,COG2204@2|Bacteria,1UHXE@1239|Firmicutes,25E6A@186801|Clostridia,36UNF@31979|Clostridiaceae	186801|Clostridia	T	cheY-homologous receiver domain	cheY	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD1_k127_5856473_0	1120998.AUFC01000003_gene1387	2.169e-94	322.0	COG1776@1|root,COG1886@1|root,COG1776@2|Bacteria,COG1886@2|Bacteria,1TPT8@1239|Firmicutes,24821@186801|Clostridia,3WDI1@538999|Clostridiales incertae sedis	186801|Clostridia	N	PFAM surface presentation of antigens (SPOA)	fliN	-	-	ko:K02417	ko02030,ko02040,map02030,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2,3.A.6.3	-	-	CheC,FliMN_C
HKD1_k127_5856504_0	1304284.L21TH_1042	2.632e-247	775.0	COG0018@1|root,COG0018@2|Bacteria,1TPEZ@1239|Firmicutes,248JZ@186801|Clostridia,36DCT@31979|Clostridiaceae	186801|Clostridia	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1d
HKD1_k127_5856610_0	1226325.HMPREF1548_06996	5.046e-48	177.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_5856610_1	1297617.JPJD01000035_gene641	1.933e-16	83.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,2692H@186813|unclassified Clostridiales	186801|Clostridia	E	ABC transporter, substrate-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_5856966_0	1408823.AXUS01000008_gene2267	2.15e-89	300.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,25QVG@186804|Peptostreptococcaceae	186801|Clostridia	CO	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
HKD1_k127_5856966_1	1262914.BN533_01796	2.699e-54	194.0	COG1733@1|root,COG1733@2|Bacteria,1V622@1239|Firmicutes	1239|Firmicutes	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_5856966_2	428125.CLOLEP_02942	6.565e-14	72.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WNV1@541000|Ruminococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_5884746_0	641107.CDLVIII_5133	3.306e-202	636.0	COG0477@1|root,COG0477@2|Bacteria,1TPHW@1239|Firmicutes,2492B@186801|Clostridia,36DJR@31979|Clostridiaceae	186801|Clostridia	EGP	PFAM Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_5884746_1	1226325.HMPREF1548_00101	1.121e-125	416.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia,36EDE@31979|Clostridiaceae	186801|Clostridia	V	MatE	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_5892368_1	1382315.JPOI01000001_gene148	1.712e-08	61.0	COG2153@1|root,COG2153@2|Bacteria,1VA2J@1239|Firmicutes,4HKF5@91061|Bacilli,1WGF1@129337|Geobacillus	91061|Bacilli	S	FR47-like protein	yjcF	GO:0003674,GO:0003824,GO:0016740,GO:0016746,GO:0016747	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD1_k127_5892368_0	203119.Cthe_0648	3.479e-297	918.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,3WGJQ@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_5893546_0	1304284.L21TH_0445	0.0	1875.0	COG0085@1|root,COG0085@2|Bacteria,1TP96@1239|Firmicutes,247J1@186801|Clostridia,36EKQ@31979|Clostridiaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD1_k127_5893546_1	1304284.L21TH_0444	0.0	1781.0	COG0086@1|root,COG0086@2|Bacteria,1TNYT@1239|Firmicutes,24925@186801|Clostridia,36EQT@31979|Clostridiaceae	186801|Clostridia	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD1_k127_5893546_7	756499.Desde_0418	1.508e-16	81.0	COG1358@1|root,COG1358@2|Bacteria,1VFD8@1239|Firmicutes,24R27@186801|Clostridia,262TV@186807|Peptococcaceae	186801|Clostridia	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	-	-	-	ko:K07590	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L7Ae
HKD1_k127_5893546_5	1121289.JHVL01000060_gene2530	3.348e-66	228.0	COG0048@1|root,COG0048@2|Bacteria,1V1FJ@1239|Firmicutes,24FQT@186801|Clostridia,36IR5@31979|Clostridiaceae	186801|Clostridia	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD1_k127_5893546_4	1121289.JHVL01000060_gene2529	3e-82	275.0	COG0049@1|root,COG0049@2|Bacteria,1V1GG@1239|Firmicutes,24FQN@186801|Clostridia,36DC5@31979|Clostridiaceae	186801|Clostridia	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD1_k127_5893546_6	887929.HMP0721_1513	2.271e-64	221.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,25VFH@186806|Eubacteriaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_5893546_2	1304284.L21TH_0440	1.661e-286	887.0	COG0480@1|root,COG0480@2|Bacteria,1TPF9@1239|Firmicutes,247VN@186801|Clostridia,36EHS@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_5893546_3	944565.HMPREF9127_1590	3.834e-88	292.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,22GIR@1570339|Peptoniphilaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_5896946_0	1444310.JANV01000136_gene2592	5.189e-175	557.0	COG3633@1|root,COG3633@2|Bacteria,1TPD2@1239|Firmicutes,4HBEC@91061|Bacilli,1ZC2H@1386|Bacillus	91061|Bacilli	E	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)	sstT	-	-	ko:K07862	-	-	-	-	ko00000,ko02000	2.A.23.4	-	-	SDF
HKD1_k127_5896946_1	1347392.CCEZ01000020_gene915	2.553e-169	542.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,36DJD@31979|Clostridiaceae	186801|Clostridia	V	MATE efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_5896946_2	1476973.JMMB01000007_gene2203	1.498e-64	224.0	COG0778@1|root,COG0778@2|Bacteria,1V4DP@1239|Firmicutes,24HBZ@186801|Clostridia,25TFY@186804|Peptostreptococcaceae	186801|Clostridia	C	Putative TM nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD1_k127_5896946_3	536227.CcarbDRAFT_0798	2.852e-46	169.0	COG1280@1|root,COG1280@2|Bacteria,1TSNA@1239|Firmicutes,24CNE@186801|Clostridia,36JRF@31979|Clostridiaceae	186801|Clostridia	E	PFAM Lysine exporter protein (LYSE YGGA)	-	-	-	ko:K11249	-	-	-	-	ko00000,ko02000	2.A.76.1.4	-	-	LysE
HKD1_k127_5897397_1	1294142.CINTURNW_3138	3.751e-51	186.0	COG0703@1|root,COG0703@2|Bacteria,1VA6Z@1239|Firmicutes,24MQY@186801|Clostridia,36JKN@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD1_k127_5897397_0	1121289.JHVL01000001_gene1863	7.985e-63	239.0	COG1352@1|root,COG1352@2|Bacteria,1TSUQ@1239|Firmicutes,24DT0@186801|Clostridia,36IQW@31979|Clostridiaceae	186801|Clostridia	NT	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_5898801_1	610130.Closa_0245	8.505e-15	77.0	29XCN@1|root,30J2H@2|Bacteria,1UVJS@1239|Firmicutes,25937@186801|Clostridia,221FV@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5898801_0	357809.Cphy_1922	5.792e-111	366.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,21Y52@1506553|Lachnoclostridium	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_5902257_0	1121289.JHVL01000002_gene2358	1.199e-100	341.0	COG0635@1|root,COG0635@2|Bacteria,1TPES@1239|Firmicutes,247P8@186801|Clostridia,36DU5@31979|Clostridiaceae	186801|Clostridia	H	Involved in the biosynthesis of porphyrin-containing compound	hemN	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD1_k127_5902257_1	1304284.L21TH_1370	1.033e-14	74.0	COG1420@1|root,COG1420@2|Bacteria,1TQP7@1239|Firmicutes,247K2@186801|Clostridia,36DW8@31979|Clostridiaceae	186801|Clostridia	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD1_k127_5904119_2	994573.T472_0204225	2.148e-104	349.0	COG0523@1|root,COG0523@2|Bacteria,1TPCG@1239|Firmicutes,248ZX@186801|Clostridia,36I40@31979|Clostridiaceae	186801|Clostridia	S	Cobalamin synthesis protein cobW C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	CobW_C,cobW
HKD1_k127_5904119_1	994573.T472_0204215	6.496e-271	837.0	COG2768@1|root,COG2768@2|Bacteria,1TQAW@1239|Firmicutes,247IS@186801|Clostridia,36EQY@31979|Clostridiaceae	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K07138	-	-	-	-	ko00000	-	-	-	DUF362,Fer4,Fer4_21
HKD1_k127_5904119_0	994573.T472_0204210	3.814e-292	908.0	COG2414@1|root,COG2414@2|Bacteria,1TPT9@1239|Firmicutes,2481Q@186801|Clostridia,36FZW@31979|Clostridiaceae	186801|Clostridia	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_5917151_0	1347392.CCEZ01000043_gene126	2.001e-88	298.0	COG0183@1|root,COG0183@2|Bacteria,1UHVW@1239|Firmicutes,248BM@186801|Clostridia,36DQK@31979|Clostridiaceae	186801|Clostridia	I	Stage V sporulation protein AD	spoVAD	-	-	ko:K06406	-	-	-	-	ko00000	-	-	-	SpoVAD
HKD1_k127_5917151_1	1301100.HG529405_gene297	1.36e-42	160.0	2ANER@1|root,31DDD@2|Bacteria,1V46U@1239|Firmicutes,24JDI@186801|Clostridia,36IPY@31979|Clostridiaceae	186801|Clostridia	S	stage V sporulation protein AC	spoVAC	-	-	ko:K06405	-	-	-	-	ko00000	-	-	-	SpoVAC_SpoVAEB
HKD1_k127_5920371_2	1123405.AUMM01000048_gene3092	1.421e-05	58.0	COG1277@1|root,COG1277@2|Bacteria,1TRJ8@1239|Firmicutes,4HA9I@91061|Bacilli,26PPG@186821|Sporolactobacillaceae	91061|Bacilli	S	ABC-type transport system involved in multi-copper enzyme maturation permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	-
HKD1_k127_5920371_0	457570.Nther_0731	1.495e-73	258.0	COG1131@1|root,COG1131@2|Bacteria,1TPQW@1239|Firmicutes,248F7@186801|Clostridia	186801|Clostridia	V	Abc transporter	ytrB	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_5920371_1	997296.PB1_11674	1.829e-22	101.0	COG1725@1|root,COG1725@2|Bacteria,1VFD0@1239|Firmicutes,4HNIT@91061|Bacilli,1ZQA5@1386|Bacillus	91061|Bacilli	K	Transcriptional regulator	ytrA	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD1_k127_5923992_1	1121342.AUCO01000017_gene2860	4.353e-49	179.0	COG1234@1|root,COG1234@2|Bacteria,1TRGP@1239|Firmicutes,248EQ@186801|Clostridia,36E2R@31979|Clostridiaceae	186801|Clostridia	S	Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA	rnz	-	3.1.26.11	ko:K00784	ko03013,map03013	-	-	-	ko00000,ko00001,ko01000,ko03016	-	-	-	Lactamase_B_2
HKD1_k127_5923992_2	1280692.AUJL01000004_gene849	4.797e-24	105.0	2EF94@1|root,33920@2|Bacteria,1VIXN@1239|Firmicutes,24U6R@186801|Clostridia,36N3P@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_5923992_0	1511.CLOST_0902	4.271e-101	340.0	COG4124@1|root,COG4124@2|Bacteria,1U8S3@1239|Firmicutes,24C93@186801|Clostridia	186801|Clostridia	G	Glycosyl hydrolase family 26	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_26
HKD1_k127_5946191_2	1262914.BN533_01796	5.885e-46	168.0	COG1733@1|root,COG1733@2|Bacteria,1V622@1239|Firmicutes	1239|Firmicutes	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_5946191_0	428125.CLOLEP_02942	1.238e-95	320.0	COG0492@1|root,COG0492@2|Bacteria,1TNZS@1239|Firmicutes,2491M@186801|Clostridia,3WNV1@541000|Ruminococcaceae	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD1_k127_5946191_3	428125.CLOLEP_02943	1.31e-35	138.0	COG3118@1|root,COG3118@2|Bacteria,1VA3Y@1239|Firmicutes,24MM5@186801|Clostridia,3WJVA@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD1_k127_5946191_1	1540257.JQMW01000011_gene1511	5.466e-50	182.0	COG1670@1|root,COG1670@2|Bacteria,1V1G8@1239|Firmicutes,24G73@186801|Clostridia,36HY5@31979|Clostridiaceae	186801|Clostridia	J	GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD1_k127_5950915_2	857293.CAAU_2571	6.919e-72	246.0	COG0849@1|root,COG0849@2|Bacteria,1TQC5@1239|Firmicutes,24BFJ@186801|Clostridia,36ER4@31979|Clostridiaceae	186801|Clostridia	D	MutL protein	-	-	-	-	-	-	-	-	-	-	-	-	MutL
HKD1_k127_5950915_0	1123009.AUID01000004_gene1529	4.144e-136	441.0	COG3457@1|root,COG3457@2|Bacteria,1TNYJ@1239|Firmicutes,248MC@186801|Clostridia,267XN@186813|unclassified Clostridiales	186801|Clostridia	E	Alanine racemase, N-terminal domain	orr	GO:0003674,GO:0003824,GO:0005488,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008144,GO:0008150,GO:0008152,GO:0009987,GO:0016853,GO:0016854,GO:0016855,GO:0019752,GO:0019842,GO:0036094,GO:0036361,GO:0043167,GO:0043169,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047661,GO:0048037,GO:0050157,GO:0070279,GO:0070280,GO:0071704,GO:0097159,GO:1901363,GO:1901564,GO:1901605	5.1.1.12	ko:K21898	ko00472,map00472	-	R00672	RC00302	ko00000,ko00001,ko01000	-	-	-	Ala_racemase_N
HKD1_k127_5950915_1	1286171.EAL2_808p07060	2.659e-131	435.0	COG1705@1|root,COG1705@2|Bacteria,1V7JY@1239|Firmicutes,24C0T@186801|Clostridia,25ZAN@186806|Eubacteriaceae	186801|Clostridia	NU	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase	-	-	-	ko:K02395	-	-	-	-	ko00000,ko02035	-	-	-	Cu_amine_oxidN1,Glucosaminidase,PG_binding_1
HKD1_k127_5952992_2	742741.HMPREF9475_00038	2.415e-18	86.0	COG3404@1|root,COG3404@2|Bacteria,1VVEM@1239|Firmicutes,24JAH@186801|Clostridia	186801|Clostridia	E	Formiminotransferase-cyclodeaminase	-	-	-	-	-	-	-	-	-	-	-	-	FTCD_C
HKD1_k127_5952992_1	742741.HMPREF9475_00037	8.65e-142	454.0	COG3643@1|root,COG3643@2|Bacteria,1UYYH@1239|Firmicutes,24FG1@186801|Clostridia	186801|Clostridia	E	Formiminotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	FTCD,FTCD_N
HKD1_k127_5952992_0	742741.HMPREF9475_00033	1.366e-142	458.0	COG2986@1|root,COG2986@2|Bacteria,1TPCW@1239|Firmicutes,247XP@186801|Clostridia	186801|Clostridia	E	Histidine ammonia-lyase	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD1_k127_5955176_0	1347392.CCEZ01000043_gene24	4.652e-110	359.0	COG0554@1|root,COG0554@2|Bacteria,1TPX3@1239|Firmicutes,2493W@186801|Clostridia,36EMF@31979|Clostridiaceae	186801|Clostridia	F	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD1_k127_5955176_1	1033810.HLPCO_000595	2.162e-67	239.0	COG0006@1|root,COG0006@2|Bacteria,2NP8P@2323|unclassified Bacteria	2|Bacteria	E	Metallopeptidase family M24	pepP	GO:0003674,GO:0003824,GO:0004177,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008235,GO:0008237,GO:0008238,GO:0016787,GO:0019538,GO:0030145,GO:0042802,GO:0043167,GO:0043169,GO:0043170,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046872,GO:0046914,GO:0070011,GO:0071704,GO:0140096,GO:1901564	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	AMP_N,Peptidase_M24
HKD1_k127_5982472_0	386415.NT01CX_0391	6.964e-132	426.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,36E5B@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_6043102_1	592031.GCWU000322_00996	1.163e-12	69.0	COG1032@1|root,COG1032@2|Bacteria,1TQF0@1239|Firmicutes,24A0T@186801|Clostridia,25URD@186806|Eubacteriaceae	186801|Clostridia	C	Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_6043102_0	350688.Clos_0634	2.561e-52	188.0	COG1765@1|root,COG1765@2|Bacteria,1V7SN@1239|Firmicutes,24SS3@186801|Clostridia,36K9Q@31979|Clostridiaceae	186801|Clostridia	O	OsmC-like protein	-	-	-	ko:K07397	-	-	-	-	ko00000	-	-	-	OsmC
HKD1_k127_6050618_1	1128398.Curi_c27590	1.651e-40	151.0	COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24KBG@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	hxlR	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_6050618_0	1195236.CTER_3528	1.621e-173	553.0	COG2221@1|root,COG4624@1|root,COG2221@2|Bacteria,COG4624@2|Bacteria,1TQIR@1239|Firmicutes,248BS@186801|Clostridia,3WHZ4@541000|Ruminococcaceae	186801|Clostridia	C	Iron only hydrogenase large subunit, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Fe_hyd_lg_C,Fer4
HKD1_k127_6050618_2	509191.AEDB02000098_gene3523	3.518e-37	147.0	arCOG08054@1|root,2Z8AD@2|Bacteria,1TQ1J@1239|Firmicutes,2485U@186801|Clostridia,3WH6F@541000|Ruminococcaceae	186801|Clostridia	S	Carbohydrate-binding domain-containing protein Cthe_2159	-	GO:0001871,GO:0003674,GO:0005488,GO:0005509,GO:0030246,GO:0030247,GO:0030248,GO:0043167,GO:0043169,GO:0046872,GO:0048028,GO:2001062	-	-	-	-	-	-	-	-	-	-	Cthe_2159
HKD1_k127_6065566_1	865861.AZSU01000007_gene1078	5.952e-56	197.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,36W8D@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_6065566_0	1347392.CCEZ01000043_gene587	1.085e-103	343.0	COG3246@1|root,COG3246@2|Bacteria,1TQNV@1239|Firmicutes,248TX@186801|Clostridia,36R3B@31979|Clostridiaceae	186801|Clostridia	S	beta-keto acid cleavage enzyme	-	-	2.3.1.247	ko:K18013	ko00310,map00310	-	R10564	RC02728,RC03199	ko00000,ko00001,ko01000	-	-	-	BKACE
HKD1_k127_6072085_1	1499689.CCNN01000007_gene1050	5.963e-63	225.0	COG0726@1|root,COG0726@2|Bacteria,1TYRH@1239|Firmicutes,24BM4@186801|Clostridia,36VG1@31979|Clostridiaceae	186801|Clostridia	G	Polysaccharide deacetylase	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_deac_1
HKD1_k127_6072085_2	997350.HMPREF9129_2059	5.999e-16	83.0	COG1302@1|root,COG1302@2|Bacteria,1V4IC@1239|Firmicutes,24JNM@186801|Clostridia	186801|Clostridia	S	protein conserved in bacteria	asp	-	-	-	-	-	-	-	-	-	-	-	Asp23
HKD1_k127_6072085_0	1230342.CTM_01779	7.485e-78	269.0	COG1388@1|root,COG3773@1|root,COG1388@2|Bacteria,COG3773@2|Bacteria,1TSZ4@1239|Firmicutes,24C40@186801|Clostridia,36ECA@31979|Clostridiaceae	186801|Clostridia	M	cell wall hydrolase	-	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2,LysM
HKD1_k127_6086864_2	1304284.L21TH_2554	4.477e-77	268.0	COG1195@1|root,COG1195@2|Bacteria,1TP9U@1239|Firmicutes,247KY@186801|Clostridia,36DP1@31979|Clostridiaceae	186801|Clostridia	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD1_k127_6086864_1	1304284.L21TH_2556	1.561e-304	943.0	COG0187@1|root,COG0187@2|Bacteria,1TQ0R@1239|Firmicutes,248AV@186801|Clostridia,36DYE@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD1_k127_6086864_0	1304284.L21TH_2557	1.073e-305	948.0	COG0188@1|root,COG0188@2|Bacteria,1TP2Z@1239|Firmicutes,2482G@186801|Clostridia,36E5Z@31979|Clostridiaceae	186801|Clostridia	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD1_k127_6096871_1	1235790.C805_03560	1.176e-64	226.0	COG4656@1|root,COG4656@2|Bacteria,1TPCC@1239|Firmicutes,24805@186801|Clostridia,25URU@186806|Eubacteriaceae	186801|Clostridia	C	RnfC Barrel sandwich hybrid domain	-	-	-	-	-	-	-	-	-	-	-	-	Complex1_51K,Fer4_17,RnfC_N,SLBB
HKD1_k127_6096871_0	411902.CLOBOL_07224	2.019e-100	334.0	arCOG04584@1|root,2ZYP7@2|Bacteria,1TQAQ@1239|Firmicutes,24APY@186801|Clostridia,221TC@1506553|Lachnoclostridium	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6096871_2	742738.HMPREF9460_01164	2.635e-55	199.0	COG4577@1|root,COG4577@2|Bacteria,1UKDS@1239|Firmicutes,24IS5@186801|Clostridia,269KZ@186813|unclassified Clostridiales	186801|Clostridia	CQ	BMC domain	csoS1C	-	-	-	-	-	-	-	-	-	-	-	BMC
HKD1_k127_6096871_3	190304.FN1412	3.926e-05	48.0	COG4857@1|root,COG4857@2|Bacteria,379JH@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate	mtnK	-	2.7.1.100	ko:K00899	ko00270,ko01100,map00270,map01100	M00034	R04143	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HKD1_k127_6112891_3	1304284.L21TH_1219	1.118e-60	212.0	COG0126@1|root,COG0126@2|Bacteria,1TP3H@1239|Firmicutes,248VS@186801|Clostridia,36ETN@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the phosphoglycerate kinase family	pgk	-	2.7.2.3,5.3.1.1	ko:K00927,ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01015,R01512	RC00002,RC00043,RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD1_k127_6112891_2	1121289.JHVL01000018_gene622	1.625e-95	318.0	COG0149@1|root,COG0149@2|Bacteria,1TP2F@1239|Firmicutes,248JN@186801|Clostridia,36DIA@31979|Clostridiaceae	186801|Clostridia	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS19265	TIM
HKD1_k127_6112891_0	1304284.L21TH_1217	3.666e-208	658.0	COG0696@1|root,COG0696@2|Bacteria,1TPM4@1239|Firmicutes,247JG@186801|Clostridia,36EXB@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate	gpmI	-	5.4.2.12	ko:K15633	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000	-	-	-	Metalloenzyme,Phosphodiest,iPGM_N
HKD1_k127_6112891_1	1347392.CCEZ01000018_gene1119	6.691e-150	477.0	COG0148@1|root,COG0148@2|Bacteria,1TP2S@1239|Firmicutes,247TU@186801|Clostridia,36ET7@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD1_k127_6141182_0	1121289.JHVL01000001_gene1836	4.201e-105	355.0	COG0475@1|root,COG0475@2|Bacteria,1TS32@1239|Firmicutes,247XW@186801|Clostridia,36DM6@31979|Clostridiaceae	186801|Clostridia	P	Transporter, CPA2 family	napA	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD1_k127_6141182_1	1123326.JFBL01000001_gene1370	8.282e-09	57.0	COG1036@1|root,COG5015@1|root,COG1036@2|Bacteria,COG5015@2|Bacteria,1NWDW@1224|Proteobacteria	1224|Proteobacteria	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6156929_2	1227352.C173_19076	7.424e-07	56.0	COG3210@1|root,COG5492@1|root,COG3210@2|Bacteria,COG5492@2|Bacteria,1UIQ6@1239|Firmicutes,4HHN7@91061|Bacilli,26T35@186822|Paenibacillaceae	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	Big_2,DUF3863,SLH
HKD1_k127_6156929_1	1304284.L21TH_2447	1.163e-32	133.0	2E366@1|root,32Y5Z@2|Bacteria,1VFY1@1239|Firmicutes,24RE8@186801|Clostridia,36KIH@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6156929_0	1391646.AVSU01000040_gene1900	3.901e-66	234.0	28IAA@1|root,2Z8CW@2|Bacteria,1TQHP@1239|Firmicutes,25I5B@186801|Clostridia,25TC7@186804|Peptostreptococcaceae	186801|Clostridia	S	DHHW protein	-	-	-	-	-	-	-	-	-	-	-	-	DHHW
HKD1_k127_6158442_0	350688.Clos_0979	5.25e-218	683.0	COG0514@1|root,COG0514@2|Bacteria,1TPN5@1239|Firmicutes,247ZA@186801|Clostridia,36DC9@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent DNA helicase RecQ	recQ	-	3.6.4.12	ko:K03654	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,HRDC,HTH_40,Helicase_C,RQC,RecQ_Zn_bind
HKD1_k127_6179279_1	457396.CSBG_01641	2.154e-55	199.0	COG1597@1|root,COG1597@2|Bacteria,1V1DP@1239|Firmicutes,25CN2@186801|Clostridia,36HD9@31979|Clostridiaceae	186801|Clostridia	I	Diacylglycerol kinase catalytic domain (presumed)	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD1_k127_6179279_0	903814.ELI_1693	2.633e-79	271.0	COG0745@1|root,COG0745@2|Bacteria,1TPU2@1239|Firmicutes,25B20@186801|Clostridia,25V2G@186806|Eubacteriaceae	186801|Clostridia	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6179279_2	931626.Awo_c13620	7.02e-38	155.0	COG5002@1|root,COG5002@2|Bacteria,1TS83@1239|Firmicutes,249CD@186801|Clostridia,25VHW@186806|Eubacteriaceae	186801|Clostridia	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_6211853_3	1449050.JNLE01000003_gene2282	1.125e-71	247.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,36DQ7@31979|Clostridiaceae	186801|Clostridia	C	L-lactate permease	lctP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HKD1_k127_6211853_2	357809.Cphy_1315	1.06e-134	432.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,21XTI@1506553|Lachnoclostridium	186801|Clostridia	C	Electron transfer flavoprotein	etfB1	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_6211853_0	1163671.JAGI01000002_gene1678	1.206e-205	644.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36DD9@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein	etfA2	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD1_k127_6211853_1	1163671.JAGI01000002_gene1679	4.761e-199	623.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36DRC@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidase domain protein	glcD1	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_6212838_1	1209989.TepiRe1_0303	1.901e-26	113.0	COG2893@1|root,COG2893@2|Bacteria,1VG0G@1239|Firmicutes,24SWY@186801|Clostridia,42H4D@68295|Thermoanaerobacterales	186801|Clostridia	G	PFAM PTS system fructose subfamily IIA component	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
HKD1_k127_6212838_0	484770.UFO1_0311	8.392e-31	127.0	COG3444@1|root,COG3444@2|Bacteria,1V694@1239|Firmicutes,4H5J5@909932|Negativicutes	909932|Negativicutes	G	PFAM PTS system sorbose subfamily IIB component	-	-	2.7.1.191	ko:K02794	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	PTSIIB_sorb
HKD1_k127_6212838_2	1499684.CCNP01000018_gene1801	7.826e-18	89.0	COG3715@1|root,COG3715@2|Bacteria,1V7ZR@1239|Firmicutes,25C3K@186801|Clostridia	186801|Clostridia	G	PTS system sorbose-specific iic component	-	-	-	ko:K02795,ko:K17466	ko00030,ko00051,ko00520,ko01100,ko01120,ko02060,map00030,map00051,map00520,map01100,map01120,map02060	M00276,M00610	R02630,R10407	RC00017,RC03206	ko00000,ko00001,ko00002,ko02000	4.A.6.1,4.A.6.1.17	-	-	EII-Sor
HKD1_k127_6213814_5	445971.ANASTE_01053	2.146e-29	121.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,25VVG@186806|Eubacteriaceae	186801|Clostridia	E	Psort location CytoplasmicMembrane, score	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6213814_4	635013.TherJR_2666	7.535e-107	351.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,261BH@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter related	-	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6213814_2	1280692.AUJL01000038_gene332	1.313e-146	472.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,36DQT@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6213814_3	1280692.AUJL01000038_gene331	1.603e-134	434.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,36DZ6@31979|Clostridiaceae	186801|Clostridia	U	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6213814_1	1280692.AUJL01000038_gene330	1.2e-174	556.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,36DTA@31979|Clostridiaceae	186801|Clostridia	E	PFAM Extracellular ligand-binding receptor	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6213814_0	865861.AZSU01000003_gene1586	1.63e-189	599.0	COG0112@1|root,COG0112@2|Bacteria,1TQVM@1239|Firmicutes,248W5@186801|Clostridia,36EMY@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD1_k127_6216843_1	1415775.U729_2381	8.952e-23	98.0	COG3437@1|root,COG3437@2|Bacteria,1TQ0S@1239|Firmicutes,24800@186801|Clostridia,36E1T@31979|Clostridiaceae	186801|Clostridia	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF,HD,HD_5
HKD1_k127_6216843_0	1487923.DP73_21405	5.217e-76	264.0	COG0778@1|root,COG0778@2|Bacteria,1V0NJ@1239|Firmicutes,24FM7@186801|Clostridia,261PI@186807|Peptococcaceae	186801|Clostridia	C	PFAM Nitroreductase family	-	-	-	-	-	-	-	-	-	-	-	-	TM1586_NiRdase
HKD1_k127_6228591_3	720554.Clocl_1413	6.944e-09	59.0	COG4974@1|root,COG4974@2|Bacteria,1TQST@1239|Firmicutes,247YT@186801|Clostridia,3WHKJ@541000|Ruminococcaceae	186801|Clostridia	L	PFAM Transposase IS66 family	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
HKD1_k127_6228591_0	553973.CLOHYLEM_06601	4.371e-233	725.0	COG0477@1|root,COG2814@2|Bacteria,1VNR0@1239|Firmicutes	1239|Firmicutes	EGP	of the major facilitator superfamily	ydiN1	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD1_k127_6228591_2	553973.CLOHYLEM_06600	5.222e-13	69.0	COG0169@1|root,COG0169@2|Bacteria,1TQRY@1239|Firmicutes,2497S@186801|Clostridia,21XW8@1506553|Lachnoclostridium	186801|Clostridia	E	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)	aroE	-	1.1.1.25	ko:K00014	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02413	RC00206	ko00000,ko00001,ko00002,ko01000	-	-	-	Shikimate_DH,Shikimate_dh_N
HKD1_k127_6228591_4	411462.DORLON_00706	1.606e-06	50.0	COG1082@1|root,COG1082@2|Bacteria,1TT50@1239|Firmicutes,248RM@186801|Clostridia	186801|Clostridia	G	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_6228591_1	411468.CLOSCI_00698	7.031e-123	400.0	COG0583@1|root,COG0583@2|Bacteria,1TRVX@1239|Firmicutes,24B1W@186801|Clostridia,220PU@1506553|Lachnoclostridium	186801|Clostridia	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD1_k127_6231224_2	1118055.CAGU01000036_gene1339	6.2e-23	98.0	COG2233@1|root,COG2233@2|Bacteria,1TNZZ@1239|Firmicutes,25CEM@186801|Clostridia,22GCK@1570339|Peptoniphilaceae	186801|Clostridia	F	permease	-	-	-	ko:K03458	-	-	-	-	ko00000	2.A.40	-	-	Xan_ur_permease
HKD1_k127_6231224_1	596324.TREVI0001_0113	9.237e-114	382.0	COG0044@1|root,COG0044@2|Bacteria,2J6KK@203691|Spirochaetes	203691|Spirochaetes	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	hydA	-	3.5.2.2	ko:K01464	ko00240,ko00410,ko00770,ko00983,ko01100,map00240,map00410,map00770,map00983,map01100	M00046	R02269,R03055,R08227	RC00632,RC00680	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Amidohydro_1
HKD1_k127_6231224_0	1196322.A370_02826	0.0	1210.0	COG1529@1|root,COG2080@1|root,COG1529@2|Bacteria,COG2080@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,36DY8@31979|Clostridiaceae	186801|Clostridia	C	aldehyde oxidase and xanthine dehydrogenase, a b hammerhead	-	-	-	-	-	-	-	-	-	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2,Fer2_3
HKD1_k127_6243364_7	1408422.JHYF01000010_gene3360	3.134e-05	48.0	28ZXE@1|root,2ZMMW@2|Bacteria,1W5NQ@1239|Firmicutes,255B1@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6243364_1	1120998.AUFC01000001_gene1837	1.675e-182	578.0	COG0683@1|root,COG0683@2|Bacteria,1TPQ2@1239|Firmicutes,248H1@186801|Clostridia,3WCVN@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid amide ABC transporter substrate-binding protein, HAAT family	-	-	-	ko:K01999	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	Peripla_BP_6
HKD1_k127_6243364_3	1120998.AUFC01000001_gene1838	1.803e-143	459.0	COG0559@1|root,COG0559@2|Bacteria,1TR24@1239|Firmicutes,2480A@186801|Clostridia,3WCV8@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid amide ABC transporter membrane protein 1, HAAT family	livH	-	-	ko:K01997	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6243364_2	1120998.AUFC01000001_gene1839	6.998e-149	477.0	COG4177@1|root,COG4177@2|Bacteria,1TPMZ@1239|Firmicutes,248WH@186801|Clostridia,3WCX2@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid amide ABC transporter membrane protein 2, HAAT family	livM	-	-	ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	BPD_transp_2
HKD1_k127_6243364_4	1120998.AUFC01000001_gene1840	5.068e-132	424.0	COG0411@1|root,COG0411@2|Bacteria,1TR0P@1239|Firmicutes,2490B@186801|Clostridia,3WCU3@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid amide ABC transporter ATP-binding protein 1, HAAT family	livG	-	-	ko:K01995	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6243364_5	445971.ANASTE_01053	1.026e-92	309.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,25VVG@186806|Eubacteriaceae	186801|Clostridia	E	Psort location CytoplasmicMembrane, score	livF	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C
HKD1_k127_6243364_6	1120998.AUFC01000001_gene1842	3.774e-91	304.0	COG0517@1|root,COG0517@2|Bacteria,1V0XU@1239|Firmicutes,24I2P@186801|Clostridia	186801|Clostridia	S	CBS domain containing protein	acuB	-	-	ko:K04767	-	-	-	-	ko00000	-	-	-	ACT,CBS
HKD1_k127_6243364_0	469617.FUAG_00403	1.803e-277	865.0	COG1506@1|root,COG1506@2|Bacteria,378NX@32066|Fusobacteria	32066|Fusobacteria	E	Prolyl oligopeptidase family	-	-	3.4.19.1	ko:K01303	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S9
HKD1_k127_6260021_1	158190.SpiGrapes_0215	2.709e-58	215.0	COG2199@1|root,COG2199@2|Bacteria,2J7TH@203691|Spirochaetes	203691|Spirochaetes	T	TIGRFAM Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD1_k127_6260021_0	411461.DORFOR_00105	1.221e-163	526.0	COG1305@1|root,COG1305@2|Bacteria,1TT33@1239|Firmicutes,24B27@186801|Clostridia	186801|Clostridia	E	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core
HKD1_k127_6270290_2	1121289.JHVL01000009_gene1479	4.329e-12	67.0	COG0628@1|root,COG0628@2|Bacteria,1TQ84@1239|Firmicutes,248FS@186801|Clostridia,36EE4@31979|Clostridiaceae	186801|Clostridia	S	hmm pf01594	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD1_k127_6270290_0	1449050.JNLE01000003_gene2831	7.813e-171	544.0	COG2195@1|root,COG2195@2|Bacteria,1TP3A@1239|Firmicutes,248JJ@186801|Clostridia,36EEA@31979|Clostridiaceae	186801|Clostridia	E	Cleaves the N-terminal amino acid of tripeptides	pepT	-	3.4.11.4	ko:K01258	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M42
HKD1_k127_6270290_1	180332.JTGN01000001_gene5054	8.717e-66	231.0	COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia	186801|Clostridia	C	PFAM Uncharacterised ACR, YkgG family COG1556	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
HKD1_k127_6270351_0	1321778.HMPREF1982_04585	1.426e-147	471.0	COG2608@1|root,COG2836@1|root,COG4633@1|root,COG2608@2|Bacteria,COG2836@2|Bacteria,COG4633@2|Bacteria,1TQ02@1239|Firmicutes,249HC@186801|Clostridia,2682N@186813|unclassified Clostridiales	186801|Clostridia	P	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1,DsbD_2,HMA
HKD1_k127_6289539_1	1511.CLOST_1294	1.613e-68	233.0	COG3804@1|root,COG3804@2|Bacteria,1TRNF@1239|Firmicutes,249AS@186801|Clostridia,25SYT@186804|Peptostreptococcaceae	186801|Clostridia	S	dihydrodipicolinate reductase	ord	GO:0003674,GO:0003824,GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0047530,GO:0055114,GO:0071704,GO:1901564,GO:1901605	1.4.1.12,1.4.1.26	ko:K21672	ko00310,ko00330,ko00472,map00310,map00330,map00472	-	R02825,R04200,R04201,R04687,R04688	RC00249,RC00790	ko00000,ko00001,ko01000	-	-	-	DapB_N
HKD1_k127_6289539_2	1123009.AUID01000004_gene1524	3.749e-46	168.0	2E6IF@1|root,3315M@2|Bacteria,1VAX0@1239|Firmicutes,24N55@186801|Clostridia,269W7@186813|unclassified Clostridiales	186801|Clostridia	-	-	ortA	GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	2.3.1.263	ko:K21399	-	-	-	-	ko00000,ko01000	-	-	-	-
HKD1_k127_6289539_0	1511.CLOST_1292	2.16e-229	717.0	COG0031@1|root,COG0031@2|Bacteria	2|Bacteria	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	GO:0006082,GO:0006520,GO:0006591,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0071704,GO:1901564,GO:1901605	2.3.1.263,2.5.1.47	ko:K01738,ko:K12339,ko:K21400	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03132,R03601,R04859	RC00020,RC02814,RC02821,RC02876	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD1_k127_6298488_1	931626.Awo_c32790	2.254e-185	589.0	COG0403@1|root,COG0403@2|Bacteria,1TQGG@1239|Firmicutes,2492A@186801|Clostridia,25V3E@186806|Eubacteriaceae	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD1_k127_6298488_3	1195236.CTER_4058	2.719e-42	159.0	COG0509@1|root,COG0509@2|Bacteria,1V6WV@1239|Firmicutes,24N5H@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD1_k127_6298488_2	1195236.CTER_4059	4.967e-148	477.0	COG0404@1|root,COG0404@2|Bacteria,1TRKX@1239|Firmicutes,248U7@186801|Clostridia	186801|Clostridia	E	The glycine cleavage system catalyzes the degradation of glycine	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD1_k127_6298488_0	2754.EH55_09280	6.511e-304	935.0	COG4799@1|root,COG4799@2|Bacteria,3TAED@508458|Synergistetes	508458|Synergistetes	I	PFAM carboxyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Carboxyl_trans
HKD1_k127_6301734_0	1304284.L21TH_1332	1.524e-194	615.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD1_k127_6305620_0	97138.C820_02183	6.088e-229	715.0	COG0334@1|root,COG0334@2|Bacteria,1TP45@1239|Firmicutes,24960@186801|Clostridia,36EGU@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the Glu Leu Phe Val dehydrogenases family	gdh	GO:0003674,GO:0003824,GO:0004352,GO:0004353,GO:0006082,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016638,GO:0016639,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044281,GO:0055114,GO:0071704,GO:1901564	1.4.1.3,1.4.1.4	ko:K00261,ko:K00262	ko00220,ko00250,ko00471,ko00910,ko01100,ko01200,ko04217,ko04964,map00220,map00250,map00471,map00910,map01100,map01200,map04217,map04964	M00740	R00243,R00248	RC00006,RC02799	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD1_k127_6312227_1	748727.CLJU_c15750	2.278e-73	254.0	COG4122@1|root,COG4122@2|Bacteria,1VKRG@1239|Firmicutes,24HG7@186801|Clostridia,36P3I@31979|Clostridiaceae	186801|Clostridia	Q	Macrocin-O-methyltransferase (TylF)	-	-	-	ko:K05303	-	-	-	-	ko00000,ko01000	-	-	-	TylF
HKD1_k127_6312227_0	1499683.CCFF01000014_gene3661	2.815e-77	267.0	COG1975@1|root,COG1975@2|Bacteria,1UZDB@1239|Firmicutes,25D6N@186801|Clostridia,36U7S@31979|Clostridiaceae	186801|Clostridia	O	XdhC and CoxI family	-	-	-	ko:K07402	-	-	-	-	ko00000	-	-	-	XdhC_C,XdhC_CoxI
HKD1_k127_6337720_1	931626.Awo_c12880	1.505e-40	154.0	COG2221@1|root,COG2221@2|Bacteria,1VJJG@1239|Firmicutes,25B3T@186801|Clostridia,25XK9@186806|Eubacteriaceae	186801|Clostridia	C	Putative redox-active protein (C_GCAxxG_C_C)	-	-	-	-	-	-	-	-	-	-	-	-	C_GCAxxG_C_C
HKD1_k127_6337720_0	1128398.Curi_c06300	4.621e-137	460.0	COG0210@1|root,COG0210@2|Bacteria,1TPVG@1239|Firmicutes,2484I@186801|Clostridia,268AA@186813|unclassified Clostridiales	186801|Clostridia	L	AAA domain	-	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD1_k127_6338191_0	646529.Desaci_0741	0.0	1322.0	COG0067@1|root,COG0069@1|root,COG0070@1|root,COG0067@2|Bacteria,COG0069@2|Bacteria,COG0070@2|Bacteria,1TQ0B@1239|Firmicutes,248IB@186801|Clostridia,260N1@186807|Peptococcaceae	186801|Clostridia	E	glutamate synthase	gltB	-	1.4.1.13,1.4.1.14,1.4.7.1	ko:K00265,ko:K00284	ko00250,ko00630,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00630,map00910,map01100,map01110,map01120,map01130,map01230	-	R00021,R00093,R00114,R00248,R10086	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	GATase_2,GXGXG,Glu_syn_central,Glu_synthase
HKD1_k127_6338522_1	1304284.L21TH_2663	3.563e-84	282.0	COG0550@1|root,COG0550@2|Bacteria,1TPUS@1239|Firmicutes,248MG@186801|Clostridia,36DSI@31979|Clostridiaceae	186801|Clostridia	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,zf-C4_Topoisom
HKD1_k127_6338522_0	1476973.JMMB01000007_gene1024	6.764e-172	551.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,25S2V@186804|Peptostreptococcaceae	186801|Clostridia	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_6338522_2	1301100.HG529235_gene7304	4.299e-44	164.0	COG1846@1|root,COG1846@2|Bacteria,1VEFZ@1239|Firmicutes,24MSB@186801|Clostridia,36N2T@31979|Clostridiaceae	186801|Clostridia	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_6338522_3	1410658.JHWI01000020_gene1041	2.279e-26	113.0	COG0818@1|root,COG0818@2|Bacteria,1VEGR@1239|Firmicutes,3VREG@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Prokaryotic diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_prokar
HKD1_k127_6338522_4	755731.Clo1100_1087	7.599e-13	68.0	COG4728@1|root,COG4728@2|Bacteria,1VENJ@1239|Firmicutes,24SFD@186801|Clostridia	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF1653
HKD1_k127_6344969_1	1301100.HG529424_gene1984	9.314e-60	211.0	COG0122@1|root,COG0122@2|Bacteria,1TQAF@1239|Firmicutes,2495X@186801|Clostridia,36DTH@31979|Clostridiaceae	186801|Clostridia	L	8-oxoguanine DNA glycosylase	alkA	-	4.2.99.18	ko:K03660	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD,OGG_N
HKD1_k127_6344969_2	1120746.CCNL01000008_gene711	1.599e-52	191.0	COG1827@1|root,COG1827@2|Bacteria	2|Bacteria	K	regulation of RNA biosynthetic process	niaR	-	-	ko:K07105	-	-	-	-	ko00000	-	-	-	3H,HTH_11
HKD1_k127_6344969_0	1292035.H476_1167	7.5e-61	217.0	2A1RE@1|root,30PZZ@2|Bacteria,1V46H@1239|Firmicutes,24FU8@186801|Clostridia,25SXF@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	ko:K16788	-	-	-	-	ko00000,ko02000	2.A.88.5	-	-	-
HKD1_k127_6344969_3	332101.JIBU02000015_gene53	1.355e-32	133.0	COG0662@1|root,COG1396@1|root,COG0662@2|Bacteria,COG1396@2|Bacteria,1V1K5@1239|Firmicutes,24FTC@186801|Clostridia,36F4A@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_3
HKD1_k127_6344969_4	1408823.AXUS01000021_gene2450	4.877e-12	66.0	2EDV7@1|root,337QC@2|Bacteria,1VEH5@1239|Firmicutes,24SJC@186801|Clostridia,25U3B@186804|Peptostreptococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6345252_2	1408422.JHYF01000004_gene1722	2.297e-17	83.0	COG1142@1|root,COG1142@2|Bacteria,1VJF0@1239|Firmicutes,25HHZ@186801|Clostridia	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_4
HKD1_k127_6345252_0	1304284.L21TH_1016	1.136e-98	330.0	COG1281@1|root,COG1281@2|Bacteria,1TRCH@1239|Firmicutes,24940@186801|Clostridia,36DPJ@31979|Clostridiaceae	186801|Clostridia	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD1_k127_6345252_1	1304284.L21TH_1014	4.014e-52	193.0	COG2227@1|root,COG2227@2|Bacteria,1V218@1239|Firmicutes,25EUC@186801|Clostridia,36UUN@31979|Clostridiaceae	186801|Clostridia	H	Nodulation protein S (NodS)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD1_k127_6345252_3	1304284.L21TH_1004	5.932e-16	79.0	2EIJI@1|root,33CAV@2|Bacteria,1VK5E@1239|Firmicutes,24MMQ@186801|Clostridia,36KUX@31979|Clostridiaceae	186801|Clostridia	S	Small, acid-soluble spore proteins, alpha/beta type	-	-	-	-	-	-	-	-	-	-	-	-	SASP
HKD1_k127_6347155_0	1120998.AUFC01000020_gene334	1.717e-54	197.0	COG1595@1|root,COG1595@2|Bacteria,1VGKP@1239|Firmicutes,24RUX@186801|Clostridia	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6351011_2	865861.AZSU01000010_gene725	9.873e-52	184.0	COG0008@1|root,COG0008@2|Bacteria,1TPJC@1239|Firmicutes,2482P@186801|Clostridia,36E95@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX	-	6.1.1.17,6.1.1.24	ko:K01885,ko:K09698	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R03651,R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD1_k127_6351011_0	1031288.AXAA01000015_gene303	1.575e-163	523.0	COG0281@1|root,COG0281@2|Bacteria,1TPJ3@1239|Firmicutes,2487U@186801|Clostridia,36DTC@31979|Clostridiaceae	186801|Clostridia	C	malic enzyme	-	-	1.1.1.38	ko:K00027	ko00620,ko01200,ko02020,map00620,map01200,map02020	-	R00214	RC00105	ko00000,ko00001,ko01000	-	-	-	Malic_M,malic
HKD1_k127_6351011_1	1410668.JNKC01000004_gene258	1.897e-91	306.0	COG0165@1|root,COG0165@2|Bacteria,1TNZ6@1239|Firmicutes,2489H@186801|Clostridia,36E9J@31979|Clostridiaceae	186801|Clostridia	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD1_k127_6353932_2	1526927.Plano_0588	6.408e-21	94.0	COG5002@1|root,COG5002@2|Bacteria,1TS83@1239|Firmicutes,4ISRX@91061|Bacilli,26FJV@186818|Planococcaceae	91061|Bacilli	T	histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD1_k127_6353932_1	1354300.AUQY01000004_gene10	2.042e-73	255.0	COG0061@1|root,COG0061@2|Bacteria,1TRB3@1239|Firmicutes,24BG6@186801|Clostridia,22HAY@1570339|Peptoniphilaceae	186801|Clostridia	H	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	nadK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS05480	NAD_kinase
HKD1_k127_6353932_0	1128398.Curi_c09680	3.845e-88	299.0	COG0564@1|root,COG0564@2|Bacteria,1TS1T@1239|Firmicutes,249AH@186801|Clostridia,268XS@186813|unclassified Clostridiales	186801|Clostridia	J	RNA pseudouridylate synthase	rluA	-	5.4.99.23,5.4.99.28,5.4.99.29	ko:K06177,ko:K06180	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD1_k127_6358205_0	1410653.JHVC01000014_gene3363	4.702e-60	209.0	2AIX9@1|root,319EX@2|Bacteria,1V7X2@1239|Firmicutes,24J87@186801|Clostridia,36JYE@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6358205_1	1321778.HMPREF1982_02605	4.776e-48	181.0	COG0500@1|root,COG0500@2|Bacteria,1UIH0@1239|Firmicutes,25HFV@186801|Clostridia	186801|Clostridia	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6358205_2	1321778.HMPREF1982_02934	2.826e-42	157.0	2E49F@1|root,32Z57@2|Bacteria,1VA75@1239|Firmicutes,24NSI@186801|Clostridia,269KM@186813|unclassified Clostridiales	186801|Clostridia	S	Domain of unknown function (DUF4180)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4180
HKD1_k127_6358205_3	871963.Desdi_0378	8.735e-18	89.0	2EBC9@1|root,335CZ@2|Bacteria,1VIFY@1239|Firmicutes,24TMK@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_635911_1	397288.C806_03056	1.636e-113	370.0	COG0427@1|root,COG0427@2|Bacteria,1TPHC@1239|Firmicutes,247V0@186801|Clostridia,27K75@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Acetyl-CoA hydrolase/transferase C-terminal domain	cat	-	-	-	-	-	-	-	-	-	-	-	AcetylCoA_hyd_C,AcetylCoA_hydro
HKD1_k127_635911_3	717605.Theco_2156	1.265e-14	78.0	COG0011@1|root,COG0011@2|Bacteria,1VBWM@1239|Firmicutes,4HKDU@91061|Bacilli,26YAM@186822|Paenibacillaceae	91061|Bacilli	S	Thiamine-binding protein	M1-594	-	-	-	-	-	-	-	-	-	-	-	Thiamine_BP
HKD1_k127_635911_0	1449050.JNLE01000003_gene1394	7.333e-115	374.0	COG0600@1|root,COG0600@2|Bacteria,1TRFD@1239|Firmicutes,25C7Z@186801|Clostridia,36DV8@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport system, permease component	-	-	-	-	-	-	-	-	-	-	-	-	BPD_transp_1
HKD1_k127_635911_2	1449050.JNLE01000003_gene1395	2.656e-112	368.0	COG0715@1|root,COG0715@2|Bacteria,1TPAD@1239|Firmicutes,24A2V@186801|Clostridia,36FHT@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	-	-	-	-	-	-	-	-	-	NMT1
HKD1_k127_6360544_0	1089553.Tph_c23410	8.702e-71	241.0	COG0489@1|root,COG0489@2|Bacteria,1TQ34@1239|Firmicutes,24817@186801|Clostridia,42EY7@68295|Thermoanaerobacterales	186801|Clostridia	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	mrp	-	-	-	-	-	-	-	-	-	-	-	ParA
HKD1_k127_6360544_2	1487921.DP68_15765	1.742e-46	170.0	COG1433@1|root,COG1433@2|Bacteria,1VW1T@1239|Firmicutes,24KHS@186801|Clostridia,36K7N@31979|Clostridiaceae	186801|Clostridia	K	Dinitrogenase iron-molybdenum cofactor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_5,Nitro_FeMo-Co
HKD1_k127_6360544_3	1195236.CTER_1143	3.599e-45	167.0	COG0239@1|root,COG0239@2|Bacteria,1VEH7@1239|Firmicutes,24QSV@186801|Clostridia,3WKIG@541000|Ruminococcaceae	186801|Clostridia	U	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD1_k127_6360544_1	981383.AEWH01000050_gene106	1.714e-53	195.0	COG4300@1|root,COG4300@2|Bacteria,1TPQX@1239|Firmicutes,4IRGY@91061|Bacilli	91061|Bacilli	P	Cadmium resistance transporter	-	-	-	-	-	-	-	-	-	-	-	-	Cad
HKD1_k127_6360544_4	1128398.Curi_c27590	0.0003314	43.0	COG1733@1|root,COG1733@2|Bacteria,1VA9M@1239|Firmicutes,24KBG@186801|Clostridia	186801|Clostridia	K	transcriptional regulator	hxlR	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD1_k127_6361953_1	871963.Desdi_0104	3.109e-103	341.0	COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia	186801|Clostridia	P	Catalyzes the sodium-dependent transport of glutamate	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HKD1_k127_6361953_0	865861.AZSU01000007_gene1078	1.82e-139	447.0	COG0161@1|root,COG0161@2|Bacteria,1TP9N@1239|Firmicutes,25E7B@186801|Clostridia,36W8D@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor	bioA	-	2.6.1.113,2.6.1.55,2.6.1.62,2.6.1.77	ko:K00833,ko:K03851,ko:K12256,ko:K15372	ko00330,ko00410,ko00430,ko00780,ko01100,map00330,map00410,map00430,map00780,map01100	M00123,M00573,M00577	R00908,R01684,R03231,R05652,R08714	RC00006,RC00008,RC00062,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_6371811_1	1511.CLOST_0991	3.803e-84	286.0	COG2243@1|root,COG2243@2|Bacteria,1TP87@1239|Firmicutes,249DM@186801|Clostridia,25RC1@186804|Peptostreptococcaceae	186801|Clostridia	H	Precorrin-2 C(20)-methyltransferase	cobI	-	2.1.1.130,2.1.1.151	ko:K03394	ko00860,ko01100,map00860,map01100	-	R03948,R05808	RC00003,RC01035,RC01662	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_6371811_0	1476973.JMMB01000007_gene513	5.707e-99	327.0	COG1010@1|root,COG1010@2|Bacteria,1TPJ7@1239|Firmicutes,247QS@186801|Clostridia,25QEW@186804|Peptostreptococcaceae	186801|Clostridia	H	precorrin-3B C17-methyltransferase	cobJ	-	2.1.1.131,2.1.1.272	ko:K05934,ko:K21479	ko00860,ko01100,map00860,map01100	-	R05180,R05809,R11580	RC00003,RC01293,RC03471,RC03479	ko00000,ko00001,ko01000	-	-	-	TP_methylase
HKD1_k127_6371811_2	1511.CLOST_0996	9.077e-81	274.0	COG0373@1|root,COG0373@2|Bacteria,1TQN9@1239|Firmicutes,2496M@186801|Clostridia,25QCT@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)	hemA	-	1.2.1.70	ko:K02492	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R04109	RC00055,RC00149	ko00000,ko00001,ko00002,ko01000	-	-	-	GlutR_N,GlutR_dimer,Shikimate_DH
HKD1_k127_6385163_0	1121289.JHVL01000009_gene1464	2.337e-144	465.0	COG0533@1|root,COG0533@2|Bacteria,1TQDR@1239|Firmicutes,247MG@186801|Clostridia,36DHM@31979|Clostridiaceae	186801|Clostridia	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD1_k127_6385163_1	1121289.JHVL01000009_gene1466	4.883e-60	213.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,36E7X@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_6394178_0	1128398.Curi_c12160	9.46e-175	559.0	COG0028@1|root,COG0028@2|Bacteria,1TQE8@1239|Firmicutes,2480U@186801|Clostridia,26ANK@186813|unclassified Clostridiales	186801|Clostridia	EH	Thiamine pyrophosphate enzyme, central domain	ilvB2	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD1_k127_6400003_0	1121090.KB894688_gene1820	1.341e-178	567.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,4HABX@91061|Bacilli,1ZBQE@1386|Bacillus	91061|Bacilli	E	Belongs to the AlaDH PNT family	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_6400003_1	1499683.CCFF01000017_gene2249	0.0004132	44.0	COG0686@1|root,COG0686@2|Bacteria,1TNZ5@1239|Firmicutes,2489D@186801|Clostridia,36FMI@31979|Clostridiaceae	186801|Clostridia	E	Alanine dehydrogenase/PNT, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD1_k127_6403101_1	1408312.JNJS01000002_gene342	1.814e-85	285.0	COG0652@1|root,COG0652@2|Bacteria,1TRHW@1239|Firmicutes,247XN@186801|Clostridia,3NGHM@46205|Pseudobutyrivibrio	186801|Clostridia	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	ppiB	-	5.2.1.8	ko:K03768	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Pro_isomerase
HKD1_k127_6403101_0	1347392.CCEZ01000076_gene1677	4.236e-114	376.0	28M06@1|root,2ZAFA@2|Bacteria,1UZ23@1239|Firmicutes,24BPA@186801|Clostridia,36GZ0@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6403526_0	203119.Cthe_0665	2.462e-100	338.0	COG0330@1|root,COG0330@2|Bacteria,1TPXU@1239|Firmicutes,24AF9@186801|Clostridia,3WNDD@541000|Ruminococcaceae	186801|Clostridia	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD1_k127_6407505_2	1120934.KB894440_gene5719	5.466e-32	126.0	COG0468@1|root,COG0468@2|Bacteria,2GJ4P@201174|Actinobacteria,4DZ5K@85010|Pseudonocardiales	201174|Actinobacteria	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	GO:0000150,GO:0000166,GO:0000287,GO:0000725,GO:0003674,GO:0003676,GO:0003677,GO:0003697,GO:0003824,GO:0004518,GO:0004519,GO:0004520,GO:0004536,GO:0005488,GO:0005524,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006259,GO:0006281,GO:0006310,GO:0006725,GO:0006807,GO:0006950,GO:0006974,GO:0007154,GO:0008094,GO:0008144,GO:0008150,GO:0008152,GO:0009314,GO:0009411,GO:0009416,GO:0009432,GO:0009605,GO:0009628,GO:0009650,GO:0009987,GO:0009991,GO:0016462,GO:0016787,GO:0016788,GO:0016817,GO:0016818,GO:0016887,GO:0017076,GO:0017111,GO:0030145,GO:0030554,GO:0031668,GO:0032553,GO:0032555,GO:0032559,GO:0033554,GO:0034641,GO:0035639,GO:0036094,GO:0042148,GO:0042221,GO:0042623,GO:0043167,GO:0043168,GO:0043169,GO:0043170,GO:0044237,GO:0044238,GO:0044260,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0046677,GO:0046872,GO:0046914,GO:0050896,GO:0051716,GO:0071496,GO:0071704,GO:0090304,GO:0090305,GO:0097159,GO:0097367,GO:0140097,GO:1901265,GO:1901360,GO:1901363	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD1_k127_6407505_1	903814.ELI_2598	1.959e-34	136.0	COG0433@1|root,COG0433@2|Bacteria,1TR1F@1239|Firmicutes,24BT8@186801|Clostridia	186801|Clostridia	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HKD1_k127_6407505_0	509191.AEDB02000022_gene2984	6.705e-165	524.0	COG0433@1|root,COG0433@2|Bacteria,1TR1F@1239|Firmicutes,24BT8@186801|Clostridia,3WHQ5@541000|Ruminococcaceae	186801|Clostridia	S	Bacterial protein of unknown function (DUF853)	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853
HKD1_k127_6409910_1	1123009.AUID01000009_gene533	6.991e-40	154.0	COG2984@1|root,COG2984@2|Bacteria,1TPB0@1239|Firmicutes,248X3@186801|Clostridia,267YK@186813|unclassified Clostridiales	186801|Clostridia	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD1_k127_6409910_0	350688.Clos_2703	9.912e-116	379.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia,36EMV@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
HKD1_k127_6409910_2	596330.HMPREF0628_0106	6.068e-15	75.0	COG1101@1|root,COG1101@2|Bacteria,1TPAN@1239|Firmicutes,247WW@186801|Clostridia,22H0K@1570339|Peptoniphilaceae	186801|Clostridia	S	ABC transporter, ATP-binding protein	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
HKD1_k127_6414469_0	332101.JIBU02000005_gene402	1.512e-162	514.0	28H7K@1|root,2Z7JT@2|Bacteria,1UPH1@1239|Firmicutes,249YA@186801|Clostridia,36DRU@31979|Clostridiaceae	186801|Clostridia	P	2-keto-3-deoxygluconate permease	kdgT	-	-	ko:K02526	-	-	-	-	ko00000,ko02000	2.A.10.1	-	-	KdgT
HKD1_k127_6415500_0	1304284.L21TH_1834	3.795e-103	348.0	COG1459@1|root,COG1459@2|Bacteria,1TQRZ@1239|Firmicutes,249FV@186801|Clostridia,36EIA@31979|Clostridiaceae	186801|Clostridia	NU	Type II secretion system	tapC	-	-	ko:K02653	-	-	-	-	ko00000,ko02035,ko02044	3.A.15.2	-	-	T2SSF
HKD1_k127_6415500_1	335541.Swol_0534	1.258e-07	59.0	COG4968@1|root,COG4968@2|Bacteria,1VD7G@1239|Firmicutes	1239|Firmicutes	NU	Prepilin-type N-terminal cleavage methylation domain	-	-	-	ko:K02456,ko:K02650	ko02020,ko03070,ko05111,map02020,map03070,map05111	M00331	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.15,3.A.15.2	-	-	N_methyl,T2SSG
HKD1_k127_6416571_2	1304284.L21TH_1760	7.296e-79	275.0	COG5002@1|root,COG5002@2|Bacteria,1TQ1H@1239|Firmicutes,247VG@186801|Clostridia,36DIS@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	yycG	-	2.7.13.3	ko:K07652	ko02020,map02020	M00459	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_8,PAS_9
HKD1_k127_6416571_1	1304284.L21TH_1759	1.399e-85	288.0	COG0745@1|root,COG0745@2|Bacteria,1TPQG@1239|Firmicutes,248Z4@186801|Clostridia,36W97@31979|Clostridiaceae	186801|Clostridia	T	PFAM response regulator receiver	walR	-	-	ko:K07658,ko:K07668	ko02020,map02020	M00434,M00459	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD1_k127_6416571_0	1304284.L21TH_1757	8.012e-125	411.0	COG1404@1|root,COG1404@2|Bacteria,1TQRU@1239|Firmicutes,249H1@186801|Clostridia,36FNC@31979|Clostridiaceae	186801|Clostridia	O	peptidase S8 and S53, subtilisin, kexin, sedolisin	aprX	-	-	ko:K17734	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S8
HKD1_k127_641905_1	357809.Cphy_1735	1.052e-47	173.0	COG1143@1|root,COG1143@2|Bacteria,1VDBV@1239|Firmicutes,25DXU@186801|Clostridia	186801|Clostridia	C	PFAM 4Fe-4S ferredoxin iron-sulfur binding domain protein	-	-	-	ko:K14091	-	-	-	-	ko00000	-	-	-	Fer4,Fer4_7
HKD1_k127_641905_0	203119.Cthe_3020	1.565e-195	613.0	COG3261@1|root,COG3261@2|Bacteria,1VZGX@1239|Firmicutes,248UJ@186801|Clostridia,3WHV8@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the complex I 49 kDa subunit family	-	-	1.6.5.3	ko:K00333,ko:K14090	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa,NiFeSe_Hases
HKD1_k127_641905_2	1304866.K413DRAFT_4400	2.02e-36	139.0	COG0852@1|root,COG0852@2|Bacteria,1VF7W@1239|Firmicutes,24R5W@186801|Clostridia,36KXR@31979|Clostridiaceae	186801|Clostridia	C	NADH dehydrogenase	-	-	-	ko:K14089	-	-	-	-	ko00000	-	-	-	Complex1_30kDa
HKD1_k127_6421795_0	1499683.CCFF01000015_gene3378	3.727e-115	376.0	COG2270@1|root,COG2270@2|Bacteria,1TRTH@1239|Firmicutes,24AYI@186801|Clostridia,36GR3@31979|Clostridiaceae	186801|Clostridia	S	Major Facilitator	-	-	-	ko:K06902	ko04138,map04138	-	-	-	ko00000,ko00001,ko02000,ko04131	2.A.1.24,9.A.15.1	-	-	ATG22
HKD1_k127_6421795_1	997296.PB1_13054	2.154e-44	167.0	COG2323@1|root,COG2323@2|Bacteria,1TX6U@1239|Firmicutes,4HEB2@91061|Bacilli,1ZQ03@1386|Bacillus	91061|Bacilli	S	Protein of unknown function (DUF421)	-	-	-	-	-	-	-	-	-	-	-	-	DUF421
HKD1_k127_6421895_0	865861.AZSU01000006_gene1195	3.682e-149	481.0	COG0474@1|root,COG0474@2|Bacteria,1TPF5@1239|Firmicutes,247JN@186801|Clostridia,36DDM@31979|Clostridiaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	pacL	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase,Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD1_k127_642911_2	1195236.CTER_0262	8.695e-08	57.0	COG1879@1|root,COG1879@2|Bacteria,1UE0M@1239|Firmicutes,24C7Y@186801|Clostridia	186801|Clostridia	G	ABC-type sugar transport system, periplasmic	-	-	-	ko:K10439	ko02010,ko02030,map02010,map02030	M00212	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.2.1,3.A.1.2.13,3.A.1.2.19	-	-	Peripla_BP_4
HKD1_k127_642911_0	1195236.CTER_0381	7.208e-141	456.0	COG0673@1|root,COG0673@2|Bacteria,1TSWE@1239|Firmicutes,24CB6@186801|Clostridia,3WRKP@541000|Ruminococcaceae	186801|Clostridia	S	Oxidoreductase family, NAD-binding Rossmann fold	-	-	-	-	-	-	-	-	-	-	-	-	GFO_IDH_MocA,GFO_IDH_MocA_C
HKD1_k127_642911_1	588581.Cpap_2799	1.327e-91	302.0	COG1082@1|root,COG1082@2|Bacteria,1TPJT@1239|Firmicutes,24DB5@186801|Clostridia	186801|Clostridia	G	AP endonuclease family 2 C terminus	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2,AP_endonuc_2_N
HKD1_k127_6441259_0	509191.AEDB02000094_gene4306	1.39e-77	267.0	COG5523@1|root,COG5523@2|Bacteria,1V6FC@1239|Firmicutes,24JPX@186801|Clostridia,3WJR0@541000|Ruminococcaceae	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	DUF975
HKD1_k127_6461298_1	332101.JIBU02000051_gene3432	5.845e-60	209.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,36HSG@31979|Clostridiaceae	186801|Clostridia	C	Electron transfer flavoprotein domain	-	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD1_k127_6461298_0	332101.JIBU02000051_gene3433	3.111e-195	618.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36GQP@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidases, C-terminal domain	-	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_6461298_3	1395513.P343_09825	1.514e-12	79.0	2E9SM@1|root,333YT@2|Bacteria,1VNW8@1239|Firmicutes,4HS8V@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6461298_2	1395513.P343_09825	1.429e-14	85.0	2E9SM@1|root,333YT@2|Bacteria,1VNW8@1239|Firmicutes,4HS8V@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_647707_1	1347392.CCEZ01000004_gene744	1.386e-14	74.0	COG0640@1|root,COG0640@2|Bacteria,1VF14@1239|Firmicutes,24MW7@186801|Clostridia,36KF9@31979|Clostridiaceae	186801|Clostridia	K	regulatory protein, arsR	pagR	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5
HKD1_k127_647707_0	1120998.AUFC01000003_gene1485	5.021e-136	438.0	COG0446@1|root,COG0607@1|root,COG2210@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,COG2210@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia	186801|Clostridia	C	Pyridine nucleotide-disulphide oxidoreductase, dimerisation	cdr	-	-	-	-	-	-	-	-	-	-	-	DrsE_2,Pyr_redox_2,Pyr_redox_dim,Rhodanese,TusA
HKD1_k127_6478603_0	742733.HMPREF9469_01216	5.022e-218	682.0	COG3033@1|root,COG3033@2|Bacteria,1TRGV@1239|Firmicutes,248WC@186801|Clostridia,21Z1N@1506553|Lachnoclostridium	186801|Clostridia	E	Beta-eliminating lyase	tnaA	-	4.1.99.1	ko:K01667	ko00380,map00380	-	R00673	RC00209,RC00355	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD1_k127_6478603_1	1476973.JMMB01000007_gene1865	3.062e-61	213.0	COG0488@1|root,COG0488@2|Bacteria,1TSB8@1239|Firmicutes,248XT@186801|Clostridia,25QK3@186804|Peptostreptococcaceae	186801|Clostridia	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_6488067_0	1519439.JPJG01000091_gene628	6.283e-142	468.0	COG1529@1|root,COG1529@2|Bacteria,1TP7U@1239|Firmicutes,248BV@186801|Clostridia,2N87A@216572|Oscillospiraceae	186801|Clostridia	C	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_6488067_1	608534.GCWU000341_01773	1.351e-61	215.0	COG2080@1|root,COG2080@2|Bacteria,1V6HE@1239|Firmicutes,24FZI@186801|Clostridia,2PS8K@265975|Oribacterium	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	1.2.5.3	ko:K03518	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD1_k127_6488067_2	457570.Nther_2153	3.55e-33	135.0	COG1319@1|root,COG1319@2|Bacteria,1TQA5@1239|Firmicutes,248WI@186801|Clostridia	186801|Clostridia	C	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM	-	-	1.17.1.5	ko:K20445	ko00760,ko01120,map00760,map01120	-	R01720	RC00589	ko00000,ko00001,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_6511733_2	1120998.AUFC01000017_gene165	1.113e-51	190.0	COG4461@1|root,COG4461@2|Bacteria,1VDVF@1239|Firmicutes,24N0M@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4163)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3298,DUF4163
HKD1_k127_6511733_3	350688.Clos_0627	7.454e-44	169.0	COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,36WRU@31979|Clostridiaceae	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_6511733_4	1304880.JAGB01000001_gene346	9.619e-42	162.0	COG1388@1|root,COG1388@2|Bacteria,1V10C@1239|Firmicutes	1239|Firmicutes	M	PFAM LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_6511733_1	1410670.JHXF01000001_gene2650	3.252e-56	200.0	COG0328@1|root,COG0328@2|Bacteria,1V4A0@1239|Firmicutes,24FSS@186801|Clostridia,3WISH@541000|Ruminococcaceae	186801|Clostridia	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD1_k127_6511733_0	1120998.AUFC01000029_gene189	5.571e-120	397.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,3WDG2@538999|Clostridiales incertae sedis	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_6512885_3	556261.HMPREF0240_04357	7.323e-43	162.0	COG0558@1|root,COG0558@2|Bacteria,1V6PJ@1239|Firmicutes,24J7Y@186801|Clostridia,36FYW@31979|Clostridiaceae	186801|Clostridia	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD1_k127_6512885_1	445971.ANASTE_02041	3.804e-145	472.0	COG0621@1|root,COG0621@2|Bacteria,1TP2W@1239|Firmicutes,2487D@186801|Clostridia,25UQB@186806|Eubacteriaceae	186801|Clostridia	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD1_k127_6512885_0	1304284.L21TH_0686	7.863e-207	671.0	COG1674@1|root,COG1674@2|Bacteria,1TPJR@1239|Firmicutes,247KM@186801|Clostridia,36DDP@31979|Clostridiaceae	186801|Clostridia	D	Belongs to the FtsK SpoIIIE SftA family	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD1_k127_6512885_2	1304284.L21TH_0684	4.556e-86	289.0	COG0740@1|root,COG0740@2|Bacteria,1TPX2@1239|Firmicutes,249QX@186801|Clostridia,36E2N@31979|Clostridiaceae	186801|Clostridia	OU	Clp protease	tepA	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD1_k127_6528525_0	485916.Dtox_2849	1.788e-211	669.0	COG0671@1|root,COG0671@2|Bacteria,1USD9@1239|Firmicutes	1239|Firmicutes	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD1_k127_6528525_1	641112.ACOK01000055_gene3798	2.244e-13	70.0	COG0482@1|root,COG0482@2|Bacteria,1TPIZ@1239|Firmicutes,247YV@186801|Clostridia,3WGZU@541000|Ruminococcaceae	186801|Clostridia	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD1_k127_6535212_3	332101.JIBU02000016_gene2382	5.663e-19	87.0	COG1443@1|root,COG1443@2|Bacteria,1UJH0@1239|Firmicutes,25F2Q@186801|Clostridia,36UWM@31979|Clostridiaceae	186801|Clostridia	I	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6535212_2	1120746.CCNL01000017_gene2407	1.715e-45	169.0	COG0716@1|root,COG0716@2|Bacteria	2|Bacteria	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	Flavodoxin_4
HKD1_k127_6535212_0	476272.RUMHYD_01174	3.507e-88	300.0	COG0280@1|root,COG0280@2|Bacteria,1TRQU@1239|Firmicutes,24857@186801|Clostridia	186801|Clostridia	C	PFAM Phosphate acetyl butaryl transferase	-	-	2.3.1.19	ko:K00634	ko00650,ko01100,map00650,map01100	-	R01174	RC00004,RC02816	ko00000,ko00001,ko01000	-	-	-	PTA_PTB
HKD1_k127_6535212_1	1294142.CINTURNW_2577	1.789e-74	253.0	COG0163@1|root,COG0163@2|Bacteria,1V3JV@1239|Firmicutes,24HE5@186801|Clostridia,36GMJ@31979|Clostridiaceae	186801|Clostridia	H	Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3- polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN	ubiX	-	2.5.1.129	ko:K03186	ko00130,ko00627,ko00940,ko01100,ko01110,ko01120,ko01220,map00130,map00627,map00940,map01100,map01110,map01120,map01220	M00117	R01238,R02952,R03367,R04985,R04986,R11225	RC00391,RC00814,RC03392	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavoprotein
HKD1_k127_6541222_0	1304284.L21TH_0227	2.207e-150	487.0	COG0697@1|root,COG0697@2|Bacteria,1TP7K@1239|Firmicutes,248Q8@186801|Clostridia,36DVY@31979|Clostridiaceae	186801|Clostridia	EG	Spore germination protein	gerA	-	-	ko:K06310	-	-	-	-	ko00000	-	-	-	GerA
HKD1_k127_6541222_1	935948.KE386495_gene1611	3.603e-23	112.0	COG0531@1|root,COG0531@2|Bacteria,1TZQ6@1239|Firmicutes,24EQ1@186801|Clostridia,42G6B@68295|Thermoanaerobacterales	186801|Clostridia	E	PFAM spore germination	-	-	-	ko:K06296,ko:K06311	-	-	-	-	ko00000,ko02000	2.A.3.9.3,2.A.3.9.4	-	-	Spore_permease
HKD1_k127_6541222_2	858215.Thexy_0165	3.08e-07	53.0	28IEM@1|root,2Z8GN@2|Bacteria,1UB3Y@1239|Firmicutes,247YH@186801|Clostridia,42G3Y@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM spore germination B3 GerAC family protein	-	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD1_k127_6541382_1	697303.Thewi_2558	2.142e-21	98.0	2AUKD@1|root,31K93@2|Bacteria,1V6PK@1239|Firmicutes,24J91@186801|Clostridia,42GA7@68295|Thermoanaerobacterales	186801|Clostridia	S	PFAM Sporulation stage II protein R	spoIIR	-	-	ko:K06387	-	-	-	-	ko00000	-	-	-	Spore_II_R
HKD1_k127_6541382_0	1347392.CCEZ01000009_gene2315	1.113e-41	167.0	28IEM@1|root,2Z8GN@2|Bacteria,1UB3Y@1239|Firmicutes,247YH@186801|Clostridia,36DZ5@31979|Clostridiaceae	186801|Clostridia	S	Spore germination B3/ GerAC like, C-terminal	-	-	-	ko:K06297	-	-	-	-	ko00000	-	-	-	Spore_GerAC
HKD1_k127_6545803_0	1304284.L21TH_1332	2.022e-183	580.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD1_k127_6545803_2	1121289.JHVL01000003_gene2182	6.868e-37	146.0	COG0779@1|root,COG0779@2|Bacteria,1V6KT@1239|Firmicutes,24N1G@186801|Clostridia,36JKE@31979|Clostridiaceae	186801|Clostridia	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD1_k127_6545803_1	1121289.JHVL01000003_gene2181	4.886e-133	432.0	COG0195@1|root,COG0195@2|Bacteria,1TPB3@1239|Firmicutes,247W8@186801|Clostridia,36DXE@31979|Clostridiaceae	186801|Clostridia	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KH_5,NusA_N,S1
HKD1_k127_6545803_3	1128398.Curi_c15570	1.751e-30	122.0	COG2740@1|root,COG2740@2|Bacteria,1VEJS@1239|Firmicutes,24QSJ@186801|Clostridia,269QA@186813|unclassified Clostridiales	186801|Clostridia	K	Protein of unknown function (DUF448)	ylxR	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HKD1_k127_6545803_4	857293.CAAU_1449	1.637e-16	82.0	COG1358@1|root,COG1358@2|Bacteria,1VEYG@1239|Firmicutes,24QP3@186801|Clostridia,36MPB@31979|Clostridiaceae	186801|Clostridia	J	PFAM ribosomal protein L7Ae L30e S12e Gadd45	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L7Ae
HKD1_k127_6545803_5	1089553.Tph_c11310	5.163e-07	55.0	COG0532@1|root,COG0532@2|Bacteria,1TPAI@1239|Firmicutes,248SJ@186801|Clostridia,42EP2@68295|Thermoanaerobacterales	186801|Clostridia	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N
HKD1_k127_6546712_1	1128398.Curi_c08630	1.536e-51	198.0	COG0826@1|root,COG0826@2|Bacteria,1TQS1@1239|Firmicutes,24909@186801|Clostridia,267MR@186813|unclassified Clostridiales	186801|Clostridia	O	Collagenase	-	-	-	ko:K08303	ko05120,map05120	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3656,Peptidase_U32
HKD1_k127_6546712_0	1128398.Curi_c08640	9.758e-250	793.0	COG1193@1|root,COG1193@2|Bacteria,1TP5W@1239|Firmicutes,248YK@186801|Clostridia,267U7@186813|unclassified Clostridiales	186801|Clostridia	L	Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity	mutS2	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V,Smr
HKD1_k127_6546712_2	391625.PPSIR1_28991	3.61e-12	76.0	COG4552@1|root,COG4552@2|Bacteria,1NJ0B@1224|Proteobacteria,42XQI@68525|delta/epsilon subdivisions,2WTCP@28221|Deltaproteobacteria	28221|Deltaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_9
HKD1_k127_6548509_0	484770.UFO1_4658	8.655e-50	183.0	COG1757@1|root,COG1757@2|Bacteria,1TQ3B@1239|Firmicutes,4H474@909932|Negativicutes	909932|Negativicutes	C	Na H antiporter	nhaC	-	-	ko:K03315	-	-	-	-	ko00000,ko02000	2.A.35	-	-	Na_H_antiporter
HKD1_k127_6548509_1	994573.T472_0208585	3.765e-48	177.0	COG0491@1|root,COG0491@2|Bacteria,1TSU6@1239|Firmicutes,24DDT@186801|Clostridia,36FFX@31979|Clostridiaceae	186801|Clostridia	S	metallo-beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_6549721_1	1414720.CBYM010000024_gene2121	5.445e-89	314.0	COG2199@1|root,COG3706@2|Bacteria,1TQIK@1239|Firmicutes,249Y6@186801|Clostridia,36WDP@31979|Clostridiaceae	186801|Clostridia	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GGDEF,TPR_12,TPR_8
HKD1_k127_6549721_0	1304284.L21TH_0725	1.354e-131	426.0	COG0174@1|root,COG0174@2|Bacteria,1TNZA@1239|Firmicutes,2489S@186801|Clostridia,36DYK@31979|Clostridiaceae	186801|Clostridia	E	glutamine synthetase	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C
HKD1_k127_6550901_1	445973.CLOBAR_00599	6.991e-55	196.0	COG1959@1|root,COG1959@2|Bacteria,1V3QB@1239|Firmicutes,24JIV@186801|Clostridia,25RD2@186804|Peptostreptococcaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD1_k127_6550901_0	610130.Closa_2545	3.569e-121	393.0	COG1179@1|root,COG1179@2|Bacteria,1TQ7A@1239|Firmicutes,248RA@186801|Clostridia,21YZT@1506553|Lachnoclostridium	186801|Clostridia	H	PFAM UBA THIF-type NAD FAD binding protein	thiF	-	-	ko:K22132	-	-	-	-	ko00000,ko03016	-	-	-	ThiF
HKD1_k127_6550901_2	445972.ANACOL_00355	2.17e-09	58.0	COG2244@1|root,COG2244@2|Bacteria,1TR7A@1239|Firmicutes,24C7V@186801|Clostridia,3WGB1@541000|Ruminococcaceae	186801|Clostridia	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3,Polysacc_synt_C
HKD1_k127_6557628_1	1304284.L21TH_1260	2.569e-72	248.0	COG0503@1|root,COG0503@2|Bacteria,1V1BV@1239|Firmicutes,24HGX@186801|Clostridia,36HZI@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	Pribosyltran
HKD1_k127_6557628_0	1304284.L21TH_1259	1.125e-92	309.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,36EH5@31979|Clostridiaceae	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_6563698_0	1304284.L21TH_1027	2.102e-87	297.0	COG0168@1|root,COG0168@2|Bacteria,1TQ4S@1239|Firmicutes,247Q3@186801|Clostridia,36DPR@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein, TrkH family	ktrB	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
HKD1_k127_6578731_0	1408422.JHYF01000016_gene57	9.141e-104	357.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,36EVN@31979|Clostridiaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_6581365_2	1449050.JNLE01000003_gene3185	1.276e-49	179.0	COG0160@1|root,COG0160@2|Bacteria,1VS6F@1239|Firmicutes,24YI0@186801|Clostridia,36ED9@31979|Clostridiaceae	186801|Clostridia	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	2.6.1.19,2.6.1.22	ko:K00823,ko:K07250	ko00250,ko00280,ko00410,ko00640,ko00650,ko01100,ko01120,map00250,map00280,map00410,map00640,map00650,map01100,map01120	M00027	R00908,R01648,R04188	RC00006,RC00062,RC00160	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_6581365_1	1347086.CCBA010000023_gene2197	4.651e-55	197.0	COG0251@1|root,COG0251@2|Bacteria,1V6G4@1239|Firmicutes,4HHIF@91061|Bacilli,1ZGKI@1386|Bacillus	91061|Bacilli	J	endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP,YjgF_endoribonc
HKD1_k127_6581365_0	1120998.AUFC01000025_gene821	3.814e-212	670.0	COG1757@1|root,COG1757@2|Bacteria,1TP8A@1239|Firmicutes,247V4@186801|Clostridia	186801|Clostridia	C	Na H antiporter	nhaC	-	-	-	-	-	-	-	-	-	-	-	Na_H_antiporter
HKD1_k127_6585145_0	1304284.L21TH_0213	3.762e-97	332.0	COG1193@1|root,COG1193@2|Bacteria,1TSBW@1239|Firmicutes,24814@186801|Clostridia,36FV5@31979|Clostridiaceae	186801|Clostridia	L	ATPase domain of DNA mismatch repair MUTS family	-	-	-	ko:K07456	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_V
HKD1_k127_6585145_1	1304284.L21TH_0214	6.297e-88	302.0	2C3VR@1|root,2Z9AE@2|Bacteria,1UZNB@1239|Firmicutes,24D9F@186801|Clostridia,36FQA@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6585145_2	1304284.L21TH_0215	2.157e-11	64.0	COG1509@1|root,COG1509@2|Bacteria,1TQQZ@1239|Firmicutes,249JV@186801|Clostridia,36E9A@31979|Clostridiaceae	186801|Clostridia	E	lysine 2,3-aminomutase YodO family protein	ablA	-	5.4.3.2	ko:K01843	ko00310,map00310	-	R00461	RC00303	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,LAM_C,Radical_SAM
HKD1_k127_6587461_0	1304284.L21TH_1222	7.913e-74	258.0	COG2385@1|root,COG2385@2|Bacteria,1TQSI@1239|Firmicutes,249H0@186801|Clostridia,36EBP@31979|Clostridiaceae	186801|Clostridia	D	stage II sporulation protein D	spoIID	-	-	ko:K06381	-	-	-	-	ko00000	-	-	-	SpoIID
HKD1_k127_6587461_2	1304284.L21TH_1223	2.101e-29	126.0	COG0739@1|root,COG0739@2|Bacteria,1V96D@1239|Firmicutes,24AXE@186801|Clostridia,36FA4@31979|Clostridiaceae	186801|Clostridia	M	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD1_k127_6587461_1	293826.Amet_0364	1.617e-30	122.0	COG1609@1|root,COG1609@2|Bacteria,1VADF@1239|Firmicutes,24MXI@186801|Clostridia,36KQT@31979|Clostridiaceae	186801|Clostridia	K	Stage III sporulation protein D	spoIIID	-	-	ko:K06283	-	-	-	-	ko00000,ko03000	-	-	-	SpoIIID
HKD1_k127_6592461_0	318464.IO99_11750	2.336e-81	273.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_6592461_1	272562.CA_C3332	1.621e-35	136.0	COG1228@1|root,COG1228@2|Bacteria,1TPNQ@1239|Firmicutes,248UT@186801|Clostridia,36E56@31979|Clostridiaceae	186801|Clostridia	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD1_k127_6593113_5	742743.HMPREF9453_00605	1.709e-10	61.0	COG3958@1|root,COG3958@2|Bacteria,1V0K5@1239|Firmicutes,4H2N6@909932|Negativicutes	909932|Negativicutes	G	Transketolase, pyridine binding domain protein	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD1_k127_6593113_1	1304284.L21TH_2454	8.562e-107	352.0	COG3959@1|root,COG3959@2|Bacteria,1TT51@1239|Firmicutes,247IK@186801|Clostridia,36DP2@31979|Clostridiaceae	186801|Clostridia	G	Transketolase	-	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transketolase_N
HKD1_k127_6593113_0	941824.TCEL_01175	1.789e-107	352.0	COG0176@1|root,COG0176@2|Bacteria,1TP4Q@1239|Firmicutes,248KZ@186801|Clostridia,36EK7@31979|Clostridiaceae	186801|Clostridia	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD1_k127_6593113_2	1304284.L21TH_2452	1.197e-92	310.0	COG1922@1|root,COG1922@2|Bacteria,1V3QV@1239|Firmicutes,24AQ3@186801|Clostridia,36E8D@31979|Clostridiaceae	186801|Clostridia	M	Catalyzes the conversion of GlcNAc-PP-undecaprenol into ManNAc-GlcNAc-PP-undecaprenol, the first committed lipid intermediate in the de novo synthesis of teichoic acid	tagA	-	2.4.1.187	ko:K05946	ko05111,map05111	-	-	-	ko00000,ko00001,ko01000,ko01003	-	GT26	-	Glyco_tran_WecB,PS_pyruv_trans
HKD1_k127_6593113_3	1128398.Curi_c20780	1.652e-72	257.0	COG2327@1|root,COG2327@2|Bacteria,1TPTI@1239|Firmicutes,248QN@186801|Clostridia,2682P@186813|unclassified Clostridiales	186801|Clostridia	M	Polysaccharide pyruvyl transferase	csaB	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_4,Glycos_transf_1,PS_pyruv_trans
HKD1_k127_6593113_4	350688.Clos_2271	1.699e-66	237.0	2DBE5@1|root,2Z8QQ@2|Bacteria,1TPFD@1239|Firmicutes,24E93@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6593997_0	332101.JIBU02000019_gene2213	3.248e-126	416.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PrpR_N,Sigma54_activat
HKD1_k127_6612496_2	1347392.CCEZ01000049_gene1647	4.271e-30	119.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,36DSR@31979|Clostridiaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_6612496_1	1121289.JHVL01000013_gene1650	4.438e-196	619.0	COG0556@1|root,COG0556@2|Bacteria,1TPKB@1239|Firmicutes,247P7@186801|Clostridia,36DSR@31979|Clostridiaceae	186801|Clostridia	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD1_k127_6612496_0	1347392.CCEZ01000049_gene1646	5.86e-248	775.0	COG0178@1|root,COG0178@2|Bacteria,1TPIJ@1239|Firmicutes,2485F@186801|Clostridia,36E0I@31979|Clostridiaceae	186801|Clostridia	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD1_k127_6619513_0	1507.HMPREF0262_01439	8.668e-169	536.0	COG0370@1|root,COG0370@2|Bacteria,1TP7E@1239|Firmicutes,24885@186801|Clostridia,36DF0@31979|Clostridiaceae	186801|Clostridia	P	transporter of a GTP-driven Fe(2 ) uptake system	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoA,FeoB_C,FeoB_N,Gate
HKD1_k127_6624419_0	350688.Clos_2271	3.174e-99	339.0	2DBE5@1|root,2Z8QQ@2|Bacteria,1TPFD@1239|Firmicutes,24E93@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score 10.00	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_6626350_0	411489.CLOL250_01316	2.484e-64	229.0	COG2607@1|root,COG2607@2|Bacteria,1TQDJ@1239|Firmicutes,2483S@186801|Clostridia,36EJK@31979|Clostridiaceae	186801|Clostridia	S	ATPase (AAA superfamily)	-	-	-	ko:K06923	-	-	-	-	ko00000	-	-	-	DUF815
HKD1_k127_6626350_1	1304284.L21TH_2159	2.162e-60	214.0	COG1595@1|root,COG1595@2|Bacteria,1TS3M@1239|Firmicutes,24IW2@186801|Clostridia,36K9Y@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the sigma-70 factor family. ECF subfamily	algU	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD1_k127_6626350_2	509191.AEDB02000109_gene4961	1.756e-12	72.0	COG5662@1|root,COG5662@2|Bacteria,1VKS6@1239|Firmicutes,24VD1@186801|Clostridia,3WM8H@541000|Ruminococcaceae	186801|Clostridia	K	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD1_k127_6644703_0	293826.Amet_3206	3.683e-115	379.0	COG1304@1|root,COG1304@2|Bacteria,1TPC4@1239|Firmicutes,249TX@186801|Clostridia,36F63@31979|Clostridiaceae	186801|Clostridia	C	FMN-dependent	lldD	-	-	-	-	-	-	-	-	-	-	-	FMN_dh
HKD1_k127_6647056_0	931276.Cspa_c28610	3.316e-260	807.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
HKD1_k127_6647322_0	642492.Clole_2568	5.637e-83	277.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia	186801|Clostridia	S	Abc transporter	yfmM	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_Xtn
HKD1_k127_6656375_0	1220589.CD32_03550	1.724e-18	93.0	COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes,4HH96@91061|Bacilli,3IVP1@400634|Lysinibacillus	91061|Bacilli	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_6666181_1	199310.c4545	3.736e-23	102.0	COG2972@1|root,COG4936@1|root,COG2972@2|Bacteria,COG4936@2|Bacteria,1MXVQ@1224|Proteobacteria,1RQDA@1236|Gammaproteobacteria,3XQG8@561|Escherichia	1236|Gammaproteobacteria	T	Sensory domain found in PocR	-	-	2.7.13.3	ko:K02478,ko:K08082	ko02020,map02020	M00493	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,His_kinase,PocR
HKD1_k127_6666181_0	411469.EUBHAL_00528	5.688e-86	296.0	COG2207@1|root,COG4753@1|root,COG2207@2|Bacteria,COG4753@2|Bacteria,1TSKR@1239|Firmicutes,24AFC@186801|Clostridia,25V1K@186806|Eubacteriaceae	186801|Clostridia	K	Psort location Cytoplasmic, score	-	-	-	ko:K07720	ko02020,map02020	M00519	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_18,HTH_AraC,Response_reg
HKD1_k127_6675815_1	941824.TCEL_01719	3.464e-10	63.0	COG0465@1|root,COG0465@2|Bacteria,1U2AD@1239|Firmicutes,24A06@186801|Clostridia,36FVV@31979|Clostridiaceae	186801|Clostridia	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH1	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD1_k127_6675815_0	1304284.L21TH_0269	5.56e-115	379.0	COG1609@1|root,COG1609@2|Bacteria,1TQ7K@1239|Firmicutes,247M2@186801|Clostridia,36F5I@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator, LacI family	ccpA	-	-	ko:K02529	-	-	-	-	ko00000,ko03000	-	-	-	LacI,Peripla_BP_3
HKD1_k127_6691759_0	1262449.CP6013_0891	5.175e-157	502.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_8,PAS_9,PTS-HPr,Sigma54_activat
HKD1_k127_6691759_1	1321778.HMPREF1982_00640	4.219e-102	338.0	COG0563@1|root,COG0563@2|Bacteria,1TP27@1239|Firmicutes,247YN@186801|Clostridia,268PU@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	iHN637.CLJU_RS20110	ADK,ADK_lid
HKD1_k127_6694848_0	1347392.CCEZ01000018_gene1115	3.334e-122	403.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,25100@186801|Clostridia,36UHR@31979|Clostridiaceae	186801|Clostridia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_6699003_0	1128398.Curi_c16270	6.757e-106	359.0	COG1196@1|root,COG1196@2|Bacteria,1TPJV@1239|Firmicutes,249F4@186801|Clostridia,267UY@186813|unclassified Clostridiales	186801|Clostridia	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N,SMC_hinge
HKD1_k127_6699003_1	1111134.HMPREF1253_1508	2.372e-84	289.0	COG1243@1|root,COG1243@2|Bacteria,1TS1F@1239|Firmicutes,248YV@186801|Clostridia,22FY3@1570339|Peptoniphilaceae	186801|Clostridia	BK	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer4_12,Fer4_14,Radical_SAM,Radical_SAM_C
HKD1_k127_6726968_1	768704.Desmer_1178	4.406e-06	51.0	COG1418@1|root,COG2068@1|root,COG1418@2|Bacteria,COG2068@2|Bacteria,1UY6E@1239|Firmicutes,249PV@186801|Clostridia,260Y2@186807|Peptococcaceae	186801|Clostridia	S	PFAM HD domain	-	-	-	-	-	-	-	-	-	-	-	-	HD,NTP_transf_3
HKD1_k127_6726968_0	748727.CLJU_c17950	6.23e-167	530.0	COG0303@1|root,COG0303@2|Bacteria,1TP7F@1239|Firmicutes,247TZ@186801|Clostridia,36DBJ@31979|Clostridiaceae	186801|Clostridia	H	molybdopterin binding domain	moeA2	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD1_k127_6742006_1	1121289.JHVL01000002_gene2412	3.274e-20	90.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,36DQF@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_6742006_0	1304284.L21TH_2122	1.982e-127	413.0	COG1032@1|root,COG1032@2|Bacteria,1TR2C@1239|Firmicutes,248HM@186801|Clostridia,36DQF@31979|Clostridiaceae	186801|Clostridia	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_6745607_6	1031288.AXAA01000018_gene39	5.091e-37	142.0	COG2094@1|root,COG2094@2|Bacteria,1V1E6@1239|Firmicutes,24FRV@186801|Clostridia,36I75@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the DNA glycosylase MPG family	-	-	3.2.2.21	ko:K03652	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Pur_DNA_glyco
HKD1_k127_6745607_5	1415775.U729_2527	1.497e-39	151.0	COG1846@1|root,COG1846@2|Bacteria,1V6MI@1239|Firmicutes,25CPT@186801|Clostridia,36WYW@31979|Clostridiaceae	186801|Clostridia	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	MarR
HKD1_k127_6745607_4	642492.Clole_3267	2.063e-63	228.0	COG1307@1|root,COG1307@2|Bacteria,1TRM7@1239|Firmicutes,247ST@186801|Clostridia	186801|Clostridia	T	EDD domain protein, DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_6745607_0	1304284.L21TH_0746	0.0	1023.0	COG0542@1|root,COG0542@2|Bacteria,1TPMU@1239|Firmicutes,2486F@186801|Clostridia,36F8B@31979|Clostridiaceae	186801|Clostridia	O	Negative regulator of genetic competence clpC mecB	-	-	-	ko:K03697	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
HKD1_k127_6745607_1	1304284.L21TH_1000	1.762e-110	364.0	COG0329@1|root,COG0329@2|Bacteria,1TPCK@1239|Firmicutes,247T5@186801|Clostridia,36DMX@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD1_k127_6745607_3	864565.HMPREF0379_1751	5.911e-79	269.0	COG0289@1|root,COG0289@2|Bacteria,1TR9D@1239|Firmicutes,248FY@186801|Clostridia	186801|Clostridia	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS17035	DapB_C,DapB_N
HKD1_k127_6745607_2	580327.Tthe_1058	1.969e-95	317.0	COG2171@1|root,COG2171@2|Bacteria,1TQUJ@1239|Firmicutes,248RU@186801|Clostridia,42EPY@68295|Thermoanaerobacterales	186801|Clostridia	E	Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate	dapH	-	2.3.1.117,2.3.1.89	ko:K00674,ko:K05822	ko00300,ko01100,ko01110,ko01120,ko01230,map00300,map01100,map01110,map01120,map01230	M00016,M00525	R04364,R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	DapH_N,Hexapep
HKD1_k127_6751710_1	445973.CLOBAR_01555	1.35e-37	143.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,25QIG@186804|Peptostreptococcaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_6751710_0	1128398.Curi_c15660	1.04e-61	221.0	COG4589@1|root,COG4589@2|Bacteria,1TT0Q@1239|Firmicutes,25HJP@186801|Clostridia,26CTH@186813|unclassified Clostridiales	186801|Clostridia	S	Cytidylyltransferase family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD1_k127_6751710_2	875454.BAEW01000001_gene223	9.045e-37	144.0	COG0750@1|root,COG0750@2|Bacteria,1TPMC@1239|Firmicutes,247MT@186801|Clostridia,22G61@1570339|Peptoniphilaceae	186801|Clostridia	M	metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD1_k127_6755201_0	180332.JTGN01000010_gene4537	1.608e-84	297.0	COG2246@1|root,COG4485@1|root,COG2246@2|Bacteria,COG4485@2|Bacteria,1TRR1@1239|Firmicutes,24BHM@186801|Clostridia	186801|Clostridia	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	YfhO
HKD1_k127_6759312_1	1540257.JQMW01000010_gene1323	1.767e-78	265.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,36EQA@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD1_k127_6759312_0	86416.Clopa_4244	3.639e-184	583.0	COG0303@1|root,COG1910@1|root,COG0303@2|Bacteria,COG1910@2|Bacteria,1TRH3@1239|Firmicutes,24ATZ@186801|Clostridia,36GB8@31979|Clostridiaceae	186801|Clostridia	P	DNA binding domain, excisionase family	-	-	2.10.1.1	ko:K03750,ko:K07219	ko00790,ko01100,map00790,map01100	-	R09735	RC03462	ko00000,ko00001,ko01000	-	-	-	MoCF_biosynth,MoeA_C,MoeA_N,PBP_like
HKD1_k127_6759969_1	1191523.MROS_0483	5.622e-08	61.0	COG1538@1|root,COG1538@2|Bacteria	2|Bacteria	MU	efflux transmembrane transporter activity	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD1_k127_6759969_0	1121324.CLIT_10c04710	2.293e-09	63.0	COG4399@1|root,COG4399@2|Bacteria,1V3CY@1239|Firmicutes,25JN5@186801|Clostridia,25SZU@186804|Peptostreptococcaceae	186801|Clostridia	S	Protein of unknown function (DUF445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD1_k127_6765608_0	555088.DealDRAFT_1252	9.01e-171	547.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247Q9@186801|Clostridia	186801|Clostridia	S	Abc transporter	yfmR	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_6765608_2	1304284.L21TH_1472	1.012e-65	237.0	COG5401@1|root,COG5401@2|Bacteria,1TPQD@1239|Firmicutes,248VN@186801|Clostridia,36F16@31979|Clostridiaceae	186801|Clostridia	S	Sporulation and spore germination	-	-	-	ko:K06298	-	-	-	-	ko00000	-	-	-	Germane
HKD1_k127_6765608_1	1304284.L21TH_2496	8.701e-139	448.0	COG0715@1|root,COG0715@2|Bacteria,1TQN5@1239|Firmicutes,248IG@186801|Clostridia,36ENM@31979|Clostridiaceae	186801|Clostridia	P	ABC-type nitrate sulfonate bicarbonate transport	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,NMT1_2
HKD1_k127_6765608_3	658086.HMPREF0994_06065	9.461e-11	62.0	COG0306@1|root,COG0306@2|Bacteria,1TQ3D@1239|Firmicutes,247ZC@186801|Clostridia,27RMT@186928|unclassified Lachnospiraceae	186801|Clostridia	U	Phosphate transporter family	pit	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD1_k127_6766700_1	641107.CDLVIII_3996	8.577e-98	321.0	COG1620@1|root,COG1620@2|Bacteria,1TQNM@1239|Firmicutes,2482V@186801|Clostridia,36DQ7@31979|Clostridiaceae	186801|Clostridia	C	L-lactate permease	lctP	-	-	ko:K03303	-	-	-	-	ko00000,ko02000	2.A.14	-	-	Lactate_perm
HKD1_k127_6766700_0	1196322.A370_03088	2.456e-112	363.0	COG0277@1|root,COG0277@2|Bacteria,1TPBC@1239|Firmicutes,24A99@186801|Clostridia,36DRC@31979|Clostridiaceae	186801|Clostridia	C	FAD linked oxidase domain protein	glcD	-	1.1.3.15	ko:K00104	ko00630,ko01100,ko01110,ko01120,ko01130,map00630,map01100,map01110,map01120,map01130	-	R00475	RC00042	ko00000,ko00001,ko01000	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD1_k127_6792633_1	1304284.L21TH_2544	3.601e-285	888.0	COG0445@1|root,COG0445@2|Bacteria,1TQ4B@1239|Firmicutes,247U2@186801|Clostridia,36E85@31979|Clostridiaceae	186801|Clostridia	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD1_k127_6792633_6	1347392.CCEZ01000010_gene2396	1.327e-76	263.0	COG0357@1|root,COG0357@2|Bacteria,1TPBT@1239|Firmicutes,247WM@186801|Clostridia,36EMZ@31979|Clostridiaceae	186801|Clostridia	J	Specifically methylates the N7 position of a guanine in 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD1_k127_6792633_5	1304284.L21TH_2542	3.494e-84	286.0	COG1475@1|root,COG1475@2|Bacteria,1TP0I@1239|Firmicutes,2488X@186801|Clostridia,36DCH@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	noc	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_6792633_4	1304284.L21TH_2541	1.831e-110	362.0	COG1192@1|root,COG1192@2|Bacteria,1TP8S@1239|Firmicutes,2488C@186801|Clostridia,36E15@31979|Clostridiaceae	186801|Clostridia	D	sporulation initiation inhibitor protein Soj	soj	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_6792633_7	1391647.AVSV01000014_gene442	1.66e-76	265.0	COG1475@1|root,COG1475@2|Bacteria,1TQ2B@1239|Firmicutes,249VV@186801|Clostridia,36DTS@31979|Clostridiaceae	186801|Clostridia	K	Belongs to the ParB family	spo0J	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD1_k127_6792633_8	865861.AZSU01000006_gene1308	2.157e-55	198.0	COG1905@1|root,COG1905@2|Bacteria,1V737@1239|Firmicutes,24HFB@186801|Clostridia,36IZJ@31979|Clostridiaceae	186801|Clostridia	C	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit	nuoE	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00334,ko:K18330,ko:K22340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD1_k127_6792633_9	1121289.JHVL01000043_gene1095	1.726e-46	169.0	COG3411@1|root,COG3411@2|Bacteria,1V6DT@1239|Firmicutes,24M31@186801|Clostridia,36JIG@31979|Clostridiaceae	186801|Clostridia	C	Ferredoxin	-	-	1.12.1.3	ko:K17992	-	-	-	-	ko00000,ko01000	-	-	-	2Fe-2S_thioredx
HKD1_k127_6792633_0	1232453.BAIF02000100_gene3623	3.166e-289	897.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,268CT@186813|unclassified Clostridiales	186801|Clostridia	C	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region	hymB	-	1.12.1.3,1.17.1.11,1.6.5.3	ko:K00335,ko:K18331,ko:K22339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD1_k127_6792633_2	1304284.L21TH_2535	5.673e-258	807.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,36DJB@31979|Clostridiaceae	186801|Clostridia	C	iron hydrogenase, small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,NADH-G_4Fe-4S_3
HKD1_k127_6792633_3	1301100.HG529340_gene2418	5.197e-174	553.0	COG0044@1|root,COG0044@2|Bacteria,1TPQM@1239|Firmicutes,247V2@186801|Clostridia,36ETY@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD1_k127_6806585_1	203119.Cthe_2268	9.566e-102	332.0	COG1156@1|root,COG1156@2|Bacteria,1VSU1@1239|Firmicutes,2496H@186801|Clostridia,3WG8C@541000|Ruminococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit	atpB	-	-	ko:K02118	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_6806585_2	500633.CLOHIR_00883	1.506e-95	317.0	COG1394@1|root,COG1394@2|Bacteria,1TQ1Y@1239|Firmicutes,247TC@186801|Clostridia,25T89@186804|Peptostreptococcaceae	186801|Clostridia	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpD	-	-	ko:K02120	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_D
HKD1_k127_6806585_0	1487921.DP68_04435	3.427e-118	389.0	COG2070@1|root,COG2070@2|Bacteria,1TPX1@1239|Firmicutes,247YZ@186801|Clostridia,36E43@31979|Clostridiaceae	186801|Clostridia	S	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD1_k127_6806585_3	1291050.JAGE01000001_gene1896	2.585e-20	92.0	COG0591@1|root,COG0591@2|Bacteria,1TPVE@1239|Firmicutes,248NQ@186801|Clostridia,3WGAA@541000|Ruminococcaceae	186801|Clostridia	E	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family	putP	-	-	ko:K11928	-	-	-	-	ko00000,ko02000	2.A.21.2	-	-	SSF
HKD1_k127_6809389_1	411902.CLOBOL_01872	7.842e-173	546.0	COG1978@1|root,COG1978@2|Bacteria,1TPAB@1239|Firmicutes,2487X@186801|Clostridia,21XVE@1506553|Lachnoclostridium	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	grdB	-	1.21.4.2	ko:K10672	-	-	-	-	ko00000,ko01000	-	-	-	GRDB
HKD1_k127_6809389_0	1347392.CCEZ01000018_gene1136	2.829e-201	630.0	28HF7@1|root,2Z7RC@2|Bacteria,1TQET@1239|Firmicutes,249YW@186801|Clostridia,36FG0@31979|Clostridiaceae	186801|Clostridia	C	PFAM Glycine sarcosine betaine reductase complex, protein B, alpha and beta subunits	grdE	-	1.21.4.2	ko:K10671	-	-	-	-	ko00000,ko01000	-	-	-	Gly_reductase
HKD1_k127_6832001_0	394503.Ccel_1022	3.142e-240	749.0	COG2271@1|root,COG2271@2|Bacteria,1TS8G@1239|Firmicutes,24F9J@186801|Clostridia,36GAM@31979|Clostridiaceae	186801|Clostridia	G	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08170	-	M00702	-	-	ko00000,ko00002,ko01504,ko02000	2.A.1.3.23,2.A.1.3.59	-	-	MFS_1
HKD1_k127_6832001_1	536227.CcarbDRAFT_2051	3.778e-230	715.0	COG1473@1|root,COG1473@2|Bacteria,1TPD7@1239|Firmicutes,248AH@186801|Clostridia,36DRG@31979|Clostridiaceae	186801|Clostridia	E	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_6832001_3	1232452.BAIB02000016_gene2315	1.937e-32	132.0	COG0526@1|root,COG0526@2|Bacteria,1VAPY@1239|Firmicutes,25B5Z@186801|Clostridia	186801|Clostridia	CO	PFAM alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
HKD1_k127_6832001_2	1304284.L21TH_0232	1.846e-66	235.0	COG1947@1|root,COG1947@2|Bacteria,1TPXV@1239|Firmicutes,24898@186801|Clostridia,36DM7@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_6837478_5	1304284.L21TH_1549	1.479e-49	178.0	COG2183@1|root,COG2183@2|Bacteria,1TPFE@1239|Firmicutes,248P0@186801|Clostridia,36DQ1@31979|Clostridiaceae	186801|Clostridia	K	domain protein	yhgF	-	-	ko:K06959	-	-	-	-	ko00000	-	-	-	HHH_3,S1,Tex_N,Tex_YqgF
HKD1_k127_6837478_6	941824.TCEL_01301	7.926e-40	156.0	COG0546@1|root,COG0546@2|Bacteria,1TPPZ@1239|Firmicutes,24GK6@186801|Clostridia,36IAM@31979|Clostridiaceae	186801|Clostridia	F	IA, variant 1	ppaX	-	3.1.3.18,3.6.1.1	ko:K01091,ko:K06019	ko00190,ko00630,ko01100,ko01110,ko01130,map00190,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD1_k127_6837478_4	1121129.KB903359_gene2601	4.792e-111	366.0	COG1024@1|root,COG1024@2|Bacteria,4NFEM@976|Bacteroidetes,2FWH6@200643|Bacteroidia,22ZY4@171551|Porphyromonadaceae	976|Bacteroidetes	I	Belongs to the enoyl-CoA hydratase isomerase family	crt	-	4.2.1.155,4.2.1.17,5.3.3.18	ko:K01692,ko:K01715,ko:K15866,ko:K20036	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00920,ko00930,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00920,map00930,map01100,map01110,map01120,map01130,map01200,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093,R09837,R09839,R10936	RC00004,RC00326,RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115,RC02689,RC03003,RC03306,RC03307	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD1_k127_6837478_1	1235835.C814_03406	2.761e-192	605.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,3WI1F@541000|Ruminococcaceae	186801|Clostridia	C	Acyl-CoA dehydrogenase, C-terminal domain	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_6837478_3	1235835.C814_03407	1.69e-130	420.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,247K9@186801|Clostridia,3WH8V@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	etfB	-	1.3.1.108	ko:K03521,ko:K22431	-	-	-	-	ko00000,ko01000	-	-	-	ETF
HKD1_k127_6837478_2	445972.ANACOL_04416	3.622e-138	447.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,247NF@186801|Clostridia,3WGKC@541000|Ruminococcaceae	186801|Clostridia	C	Electron transfer flavoprotein FAD-binding domain	etfA	-	1.3.1.108	ko:K03522,ko:K22432	-	-	-	-	ko00000,ko01000,ko04147	-	-	-	ETF,ETF_alpha
HKD1_k127_6837478_0	702450.CUW_0310	1.866e-268	838.0	COG0449@1|root,COG0449@2|Bacteria,1TPGU@1239|Firmicutes,3VP3E@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD1_k127_683970_0	865861.AZSU01000005_gene832	8.668e-32	138.0	COG0419@1|root,COG0419@2|Bacteria,1UI2P@1239|Firmicutes,25EBC@186801|Clostridia,36F55@31979|Clostridiaceae	186801|Clostridia	L	AAA domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_23,AAA_27
HKD1_k127_683970_1	865861.AZSU01000005_gene833	1.206e-26	118.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,36FXK@31979|Clostridiaceae	186801|Clostridia	L	DNA repair exonuclease	mppE	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
HKD1_k127_6851716_0	536233.CLO_3152	3.32e-78	266.0	COG1309@1|root,COG1309@2|Bacteria,1V9BD@1239|Firmicutes,24G2B@186801|Clostridia,36IJG@31979|Clostridiaceae	186801|Clostridia	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_6862748_0	1449050.JNLE01000003_gene1880	1.513e-195	615.0	COG2060@1|root,COG2060@2|Bacteria,1TPDF@1239|Firmicutes,24868@186801|Clostridia,36DPN@31979|Clostridiaceae	186801|Clostridia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD1_k127_6862748_1	1469948.JPNB01000002_gene3914	7.261e-26	108.0	COG2216@1|root,COG2216@2|Bacteria,1TPV5@1239|Firmicutes,24835@186801|Clostridia,36E98@31979|Clostridiaceae	186801|Clostridia	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD1_k127_6883669_2	272562.CA_C1778	8.506e-56	200.0	COG1335@1|root,COG1335@2|Bacteria,1TSTB@1239|Firmicutes,24BCT@186801|Clostridia,36IKX@31979|Clostridiaceae	186801|Clostridia	Q	Isochorismatase family	PncA	-	3.5.1.19	ko:K08281	ko00760,ko01100,map00760,map01100	-	R01268	RC00100	ko00000,ko00001,ko01000	-	-	-	Isochorismatase
HKD1_k127_6883669_0	1121289.JHVL01000002_gene2427	3.812e-140	453.0	COG1142@1|root,COG2878@1|root,COG1142@2|Bacteria,COG2878@2|Bacteria,1TQGD@1239|Firmicutes,24904@186801|Clostridia,36FC4@31979|Clostridiaceae	186801|Clostridia	C	electron transport complex, RnfABCDGE type, B subunit	rnfB	-	-	ko:K03616	-	-	-	-	ko00000	-	-	-	FeS,Fer4,Fer4_13,Fer4_4,Fer4_9
HKD1_k127_6883669_1	1121289.JHVL01000002_gene2428	1.781e-71	245.0	COG4657@1|root,COG4657@2|Bacteria,1TS06@1239|Firmicutes,247UE@186801|Clostridia,36ESS@31979|Clostridiaceae	186801|Clostridia	C	Part of a membrane complex involved in electron transport	rnfA	-	-	ko:K03617	-	-	-	-	ko00000	-	-	-	Rnf-Nqr
HKD1_k127_68925_0	1031288.AXAA01000015_gene297	7.967e-130	434.0	COG0493@1|root,COG3383@1|root,COG0493@2|Bacteria,COG3383@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36FQY@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase	-	-	1.17.1.9	ko:K00123	ko00630,ko00680,ko01100,ko01120,ko01200,map00630,map00680,map01100,map01120,map01200	-	R00519	RC02796	ko00000,ko00001,ko01000	-	-	-	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_20,Fer4_6,Fer4_9,Molybdop_Fe4S4,Molybdopterin,Pyr_redox_2,Pyr_redox_3
HKD1_k127_6901362_2	545697.HMPREF0216_03423	1.731e-15	79.0	COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,36MRK@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
HKD1_k127_6901362_0	935836.JAEL01000017_gene793	8.83e-57	201.0	COG2606@1|root,COG2606@2|Bacteria,1V6JF@1239|Firmicutes,4HHFK@91061|Bacilli,1ZGGN@1386|Bacillus	91061|Bacilli	S	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily	ebsC	-	-	ko:K03976	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	tRNA_edit
HKD1_k127_6901362_1	1304284.L21TH_2404	1.358e-41	155.0	COG1136@1|root,COG1136@2|Bacteria,1TQC9@1239|Firmicutes,248Z6@186801|Clostridia,36EK4@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_6917234_1	1028307.EAE_04570	3.723e-05	46.0	COG1951@1|root,COG1951@2|Bacteria,1MW8J@1224|Proteobacteria,1RPUD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	C	Tartrate	ttdA	GO:0008150,GO:0008152,GO:1901275	4.2.1.32	ko:K03779	ko00630,map00630	-	R00339	RC01382	ko00000,ko00001,ko01000	-	-	iLF82_1304.LF82_2330	Fumerase
HKD1_k127_6917234_0	1552123.EP57_06855	7.712e-35	143.0	COG0345@1|root,COG0345@2|Bacteria,1UZ3D@1239|Firmicutes,4HCJ6@91061|Bacilli,26J85@186820|Listeriaceae	91061|Bacilli	E	Catalyzes the formation of L-proline from pyrroline-5-carboxylate	proG	-	1.5.1.2	ko:K00286,ko:K02239	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015,M00429	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000,ko02044	-	-	-	F420_oxidored,P5CR_dimer
HKD1_k127_692252_0	865861.AZSU01000003_gene1761	1.671e-131	428.0	COG4100@1|root,COG4100@2|Bacteria,1TQ88@1239|Firmicutes,247Y4@186801|Clostridia,36E3Z@31979|Clostridiaceae	186801|Clostridia	P	resistance protein	ynbB	-	-	-	-	-	-	-	-	-	-	-	Met_gamma_lyase
HKD1_k127_692252_2	394503.Ccel_1694	3.409e-22	98.0	COG1923@1|root,COG1923@2|Bacteria,1VEGI@1239|Firmicutes,24QIM@186801|Clostridia,36KQP@31979|Clostridiaceae	186801|Clostridia	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD1_k127_692252_1	1347392.CCEZ01000043_gene394	5.9e-103	343.0	COG0324@1|root,COG0324@2|Bacteria,1TPSC@1239|Firmicutes,248HB@186801|Clostridia,36DRA@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD1_k127_692252_3	1121289.JHVL01000027_gene226	6.459e-13	68.0	COG0323@1|root,COG0323@2|Bacteria,1TPGK@1239|Firmicutes,24902@186801|Clostridia,36EVN@31979|Clostridiaceae	186801|Clostridia	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD1_k127_6937298_0	1120998.AUFC01000008_gene1079	5.642e-173	550.0	COG1217@1|root,COG1217@2|Bacteria,1TQ5Y@1239|Firmicutes,248EB@186801|Clostridia,3WCFM@538999|Clostridiales incertae sedis	186801|Clostridia	T	Elongation factor G C-terminus	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2
HKD1_k127_6937298_2	748727.CLJU_c23480	6.496e-69	237.0	COG1854@1|root,COG1854@2|Bacteria,1V1CH@1239|Firmicutes,24G3R@186801|Clostridia,36I3G@31979|Clostridiaceae	186801|Clostridia	H	Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD)	luxS	-	4.4.1.21	ko:K07173	ko00270,ko01100,ko01230,ko02024,ko02026,ko05111,map00270,map01100,map01230,map02024,map02026,map05111	M00609	R01291	RC00069,RC01929	ko00000,ko00001,ko00002,ko01000	-	-	-	LuxS
HKD1_k127_6937298_1	1123009.AUID01000004_gene1521	3.619e-160	518.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,268BV@186813|unclassified Clostridiales	186801|Clostridia	KT	Bacterial regulatory protein, Fis family	-	-	-	ko:K06714	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_9,Sigma54_activat
HKD1_k127_6946222_0	635013.TherJR_0922	7.442e-93	313.0	COG0661@1|root,COG0661@2|Bacteria,1TPIV@1239|Firmicutes,2494Y@186801|Clostridia,2615S@186807|Peptococcaceae	186801|Clostridia	S	pfam abc1	-	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1,APH,RIO1,WaaY
HKD1_k127_6946222_1	865861.AZSU01000002_gene3109	0.0003772	48.0	COG0457@1|root,COG0457@2|Bacteria,1UJ4B@1239|Firmicutes,25EVP@186801|Clostridia,36JRU@31979|Clostridiaceae	186801|Clostridia	S	Copper amine oxidase N-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
HKD1_k127_6951160_5	1304284.L21TH_1075	2.068e-26	113.0	COG0420@1|root,COG0420@2|Bacteria,1TWMI@1239|Firmicutes,24BN3@186801|Clostridia,36FXK@31979|Clostridiaceae	186801|Clostridia	L	DNA repair exonuclease	mppE	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,Metallophos_2
HKD1_k127_6951160_3	1280692.AUJL01000001_gene206	1.745e-44	170.0	COG0664@1|root,COG0664@2|Bacteria,1TSP9@1239|Firmicutes,24FRD@186801|Clostridia,36I5N@31979|Clostridiaceae	186801|Clostridia	K	cyclic nucleotide-binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD1_k127_6951160_1	398512.JQKC01000012_gene258	1.258e-99	332.0	COG1149@1|root,COG1149@2|Bacteria,1VUEG@1239|Firmicutes,2503A@186801|Clostridia,3WSJM@541000|Ruminococcaceae	186801|Clostridia	C	PFAM 4Fe-4S	-	-	-	-	-	-	-	-	-	-	-	-	Fer4,Fer4_21,Fer4_6
HKD1_k127_6951160_2	536227.CcarbDRAFT_3623	4.749e-99	328.0	COG0101@1|root,COG0101@2|Bacteria,1TQUY@1239|Firmicutes,248GJ@186801|Clostridia,36F3W@31979|Clostridiaceae	186801|Clostridia	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA1	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD1_k127_6951160_0	469618.FVAG_01375	1.576e-103	342.0	COG1101@1|root,COG1101@2|Bacteria,379V6@32066|Fusobacteria	32066|Fusobacteria	S	ATPases associated with a variety of cellular activities	-	-	-	ko:K05833	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_tran
HKD1_k127_6951160_4	350688.Clos_2703	4.877e-43	160.0	COG4120@1|root,COG4120@2|Bacteria,1TPDJ@1239|Firmicutes,249P1@186801|Clostridia,36EMV@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K05832	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	BPD_transp_2
HKD1_k127_6969611_0	871963.Desdi_0104	1.468e-167	535.0	COG0786@1|root,COG0786@2|Bacteria,1TQA4@1239|Firmicutes,247WX@186801|Clostridia	186801|Clostridia	P	Catalyzes the sodium-dependent transport of glutamate	-	-	-	ko:K03312	-	-	-	-	ko00000,ko02000	2.A.27	-	-	Glt_symporter
HKD1_k127_6969611_1	748727.CLJU_c24190	1.094e-29	119.0	COG0493@1|root,COG0493@2|Bacteria,1TQ1A@1239|Firmicutes,248EK@186801|Clostridia,36E1P@31979|Clostridiaceae	186801|Clostridia	C	glutamate synthase (NADPH), homotetrameric	-	-	1.4.1.13,1.4.1.14	ko:K00266	ko00250,ko00910,ko01100,ko01110,ko01120,ko01130,ko01230,map00250,map00910,map01100,map01110,map01120,map01130,map01230	-	R00093,R00114,R00248	RC00006,RC00010,RC02799	ko00000,ko00001,ko01000	-	-	-	Fer4_20,Pyr_redox_2,Pyr_redox_3
HKD1_k127_6973198_1	1449126.JQKL01000001_gene1497	7.965e-75	256.0	COG1974@1|root,COG1974@2|Bacteria,1TQ3H@1239|Firmicutes,24AXJ@186801|Clostridia,267II@186813|unclassified Clostridiales	186801|Clostridia	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD1_k127_6973198_2	865861.AZSU01000003_gene1759	3.594e-13	73.0	COG1388@1|root,COG1388@2|Bacteria,1VK5T@1239|Firmicutes,259Q3@186801|Clostridia,36P3U@31979|Clostridiaceae	186801|Clostridia	M	Lysin motif	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_6973198_0	1304284.L21TH_0178	3.892e-115	379.0	COG4974@1|root,COG4974@2|Bacteria,1TQRG@1239|Firmicutes,247QQ@186801|Clostridia,36EKH@31979|Clostridiaceae	186801|Clostridia	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K03733,ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD1_k127_699137_0	868595.Desca_0311	1.347e-61	216.0	COG1785@1|root,COG1785@2|Bacteria,1TQCI@1239|Firmicutes,248GG@186801|Clostridia,260PD@186807|Peptococcaceae	186801|Clostridia	P	Belongs to the alkaline phosphatase family	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Alk_phosphatase,Cu_amine_oxidN1
HKD1_k127_702554_2	880071.Fleli_3672	6.108e-35	141.0	29B3Q@1|root,2ZY2C@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_702554_1	1304284.L21TH_2406	7.149e-57	213.0	COG0845@1|root,COG0845@2|Bacteria,1UUEP@1239|Firmicutes,24CTR@186801|Clostridia,36W0W@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_702554_0	1304284.L21TH_2405	1.234e-81	282.0	COG0577@1|root,COG0577@2|Bacteria,1TPHU@1239|Firmicutes,248RV@186801|Clostridia,36E94@31979|Clostridiaceae	186801|Clostridia	V	Permease	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7027003_0	293826.Amet_0977	6.123e-157	497.0	COG3855@1|root,COG3855@2|Bacteria,1TPFU@1239|Firmicutes,248ZC@186801|Clostridia,36E9Y@31979|Clostridiaceae	186801|Clostridia	G	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 3	fbp	-	3.1.3.11	ko:K04041	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_2
HKD1_k127_7027003_1	1031288.AXAA01000033_gene1356	5.933e-78	269.0	COG1284@1|root,COG1284@2|Bacteria,1TRAU@1239|Firmicutes,249DE@186801|Clostridia,36EK0@31979|Clostridiaceae	186801|Clostridia	S	hmm pf02588	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179,YitT_membrane
HKD1_k127_7030269_0	1304284.L21TH_2221	2.118e-137	447.0	COG0389@1|root,COG0389@2|Bacteria,1TP42@1239|Firmicutes,24855@186801|Clostridia,36E0M@31979|Clostridiaceae	186801|Clostridia	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD1_k127_7030832_1	720554.Clocl_2041	1.275e-20	92.0	2EAI1@1|root,334M6@2|Bacteria,1VEQH@1239|Firmicutes,24VKK@186801|Clostridia,3WKTX@541000|Ruminococcaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7030832_0	1449050.JNLE01000003_gene2498	4.214e-110	367.0	COG1055@1|root,COG1055@2|Bacteria,1TQCH@1239|Firmicutes,25CD7@186801|Clostridia,36EII@31979|Clostridiaceae	186801|Clostridia	P	Citrate transporter	-	-	-	-	-	-	-	-	-	-	-	-	CitMHS
HKD1_k127_7037753_0	484770.UFO1_2535	9.595e-48	179.0	COG1723@1|root,COG1723@2|Bacteria,1TQMD@1239|Firmicutes,4H325@909932|Negativicutes	909932|Negativicutes	S	Uncharacterised ACR, YagE family COG1723	-	-	-	-	-	-	-	-	-	-	-	-	DUF155
HKD1_k127_7037753_1	649747.HMPREF0083_01117	2.127e-32	126.0	COG1278@1|root,COG1278@2|Bacteria,1VEE0@1239|Firmicutes,4HNJC@91061|Bacilli,26YYK@186822|Paenibacillaceae	91061|Bacilli	K	Cold-shock protein	cspC	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD1_k127_7052464_0	398512.JQKC01000042_gene4156	1.263e-157	505.0	COG1453@1|root,COG1453@2|Bacteria,1TQ5N@1239|Firmicutes,247SD@186801|Clostridia,3WHHK@541000|Ruminococcaceae	186801|Clostridia	C	Psort location Cytoplasmic, score	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD1_k127_7052464_1	484770.UFO1_1752	4.086e-138	447.0	COG1902@1|root,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,4H3R9@909932|Negativicutes	909932|Negativicutes	C	PFAM NADH flavin oxidoreductase NADH oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Oxidored_FMN
HKD1_k127_7052464_2	931276.Cspa_c14570	1.522e-49	179.0	2DMS0@1|root,32T9Q@2|Bacteria,1VCJ5@1239|Firmicutes,24S8U@186801|Clostridia,36MMS@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7054164_2	1007103.AFHW01000047_gene2833	2.121e-22	100.0	COG0737@1|root,COG0737@2|Bacteria,1TPV2@1239|Firmicutes,4H9VJ@91061|Bacilli	91061|Bacilli	F	Belongs to the 5'-nucleotidase family	-	-	3.1.3.5,3.6.1.45	ko:K01081,ko:K11751	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	5_nucleotid_C,LysM,Metallophos,SLH
HKD1_k127_7054164_1	1415774.U728_29	8.307e-79	272.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,25CIK@186801|Clostridia,36WWQ@31979|Clostridiaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos
HKD1_k127_7054164_3	1408422.JHYF01000006_gene1226	2.213e-13	73.0	COG4466@1|root,COG4466@2|Bacteria,1VEQM@1239|Firmicutes,24QN2@186801|Clostridia,36KJC@31979|Clostridiaceae	186801|Clostridia	S	Biofilm formation stimulator VEG	veg	-	-	-	-	-	-	-	-	-	-	-	VEG
HKD1_k127_7054164_0	1304284.L21TH_0250	2.216e-108	359.0	COG0598@1|root,COG0598@2|Bacteria,1TPI8@1239|Firmicutes,24956@186801|Clostridia,36F99@31979|Clostridiaceae	186801|Clostridia	P	transporter	corA	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD1_k127_7055190_0	871963.Desdi_1818	1.877e-95	317.0	COG0288@1|root,COG0288@2|Bacteria,1V1YB@1239|Firmicutes,24GMG@186801|Clostridia,261GG@186807|Peptococcaceae	186801|Clostridia	P	Reversible hydration of carbon dioxide	cynT	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD1_k127_7055190_1	1280679.ATVX01000001_gene2851	6.48e-77	261.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,4BXTE@830|Butyrivibrio	186801|Clostridia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7069392_0	596324.TREVI0001_2152	1.309e-152	492.0	COG1914@1|root,COG1914@2|Bacteria	2|Bacteria	P	metal ion transmembrane transporter activity	ycsG	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD1_k127_7069392_3	1410653.JHVC01000003_gene4082	2.435e-89	300.0	COG2049@1|root,COG2049@2|Bacteria,1TTBZ@1239|Firmicutes,24A35@186801|Clostridia,36EWS@31979|Clostridiaceae	186801|Clostridia	E	Allophanate hydrolase subunit 1	kipI	-	-	ko:K06351	-	-	-	-	ko00000	-	-	-	CT_C_D
HKD1_k127_7069392_2	864565.HMPREF0379_0698	2.569e-116	384.0	COG1984@1|root,COG1984@2|Bacteria,1TR6U@1239|Firmicutes,2485K@186801|Clostridia,25UAX@186804|Peptostreptococcaceae	186801|Clostridia	E	Allophanate hydrolase subunit 2	kipA	-	-	ko:K06350	-	-	-	-	ko00000	-	-	-	CT_A_B
HKD1_k127_7069392_4	572547.Amico_0029	7.542e-18	89.0	COG5496@1|root,COG5496@2|Bacteria,3TBE7@508458|Synergistetes	508458|Synergistetes	S	Thioesterase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7069392_1	742741.HMPREF9475_00392	2.937e-119	388.0	COG4336@1|root,COG4336@2|Bacteria,1TRY8@1239|Firmicutes,248UQ@186801|Clostridia,21ZCS@1506553|Lachnoclostridium	186801|Clostridia	S	Protein of unknown function (DUF1445)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1445
HKD1_k127_7069392_5	1304284.L21TH_1564	8.774e-06	49.0	COG2144@1|root,COG2144@2|Bacteria,1V6JV@1239|Firmicutes,25EQW@186801|Clostridia,36HU8@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	AIRS
HKD1_k127_7070607_0	1304284.L21TH_0731	2.359e-99	332.0	COG1760@1|root,COG1760@2|Bacteria,1TP79@1239|Firmicutes,2480J@186801|Clostridia,36DCQ@31979|Clostridiaceae	186801|Clostridia	E	L-serine dehydratase, iron-sulfur-dependent, alpha subunit	sdaAA	-	4.3.1.17	ko:K01752	ko00260,ko00270,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00270,map01100,map01110,map01130,map01200,map01230	-	R00220,R00590	RC00331,RC02600	ko00000,ko00001,ko01000	-	-	-	SDH_alpha
HKD1_k127_7070607_2	1211817.CCAT010000085_gene1892	1.371e-39	151.0	COG0735@1|root,COG0735@2|Bacteria,1VF38@1239|Firmicutes,24SA6@186801|Clostridia,36JN2@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the Fur family	-	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD1_k127_7070607_1	1280698.AUJS01000026_gene2387	1.589e-66	233.0	2C6CR@1|root,2Z7X4@2|Bacteria,1UY2Y@1239|Firmicutes,24EJP@186801|Clostridia,27UX6@189330|Dorea	186801|Clostridia	S	Putative, 10TM heavy-metal exporter	-	-	-	ko:K07089	-	-	-	-	ko00000	-	-	-	ArsP_2
HKD1_k127_7070762_0	610130.Closa_1802	1.055e-35	140.0	COG2515@1|root,COG2515@2|Bacteria,1UDCW@1239|Firmicutes,24BXZ@186801|Clostridia,220EC@1506553|Lachnoclostridium	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	-	-	4.4.1.15	ko:K05396	ko00270,map00270	-	R01874	RC00382	ko00000,ko00001,ko01000	-	-	-	PALP
HKD1_k127_7070762_1	1121289.JHVL01000001_gene1928	1.235e-25	108.0	COG0695@1|root,COG0695@2|Bacteria,1VI6J@1239|Firmicutes,24QNT@186801|Clostridia,36N2I@31979|Clostridiaceae	186801|Clostridia	O	glutaredoxin-like protein, YruB-family	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD1_k127_7074363_2	1230342.CTM_05243	1.33e-25	106.0	COG0454@1|root,COG0454@2|Bacteria,1V9X4@1239|Firmicutes,24G56@186801|Clostridia,36I9Z@31979|Clostridiaceae	186801|Clostridia	K	Acetyltransferase GNAT family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD1_k127_7074363_0	1304284.L21TH_2681	3.797e-118	395.0	COG0741@1|root,COG0741@2|Bacteria,1UYN6@1239|Firmicutes,24HDT@186801|Clostridia,36IWV@31979|Clostridiaceae	186801|Clostridia	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	CW_binding_2,SLH,SLT
HKD1_k127_7074363_1	1304284.L21TH_2683	8.184e-73	253.0	COG1109@1|root,COG1109@2|Bacteria,1TP2N@1239|Firmicutes,2481Y@186801|Clostridia,36F97@31979|Clostridiaceae	186801|Clostridia	G	phosphoglucomutase phosphomannomutase alpha beta alpha domain II	pgcA	-	5.4.2.2,5.4.2.8	ko:K01835,ko:K01840	ko00010,ko00030,ko00051,ko00052,ko00230,ko00500,ko00520,ko00521,ko01100,ko01110,ko01120,ko01130,map00010,map00030,map00051,map00052,map00230,map00500,map00520,map00521,map01100,map01110,map01120,map01130	M00114,M00549	R00959,R01057,R01818,R08639	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_7083646_1	1122128.AUEE01000008_gene1806	2.061e-41	156.0	COG1957@1|root,COG1957@2|Bacteria,1TSSS@1239|Firmicutes,4HB17@91061|Bacilli,4GY83@90964|Staphylococcaceae	91061|Bacilli	F	inosine-uridine preferring nucleoside hydrolase	rihC	-	3.2.2.1	ko:K01239,ko:K01250,ko:K12700	ko00230,ko00760,ko01100,map00230,map00760,map01100	-	R01245,R01273,R01677,R01770,R02143	RC00033,RC00063,RC00122,RC00318,RC00485	ko00000,ko00001,ko01000	-	-	-	IU_nuc_hydro
HKD1_k127_7083646_0	1487921.DP68_05525	8.348e-80	274.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,36HMT@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_7101482_2	1408823.AXUS01000012_gene309	2.01e-13	70.0	COG1139@1|root,COG1139@2|Bacteria,1TP90@1239|Firmicutes,249B6@186801|Clostridia	186801|Clostridia	C	PFAM Uncharacterised ACR, YkgG family COG1556	-	-	-	-	-	-	-	-	-	-	-	-	LUD_dom
HKD1_k127_7101482_1	913865.DOT_1884	2.87e-45	168.0	COG0454@1|root,COG0456@2|Bacteria,1V85Q@1239|Firmicutes,24HQF@186801|Clostridia,265BE@186807|Peptococcaceae	186801|Clostridia	K	PFAM Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10
HKD1_k127_7101482_0	1449050.JNLE01000003_gene2472	2.859e-89	309.0	COG4915@1|root,COG4915@2|Bacteria,1U2SU@1239|Firmicutes,24B5W@186801|Clostridia,36FMX@31979|Clostridiaceae	186801|Clostridia	S	5-bromo-4-chloroindolyl phosphate hydrolysis protein	-	-	-	-	-	-	-	-	-	-	-	-	Halogen_Hydrol
HKD1_k127_7104546_0	1304284.L21TH_0659	3.846e-129	428.0	COG1293@1|root,COG1293@2|Bacteria,1TQ8A@1239|Firmicutes,248RK@186801|Clostridia,36DS7@31979|Clostridiaceae	186801|Clostridia	K	Fibronectin-binding protein	FbpA	-	-	-	-	-	-	-	-	-	-	-	DUF814,FbpA
HKD1_k127_7118533_1	1304284.L21TH_0674	5.922e-12	70.0	COG0515@1|root,COG0515@2|Bacteria,1TP3F@1239|Firmicutes,2492G@186801|Clostridia,36DBS@31979|Clostridiaceae	186801|Clostridia	KLT	serine threonine protein kinase	prkC	-	2.7.11.1	ko:K12132	-	-	-	-	ko00000,ko01000,ko01001	-	-	-	PASTA,Pkinase
HKD1_k127_7118533_0	1304284.L21TH_0675	2.024e-85	290.0	COG1162@1|root,COG1162@2|Bacteria,1TPSQ@1239|Firmicutes,248R5@186801|Clostridia,36ETW@31979|Clostridiaceae	186801|Clostridia	S	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit	rsgA	-	3.1.3.100	ko:K06949	ko00730,ko01100,map00730,map01100	-	R00615,R02135	RC00002,RC00017	ko00000,ko00001,ko01000,ko03009	-	-	-	RsgA_GTPase,RsgA_N
HKD1_k127_713397_1	469616.FMAG_00106	2.544e-88	294.0	COG2820@1|root,COG2820@2|Bacteria,379GP@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_713397_0	1304880.JAGB01000002_gene1700	2.34e-194	619.0	COG0534@1|root,COG0534@2|Bacteria,1TQMT@1239|Firmicutes,249WJ@186801|Clostridia	186801|Clostridia	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_713397_2	1105031.HMPREF1141_3093	4.225e-30	121.0	COG4905@1|root,COG4905@2|Bacteria,1VA0H@1239|Firmicutes,24NAK@186801|Clostridia,36MWU@31979|Clostridiaceae	186801|Clostridia	S	Putative ABC-transporter type IV	-	-	-	-	-	-	-	-	-	-	-	-	ABC_trans_CmpB
HKD1_k127_7135851_0	1227352.C173_00450	9.27e-44	177.0	COG5492@1|root,COG5492@2|Bacteria,1V17S@1239|Firmicutes,4IPRD@91061|Bacilli,2762B@186822|Paenibacillaceae	91061|Bacilli	N	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_7135851_1	1410670.JHXF01000007_gene756	4.722e-07	51.0	COG3409@1|root,COG3409@2|Bacteria,1TS29@1239|Firmicutes,247SQ@186801|Clostridia,3WGZA@541000|Ruminococcaceae	186801|Clostridia	M	peptidoglycan binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	LysM,PG_binding_1,SpoIID
HKD1_k127_7142306_1	1347392.CCEZ01000049_gene1367	7.261e-53	190.0	COG0083@1|root,COG0083@2|Bacteria,1TRWS@1239|Firmicutes,248NA@186801|Clostridia,36FBC@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate	thrB	-	2.7.1.39	ko:K00872	ko00260,ko01100,ko01110,ko01120,ko01230,map00260,map01100,map01110,map01120,map01230	M00018	R01771	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS03525	GHMP_kinases_C,GHMP_kinases_N
HKD1_k127_7142306_0	1408439.JHXW01000003_gene1622	2.527e-97	325.0	COG0498@1|root,COG0498@2|Bacteria,378C2@32066|Fusobacteria	32066|Fusobacteria	E	Threonine synthase	thrC	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_synth_N
HKD1_k127_7154034_0	1304284.L21TH_0348	4.04e-157	503.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,36DT4@31979|Clostridiaceae	186801|Clostridia	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HKD1_k127_7161054_1	1298920.KI911353_gene4076	4.819e-26	115.0	COG1317@1|root,COG1317@2|Bacteria,1V9VJ@1239|Firmicutes,25P71@186801|Clostridia,220KN@1506553|Lachnoclostridium	186801|Clostridia	NU	bacterial-type flagellum organization	-	-	-	ko:K02411	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	FliH
HKD1_k127_7161054_0	658655.HMPREF0988_00768	6.798e-167	531.0	COG1157@1|root,COG1157@2|Bacteria,1TP0R@1239|Firmicutes,25E6B@186801|Clostridia,27IZJ@186928|unclassified Lachnospiraceae	186801|Clostridia	N	ATP synthase alpha/beta family, nucleotide-binding domain	fliI	-	3.6.3.14	ko:K02412,ko:K03224	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko01000,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD1_k127_7167653_1	742738.HMPREF9460_02349	1.125e-20	101.0	COG2373@1|root,COG2373@2|Bacteria,1UMXC@1239|Firmicutes,25GRM@186801|Clostridia,268M2@186813|unclassified Clostridiales	186801|Clostridia	S	S-layer homology domain	-	-	-	-	-	-	-	-	-	-	-	-	SLH
HKD1_k127_7167653_0	1304284.L21TH_1767	1.105e-76	268.0	COG0265@1|root,COG0265@2|Bacteria,1TRM8@1239|Firmicutes,247M5@186801|Clostridia,36DM2@31979|Clostridiaceae	186801|Clostridia	O	PDZ DHR GLGF domain protein	htrA	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD1_k127_7169078_0	394503.Ccel_0901	3.798e-63	228.0	COG3858@1|root,COG3858@2|Bacteria,1UJN3@1239|Firmicutes,25F62@186801|Clostridia,36UXG@31979|Clostridiaceae	186801|Clostridia	S	PFAM copper amine oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Cu_amine_oxidN1
HKD1_k127_7169078_1	1196322.A370_01671	7.674e-08	53.0	COG0655@1|root,COG0655@2|Bacteria,1TT84@1239|Firmicutes,248W0@186801|Clostridia,36E3H@31979|Clostridiaceae	186801|Clostridia	S	NADPH-dependent FMN reductase	-	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD1_k127_717825_2	1354300.AUQY01000002_gene841	6.833e-47	174.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,22GM5@1570339|Peptoniphilaceae	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_717825_3	1304284.L21TH_1259	6.735e-22	97.0	COG0317@1|root,COG0317@2|Bacteria,1TNYZ@1239|Firmicutes,2489A@186801|Clostridia,36EH5@31979|Clostridiaceae	186801|Clostridia	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	relA	-	2.7.6.5	ko:K00951	ko00230,map00230	-	R00429	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS16615	ACT_4,HD_4,RelA_SpoT,TGS
HKD1_k127_717825_1	865861.AZSU01000003_gene1576	1.987e-56	200.0	COG1490@1|root,COG1490@2|Bacteria,1V6GH@1239|Firmicutes,24J90@186801|Clostridia,36J4D@31979|Clostridiaceae	186801|Clostridia	J	rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality	dtd	-	-	ko:K07560	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Tyr_Deacylase
HKD1_k127_717825_0	1121289.JHVL01000004_gene2042	6.944e-65	228.0	COG0491@1|root,COG0491@2|Bacteria,1V6FA@1239|Firmicutes,24JGV@186801|Clostridia,36I3Z@31979|Clostridiaceae	186801|Clostridia	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD1_k127_717825_4	1295642.H839_02416	0.0003645	49.0	COG0635@1|root,COG0635@2|Bacteria,1TREM@1239|Firmicutes,4HC2D@91061|Bacilli,1WE92@129337|Geobacillus	91061|Bacilli	H	Elongator protein 3, MiaB family, Radical SAM	hemZ	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD1_k127_7180925_0	332101.JIBU02000039_gene1711	2.221e-96	327.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_8,PAS,PAS_4,PAS_8,PAS_9,Sigma54_activat
HKD1_k127_7184052_0	1408422.JHYF01000003_gene922	9.369e-107	364.0	COG0457@1|root,COG1672@1|root,COG3629@1|root,COG0457@2|Bacteria,COG1672@2|Bacteria,COG3629@2|Bacteria,1TR6V@1239|Firmicutes,24AA2@186801|Clostridia,36DWM@31979|Clostridiaceae	186801|Clostridia	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	AAA_16,BTAD,TPR_12,Trans_reg_C
HKD1_k127_7195431_1	1121289.JHVL01000002_gene2410	1.878e-23	103.0	COG1530@1|root,COG1530@2|Bacteria,1TQS4@1239|Firmicutes,247QV@186801|Clostridia,36EIM@31979|Clostridiaceae	186801|Clostridia	J	ribonuclease, Rne Rng family	rng	-	-	ko:K08301	-	-	-	-	ko00000,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1,TRAM
HKD1_k127_7195431_0	1304284.L21TH_2121	1.409e-39	155.0	COG5011@1|root,COG5011@2|Bacteria,1V4D0@1239|Firmicutes,249GU@186801|Clostridia,36EY8@31979|Clostridiaceae	186801|Clostridia	S	Radical SAM-linked protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2344
HKD1_k127_7216065_1	697303.Thewi_0261	2.055e-49	184.0	COG3857@1|root,COG3857@2|Bacteria,1TQJW@1239|Firmicutes,2487T@186801|Clostridia,42FJ1@68295|Thermoanaerobacterales	186801|Clostridia	L	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddB nuclease domain is not required for chi fragment generation	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Exonuc_V_gamma,PDDEXK_1,UvrD_C
HKD1_k127_7216065_0	1128398.Curi_c19090	6.255e-144	474.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,268GR@186813|unclassified Clostridiales	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_7219404_1	768710.DesyoDRAFT_3224	2.096e-32	138.0	COG2223@1|root,COG2223@2|Bacteria,1TPTN@1239|Firmicutes,25EM4@186801|Clostridia,261F9@186807|Peptococcaceae	186801|Clostridia	P	PFAM Major Facilitator Superfamily	-	-	-	ko:K08223	-	-	-	-	ko00000,ko02000	2.A.1.35	-	-	MFS_1
HKD1_k127_7219404_0	1403313.AXBR01000013_gene1387	1.4e-41	161.0	COG0684@1|root,COG0684@2|Bacteria,1V1ME@1239|Firmicutes,4HGQE@91061|Bacilli,1ZB81@1386|Bacillus	91061|Bacilli	H	Methyltransferase	-	-	4.1.3.17	ko:K10218	ko00362,ko00660,ko01120,map00362,map00660,map01120	-	R00008,R00350	RC00067,RC00502,RC01205	ko00000,ko00001,ko01000	-	-	-	RraA-like
HKD1_k127_7227478_0	1105031.HMPREF1141_0204	6.611e-196	621.0	COG0064@1|root,COG0064@2|Bacteria,1TPG3@1239|Firmicutes,247MS@186801|Clostridia,36E2U@31979|Clostridiaceae	186801|Clostridia	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD1_k127_7227478_1	1120746.CCNL01000014_gene2197	1.697e-29	118.0	COG0154@1|root,COG0154@2|Bacteria,2NNSD@2323|unclassified Bacteria	2|Bacteria	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD1_k127_7231088_2	1120998.AUFC01000002_gene2857	2.459e-132	445.0	COG0392@1|root,COG2898@1|root,COG0392@2|Bacteria,COG2898@2|Bacteria,1TQI2@1239|Firmicutes,24BRW@186801|Clostridia	186801|Clostridia	I	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms	mprF	-	2.3.2.3	ko:K14205	ko01503,ko02020,ko05150,map01503,map02020,map05150	M00726	-	-	ko00000,ko00001,ko00002,ko01000,ko01504	2.A.1.3.37	-	-	DUF2156,LPG_synthase_TM
HKD1_k127_7231088_1	545243.BAEV01000008_gene1193	5.893e-155	501.0	COG0586@1|root,COG0586@2|Bacteria,1UVK3@1239|Firmicutes,24E6A@186801|Clostridia,36W8T@31979|Clostridiaceae	186801|Clostridia	S	PFAM SNARE associated Golgi protein	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2,SNARE_assoc
HKD1_k127_7231088_0	1304866.K413DRAFT_2004	3.64e-240	745.0	COG0369@1|root,COG1151@2|Bacteria,1TRSC@1239|Firmicutes,248HQ@186801|Clostridia,36DKP@31979|Clostridiaceae	186801|Clostridia	C	TIGRFAM Carbon-monoxide dehydrogenase, catalytic subunit	cooS	-	1.2.7.4	ko:K00198	ko00633,ko00680,ko00720,ko01120,ko01200,map00633,map00680,map00720,map01120,map01200	M00377	R07157,R08034	RC00250,RC02800	ko00000,ko00001,ko00002,ko01000	-	-	-	Prismane
HKD1_k127_7239388_0	1128398.Curi_c16860	1.264e-200	651.0	COG1198@1|root,COG1198@2|Bacteria,1TNYB@1239|Firmicutes,248EI@186801|Clostridia,268ES@186813|unclassified Clostridiales	186801|Clostridia	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,ResIII
HKD1_k127_7239388_1	1347392.CCEZ01000043_gene524	4.353e-49	179.0	COG0242@1|root,COG0242@2|Bacteria,1V70B@1239|Firmicutes,24JET@186801|Clostridia,36IPZ@31979|Clostridiaceae	186801|Clostridia	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD1_k127_7239388_2	138119.DSY2693	8.307e-29	117.0	COG0223@1|root,COG0223@2|Bacteria,1TQ32@1239|Firmicutes,248ED@186801|Clostridia,260EN@186807|Peptococcaceae	186801|Clostridia	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD1_k127_7247798_1	203119.Cthe_3015	3.871e-25	105.0	COG0298@1|root,COG0298@2|Bacteria	2|Bacteria	O	carbon dioxide binding	hypC	-	-	ko:K04653,ko:K04654	-	-	-	-	ko00000	-	-	-	HupF_HypC
HKD1_k127_7247798_0	203119.Cthe_3016	6.092e-132	426.0	COG0068@1|root,COG0068@2|Bacteria,1TQM7@1239|Firmicutes,2494A@186801|Clostridia,3WHQ8@541000|Ruminococcaceae	186801|Clostridia	O	Belongs to the carbamoyltransferase HypF family	hypF	-	-	ko:K04656	-	-	-	-	ko00000	-	-	-	Acylphosphatase,Sua5_yciO_yrdC,zf-HYPF
HKD1_k127_7293902_3	1304284.L21TH_1325	2.806e-40	153.0	COG0020@1|root,COG0020@2|Bacteria,1TQTS@1239|Firmicutes,247TE@186801|Clostridia,36DDR@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD1_k127_7293902_2	997350.HMPREF9129_1738	2.321e-70	242.0	COG0233@1|root,COG0233@2|Bacteria,1V1F2@1239|Firmicutes,24HWS@186801|Clostridia,22HD3@1570339|Peptoniphilaceae	186801|Clostridia	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD1_k127_7293902_1	1304284.L21TH_1322	1.332e-110	361.0	COG0528@1|root,COG0528@2|Bacteria,1TPXN@1239|Firmicutes,247KR@186801|Clostridia,36DV4@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_7293902_0	1511.CLOST_1704	6.602e-125	407.0	COG0264@1|root,COG0264@2|Bacteria,1TPFJ@1239|Firmicutes,248J2@186801|Clostridia,25QWI@186804|Peptostreptococcaceae	186801|Clostridia	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD1_k127_7312956_0	931276.Cspa_c46710	2.731e-43	162.0	COG1307@1|root,COG1307@2|Bacteria,1TSKD@1239|Firmicutes,24AE9@186801|Clostridia,36F3I@31979|Clostridiaceae	186801|Clostridia	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_7312956_2	1443125.Z962_11410	7.321e-29	117.0	COG2827@1|root,COG2827@2|Bacteria,1VEZF@1239|Firmicutes,24QYU@186801|Clostridia,36KS5@31979|Clostridiaceae	186801|Clostridia	L	Excinuclease ABC C subunit domain protein	-	-	-	ko:K07461	-	-	-	-	ko00000	-	-	-	GIY-YIG
HKD1_k127_7312956_1	537013.CLOSTMETH_01086	2.71e-39	150.0	COG0775@1|root,COG0775@2|Bacteria,1U7WK@1239|Firmicutes,247U5@186801|Clostridia,3WI24@541000|Ruminococcaceae	186801|Clostridia	E	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively	mtnN	-	3.2.2.9	ko:K01243	ko00270,ko01100,ko01230,map00270,map01100,map01230	M00034,M00609	R00194,R01401	RC00063,RC00318	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_7317884_2	1209989.TepiRe1_0117	7.836e-44	166.0	COG2185@1|root,COG2185@2|Bacteria,1V45Q@1239|Firmicutes,24HGC@186801|Clostridia,42GMZ@68295|Thermoanaerobacterales	186801|Clostridia	I	Catalyzes the carbon skeleton rearrangement of L- glutamate to L-threo-3-methylaspartate ((2S,3S)-3- methylaspartate)	mamA	-	5.4.99.1	ko:K01846	ko00630,ko00660,ko01100,ko01200,map00630,map00660,map01100,map01200	M00740	R00262	RC01221	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding
HKD1_k127_7317884_0	891968.Anamo_1294	7.112e-94	317.0	COG2513@1|root,COG2513@2|Bacteria,3TAPQ@508458|Synergistetes	508458|Synergistetes	G	Phosphoenolpyruvate phosphomutase	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HKD1_k127_7317884_1	1449126.JQKL01000004_gene522	1.633e-55	206.0	COG3181@1|root,COG3181@2|Bacteria,1V0HH@1239|Firmicutes,24HV2@186801|Clostridia,26BEC@186813|unclassified Clostridiales	186801|Clostridia	S	Tripartite tricarboxylate transporter family receptor	-	-	-	-	-	-	-	-	-	-	-	-	TctC
HKD1_k127_73205_0	180332.JTGN01000023_gene1638	5.832e-234	730.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia	186801|Clostridia	S	Abc transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_73205_1	1449050.JNLE01000005_gene5160	3.555e-96	319.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,36EKF@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_7337516_0	1291050.JAGE01000002_gene3459	2.633e-222	704.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_7337516_1	1476973.JMMB01000007_gene2072	5.994e-19	89.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia	186801|Clostridia	V	ABC transporter	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_7337545_0	411462.DORLON_02252	9.766e-71	244.0	COG3601@1|root,COG3601@2|Bacteria,1V4BW@1239|Firmicutes,24E4V@186801|Clostridia,27VHX@189330|Dorea	186801|Clostridia	U	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins	ribU	-	-	-	-	-	-	-	-	-	-	-	ECF_trnsprt
HKD1_k127_7337545_1	1414720.CBYM010000008_gene1021	2.974e-70	247.0	COG3854@1|root,COG3854@2|Bacteria,1TQ23@1239|Firmicutes,248S2@186801|Clostridia,36E2F@31979|Clostridiaceae	186801|Clostridia	S	stage III sporulation protein AA	spoIIIAA	-	-	ko:K06390	-	-	-	-	ko00000	-	-	-	T2SSE
HKD1_k127_7341484_1	1131462.DCF50_p2203	5.764e-28	123.0	2D89T@1|root,32TQU@2|Bacteria,1VDHI@1239|Firmicutes	1239|Firmicutes	S	Psort location CytoplasmicMembrane, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7341484_0	1410653.JHVC01000001_gene1860	2.669e-132	424.0	COG0402@1|root,COG0402@2|Bacteria,1TP43@1239|Firmicutes,248IX@186801|Clostridia,36FIQ@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine	mtaD	-	3.5.4.28,3.5.4.31	ko:K12960	ko00270,ko01100,map00270,map01100	-	R09660	RC00477	ko00000,ko00001,ko01000	-	-	-	Amidohydro_1
HKD1_k127_7352372_2	1304284.L21TH_2698	1.637e-107	359.0	COG2208@1|root,COG2208@2|Bacteria,1TQY5@1239|Firmicutes,249WB@186801|Clostridia,36EX3@31979|Clostridiaceae	186801|Clostridia	KT	Stage II sporulation E family protein	-	-	3.1.3.3	ko:K07315	-	-	-	-	ko00000,ko01000,ko03021	-	-	-	PAS_4,PAS_9,SpoIIE
HKD1_k127_7352372_1	1347392.CCEZ01000049_gene1601	1.706e-117	386.0	COG0391@1|root,COG0391@2|Bacteria,1TPNV@1239|Firmicutes,248G0@186801|Clostridia,36EUV@31979|Clostridiaceae	186801|Clostridia	S	Required for morphogenesis under gluconeogenic growth conditions	-	-	-	-	-	-	-	-	-	-	-	-	UPF0052
HKD1_k127_7352372_0	1304284.L21TH_1529	2.587e-126	409.0	COG1660@1|root,COG1660@2|Bacteria,1TPS4@1239|Firmicutes,248KQ@186801|Clostridia,36DI8@31979|Clostridiaceae	186801|Clostridia	S	Displays ATPase and GTPase activities	yvcJ	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD1_k127_7352372_4	334413.FMG_1085	8.153e-74	256.0	COG1387@1|root,COG1387@2|Bacteria,1TQ33@1239|Firmicutes,24CMU@186801|Clostridia,22J0G@1570339|Peptoniphilaceae	186801|Clostridia	E	DNA polymerase alpha chain like domain	-	-	-	ko:K04477	-	-	-	-	ko00000	-	-	-	PHP
HKD1_k127_7352372_3	1304284.L21TH_1532	1.426e-102	342.0	COG0812@1|root,COG0812@2|Bacteria,1TP3W@1239|Firmicutes,247IU@186801|Clostridia,36DWB@31979|Clostridiaceae	186801|Clostridia	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD1_k127_7352372_5	1304284.L21TH_0303	7.597e-38	144.0	COG1473@1|root,COG1473@2|Bacteria,1TQ7B@1239|Firmicutes,2492H@186801|Clostridia,36EX4@31979|Clostridiaceae	186801|Clostridia	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD1_k127_7357183_1	1408823.AXUS01000013_gene1230	1.767e-29	119.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	fldZ	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_7357183_0	573061.Clocel_2000	2.602e-225	725.0	COG0642@1|root,COG5002@1|root,COG2205@2|Bacteria,COG5002@2|Bacteria,1TQMV@1239|Firmicutes,247SE@186801|Clostridia,36ERF@31979|Clostridiaceae	186801|Clostridia	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_9,dCache_1
HKD1_k127_7372860_0	195103.CPF_2903	3.827e-177	563.0	COG0014@1|root,COG0014@2|Bacteria,1TQ9V@1239|Firmicutes,248NX@186801|Clostridia,36DHK@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate	proA	-	1.2.1.41	ko:K00147	ko00330,ko00332,ko01100,ko01110,ko01130,ko01230,map00330,map00332,map01100,map01110,map01130,map01230	M00015	R03313	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD1_k127_7372860_1	908340.HMPREF9406_3347	1.491e-97	326.0	COG0263@1|root,COG0263@2|Bacteria,1TPG6@1239|Firmicutes,2486P@186801|Clostridia,36DG7@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate	proB	-	2.7.2.11	ko:K00931	ko00330,ko00332,ko01100,ko01130,ko01230,map00330,map00332,map01100,map01130,map01230	M00015	R00239	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,PUA
HKD1_k127_7376341_3	1401067.HMPREF0872_08390	2.215e-61	216.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4H41D@909932|Negativicutes	909932|Negativicutes	I	enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_7376341_4	861450.HMPREF0080_00781	2.884e-20	92.0	COG1024@1|root,COG1024@2|Bacteria,1TQ2V@1239|Firmicutes,4H41D@909932|Negativicutes	909932|Negativicutes	I	enoyl-CoA hydratase isomerase family	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD1_k127_7376341_1	2754.EH55_05725	4.578e-95	319.0	COG1319@1|root,COG1319@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.2.5.3	ko:K03519	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	CO_deh_flav_C,FAD_binding_5
HKD1_k127_7376341_2	2754.EH55_05720	5.992e-71	243.0	COG2080@1|root,COG2080@2|Bacteria	2|Bacteria	C	2 iron, 2 sulfur cluster binding	-	-	1.2.5.3,1.3.99.16	ko:K03518,ko:K07302	-	-	R11168	RC02800	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2,Fer2,Fer2_2
HKD1_k127_7376341_0	2754.EH55_05715	1.076e-301	944.0	COG1529@1|root,COG1529@2|Bacteria	2|Bacteria	C	xanthine dehydrogenase activity	-	-	1.17.1.4	ko:K00087	ko00230,ko01100,ko01120,map00230,map01100,map01120	M00546	R01768,R02103	RC00143	ko00000,ko00001,ko00002,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD1_k127_7377493_0	1321778.HMPREF1982_02759	1.337e-275	857.0	COG3383@1|root,COG4624@1|root,COG3383@2|Bacteria,COG4624@2|Bacteria,1TP6C@1239|Firmicutes,24897@186801|Clostridia,267NJ@186813|unclassified Clostridiales	186801|Clostridia	C	Iron hydrogenase small subunit	-	-	1.12.1.3,1.6.5.3	ko:K00336,ko:K18332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	iHN637.CLJU_RS07205	Fe_hyd_SSU,Fe_hyd_lg_C,Fer2_4,Fer4,Fer4_7,Fer4_9,NADH-G_4Fe-4S_3
HKD1_k127_7377493_1	536227.CcarbDRAFT_3709	5.242e-128	411.0	COG1894@1|root,COG1894@2|Bacteria,1TQB0@1239|Firmicutes,2483E@186801|Clostridia,36EMP@31979|Clostridiaceae	186801|Clostridia	C	Respiratory-chain NADH dehydrogenase domain 51 kDa subunit	-	-	1.12.1.3,1.6.5.3	ko:K00335,ko:K18331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx,Complex1_51K,Fer4,NADH_4Fe-4S,SLBB
HKD1_k127_7382198_1	575593.HMPREF0491_02528	3.488e-69	235.0	COG0369@1|root,COG1251@1|root,COG1151@2|Bacteria,COG1251@2|Bacteria,1TP8X@1239|Firmicutes,247IN@186801|Clostridia,27K9K@186928|unclassified Lachnospiraceae	186801|Clostridia	C	Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O	hcp	-	1.7.99.1	ko:K05601	ko00910,map00910	-	R00143	RC02797	ko00000,ko00001,ko01000	-	-	-	DUF1858,Prismane
HKD1_k127_7382198_0	484770.UFO1_3915	7.558e-125	405.0	COG1741@1|root,COG1741@2|Bacteria,1TQDV@1239|Firmicutes,4H3MQ@909932|Negativicutes	909932|Negativicutes	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD1_k127_7382198_2	208596.CAR_c11650	3.482e-37	146.0	COG1408@1|root,COG1408@2|Bacteria,1UU17@1239|Firmicutes,4HC8Q@91061|Bacilli,27I1N@186828|Carnobacteriaceae	91061|Bacilli	S	Calcineurin-like phosphoesterase superfamily domain	ykuE	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD1_k127_7410875_0	1410653.JHVC01000002_gene4430	2.456e-112	378.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,Sigma54_activat
HKD1_k127_7413088_0	994573.T472_0202845	1.879e-179	567.0	COG2233@1|root,COG2233@2|Bacteria,1TQKX@1239|Firmicutes,2485Z@186801|Clostridia,36DN5@31979|Clostridiaceae	186801|Clostridia	F	Permease	uraA	-	-	ko:K02824	-	-	-	-	ko00000,ko02000	2.A.40.1.1,2.A.40.1.2	-	-	Xan_ur_permease
HKD1_k127_7415009_0	1304284.L21TH_1546	3.726e-194	616.0	COG0653@1|root,COG0653@2|Bacteria,1TPEY@1239|Firmicutes,247N2@186801|Clostridia,36DNR@31979|Clostridiaceae	186801|Clostridia	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	Helicase_C,SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD1_k127_7416157_0	394503.Ccel_1770	2.185e-155	496.0	COG1132@1|root,COG1132@2|Bacteria,1TP0B@1239|Firmicutes,247Q0@186801|Clostridia,36E82@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter transmembrane region	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_7416157_1	545697.HMPREF0216_02336	8.126e-39	151.0	COG4720@1|root,COG4720@2|Bacteria,1VF2R@1239|Firmicutes,24QR3@186801|Clostridia,36G1D@31979|Clostridiaceae	186801|Clostridia	S	ECF-type riboflavin transporter, S component	-	-	-	-	-	-	-	-	-	-	-	-	ECF-ribofla_trS
HKD1_k127_7418386_2	1297617.JPJD01000035_gene641	2.07e-19	91.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,2692H@186813|unclassified Clostridiales	186801|Clostridia	E	ABC transporter, substrate-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_7418386_0	1232443.BAIA02000077_gene258	2.293e-94	318.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,268J5@186813|unclassified Clostridiales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	-	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_7418386_1	1297617.JPJD01000035_gene643	1.051e-65	230.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,269ZR@186813|unclassified Clostridiales	186801|Clostridia	EP	N-terminal TM domain of oligopeptide transport permease C	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N
HKD1_k127_7428726_0	1196322.A370_05288	1.961e-194	611.0	COG0019@1|root,COG0019@2|Bacteria,1TPQI@1239|Firmicutes,248NH@186801|Clostridia,36EBU@31979|Clostridiaceae	186801|Clostridia	E	carboxynorspermidine decarboxylase	nspC	-	4.1.1.96	ko:K13747	ko00330,ko01100,map00330,map01100	-	R09081,R09082	RC00299	ko00000,ko00001,ko01000	-	-	-	Orn_DAP_Arg_deC
HKD1_k127_7428726_1	1134413.ANNK01000134_gene3087	8.952e-49	174.0	COG1748@1|root,COG1748@2|Bacteria,1TQTN@1239|Firmicutes,4HA8B@91061|Bacilli,1ZAPG@1386|Bacillus	91061|Bacilli	E	Saccharopine dehydrogenase	LYS1	-	1.5.1.7	ko:K00290	ko00300,ko00310,ko01100,ko01110,ko01130,ko01230,map00300,map00310,map01100,map01110,map01130,map01230	M00030,M00032	R00715	RC00217,RC01532	ko00000,ko00001,ko00002,ko01000	-	-	-	Sacchrp_dh_C,Sacchrp_dh_NADP
HKD1_k127_7445437_1	394503.Ccel_1807	1.832e-76	267.0	COG1368@1|root,COG1368@2|Bacteria,1TRMA@1239|Firmicutes,2480C@186801|Clostridia,36GR9@31979|Clostridiaceae	186801|Clostridia	M	Sulfatase	-	-	-	-	-	-	-	-	-	-	-	-	Sulfatase
HKD1_k127_7445437_0	469618.FVAG_00072	6.759e-146	469.0	COG3191@1|root,COG3191@2|Bacteria,37BDV@32066|Fusobacteria	32066|Fusobacteria	EQ	Peptidase family S58	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S58
HKD1_k127_7445437_2	1304284.L21TH_0427	1.203e-65	232.0	COG0111@1|root,COG0111@2|Bacteria,1TSDK@1239|Firmicutes,247Q4@186801|Clostridia,36DNH@31979|Clostridiaceae	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_7448459_0	1304284.L21TH_2434	1.619e-93	310.0	COG0035@1|root,COG0035@2|Bacteria,1TPMT@1239|Firmicutes,248FV@186801|Clostridia,36DZ9@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate	upp	-	2.4.2.9	ko:K00761	ko00240,ko01100,map00240,map01100	-	R00966	RC00063	ko00000,ko00001,ko01000	-	-	-	UPRTase
HKD1_k127_7448459_1	941824.TCEL_01610	2.249e-32	129.0	COG0736@1|root,COG0736@2|Bacteria,1VA0T@1239|Firmicutes,24RC0@186801|Clostridia,36KTT@31979|Clostridiaceae	186801|Clostridia	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	iHN637.CLJU_RS01470	ACPS
HKD1_k127_746039_0	1304284.L21TH_2688	9.254e-148	470.0	COG0050@1|root,COG0050@2|Bacteria,1TPKC@1239|Firmicutes,2485I@186801|Clostridia,36E5N@31979|Clostridiaceae	186801|Clostridia	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD1_k127_746039_4	1304284.L21TH_0452	2.561e-21	93.0	COG0267@1|root,COG0267@2|Bacteria,1VEJ4@1239|Firmicutes,24QK0@186801|Clostridia,36MJQ@31979|Clostridiaceae	186801|Clostridia	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD1_k127_746039_5	1121289.JHVL01000060_gene2539	4.487e-11	65.0	COG0690@1|root,COG0690@2|Bacteria	2|Bacteria	U	P-P-bond-hydrolysis-driven protein transmembrane transporter activity	secE	GO:0005575,GO:0005618,GO:0005623,GO:0005886,GO:0005887,GO:0008150,GO:0016020,GO:0016021,GO:0030312,GO:0031224,GO:0031226,GO:0040007,GO:0044425,GO:0044459,GO:0044464,GO:0071944	-	ko:K03073	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecE
HKD1_k127_746039_1	1304284.L21TH_0450	1.353e-81	274.0	COG0250@1|root,COG0250@2|Bacteria,1TR3P@1239|Firmicutes,248XB@186801|Clostridia,36F5J@31979|Clostridiaceae	186801|Clostridia	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD1_k127_746039_2	1304284.L21TH_0449	6.59e-68	233.0	COG0080@1|root,COG0080@2|Bacteria,1V1BS@1239|Firmicutes,24FSQ@186801|Clostridia,36I00@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD1_k127_746039_3	720554.Clocl_0652	3.963e-42	156.0	COG0081@1|root,COG0081@2|Bacteria,1TPTS@1239|Firmicutes,247JB@186801|Clostridia,3WH4A@541000|Ruminococcaceae	186801|Clostridia	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD1_k127_7465932_0	1105031.HMPREF1141_2133	1.241e-95	314.0	COG2987@1|root,COG2987@2|Bacteria,1TPZ9@1239|Firmicutes,247YS@186801|Clostridia,36DK8@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD1_k127_7465932_1	679200.HMPREF9333_00981	2.376e-26	108.0	COG2759@1|root,COG2759@2|Bacteria,1TP6N@1239|Firmicutes,247P5@186801|Clostridia	186801|Clostridia	H	Belongs to the formate--tetrahydrofolate ligase family	fhs	-	6.3.4.3	ko:K01938	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R00943	RC00026,RC00111	ko00000,ko00001,ko00002,ko01000	-	-	-	FTHFS
HKD1_k127_7466807_0	1163671.JAGI01000002_gene3261	1.667e-45	176.0	COG0477@1|root,COG2814@2|Bacteria,1UKNU@1239|Firmicutes,24KJE@186801|Clostridia,36M73@31979|Clostridiaceae	186801|Clostridia	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD1_k127_7466807_1	158189.SpiBuddy_0012	3.706e-27	118.0	COG2345@1|root,COG2345@2|Bacteria	2|Bacteria	K	Transcriptional regulator	-	-	-	ko:K03724,ko:K15545	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	DEAD,DEAD_assoc,HTH_20,HTH_24,HTH_5,Helicase_C,ROK
HKD1_k127_7466807_2	1499683.CCFF01000014_gene3691	3.214e-06	49.0	COG2906@1|root,COG2906@2|Bacteria,1V246@1239|Firmicutes,25DRN@186801|Clostridia,36UE7@31979|Clostridiaceae	186801|Clostridia	P	PFAM BFD domain protein 2Fe-2S -binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
HKD1_k127_7470088_2	871963.Desdi_1075	3.443e-59	206.0	COG0640@1|root,COG0640@2|Bacteria,1VA6G@1239|Firmicutes,24JCN@186801|Clostridia,265HQ@186807|Peptococcaceae	186801|Clostridia	K	PFAM Bacterial regulatory protein, arsR family	ziaR	-	-	ko:K21903	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD1_k127_7470088_5	562981.HMPREF0428_00609	3.441e-27	112.0	COG2608@1|root,COG2608@2|Bacteria,1VEM6@1239|Firmicutes,4HN63@91061|Bacilli	91061|Bacilli	P	Heavy-metal-associated domain	-	-	-	-	-	-	-	-	-	-	-	-	HMA
HKD1_k127_7470088_0	883114.HMPREF9709_01856	1.718e-209	657.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,22FZN@1570339|Peptoniphilaceae	186801|Clostridia	P	cadmium-exporting ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_7470088_1	883114.HMPREF9709_01856	1.022e-86	289.0	COG2217@1|root,COG2217@2|Bacteria,1TQ07@1239|Firmicutes,248EH@186801|Clostridia,22FZN@1570339|Peptoniphilaceae	186801|Clostridia	P	cadmium-exporting ATPase	cadA	-	3.6.3.3,3.6.3.5	ko:K01534	-	-	-	-	ko00000,ko01000	3.A.3.6	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_7470088_6	865861.AZSU01000003_gene1871	3.532e-09	62.0	2DPRM@1|root,3333W@2|Bacteria,1UPZN@1239|Firmicutes,24SAT@186801|Clostridia,36NG6@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
HKD1_k127_7470088_3	1121289.JHVL01000005_gene1002	1.574e-51	188.0	COG2431@1|root,COG2431@2|Bacteria,1V44M@1239|Firmicutes,24I3B@186801|Clostridia,36ID9@31979|Clostridiaceae	186801|Clostridia	S	Lysine exporter LysO	-	-	-	-	-	-	-	-	-	-	-	-	Lys_export
HKD1_k127_7470088_4	386415.NT01CX_2076	1.321e-40	157.0	COG0406@1|root,COG0406@2|Bacteria,1V6ES@1239|Firmicutes,24BUG@186801|Clostridia,36IHG@31979|Clostridiaceae	186801|Clostridia	G	Belongs to the phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD1_k127_7482096_1	1120746.CCNL01000011_gene1489	1.284e-39	154.0	COG1377@1|root,COG1377@2|Bacteria,2NPBX@2323|unclassified Bacteria	2|Bacteria	N	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin	flhB	-	-	ko:K02401,ko:K03229,ko:K04061,ko:K13820,ko:K22510	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	Bac_export_2
HKD1_k127_7482096_0	1120746.CCNL01000011_gene1488	1.52e-55	203.0	COG1684@1|root,COG1684@2|Bacteria,2NQ2G@2323|unclassified Bacteria	2|Bacteria	N	Bacterial export proteins, family 1	fliR	-	-	ko:K02421,ko:K03228,ko:K13820	ko02040,ko03070,map02040,map03070	M00332,M00542,M00660	-	-	ko00000,ko00001,ko00002,ko02035,ko02044	3.A.6.1,3.A.6.2,3.A.6.3	-	-	Bac_export_1
HKD1_k127_7482096_2	1120746.CCNL01000011_gene1487	4.649e-15	75.0	COG1987@1|root,COG1987@2|Bacteria,2NQ8H@2323|unclassified Bacteria	2|Bacteria	N	Bacterial export proteins, family 3	fliQ	-	-	ko:K02420	ko02040,map02040	-	-	-	ko00000,ko00001,ko02035,ko02044	3.A.6.2	-	-	Bac_export_3
HKD1_k127_7504656_0	445335.CBN_2215	3.566e-150	481.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1TPM6@1239|Firmicutes,247V1@186801|Clostridia,36EGZ@31979|Clostridiaceae	186801|Clostridia	C	NADH flavin oxidoreductase NADH oxidase	fldZ	-	1.3.1.31	ko:K10797	ko00360,ko01120,map00360,map01120	-	R02252	RC00669	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN,Pyr_redox_2
HKD1_k127_7506326_1	1410653.JHVC01000006_gene89	1.383e-109	362.0	COG1566@1|root,COG1566@2|Bacteria,1VE7A@1239|Firmicutes,25H0I@186801|Clostridia,36V70@31979|Clostridiaceae	186801|Clostridia	V	Outer membrane efflux protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,OEP
HKD1_k127_7506326_0	931276.Cspa_c50860	7.625e-159	506.0	COG0842@1|root,COG0842@2|Bacteria,1TQG7@1239|Firmicutes,249TT@186801|Clostridia,36ERZ@31979|Clostridiaceae	186801|Clostridia	V	ABC-type multidrug transport system, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane,ABC2_membrane_3
HKD1_k127_7506326_2	1410653.JHVC01000006_gene87	7.275e-30	118.0	COG1131@1|root,COG1131@2|Bacteria,1TQKM@1239|Firmicutes,25B35@186801|Clostridia,36IBW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7513509_1	666686.B1NLA3E_11125	2.132e-65	251.0	COG5401@1|root,COG5401@2|Bacteria,1TQX6@1239|Firmicutes,4HIBN@91061|Bacilli	91061|Bacilli	S	Sporulation and spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Germane
HKD1_k127_7513509_0	234267.Acid_7292	4.567e-152	510.0	COG1233@1|root,COG1233@2|Bacteria,3Y9B4@57723|Acidobacteria	57723|Acidobacteria	Q	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	FAD_oxidored
HKD1_k127_7513509_2	1507.HMPREF0262_00014	2.976e-05	46.0	COG3546@1|root,COG3546@2|Bacteria,1TQVQ@1239|Firmicutes,247YJ@186801|Clostridia,36EF7@31979|Clostridiaceae	186801|Clostridia	P	PFAM Manganese containing catalase	-	-	-	ko:K07217	-	-	-	-	ko00000	-	-	-	Mn_catalase
HKD1_k127_7520215_1	742766.HMPREF9455_01765	1.278e-58	205.0	COG1304@1|root,COG1304@2|Bacteria,4NKD6@976|Bacteroidetes,2FXIF@200643|Bacteroidia,23064@171551|Porphyromonadaceae	976|Bacteroidetes	C	FMN binding	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7520215_4	1304284.L21TH_1057	1.173e-37	146.0	COG1193@1|root,COG1193@2|Bacteria,1UHZ5@1239|Firmicutes,25E7T@186801|Clostridia,36V5J@31979|Clostridiaceae	186801|Clostridia	L	negative regulation of DNA recombination	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7520215_2	1128398.Curi_c16620	2.979e-46	171.0	COG0669@1|root,COG0669@2|Bacteria,1V3MR@1239|Firmicutes,24HC3@186801|Clostridia,2695J@186813|unclassified Clostridiales	186801|Clostridia	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD1_k127_7520215_3	1035196.HMPREF9998_00724	6.391e-42	160.0	COG0742@1|root,COG0742@2|Bacteria,1V3JF@1239|Firmicutes,24JHR@186801|Clostridia,25RB7@186804|Peptostreptococcaceae	186801|Clostridia	L	RNA methyltransferase, RsmD family	rsmD	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD1_k127_7520215_0	1128398.Curi_c16690	2.117e-129	421.0	COG1200@1|root,COG1200@2|Bacteria,1TQ6I@1239|Firmicutes,247T0@186801|Clostridia,267P4@186813|unclassified Clostridiales	186801|Clostridia	L	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD1_k127_7526198_1	1151292.QEW_1964	2.276e-27	112.0	COG0040@1|root,COG0040@2|Bacteria,1TSVZ@1239|Firmicutes,249AR@186801|Clostridia,25T18@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity	hisG	-	2.4.2.17	ko:K00765,ko:K02502	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01071	RC02819,RC03200	ko00000,ko00001,ko00002,ko01000	-	-	-	HisG
HKD1_k127_7526198_0	1410653.JHVC01000024_gene1137	1.157e-134	437.0	COG0141@1|root,COG0141@2|Bacteria,1TPAW@1239|Firmicutes,248X8@186801|Clostridia,36EFR@31979|Clostridiaceae	186801|Clostridia	E	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine	hisD	-	1.1.1.23	ko:K00013	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R01158,R01163,R03012	RC00099,RC00242,RC00463	ko00000,ko00001,ko00002,ko01000	-	-	-	Histidinol_dh
HKD1_k127_7527593_1	1347392.CCEZ01000049_gene1306	4.192e-23	104.0	COG0572@1|root,COG0572@2|Bacteria,1TQ4V@1239|Firmicutes,249IT@186801|Clostridia,36DT4@31979|Clostridiaceae	186801|Clostridia	F	uridine kinase	udk	-	2.7.1.48	ko:K00876	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R00513,R00516,R00517,R00962,R00964,R00967,R00968,R00970,R01548,R01549,R01880,R02091,R02096,R02097,R02327,R02332,R02371,R02372,R08232	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	PRK
HKD1_k127_7527593_0	1128398.Curi_c10690	3.504e-85	291.0	COG0564@1|root,COG0564@2|Bacteria,1TR1M@1239|Firmicutes,248W3@186801|Clostridia,267R6@186813|unclassified Clostridiales	186801|Clostridia	J	Responsible for synthesis of pseudouridine from uracil	rluC	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_7527850_0	913865.DOT_4503	1.916e-26	108.0	COG3666@1|root,COG3666@2|Bacteria,1TQQ9@1239|Firmicutes,24AG9@186801|Clostridia,26246@186807|Peptococcaceae	186801|Clostridia	L	PFAM Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD1_k127_7528983_2	1403313.AXBR01000021_gene2922	6.491e-105	344.0	COG4832@1|root,COG4832@2|Bacteria,1TQC2@1239|Firmicutes,4HH7M@91061|Bacilli,1ZHKI@1386|Bacillus	91061|Bacilli	S	GyrI-like small molecule binding domain	-	-	-	-	-	-	-	-	-	-	-	-	GyrI-like
HKD1_k127_7528983_0	1120998.AUFC01000006_gene890	1.362e-141	474.0	COG0840@1|root,COG5000@1|root,COG0840@2|Bacteria,COG5000@2|Bacteria,1TP5A@1239|Firmicutes,247S3@186801|Clostridia	186801|Clostridia	NT	methyl-accepting chemotaxis protein	-	-	-	-	-	-	-	-	-	-	-	-	HAMP,MCPsignal,dCache_1
HKD1_k127_7528983_1	857293.CAAU_0043	2.727e-109	358.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,36F13@31979|Clostridiaceae	186801|Clostridia	E	amino acid carrier protein	-	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
HKD1_k127_7530262_0	1408422.JHYF01000020_gene1821	6.927e-120	396.0	COG0517@1|root,COG0857@1|root,COG1227@1|root,COG0517@2|Bacteria,COG0857@2|Bacteria,COG1227@2|Bacteria,1TPH6@1239|Firmicutes,248RQ@186801|Clostridia,36DW2@31979|Clostridiaceae	186801|Clostridia	C	Inorganic pyrophosphatase	ppaC	-	3.6.1.1	ko:K15986	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	CBS,DHH,DHHA2,DRTGG
HKD1_k127_7530262_1	1120998.AUFC01000016_gene23	2.206e-69	239.0	COG1171@1|root,COG1171@2|Bacteria,1TP22@1239|Firmicutes,248D5@186801|Clostridia,3WCTC@538999|Clostridiales incertae sedis	186801|Clostridia	E	Pyridoxal-phosphate dependent enzyme	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
HKD1_k127_7530303_1	592015.HMPREF1705_02019	8.191e-61	213.0	COG1593@1|root,COG1593@2|Bacteria,3TA8I@508458|Synergistetes	508458|Synergistetes	G	PFAM TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7530303_2	891968.Anamo_1974	2.613e-40	154.0	COG3090@1|root,COG3090@2|Bacteria,3TB8X@508458|Synergistetes	508458|Synergistetes	G	PFAM Tripartite ATP-independent periplasmic transporter DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_7530303_0	584708.Apau_0215	1.038e-75	259.0	COG1638@1|root,COG1638@2|Bacteria,3TA9S@508458|Synergistetes	508458|Synergistetes	G	extracellular solute-binding protein, family 7	-	-	-	ko:K21395	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctP
HKD1_k127_7533040_0	693746.OBV_13640	7.526e-143	456.0	COG0207@1|root,COG0207@2|Bacteria,1TSIR@1239|Firmicutes,249QG@186801|Clostridia,2N6BA@216572|Oscillospiraceae	186801|Clostridia	F	Thymidylate synthase	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD1_k127_7533040_1	411461.DORFOR_00833	4.896e-47	175.0	COG0262@1|root,COG0262@2|Bacteria,1VB80@1239|Firmicutes,24FTH@186801|Clostridia,27VJG@189330|Dorea	186801|Clostridia	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD1_k127_7533060_0	457570.Nther_0338	5.236e-77	264.0	COG1763@1|root,COG1763@2|Bacteria,1V42Z@1239|Firmicutes,24IMW@186801|Clostridia	186801|Clostridia	H	molybdopterin-guanine dinucleotide biosynthesis	mobB	-	-	ko:K03753	-	-	-	-	ko00000	-	-	-	FeS,MobB
HKD1_k127_7533060_1	469618.FVAG_00675	1.249e-55	200.0	COG5423@1|root,COG5423@2|Bacteria,37BR5@32066|Fusobacteria	32066|Fusobacteria	S	Predicted metal-binding protein (DUF2284)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2284
HKD1_k127_7537450_2	1304284.L21TH_1525	3.67e-99	331.0	COG1173@1|root,COG1173@2|Bacteria,1TP4R@1239|Firmicutes,2489T@186801|Clostridia,36E1E@31979|Clostridiaceae	186801|Clostridia	EP	PFAM binding-protein-dependent transport systems inner membrane component	-	-	-	ko:K02034	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1,OppC_N,RCC1_2
HKD1_k127_7537450_1	1304284.L21TH_1526	1.087e-111	369.0	COG0601@1|root,COG0601@2|Bacteria,1TP1S@1239|Firmicutes,247IP@186801|Clostridia,36F10@31979|Clostridiaceae	186801|Clostridia	P	PFAM binding-protein-dependent transport systems inner membrane component	appB	-	-	ko:K02033	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	BPD_transp_1
HKD1_k127_7537450_0	1304284.L21TH_1527	8.316e-124	416.0	COG0747@1|root,COG0747@2|Bacteria,1TQ0N@1239|Firmicutes,25CDM@186801|Clostridia,36EUU@31979|Clostridiaceae	186801|Clostridia	E	family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_7538584_0	1121289.JHVL01000003_gene2251	9.33e-123	398.0	COG0541@1|root,COG0541@2|Bacteria,1TP06@1239|Firmicutes,248EU@186801|Clostridia,36E8W@31979|Clostridiaceae	186801|Clostridia	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD1_k127_7538584_1	350688.Clos_1462	2.254e-20	95.0	COG2739@1|root,COG2739@2|Bacteria,1VEGP@1239|Firmicutes,24QNM@186801|Clostridia,36MJ0@31979|Clostridiaceae	186801|Clostridia	S	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein	-	-	-	ko:K09787	-	-	-	-	ko00000	-	-	-	UPF0122
HKD1_k127_7542926_0	768706.Desor_4283	4.796e-114	381.0	COG1593@1|root,COG1593@2|Bacteria,1TPNU@1239|Firmicutes,248BY@186801|Clostridia,263NB@186807|Peptococcaceae	186801|Clostridia	G	transporter, DctM subunit	-	-	-	ko:K21393	-	-	-	-	ko00000,ko02000	2.A.56.1	-	-	DctM,DctQ
HKD1_k127_7542926_4	1499967.BAYZ01000184_gene4562	2.299e-19	94.0	COG3090@1|root,COG3090@2|Bacteria	2|Bacteria	G	Trap-type c4-dicarboxylate transport system, small permease component	-	-	-	ko:K11689,ko:K21394	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.56.1	-	-	DctQ
HKD1_k127_7542926_3	688269.Theth_0196	3.08e-63	230.0	COG1638@1|root,COG1638@2|Bacteria	2|Bacteria	G	carbohydrate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_7542926_1	358220.C380_23550	4.801e-74	259.0	COG1893@1|root,COG1893@2|Bacteria,1P0AW@1224|Proteobacteria,2VQ81@28216|Betaproteobacteria,4AE43@80864|Comamonadaceae	28216|Betaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD1_k127_7542926_2	411902.CLOBOL_06269	6.381e-65	226.0	COG1013@1|root,COG1013@2|Bacteria,1TPF0@1239|Firmicutes,24BE5@186801|Clostridia,222QN@1506553|Lachnoclostridium	186801|Clostridia	C	Thiamine pyrophosphate enzyme, C-terminal TPP binding domain	-	-	1.2.7.1	ko:K00170	ko00010,ko00020,ko00620,ko00633,ko00640,ko00650,ko00680,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00633,map00640,map00650,map00680,map00720,map01100,map01120,map01130,map01200	M00173,M00307,M00374,M00620	R01196,R01199,R08034	RC00004,RC00250,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD1_k127_7565751_1	221109.22777993	3.909e-38	149.0	COG2519@1|root,COG2519@2|Bacteria,1V6VU@1239|Firmicutes,4ISFT@91061|Bacilli,23KD4@182709|Oceanobacillus	91061|Bacilli	J	Putative rRNA methylase	ytqB	-	-	-	-	-	-	-	-	-	-	-	rRNA_methylase
HKD1_k127_7565751_0	279010.BL00662	1.814e-41	156.0	COG1187@1|root,COG1187@2|Bacteria,1TP68@1239|Firmicutes,4H9MU@91061|Bacilli,1ZBNQ@1386|Bacillus	91061|Bacilli	J	Belongs to the pseudouridine synthase RsuA family	rluB	GO:0000154,GO:0000455,GO:0001522,GO:0003674,GO:0003824,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006139,GO:0006364,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009451,GO:0009982,GO:0009987,GO:0010467,GO:0016070,GO:0016072,GO:0016853,GO:0016866,GO:0022613,GO:0031118,GO:0034470,GO:0034641,GO:0034660,GO:0042254,GO:0043170,GO:0043412,GO:0044085,GO:0044237,GO:0044238,GO:0044424,GO:0044444,GO:0044464,GO:0046483,GO:0071704,GO:0071840,GO:0090304,GO:1901360	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD1_k127_7566465_1	1120998.AUFC01000005_gene630	3.124e-133	428.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3WCY8@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_7566465_0	941824.TCEL_00477	1.506e-148	475.0	COG1115@1|root,COG1115@2|Bacteria,1TNZP@1239|Firmicutes,247S6@186801|Clostridia,36F13@31979|Clostridiaceae	186801|Clostridia	E	amino acid carrier protein	yrbD	-	-	ko:K03310	-	-	-	-	ko00000	2.A.25	-	-	Na_Ala_symp
HKD1_k127_7572171_2	350688.Clos_1201	3.347e-60	214.0	COG0577@1|root,COG0577@2|Bacteria,1TPUU@1239|Firmicutes,2483J@186801|Clostridia,36ETV@31979|Clostridiaceae	186801|Clostridia	V	ABC-type antimicrobial peptide transport system, permease component	macB1	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD1_k127_7572171_0	350688.Clos_1200	3.062e-100	331.0	COG1136@1|root,COG1136@2|Bacteria,1TPBJ@1239|Firmicutes,248EZ@186801|Clostridia,36DXW@31979|Clostridiaceae	186801|Clostridia	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD1_k127_7572171_1	350688.Clos_1199	8.498e-76	267.0	COG0845@1|root,COG0845@2|Bacteria,1V2JZ@1239|Firmicutes,24A5A@186801|Clostridia,36GVR@31979|Clostridiaceae	186801|Clostridia	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005,ko:K13888	-	M00709	-	-	ko00000,ko00002,ko02000	8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD1_k127_7572852_3	1408304.JAHA01000003_gene3198	4.593e-119	386.0	COG4992@1|root,COG4992@2|Bacteria,1TP9S@1239|Firmicutes,248C9@186801|Clostridia,4BXTE@830|Butyrivibrio	186801|Clostridia	E	Aminotransferase class-III	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD1_k127_7572852_2	1235802.C823_03932	1.484e-119	390.0	COG0548@1|root,COG0548@2|Bacteria,1TP0N@1239|Firmicutes,2486J@186801|Clostridia,25UYD@186806|Eubacteriaceae	186801|Clostridia	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.7.2.8	ko:K00930	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R02649	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase
HKD1_k127_7572852_1	1298920.KI911353_gene3808	1.211e-182	579.0	COG1364@1|root,COG1364@2|Bacteria,1TPBP@1239|Firmicutes,2497Q@186801|Clostridia,21YCZ@1506553|Lachnoclostridium	186801|Clostridia	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD1_k127_7572852_0	180332.JTGN01000007_gene3524	3.203e-184	580.0	COG0002@1|root,COG0002@2|Bacteria,1TPVI@1239|Firmicutes,247R3@186801|Clostridia	186801|Clostridia	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD1_k127_7573991_0	1304284.L21TH_0784	2.6e-309	953.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,36DSA@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_7575267_0	457396.CSBG_00871	2.218e-88	299.0	28K3V@1|root,2Z9SY@2|Bacteria,1V0NZ@1239|Firmicutes,24EEF@186801|Clostridia,36IDK@31979|Clostridiaceae	186801|Clostridia	S	EcsC protein family	-	-	-	-	-	-	-	-	-	-	-	-	EcsC
HKD1_k127_7575267_1	265311.Mfl050	3.58e-11	63.0	COG0225@1|root,COG0225@2|Bacteria,3WTJE@544448|Tenericutes	544448|Tenericutes	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11,1.8.4.12	ko:K07304,ko:K12267	-	-	-	-	ko00000,ko01000	-	-	-	PMSR,SelR
HKD1_k127_7576960_0	1031288.AXAA01000010_gene439	8.061e-177	557.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,36DQ3@31979|Clostridiaceae	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
HKD1_k127_7576960_1	997350.HMPREF9129_2122	8.957e-136	440.0	COG2235@1|root,COG2235@2|Bacteria,1TQWS@1239|Firmicutes,249V9@186801|Clostridia,22GMN@1570339|Peptoniphilaceae	186801|Clostridia	E	Arginine dihydrolase	arcA	-	3.5.3.6	ko:K01478	ko00220,ko01100,ko01110,ko01130,map00220,map01100,map01110,map01130	-	R00552	RC00177	ko00000,ko00001,ko01000	-	-	-	Amidinotransf
HKD1_k127_7583714_2	1123009.AUID01000004_gene1511	1.212e-51	184.0	COG4231@1|root,COG4231@2|Bacteria,1TNY3@1239|Firmicutes,247U1@186801|Clostridia,26A1D@186813|unclassified Clostridiales	186801|Clostridia	C	Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates	iorA	-	1.2.7.8	ko:K00179	-	-	-	-	br01601,ko00000,ko01000	-	-	-	Fer4,Fer4_10,Fer4_6,Fer4_9,POR_N,TPP_enzyme_C
HKD1_k127_7583714_1	768706.Desor_4408	4.905e-75	256.0	COG1014@1|root,COG1014@2|Bacteria,1V1DT@1239|Firmicutes,24HIC@186801|Clostridia,261U9@186807|Peptococcaceae	186801|Clostridia	C	PFAM pyruvate ferredoxin flavodoxin oxidoreductase	iorB	-	1.2.7.8	ko:K00180	-	-	-	-	br01601,ko00000,ko01000	-	-	-	POR
HKD1_k127_7583714_0	767817.Desgi_3981	8.164e-162	514.0	COG0043@1|root,COG0043@2|Bacteria,1TQ6V@1239|Firmicutes,248WY@186801|Clostridia,263XE@186807|Peptococcaceae	186801|Clostridia	H	TIGRFAM UbiD family decarboxylases	-	-	4.1.1.98	ko:K03182	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04985,R04986	RC00391	ko00000,ko00001,ko00002,ko01000	-	-	-	UbiD
HKD1_k127_7583838_1	720554.Clocl_4122	6.227e-46	167.0	COG0609@1|root,COG0609@2|Bacteria,1TPX6@1239|Firmicutes,248IS@186801|Clostridia,3WI3U@541000|Ruminococcaceae	186801|Clostridia	P	FecCD transport family	btuC	-	-	ko:K02015	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	FecCD
HKD1_k127_7583838_0	720554.Clocl_4121	9.544e-94	314.0	COG1120@1|root,COG1120@2|Bacteria,1TP2Q@1239|Firmicutes,25B89@186801|Clostridia,3WJQ3@541000|Ruminococcaceae	186801|Clostridia	HP	ATPases associated with a variety of cellular activities	fhuC	-	3.6.3.34	ko:K02013	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.14	-	-	ABC_tran
HKD1_k127_7583838_2	642492.Clole_3302	1.2e-19	89.0	COG2102@1|root,COG2102@2|Bacteria,1UAKZ@1239|Firmicutes,24C6P@186801|Clostridia	186801|Clostridia	S	Diphthamide synthase	-	-	-	-	-	-	-	-	-	-	-	-	Diphthami_syn_2
HKD1_k127_7594165_3	469617.FUAG_01027	1.528e-22	99.0	COG1032@1|root,COG1032@2|Bacteria,379FR@32066|Fusobacteria	32066|Fusobacteria	C	Radical SAM domain protein	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_7594165_1	642492.Clole_1306	9.151e-140	456.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_7594165_0	469617.FUAG_01030	1.2e-202	639.0	COG1032@1|root,COG1032@2|Bacteria,378KG@32066|Fusobacteria	32066|Fusobacteria	C	overlaps another CDS with the same product name	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,Radical_SAM
HKD1_k127_7594165_2	1121324.CLIT_2c02250	2.309e-60	213.0	COG1032@1|root,COG1032@2|Bacteria,1UYAF@1239|Firmicutes,24D1D@186801|Clostridia	186801|Clostridia	C	PFAM Radical SAM	-	-	-	-	-	-	-	-	-	-	-	-	B12-binding,DUF4070,Radical_SAM
HKD1_k127_7608593_0	445973.CLOBAR_02616	1.249e-149	486.0	COG3875@1|root,COG3875@2|Bacteria,1TQ1C@1239|Firmicutes,247PH@186801|Clostridia,25R07@186804|Peptostreptococcaceae	186801|Clostridia	S	Psort location Cytoplasmic, score 8.87	-	-	-	-	-	-	-	-	-	-	-	-	DUF2088
HKD1_k127_7620578_0	195103.CPF_2897	0.0	1473.0	COG0458@1|root,COG0458@2|Bacteria,1TPID@1239|Firmicutes,2498I@186801|Clostridia,36DIP@31979|Clostridiaceae	186801|Clostridia	F	Carbamoyl-phosphate synthetase ammonia chain	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD1_k127_7620578_1	293826.Amet_4211	3.421e-48	175.0	COG0505@1|root,COG0505@2|Bacteria,1TQ8N@1239|Firmicutes,247Q8@186801|Clostridia,36DTQ@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD1_k127_7630241_2	1151292.QEW_1967	1.729e-77	261.0	COG0118@1|root,COG0118@2|Bacteria,1TQT0@1239|Firmicutes,248SH@186801|Clostridia,25SVT@186804|Peptostreptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR	hisH	-	-	ko:K02501	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase
HKD1_k127_7630241_1	272563.CD630_15520	8.436e-97	321.0	COG0106@1|root,COG0106@2|Bacteria,1V1IR@1239|Firmicutes,24GBJ@186801|Clostridia,25SUK@186804|Peptostreptococcaceae	186801|Clostridia	E	Histidine biosynthesis protein	hisA	-	5.3.1.16	ko:K01814	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04640	RC00945	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_7630241_0	445973.CLOBAR_01646	7.447e-131	420.0	COG0107@1|root,COG0107@2|Bacteria,1TP0W@1239|Firmicutes,24900@186801|Clostridia,25SNM@186804|Peptostreptococcaceae	186801|Clostridia	E	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit	hisF	-	-	ko:K02500	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04558	RC00010,RC01190,RC01943	ko00000,ko00001,ko00002,ko01000	-	-	-	His_biosynth
HKD1_k127_7630241_3	1519464.HY22_00585	1.95e-18	86.0	COG0139@1|root,COG0139@2|Bacteria,1FE2H@1090|Chlorobi	1090|Chlorobi	F	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP	hisI	-	3.5.4.19	ko:K01496	ko00340,ko01100,ko01110,ko01230,map00340,map01100,map01110,map01230	M00026	R04037	RC01055	ko00000,ko00001,ko00002,ko01000	-	-	-	PRA-CH
HKD1_k127_7630480_1	871963.Desdi_1163	2.202e-59	209.0	COG2217@1|root,COG2217@2|Bacteria,1TP5S@1239|Firmicutes,247MW@186801|Clostridia,2608V@186807|Peptococcaceae	186801|Clostridia	P	ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.54	ko:K17686	ko01524,ko04016,map01524,map04016	-	R00086	RC00002	ko00000,ko00001,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD1_k127_7630480_2	1487921.DP68_18415	1.635e-36	140.0	COG1937@1|root,COG1937@2|Bacteria,1VDEQ@1239|Firmicutes,25N4B@186801|Clostridia,36KGD@31979|Clostridiaceae	186801|Clostridia	S	Metal-sensitive transcriptional repressor	-	-	-	ko:K21600	-	-	-	-	ko00000,ko03000	-	-	-	Trns_repr_metal
HKD1_k127_7630480_0	1487921.DP68_18420	2.853e-69	236.0	28M3X@1|root,2ZAHZ@2|Bacteria,1VAMQ@1239|Firmicutes,24EZ1@186801|Clostridia,36GGK@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7636171_1	1385513.N780_06885	7.516e-33	136.0	COG0670@1|root,COG0670@2|Bacteria,1V6RG@1239|Firmicutes,4HISH@91061|Bacilli,2YA7F@289201|Pontibacillus	91061|Bacilli	S	Belongs to the BI1 family	yetJ	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
HKD1_k127_7636171_0	1321778.HMPREF1982_02794	1.303e-77	267.0	COG1309@1|root,COG1309@2|Bacteria,1V8M2@1239|Firmicutes,24J7T@186801|Clostridia	186801|Clostridia	K	tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD1_k127_7650311_4	457396.CSBG_02286	1.14e-05	47.0	COG0725@1|root,COG0725@2|Bacteria,1U9U3@1239|Firmicutes,249VA@186801|Clostridia,36EBM@31979|Clostridiaceae	186801|Clostridia	P	ABC transporter, periplasmic molybdate-binding protein	modA	-	-	ko:K02020	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	iHN637.CLJU_RS12820	SBP_bac_11
HKD1_k127_7650311_1	1321778.HMPREF1982_00497	7.584e-101	332.0	COG4149@1|root,COG4149@2|Bacteria,1TRNA@1239|Firmicutes,24BR9@186801|Clostridia,269AN@186813|unclassified Clostridiales	186801|Clostridia	P	Binding-protein-dependent transport system inner membrane component	modB	-	-	ko:K02018	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.8	-	-	BPD_transp_1
HKD1_k127_7650311_0	457396.CSBG_02284	1.692e-162	517.0	COG1118@1|root,COG1118@2|Bacteria,1UI1E@1239|Firmicutes,25EAE@186801|Clostridia,36EU6@31979|Clostridiaceae	186801|Clostridia	P	the current gene model (or a revised gene model) may contain a frame shift	modC	-	3.6.3.29	ko:K02017	ko02010,map02010	M00189	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.8	-	-	ABC_tran
HKD1_k127_7650311_3	1408437.JNJN01000019_gene13	1.666e-14	78.0	COG2005@1|root,COG2005@2|Bacteria,1VFW6@1239|Firmicutes,24QTV@186801|Clostridia,25XEN@186806|Eubacteriaceae	186801|Clostridia	S	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	ko:K02019	-	-	-	-	ko00000,ko03000	-	-	-	HTH_1,NTP_transf_3
HKD1_k127_7650311_2	1304284.L21TH_1017	1.195e-71	250.0	28NR9@1|root,2ZBQJ@2|Bacteria,1UZEN@1239|Firmicutes,24G0V@186801|Clostridia,36I0Y@31979|Clostridiaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7651242_0	596323.HMPREF0554_1399	2.189e-143	462.0	COG0473@1|root,COG0473@2|Bacteria,37872@32066|Fusobacteria	32066|Fusobacteria	C	Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate	leuB	-	1.1.1.85	ko:K00052	ko00290,ko00660,ko01100,ko01110,ko01210,ko01230,map00290,map00660,map01100,map01110,map01210,map01230	M00432,M00535	R00994,R04426,R10052	RC00084,RC00417,RC03036	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD1_k127_7651242_1	1304284.L21TH_2680	1.855e-40	154.0	2ADZG@1|root,313RY@2|Bacteria,1V6JT@1239|Firmicutes,24FSH@186801|Clostridia,36I03@31979|Clostridiaceae	186801|Clostridia	S	Sporulation protein YyaC	yyaC	-	-	-	-	-	-	-	-	-	-	-	DUF1256
HKD1_k127_7670011_0	552396.HMPREF0863_01349	2.79e-141	462.0	COG0770@1|root,COG0770@2|Bacteria,1VT78@1239|Firmicutes,3VP1W@526524|Erysipelotrichia	526524|Erysipelotrichia	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD1_k127_7670011_1	552396.HMPREF0863_01348	2.874e-58	206.0	COG1181@1|root,COG1181@2|Bacteria,1TP2Y@1239|Firmicutes,3VPYC@526524|Erysipelotrichia	526524|Erysipelotrichia	F	Belongs to the D-alanine--D-alanine ligase family	ddl	-	-	-	-	-	-	-	-	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD1_k127_7678281_2	1031288.AXAA01000002_gene1408	4.125e-69	239.0	2BUSS@1|root,32Q45@2|Bacteria,1VUI1@1239|Firmicutes,25062@186801|Clostridia	186801|Clostridia	L	MjaI restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	RE_MjaI
HKD1_k127_7678281_0	1121335.Clst_1180	7.272e-122	401.0	COG0863@1|root,COG0863@2|Bacteria	2|Bacteria	L	N-4 methylation of cytosine	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD1_k127_7678281_4	1499680.CCFE01000011_gene821	1.442e-05	49.0	COG1476@1|root,COG1476@2|Bacteria,1UNRS@1239|Firmicutes,4IUMX@91061|Bacilli,1ZHHX@1386|Bacillus	91061|Bacilli	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD1_k127_7678281_3	1209989.TepiRe1_0271	2.271e-29	118.0	COG0864@1|root,COG0864@2|Bacteria,1VF9M@1239|Firmicutes,24QVJ@186801|Clostridia,42GWH@68295|Thermoanaerobacterales	186801|Clostridia	K	Iron-only hydrogenase system regulator	-	-	-	-	-	-	-	-	-	-	-	-	NikR_C
HKD1_k127_7678281_1	1511.CLOST_2280	4.29e-87	299.0	COG0715@1|root,COG0715@2|Bacteria,1TT2F@1239|Firmicutes,249M2@186801|Clostridia,25QJV@186804|Peptostreptococcaceae	186801|Clostridia	P	Menaquinone biosynthesis	-	-	-	ko:K02051	-	M00188	-	-	ko00000,ko00002,ko02000	3.A.1.16,3.A.1.17	-	-	NMT1,Phosphonate-bd,VitK2_biosynth
HKD1_k127_7680635_0	1476973.JMMB01000007_gene1645	3.643e-136	443.0	COG1454@1|root,COG1454@2|Bacteria,1TPB4@1239|Firmicutes,247IQ@186801|Clostridia,25T5E@186804|Peptostreptococcaceae	186801|Clostridia	C	Iron-containing alcohol dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Fe-ADH
HKD1_k127_7680635_1	411469.EUBHAL_03261	5.551e-66	235.0	COG4857@1|root,COG4857@2|Bacteria,1TPHY@1239|Firmicutes,249RB@186801|Clostridia,25VMG@186806|Eubacteriaceae	186801|Clostridia	H	Psort location Cytoplasmic, score 8.87	mtnK	-	2.7.1.100	ko:K00899	ko00270,ko01100,map00270,map01100	M00034	R04143	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	APH
HKD1_k127_7697384_0	1408422.JHYF01000003_gene817	8.969e-54	199.0	COG1074@1|root,COG1074@2|Bacteria,1TQ35@1239|Firmicutes,248ZF@186801|Clostridia,36E2W@31979|Clostridiaceae	186801|Clostridia	L	ATP-dependent helicase nuclease subunit A	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD1_k127_7697457_0	658088.HMPREF0987_02063	1.376e-148	475.0	COG3276@1|root,COG3276@2|Bacteria,1TPQS@1239|Firmicutes,2484U@186801|Clostridia,27KY2@186928|unclassified Lachnospiraceae	186801|Clostridia	J	Elongation factor SelB, winged helix	selB	-	-	ko:K03833	-	-	-	-	ko00000,ko03012	-	-	-	GTP_EFTU,GTP_EFTU_D2,SelB-wing_2,SelB-wing_3
HKD1_k127_7697457_1	272563.CD630_24950	1.149e-80	275.0	COG1921@1|root,COG1921@2|Bacteria,1TQT8@1239|Firmicutes,2498U@186801|Clostridia,25R1B@186804|Peptostreptococcaceae	186801|Clostridia	J	Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis	selA	-	2.9.1.1	ko:K01042	ko00450,ko00970,map00450,map00970	-	R08219	RC01246	ko00000,ko00001,ko01000	-	-	-	Se-cys_synth_N,SelA
HKD1_k127_7718445_0	1291050.JAGE01000001_gene3205	6.738e-227	706.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia,3WIAE@541000|Ruminococcaceae	186801|Clostridia	L	PFAM Transposase, Mutator	-	-	-	-	-	-	-	-	-	-	-	-	Transposase_mut
HKD1_k127_7718740_0	1499689.CCNN01000004_gene214	1.203e-90	301.0	COG0441@1|root,COG0441@2|Bacteria,1TP78@1239|Firmicutes,248CH@186801|Clostridia,36DPZ@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD1_k127_7718740_1	469616.FMAG_00106	8.689e-84	280.0	COG2820@1|root,COG2820@2|Bacteria,379GP@32066|Fusobacteria	32066|Fusobacteria	F	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis	udp	-	2.4.2.3	ko:K00757	ko00240,ko00983,ko01100,map00240,map00983,map01100	-	R01876,R02484,R08229	RC00063	ko00000,ko00001,ko01000	-	-	-	PNP_UDP_1
HKD1_k127_7721311_0	1128398.Curi_c07080	5.301e-81	273.0	COG0461@1|root,COG0461@2|Bacteria,1V1BZ@1239|Firmicutes,25CGM@186801|Clostridia,268PW@186813|unclassified Clostridiales	186801|Clostridia	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD1_k127_7721311_1	272563.CD630_01860	3.329e-36	138.0	COG0167@1|root,COG0167@2|Bacteria,1TPFV@1239|Firmicutes,248CQ@186801|Clostridia,25QCB@186804|Peptostreptococcaceae	186801|Clostridia	F	Catalyzes the conversion of dihydroorotate to orotate	pyrD	-	1.3.1.14	ko:K17828	ko00240,ko01100,map00240,map01100	M00051	R01869	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD1_k127_7726305_0	1347392.CCEZ01000049_gene1606	7.958e-76	255.0	COG0674@1|root,COG1013@1|root,COG1014@1|root,COG1143@1|root,COG0674@2|Bacteria,COG1013@2|Bacteria,COG1014@2|Bacteria,COG1143@2|Bacteria,1TQJ2@1239|Firmicutes,248FW@186801|Clostridia,36EA6@31979|Clostridiaceae	186801|Clostridia	C	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin	nifJ	-	1.2.7.1	ko:K03737	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00173,M00307	R01196,R10866	RC00004,RC02742	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	EKR,Fer4_16,Fer4_7,PFOR_II,POR,POR_N,TPP_enzyme_C
HKD1_k127_7726305_1	1128398.Curi_c20340	3.594e-45	166.0	COG1493@1|root,COG1493@2|Bacteria,1TP5Z@1239|Firmicutes,24999@186801|Clostridia,26815@186813|unclassified Clostridiales	186801|Clostridia	T	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion	hprK	-	-	ko:K06023	-	-	-	-	ko00000,ko01000	-	-	-	Hpr_kinase_C,Hpr_kinase_N
HKD1_k127_7729093_1	332101.JIBU02000012_gene889	1.118e-44	169.0	COG3758@1|root,COG3758@2|Bacteria,1VH52@1239|Firmicutes,24P8J@186801|Clostridia,36ECZ@31979|Clostridiaceae	186801|Clostridia	S	HutD	-	-	-	-	-	-	-	-	-	-	-	-	HutD
HKD1_k127_7729093_0	1499689.CCNN01000004_gene192	1.503e-61	214.0	COG0540@1|root,COG0540@2|Bacteria,1TQ96@1239|Firmicutes,2496D@186801|Clostridia,36DT0@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N,PyrI_C
HKD1_k127_773359_0	1304284.L21TH_0025	4.258e-181	574.0	COG1109@1|root,COG1109@2|Bacteria,1TP1X@1239|Firmicutes,2499P@186801|Clostridia,36DMU@31979|Clostridiaceae	186801|Clostridia	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD1_k127_773359_1	509191.AEDB02000002_gene1164	5.907e-76	259.0	COG1897@1|root,COG1897@2|Bacteria,1TQVR@1239|Firmicutes,247NP@186801|Clostridia,3WGY0@541000|Ruminococcaceae	186801|Clostridia	E	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine	metAA	-	2.3.1.46	ko:K00651	ko00270,ko00920,ko01100,ko01110,ko01230,map00270,map00920,map01100,map01110,map01230	M00017	R01777	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,HTS
HKD1_k127_7755984_0	1408422.JHYF01000004_gene1537	1.703e-241	759.0	COG1053@1|root,COG3976@1|root,COG1053@2|Bacteria,COG3976@2|Bacteria,1TPAR@1239|Firmicutes,247SY@186801|Clostridia,36DR3@31979|Clostridiaceae	186801|Clostridia	C	PFAM fumarate reductase succinate dehydrogenase flavoprotein domain protein	-	-	1.3.5.1,1.3.5.4,1.3.99.33	ko:K00239,ko:K00244,ko:K17363	ko00020,ko00190,ko00340,ko00620,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko02020,ko05134,map00020,map00190,map00340,map00620,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map02020,map05134	M00009,M00011,M00149,M00150,M00173,M00374,M00376	R02164,R10330	RC00045,RC00669	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,FMN_bind
HKD1_k127_7755984_2	411467.BACCAP_01371	1.061e-20	96.0	COG5341@1|root,COG5341@2|Bacteria,1UG2F@1239|Firmicutes,25N7J@186801|Clostridia,26C7V@186813|unclassified Clostridiales	186801|Clostridia	S	NusG domain II	-	-	-	-	-	-	-	-	-	-	-	-	NusG_II
HKD1_k127_7755984_1	411467.BACCAP_01370	2.114e-43	163.0	COG4769@1|root,COG4769@2|Bacteria,1V1M0@1239|Firmicutes,24MZC@186801|Clostridia,269J7@186813|unclassified Clostridiales	186801|Clostridia	S	Heptaprenyl diphosphate synthase component I	-	-	2.5.1.30	ko:K00805	ko00900,ko01110,map00900,map01110	-	R09247	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	Hpre_diP_synt_I
HKD1_k127_7756222_0	350688.Clos_1523	4.705e-81	284.0	COG2176@1|root,COG2176@2|Bacteria,1TPAG@1239|Firmicutes,248YB@186801|Clostridia,36DEW@31979|Clostridiaceae	186801|Clostridia	L	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity	polC	-	2.7.7.7	ko:K02342,ko:K03763	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_a_NI,DNA_pol3_a_NII,DNA_pol3_alpha,HHH_6,PHP,RNase_T,tRNA_anti-codon
HKD1_k127_7808011_0	1231190.NA8A_19013	1.479e-60	219.0	COG1638@1|root,COG1638@2|Bacteria,1MVHC@1224|Proteobacteria,2TRZE@28211|Alphaproteobacteria,43H9N@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	Bacterial extracellular solute-binding protein, family 7	-	-	-	-	-	-	-	-	-	-	-	-	DctP
HKD1_k127_7808011_1	1256908.HMPREF0373_03220	1.087e-17	89.0	COG3090@1|root,COG3090@2|Bacteria,1TUP1@1239|Firmicutes,24X88@186801|Clostridia	186801|Clostridia	G	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD1_k127_7808011_2	298386.PBPRB1728	0.0004424	45.0	COG1593@1|root,COG1593@2|Bacteria,1MU0F@1224|Proteobacteria,1RNAM@1236|Gammaproteobacteria,1XTIW@135623|Vibrionales	135623|Vibrionales	G	TRAP-type C4-dicarboxylate transport system, large permease component	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD1_k127_7811118_0	994573.T472_0209345	5.21e-213	666.0	COG3845@1|root,COG3845@2|Bacteria,1UYQA@1239|Firmicutes,24XN8@186801|Clostridia,36UI0@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	3.6.3.17	ko:K02056	-	M00221	-	-	ko00000,ko00002,ko01000,ko02000	3.A.1.2	-	-	ABC_tran
HKD1_k127_7811118_1	994573.T472_0209340	1.98e-185	584.0	COG4603@1|root,COG4603@2|Bacteria,1TP1F@1239|Firmicutes,2494C@186801|Clostridia,36EKF@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	tsgB13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_7811118_2	994573.T472_0209335	1.914e-167	529.0	COG1079@1|root,COG1079@2|Bacteria,1TP8Y@1239|Firmicutes,2486N@186801|Clostridia,36EJH@31979|Clostridiaceae	186801|Clostridia	S	Belongs to the binding-protein-dependent transport system permease family	tsgC13	-	-	ko:K02057	-	M00221	-	-	ko00000,ko00002,ko02000	3.A.1.2	-	-	BPD_transp_2
HKD1_k127_7811118_3	1131462.DCF50_p1977	2.419e-12	70.0	COG2508@1|root,COG2508@2|Bacteria,1TTA0@1239|Firmicutes,248HN@186801|Clostridia,26320@186807|Peptococcaceae	186801|Clostridia	QT	PucR C-terminal helix-turn-helix domain	-	-	-	ko:K09684	-	-	-	-	ko00000,ko03000	-	-	-	HTH_30,PucR,V4R,XylR_N
HKD1_k127_7816133_1	536233.CLO_0668	1.08e-61	214.0	COG0716@1|root,COG0716@2|Bacteria,1UIMW@1239|Firmicutes,24JUW@186801|Clostridia,36KDG@31979|Clostridiaceae	186801|Clostridia	C	Flavodoxin	-	-	1.6.5.2	ko:K03809	ko00130,ko01110,map00130,map01110	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	FMN_red,Flavodoxin_1
HKD1_k127_7816133_0	290402.Cbei_1859	1.736e-162	514.0	COG1028@1|root,COG1028@2|Bacteria,1TR53@1239|Firmicutes,247XS@186801|Clostridia,36E9K@31979|Clostridiaceae	186801|Clostridia	IQ	Dehydrogenase	ydaD	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD1_k127_7816133_2	1196322.A370_02120	2.588e-17	81.0	COG1307@1|root,COG1307@2|Bacteria,1TYCV@1239|Firmicutes,248JV@186801|Clostridia,36E37@31979|Clostridiaceae	186801|Clostridia	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_7821192_0	545243.BAEV01000002_gene3273	3.13e-133	429.0	COG0420@1|root,COG0420@2|Bacteria,1TQY6@1239|Firmicutes,248VE@186801|Clostridia,36ED8@31979|Clostridiaceae	186801|Clostridia	L	SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'- 5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity	sbcD	-	-	ko:K03547	-	-	-	-	ko00000,ko03400	-	-	-	Metallophos,SbcD_C
HKD1_k127_7821192_1	537007.BLAHAN_04726	2.293e-57	208.0	COG0419@1|root,COG0419@2|Bacteria,1TPCS@1239|Firmicutes,24A22@186801|Clostridia,3XZKX@572511|Blautia	186801|Clostridia	L	Psort location	sbcC	-	-	ko:K03546	-	-	-	-	ko00000,ko03400	-	-	-	AAA_23,AAA_29,SbcCD_C
HKD1_k127_7822624_1	1120746.CCNL01000011_gene1502	6.061e-54	194.0	COG0835@1|root,COG0835@2|Bacteria	2|Bacteria	NT	chemotaxis	cheW2	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD1_k127_7822624_2	658086.HMPREF0994_00542	4.159e-23	104.0	2E455@1|root,32Z17@2|Bacteria,1VGDK@1239|Firmicutes	1239|Firmicutes	S	Late competence development protein ComFB	-	-	-	-	-	-	-	-	-	-	-	-	ComFB
HKD1_k127_7822624_0	1120746.CCNL01000017_gene2425	1.043e-101	336.0	COG1192@1|root,COG1192@2|Bacteria	2|Bacteria	D	plasmid maintenance	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD1_k127_7828581_2	545696.HOLDEFILI_00549	1.651e-27	117.0	COG1053@1|root,COG1053@2|Bacteria,1TSSJ@1239|Firmicutes,3VUFX@526524|Erysipelotrichia	526524|Erysipelotrichia	C	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_2,FMN_bind
HKD1_k127_7828581_0	555088.DealDRAFT_2531	5.705e-75	258.0	COG2197@1|root,COG2197@2|Bacteria,1TQ1U@1239|Firmicutes,24G53@186801|Clostridia,42JVS@68298|Syntrophomonadaceae	186801|Clostridia	K	PFAM regulatory protein LuxR	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD1_k127_7828581_1	555088.DealDRAFT_2530	6.958e-64	225.0	COG4585@1|root,COG4585@2|Bacteria,1V8KW@1239|Firmicutes,24F76@186801|Clostridia	2|Bacteria	T	Integral membrane sensor signal transduction histidine kinase	salK	-	2.7.13.3	ko:K07680,ko:K07778,ko:K11617,ko:K14988	ko02020,ko02024,map02020,map02024	M00476,M00479,M00481,M00522,M00754	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	7TMR-DISM_7TM,HATPase_c,HisKA_3,Response_reg
HKD1_k127_7834975_0	457415.HMPREF1006_00697	2.604e-106	353.0	COG0542@1|root,COG0542@2|Bacteria	2|Bacteria	O	response to heat	-	-	-	ko:K03694,ko:K03696	ko01100,map01100	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small
HKD1_k127_7834975_1	536227.CcarbDRAFT_3232	3.925e-70	252.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,PAS,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_7847433_1	469617.FUAG_02153	1.144e-53	192.0	COG0527@1|root,COG0527@2|Bacteria,37857@32066|Fusobacteria	32066|Fusobacteria	E	Belongs to the aspartokinase family	-	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD1_k127_7847433_2	1499689.CCNN01000007_gene1201	9.241e-46	171.0	COG4843@1|root,COG4843@2|Bacteria,1V14J@1239|Firmicutes,24J7S@186801|Clostridia,36IGD@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterized protein conserved in bacteria (DUF2179)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2179
HKD1_k127_7847433_0	1304284.L21TH_0314	1.458e-63	224.0	COG0220@1|root,COG0220@2|Bacteria,1TQCA@1239|Firmicutes,248YR@186801|Clostridia,36DWU@31979|Clostridiaceae	186801|Clostridia	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD1_k127_7847433_3	545697.HMPREF0216_03423	3.183e-08	56.0	COG3326@1|root,COG3326@2|Bacteria,1VEJY@1239|Firmicutes,24QJW@186801|Clostridia,36MRK@31979|Clostridiaceae	186801|Clostridia	S	Protein of unknown function (DUF1294)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1294
HKD1_k127_7850708_1	1321778.HMPREF1982_02931	2.254e-46	168.0	COG1132@1|root,COG1132@2|Bacteria,1TPTK@1239|Firmicutes,249W7@186801|Clostridia	186801|Clostridia	V	Psort location CytoplasmicMembrane, score 10.00	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD1_k127_7850708_0	1128398.Curi_c05620	1.786e-189	601.0	COG0534@1|root,COG0534@2|Bacteria,1TPFM@1239|Firmicutes,247J9@186801|Clostridia,267U4@186813|unclassified Clostridiales	186801|Clostridia	V	Polysaccharide biosynthesis C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD1_k127_7850708_2	871968.DESME_05065	3.073e-44	162.0	COG4430@1|root,COG4430@2|Bacteria,1VA6D@1239|Firmicutes,24N9F@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905,OmdA
HKD1_k127_7850708_3	742735.HMPREF9467_03206	3.394e-06	49.0	COG2388@1|root,COG2388@2|Bacteria,1VEEX@1239|Firmicutes,24RI0@186801|Clostridia,220X3@1506553|Lachnoclostridium	186801|Clostridia	S	GCN5-related N-acetyl-transferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
HKD1_k127_7859443_0	748727.CLJU_c24640	3.555e-79	276.0	COG0480@1|root,COG0480@2|Bacteria,1TPQH@1239|Firmicutes,247X4@186801|Clostridia,36DHY@31979|Clostridiaceae	186801|Clostridia	J	elongation factor G	tetP	-	-	-	-	-	-	-	-	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,NYN_YacP
HKD1_k127_7863174_0	871968.DESME_04040	3.553e-109	361.0	COG0614@1|root,COG0614@2|Bacteria,1TQ11@1239|Firmicutes,2482R@186801|Clostridia	186801|Clostridia	P	Periplasmic binding protein	-	-	-	ko:K02016	ko02010,map02010	M00240	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.14	-	-	Peripla_BP_2
HKD1_k127_7863174_1	871968.DESME_04045	3.883e-70	245.0	COG1571@1|root,COG1571@2|Bacteria,1V2YE@1239|Firmicutes,24N2W@186801|Clostridia	186801|Clostridia	S	tRNA wobble cytosine modification	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7863174_2	931276.Cspa_c50390	9.362e-41	152.0	COG4565@1|root,COG4565@2|Bacteria,1V49R@1239|Firmicutes,24BJS@186801|Clostridia,36HG7@31979|Clostridiaceae	186801|Clostridia	KT	transcriptional regulatory protein	-	-	-	ko:K02475,ko:K11615,ko:K11692,ko:K11712	ko02020,map02020	M00489,M00490	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_11,HTH_DeoR,HTH_IclR,Response_reg
HKD1_k127_7868547_2	1226325.HMPREF1548_06994	3.489e-16	85.0	COG0747@1|root,COG0747@2|Bacteria,1TQ6S@1239|Firmicutes,248A3@186801|Clostridia,36WU1@31979|Clostridiaceae	186801|Clostridia	E	Extracellular solute-binding protein, family 5	-	-	-	ko:K02035	ko02024,map02024	M00239	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.5	-	-	SBP_bac_5
HKD1_k127_7868547_1	1449335.JQLG01000004_gene620	1.003e-56	200.0	COG0824@1|root,COG0824@2|Bacteria,1VAGM@1239|Firmicutes,4HIVC@91061|Bacilli,27GE5@186828|Carnobacteriaceae	91061|Bacilli	S	Thioesterase-like superfamily	yneP	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD1_k127_7868547_0	1121289.JHVL01000004_gene2139	6.996e-67	237.0	COG1752@1|root,COG1752@2|Bacteria,1UBYN@1239|Firmicutes,247V3@186801|Clostridia,36WRU@31979|Clostridiaceae	186801|Clostridia	S	Patatin-like phospholipase	-	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	Patatin
HKD1_k127_7869088_1	332101.JIBU02000004_gene180	1.011e-42	159.0	COG2896@1|root,COG2896@2|Bacteria,1TP89@1239|Firmicutes,247PP@186801|Clostridia,36EQA@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate	moaA	-	4.1.99.22	ko:K03639	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R09394	RC03420	ko00000,ko00001,ko01000	-	-	-	Fer4_12,Fer4_14,Mob_synth_C,Radical_SAM
HKD1_k127_7869088_0	2325.TKV_c18670	1.404e-73	250.0	COG0315@1|root,COG0315@2|Bacteria,1V3J4@1239|Firmicutes,24H9F@186801|Clostridia,42GMY@68295|Thermoanaerobacterales	186801|Clostridia	H	Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP)	moaC	-	4.6.1.17	ko:K03637	ko00790,ko01100,ko04122,map00790,map01100,map04122	-	R11372	RC03425	ko00000,ko00001,ko01000	-	-	-	MoaC
HKD1_k127_7869088_2	340099.Teth39_0863	4.487e-05	45.0	COG2258@1|root,COG2258@2|Bacteria,1V6DS@1239|Firmicutes,24HBA@186801|Clostridia,42GFF@68295|Thermoanaerobacterales	186801|Clostridia	S	MOSC domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	MOSC
HKD1_k127_7878598_1	401526.TcarDRAFT_1522	9.49e-137	443.0	COG4666@1|root,COG4666@2|Bacteria,1TP0V@1239|Firmicutes,4H3FG@909932|Negativicutes	909932|Negativicutes	S	TRAP transporter, 4TM 12TM fusion protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3394,DctM
HKD1_k127_7878598_2	1415774.U728_628	1.124e-44	164.0	COG0607@1|root,COG0607@2|Bacteria,1UV62@1239|Firmicutes,24K2F@186801|Clostridia,36JTP@31979|Clostridiaceae	186801|Clostridia	P	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD1_k127_7878598_0	931276.Cspa_c28610	1.311e-303	937.0	COG0446@1|root,COG0607@1|root,COG0446@2|Bacteria,COG0607@2|Bacteria,1TPWW@1239|Firmicutes,2484C@186801|Clostridia,36DJA@31979|Clostridiaceae	186801|Clostridia	P	Belongs to the sulfur carrier protein TusA family	-	-	-	-	-	-	-	-	-	-	-	-	Pyr_redox_2,Pyr_redox_dim,Rhodanese
HKD1_k127_7914811_0	1120998.AUFC01000006_gene914	0.0	1229.0	COG1038@1|root,COG1038@2|Bacteria,1UHP9@1239|Firmicutes,25E5B@186801|Clostridia,3WCX3@538999|Clostridiales incertae sedis	186801|Clostridia	C	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second	pyc	-	6.4.1.1	ko:K01958	ko00020,ko00620,ko00720,ko01100,ko01120,ko01200,ko01230,map00020,map00620,map00720,map01100,map01120,map01200,map01230	M00173	R00344	RC00040,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS18410	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2,HMGL-like,PYC_OADA
HKD1_k127_7936171_2	1121335.Clst_1702	0.0005102	43.0	COG0004@1|root,COG0347@1|root,COG0004@2|Bacteria,COG0347@2|Bacteria,1TQYG@1239|Firmicutes,247W1@186801|Clostridia,3WH0N@541000|Ruminococcaceae	186801|Clostridia	P	Belongs to the P(II) protein family	amt	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp,P-II
HKD1_k127_7936171_1	350688.Clos_0173	3.416e-127	423.0	COG0665@1|root,COG0723@1|root,COG0665@2|Bacteria,COG0723@2|Bacteria,1TR1R@1239|Firmicutes,24A67@186801|Clostridia,36EHR@31979|Clostridiaceae	186801|Clostridia	CE	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO,Rieske
HKD1_k127_7936171_0	1304284.L21TH_0784	7.695e-254	788.0	COG0060@1|root,COG0060@2|Bacteria,1TPS7@1239|Firmicutes,247XX@186801|Clostridia,36DSA@31979|Clostridiaceae	186801|Clostridia	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1
HKD1_k127_7944945_0	768706.Desor_1618	1.372e-90	301.0	COG0531@1|root,COG0531@2|Bacteria,1TQ4K@1239|Firmicutes,249RJ@186801|Clostridia,267C5@186807|Peptococcaceae	186801|Clostridia	E	PFAM Amino acid	-	-	-	ko:K16238	-	-	-	-	ko00000,ko02000	2.A.3.5	-	-	AA_permease,AA_permease_2
HKD1_k127_7944945_1	1105031.HMPREF1141_0774	4.817e-22	99.0	COG2079@1|root,COG2079@2|Bacteria,1TSD7@1239|Firmicutes,24BFZ@186801|Clostridia	186801|Clostridia	S	MmgE PrpD family protein	-	-	-	-	-	-	-	-	-	-	-	-	MmgE_PrpD
HKD1_k127_7951181_2	1007096.BAGW01000023_gene243	2.048e-81	274.0	COG0684@1|root,COG0684@2|Bacteria,1V1ME@1239|Firmicutes,24E8B@186801|Clostridia,2N7EH@216572|Oscillospiraceae	186801|Clostridia	H	Aldolase/RraA	-	-	-	-	-	-	-	-	-	-	-	-	RraA-like
HKD1_k127_7951181_1	1226322.HMPREF1545_03356	9.781e-87	298.0	COG2055@1|root,COG2055@2|Bacteria,1TR0Z@1239|Firmicutes,247W5@186801|Clostridia,2N7JY@216572|Oscillospiraceae	186801|Clostridia	C	Malate/L-lactate dehydrogenase	mdh	-	-	-	-	-	-	-	-	-	-	-	Ldh_2
HKD1_k127_7951181_4	717605.Theco_3634	1.704e-20	96.0	29Z1W@1|root,30KZ9@2|Bacteria,1U4SZ@1239|Firmicutes,4IBH1@91061|Bacilli,270F0@186822|Paenibacillaceae	91061|Bacilli	S	Tripartite tricarboxylate transporter TctB family	-	-	-	-	-	-	-	-	-	-	-	-	TctB
HKD1_k127_7951181_0	1117379.BABA_03239	2.384e-142	467.0	COG3333@1|root,COG3333@2|Bacteria,1TPE7@1239|Firmicutes,4HADN@91061|Bacilli,1ZBVK@1386|Bacillus	91061|Bacilli	S	Tripartite tricarboxylate transporter TctA family	-	-	-	ko:K07793	ko02020,map02020	-	-	-	ko00000,ko00001,ko02000	2.A.80.1	-	-	TctA
HKD1_k127_7951181_3	742740.HMPREF9474_02621	4.691e-42	158.0	COG2084@1|root,COG2084@2|Bacteria,1V4MC@1239|Firmicutes,24KB8@186801|Clostridia	186801|Clostridia	I	Domain of unknown function (DUF1932)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1932,NAD_binding_2
HKD1_k127_7964276_0	272562.CA_C3416	8.456e-125	406.0	28NEG@1|root,320U5@2|Bacteria,1V2CD@1239|Firmicutes,24PY8@186801|Clostridia,36JV2@31979|Clostridiaceae	186801|Clostridia	S	Staygreen protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3888,Staygreen
HKD1_k127_7964276_1	1345695.CLSA_c21300	5.626e-95	320.0	COG1893@1|root,COG1893@2|Bacteria,1TSZ1@1239|Firmicutes,249UK@186801|Clostridia,36VH8@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C,Oxidored_FMN
HKD1_k127_7964276_2	1128398.Curi_c07730	1.986e-50	181.0	COG0599@1|root,COG0599@2|Bacteria,1VD58@1239|Firmicutes,24Q09@186801|Clostridia,26BPP@186813|unclassified Clostridiales	186801|Clostridia	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD1_k127_7964276_3	1120998.AUFC01000016_gene71	2.686e-40	153.0	2AIN5@1|root,3194H@2|Bacteria,1V6U3@1239|Firmicutes,24JK0@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF3842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3842
HKD1_k127_7973340_0	335541.Swol_1380	1.315e-107	370.0	COG1835@1|root,COG1835@2|Bacteria,1V0J2@1239|Firmicutes,247YD@186801|Clostridia,42KQZ@68298|Syntrophomonadaceae	186801|Clostridia	I	Domain of unknown function (DUF4153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4153
HKD1_k127_7973340_2	1243664.CAVL020000057_gene3170	4.447e-57	205.0	COG0586@1|root,COG0586@2|Bacteria,1TS2R@1239|Firmicutes,4HA51@91061|Bacilli,1ZQ9I@1386|Bacillus	91061|Bacilli	S	SNARE associated Golgi protein	apl	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	SNARE_assoc
HKD1_k127_7973340_3	509191.AEDB02000078_gene1399	4.608e-54	196.0	COG4275@1|root,COG4275@2|Bacteria,1V6T7@1239|Firmicutes,24KB9@186801|Clostridia,3WMS2@541000|Ruminococcaceae	186801|Clostridia	S	Chromate resistance exported protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_7973340_1	1449050.JNLE01000005_gene4119	4.148e-93	311.0	COG1307@1|root,COG1307@2|Bacteria,1TQDI@1239|Firmicutes,24ADT@186801|Clostridia,36EZJ@31979|Clostridiaceae	186801|Clostridia	S	DegV family	-	-	-	-	-	-	-	-	-	-	-	-	DegV
HKD1_k127_7981614_1	1321778.HMPREF1982_03634	1.043e-90	308.0	2C69W@1|root,2Z7HR@2|Bacteria,1TQNN@1239|Firmicutes,249G5@186801|Clostridia	186801|Clostridia	S	Domain of unknown function (DUF4474)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4474
HKD1_k127_7981614_0	1321778.HMPREF1982_03633	1.438e-132	428.0	COG2908@1|root,COG2908@2|Bacteria,1TT6N@1239|Firmicutes,24A8X@186801|Clostridia	186801|Clostridia	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD1_k127_7989449_1	411902.CLOBOL_06423	1.514e-76	261.0	COG2362@1|root,COG2362@2|Bacteria,1TSUZ@1239|Firmicutes,24CY1@186801|Clostridia,22291@1506553|Lachnoclostridium	186801|Clostridia	E	D-aminopeptidase	-	-	-	ko:K16203	-	-	-	-	ko00000,ko01000,ko01002	3.A.1.5.2	-	-	Peptidase_M55
HKD1_k127_7989449_0	1280689.AUJC01000010_gene1805	1.911e-229	724.0	COG1001@1|root,COG1001@2|Bacteria,1TP84@1239|Firmicutes,247KN@186801|Clostridia,36DDA@31979|Clostridiaceae	186801|Clostridia	F	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family	ade	-	3.5.4.2	ko:K01486	ko00230,ko01100,map00230,map01100	-	R01244	RC00477	ko00000,ko00001,ko01000	-	-	-	Adenine_deam_C,Amidohydro_1
HKD1_k127_799047_1	44251.PDUR_23035	2.068e-05	48.0	COG1388@1|root,COG1388@2|Bacteria,1V4FC@1239|Firmicutes,4HH96@91061|Bacilli,275T1@186822|Paenibacillaceae	91061|Bacilli	M	Acetylglutamate kinase	-	-	-	-	-	-	-	-	-	-	-	-	LysM
HKD1_k127_799047_0	1033810.HLPCO_001712	1.7e-124	404.0	COG0405@1|root,COG0405@2|Bacteria,2NP14@2323|unclassified Bacteria	2|Bacteria	E	Gamma-glutamyltranspeptidase	ggtA	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0006082,GO:0006508,GO:0006520,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008238,GO:0008242,GO:0008652,GO:0009058,GO:0009987,GO:0016053,GO:0016787,GO:0019538,GO:0019752,GO:0030288,GO:0030313,GO:0031975,GO:0034722,GO:0036374,GO:0042597,GO:0043094,GO:0043102,GO:0043170,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044281,GO:0044283,GO:0044464,GO:0046394,GO:0070011,GO:0071704,GO:0097264,GO:0140096,GO:1901564,GO:1901566,GO:1901576	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD1_k127_7992586_0	332101.JIBU02000001_gene4330	5.41e-247	777.0	COG3829@1|root,COG3829@2|Bacteria,1TP0E@1239|Firmicutes,247MB@186801|Clostridia,36DY7@31979|Clostridiaceae	186801|Clostridia	KT	PFAM sigma-54 factor interaction domain-containing protein	-	-	-	ko:K02688	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,PAS,PAS_4,PAS_8,PAS_9,PrpR_N,Sigma54_activat
HKD1_k127_7992586_2	1460634.JCM19037_2096	8.419e-94	322.0	COG2610@1|root,COG2610@2|Bacteria,1TQJ6@1239|Firmicutes,4HA01@91061|Bacilli	91061|Bacilli	EG	COG2610 H gluconate symporter and related permeases	XK27_05475	-	-	-	-	-	-	-	-	-	-	-	GntP_permease
HKD1_k127_7992586_1	469617.FUAG_01160	6.972e-101	330.0	COG1250@1|root,COG1250@2|Bacteria,3797U@32066|Fusobacteria	32066|Fusobacteria	I	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain	-	-	1.1.1.157	ko:K00074	ko00360,ko00362,ko00650,ko01100,ko01120,map00360,map00362,map00650,map01100,map01120	-	R01976,R05576,R06941	RC00029,RC00117	ko00000,ko00001,ko01000	-	-	-	3HCDH,3HCDH_N
HKD1_k127_8002512_2	1128398.Curi_c09430	2.726e-47	174.0	COG1104@1|root,COG1104@2|Bacteria,1TP21@1239|Firmicutes,24888@186801|Clostridia,267TY@186813|unclassified Clostridiales	186801|Clostridia	E	Aminotransferase class-V	iscS	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD1_k127_8002512_0	1304284.L21TH_2041	2.405e-137	447.0	COG0301@1|root,COG0301@2|Bacteria,1TPNW@1239|Firmicutes,247Y5@186801|Clostridia,36DP3@31979|Clostridiaceae	186801|Clostridia	H	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS	thiI	-	2.8.1.4	ko:K03151	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07461	-	ko00000,ko00001,ko01000,ko03016	-	-	-	THUMP,ThiI
HKD1_k127_8002512_1	1120998.AUFC01000029_gene189	5.653e-53	192.0	COG0111@1|root,COG0111@2|Bacteria,1V410@1239|Firmicutes,248H9@186801|Clostridia,3WDG2@538999|Clostridiales incertae sedis	186801|Clostridia	EH	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain	pdxB	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C
HKD1_k127_8005189_0	931276.Cspa_c52940	2.391e-173	544.0	COG1082@1|root,COG1082@2|Bacteria,1TT50@1239|Firmicutes,248RM@186801|Clostridia,36F79@31979|Clostridiaceae	186801|Clostridia	G	Xylose isomerase-like TIM barrel	-	-	-	-	-	-	-	-	-	-	-	-	AP_endonuc_2
HKD1_k127_8005189_1	411471.SUBVAR_05876	1.305e-13	71.0	COG1453@1|root,COG1453@2|Bacteria,1TSTA@1239|Firmicutes,249IP@186801|Clostridia,3WIUA@541000|Ruminococcaceae	186801|Clostridia	S	aldo keto reductase family	-	-	-	ko:K07079	-	-	-	-	ko00000	-	-	-	Aldo_ket_red,Fer4_17
HKD1_k127_8014658_0	871968.DESME_02565	1.29e-198	626.0	COG1409@1|root,COG1409@2|Bacteria,1VDYM@1239|Firmicutes,24GDB@186801|Clostridia,262VZ@186807|Peptococcaceae	186801|Clostridia	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD1_k127_8025965_7	1121289.JHVL01000002_gene2333	5.139e-13	73.0	COG1308@1|root,COG1308@2|Bacteria,1V7I9@1239|Firmicutes,24M6Q@186801|Clostridia,36JCP@31979|Clostridiaceae	186801|Clostridia	K	UBA TS-N domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF4342
HKD1_k127_8025965_0	1128398.Curi_c18070	3.785e-255	792.0	COG0423@1|root,COG0423@2|Bacteria,1TP94@1239|Firmicutes,248FB@186801|Clostridia,267ZN@186813|unclassified Clostridiales	186801|Clostridia	J	Catalyzes the attachment of glycine to tRNA(Gly)	glyQS	GO:0003674,GO:0003824,GO:0004812,GO:0004820,GO:0005488,GO:0005515,GO:0016874,GO:0016875,GO:0046983,GO:0140098,GO:0140101	6.1.1.14	ko:K01880	ko00970,map00970	M00359,M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD1_k127_8025965_5	1121289.JHVL01000002_gene2330	1.189e-67	235.0	COG0517@1|root,COG0517@2|Bacteria,1TRZD@1239|Firmicutes,24851@186801|Clostridia,36F8X@31979|Clostridiaceae	186801|Clostridia	K	CBS domain	ccpN	-	-	-	-	-	-	-	-	-	-	-	CBS,HTH_11
HKD1_k127_8025965_4	1121289.JHVL01000002_gene2329	1.674e-98	329.0	COG1806@1|root,COG1806@2|Bacteria,1TPG0@1239|Firmicutes,249ID@186801|Clostridia,36EQ5@31979|Clostridiaceae	186801|Clostridia	S	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation	yqfL	-	2.7.11.33,2.7.4.28	ko:K09773	-	-	-	-	ko00000,ko01000	-	-	-	Kinase-PPPase
HKD1_k127_8025965_3	1304284.L21TH_2074	4.65e-128	417.0	COG0232@1|root,COG0232@2|Bacteria,1TPEI@1239|Firmicutes,247Q1@186801|Clostridia,36E9Q@31979|Clostridiaceae	186801|Clostridia	F	Deoxyguanosinetriphosphate triphosphohydrolase	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD1_k127_8025965_2	1304284.L21TH_2076	7.789e-129	432.0	COG0358@1|root,COG0358@2|Bacteria,1TQ0X@1239|Firmicutes,2480W@186801|Clostridia,36FK8@31979|Clostridiaceae	186801|Clostridia	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_bind,Toprim_2,Toprim_4,Toprim_N,zf-CHC2
HKD1_k127_8025965_1	1304284.L21TH_2077	1.455e-163	522.0	COG0568@1|root,COG0568@2|Bacteria,1TPD6@1239|Firmicutes,2481I@186801|Clostridia,36E45@31979|Clostridiaceae	186801|Clostridia	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	sigA	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD1_k127_8025965_6	1304284.L21TH_0411	3.207e-39	150.0	COG2384@1|root,COG2384@2|Bacteria,1V3I4@1239|Firmicutes,24BJI@186801|Clostridia,36FNA@31979|Clostridiaceae	186801|Clostridia	S	SAM-dependent methyltransferase	trmK	-	2.1.1.217	ko:K06967	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_18,TrmK
HKD1_k127_802851_0	944565.HMPREF9127_0592	3.471e-52	189.0	COG0244@1|root,COG0244@2|Bacteria,1V3JJ@1239|Firmicutes,24G9R@186801|Clostridia,22HI4@1570339|Peptoniphilaceae	186801|Clostridia	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD1_k127_802851_1	857293.CAAU_2115	6.14e-43	160.0	COG0222@1|root,COG0222@2|Bacteria,1V6EI@1239|Firmicutes,24JAC@186801|Clostridia,36IQP@31979|Clostridiaceae	186801|Clostridia	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD1_k127_8029414_1	1291050.JAGE01000001_gene888	8.996e-35	135.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1TQH1@1239|Firmicutes,249IS@186801|Clostridia,3WJEE@541000|Ruminococcaceae	186801|Clostridia	O	cytochrome c biogenesis protein transmembrane region	ccdA	-	-	ko:K06196	-	-	-	-	ko00000,ko02000	5.A.1.2	-	-	AhpC-TSA,DsbD,Redoxin
HKD1_k127_8029414_0	545697.HMPREF0216_02763	3.188e-85	291.0	COG4866@1|root,COG4866@2|Bacteria,1TR2J@1239|Firmicutes,2480E@186801|Clostridia,36GHZ@31979|Clostridiaceae	186801|Clostridia	S	Uncharacterised conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
HKD1_k127_8035883_0	1123288.SOV_4c03790	1.732e-96	319.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4H27J@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
HKD1_k127_8035883_1	1232452.BAIB02000007_gene1789	0.0004293	44.0	COG3328@1|root,COG3328@2|Bacteria,1TP4C@1239|Firmicutes,248UI@186801|Clostridia	186801|Clostridia	L	PFAM transposase, mutator	-	-	-	ko:K07493	-	-	-	-	ko00000	-	-	-	Transposase_mut
HKD1_k127_8036137_0	1385512.N784_05375	5.17e-92	305.0	COG2089@1|root,COG2089@2|Bacteria,1TS09@1239|Firmicutes,4HA1Y@91061|Bacilli	91061|Bacilli	M	synthase	-	-	2.5.1.56	ko:K01654	ko00520,ko01100,map00520,map01100	-	R01804,R04435	RC00159	ko00000,ko00001,ko01000	-	-	-	NeuB,SAF
HKD1_k127_8036137_1	1385512.N784_05380	5.956e-92	306.0	COG1083@1|root,COG1083@2|Bacteria,1UFAT@1239|Firmicutes,4HG7P@91061|Bacilli	91061|Bacilli	M	Cytidylyltransferase	neuA	-	-	-	-	-	-	-	-	-	-	-	CTP_transf_3
HKD1_k127_815657_0	1121324.CLIT_10c00580	8.75e-114	385.0	COG1948@1|root,COG4880@2|Bacteria,1TQK0@1239|Firmicutes,247VC@186801|Clostridia	186801|Clostridia	L	COG4880 Secreted protein containing C-terminal beta-propeller domain distantly related to WD-40 repeats	-	-	-	-	-	-	-	-	-	-	-	-	Beta_propel
HKD1_k127_841571_1	1408437.JNJN01000060_gene452	5.422e-16	89.0	COG0503@1|root,COG0739@1|root,COG0503@2|Bacteria,COG0739@2|Bacteria	2|Bacteria	M	heme binding	apt	-	2.4.2.7	ko:K00759	ko00230,ko01100,map00230,map01100	-	R00190,R01229,R04378	RC00063	ko00000,ko00001,ko01000,ko04147	-	-	-	NLPC_P60,Peptidase_M23,Pribosyltran
HKD1_k127_841571_0	1408437.JNJN01000002_gene1390	8.808e-33	135.0	28PXR@1|root,2ZCHM@2|Bacteria,1V24G@1239|Firmicutes,24G17@186801|Clostridia,25YJK@186806|Eubacteriaceae	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_847122_0	1304284.L21TH_0138	1.159e-263	820.0	COG0504@1|root,COG0504@2|Bacteria,1TP34@1239|Firmicutes,2482E@186801|Clostridia,36DBK@31979|Clostridiaceae	186801|Clostridia	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS01075	CTP_synth_N,GATase
HKD1_k127_847122_1	1121289.JHVL01000001_gene1907	6.553e-29	128.0	COG1388@1|root,COG1388@2|Bacteria,1TSVC@1239|Firmicutes,248VQ@186801|Clostridia,36EW2@31979|Clostridiaceae	186801|Clostridia	M	LysM domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF3794,LysM
HKD1_k127_866359_0	1304284.L21TH_1831	1.36e-33	133.0	COG0488@1|root,COG0488@2|Bacteria,1TPAX@1239|Firmicutes,247U6@186801|Clostridia,36E7X@31979|Clostridiaceae	186801|Clostridia	S	ABC transporter	-	-	-	ko:K06158	-	-	-	-	ko00000,ko03012	-	-	-	ABC_tran,ABC_tran_CTD,ABC_tran_Xtn
HKD1_k127_866359_1	1033737.CAEV01000076_gene557	8.669e-16	83.0	COG1396@1|root,COG1396@2|Bacteria,1VK84@1239|Firmicutes,24QK6@186801|Clostridia,36ND9@31979|Clostridiaceae	186801|Clostridia	K	Helix-turn-helix XRE-family like proteins	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
HKD1_k127_868175_2	500632.CLONEX_02291	1.073e-16	85.0	COG0513@1|root,COG0513@2|Bacteria,1TPAP@1239|Firmicutes,247IT@186801|Clostridia	186801|Clostridia	L	Belongs to the DEAD box helicase family	cshA	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD1_k127_868175_0	1541960.KQ78_00876	5.69e-134	438.0	COG0513@1|root,COG0513@2|Bacteria,3WSZ8@544448|Tenericutes	544448|Tenericutes	L	helicase superfamily c-terminal domain	deaD	-	3.6.4.13	ko:K05592	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019	-	-	-	DEAD,DbpA,Helicase_C
HKD1_k127_868175_1	1319815.HMPREF0202_01942	3.485e-65	231.0	COG2220@1|root,COG2220@2|Bacteria,378N3@32066|Fusobacteria	32066|Fusobacteria	S	Beta-lactamase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B_3
HKD1_k127_8767_0	1345695.CLSA_c19080	6.781e-182	575.0	COG1960@1|root,COG1960@2|Bacteria,1TP57@1239|Firmicutes,247UB@186801|Clostridia,36DR1@31979|Clostridiaceae	186801|Clostridia	I	acyl-CoA dehydrogenase	bcd	-	1.3.8.1	ko:K00248	ko00071,ko00280,ko00650,ko01100,ko01110,ko01120,ko01200,ko01212,map00071,map00280,map00650,map01100,map01110,map01120,map01200,map01212	-	R01175,R01178,R02661,R03172,R04751	RC00052,RC00068,RC00076,RC00120,RC00148	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD1_k127_8767_1	401526.TcarDRAFT_1838	1.774e-143	462.0	COG2025@1|root,COG2025@2|Bacteria,1TPC8@1239|Firmicutes,4H27J@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha,Fer4
HKD1_k127_8767_2	401526.TcarDRAFT_1837	1.943e-102	339.0	COG2086@1|root,COG2086@2|Bacteria,1TQA0@1239|Firmicutes,4H2QE@909932|Negativicutes	909932|Negativicutes	C	Electron transfer flavoprotein	etfB	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD1_k127_8946_0	1120998.AUFC01000005_gene631	3.842e-174	550.0	COG0078@1|root,COG0078@2|Bacteria,1TPF2@1239|Firmicutes,248I5@186801|Clostridia,3WCFU@538999|Clostridiales incertae sedis	186801|Clostridia	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	iHN637.CLJU_RS12430	OTCace,OTCace_N
HKD1_k127_8946_1	1120998.AUFC01000005_gene630	1.74e-144	464.0	COG0549@1|root,COG0549@2|Bacteria,1TP9H@1239|Firmicutes,2482W@186801|Clostridia,3WCY8@538999|Clostridiales incertae sedis	186801|Clostridia	E	Amino acid kinase family	-	-	2.7.2.2	ko:K00926	ko00220,ko00230,ko00910,ko01100,ko01120,ko01200,map00220,map00230,map00910,map01100,map01120,map01200	-	R00150,R01395	RC00002,RC00043,RC02803,RC02804	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD1_k127_8946_2	1211817.CCAT010000062_gene4057	1.817e-38	149.0	COG4187@1|root,COG4187@2|Bacteria,1TQQ7@1239|Firmicutes,249CV@186801|Clostridia,36EX1@31979|Clostridiaceae	186801|Clostridia	E	Peptidase family M20/M25/M40	rocB	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M20
HKD1_k127_89512_1	588581.Cpap_3434	2.686e-50	180.0	COG0302@1|root,COG0302@2|Bacteria,1TRNM@1239|Firmicutes,24867@186801|Clostridia,3WIA5@541000|Ruminococcaceae	186801|Clostridia	H	GTP cyclohydrolase I	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD1_k127_89512_3	1423724.BAMM01000023_gene1918	1.373e-08	58.0	28TVU@1|root,2ZG2M@2|Bacteria,1W4QC@1239|Firmicutes,4I1Y6@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD1_k127_89512_2	665571.STHERM_c02850	6.421e-09	67.0	COG4866@1|root,COG4866@2|Bacteria,2J5HZ@203691|Spirochaetes	203691|Spirochaetes	S	conserved protein (DUF2156)	-	-	-	ko:K01163	-	-	-	-	ko00000	-	-	-	DUF2156
HKD1_k127_89512_0	1123489.AUAN01000007_gene504	2.257e-75	256.0	COG0603@1|root,COG0603@2|Bacteria,1TP4Z@1239|Firmicutes,4H3F7@909932|Negativicutes	909932|Negativicutes	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD1_k127_93102_1	1121430.JMLG01000001_gene2301	3.612e-77	265.0	COG0665@1|root,COG0665@2|Bacteria,1VTRW@1239|Firmicutes,25F1Y@186801|Clostridia,263S3@186807|Peptococcaceae	186801|Clostridia	E	PFAM FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_93102_2	1265505.ATUG01000003_gene827	3.623e-53	189.0	COG1142@1|root,COG1142@2|Bacteria	2|Bacteria	C	4 iron, 4 sulfur cluster binding	-	-	1.2.1.58	ko:K18356	ko00360,map00360	-	R02450	RC00004,RC02860	br01601,ko00000,ko00001,ko01000	-	-	-	Fer4,Fer4_10,Fer4_11,Fer4_4,Fer4_6,Fer4_9,TPP_enzyme_C
HKD1_k127_93102_0	1265505.ATUG01000003_gene828	5.695e-215	670.0	COG2414@1|root,COG2414@2|Bacteria,1MWBB@1224|Proteobacteria,42NR7@68525|delta/epsilon subdivisions,2WK49@28221|Deltaproteobacteria,2MHYC@213118|Desulfobacterales	28221|Deltaproteobacteria	C	Aldehyde ferredoxin oxidoreductase	-	-	1.2.7.5	ko:K03738	ko00030,ko01100,ko01120,ko01200,map00030,map01100,map01120,map01200	M00309	R08571	RC00242	ko00000,ko00001,ko00002,ko01000	-	-	-	AFOR_C,AFOR_N
HKD1_k127_935224_1	720554.Clocl_0113	1.226e-59	210.0	COG0636@1|root,COG0636@2|Bacteria,1V786@1239|Firmicutes,24HBF@186801|Clostridia,3WJD9@541000|Ruminococcaceae	186801|Clostridia	C	ATP synthase subunit C	ntpK	-	-	ko:K02124	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	ATP-synt_C
HKD1_k127_935224_2	509191.AEDB02000049_gene4410	2.432e-51	184.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3WHFQ@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_935224_0	720554.Clocl_0114	8.632e-96	324.0	COG1269@1|root,COG1269@2|Bacteria,1TPTE@1239|Firmicutes,249YV@186801|Clostridia,3WHFQ@541000|Ruminococcaceae	186801|Clostridia	C	Belongs to the V-ATPase 116 kDa subunit family	ntpI	-	-	ko:K02123	ko00190,ko01100,map00190,map01100	M00159	-	-	ko00000,ko00001,ko00002	3.A.2.2,3.A.2.3	-	-	V_ATPase_I
HKD1_k127_936628_0	1345695.CLSA_c12060	3.693e-115	372.0	COG1853@1|root,COG1853@2|Bacteria,1V1EA@1239|Firmicutes,24FWS@186801|Clostridia,36FKV@31979|Clostridiaceae	186801|Clostridia	S	flavin reductase	-	-	-	-	-	-	-	-	-	-	-	-	Flavin_Reduct
HKD1_k127_936628_1	1196322.A370_04636	3.421e-90	298.0	COG1102@1|root,COG1102@2|Bacteria,1TRCW@1239|Firmicutes,249Z9@186801|Clostridia,36GVC@31979|Clostridiaceae	186801|Clostridia	F	Cytidylate kinase-like family	-	-	-	-	-	-	-	-	-	-	-	-	Cytidylate_kin2
HKD1_k127_971141_1	537013.CLOSTMETH_02607	1.81e-05	55.0	COG3314@1|root,COG3314@2|Bacteria,1TR0V@1239|Firmicutes,247XA@186801|Clostridia,3WJ7Z@541000|Ruminococcaceae	186801|Clostridia	S	Sporulation integral membrane protein YlbJ	ylbJ	-	-	-	-	-	-	-	-	-	-	-	Gate
HKD1_k127_971141_0	1292035.H476_2026	1.439e-32	138.0	COG1323@1|root,COG1323@2|Bacteria,1TPP2@1239|Firmicutes,247UP@186801|Clostridia,25QMM@186804|Peptostreptococcaceae	186801|Clostridia	S	Belongs to the UPF0348 family	-	-	-	-	-	-	-	-	-	-	-	-	HIGH_NTase1
HKD1_k127_98331_0	1304284.L21TH_0180	4.509e-157	502.0	COG0665@1|root,COG0665@2|Bacteria,1VTRW@1239|Firmicutes,25F1Y@186801|Clostridia,36GPM@31979|Clostridiaceae	186801|Clostridia	E	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00303	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	DAO
HKD1_k127_98331_6	1408422.JHYF01000001_gene3067	3.86e-28	115.0	COG1251@1|root,COG1251@2|Bacteria,1VI2I@1239|Firmicutes,24TGP@186801|Clostridia,36VCB@31979|Clostridiaceae	186801|Clostridia	C	BFD-like [2Fe-2S] binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_BFD
HKD1_k127_98331_4	1304284.L21TH_0182	3.548e-55	197.0	COG1149@1|root,COG1149@2|Bacteria,1V4I0@1239|Firmicutes,25FYJ@186801|Clostridia,36K71@31979|Clostridiaceae	186801|Clostridia	C	4Fe-4S binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer4
HKD1_k127_98331_1	1304284.L21TH_0183	2.266e-151	486.0	COG0446@1|root,COG0446@2|Bacteria,1TQH5@1239|Firmicutes,247YR@186801|Clostridia,36G6B@31979|Clostridiaceae	186801|Clostridia	C	FAD dependent oxidoreductase	-	-	1.5.3.1	ko:K00302	ko00260,ko01100,map00260,map01100	-	R00610	RC00060,RC00557	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD1_k127_98331_5	1304284.L21TH_0184	1.103e-47	173.0	COG3383@1|root,COG3383@2|Bacteria,1VAVK@1239|Firmicutes,24MYJ@186801|Clostridia,36KQK@31979|Clostridiaceae	186801|Clostridia	C	2Fe-2S iron-sulfur cluster binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Fer2_4
HKD1_k127_98331_2	536232.CLM_1493	2.376e-140	458.0	COG0569@1|root,COG0569@2|Bacteria,1TPNS@1239|Firmicutes,24830@186801|Clostridia,36ERV@31979|Clostridiaceae	186801|Clostridia	P	domain protein	trkA	-	-	ko:K03499	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkA_C,TrkA_N
HKD1_k127_98331_3	1499689.CCNN01000007_gene1941	1.338e-135	443.0	COG0168@1|root,COG0168@2|Bacteria,1TPAF@1239|Firmicutes,248K4@186801|Clostridia,36E52@31979|Clostridiaceae	186801|Clostridia	P	potassium uptake protein TrkH	trkH	-	-	ko:K03498	-	-	-	-	ko00000,ko02000	2.A.38.1,2.A.38.4	-	-	TrkH
## 2868 queries scanned
## Total time (seconds): 18.553852081298828
## Rate: 154.58 q/s