## Sat Nov 16 06:27:21 2024
## emapper-2.1.12
## /data/home/zkh/miniconda3/envs/eggnog-mapper/bin/emapper.py -i /data/home/zkh/binning/bin_4635/bin/bin8/HKD_2_bin.1.fa -m mmseqs --itype genome -o HKD_2_bin.1 --output_dir /data/home/zkh/meta_analysis/eggnog-mapper/4635/HKD_2_bin.1 --cpu 28
##
#query	seed_ortholog	evalue	score	eggNOG_OGs	max_annot_lvl	COG_category	Description	Preferred_name	GOs	EC	KEGG_ko	KEGG_Pathway	KEGG_Module	KEGG_Reaction	KEGG_rclass	BRITE	KEGG_TC	CAZy	BiGG_Reaction	PFAMs
HKD2_k127_10102200_2	319003.Bra1253DRAFT_08276	1.465e-27	117.0	COG0457@1|root,COG0457@2|Bacteria,1R8QI@1224|Proteobacteria,2U3CP@28211|Alphaproteobacteria,3JUFE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19
HKD2_k127_10102200_1	443598.AUFA01000032_gene6463	9.201e-83	278.0	2BYYX@1|root,32UJT@2|Bacteria,1R4FM@1224|Proteobacteria,2U390@28211|Alphaproteobacteria,3JXA5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_10102200_0	224911.27350958	1.52e-244	766.0	COG2358@1|root,COG2358@2|Bacteria,1R5N8@1224|Proteobacteria,2TSTB@28211|Alphaproteobacteria,3JQZS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	NMT1-like family	-	-	-	-	-	-	-	-	-	-	-	-	NMT1_3
HKD2_k127_10102200_3	189753.AXAS01000075_gene6004	2.155e-14	74.0	COG2984@1|root,COG2984@2|Bacteria,1MW5D@1224|Proteobacteria,2TSG1@28211|Alphaproteobacteria,3JSYZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	ABC transporter substrate binding protein	-	-	-	ko:K01989	-	M00247	-	-	ko00000,ko00002,ko02000	-	-	-	ABC_sub_bind
HKD2_k127_1044586_10	1123267.JONN01000001_gene1985	3.979e-144	466.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_1044586_3	93220.LV28_07855	1.22e-222	703.0	COG0526@1|root,COG0785@1|root,COG0526@2|Bacteria,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2VJF0@28216|Betaproteobacteria,1K43E@119060|Burkholderiaceae	28216|Betaproteobacteria	CO	cytochrome c biogenesis protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,DsbD,Redoxin
HKD2_k127_1044586_20	1123267.JONN01000001_gene1607	8.701e-64	222.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,2K4P6@204457|Sphingomonadales	204457|Sphingomonadales	O	conserved domain frequently associated with peptide methionine sulfoxide reductase	-	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_1044586_30	392499.Swit_3813	3.026e-19	93.0	298YE@1|root,2ZW29@2|Bacteria,1N9JF@1224|Proteobacteria,2UHRA@28211|Alphaproteobacteria,2K6ST@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1044586_12	990285.RGCCGE502_05699	1.287e-117	383.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,4BAHI@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_1044586_6	1123267.JONN01000001_gene692	6.499e-177	565.0	COG0498@1|root,COG0498@2|Bacteria,1R7X1@1224|Proteobacteria,2TUR3@28211|Alphaproteobacteria,2K0P7@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine synthase	-	-	4.2.3.1	ko:K01733	ko00260,ko00750,ko01100,ko01110,ko01120,ko01230,map00260,map00750,map01100,map01110,map01120,map01230	M00018	R01466,R05086	RC00017,RC00526	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_1044586_14	1096546.WYO_0036	5.244e-99	331.0	COG1230@1|root,COG1230@2|Bacteria,1MVQB@1224|Proteobacteria,2TR65@28211|Alphaproteobacteria,1JR56@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM cation diffusion facilitator family transporter	czcD	-	-	ko:K16264	-	-	-	-	ko00000,ko02000	2.A.4.1	-	-	Cation_efflux
HKD2_k127_1044586_22	1280952.HJA_09134	7.287e-53	188.0	2B9KW@1|root,322Z5@2|Bacteria,1RJJB@1224|Proteobacteria,2UAVD@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1044586_32	13689.BV96_02222	2.306e-16	82.0	29B0T@1|root,2ZXZQ@2|Bacteria,1ND25@1224|Proteobacteria,2UJ2J@28211|Alphaproteobacteria,2K6SU@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1044586_31	1123267.JONN01000001_gene689	7.995e-18	88.0	COG1983@1|root,COG1983@2|Bacteria	2|Bacteria	KT	positive regulation of macromolecule biosynthetic process	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD2_k127_1044586_16	1123267.JONN01000001_gene1114	1.357e-78	270.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,2U6CN@28211|Alphaproteobacteria,2K2DP@204457|Sphingomonadales	204457|Sphingomonadales	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_1044586_33	237727.NAP1_13728	5.384e-05	48.0	2AMI2@1|root,31CDP@2|Bacteria,1P2BA@1224|Proteobacteria,2UVHW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1044586_25	1123267.JONN01000001_gene685	2.938e-36	141.0	2CC0C@1|root,32ZJ1@2|Bacteria,1R3EF@1224|Proteobacteria,2U01N@28211|Alphaproteobacteria,2KEWT@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3297)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3297
HKD2_k127_1044586_0	1035191.HMPREF0185_02695	0.0	1324.0	COG0823@1|root,COG1228@1|root,COG0823@2|Bacteria,COG1228@2|Bacteria,1MX3A@1224|Proteobacteria,2TUU6@28211|Alphaproteobacteria,2KG4I@204458|Caulobacterales	204458|Caulobacterales	QU	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,PD40
HKD2_k127_1044586_4	1123267.JONN01000001_gene683	1.704e-219	694.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TSEI@28211|Alphaproteobacteria,2K13V@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1071 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit	-	-	-	-	-	-	-	-	-	-	-	-	E1_dh,OxoDH_E1alpha_N
HKD2_k127_1044586_5	1123267.JONN01000001_gene682	4.692e-192	603.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2K02S@204457|Sphingomonadales	204457|Sphingomonadales	C	COG0022 Pyruvate 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit	bkdA2	-	1.2.4.4	ko:K00167	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_1044586_7	1123267.JONN01000001_gene681	4.54e-173	552.0	COG0508@1|root,COG0508@2|Bacteria,1MU7K@1224|Proteobacteria,2TS31@28211|Alphaproteobacteria,2K1MM@204457|Sphingomonadales	204457|Sphingomonadales	C	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex	bkdB	-	2.3.1.168	ko:K09699	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R02662,R03174,R04097,R10998	RC00004,RC02727,RC02870	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_1044586_26	1123267.JONN01000001_gene680	1.346e-31	131.0	2DXAI@1|root,3444M@2|Bacteria,1P0TN@1224|Proteobacteria,2UVMP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_3
HKD2_k127_1044586_15	1192034.CAP_8271	1.192e-85	292.0	COG0384@1|root,COG0384@2|Bacteria,1MUAS@1224|Proteobacteria,42RA9@68525|delta/epsilon subdivisions,2WQIZ@28221|Deltaproteobacteria,2Z0UK@29|Myxococcales	28221|Deltaproteobacteria	S	Phenazine biosynthesis-like protein	-	-	5.3.3.17	ko:K06998	ko00405,ko01130,ko02024,map00405,map01130,map02024	M00835	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	PhzC-PhzF
HKD2_k127_1044586_21	1121124.JNIX01000001_gene1039	9.14e-56	203.0	COG1418@1|root,COG1418@2|Bacteria	2|Bacteria	S	mRNA catabolic process	-	-	-	ko:K06950	-	-	-	-	ko00000	-	-	-	HD
HKD2_k127_1044586_28	555793.WSK_1788	1.736e-25	113.0	2DD18@1|root,2ZG4B@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1044586_17	935565.JAEM01000025_gene245	3.805e-78	265.0	COG1182@1|root,COG1182@2|Bacteria,1P59R@1224|Proteobacteria,2U8Z1@28211|Alphaproteobacteria,2PWT8@265|Paracoccus	28211|Alphaproteobacteria	I	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity	azoR	-	-	ko:K01118	-	-	-	-	ko00000,ko01000	-	-	-	Flavodoxin_2
HKD2_k127_1044586_23	1123267.JONN01000001_gene677	3.505e-51	185.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2UC19@28211|Alphaproteobacteria,2K6D3@204457|Sphingomonadales	204457|Sphingomonadales	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_1044586_9	1449076.JOOE01000001_gene2089	1.389e-144	464.0	COG1064@1|root,COG1064@2|Bacteria,1MUTT@1224|Proteobacteria,2TTI9@28211|Alphaproteobacteria,2K29S@204457|Sphingomonadales	204457|Sphingomonadales	S	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K13953	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N
HKD2_k127_1044586_1	1123267.JONN01000001_gene676	0.0	1172.0	COG2609@1|root,COG2609@2|Bacteria,1MV21@1224|Proteobacteria,2TSZ9@28211|Alphaproteobacteria,2K18V@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, thiamine diphosphate binding domain	-	-	1.2.4.1	ko:K00163	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_N
HKD2_k127_1044586_18	1120705.FG95_01961	3.543e-69	237.0	COG2030@1|root,COG2030@2|Bacteria,1MW4N@1224|Proteobacteria,2TQQ2@28211|Alphaproteobacteria,2K42I@204457|Sphingomonadales	204457|Sphingomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_1044586_13	1123267.JONN01000001_gene674	4.282e-115	391.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2E1@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD2_k127_1044586_2	291985.CCSI01000004_gene605	1.175e-299	929.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRKS@28211|Alphaproteobacteria,2K0M5@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA	acsA	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACAS_N,AMP-binding,AMP-binding_C,DUF779
HKD2_k127_1044586_29	1090319.KE386571_gene2108	5.963e-25	113.0	2AKZG@1|root,31BT4@2|Bacteria,1Q7R6@1224|Proteobacteria,2VDWQ@28211|Alphaproteobacteria,2K6B3@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3833)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3833
HKD2_k127_1044586_19	426117.M446_4787	2.379e-65	232.0	COG5662@1|root,COG5662@2|Bacteria,1MV95@1224|Proteobacteria,2TVRG@28211|Alphaproteobacteria,1JU5T@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	AntiSigma factor	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_1044586_24	864069.MicloDRAFT_00052060	4.03e-45	171.0	COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria,1JVJ8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	TIGRFAM RNA polymerase sigma factor, sigma-70 family	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_1044586_27	395965.Msil_0391	4.057e-31	125.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria,3NBM7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD2_k127_1044586_11	78245.Xaut_0974	1.717e-132	428.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2TTSK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_1044586_8	745310.G432_00370	8.514e-146	468.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TRAP@28211|Alphaproteobacteria,2K0IY@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD2_k127_1302467_28	392499.Swit_2252	6.212e-78	263.0	COG1960@1|root,COG1960@2|Bacteria,1MX17@1224|Proteobacteria,2TTRE@28211|Alphaproteobacteria,2K20J@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K18244	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_1302467_8	392499.Swit_2253	1.919e-187	592.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K0FW@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_1302467_16	392499.Swit_2258	2.338e-132	428.0	COG1028@1|root,COG1028@2|Bacteria,1PFUB@1224|Proteobacteria,2U149@28211|Alphaproteobacteria,2K2UZ@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	ko:K13774	ko00281,map00281	-	R08087,R08096,R10125,R10126	RC00080,RC00087	ko00000,ko00001	-	-	-	adh_short_C2
HKD2_k127_1302467_51	1397666.RS24_00355	1.812e-28	122.0	COG2128@1|root,COG2128@2|Bacteria	2|Bacteria	S	hydroperoxide reductase activity	ahpD	-	-	ko:K04756	-	-	-	-	ko00000	-	-	-	CMD
HKD2_k127_1302467_1	392499.Swit_1323	3.343e-268	839.0	COG1520@1|root,COG2010@1|root,COG1520@2|Bacteria,COG2010@2|Bacteria,1PIDE@1224|Proteobacteria,2TTS3@28211|Alphaproteobacteria,2K3QU@204457|Sphingomonadales	204457|Sphingomonadales	C	PQQ-like domain	-	-	1.1.2.6	ko:K05889	-	-	R03136	-	ko00000,ko01000	-	-	-	Cytochrome_CBB3,PQQ,PQQ_2,PQQ_3
HKD2_k127_1302467_0	702113.PP1Y_Mpl5263	0.0	1060.0	COG1629@1|root,COG4771@2|Bacteria,1R5XT@1224|Proteobacteria,2U4AA@28211|Alphaproteobacteria,2K9PP@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,TonB_dep_Rec
HKD2_k127_1302467_3	702113.PP1Y_Mpl5466	4.154e-222	695.0	COG4638@1|root,COG4638@2|Bacteria,1PXC0@1224|Proteobacteria,2TRF7@28211|Alphaproteobacteria,2K4CJ@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_1302467_53	392499.Swit_2265	6.09e-28	119.0	COG1359@1|root,COG1359@2|Bacteria,1NAV0@1224|Proteobacteria,2UJ8F@28211|Alphaproteobacteria,2KAPX@204457|Sphingomonadales	204457|Sphingomonadales	C	Antibiotic biosynthesis monooxygenase	-	-	5.3.1.32	ko:K11530	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	ABM
HKD2_k127_1302467_2	392499.Swit_2266	1.958e-258	809.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2K2MS@204457|Sphingomonadales	204457|Sphingomonadales	IQ	AMP-dependent synthetase and ligase	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_1302467_47	392499.Swit_2267	4.175e-34	133.0	COG1359@1|root,COG1359@2|Bacteria,1NZAF@1224|Proteobacteria,2USRM@28211|Alphaproteobacteria,2KAX9@204457|Sphingomonadales	204457|Sphingomonadales	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_1302467_44	392499.Swit_2255	2.756e-43	164.0	COG0346@1|root,COG0346@2|Bacteria,1MWHG@1224|Proteobacteria,2UF29@28211|Alphaproteobacteria,2K7AS@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase_4
HKD2_k127_1302467_15	158500.BV97_02853	1.359e-148	482.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TTQT@28211|Alphaproteobacteria,2KCXA@204457|Sphingomonadales	204457|Sphingomonadales	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_1302467_10	392499.Swit_2269	4.702e-181	572.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,2K2MQ@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, pyrimidine binding domain	-	-	-	ko:K21417	-	-	-	-	ko00000,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_1302467_11	392499.Swit_2270	2.98e-163	522.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRW0@28211|Alphaproteobacteria,2K2Z1@204457|Sphingomonadales	204457|Sphingomonadales	C	Dehydrogenase E1 component	-	-	-	ko:K21416	-	-	-	-	ko00000,ko01000	-	-	-	E1_dh
HKD2_k127_1302467_5	1219035.NT2_07_01140	8.308e-219	685.0	COG4638@1|root,COG4638@2|Bacteria,1MXZN@1224|Proteobacteria,2U2X0@28211|Alphaproteobacteria,2KCF5@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_1302467_17	392499.Swit_2272	1.059e-128	414.0	COG1028@1|root,COG1028@2|Bacteria,1MW46@1224|Proteobacteria,2TUTU@28211|Alphaproteobacteria,2K1ME@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_1302467_36	1411685.U062_01960	1.068e-55	203.0	COG1028@1|root,COG1028@2|Bacteria,1NB6S@1224|Proteobacteria,1TA6H@1236|Gammaproteobacteria,1JA7B@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_1302467_24	392499.Swit_2259	2.169e-98	327.0	COG1028@1|root,COG1028@2|Bacteria,1MUPX@1224|Proteobacteria,2U471@28211|Alphaproteobacteria,2K3WA@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.51	ko:K05296	ko00140,ko00984,ko01100,ko01120,map00140,map00984,map01100,map01120	-	R01836,R01838,R02352,R02353,R03406,R03407,R09956,R09957	RC00127,RC00144	ko00000,ko00001,ko01000	-	-	-	adh_short_C2
HKD2_k127_1302467_32	392499.Swit_2273	3.454e-72	249.0	COG1309@1|root,COG1309@2|Bacteria,1RJ1Z@1224|Proteobacteria,2VF35@28211|Alphaproteobacteria,2KDB6@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_1302467_20	392499.Swit_2274	1.348e-105	347.0	COG3828@1|root,COG3828@2|Bacteria,1QWCA@1224|Proteobacteria,2U1GQ@28211|Alphaproteobacteria,2K19I@204457|Sphingomonadales	204457|Sphingomonadales	S	Trehalose utilisation	-	-	-	ko:K09992	-	-	-	-	ko00000	-	-	-	ThuA
HKD2_k127_1302467_9	1219035.NT2_07_01260	4.769e-184	583.0	COG1804@1|root,COG1804@2|Bacteria,1MVY1@1224|Proteobacteria,2TVJ9@28211|Alphaproteobacteria,2K2DX@204457|Sphingomonadales	204457|Sphingomonadales	C	CoA-transferase family III	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_1302467_48	392499.Swit_2276	1.504e-32	129.0	COG1545@1|root,COG1545@2|Bacteria,1N2C8@1224|Proteobacteria,2U8C7@28211|Alphaproteobacteria,2KAG1@204457|Sphingomonadales	204457|Sphingomonadales	S	DUF35 OB-fold domain, acyl-CoA-associated	-	-	-	ko:K07068	-	-	-	-	ko00000	-	-	-	DUF35_N,OB_aCoA_assoc
HKD2_k127_1302467_12	392499.Swit_2277	1.846e-160	516.0	COG0183@1|root,COG0183@2|Bacteria,1MUZV@1224|Proteobacteria,2TRHF@28211|Alphaproteobacteria,2K1XH@204457|Sphingomonadales	204457|Sphingomonadales	I	acetyl-coa acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C
HKD2_k127_1302467_6	1123267.JONN01000001_gene865	6.932e-197	624.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TSA0@28211|Alphaproteobacteria,2K081@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_1302467_13	1112214.AHIS01000101_gene1692	6.05e-153	493.0	COG0446@1|root,COG0446@2|Bacteria,1NR3M@1224|Proteobacteria,2TS0K@28211|Alphaproteobacteria,2K12H@204457|Sphingomonadales	204457|Sphingomonadales	S	pyridine nucleotide-disulfide oxidoreductase	-	-	1.18.1.3	ko:K00529	ko00071,ko00360,ko01120,ko01220,map00071,map00360,map01120,map01220	M00545	R02000,R06782,R06783	RC00098	br01602,ko00000,ko00001,ko00002,ko01000	-	-	-	Pyr_redox_2,Reductase_C
HKD2_k127_1302467_46	1248760.ANFZ01000013_gene1872	2.53e-36	143.0	COG0633@1|root,COG0633@2|Bacteria,1N261@1224|Proteobacteria,2UC7B@28211|Alphaproteobacteria,2K5DE@204457|Sphingomonadales	204457|Sphingomonadales	C	ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD2_k127_1302467_43	1282360.ABAC460_23415	7.05e-44	168.0	COG0457@1|root,COG0457@2|Bacteria,1N9D5@1224|Proteobacteria,2UIQ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1302467_55	485913.Krac_9650	1.602e-08	67.0	COG4585@1|root,COG4585@2|Bacteria,2G88D@200795|Chloroflexi	200795|Chloroflexi	T	histidine kinase, dimerisation and phosphoacceptor region	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,GAF_3,HATPase_c,HisKA_3
HKD2_k127_1302467_41	1282361.ABAC402_12635	9.969e-48	179.0	COG3439@1|root,COG3439@2|Bacteria,1MZ38@1224|Proteobacteria,2U7V5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_1302467_30	1096546.WYO_1095	2.696e-73	254.0	COG0431@1|root,COG0431@2|Bacteria,1MXQ8@1224|Proteobacteria,2TRI5@28211|Alphaproteobacteria,1JRCT@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	NADPH-dependent FMN reductase	MA20_28735	-	-	-	-	-	-	-	-	-	-	-	FMN_red
HKD2_k127_1302467_14	187303.BN69_2141	7.399e-152	492.0	COG1752@1|root,COG1752@2|Bacteria,1MVHW@1224|Proteobacteria,2TS4V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	esterase of the alpha-beta hydrolase superfamily	MA20_17270	-	-	ko:K07001	-	-	-	-	ko00000	-	-	-	DUF3734,Patatin
HKD2_k127_1302467_18	187303.BN69_2140	3.367e-114	374.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,36XET@31993|Methylocystaceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short,adh_short_C2
HKD2_k127_1302467_45	420324.KI912069_gene6362	2.669e-37	147.0	COG1917@1|root,COG1917@2|Bacteria,1PBNJ@1224|Proteobacteria,2U1VG@28211|Alphaproteobacteria,1JY54@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_1302467_25	1380391.JIAS01000011_gene4709	1.084e-97	336.0	COG0477@1|root,COG2814@2|Bacteria,1MWFH@1224|Proteobacteria,2TR0R@28211|Alphaproteobacteria,2JR1G@204441|Rhodospirillales	204441|Rhodospirillales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_1302467_52	395019.Bmul_1430	5.213e-28	130.0	COG0599@1|root,COG0599@2|Bacteria,1RH7V@1224|Proteobacteria,2VR3W@28216|Betaproteobacteria,1K7M2@119060|Burkholderiaceae	28216|Betaproteobacteria	S	carboxymuconolactone decarboxylase	-	-	4.1.1.44	ko:K01607	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	-	R03470	RC00938	ko00000,ko00001,ko01000	-	-	-	CMD
HKD2_k127_1302467_27	1380391.JIAS01000011_gene4712	4.873e-81	280.0	COG0583@1|root,COG0583@2|Bacteria,1R51E@1224|Proteobacteria,2TZIK@28211|Alphaproteobacteria,2JX1S@204441|Rhodospirillales	204441|Rhodospirillales	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1302467_49	1038858.AXBA01000004_gene51	1.181e-28	120.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2UBV0@28211|Alphaproteobacteria,3F1W4@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
HKD2_k127_1302467_19	1144319.PMI16_00225	5.675e-107	357.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2VKP0@28216|Betaproteobacteria,4763F@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF692)	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD2_k127_1302467_50	667632.KB890176_gene4546	1.197e-28	124.0	COG3219@1|root,COG3219@2|Bacteria,1QAP4@1224|Proteobacteria,2VR01@28216|Betaproteobacteria,1K38A@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD2_k127_1302467_38	1346791.M529_00390	6.038e-52	187.0	COG2259@1|root,COG2259@2|Bacteria,1N1VA@1224|Proteobacteria,2TVZ9@28211|Alphaproteobacteria,2K5X8@204457|Sphingomonadales	204457|Sphingomonadales	S	DoxX	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD2_k127_1302467_37	1112214.AHIS01000074_gene3235	1.651e-53	194.0	2AFT8@1|root,315VF@2|Bacteria,1RAPJ@1224|Proteobacteria,2U6M6@28211|Alphaproteobacteria,2K2CZ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1302467_7	1449076.JOOE01000004_gene517	6.697e-189	600.0	COG0277@1|root,COG0277@2|Bacteria,1MU6Y@1224|Proteobacteria,2TRYI@28211|Alphaproteobacteria,2K0VP@204457|Sphingomonadales	204457|Sphingomonadales	C	FAD linked	-	-	-	-	-	-	-	-	-	-	-	-	FAD-oxidase_C,FAD_binding_4
HKD2_k127_1302467_34	1123267.JONN01000001_gene1533	1.372e-64	225.0	COG0262@1|root,COG0262@2|Bacteria,1RH0P@1224|Proteobacteria,2U9GC@28211|Alphaproteobacteria,2K4ET@204457|Sphingomonadales	204457|Sphingomonadales	H	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis	folA	-	1.5.1.3	ko:K00287	ko00670,ko00790,ko01100,ko01523,map00670,map00790,map01100,map01523	M00126,M00840	R00936,R00937,R00939,R00940,R02235,R02236,R11765	RC00109,RC00110,RC00158	ko00000,ko00001,ko00002,ko01000	-	-	-	DHFR_1
HKD2_k127_1302467_35	1123267.JONN01000001_gene1534	3.121e-56	202.0	COG3832@1|root,COG3832@2|Bacteria,1RH7Z@1224|Proteobacteria,2U9E1@28211|Alphaproteobacteria,2K54H@204457|Sphingomonadales	204457|Sphingomonadales	J	glyoxalase III activity	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1,Polyketide_cyc2
HKD2_k127_1302467_23	1123267.JONN01000001_gene1535	8.158e-100	331.0	COG0563@1|root,COG0563@2|Bacteria,1MXCZ@1224|Proteobacteria,2TT6A@28211|Alphaproteobacteria,2JZW8@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism	adk	-	2.7.4.3	ko:K00939	ko00230,ko00730,ko01100,ko01110,ko01130,map00230,map00730,map01100,map01110,map01130	M00049	R00127,R01547,R11319	RC00002	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ADK,ADK_lid
HKD2_k127_1302467_4	1123267.JONN01000001_gene1536	1.459e-221	694.0	COG0201@1|root,COG0201@2|Bacteria,1MVU7@1224|Proteobacteria,2TQMT@28211|Alphaproteobacteria,2JZY0@204457|Sphingomonadales	204457|Sphingomonadales	U	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently	secY	-	-	ko:K03076	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5	-	-	SecY
HKD2_k127_1302467_29	1123267.JONN01000001_gene1537	5.323e-75	257.0	COG0200@1|root,COG0200@2|Bacteria,1RDC8@1224|Proteobacteria,2U79D@28211|Alphaproteobacteria,2K40W@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds to the 23S rRNA	rplO	-	-	ko:K02876	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L27A
HKD2_k127_1302467_54	1123267.JONN01000001_gene1538	7.701e-22	100.0	COG1841@1|root,COG1841@2|Bacteria,1PU2S@1224|Proteobacteria,2UF55@28211|Alphaproteobacteria,2K6V8@204457|Sphingomonadales	204457|Sphingomonadales	J	Ribosomal protein L30	rpmD	-	-	ko:K02907	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L30
HKD2_k127_1302467_21	1030157.AFMP01000051_gene321	4.148e-105	346.0	COG0098@1|root,COG0098@2|Bacteria,1MUS4@1224|Proteobacteria,2TSRI@28211|Alphaproteobacteria,2K10Y@204457|Sphingomonadales	204457|Sphingomonadales	J	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body	rpsE	-	-	ko:K02988	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S5,Ribosomal_S5_C
HKD2_k127_1302467_40	392499.Swit_1337	7.955e-51	182.0	COG0256@1|root,COG0256@2|Bacteria,1RGY7@1224|Proteobacteria,2U9A6@28211|Alphaproteobacteria,2K52X@204457|Sphingomonadales	204457|Sphingomonadales	J	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance	rplR	-	-	ko:K02881	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L18p
HKD2_k127_1302467_26	1123267.JONN01000001_gene1542	5.151e-93	308.0	COG0097@1|root,COG0097@2|Bacteria,1R9YZ@1224|Proteobacteria,2TV09@28211|Alphaproteobacteria,2K149@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center	rplF	-	-	ko:K02933	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L6
HKD2_k127_1302467_31	1123267.JONN01000001_gene1543	3.569e-73	247.0	COG0096@1|root,COG0096@2|Bacteria,1RDG3@1224|Proteobacteria,2U6ZH@28211|Alphaproteobacteria,2K3ZU@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit	rpsH	-	-	ko:K02994	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S8
HKD2_k127_1302467_39	1123267.JONN01000001_gene1544	1.042e-51	183.0	COG0199@1|root,COG0199@2|Bacteria,1MZDT@1224|Proteobacteria,2UC01@28211|Alphaproteobacteria,2K53G@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site	rpsN	-	-	ko:K02954	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S14
HKD2_k127_1302467_22	1123267.JONN01000001_gene1545	6.09e-102	336.0	COG0094@1|root,COG0094@2|Bacteria,1MUU9@1224|Proteobacteria,2TQPF@28211|Alphaproteobacteria,2K0S5@204457|Sphingomonadales	204457|Sphingomonadales	J	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits	rplE	-	-	ko:K02931	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L5,Ribosomal_L5_C
HKD2_k127_1302467_42	685778.AORL01000010_gene2748	7.343e-47	171.0	COG0198@1|root,COG0198@2|Bacteria,1MZQD@1224|Proteobacteria,2UC6Y@28211|Alphaproteobacteria,2K52R@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit	rplX	-	-	ko:K02895	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KOW,ribosomal_L24
HKD2_k127_1302467_33	1123267.JONN01000001_gene1547	5.77e-70	237.0	COG0093@1|root,COG0093@2|Bacteria,1RCWZ@1224|Proteobacteria,2U743@28211|Alphaproteobacteria,2K4G3@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome	rplN	-	-	ko:K02874	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L14
HKD2_k127_1335349_2	1205680.CAKO01000010_gene3911	1.974e-120	398.0	COG1063@1|root,COG1063@2|Bacteria,1NXSN@1224|Proteobacteria	1224|Proteobacteria	E	Glucose dehydrogenase C-terminus	gcd	-	-	-	-	-	-	-	-	-	-	-	ADH_N,Glu_dehyd_C
HKD2_k127_1335349_5	1095769.CAHF01000025_gene653	1.654e-47	175.0	COG4288@1|root,COG4288@2|Bacteria,1RHKE@1224|Proteobacteria,2VSI7@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Anabaena sensory rhodopsin transducer	-	-	-	-	-	-	-	-	-	-	-	-	ASRT
HKD2_k127_1335349_4	78245.Xaut_1996	3.301e-99	329.0	COG1028@1|root,COG1028@2|Bacteria,1MURZ@1224|Proteobacteria,2TQJ6@28211|Alphaproteobacteria,3EYZ9@335928|Xanthobacteraceae	28211|Alphaproteobacteria	IQ	Enoyl-(Acyl carrier protein) reductase	MA20_27190	-	1.1.1.30	ko:K00019,ko:K18335	ko00051,ko00072,ko00650,ko01100,ko01120,map00051,map00072,map00650,map01100,map01120	M00088	R01361,R10690	RC00089,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HKD2_k127_1335349_0	78245.Xaut_1998	1.132e-294	914.0	COG0129@1|root,COG0129@2|Bacteria,1MV4I@1224|Proteobacteria,2TQRW@28211|Alphaproteobacteria,3EYGG@335928|Xanthobacteraceae	28211|Alphaproteobacteria	EG	Dehydratase family	MA20_27195	-	4.2.1.82,4.2.1.9	ko:K01687,ko:K22186	ko00040,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00040,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R01209,R02429,R04441,R05070	RC00468,RC00543,RC01714	ko00000,ko00001,ko00002,ko01000	-	-	-	ILVD_EDD
HKD2_k127_1335349_1	1267005.KB911255_gene2685	1.219e-140	453.0	COG0179@1|root,COG0179@2|Bacteria,1MUPF@1224|Proteobacteria,2TQQG@28211|Alphaproteobacteria,3N7HS@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	Q	Fumarylacetoacetate (FAA) hydrolase family	MA20_19215	-	5.3.3.10	ko:K01826	ko00350,ko01120,ko01220,map00350,map01120,map01220	M00533	R04379,R04482	RC01141,RC01162	ko00000,ko00001,ko00002,ko01000	-	-	-	FAA_hydrolase
HKD2_k127_1335349_3	551275.KB899546_gene1908	1.32e-110	363.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,43WQ0@69657|Hyphomonadaceae	28211|Alphaproteobacteria	P	ammonium transporter	amtB	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_1405884_48	1280954.HPO_00275	2.968e-05	57.0	COG3710@1|root,COG5616@1|root,COG3710@2|Bacteria,COG5616@2|Bacteria,1PF3H@1224|Proteobacteria,2V7F9@28211|Alphaproteobacteria,43YSF@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	Transcriptional regulatory protein, C terminal	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,Trans_reg_C
HKD2_k127_1405884_32	1123267.JONN01000002_gene285	6.035e-33	147.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1N7YB@1224|Proteobacteria,2V7CZ@28211|Alphaproteobacteria,2K2SU@204457|Sphingomonadales	204457|Sphingomonadales	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD2_k127_1405884_14	1123267.JONN01000001_gene1037	1.818e-104	345.0	COG1058@1|root,COG1058@2|Bacteria,1MVG6@1224|Proteobacteria,2TU5C@28211|Alphaproteobacteria,2K05Q@204457|Sphingomonadales	204457|Sphingomonadales	S	nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA	-	-	-	-	-	-	-	-	-	-	-	-	MoCF_biosynth
HKD2_k127_1405884_5	1449076.JOOE01000002_gene1447	6.613e-153	487.0	COG0024@1|root,COG0024@2|Bacteria,1MU99@1224|Proteobacteria,2TQTH@28211|Alphaproteobacteria,2K0AR@204457|Sphingomonadales	204457|Sphingomonadales	E	Methionine aminopeptidase	map	-	3.4.11.18	ko:K01265	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M24
HKD2_k127_1405884_28	1123267.JONN01000001_gene629	4.602e-56	198.0	COG0824@1|root,COG0824@2|Bacteria,1RHB1@1224|Proteobacteria,2UATC@28211|Alphaproteobacteria,2K4SF@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,Acyl-ACP_TE
HKD2_k127_1405884_34	1267533.KB906738_gene2275	1.046e-28	120.0	COG0251@1|root,COG0251@2|Bacteria	2|Bacteria	J	oxidation-reduction process	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_1405884_36	384765.SIAM614_20680	2.13e-20	92.0	COG1942@1|root,COG1942@2|Bacteria,1NBW3@1224|Proteobacteria,2UHFK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	4-oxalocrotonate tautomerase	-	-	5.3.2.6	ko:K01821	ko00362,ko00621,ko00622,ko01100,ko01120,ko01220,map00362,map00621,map00622,map01100,map01120,map01220	M00569	R03966,R05389	RC01040,RC01355	ko00000,ko00001,ko00002,ko01000	-	-	-	Tautomerase
HKD2_k127_1405884_29	194867.ALBQ01000013_gene873	2.675e-53	195.0	2EC7R@1|root,33669@2|Bacteria,1NQFV@1224|Proteobacteria,2UMAZ@28211|Alphaproteobacteria,2K7H7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1405884_18	1123267.JONN01000001_gene1034	2.679e-95	319.0	COG1213@1|root,COG1213@2|Bacteria,1RB54@1224|Proteobacteria,2U5XC@28211|Alphaproteobacteria,2K2S2@204457|Sphingomonadales	204457|Sphingomonadales	M	Nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3,NTP_transferase
HKD2_k127_1405884_27	1123267.JONN01000001_gene1033	3.117e-56	198.0	COG0347@1|root,COG0347@2|Bacteria,1RGWK@1224|Proteobacteria,2U73Z@28211|Alphaproteobacteria,2K4IQ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the P(II) protein family	glnB	-	-	ko:K04751	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	P-II
HKD2_k127_1405884_33	1123267.JONN01000001_gene1032	8.876e-29	117.0	2B3XE@1|root,31WMD@2|Bacteria,1P4DI@1224|Proteobacteria,2UW3Y@28211|Alphaproteobacteria,2KBX1@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Phage_CI_repr
HKD2_k127_1405884_43	1090320.KB900605_gene2232	1.513e-09	64.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UJHN@28211|Alphaproteobacteria,2K61Q@204457|Sphingomonadales	204457|Sphingomonadales	DTZ	EF-hand, calcium binding motif	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD2_k127_1405884_49	1045855.DSC_15060	0.00041	49.0	COG5126@1|root,COG5126@2|Bacteria,1Q9CZ@1224|Proteobacteria,1TETQ@1236|Gammaproteobacteria,1XBTR@135614|Xanthomonadales	135614|Xanthomonadales	DTZ	EF-hand domain pair	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD2_k127_1405884_7	1090320.KB900605_gene635	1.12e-139	453.0	COG0408@1|root,COG0408@2|Bacteria,1MWMF@1224|Proteobacteria,2TQNC@28211|Alphaproteobacteria,2K084@204457|Sphingomonadales	204457|Sphingomonadales	H	coproporphyrinogen III oxidase	hemF	-	1.3.3.3	ko:K00228	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03220	RC00884	ko00000,ko00001,ko00002,ko01000	-	-	-	Coprogen_oxidas
HKD2_k127_1405884_23	1030157.AFMP01000062_gene3529	6.724e-67	237.0	COG0454@1|root,COG0454@2|Bacteria,1RDGT@1224|Proteobacteria,2TRF5@28211|Alphaproteobacteria,2K22G@204457|Sphingomonadales	204457|Sphingomonadales	K	N-acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_1405884_38	13690.CP98_01056	1.035e-17	93.0	2BJGF@1|root,32DT8@2|Bacteria,1NRPG@1224|Proteobacteria,2UPT5@28211|Alphaproteobacteria,2K7DE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	GPDPase_memb
HKD2_k127_1405884_19	1123267.JONN01000001_gene539	2.367e-88	302.0	COG0321@1|root,COG0321@2|Bacteria,1MU6A@1224|Proteobacteria,2TRXJ@28211|Alphaproteobacteria,2K28T@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate	lipB	-	2.3.1.181	ko:K03801	ko00785,ko01100,map00785,map01100	-	R07766,R07769	RC00039,RC00992,RC02867	ko00000,ko00001,ko01000	-	-	-	BPL_LplA_LipB
HKD2_k127_1405884_16	1123267.JONN01000001_gene536	5.302e-103	338.0	COG0602@1|root,COG0602@2|Bacteria,1MUJ2@1224|Proteobacteria,2TU1S@28211|Alphaproteobacteria,2K21H@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7- carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds	queE	-	4.3.99.3	ko:K10026	ko00790,ko01100,map00790,map01100	-	R10002	RC02989	ko00000,ko00001,ko01000,ko03016	-	-	-	Fer4_14,Radical_SAM
HKD2_k127_1405884_12	1123267.JONN01000001_gene535	1.146e-116	378.0	COG0603@1|root,COG0603@2|Bacteria,1MU5V@1224|Proteobacteria,2TU7F@28211|Alphaproteobacteria,2K0K0@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))	queC	-	6.3.4.20	ko:K06920	ko00790,ko01100,map00790,map01100	-	R09978	RC00959	ko00000,ko00001,ko01000,ko03016	-	-	-	QueC
HKD2_k127_1405884_39	1123267.JONN01000001_gene534	6.966e-15	80.0	2AI43@1|root,318I3@2|Bacteria,1NCMB@1224|Proteobacteria,2UFPI@28211|Alphaproteobacteria,2K76K@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1405884_6	1123267.JONN01000001_gene533	5.408e-140	451.0	COG1281@1|root,COG1281@2|Bacteria,1MUMU@1224|Proteobacteria,2TTUR@28211|Alphaproteobacteria,2K0YD@204457|Sphingomonadales	204457|Sphingomonadales	O	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress	hslO	-	-	ko:K04083	-	-	-	-	ko00000,ko03110	-	-	-	HSP33
HKD2_k127_1405884_30	1248916.ANFY01000003_gene664	5.68e-47	172.0	2E129@1|root,32WI1@2|Bacteria,1NVE4@1224|Proteobacteria,2URU9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD2_k127_1405884_4	1123267.JONN01000001_gene532	2.185e-211	661.0	COG4992@1|root,COG4992@2|Bacteria,1MV3C@1224|Proteobacteria,2TSGT@28211|Alphaproteobacteria,2K0I4@204457|Sphingomonadales	204457|Sphingomonadales	E	acetylornithine aminotransferase	argD	-	2.6.1.11,2.6.1.17	ko:K00821	ko00220,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00220,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00028,M00845	R02283,R04475	RC00006,RC00062	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_1405884_10	1123267.JONN01000001_gene530	2.345e-125	406.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,2K23E@204457|Sphingomonadales	204457|Sphingomonadales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_1405884_17	1123267.JONN01000001_gene529	1.328e-95	330.0	COG5352@1|root,COG5352@2|Bacteria,1RHI6@1224|Proteobacteria,2TS7F@28211|Alphaproteobacteria,2K0A1@204457|Sphingomonadales	204457|Sphingomonadales	S	GcrA cell cycle regulator	-	-	-	ko:K13583	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	GcrA
HKD2_k127_1405884_15	1123269.NX02_27645	4.643e-103	357.0	COG2267@1|root,COG3629@1|root,COG2267@2|Bacteria,COG3629@2|Bacteria,1QU9N@1224|Proteobacteria,2TW44@28211|Alphaproteobacteria,2K7FJ@204457|Sphingomonadales	204457|Sphingomonadales	IT	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_1405884_21	402881.Plav_1108	6.465e-72	265.0	COG1917@1|root,COG2207@1|root,COG1917@2|Bacteria,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2TW52@28211|Alphaproteobacteria,1JPD9@119043|Rhodobiaceae	28211|Alphaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD2_k127_1405884_20	450851.PHZ_c1673	9.198e-80	277.0	2CCCK@1|root,2Z7UH@2|Bacteria,1R3SV@1224|Proteobacteria,2UH90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1405884_22	1123269.NX02_27640	7.441e-69	238.0	COG1765@1|root,COG1765@2|Bacteria,1MWPR@1224|Proteobacteria,2U1VW@28211|Alphaproteobacteria,2K5RK@204457|Sphingomonadales	204457|Sphingomonadales	O	OsmC-like protein	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_1405884_11	1502850.FG91_00756	5.757e-119	387.0	COG0500@1|root,COG2226@2|Bacteria,1MXP4@1224|Proteobacteria,2TQU4@28211|Alphaproteobacteria,2KCTI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Mycolic acid cyclopropane synthetase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_1405884_26	1123267.JONN01000001_gene528	3.154e-58	208.0	COG0071@1|root,COG0071@2|Bacteria,1RH2X@1224|Proteobacteria,2U96D@28211|Alphaproteobacteria,2K489@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the small heat shock protein (HSP20) family	-	-	-	ko:K04080	-	-	-	-	ko00000,ko03110	-	-	-	HSP20
HKD2_k127_1405884_0	1123267.JONN01000001_gene527	0.0	1084.0	COG0187@1|root,COG0187@2|Bacteria,1MVH1@1224|Proteobacteria,2TQZV@28211|Alphaproteobacteria,2K2GE@204457|Sphingomonadales	204457|Sphingomonadales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parE	-	-	ko:K02622	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_1405884_25	266779.Meso_1256	1.511e-60	214.0	COG1495@1|root,COG1495@2|Bacteria,1RKPG@1224|Proteobacteria,2U89W@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Disulfide bond formation protein DsbB	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
HKD2_k127_1405884_1	194867.ALBQ01000042_gene1358	5.289e-299	922.0	COG3278@1|root,COG3278@2|Bacteria,1MU18@1224|Proteobacteria,2TR2C@28211|Alphaproteobacteria,2K1TD@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the heme-copper respiratory oxidase family	ccoN	-	1.9.3.1	ko:K00404	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002,ko01000	3.D.4.3	-	-	COX1
HKD2_k127_1405884_13	1346791.M529_07160	6.507e-112	367.0	COG2993@1|root,COG2993@2|Bacteria,1MXEY@1224|Proteobacteria,2TRGW@28211|Alphaproteobacteria,2K220@204457|Sphingomonadales	204457|Sphingomonadales	C	Peptidase S41	ccoO	-	-	ko:K00405	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixO
HKD2_k127_1405884_44	1522072.IL54_2908	1.285e-08	59.0	COG4736@1|root,COG4736@2|Bacteria,1NGV0@1224|Proteobacteria,2UJBS@28211|Alphaproteobacteria,2K7TM@204457|Sphingomonadales	204457|Sphingomonadales	O	Cbb3-type cytochrome oxidase component FixQ	-	-	-	ko:K00407	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	FixQ
HKD2_k127_1405884_8	1081640.AGFU01000033_gene2974	1.399e-135	438.0	COG2010@1|root,COG2010@2|Bacteria,1MUCW@1224|Proteobacteria,2TQW1@28211|Alphaproteobacteria,2K23A@204457|Sphingomonadales	204457|Sphingomonadales	C	C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex	ccoP	-	-	ko:K00406	ko00190,ko01100,ko02020,map00190,map01100,map02020	M00156	-	-	ko00000,ko00001,ko00002	3.D.4.3	-	-	Cytochrome_CBB3,FixP_N
HKD2_k127_1405884_3	1112212.JH584235_gene1609	2.217e-222	699.0	COG0348@1|root,COG0348@2|Bacteria,1MVFY@1224|Proteobacteria,2TRYB@28211|Alphaproteobacteria,2K0BY@204457|Sphingomonadales	204457|Sphingomonadales	C	Nitrogen fixation protein fixG	ccoG	-	-	-	-	-	-	-	-	-	-	-	Fer4_18,Fer4_5,FixG_C
HKD2_k127_1405884_31	1248916.ANFY01000014_gene35	4.105e-34	138.0	COG5456@1|root,COG5456@2|Bacteria,1RHKI@1224|Proteobacteria,2U9GB@28211|Alphaproteobacteria,2K623@204457|Sphingomonadales	204457|Sphingomonadales	P	Integral membrane protein linked to a cation	-	-	-	-	-	-	-	-	-	-	-	-	FixH
HKD2_k127_1405884_2	1112212.JH584235_gene1607	1.64e-243	775.0	COG2217@1|root,COG2217@2|Bacteria,1MU08@1224|Proteobacteria,2TR80@28211|Alphaproteobacteria,2K0EB@204457|Sphingomonadales	204457|Sphingomonadales	P	P-type ATPase	-	-	3.6.3.4	ko:K01533	-	-	R00086	RC00002	ko00000,ko01000	3.A.3.5	-	-	E1-E2_ATPase,HMA,Hydrolase
HKD2_k127_1405884_42	1112212.JH584235_gene1606	1.477e-13	76.0	COG3197@1|root,COG3197@2|Bacteria,1NG90@1224|Proteobacteria,2UJFJ@28211|Alphaproteobacteria,2K7T0@204457|Sphingomonadales	204457|Sphingomonadales	P	Cytochrome oxidase maturation protein cbb3-type	-	-	-	-	-	-	-	-	-	-	-	-	FixS
HKD2_k127_1405884_9	1096930.L284_05130	7.343e-132	436.0	COG0635@1|root,COG0635@2|Bacteria,1MV1I@1224|Proteobacteria,2TRKT@28211|Alphaproteobacteria,2K1GX@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the anaerobic coproporphyrinogen-III oxidase family	hemN	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_1405884_35	1267535.KB906767_gene1543	1.601e-28	119.0	2CN2H@1|root,32SG5@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1405884_45	1174684.EBMC1_07845	3.136e-08	61.0	COG3682@1|root,COG3682@2|Bacteria,1N95N@1224|Proteobacteria,2UISP@28211|Alphaproteobacteria,2K5C7@204457|Sphingomonadales	204457|Sphingomonadales	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD2_k127_1405884_24	1123267.JONN01000001_gene1985	1.02e-66	233.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_1441662_3	685778.AORL01000021_gene419	1.745e-46	171.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria,2K0WZ@204457|Sphingomonadales	204457|Sphingomonadales	J	2-methylthioadenine	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HKD2_k127_1441662_0	1123267.JONN01000001_gene1123	3.079e-159	505.0	COG0552@1|root,COG0552@2|Bacteria,1MUDU@1224|Proteobacteria,2TS0M@28211|Alphaproteobacteria,2K03J@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ftsY	-	-	ko:K03110	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2,3.A.5.7	-	-	SRP54,SRP54_N
HKD2_k127_1441662_1	1123267.JONN01000001_gene1122	1.041e-94	320.0	COG2917@1|root,COG2917@2|Bacteria,1NWIZ@1224|Proteobacteria,2U74X@28211|Alphaproteobacteria,2K4N8@204457|Sphingomonadales	204457|Sphingomonadales	D	probably involved in intracellular septation	ispZ	-	-	ko:K06190	-	-	-	-	ko00000	-	-	-	IspA
HKD2_k127_1441662_2	196490.AUEZ01000002_gene4303	3.125e-84	282.0	COG0410@1|root,COG0410@2|Bacteria,1QNQ5@1224|Proteobacteria,2TRA5@28211|Alphaproteobacteria,3JX0C@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ATPases associated with a variety of cellular activities	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_1451283_3	794846.AJQU01000189_gene5691	5.068e-17	83.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,4BA8N@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
HKD2_k127_1451283_0	398525.KB900701_gene2986	3.162e-195	611.0	COG4974@1|root,COG4974@2|Bacteria,1MXZX@1224|Proteobacteria,2U0B6@28211|Alphaproteobacteria,3JWH2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase, N-terminal SAM-like domain	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_1451283_2	398525.KB900701_gene2987	9.206e-183	574.0	COG0582@1|root,COG0582@2|Bacteria,1NX90@1224|Proteobacteria,2TV8K@28211|Alphaproteobacteria,3JRYH@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD2_k127_1451283_1	398525.KB900701_gene2988	8.887e-189	597.0	COG4974@1|root,COG4974@2|Bacteria,1QUHS@1224|Proteobacteria,2U1XE@28211|Alphaproteobacteria,3JYM7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_1451283_4	366394.Smed_6199	1.903e-05	49.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria,4B7NK@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Transposase	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
HKD2_k127_1548231_3	622637.KE124774_gene3452	2.64e-54	196.0	COG1514@1|root,COG1514@2|Bacteria	2|Bacteria	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	ligT	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_1548231_2	243233.MCA1212	2.19e-98	333.0	COG0430@1|root,COG0430@2|Bacteria,1MX7Q@1224|Proteobacteria,1RSFF@1236|Gammaproteobacteria,1XE7B@135618|Methylococcales	135618|Methylococcales	A	Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP	rtcA	GO:0003674,GO:0003824,GO:0003963,GO:0006139,GO:0006396,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009975,GO:0009987,GO:0010467,GO:0016070,GO:0016874,GO:0016886,GO:0034641,GO:0043170,GO:0044237,GO:0044238,GO:0046483,GO:0071704,GO:0090304,GO:0140098,GO:1901360	6.5.1.4	ko:K01974	-	-	-	-	ko00000,ko01000	-	-	-	RTC,RTC_insert
HKD2_k127_1548231_0	69279.BG36_14065	1.24e-321	1003.0	COG1067@1|root,COG1067@2|Bacteria,1MWGB@1224|Proteobacteria,2TU7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Belongs to the peptidase S16 family	-	-	-	-	-	-	-	-	-	-	-	-	AAA_32,Lon_C
HKD2_k127_1548231_4	991905.SL003B_2621	1.734e-16	90.0	2EVJY@1|root,33P02@2|Bacteria,1NMNA@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1548231_1	631454.N177_1753	7.961e-267	829.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,1JNGM@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	-	-	-	-	-	-	-	-	-	-	-	-	Cpn60_TCP1
HKD2_k127_1548231_7	1238182.C882_1027	3.23e-05	51.0	2E4J2@1|root,32ZE4@2|Bacteria,1N7YM@1224|Proteobacteria,2UBV9@28211|Alphaproteobacteria,2JU1G@204441|Rhodospirillales	204441|Rhodospirillales	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
HKD2_k127_1548231_6	1380394.JADL01000002_gene1294	5.582e-11	63.0	2DJKR@1|root,32YT5@2|Bacteria,1NACC@1224|Proteobacteria,2UIBJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1548231_5	1297863.APJF01000040_gene1789	4.708e-13	69.0	2DJKR@1|root,32YT5@2|Bacteria,1NACC@1224|Proteobacteria,2UDCH@28211|Alphaproteobacteria,3K0FK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1645861_74	1123267.JONN01000002_gene325	3.511e-52	197.0	COG2200@1|root,COG4252@1|root,COG2200@2|Bacteria,COG4252@2|Bacteria,1N299@1224|Proteobacteria,2U5C8@28211|Alphaproteobacteria,2K2WP@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,EAL
HKD2_k127_1645861_78	1030157.AFMP01000036_gene2682	3.578e-43	160.0	COG3288@1|root,COG3288@2|Bacteria,1MZ3E@1224|Proteobacteria,2UBXS@28211|Alphaproteobacteria,2K5AR@204457|Sphingomonadales	204457|Sphingomonadales	C	nad(P) transhydrogenase subunit alpha	pntAB	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB_4TM
HKD2_k127_1645861_9	194867.ALBQ01000039_gene3107	1.716e-240	752.0	COG1282@1|root,COG1282@2|Bacteria,1MUP4@1224|Proteobacteria,2TQN1@28211|Alphaproteobacteria,2K05C@204457|Sphingomonadales	204457|Sphingomonadales	C	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane	pntB	-	1.6.1.2	ko:K00325	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	PNTB
HKD2_k127_1645861_48	1123267.JONN01000002_gene328	2.44e-90	303.0	COG1794@1|root,COG1794@2|Bacteria,1MV03@1224|Proteobacteria,2TRKQ@28211|Alphaproteobacteria,2KD7T@204457|Sphingomonadales	204457|Sphingomonadales	M	aspartate racemase	-	-	5.1.1.13	ko:K01779	ko00250,ko01054,map00250,map01054	-	R00491	RC00302	ko00000,ko00001,ko01000	-	-	-	Asp_Glu_race
HKD2_k127_1645861_33	383381.EH30_02410	3.3e-116	392.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,2TTMN@28211|Alphaproteobacteria,2K2YU@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_8
HKD2_k127_1645861_3	1123267.JONN01000002_gene332	0.0	1054.0	COG0322@1|root,COG0322@2|Bacteria,1MV38@1224|Proteobacteria,2TT32@28211|Alphaproteobacteria,2K1TK@204457|Sphingomonadales	204457|Sphingomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision	uvrC	-	-	ko:K03703	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	GIY-YIG,HHH_5,UVR,UvrC_HhH_N
HKD2_k127_1645861_51	46429.BV95_01462	7.966e-86	299.0	COG1381@1|root,COG1381@2|Bacteria,1MVEJ@1224|Proteobacteria,2TTYW@28211|Alphaproteobacteria,2K120@204457|Sphingomonadales	204457|Sphingomonadales	L	Involved in DNA repair and RecF pathway recombination	recO	-	-	ko:K03584	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecO_C,RecO_N
HKD2_k127_1645861_72	1123267.JONN01000002_gene334	2.667e-53	190.0	COG2967@1|root,COG2967@2|Bacteria,1MZ2Z@1224|Proteobacteria,2U9JM@28211|Alphaproteobacteria,2K4GR@204457|Sphingomonadales	204457|Sphingomonadales	P	protein affecting Mg2 Co2 transport	apaG	-	-	ko:K06195	-	-	-	-	ko00000	-	-	-	DUF525
HKD2_k127_1645861_35	754035.Mesau_05047	4.587e-113	376.0	COG0438@1|root,COG0438@2|Bacteria,1N0DG@1224|Proteobacteria,2TU8I@28211|Alphaproteobacteria,43PEB@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	PFAM Glycosyl transferases group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_trans_4_2,Glycos_transf_1
HKD2_k127_1645861_53	1123267.JONN01000002_gene230	8.841e-82	279.0	COG0639@1|root,COG0639@2|Bacteria,1RD8M@1224|Proteobacteria,2U7N2@28211|Alphaproteobacteria,2K1WW@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0639 Diadenosine tetraphosphatase and related serine threonine protein phosphatases	-	-	3.1.3.16	ko:K07313	-	-	-	-	ko00000,ko01000	-	-	-	Metallophos
HKD2_k127_1645861_57	1123267.JONN01000002_gene232	8.536e-80	274.0	COG1596@1|root,COG1596@2|Bacteria,1RE48@1224|Proteobacteria,2UEIX@28211|Alphaproteobacteria,2KCT0@204457|Sphingomonadales	204457|Sphingomonadales	M	polysaccharide export	-	-	-	ko:K01991	ko02026,map02026	-	-	-	ko00000,ko00001,ko02000	1.B.18	-	-	Poly_export,SLBB
HKD2_k127_1645861_7	1123267.JONN01000002_gene233	2.752e-251	796.0	COG0489@1|root,COG3206@1|root,COG0489@2|Bacteria,COG3206@2|Bacteria,1MVI9@1224|Proteobacteria,2TT1Y@28211|Alphaproteobacteria,2K00D@204457|Sphingomonadales	204457|Sphingomonadales	D	protein involved in exopolysaccharide biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31,GNVR,Wzz
HKD2_k127_1645861_84	1112214.AHIS01000077_gene3758	3.013e-32	140.0	2AM6I@1|root,31C14@2|Bacteria,1Q7ZG@1224|Proteobacteria,2VE57@28211|Alphaproteobacteria,2K7BV@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1645861_52	1123267.JONN01000002_gene235	3.081e-82	290.0	COG3307@1|root,COG3307@2|Bacteria,1N225@1224|Proteobacteria,2U6JI@28211|Alphaproteobacteria,2K3WT@204457|Sphingomonadales	204457|Sphingomonadales	M	O-Antigen ligase	-	-	-	-	-	-	-	-	-	-	-	-	Wzy_C
HKD2_k127_1645861_93	84531.JMTZ01000009_gene3254	3.897e-19	96.0	2FKTE@1|root,34CDW@2|Bacteria,1P9VS@1224|Proteobacteria,1TD7U@1236|Gammaproteobacteria,1XAAE@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1645861_31	1173022.Cri9333_2780	2.247e-121	409.0	COG0726@1|root,COG1216@1|root,COG0726@2|Bacteria,COG1216@2|Bacteria,1G4R3@1117|Cyanobacteria,1HA0S@1150|Oscillatoriales	1117|Cyanobacteria	M	glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_7C,Glycos_transf_2
HKD2_k127_1645861_81	452637.Oter_2504	8.612e-34	144.0	COG1216@1|root,COG1216@2|Bacteria,46VR2@74201|Verrucomicrobia	74201|Verrucomicrobia	S	PFAM glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_1645861_22	1144307.PMI04_02905	1.783e-162	523.0	COG0154@1|root,COG0154@2|Bacteria,1MU51@1224|Proteobacteria,2TSYS@28211|Alphaproteobacteria,2K1WY@204457|Sphingomonadales	204457|Sphingomonadales	J	Amidase	-	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_1645861_88	745310.G432_18715	1.051e-28	118.0	COG3609@1|root,COG3609@2|Bacteria,1N2U3@1224|Proteobacteria,2UC2F@28211|Alphaproteobacteria,2KEE5@204457|Sphingomonadales	204457|Sphingomonadales	K	addiction module	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1645861_87	983920.Y88_3859	1.09e-29	123.0	COG3668@1|root,COG3668@2|Bacteria,1RI5Y@1224|Proteobacteria,2UAAC@28211|Alphaproteobacteria,2K6FD@204457|Sphingomonadales	204457|Sphingomonadales	S	ParE toxin of type II toxin-antitoxin system, parDE	-	-	-	ko:K19092	-	-	-	-	ko00000,ko02048	-	-	-	ParE_toxin
HKD2_k127_1645861_79	565045.NOR51B_661	1.736e-42	158.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,1S1FB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_32,LZ_Tnp_IS481,rve,rve_3
HKD2_k127_1645861_75	1123267.JONN01000001_gene1419	4.486e-48	177.0	COG0801@1|root,COG0801@2|Bacteria,1MZH8@1224|Proteobacteria,2U8D6@28211|Alphaproteobacteria,2K57H@204457|Sphingomonadales	204457|Sphingomonadales	H	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase	folK	-	2.7.6.3	ko:K00950	ko00790,ko01100,map00790,map01100	M00126,M00841	R03503	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	HPPK
HKD2_k127_1645861_47	1123267.JONN01000001_gene1418	9.348e-92	306.0	COG1573@1|root,COG1573@2|Bacteria,1MW91@1224|Proteobacteria,2TSUP@28211|Alphaproteobacteria,2K0J4@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_1645861_23	1123267.JONN01000001_gene1415	8.167e-157	501.0	COG0388@1|root,COG0388@2|Bacteria,1MXG5@1224|Proteobacteria,2TVCS@28211|Alphaproteobacteria,2K0V3@204457|Sphingomonadales	204457|Sphingomonadales	S	N-carbamoylputrescine amidase	aguB	-	3.5.1.53	ko:K12251	ko00330,ko01100,map00330,map01100	-	R01152	RC00096	ko00000,ko00001,ko01000	-	-	-	CN_hydrolase
HKD2_k127_1645861_26	1123267.JONN01000001_gene1413	2.596e-149	478.0	COG2957@1|root,COG2957@2|Bacteria,1MX65@1224|Proteobacteria,2U0RR@28211|Alphaproteobacteria,2K0B9@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the agmatine deiminase family	-	-	3.5.3.12	ko:K10536	ko00330,ko01100,map00330,map01100	-	R01416	RC00177	ko00000,ko00001,ko01000	-	-	-	PAD_porph
HKD2_k127_1645861_17	1384056.N787_12110	6.007e-197	633.0	COG1506@1|root,COG1506@2|Bacteria,1MUJ3@1224|Proteobacteria,1RPAW@1236|Gammaproteobacteria,1X45I@135614|Xanthomonadales	135614|Xanthomonadales	E	peptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S9
HKD2_k127_1645861_32	1123267.JONN01000001_gene1411	8.361e-117	378.0	COG0522@1|root,COG0522@2|Bacteria,1MW0U@1224|Proteobacteria,2TRQH@28211|Alphaproteobacteria,2K0KZ@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit	rpsD	-	-	ko:K02986	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S4,S4
HKD2_k127_1645861_37	1123267.JONN01000001_gene1408	6.931e-108	355.0	COG0565@1|root,COG2827@1|root,COG0565@2|Bacteria,COG2827@2|Bacteria,1N47Y@1224|Proteobacteria,2TS8J@28211|Alphaproteobacteria,2JZUG@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA	trmJ	-	-	ko:K02533	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	GIY-YIG,SpoU_methylase
HKD2_k127_1645861_65	452662.SJA_C1-21800	3.834e-63	220.0	COG1327@1|root,COG1327@2|Bacteria,1RE7V@1224|Proteobacteria,2U75W@28211|Alphaproteobacteria,2K3W4@204457|Sphingomonadales	204457|Sphingomonadales	K	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes	nrdR	-	-	ko:K07738	-	-	-	-	ko00000,ko03000	-	-	-	ATP-cone
HKD2_k127_1645861_10	1123267.JONN01000001_gene1406	1.093e-238	748.0	COG0112@1|root,COG0112@2|Bacteria,1MUIS@1224|Proteobacteria,2TQKT@28211|Alphaproteobacteria,2K0BB@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism	glyA	-	2.1.2.1	ko:K00600	ko00260,ko00460,ko00630,ko00670,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko01523,map00260,map00460,map00630,map00670,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map01523	M00140,M00141,M00346,M00532	R00945,R09099	RC00022,RC00112,RC01583,RC02958	ko00000,ko00001,ko00002,ko01000	-	-	-	SHMT
HKD2_k127_1645861_62	1123267.JONN01000001_gene1405	5.737e-65	224.0	COG0698@1|root,COG0698@2|Bacteria,1RHBF@1224|Proteobacteria,2U94R@28211|Alphaproteobacteria,2K4KN@204457|Sphingomonadales	204457|Sphingomonadales	G	Ribose 5-phosphate isomerase	rpiB	-	5.3.1.6	ko:K01808	ko00030,ko00051,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00051,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01056,R09030	RC00376,RC00434	ko00000,ko00001,ko00002,ko01000	-	-	-	LacAB_rpiB
HKD2_k127_1645861_60	450851.PHZ_c2202	2.876e-77	273.0	COG0491@1|root,COG0491@2|Bacteria	2|Bacteria	GM	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_1645861_98	1120950.KB892750_gene6815	8.634e-07	59.0	COG1266@1|root,COG1266@2|Bacteria,2IS6T@201174|Actinobacteria	201174|Actinobacteria	S	CAAX protease self-immunity	-	-	-	-	-	-	-	-	-	-	-	-	Abi
HKD2_k127_1645861_14	1123267.JONN01000001_gene1402	5.001e-223	696.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQXI@28211|Alphaproteobacteria,2K08Q@204457|Sphingomonadales	204457|Sphingomonadales	E	5-aminolevulinic acid synthase	hemA	-	2.3.1.37	ko:K00643	ko00260,ko00860,ko01100,ko01110,map00260,map00860,map01100,map01110	-	R00830	RC00004,RC02815	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_1645861_38	1123267.JONN01000001_gene1401	2.289e-105	352.0	COG0796@1|root,COG0796@2|Bacteria,1NAI2@1224|Proteobacteria,2TSR7@28211|Alphaproteobacteria,2K1X9@204457|Sphingomonadales	204457|Sphingomonadales	M	Provides the (R)-glutamate required for cell wall biosynthesis	murI	-	5.1.1.3	ko:K01776	ko00471,ko01100,map00471,map01100	-	R00260	RC00302	ko00000,ko00001,ko01000,ko01011	-	-	-	Asp_Glu_race
HKD2_k127_1645861_63	1123267.JONN01000001_gene1400	2.304e-64	230.0	COG0344@1|root,COG0344@2|Bacteria,1RD4Z@1224|Proteobacteria,2U7BZ@28211|Alphaproteobacteria,2K0BP@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP	plsY	-	2.3.1.15	ko:K08591	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	G3P_acyltransf
HKD2_k127_1645861_0	1123267.JONN01000001_gene1398	0.0	1286.0	COG0550@1|root,COG0550@2|Bacteria,1MUFZ@1224|Proteobacteria,2TRGN@28211|Alphaproteobacteria,2K2HN@204457|Sphingomonadales	204457|Sphingomonadales	L	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone	topA	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_bac,Toprim,Toprim_C_rpt,zf-C4_Topoisom
HKD2_k127_1645861_61	392499.Swit_4879	5.429e-69	238.0	COG0756@1|root,COG0756@2|Bacteria,1RA7P@1224|Proteobacteria,2U7B5@28211|Alphaproteobacteria,2K4E7@204457|Sphingomonadales	204457|Sphingomonadales	F	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA	dut	-	3.6.1.23	ko:K01520	ko00240,ko00983,ko01100,map00240,map00983,map01100	M00053	R02100,R11896	RC00002	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	dUTPase
HKD2_k127_1645861_43	1123267.JONN01000001_gene1397	3.371e-100	336.0	COG0476@1|root,COG0476@2|Bacteria,1MW7H@1224|Proteobacteria,2TRWY@28211|Alphaproteobacteria,2K1F9@204457|Sphingomonadales	204457|Sphingomonadales	H	COG0476 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2	moeB	-	2.7.7.80	ko:K21029	ko04122,map04122	-	R07459	RC00043	ko00000,ko00001,ko01000	-	-	-	ThiF
HKD2_k127_1645861_54	1081640.AGFU01000052_gene843	4.329e-81	276.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,2K0N6@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_1645861_58	1123267.JONN01000001_gene1395	2.532e-79	267.0	COG0452@1|root,COG0452@2|Bacteria,1MVQP@1224|Proteobacteria,2TRN1@28211|Alphaproteobacteria,2K0N6@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine	coaBC	-	4.1.1.36,6.3.2.5	ko:K13038	ko00770,ko01100,map00770,map01100	M00120	R03269,R04231	RC00064,RC00090,RC00822	ko00000,ko00001,ko00002,ko01000	-	-	-	DFP,Flavoprotein
HKD2_k127_1645861_5	1123267.JONN01000001_gene1829	4.563e-269	841.0	COG4805@1|root,COG4805@2|Bacteria,1R4HM@1224|Proteobacteria,2TTG9@28211|Alphaproteobacteria,2K3EP@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (DUF885)	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_1645861_11	392499.Swit_4883	1.205e-236	741.0	COG0661@1|root,COG0661@2|Bacteria,1MU1Z@1224|Proteobacteria,2TS87@28211|Alphaproteobacteria,2K1BA@204457|Sphingomonadales	204457|Sphingomonadales	S	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis	ubiB	-	-	ko:K03688	-	-	-	-	ko00000	-	-	-	ABC1
HKD2_k127_1645861_34	1123267.JONN01000001_gene1389	4.892e-114	376.0	COG0500@1|root,COG2226@2|Bacteria,1MX8I@1224|Proteobacteria,2TRWR@28211|Alphaproteobacteria,2K080@204457|Sphingomonadales	204457|Sphingomonadales	H	Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2- polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2)	ubiE	-	2.1.1.163,2.1.1.201	ko:K03183	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00116,M00117	R04990,R04993,R06859,R08774,R09736	RC00003,RC01253,RC01662	ko00000,ko00001,ko00002,ko01000	-	-	-	Ubie_methyltran
HKD2_k127_1645861_30	1123267.JONN01000001_gene1388	6.433e-133	428.0	COG0266@1|root,COG0266@2|Bacteria,1MVM5@1224|Proteobacteria,2TS4C@28211|Alphaproteobacteria,2K2A5@204457|Sphingomonadales	204457|Sphingomonadales	L	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates	fpg	-	3.2.2.23,4.2.99.18	ko:K10563	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Fapy_DNA_glyco,H2TH,zf-FPG_IleRS
HKD2_k127_1645861_86	1122970.AUHC01000013_gene1088	2.381e-31	124.0	COG0268@1|root,COG0268@2|Bacteria,1MZ94@1224|Proteobacteria,2UC42@28211|Alphaproteobacteria,2K617@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds directly to 16S ribosomal RNA	rpsT	-	-	ko:K02968	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S20p
HKD2_k127_1645861_18	1030157.AFMP01000031_gene2866	1.23e-185	591.0	COG0593@1|root,COG0593@2|Bacteria,1MU5H@1224|Proteobacteria,2TT03@28211|Alphaproteobacteria,2JZZ0@204457|Sphingomonadales	204457|Sphingomonadales	L	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids	dnaA	-	-	ko:K02313	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001,ko03032,ko03036	-	-	-	Bac_DnaA,Bac_DnaA_C,DnaA_N
HKD2_k127_1645861_89	69395.JQLZ01000009_gene1831	6.543e-28	121.0	COG3932@1|root,COG3932@2|Bacteria,1MZD5@1224|Proteobacteria,2UD5A@28211|Alphaproteobacteria,2KH0E@204458|Caulobacterales	204458|Caulobacterales	S	PFAM Exopolysaccharide synthesis ExoD	-	-	-	-	-	-	-	-	-	-	-	-	ExoD
HKD2_k127_1645861_24	1123267.JONN01000001_gene1381	2.061e-151	491.0	COG0180@1|root,COG0180@2|Bacteria,1MV4T@1224|Proteobacteria,2TQZX@28211|Alphaproteobacteria,2K24N@204457|Sphingomonadales	204457|Sphingomonadales	J	Tryptophanyl-tRNA synthetase	trpS	-	6.1.1.2	ko:K01867	ko00970,map00970	M00359,M00360	R03664	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1b
HKD2_k127_1645861_8	1090319.KE386571_gene1096	6.527e-248	774.0	COG0728@1|root,COG0728@2|Bacteria,1MUH0@1224|Proteobacteria,2TS44@28211|Alphaproteobacteria,2K03M@204457|Sphingomonadales	204457|Sphingomonadales	S	Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane	murJ	-	-	ko:K03980	-	-	-	-	ko00000,ko01011,ko02000	2.A.66.4	-	-	MVIN
HKD2_k127_1645861_66	1123267.JONN01000001_gene1379	4.194e-62	217.0	COG1952@1|root,COG1952@2|Bacteria,1RI75@1224|Proteobacteria,2UBTB@28211|Alphaproteobacteria,2K4QA@204457|Sphingomonadales	204457|Sphingomonadales	U	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA	secB	-	-	ko:K03071	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03110	3.A.5	-	-	SecB
HKD2_k127_1645861_55	1123267.JONN01000001_gene1378	4.834e-81	274.0	COG4395@1|root,COG4395@2|Bacteria,1NCIX@1224|Proteobacteria,2TTDQ@28211|Alphaproteobacteria,2K0UG@204457|Sphingomonadales	204457|Sphingomonadales	S	import inner membrane translocase, subunit Tim44	-	-	-	-	-	-	-	-	-	-	-	-	Tim44
HKD2_k127_1645861_29	1123267.JONN01000001_gene1377	4.801e-137	451.0	COG2821@1|root,COG2821@2|Bacteria,1MXD4@1224|Proteobacteria,2TS5S@28211|Alphaproteobacteria,2K0IG@204457|Sphingomonadales	204457|Sphingomonadales	M	membrane-bound lytic murein transglycosylase	mltA	-	-	ko:K08304	-	-	-	-	ko00000,ko01000,ko01011	-	GH102	-	3D,MltA
HKD2_k127_1645861_85	1090320.KB900605_gene3223	2.297e-31	129.0	COG2840@1|root,COG2840@2|Bacteria,1RH34@1224|Proteobacteria,2UCM1@28211|Alphaproteobacteria,2K652@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Smr
HKD2_k127_1645861_12	1123267.JONN01000001_gene1375	1.881e-232	732.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K2DF@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_1645861_21	1123267.JONN01000001_gene1374	4.342e-176	560.0	COG0624@1|root,COG0624@2|Bacteria,1MW6G@1224|Proteobacteria,2TT0J@28211|Alphaproteobacteria,2K0C3@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls	dapE	-	3.5.1.18	ko:K01439	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R02734	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_1645861_67	555793.WSK_0159	3.332e-59	223.0	COG3837@1|root,COG3837@2|Bacteria,1R9WZ@1224|Proteobacteria,2U7QQ@28211|Alphaproteobacteria,2K4VJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_1645861_41	1123269.NX02_07160	9.144e-102	335.0	COG0625@1|root,COG0625@2|Bacteria,1PHM1@1224|Proteobacteria,2TTQZ@28211|Alphaproteobacteria,2K0C9@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_N_2,GST_N_3
HKD2_k127_1645861_50	1207055.C100_07220	2.643e-87	308.0	COG0218@1|root,COG0218@2|Bacteria,1MY3Z@1224|Proteobacteria,2U5E5@28211|Alphaproteobacteria,2K0SN@204457|Sphingomonadales	204457|Sphingomonadales	D	Necessary for normal cell division and for the maintenance of normal septation	engB	-	-	ko:K03978	-	-	-	-	ko00000,ko03036	-	-	-	MMR_HSR1
HKD2_k127_1645861_15	1123267.JONN01000001_gene1369	6.834e-213	675.0	COG0706@1|root,COG0706@2|Bacteria,1MV5M@1224|Proteobacteria,2TSTJ@28211|Alphaproteobacteria,2K1E1@204457|Sphingomonadales	204457|Sphingomonadales	U	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins	yidC	-	-	ko:K03217	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044,ko03029	2.A.9	-	-	60KD_IMP,YidC_periplas
HKD2_k127_1645861_82	1090320.KB900605_gene3217	4.838e-33	129.0	COG0759@1|root,COG0759@2|Bacteria,1N6U4@1224|Proteobacteria,2UFKH@28211|Alphaproteobacteria,2K6W4@204457|Sphingomonadales	204457|Sphingomonadales	S	Could be involved in insertion of integral membrane proteins into the membrane	-	-	-	ko:K08998	-	-	-	-	ko00000	-	-	-	Haemolytic
HKD2_k127_1645861_71	1207055.C100_07235	1.252e-53	192.0	COG0594@1|root,COG0594@2|Bacteria,1N6QY@1224|Proteobacteria,2UFAB@28211|Alphaproteobacteria,2K5Y4@204457|Sphingomonadales	204457|Sphingomonadales	J	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme	rnpA	-	3.1.26.5	ko:K03536	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Ribonuclease_P
HKD2_k127_1645861_90	1123267.JONN01000001_gene1365	3.879e-25	109.0	2A3CY@1|root,30RVE@2|Bacteria,1NNPQ@1224|Proteobacteria,2UJZN@28211|Alphaproteobacteria,2K7DT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PGPGW
HKD2_k127_1645861_91	629773.AORY01000005_gene2814	5.722e-20	96.0	COG0028@1|root,COG0028@2|Bacteria,1MWKP@1224|Proteobacteria,2TQK6@28211|Alphaproteobacteria,2K1ZC@204457|Sphingomonadales	204457|Sphingomonadales	EH	Belongs to the TPP enzyme family	-	-	1.2.5.1	ko:K00156	ko00620,map00620	-	R03145	RC00860	ko00000,ko00001,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_1645861_25	1123267.JONN01000001_gene1361	3.857e-151	488.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TVPN@28211|Alphaproteobacteria,2K11M@204457|Sphingomonadales	204457|Sphingomonadales	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_1645861_99	1457250.BBMO01000001_gene1604	3.503e-06	58.0	arCOG02848@1|root,arCOG02848@2157|Archaea,2XYVU@28890|Euryarchaeota,23X7C@183963|Halobacteria	183963|Halobacteria	O	DnaJ-class molecular chaperone	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_1645861_59	1123267.JONN01000001_gene1360	1.963e-77	274.0	COG3773@1|root,COG3773@2|Bacteria,1RE11@1224|Proteobacteria,2U89A@28211|Alphaproteobacteria,2K11T@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell Wall Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
HKD2_k127_1645861_95	1502850.FG91_00251	2.321e-15	87.0	28WVU@1|root,2ZIV5@2|Bacteria,1NGX2@1224|Proteobacteria,2UJJ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2842)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2842
HKD2_k127_1645861_69	266779.Meso_0627	1.772e-56	204.0	COG5649@1|root,COG5649@2|Bacteria,1RGY3@1224|Proteobacteria,2U9AG@28211|Alphaproteobacteria,43PGY@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DU1801)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801
HKD2_k127_1645861_77	1123267.JONN01000001_gene1358	1.073e-43	168.0	COG0212@1|root,COG0212@2|Bacteria,1MZG0@1224|Proteobacteria,2UBY4@28211|Alphaproteobacteria,2K6W9@204457|Sphingomonadales	204457|Sphingomonadales	H	5-formyltetrahydrofolate cyclo-ligase	-	-	6.3.3.2	ko:K01934	ko00670,ko01100,map00670,map01100	-	R02301	RC00183	ko00000,ko00001,ko01000	-	-	-	5-FTHF_cyc-lig
HKD2_k127_1645861_83	1123267.JONN01000001_gene1357	2.822e-32	128.0	COG3027@1|root,COG3027@2|Bacteria,1Q3M7@1224|Proteobacteria,2VACI@28211|Alphaproteobacteria,2K78U@204457|Sphingomonadales	204457|Sphingomonadales	D	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division	-	-	-	ko:K09888	-	-	-	-	ko00000,ko03036	-	-	-	ZapA
HKD2_k127_1645861_4	1123267.JONN01000001_gene1355	1.432e-320	992.0	COG0021@1|root,COG0021@2|Bacteria,1MUEY@1224|Proteobacteria,2TQUX@28211|Alphaproteobacteria,2K0UZ@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the transketolase family	tktA	-	2.2.1.1	ko:K00615	ko00030,ko00710,ko01051,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00710,map01051,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007,M00165,M00167	R01067,R01641,R01830,R06590	RC00032,RC00226,RC00571,RC01560	ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C,Transketolase_N
HKD2_k127_1645861_20	1449076.JOOE01000001_gene1911	3.738e-176	561.0	COG0057@1|root,COG0057@2|Bacteria,1MU93@1224|Proteobacteria,2TR6E@28211|Alphaproteobacteria,2K0GC@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the glyceraldehyde-3-phosphate dehydrogenase family	gapA	GO:0000166,GO:0003674,GO:0003824,GO:0004365,GO:0005488,GO:0008150,GO:0008152,GO:0016491,GO:0016620,GO:0016903,GO:0036094,GO:0043891,GO:0048037,GO:0050662,GO:0051287,GO:0055114,GO:0097159,GO:1901265,GO:1901363	1.2.1.12	ko:K00134	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04066,ko05010,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230,map04066,map05010	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01061	RC00149	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	Gp_dh_C,Gp_dh_N
HKD2_k127_1645861_16	1123267.JONN01000001_gene1353	6.043e-204	640.0	COG0126@1|root,COG0126@2|Bacteria,1MUNU@1224|Proteobacteria,2TSKQ@28211|Alphaproteobacteria,2K0JN@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the phosphoglycerate kinase family	pgk	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	2.7.2.3	ko:K00927	ko00010,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003,M00165,M00166,M00308,M00552	R01512	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGK
HKD2_k127_1645861_70	392499.Swit_2605	3.111e-56	200.0	COG0346@1|root,COG0346@2|Bacteria,1RHD4@1224|Proteobacteria,2UCUY@28211|Alphaproteobacteria,2K4NH@204457|Sphingomonadales	204457|Sphingomonadales	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_1645861_27	314266.SKA58_09876	1.297e-141	455.0	COG3588@1|root,COG3588@2|Bacteria,1MVFK@1224|Proteobacteria,2TU2S@28211|Alphaproteobacteria,2K14P@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate in glycolysis	fbaB	-	4.1.2.13	ko:K01623	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00003,M00165,M00167	R01068,R01070,R01829,R02568	RC00438,RC00439,RC00603,RC00604	ko00000,ko00001,ko00002,ko01000,ko03036,ko04131,ko04147	-	-	-	Glycolytic
HKD2_k127_1645861_45	1123267.JONN01000001_gene1349	6.399e-96	318.0	COG0352@1|root,COG0352@2|Bacteria,1MV42@1224|Proteobacteria,2TSSA@28211|Alphaproteobacteria,2K16H@204457|Sphingomonadales	204457|Sphingomonadales	H	Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP)	thiE	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD2_k127_1645861_64	1248917.ANFX01000037_gene2092	1.27e-63	226.0	COG3751@1|root,COG3751@2|Bacteria,1NG7K@1224|Proteobacteria,2U773@28211|Alphaproteobacteria,2K1IN@204457|Sphingomonadales	204457|Sphingomonadales	O	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	1.14.11.2	ko:K00472	ko00330,ko01100,map00330,map01100	-	R01252	RC00478	ko00000,ko00001,ko01000	-	-	-	2OG-FeII_Oxy_3
HKD2_k127_1645861_49	1120705.FG95_03243	3.606e-90	303.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2K8RV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_1645861_73	1123267.JONN01000001_gene1345	2.884e-52	194.0	COG0739@1|root,COG0739@2|Bacteria,1RK7E@1224|Proteobacteria,2UB7B@28211|Alphaproteobacteria,2K58B@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	ko:K21472	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_M23
HKD2_k127_1645861_40	745310.G432_00145	1.27e-104	341.0	COG0231@1|root,COG0231@2|Bacteria,1MW2J@1224|Proteobacteria,2TUWE@28211|Alphaproteobacteria,2K0HQ@204457|Sphingomonadales	204457|Sphingomonadales	J	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase	efp	-	-	ko:K02356	-	-	-	-	ko00000,ko03012	-	-	-	EFP,EFP_N,Elong-fact-P_C
HKD2_k127_1645861_76	1280944.HY17_06690	8.5e-47	171.0	COG1917@1|root,COG1917@2|Bacteria,1QUA5@1224|Proteobacteria,2UC97@28211|Alphaproteobacteria,43YET@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_1645861_28	1123267.JONN01000001_gene1343	1.448e-139	447.0	COG0483@1|root,COG0483@2|Bacteria,1MUQT@1224|Proteobacteria,2TR06@28211|Alphaproteobacteria,2K0TX@204457|Sphingomonadales	204457|Sphingomonadales	G	Inositol monophosphatase	suhB	-	3.1.3.25	ko:K01092	ko00521,ko00562,ko01100,ko04070,map00521,map00562,map01100,map04070	M00131	R01185,R01186,R01187	RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Inositol_P
HKD2_k127_1645861_96	394221.Mmar10_0020	9.668e-11	73.0	COG1520@1|root,COG3118@1|root,COG1520@2|Bacteria,COG3118@2|Bacteria,1QYPK@1224|Proteobacteria,2TXUQ@28211|Alphaproteobacteria,43Z8J@69657|Hyphomonadaceae	28211|Alphaproteobacteria	O	belongs to the thioredoxin family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1645861_68	1120705.FG95_00590	9.489e-57	200.0	COG0838@1|root,COG0838@2|Bacteria,1RGUT@1224|Proteobacteria,2U72Q@28211|Alphaproteobacteria,2K4KM@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoA	-	1.6.5.3	ko:K00330	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q4
HKD2_k127_1645861_39	1123267.JONN01000001_gene1341	7.07e-105	346.0	COG0377@1|root,COG0377@2|Bacteria,1MUI2@1224|Proteobacteria,2TQK3@28211|Alphaproteobacteria,2K0KE@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoB	-	1.6.5.3	ko:K00331	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q6
HKD2_k127_1645861_42	1123267.JONN01000001_gene1340	3.311e-100	336.0	COG0852@1|root,COG0852@2|Bacteria,1MX4B@1224|Proteobacteria,2TSMT@28211|Alphaproteobacteria,2K0IR@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoC	-	1.6.5.3	ko:K00332	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_30kDa
HKD2_k127_1645861_13	1123267.JONN01000001_gene1339	1.997e-230	719.0	COG0649@1|root,COG0649@2|Bacteria,1MVIN@1224|Proteobacteria,2TQZ0@28211|Alphaproteobacteria,2K0QX@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoD	-	1.6.5.3	ko:K00333	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_49kDa
HKD2_k127_1645861_36	745310.G432_00185	8.915e-111	362.0	COG1905@1|root,COG1905@2|Bacteria,1MWS2@1224|Proteobacteria,2TSEJ@28211|Alphaproteobacteria,2K18U@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH dehydrogenase	nuoE	-	1.6.5.3	ko:K00334	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	2Fe-2S_thioredx
HKD2_k127_1645861_6	1123267.JONN01000001_gene1336	1.821e-263	813.0	COG1894@1|root,COG1894@2|Bacteria,1MV8F@1224|Proteobacteria,2TRAH@28211|Alphaproteobacteria,2JZYB@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain	nuoF	-	1.6.5.3	ko:K00335	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Complex1_51K,NADH_4Fe-4S,SLBB
HKD2_k127_1645861_92	392499.Swit_2989	3.062e-19	98.0	2AGXB@1|root,3175U@2|Bacteria,1NJ5Z@1224|Proteobacteria,2UNJ0@28211|Alphaproteobacteria,2KBFQ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1645861_2	1123267.JONN01000001_gene1333	0.0	1077.0	COG1034@1|root,COG1034@2|Bacteria,1P8MN@1224|Proteobacteria,2TS97@28211|Alphaproteobacteria,2K16X@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH-quinone oxidoreductase	nuoG	-	1.6.5.3	ko:K00336	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer2_4,Molybdopterin,NADH-G_4Fe-4S_3,NADH_dhqG_C
HKD2_k127_1645861_19	392499.Swit_2992	1.58e-185	586.0	COG1005@1|root,COG1005@2|Bacteria,1MU2R@1224|Proteobacteria,2TS09@28211|Alphaproteobacteria,2JZYY@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone	nuoH	-	1.6.5.3	ko:K00337	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADHdh
HKD2_k127_1645861_44	1123267.JONN01000001_gene1331	9.85e-97	318.0	COG1143@1|root,COG1143@2|Bacteria,1MV90@1224|Proteobacteria,2TRFE@28211|Alphaproteobacteria,2K01J@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoI	-	1.6.5.3	ko:K00338	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Fer4
HKD2_k127_1645861_56	1123267.JONN01000001_gene1330	2.144e-80	272.0	COG0839@1|root,COG0839@2|Bacteria,1MWJV@1224|Proteobacteria,2TRB2@28211|Alphaproteobacteria,2JZZS@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the complex I subunit 6 family	nuoJ	-	1.6.5.3	ko:K00339	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q3
HKD2_k127_1645861_80	460265.Mnod_4136	3.329e-42	156.0	COG0713@1|root,COG0713@2|Bacteria,1RH0S@1224|Proteobacteria,2U93P@28211|Alphaproteobacteria,1JV9A@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoK	GO:0003674,GO:0003824,GO:0003954,GO:0008150,GO:0008152,GO:0016491,GO:0016651,GO:0016655,GO:0050136,GO:0055114	1.6.5.3	ko:K00340	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q2
HKD2_k127_1645861_1	1123267.JONN01000001_gene1328	0.0	1088.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2K1DM@204457|Sphingomonadales	204457|Sphingomonadales	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
HKD2_k127_1676977_11	1030157.AFMP01000052_gene186	9.609e-103	341.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TRAP@28211|Alphaproteobacteria,2K0IY@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Sugar_tr
HKD2_k127_1676977_20	290633.GOX1041	1.827e-11	72.0	2B7M6@1|root,33JXJ@2|Bacteria,1N6CD@1224|Proteobacteria,2UWGK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2501)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2501
HKD2_k127_1676977_10	1123267.JONN01000001_gene2467	2.723e-109	357.0	COG0363@1|root,COG0363@2|Bacteria,1R5K6@1224|Proteobacteria,2U5C7@28211|Alphaproteobacteria,2JZZT@204457|Sphingomonadales	204457|Sphingomonadales	G	6-phosphogluconolactonase	pgl	-	3.1.1.31	ko:K01057	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map01100,map01110,map01120,map01130,map01200	M00004,M00006,M00008	R02035	RC00537	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucosamine_iso
HKD2_k127_1676977_18	1007104.SUS17_3329	1.981e-22	106.0	COG0810@1|root,COG0810@2|Bacteria,1NB5F@1224|Proteobacteria,2USI1@28211|Alphaproteobacteria,2K2ZM@204457|Sphingomonadales	204457|Sphingomonadales	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_1676977_21	556268.OFAG_01255	2.986e-06	50.0	COG3729@1|root,COG3729@2|Bacteria,1NH1J@1224|Proteobacteria,2VY5U@28216|Betaproteobacteria,4754J@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Stress-induced bacterial acidophilic repeat motif	-	-	-	ko:K06884	-	-	-	-	ko00000	-	-	-	KGG
HKD2_k127_1676977_9	1382303.JPOM01000001_gene1068	8.172e-116	380.0	COG4705@1|root,COG4705@2|Bacteria,1MVMJ@1224|Proteobacteria,2TS5R@28211|Alphaproteobacteria,2KIFP@204458|Caulobacterales	204458|Caulobacterales	S	Repeat of Unknown Function (DUF347)	-	-	-	-	-	-	-	-	-	-	-	-	DUF347
HKD2_k127_1676977_3	1123267.JONN01000001_gene1482	2.14e-227	724.0	COG4206@1|root,COG4206@2|Bacteria,1R1WX@1224|Proteobacteria,2U0GK@28211|Alphaproteobacteria,2K1DC@204457|Sphingomonadales	204457|Sphingomonadales	H	receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_1676977_5	1123269.NX02_14170	6.836e-168	547.0	COG2831@1|root,COG2831@2|Bacteria,1R6KX@1224|Proteobacteria,2TUEN@28211|Alphaproteobacteria,2K29V@204457|Sphingomonadales	204457|Sphingomonadales	U	COG2831 Hemolysin activation secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	POTRA_2,ShlB
HKD2_k127_1676977_12	1335760.ASTG01000019_gene2754	1.267e-95	358.0	COG3210@1|root,COG3210@2|Bacteria,1R8TG@1224|Proteobacteria,2U41V@28211|Alphaproteobacteria,2K1DN@204457|Sphingomonadales	204457|Sphingomonadales	U	COG3210 Large exoproteins involved in heme utilization or adhesion	-	-	-	-	-	-	-	-	-	-	-	-	Haemagg_act
HKD2_k127_1676977_2	392499.Swit_3192	1.22e-287	918.0	COG0457@1|root,COG4995@1|root,COG0457@2|Bacteria,COG4995@2|Bacteria,1R81Z@1224|Proteobacteria,2U2DW@28211|Alphaproteobacteria,2K1YH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	CHAT
HKD2_k127_1676977_1	1123267.JONN01000001_gene1238	0.0	1205.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,MRJP
HKD2_k127_1676977_13	1123267.JONN01000001_gene1239	1.105e-94	321.0	2C1YS@1|root,2ZD2Y@2|Bacteria	2|Bacteria	S	Protease prsW family	-	-	-	-	-	-	-	-	-	-	-	-	PrsW-protease
HKD2_k127_1676977_4	1123267.JONN01000001_gene703	1.155e-194	617.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2K0P4@204457|Sphingomonadales	204457|Sphingomonadales	M	PFAM Outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_1676977_0	1123267.JONN01000001_gene702	0.0	1762.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales	204457|Sphingomonadales	V	Efflux pump membrane transporter	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_1676977_6	1123267.JONN01000001_gene701	3.071e-163	526.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSWK@28211|Alphaproteobacteria,2K12P@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_1676977_17	1549858.MC45_02665	3.79e-24	108.0	299Z9@1|root,2ZX0X@2|Bacteria,1P9K5@1224|Proteobacteria,2UYGM@28211|Alphaproteobacteria,2K624@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1676977_14	1090320.KB900605_gene2058	4.044e-79	270.0	COG1309@1|root,COG1309@2|Bacteria,1NCEF@1224|Proteobacteria,2TR7K@28211|Alphaproteobacteria,2K2CN@204457|Sphingomonadales	204457|Sphingomonadales	K	TetR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_6,TetR_N
HKD2_k127_1676977_19	392499.Swit_5297	2.516e-13	74.0	COG2346@1|root,COG2346@2|Bacteria,1MZSM@1224|Proteobacteria,2UCHK@28211|Alphaproteobacteria,2K5DI@204457|Sphingomonadales	204457|Sphingomonadales	S	COG2346 Truncated hemoglobins	-	-	-	ko:K06886	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_1676977_8	279238.Saro_2769	3.986e-135	435.0	COG0583@1|root,COG0583@2|Bacteria,1N0HM@1224|Proteobacteria,2U1WV@28211|Alphaproteobacteria,2K1QS@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_1676977_7	279238.Saro_2768	1.651e-155	499.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria,2KAS3@204457|Sphingomonadales	204457|Sphingomonadales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N
HKD2_k127_1676977_15	279238.Saro_2767	7.344e-56	199.0	COG1028@1|root,COG1028@2|Bacteria,1P9R4@1224|Proteobacteria,2TSIF@28211|Alphaproteobacteria,2K209@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_1767365_2	754035.Mesau_00129	1.008e-64	227.0	COG0607@1|root,COG4275@1|root,COG0607@2|Bacteria,COG4275@2|Bacteria,1MYDE@1224|Proteobacteria,2TRC3@28211|Alphaproteobacteria,43IM5@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	P	Chromate resistance exported protein	chrB	-	-	-	-	-	-	-	-	-	-	-	Chrome_Resist,Rhodanese
HKD2_k127_1767365_4	1117943.SFHH103_02748	3.426e-26	112.0	2BQZQ@1|root,32JX2@2|Bacteria,1RJP3@1224|Proteobacteria,2V5ZF@28211|Alphaproteobacteria,4BFCG@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_1767365_1	717785.HYPMC_3224	1.526e-97	323.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Resolvase	-	-	-	ko:K06400	-	-	-	-	ko00000	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_1767365_3	622637.KE124774_gene2146	1.008e-50	185.0	2E7ZA@1|root,332DQ@2|Bacteria,1N8W6@1224|Proteobacteria,2UH44@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2924)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2924
HKD2_k127_1767365_5	717785.HYPMC_3226	2.342e-23	101.0	COG1595@1|root,COG1595@2|Bacteria,1NCTM@1224|Proteobacteria,2VGG6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Protein of unknown function (DUF3489)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3489
HKD2_k127_1767365_0	670307.HYPDE_39838	4.975e-194	613.0	COG0004@1|root,COG0004@2|Bacteria,1NR9F@1224|Proteobacteria,2TT2J@28211|Alphaproteobacteria,3N71B@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	ammonium transporter	-	-	-	ko:K03320	-	-	-	-	ko00000,ko02000	1.A.11	-	-	Ammonium_transp
HKD2_k127_1792044_1	269796.Rru_A0676	1.747e-110	362.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,2JQI5@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase IS116/IS110/IS902 family	-	-	-	ko:K07486	-	-	-	-	ko00000	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_1792044_5	999541.bgla_2g08280	2.312e-48	177.0	2DHGU@1|root,32U97@2|Bacteria,1N48C@1224|Proteobacteria,2W3XJ@28216|Betaproteobacteria	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1792044_9	263358.VAB18032_25905	1.166e-09	67.0	COG1280@1|root,COG1280@2|Bacteria,2IIQ3@201174|Actinobacteria,4DDUC@85008|Micromonosporales	201174|Actinobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD2_k127_1792044_3	1112214.AHIS01000050_gene2389	2.021e-65	231.0	COG5429@1|root,COG5429@2|Bacteria,1MW6R@1224|Proteobacteria,2U33F@28211|Alphaproteobacteria,2K4W4@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1223)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1223
HKD2_k127_1792044_6	1449076.JOOE01000001_gene3008	1.554e-28	120.0	COG5572@1|root,COG5572@2|Bacteria,1MZ6Q@1224|Proteobacteria,2UBV0@28211|Alphaproteobacteria,2K6TQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted integral membrane protein (DUF2282)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2282
HKD2_k127_1792044_4	1346791.M529_00375	7.795e-63	222.0	COG4944@1|root,COG4944@2|Bacteria,1MXEV@1224|Proteobacteria,2TQKY@28211|Alphaproteobacteria,2K1EV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD2_k127_1792044_7	685778.AORL01000019_gene1904	2.716e-27	114.0	2C39R@1|root,32UYY@2|Bacteria,1N19H@1224|Proteobacteria,2UDTU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1792044_0	1449076.JOOE01000001_gene3012	1.847e-112	370.0	COG3220@1|root,COG3220@2|Bacteria,1MURE@1224|Proteobacteria,2TRZJ@28211|Alphaproteobacteria,2K1E6@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0276 family	-	-	-	ko:K09930	-	-	-	-	ko00000	-	-	-	DUF692
HKD2_k127_1792044_2	1123269.NX02_01040	2.331e-66	235.0	COG3219@1|root,COG3219@2|Bacteria,1MZS2@1224|Proteobacteria,2UDEG@28211|Alphaproteobacteria,2K491@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2063
HKD2_k127_1792044_8	331869.BAL199_22482	1.64e-12	74.0	COG0625@1|root,COG0625@2|Bacteria,1Q05U@1224|Proteobacteria	1224|Proteobacteria	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_1811572_0	1038859.AXAU01000001_gene3525	7.452e-106	351.0	2A649@1|root,30UWR@2|Bacteria,1R5WW@1224|Proteobacteria,2U4B5@28211|Alphaproteobacteria,3JVJK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1811572_1	1304878.AUGD01000018_gene1355	2.739e-47	188.0	COG2433@1|root,COG2433@2|Bacteria,1QW6M@1224|Proteobacteria,2TWQ2@28211|Alphaproteobacteria,3JRK5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam Transposase IS66	MA20_46300	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_1819584_2	198628.Dda3937_03090	1.153e-08	59.0	COG0477@1|root,COG2814@2|Bacteria	2|Bacteria	EGP	Major facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_1819584_0	1247963.JPHU01000029_gene93	2.715e-127	413.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	-	-	-	-	-	-	-	-	-	HTH_21,rve,rve_3
HKD2_k127_1819584_1	1089552.KI911559_gene2017	1.745e-39	148.0	COG2963@1|root,COG2963@2|Bacteria,1RGZ5@1224|Proteobacteria,2UAIS@28211|Alphaproteobacteria,2JT7W@204441|Rhodospirillales	204441|Rhodospirillales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD2_k127_1911194_1	113395.AXAI01000012_gene7050	7.046e-155	494.0	COG0679@1|root,COG0679@2|Bacteria,1R54F@1224|Proteobacteria,2U2GM@28211|Alphaproteobacteria,3K5ZG@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Membrane transport protein	-	-	-	ko:K07088	-	-	-	-	ko00000	-	-	-	Mem_trans
HKD2_k127_1911194_0	717785.HYPMC_3257	2.113e-209	659.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3N8ZI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD2_k127_1968704_10	402626.Rpic_3439	2.491e-13	70.0	COG0657@1|root,COG0657@2|Bacteria,1N3TH@1224|Proteobacteria,2W12C@28216|Betaproteobacteria,1KCV0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD2_k127_1968704_8	1245471.PCA10_24070	1.46e-64	239.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1S1G1@1236|Gammaproteobacteria,1YFQK@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	K	Arabinose-binding domain of AraC transcription regulator, N-term	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_1968704_1	398525.KB900701_gene5676	6.383e-173	560.0	COG3246@1|root,COG3246@2|Bacteria,1MXGN@1224|Proteobacteria,2U4WZ@28211|Alphaproteobacteria,3K30S@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	beta-keto acid cleavage enzyme	-	-	-	-	-	-	-	-	-	-	-	-	BKACE
HKD2_k127_1968704_6	398525.KB900701_gene5677	2.535e-99	331.0	COG0599@1|root,COG0599@2|Bacteria,1N0Z6@1224|Proteobacteria,2VGPU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_1968704_2	1123267.JONN01000002_gene318	3.461e-130	419.0	COG3023@1|root,COG3023@2|Bacteria,1RDHU@1224|Proteobacteria,2TSW3@28211|Alphaproteobacteria,2K0W6@204457|Sphingomonadales	204457|Sphingomonadales	V	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01447	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Amidase_2
HKD2_k127_1968704_4	1123267.JONN01000002_gene317	7.678e-127	411.0	COG1352@1|root,COG1352@2|Bacteria,1MU6W@1224|Proteobacteria,2TRQ3@28211|Alphaproteobacteria,2K3X1@204457|Sphingomonadales	204457|Sphingomonadales	NT	COG1352 Methylase of chemotaxis methyl-accepting proteins	cheR	-	2.1.1.80	ko:K00575	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko01000,ko02035	-	-	-	CheR
HKD2_k127_1968704_5	1123267.JONN01000002_gene316	1.442e-120	398.0	COG2201@1|root,COG2201@2|Bacteria,1MWCN@1224|Proteobacteria,2TSGV@28211|Alphaproteobacteria,2K0GS@204457|Sphingomonadales	204457|Sphingomonadales	NT	catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR	cheB	-	3.1.1.61,3.5.1.44	ko:K03412	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko02022,ko02035	-	-	-	CheB_methylest,Response_reg
HKD2_k127_1968704_7	1123267.JONN01000002_gene315	1.446e-69	237.0	COG0745@1|root,COG0745@2|Bacteria,1QU38@1224|Proteobacteria,2TVXD@28211|Alphaproteobacteria,2KEGQ@204457|Sphingomonadales	204457|Sphingomonadales	T	cheY-homologous receiver domain	-	-	-	ko:K03413	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko02022,ko02035	-	-	-	Response_reg
HKD2_k127_1968704_9	1123267.JONN01000002_gene314	9.347e-60	211.0	COG0835@1|root,COG0835@2|Bacteria,1N88R@1224|Proteobacteria,2UGI7@28211|Alphaproteobacteria,2K55G@204457|Sphingomonadales	204457|Sphingomonadales	NT	Two component signalling adaptor domain	-	-	-	ko:K03408	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	CheW
HKD2_k127_1968704_0	1123267.JONN01000002_gene313	0.0	1074.0	COG0643@1|root,COG0643@2|Bacteria,1MUAG@1224|Proteobacteria,2TSN2@28211|Alphaproteobacteria,2K0Z1@204457|Sphingomonadales	204457|Sphingomonadales	NT	chemotaxis protein	cheA	-	2.7.13.3	ko:K03407	ko02020,ko02030,map02020,map02030	M00506	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022,ko02035	-	-	-	CheW,H-kinase_dim,HATPase_c,Hpt
HKD2_k127_1968704_3	745310.G432_16405	2.58e-129	427.0	COG1228@1|root,COG1228@2|Bacteria,1R7HE@1224|Proteobacteria,2VFGS@28211|Alphaproteobacteria,2K5QR@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_2240356_1	517433.PanABDRAFT_0605	6.598e-32	129.0	COG0620@1|root,COG0620@2|Bacteria,1MV2Z@1224|Proteobacteria,1RPTM@1236|Gammaproteobacteria,3VYEN@53335|Pantoea	1236|Gammaproteobacteria	E	Methionine synthase	yxjG	-	2.1.1.14	ko:K00549	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R04405,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	Meth_synt_2
HKD2_k127_2240356_0	935840.JAEQ01000003_gene279	5.43e-204	643.0	COG0404@1|root,COG0404@2|Bacteria,1MWZS@1224|Proteobacteria,2TSVD@28211|Alphaproteobacteria,43JE4@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	E	Aminomethyltransferase folate-binding domain	-	-	2.1.1.341	ko:K15066	ko00627,ko01120,map00627,map01120	-	R09271,R10136	RC00113,RC00392	ko00000,ko00001,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_228392_58	1123267.JONN01000001_gene488	1.591e-22	102.0	COG1670@1|root,COG1670@2|Bacteria,1N6Q1@1224|Proteobacteria,2UG72@28211|Alphaproteobacteria,2K4XG@204457|Sphingomonadales	204457|Sphingomonadales	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_228392_37	317655.Sala_0369	2.7e-96	320.0	COG3826@1|root,COG3826@2|Bacteria,1MWVV@1224|Proteobacteria,2TQMH@28211|Alphaproteobacteria,2K2AB@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09990	-	-	-	-	ko00000	-	-	-	Oxygenase-NA
HKD2_k127_228392_24	1123267.JONN01000001_gene487	1.542e-119	390.0	COG3687@1|root,COG3687@2|Bacteria,1MWGV@1224|Proteobacteria,2U1DK@28211|Alphaproteobacteria,2K0CB@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted metal-dependent hydrolase	-	-	-	ko:K07044	-	-	-	-	ko00000	-	-	-	Metal_hydrol
HKD2_k127_228392_46	1123269.NX02_27585	7.206e-65	227.0	COG1309@1|root,COG1309@2|Bacteria,1N2ZP@1224|Proteobacteria,2UC9P@28211|Alphaproteobacteria,2K4HW@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_228392_51	279238.Saro_1697	7.124e-49	179.0	COG5478@1|root,COG5478@2|Bacteria,1MZMZ@1224|Proteobacteria,2UBR2@28211|Alphaproteobacteria,2K5A3@204457|Sphingomonadales	204457|Sphingomonadales	S	small integral membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD2_k127_228392_15	685778.AORL01000010_gene2835	9.018e-158	503.0	COG0536@1|root,COG0536@2|Bacteria,1MUGZ@1224|Proteobacteria,2TR5I@28211|Alphaproteobacteria,2K1GJ@204457|Sphingomonadales	204457|Sphingomonadales	S	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control	obg	-	-	ko:K03979	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	GTP1_OBG,MMR_HSR1
HKD2_k127_228392_30	1123267.JONN01000001_gene1473	1.765e-111	367.0	COG0702@1|root,COG0702@2|Bacteria,1RCCP@1224|Proteobacteria,2TU1D@28211|Alphaproteobacteria,2K0TF@204457|Sphingomonadales	204457|Sphingomonadales	GM	epimerase	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_10
HKD2_k127_228392_8	392499.Swit_3968	8.067e-213	681.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PilZ
HKD2_k127_228392_57	685778.AORL01000010_gene2832	1.714e-32	130.0	COG0236@1|root,COG0236@2|Bacteria,1NHQD@1224|Proteobacteria,2UGSG@28211|Alphaproteobacteria,2K5YB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	acyl carrier protein	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_228392_7	1123270.ATUR01000002_gene2637	4.236e-226	704.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TQYP@28211|Alphaproteobacteria,2K0V8@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0156 7-keto-8-aminopelargonate synthetase and related enzymes	-	-	2.3.1.29,2.3.1.47	ko:K00639,ko:K00652	ko00260,ko00780,ko01100,map00260,map00780,map01100	M00123,M00573,M00577	R00371,R03210,R10124	RC00004,RC00039,RC00394,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_228392_6	1123267.JONN01000001_gene431	8.906e-234	740.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,HATPase_c,HisKA,Response_reg
HKD2_k127_228392_35	1331060.RLDS_17215	9.038e-101	337.0	COG3153@1|root,COG3153@2|Bacteria,1QURI@1224|Proteobacteria,2TSFI@28211|Alphaproteobacteria,2KEAP@204457|Sphingomonadales	204457|Sphingomonadales	S	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_228392_21	1123267.JONN01000001_gene424	9.648e-123	405.0	COG1597@1|root,COG1597@2|Bacteria,1R78V@1224|Proteobacteria,2U0V0@28211|Alphaproteobacteria,2K03G@204457|Sphingomonadales	204457|Sphingomonadales	I	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_228392_17	1123267.JONN01000001_gene423	2.644e-155	501.0	COG0795@1|root,COG0795@2|Bacteria,1MUF2@1224|Proteobacteria,2U55Q@28211|Alphaproteobacteria,2K07C@204457|Sphingomonadales	204457|Sphingomonadales	S	YjgP YjgQ family	-	-	-	ko:K07091	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD2_k127_228392_20	1123267.JONN01000001_gene422	1.475e-126	415.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,2K1ZM@204457|Sphingomonadales	204457|Sphingomonadales	S	YjgP YjgQ family	-	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD2_k127_228392_52	1123267.JONN01000001_gene951	6.53e-46	167.0	2C82G@1|root,32RK9@2|Bacteria,1MZV5@1224|Proteobacteria,2UCEY@28211|Alphaproteobacteria,2K7ZX@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF4242)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4242
HKD2_k127_228392_33	1057002.KB905370_gene2611	6.947e-107	369.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
HKD2_k127_228392_36	342113.DM82_1715	3.015e-100	332.0	COG4312@1|root,COG4312@2|Bacteria,1NAXN@1224|Proteobacteria,2VPP0@28216|Betaproteobacteria,1K047@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Bacterial protein of unknown function (DUF899)	-	-	-	-	-	-	-	-	-	-	-	-	DUF899
HKD2_k127_228392_54	1449076.JOOE01000003_gene3772	2.003e-42	161.0	COG3832@1|root,COG3832@2|Bacteria,1RHJJ@1224|Proteobacteria,2U6I2@28211|Alphaproteobacteria,2K7CQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Activator of Hsp90 ATPase homolog 1-like protein	-	-	-	-	-	-	-	-	-	-	-	-	AHSA1
HKD2_k127_228392_53	1449076.JOOE01000003_gene3769	3.084e-44	163.0	COG0640@1|root,COG0640@2|Bacteria,1RH5P@1224|Proteobacteria,2U960@28211|Alphaproteobacteria,2KD85@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, Arsenical Resistance Operon Repressor	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20
HKD2_k127_228392_49	13689.BV96_02354	1.173e-51	188.0	2ADQJ@1|root,313FX@2|Bacteria,1MYNR@1224|Proteobacteria,2UCQS@28211|Alphaproteobacteria,2K5ZN@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_228392_14	1287276.X752_22115	6.132e-159	511.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TUXP@28211|Alphaproteobacteria,43N4R@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	G	beta-glucosidase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_42,Glycos_transf_1
HKD2_k127_228392_23	317655.Sala_0737	1.404e-120	398.0	COG3507@1|root,COG3507@2|Bacteria,1R3V6@1224|Proteobacteria,2UFF1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	3.2.1.99	ko:K06113	-	-	-	-	ko00000,ko01000	-	GH43	-	Glyco_hydro_43
HKD2_k127_228392_63	494419.ALPM01000024_gene258	3.857e-07	62.0	COG0484@1|root,COG0484@2|Bacteria,2IDAA@201174|Actinobacteria,1W86U@1268|Micrococcaceae	201174|Actinobacteria	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_228392_3	1089551.KE386572_gene4516	1.799e-270	857.0	COG4993@1|root,COG4993@2|Bacteria,1MUQX@1224|Proteobacteria,2TQMV@28211|Alphaproteobacteria,4BQR9@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	G	PQQ-like domain	gcd	GO:0000287,GO:0003674,GO:0003824,GO:0004344,GO:0005488,GO:0005575,GO:0005623,GO:0005886,GO:0008150,GO:0008152,GO:0008876,GO:0016020,GO:0016021,GO:0016491,GO:0016614,GO:0016901,GO:0019842,GO:0031224,GO:0031406,GO:0036094,GO:0043167,GO:0043168,GO:0043169,GO:0043177,GO:0044425,GO:0044464,GO:0046872,GO:0048037,GO:0048038,GO:0048039,GO:0055114,GO:0070968,GO:0071944,GO:0097159,GO:1901363	1.1.5.2	ko:K00117	ko00030,ko01100,ko01110,ko01130,map00030,map01100,map01110,map01130	-	R06620	RC00066	ko00000,ko00001,ko01000	-	-	-	PQQ,PQQ_2
HKD2_k127_228392_59	1112212.JH584235_gene1551	5.56e-16	81.0	2EJQP@1|root,33DFH@2|Bacteria,1NI6C@1224|Proteobacteria,2UMF9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HIPIP
HKD2_k127_228392_16	1122612.AUBA01000003_gene1661	3.984e-156	506.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2U822@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_228392_9	1123267.JONN01000001_gene1754	2.099e-198	621.0	COG0202@1|root,COG0202@2|Bacteria,1MU75@1224|Proteobacteria,2TSI0@28211|Alphaproteobacteria,2K0R2@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoA	-	2.7.7.6	ko:K03040	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_A_CTD,RNA_pol_A_bac,RNA_pol_L
HKD2_k127_228392_44	1123267.JONN01000001_gene1753	6.712e-73	246.0	COG0100@1|root,COG0100@2|Bacteria,1RD0A@1224|Proteobacteria,2U717@28211|Alphaproteobacteria,2K3VT@204457|Sphingomonadales	204457|Sphingomonadales	J	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome	rpsK	-	-	ko:K02948	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S11
HKD2_k127_228392_47	264203.ZMO0539	5.969e-61	216.0	COG0099@1|root,COG0099@2|Bacteria,1RD1G@1224|Proteobacteria,2U73D@28211|Alphaproteobacteria,2K4E3@204457|Sphingomonadales	204457|Sphingomonadales	J	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits	rpsM	-	-	ko:K02952	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S13
HKD2_k127_228392_55	1320556.AVBP01000001_gene4425	2.003e-36	142.0	COG4331@1|root,COG4331@2|Bacteria,1RGSA@1224|Proteobacteria,2U713@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2127)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2127
HKD2_k127_228392_31	1219049.SP5_072_00070	3.393e-110	365.0	COG0196@1|root,COG0196@2|Bacteria,1MV9I@1224|Proteobacteria,2TTUY@28211|Alphaproteobacteria,2K0M2@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the ribF family	ribF	-	2.7.1.26,2.7.7.2	ko:K11753	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00161,R00549	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_syn,Flavokinase
HKD2_k127_228392_0	1174684.EBMC1_03909	0.0	1404.0	COG0060@1|root,COG0060@2|Bacteria,1MVBQ@1224|Proteobacteria,2TR3N@28211|Alphaproteobacteria,2K0GR@204457|Sphingomonadales	204457|Sphingomonadales	J	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)	ileS	-	6.1.1.5	ko:K01870	ko00970,map00970	M00359,M00360	R03656	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1,zf-FPG_IleRS
HKD2_k127_228392_48	1090318.ATTI01000001_gene517	4.379e-56	208.0	COG0597@1|root,COG0597@2|Bacteria,1RGV9@1224|Proteobacteria,2UBUC@28211|Alphaproteobacteria,2K4K3@204457|Sphingomonadales	204457|Sphingomonadales	MU	This protein specifically catalyzes the removal of signal peptides from prolipoproteins	lspA	-	3.4.23.36	ko:K03101	ko03060,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_A8
HKD2_k127_228392_56	1123267.JONN01000001_gene1748	1.157e-34	137.0	2C068@1|root,30N9J@2|Bacteria,1RG08@1224|Proteobacteria,2U9FG@28211|Alphaproteobacteria,2K56D@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3035)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3035
HKD2_k127_228392_41	1123267.JONN01000001_gene1747	3.248e-82	276.0	COG0745@1|root,COG0745@2|Bacteria	1123267.JONN01000001_gene1747|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_228392_34	1123267.JONN01000001_gene1745	1.017e-103	344.0	COG2897@1|root,COG2897@2|Bacteria,1MW4B@1224|Proteobacteria,2TR9R@28211|Alphaproteobacteria,2K1GF@204457|Sphingomonadales	204457|Sphingomonadales	P	Catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds	sseA	-	2.8.1.1,2.8.1.2	ko:K01011	ko00270,ko00920,ko01100,ko01120,ko04122,map00270,map00920,map01100,map01120,map04122	-	R01931,R03105,R03106	RC00214	ko00000,ko00001,ko01000	-	-	-	Rhodanese
HKD2_k127_228392_32	194867.ALBQ01000053_gene1809	4.193e-110	362.0	COG0692@1|root,COG0692@2|Bacteria,1MV80@1224|Proteobacteria,2U1VI@28211|Alphaproteobacteria,2K0CQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine	ung	-	3.2.2.27	ko:K03648	ko03410,ko05340,map03410,map05340	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_228392_39	1123267.JONN01000001_gene1744	3.085e-85	283.0	COG0780@1|root,COG0780@2|Bacteria,1MW0M@1224|Proteobacteria,2U57X@28211|Alphaproteobacteria,2K3W2@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily	queF	-	1.7.1.13	ko:K09457	ko00790,ko01100,map00790,map01100	-	R07605	RC01875	ko00000,ko00001,ko01000,ko03016	-	-	-	QueF
HKD2_k127_228392_43	1122951.ATUE01000006_gene1049	4.187e-77	271.0	COG1893@1|root,COG1893@2|Bacteria,1N0M5@1224|Proteobacteria,1RNZY@1236|Gammaproteobacteria,3NM1M@468|Moraxellaceae	1236|Gammaproteobacteria	H	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid	-	-	1.1.1.169	ko:K00077	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R02472	RC00726	ko00000,ko00001,ko00002,ko01000	-	-	-	ApbA,ApbA_C
HKD2_k127_228392_4	1114964.L485_14165	8.588e-268	839.0	COG1297@1|root,COG1297@2|Bacteria,1N7SK@1224|Proteobacteria,2TRCZ@28211|Alphaproteobacteria,2K1RU@204457|Sphingomonadales	204457|Sphingomonadales	S	Transporter	-	-	-	-	-	-	-	-	-	-	-	-	OPT
HKD2_k127_228392_60	745310.G432_09745	5.587e-16	87.0	2AI6K@1|root,318KX@2|Bacteria,1P1HA@1224|Proteobacteria,2UV4H@28211|Alphaproteobacteria,2K74P@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_228392_12	745310.G432_09735	3.786e-178	573.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,2TQPZ@28211|Alphaproteobacteria,2K08H@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S1C family	-	-	3.4.21.107	ko:K04771	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ_2,Trypsin_2
HKD2_k127_228392_29	1123267.JONN01000001_gene414	2.459e-115	380.0	COG0330@1|root,COG0330@2|Bacteria,1MV7R@1224|Proteobacteria,2TRP4@28211|Alphaproteobacteria,2K1HR@204457|Sphingomonadales	204457|Sphingomonadales	O	HflC and HflK could regulate a protease	hflC	-	-	ko:K04087	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD2_k127_228392_27	13689.BV96_02426	4.935e-116	392.0	COG0330@1|root,COG0330@2|Bacteria,1MUM2@1224|Proteobacteria,2TRTP@28211|Alphaproteobacteria,2K20N@204457|Sphingomonadales	204457|Sphingomonadales	O	HflC and HflK could encode or regulate a protease	hflK	-	-	ko:K04088	-	M00742	-	-	ko00000,ko00002,ko01000	-	-	-	Band_7
HKD2_k127_228392_26	1123267.JONN01000001_gene416	1.299e-116	383.0	COG0489@1|root,COG0489@2|Bacteria,1MU7R@1224|Proteobacteria,2TRDM@28211|Alphaproteobacteria,2K1RH@204457|Sphingomonadales	204457|Sphingomonadales	D	Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP	-	-	-	ko:K03593	-	-	-	-	ko00000,ko03029,ko03036	-	-	-	ParA
HKD2_k127_228392_45	745310.G432_09715	6.837e-66	227.0	COG1832@1|root,COG1832@2|Bacteria,1N03D@1224|Proteobacteria,2TUIY@28211|Alphaproteobacteria,2K4FQ@204457|Sphingomonadales	204457|Sphingomonadales	S	CoA binding domain	-	-	-	ko:K06929	-	-	-	-	ko00000	-	-	-	CoA_binding_2
HKD2_k127_228392_13	1030157.AFMP01000043_gene1680	1.095e-163	526.0	COG0312@1|root,COG0312@2|Bacteria,1MUVW@1224|Proteobacteria,2TSAV@28211|Alphaproteobacteria,2K048@204457|Sphingomonadales	204457|Sphingomonadales	S	modulator of DNA gyrase	pmbA	-	-	ko:K03592	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_228392_22	1123267.JONN01000001_gene419	4.542e-122	400.0	COG0382@1|root,COG0382@2|Bacteria,1MV4Q@1224|Proteobacteria,2TT3I@28211|Alphaproteobacteria,2K0XU@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate	ubiA	-	2.5.1.39	ko:K03179	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R05000,R05615	RC00209,RC02895	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	UbiA
HKD2_k127_228392_40	1123267.JONN01000001_gene1836	1.402e-83	284.0	COG1385@1|root,COG1385@2|Bacteria,1MXCU@1224|Proteobacteria,2TS0N@28211|Alphaproteobacteria,2K0TB@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit	rsmE	-	2.1.1.193	ko:K09761	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_RNA
HKD2_k127_228392_5	1123267.JONN01000001_gene1837	4.414e-248	770.0	COG3572@1|root,COG3572@2|Bacteria,1MU47@1224|Proteobacteria,2TRPT@28211|Alphaproteobacteria,2K1IW@204457|Sphingomonadales	204457|Sphingomonadales	H	glutamate--cysteine ligase	-	-	6.3.2.2	ko:K01919	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00894,R10993	RC00064,RC00090	ko00000,ko00001,ko00002,ko01000	-	-	-	GCS2
HKD2_k127_228392_18	1120792.JAFV01000001_gene3721	1.642e-138	449.0	COG2267@1|root,COG2267@2|Bacteria,1QU3E@1224|Proteobacteria,2TVXS@28211|Alphaproteobacteria,36XS6@31993|Methylocystaceae	28211|Alphaproteobacteria	I	Serine aminopeptidase, S33	pipch2	-	3.4.11.5	ko:K01259	ko00330,map00330	-	R00135	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Abhydrolase_1
HKD2_k127_228392_10	1449076.JOOE01000001_gene2245	9.461e-191	605.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K2WX@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD2_k127_228392_2	1123267.JONN01000001_gene1480	1.381e-305	958.0	COG2366@1|root,COG2366@2|Bacteria,1MVMH@1224|Proteobacteria,2TS4D@28211|Alphaproteobacteria,2K1S8@204457|Sphingomonadales	204457|Sphingomonadales	S	COG2366 Protein related to penicillin acylase	-	-	-	-	-	-	-	-	-	-	-	-	Penicil_amidase
HKD2_k127_228392_1	1123267.JONN01000001_gene1839	0.0	1208.0	COG1793@1|root,COG3285@1|root,COG1793@2|Bacteria,COG3285@2|Bacteria,1MVWY@1224|Proteobacteria,2TRSZ@28211|Alphaproteobacteria,2K046@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA ligase	-	-	6.5.1.1	ko:K01971	ko03450,map03450	-	R00381	RC00005	ko00000,ko00001,ko01000,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,LigD_N
HKD2_k127_228392_19	1123267.JONN01000001_gene1840	5.294e-132	427.0	COG1273@1|root,COG1273@2|Bacteria,1N4UX@1224|Proteobacteria,2TRTI@28211|Alphaproteobacteria,2K1JG@204457|Sphingomonadales	204457|Sphingomonadales	L	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD	ku	-	-	ko:K10979	ko03450,map03450	-	-	-	ko00000,ko00001,ko03400	-	-	-	Ku
HKD2_k127_228392_42	1123267.JONN01000001_gene2363	1.376e-78	273.0	COG0159@1|root,COG0159@2|Bacteria,1MXJV@1224|Proteobacteria,2TQN2@28211|Alphaproteobacteria,2K0XH@204457|Sphingomonadales	204457|Sphingomonadales	E	The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate	trpA	-	4.2.1.20	ko:K01695	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_syntA
HKD2_k127_228392_11	1123267.JONN01000001_gene2362	5.329e-185	584.0	COG0133@1|root,COG0133@2|Bacteria,1MUS8@1224|Proteobacteria,2TSHK@28211|Alphaproteobacteria,2K1IA@204457|Sphingomonadales	204457|Sphingomonadales	E	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine	trpB	-	4.2.1.20	ko:K01696	ko00260,ko00400,ko01100,ko01110,ko01130,ko01230,map00260,map00400,map01100,map01110,map01130,map01230	M00023	R00674,R02340,R02722	RC00209,RC00210,RC00700,RC00701,RC02868	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_228392_25	1254432.SCE1572_07855	6.663e-119	398.0	COG0134@1|root,COG0135@1|root,COG0134@2|Bacteria,COG0135@2|Bacteria,1MW5K@1224|Proteobacteria,42MAG@68525|delta/epsilon subdivisions,2WM94@28221|Deltaproteobacteria,2YV8U@29|Myxococcales	28221|Deltaproteobacteria	E	Belongs to the TrpC family	trpC	-	4.1.1.48,5.3.1.24	ko:K01609,ko:K13498	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R03508,R03509	RC00944,RC00945	ko00000,ko00001,ko00002,ko01000	-	-	iAF987.Gmet_2494	IGPS
HKD2_k127_228392_28	1123267.JONN01000001_gene2360	5.129e-116	383.0	COG0547@1|root,COG0547@2|Bacteria,1MUPV@1224|Proteobacteria,2TR8S@28211|Alphaproteobacteria,2K11A@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)	trpD	-	2.4.2.18	ko:K00766	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00023	R01073	RC00440	ko00000,ko00001,ko00002,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3
HKD2_k127_228392_38	702113.PP1Y_AT3268	4.828e-95	316.0	COG5654@1|root,COG5654@2|Bacteria,1N5WH@1224|Proteobacteria,2U4CY@28211|Alphaproteobacteria,2K0WX@204457|Sphingomonadales	204457|Sphingomonadales	S	RES domain	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD2_k127_228392_50	13689.BV96_03047	3.821e-50	181.0	COG5606@1|root,COG5606@2|Bacteria,1QUS2@1224|Proteobacteria	1224|Proteobacteria	S	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HKD2_k127_228392_62	1410668.JNKC01000016_gene993	3.344e-07	55.0	2DES4@1|root,2ZP1M@2|Bacteria,1W3CF@1239|Firmicutes	1239|Firmicutes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_79	190650.CC_2380	1.719e-05	46.0	COG0438@1|root,COG0438@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glycos_transf_1
HKD2_k127_2304178_48	1123267.JONN01000001_gene837	2.504e-59	212.0	COG2518@1|root,COG2518@2|Bacteria,1RD6S@1224|Proteobacteria,2U704@28211|Alphaproteobacteria,2K2P0@204457|Sphingomonadales	204457|Sphingomonadales	O	protein-L-isoaspartate	-	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_2304178_14	1123267.JONN01000001_gene838	4.04e-178	574.0	COG1538@1|root,COG1538@2|Bacteria,1MWCJ@1224|Proteobacteria,2TR3S@28211|Alphaproteobacteria,2JZY5@204457|Sphingomonadales	204457|Sphingomonadales	MU	membrane	-	-	-	ko:K12340	ko01501,ko01503,ko02020,ko03070,ko04626,ko05133,map01501,map01503,map02020,map03070,map04626,map05133	M00325,M00326,M00339,M00571,M00575,M00646,M00647,M00696,M00697,M00709,M00720,M00821	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko02044	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_2304178_59	1123267.JONN01000001_gene839	1.761e-36	142.0	COG3827@1|root,COG3827@2|Bacteria,1MX61@1224|Proteobacteria,2TSG8@28211|Alphaproteobacteria,2K7EP@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09991	-	-	-	-	ko00000	-	-	-	DUF2497
HKD2_k127_2304178_2	1123267.JONN01000001_gene840	1.4e-322	999.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TUXY@28211|Alphaproteobacteria,2K16Q@204457|Sphingomonadales	204457|Sphingomonadales	EU	peptidase S9	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_2304178_0	1123267.JONN01000001_gene841	0.0	1335.0	COG0525@1|root,COG0525@2|Bacteria,1MV7B@1224|Proteobacteria,2TS9E@28211|Alphaproteobacteria,2K0N3@204457|Sphingomonadales	204457|Sphingomonadales	J	amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner	valS	-	6.1.1.9	ko:K01873	ko00970,map00970	M00359,M00360	R03665	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,Val_tRNA-synt_C,tRNA-synt_1
HKD2_k127_2304178_11	1234595.C725_1622	1.673e-187	599.0	COG0534@1|root,COG0534@2|Bacteria,1MVRV@1224|Proteobacteria,2U34G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	Mate efflux family protein	-	-	-	-	-	-	-	-	-	-	-	-	MatE
HKD2_k127_2304178_19	1123267.JONN01000001_gene844	1.403e-161	513.0	COG0113@1|root,COG0113@2|Bacteria,1MWMW@1224|Proteobacteria,2TS3F@28211|Alphaproteobacteria,2K011@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the ALAD family	hemB	-	4.2.1.24	ko:K01698	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00036	RC00918,RC01781	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ALAD
HKD2_k127_2304178_31	984262.SGRA_2370	2.127e-117	394.0	COG0076@1|root,COG0076@2|Bacteria,4NGZB@976|Bacteroidetes	976|Bacteroidetes	E	Pyridoxal-dependent decarboxylase conserved domain	-	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD2_k127_2304178_50	383381.EH30_15175	5.508e-58	207.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,2U97G@28211|Alphaproteobacteria,2K59G@204457|Sphingomonadales	204457|Sphingomonadales	J	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_2304178_61	1123267.JONN01000001_gene846	2.708e-28	120.0	2BQ8X@1|root,32J3R@2|Bacteria,1Q8FJ@1224|Proteobacteria,2VENE@28211|Alphaproteobacteria,2K85W@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_75	1267005.KB911255_gene2387	1.483e-10	63.0	COG1961@1|root,COG1961@2|Bacteria,1PWCY@1224|Proteobacteria,2TVME@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_2304178_43	1038859.AXAU01000001_gene3809	4.744e-78	264.0	COG5654@1|root,COG5654@2|Bacteria,1N6P3@1224|Proteobacteria,2U76F@28211|Alphaproteobacteria,3K5UA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD2_k127_2304178_56	1207055.C100_12210	1.167e-38	149.0	COG5642@1|root,COG5642@2|Bacteria,1RK9F@1224|Proteobacteria,2UA8G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF2384)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HKD2_k127_2304178_38	666685.R2APBS1_2528	5.684e-91	307.0	2A1SN@1|root,30Q1C@2|Bacteria,1NXN6@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_77	1211777.BN77_1663	1.864e-08	59.0	2DTVP@1|root,33MV8@2|Bacteria,1NKRP@1224|Proteobacteria,2UK5K@28211|Alphaproteobacteria,4BHMS@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_35	1114964.L485_08985	1.01e-94	317.0	COG0664@1|root,COG0664@2|Bacteria,1NUXB@1224|Proteobacteria,2URDT@28211|Alphaproteobacteria,2KCW1@204457|Sphingomonadales	204457|Sphingomonadales	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_2304178_64	1123267.JONN01000001_gene875	1.518e-24	105.0	29188@1|root,2ZNVC@2|Bacteria,1NM5D@1224|Proteobacteria,2UMZG@28211|Alphaproteobacteria,2K7SH@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_68	1248760.ANFZ01000006_gene2737	2.18e-21	97.0	2A2WM@1|root,30RAQ@2|Bacteria,1NC0Y@1224|Proteobacteria,2UGYZ@28211|Alphaproteobacteria,2K6WP@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_13	1123267.JONN01000001_gene955	1.843e-185	599.0	COG3724@1|root,COG3724@2|Bacteria,1MUJV@1224|Proteobacteria,2U0HD@28211|Alphaproteobacteria,2K01P@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2)	astB	-	3.5.3.23	ko:K01484	ko00330,ko01100,map00330,map01100	-	R04189	RC00024	ko00000,ko00001,ko01000	-	-	-	AstB
HKD2_k127_2304178_21	1123267.JONN01000001_gene956	1.532e-159	511.0	COG3138@1|root,COG3138@2|Bacteria,1MWHC@1224|Proteobacteria,2TREF@28211|Alphaproteobacteria,2K0MB@204457|Sphingomonadales	204457|Sphingomonadales	E	arginine N-succinyltransferase	astA	-	2.3.1.109	ko:K00673	ko00330,ko01100,map00330,map01100	-	R00832	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	AstA
HKD2_k127_2304178_18	1081640.AGFU01000061_gene220	8.224e-164	524.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TRTW@28211|Alphaproteobacteria,2K0AC@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0624 Acetylornithine deacetylase Succinyl-diaminopimelate desuccinylase and related deacylases	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_2304178_27	1123269.NX02_11720	3.823e-130	430.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TR1W@28211|Alphaproteobacteria,2JZYK@204457|Sphingomonadales	204457|Sphingomonadales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_2304178_3	392499.Swit_0037	3.625e-318	990.0	COG0855@1|root,COG0855@2|Bacteria,1MUM3@1224|Proteobacteria,2TRBP@28211|Alphaproteobacteria,2K167@204457|Sphingomonadales	204457|Sphingomonadales	P	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)	ppk	-	2.7.4.1	ko:K00937	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PP_kinase,PP_kinase_C,PP_kinase_N
HKD2_k127_2304178_73	1381123.AYOD01000035_gene3425	1.197e-14	79.0	COG0784@1|root,COG0784@2|Bacteria,1N0E7@1224|Proteobacteria,2UC0P@28211|Alphaproteobacteria,43M30@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_2304178_67	190650.CC_0818	2.715e-22	104.0	2EH9H@1|root,33B1D@2|Bacteria,1NV7J@1224|Proteobacteria,2UXUY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_52	595537.Varpa_2150	2.32e-51	186.0	COG2030@1|root,COG2030@2|Bacteria,1RGUP@1224|Proteobacteria,2VRWK@28216|Betaproteobacteria,4AE33@80864|Comamonadaceae	28216|Betaproteobacteria	I	PFAM MaoC domain protein dehydratase	maoC	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_2304178_70	158500.BV97_02437	2.903e-18	91.0	COG5455@1|root,COG5455@2|Bacteria,1N92K@1224|Proteobacteria,2UHG8@28211|Alphaproteobacteria,2K55J@204457|Sphingomonadales	204457|Sphingomonadales	S	Nickel/cobalt transporter regulator	-	-	-	-	-	-	-	-	-	-	-	-	DUF1090,RcnB
HKD2_k127_2304178_41	1123267.JONN01000001_gene897	2.458e-79	266.0	COG1051@1|root,COG1051@2|Bacteria,1QU0T@1224|Proteobacteria,2TW25@28211|Alphaproteobacteria,2K4S3@204457|Sphingomonadales	204457|Sphingomonadales	F	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage	nudH	-	-	ko:K08311	ko03018,map03018	-	R10816	RC00002	ko00000,ko00001,ko01000,ko03019	-	-	-	NUDIX
HKD2_k127_2304178_1	1123267.JONN01000001_gene900	0.0	1054.0	COG0674@1|root,COG1014@1|root,COG0674@2|Bacteria,COG1014@2|Bacteria,1NBSJ@1224|Proteobacteria,2TU21@28211|Alphaproteobacteria,2K2JW@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1014 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, gamma subunit	-	-	1.2.7.11,1.2.7.3	ko:K00174	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	PFOR_II,POR,POR_N
HKD2_k127_2304178_12	1123267.JONN01000001_gene902	5.937e-187	589.0	COG1013@1|root,COG1013@2|Bacteria,1R5BF@1224|Proteobacteria,2TR4R@28211|Alphaproteobacteria,2K1JI@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1013 Pyruvate ferredoxin oxidoreductase and related 2-oxoacid ferredoxin oxidoreductases, beta subunit	-	-	1.2.7.11,1.2.7.3	ko:K00175	ko00010,ko00020,ko00620,ko00650,ko00720,ko01100,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00650,map00720,map01100,map01120,map01130,map01200	M00009,M00011,M00173,M00620	R01196,R01197	RC00004,RC02742,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C
HKD2_k127_2304178_32	1123267.JONN01000001_gene904	7.529e-115	378.0	COG1988@1|root,COG1988@2|Bacteria,1RA9E@1224|Proteobacteria,2U5TK@28211|Alphaproteobacteria,2K3A3@204457|Sphingomonadales	204457|Sphingomonadales	S	LexA-binding, inner membrane-associated putative hydrolase	-	-	-	ko:K07038	-	-	-	-	ko00000	-	-	-	YdjM
HKD2_k127_2304178_16	1123267.JONN01000001_gene906	1.502e-177	564.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,2K1IB@204457|Sphingomonadales	204457|Sphingomonadales	M	synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD2_k127_2304178_49	1096930.L284_22810	3.563e-59	210.0	COG3871@1|root,COG3871@2|Bacteria,1RI2W@1224|Proteobacteria,2U9IM@28211|Alphaproteobacteria,2K4UQ@204457|Sphingomonadales	204457|Sphingomonadales	S	stress protein (general stress protein 26)	-	-	-	-	-	-	-	-	-	-	-	-	Pyrid_ox_like
HKD2_k127_2304178_66	1449076.JOOE01000002_gene991	2.121e-22	100.0	2AEQ4@1|root,314KE@2|Bacteria,1P2CX@1224|Proteobacteria,2UUQX@28211|Alphaproteobacteria,2KBHE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_63	279238.Saro_3496	8.504e-27	114.0	2E40T@1|root,32YXK@2|Bacteria,1N95U@1224|Proteobacteria,2UK20@28211|Alphaproteobacteria,2KBD2@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_69	1449076.JOOE01000002_gene993	1.072e-20	96.0	2C12A@1|root,33B7C@2|Bacteria,1NMUW@1224|Proteobacteria,2UKV3@28211|Alphaproteobacteria,2KC7F@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_36	1346791.M529_21135	1.399e-92	309.0	COG0300@1|root,COG0300@2|Bacteria,1QUNR@1224|Proteobacteria,2TW24@28211|Alphaproteobacteria,2K1AC@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_2304178_5	1123267.JONN01000002_gene150	1.462e-259	805.0	COG0034@1|root,COG0034@2|Bacteria,1MU0V@1224|Proteobacteria,2TR8V@28211|Alphaproteobacteria,2K0C0@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine	purF	-	2.4.2.14	ko:K00764	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048	R01072	RC00010,RC02724,RC02752	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase_7,Pribosyltran
HKD2_k127_2304178_45	1123267.JONN01000001_gene1606	8.015e-73	252.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2TTDD@28211|Alphaproteobacteria,2K3XP@204457|Sphingomonadales	204457|Sphingomonadales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA_1	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_2304178_4	1123267.JONN01000002_gene152	5.154e-280	871.0	COG1960@1|root,COG1960@2|Bacteria,1MU20@1224|Proteobacteria,2TQJS@28211|Alphaproteobacteria,2K0RG@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_C,Acyl-CoA_dh_M,Acyl-CoA_dh_N,AcylCoA_DH_N
HKD2_k127_2304178_51	13689.BV96_04088	1.989e-53	201.0	COG0664@1|root,COG0664@2|Bacteria,1NSTH@1224|Proteobacteria,2UPDW@28211|Alphaproteobacteria,2KDJ8@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, cAMP Regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_2304178_28	1123267.JONN01000001_gene2393	6.408e-123	408.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K19X@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_2304178_7	392499.Swit_3968	1.41e-219	711.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PilZ
HKD2_k127_2304178_20	745310.G432_03700	2.012e-161	513.0	COG0031@1|root,COG0031@2|Bacteria,1MUBE@1224|Proteobacteria,2TS33@28211|Alphaproteobacteria,2K2A3@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the cysteine synthase cystathionine beta- synthase family	cysK	-	2.5.1.47	ko:K01738	ko00270,ko00920,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00270,map00920,map01100,map01110,map01120,map01130,map01200,map01230	M00021	R00897,R03601,R04859	RC00020,RC02814,RC02821	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_2304178_10	1030157.AFMP01000008_gene3249	5.152e-192	606.0	COG0477@1|root,COG2814@2|Bacteria,1QTX0@1224|Proteobacteria,2TUM5@28211|Alphaproteobacteria,2K1MY@204457|Sphingomonadales	204457|Sphingomonadales	EGP	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_2304178_26	1470591.BW41_02817	1.524e-137	448.0	COG0025@1|root,COG0025@2|Bacteria,1MW5T@1224|Proteobacteria,2TSHB@28211|Alphaproteobacteria,2KD59@204457|Sphingomonadales	204457|Sphingomonadales	P	Sodium/hydrogen exchanger family	-	-	-	-	-	-	-	-	-	-	-	-	Na_H_Exchanger
HKD2_k127_2304178_6	1123267.JONN01000001_gene1270	2.587e-220	696.0	COG1066@1|root,COG1066@2|Bacteria,1MUJQ@1224|Proteobacteria,2TS6F@28211|Alphaproteobacteria,2K1F3@204457|Sphingomonadales	204457|Sphingomonadales	O	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function	radA	-	-	ko:K04485	-	-	-	-	ko00000,ko03400	-	-	-	AAA_25,ATPase,ChlI
HKD2_k127_2304178_23	1545915.JROG01000003_gene1229	4.846e-145	467.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,2K121@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HKD2_k127_2304178_39	1123269.NX02_21070	3.504e-90	304.0	COG0500@1|root,COG0500@2|Bacteria,1QUSR@1224|Proteobacteria,2U78U@28211|Alphaproteobacteria,2K1PP@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_23
HKD2_k127_2304178_53	1123267.JONN01000001_gene1269	1.385e-49	181.0	COG1286@1|root,COG1286@2|Bacteria,1REF7@1224|Proteobacteria,2VA4D@28211|Alphaproteobacteria,2K52S@204457|Sphingomonadales	204457|Sphingomonadales	S	Colicin V production protein	-	-	-	ko:K03558	-	-	-	-	ko00000	-	-	-	Colicin_V
HKD2_k127_2304178_9	1123267.JONN01000001_gene1268	1.024e-198	627.0	COG0215@1|root,COG0215@2|Bacteria,1MV8H@1224|Proteobacteria,2TQQ1@28211|Alphaproteobacteria,2K19T@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	cysS	-	6.1.1.16	ko:K01883	ko00970,map00970	M00359,M00360	R03650	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_2,tRNA-synt_1e
HKD2_k127_2304178_62	1123267.JONN01000001_gene1267	5.157e-27	115.0	COG0822@1|root,COG0822@2|Bacteria,1RDGB@1224|Proteobacteria,2U74A@28211|Alphaproteobacteria,2K54B@204457|Sphingomonadales	204457|Sphingomonadales	C	NifU homolog involved in Fe-S cluster formation	-	-	-	-	-	-	-	-	-	-	-	-	NifU_N
HKD2_k127_2304178_8	745310.G432_01695	9.092e-211	673.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2K1PS@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455,ko:K11747	-	-	-	-	ko00000,ko02000	2.A.37,2.A.37.1.2	-	-	Na_H_Exchanger,TrkA_N
HKD2_k127_2304178_47	1123267.JONN01000001_gene1264	5.933e-64	224.0	COG0703@1|root,COG0703@2|Bacteria,1MUFJ@1224|Proteobacteria,2U76C@28211|Alphaproteobacteria,2K4PP@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate	aroK	-	2.7.1.71	ko:K00891	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R02412	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	SKI
HKD2_k127_2304178_80	1007104.SUS17_209	6.95e-05	46.0	2BMBY@1|root,32FW6@2|Bacteria,1Q89E@1224|Proteobacteria,2VEFA@28211|Alphaproteobacteria,2K7RR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_17	1123267.JONN01000001_gene1262	1.291e-173	563.0	2BWFC@1|root,33R2I@2|Bacteria,1R42X@1224|Proteobacteria,2U4BF@28211|Alphaproteobacteria,2K0XT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2304178_30	1123267.JONN01000001_gene1261	2.849e-120	399.0	COG4974@1|root,COG4974@2|Bacteria,1MVNF@1224|Proteobacteria,2TRAA@28211|Alphaproteobacteria,2K25K@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	xerC	-	-	ko:K04763	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_2304178_22	685778.AORL01000021_gene543	7.247e-153	488.0	COG0825@1|root,COG0825@2|Bacteria,1MURN@1224|Proteobacteria,2TR6V@28211|Alphaproteobacteria,2K0BW@204457|Sphingomonadales	204457|Sphingomonadales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA	accA	-	2.1.3.15,6.4.1.2	ko:K01962	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	ACCA
HKD2_k127_2304178_15	1123267.JONN01000002_gene189	4.276e-178	570.0	COG4784@1|root,COG4784@2|Bacteria,1QTT7@1224|Proteobacteria,2TTU7@28211|Alphaproteobacteria,2K1IX@204457|Sphingomonadales	204457|Sphingomonadales	S	peptidase M48, Ste24p	-	-	-	-	-	-	-	-	-	-	-	-	LysM,Peptidase_M48
HKD2_k127_2304178_55	1123267.JONN01000002_gene191	1.695e-45	177.0	COG0500@1|root,COG2226@2|Bacteria,1PA5F@1224|Proteobacteria,2TRFS@28211|Alphaproteobacteria,2K0V6@204457|Sphingomonadales	204457|Sphingomonadales	Q	Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_23
HKD2_k127_2304178_65	983920.Y88_0786	2.7e-24	109.0	COG0695@1|root,COG0695@2|Bacteria,1N72P@1224|Proteobacteria,2UFM1@28211|Alphaproteobacteria,2K5VT@204457|Sphingomonadales	204457|Sphingomonadales	O	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins	grxC	-	-	ko:K03676	-	-	-	-	ko00000,ko03110	-	-	-	Glutaredoxin
HKD2_k127_2304178_34	1123267.JONN01000002_gene194	3.048e-114	374.0	COG0388@1|root,COG0388@2|Bacteria,1MUUB@1224|Proteobacteria,2TRGZ@28211|Alphaproteobacteria,2K16U@204457|Sphingomonadales	204457|Sphingomonadales	S	Nitrilase cyanide hydratase and apolipoprotein N-acyltransferase	-	-	-	ko:K11206	-	-	-	-	ko00000,ko01000	-	-	-	CN_hydrolase
HKD2_k127_2304178_57	1219049.SP5_035_01500	1.828e-37	145.0	COG5319@1|root,COG5319@2|Bacteria,1MZN2@1224|Proteobacteria,2UBTA@28211|Alphaproteobacteria,2K54Q@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF1178
HKD2_k127_2304178_44	392499.Swit_1959	3.68e-74	257.0	28M8G@1|root,2ZAMM@2|Bacteria,1MVBT@1224|Proteobacteria,2TTGC@28211|Alphaproteobacteria,2K48T@204457|Sphingomonadales	204457|Sphingomonadales	S	RES	-	-	-	-	-	-	-	-	-	-	-	-	RES
HKD2_k127_2304178_60	1125973.JNLC01000014_gene2409	1.791e-29	136.0	COG1262@1|root,COG2815@1|root,COG1262@2|Bacteria,COG2815@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TIR_2
HKD2_k127_2304178_46	395964.KE386496_gene1500	1.825e-64	228.0	COG3945@1|root,COG3945@2|Bacteria,1NX3S@1224|Proteobacteria,2U1MQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Pfam Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_2304178_71	1095769.CAHF01000022_gene313	1.297e-16	81.0	COG2059@1|root,COG2059@2|Bacteria,1MUBW@1224|Proteobacteria,2VHPW@28216|Betaproteobacteria,475PT@75682|Oxalobacteraceae	28216|Betaproteobacteria	P	Chromate transporter	-	-	-	ko:K07240	-	-	-	-	ko00000,ko02000	2.A.51.1	-	-	Chromate_transp
HKD2_k127_2304178_33	323261.Noc_1225	1.984e-114	376.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,1RZ5E@1236|Gammaproteobacteria,1X098@135613|Chromatiales	135613|Chromatiales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_2304178_25	686340.Metal_3845	4.368e-138	469.0	COG2831@1|root,COG4313@1|root,COG2831@2|Bacteria,COG4313@2|Bacteria,1QW38@1224|Proteobacteria,1T2R4@1236|Gammaproteobacteria,1XEIW@135618|Methylococcales	135618|Methylococcales	U	Protein of unknown function (DUF3570)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3570
HKD2_k127_2304178_72	1116472.MGMO_41c00050	8.188e-15	78.0	2E3QA@1|root,32YN8@2|Bacteria,1N98P@1224|Proteobacteria,1SCNQ@1236|Gammaproteobacteria,1XFPB@135618|Methylococcales	135618|Methylococcales	S	Domain of unknown function (DUF4266)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4266
HKD2_k127_2304178_58	1131553.JIBI01000008_gene1309	7.859e-37	151.0	COG0526@1|root,COG0526@2|Bacteria,1MZ36@1224|Proteobacteria,2VWK8@28216|Betaproteobacteria,3741A@32003|Nitrosomonadales	28216|Betaproteobacteria	O	Redoxin domain protein	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_2304178_42	231434.JQJH01000025_gene3278	2.39e-78	269.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria,3NBRY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HKD2_k127_2304178_37	663610.JQKO01000016_gene1623	2.079e-92	312.0	COG1028@1|root,COG1028@2|Bacteria,1R7JW@1224|Proteobacteria,2U3FH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_2304178_24	663610.JQKO01000016_gene1621	2.686e-143	461.0	COG2267@1|root,COG2267@2|Bacteria,1QUW0@1224|Proteobacteria,2TWTR@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	alpha/beta hydrolase fold	-	-	3.8.1.5	ko:K01563	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05284,R05367,R05368,R05369,R05370,R07669,R07670	RC01317,RC01340,RC01341,RC02013	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_2304178_54	136993.KB900626_gene1037	9.15e-48	180.0	COG5516@1|root,COG5516@2|Bacteria,1REGN@1224|Proteobacteria,2U1EY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative stress-induced transcription regulator	-	-	-	-	-	-	-	-	-	-	-	-	ABATE,zf-CGNR
HKD2_k127_2304178_29	1112212.JH584235_gene1038	2.721e-122	398.0	COG0583@1|root,COG0583@2|Bacteria,1MUNN@1224|Proteobacteria,2VEUG@28211|Alphaproteobacteria,2K2EN@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory helix-turn-helix protein, lysR family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_2304178_40	1112212.JH584235_gene1039	9.069e-80	270.0	COG2128@1|root,COG2128@2|Bacteria,1NXI8@1224|Proteobacteria,2VF1Y@28211|Alphaproteobacteria,2KDXD@204457|Sphingomonadales	204457|Sphingomonadales	S	Carboxymuconolactone decarboxylase family	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_2355802_0	1380355.JNIJ01000051_gene2198	3.716e-214	692.0	COG1674@1|root,COG1674@2|Bacteria	2|Bacteria	D	ftsk spoiiie	-	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	AAA_11,AAA_12,FtsK_SpoIIIE,NACHT
HKD2_k127_2355802_1	272134.KB731324_gene2895	1.123e-36	160.0	COG2319@1|root,COG2319@2|Bacteria,1FZVW@1117|Cyanobacteria	1117|Cyanobacteria	A	WD domain, G-beta repeat	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C14,WD40
HKD2_k127_2580394_35	1114964.L485_19285	1.417e-49	186.0	2AK5K@1|root,31AVG@2|Bacteria,1REG7@1224|Proteobacteria,2U8E6@28211|Alphaproteobacteria,2K5AP@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	-
HKD2_k127_2580394_27	158500.BV97_04396	8.218e-73	254.0	COG0265@1|root,COG0265@2|Bacteria,1R55B@1224|Proteobacteria,2U3H7@28211|Alphaproteobacteria,2K0CF@204457|Sphingomonadales	2|Bacteria	O	Trypsin-like peptidase domain	-	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006457,GO:0006508,GO:0006515,GO:0006807,GO:0006950,GO:0006979,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009266,GO:0009408,GO:0009628,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0030288,GO:0030313,GO:0031224,GO:0031226,GO:0031233,GO:0031975,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0050896,GO:0051603,GO:0061077,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	3.4.21.107	ko:K04771,ko:K04772	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD2_k127_2580394_44	1121377.KB906400_gene1309	4.25e-12	74.0	2BHPS@1|root,32BT1@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580394_26	1211777.BN77_3262	2.191e-74	256.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U5Q0@28211|Alphaproteobacteria,4BCA3@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	SelR domain	msrB	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_2580394_17	1112216.JH594425_gene2849	6.091e-110	372.0	2E384@1|root,32Y7U@2|Bacteria,1N36R@1224|Proteobacteria,2UW56@28211|Alphaproteobacteria,2K1PQ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	ko:K18546	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	-
HKD2_k127_2580394_32	471852.Tcur_4486	3.02e-61	214.0	COG0853@1|root,COG0853@2|Bacteria,2IHTC@201174|Actinobacteria,4EJCJ@85012|Streptosporangiales	201174|Actinobacteria	H	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine	panD	-	4.1.1.11	ko:K01579	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R00489	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Asp_decarbox
HKD2_k127_2580394_42	745310.G432_15455	3.398e-14	79.0	COG1983@1|root,COG1983@2|Bacteria,1NK8Q@1224|Proteobacteria,2UNBI@28211|Alphaproteobacteria,2K844@204457|Sphingomonadales	204457|Sphingomonadales	KT	PspC domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PspC
HKD2_k127_2580394_29	1123267.JONN01000002_gene343	5.961e-67	235.0	29636@1|root,2ZTDK@2|Bacteria,1RFN7@1224|Proteobacteria,2U8TB@28211|Alphaproteobacteria,2K5I9@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580394_9	1123267.JONN01000002_gene341	1.44e-217	686.0	COG0840@1|root,COG0840@2|Bacteria,1NJXF@1224|Proteobacteria,2TTNX@28211|Alphaproteobacteria,2K1FW@204457|Sphingomonadales	204457|Sphingomonadales	NT	methyl-accepting chemotaxis protein	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HKD2_k127_2580394_8	629773.AORY01000012_gene725	4.934e-222	696.0	COG3876@1|root,COG3876@2|Bacteria,1MX3S@1224|Proteobacteria,2U1KM@28211|Alphaproteobacteria,2K0PB@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1343)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1343
HKD2_k127_2580394_28	1123267.JONN01000001_gene1071	6.507e-69	238.0	2C0PI@1|root,32VVI@2|Bacteria,1N1H7@1224|Proteobacteria,2UE1P@28211|Alphaproteobacteria,2K60G@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580394_10	1331060.RLDS_26100	5.306e-190	600.0	COG0162@1|root,COG0162@2|Bacteria,1MVUQ@1224|Proteobacteria,2TQPA@28211|Alphaproteobacteria,2K11C@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)	tyrS	-	6.1.1.1	ko:K01866	ko00970,map00970	M00359,M00360	R02918	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	S4,tRNA-synt_1b
HKD2_k127_2580394_5	1123267.JONN01000001_gene1069	3.715e-317	983.0	COG1200@1|root,COG1200@2|Bacteria,1MWN2@1224|Proteobacteria,2TR86@28211|Alphaproteobacteria,2K0MC@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent DNA helicase RecG	recG	-	3.6.4.12	ko:K03655	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C,RecG_wedge
HKD2_k127_2580394_38	1123267.JONN01000001_gene1068	1.059e-29	136.0	COG2938@1|root,COG2938@2|Bacteria,1N6SJ@1224|Proteobacteria,2VCGJ@28211|Alphaproteobacteria,2K5W5@204457|Sphingomonadales	204457|Sphingomonadales	S	Flavinator of succinate dehydrogenase	-	-	-	ko:K09159	-	-	-	-	ko00000,ko02048	-	-	-	Sdh5
HKD2_k127_2580394_0	1123267.JONN01000001_gene1067	0.0	1796.0	COG1197@1|root,COG1197@2|Bacteria,1MUXG@1224|Proteobacteria,2TR2H@28211|Alphaproteobacteria,2K07V@204457|Sphingomonadales	204457|Sphingomonadales	L	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site	mfd	-	-	ko:K03723	ko03420,map03420	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	CarD_CdnL_TRCF,DEAD,Helicase_C,TRCF
HKD2_k127_2580394_23	1112216.JH594425_gene1926	1.895e-83	284.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U7R8@28211|Alphaproteobacteria,2KDKG@204457|Sphingomonadales	28211|Alphaproteobacteria	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580394_21	1123267.JONN01000001_gene1065	8.623e-91	306.0	COG5001@1|root,COG5001@2|Bacteria,1QWUF@1224|Proteobacteria,2TX5E@28211|Alphaproteobacteria,2KEGM@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_2580394_18	1123267.JONN01000001_gene1064	1.661e-105	348.0	COG0061@1|root,COG0061@2|Bacteria,1MUBC@1224|Proteobacteria,2TSKN@28211|Alphaproteobacteria,2K0E6@204457|Sphingomonadales	204457|Sphingomonadales	G	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP	ppnK	-	2.7.1.23	ko:K00858	ko00760,ko01100,map00760,map01100	-	R00104	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	NAD_kinase
HKD2_k127_2580394_37	1121022.ABENE_19445	1.21e-45	171.0	COG0454@1|root,COG0454@2|Bacteria,1NHSU@1224|Proteobacteria	1224|Proteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_10,Acetyltransf_7
HKD2_k127_2580394_31	1283300.ATXB01000001_gene1373	4.825e-63	228.0	COG4424@1|root,COG4424@2|Bacteria,1RGI6@1224|Proteobacteria,1S85X@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1,Sulfotransfer_3
HKD2_k127_2580394_15	1449049.JONW01000008_gene489	1.597e-131	436.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,2KH9Q@204458|Caulobacterales	204458|Caulobacterales	M	TIGRFAM type I secretion membrane fusion protein, HlyD family	-	-	-	ko:K02022	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD,HlyD_3
HKD2_k127_2580394_12	1449049.JONW01000008_gene490	1.222e-168	547.0	COG4618@1|root,COG4618@2|Bacteria,1NTI5@1224|Proteobacteria,2TR17@28211|Alphaproteobacteria	28211|Alphaproteobacteria	V	COG4618 ABC-type protease lipase transport system, ATPase and permease components	-	-	-	ko:K06148,ko:K12536,ko:K16299	ko02010,map02010	M00328,M00571	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1,3.A.1.110,3.A.1.110.10	-	-	ABC_membrane,ABC_tran
HKD2_k127_2580394_2	1123267.JONN01000001_gene1061	0.0	1444.0	COG0506@1|root,COG4230@1|root,COG0506@2|Bacteria,COG4230@2|Bacteria,1MV93@1224|Proteobacteria,2TQPT@28211|Alphaproteobacteria,2K1B6@204457|Sphingomonadales	204457|Sphingomonadales	CE	Oxidizes proline to glutamate for use as a carbon and nitrogen source	putA	-	1.2.1.88,1.5.5.2	ko:K13821	ko00250,ko00330,ko01100,ko01110,ko01130,map00250,map00330,map01100,map01110,map01130	-	R00245,R00707,R00708,R01253,R04444,R04445,R05051	RC00080,RC00083,RC00216,RC00242,RC00255	ko00000,ko00001,ko01000,ko03000	-	-	-	Aldedh,Pro_dh,Pro_dh-DNA_bdg
HKD2_k127_2580394_1	1123267.JONN01000001_gene1060	0.0	1449.0	COG0653@1|root,COG0653@2|Bacteria,1MUJZ@1224|Proteobacteria,2TTBF@28211|Alphaproteobacteria,2K1MX@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane	secA	-	-	ko:K03070	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.10,3.A.5.2,3.A.5.4	-	-	SEC-C,SecA_DEAD,SecA_PP_bind,SecA_SW
HKD2_k127_2580394_30	1449076.JOOE01000001_gene2354	6.625e-64	223.0	COG3791@1|root,COG3791@2|Bacteria,1N6S5@1224|Proteobacteria,2UG0P@28211|Alphaproteobacteria,2KD97@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_2580394_36	1123267.JONN01000001_gene1059	6.788e-49	188.0	COG3118@1|root,COG3118@2|Bacteria,1MZBB@1224|Proteobacteria,2UCCR@28211|Alphaproteobacteria,2K589@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the thioredoxin family	trxA	-	-	ko:K03671	ko04621,ko05418,map04621,map05418	-	-	-	ko00000,ko00001,ko03110	-	-	-	Thioredoxin
HKD2_k127_2580394_3	1123267.JONN01000001_gene1058	0.0	1071.0	COG1074@1|root,COG1074@2|Bacteria,1MUTF@1224|Proteobacteria,2TQJZ@28211|Alphaproteobacteria,2K07I@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the helicase family. UvrD subfamily	addA	-	3.6.4.12	ko:K16898	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1,UvrD-helicase,UvrD_C
HKD2_k127_2580394_4	392499.Swit_2680	0.0	1022.0	COG2887@1|root,COG3893@1|root,COG2887@2|Bacteria,COG3893@2|Bacteria,1MY2G@1224|Proteobacteria,2TS74@28211|Alphaproteobacteria,2K06P@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	addB	-	3.6.4.12	ko:K16899	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	PDDEXK_1
HKD2_k127_2580394_16	1123267.JONN01000001_gene1055	1.349e-115	385.0	COG1208@1|root,COG1208@2|Bacteria,1R9ZD@1224|Proteobacteria,2TU2V@28211|Alphaproteobacteria,2K1HH@204457|Sphingomonadales	204457|Sphingomonadales	JM	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits (eIF-2Bgamma eIF-2Bepsilon)	-	-	2.7.7.99	ko:K00992	ko00520,ko01100,map00520,map01100	-	R11025	RC00002	ko00000,ko00001,ko01000	-	-	-	NTP_transf_3,NTP_transferase
HKD2_k127_2580394_13	1123267.JONN01000001_gene1054	1.251e-155	498.0	COG3178@1|root,COG3178@2|Bacteria,1MXCH@1224|Proteobacteria,2TSJD@28211|Alphaproteobacteria,2K04R@204457|Sphingomonadales	204457|Sphingomonadales	S	Phosphotransferase	-	-	2.7.1.221	ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000	-	-	-	APH
HKD2_k127_2580394_40	1280948.HY36_15785	5.235e-26	112.0	COG0802@1|root,COG0802@2|Bacteria,1RGYU@1224|Proteobacteria,2UBQ9@28211|Alphaproteobacteria,43Y3K@69657|Hyphomonadaceae	28211|Alphaproteobacteria	S	ATPase or kinase	-	-	2.7.1.221	ko:K06925,ko:K07102	ko00520,ko01100,map00520,map01100	-	R08968,R11024	RC00002,RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	TsaE
HKD2_k127_2580394_6	1123267.JONN01000001_gene1052	2.924e-282	887.0	COG0642@1|root,COG2205@2|Bacteria,1MVY8@1224|Proteobacteria,2TS5B@28211|Alphaproteobacteria,2K08R@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_7
HKD2_k127_2580394_7	1346791.M529_10090	9.073e-273	842.0	COG0499@1|root,COG0499@2|Bacteria,1MUQ2@1224|Proteobacteria,2TSJY@28211|Alphaproteobacteria,2K0R8@204457|Sphingomonadales	204457|Sphingomonadales	H	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine	ahcY	-	3.3.1.1	ko:K01251	ko00270,ko01100,map00270,map01100	M00035	R00192,R04936	RC00056,RC00069,RC01161,RC01243	ko00000,ko00001,ko00002,ko01000,ko01009,ko04147	-	-	-	AdoHcyase,AdoHcyase_NAD
HKD2_k127_2580394_22	1114964.L485_09115	8.038e-90	309.0	COG0392@1|root,COG0392@2|Bacteria,1R468@1224|Proteobacteria,2U0QT@28211|Alphaproteobacteria,2K65B@204457|Sphingomonadales	204457|Sphingomonadales	S	Lysylphosphatidylglycerol synthase TM region	-	-	-	-	-	-	-	-	-	-	-	-	LPG_synthase_TM
HKD2_k127_2580394_19	1123267.JONN01000001_gene1047	4.125e-99	326.0	COG1678@1|root,COG1678@2|Bacteria,1RCXM@1224|Proteobacteria,2TTX4@28211|Alphaproteobacteria,2K3S2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the UPF0301 (AlgH) family	-	-	-	ko:K07735	-	-	-	-	ko00000,ko03000	-	-	-	DUF179
HKD2_k127_2580394_25	1123267.JONN01000001_gene1046	1.879e-78	264.0	COG0678@1|root,COG0678@2|Bacteria,1MU0H@1224|Proteobacteria,2U6ZN@28211|Alphaproteobacteria,2K3WE@204457|Sphingomonadales	204457|Sphingomonadales	O	Alkyl hydroperoxide reductase	-	-	-	-	-	-	-	-	-	-	-	-	Redoxin
HKD2_k127_2580394_20	1174684.EBMC1_05774	5.019e-91	310.0	COG2267@1|root,COG2267@2|Bacteria,1QUNU@1224|Proteobacteria,2TW29@28211|Alphaproteobacteria,2K09G@204457|Sphingomonadales	204457|Sphingomonadales	I	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_2580394_33	1123267.JONN01000002_gene254	1.908e-58	207.0	COG3791@1|root,COG3791@2|Bacteria,1RE8S@1224|Proteobacteria,2U73V@28211|Alphaproteobacteria,2K4NT@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_2580394_34	745310.G432_04905	1.545e-52	200.0	2DWG9@1|root,34073@2|Bacteria,1NVA6@1224|Proteobacteria,2URJH@28211|Alphaproteobacteria,2K8JR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2580394_24	1502850.FG91_03539	5.569e-82	277.0	COG3128@1|root,COG3128@2|Bacteria,1MUI7@1224|Proteobacteria,2TRH2@28211|Alphaproteobacteria,2K99V@204457|Sphingomonadales	204457|Sphingomonadales	C	Prolyl 4-hydroxylase alpha subunit homologues.	-	-	-	ko:K07336	-	-	-	-	ko00000,ko01000	-	-	-	2OG-FeII_Oxy_3
HKD2_k127_2580394_11	1123269.NX02_12995	1.228e-179	570.0	COG0136@1|root,COG0136@2|Bacteria,1MUHG@1224|Proteobacteria,2TSRD@28211|Alphaproteobacteria,2K104@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate	asd	-	1.2.1.11	ko:K00133	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R02291	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh,Semialdhyde_dhC
HKD2_k127_2580394_14	1123267.JONN01000002_gene251	1.116e-131	448.0	COG2234@1|root,COG2234@2|Bacteria,1R56X@1224|Proteobacteria,2U2G7@28211|Alphaproteobacteria,2K2WC@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD2_k127_2580394_48	1449076.JOOE01000003_gene3197	1.32e-05	49.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,2K414@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HKD2_k127_2584012_1	1385517.N800_01230	8.149e-99	334.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1X5F4@135614|Xanthomonadales	135614|Xanthomonadales	E	homoserine dehydrogenase	metL	-	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
HKD2_k127_2584012_0	84531.JMTZ01000101_gene1453	6.689e-172	547.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,1RMCV@1236|Gammaproteobacteria,1X4AH@135614|Xanthomonadales	135614|Xanthomonadales	E	cystathionine	metB	-	2.5.1.48	ko:K01739	ko00270,ko00450,ko00920,ko01100,ko01110,ko01130,ko01230,map00270,map00450,map00920,map01100,map01110,map01130,map01230	M00017	R00999,R01288,R02508,R03217,R03260,R04944,R04945,R04946	RC00020,RC00056,RC00069,RC00420,RC02848,RC02866	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_2584012_2	1552758.NC00_18480	2.065e-44	167.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,1RXCB@1236|Gammaproteobacteria,1X4WJ@135614|Xanthomonadales	135614|Xanthomonadales	E	Belongs to the AB hydrolase superfamily. MetX family	metXS	GO:0000096,GO:0000097,GO:0003674,GO:0003824,GO:0004414,GO:0006082,GO:0006520,GO:0006555,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0008374,GO:0008652,GO:0009058,GO:0009066,GO:0009067,GO:0009069,GO:0009086,GO:0009092,GO:0009987,GO:0016053,GO:0016407,GO:0016413,GO:0016740,GO:0016746,GO:0016747,GO:0019752,GO:0043436,GO:0044237,GO:0044238,GO:0044249,GO:0044272,GO:0044281,GO:0044283,GO:0046394,GO:0071704,GO:1901564,GO:1901566,GO:1901576,GO:1901605,GO:1901607	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_2638603_5	420324.KI912025_gene67	3.771e-08	58.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,1JSCQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_2638603_3	375286.mma_2413	1.035e-28	123.0	COG2149@1|root,COG2149@2|Bacteria,1N8RW@1224|Proteobacteria,2VYKE@28216|Betaproteobacteria	28216|Betaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD2_k127_2638603_0	627192.SLG_25200	7.258e-293	921.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,2K0ZP@204457|Sphingomonadales	204457|Sphingomonadales	P	Cation transporter/ATPase, N-terminus	-	-	3.6.3.2,3.6.3.6	ko:K01531,ko:K01535	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.3.3,3.A.3.4	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase
HKD2_k127_2638603_4	1187851.A33M_3863	6.027e-27	116.0	COG2010@1|root,COG2010@2|Bacteria	2|Bacteria	C	Cytochrome c	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrome_CBB3
HKD2_k127_2638603_1	317655.Sala_0594	8.487e-112	371.0	COG0426@1|root,COG0426@2|Bacteria,1MXIE@1224|Proteobacteria,2U3GM@28211|Alphaproteobacteria,2KA6Y@204457|Sphingomonadales	204457|Sphingomonadales	C	domain, Protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2638603_2	1123267.JONN01000001_gene1968	6.28e-69	235.0	COG1696@1|root,COG1696@2|Bacteria,1MUXN@1224|Proteobacteria,2TRD1@28211|Alphaproteobacteria,2K0G7@204457|Sphingomonadales	204457|Sphingomonadales	M	Membrane bound O-acyl transferase, MBOAT family protein	-	-	-	-	-	-	-	-	-	-	-	-	MBOAT
HKD2_k127_2659229_4	1041146.ATZB01000035_gene633	1.659e-45	169.0	COG1396@1|root,COG1396@2|Bacteria,1N3BI@1224|Proteobacteria,2UC1D@28211|Alphaproteobacteria,4BEH1@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	TIGRFAM mobile mystery protein A	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3
HKD2_k127_2659229_2	1057002.KB905370_gene2589	2.485e-68	237.0	COG2184@1|root,COG2184@2|Bacteria,1RAVF@1224|Proteobacteria,2U59F@28211|Alphaproteobacteria,4BB92@82115|Rhizobiaceae	28211|Alphaproteobacteria	D	Fic/DOC family	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_2659229_5	1122614.JHZF01000013_gene3266	1.025e-06	55.0	COG2350@1|root,COG2350@2|Bacteria,1MZ9Z@1224|Proteobacteria,2UF4X@28211|Alphaproteobacteria,2PEKE@252301|Oceanicola	28211|Alphaproteobacteria	S	YCII-related domain	yciI	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0044424,GO:0044444,GO:0044464	-	ko:K09780	-	-	-	-	ko00000	-	-	-	YCII
HKD2_k127_2659229_3	1123267.JONN01000001_gene1039	1.755e-47	174.0	COG1846@1|root,COG1846@2|Bacteria,1MZY5@1224|Proteobacteria,2U9EE@28211|Alphaproteobacteria,2K62J@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_2659229_1	1123267.JONN01000001_gene1040	4.322e-117	387.0	COG1566@1|root,COG1566@2|Bacteria,1MU7I@1224|Proteobacteria,2TS39@28211|Alphaproteobacteria,2K1WC@204457|Sphingomonadales	204457|Sphingomonadales	V	Secretion protein, HlyD	-	-	-	ko:K03543	-	M00701	-	-	ko00000,ko00002,ko02000	8.A.1.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_2659229_0	1123267.JONN01000001_gene1041	7.467e-222	698.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JZYF@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_2694854_2	1123269.NX02_01560	1.654e-51	183.0	COG0250@1|root,COG0250@2|Bacteria,1MU14@1224|Proteobacteria,2TRID@28211|Alphaproteobacteria,2K0IB@204457|Sphingomonadales	204457|Sphingomonadales	K	Participates in transcription elongation, termination and antitermination	nusG	-	-	ko:K02601	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	KOW,NusG
HKD2_k127_2694854_4	1550073.JROH01000036_gene2661	1.896e-22	98.0	2FC5G@1|root,3449A@2|Bacteria,1NB1K@1224|Proteobacteria,2UFY7@28211|Alphaproteobacteria,2K6YG@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2694854_3	395964.KE386496_gene1973	1.839e-29	122.0	COG1917@1|root,COG1917@2|Bacteria,1MZF9@1224|Proteobacteria,2U63E@28211|Alphaproteobacteria,3NBNU@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,Cupin_7,DUF4437
HKD2_k127_2694854_1	1123267.JONN01000001_gene1612	6.055e-71	241.0	COG0080@1|root,COG0080@2|Bacteria,1RA2M@1224|Proteobacteria,2U760@28211|Alphaproteobacteria,2K3Z9@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors	rplK	-	-	ko:K02867	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L11,Ribosomal_L11_N
HKD2_k127_2694854_0	1090319.KE386571_gene2203	2.001e-111	363.0	COG0081@1|root,COG0081@2|Bacteria,1MUE6@1224|Proteobacteria,2TRXP@28211|Alphaproteobacteria,2K0YM@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release	rplA	-	-	ko:K02863	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L1
HKD2_k127_2694854_5	1219035.NT2_07_00600	0.0007204	44.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria,2K90M@204457|Sphingomonadales	204457|Sphingomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_2774605_33	1192759.AKIB01000112_gene3415	4.625e-40	153.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,2K3F8@204457|Sphingomonadales	204457|Sphingomonadales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_2774605_36	1248917.ANFX01000012_gene1767	8.987e-36	143.0	COG4944@1|root,COG4944@2|Bacteria,1N3C7@1224|Proteobacteria,2VGWG@28211|Alphaproteobacteria,2K5Z0@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD2_k127_2774605_21	1120705.FG95_03056	2.059e-58	210.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,2U0XJ@28211|Alphaproteobacteria,2K4DJ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_2774605_37	1125973.JNLC01000014_gene2409	1.979e-32	145.0	COG1262@1|root,COG2815@1|root,COG1262@2|Bacteria,COG2815@2|Bacteria,1NQ5K@1224|Proteobacteria,2U2VJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase,TIR_2
HKD2_k127_2774605_43	1123073.KB899243_gene682	2.283e-05	57.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,1S1MS@1236|Gammaproteobacteria,1X9IC@135614|Xanthomonadales	135614|Xanthomonadales	S	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_18	392499.Swit_3716	5.864e-78	267.0	COG3658@1|root,COG3658@2|Bacteria,1RB03@1224|Proteobacteria,2VGBI@28211|Alphaproteobacteria,2KE2X@204457|Sphingomonadales	204457|Sphingomonadales	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_2774605_17	13689.BV96_03441	2.754e-86	291.0	COG1814@1|root,COG1814@2|Bacteria,1MUZE@1224|Proteobacteria,2TT6M@28211|Alphaproteobacteria,2K1CI@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_2774605_0	1123267.JONN01000001_gene1294	0.0	1695.0	COG0178@1|root,COG0178@2|Bacteria,1MW0W@1224|Proteobacteria,2TQK9@28211|Alphaproteobacteria,2K0VM@204457|Sphingomonadales	204457|Sphingomonadales	L	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate	uvrA	-	-	ko:K03701	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	ABC_tran
HKD2_k127_2774605_20	629773.AORY01000012_gene1054	9.201e-59	213.0	2E6R2@1|root,331B7@2|Bacteria,1MZ2F@1224|Proteobacteria,2UB90@28211|Alphaproteobacteria,2K4RC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_32	745310.G432_13305	1.887e-41	156.0	COG3791@1|root,COG3791@2|Bacteria,1N7AZ@1224|Proteobacteria,2UFKY@28211|Alphaproteobacteria,2K6EG@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_34	1282360.ABAC460_00880	8.399e-38	143.0	COG3254@1|root,COG3254@2|Bacteria,1RIRS@1224|Proteobacteria,2UAT0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	rhamnose metabolic process	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_2774605_4	1123267.JONN01000001_gene610	2.296e-293	912.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2K27B@204457|Sphingomonadales	204457|Sphingomonadales	I	acetyl propionyl-CoA carboxylase, alpha subunit	-	-	6.4.1.4	ko:K01968	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_2774605_31	1081640.AGFU01000021_gene1962	7.736e-43	166.0	2CM2H@1|root,32SDI@2|Bacteria,1NPEY@1224|Proteobacteria,2UJZ9@28211|Alphaproteobacteria,2K430@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Lumazine_bd_2
HKD2_k127_2774605_10	1123267.JONN01000001_gene608	2.817e-174	551.0	COG0502@1|root,COG0502@2|Bacteria,1MVFF@1224|Proteobacteria,2TSD6@28211|Alphaproteobacteria,2K19B@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism	bioB	-	2.8.1.6	ko:K01012	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R01078	RC00441	ko00000,ko00001,ko00002,ko01000	-	-	-	BATS,Radical_SAM
HKD2_k127_2774605_3	1248760.ANFZ01000006_gene2266	9.426e-307	946.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRA0@28211|Alphaproteobacteria,2K0B0@204457|Sphingomonadales	204457|Sphingomonadales	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	-	-	6.4.1.4	ko:K01969	ko00280,ko01100,map00280,map01100	M00036	R04138	RC00367,RC00942	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_2774605_7	1242864.D187_000733	3.989e-217	688.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria	1224|Proteobacteria	U	Peptidase m28	-	-	-	ko:K01269	-	-	-	-	ko00000,ko01000	-	-	-	PA,Peptidase_M28
HKD2_k127_2774605_27	1163408.UU9_07074	2.805e-52	194.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,1S2WK@1236|Gammaproteobacteria,1X5N0@135614|Xanthomonadales	135614|Xanthomonadales	M	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	PCMT
HKD2_k127_2774605_29	1282360.ABAC460_22025	1.145e-45	175.0	COG2010@1|root,COG2010@2|Bacteria,1NEUK@1224|Proteobacteria,2UIJ4@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C,Cytochrome_CBB3
HKD2_k127_2774605_8	1123267.JONN01000001_gene604	2.555e-213	668.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TREJ@28211|Alphaproteobacteria,2K1PX@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the formation of 3-methylbut-2-enoyl CoA from 3-methylbutanoyl CoA	-	-	1.3.8.4	ko:K00253	ko00280,ko01100,map00280,map01100	M00036	R04095	RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_2774605_9	1479239.JQMU01000001_gene2823	3.183e-179	573.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K0FQ@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation	-	-	2.3.1.9	ko:K00626	ko00071,ko00072,ko00280,ko00310,ko00362,ko00380,ko00620,ko00630,ko00640,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00310,map00362,map00380,map00620,map00630,map00640,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00088,M00095,M00373,M00374,M00375	R00238,R01177	RC00004,RC00326	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_2774605_35	1192868.CAIU01000008_gene873	1.06e-37	146.0	COG0251@1|root,COG0251@2|Bacteria,1MZ3J@1224|Proteobacteria,2UGES@28211|Alphaproteobacteria,43P5X@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	J	Endoribonuclease L-PSP	-	-	-	-	-	-	-	-	-	-	-	-	Ribonuc_L-PSP
HKD2_k127_2774605_24	1123267.JONN01000001_gene600	3.916e-56	203.0	COG3807@1|root,COG3807@2|Bacteria,1RHM2@1224|Proteobacteria,2UA1R@28211|Alphaproteobacteria,2K42W@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SH3_4
HKD2_k127_2774605_5	1123267.JONN01000001_gene599	2.538e-281	868.0	COG2070@1|root,COG2070@2|Bacteria,1N52W@1224|Proteobacteria,2TV8B@28211|Alphaproteobacteria,2K00A@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	-	-	-	-	-	-	-	-	-	-	NMO
HKD2_k127_2774605_44	7217.FBpp0115724	5.27e-05	53.0	2FJFK@1|root,2TKWZ@2759|Eukaryota,39I2N@33154|Opisthokonta,3CMVZ@33208|Metazoa,3E3I2@33213|Bilateria,42878@6656|Arthropoda,3SXTJ@50557|Insecta,454JD@7147|Diptera,45U7D@7214|Drosophilidae	33208|Metazoa	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_12	1123267.JONN01000001_gene597	7.304e-132	425.0	COG0157@1|root,COG0157@2|Bacteria,1MW0C@1224|Proteobacteria,2TS7C@28211|Alphaproteobacteria,2K19F@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the NadC ModD family	-	-	-	-	-	-	-	-	-	-	-	-	QRPTase_C,QRPTase_N
HKD2_k127_2774605_14	1123267.JONN01000001_gene596	1.405e-98	330.0	COG1409@1|root,COG1409@2|Bacteria,1MW6B@1224|Proteobacteria,2U1GX@28211|Alphaproteobacteria,2K28P@204457|Sphingomonadales	204457|Sphingomonadales	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_2774605_26	1123267.JONN01000001_gene593	3.937e-53	194.0	COG0494@1|root,COG0494@2|Bacteria,1RE72@1224|Proteobacteria,2U805@28211|Alphaproteobacteria,2K4H0@204457|Sphingomonadales	204457|Sphingomonadales	L	Nudix hydrolase	-	-	3.6.1.13	ko:K01515	ko00230,map00230	-	R01054	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX
HKD2_k127_2774605_23	1346791.M529_07510	1.886e-56	210.0	COG3762@1|root,COG3762@2|Bacteria,1R61N@1224|Proteobacteria,2U5XG@28211|Alphaproteobacteria,2K470@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	ko:K08988	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD2_k127_2774605_19	392499.Swit_3453	9.308e-70	246.0	COG1512@1|root,COG1512@2|Bacteria,1PB41@1224|Proteobacteria,2TUVD@28211|Alphaproteobacteria,2K1AR@204457|Sphingomonadales	204457|Sphingomonadales	S	Methanol dehydrogenase	-	-	-	ko:K06872	-	-	-	-	ko00000	-	-	-	TPM_phosphatase
HKD2_k127_2774605_16	1123267.JONN01000001_gene589	7.995e-89	297.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2TRJR@28211|Alphaproteobacteria,2K3WZ@204457|Sphingomonadales	204457|Sphingomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_2774605_22	685778.AORL01000022_gene1306	4.101e-58	205.0	COG1970@1|root,COG1970@2|Bacteria,1RHG8@1224|Proteobacteria,2U99Y@28211|Alphaproteobacteria,2K54X@204457|Sphingomonadales	204457|Sphingomonadales	M	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell	mscL	-	-	ko:K03282	-	-	-	-	ko00000,ko02000	1.A.22.1	-	-	MscL
HKD2_k127_2774605_2	685778.AORL01000013_gene1965	0.0	1129.0	COG1228@1|root,COG1228@2|Bacteria,1R7TW@1224|Proteobacteria,2VFMX@28211|Alphaproteobacteria,2KDXF@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_2774605_28	1123269.NX02_22300	7.48e-46	175.0	2D5TK@1|root,32TJS@2|Bacteria,1RGDJ@1224|Proteobacteria,2U915@28211|Alphaproteobacteria,2K4I8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_25	1123267.JONN01000001_gene586	1.504e-55	205.0	COG1051@1|root,COG1051@2|Bacteria,1QUPQ@1224|Proteobacteria,2TW3M@28211|Alphaproteobacteria,2K0RT@204457|Sphingomonadales	204457|Sphingomonadales	F	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_2774605_38	1123267.JONN01000001_gene584	1.596e-29	123.0	COG5531@1|root,COG5531@2|Bacteria,1N3MD@1224|Proteobacteria,2UC9T@28211|Alphaproteobacteria,2KCA8@204457|Sphingomonadales	204457|Sphingomonadales	B	SWI complex, BAF60b domains	-	-	-	-	-	-	-	-	-	-	-	-	SWIB
HKD2_k127_2774605_15	1123267.JONN01000001_gene583	2.122e-91	311.0	COG1619@1|root,COG1619@2|Bacteria,1MWIY@1224|Proteobacteria,2U0U5@28211|Alphaproteobacteria,2K08M@204457|Sphingomonadales	204457|Sphingomonadales	V	proteins, homologs of microcin C7 resistance protein MccF	-	-	3.4.17.13	ko:K01297	-	-	-	-	ko00000,ko01000,ko01002,ko01011	-	-	-	Peptidase_S66
HKD2_k127_2774605_42	1121272.KB903291_gene3427	3.465e-06	57.0	COG2885@1|root,COG2885@2|Bacteria,2HUAY@201174|Actinobacteria,4DDSS@85008|Micromonosporales	201174|Actinobacteria	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	BON,OmpA
HKD2_k127_2774605_30	43989.cce_3457	1.219e-43	169.0	29WFE@1|root,30I19@2|Bacteria,1GQ76@1117|Cyanobacteria,3KIWC@43988|Cyanothece	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_6	745310.G432_10805	1.64e-248	779.0	COG3653@1|root,COG3653@2|Bacteria,1MWWY@1224|Proteobacteria,2TSZZ@28211|Alphaproteobacteria,2K1RR@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	3.5.1.81	ko:K06015	-	-	R02192	RC00064,RC00328	ko00000,ko01000	-	-	-	Amidohydro_3
HKD2_k127_2774605_13	1287276.X752_26760	6.568e-130	420.0	28QIE@1|root,2ZD0E@2|Bacteria,1NR13@1224|Proteobacteria,2UQ53@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_2774605_1	717785.HYPMC_1740	0.0	1401.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2TTXG@28211|Alphaproteobacteria,3N9EM@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_2774605_11	1037409.BJ6T_52880	2.39e-155	496.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2TRJH@28211|Alphaproteobacteria,3JTEW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD2_k127_2774605_40	1123267.JONN01000001_gene582	3.17e-23	110.0	COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2K0S4@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-N-acetylmuramate-alanine ligase	-	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_2912857_2	717785.HYPMC_4099	2.288e-75	259.0	COG0845@1|root,COG0845@2|Bacteria,1MW65@1224|Proteobacteria,2TSB6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	MA20_27120	-	-	ko:K07799,ko:K18990	ko02020,map02020	M00648,M00720	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2.30,8.A.1	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_2912857_0	717785.HYPMC_4098	0.0	1554.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3N6DF@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	MA20_27115	-	-	ko:K03296,ko:K07788,ko:K07789	ko02020,map02020	M00648	-	-	ko00000,ko00001,ko00002,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_2912857_1	582899.Hden_3409	6.009e-196	619.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,3N67K@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD2_k127_2947566_1	1123267.JONN01000001_gene1006	1.02e-62	218.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,2K18A@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_2947566_2	1123267.JONN01000001_gene1005	9.281e-57	204.0	2923J@1|root,2ZPNK@2|Bacteria,1NHX1@1224|Proteobacteria,2UC0M@28211|Alphaproteobacteria,2K5BN@204457|Sphingomonadales	204457|Sphingomonadales	S	rod shape-determining protein MreD	-	-	-	ko:K03571	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreD
HKD2_k127_2947566_0	1123267.JONN01000001_gene1004	4.171e-178	569.0	COG0768@1|root,COG0768@2|Bacteria,1MV8C@1224|Proteobacteria,2TRXN@28211|Alphaproteobacteria,2JZYI@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	mrdA	-	3.4.16.4	ko:K05515	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_298557_0	865937.Gilli_3289	4.429e-47	177.0	COG3439@1|root,COG3439@2|Bacteria,4NQRI@976|Bacteroidetes,1I2XY@117743|Flavobacteriia,2P6Z2@244698|Gillisia	976|Bacteroidetes	S	Domain of unknown function DUF302	-	-	-	-	-	-	-	-	-	-	-	-	DUF302
HKD2_k127_298557_1	211114.JOEF01000015_gene3470	2.964e-37	143.0	2EY5M@1|root,33REA@2|Bacteria,2I8SA@201174|Actinobacteria,4E8C8@85010|Pseudonocardiales	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_309643_8	395963.Bind_0461	1.074e-61	220.0	COG1011@1|root,COG1011@2|Bacteria,1MVWN@1224|Proteobacteria,2TS5K@28211|Alphaproteobacteria,3NBRY@45404|Beijerinckiaceae	28211|Alphaproteobacteria	S	Haloacid dehalogenase-like hydrolase	-	-	3.8.1.2	ko:K01560	ko00361,ko00625,ko01100,ko01120,map00361,map00625,map01100,map01120	-	R05287	RC00697	ko00000,ko00001,ko01000	-	-	-	HAD_2,Hydrolase
HKD2_k127_309643_15	935548.KI912159_gene1531	2.127e-30	127.0	COG3153@1|root,COG3153@2|Bacteria,1QY69@1224|Proteobacteria,2VGFQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_309643_13	395961.Cyan7425_0192	2.587e-41	156.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	-	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase,Phos_pyr_kin
HKD2_k127_309643_16	46429.BV95_04232	2.118e-17	87.0	COG3794@1|root,COG3794@2|Bacteria,1N2CZ@1224|Proteobacteria,2UEDD@28211|Alphaproteobacteria,2K66I@204457|Sphingomonadales	204457|Sphingomonadales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_309643_7	1112214.AHIS01000050_gene2413	6.595e-75	259.0	COG0785@1|root,COG0785@2|Bacteria,1MVV0@1224|Proteobacteria,2TUNG@28211|Alphaproteobacteria,2K5TQ@204457|Sphingomonadales	204457|Sphingomonadales	O	Cytochrome C biogenesis protein transmembrane region	-	-	-	-	-	-	-	-	-	-	-	-	DsbD
HKD2_k127_309643_14	1112214.AHIS01000050_gene2412	5.15e-32	130.0	COG0526@1|root,COG0526@2|Bacteria,1PVQ1@1224|Proteobacteria,2VC1J@28211|Alphaproteobacteria,2KAU7@204457|Sphingomonadales	204457|Sphingomonadales	CO	Thioredoxin-like	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_309643_11	1123267.JONN01000001_gene800	4.429e-49	184.0	COG1755@1|root,COG1755@2|Bacteria,1RERZ@1224|Proteobacteria,2U77M@28211|Alphaproteobacteria,2K4HJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Phospholipid methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	ICMT
HKD2_k127_309643_5	1123267.JONN01000001_gene801	2.384e-124	407.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,2K1FI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
HKD2_k127_309643_17	1120705.FG95_00447	1.32e-09	66.0	COG3682@1|root,COG3682@2|Bacteria,1N95N@1224|Proteobacteria,2UISP@28211|Alphaproteobacteria,2K5C7@204457|Sphingomonadales	204457|Sphingomonadales	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD2_k127_309643_1	1219035.NT2_05_00020	4.83e-259	819.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K04M@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_2,TPR_8
HKD2_k127_309643_3	194867.ALBQ01000009_gene2338	1.217e-155	514.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K26Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_8
HKD2_k127_309643_0	1123267.JONN01000001_gene1985	0.0	1261.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_309643_4	745310.G432_07985	7.844e-129	421.0	COG0156@1|root,COG0156@2|Bacteria,1MVVH@1224|Proteobacteria,2TTAK@28211|Alphaproteobacteria,2JZVV@204457|Sphingomonadales	204457|Sphingomonadales	E	8-amino-7-oxononanoate synthase	bioF	-	2.3.1.47	ko:K00652	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03210,R10124	RC00004,RC00039,RC02725	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_309643_6	1081640.AGFU01000014_gene2074	4.095e-80	273.0	COG0132@1|root,COG0132@2|Bacteria,1RDRK@1224|Proteobacteria,2U5AJ@28211|Alphaproteobacteria,2K151@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring	bioD	-	2.1.1.197,6.3.3.3	ko:K01935,ko:K02169	ko00780,ko01100,map00780,map01100	M00123,M00572,M00573,M00577	R03182,R09543	RC00003,RC00460,RC00868	ko00000,ko00001,ko00002,ko01000	-	-	-	AAA_26
HKD2_k127_309643_2	1549858.MC45_07855	4.631e-186	591.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,2K04K@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	bioA	-	2.6.1.62	ko:K00833	ko00780,ko01100,map00780,map01100	M00123,M00573,M00577	R03231	RC00006,RC00887	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_309643_12	629773.AORY01000004_gene278	2.011e-48	176.0	COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,2K5AH@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_309643_10	1192759.AKIB01000006_gene34	3.25e-53	198.0	COG4944@1|root,COG4944@2|Bacteria,1MXEV@1224|Proteobacteria,2TQKY@28211|Alphaproteobacteria,2K1EV@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1109)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1109
HKD2_k127_309643_9	1192759.AKIB01000006_gene33	7.081e-55	202.0	COG1595@1|root,COG1595@2|Bacteria,1MVS7@1224|Proteobacteria,2U0XJ@28211|Alphaproteobacteria,2K4DJ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_309643_18	59538.XP_005974117.1	1.672e-08	60.0	COG0625@1|root,KOG0867@2759|Eukaryota	2759|Eukaryota	O	Belongs to the GST superfamily	-	-	-	-	-	-	-	-	-	-	-	-	GST_C,GST_N_3
HKD2_k127_3150445_14	1532558.JL39_23460	1.066e-117	384.0	COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,2U1TN@28211|Alphaproteobacteria,4BBJQ@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
HKD2_k127_3150445_18	1123267.JONN01000001_gene746	7.544e-33	129.0	2C7TH@1|root,32RJS@2|Bacteria,1MZK8@1224|Proteobacteria,2UC2R@28211|Alphaproteobacteria,2K5XZ@204457|Sphingomonadales	204457|Sphingomonadales	S	ETC complex I subunit	-	-	-	-	-	-	-	-	-	-	-	-	ETC_C1_NDUFA4
HKD2_k127_3150445_0	1123267.JONN01000001_gene747	0.0	1169.0	COG1643@1|root,COG1643@2|Bacteria,1MUEQ@1224|Proteobacteria,2TRMJ@28211|Alphaproteobacteria,2K0GM@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent helicase	hrpB	-	3.6.4.13	ko:K03579	-	-	-	-	ko00000,ko01000	-	-	-	DEAD,HA2,Helicase_C,HrpB_C
HKD2_k127_3150445_9	1123269.NX02_00925	1.823e-160	511.0	COG0142@1|root,COG0142@2|Bacteria,1MUK6@1224|Proteobacteria,2TSDZ@28211|Alphaproteobacteria,2JZY9@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the FPP GGPP synthase family	-	-	2.5.1.90	ko:K02523	ko00900,ko01110,map00900,map01110	-	R09248	RC00279	ko00000,ko00001,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_3150445_1	1123267.JONN01000001_gene754	0.0	1095.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M13	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD2_k127_3150445_7	1123267.JONN01000001_gene756	2.199e-193	616.0	COG0642@1|root,COG0642@2|Bacteria,1MX6R@1224|Proteobacteria,2TS9N@28211|Alphaproteobacteria,2K1P6@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	2CSK_N,HATPase_c
HKD2_k127_3150445_12	1123267.JONN01000001_gene757	2.193e-135	432.0	COG0745@1|root,COG0745@2|Bacteria,1N0YI@1224|Proteobacteria,2TSV8@28211|Alphaproteobacteria,2K0M9@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_3150445_19	1123267.JONN01000001_gene758	7.529e-25	108.0	29288@1|root,2ZPSV@2|Bacteria,1NJAG@1224|Proteobacteria,2UMCR@28211|Alphaproteobacteria,2K6S1@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PepSY
HKD2_k127_3150445_2	1123267.JONN01000001_gene759	5.784e-299	925.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TR3X@28211|Alphaproteobacteria,2K0QQ@204457|Sphingomonadales	204457|Sphingomonadales	S	of ABC transporters with duplicated ATPase	-	-	-	ko:K15738	-	-	-	-	ko00000,ko02000	3.A.1.120.6	-	-	ABC_tran,ABC_tran_CTD
HKD2_k127_3150445_3	1123267.JONN01000001_gene761	3.07e-270	844.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0TH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_3150445_6	1123267.JONN01000001_gene764	1.69e-216	684.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2K0MW@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	ko:K02481	-	-	-	-	ko00000,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_3150445_5	1123267.JONN01000001_gene765	2.165e-219	702.0	COG4191@1|root,COG4191@2|Bacteria,1MU55@1224|Proteobacteria,2TXJW@28211|Alphaproteobacteria,2KEK6@204457|Sphingomonadales	204457|Sphingomonadales	T	Domain present in phytochromes and cGMP-specific phosphodiesterases.	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c
HKD2_k127_3150445_8	1123269.NX02_22535	9.311e-182	578.0	COG1473@1|root,COG1473@2|Bacteria,1MUIV@1224|Proteobacteria,2TR5B@28211|Alphaproteobacteria,2K0AI@204457|Sphingomonadales	204457|Sphingomonadales	S	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_3150445_16	685778.AORL01000019_gene1724	1.794e-54	198.0	2E21J@1|root,32X9B@2|Bacteria,1N5A7@1224|Proteobacteria,2UF1K@28211|Alphaproteobacteria,2K5FT@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4893)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4893
HKD2_k127_3150445_13	1030157.AFMP01000044_gene1781	1.856e-118	386.0	COG1028@1|root,COG1028@2|Bacteria,1MU5Y@1224|Proteobacteria,2TRNQ@28211|Alphaproteobacteria,2K16P@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	1.1.1.30	ko:K00019	ko00072,ko00650,ko01100,map00072,map00650,map01100	M00088	R01361	RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HKD2_k127_3150445_15	1335760.ASTG01000001_gene3101	4.26e-99	332.0	COG2321@1|root,COG2321@2|Bacteria,1MU4U@1224|Proteobacteria,2TRCS@28211|Alphaproteobacteria,2K20W@204457|Sphingomonadales	204457|Sphingomonadales	S	metalloprotease	-	-	-	ko:K07054	-	-	-	-	ko00000	-	-	-	Zn_peptidase
HKD2_k127_3150445_11	1123267.JONN01000001_gene770	6.352e-139	448.0	COG2130@1|root,COG2130@2|Bacteria,1MUC2@1224|Proteobacteria,2TQYM@28211|Alphaproteobacteria,2K21X@204457|Sphingomonadales	204457|Sphingomonadales	L	alcohol dehydrogenase	-	-	-	ko:K07119	-	-	-	-	ko00000	-	-	-	ADH_N_2,ADH_zinc_N
HKD2_k127_3150445_17	685778.AORL01000019_gene1786	3.493e-48	187.0	COG3798@1|root,COG3798@2|Bacteria,1N0BJ@1224|Proteobacteria,2UDJF@28211|Alphaproteobacteria,2KE5H@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HKD2_k127_3150445_10	1037409.BJ6T_52880	1.41e-151	484.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2TRJH@28211|Alphaproteobacteria,3JTEW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Sulfatase-modifying factor enzyme 1	-	-	-	-	-	-	-	-	-	-	-	-	FGE-sulfatase
HKD2_k127_3150445_4	1454004.AW11_02009	7.646e-220	687.0	COG3119@1|root,COG3119@2|Bacteria,1MV92@1224|Proteobacteria,2VIFW@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Pfam Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_3185446_5	1174684.EBMC1_04469	3.376e-53	193.0	2ANEF@1|root,31DD2@2|Bacteria,1RHST@1224|Proteobacteria,2UA6U@28211|Alphaproteobacteria,2K5G6@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3185446_4	555793.WSK_2520	9.966e-88	293.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,2K0G8@204457|Sphingomonadales	204457|Sphingomonadales	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_3185446_3	279238.Saro_0267	8.412e-98	322.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,2K0QK@204457|Sphingomonadales	204457|Sphingomonadales	S	to the N-terminal domain of Lon protease	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HKD2_k127_3185446_0	1096930.L284_10200	1.674e-139	448.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2K0HB@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_15,TPR_19,TPR_20,Thioredoxin
HKD2_k127_3185446_7	1347086.CCBA010000012_gene2030	1.948e-06	51.0	2AWWM@1|root,31NU5@2|Bacteria,1TZQ8@1239|Firmicutes,4II4F@91061|Bacilli,1ZJ4J@1386|Bacillus	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3185446_6	158500.BV97_03160	1.472e-41	154.0	COG1813@1|root,COG1813@2|Bacteria,1QVBI@1224|Proteobacteria,2TWXC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_3185446_2	861208.AGROH133_14584	3.163e-100	329.0	COG5340@1|root,COG5340@2|Bacteria,1P6MT@1224|Proteobacteria,2U238@28211|Alphaproteobacteria,4BDNT@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator, AbiEi antitoxin	-	-	-	-	-	-	-	-	-	-	-	-	AbiEi_3_N,AbiEi_4
HKD2_k127_3185446_1	1040986.ATYO01000030_gene3475	1.277e-111	366.0	COG2253@1|root,COG2253@2|Bacteria,1NJT9@1224|Proteobacteria,2U243@28211|Alphaproteobacteria,43Q19@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD2_k127_3207800_35	46429.BV95_00714	9.164e-37	142.0	COG3549@1|root,COG3549@2|Bacteria,1N5NE@1224|Proteobacteria,2UG8H@28211|Alphaproteobacteria,2KDH4@204457|Sphingomonadales	204457|Sphingomonadales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	-	-	-	-	-	-	-	-	-	HigB-like_toxin
HKD2_k127_3207800_37	46429.BV95_00715	1.044e-33	133.0	COG3093@1|root,COG3093@2|Bacteria,1N590@1224|Proteobacteria,2UHGC@28211|Alphaproteobacteria,2K6WB@204457|Sphingomonadales	204457|Sphingomonadales	K	TIGRFAM addiction module antidote protein, HigA family	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	CENP-B_N
HKD2_k127_3207800_41	517722.AEUE01000001_gene2446	2.849e-22	107.0	COG3677@1|root,COG3677@2|Bacteria,1MXYX@1224|Proteobacteria,2TQR3@28211|Alphaproteobacteria,2K3A6@204457|Sphingomonadales	204457|Sphingomonadales	L	ISXO2-like transposase domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS1595,Zn_Tnp_IS1595
HKD2_k127_3207800_31	1169143.KB911034_gene1086	4.263e-61	220.0	COG3548@1|root,COG3548@2|Bacteria,1R9WQ@1224|Proteobacteria,2VQBM@28216|Betaproteobacteria,1K0DT@119060|Burkholderiaceae	28216|Betaproteobacteria	S	Protein of unknown function (DUF1211)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1211
HKD2_k127_3207800_23	1123267.JONN01000001_gene1765	5.227e-90	305.0	COG5405@1|root,COG5405@2|Bacteria,1MVF2@1224|Proteobacteria,2TRRE@28211|Alphaproteobacteria,2K0IZ@204457|Sphingomonadales	204457|Sphingomonadales	O	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery	hslV	-	3.4.25.2	ko:K01419	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Proteasome
HKD2_k127_3207800_14	1120705.FG95_03100	5.012e-138	447.0	COG0665@1|root,COG0665@2|Bacteria,1Q9VR@1224|Proteobacteria,2U05R@28211|Alphaproteobacteria,2K32V@204457|Sphingomonadales	204457|Sphingomonadales	E	D-amino acid	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD2_k127_3207800_5	1123267.JONN01000001_gene1766	1.266e-221	703.0	COG1220@1|root,COG1220@2|Bacteria,1MVK9@1224|Proteobacteria,2TRXC@28211|Alphaproteobacteria,2K0UP@204457|Sphingomonadales	204457|Sphingomonadales	O	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis	hslU	-	-	ko:K03667	-	-	-	-	ko00000,ko03110	-	-	-	AAA_2,ClpB_D2-small
HKD2_k127_3207800_40	1547437.LL06_00610	7.509e-23	104.0	COG3812@1|root,COG3812@2|Bacteria,1RGUV@1224|Proteobacteria,2U9BA@28211|Alphaproteobacteria,43M0F@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain of unknown function (DUF1993)	-	-	-	ko:K09983	-	-	-	-	ko00000	-	-	-	DUF1993
HKD2_k127_3207800_28	1123267.JONN01000001_gene1768	7.917e-77	263.0	2BXI0@1|root,2Z9A2@2|Bacteria,1MZF7@1224|Proteobacteria,2UCIX@28211|Alphaproteobacteria,2K3UM@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2459)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2459
HKD2_k127_3207800_36	1123267.JONN01000001_gene1769	2.025e-34	136.0	COG1862@1|root,COG1862@2|Bacteria,1MZT2@1224|Proteobacteria,2UBZ6@28211|Alphaproteobacteria,2K62B@204457|Sphingomonadales	204457|Sphingomonadales	U	Preprotein translocase subunit YajC	yajC	-	-	ko:K03210	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	YajC
HKD2_k127_3207800_3	1123267.JONN01000001_gene1770	3.854e-229	721.0	COG0342@1|root,COG0342@2|Bacteria,1MV5U@1224|Proteobacteria,2TQYG@28211|Alphaproteobacteria,2K1DA@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secD	-	-	ko:K03072	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_3207800_15	1123267.JONN01000001_gene1771	1.005e-129	432.0	COG0341@1|root,COG0341@2|Bacteria,1MU74@1224|Proteobacteria,2TSFW@28211|Alphaproteobacteria,2K18K@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA	secF	-	-	ko:K03074	ko03060,ko03070,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	2.A.6.4,3.A.5.2,3.A.5.7	-	-	SecD_SecF,Sec_GG
HKD2_k127_3207800_21	1123267.JONN01000001_gene1772	4.933e-109	361.0	COG4105@1|root,COG4105@2|Bacteria,1MVS5@1224|Proteobacteria,2TRZ5@28211|Alphaproteobacteria,2JZVK@204457|Sphingomonadales	204457|Sphingomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamD	-	-	ko:K05807	-	-	-	-	ko00000,ko02000	1.B.33.1	-	-	YfiO
HKD2_k127_3207800_7	1123267.JONN01000001_gene1773	1.061e-206	661.0	COG0497@1|root,COG0497@2|Bacteria,1MUNP@1224|Proteobacteria,2TREW@28211|Alphaproteobacteria,2K043@204457|Sphingomonadales	204457|Sphingomonadales	L	May be involved in recombinational repair of damaged DNA	recN	-	-	ko:K03631	-	-	-	-	ko00000,ko03400	-	-	-	SMC_N
HKD2_k127_3207800_25	1123267.JONN01000001_gene1774	2.186e-83	283.0	COG0412@1|root,COG0412@2|Bacteria,1RJ0Q@1224|Proteobacteria,2UBJ9@28211|Alphaproteobacteria,2KDGK@204457|Sphingomonadales	204457|Sphingomonadales	Q	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DLH
HKD2_k127_3207800_2	1123267.JONN01000001_gene1776	0.0	1050.0	COG0272@1|root,COG0272@2|Bacteria,1MV3R@1224|Proteobacteria,2TRHK@28211|Alphaproteobacteria,2K00E@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA	ligA	-	6.5.1.2	ko:K01972	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00382	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	BRCT,DNA_ligase_OB,DNA_ligase_ZBD,DNA_ligase_aden,HHH_2
HKD2_k127_3207800_4	392499.Swit_3119	1.939e-224	709.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S10 serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HKD2_k127_3207800_32	1333998.M2A_2407	2.649e-41	164.0	COG1247@1|root,COG1247@2|Bacteria,1NKJU@1224|Proteobacteria,2UH94@28211|Alphaproteobacteria,4BSGU@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	M	Acetyltransferase (GNAT) domain	-	-	-	ko:K03830	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
HKD2_k127_3207800_17	1123267.JONN01000001_gene1778	4.675e-114	375.0	COG2264@1|root,COG2264@2|Bacteria,1MUPC@1224|Proteobacteria,2TTP3@28211|Alphaproteobacteria,2K0Q7@204457|Sphingomonadales	204457|Sphingomonadales	J	ribosomal protein L11	prmA	-	-	ko:K02687	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PrmA
HKD2_k127_3207800_22	1123267.JONN01000001_gene1779	5.488e-99	332.0	COG0491@1|root,COG0491@2|Bacteria,1P5NJ@1224|Proteobacteria,2TRXW@28211|Alphaproteobacteria,2K1DS@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	3.5.2.6	ko:K17837	ko01501,map01501	-	R06363	RC01499	ko00000,ko00001,ko01000	-	-	-	Lactamase_B
HKD2_k127_3207800_39	287.DR97_4805	8.273e-26	115.0	COG1028@1|root,COG1028@2|Bacteria,1MW9A@1224|Proteobacteria,1RMMZ@1236|Gammaproteobacteria,1YEDI@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	IQ	KR domain	ygfF	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_3207800_18	1123267.JONN01000001_gene1781	2.892e-113	380.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K1AE@204457|Sphingomonadales	204457|Sphingomonadales	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HKD2_k127_3207800_33	392499.Swit_1312	3.737e-41	155.0	COG2009@1|root,COG2009@2|Bacteria,1N02N@1224|Proteobacteria,2UC47@28211|Alphaproteobacteria,2K6ED@204457|Sphingomonadales	204457|Sphingomonadales	C	succinate dehydrogenase	sdhC	-	-	ko:K00241	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_3207800_38	1144307.PMI04_02910	1.984e-26	119.0	COG2142@1|root,COG2142@2|Bacteria,1MZND@1224|Proteobacteria,2UC3G@28211|Alphaproteobacteria,2K550@204457|Sphingomonadales	204457|Sphingomonadales	C	succinate dehydrogenase	sdhD	-	-	ko:K00242	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173	R02164	RC00045	ko00000,ko00001,ko00002	-	-	-	Sdh_cyt
HKD2_k127_3207800_0	1123267.JONN01000001_gene1784	0.0	1084.0	COG1053@1|root,COG1053@2|Bacteria,1MU5M@1224|Proteobacteria,2TQJA@28211|Alphaproteobacteria,2K1NE@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the FAD-dependent oxidoreductase 2 family. FRD SDH subfamily	sdhA	-	1.3.5.1,1.3.5.4	ko:K00239	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko05134,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200,map05134	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_3207800_1	78245.Xaut_3044	0.0	1072.0	COG3256@1|root,COG3256@2|Bacteria,1MVT1@1224|Proteobacteria,2TUJ1@28211|Alphaproteobacteria,3F1W0@335928|Xanthobacteraceae	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	norB	-	1.7.2.5	ko:K04561	ko00910,ko01120,map00910,map01120	M00529	R00294	RC02794	ko00000,ko00001,ko00002,ko01000	3.D.4.10	-	-	COX1
HKD2_k127_3207800_29	1123073.KB899244_gene350	2.616e-74	261.0	COG0491@1|root,COG0491@2|Bacteria,1QBJF@1224|Proteobacteria,1T752@1236|Gammaproteobacteria,1X8SQ@135614|Xanthomonadales	135614|Xanthomonadales	S	Metallo-beta-lactamase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_3207800_30	1123267.JONN01000001_gene1851	2.987e-67	240.0	COG0663@1|root,COG0663@2|Bacteria,1RD76@1224|Proteobacteria,2U5GR@28211|Alphaproteobacteria,2K4AW@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hexapep
HKD2_k127_3207800_44	1123261.AXDW01000009_gene136	7.025e-10	64.0	2ESJ3@1|root,33K3T@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABM
HKD2_k127_3207800_19	1123267.JONN01000001_gene1758	2.053e-111	369.0	COG0702@1|root,COG0702@2|Bacteria,1MW54@1224|Proteobacteria,2TQMD@28211|Alphaproteobacteria,2K19R@204457|Sphingomonadales	204457|Sphingomonadales	GM	Dehydrogenase	-	-	1.6.5.3,1.6.99.3	ko:K00329,ko:K00356	ko00190,map00190	-	R11945	RC00061	ko00000,ko00001,ko01000	-	-	-	3Beta_HSD,Epimerase,NAD_binding_10,RmlD_sub_bind
HKD2_k127_3207800_20	1081640.AGFU01000006_gene1203	6.192e-111	364.0	COG1968@1|root,COG1968@2|Bacteria,1MX02@1224|Proteobacteria,2TSUR@28211|Alphaproteobacteria,2K0R1@204457|Sphingomonadales	204457|Sphingomonadales	V	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin	uppP	-	3.6.1.27	ko:K06153	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	BacA
HKD2_k127_3207800_16	1123267.JONN01000001_gene1824	6.427e-125	402.0	COG0625@1|root,COG0625@2|Bacteria,1MXM4@1224|Proteobacteria,2TTXD@28211|Alphaproteobacteria,2K1DG@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_3207800_24	1123269.NX02_21170	1.84e-88	299.0	COG2227@1|root,COG2227@2|Bacteria,1MU89@1224|Proteobacteria,2TRIK@28211|Alphaproteobacteria,2K0DH@204457|Sphingomonadales	204457|Sphingomonadales	H	O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway	ubiG	-	2.1.1.222,2.1.1.64	ko:K00568	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04988,R05614,R08769,R08781	RC00003,RC00392,RC01895	ko00000,ko00001,ko00002,ko01000	-	-	-	Methyltransf_11,Methyltransf_23
HKD2_k127_3207800_10	59538.XP_005981295.1	3.866e-170	546.0	COG0019@1|root,KOG0622@2759|Eukaryota,39SQ5@33154|Opisthokonta,3BMMM@33208|Metazoa,3D2VJ@33213|Bilateria,48JNB@7711|Chordata	33208|Metazoa	E	Alanine racemase, N-terminal domain	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_3207800_6	1123267.JONN01000001_gene1819	1.358e-207	655.0	COG0527@1|root,COG0527@2|Bacteria,1MW3H@1224|Proteobacteria,2TRFA@28211|Alphaproteobacteria,2K044@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the aspartokinase family	lysC	-	2.7.2.4	ko:K00928	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01210,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01210,map01230	M00016,M00017,M00018,M00033,M00525,M00526,M00527	R00480	RC00002,RC00043	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,ACT,ACT_7
HKD2_k127_3207800_11	1123267.JONN01000001_gene1818	3.397e-167	533.0	COG2070@1|root,COG2070@2|Bacteria,1MWPC@1224|Proteobacteria,2TQRT@28211|Alphaproteobacteria,2K0DQ@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	1.3.1.9	ko:K02371	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00083	R04429,R04724,R04955,R04958,R04961,R04966,R04969,R07765	RC00052,RC00076	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	NMO,ThiG
HKD2_k127_3207800_42	1101188.KI912155_gene3220	3.696e-19	91.0	COG3631@1|root,COG3631@2|Bacteria,2IJVZ@201174|Actinobacteria	201174|Actinobacteria	S	Ketosteroid isomerase-related protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3207800_13	1007104.SUS17_3878	1.97e-139	450.0	COG3384@1|root,COG3384@2|Bacteria,1MXJZ@1224|Proteobacteria,2TRJT@28211|Alphaproteobacteria,2K0K2@204457|Sphingomonadales	204457|Sphingomonadales	S	dioxygenase	-	-	-	ko:K15777	ko00965,map00965	-	R08836	RC00387	ko00000,ko00001,ko01000	-	-	-	LigB
HKD2_k127_3207800_12	318996.AXAZ01000044_gene2099	6.416e-146	478.0	COG1073@1|root,COG1926@1|root,COG1073@2|Bacteria,COG1926@2|Bacteria,1RAG8@1224|Proteobacteria,2U5HS@28211|Alphaproteobacteria,3JYIY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Phosphoribosyl transferase domain	-	-	-	ko:K07100	-	-	-	-	ko00000	-	-	-	Pribosyltran
HKD2_k127_3207800_26	1131812.JQMS01000001_gene1971	2.006e-79	272.0	COG1028@1|root,COG1028@2|Bacteria,4NGQY@976|Bacteroidetes,1HZ7N@117743|Flavobacteriia,2NTZG@237|Flavobacterium	976|Bacteroidetes	IQ	short-chain dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD2_k127_3207800_34	1304275.C41B8_00915	8.049e-41	156.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST,RimK
HKD2_k127_3207800_8	1197906.CAJQ02000001_gene2638	2.234e-191	610.0	COG1236@1|root,COG1236@2|Bacteria,1MUDD@1224|Proteobacteria,2TVFM@28211|Alphaproteobacteria,3JVKB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	J	Beta-Casp domain	-	-	-	ko:K07576	-	-	-	-	ko00000	-	-	-	Beta-Casp,Lactamase_B,RMMBL
HKD2_k127_3207800_27	1038866.KB902773_gene804	3.695e-77	269.0	COG0462@1|root,COG0462@2|Bacteria,1MUV7@1224|Proteobacteria,2U3AB@28211|Alphaproteobacteria,3JVN2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	N-terminal domain of ribose phosphate pyrophosphokinase	-	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran,Pribosyltran_N
HKD2_k127_3207800_9	1114964.L485_18300	4.994e-176	567.0	COG0213@1|root,COG0213@2|Bacteria,1MV3H@1224|Proteobacteria,2TS24@28211|Alphaproteobacteria,2K39V@204457|Sphingomonadales	204457|Sphingomonadales	F	Thymidine phosphorylase	-	-	2.4.2.4	ko:K00758	ko00240,ko00983,ko01100,ko05219,map00240,map00983,map01100,map05219	-	R01570,R02484,R08222,R08230	RC00063	ko00000,ko00001,ko01000	-	-	-	Glycos_trans_3N,Glycos_transf_3,PYNP_C
HKD2_k127_3327467_3	1123267.JONN01000001_gene1985	9.727e-10	62.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_3327467_2	237727.NAP1_09812	2.116e-40	156.0	COG1695@1|root,COG1695@2|Bacteria,1PCI9@1224|Proteobacteria,2V1YM@28211|Alphaproteobacteria,2KC7X@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_3327467_4	1121022.ABENE_22485	2.956e-09	64.0	COG3682@1|root,COG3682@2|Bacteria,1N95N@1224|Proteobacteria,2UISP@28211|Alphaproteobacteria,2KHJ9@204458|Caulobacterales	204458|Caulobacterales	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD2_k127_3327467_1	314254.OA2633_05701	2.02e-57	209.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria,4401U@69657|Hyphomonadaceae	28211|Alphaproteobacteria	T	LytTr DNA-binding domain	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_3327467_0	13689.BV96_03735	1.809e-64	234.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria,2K0W4@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HKD2_k127_3375556_4	1385517.N800_01230	1.288e-24	104.0	COG0460@1|root,COG0460@2|Bacteria,1MUDC@1224|Proteobacteria,1RPEU@1236|Gammaproteobacteria,1X5F4@135614|Xanthomonadales	135614|Xanthomonadales	E	homoserine dehydrogenase	metL	-	1.1.1.3,2.7.2.4	ko:K00003,ko:K12524	ko00260,ko00261,ko00270,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map00261,map00270,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00017,M00018,M00526,M00527	R00480,R01773,R01775	RC00002,RC00043,RC00087	ko00000,ko00001,ko00002,ko01000	-	-	-	Homoserine_dh,NAD_binding_3
HKD2_k127_3375556_7	161528.ED21_25688	1.12e-09	68.0	2DHGE@1|root,2ZZNG@2|Bacteria,1P6PN@1224|Proteobacteria,2UY72@28211|Alphaproteobacteria,2KBU8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_3375556_1	757424.Hsero_3591	7.091e-37	147.0	COG0454@1|root,COG0456@2|Bacteria,1RI35@1224|Proteobacteria,2VSGM@28216|Betaproteobacteria,47535@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03827	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_10
HKD2_k127_3375556_3	1214065.BAGV01000023_gene2810	3.635e-32	138.0	COG1276@1|root,COG1276@2|Bacteria,1P1D5@1224|Proteobacteria,1RYS7@1236|Gammaproteobacteria	1236|Gammaproteobacteria	P	copper resistance protein	yebZ	GO:0005575,GO:0005623,GO:0005886,GO:0016020,GO:0044464,GO:0071944	-	ko:K07245	-	-	-	-	ko00000,ko02000	9.B.62.1	-	-	CopD
HKD2_k127_3375556_5	460265.Mnod_6630	2.184e-23	104.0	COG2372@1|root,COG2372@2|Bacteria,1N8SS@1224|Proteobacteria,2UFW5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Copper resistance protein	copC	-	-	ko:K07156	-	-	-	-	ko00000,ko02000	9.B.62.2	-	-	CopC
HKD2_k127_3375556_0	1038867.AXAY01000003_gene3039	4.392e-74	263.0	28HTF@1|root,2Z80A@2|Bacteria,1PEXH@1224|Proteobacteria,2TTDP@28211|Alphaproteobacteria,3JWDE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3375556_2	685778.AORL01000002_gene1946	1.673e-34	138.0	COG1522@1|root,COG1522@2|Bacteria,1RCEQ@1224|Proteobacteria,2U6I5@28211|Alphaproteobacteria,2K497@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	ko:K05800	-	-	-	-	ko00000,ko03000	-	-	-	AsnC_trans_reg,HTH_24
HKD2_k127_3375556_6	1123267.JONN01000001_gene1971	5.081e-16	83.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_3401037_38	450851.PHZ_c2104	1.457e-25	111.0	COG5397@1|root,COG5397@2|Bacteria,1PJM3@1224|Proteobacteria,2U1M6@28211|Alphaproteobacteria,2KGXJ@204458|Caulobacterales	204458|Caulobacterales	S	Nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_8
HKD2_k127_3401037_9	1123267.JONN01000002_gene29	6.833e-170	548.0	COG0508@1|root,COG0508@2|Bacteria,1R0J5@1224|Proteobacteria,2U28K@28211|Alphaproteobacteria,2K8XE@204457|Sphingomonadales	204457|Sphingomonadales	C	2-oxoacid dehydrogenases acyltransferase (catalytic domain)	-	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_3401037_0	1123267.JONN01000002_gene27	0.0	1104.0	COG0022@1|root,COG1071@1|root,COG0022@2|Bacteria,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2V929@28211|Alphaproteobacteria,2K9IC@204457|Sphingomonadales	204457|Sphingomonadales	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.4	ko:K11381	ko00280,ko00640,ko01100,ko01110,ko01130,map00280,map00640,map01100,map01110,map01130	M00036	R07599,R07600,R07601,R07602,R07603,R07604,R10996,R10997	RC00027,RC00627,RC02743,RC02883,RC02949,RC02953	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh,Transket_pyr,Transketolase_C
HKD2_k127_3401037_10	1123267.JONN01000002_gene26	4.525e-164	526.0	COG1448@1|root,COG1448@2|Bacteria,1MUT0@1224|Proteobacteria,2TS9C@28211|Alphaproteobacteria,2K0UV@204457|Sphingomonadales	204457|Sphingomonadales	E	PFAM Aminotransferase class I and II	-	-	2.6.1.57	ko:K00832	ko00270,ko00350,ko00360,ko00400,ko00401,ko00950,ko00960,ko01100,ko01110,ko01130,ko01230,map00270,map00350,map00360,map00400,map00401,map00950,map00960,map01100,map01110,map01130,map01230	M00024,M00025,M00034,M00040	R00694,R00734,R01731,R07396,R10845	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_1_2
HKD2_k127_3401037_11	1123267.JONN01000002_gene25	2.508e-158	507.0	COG1018@1|root,COG1018@2|Bacteria,1MY2Q@1224|Proteobacteria,2U0WY@28211|Alphaproteobacteria,2K3BZ@204457|Sphingomonadales	204457|Sphingomonadales	C	Oxidoreductase FAD-binding domain	-	-	1.17.1.1	ko:K00523,ko:K02613	ko00360,ko00520,ko01120,map00360,map00520,map01120	-	R03391,R03392,R09838	RC00230,RC02690	ko00000,ko00001,ko01000	-	-	-	FAD_binding_6,Fer2,NAD_binding_1
HKD2_k127_3401037_18	1123267.JONN01000002_gene24	7.219e-114	373.0	COG3396@1|root,COG3396@2|Bacteria,1MVYQ@1224|Proteobacteria,2TRYF@28211|Alphaproteobacteria,2JZUF@204457|Sphingomonadales	204457|Sphingomonadales	S	Phenylacetic acid catabolic protein	-	-	1.14.13.149	ko:K02611	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD2_k127_3401037_28	392499.Swit_0754	7.157e-49	178.0	COG3460@1|root,COG3460@2|Bacteria,1RHM5@1224|Proteobacteria,2U9HF@28211|Alphaproteobacteria,2K5PV@204457|Sphingomonadales	204457|Sphingomonadales	Q	Phenylacetic acid degradation B	-	-	-	ko:K02610	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	PaaB
HKD2_k127_3401037_7	1123267.JONN01000002_gene22	3.868e-194	607.0	COG3396@1|root,COG3396@2|Bacteria,1MVQ7@1224|Proteobacteria,2TTC4@28211|Alphaproteobacteria,2K27K@204457|Sphingomonadales	204457|Sphingomonadales	S	Phenylacetic acid catabolic protein	-	-	1.14.13.149	ko:K02609	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001,ko01000	-	-	-	PaaA_PaaC
HKD2_k127_3401037_31	1088721.NSU_3805	6.683e-39	154.0	COG2050@1|root,COG2050@2|Bacteria,1RH35@1224|Proteobacteria,2U5QW@28211|Alphaproteobacteria,2K6MG@204457|Sphingomonadales	204457|Sphingomonadales	Q	Thioesterase superfamily	-	-	-	ko:K02614	ko00360,map00360	-	R09840	RC00004,RC00014	ko00000,ko00001,ko01000	-	-	-	4HBT
HKD2_k127_3401037_17	1123267.JONN01000002_gene224	4.237e-118	392.0	COG1024@1|root,COG1024@2|Bacteria,1MVQN@1224|Proteobacteria,2TUXD@28211|Alphaproteobacteria,2K0UE@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	5.3.3.18	ko:K15866	ko00360,ko01120,map00360,map01120	-	R09837,R09839	RC00004,RC00326,RC02689,RC03003	ko00000,ko00001,ko01000	-	-	-	ECH_1
HKD2_k127_3401037_13	1112216.JH594426_gene3803	4.705e-135	438.0	COG3173@1|root,COG3173@2|Bacteria,1MWAK@1224|Proteobacteria,2TT2N@28211|Alphaproteobacteria,2K142@204457|Sphingomonadales	204457|Sphingomonadales	S	Aminoglycoside phosphotransferase	-	-	-	-	-	-	-	-	-	-	-	-	APH
HKD2_k127_3401037_5	745310.G432_10750	3.965e-207	650.0	COG1960@1|root,COG1960@2|Bacteria,1MU2V@1224|Proteobacteria,2TSK3@28211|Alphaproteobacteria,2JZVP@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_3401037_21	1123267.JONN01000001_gene1732	7.442e-93	313.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_3401037_27	291985.CCSI01000003_gene29	1.229e-49	185.0	COG0484@1|root,COG0484@2|Bacteria,1RHHJ@1224|Proteobacteria,2UEFM@28211|Alphaproteobacteria,2K663@204457|Sphingomonadales	204457|Sphingomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	ko:K05516	-	-	-	-	ko00000,ko03036,ko03110	-	-	-	DnaJ
HKD2_k127_3401037_41	1429916.X566_23875	1.653e-19	101.0	2CIPC@1|root,2Z9HB@2|Bacteria,1R3W8@1224|Proteobacteria,2TST7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Glycosyltransferase family 87	-	-	-	-	-	-	-	-	-	-	-	-	GT87
HKD2_k127_3401037_16	745310.G432_08360	9.764e-123	407.0	COG3555@1|root,COG3555@2|Bacteria,1MXZE@1224|Proteobacteria,2U0S2@28211|Alphaproteobacteria,2K0VK@204457|Sphingomonadales	204457|Sphingomonadales	O	Aspartyl/Asparaginyl beta-hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Arg_Hydrox
HKD2_k127_3401037_22	234267.Acid_2317	4.373e-84	293.0	COG1171@1|root,COG1171@2|Bacteria,3Y2RI@57723|Acidobacteria	57723|Acidobacteria	E	beta' subunit	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP,Thr_dehydrat_C
HKD2_k127_3401037_23	1144307.PMI04_00844	1.193e-73	269.0	COG2246@1|root,COG2246@2|Bacteria,1QUSS@1224|Proteobacteria,2TW63@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	polysaccharide biosynthetic process	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3401037_2	1123267.JONN01000002_gene222	0.0	1073.0	COG1012@1|root,COG2030@1|root,COG1012@2|Bacteria,COG2030@2|Bacteria,1MWD4@1224|Proteobacteria,2TUPI@28211|Alphaproteobacteria,2K1V8@204457|Sphingomonadales	204457|Sphingomonadales	CI	MaoC like domain	-	-	1.2.1.91,3.3.2.12	ko:K02618	ko00360,ko01120,map00360,map01120	-	R09820,R09836	RC00080,RC02667	ko00000,ko00001,ko01000	-	-	-	Aldedh,MaoC_dehydratas
HKD2_k127_3401037_32	266779.Meso_2788	1.51e-37	149.0	COG0517@1|root,COG0517@2|Bacteria,1NMH1@1224|Proteobacteria,2U9D8@28211|Alphaproteobacteria,43M98@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	Domain in cystathionine beta-synthase and other proteins.	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_3401037_30	1123267.JONN01000002_gene221	6.227e-42	160.0	COG0711@1|root,COG0711@2|Bacteria,1N0P5@1224|Proteobacteria,2U5DD@28211|Alphaproteobacteria,2K57Z@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF_2	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_3401037_34	392499.Swit_4485	1.564e-35	141.0	COG0711@1|root,COG0711@2|Bacteria,1MZGU@1224|Proteobacteria,2UBVW@28211|Alphaproteobacteria,2K5D0@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)	atpF_1	-	-	ko:K02109	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_B
HKD2_k127_3401037_39	1174684.EBMC1_09199	1.469e-25	107.0	COG0636@1|root,COG0636@2|Bacteria,1MZBU@1224|Proteobacteria,2UFPN@28211|Alphaproteobacteria,2K61N@204457|Sphingomonadales	204457|Sphingomonadales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpE	-	-	ko:K02110	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_C
HKD2_k127_3401037_19	1502850.FG91_02432	1.238e-106	351.0	COG0356@1|root,COG0356@2|Bacteria,1MV87@1224|Proteobacteria,2TRNV@28211|Alphaproteobacteria,2K17B@204457|Sphingomonadales	204457|Sphingomonadales	C	it plays a direct role in the translocation of protons across the membrane	atpB	-	-	ko:K02108	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko03110	3.A.2.1	-	-	ATP-synt_A
HKD2_k127_3401037_43	1123270.ATUR01000002_gene2704	2.087e-16	84.0	COG5336@1|root,COG5336@2|Bacteria,1N2ME@1224|Proteobacteria,2UCBR@28211|Alphaproteobacteria,2K62W@204457|Sphingomonadales	204457|Sphingomonadales	S	function for this protein is to guide the assembly of the membrane sector of the ATPase enzyme complex	atpI	-	-	ko:K02116	-	-	-	-	ko00000,ko00194	3.A.2.1	-	-	ATPase_gene1
HKD2_k127_3401037_29	1123267.JONN01000002_gene216	1.458e-45	175.0	2ANQE@1|root,31DQ0@2|Bacteria,1MWJD@1224|Proteobacteria,2U7P7@28211|Alphaproteobacteria,2K5A1@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4163)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4163
HKD2_k127_3401037_37	1123267.JONN01000002_gene215	1.605e-31	130.0	COG3784@1|root,COG3784@2|Bacteria,1Q09W@1224|Proteobacteria,2UCIH@28211|Alphaproteobacteria,2K5RZ@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09978	-	-	-	-	ko00000	-	-	-	DUF1318
HKD2_k127_3401037_3	1123267.JONN01000002_gene213	0.0	1048.0	COG2911@1|root,COG2911@2|Bacteria,1R6VP@1224|Proteobacteria,2U46Q@28211|Alphaproteobacteria,2KCIH@204457|Sphingomonadales	204457|Sphingomonadales	S	Dicarboxylate transport	-	-	-	-	-	-	-	-	-	-	-	-	DctA-YdbH
HKD2_k127_3401037_4	1123267.JONN01000002_gene208	3.781e-231	721.0	COG0015@1|root,COG0015@2|Bacteria,1MV4B@1224|Proteobacteria,2TQUE@28211|Alphaproteobacteria,2K0GV@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily	purB	-	4.3.2.2	ko:K01756	ko00230,ko00250,ko01100,ko01110,ko01130,map00230,map00250,map01100,map01110,map01130	M00048,M00049	R01083,R04559	RC00379,RC00444,RC00445	ko00000,ko00001,ko00002,ko01000	-	-	-	ADSL_C,Lyase_1
HKD2_k127_3401037_40	582899.Hden_0770	3.72e-20	100.0	COG3279@1|root,COG4251@1|root,COG3279@2|Bacteria,COG4251@2|Bacteria,1NSQ1@1224|Proteobacteria,2TWHG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	signal transduction histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HWE_HK,HisKA_3,PAS_2,PHY,Response_reg
HKD2_k127_3401037_12	1549858.MC45_10120	3.076e-147	474.0	COG0484@1|root,COG0484@2|Bacteria,1MVMS@1224|Proteobacteria,2TRZ1@28211|Alphaproteobacteria,2K1EY@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins	dnaJ	-	-	ko:K03686	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	DnaJ,DnaJ_C,DnaJ_CXXCXGXG
HKD2_k127_3401037_1	1123267.JONN01000002_gene202	0.0	1091.0	COG0443@1|root,COG0443@2|Bacteria,1MVEN@1224|Proteobacteria,2TR5H@28211|Alphaproteobacteria,2K1KK@204457|Sphingomonadales	204457|Sphingomonadales	O	Heat shock 70 kDa protein	dnaK	-	-	ko:K04043	ko03018,ko04212,ko05152,map03018,map04212,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	1.A.33.1	-	-	HSP70
HKD2_k127_3401037_15	1123267.JONN01000002_gene201	9.7e-124	399.0	COG1028@1|root,COG1028@2|Bacteria,1MU6X@1224|Proteobacteria,2TQZG@28211|Alphaproteobacteria,2K1MK@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	fabG	-	1.1.1.100	ko:K00059	ko00061,ko00333,ko00780,ko01040,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01040,map01100,map01130,map01212	M00083,M00572	R04533,R04534,R04536,R04543,R04566,R04953,R04964,R07759,R07763,R10116,R10120,R11671	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_3401037_14	194867.ALBQ01000027_gene2785	6.407e-130	422.0	COG0331@1|root,COG0331@2|Bacteria,1MV6N@1224|Proteobacteria,2TRTT@28211|Alphaproteobacteria,2K15H@204457|Sphingomonadales	204457|Sphingomonadales	I	malonyl CoA-acyl carrier protein transacylase	fabD	-	2.3.1.39	ko:K00645	ko00061,ko00333,ko01100,ko01130,ko01212,map00061,map00333,map01100,map01130,map01212	M00082	R01626,R11671	RC00004,RC00039,RC02727	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyl_transf_1
HKD2_k127_3401037_8	1123267.JONN01000002_gene199	3.866e-173	556.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TRWS@28211|Alphaproteobacteria,2K02K@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease_2
HKD2_k127_3401037_25	1174684.EBMC1_15734	3.15e-56	218.0	COG0531@1|root,COG0531@2|Bacteria,1MUA2@1224|Proteobacteria,2TRWS@28211|Alphaproteobacteria,2K02K@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_3401037_6	1123267.JONN01000002_gene198	7.638e-200	628.0	COG4638@1|root,COG4638@2|Bacteria,1MWXW@1224|Proteobacteria,2TSJ5@28211|Alphaproteobacteria,2K2R1@204457|Sphingomonadales	204457|Sphingomonadales	P	Ring hydroxylating alpha subunit (catalytic domain)	-	-	-	-	-	-	-	-	-	-	-	-	Rieske,Ring_hydroxyl_A
HKD2_k127_3401037_35	450851.PHZ_c1636	5.898e-35	139.0	COG1765@1|root,COG1765@2|Bacteria,1N2BT@1224|Proteobacteria,2TQN7@28211|Alphaproteobacteria,2KH9F@204458|Caulobacterales	204458|Caulobacterales	O	PFAM OsmC family protein	-	-	-	ko:K06889,ko:K07397	-	-	-	-	ko00000	-	-	-	Hydrolase_4,OsmC
HKD2_k127_3401037_36	1007104.SUS17_3133	1.673e-34	139.0	2DWID@1|root,340GN@2|Bacteria,1ND9Q@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3401037_26	1550073.JROH01000030_gene1107	9.107e-54	199.0	COG0360@1|root,COG0360@2|Bacteria,1RH82@1224|Proteobacteria,2U767@28211|Alphaproteobacteria,2K4F9@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds together with S18 to 16S ribosomal RNA	rpsF	-	-	ko:K02990	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S6
HKD2_k127_3401037_33	1123267.JONN01000001_gene619	2.333e-37	141.0	COG0238@1|root,COG0238@2|Bacteria,1MZ8U@1224|Proteobacteria,2UC13@28211|Alphaproteobacteria,2K5WV@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit	rpsR	-	-	ko:K02963	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S18
HKD2_k127_3401037_20	1123267.JONN01000001_gene618	3.872e-96	317.0	COG0359@1|root,COG0359@2|Bacteria,1RD0R@1224|Proteobacteria,2TSC9@28211|Alphaproteobacteria,2K0UT@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds to the 23S rRNA	rplI	-	-	ko:K02939	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L9_C,Ribosomal_L9_N
HKD2_k127_3401037_24	685778.AORL01000016_gene2326	2.148e-73	252.0	COG1396@1|root,COG1396@2|Bacteria,1RKW7@1224|Proteobacteria,2U9PU@28211|Alphaproteobacteria,2K2H6@204457|Sphingomonadales	204457|Sphingomonadales	K	XRE family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_3434606_1	1187851.A33M_0653	1.954e-168	531.0	COG0714@1|root,COG0714@2|Bacteria,1MV5I@1224|Proteobacteria,2TRI8@28211|Alphaproteobacteria,3FCRV@34008|Rhodovulum	28211|Alphaproteobacteria	O	AAA domain (Cdc48 subfamily)	MA20_01295	-	-	-	-	-	-	-	-	-	-	-	AAA,AAA_5
HKD2_k127_3434606_0	1040989.AWZU01000004_gene7073	2.902e-196	636.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3K2NJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_11,TPR_16,TPR_2,TPR_8
HKD2_k127_3434606_2	631454.N177_0490	2.574e-48	178.0	COG0229@1|root,COG0229@2|Bacteria,1RGWC@1224|Proteobacteria,2U70T@28211|Alphaproteobacteria,1JP1B@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	SelR domain	msrB1	-	1.8.4.12	ko:K07305	-	-	-	-	ko00000,ko01000	-	-	-	SelR
HKD2_k127_3474036_2	1224746.B932_0250	1.15e-44	166.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,2JS3T@204441|Rhodospirillales	204441|Rhodospirillales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_3474036_0	1123267.JONN01000001_gene1160	1.844e-171	560.0	COG4206@1|root,COG4206@2|Bacteria,1MW63@1224|Proteobacteria,2TT3G@28211|Alphaproteobacteria,2K12C@204457|Sphingomonadales	204457|Sphingomonadales	H	receptor	-	-	-	ko:K16092	-	-	-	-	ko00000,ko02000	1.B.14.3	-	-	Plug,TonB_dep_Rec
HKD2_k127_3474036_1	945713.IALB_2304	8.858e-46	171.0	2CBKC@1|root,32RTJ@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3474036_3	1123267.JONN01000001_gene1161	4.041e-36	138.0	COG0254@1|root,COG0254@2|Bacteria,1MZ69@1224|Proteobacteria,2UBSC@28211|Alphaproteobacteria,2K643@204457|Sphingomonadales	204457|Sphingomonadales	J	50S ribosomal protein L31	rpmE	-	-	ko:K02909	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L31
HKD2_k127_359951_1	1123267.JONN01000001_gene1121	2.323e-146	468.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,2K0Z9@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_359951_2	1123267.JONN01000001_gene1120	8.65e-125	404.0	COG0842@1|root,COG0842@2|Bacteria,1MUH1@1224|Proteobacteria,2TQSY@28211|Alphaproteobacteria,2JZWT@204457|Sphingomonadales	204457|Sphingomonadales	V	Transport permease protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane
HKD2_k127_359951_5	1449076.JOOE01000002_gene899	2.761e-86	298.0	COG0605@1|root,COG0605@2|Bacteria,1MVW2@1224|Proteobacteria,2TU3T@28211|Alphaproteobacteria,2K112@204457|Sphingomonadales	204457|Sphingomonadales	P	Destroys radicals which are normally produced within the cells and which are toxic to biological systems	-	-	1.15.1.1	ko:K04564	ko04013,ko04068,ko04146,ko04211,ko04212,ko04213,ko05016,map04013,map04068,map04146,map04211,map04212,map04213,map05016	-	-	-	ko00000,ko00001,ko01000	-	-	-	Sod_Fe_C,Sod_Fe_N
HKD2_k127_359951_6	1449076.JOOE01000002_gene900	2.978e-82	277.0	COG3748@1|root,COG3748@2|Bacteria,1RFIZ@1224|Proteobacteria,2U7B1@28211|Alphaproteobacteria,2K410@204457|Sphingomonadales	204457|Sphingomonadales	S	Urate oxidase N-terminal	-	-	-	-	-	-	-	-	-	-	-	-	Urate_ox_N
HKD2_k127_359951_0	1123267.JONN01000001_gene1115	1.56e-168	535.0	COG3829@1|root,COG3829@2|Bacteria,1QUPP@1224|Proteobacteria,2TR58@28211|Alphaproteobacteria,2K0CK@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain	pspF	-	-	ko:K03974	-	-	-	-	ko00000,ko03000	-	-	-	HTH_8,Sigma54_activat
HKD2_k127_359951_4	1123267.JONN01000001_gene1114	1.399e-92	309.0	COG1842@1|root,COG1842@2|Bacteria,1NC7S@1224|Proteobacteria,2U6CN@28211|Alphaproteobacteria,2K2DP@204457|Sphingomonadales	204457|Sphingomonadales	KT	Phage shock protein A	pspA	-	-	ko:K03969	-	-	-	-	ko00000	-	-	-	PspA_IM30
HKD2_k127_359951_10	1123267.JONN01000001_gene1113	1.607e-29	119.0	2EH78@1|root,33AZ2@2|Bacteria,1N7AP@1224|Proteobacteria,2UGJI@28211|Alphaproteobacteria,2K6SQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Phage shock protein B	pspB	-	-	ko:K03970	-	-	-	-	ko00000,ko02048	-	-	-	PspB
HKD2_k127_359951_9	1123267.JONN01000001_gene1112	1.745e-39	153.0	COG1983@1|root,COG1983@2|Bacteria,1RHXA@1224|Proteobacteria,2UA9Z@28211|Alphaproteobacteria,2K54F@204457|Sphingomonadales	204457|Sphingomonadales	KT	PspC domain	pspC	-	-	ko:K03973	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	PspC
HKD2_k127_359951_11	1248916.ANFY01000007_gene2370	1.554e-28	120.0	28X1J@1|root,344AU@2|Bacteria,1N404@1224|Proteobacteria,2UC94@28211|Alphaproteobacteria,2K65T@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_359951_14	1123267.JONN01000001_gene1111	4.302e-07	60.0	2B2V7@1|root,31VFS@2|Bacteria,1NBPZ@1224|Proteobacteria,2UGTR@28211|Alphaproteobacteria,2KCC5@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_359951_15	158500.BV97_05289	0.0006339	46.0	2ADWV@1|root,313NY@2|Bacteria,1N7F8@1224|Proteobacteria,2UF5X@28211|Alphaproteobacteria,2K6VX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_359951_8	1123267.JONN01000001_gene1109	6.365e-57	201.0	COG2166@1|root,COG2166@2|Bacteria,1RI8F@1224|Proteobacteria,2U9A2@28211|Alphaproteobacteria,2K4H9@204457|Sphingomonadales	204457|Sphingomonadales	S	SufE protein probably involved in Fe-S center assembly	sufE	-	-	ko:K02426	-	-	-	-	ko00000	-	-	-	SufE
HKD2_k127_359951_7	1123267.JONN01000001_gene1107	2.56e-79	271.0	COG2214@1|root,COG2214@2|Bacteria,1RHBK@1224|Proteobacteria,2TYF4@28211|Alphaproteobacteria,2KEMB@204457|Sphingomonadales	204457|Sphingomonadales	O	DnaJ molecular chaperone homology domain	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_359951_12	1150626.PHAMO_10077	4.369e-20	92.0	2DI18@1|root,301P8@2|Bacteria,1PTHJ@1224|Proteobacteria,2V5D3@28211|Alphaproteobacteria,2JYAW@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_359951_3	402626.Rpic_3439	1.106e-113	375.0	COG0657@1|root,COG0657@2|Bacteria,1N3TH@1224|Proteobacteria,2W12C@28216|Betaproteobacteria,1KCV0@119060|Burkholderiaceae	28216|Betaproteobacteria	I	Carboxylesterase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_3
HKD2_k127_3660866_7	1121106.JQKB01000017_gene4854	7.143e-09	62.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U9DR@28211|Alphaproteobacteria,2JSX3@204441|Rhodospirillales	204441|Rhodospirillales	C	COG3658 Cytochrome b	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_3660866_2	330214.NIDE3348	1.007e-95	327.0	COG2192@1|root,COG2192@2|Bacteria	2|Bacteria	O	nodulation	-	-	-	ko:K00612	-	-	-	-	ko00000,ko01000	-	-	-	Carbam_trans_C,Carbam_trans_N
HKD2_k127_3660866_1	1267005.KB911265_gene3640	6.179e-113	376.0	COG0577@1|root,COG0577@2|Bacteria,1MVSU@1224|Proteobacteria,2TUN8@28211|Alphaproteobacteria,3N7KA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_3660866_6	1120792.JAFV01000001_gene490	1.019e-13	79.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,36YWQ@31993|Methylocystaceae	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	GO:0003674,GO:0005215	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_3660866_5	744980.TRICHSKD4_5599	3.151e-14	74.0	COG1826@1|root,COG1826@2|Bacteria,1NGDP@1224|Proteobacteria,2UFBN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system	tatA	GO:0003674,GO:0005215	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_3660866_0	1116369.KB890024_gene3419	5.934e-167	529.0	COG1409@1|root,COG1409@2|Bacteria,1MUQJ@1224|Proteobacteria,2TTSK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_3660866_3	1131814.JAFO01000001_gene2160	1.799e-29	121.0	COG3794@1|root,COG3794@2|Bacteria,1RI9G@1224|Proteobacteria,2U7KA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Copper-bind,Cupredoxin_1
HKD2_k127_3660866_4	1510531.JQJJ01000012_gene1780	1.897e-17	86.0	COG1595@1|root,COG1595@2|Bacteria,1NRNT@1224|Proteobacteria,2TT5K@28211|Alphaproteobacteria,3JTET@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3835838_0	663610.JQKO01000011_gene3335	0.0	1655.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,3NCB7@45404|Beijerinckiaceae	28211|Alphaproteobacteria	V	Protein export membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_3835838_1	663610.JQKO01000011_gene3334	6.009e-66	227.0	COG0845@1|root,COG0845@2|Bacteria,1MXU4@1224|Proteobacteria,2TUXB@28211|Alphaproteobacteria,3NCCC@45404|Beijerinckiaceae	28211|Alphaproteobacteria	M	HlyD family secretion protein	-	-	-	-	-	-	-	-	-	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_3836428_2	392499.Swit_3384	1.409e-12	69.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales	204457|Sphingomonadales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_3836428_1	1335760.ASTG01000016_gene161	2.493e-44	166.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TT4I@28211|Alphaproteobacteria,2K354@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HKD2_k127_3836428_3	745310.G432_01955	3.456e-07	54.0	COG1028@1|root,COG1028@2|Bacteria,1MU3W@1224|Proteobacteria,2TT5X@28211|Alphaproteobacteria,2K05I@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Short-chain dehydrogenase reductase sdr	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_3836428_0	13689.BV96_03183	2.08e-322	1004.0	COG0574@1|root,COG1080@1|root,COG0574@2|Bacteria,COG1080@2|Bacteria,1MU0R@1224|Proteobacteria,2TR38@28211|Alphaproteobacteria,2K3HH@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers,PEP-utilizers_C,PPDK_N
HKD2_k127_3836428_4	1040987.AZUY01000046_gene4435	5.166e-06	48.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07483,ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,Tn7_Tnp_TnsA_N
HKD2_k127_3849855_27	314278.NB231_04130	1.45e-07	54.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,1S3JR@1236|Gammaproteobacteria	1236|Gammaproteobacteria	M	Nucleoside-diphosphate-sugar epimerase	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
HKD2_k127_3849855_2	1088721.NSU_0816	1.132e-223	710.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,2TSCY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_3849855_18	1082933.MEA186_03979	2.725e-41	165.0	COG0463@1|root,COG0463@2|Bacteria,1N8QE@1224|Proteobacteria,2UDFS@28211|Alphaproteobacteria,43HNH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	M	Glycosyltransferase like family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_3849855_17	570967.JMLV01000001_gene2799	1.601e-44	173.0	2DG8R@1|root,2ZUYV@2|Bacteria,1R8VA@1224|Proteobacteria,2VGKJ@28211|Alphaproteobacteria,2JZ9B@204441|Rhodospirillales	204441|Rhodospirillales	H	Sulfotransferase domain	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_1
HKD2_k127_3849855_20	204669.Acid345_3956	1.677e-29	128.0	COG2067@1|root,COG2067@2|Bacteria,3Y7IH@57723|Acidobacteria,2JMT6@204432|Acidobacteriia	204432|Acidobacteriia	I	long-chain fatty acid transport protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3849855_14	13690.CP98_01110	3.701e-55	204.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,2U8X3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3849855_15	1300345.LF41_2916	3.78e-54	200.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,1S5UD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3849855_10	1301098.PKB_3009	6.359e-70	249.0	COG2207@1|root,COG2207@2|Bacteria,1MX23@1224|Proteobacteria,1S1G1@1236|Gammaproteobacteria	1236|Gammaproteobacteria	K	AraC family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Arabinose_bd,HTH_18
HKD2_k127_3849855_13	1123267.JONN01000001_gene1703	2.079e-55	209.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria,2K90M@204457|Sphingomonadales	204457|Sphingomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_3849855_22	477228.YO5_07127	1.151e-22	108.0	COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,1T1XV@1236|Gammaproteobacteria,1Z2BR@136846|Pseudomonas stutzeri group	1236|Gammaproteobacteria	T	Cache 3/Cache 2 fusion domain	-	-	2.7.13.3	ko:K02480	-	-	-	-	ko00000,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA_3,sCache_2
HKD2_k127_3849855_9	13690.CP98_02888	3.601e-84	284.0	COG2197@1|root,COG2197@2|Bacteria,1R9GN@1224|Proteobacteria,2VETM@28211|Alphaproteobacteria,2KDUM@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,Response_reg
HKD2_k127_3849855_28	155864.EDL933_1377	6.997e-05	49.0	28N2S@1|root,2ZB8K@2|Bacteria,1R9VY@1224|Proteobacteria,1S6X2@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	P63C domain	-	-	-	-	-	-	-	-	-	-	-	-	P63C
HKD2_k127_3849855_21	861208.AGROH133_14527	5.433e-28	117.0	COG3620@1|root,COG3620@2|Bacteria,1N78J@1224|Proteobacteria,2UFE7@28211|Alphaproteobacteria,4BHHD@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_37
HKD2_k127_3849855_16	1267005.KB911256_gene1557	6.146e-52	185.0	COG4683@1|root,COG4683@2|Bacteria,1MZIY@1224|Proteobacteria,2UBSN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Phage derived protein Gp49-like (DUF891)	-	-	-	-	-	-	-	-	-	-	-	-	Gp49
HKD2_k127_3849855_7	1449076.JOOE01000003_gene3305	7.284e-108	354.0	COG0580@1|root,COG0580@2|Bacteria,1MXTJ@1224|Proteobacteria,2TRGG@28211|Alphaproteobacteria,2K1ZT@204457|Sphingomonadales	204457|Sphingomonadales	U	Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity	aqpZ	-	-	ko:K06188	-	-	-	-	ko00000,ko02000	1.A.8	-	-	MIP
HKD2_k127_3849855_12	1382356.JQMP01000001_gene1193	2.666e-65	255.0	COG0612@1|root,COG0612@2|Bacteria,2G5N3@200795|Chloroflexi,27XVK@189775|Thermomicrobia	189775|Thermomicrobia	S	Insulinase (Peptidase family M16)	-	-	-	ko:K07263	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_3849855_4	69279.BG36_05465	1.859e-183	583.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,43GR9@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	H	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_3
HKD2_k127_3849855_1	69279.BG36_05460	0.0	1008.0	COG0446@1|root,COG1902@1|root,COG0446@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TZTW@28211|Alphaproteobacteria,43MN8@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	NADH:flavin oxidoreductase / NADH oxidase family	-	-	1.5.8.1,1.5.8.2	ko:K00317	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R01588,R02511	RC00185,RC00556,RC00557,RC00732	ko00000,ko00001,ko01000	-	-	-	NAD_binding_8,Oxidored_FMN,Pyr_redox_2
HKD2_k127_3849855_8	204669.Acid345_3656	5.86e-104	353.0	COG3191@1|root,COG3191@2|Bacteria	2|Bacteria	EQ	aminopeptidase activity	dmpA	-	3.4.11.19	ko:K01266	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S58
HKD2_k127_3849855_3	69279.BG36_05495	7.588e-197	633.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2TUN4@28211|Alphaproteobacteria,43J21@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	C	Aldehyde dehydrogenase family	-	-	-	-	-	-	-	-	-	-	-	-	Aldedh
HKD2_k127_3849855_5	13690.CP98_05334	1.506e-117	385.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria,2K1VV@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	-	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_3849855_0	1163409.UUA_08346	0.0	1191.0	COG0823@1|root,COG0823@2|Bacteria,1MWYK@1224|Proteobacteria,1RXYW@1236|Gammaproteobacteria,1XD03@135614|Xanthomonadales	135614|Xanthomonadales	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_3849855_11	240015.ACP_3302	1e-68	248.0	COG2211@1|root,COG2211@2|Bacteria,3Y75A@57723|Acidobacteria,2JKQE@204432|Acidobacteriia	204432|Acidobacteriia	G	Major facilitator Superfamily	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	-
HKD2_k127_3849855_26	1112216.JH594425_gene421	4.521e-08	61.0	2EP5S@1|root,33GSG@2|Bacteria,1NI0K@1224|Proteobacteria,2UK2B@28211|Alphaproteobacteria,2K4PE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3849855_24	366602.Caul_0052	9.454e-11	68.0	2DPV3@1|root,333H6@2|Bacteria,1NPG6@1224|Proteobacteria,2UKUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3849855_25	517722.AEUE01000004_gene1130	2.756e-10	68.0	COG2771@1|root,COG2771@2|Bacteria,1NCXK@1224|Proteobacteria,2UHC8@28211|Alphaproteobacteria,2K7BM@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_7,GerE
HKD2_k127_3849855_19	555793.WSK_3272	1.874e-30	127.0	COG1595@1|root,COG1595@2|Bacteria,1NYUZ@1224|Proteobacteria,2UTB6@28211|Alphaproteobacteria,2K6CN@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_3849855_23	1219049.SP5_030_00330	5.714e-16	88.0	COG3712@1|root,COG3712@2|Bacteria,1MZCK@1224|Proteobacteria,2VEW2@28211|Alphaproteobacteria,2KDUB@204457|Sphingomonadales	204457|Sphingomonadales	PT	Domain of unknown function (DUF4880)	-	-	-	ko:K07165	-	-	-	-	ko00000	-	-	-	DUF4880,FecR
HKD2_k127_3849855_6	1331060.RLDS_06690	2.671e-117	407.0	COG1629@1|root,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTN6@28211|Alphaproteobacteria,2K1BR@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	ko:K02014	-	-	-	-	ko00000,ko02000	1.B.14	-	-	Plug,STN,TonB_dep_Rec
HKD2_k127_3853807_9	1123267.JONN01000002_gene146	1.29e-35	141.0	COG2919@1|root,COG2919@2|Bacteria,1NGSW@1224|Proteobacteria,2UJYE@28211|Alphaproteobacteria,2K7B8@204457|Sphingomonadales	204457|Sphingomonadales	D	Septum formation initiator	-	-	-	-	-	-	-	-	-	-	-	-	DivIC
HKD2_k127_3853807_3	1123267.JONN01000002_gene145	5.572e-217	682.0	COG0148@1|root,COG0148@2|Bacteria,1MU1N@1224|Proteobacteria,2TR04@28211|Alphaproteobacteria,2K00W@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis	eno	-	4.2.1.11	ko:K01689	ko00010,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko03018,ko04066,map00010,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map03018,map04066	M00001,M00002,M00003,M00346,M00394	R00658	RC00349	ko00000,ko00001,ko00002,ko01000,ko03019,ko04147	-	-	-	Enolase_C,Enolase_N
HKD2_k127_3853807_10	1123267.JONN01000002_gene144	2.601e-29	125.0	2EJM3@1|root,33DC0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3853807_16	1449076.JOOE01000001_gene1734	4.771e-11	70.0	2BJES@1|root,32DR8@2|Bacteria,1Q84X@1224|Proteobacteria,2VEAR@28211|Alphaproteobacteria,2K7D2@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative Actinobacterial Holin-X, holin superfamily III	-	-	-	-	-	-	-	-	-	-	-	-	Phage_holin_3_6
HKD2_k127_3853807_17	745310.G432_13070	1.21e-08	64.0	2APHC@1|root,31EKB@2|Bacteria,1QBWH@1224|Proteobacteria,2VEF2@28211|Alphaproteobacteria,2K7RB@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3618)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3618
HKD2_k127_3853807_15	1112212.JH584235_gene3679	9.37e-13	73.0	28M97@1|root,2ZAN6@2|Bacteria,1P8DS@1224|Proteobacteria,2UXPS@28211|Alphaproteobacteria,2K5VF@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3853807_11	1123269.NX02_00270	6.466e-29	117.0	COG0483@1|root,COG0483@2|Bacteria,1N7D7@1224|Proteobacteria,2UF6T@28211|Alphaproteobacteria,2K5WG@204457|Sphingomonadales	204457|Sphingomonadales	G	Domain of unknown function (DUF4170)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4170
HKD2_k127_3853807_6	1123267.JONN01000002_gene138	8.122e-67	236.0	COG0705@1|root,COG0705@2|Bacteria,1MYFP@1224|Proteobacteria,2TSJG@28211|Alphaproteobacteria,2K57C@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane protein (homolog of Drosophila rhomboid)	-	-	-	-	-	-	-	-	-	-	-	-	Rhomboid
HKD2_k127_3853807_5	1123267.JONN01000002_gene137	4.427e-73	250.0	COG0782@1|root,COG0782@2|Bacteria,1RCXW@1224|Proteobacteria,2U5JU@28211|Alphaproteobacteria,2K439@204457|Sphingomonadales	204457|Sphingomonadales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides	greA	-	-	ko:K03624	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_3853807_0	1123267.JONN01000002_gene136	0.0	1817.0	COG0458@1|root,COG0458@2|Bacteria,1MUDZ@1224|Proteobacteria,2TQZU@28211|Alphaproteobacteria,2JZX4@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the CarB family	carB	-	6.3.5.5	ko:K01955	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_L_D2,CPSase_L_D3,MGS
HKD2_k127_3853807_4	1123267.JONN01000002_gene135	2.591e-200	630.0	COG0505@1|root,COG0505@2|Bacteria,1MUB9@1224|Proteobacteria,2TR3W@28211|Alphaproteobacteria,2K02X@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the CarA family	carA	-	6.3.5.5	ko:K01956	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R00256,R00575,R01395,R10948,R10949	RC00002,RC00010,RC00043,RC02750,RC02798,RC03314	ko00000,ko00001,ko00002,ko01000	-	-	-	CPSase_sm_chain,GATase
HKD2_k127_3853807_7	1123267.JONN01000002_gene134	2.307e-61	214.0	COG1610@1|root,COG1610@2|Bacteria,1RGZS@1224|Proteobacteria,2U7DJ@28211|Alphaproteobacteria,2K3W5@204457|Sphingomonadales	204457|Sphingomonadales	S	Yqey-like protein	-	-	-	ko:K09117	-	-	-	-	ko00000	-	-	-	YqeY
HKD2_k127_3853807_2	1123267.JONN01000002_gene132	2.578e-218	701.0	COG0358@1|root,COG0358@2|Bacteria,1MUHC@1224|Proteobacteria,2TRU2@28211|Alphaproteobacteria,2K0VR@204457|Sphingomonadales	204457|Sphingomonadales	L	RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication	dnaG	-	-	ko:K02316	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	Toprim_4,Toprim_N,zf-CHC2
HKD2_k127_3853807_1	1248917.ANFX01000008_gene342	8.921e-304	944.0	COG0568@1|root,COG0568@2|Bacteria,1MVNJ@1224|Proteobacteria,2TS6C@28211|Alphaproteobacteria,2K260@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth	rpoD	-	-	ko:K03086	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_ner,Sigma70_r1_1,Sigma70_r1_2,Sigma70_r2,Sigma70_r3,Sigma70_r4
HKD2_k127_3853807_13	279238.Saro_2222	4.579e-17	88.0	COG1846@1|root,COG1846@2|Bacteria,1NYW3@1224|Proteobacteria,2UTVX@28211|Alphaproteobacteria,2K6HH@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
HKD2_k127_3853807_14	1088721.NSU_0025	2.752e-16	85.0	COG1846@1|root,COG1846@2|Bacteria,1NYW3@1224|Proteobacteria,2UTVX@28211|Alphaproteobacteria,2K6HH@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
HKD2_k127_3853807_8	1331060.RLDS_00435	2.284e-44	164.0	2E9ZW@1|root,33G1Y@2|Bacteria,1NHJW@1224|Proteobacteria,2V9KJ@28211|Alphaproteobacteria,2K5D6@204457|Sphingomonadales	204457|Sphingomonadales	S	SpoIIAA-like	-	-	-	-	-	-	-	-	-	-	-	-	SpoIIAA-like
HKD2_k127_3853807_12	1112214.AHIS01000093_gene527	1.61e-25	115.0	2ARC9@1|root,31GNA@2|Bacteria,1N6EK@1224|Proteobacteria,2UCRU@28211|Alphaproteobacteria,2K627@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3853807_18	1282362.AEAC466_05545	2.55e-08	57.0	2BTYK@1|root,32P72@2|Bacteria,1Q8R0@1224|Proteobacteria,2UXQW@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3854826_3	317655.Sala_0010	1.244e-20	98.0	2E32R@1|root,32Y2Y@2|Bacteria,1N91I@1224|Proteobacteria,2UI6P@28211|Alphaproteobacteria,2K701@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3854826_1	1449076.JOOE01000003_gene3574	9.931e-68	242.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2U0M2@28211|Alphaproteobacteria,2K2B0@204457|Sphingomonadales	204457|Sphingomonadales	KT	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HKD2_k127_3854826_2	1449076.JOOE01000003_gene3575	2.89e-67	242.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria,2K0W4@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HKD2_k127_3854826_0	1123267.JONN01000001_gene1985	5.97e-97	327.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_3923161_1	1123267.JONN01000002_gene242	9.904e-290	903.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,2K1XU@204457|Sphingomonadales	204457|Sphingomonadales	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD2_k127_3923161_15	1114964.L485_16605	1.819e-101	346.0	COG2244@1|root,COG2244@2|Bacteria,1RDQG@1224|Proteobacteria,2U27A@28211|Alphaproteobacteria,2K2K5@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt_3
HKD2_k127_3923161_13	342113.DM82_1875	1.001e-131	424.0	COG2877@1|root,COG2877@2|Bacteria,1MV91@1224|Proteobacteria,2VIQF@28216|Betaproteobacteria,1JZYF@119060|Burkholderiaceae	28216|Betaproteobacteria	M	3-deoxy-D-manno-octulosonic acid 8-phosphate synthase	kdsA	-	2.5.1.55	ko:K01627	ko00540,ko01100,map00540,map01100	M00063	R03254	RC00435	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	DAHP_synth_1
HKD2_k127_3923161_21	1123267.JONN01000002_gene240	1.699e-74	259.0	COG0647@1|root,COG0647@2|Bacteria,1MU9Y@1224|Proteobacteria,2TUH0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	sugar phosphatases of the HAD superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_6,Hydrolase_like
HKD2_k127_3923161_20	745310.G432_11010	5.431e-78	273.0	COG1212@1|root,COG1212@2|Bacteria,1MUUU@1224|Proteobacteria,2TUQM@28211|Alphaproteobacteria,2K293@204457|Sphingomonadales	204457|Sphingomonadales	M	3-deoxy-manno-octulosonate cytidylyltransferase	-	-	2.7.7.38	ko:K00979	ko00540,ko01100,map00540,map01100	M00063	R03351,R11396	RC00152,RC00910	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CTP_transf_3
HKD2_k127_3923161_19	1461693.ATO10_05946	8.954e-89	302.0	COG0517@1|root,COG0794@1|root,COG0517@2|Bacteria,COG0794@2|Bacteria,1MUXD@1224|Proteobacteria,2TU5X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Belongs to the SIS family. GutQ KpsF subfamily	kdsD	-	5.3.1.13	ko:K06041	ko00540,ko01100,map00540,map01100	M00063	R01530	RC00541	ko00000,ko00001,ko00002,ko01000,ko01005	-	-	-	CBS,SIS
HKD2_k127_3923161_4	1123269.NX02_14195	2.703e-197	623.0	COG1301@1|root,COG1301@2|Bacteria,1MU0Q@1224|Proteobacteria,2TUFB@28211|Alphaproteobacteria,2K0FM@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_3923161_9	392499.Swit_4409	5.763e-155	500.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TRQ5@28211|Alphaproteobacteria,2K0GN@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the peptidase M24B family	-	-	3.4.13.9	ko:K01271	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Peptidase_M24
HKD2_k127_3923161_18	1123240.ATVO01000006_gene1390	1.253e-94	323.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TR41@28211|Alphaproteobacteria,2K6YP@204457|Sphingomonadales	204457|Sphingomonadales	E	Arginase family	-	-	-	-	-	-	-	-	-	-	-	-	Arginase
HKD2_k127_3923161_12	1123267.JONN01000002_gene239	2.833e-144	469.0	COG0477@1|root,COG2814@2|Bacteria,1MW19@1224|Proteobacteria,2TRJ1@28211|Alphaproteobacteria,2K0JH@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	ko:K07552	-	-	-	-	ko00000,ko02000	2.A.1.2	-	-	MFS_1
HKD2_k127_3923161_5	745310.G432_18050	4.698e-197	618.0	COG0468@1|root,COG0468@2|Bacteria,1MU3C@1224|Proteobacteria,2TRPR@28211|Alphaproteobacteria,2K1TR@204457|Sphingomonadales	204457|Sphingomonadales	L	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage	recA	-	-	ko:K03553	ko03440,map03440	M00729	-	-	ko00000,ko00001,ko00002,ko03400	-	-	-	RecA
HKD2_k127_3923161_16	392499.Swit_4601	1.901e-99	335.0	COG1266@1|root,COG1266@2|Bacteria,1RCTR@1224|Proteobacteria,2VGN5@28211|Alphaproteobacteria,2KE4U@204457|Sphingomonadales	204457|Sphingomonadales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_3923161_8	685778.AORL01000001_gene135	1.676e-172	552.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U0BD@28211|Alphaproteobacteria,2KCU9@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_3923161_2	1346791.M529_06940	2.711e-282	902.0	COG0457@1|root,COG1305@1|root,COG0457@2|Bacteria,COG1305@2|Bacteria,1R5Q7@1224|Proteobacteria,2U24E@28211|Alphaproteobacteria,2K21Z@204457|Sphingomonadales	204457|Sphingomonadales	E	Domain of Unknown Function with PDB structure (DUF3857)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3857,TPR_16,TPR_8,Transglut_core
HKD2_k127_3923161_14	1123267.JONN01000002_gene353	4.22e-114	371.0	COG0740@1|root,COG0740@2|Bacteria,1MV46@1224|Proteobacteria,2TR5M@28211|Alphaproteobacteria,2JZX6@204457|Sphingomonadales	204457|Sphingomonadales	OU	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins	clpP	-	3.4.21.92	ko:K01358	ko04112,ko04212,map04112,map04212	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	CLP_protease
HKD2_k127_3923161_0	1502850.FG91_03844	0.0	1041.0	COG4206@1|root,COG4206@2|Bacteria,1R47X@1224|Proteobacteria,2TW6Q@28211|Alphaproteobacteria,2K1IJ@204457|Sphingomonadales	204457|Sphingomonadales	H	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_3923161_10	1123267.JONN01000002_gene349	5.731e-152	484.0	COG1215@1|root,COG1215@2|Bacteria,1QU2F@1224|Proteobacteria,2U0P8@28211|Alphaproteobacteria,2K007@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_3923161_24	1380394.JADL01000001_gene2668	1.061e-58	216.0	COG0662@1|root,COG0662@2|Bacteria,1NX8W@1224|Proteobacteria,2TY4P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_3923161_7	1030157.AFMP01000008_gene3206	7.03e-181	581.0	COG0544@1|root,COG0544@2|Bacteria,1MUJP@1224|Proteobacteria,2TS8W@28211|Alphaproteobacteria,2K02U@204457|Sphingomonadales	204457|Sphingomonadales	D	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase	tig	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	-	ko:K03545	-	-	-	-	ko00000	-	-	-	FKBP_C,Trigger_C,Trigger_N
HKD2_k127_3923161_26	1120963.KB894491_gene1107	2.157e-07	64.0	2DE24@1|root,2ZK69@2|Bacteria,1P9N5@1224|Proteobacteria,1SU0Y@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3923161_22	1123267.JONN01000002_gene346	5.723e-72	249.0	2EAQM@1|root,334SV@2|Bacteria,1N39W@1224|Proteobacteria,2UE2Z@28211|Alphaproteobacteria,2K4QC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3923161_11	1123267.JONN01000002_gene345	6.979e-147	477.0	COG4783@1|root,COG4783@2|Bacteria,1RAJB@1224|Proteobacteria,2TRY3@28211|Alphaproteobacteria,2JZYT@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48
HKD2_k127_3923161_17	1123267.JONN01000002_gene344	8.293e-96	321.0	2EDW0@1|root,32VXH@2|Bacteria,1R3JT@1224|Proteobacteria,2U03S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3923161_6	1123267.JONN01000002_gene127	7.36e-186	597.0	COG1524@1|root,COG1524@2|Bacteria,1R5V5@1224|Proteobacteria,2U4ZG@28211|Alphaproteobacteria,2K230@204457|Sphingomonadales	204457|Sphingomonadales	S	Alkaline phosphatase with broad substrate specificity	-	-	3.1.3.1	ko:K01077	ko00730,ko00790,ko01100,ko02020,map00730,map00790,map01100,map02020	M00126	R02135,R04620	RC00017	ko00000,ko00001,ko00002,ko00537,ko01000,ko04147	-	-	-	Phosphodiest
HKD2_k127_3923161_3	1123267.JONN01000002_gene126	2.613e-268	831.0	COG0064@1|root,COG0064@2|Bacteria,1MUKG@1224|Proteobacteria,2TRHX@28211|Alphaproteobacteria,2K04H@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatB	-	6.3.5.6,6.3.5.7	ko:K02434	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	GatB_N,GatB_Yqey
HKD2_k127_3923161_23	1123267.JONN01000002_gene125	4.482e-71	241.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,2K0UD@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_3966018_2	1569209.BBPH01000094_gene1380	0.0004867	48.0	COG1396@1|root,COG1396@2|Bacteria,1RK54@1224|Proteobacteria	1224|Proteobacteria	K	TRANSCRIPTIONal	-	-	-	-	-	-	-	-	-	-	-	-	HTH_19,HTH_3
HKD2_k127_3980105_12	1112212.JH584236_gene27	5.293e-11	64.0	COG1295@1|root,COG1633@1|root,COG1295@2|Bacteria,COG1633@2|Bacteria,1MXQA@1224|Proteobacteria,2TSFP@28211|Alphaproteobacteria,2K0P0@204457|Sphingomonadales	204457|Sphingomonadales	S	Virulence factor BrkB	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	HAD_2,Virul_fac_BrkB
HKD2_k127_3980105_1	1123267.JONN01000001_gene1971	6.692e-186	597.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_3980105_8	1122604.JONR01000002_gene1619	2.288e-55	207.0	2919Q@1|root,32TZW@2|Bacteria,1Q71M@1224|Proteobacteria,1SIND@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3980105_6	392499.Swit_4519	1.044e-68	242.0	COG4798@1|root,COG4798@2|Bacteria,1RHGZ@1224|Proteobacteria,2U69N@28211|Alphaproteobacteria,2KDKH@204457|Sphingomonadales	204457|Sphingomonadales	S	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,PCMT
HKD2_k127_3980105_4	1123267.JONN01000001_gene575	7.171e-100	341.0	COG1301@1|root,COG1301@2|Bacteria,1MVID@1224|Proteobacteria,2TUR0@28211|Alphaproteobacteria,2K09V@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the dicarboxylate amino acid cation symporter (DAACS) (TC 2.A.23) family	-	-	-	-	-	-	-	-	-	-	-	-	SDF
HKD2_k127_3980105_3	1123267.JONN01000001_gene576	1.067e-110	362.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria,2KD3G@204457|Sphingomonadales	204457|Sphingomonadales	T	LytTr DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HKD2_k127_3980105_2	1123267.JONN01000001_gene577	4.065e-133	437.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria,2K0W4@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HKD2_k127_3980105_5	1123267.JONN01000001_gene579	9.878e-99	324.0	2AFT8@1|root,315VF@2|Bacteria,1RAPJ@1224|Proteobacteria,2U6M6@28211|Alphaproteobacteria,2K2CZ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3980105_10	935863.AWZR01000001_gene1662	1.625e-28	123.0	2EKD9@1|root,33E3J@2|Bacteria,1RIMW@1224|Proteobacteria,1S7IQ@1236|Gammaproteobacteria,1XB6N@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3980105_7	1123267.JONN01000001_gene580	3.683e-64	228.0	2D94Q@1|root,32TSM@2|Bacteria,1R37H@1224|Proteobacteria,2TZZ1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	NT5C
HKD2_k127_3980105_9	1096930.L284_20950	5.31e-41	155.0	2C3SB@1|root,33M42@2|Bacteria,1N468@1224|Proteobacteria,2UC0I@28211|Alphaproteobacteria,2K717@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_3980105_0	1123267.JONN01000001_gene582	4.127e-193	616.0	COG0773@1|root,COG0773@2|Bacteria,1MVCG@1224|Proteobacteria,2TTDN@28211|Alphaproteobacteria,2K0S4@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-N-acetylmuramate-alanine ligase	-	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_4022539_2	1123267.JONN01000001_gene1278	2.496e-57	203.0	COG3667@1|root,COG3667@2|Bacteria,1R6TA@1224|Proteobacteria,2U52R@28211|Alphaproteobacteria,2K3M1@204457|Sphingomonadales	204457|Sphingomonadales	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4022539_0	391619.PGA1_c19280	1.278e-147	481.0	COG2253@1|root,COG2253@2|Bacteria,1PZRM@1224|Proteobacteria,2TTHC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD2_k127_4022539_1	1114964.L485_02515	5.633e-75	258.0	COG5340@1|root,COG5340@2|Bacteria,1R1GM@1224|Proteobacteria,2TTDH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4022539_3	381666.H16_B0937	1.553e-08	57.0	COG2207@1|root,COG2207@2|Bacteria,1N0FA@1224|Proteobacteria,2VKR0@28216|Betaproteobacteria,1K2I8@119060|Burkholderiaceae	28216|Betaproteobacteria	K	Cupin	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_6,HTH_18
HKD2_k127_4132778_10	1248917.ANFX01000031_gene2557	9.516e-08	54.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2URCQ@28211|Alphaproteobacteria,2K511@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	UPF0227
HKD2_k127_4132778_5	1337093.MBE-LCI_1179	1.824e-49	184.0	COG4544@1|root,COG4544@2|Bacteria,1MY56@1224|Proteobacteria,2TT91@28211|Alphaproteobacteria,2P9WK@245186|Loktanella	28211|Alphaproteobacteria	S	SOS response	-	-	-	ko:K14160	-	-	-	-	ko00000,ko03400	-	-	-	-
HKD2_k127_4132778_3	1123267.JONN01000001_gene2313	5.306e-162	526.0	COG0389@1|root,COG0389@2|Bacteria,1MU5X@1224|Proteobacteria,2TQVR@28211|Alphaproteobacteria,2JZYV@204457|Sphingomonadales	204457|Sphingomonadales	L	Nucleotidyltransferase DNA polymerase involved in DNA repair	-	-	-	ko:K14161	-	-	-	-	ko00000,ko03400	-	-	-	IMS
HKD2_k127_4132778_0	1123267.JONN01000001_gene2314	0.0	1590.0	COG0587@1|root,COG0587@2|Bacteria,1MUE4@1224|Proteobacteria,2TRUB@28211|Alphaproteobacteria,2JZWI@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase	dnaE2	-	2.7.7.7	ko:K14162	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP,tRNA_anti-codon
HKD2_k127_4132778_7	69395.JQLZ01000007_gene1600	1.657e-22	102.0	COG4731@1|root,COG4731@2|Bacteria,1PZC6@1224|Proteobacteria,2VAFN@28211|Alphaproteobacteria,2KIX5@204458|Caulobacterales	204458|Caulobacterales	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD2_k127_4132778_9	69395.JQLZ01000007_gene1600	8.656e-20	98.0	COG4731@1|root,COG4731@2|Bacteria,1PZC6@1224|Proteobacteria,2VAFN@28211|Alphaproteobacteria,2KIX5@204458|Caulobacterales	204458|Caulobacterales	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD2_k127_4132778_8	158500.BV97_01689	1.492e-21	98.0	COG4731@1|root,COG4731@2|Bacteria,1RHN9@1224|Proteobacteria,2UEIJ@28211|Alphaproteobacteria,2K69D@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD2_k127_4132778_6	1123267.JONN01000001_gene2315	6.173e-26	111.0	COG4731@1|root,COG4731@2|Bacteria,1RHN9@1224|Proteobacteria,2UEIJ@28211|Alphaproteobacteria,2K69D@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2147)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2147
HKD2_k127_4132778_2	1123267.JONN01000001_gene2292	4.766e-225	706.0	COG2986@1|root,COG2986@2|Bacteria,1MU6K@1224|Proteobacteria,2TSPJ@28211|Alphaproteobacteria,2K1IZ@204457|Sphingomonadales	204457|Sphingomonadales	E	Histidine	hutH	-	4.3.1.3	ko:K01745	ko00340,ko01100,map00340,map01100	M00045	R01168	RC00361	ko00000,ko00001,ko00002,ko01000	-	-	-	Lyase_aromatic
HKD2_k127_4132778_4	1088721.NSU_2734	3.655e-54	209.0	COG2199@1|root,COG2199@2|Bacteria,1R49V@1224|Proteobacteria,2TTDC@28211|Alphaproteobacteria,2K4KD@204457|Sphingomonadales	204457|Sphingomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_4132778_1	1123267.JONN01000001_gene2288	0.0	997.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,2K2BT@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_4354675_36	392499.Swit_1360	2.446e-92	312.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria,2JZZM@204457|Sphingomonadales	204457|Sphingomonadales	P	cation diffusion facilitator	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_4354675_13	1346791.M529_06020	5.399e-193	610.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_4354675_6	1537715.JQFJ01000002_gene719	8.592e-237	739.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TR8H@28211|Alphaproteobacteria,2JZWH@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_4354675_48	1248917.ANFX01000008_gene238	1.143e-38	148.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,2K5WB@204457|Sphingomonadales	204457|Sphingomonadales	I	Thioesterase superfamily	-	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD2_k127_4354675_14	1114964.L485_20950	1.486e-181	579.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TRXM@28211|Alphaproteobacteria,2K0EK@204457|Sphingomonadales	204457|Sphingomonadales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhC	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_4354675_44	1030157.AFMP01000035_gene3312	1.135e-51	186.0	COG0589@1|root,COG0589@2|Bacteria,1R9XB@1224|Proteobacteria,2U59E@28211|Alphaproteobacteria,2K49I@204457|Sphingomonadales	204457|Sphingomonadales	T	Universal stress protein	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_4354675_39	1123267.JONN01000001_gene1576	1.236e-70	243.0	COG1956@1|root,COG1956@2|Bacteria,1RDBM@1224|Proteobacteria,2U595@28211|Alphaproteobacteria,2K4NG@204457|Sphingomonadales	204457|Sphingomonadales	T	GAF domain-containing protein	-	-	1.8.4.14	ko:K08968	ko00270,map00270	-	R02025	RC00639	ko00000,ko00001,ko01000	-	-	-	GAF_2
HKD2_k127_4354675_47	629773.AORY01000004_gene500	2.842e-42	159.0	COG1186@1|root,COG1186@2|Bacteria,1RH75@1224|Proteobacteria,2U9M7@28211|Alphaproteobacteria,2K5BU@204457|Sphingomonadales	204457|Sphingomonadales	J	chain release factor	-	-	-	ko:K15034	-	-	-	-	ko00000,ko03012	-	-	-	RF-1
HKD2_k127_4354675_35	1123267.JONN01000001_gene1661	6.651e-95	315.0	COG0564@1|root,COG0564@2|Bacteria,1MVJ5@1224|Proteobacteria,2TSCG@28211|Alphaproteobacteria,2K0XZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Pseudouridine synthase	-	-	5.4.99.28,5.4.99.29	ko:K06177	-	-	-	-	ko00000,ko01000,ko03009,ko03016	-	-	-	PseudoU_synth_2
HKD2_k127_4354675_25	1123267.JONN01000001_gene1662	6.816e-143	456.0	COG0745@1|root,COG0745@2|Bacteria,1MWVI@1224|Proteobacteria,2TRSP@28211|Alphaproteobacteria,2K0S8@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	ctrA	-	-	ko:K13584	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_4354675_29	452662.SJA_C1-15210	1.117e-128	415.0	COG2935@1|root,COG2935@2|Bacteria,1MW62@1224|Proteobacteria,2TQY8@28211|Alphaproteobacteria,2K00M@204457|Sphingomonadales	204457|Sphingomonadales	O	May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate	ate	-	2.3.2.29	ko:K21420	-	-	R11547,R11548	RC00064	ko00000,ko01000	-	-	-	ATE_C,ATE_N
HKD2_k127_4354675_16	1123267.JONN01000001_gene481	6.212e-176	560.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K130@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine dehydratase	ilvA	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	ACT,PALP
HKD2_k127_4354675_11	745310.G432_16060	1.678e-193	617.0	COG1574@1|root,COG1574@2|Bacteria,1MWP2@1224|Proteobacteria,2TTRU@28211|Alphaproteobacteria,2K1UV@204457|Sphingomonadales	204457|Sphingomonadales	S	Metal-dependent hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_4354675_7	1123267.JONN01000001_gene479	9.413e-228	722.0	COG4232@1|root,COG4233@1|root,COG4232@2|Bacteria,COG4233@2|Bacteria,1MU8W@1224|Proteobacteria,2TTUM@28211|Alphaproteobacteria,2K11D@204457|Sphingomonadales	204457|Sphingomonadales	CO	Thiol disulfide interchange protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbC,DsbD,Thioredoxin_7
HKD2_k127_4354675_1	1123267.JONN01000001_gene478	0.0	1337.0	COG1410@1|root,COG1410@2|Bacteria,1MV6G@1224|Proteobacteria,2TQTG@28211|Alphaproteobacteria,2K0JK@204457|Sphingomonadales	204457|Sphingomonadales	E	5-methyltetrahydrofolate--homocysteine methyltransferase	metH	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,B12-binding_2,Met_synt_B12,Pterin_bind
HKD2_k127_4354675_23	1081640.AGFU01000018_gene1773	2.465e-147	481.0	COG0646@1|root,COG0646@2|Bacteria,1NPFY@1224|Proteobacteria,2UJRS@28211|Alphaproteobacteria,2K10F@204457|Sphingomonadales	204457|Sphingomonadales	E	Methionine synthase I (cobalamin-dependent), methyltransferase domain	-	-	2.1.1.13	ko:K00548	ko00270,ko00450,ko00670,ko01100,ko01110,ko01230,map00270,map00450,map00670,map01100,map01110,map01230	M00017	R00946,R09365	RC00035,RC00113,RC01241	ko00000,ko00001,ko00002,ko01000	-	-	-	S-methyl_trans
HKD2_k127_4354675_22	1123267.JONN01000001_gene476	1.034e-147	474.0	COG0685@1|root,COG0685@2|Bacteria,1MUC9@1224|Proteobacteria,2TQZA@28211|Alphaproteobacteria,2K03Q@204457|Sphingomonadales	204457|Sphingomonadales	E	Methylenetetrahydrofolate reductase	metF	-	1.5.1.20	ko:K00297	ko00670,ko00720,ko01100,ko01120,ko01200,ko01523,map00670,map00720,map01100,map01120,map01200,map01523	M00377	R01224,R07168	RC00081	ko00000,ko00001,ko00002,ko01000	-	-	-	MTHFR
HKD2_k127_4354675_32	745310.G432_16545	7.659e-120	392.0	COG0500@1|root,COG0640@1|root,COG0640@2|Bacteria,COG2226@2|Bacteria,1NFSV@1224|Proteobacteria,2TSMV@28211|Alphaproteobacteria,2K0VB@204457|Sphingomonadales	204457|Sphingomonadales	K	ArsR family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_20,HTH_5,Methyltransf_11
HKD2_k127_4354675_3	1123267.JONN01000001_gene471	9.281e-311	957.0	COG0459@1|root,COG0459@2|Bacteria,1MURR@1224|Proteobacteria,2TS07@28211|Alphaproteobacteria,2K0H3@204457|Sphingomonadales	204457|Sphingomonadales	O	Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions	groL	-	-	ko:K04077	ko03018,ko04212,ko04940,ko05134,ko05152,map03018,map04212,map04940,map05134,map05152	-	-	-	ko00000,ko00001,ko03019,ko03029,ko03110,ko04147	-	-	-	Cpn60_TCP1
HKD2_k127_4354675_46	1449076.JOOE01000003_gene3194	4.414e-50	179.0	COG0234@1|root,COG0234@2|Bacteria,1MZ2X@1224|Proteobacteria,2U9AQ@28211|Alphaproteobacteria,2K539@204457|Sphingomonadales	204457|Sphingomonadales	O	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter	groS	-	-	ko:K04078	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Cpn10
HKD2_k127_4354675_24	745310.G432_09425	1.65e-143	470.0	COG0534@1|root,COG0534@2|Bacteria,1MUAM@1224|Proteobacteria,2TSDU@28211|Alphaproteobacteria,2K152@204457|Sphingomonadales	204457|Sphingomonadales	V	Na -driven multidrug efflux pump	-	-	-	ko:K03327	-	-	-	-	ko00000,ko02000	2.A.66.1	-	-	MatE
HKD2_k127_4354675_10	1123267.JONN01000001_gene462	1.513e-212	676.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,2K1TY@204457|Sphingomonadales	204457|Sphingomonadales	OU	signal peptide peptidase	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_4354675_45	1280949.HAD_01095	2.249e-50	188.0	COG1247@1|root,COG1247@2|Bacteria,1RGU8@1224|Proteobacteria,2UAVJ@28211|Alphaproteobacteria,4411I@69657|Hyphomonadaceae	28211|Alphaproteobacteria	M	COG1247 Sortase and related acyltransferases	-	-	2.3.1.183	ko:K03823	ko00440,ko01130,map00440,map01130	-	R08871,R08938	RC00004,RC00064	ko00000,ko00001,ko01000	-	-	-	Acetyltransf_4
HKD2_k127_4354675_5	745310.G432_03945	4.082e-244	759.0	COG1249@1|root,COG1249@2|Bacteria,1MU2U@1224|Proteobacteria,2TRN7@28211|Alphaproteobacteria,2K1EA@204457|Sphingomonadales	204457|Sphingomonadales	C	COG1249 Pyruvate 2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes	-	-	1.8.1.4	ko:K00382	ko00010,ko00020,ko00260,ko00280,ko00620,ko00630,ko00640,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00260,map00280,map00620,map00630,map00640,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00036,M00307,M00532	R00209,R01221,R01698,R03815,R07618,R08549	RC00004,RC00022,RC00583,RC02742,RC02833,RC02834	br01601,ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_4354675_15	745310.G432_03950	1.288e-178	569.0	COG0508@1|root,COG0508@2|Bacteria,1MUJD@1224|Proteobacteria,2TS5N@28211|Alphaproteobacteria,2K18R@204457|Sphingomonadales	204457|Sphingomonadales	C	The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2)	sucB	-	2.3.1.61	ko:K00658	ko00020,ko00310,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R02570,R02571,R08549	RC00004,RC02727,RC02833	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_4354675_0	1123267.JONN01000001_gene1672	0.0	1528.0	COG0567@1|root,COG0567@2|Bacteria,1MVBF@1224|Proteobacteria,2TRBQ@28211|Alphaproteobacteria,2K1J3@204457|Sphingomonadales	204457|Sphingomonadales	C	E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate	sucA	-	1.2.4.2	ko:K00164	ko00020,ko00310,ko00380,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00310,map00380,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00032	R00621,R01933,R01940,R03316,R08549	RC00004,RC00027,RC00627,RC02743,RC02833,RC02883	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxogl_dehyd_N,E1_dh,OxoGdeHyase_C,Transket_pyr
HKD2_k127_4354675_20	1123267.JONN01000001_gene1673	1.289e-163	518.0	COG0074@1|root,COG0074@2|Bacteria,1MUGA@1224|Proteobacteria,2TQKB@28211|Alphaproteobacteria,2K1F5@204457|Sphingomonadales	204457|Sphingomonadales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit	sucD	-	6.2.1.5	ko:K01902	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	CoA_binding,Ligase_CoA
HKD2_k127_4354675_17	1081640.AGFU01000020_gene1886	1.135e-173	549.0	COG0039@1|root,COG0039@2|Bacteria,1MV57@1224|Proteobacteria,2TSV6@28211|Alphaproteobacteria,2K17I@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the reversible oxidation of malate to oxaloacetate	mdh	-	1.1.1.37	ko:K00024	ko00020,ko00270,ko00620,ko00630,ko00680,ko00710,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00270,map00620,map00630,map00680,map00710,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00012,M00168,M00173,M00346,M00374,M00620,M00740	R00342,R07136	RC00031	ko00000,ko00001,ko00002,ko01000	-	-	-	Ldh_1_C,Ldh_1_N
HKD2_k127_4354675_28	1122137.AQXF01000007_gene3524	2.114e-130	419.0	COG0479@1|root,COG0479@2|Bacteria,1MVHS@1224|Proteobacteria,2TQYF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family	sdhB	-	1.3.5.1,1.3.5.4	ko:K00240	ko00020,ko00190,ko00650,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00190,map00650,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00149,M00173,M00374,M00376	R02164	RC00045	ko00000,ko00001,ko00002,ko01000	-	-	-	Fer2_3,Fer4_10,Fer4_17,Fer4_8
HKD2_k127_4354675_41	1123267.JONN01000001_gene1682	9.617e-66	228.0	COG2050@1|root,COG2050@2|Bacteria,1MZPH@1224|Proteobacteria,2UDIQ@28211|Alphaproteobacteria,2K62E@204457|Sphingomonadales	204457|Sphingomonadales	Q	protein, possibly involved in aromatic compounds catabolism	-	-	-	-	-	-	-	-	-	-	-	-	4HBT
HKD2_k127_4354675_19	1123267.JONN01000001_gene1681	4.163e-164	524.0	COG1485@1|root,COG1485@2|Bacteria,1MUUW@1224|Proteobacteria,2TRG1@28211|Alphaproteobacteria,2K2A7@204457|Sphingomonadales	204457|Sphingomonadales	S	AFG1 family ATPase	-	-	-	ko:K06916	-	-	-	-	ko00000,ko03036	-	-	-	AFG1_ATPase
HKD2_k127_4354675_21	1123267.JONN01000001_gene1677	3.115e-161	521.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales	204457|Sphingomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_4354675_12	1123267.JONN01000001_gene1677	3.007e-193	617.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales	204457|Sphingomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_4354675_43	745310.G432_06210	8.223e-56	201.0	COG1225@1|root,COG1225@2|Bacteria,1RD4R@1224|Proteobacteria,2U6Z9@28211|Alphaproteobacteria,2K4IB@204457|Sphingomonadales	204457|Sphingomonadales	O	Alkyl hydroperoxide reductase	bcp	-	1.11.1.15	ko:K03564	-	-	-	-	ko00000,ko01000	-	-	-	AhpC-TSA
HKD2_k127_4354675_2	1123267.JONN01000001_gene1687	0.0	1019.0	COG1391@1|root,COG1391@2|Bacteria,1MU4I@1224|Proteobacteria,2TRY7@28211|Alphaproteobacteria,2K1YP@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell	glnE	-	2.7.7.42,2.7.7.89	ko:K00982	-	-	-	-	ko00000,ko01000	-	-	-	GlnD_UR_UTase,GlnE
HKD2_k127_4354675_33	1123267.JONN01000001_gene1689	2.712e-112	364.0	COG1595@1|root,COG1595@2|Bacteria,1MZMC@1224|Proteobacteria,2TUUZ@28211|Alphaproteobacteria,2K0TM@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the sigma-70 factor family. ECF subfamily	-	-	-	ko:K03088	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_4354675_54	1470591.BW41_01452	5.303e-05	47.0	2APKU@1|root,31EQ3@2|Bacteria,1QC0Q@1224|Proteobacteria,2VEFJ@28211|Alphaproteobacteria,2K7SA@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4354675_27	1123267.JONN01000001_gene1690	2.515e-137	448.0	COG0784@1|root,COG1595@1|root,COG0784@2|Bacteria,COG1595@2|Bacteria,1MX3Y@1224|Proteobacteria,2TT2R@28211|Alphaproteobacteria,2K0S1@204457|Sphingomonadales	204457|Sphingomonadales	T	In Caulobacter crescentus, CC3477 is differentially expressed in minimal salts media with glucose as compared to complex media	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg,Sigma70_r4_2
HKD2_k127_4354675_26	1123267.JONN01000001_gene1691	2.27e-138	456.0	COG3920@1|root,COG3920@2|Bacteria,1MVPJ@1224|Proteobacteria,2TSSQ@28211|Alphaproteobacteria,2K1HG@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_2
HKD2_k127_4354675_31	1123267.JONN01000001_gene1692	7.781e-123	399.0	COG0805@1|root,COG0805@2|Bacteria,1MVAY@1224|Proteobacteria,2TTIX@28211|Alphaproteobacteria,2K1PD@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides	tatC	-	-	ko:K03118	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	TatC
HKD2_k127_4354675_50	1123267.JONN01000001_gene1693	7.449e-30	123.0	COG1826@1|root,COG1826@2|Bacteria,1N73F@1224|Proteobacteria,2UF4Z@28211|Alphaproteobacteria,2K60Q@204457|Sphingomonadales	204457|Sphingomonadales	U	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation	tatB	-	-	ko:K03117	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_4354675_51	1123267.JONN01000001_gene1694	6.807e-22	98.0	COG1826@1|root,COG1826@2|Bacteria	2|Bacteria	U	protein secretion	tatA	-	-	ko:K03116	ko03060,ko03070,map03060,map03070	M00336	-	-	ko00000,ko00001,ko00002,ko02044	2.A.64	-	-	MttA_Hcf106
HKD2_k127_4354675_37	1123267.JONN01000001_gene1695	3.447e-81	277.0	COG1386@1|root,COG1386@2|Bacteria,1PUA6@1224|Proteobacteria,2TU64@28211|Alphaproteobacteria,2K231@204457|Sphingomonadales	204457|Sphingomonadales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves	scpB	-	-	ko:K06024	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpB
HKD2_k127_4354675_34	392499.Swit_3932	3.491e-106	349.0	COG1354@1|root,COG1354@2|Bacteria,1MVCN@1224|Proteobacteria,2TS1V@28211|Alphaproteobacteria,2K15W@204457|Sphingomonadales	204457|Sphingomonadales	D	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves	scpA	-	-	ko:K05896	-	-	-	-	ko00000,ko03036	-	-	-	SMC_ScpA
HKD2_k127_4354675_9	685778.AORL01000010_gene2580	5.834e-215	680.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S10 serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HKD2_k127_4354675_30	1030157.AFMP01000049_gene75	1.734e-128	419.0	COG1472@1|root,COG1472@2|Bacteria,1MVAJ@1224|Proteobacteria,2TRJK@28211|Alphaproteobacteria,2JZUV@204457|Sphingomonadales	204457|Sphingomonadales	G	beta-N-acetylhexosaminidase	nagZ	-	3.2.1.52	ko:K01207	ko00520,ko00531,ko01100,ko01501,map00520,map00531,map01100,map01501	M00628	R00022,R05963,R07809,R07810,R10831	RC00049	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyco_hydro_3
HKD2_k127_4354675_40	1123267.JONN01000001_gene1698	8.157e-68	237.0	COG3115@1|root,COG3115@2|Bacteria,1RJNQ@1224|Proteobacteria,2UC30@28211|Alphaproteobacteria,2K2NX@204457|Sphingomonadales	204457|Sphingomonadales	D	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR
HKD2_k127_4354675_4	1123267.JONN01000001_gene1700	1.409e-280	872.0	COG0018@1|root,COG0018@2|Bacteria,1MU4J@1224|Proteobacteria,2TS3Y@28211|Alphaproteobacteria,2K0G5@204457|Sphingomonadales	204457|Sphingomonadales	J	Arginyl-tRNA synthetase	argS	-	6.1.1.19	ko:K01887	ko00970,map00970	M00359,M00360	R03646	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Arg_tRNA_synt_N,DALR_1,tRNA-synt_1,tRNA-synt_1d,tRNA-synt_1f
HKD2_k127_4354675_18	1123267.JONN01000001_gene454	1.889e-171	545.0	COG0232@1|root,COG0232@2|Bacteria,1MVQ2@1224|Proteobacteria,2TRCD@28211|Alphaproteobacteria,2K0JG@204457|Sphingomonadales	204457|Sphingomonadales	F	dGTPase family. Type 2 subfamily	dgt	-	3.1.5.1	ko:K01129	ko00230,map00230	-	R01856	RC00017	ko00000,ko00001,ko01000	-	-	-	HD,HD_assoc
HKD2_k127_4354675_42	1123267.JONN01000001_gene453	1.201e-62	232.0	COG0457@1|root,COG5010@1|root,COG0457@2|Bacteria,COG5010@2|Bacteria,1RDU3@1224|Proteobacteria,2U790@28211|Alphaproteobacteria,2KEAN@204457|Sphingomonadales	204457|Sphingomonadales	U	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_19
HKD2_k127_4354675_8	1123267.JONN01000001_gene452	2.937e-219	687.0	COG0206@1|root,COG0206@2|Bacteria,1MV2X@1224|Proteobacteria,2TS1Q@28211|Alphaproteobacteria,2K16V@204457|Sphingomonadales	204457|Sphingomonadales	D	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity	ftsZ	-	-	ko:K03531	ko04112,map04112	-	-	-	ko00000,ko00001,ko02048,ko03036,ko04812	-	-	-	FtsZ_C,Tubulin
HKD2_k127_4354675_38	1502850.FG91_01127	1.41e-76	265.0	COG2271@1|root,COG2271@2|Bacteria,1MVPS@1224|Proteobacteria,2UD2N@28211|Alphaproteobacteria,2KCXQ@204457|Sphingomonadales	204457|Sphingomonadales	G	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_4393299_7	1449076.JOOE01000003_gene3197	1.377e-80	276.0	COG5473@1|root,COG5473@2|Bacteria,1MVRU@1224|Proteobacteria,2TRUD@28211|Alphaproteobacteria,2K414@204457|Sphingomonadales	204457|Sphingomonadales	S	Predicted integral membrane protein (DUF2189)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2189
HKD2_k127_4393299_9	1123267.JONN01000002_gene250	7.201e-56	204.0	COG0335@1|root,COG0335@2|Bacteria,1RH3A@1224|Proteobacteria,2U9DF@28211|Alphaproteobacteria,2K4GC@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site	rplS	-	-	ko:K02884	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L19
HKD2_k127_4393299_3	1123267.JONN01000002_gene249	4.105e-128	419.0	COG0336@1|root,COG0336@2|Bacteria,1MUN1@1224|Proteobacteria,2TSIZ@28211|Alphaproteobacteria,2JZVZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the RNA methyltransferase TrmD family	trmD	-	2.1.1.228	ko:K00554	-	-	R00597	RC00003,RC00334	ko00000,ko01000,ko03016	-	-	-	tRNA_m1G_MT
HKD2_k127_4393299_2	1123267.JONN01000002_gene247	3.895e-134	437.0	COG0492@1|root,COG0492@2|Bacteria,1MVWS@1224|Proteobacteria,2TU6F@28211|Alphaproteobacteria,2K1CC@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin reductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_3
HKD2_k127_4393299_8	1123267.JONN01000002_gene312	1.544e-56	205.0	COG0806@1|root,COG0806@2|Bacteria,1MWQR@1224|Proteobacteria,2U9UT@28211|Alphaproteobacteria,2K4H2@204457|Sphingomonadales	204457|Sphingomonadales	J	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes	rimM	-	-	ko:K02860	-	-	-	-	ko00000,ko03009	-	-	-	PRC,RimM
HKD2_k127_4393299_10	1112212.JH584235_gene653	7.549e-55	200.0	COG0228@1|root,COG0228@2|Bacteria,1MZCT@1224|Proteobacteria,2U94X@28211|Alphaproteobacteria,2K4I6@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bS16 family	rpsP	-	-	ko:K02959	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_S16
HKD2_k127_4393299_0	1123267.JONN01000002_gene310	1.848e-241	753.0	COG0541@1|root,COG0541@2|Bacteria,1MVIA@1224|Proteobacteria,2TQSW@28211|Alphaproteobacteria,2K1DQ@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Interaction with FtsY leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components	ffh	-	3.6.5.4	ko:K03106	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko01000,ko02044	3.A.5.1,3.A.5.2,3.A.5.7,3.A.5.8,3.A.5.9	-	-	SRP54,SRP54_N,SRP_SPB
HKD2_k127_4393299_11	1123267.JONN01000001_gene1125	5.595e-34	135.0	2BPFV@1|root,32I85@2|Bacteria,1Q8G2@1224|Proteobacteria,2VEP2@28211|Alphaproteobacteria,2K6XS@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4393299_4	1549858.MC45_16795	6.173e-125	407.0	COG0189@1|root,COG0189@2|Bacteria,1R5VK@1224|Proteobacteria,2U2DG@28211|Alphaproteobacteria,2K2UA@204457|Sphingomonadales	204457|Sphingomonadales	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	CPSase_L_D2,RimK
HKD2_k127_4393299_1	1470591.BW41_00929	8.211e-173	548.0	COG2141@1|root,COG2141@2|Bacteria,1MWMV@1224|Proteobacteria,2VFM8@28211|Alphaproteobacteria,2KDYF@204457|Sphingomonadales	204457|Sphingomonadales	C	Luciferase-like monooxygenase	-	-	1.14.14.35	ko:K17228	ko00920,map00920	-	R10203	RC02556,RC03080	ko00000,ko00001,ko01000	-	-	-	Bac_luciferase
HKD2_k127_4393299_5	1123267.JONN01000001_gene1124	3.558e-110	364.0	COG0253@1|root,COG0253@2|Bacteria,1MWDH@1224|Proteobacteria,2TUF2@28211|Alphaproteobacteria,2K1PV@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan	dapF	-	5.1.1.7	ko:K01778	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00527	R02735	RC00302	ko00000,ko00001,ko00002,ko01000	-	-	-	DAP_epimerase
HKD2_k127_4393299_6	627192.SLG_23460	1.167e-92	311.0	COG0621@1|root,COG0621@2|Bacteria,1MUCS@1224|Proteobacteria,2TRYD@28211|Alphaproteobacteria,2K0WZ@204457|Sphingomonadales	204457|Sphingomonadales	J	2-methylthioadenine	-	-	2.8.4.5	ko:K18707	-	-	R10649	RC00003,RC03221	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,UPF0004
HKD2_k127_453729_3	983920.Y88_3692	6.718e-25	109.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U4WG@28211|Alphaproteobacteria,2K1X8@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_453729_2	1088721.NSU_0483	1.109e-60	220.0	COG1028@1|root,COG1028@2|Bacteria,1MUFX@1224|Proteobacteria,2TVKK@28211|Alphaproteobacteria,2KCPF@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_453729_1	1030157.AFMP01000065_gene1148	1.573e-73	252.0	COG0103@1|root,COG0103@2|Bacteria,1RD4A@1224|Proteobacteria,2U5B5@28211|Alphaproteobacteria,2K0C7@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the universal ribosomal protein uS9 family	rpsI	-	-	ko:K02996	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S9
HKD2_k127_453729_0	1123267.JONN01000002_gene257	9.719e-95	312.0	COG0102@1|root,COG0102@2|Bacteria,1RA11@1224|Proteobacteria,2U5FM@28211|Alphaproteobacteria,2K28X@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly	rplM	-	-	ko:K02871	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L13
HKD2_k127_4736781_128	1331060.RLDS_14290	1.959e-43	166.0	COG3803@1|root,COG3803@2|Bacteria,1RHYI@1224|Proteobacteria,2U7AN@28211|Alphaproteobacteria,2K570@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF924
HKD2_k127_4736781_14	1030157.AFMP01000016_gene2506	4.058e-239	747.0	COG0312@1|root,COG0312@2|Bacteria,1MUSK@1224|Proteobacteria,2TRSR@28211|Alphaproteobacteria,2JZY8@204457|Sphingomonadales	204457|Sphingomonadales	S	peptidase U62, modulator of DNA gyrase	tldD	-	-	ko:K03568	-	-	-	-	ko00000,ko01002	-	-	-	PmbA_TldD
HKD2_k127_4736781_147	1550073.JROH01000001_gene542	2.144e-21	95.0	COG4391@1|root,COG4391@2|Bacteria,1N7F4@1224|Proteobacteria,2UHY4@28211|Alphaproteobacteria,2K6U4@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	zf-CHCC
HKD2_k127_4736781_162	1123267.JONN01000001_gene2187	4.681e-10	68.0	2EKFG@1|root,33E5M@2|Bacteria,1NJ6W@1224|Proteobacteria,2UJND@28211|Alphaproteobacteria,2KBN4@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4402
HKD2_k127_4736781_43	1123267.JONN01000001_gene2188	1.615e-151	484.0	COG1131@1|root,COG1131@2|Bacteria,1MUW7@1224|Proteobacteria,2TR2Q@28211|Alphaproteobacteria,2K06G@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type multidrug transport system, ATPase component	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_4736781_8	1123267.JONN01000001_gene2189	3.051e-279	865.0	COG0029@1|root,COG0029@2|Bacteria,1RBQW@1224|Proteobacteria,2TS0E@28211|Alphaproteobacteria,2JZXW@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the oxidation of L-aspartate to iminoaspartate	nadB	-	1.4.3.16	ko:K00278	ko00250,ko00760,ko01100,map00250,map00760,map01100	M00115	R00357,R00481	RC00006,RC02566	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_2,Succ_DH_flav_C
HKD2_k127_4736781_118	1114964.L485_19365	8.215e-51	183.0	COG3686@1|root,COG3686@2|Bacteria,1N00R@1224|Proteobacteria,2U94Y@28211|Alphaproteobacteria,2K6NU@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD2_k127_4736781_2	745310.G432_11300	0.0	1282.0	COG0258@1|root,COG0749@1|root,COG0258@2|Bacteria,COG0749@2|Bacteria,1MU31@1224|Proteobacteria,2TRJF@28211|Alphaproteobacteria,2K1KW@204457|Sphingomonadales	204457|Sphingomonadales	L	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity	polA	-	2.7.7.7	ko:K02335	ko00230,ko00240,ko01100,ko03030,ko03410,ko03420,ko03440,map00230,map00240,map01100,map03030,map03410,map03420,map03440	-	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	5_3_exonuc,5_3_exonuc_N,DNA_pol_A,DNA_pol_A_exo1
HKD2_k127_4736781_29	1123267.JONN01000001_gene2194	7.563e-178	573.0	COG2244@1|root,COG2244@2|Bacteria,1PDRG@1224|Proteobacteria,2TVKM@28211|Alphaproteobacteria,2K0P5@204457|Sphingomonadales	204457|Sphingomonadales	S	Polysaccharide biosynthesis protein	-	-	-	-	-	-	-	-	-	-	-	-	Polysacc_synt,Polysacc_synt_3
HKD2_k127_4736781_11	1192759.AKIB01000103_gene3290	4.185e-261	812.0	COG0138@1|root,COG0138@2|Bacteria,1MUDQ@1224|Proteobacteria,2TRMY@28211|Alphaproteobacteria,2K0R5@204457|Sphingomonadales	204457|Sphingomonadales	F	Bifunctional purine biosynthesis protein PurH	purH	-	2.1.2.3,3.5.4.10	ko:K00602	ko00230,ko00670,ko01100,ko01110,ko01130,ko01523,map00230,map00670,map01100,map01110,map01130,map01523	M00048	R01127,R04560	RC00026,RC00263,RC00456	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	AICARFT_IMPCHas,MGS
HKD2_k127_4736781_15	1123267.JONN01000001_gene2196	1.196e-229	724.0	COG5360@1|root,COG5360@2|Bacteria,1MUJ4@1224|Proteobacteria,2TR5G@28211|Alphaproteobacteria,2K1RQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Heparinase	-	-	-	-	-	-	-	-	-	-	-	-	Hepar_II_III
HKD2_k127_4736781_61	1123267.JONN01000001_gene2197	3.457e-113	368.0	COG0036@1|root,COG0036@2|Bacteria,1MUZM@1224|Proteobacteria,2TQKR@28211|Alphaproteobacteria,2K1ZB@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the ribulose-phosphate 3-epimerase family	rpe	-	5.1.3.1	ko:K01783	ko00030,ko00040,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00040,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01529	RC00540	ko00000,ko00001,ko00002,ko01000	-	-	-	Ribul_P_3_epim
HKD2_k127_4736781_49	1090320.KB900605_gene1258	3.166e-140	456.0	COG0144@1|root,COG0144@2|Bacteria,1MWPE@1224|Proteobacteria,2TSIA@28211|Alphaproteobacteria,2K0U7@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F,NusB
HKD2_k127_4736781_54	1123267.JONN01000001_gene2200	1.727e-130	424.0	COG0240@1|root,COG0240@2|Bacteria,1MUU3@1224|Proteobacteria,2TT75@28211|Alphaproteobacteria,2K0GB@204457|Sphingomonadales	204457|Sphingomonadales	I	Glycerol-3-phosphate dehydrogenase	gpsA	-	1.1.1.94	ko:K00057	ko00564,ko01110,map00564,map01110	-	R00842,R00844	RC00029	ko00000,ko00001,ko01000	-	-	-	NAD_Gly3P_dh_C,NAD_Gly3P_dh_N
HKD2_k127_4736781_30	1123267.JONN01000001_gene2201	1.607e-171	547.0	COG0533@1|root,COG0533@2|Bacteria,1MU6S@1224|Proteobacteria,2TSF7@28211|Alphaproteobacteria,2K0S9@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction	tsaD	-	2.3.1.234	ko:K01409	-	-	R10648	RC00070,RC00416	ko00000,ko01000,ko03016	-	-	-	Peptidase_M22
HKD2_k127_4736781_76	685778.AORL01000022_gene1646	9.828e-100	333.0	COG0181@1|root,COG0181@2|Bacteria,1MU56@1224|Proteobacteria,2TS3D@28211|Alphaproteobacteria,2K19Y@204457|Sphingomonadales	204457|Sphingomonadales	H	Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps	hemC	-	2.5.1.61	ko:K01749	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R00084	RC02317	ko00000,ko00001,ko00002,ko01000	-	-	-	Porphobil_deam,Porphobil_deamC
HKD2_k127_4736781_124	1123267.JONN01000001_gene2203	1.19e-46	178.0	COG1587@1|root,COG1587@2|Bacteria,1NMTP@1224|Proteobacteria,2UMED@28211|Alphaproteobacteria,2K52Q@204457|Sphingomonadales	204457|Sphingomonadales	H	Uroporphyrinogen-III synthase	hemD	-	4.2.1.75	ko:K01719	ko00860,ko01100,ko01110,ko01120,map00860,map01100,map01110,map01120	M00121	R03165	RC01861	ko00000,ko00001,ko00002,ko01000	-	-	-	HEM4
HKD2_k127_4736781_83	1123267.JONN01000001_gene2204	1.263e-76	265.0	291EX@1|root,2ZP1S@2|Bacteria,1RF3T@1224|Proteobacteria,2U83Z@28211|Alphaproteobacteria,2K4S8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Mitofilin
HKD2_k127_4736781_55	1123267.JONN01000001_gene2205	2.872e-130	426.0	COG2367@1|root,COG2367@2|Bacteria,1PNSR@1224|Proteobacteria,2U483@28211|Alphaproteobacteria,2K1SY@204457|Sphingomonadales	204457|Sphingomonadales	V	beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,Peptidase_S13
HKD2_k127_4736781_24	1336243.JAEA01000012_gene3006	3.625e-195	619.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,1JRDR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_4736781_134	366602.Caul_5342	1.2e-34	136.0	COG1426@1|root,COG1426@2|Bacteria,1N2UF@1224|Proteobacteria,2UDEY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_4736781_137	278963.ATWD01000001_gene1138	4.316e-30	123.0	COG3550@1|root,COG3550@2|Bacteria,3Y5G9@57723|Acidobacteria,2JJW5@204432|Acidobacteriia	204432|Acidobacteriia	S	Pfam:HipA_N	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
HKD2_k127_4736781_116	1219035.NT2_06_00980	5.482e-52	191.0	COG3550@1|root,COG3550@2|Bacteria,1N458@1224|Proteobacteria,2TVQF@28211|Alphaproteobacteria,2K4RK@204457|Sphingomonadales	204457|Sphingomonadales	S	Pfam:HipA_N	-	-	-	-	-	-	-	-	-	-	-	-	Couple_hipA,HipA_C
HKD2_k127_4736781_159	935261.JAGL01000024_gene1	6.501e-15	83.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,rve,rve_3
HKD2_k127_4736781_161	1445613.JALM01000099_gene4526	7.854e-13	80.0	2B84S@1|root,321CY@2|Bacteria,2H5C8@201174|Actinobacteria	201174|Actinobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_114	522373.Smlt1846B	2.84e-53	202.0	COG0714@1|root,COG0714@2|Bacteria,1NEPS@1224|Proteobacteria	1224|Proteobacteria	S	PFAM ATPase associated with various cellular activities, AAA_5	-	-	-	-	-	-	-	-	-	-	-	-	AAA_5
HKD2_k127_4736781_168	522373.Smlt1844B	0.0002561	53.0	2EYWA@1|root,33S38@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_47	522373.Smlt1844A	9.244e-142	463.0	COG0863@1|root,COG1743@1|root,COG0863@2|Bacteria,COG1743@2|Bacteria,1PNW1@1224|Proteobacteria,1TATW@1236|Gammaproteobacteria,1XBPD@135614|Xanthomonadales	135614|Xanthomonadales	H	(EC 2.1.1.113) (N-4 cytosine-specific methyltransferase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_4736781_51	522373.Smlt1844	1.115e-138	456.0	COG0863@1|root,COG0863@2|Bacteria,1PNW1@1224|Proteobacteria,1TATW@1236|Gammaproteobacteria,1XBPD@135614|Xanthomonadales	2|Bacteria	H	(EC 2.1.1.113) (N-4 cytosine-specific methyltransferase	-	-	2.1.1.113	ko:K00590	-	-	-	-	ko00000,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_4736781_123	1331060.RLDS_21490	2.39e-47	174.0	2DEYX@1|root,2ZPU1@2|Bacteria,1NCCE@1224|Proteobacteria,2UHWU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_64	1121890.AUDO01000004_gene2014	1.271e-110	367.0	arCOG12670@1|root,2Z95Y@2|Bacteria,4NHJ5@976|Bacteroidetes,1IDF7@117743|Flavobacteriia,2NY7H@237|Flavobacterium	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_95	1331060.RLDS_21375	8.121e-66	230.0	COG1961@1|root,COG1961@2|Bacteria,1R5CS@1224|Proteobacteria,2U18D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Resolvase
HKD2_k127_4736781_6	85643.Tmz1t_1478	1.205e-279	870.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_4736781_165	1267005.KB911257_gene842	1.053e-06	61.0	COG4313@1|root,COG4313@2|Bacteria,1PC95@1224|Proteobacteria,2U0FJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_4736781_78	313598.MED152_06985	1.912e-93	327.0	COG3659@1|root,COG3659@2|Bacteria,4P49P@976|Bacteroidetes,1I9MV@117743|Flavobacteriia	976|Bacteroidetes	M	Carbohydrate-selective porin, OprB family	-	-	-	ko:K07267	-	-	-	-	ko00000,ko02000	1.B.19.1	-	-	OprB
HKD2_k127_4736781_148	383381.EH30_12965	3.261e-21	97.0	2E428@1|root,32YYS@2|Bacteria,1NJ5X@1224|Proteobacteria,2UK83@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_42	1331060.RLDS_21500	2.717e-153	496.0	COG0582@1|root,COG0582@2|Bacteria,1R4UZ@1224|Proteobacteria,2U0XX@28211|Alphaproteobacteria,2K3QA@204457|Sphingomonadales	204457|Sphingomonadales	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD2_k127_4736781_163	698769.JFBD01000042_gene814	2.181e-07	55.0	2DR03@1|root,339MB@2|Bacteria,1VK6Y@1239|Firmicutes,4HR34@91061|Bacilli	91061|Bacilli	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_70	1123267.JONN01000001_gene2207	2.945e-108	360.0	COG3118@1|root,COG3118@2|Bacteria,1MV0R@1224|Proteobacteria,2TS5X@28211|Alphaproteobacteria,2K0HB@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	ko:K05838	-	-	-	-	ko00000,ko03110	-	-	-	TPR_15,TPR_19,TPR_20,Thioredoxin
HKD2_k127_4736781_89	1123267.JONN01000001_gene2208	2.722e-73	255.0	COG2802@1|root,COG2802@2|Bacteria,1NV9N@1224|Proteobacteria,2TQZ4@28211|Alphaproteobacteria,2K0QK@204457|Sphingomonadales	204457|Sphingomonadales	S	to the N-terminal domain of Lon protease	-	-	-	ko:K07157	-	-	-	-	ko00000	-	-	-	LON_substr_bdg
HKD2_k127_4736781_35	1123267.JONN01000001_gene2209	1.031e-165	534.0	COG0654@1|root,COG0654@2|Bacteria,1MU6I@1224|Proteobacteria,2TRZU@28211|Alphaproteobacteria,2JZY3@204457|Sphingomonadales	204457|Sphingomonadales	CH	Ubiquinone biosynthesis hydroxylase, UbiH UbiF VisC COQ6 family	-	-	-	ko:K03185	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00117	R04989,R08773	RC02670	ko00000,ko00001,ko00002,ko01000	-	-	-	FAD_binding_3
HKD2_k127_4736781_4	392499.Swit_3663	8.545e-301	942.0	COG1674@1|root,COG1674@2|Bacteria,1MVPI@1224|Proteobacteria,2TR48@28211|Alphaproteobacteria,2K02P@204457|Sphingomonadales	204457|Sphingomonadales	D	DNA segregation ATPase FtsK SpoIIIE	ftsK	-	-	ko:K03466	-	-	-	-	ko00000,ko03036	3.A.12	-	-	FtsK_4TM,FtsK_SpoIIIE,Ftsk_gamma
HKD2_k127_4736781_117	1123267.JONN01000001_gene2137	1.563e-51	192.0	COG2834@1|root,COG2834@2|Bacteria,1RA1S@1224|Proteobacteria,2U58W@28211|Alphaproteobacteria,2K43J@204457|Sphingomonadales	204457|Sphingomonadales	M	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)	lolA	-	-	-	-	-	-	-	-	-	-	-	LolA
HKD2_k127_4736781_50	1123267.JONN01000001_gene2138	5.102e-140	447.0	COG0708@1|root,COG0708@2|Bacteria,1MVMC@1224|Proteobacteria,2TRWQ@28211|Alphaproteobacteria,2K09T@204457|Sphingomonadales	204457|Sphingomonadales	L	exodeoxyribonuclease III	-	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_4736781_57	1123267.JONN01000001_gene2139	2.655e-124	408.0	COG0807@1|root,COG0807@2|Bacteria,1MWZR@1224|Proteobacteria,2TR82@28211|Alphaproteobacteria,2K0DD@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate	ribA	-	3.5.4.25	ko:K01497	ko00740,ko00790,ko01100,ko01110,ko02024,map00740,map00790,map01100,map01110,map02024	M00125	R00425	RC00293,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydro2
HKD2_k127_4736781_87	1219049.SP5_043_00210	3.529e-74	257.0	COG0637@1|root,COG0637@2|Bacteria,1NSPA@1224|Proteobacteria,2U0W3@28211|Alphaproteobacteria,2K05N@204457|Sphingomonadales	204457|Sphingomonadales	S	Haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_4736781_84	1123267.JONN01000001_gene2140	2.583e-76	261.0	COG0325@1|root,COG0325@2|Bacteria,1MWN7@1224|Proteobacteria,2TR5Z@28211|Alphaproteobacteria,2K0C6@204457|Sphingomonadales	204457|Sphingomonadales	S	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis	-	-	-	ko:K06997	-	-	-	-	ko00000	-	-	-	Ala_racemase_N
HKD2_k127_4736781_160	1030157.AFMP01000004_gene2061	3.396e-14	79.0	COG0352@1|root,COG0352@2|Bacteria,1RKGX@1224|Proteobacteria,2UB4W@28211|Alphaproteobacteria,2K57F@204457|Sphingomonadales	204457|Sphingomonadales	H	Thiamine monophosphate synthase	-	-	2.5.1.3	ko:K00788	ko00730,ko01100,map00730,map01100	M00127	R03223,R10712	RC00224,RC03255,RC03397	ko00000,ko00001,ko00002,ko01000	-	-	-	TMP-TENI
HKD2_k127_4736781_99	1123267.JONN01000001_gene2142	2.514e-61	219.0	2C7BT@1|root,33MZ9@2|Bacteria,1NMQ4@1224|Proteobacteria,2UG5B@28211|Alphaproteobacteria,2K40I@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Porin_4
HKD2_k127_4736781_111	1123267.JONN01000001_gene2143	1.514e-56	200.0	2C2J5@1|root,315UG@2|Bacteria,1RHAH@1224|Proteobacteria,2U94W@28211|Alphaproteobacteria,2K4E5@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF3576)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3576
HKD2_k127_4736781_0	1123267.JONN01000001_gene2144	0.0	1373.0	COG0495@1|root,COG0495@2|Bacteria,1MV47@1224|Proteobacteria,2TQPK@28211|Alphaproteobacteria,2K0Q0@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	leuS	-	6.1.1.4	ko:K01869	ko00970,map00970	M00359,M00360	R03657	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	Anticodon_1,tRNA-synt_1,tRNA-synt_1_2
HKD2_k127_4736781_113	1550073.JROH01000008_gene1730	1.748e-53	193.0	COG5468@1|root,COG5468@2|Bacteria,1RKF8@1224|Proteobacteria,2UACI@28211|Alphaproteobacteria,2K4FJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Lipopolysaccharide-assembly	-	-	-	ko:K03643	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptE
HKD2_k127_4736781_82	1030157.AFMP01000004_gene2055	3.686e-83	290.0	COG1466@1|root,COG1466@2|Bacteria,1N7AB@1224|Proteobacteria,2UHPM@28211|Alphaproteobacteria,2K0ER@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III	holA	-	2.7.7.7	ko:K02340	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta
HKD2_k127_4736781_75	1030157.AFMP01000004_gene2054	1.045e-101	340.0	COG1475@1|root,COG1475@2|Bacteria,1MW2E@1224|Proteobacteria,2TSTN@28211|Alphaproteobacteria,2K0RQ@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the ParB family	parB	-	-	ko:K03497	-	-	-	-	ko00000,ko03000,ko03036,ko04812	-	-	-	ParBc
HKD2_k127_4736781_59	1030157.AFMP01000004_gene2053	1.914e-122	398.0	COG1192@1|root,COG1192@2|Bacteria,1MV43@1224|Proteobacteria,2TSWH@28211|Alphaproteobacteria,2K02Z@204457|Sphingomonadales	204457|Sphingomonadales	D	Chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_4736781_122	46429.BV95_03191	2.149e-47	179.0	COG0357@1|root,COG0357@2|Bacteria,1MY0K@1224|Proteobacteria,2U9T9@28211|Alphaproteobacteria,2K4N2@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N7 position of guanine in position 527 of 16S rRNA	rsmG	-	2.1.1.170	ko:K03501	-	-	-	-	ko00000,ko01000,ko03009,ko03036	-	-	-	GidB
HKD2_k127_4736781_27	1007104.SUS17_2150	2.603e-181	583.0	COG0445@1|root,COG0445@2|Bacteria,1MU6F@1224|Proteobacteria,2TRJS@28211|Alphaproteobacteria,2K05A@204457|Sphingomonadales	204457|Sphingomonadales	D	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34	gidA	-	-	ko:K03495	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko03016,ko03036	-	-	-	GIDA,GIDA_assoc
HKD2_k127_4736781_58	1449076.JOOE01000003_gene3725	5.843e-123	407.0	COG0486@1|root,COG0486@2|Bacteria,1MUCQ@1224|Proteobacteria,2TQZW@28211|Alphaproteobacteria,2K0HT@204457|Sphingomonadales	204457|Sphingomonadales	J	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34	mnmE	-	-	ko:K03650	-	-	R08701	RC00053,RC00209,RC00870	ko00000,ko01000,ko03016	-	-	-	MMR_HSR1,MnmE_helical,TrmE_N
HKD2_k127_4736781_81	1502850.FG91_01793	9.837e-86	288.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,2K1SQ@204457|Sphingomonadales	204457|Sphingomonadales	P	membrane protein, TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD2_k127_4736781_88	1123267.JONN01000001_gene2153	3.789e-74	259.0	COG0861@1|root,COG0861@2|Bacteria,1PN8B@1224|Proteobacteria,2TUV5@28211|Alphaproteobacteria,2K1SQ@204457|Sphingomonadales	204457|Sphingomonadales	P	membrane protein, TerC	-	-	-	-	-	-	-	-	-	-	-	-	TerC
HKD2_k127_4736781_12	1123267.JONN01000001_gene2154	1.021e-249	773.0	COG1158@1|root,COG1158@2|Bacteria,1MUCF@1224|Proteobacteria,2TRB4@28211|Alphaproteobacteria,2K1UD@204457|Sphingomonadales	204457|Sphingomonadales	K	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template	rho	-	-	ko:K03628	ko03018,map03018	-	-	-	ko00000,ko00001,ko03019,ko03021	-	-	-	ATP-synt_ab,Rho_N,Rho_RNA_bind
HKD2_k127_4736781_100	1123267.JONN01000001_gene2155	3.788e-61	215.0	COG1981@1|root,COG1981@2|Bacteria,1RHGS@1224|Proteobacteria,2U987@28211|Alphaproteobacteria,2K4J9@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	ko:K08973	-	-	-	-	ko00000	-	-	-	UPF0093
HKD2_k127_4736781_41	1123269.NX02_25420	3.399e-155	496.0	COG0407@1|root,COG0407@2|Bacteria,1MUG1@1224|Proteobacteria,2TQQV@28211|Alphaproteobacteria,2JZZP@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	hemE	-	4.1.1.37	ko:K01599	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R03197,R04972	RC00872	ko00000,ko00001,ko00002,ko01000	-	-	-	URO-D
HKD2_k127_4736781_94	1123267.JONN01000001_gene2157	2.543e-66	231.0	COG0424@1|root,COG0424@2|Bacteria,1RDA9@1224|Proteobacteria,2U9H5@28211|Alphaproteobacteria,2K2S3@204457|Sphingomonadales	204457|Sphingomonadales	D	Maf-like protein	-	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_4736781_101	1123267.JONN01000001_gene2159	4.507e-61	221.0	COG0237@1|root,COG0237@2|Bacteria,1RCXT@1224|Proteobacteria,2U765@28211|Alphaproteobacteria,2K3YB@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A	coaE	-	2.7.1.24	ko:K00859	ko00770,ko01100,map00770,map01100	M00120	R00130	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	CoaE
HKD2_k127_4736781_77	1479239.JQMU01000001_gene1435	6.535e-99	327.0	COG0847@1|root,COG0847@2|Bacteria,1MV8Z@1224|Proteobacteria,2TTFF@28211|Alphaproteobacteria,2K06H@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease	dnaQ	-	2.7.7.7	ko:K02342	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	RNase_T
HKD2_k127_4736781_92	1030157.AFMP01000004_gene2036	1.043e-66	232.0	COG1544@1|root,COG1544@2|Bacteria,1MZHW@1224|Proteobacteria,2TV3J@28211|Alphaproteobacteria,2K2CA@204457|Sphingomonadales	204457|Sphingomonadales	J	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase	hpf	-	-	-	-	-	-	-	-	-	-	-	Ribosom_S30AE_C,Ribosomal_S30AE
HKD2_k127_4736781_110	1123267.JONN01000001_gene2162	4.485e-57	202.0	COG1762@1|root,COG1762@2|Bacteria,1RD0E@1224|Proteobacteria,2U7B0@28211|Alphaproteobacteria,2K6E5@204457|Sphingomonadales	204457|Sphingomonadales	G	PTS IIA-like nitrogen-regulatory protein PtsN	ptsN	-	-	ko:K02806	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	PTS_EIIA_2
HKD2_k127_4736781_153	1346791.M529_17075	4.347e-18	93.0	COG5447@1|root,COG5447@2|Bacteria,1N1KU@1224|Proteobacteria,2UFES@28211|Alphaproteobacteria,2K70S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1491)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1491
HKD2_k127_4736781_103	1123267.JONN01000001_gene2165	1.619e-59	214.0	COG3773@1|root,COG3773@2|Bacteria,1RDSV@1224|Proteobacteria,2U8XY@28211|Alphaproteobacteria,2K4PG@204457|Sphingomonadales	204457|Sphingomonadales	M	COG3773 Cell wall hydrolyses involved in spore germination	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
HKD2_k127_4736781_96	1123267.JONN01000001_gene2166	1.431e-64	224.0	COG5321@1|root,COG5321@2|Bacteria,1RDXW@1224|Proteobacteria,2U73Y@28211|Alphaproteobacteria,2K5GG@204457|Sphingomonadales	204457|Sphingomonadales	S	DNA repair protein MmcB-like	-	-	-	-	-	-	-	-	-	-	-	-	MmcB-like
HKD2_k127_4736781_131	1123267.JONN01000001_gene2167	3.039e-38	151.0	COG0666@1|root,COG0666@2|Bacteria,1RFFD@1224|Proteobacteria,2U8T6@28211|Alphaproteobacteria,2K4S6@204457|Sphingomonadales	204457|Sphingomonadales	S	Ankyrin repeat	-	-	-	-	-	-	-	-	-	-	-	-	Ank,Ank_2,Ank_4,Ank_5
HKD2_k127_4736781_91	1123267.JONN01000001_gene2168	6.888e-70	238.0	COG2983@1|root,COG2983@2|Bacteria,1RHMX@1224|Proteobacteria,2U99S@28211|Alphaproteobacteria,2K4JE@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0260 family	-	-	-	ko:K09160	-	-	-	-	ko00000	-	-	-	CxxCxxCC
HKD2_k127_4736781_133	1248917.ANFX01000029_gene2649	3.201e-35	144.0	COG1451@1|root,COG1451@2|Bacteria,1MXZU@1224|Proteobacteria,2U1JG@28211|Alphaproteobacteria,2K287@204457|Sphingomonadales	204457|Sphingomonadales	S	Metal-dependent hydrolase	-	-	-	ko:K07043	-	-	-	-	ko00000	-	-	-	DUF45
HKD2_k127_4736781_5	1123267.JONN01000001_gene2170	3.177e-299	932.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,2K0HX@204457|Sphingomonadales	204457|Sphingomonadales	M	penicillin-binding protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD2_k127_4736781_130	1123267.JONN01000001_gene2172	1.693e-38	150.0	2AGZR@1|root,3178H@2|Bacteria,1NJBM@1224|Proteobacteria,2UJXF@28211|Alphaproteobacteria,2K8AT@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4402
HKD2_k127_4736781_144	1123267.JONN01000001_gene2124	6.484e-24	107.0	2EKFG@1|root,33E5M@2|Bacteria,1NJ6W@1224|Proteobacteria,2UJAN@28211|Alphaproteobacteria,2K84W@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4402
HKD2_k127_4736781_152	1123267.JONN01000001_gene2124	2.424e-18	91.0	2EKFG@1|root,33E5M@2|Bacteria,1NJ6W@1224|Proteobacteria,2UJAN@28211|Alphaproteobacteria,2K84W@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4402)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4402
HKD2_k127_4736781_79	1123267.JONN01000001_gene2123	8.095e-93	313.0	COG3121@1|root,COG3121@2|Bacteria,1RFSJ@1224|Proteobacteria,2U926@28211|Alphaproteobacteria,2K4YS@204457|Sphingomonadales	204457|Sphingomonadales	NU	COG3121 P pilus assembly protein, chaperone PapD	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_9	1123267.JONN01000001_gene2122	7.364e-266	846.0	COG3188@1|root,COG3188@2|Bacteria,1R6ZJ@1224|Proteobacteria,2U0NW@28211|Alphaproteobacteria,2K2TI@204457|Sphingomonadales	204457|Sphingomonadales	NU	usher protein	-	-	-	-	-	-	-	-	-	-	-	-	CarboxypepD_reg
HKD2_k127_4736781_126	1123267.JONN01000001_gene2120	3.794e-45	175.0	2E521@1|root,32ZVA@2|Bacteria,1RF95@1224|Proteobacteria,2U8QW@28211|Alphaproteobacteria,2K2DR@204457|Sphingomonadales	204457|Sphingomonadales	S	zinc-ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	zinc_ribbon_4
HKD2_k127_4736781_68	1123267.JONN01000001_gene2119	3.22e-109	364.0	COG2884@1|root,COG2884@2|Bacteria,1MVQ4@1224|Proteobacteria,2TS9Y@28211|Alphaproteobacteria,2JZVB@204457|Sphingomonadales	204457|Sphingomonadales	D	cell division	ftsE	-	-	ko:K09812	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	ABC_tran
HKD2_k127_4736781_119	1030157.AFMP01000014_gene3385	1.313e-49	188.0	COG2177@1|root,COG2177@2|Bacteria,1MXKQ@1224|Proteobacteria,2TSNT@28211|Alphaproteobacteria,2K43P@204457|Sphingomonadales	204457|Sphingomonadales	D	Cell division protein	ftsX	-	-	ko:K09811	ko02010,map02010	M00256	-	-	ko00000,ko00001,ko00002,ko02000,ko03036	3.A.1.140	-	-	FtsX
HKD2_k127_4736781_108	1123267.JONN01000001_gene2117	3.101e-58	208.0	COG1434@1|root,COG1434@2|Bacteria,1RHMV@1224|Proteobacteria,2U957@28211|Alphaproteobacteria,2K4KS@204457|Sphingomonadales	204457|Sphingomonadales	S	DUF218 domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF218
HKD2_k127_4736781_90	1123267.JONN01000001_gene2116	1.441e-72	252.0	COG0204@1|root,COG0204@2|Bacteria,1MY51@1224|Proteobacteria,2TT3P@28211|Alphaproteobacteria,2K3XJ@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyltransferase	plsC	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_4736781_3	745310.G432_11785	0.0	1047.0	COG0072@1|root,COG0073@1|root,COG0072@2|Bacteria,COG0073@2|Bacteria,1MWKS@1224|Proteobacteria,2TQV8@28211|Alphaproteobacteria,2K02I@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily	pheT	-	6.1.1.20	ko:K01890	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	B3_4,B5,FDX-ACB,tRNA_bind
HKD2_k127_4736781_33	392499.Swit_2429	4.482e-167	532.0	COG0016@1|root,COG0016@2|Bacteria,1MVD7@1224|Proteobacteria,2TS2T@28211|Alphaproteobacteria,2K0XB@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily	pheS	-	6.1.1.20	ko:K01889	ko00970,map00970	M00359,M00360	R03660	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Phe_tRNA-synt_N,tRNA-synt_2d
HKD2_k127_4736781_60	1123267.JONN01000001_gene2109	2.959e-122	400.0	28HGI@1|root,2Z7SC@2|Bacteria,1MWKC@1224|Proteobacteria,2TUQY@28211|Alphaproteobacteria,2K00Y@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_52	1035191.HMPREF0185_02902	2.008e-136	452.0	COG1396@1|root,COG3800@1|root,COG1396@2|Bacteria,COG3800@2|Bacteria,1MU50@1224|Proteobacteria,2TRKE@28211|Alphaproteobacteria,2KG4K@204458|Caulobacterales	204458|Caulobacterales	K	IrrE N-terminal-like domain	-	-	-	ko:K07110	-	-	-	-	ko00000,ko03000	-	-	-	DUF2083,HTH_31,Peptidase_M78
HKD2_k127_4736781_16	1449076.JOOE01000004_gene304	5.262e-222	698.0	COG2224@1|root,COG2224@2|Bacteria,1MWIF@1224|Proteobacteria,2TU0Q@28211|Alphaproteobacteria,2K0CD@204457|Sphingomonadales	204457|Sphingomonadales	C	Isocitrate lyase	aceA	-	4.1.3.1	ko:K01637	ko00630,ko01100,ko01110,ko01120,ko01200,map00630,map01100,map01110,map01120,map01200	M00012	R00479	RC00311,RC00313	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL
HKD2_k127_4736781_17	59538.XP_005968329.1	3.02e-219	692.0	COG2225@1|root,KOG1261@2759|Eukaryota,38GR5@33154|Opisthokonta,3BGP2@33208|Metazoa,3D0YI@33213|Bilateria,48BT1@7711|Chordata,492XM@7742|Vertebrata,3JG6K@40674|Mammalia	33208|Metazoa	C	Malate synthase	icl-1	GO:0003674,GO:0003824,GO:0004451,GO:0004474,GO:0005975,GO:0006081,GO:0006082,GO:0006097,GO:0007275,GO:0007568,GO:0008150,GO:0008152,GO:0008340,GO:0009987,GO:0010259,GO:0016740,GO:0016746,GO:0016829,GO:0016830,GO:0016833,GO:0019752,GO:0032501,GO:0032502,GO:0032787,GO:0043436,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0046487,GO:0046912,GO:0048856,GO:0071704	2.3.3.9,4.1.3.1	ko:K01637,ko:K01638	ko00620,ko00630,ko01100,ko01110,ko01120,ko01200,map00620,map00630,map01100,map01110,map01120,map01200	M00012	R00472,R00479	RC00004,RC00308,RC00311,RC00313,RC02747	ko00000,ko00001,ko00002,ko01000	-	-	-	ICL,Malate_synthase,PEP_mutase
HKD2_k127_4736781_140	991.IW20_10980	6.441e-27	118.0	COG2928@1|root,COG2928@2|Bacteria,4NT13@976|Bacteroidetes,1I204@117743|Flavobacteriia,2NU8Q@237|Flavobacterium	976|Bacteroidetes	S	Protein of unknown function (DUF502)	-	-	-	-	-	-	-	-	-	-	-	-	DUF502
HKD2_k127_4736781_105	1192759.AKIB01000100_gene3459	1.519e-58	204.0	COG0292@1|root,COG0292@2|Bacteria,1RGU2@1224|Proteobacteria,2U756@28211|Alphaproteobacteria,2K4FX@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit	rplT	-	-	ko:K02887	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L20
HKD2_k127_4736781_135	1123267.JONN01000001_gene2106	1.86e-34	134.0	COG0291@1|root,COG0291@2|Bacteria,1N6V4@1224|Proteobacteria,2UF6K@28211|Alphaproteobacteria,2K5YR@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL35 family	rpmI	-	-	ko:K02916	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L35p
HKD2_k127_4736781_73	287.DR97_4102	1.73e-102	353.0	COG0223@1|root,COG0223@2|Bacteria,1NN5V@1224|Proteobacteria	1224|Proteobacteria	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	-	-	-	-	-	-	-	-	-	-	-	-	Formyl_trans_N
HKD2_k127_4736781_106	1123267.JONN01000001_gene2105	2.276e-58	215.0	COG1028@1|root,COG1028@2|Bacteria,1RHYX@1224|Proteobacteria,2TUR9@28211|Alphaproteobacteria,2K4MT@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_4736781_36	1123267.JONN01000001_gene2128	5.115e-165	524.0	COG0462@1|root,COG0462@2|Bacteria,1MW21@1224|Proteobacteria,2TR4Y@28211|Alphaproteobacteria,2K0MQ@204457|Sphingomonadales	204457|Sphingomonadales	F	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)	prs	-	2.7.6.1	ko:K00948	ko00030,ko00230,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map00230,map01100,map01110,map01120,map01130,map01200,map01230	M00005	R01049	RC00002,RC00078	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyl_synth,Pribosyltran_N
HKD2_k127_4736781_13	1123267.JONN01000001_gene2129	8.067e-241	755.0	COG0171@1|root,COG0388@1|root,COG0171@2|Bacteria,COG0388@2|Bacteria,1MU9U@1224|Proteobacteria,2TRAU@28211|Alphaproteobacteria,2K0R3@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source	nadE	-	6.3.1.5	ko:K01916	ko00760,ko01100,map00760,map01100	M00115	R00189	RC00100	ko00000,ko00001,ko00002,ko01000	-	-	-	CN_hydrolase,NAD_synthase
HKD2_k127_4736781_23	1123267.JONN01000001_gene2130	4.415e-196	619.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRCI@28211|Alphaproteobacteria,2K0M4@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX2	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_4736781_44	1123267.JONN01000001_gene2133	1.22e-147	477.0	COG0117@1|root,COG1985@1|root,COG0117@2|Bacteria,COG1985@2|Bacteria,1MUWT@1224|Proteobacteria,2TR70@28211|Alphaproteobacteria,2K10R@204457|Sphingomonadales	204457|Sphingomonadales	H	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate	ribD	-	1.1.1.193,3.5.4.26	ko:K11752	ko00740,ko01100,ko01110,ko02024,map00740,map01100,map01110,map02024	M00125	R03458,R03459	RC00204,RC00933	ko00000,ko00001,ko00002,ko01000	-	-	-	RibD_C,dCMP_cyt_deam_1
HKD2_k127_4736781_80	1123267.JONN01000001_gene2134	1.07e-91	306.0	COG0307@1|root,COG0307@2|Bacteria,1MUMB@1224|Proteobacteria,2U3RS@28211|Alphaproteobacteria,2K0MU@204457|Sphingomonadales	204457|Sphingomonadales	H	Riboflavin synthase	ribE	-	2.5.1.9	ko:K00793	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R00066	RC00958,RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	Lum_binding
HKD2_k127_4736781_18	1123267.JONN01000001_gene2135	5.543e-219	685.0	COG0108@1|root,COG0108@2|Bacteria,1MU8P@1224|Proteobacteria,2TSMA@28211|Alphaproteobacteria,2K1FG@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate	ribB	-	3.5.4.25,4.1.99.12	ko:K14652	ko00740,ko00790,ko01100,ko01110,map00740,map00790,map01100,map01110	M00125,M00840	R00425,R07281	RC00293,RC01792,RC01815,RC02504	ko00000,ko00001,ko00002,ko01000	-	-	-	DHBP_synthase,GTP_cyclohydro2
HKD2_k127_4736781_109	1549858.MC45_13610	1.545e-57	205.0	COG0054@1|root,COG0054@2|Bacteria,1RD9J@1224|Proteobacteria,2U9IZ@28211|Alphaproteobacteria,2K4FR@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin	ribH	-	2.5.1.78	ko:K00794	ko00740,ko01100,ko01110,map00740,map01100,map01110	M00125	R04457	RC00960	ko00000,ko00001,ko00002,ko01000	-	-	-	DMRL_synthase
HKD2_k127_4736781_53	1131813.AQVT01000001_gene3093	7.806e-133	433.0	COG1902@1|root,COG1902@2|Bacteria,1MVIX@1224|Proteobacteria,2TT2F@28211|Alphaproteobacteria,1JS7Z@119045|Methylobacteriaceae	28211|Alphaproteobacteria	C	NADH flavin oxidoreductase NADH oxidase	-	-	-	ko:K10680	ko00633,ko01120,map00633,map01120	-	R08014,R08017,R08042	RC00250	ko00000,ko00001,ko01000	-	-	-	Oxidored_FMN
HKD2_k127_4736781_62	1123267.JONN01000001_gene2213	3.617e-112	370.0	COG0697@1|root,COG0697@2|Bacteria,1RCED@1224|Proteobacteria,2U66Q@28211|Alphaproteobacteria,2K1CY@204457|Sphingomonadales	204457|Sphingomonadales	EG	COG0697 Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_4736781_85	1123267.JONN01000001_gene2214	3.103e-76	261.0	COG5590@1|root,COG5590@2|Bacteria,1MW25@1224|Proteobacteria,2U9ST@28211|Alphaproteobacteria,2K3VY@204457|Sphingomonadales	204457|Sphingomonadales	S	RpsU-divergently transcribed	-	-	-	ko:K18587	-	-	-	-	ko00000	-	-	-	COQ9
HKD2_k127_4736781_139	1123267.JONN01000001_gene2215	2.242e-27	113.0	COG1918@1|root,COG1918@2|Bacteria,1N7XK@1224|Proteobacteria,2UI27@28211|Alphaproteobacteria,2K6S7@204457|Sphingomonadales	204457|Sphingomonadales	P	Fe2 transport system protein A	feoA	-	-	ko:K04758	-	-	-	-	ko00000,ko02000	-	-	-	FeoA
HKD2_k127_4736781_7	1123267.JONN01000001_gene2216	2.527e-279	872.0	COG0370@1|root,COG0370@2|Bacteria,1MUZC@1224|Proteobacteria,2TQSU@28211|Alphaproteobacteria,2K0AQ@204457|Sphingomonadales	204457|Sphingomonadales	P	Ferrous iron transport protein B	feoB	-	-	ko:K04759	-	-	-	-	ko00000,ko02000	9.A.8.1	-	-	FeoB_C,FeoB_N,Gate
HKD2_k127_4736781_98	1123269.NX02_28030	9.958e-63	225.0	COG0629@1|root,COG0629@2|Bacteria,1RCWT@1224|Proteobacteria,2U5BZ@28211|Alphaproteobacteria,2K464@204457|Sphingomonadales	204457|Sphingomonadales	L	Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism	-	-	-	ko:K03111	ko03030,ko03430,ko03440,map03030,map03430,map03440	-	-	-	ko00000,ko00001,ko03029,ko03032,ko03400	-	-	-	SSB
HKD2_k127_4736781_115	1123267.JONN01000001_gene2218	2.673e-52	192.0	COG1399@1|root,COG1399@2|Bacteria,1N7C2@1224|Proteobacteria,2UC4J@28211|Alphaproteobacteria,2K4K6@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, COG1399	-	-	-	-	-	-	-	-	-	-	-	-	DUF177
HKD2_k127_4736781_138	1123267.JONN01000001_gene2219	1.829e-27	121.0	COG5452@1|root,COG5452@2|Bacteria,1N12T@1224|Proteobacteria,2UCES@28211|Alphaproteobacteria,2K5B4@204457|Sphingomonadales	204457|Sphingomonadales	S	Ubiquinol-cytochrome C chaperone	-	-	-	ko:K17662	-	-	-	-	ko00000,ko03029	-	-	-	Ubiq_cyt_C_chap
HKD2_k127_4736781_125	1346791.M529_03420	6.162e-46	170.0	COG2913@1|root,COG2913@2|Bacteria,1RHYM@1224|Proteobacteria,2UBU9@28211|Alphaproteobacteria,2K4H5@204457|Sphingomonadales	204457|Sphingomonadales	J	Small protein A (tmRNA-binding)	-	-	-	-	-	-	-	-	-	-	-	-	SmpA_OmlA
HKD2_k127_4736781_69	1123267.JONN01000001_gene2221	5.852e-109	357.0	COG3483@1|root,COG3483@2|Bacteria,1MW68@1224|Proteobacteria,2TRXV@28211|Alphaproteobacteria,2K1B3@204457|Sphingomonadales	204457|Sphingomonadales	E	Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety	kynA	GO:0003674,GO:0003824,GO:0004833,GO:0005488,GO:0006082,GO:0006520,GO:0006568,GO:0006569,GO:0006576,GO:0006586,GO:0006725,GO:0006807,GO:0008150,GO:0008152,GO:0009056,GO:0009063,GO:0009072,GO:0009074,GO:0009308,GO:0009310,GO:0009987,GO:0016043,GO:0016054,GO:0016491,GO:0016701,GO:0016702,GO:0019439,GO:0019441,GO:0019752,GO:0020037,GO:0022607,GO:0034641,GO:0042180,GO:0042402,GO:0042430,GO:0042436,GO:0042537,GO:0043436,GO:0043933,GO:0044085,GO:0044106,GO:0044237,GO:0044238,GO:0044248,GO:0044270,GO:0044281,GO:0044282,GO:0046218,GO:0046395,GO:0046483,GO:0046700,GO:0046906,GO:0048037,GO:0051213,GO:0051259,GO:0051260,GO:0051262,GO:0051289,GO:0055114,GO:0065003,GO:0070189,GO:0071704,GO:0071840,GO:0097159,GO:1901360,GO:1901361,GO:1901363,GO:1901564,GO:1901565,GO:1901575,GO:1901605,GO:1901606	1.13.11.11	ko:K00453	ko00380,ko01100,map00380,map01100	M00038	R00678	RC00356	ko00000,ko00001,ko00002,ko01000	-	-	-	Trp_dioxygenase
HKD2_k127_4736781_48	1123267.JONN01000001_gene2222	1.388e-140	456.0	COG0520@1|root,COG0520@2|Bacteria,1Q7AQ@1224|Proteobacteria,2VCMD@28211|Alphaproteobacteria,2K2Q9@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_4736781_34	1123267.JONN01000001_gene2225	7.831e-166	531.0	COG2271@1|root,COG2271@2|Bacteria,1MWYR@1224|Proteobacteria,2TSXW@28211|Alphaproteobacteria,2K1KD@204457|Sphingomonadales	204457|Sphingomonadales	G	COG0477 Permeases of the major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_4736781_132	1123267.JONN01000001_gene2226	3.493e-37	158.0	29ZIU@1|root,30MJ0@2|Bacteria,1RF6K@1224|Proteobacteria,2U8DV@28211|Alphaproteobacteria,2K50U@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_141	1504672.669783747	1.113e-26	117.0	COG2335@1|root,COG2335@2|Bacteria,1RD06@1224|Proteobacteria,2VSZ8@28216|Betaproteobacteria,4ADFB@80864|Comamonadaceae	28216|Betaproteobacteria	M	Beta-Ig-H3 fasciclin	-	-	-	-	-	-	-	-	-	-	-	-	Fasciclin
HKD2_k127_4736781_22	1123267.JONN01000001_gene2229	2.711e-207	647.0	COG0592@1|root,COG0592@2|Bacteria,1MVD9@1224|Proteobacteria,2TSRZ@28211|Alphaproteobacteria,2K052@204457|Sphingomonadales	204457|Sphingomonadales	L	Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria	dnaN	-	2.7.7.7	ko:K02338	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_beta,DNA_pol3_beta_2,DNA_pol3_beta_3
HKD2_k127_4736781_158	394221.Mmar10_2891	5.078e-15	85.0	2EKD9@1|root,315NU@2|Bacteria,1RKEM@1224|Proteobacteria,2V74J@28211|Alphaproteobacteria,4402H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_45	1123267.JONN01000001_gene2234	1.59e-146	471.0	COG1195@1|root,COG1195@2|Bacteria,1MX8N@1224|Proteobacteria,2TQRD@28211|Alphaproteobacteria,2K0WV@204457|Sphingomonadales	204457|Sphingomonadales	L	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP	recF	-	-	ko:K03629	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	SMC_N
HKD2_k127_4736781_19	194867.ALBQ01000001_gene3003	1.042e-213	673.0	COG0624@1|root,COG0624@2|Bacteria,1MWJS@1224|Proteobacteria,2TUHT@28211|Alphaproteobacteria,2K1MW@204457|Sphingomonadales	204457|Sphingomonadales	E	Acetylornithine deacetylase Succinyl-diaminopimelate	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_4736781_40	629773.AORY01000014_gene2465	5.795e-157	512.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,2K0U4@204457|Sphingomonadales	204457|Sphingomonadales	L	DEAD DEAH box helicase	-	-	3.6.4.13	ko:K11927	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	DEAD,Helicase_C
HKD2_k127_4736781_1	1123267.JONN01000001_gene2239	0.0	1372.0	COG0187@1|root,COG0187@2|Bacteria,1MVKT@1224|Proteobacteria,2TRBK@28211|Alphaproteobacteria,2K0E4@204457|Sphingomonadales	204457|Sphingomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrB	-	5.99.1.3	ko:K02470	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseB,DNA_gyraseB_C,HATPase_c,Toprim
HKD2_k127_4736781_63	1123267.JONN01000001_gene2240	1.14e-110	364.0	COG3568@1|root,COG3568@2|Bacteria,1MVN7@1224|Proteobacteria,2U1MH@28211|Alphaproteobacteria,2K0EG@204457|Sphingomonadales	204457|Sphingomonadales	L	endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	Exo_endo_phos
HKD2_k127_4736781_38	1007104.SUS17_3009	3.182e-158	512.0	COG1508@1|root,COG1508@2|Bacteria,1MW4V@1224|Proteobacteria,2TS41@28211|Alphaproteobacteria,2K182@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released	rpoN	-	-	ko:K03092	ko02020,ko05111,map02020,map05111	-	-	-	ko00000,ko00001,ko03021	-	-	-	Sigma54_AID,Sigma54_CBD,Sigma54_DBD
HKD2_k127_4736781_56	1123267.JONN01000001_gene2242	7.379e-129	415.0	COG1137@1|root,COG1137@2|Bacteria,1MU8M@1224|Proteobacteria,2TR7F@28211|Alphaproteobacteria,2K0YX@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC-type (Unclassified) transport system, ATPase component	-	-	-	ko:K06861	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	1.B.42.1	-	-	ABC_tran,BCA_ABC_TP_C
HKD2_k127_4736781_104	1123267.JONN01000001_gene2243	2.105e-59	217.0	COG1934@1|root,COG1934@2|Bacteria,1MXGA@1224|Proteobacteria,2U6DD@28211|Alphaproteobacteria,2K3YP@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09774	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA
HKD2_k127_4736781_102	1123267.JONN01000001_gene2244	7.908e-61	218.0	COG5375@1|root,COG5375@2|Bacteria,1NMV8@1224|Proteobacteria,2VCS4@28211|Alphaproteobacteria,2K34V@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein conserved in bacteria	-	-	-	ko:K11719	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	LptC
HKD2_k127_4736781_74	1123267.JONN01000001_gene2245	4.654e-102	336.0	COG0349@1|root,COG0349@2|Bacteria,1MWFD@1224|Proteobacteria,2TQXS@28211|Alphaproteobacteria,2K0FG@204457|Sphingomonadales	204457|Sphingomonadales	L	3'-5' exonuclease	-	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1
HKD2_k127_4736781_66	1123267.JONN01000001_gene2246	1.486e-109	362.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2JZZ2@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold shock	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_4736781_31	1123269.NX02_19010	1.477e-170	554.0	COG2939@1|root,COG2939@2|Bacteria,1MW05@1224|Proteobacteria,2TS7R@28211|Alphaproteobacteria,2K0U5@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S10 serine carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S10
HKD2_k127_4736781_32	1112216.JH594425_gene1603	3.016e-167	536.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2TTYC@28211|Alphaproteobacteria,2K0Q2@204457|Sphingomonadales	204457|Sphingomonadales	Q	COG1228 Imidazolonepropionase and related amidohydrolases	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_4736781_10	1123267.JONN01000001_gene2256	1.134e-261	814.0	COG1793@1|root,COG1793@2|Bacteria,1MV3S@1224|Proteobacteria,2TRQ9@28211|Alphaproteobacteria,2K08Z@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP-dependent DNA ligase	-	-	6.5.1.1,6.5.1.6,6.5.1.7	ko:K10747	ko03030,ko03410,ko03420,ko03430,map03030,map03410,map03420,map03430	-	R00381,R00382,R10822,R10823	RC00005	ko00000,ko00001,ko01000,ko03032,ko03400	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M,DNA_ligase_A_N
HKD2_k127_4736781_142	1331060.RLDS_12675	4.659e-25	106.0	COG0267@1|root,COG0267@2|Bacteria,1N6QV@1224|Proteobacteria,2UF4D@28211|Alphaproteobacteria,2K6VC@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL33 family	rpmG	-	-	ko:K02913	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L33
HKD2_k127_4736781_127	1123267.JONN01000001_gene2253	7.637e-44	167.0	COG0745@1|root,COG0745@2|Bacteria,1RD7E@1224|Proteobacteria,2U745@28211|Alphaproteobacteria,2K53C@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	ko:K11443	ko02020,ko04112,map02020,map04112	M00511	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD2_k127_4736781_150	745310.G432_12055	1.342e-20	93.0	2DMKE@1|root,32S6E@2|Bacteria,1NH3D@1224|Proteobacteria,2UHAS@28211|Alphaproteobacteria,2K72S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3572)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3572
HKD2_k127_4736781_72	1123267.JONN01000001_gene2250	1.362e-103	343.0	COG4221@1|root,COG4221@2|Bacteria,1MUF8@1224|Proteobacteria,2TR5S@28211|Alphaproteobacteria,2K1R4@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	1.1.1.276	ko:K05886	-	-	-	-	ko00000,ko01000	-	-	-	adh_short
HKD2_k127_4736781_93	1123267.JONN01000001_gene2249	2.066e-66	238.0	COG0251@1|root,COG0251@2|Bacteria,1RHMZ@1224|Proteobacteria,2U9H4@28211|Alphaproteobacteria,2K4U7@204457|Sphingomonadales	204457|Sphingomonadales	J	endoribonuclease	-	-	-	-	-	-	-	-	-	-	-	-	YjgF_endoribonc
HKD2_k127_4736781_37	1123267.JONN01000001_gene2247	1.643e-158	509.0	COG3146@1|root,COG3146@2|Bacteria,1MU35@1224|Proteobacteria,2TS5I@28211|Alphaproteobacteria,2K1NQ@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09919	-	-	-	-	ko00000	-	-	-	FemAB_like
HKD2_k127_4736781_71	1090320.KB900605_gene911	6.144e-106	352.0	COG1446@1|root,COG1446@2|Bacteria,1MWFC@1224|Proteobacteria,2TU8K@28211|Alphaproteobacteria,2K0JU@204457|Sphingomonadales	204457|Sphingomonadales	E	Asparaginase	-	-	3.4.19.5	ko:K13051	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Asparaginase_2
HKD2_k127_4736781_46	1123267.JONN01000001_gene2259	4.202e-143	460.0	COG0330@1|root,COG0330@2|Bacteria,1P8ZI@1224|Proteobacteria,2TTBE@28211|Alphaproteobacteria,2JZUP@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Band_7
HKD2_k127_4736781_149	1090320.KB900605_gene915	6.122e-21	93.0	COG4877@1|root,COG4877@2|Bacteria,1NJMT@1224|Proteobacteria,2UK5B@28211|Alphaproteobacteria,2K6XY@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	HicB
HKD2_k127_4736781_155	1112216.JH594425_gene851	4.667e-16	81.0	2AM6W@1|root,31C1H@2|Bacteria,1Q7ZT@1224|Proteobacteria,2VE5I@28211|Alphaproteobacteria,2K706@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_86	1123267.JONN01000002_gene287	3.314e-75	275.0	COG0758@1|root,COG0758@2|Bacteria,1R9P1@1224|Proteobacteria,2U30Q@28211|Alphaproteobacteria,2K3JF@204457|Sphingomonadales	204457|Sphingomonadales	LU	DNA mediated transformation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_67	1248917.ANFX01000011_gene167	2.346e-109	381.0	COG0457@1|root,COG0457@2|Bacteria,1N06S@1224|Proteobacteria,2TQVV@28211|Alphaproteobacteria,2K2KZ@204457|Sphingomonadales	204457|Sphingomonadales	S	MTH538 TIR-like domain (DUF1863)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1863
HKD2_k127_4736781_20	1088721.NSU_1564	9.157e-210	657.0	COG0821@1|root,COG0821@2|Bacteria,1MUAX@1224|Proteobacteria,2TQSI@28211|Alphaproteobacteria,2K1FA@204457|Sphingomonadales	204457|Sphingomonadales	I	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate	ispG	-	1.17.7.1,1.17.7.3	ko:K03526	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R08689,R10859	RC01486	ko00000,ko00001,ko00002,ko01000	-	-	-	GcpE
HKD2_k127_4736781_97	745310.G432_08300	1.364e-63	233.0	COG0697@1|root,COG0697@2|Bacteria,1RC7K@1224|Proteobacteria,2U0HX@28211|Alphaproteobacteria,2KDGS@204457|Sphingomonadales	204457|Sphingomonadales	EG	EamA-like transporter family	-	-	-	ko:K15270	-	-	-	-	ko00000,ko02000	2.A.7.3.7	-	-	EamA
HKD2_k127_4736781_107	1123269.NX02_29060	3.058e-58	212.0	COG4291@1|root,COG4291@2|Bacteria,1RGUF@1224|Proteobacteria,2TRCQ@28211|Alphaproteobacteria,2K1VR@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1345)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1345
HKD2_k127_4736781_129	745310.G432_08285	1.083e-42	162.0	COG2076@1|root,COG2076@2|Bacteria,1MZ6P@1224|Proteobacteria,2UBR4@28211|Alphaproteobacteria,2K583@204457|Sphingomonadales	204457|Sphingomonadales	P	Small Multidrug Resistance protein	-	-	-	ko:K11741	-	-	-	-	ko00000,ko02000	2.A.7.1	-	-	Multi_Drug_Res
HKD2_k127_4736781_28	1248916.ANFY01000007_gene2485	6.525e-180	576.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TV11@28211|Alphaproteobacteria,2K0M0@204457|Sphingomonadales	204457|Sphingomonadales	J	Asp-tRNAAsn Glu-tRNAGln amidotransferase A subunit	-	-	3.5.1.4	ko:K01426	ko00330,ko00360,ko00380,ko00627,ko00643,ko01120,map00330,map00360,map00380,map00627,map00643,map01120	-	R02540,R03096,R03180,R03909,R05551,R05590	RC00010,RC00100,RC00950,RC01025	ko00000,ko00001,ko01000	-	-	-	Amidase
HKD2_k127_4736781_21	1123267.JONN01000001_gene2271	1.432e-208	685.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MXFM@1224|Proteobacteria,2TWYV@28211|Alphaproteobacteria,2K14T@204457|Sphingomonadales	204457|Sphingomonadales	H	Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_4736781_39	1123267.JONN01000001_gene2271	5.202e-158	527.0	COG1629@1|root,COG4206@1|root,COG4206@2|Bacteria,COG4771@2|Bacteria,1MXFM@1224|Proteobacteria,2TWYV@28211|Alphaproteobacteria,2K14T@204457|Sphingomonadales	204457|Sphingomonadales	H	Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_4736781_25	745310.G432_10630	3.594e-184	584.0	COG0124@1|root,COG0124@2|Bacteria,1MV2K@1224|Proteobacteria,2TSTH@28211|Alphaproteobacteria,2K101@204457|Sphingomonadales	204457|Sphingomonadales	J	histidyl-tRNA synthetase	hisS	-	6.1.1.21	ko:K01892	ko00970,map00970	M00359,M00360	R03655	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_His
HKD2_k127_4736781_26	1123267.JONN01000001_gene2275	2.29e-181	573.0	COG0216@1|root,COG0216@2|Bacteria,1MV28@1224|Proteobacteria,2TQSV@28211|Alphaproteobacteria,2K1M6@204457|Sphingomonadales	204457|Sphingomonadales	J	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA	prfA	-	-	ko:K02835	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_4736781_65	1123267.JONN01000001_gene2276	4.048e-110	362.0	COG2890@1|root,COG2890@2|Bacteria,1MXCQ@1224|Proteobacteria,2TZFK@28211|Alphaproteobacteria,2K12S@204457|Sphingomonadales	204457|Sphingomonadales	J	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif	prmC	-	2.1.1.297	ko:K02493	-	-	R10806	RC00003,RC03279	ko00000,ko01000,ko03012	-	-	-	MTS,Methyltransf_31
HKD2_k127_4736781_120	1123267.JONN01000001_gene2277	1.556e-49	185.0	COG5373@1|root,COG5373@2|Bacteria,1N7JV@1224|Proteobacteria,2TR7A@28211|Alphaproteobacteria,2K53N@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4167)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4167
HKD2_k127_4736781_112	1123267.JONN01000001_gene2280	4.137e-54	197.0	COG1607@1|root,COG1607@2|Bacteria,1MZAZ@1224|Proteobacteria,2U93J@28211|Alphaproteobacteria,2K591@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA hydrolase	-	-	-	ko:K10806	ko01040,map01040	-	-	-	ko00000,ko00001,ko01000,ko01004	-	-	-	4HBT
HKD2_k127_4736781_164	1123267.JONN01000001_gene2281	6.092e-07	57.0	2ACU7@1|root,312F7@2|Bacteria,1N510@1224|Proteobacteria,2UDTR@28211|Alphaproteobacteria,2K7QW@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4736781_121	1449076.JOOE01000004_gene624	8.557e-48	175.0	COG0517@1|root,COG0517@2|Bacteria,1N0H3@1224|Proteobacteria,2UC0F@28211|Alphaproteobacteria,2K5EC@204457|Sphingomonadales	204457|Sphingomonadales	S	CBS domain	-	-	-	-	-	-	-	-	-	-	-	-	CBS
HKD2_k127_4736781_146	1382230.ASAP_2763	1.447e-23	99.0	2DPM9@1|root,332MQ@2|Bacteria,1NAPW@1224|Proteobacteria,2UWJH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_4778890_2	864069.MicloDRAFT_00005050	4.457e-88	299.0	COG4584@1|root,COG4584@2|Bacteria,1MWIV@1224|Proteobacteria,2TQKF@28211|Alphaproteobacteria,1JZ16@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_23,rve
HKD2_k127_4778890_0	1366050.N234_30415	8.693e-182	586.0	COG5421@1|root,COG5421@2|Bacteria,1R3NX@1224|Proteobacteria,2VZHX@28216|Betaproteobacteria,1K341@119060|Burkholderiaceae	28216|Betaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1
HKD2_k127_4778890_3	504832.OCAR_7446	1.137e-15	81.0	COG3311@1|root,COG3311@2|Bacteria	2|Bacteria	K	DNA excision	-	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_4778890_1	504832.OCAR_7447	3.359e-108	362.0	COG4974@1|root,COG4974@2|Bacteria,1MW8V@1224|Proteobacteria,2U289@28211|Alphaproteobacteria,3K2EE@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Phage integrase family	-	-	-	-	-	-	-	-	-	-	-	-	Phage_integrase
HKD2_k127_4915731_0	685778.AORL01000021_gene434	1.695e-168	536.0	COG1228@1|root,COG1228@2|Bacteria,1MVAF@1224|Proteobacteria,2U4WG@28211|Alphaproteobacteria,2K1X8@204457|Sphingomonadales	204457|Sphingomonadales	Q	Amidohydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1
HKD2_k127_4915731_2	1123267.JONN01000002_gene255	2.734e-80	276.0	COG1834@1|root,COG1834@2|Bacteria,1MZ9U@1224|Proteobacteria,2TT08@28211|Alphaproteobacteria,2K7DA@204457|Sphingomonadales	204457|Sphingomonadales	E	Amidinotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Amidinotransf
HKD2_k127_4915731_1	1123267.JONN01000001_gene1042	6.419e-160	509.0	COG0667@1|root,COG0667@2|Bacteria,1MVEH@1224|Proteobacteria,2TRHS@28211|Alphaproteobacteria,2K0VS@204457|Sphingomonadales	204457|Sphingomonadales	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_4915731_4	745310.G432_08250	6.075e-10	69.0	COG1872@1|root,COG1872@2|Bacteria,1NGWG@1224|Proteobacteria,2V55P@28211|Alphaproteobacteria,2K6B7@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0235 family	-	-	-	ko:K09131	-	-	-	-	ko00000	-	-	-	DUF167
HKD2_k127_4915731_3	1123267.JONN01000001_gene1041	9.345e-50	181.0	COG0477@1|root,COG2814@2|Bacteria,1MU1I@1224|Proteobacteria,2TVXT@28211|Alphaproteobacteria,2JZYF@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	ko:K03446	-	M00701	-	-	ko00000,ko00002,ko02000	2.A.1.3	-	-	MFS_1
HKD2_k127_5027270_7	1349767.GJA_2162	2.915e-54	200.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2VR1X@28216|Betaproteobacteria,47627@75682|Oxalobacteraceae	28216|Betaproteobacteria	K	LysR substrate binding domain	-	-	-	ko:K03566	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5027270_2	1079460.ATTQ01000003_gene1587	1.083e-74	261.0	COG0451@1|root,COG0451@2|Bacteria,1Q5Q6@1224|Proteobacteria,2UQC0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	GM	ADP-glyceromanno-heptose 6-epimerase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5027270_10	1079460.ATTQ01000003_gene1586	1.033e-27	124.0	COG1280@1|root,COG1280@2|Bacteria,1RA1G@1224|Proteobacteria,2USXF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	E	LysE type translocator	-	-	-	-	-	-	-	-	-	-	-	-	LysE
HKD2_k127_5027270_4	1120705.FG95_01347	1.956e-63	222.0	COG1247@1|root,COG1247@2|Bacteria,1RDF5@1224|Proteobacteria,2U73C@28211|Alphaproteobacteria,2K4EC@204457|Sphingomonadales	204457|Sphingomonadales	M	Acetyltransferase (GNAT) family	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_4
HKD2_k127_5027270_5	935557.ATYB01000009_gene957	7.03e-62	215.0	COG0607@1|root,COG0607@2|Bacteria,1RHUS@1224|Proteobacteria,2U9CN@28211|Alphaproteobacteria,4BF0Q@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	rhodanese-related sulfurtransferase	-	-	-	-	-	-	-	-	-	-	-	-	Rhodanese
HKD2_k127_5027270_6	243233.MCA0074	1.258e-58	209.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,1RRI3@1236|Gammaproteobacteria,1XFAZ@135618|Methylococcales	135618|Methylococcales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N
HKD2_k127_5027270_1	1174684.EBMC1_08561	5.158e-77	270.0	COG2249@1|root,COG2249@2|Bacteria,1MUHN@1224|Proteobacteria,2U15Z@28211|Alphaproteobacteria,2K63S@204457|Sphingomonadales	204457|Sphingomonadales	S	Flavodoxin-like fold	-	-	1.6.5.2	ko:K00355	ko00130,ko01110,ko05200,ko05225,ko05418,map00130,map01110,map05200,map05225,map05418	-	R02964,R03643,R03816	RC00819	ko00000,ko00001,ko01000	-	-	-	Flavodoxin_2
HKD2_k127_5027270_8	279238.Saro_0972	1.972e-46	172.0	COG5485@1|root,COG5485@2|Bacteria,1N268@1224|Proteobacteria	1224|Proteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL
HKD2_k127_5027270_3	1206741.BAFX01000082_gene6199	7.05e-67	241.0	COG1063@1|root,COG1063@2|Bacteria,2GNS1@201174|Actinobacteria,4FZCF@85025|Nocardiaceae	201174|Actinobacteria	E	Alcohol dehydrogenase GroES-like domain	-	-	1.1.1.1	ko:K00001	ko00010,ko00071,ko00350,ko00625,ko00626,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01220,map00010,map00071,map00350,map00625,map00626,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01220	-	R00623,R00754,R02124,R04805,R04880,R05233,R05234,R06917,R06927,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_5027270_9	1079460.ATTQ01000029_gene4715	4.869e-30	122.0	2EB9J@1|root,335A2@2|Bacteria,1NFB9@1224|Proteobacteria,2UFMK@28211|Alphaproteobacteria,4BGP7@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_31
HKD2_k127_5027270_0	13689.BV96_04481	7.663e-83	278.0	COG3550@1|root,COG3550@2|Bacteria,1MVAB@1224|Proteobacteria,2U1TN@28211|Alphaproteobacteria,2K0KG@204457|Sphingomonadales	204457|Sphingomonadales	S	protein related to capsule biosynthesis enzymes	-	-	2.7.11.1	ko:K07154	-	-	-	-	ko00000,ko01000,ko01001,ko02048	-	-	-	Couple_hipA,HipA_C
HKD2_k127_5061325_0	1030157.AFMP01000009_gene3634	8.662e-173	556.0	COG0488@1|root,COG0488@2|Bacteria,1MV25@1224|Proteobacteria,2TSJ9@28211|Alphaproteobacteria,2K1DF@204457|Sphingomonadales	204457|Sphingomonadales	S	of ABC transporters with duplicated ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran
HKD2_k127_5061325_3	1278073.MYSTI_00209	8.157e-17	86.0	COG4891@1|root,COG4891@2|Bacteria,1N4U1@1224|Proteobacteria,43BZB@68525|delta/epsilon subdivisions,2X7A2@28221|Deltaproteobacteria,2Z284@29|Myxococcales	28221|Deltaproteobacteria	S	Polyketide cyclase / dehydrase and lipid transport	-	-	-	-	-	-	-	-	-	-	-	-	Polyketide_cyc2
HKD2_k127_5061325_2	13690.CP98_05010	2.524e-19	93.0	COG0671@1|root,COG0671@2|Bacteria,1RGM4@1224|Proteobacteria,2UIYA@28211|Alphaproteobacteria,2K5MY@204457|Sphingomonadales	204457|Sphingomonadales	I	Acid phosphatase homologues	-	-	-	-	-	-	-	-	-	-	-	-	PAP2
HKD2_k127_5061325_4	319003.Bra1253DRAFT_02997	1.062e-06	55.0	2EQ0D@1|root,33HKU@2|Bacteria,1N7ES@1224|Proteobacteria,2UF3T@28211|Alphaproteobacteria,3K0WY@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	MA20_44835	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5061325_5	279238.Saro_3192	0.0002769	49.0	29TSX@1|root,30F17@2|Bacteria,1P8SZ@1224|Proteobacteria,2UWJI@28211|Alphaproteobacteria,2KBMM@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5061325_1	1030157.AFMP01000019_gene589	6.955e-38	146.0	COG0782@1|root,COG0782@2|Bacteria,1MZNY@1224|Proteobacteria,2UC6B@28211|Alphaproteobacteria,2K6K7@204457|Sphingomonadales	204457|Sphingomonadales	J	Transcription elongation factor, GreA/GreB, C-term	-	-	-	ko:K06140	-	-	-	-	ko00000,ko03000	-	-	-	GreA_GreB
HKD2_k127_5061325_6	1122137.AQXF01000003_gene2070	0.0008731	44.0	COG0583@1|root,COG0583@2|Bacteria,1NUCI@1224|Proteobacteria,2UDW2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	LysR substrate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5169895_1	443598.AUFA01000032_gene6453	2.487e-66	233.0	2A5M1@1|root,30UBM@2|Bacteria,1PYHZ@1224|Proteobacteria,2U052@28211|Alphaproteobacteria,3JW2K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Trypsin-like peptidase domain	-	-	-	-	-	-	-	-	-	-	-	-	Trypsin_2
HKD2_k127_5169895_0	1411123.JQNH01000001_gene838	4.401e-198	634.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,PAS_4,PAS_7
HKD2_k127_5171720_2	1007104.SUS17_1890	3.73e-187	592.0	COG0154@1|root,COG0154@2|Bacteria,1MUVQ@1224|Proteobacteria,2TRFY@28211|Alphaproteobacteria,2K0UD@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln)	gatA	-	6.3.5.6,6.3.5.7	ko:K02433	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Amidase
HKD2_k127_5171720_16	1123267.JONN01000002_gene124	1.208e-40	153.0	COG0721@1|root,COG0721@2|Bacteria,1MZQP@1224|Proteobacteria,2UBSZ@28211|Alphaproteobacteria,2K5XM@204457|Sphingomonadales	204457|Sphingomonadales	J	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)	gatC	-	6.3.5.6,6.3.5.7	ko:K02435	ko00970,ko01100,map00970,map01100	-	R03905,R04212	RC00010	ko00000,ko00001,ko01000,ko03029	-	-	-	Glu-tRNAGln
HKD2_k127_5171720_14	1392838.AWNM01000095_gene3180	6.983e-51	186.0	COG2930@1|root,COG2930@2|Bacteria,1RAIB@1224|Proteobacteria,2VT65@28216|Betaproteobacteria,3T64N@506|Alcaligenaceae	28216|Betaproteobacteria	S	Las17-binding protein actin regulator	-	-	-	-	-	-	-	-	-	-	-	-	Ysc84
HKD2_k127_5171720_18	1218075.BAYA01000053_gene6880	8.687e-37	143.0	COG4420@1|root,COG4420@2|Bacteria,1P3R0@1224|Proteobacteria,2W6Z4@28216|Betaproteobacteria,1KDBY@119060|Burkholderiaceae	28216|Betaproteobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5171720_4	1123267.JONN01000002_gene121	3.278e-123	405.0	COG2267@1|root,COG2267@2|Bacteria,1MVDA@1224|Proteobacteria,2TUDQ@28211|Alphaproteobacteria,2K1MR@204457|Sphingomonadales	204457|Sphingomonadales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HKD2_k127_5171720_13	1537715.JQFJ01000002_gene917	1.881e-64	224.0	COG0816@1|root,COG0816@2|Bacteria,1RDHZ@1224|Proteobacteria,2U98Y@28211|Alphaproteobacteria,2K4GA@204457|Sphingomonadales	204457|Sphingomonadales	L	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA	-	-	-	ko:K07447	-	-	-	-	ko00000,ko01000	-	-	-	RuvX
HKD2_k127_5171720_5	1123267.JONN01000002_gene119	4.312e-119	392.0	COG0540@1|root,COG0540@2|Bacteria,1MWAB@1224|Proteobacteria,2TRHP@28211|Alphaproteobacteria,2K0IH@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the ATCase OTCase family	pyrB	-	2.1.3.2	ko:K00609	ko00240,ko00250,ko01100,map00240,map00250,map01100	M00051	R01397	RC00064,RC02850	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_5171720_10	1123267.JONN01000002_gene118	1.813e-87	307.0	COG3147@1|root,COG5010@1|root,COG3147@2|Bacteria,COG5010@2|Bacteria,1RK9P@1224|Proteobacteria,2U5CI@28211|Alphaproteobacteria,2K119@204457|Sphingomonadales	204457|Sphingomonadales	U	Sporulation related domain	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,TPR_16,TPR_19,TPR_4
HKD2_k127_5171720_15	1123267.JONN01000002_gene117	1.097e-49	185.0	2BWQA@1|root,2ZWJK@2|Bacteria,1N8MW@1224|Proteobacteria,2UGCR@28211|Alphaproteobacteria,2K66S@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5171720_3	1550073.JROH01000012_gene2487	5.901e-129	415.0	COG1192@1|root,COG1192@2|Bacteria,1MWH3@1224|Proteobacteria,2U100@28211|Alphaproteobacteria,2K0JR@204457|Sphingomonadales	204457|Sphingomonadales	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	AAA_31
HKD2_k127_5171720_11	1123267.JONN01000002_gene115	2.11e-72	256.0	COG0790@1|root,COG0790@2|Bacteria,1RJ71@1224|Proteobacteria,2U15P@28211|Alphaproteobacteria,2K032@204457|Sphingomonadales	204457|Sphingomonadales	S	FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	SPOR,Sel1
HKD2_k127_5171720_9	1174684.EBMC1_12781	5.655e-91	308.0	COG0560@1|root,COG0560@2|Bacteria,1MWA3@1224|Proteobacteria,2TSEU@28211|Alphaproteobacteria,2K069@204457|Sphingomonadales	204457|Sphingomonadales	E	phosphoserine phosphatase	serB	-	3.1.3.3	ko:K01079	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R00582	RC00017	ko00000,ko00001,ko00002,ko01000,ko01009	-	-	-	HAD
HKD2_k127_5171720_6	1335760.ASTG01000009_gene264	1.363e-109	365.0	COG0324@1|root,COG0324@2|Bacteria,1MUB2@1224|Proteobacteria,2TR8Z@28211|Alphaproteobacteria,2K0WU@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)	miaA	-	2.5.1.75	ko:K00791	ko00908,ko01100,ko01110,map00908,map01100,map01110	-	R01122	RC02820	ko00000,ko00001,ko01000,ko01006,ko03016	-	-	-	IPPT
HKD2_k127_5171720_7	1123270.ATUR01000002_gene2651	2.428e-94	319.0	COG0059@1|root,COG0059@2|Bacteria,1MV7M@1224|Proteobacteria,2TRXI@28211|Alphaproteobacteria,2JZWR@204457|Sphingomonadales	204457|Sphingomonadales	EH	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate	-	-	-	-	-	-	-	-	-	-	-	-	IlvC,IlvN
HKD2_k127_5171720_8	1123269.NX02_29045	9.591e-93	306.0	COG0221@1|root,COG0221@2|Bacteria,1RA2F@1224|Proteobacteria,2TQZM@28211|Alphaproteobacteria,2K19Z@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions	ppa	-	3.6.1.1	ko:K01507	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	-	-	-	Pyrophosphatase
HKD2_k127_5171720_17	1411123.JQNH01000001_gene2870	1.715e-37	145.0	COG0239@1|root,COG0239@2|Bacteria,1MZNH@1224|Proteobacteria,2UBUP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	D	Important for reducing fluoride concentration in the cell, thus reducing its toxicity	crcB	-	-	ko:K06199	-	-	-	-	ko00000,ko02000	1.A.43.1,1.A.43.2,1.A.43.3	-	-	CRCB
HKD2_k127_5171720_0	1123267.JONN01000001_gene1008	6.93e-251	787.0	COG0323@1|root,COG0323@2|Bacteria,1MV61@1224|Proteobacteria,2TR2M@28211|Alphaproteobacteria,2K2AP@204457|Sphingomonadales	204457|Sphingomonadales	L	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex	mutL	-	-	ko:K03572	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	DNA_mis_repair,HATPase_c_3,MutL_C
HKD2_k127_5171720_1	1144307.PMI04_00238	1.166e-192	605.0	COG1077@1|root,COG1077@2|Bacteria,1MUMW@1224|Proteobacteria,2TTQ2@28211|Alphaproteobacteria,2K10A@204457|Sphingomonadales	204457|Sphingomonadales	D	rod shape-determining protein MreB	mreB	-	-	ko:K03569	-	-	-	-	ko00000,ko02048,ko03036,ko04812	1.A.33.1,9.B.157.1	-	-	MreB_Mbl
HKD2_k127_5171720_12	1123267.JONN01000001_gene1006	1.194e-64	226.0	COG1792@1|root,COG1792@2|Bacteria,1N8ZS@1224|Proteobacteria,2U1FY@28211|Alphaproteobacteria,2K18A@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in formation and maintenance of cell shape	mreC	-	-	ko:K03570	-	-	-	-	ko00000,ko03036	9.B.157.1	-	-	MreC
HKD2_k127_5181918_34	392499.Swit_3384	2.181e-10	63.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,2K2HE@204457|Sphingomonadales	204457|Sphingomonadales	L	COG1961 Site-specific recombinases, DNA invertase Pin homologs	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_5181918_25	517722.AEUE01000001_gene2831	2.417e-49	179.0	COG3824@1|root,COG3824@2|Bacteria,1N18M@1224|Proteobacteria,2UBUK@28211|Alphaproteobacteria,2K6IY@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Zincin_1
HKD2_k127_5181918_24	1123267.JONN01000001_gene2352	1.086e-49	182.0	COG4133@1|root,COG4133@2|Bacteria,1MZPC@1224|Proteobacteria,2TVBT@28211|Alphaproteobacteria,2K5BJ@204457|Sphingomonadales	204457|Sphingomonadales	O	once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system	ccmA	-	3.6.3.41	ko:K02193	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.107	-	-	ABC_tran
HKD2_k127_5181918_18	1123267.JONN01000001_gene2351	1.267e-67	237.0	COG2386@1|root,COG2386@2|Bacteria,1NJB0@1224|Proteobacteria,2TUSG@28211|Alphaproteobacteria,2K43Z@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmB	-	-	ko:K02194	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	CcmB
HKD2_k127_5181918_5	1123267.JONN01000001_gene2350	3.524e-149	475.0	COG1092@1|root,COG1092@2|Bacteria,1QSD4@1224|Proteobacteria,2TUFT@28211|Alphaproteobacteria,2K037@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the methyltransferase superfamily	-	-	2.1.1.191	ko:K06969	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltrans_SAM
HKD2_k127_5181918_9	745310.G432_14290	1.841e-127	421.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TR39@28211|Alphaproteobacteria,2K1F2@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM peptidase M16 domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_5181918_26	1030157.AFMP01000040_gene1399	1.321e-40	157.0	COG3346@1|root,COG3346@2|Bacteria,1RIJQ@1224|Proteobacteria,2UA1G@28211|Alphaproteobacteria,2K34C@204457|Sphingomonadales	204457|Sphingomonadales	S	SURF1-like protein	-	-	-	ko:K14998	-	-	-	-	ko00000,ko03029	3.D.4.8	-	-	SURF1
HKD2_k127_5181918_27	1123267.JONN01000001_gene2347	4.044e-38	150.0	COG5349@1|root,COG5349@2|Bacteria,1N0WU@1224|Proteobacteria,2UCE7@28211|Alphaproteobacteria,2K61Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF983)	-	-	-	-	-	-	-	-	-	-	-	-	DUF983
HKD2_k127_5181918_6	685778.AORL01000022_gene1381	1.83e-140	449.0	COG1845@1|root,COG1845@2|Bacteria,1MUCK@1224|Proteobacteria,2TQWA@28211|Alphaproteobacteria,2JZW3@204457|Sphingomonadales	204457|Sphingomonadales	C	Heme copper-type cytochrome quinol oxidase, subunit 3	ctaE	-	1.9.3.1	ko:K02276	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.4,3.D.4.6	-	-	COX3
HKD2_k127_5181918_21	1174684.EBMC1_14952	3.734e-60	218.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,2K3WU@204457|Sphingomonadales	204457|Sphingomonadales	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD2_k127_5181918_8	1030157.AFMP01000040_gene1404	7.576e-129	420.0	COG0109@1|root,COG0109@2|Bacteria,1MW3S@1224|Proteobacteria,2TRD8@28211|Alphaproteobacteria,2K01V@204457|Sphingomonadales	204457|Sphingomonadales	O	Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group	ctaB	-	2.5.1.141	ko:K02257	ko00190,ko00860,ko01100,ko01110,ko04714,map00190,map00860,map01100,map01110,map04714	M00154	R07411	RC01786	ko00000,ko00001,ko00002,ko01000,ko01006,ko03029	-	-	-	UbiA
HKD2_k127_5181918_22	1121022.ABENE_21520	1.242e-56	204.0	COG0652@1|root,COG0652@2|Bacteria,1RGF5@1224|Proteobacteria,2U980@28211|Alphaproteobacteria,2KGP8@204458|Caulobacterales	204458|Caulobacterales	M	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03767	ko01503,ko04217,map01503,map04217	-	-	-	ko00000,ko00001,ko01000,ko03110,ko04147	-	-	-	Pro_isomerase
HKD2_k127_5181918_3	1449076.JOOE01000002_gene990	2.938e-249	773.0	COG0840@1|root,COG1511@1|root,COG3437@1|root,COG5002@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2KEIX@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
HKD2_k127_5181918_0	1449076.JOOE01000002_gene990	0.0	2231.0	COG0840@1|root,COG1511@1|root,COG3437@1|root,COG5002@1|root,COG0840@2|Bacteria,COG1511@2|Bacteria,COG3437@2|Bacteria,COG5002@2|Bacteria,1R5EN@1224|Proteobacteria,2TWEB@28211|Alphaproteobacteria,2KEIX@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	CHASE3,GAF_2,HATPase_c,HisKA,Response_reg
HKD2_k127_5181918_2	1449076.JOOE01000002_gene989	6.921e-257	809.0	COG3437@1|root,COG4191@1|root,COG3437@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE8,GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_5181918_23	1126627.BAWE01000002_gene23	2.318e-51	207.0	COG1404@1|root,COG2931@1|root,COG4932@1|root,COG1404@2|Bacteria,COG2931@2|Bacteria,COG4932@2|Bacteria,1QYHZ@1224|Proteobacteria,2UHT4@28211|Alphaproteobacteria,3K04W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	M	Belongs to the peptidase S8 family	-	-	-	-	-	-	-	-	-	-	-	-	SdrD_B
HKD2_k127_5181918_17	1123267.JONN01000002_gene286	1.578e-70	250.0	COG0457@1|root,COG1716@1|root,COG0457@2|Bacteria,COG1716@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,2K6JI@204457|Sphingomonadales	204457|Sphingomonadales	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2,TPR_8,Trans_reg_C
HKD2_k127_5181918_29	1123267.JONN01000002_gene287	1.74e-32	137.0	COG0758@1|root,COG0758@2|Bacteria,1R9P1@1224|Proteobacteria,2U30Q@28211|Alphaproteobacteria,2K3JF@204457|Sphingomonadales	204457|Sphingomonadales	LU	DNA mediated transformation	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5181918_4	1123267.JONN01000002_gene288	2.787e-174	567.0	COG0515@1|root,COG0515@2|Bacteria,1PJRR@1224|Proteobacteria,2VF85@28211|Alphaproteobacteria,2KDYZ@204457|Sphingomonadales	204457|Sphingomonadales	KLT	Protein tyrosine kinase	-	-	-	-	-	-	-	-	-	-	-	-	Pkinase
HKD2_k127_5181918_19	1123267.JONN01000002_gene289	1.274e-62	226.0	COG0631@1|root,COG0631@2|Bacteria,1R7UF@1224|Proteobacteria,2U450@28211|Alphaproteobacteria,2K4T7@204457|Sphingomonadales	204457|Sphingomonadales	T	Serine/threonine phosphatases, family 2C, catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	PP2C_2
HKD2_k127_5181918_1	1123267.JONN01000001_gene2339	0.0	1002.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,2K034@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B	ctaD	-	1.9.3.1	ko:K02274	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.3,3.D.4.4,3.D.4.6	-	-	COX1
HKD2_k127_5181918_11	1123267.JONN01000001_gene2338	2.715e-123	405.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2TRK6@28211|Alphaproteobacteria,2K00C@204457|Sphingomonadales	204457|Sphingomonadales	C	Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B)	ctaC	-	1.9.3.1	ko:K02275	ko00190,ko01100,map00190,map01100	M00155	R00081	RC00016	ko00000,ko00001,ko00002,ko01000	3.D.4.2,3.D.4.4,3.D.4.6	-	-	COX2,COX2_TM
HKD2_k127_5181918_15	1123267.JONN01000001_gene2337	1.089e-87	299.0	COG0461@1|root,COG0461@2|Bacteria,1RIC5@1224|Proteobacteria,2TUX2@28211|Alphaproteobacteria,2K1QD@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)	pyrE	-	2.4.2.10	ko:K00762	ko00240,ko01100,map00240,map01100	M00051	R01870	RC00611	ko00000,ko00001,ko00002,ko01000	-	-	-	Pribosyltran
HKD2_k127_5181918_10	1030157.AFMP01000040_gene1410	2.704e-126	408.0	COG0854@1|root,COG0854@2|Bacteria,1MU9W@1224|Proteobacteria,2TTTF@28211|Alphaproteobacteria,2K0T4@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate	pdxJ	-	2.6.99.2	ko:K03474	ko00750,ko01100,map00750,map01100	M00124	R05838	RC01476	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxJ
HKD2_k127_5181918_20	1096930.L284_10660	2.344e-61	219.0	COG0736@1|root,COG0736@2|Bacteria,1MZBF@1224|Proteobacteria,2U77S@28211|Alphaproteobacteria,2K4ID@204457|Sphingomonadales	204457|Sphingomonadales	I	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein	acpS	-	2.7.8.7	ko:K00997	ko00770,map00770	-	R01625	RC00002	ko00000,ko00001,ko01000	-	-	-	ACPS
HKD2_k127_5181918_12	1123267.JONN01000001_gene2334	4.649e-121	394.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2K1V9@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_5181918_13	1123267.JONN01000001_gene2333	2.188e-118	392.0	COG0628@1|root,COG0628@2|Bacteria,1MW0B@1224|Proteobacteria,2TQSH@28211|Alphaproteobacteria,2K0XW@204457|Sphingomonadales	204457|Sphingomonadales	S	permease	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_5181918_31	1123267.JONN01000001_gene2332	5.043e-31	128.0	COG0545@1|root,COG0545@2|Bacteria,1RDA1@1224|Proteobacteria,2U9XK@28211|Alphaproteobacteria,2K4Y5@204457|Sphingomonadales	204457|Sphingomonadales	O	Peptidyl-prolyl cis-trans	-	-	5.2.1.8	ko:K03772	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	FKBP_C,FKBP_N
HKD2_k127_5181918_32	1123267.JONN01000001_gene2331	9.203e-28	113.0	COG0828@1|root,COG0828@2|Bacteria,1MZA1@1224|Proteobacteria,2UC58@28211|Alphaproteobacteria,2K5X3@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bS21 family	rpsU	-	-	ko:K02970	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S21
HKD2_k127_5181918_16	1123267.JONN01000001_gene2330	8.895e-77	263.0	COG1376@1|root,COG1376@2|Bacteria,1RKB2@1224|Proteobacteria,2UAA8@28211|Alphaproteobacteria,2K4DR@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	YkuD_2
HKD2_k127_5181918_7	1123267.JONN01000001_gene2329	2.637e-139	458.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	YkuD
HKD2_k127_5181918_28	1123267.JONN01000001_gene2324	5.465e-34	132.0	29188@1|root,2ZNVC@2|Bacteria,1NM5D@1224|Proteobacteria,2UMZG@28211|Alphaproteobacteria,2K7SH@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5181918_14	1123267.JONN01000001_gene2323	2.529e-112	372.0	COG0652@1|root,COG0652@2|Bacteria,1QCY4@1224|Proteobacteria,2U56N@28211|Alphaproteobacteria,2K25P@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
HKD2_k127_5181918_33	1123267.JONN01000001_gene2322	2.793e-21	99.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2TVIF@28211|Alphaproteobacteria,2K0X5@204457|Sphingomonadales	204457|Sphingomonadales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD2_k127_5184055_7	1123267.JONN01000001_gene1985	1.971e-143	464.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_5184055_30	1123267.JONN01000001_gene1606	1.28e-58	209.0	COG0225@1|root,COG0225@2|Bacteria,1NC84@1224|Proteobacteria,2TTDD@28211|Alphaproteobacteria,2K3XP@204457|Sphingomonadales	204457|Sphingomonadales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA_1	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_5184055_14	1040989.AWZU01000007_gene740	3.984e-93	325.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,3JW86@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Membrane-associated sensor, integral membrane domain	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE4
HKD2_k127_5184055_0	1123267.JONN01000001_gene1816	0.0	1148.0	COG3605@1|root,COG3605@2|Bacteria,1QTTV@1224|Proteobacteria,2TR3Z@28211|Alphaproteobacteria,2K17Q@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the PEP-utilizing enzyme family	ptsP	-	2.7.3.9	ko:K08484	ko02060,map02060	-	-	-	ko00000,ko00001,ko01000,ko02000	-	-	-	GAF_2,PEP-utilisers_N,PEP-utilizers,PEP-utilizers_C
HKD2_k127_5184055_23	1123267.JONN01000001_gene1815	1.866e-72	253.0	COG1426@1|root,COG1426@2|Bacteria,1ND8D@1224|Proteobacteria,2UB49@28211|Alphaproteobacteria,2K57P@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4115)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4115,HTH_25
HKD2_k127_5184055_22	1123267.JONN01000001_gene1814	7.359e-76	274.0	COG1729@1|root,COG1729@2|Bacteria,1R8C4@1224|Proteobacteria,2VBNQ@28211|Alphaproteobacteria,2K0FK@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_6,TolA_bind_tri
HKD2_k127_5184055_21	685778.AORL01000004_gene3516	1.546e-77	271.0	COG0037@1|root,COG0037@2|Bacteria,1MU85@1224|Proteobacteria,2TRK1@28211|Alphaproteobacteria,2K3YA@204457|Sphingomonadales	204457|Sphingomonadales	D	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine	tilS	-	6.3.4.19	ko:K04075	-	-	R09597	RC02633,RC02634	ko00000,ko01000,ko03016	-	-	-	ATP_bind_3
HKD2_k127_5184055_2	1123267.JONN01000001_gene1811	0.0	1078.0	COG0465@1|root,COG0465@2|Bacteria,1MU6J@1224|Proteobacteria,2TSYQ@28211|Alphaproteobacteria,2K1U5@204457|Sphingomonadales	204457|Sphingomonadales	O	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins	ftsH	-	-	ko:K03798	-	M00742	-	-	ko00000,ko00002,ko01000,ko01002,ko03110	-	-	-	AAA,FtsH_ext,Peptidase_M41
HKD2_k127_5184055_15	1122612.AUBA01000008_gene2217	2.138e-91	312.0	COG1566@1|root,COG1566@2|Bacteria,1R50C@1224|Proteobacteria,2TUCN@28211|Alphaproteobacteria,2K0QD@204457|Sphingomonadales	204457|Sphingomonadales	V	Protein of unknown function (DUF3667)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3667
HKD2_k127_5184055_19	1449076.JOOE01000004_gene51	4.054e-83	281.0	COG1057@1|root,COG1057@2|Bacteria,1RD0J@1224|Proteobacteria,2U6ZC@28211|Alphaproteobacteria,2K3WB@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)	nadD	-	2.7.7.18	ko:K00969	ko00760,ko01100,map00760,map01100	M00115	R00137,R03005	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_5184055_31	1219049.SP5_016_00540	4.495e-51	187.0	COG0799@1|root,COG0799@2|Bacteria,1MZEF@1224|Proteobacteria,2UBSV@28211|Alphaproteobacteria,2K55D@204457|Sphingomonadales	204457|Sphingomonadales	J	Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation	rsfS	-	-	ko:K09710	-	-	-	-	ko00000,ko03009	-	-	-	RsfS
HKD2_k127_5184055_12	1123267.JONN01000001_gene1812	5.643e-98	327.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,2UBDH@28211|Alphaproteobacteria,2K2BR@204457|Sphingomonadales	204457|Sphingomonadales	V	beta-lactamase	-	-	3.5.2.6	ko:K17836	ko00311,ko01130,ko01501,map00311,map01130,map01501	M00627,M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000,ko01504	-	-	-	Beta-lactamase2,Peptidase_S13
HKD2_k127_5184055_29	452662.SJA_C1-02550	1.109e-61	214.0	COG1576@1|root,COG1576@2|Bacteria,1R9Z2@1224|Proteobacteria,2U95Q@28211|Alphaproteobacteria,2K4F0@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA	rlmH	-	2.1.1.177	ko:K00783	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SPOUT_MTase
HKD2_k127_5184055_34	392499.Swit_2546	9.615e-49	189.0	COG4942@1|root,COG4942@2|Bacteria,1MY3E@1224|Proteobacteria,2TUSP@28211|Alphaproteobacteria,2K22Y@204457|Sphingomonadales	204457|Sphingomonadales	D	Membrane-bound metallopeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_5184055_5	1123267.JONN01000001_gene1803	5.9e-209	661.0	COG0793@1|root,COG0793@2|Bacteria,1MU39@1224|Proteobacteria,2TRW2@28211|Alphaproteobacteria,2K0TK@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S41A family	ctpA	-	3.4.21.102	ko:K03797	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	PDZ_2,Peptidase_S41
HKD2_k127_5184055_35	1030157.AFMP01000062_gene3502	5.759e-47	174.0	COG1495@1|root,COG1495@2|Bacteria,1N89I@1224|Proteobacteria,2UF49@28211|Alphaproteobacteria,2K59V@204457|Sphingomonadales	204457|Sphingomonadales	O	Disulfide bond formation protein	-	-	-	-	-	-	-	-	-	-	-	-	DsbB
HKD2_k127_5184055_24	1123267.JONN01000001_gene1801	1.181e-70	243.0	COG2941@1|root,COG2941@2|Bacteria,1RAK4@1224|Proteobacteria,2U85I@28211|Alphaproteobacteria,2K46W@204457|Sphingomonadales	204457|Sphingomonadales	H	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol	coq7	-	-	ko:K06134	ko00130,ko01100,ko01110,map00130,map01100,map01110	M00128	R04984,R08775	RC01254	ko00000,ko00001,ko00002,ko01000	-	-	-	COQ7
HKD2_k127_5184055_43	1123267.JONN01000001_gene1800	3.43e-28	119.0	2BJB4@1|root,3186Q@2|Bacteria,1NG3X@1224|Proteobacteria,2UG56@28211|Alphaproteobacteria,2K6GS@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5184055_3	685778.AORL01000021_gene696	8.239e-314	972.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria,2K0TJ@204457|Sphingomonadales	204457|Sphingomonadales	S	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain	-	-	-	ko:K06978	-	-	-	-	ko00000	-	-	-	PepX_C,Peptidase_S15
HKD2_k127_5184055_4	1112214.AHIS01000061_gene2802	3.111e-210	659.0	COG4277@1|root,COG4277@2|Bacteria,1MVCV@1224|Proteobacteria,2TT5U@28211|Alphaproteobacteria,2K0AV@204457|Sphingomonadales	204457|Sphingomonadales	S	DNA-binding protein with the helix-hairpin-helix motif	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5184055_18	13689.BV96_00063	8.818e-86	289.0	COG3047@1|root,COG3047@2|Bacteria,1NUZJ@1224|Proteobacteria,2TRGI@28211|Alphaproteobacteria,2K2CV@204457|Sphingomonadales	204457|Sphingomonadales	M	OmpW family	-	-	-	ko:K07275	-	-	-	-	ko00000	-	-	-	OmpW
HKD2_k127_5184055_6	1112214.AHIS01000061_gene2803	1.206e-194	617.0	COG1573@1|root,COG1573@2|Bacteria,1MW8T@1224|Proteobacteria,2TSAR@28211|Alphaproteobacteria,2K0Y7@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DUF4130,UDG
HKD2_k127_5184055_25	1403819.BATR01000123_gene4356	3.363e-70	248.0	28KDQ@1|root,2ZA05@2|Bacteria,46VJS@74201|Verrucomicrobia	74201|Verrucomicrobia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5184055_27	158500.BV97_03892	5.5e-68	237.0	COG4659@1|root,COG4659@2|Bacteria,1RFGW@1224|Proteobacteria,2U55M@28211|Alphaproteobacteria,2K5DF@204457|Sphingomonadales	204457|Sphingomonadales	C	FMN_bind	-	-	-	-	-	-	-	-	-	-	-	-	FMN_bind
HKD2_k127_5184055_33	1335760.ASTG01000008_gene974	3.422e-50	191.0	COG1477@1|root,COG1477@2|Bacteria,1PE96@1224|Proteobacteria,2VE65@28211|Alphaproteobacteria,2K71H@204457|Sphingomonadales	204457|Sphingomonadales	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	-	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_5184055_42	1335760.ASTG01000008_gene975	2.056e-28	120.0	2DTPH@1|root,33M6B@2|Bacteria,1R3JY@1224|Proteobacteria,2U03T@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5184055_1	1123267.JONN01000001_gene1794	0.0	1090.0	COG1196@1|root,COG1196@2|Bacteria,1MUAQ@1224|Proteobacteria,2TRQG@28211|Alphaproteobacteria,2K02F@204457|Sphingomonadales	204457|Sphingomonadales	D	Required for chromosome condensation and partitioning	smc	-	-	ko:K03529	-	-	-	-	ko00000,ko03036	-	-	-	SMC_N
HKD2_k127_5184055_32	392499.Swit_4693	3.143e-50	193.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,2KCZI@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_5184055_26	1123267.JONN01000001_gene1793	1.39e-68	243.0	COG1651@1|root,COG1651@2|Bacteria,1RFF4@1224|Proteobacteria,2U5BN@28211|Alphaproteobacteria,2KCZI@204457|Sphingomonadales	204457|Sphingomonadales	O	Thioredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Thioredoxin_4
HKD2_k127_5184055_28	1123267.JONN01000001_gene1792	2.282e-62	220.0	COG5389@1|root,COG5389@2|Bacteria,1N82D@1224|Proteobacteria,2UFA9@28211|Alphaproteobacteria,2K4U1@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF721
HKD2_k127_5184055_11	1123267.JONN01000001_gene1791	2.398e-120	396.0	COG1194@1|root,COG1194@2|Bacteria,1MUD4@1224|Proteobacteria,2TQVX@28211|Alphaproteobacteria,2K0ZZ@204457|Sphingomonadales	204457|Sphingomonadales	L	glycosylase	mutY	-	-	ko:K03575	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD,NUDIX_4
HKD2_k127_5184055_13	1123267.JONN01000001_gene1790	2.339e-93	316.0	COG2816@1|root,COG2816@2|Bacteria,1QGCX@1224|Proteobacteria,2TVMG@28211|Alphaproteobacteria,2K1ZX@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the Nudix hydrolase family	-	-	3.6.1.22	ko:K03426	ko00760,ko01100,ko04146,map00760,map01100,map04146	-	R00103,R03004,R11104	RC00002	ko00000,ko00001,ko01000	-	-	-	NUDIX,NUDIX-like,zf-NADH-PPase
HKD2_k127_5184055_20	745310.G432_02635	2.25e-80	274.0	COG3474@1|root,COG3474@2|Bacteria,1RIDN@1224|Proteobacteria,2U142@28211|Alphaproteobacteria,2K42S@204457|Sphingomonadales	204457|Sphingomonadales	C	cytochrome C	-	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD2_k127_5184055_8	1123267.JONN01000001_gene1787	1.417e-133	433.0	COG1611@1|root,COG1611@2|Bacteria,1MU6N@1224|Proteobacteria,2TR90@28211|Alphaproteobacteria,2K00V@204457|Sphingomonadales	204457|Sphingomonadales	S	Rossmann fold nucleotide-binding protein	-	-	3.2.2.10	ko:K06966	ko00230,ko00240,map00230,map00240	-	R00182,R00510	RC00063,RC00318	ko00000,ko00001,ko01000	-	-	-	Lysine_decarbox
HKD2_k127_5184055_10	1123267.JONN01000001_gene1850	3.264e-121	393.0	COG1741@1|root,COG1741@2|Bacteria,1MVSW@1224|Proteobacteria,2TSR6@28211|Alphaproteobacteria,2K0PN@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin
HKD2_k127_5184055_17	1123267.JONN01000001_gene1826	3.488e-86	289.0	COG0122@1|root,COG0122@2|Bacteria,1MX9C@1224|Proteobacteria,2TVJ7@28211|Alphaproteobacteria,2K0I0@204457|Sphingomonadales	204457|Sphingomonadales	L	COG0122 3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase	-	-	3.2.2.21	ko:K01247	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HhH-GPD
HKD2_k127_5184055_9	1123267.JONN01000001_gene1825	1.258e-121	393.0	COG0566@1|root,COG0566@2|Bacteria,1MWCM@1224|Proteobacteria,2TUG7@28211|Alphaproteobacteria,2K163@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	2.1.1.185	ko:K03218	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_5184055_16	1379270.AUXF01000001_gene1925	2.096e-87	304.0	COG3391@1|root,COG3391@2|Bacteria	2|Bacteria	CO	amine dehydrogenase activity	-	-	-	ko:K17285	-	-	-	-	ko00000,ko04147	-	-	-	SBP56,SHD1
HKD2_k127_5184055_37	366602.Caul_2480	1.781e-38	158.0	COG4564@1|root,COG4564@2|Bacteria,1QTY1@1224|Proteobacteria,2TVYD@28211|Alphaproteobacteria,2KJD9@204458|Caulobacterales	204458|Caulobacterales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HisKA_3
HKD2_k127_5184055_46	1219035.NT2_05_02100	7.866e-15	78.0	COG1525@1|root,COG1525@2|Bacteria,1N145@1224|Proteobacteria,2UCUE@28211|Alphaproteobacteria,2K65J@204457|Sphingomonadales	204457|Sphingomonadales	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	Excalibur,SNase
HKD2_k127_5184055_40	745310.G432_04995	4.857e-35	136.0	COG1525@1|root,COG1525@2|Bacteria,1QIYA@1224|Proteobacteria,2UUTU@28211|Alphaproteobacteria,2K7BY@204457|Sphingomonadales	204457|Sphingomonadales	L	Staphylococcal nuclease homologue	-	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD2_k127_5184055_45	426355.Mrad2831_6274	3.164e-23	104.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,1JW27@119045|Methylobacteriaceae	28211|Alphaproteobacteria	K	Ribonuclease B OB domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_5184055_48	555793.WSK_2728	1.796e-09	62.0	29Z78@1|root,30M59@2|Bacteria,1P997@1224|Proteobacteria,2UY8U@28211|Alphaproteobacteria,2K89E@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5184055_38	1096930.L284_01070	5.284e-36	138.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,2KD9P@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	-	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_5184055_47	215803.DB30_7463	7.249e-11	67.0	COG3239@1|root,COG3239@2|Bacteria,1PP7Y@1224|Proteobacteria,42YWN@68525|delta/epsilon subdivisions,2WUKG@28221|Deltaproteobacteria,2YYFI@29|Myxococcales	28221|Deltaproteobacteria	I	Fatty acid desaturase	-	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_5184055_44	1406840.Q763_13330	3.252e-26	113.0	COG3239@1|root,COG3239@2|Bacteria,4NERD@976|Bacteroidetes,1HX6Z@117743|Flavobacteriia,2NUDD@237|Flavobacterium	976|Bacteroidetes	I	fatty acid desaturase	-	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_5184055_50	1123269.NX02_03035	9.89e-07	55.0	2BMNS@1|root,32G80@2|Bacteria,1NMXA@1224|Proteobacteria,2UNGA@28211|Alphaproteobacteria,2K7TQ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF2384
HKD2_k127_5184055_39	1380355.JNIJ01000011_gene815	7.491e-36	140.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria,3JZ7D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
HKD2_k127_5184055_36	1234595.C725_2819	4.173e-41	160.0	COG4233@1|root,COG4233@2|Bacteria,1NF38@1224|Proteobacteria,2TVYG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CO	to be involved in C-type cytochrome biogenesis	-	-	-	-	-	-	-	-	-	-	-	-	DsbC
HKD2_k127_5224244_3	935548.KI912159_gene2058	1.675e-73	278.0	COG3409@1|root,COG4249@1|root,COG3409@2|Bacteria,COG4249@2|Bacteria,1NJ33@1224|Proteobacteria,2UJ8S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Caspase domain	-	-	-	-	-	-	-	-	-	-	-	-	OmpA,Peptidase_C14
HKD2_k127_5224244_4	717785.HYPMC_1508	9.845e-73	252.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,3N8RA@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	K	helix_turn_helix, Lux Regulon	-	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_5224244_2	717785.HYPMC_1509	3.415e-174	565.0	COG3447@1|root,COG4191@1|root,COG3447@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,MASE1
HKD2_k127_5224244_1	717785.HYPMC_1512	1.329e-176	567.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,3N672@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	MU	Outer membrane efflux protein	oprN	-	-	ko:K18300,ko:K19593	-	M00641,M00769	-	-	ko00000,ko00002,ko01504,ko02000	1.B.17,2.A.6.2.34	-	-	OEP
HKD2_k127_5224244_0	670307.HYPDE_29773	5.663e-208	657.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,3N8Q4@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD2_k127_5226878_7	1144307.PMI04_02826	2.106e-10	68.0	COG1403@1|root,COG1403@2|Bacteria,1MZVF@1224|Proteobacteria,2UBUF@28211|Alphaproteobacteria,2K5ZU@204457|Sphingomonadales	204457|Sphingomonadales	V	COG1403 Restriction endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH
HKD2_k127_5226878_8	1379701.JPJC01000060_gene3161	3.359e-05	51.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4,PAS_9,PilZ
HKD2_k127_5226878_5	161528.ED21_19192	2.147e-53	199.0	28N2A@1|root,2ZB84@2|Bacteria,1R8N1@1224|Proteobacteria,2U7C7@28211|Alphaproteobacteria,2K4F8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5226878_3	1090318.ATTI01000001_gene1613	2.786e-120	394.0	COG2175@1|root,COG2175@2|Bacteria,1MWQ6@1224|Proteobacteria,2TQX1@28211|Alphaproteobacteria,2K7RQ@204457|Sphingomonadales	204457|Sphingomonadales	Q	Taurine catabolism dioxygenase TauD, TfdA family	-	-	-	-	-	-	-	-	-	-	-	-	TauD
HKD2_k127_5226878_4	1112214.AHIS01000089_gene922	1.48e-92	315.0	2ASJY@1|root,310VC@2|Bacteria,1QEZ3@1224|Proteobacteria,2UZAI@28211|Alphaproteobacteria,2K8F1@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5226878_0	1123267.JONN01000001_gene1974	0.0	1272.0	COG0556@1|root,COG0556@2|Bacteria,1MUFK@1224|Proteobacteria,2TQSP@28211|Alphaproteobacteria,2K0F9@204457|Sphingomonadales	204457|Sphingomonadales	L	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage	uvrB	-	-	ko:K03702	ko03420,map03420	-	-	-	ko00000,ko00001,ko03400	-	-	-	Helicase_C,ResIII,UVR,UvrB
HKD2_k127_5226878_6	1121123.AUAO01000005_gene1709	3.025e-31	129.0	2C7KN@1|root,336M6@2|Bacteria,1N4WC@1224|Proteobacteria,2UF7X@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5226878_1	450851.PHZ_c2659	4.163e-209	669.0	COG0784@1|root,COG3829@1|root,COG4191@1|root,COG0784@2|Bacteria,COG3829@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2KI05@204458|Caulobacterales	204458|Caulobacterales	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_9,Response_reg
HKD2_k127_5226878_2	1502850.FG91_03741	7.955e-163	526.0	COG0624@1|root,COG0624@2|Bacteria,1MUSU@1224|Proteobacteria,2TTBP@28211|Alphaproteobacteria,2K14S@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase M20	-	-	3.4.17.11	ko:K01295	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	M20_dimer,Peptidase_M20,Peptidase_M28
HKD2_k127_5230799_4	1123267.JONN01000001_gene1999	2.927e-88	300.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TS7X@28211|Alphaproteobacteria,2KEG6@204457|Sphingomonadales	204457|Sphingomonadales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_5230799_2	279238.Saro_2913	5.596e-138	443.0	COG1741@1|root,COG1741@2|Bacteria,1MWIP@1224|Proteobacteria,2TRHR@28211|Alphaproteobacteria,2K10E@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the pirin family	-	-	-	ko:K06911	-	-	-	-	ko00000	-	-	-	Pirin,Pirin_C
HKD2_k127_5230799_0	745310.G432_10140	8.61e-257	827.0	COG4625@1|root,COG4625@2|Bacteria,1N0PT@1224|Proteobacteria,2TTFH@28211|Alphaproteobacteria,2K0XX@204457|Sphingomonadales	204457|Sphingomonadales	EQ	Autotransporter beta-domain	-	-	-	-	-	-	-	-	-	-	-	-	Autotransporter
HKD2_k127_5230799_14	392499.Swit_2333	6.887e-33	131.0	COG0271@1|root,COG0271@2|Bacteria,1MZG5@1224|Proteobacteria,2UF6U@28211|Alphaproteobacteria,2K60E@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the BolA IbaG family	-	-	-	ko:K05527	-	-	-	-	ko00000,ko03000	-	-	-	BolA
HKD2_k127_5230799_10	1123267.JONN01000001_gene2003	1.031e-70	243.0	COG2214@1|root,COG2214@2|Bacteria,1MXTG@1224|Proteobacteria,2TRZH@28211|Alphaproteobacteria,2K4VC@204457|Sphingomonadales	204457|Sphingomonadales	O	molecular chaperone	-	-	-	-	-	-	-	-	-	-	-	-	DnaJ
HKD2_k127_5230799_5	1123267.JONN01000001_gene2004	5.316e-83	281.0	COG0625@1|root,COG0625@2|Bacteria,1PENB@1224|Proteobacteria,2TRVC@28211|Alphaproteobacteria,2K49C@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase, N-terminal domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_5230799_13	1041138.KB890233_gene1819	4.16e-49	183.0	COG0262@1|root,COG0262@2|Bacteria,1R5UU@1224|Proteobacteria,2U45H@28211|Alphaproteobacteria,4B988@82115|Rhizobiaceae	28211|Alphaproteobacteria	H	RibD C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	RibD_C
HKD2_k127_5230799_6	864069.MicloDRAFT_00069550	1.433e-81	276.0	COG3865@1|root,COG3865@2|Bacteria,1N7IY@1224|Proteobacteria,2U993@28211|Alphaproteobacteria,1JUTS@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM 3-demethylubiquinone-9 3-methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	3-dmu-9_3-mt
HKD2_k127_5230799_8	1096930.L284_13620	1.112e-80	279.0	COG3324@1|root,COG3324@2|Bacteria,1R81W@1224|Proteobacteria,2U6BE@28211|Alphaproteobacteria,2K4NC@204457|Sphingomonadales	204457|Sphingomonadales	S	enzyme related to lactoylglutathione lyase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_5230799_7	864069.MicloDRAFT_00069530	1.761e-81	278.0	COG5507@1|root,COG5507@2|Bacteria,1RHC1@1224|Proteobacteria,2UC7A@28211|Alphaproteobacteria,1JY94@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1428)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1428
HKD2_k127_5230799_11	1123267.JONN01000001_gene2010	8.933e-66	231.0	COG0625@1|root,COG0625@2|Bacteria,1NE6Z@1224|Proteobacteria,2TVN6@28211|Alphaproteobacteria,2K4P4@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	-	-	-	-	-	-	-	-	-	-	GST_N
HKD2_k127_5230799_12	1123267.JONN01000001_gene2011	2.294e-58	206.0	COG3607@1|root,COG3607@2|Bacteria,1RH1T@1224|Proteobacteria,2U7DZ@28211|Alphaproteobacteria,2K69I@204457|Sphingomonadales	204457|Sphingomonadales	S	Lactoylglutathione lyase	-	-	-	ko:K07032	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_5230799_9	187303.BN69_2951	1.234e-75	259.0	COG1733@1|root,COG1733@2|Bacteria,1MZ6N@1224|Proteobacteria,2UC19@28211|Alphaproteobacteria,370HX@31993|Methylocystaceae	28211|Alphaproteobacteria	K	HxlR-like helix-turn-helix	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_5230799_1	392499.Swit_2331	6.68e-194	607.0	COG0714@1|root,COG0714@2|Bacteria,1MXIW@1224|Proteobacteria,2TS1Z@28211|Alphaproteobacteria,2K0S6@204457|Sphingomonadales	204457|Sphingomonadales	S	Aerobic cobaltochelatase subunit CobS	-	-	6.6.1.2	ko:K09882	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	AAA_5,CbbQ_C,CobS_N
HKD2_k127_5230799_3	1122137.AQXF01000002_gene429	1.15e-133	443.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8,Reprolysin_4
HKD2_k127_5286156_1	1123267.JONN01000002_gene196	2.645e-106	360.0	COG4529@1|root,COG4529@2|Bacteria,1MU3U@1224|Proteobacteria,2TUBM@28211|Alphaproteobacteria,2K079@204457|Sphingomonadales	204457|Sphingomonadales	S	FAD-NAD(P)-binding	-	-	-	-	-	-	-	-	-	-	-	-	NAD_binding_9
HKD2_k127_5286156_0	1123267.JONN01000002_gene197	5.366e-110	359.0	COG0302@1|root,COG0302@2|Bacteria,1MY3N@1224|Proteobacteria,2TSZI@28211|Alphaproteobacteria,2K0QV@204457|Sphingomonadales	204457|Sphingomonadales	H	GTP cyclohydrolase	folE	-	3.5.4.16	ko:K01495	ko00790,ko01100,map00790,map01100	M00126,M00841,M00842,M00843	R00428,R04639,R05046,R05048	RC00263,RC00294,RC00323,RC00945,RC01188	ko00000,ko00001,ko00002,ko01000	-	-	-	GTP_cyclohydroI
HKD2_k127_5286156_2	1123267.JONN01000001_gene574	3.265e-42	158.0	COG1633@1|root,COG1633@2|Bacteria,1RJUG@1224|Proteobacteria,2UATR@28211|Alphaproteobacteria,2K5EA@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF2383)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2383
HKD2_k127_5331816_56	450851.PHZ_c3511	1.716e-51	190.0	COG2207@1|root,COG2207@2|Bacteria,1MZEA@1224|Proteobacteria,2UDBY@28211|Alphaproteobacteria,2KIZ0@204458|Caulobacterales	204458|Caulobacterales	K	helix_turn_helix, arabinose operon control protein	-	-	-	-	-	-	-	-	-	-	-	-	HTH_18
HKD2_k127_5331816_21	1123267.JONN01000001_gene1568	2.388e-139	452.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2K08Y@204457|Sphingomonadales	204457|Sphingomonadales	M	glycosyl transferase group 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HKD2_k127_5331816_22	1123267.JONN01000001_gene1567	4.929e-139	447.0	COG2908@1|root,COG2908@2|Bacteria,1MVKD@1224|Proteobacteria,2TSEB@28211|Alphaproteobacteria,2K0Q8@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos,Metallophos_2
HKD2_k127_5331816_59	318996.AXAZ01000001_gene4664	1.012e-36	149.0	COG3125@1|root,COG3125@2|Bacteria,1RHE5@1224|Proteobacteria,2U67R@28211|Alphaproteobacteria,3JYQ2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Prokaryotic Cytochrome C oxidase subunit IV	cyoD	-	-	ko:K02300	ko00190,ko01100,map00190,map01100	M00417	-	-	ko00000,ko00001,ko00002	3.D.4.5	-	-	COX4_pro
HKD2_k127_5331816_42	765698.Mesci_6325	1.653e-76	261.0	COG1845@1|root,COG1845@2|Bacteria,1RBJC@1224|Proteobacteria,2VG3K@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	oxidase subunit	-	-	-	ko:K02299	ko00190,ko01100,map00190,map01100	M00417	-	-	ko00000,ko00001,ko00002	3.D.4.5	-	-	COX3
HKD2_k127_5331816_3	231434.JQJH01000001_gene1705	3.231e-315	976.0	COG0843@1|root,COG0843@2|Bacteria,1MU7S@1224|Proteobacteria,2TQP1@28211|Alphaproteobacteria,3NBX6@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome C and Quinol oxidase polypeptide I	cyoB	GO:0003674,GO:0003824,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006091,GO:0006810,GO:0006811,GO:0006812,GO:0008150,GO:0008152,GO:0009060,GO:0009486,GO:0009987,GO:0015002,GO:0015672,GO:0015980,GO:0015988,GO:0015990,GO:0016020,GO:0016021,GO:0016491,GO:0022900,GO:0022904,GO:0031224,GO:0031226,GO:0034220,GO:0044237,GO:0044425,GO:0044459,GO:0044464,GO:0045333,GO:0051179,GO:0051234,GO:0055085,GO:0055114,GO:0071944,GO:0098655,GO:0098660,GO:0098662,GO:1902600	1.10.3.10	ko:K02298	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX1
HKD2_k127_5331816_32	876269.ARWA01000001_gene1462	1.253e-102	344.0	COG1622@1|root,COG1622@2|Bacteria,1MWHZ@1224|Proteobacteria,2U0IR@28211|Alphaproteobacteria,3NBY1@45404|Beijerinckiaceae	28211|Alphaproteobacteria	C	Cytochrome C oxidase subunit II, periplasmic domain	cyoA	-	1.10.3.10	ko:K02297	ko00190,ko01100,map00190,map01100	M00417	R11335	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.4.5	-	-	COX2,COX_ARM
HKD2_k127_5331816_62	1126627.BAWE01000004_gene4114	5.328e-32	132.0	COG3467@1|root,COG3467@2|Bacteria,1RAZD@1224|Proteobacteria,2TXIF@28211|Alphaproteobacteria,3K6W8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_5331816_40	627192.SLG_38420	3.119e-79	270.0	COG4566@1|root,COG4566@2|Bacteria,1N6WR@1224|Proteobacteria,2TUND@28211|Alphaproteobacteria,2K16W@204457|Sphingomonadales	204457|Sphingomonadales	K	part of global network that controls expression of aerobic respiratory terminal oxidases and carbon and nitrogen metabolic enzymes	-	-	-	ko:K14987	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_5331816_24	1030157.AFMP01000036_gene2542	1.591e-134	439.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TR8X@28211|Alphaproteobacteria,2K0ZS@204457|Sphingomonadales	204457|Sphingomonadales	T	nitrogen fixation sensor protein fixL	-	-	2.7.13.3	ko:K14986	ko02020,map02020	M00524	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,HATPase_c,HisKA,PAS
HKD2_k127_5331816_67	414684.RC1_1955	4.664e-12	71.0	2D1BA@1|root,32TAA@2|Bacteria,1RJQD@1224|Proteobacteria,2U780@28211|Alphaproteobacteria,2JTH2@204441|Rhodospirillales	204441|Rhodospirillales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_36	1120705.FG95_00354	9.908e-94	312.0	COG0580@1|root,COG0580@2|Bacteria,1PPTN@1224|Proteobacteria,2TW8M@28211|Alphaproteobacteria,2K1WK@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the MIP aquaporin (TC 1.A.8) family	-	-	-	-	-	-	-	-	-	-	-	-	MIP
HKD2_k127_5331816_51	1123267.JONN01000002_gene188	8.239e-65	224.0	COG0745@1|root,COG0745@2|Bacteria,1QUSA@1224|Proteobacteria,2TW5G@28211|Alphaproteobacteria,2K5A5@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	ko:K13589	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg
HKD2_k127_5331816_41	1123267.JONN01000002_gene187	3.704e-79	273.0	COG3741@1|root,COG3741@2|Bacteria,1MY4D@1224|Proteobacteria,2TUPZ@28211|Alphaproteobacteria,2K41R@204457|Sphingomonadales	204457|Sphingomonadales	E	N-formylglutamate amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	FGase
HKD2_k127_5331816_27	1123267.JONN01000002_gene186	8.792e-115	377.0	2D4T1@1|root,32THI@2|Bacteria,1N892@1224|Proteobacteria,2TWF7@28211|Alphaproteobacteria,2KEER@204457|Sphingomonadales	204457|Sphingomonadales	S	PFAM SapC family protein	-	-	-	-	-	-	-	-	-	-	-	-	SapC
HKD2_k127_5331816_60	1123267.JONN01000002_gene185	2.103e-35	139.0	2AM8F@1|root,31C39@2|Bacteria,1N008@1224|Proteobacteria,2UCNF@28211|Alphaproteobacteria,2K748@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_10	1123267.JONN01000002_gene184	5.272e-194	614.0	COG0513@1|root,COG0513@2|Bacteria,1MU49@1224|Proteobacteria,2TR6Q@28211|Alphaproteobacteria,2K0CY@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the DEAD box helicase family	-	-	-	-	-	-	-	-	-	-	-	-	DEAD,Helicase_C
HKD2_k127_5331816_19	1380391.JIAS01000001_gene2713	1.681e-145	466.0	COG0625@1|root,COG0625@2|Bacteria,1MUN3@1224|Proteobacteria,2TTDF@28211|Alphaproteobacteria,2JQ9R@204441|Rhodospirillales	204441|Rhodospirillales	O	Glutathione S-transferase, C-terminal domain	-	-	-	ko:K11209	-	-	-	-	ko00000,ko01000	-	-	-	GST_C,GST_C_2,GST_N
HKD2_k127_5331816_11	1123267.JONN01000002_gene179	6.163e-194	613.0	COG0343@1|root,COG0343@2|Bacteria,1MUCA@1224|Proteobacteria,2TR87@28211|Alphaproteobacteria,2K0II@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine)	tgt	-	2.4.2.29	ko:K00773	-	-	R03789,R10209	RC00063	ko00000,ko01000,ko03016	-	-	-	TGT
HKD2_k127_5331816_14	392499.Swit_0025	3.089e-169	537.0	COG0809@1|root,COG0809@2|Bacteria,1MUH3@1224|Proteobacteria,2TS0D@28211|Alphaproteobacteria,2K0G0@204457|Sphingomonadales	204457|Sphingomonadales	J	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)	queA	-	2.4.99.17	ko:K07568	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Queuosine_synth
HKD2_k127_5331816_53	1123267.JONN01000002_gene169	3.604e-62	220.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,2KCVY@204457|Sphingomonadales	204457|Sphingomonadales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	-	-	-	-	-	-	-	-	-	-	Pro_isomerase
HKD2_k127_5331816_44	1112212.JH584235_gene1501	4.873e-74	252.0	COG0669@1|root,COG0669@2|Bacteria,1RD9F@1224|Proteobacteria,2U74H@28211|Alphaproteobacteria,2K1RJ@204457|Sphingomonadales	204457|Sphingomonadales	H	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate	coaD	-	2.7.7.3	ko:K00954	ko00770,ko01100,map00770,map01100	M00120	R03035	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_like
HKD2_k127_5331816_26	1123267.JONN01000002_gene167	1.081e-125	408.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,2K19H@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_5331816_63	1123267.JONN01000002_gene166	1.267e-27	113.0	COG1722@1|root,COG1722@2|Bacteria,1PTYQ@1224|Proteobacteria,2UFD6@28211|Alphaproteobacteria,2K6WZ@204457|Sphingomonadales	204457|Sphingomonadales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseB	-	3.1.11.6	ko:K03602	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_S
HKD2_k127_5331816_28	1123267.JONN01000002_gene165	7.551e-113	368.0	COG3820@1|root,COG3820@2|Bacteria,1MVR2@1224|Proteobacteria,2TT8Z@28211|Alphaproteobacteria,2K0D3@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09987	-	-	-	-	ko00000	-	-	-	DUF1013
HKD2_k127_5331816_20	1090320.KB900605_gene720	1.765e-142	459.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TR1J@28211|Alphaproteobacteria,2K115@204457|Sphingomonadales	204457|Sphingomonadales	C	NADPH quinone	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_5331816_68	1112214.AHIS01000061_gene2824	6.789e-12	70.0	COG5509@1|root,COG5509@2|Bacteria,1NG8P@1224|Proteobacteria,2UJB2@28211|Alphaproteobacteria,2K7YT@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1192)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1192
HKD2_k127_5331816_1	264203.ZMO0405	0.0	1204.0	COG0542@1|root,COG0542@2|Bacteria,1MV8B@1224|Proteobacteria,2TQUZ@28211|Alphaproteobacteria,2K0MN@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the ClpA ClpB family	clpA	-	-	ko:K03694	-	-	-	-	ko00000,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_5331816_61	1123267.JONN01000002_gene159	2.268e-32	132.0	2B9KF@1|root,322YP@2|Bacteria,1P8XS@1224|Proteobacteria,2UX7H@28211|Alphaproteobacteria,2K64E@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_48	1449049.JONW01000006_gene2912	9.941e-69	244.0	COG0053@1|root,COG0053@2|Bacteria,1MVH8@1224|Proteobacteria,2TVQV@28211|Alphaproteobacteria,2KI8Y@204458|Caulobacterales	204458|Caulobacterales	P	Cation efflux family	-	-	-	-	-	-	-	-	-	-	-	-	Cation_efflux,ZT_dimer
HKD2_k127_5331816_50	1449049.JONW01000005_gene1121	3.422e-65	237.0	COG4313@1|root,COG4313@2|Bacteria,1N5CH@1224|Proteobacteria,2UDDM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein involved in meta-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_5331816_5	745310.G432_02550	1.435e-291	910.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,1MWGR@1224|Proteobacteria,2TRTE@28211|Alphaproteobacteria,2K0PD@204457|Sphingomonadales	204457|Sphingomonadales	EU	Prolyl oligopeptidase family	-	-	-	-	-	-	-	-	-	-	-	-	PD40,Peptidase_S9
HKD2_k127_5331816_6	685778.AORL01000004_gene3475	4.828e-233	733.0	COG2234@1|root,COG2234@2|Bacteria,1MV86@1224|Proteobacteria,2TVJ5@28211|Alphaproteobacteria,2K04D@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD2_k127_5331816_38	1174684.EBMC1_12315	3.059e-82	279.0	COG0625@1|root,COG0625@2|Bacteria,1RA05@1224|Proteobacteria,2TS58@28211|Alphaproteobacteria,2K1M0@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutathione S-transferase	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N,GST_N_3
HKD2_k127_5331816_35	745310.G432_02555	1.08e-94	318.0	COG0412@1|root,COG0412@2|Bacteria,1MW7S@1224|Proteobacteria,2TTPH@28211|Alphaproteobacteria,2K1JX@204457|Sphingomonadales	204457|Sphingomonadales	Q	dienelactone hydrolase	-	-	3.1.1.45	ko:K01061	ko00361,ko00364,ko00623,ko01100,ko01110,ko01120,ko01130,map00361,map00364,map00623,map01100,map01110,map01120,map01130	-	R03893,R05510,R05511,R06835,R06838,R08120,R08121,R09136,R09220,R09222	RC01018,RC01906,RC01907,RC02441,RC02467,RC02468,RC02674,RC02675,RC02686	ko00000,ko00001,ko01000	-	-	-	DLH
HKD2_k127_5331816_52	1442599.JAAN01000010_gene314	1.303e-64	227.0	2DMBA@1|root,32GFI@2|Bacteria,1RM38@1224|Proteobacteria,1SNFE@1236|Gammaproteobacteria,1X66M@135614|Xanthomonadales	135614|Xanthomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_37	1090320.KB900605_gene1528	1.466e-91	308.0	COG0670@1|root,COG0670@2|Bacteria,1MU69@1224|Proteobacteria,2TRSF@28211|Alphaproteobacteria,2K14K@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the BI1 family	-	-	-	ko:K06890	-	-	-	-	ko00000	-	-	-	Bax1-I
HKD2_k127_5331816_57	1082933.MEA186_09355	9.66e-50	191.0	COG1215@1|root,COG1215@2|Bacteria	2|Bacteria	M	transferase activity, transferring glycosyl groups	-	-	-	-	-	-	-	-	-	-	-	-	Glycos_transf_2
HKD2_k127_5331816_34	161528.ED21_20789	5.433e-101	340.0	COG0639@1|root,COG0639@2|Bacteria,1QEIM@1224|Proteobacteria,2UUEK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Protein phosphatase 2A homologues, catalytic domain.	-	-	-	-	-	-	-	-	-	-	-	-	Metallophos
HKD2_k127_5331816_45	291985.CCSI01000007_gene460	5.518e-74	261.0	28M5H@1|root,2ZAJ9@2|Bacteria,1RJY2@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_39	1123267.JONN01000001_gene460	4.926e-81	277.0	COG2518@1|root,COG2518@2|Bacteria,1QYXY@1224|Proteobacteria,2TY17@28211|Alphaproteobacteria,2KEKI@204457|Sphingomonadales	204457|Sphingomonadales	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25,Methyltransf_31
HKD2_k127_5331816_9	1123267.JONN01000001_gene459	1.258e-206	646.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2TR9V@28211|Alphaproteobacteria,2K0B2@204457|Sphingomonadales	204457|Sphingomonadales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_5331816_0	1123267.JONN01000001_gene458	0.0	1207.0	COG5009@1|root,COG5009@2|Bacteria,1MU5A@1224|Proteobacteria,2USBB@28211|Alphaproteobacteria,2K0P9@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	PCB_OB,Transgly,Transpeptidase
HKD2_k127_5331816_46	1123267.JONN01000001_gene457	6.548e-70	246.0	COG0860@1|root,COG0860@2|Bacteria,1MUQK@1224|Proteobacteria,2U0K2@28211|Alphaproteobacteria,2K2BU@204457|Sphingomonadales	204457|Sphingomonadales	M	N-acetylmuramoyl-L-alanine amidase	-	-	3.5.1.28	ko:K01448	ko01503,map01503	M00727	R04112	RC00064,RC00141	ko00000,ko00001,ko00002,ko01000,ko01011,ko03036	-	-	-	AMIN,Amidase_3
HKD2_k127_5331816_33	1219035.NT2_05_02660	2.413e-101	339.0	COG0837@1|root,COG0837@2|Bacteria,1MVFI@1224|Proteobacteria,2U0CA@28211|Alphaproteobacteria,2K0NK@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the bacterial glucokinase family	glk	-	2.7.1.2	ko:K00845	ko00010,ko00052,ko00500,ko00520,ko00521,ko00524,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00052,map00500,map00520,map00521,map00524,map01100,map01110,map01120,map01130,map01200	M00001,M00549	R00299,R01600,R01786	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glucokinase
HKD2_k127_5331816_17	317655.Sala_0114	1.89e-159	507.0	COG1023@1|root,COG1023@2|Bacteria,1QU14@1224|Proteobacteria,2TT6S@28211|Alphaproteobacteria,2K14W@204457|Sphingomonadales	204457|Sphingomonadales	G	6-phosphogluconate dehydrogenase	-	-	1.1.1.343,1.1.1.44	ko:K00033	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,map00030,map00480,map01100,map01110,map01120,map01130,map01200	M00004,M00006	R01528,R10221	RC00001,RC00539	ko00000,ko00001,ko00002,ko01000	-	-	-	6PGD,NAD_binding_2
HKD2_k127_5331816_8	1054213.HMPREF9946_03922	7.728e-219	688.0	COG0364@1|root,COG0364@2|Bacteria,1MUN0@1224|Proteobacteria,2TQXA@28211|Alphaproteobacteria,2JQ25@204441|Rhodospirillales	204441|Rhodospirillales	G	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone	zwf	-	1.1.1.363,1.1.1.49	ko:K00036	ko00030,ko00480,ko01100,ko01110,ko01120,ko01130,ko01200,ko05230,map00030,map00480,map01100,map01110,map01120,map01130,map01200,map05230	M00004,M00006,M00008	R00835,R02736,R10907	RC00001,RC00066	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	G6PD_C,G6PD_N
HKD2_k127_5331816_2	1123267.JONN01000001_gene456	1.023e-317	995.0	COG1530@1|root,COG1530@2|Bacteria,1MV65@1224|Proteobacteria,2TRX2@28211|Alphaproteobacteria,2K00N@204457|Sphingomonadales	204457|Sphingomonadales	J	Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs	rne	-	3.1.26.12	ko:K08300	ko03018,map03018	M00394	-	-	ko00000,ko00001,ko00002,ko01000,ko03009,ko03019	-	-	-	RNase_E_G,S1
HKD2_k127_5331816_12	1123267.JONN01000001_gene1701	1.56e-179	574.0	COG4783@1|root,COG4783@2|Bacteria,1MVFV@1224|Proteobacteria,2TTV2@28211|Alphaproteobacteria,2K0E5@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase M48	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M48,TPR_16
HKD2_k127_5331816_43	1123267.JONN01000001_gene1702	3.826e-75	266.0	COG1651@1|root,COG1651@2|Bacteria,1MY3H@1224|Proteobacteria,2TTXR@28211|Alphaproteobacteria,2K3ZK@204457|Sphingomonadales	204457|Sphingomonadales	O	Protein-disulfide isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DSBA,Thioredoxin_4
HKD2_k127_5331816_16	1112212.JH584235_gene2652	8.832e-163	522.0	COG1914@1|root,COG1914@2|Bacteria,1MW6X@1224|Proteobacteria,2TRNM@28211|Alphaproteobacteria,2K3P4@204457|Sphingomonadales	204457|Sphingomonadales	P	Natural resistance-associated macrophage protein	-	-	-	-	-	-	-	-	-	-	-	-	Nramp
HKD2_k127_5331816_30	1123267.JONN01000001_gene1709	1.149e-108	357.0	COG0293@1|root,COG0293@2|Bacteria,1MW1C@1224|Proteobacteria,2TSBW@28211|Alphaproteobacteria,2K02A@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit	ftsJ	-	2.1.1.166	ko:K02427	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ
HKD2_k127_5331816_15	1123267.JONN01000001_gene1710	6.279e-163	519.0	COG0248@1|root,COG0248@2|Bacteria,1MV35@1224|Proteobacteria,2TT2C@28211|Alphaproteobacteria,2K1HK@204457|Sphingomonadales	204457|Sphingomonadales	FP	exopolyphosphatase	-	-	3.6.1.11,3.6.1.40	ko:K01524	ko00230,map00230	-	R03409	RC00002	ko00000,ko00001,ko01000	-	-	-	Ppx-GppA
HKD2_k127_5331816_69	1144310.PMI07_001442	1.103e-07	57.0	COG2801@1|root,COG2801@2|Bacteria,1N207@1224|Proteobacteria,2UEQQ@28211|Alphaproteobacteria,4BC7V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Function proposed based on presence of conserved amino acid motif, structural feature or limited homology	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_28,HTH_32,rve,rve_3
HKD2_k127_5331816_7	1090319.KE386571_gene1011	2.88e-230	722.0	COG0554@1|root,COG0554@2|Bacteria,1MUP7@1224|Proteobacteria,2TRD7@28211|Alphaproteobacteria,2K01R@204457|Sphingomonadales	204457|Sphingomonadales	C	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate	glpK	GO:0003674,GO:0003824,GO:0004370,GO:0005975,GO:0006066,GO:0006071,GO:0006793,GO:0006796,GO:0008150,GO:0008152,GO:0009987,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016773,GO:0019400,GO:0019751,GO:0044237,GO:0044238,GO:0044262,GO:0044281,GO:0071704,GO:1901615	2.7.1.30	ko:K00864	ko00561,ko01100,ko03320,ko04626,map00561,map01100,map03320,map04626	-	R00847	RC00002,RC00017	ko00000,ko00001,ko01000,ko04147	-	-	-	FGGY_C,FGGY_N
HKD2_k127_5331816_13	317655.Sala_0753	3.867e-178	571.0	COG3507@1|root,COG3507@2|Bacteria,1R5F2@1224|Proteobacteria	1224|Proteobacteria	G	Belongs to the glycosyl hydrolase 43 family	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_43
HKD2_k127_5331816_65	1121930.AQXG01000017_gene3165	8.347e-14	80.0	2FECF@1|root,346C7@2|Bacteria,4P54D@976|Bacteroidetes	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_31	450851.PHZ_c3271	1.405e-108	362.0	COG0625@1|root,COG0625@2|Bacteria,1NUET@1224|Proteobacteria,2TRGC@28211|Alphaproteobacteria,2KJCX@204458|Caulobacterales	204458|Caulobacterales	O	Glutathione S-transferase, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	GST_C_2,GST_N_3
HKD2_k127_5331816_54	1123267.JONN01000001_gene1712	6.908e-61	217.0	COG0784@1|root,COG0784@2|Bacteria,1Q8CG@1224|Proteobacteria,2VEIV@28211|Alphaproteobacteria,2K7Z1@204457|Sphingomonadales	204457|Sphingomonadales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_5331816_58	1123267.JONN01000001_gene1713	7.058e-44	170.0	COG3773@1|root,COG3773@2|Bacteria,1RDSV@1224|Proteobacteria,2U8XY@28211|Alphaproteobacteria,2K4PG@204457|Sphingomonadales	2|Bacteria	M	COG3773 Cell wall hydrolyses involved in spore germination	cwlJ	-	3.5.1.28	ko:K01449	-	-	R04112	RC00064,RC00141	ko00000,ko01000	-	-	-	Hydrolase_2
HKD2_k127_5331816_55	1030157.AFMP01000019_gene660	4.632e-54	193.0	COG2947@1|root,COG2947@2|Bacteria,1RHRU@1224|Proteobacteria,2U71N@28211|Alphaproteobacteria,2K5EU@204457|Sphingomonadales	204457|Sphingomonadales	S	EVE domain	-	-	-	-	-	-	-	-	-	-	-	-	EVE
HKD2_k127_5331816_66	1073999.BN137_3390	4.182e-13	77.0	2C67P@1|root,32ZG4@2|Bacteria,1NAHR@1224|Proteobacteria,1SFUH@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF3828)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3828
HKD2_k127_5331816_4	627192.SLG_33740	1.887e-309	957.0	COG1217@1|root,COG1217@2|Bacteria,1MV5Q@1224|Proteobacteria,2TR63@28211|Alphaproteobacteria,2K169@204457|Sphingomonadales	204457|Sphingomonadales	T	GTP-binding protein TypA	typA	-	-	ko:K06207	-	-	-	-	ko00000	-	-	-	EFG_C,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_5331816_64	1123267.JONN01000001_gene1715	3.606e-20	92.0	COG3668@1|root,32ZH9@2|Bacteria,1N7YH@1224|Proteobacteria,2UC0X@28211|Alphaproteobacteria,2K645@204457|Sphingomonadales	204457|Sphingomonadales	S	Plasmid stabilization	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5331816_70	1450694.BTS2_2398	5.984e-06	53.0	COG1846@1|root,COG1846@2|Bacteria,1V9RE@1239|Firmicutes,4HJ9C@91061|Bacilli,1ZR4W@1386|Bacillus	91061|Bacilli	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_5331816_25	1123267.JONN01000001_gene1716	2.864e-133	436.0	COG0477@1|root,COG2814@2|Bacteria,1NGB4@1224|Proteobacteria,2TWAK@28211|Alphaproteobacteria,2K8XV@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major Facilitator Superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_5331816_47	1449049.JONW01000005_gene1637	4.013e-69	240.0	COG1309@1|root,COG1309@2|Bacteria,1MVQV@1224|Proteobacteria,2TRPA@28211|Alphaproteobacteria,2KH4Q@204458|Caulobacterales	204458|Caulobacterales	K	Bacterial regulatory proteins, tetR family	-	-	-	-	-	-	-	-	-	-	-	-	TetR_C_11,TetR_N
HKD2_k127_5331816_29	629773.AORY01000004_gene90	1.253e-112	381.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria,2K0XN@204457|Sphingomonadales	204457|Sphingomonadales	MU	COG1538 Outer membrane protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_5331816_49	450851.PHZ_c0717	1.482e-66	239.0	COG0845@1|root,COG0845@2|Bacteria,1R3U4@1224|Proteobacteria,2TW9A@28211|Alphaproteobacteria,2KJVA@204458|Caulobacterales	204458|Caulobacterales	M	HlyD family secretion protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD2_k127_5331816_23	69395.JQLZ01000004_gene782	1.382e-135	446.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TR2P@28211|Alphaproteobacteria,2KFF0@204458|Caulobacterales	204458|Caulobacterales	V	ABC transporter	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5331816_18	69395.JQLZ01000004_gene783	1.167e-149	481.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2KFZ9@204458|Caulobacterales	204458|Caulobacterales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_5361652_0	1144305.PMI02_04990	8.776e-186	585.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD2_k127_5361652_1	1144305.PMI02_03141	1.042e-37	149.0	2DSP1@1|root,33GVU@2|Bacteria	2|Bacteria	S	Protein of unknown function (DUF2975)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2975
HKD2_k127_5402028_10	1411123.JQNH01000001_gene2851	4.171e-27	114.0	COG0640@1|root,COG0640@2|Bacteria,1N72Q@1224|Proteobacteria,2UFSY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	nolR	GO:0001067,GO:0003674,GO:0003676,GO:0003677,GO:0003700,GO:0005488,GO:0006355,GO:0008150,GO:0009889,GO:0010468,GO:0010556,GO:0019219,GO:0019222,GO:0031323,GO:0031326,GO:0044212,GO:0050789,GO:0050794,GO:0051171,GO:0051252,GO:0060255,GO:0065007,GO:0080090,GO:0097159,GO:0140110,GO:1901363,GO:1903506,GO:2000112,GO:2001141	-	ko:K22042	-	-	-	-	ko00000,ko03000	-	-	-	HTH_5
HKD2_k127_5402028_1	1007104.SUS17_2850	4.15e-146	469.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2K06J@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_5402028_9	158500.BV97_03113	3.655e-37	146.0	COG2391@1|root,COG2391@2|Bacteria,1MZ3A@1224|Proteobacteria,2UCDT@28211|Alphaproteobacteria,2K5A8@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulphur transport	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	Sulf_transp
HKD2_k127_5402028_8	391600.ABRU01000025_gene1176	3.579e-42	166.0	COG2391@1|root,COG2391@2|Bacteria,1MZC0@1224|Proteobacteria,2U99K@28211|Alphaproteobacteria,2KH5S@204458|Caulobacterales	204458|Caulobacterales	S	transporter component	-	-	-	ko:K07112	-	-	-	-	ko00000	-	-	-	-
HKD2_k127_5402028_11	648757.Rvan_1100	1.021e-26	122.0	COG3453@1|root,COG3453@2|Bacteria,1N9AF@1224|Proteobacteria,2UD2M@28211|Alphaproteobacteria,3N713@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	Putative phosphatase (DUF442)	-	-	1.8.5.4	ko:K17218	ko00920,map00920	-	R10152	RC03155	ko00000,ko00001,ko01000	-	-	-	DUF442
HKD2_k127_5402028_3	633149.Bresu_0727	1.781e-103	346.0	COG0730@1|root,COG0730@2|Bacteria,1MVBS@1224|Proteobacteria,2TQW0@28211|Alphaproteobacteria,2KGJH@204458|Caulobacterales	204458|Caulobacterales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_5402028_7	290397.Adeh_1021	1.652e-52	200.0	COG3239@1|root,COG3239@2|Bacteria,1PP7Y@1224|Proteobacteria,43525@68525|delta/epsilon subdivisions,2X94I@28221|Deltaproteobacteria,2Z1VN@29|Myxococcales	28221|Deltaproteobacteria	I	fatty acid desaturase	-	-	1.14.19.3	ko:K00508	ko00591,ko01100,map00591,map01100	-	R07063	RC00917	ko00000,ko00001,ko01000,ko01004	-	-	-	FA_desaturase
HKD2_k127_5402028_13	555793.WSK_2728	3.777e-11	68.0	29Z78@1|root,30M59@2|Bacteria,1P997@1224|Proteobacteria,2UY8U@28211|Alphaproteobacteria,2K89E@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5402028_14	629773.AORY01000021_gene2364	0.0008175	45.0	2AMG1@1|root,31CBI@2|Bacteria,1Q8CS@1224|Proteobacteria,2VEJ9@28211|Alphaproteobacteria,2K7ZT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5402028_12	1007104.SUS17_3013	6.131e-25	107.0	COG1278@1|root,COG1278@2|Bacteria,1N6Q5@1224|Proteobacteria,2UF6W@28211|Alphaproteobacteria,2K5Z5@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold-shock protein	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_5402028_5	883126.HMPREF9710_04532	3.413e-77	271.0	COG4188@1|root,COG4188@2|Bacteria,1MW2N@1224|Proteobacteria,2WAS9@28216|Betaproteobacteria,477BH@75682|Oxalobacteraceae	28216|Betaproteobacteria	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5402028_4	1510531.JQJJ01000016_gene3212	1.666e-101	347.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,2TT7N@28211|Alphaproteobacteria,3JQZB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EGP	Major Facilitator Superfamily	yebQ	GO:0003674,GO:0005215,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0008150,GO:0016020,GO:0016021,GO:0022857,GO:0031224,GO:0031226,GO:0044425,GO:0044459,GO:0044464,GO:0051179,GO:0051234,GO:0055085,GO:0071944	-	ko:K08169	-	-	-	-	ko00000,ko02000	2.A.1.3.17	-	-	MFS_1
HKD2_k127_5402028_6	448385.sce1118	2.304e-62	219.0	2C02K@1|root,32R69@2|Bacteria,1RK2Q@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5402028_2	395492.Rleg2_1811	4.593e-116	380.0	COG0583@1|root,COG0583@2|Bacteria,1N663@1224|Proteobacteria,2TU9J@28211|Alphaproteobacteria,4B9F0@82115|Rhizobiaceae	28211|Alphaproteobacteria	K	transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_5402028_0	1123267.JONN01000001_gene1971	6.102e-164	529.0	COG1231@1|root,COG1231@2|Bacteria,1MWPH@1224|Proteobacteria,2U05G@28211|Alphaproteobacteria,2K26X@204457|Sphingomonadales	204457|Sphingomonadales	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_5475965_27	935548.KI912159_gene866	9.729e-124	406.0	COG1226@1|root,COG1226@2|Bacteria,1MV0T@1224|Proteobacteria,2UB9U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	Castor and Pollux, part of voltage-gated ion channel	dMI1	-	-	-	-	-	-	-	-	-	-	-	Castor_Poll_mid
HKD2_k127_5475965_30	1185876.BN8_04092	5.761e-115	404.0	COG0823@1|root,COG1506@1|root,COG0823@2|Bacteria,COG1506@2|Bacteria,4NFTM@976|Bacteroidetes,47NS1@768503|Cytophagia	976|Bacteroidetes	EU	Dienelactone hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	DPPIV_N,PD40,Peptidase_S9
HKD2_k127_5475965_63	1449049.JONW01000006_gene2978	2.718e-49	186.0	COG2203@1|root,COG2203@2|Bacteria,1RGKE@1224|Proteobacteria	1224|Proteobacteria	T	GAF domain	-	-	-	-	-	-	-	-	-	-	-	-	GAF,GAF_2,HATPase_c,HisKA,PAS,PAS_3,PAS_4
HKD2_k127_5475965_45	555793.WSK_1698	4.746e-87	296.0	COG1462@1|root,COG1462@2|Bacteria,1QURH@1224|Proteobacteria,2U2ZX@28211|Alphaproteobacteria,2K2HF@204457|Sphingomonadales	204457|Sphingomonadales	M	protein involved in formation of curli polymers	-	-	-	-	-	-	-	-	-	-	-	-	CsgG,SH3_3
HKD2_k127_5475965_3	745310.G432_09235	0.0	1051.0	COG0481@1|root,COG0481@2|Bacteria,1MVZA@1224|Proteobacteria,2TR3H@28211|Alphaproteobacteria,2K17X@204457|Sphingomonadales	204457|Sphingomonadales	M	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner	lepA	-	-	ko:K03596	ko05134,map05134	-	-	-	ko00000,ko00001	-	-	-	EFG_C,EFG_II,GTP_EFTU,GTP_EFTU_D2,LepA_C
HKD2_k127_5475965_74	43989.cce_1250	0.0006157	48.0	2EB3I@1|root,33549@2|Bacteria,1GE1I@1117|Cyanobacteria	1117|Cyanobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5475965_59	1449049.JONW01000013_gene4716	2.077e-63	227.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,2VEWI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD2_k127_5475965_72	1144305.PMI02_03109	9.146e-13	78.0	2E8Y7@1|root,3337X@2|Bacteria,1NBJG@1224|Proteobacteria,2UW7G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5475965_5	1123267.JONN01000001_gene2357	3.005e-268	850.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K01C@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,PAS_4,Response_reg
HKD2_k127_5475965_9	1040989.AWZU01000005_gene368	8.575e-205	649.0	COG0467@1|root,COG0467@2|Bacteria,1NEWW@1224|Proteobacteria,2TRTV@28211|Alphaproteobacteria,3JV7U@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	GvpD gas vesicle protein	-	-	-	ko:K08482	-	-	-	-	ko00000	-	-	-	ATPase
HKD2_k127_5475965_22	69395.JQLZ01000003_gene314	6.574e-138	458.0	COG4191@1|root,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_3,Response_reg
HKD2_k127_5475965_71	1132836.RCCGE510_09985	3.759e-14	74.0	COG0596@1|root,COG0596@2|Bacteria,1MWT6@1224|Proteobacteria,2TSCE@28211|Alphaproteobacteria,4B88J@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_5475965_13	990285.RGCCGE502_16080	2.019e-192	617.0	COG0596@1|root,COG0596@2|Bacteria,1MWVN@1224|Proteobacteria,2TQVB@28211|Alphaproteobacteria,4B7GV@82115|Rhizobiaceae	28211|Alphaproteobacteria	Q	epoxide hydrolase	-	-	3.3.2.9	ko:K01253,ko:K21159	ko00980,ko01059,ko04976,ko05204,map00980,map01059,map04976,map05204	-	R07013,R07014,R07027,R07071,R07072,R07082,R09410,R09417,R09443	RC01447,RC01728,RC01764,RC02528	ko00000,ko00001,ko01000,ko01002	-	-	-	EHN
HKD2_k127_5475965_21	1123267.JONN01000001_gene1786	9.584e-139	456.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,2K2BZ@204457|Sphingomonadales	204457|Sphingomonadales	KT	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,Trans_reg_C
HKD2_k127_5475965_4	1219045.BV98_002582	8.385e-303	939.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	-	-	-	-	-	-	-	-	-	-	-	-	K_trans
HKD2_k127_5475965_64	702113.PP1Y_AT11879	2.823e-45	172.0	COG2197@1|root,COG2197@2|Bacteria,1NQH7@1224|Proteobacteria,2VEVJ@28211|Alphaproteobacteria,2K6C9@204457|Sphingomonadales	204457|Sphingomonadales	KT	helix_turn_helix, Lux Regulon	-	-	-	ko:K07685	ko02020,map02020	M00472	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	GerE,Response_reg
HKD2_k127_5475965_58	279238.Saro_1237	4.334e-64	240.0	COG4585@1|root,COG4585@2|Bacteria,1RKV1@1224|Proteobacteria,2U32D@28211|Alphaproteobacteria,2KDGC@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_5475965_1	1123267.JONN01000001_gene2358	0.0	1207.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K07A@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS
HKD2_k127_5475965_15	1123267.JONN01000001_gene2355	6.008e-171	544.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U16F@28211|Alphaproteobacteria,2JZWJ@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,His_kinase
HKD2_k127_5475965_20	1123267.JONN01000001_gene2356	5.039e-143	457.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2TSPC@28211|Alphaproteobacteria,2K1DU@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator of the LytR AlgR family	-	-	-	ko:K02477	-	-	-	-	ko00000,ko02022	-	-	-	LytTR,Response_reg
HKD2_k127_5475965_68	1121124.JNIX01000015_gene2037	2.566e-24	107.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria,2KH28@204458|Caulobacterales	204458|Caulobacterales	T	Response regulator receiver	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_5475965_40	1090318.ATTI01000001_gene2079	7.725e-97	329.0	COG5002@1|root,COG5002@2|Bacteria,1MWF3@1224|Proteobacteria,2TR46@28211|Alphaproteobacteria,2K1ZG@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	phoR	-	2.7.13.3	ko:K07636	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_8
HKD2_k127_5475965_26	1030157.AFMP01000031_gene2910	6.429e-126	422.0	COG3746@1|root,COG3746@2|Bacteria,1RA39@1224|Proteobacteria,2U0ZX@28211|Alphaproteobacteria,2K1KI@204457|Sphingomonadales	204457|Sphingomonadales	P	phosphate-selective porin	-	-	-	ko:K07221	-	-	-	-	ko00000,ko02000	1.B.5.1	-	-	Porin_O_P
HKD2_k127_5475965_24	1458357.BG58_13995	6.746e-130	424.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,1K0BS@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_5475965_14	1081640.AGFU01000051_gene867	5.279e-174	550.0	COG0306@1|root,COG0306@2|Bacteria,1MVXK@1224|Proteobacteria,2TSYI@28211|Alphaproteobacteria,2JZVM@204457|Sphingomonadales	204457|Sphingomonadales	P	phosphate transporter	-	-	-	ko:K03306	-	-	-	-	ko00000	2.A.20	-	-	PHO4
HKD2_k127_5475965_50	1449076.JOOE01000001_gene2261	3.867e-77	264.0	COG1392@1|root,COG1392@2|Bacteria,1QV5N@1224|Proteobacteria,2TWA9@28211|Alphaproteobacteria,2K1CT@204457|Sphingomonadales	204457|Sphingomonadales	P	Phosphate transport regulator	-	-	-	ko:K07220	-	-	-	-	ko00000	-	-	-	NUDIX,PhoU_div
HKD2_k127_5475965_37	392499.Swit_3577	1.073e-105	348.0	COG0745@1|root,COG0745@2|Bacteria,1MY2Z@1224|Proteobacteria,2TRFZ@28211|Alphaproteobacteria,2K0QB@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	phoB	-	-	ko:K07657	ko02020,map02020	M00434	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5475965_31	1123267.JONN01000001_gene1843	2.963e-114	376.0	COG0704@1|root,COG0704@2|Bacteria,1MUMI@1224|Proteobacteria,2TQMN@28211|Alphaproteobacteria,2K0AA@204457|Sphingomonadales	204457|Sphingomonadales	P	Plays a role in the regulation of phosphate uptake	phoU	GO:0003674,GO:0005488,GO:0005515,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0008150,GO:0009892,GO:0010563,GO:0010966,GO:0019220,GO:0019222,GO:0031323,GO:0031324,GO:0032879,GO:0034762,GO:0034763,GO:0034765,GO:0034766,GO:0042802,GO:0042803,GO:0043269,GO:0043271,GO:0044070,GO:0044424,GO:0044464,GO:0045936,GO:0046983,GO:0048519,GO:0048523,GO:0050789,GO:0050794,GO:0051049,GO:0051051,GO:0051174,GO:0065007,GO:1903792,GO:1903795,GO:1903796,GO:1903959,GO:1903960,GO:2000185,GO:2000186	-	ko:K02039	-	-	-	-	ko00000	-	-	-	PhoU
HKD2_k127_5475965_33	316057.RPD_0891	3.467e-112	368.0	COG1117@1|root,COG1117@2|Bacteria,1MU16@1224|Proteobacteria,2TQX9@28211|Alphaproteobacteria,3JTBM@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system	pstB	-	3.6.3.27	ko:K02036	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.7	-	-	ABC_tran
HKD2_k127_5475965_34	1246459.KB898357_gene1484	6.645e-110	365.0	COG0581@1|root,COG0581@2|Bacteria,1MUWB@1224|Proteobacteria,2TQYQ@28211|Alphaproteobacteria,4BCJY@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Binding-protein-dependent transport system inner membrane component	pstA	GO:0003674,GO:0005215,GO:0005315,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006810,GO:0006811,GO:0006817,GO:0006820,GO:0006950,GO:0006974,GO:0008150,GO:0009987,GO:0010921,GO:0015291,GO:0015318,GO:0015698,GO:0016020,GO:0016021,GO:0019220,GO:0019222,GO:0022804,GO:0022857,GO:0031224,GO:0031226,GO:0031323,GO:0033554,GO:0034220,GO:0035303,GO:0035435,GO:0044425,GO:0044459,GO:0044464,GO:0050789,GO:0050790,GO:0050794,GO:0050896,GO:0051174,GO:0051179,GO:0051234,GO:0051336,GO:0051716,GO:0055085,GO:0065007,GO:0065009,GO:0071944,GO:0098656,GO:0098660,GO:0098661	-	ko:K02038	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_5475965_25	1156919.QWC_00080	3.641e-129	420.0	COG0573@1|root,COG0573@2|Bacteria,1MVKP@1224|Proteobacteria,2VH4G@28216|Betaproteobacteria,3T2SF@506|Alcaligenaceae	28216|Betaproteobacteria	P	probably responsible for the translocation of the substrate across the membrane	pstC	-	-	ko:K02037	ko02010,map02010	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	BPD_transp_1
HKD2_k127_5475965_23	1458357.BG58_13995	1.859e-136	442.0	COG0226@1|root,COG0226@2|Bacteria,1MUAZ@1224|Proteobacteria,2VIJV@28216|Betaproteobacteria,1K0BS@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Part of the ABC transporter complex PstSACB involved in phosphate import	-	-	-	ko:K02040	ko02010,ko02020,ko05152,map02010,map02020,map05152	M00222	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.7	-	-	PBP_like_2
HKD2_k127_5475965_46	1449076.JOOE01000004_gene493	4.47e-82	279.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2U3CR@28211|Alphaproteobacteria,2K4EU@204457|Sphingomonadales	204457|Sphingomonadales	G	COG2513 PEP phosphonomutase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HKD2_k127_5475965_47	1449076.JOOE01000004_gene493	1.114e-80	276.0	COG2513@1|root,COG2513@2|Bacteria,1R3SD@1224|Proteobacteria,2U3CR@28211|Alphaproteobacteria,2K4EU@204457|Sphingomonadales	204457|Sphingomonadales	G	COG2513 PEP phosphonomutase and related enzymes	-	-	-	-	-	-	-	-	-	-	-	-	PEP_mutase
HKD2_k127_5475965_38	1123267.JONN01000001_gene2302	2.359e-102	347.0	COG1668@1|root,COG1668@2|Bacteria,1MWAS@1224|Proteobacteria,2TU2K@28211|Alphaproteobacteria,2K1E9@204457|Sphingomonadales	204457|Sphingomonadales	CP	ABC-type Na efflux pump, permease component	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_5475965_19	1123267.JONN01000001_gene2303	4.922e-145	468.0	COG4152@1|root,COG4152@2|Bacteria,1QUPV@1224|Proteobacteria,2TW40@28211|Alphaproteobacteria,2JZWA@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC transporter, ATP-binding protein	-	-	-	ko:K01990	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5475965_18	13690.CP98_04391	2.254e-150	482.0	COG1600@1|root,COG1600@2|Bacteria,1MV1H@1224|Proteobacteria,2TR5E@28211|Alphaproteobacteria,2K0HW@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)	queG	-	1.17.99.6	ko:K18979	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DUF1730,Fer4_16
HKD2_k127_5475965_70	1081640.AGFU01000026_gene2641	5.438e-19	91.0	2EHHR@1|root,33B9P@2|Bacteria,1NGHW@1224|Proteobacteria,2UJVS@28211|Alphaproteobacteria,2K6SJ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5475965_29	627192.SLG_38710	2.311e-119	391.0	COG0524@1|root,COG0524@2|Bacteria,1MUUC@1224|Proteobacteria,2TS9D@28211|Alphaproteobacteria,2K0DX@204457|Sphingomonadales	204457|Sphingomonadales	G	Carbohydrate kinase	-	-	-	-	-	-	-	-	-	-	-	-	PfkB
HKD2_k127_5475965_6	1292034.OR37_02259	5.491e-262	816.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,2KEXX@204458|Caulobacterales	204458|Caulobacterales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_5475965_55	1120705.FG95_00068	6.986e-65	223.0	COG0537@1|root,COG0537@2|Bacteria,1RDCJ@1224|Proteobacteria,2U956@28211|Alphaproteobacteria,2K4G2@204457|Sphingomonadales	204457|Sphingomonadales	FG	COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HKD2_k127_5475965_41	204669.Acid345_3933	1.156e-92	312.0	COG0823@1|root,COG0823@2|Bacteria,3Y95P@57723|Acidobacteria	57723|Acidobacteria	U	WD40-like Beta Propeller Repeat	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_5475965_52	1123267.JONN01000001_gene2309	3.278e-67	232.0	COG3814@1|root,COG3814@2|Bacteria,1N1FE@1224|Proteobacteria,2U7H9@28211|Alphaproteobacteria,2K35H@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09985	-	-	-	-	ko00000	-	-	-	SspB
HKD2_k127_5475965_10	1112214.AHIS01000009_gene153	1.012e-201	638.0	COG0114@1|root,COG0114@2|Bacteria,1MUQI@1224|Proteobacteria,2TQM7@28211|Alphaproteobacteria,2K0K7@204457|Sphingomonadales	204457|Sphingomonadales	C	Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate	fumC	-	4.2.1.2	ko:K01679	ko00020,ko00620,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko04934,ko05200,ko05211,map00020,map00620,map00720,map01100,map01110,map01120,map01130,map01200,map04934,map05200,map05211	M00009,M00011,M00173,M00376	R01082	RC00443	ko00000,ko00001,ko00002,ko01000	-	-	-	FumaraseC_C,Lyase_1
HKD2_k127_5475965_54	1114970.PSF113_2230	5.574e-65	226.0	COG3791@1|root,COG3791@2|Bacteria,1RH2A@1224|Proteobacteria,1S4BR@1236|Gammaproteobacteria,1YUSM@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_5475965_61	1123267.JONN01000001_gene2379	4.3e-58	206.0	2BYSU@1|root,32R3U@2|Bacteria,1MZ0R@1224|Proteobacteria,2U9AE@28211|Alphaproteobacteria,2K44Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Lipid A 3-O-deacylase (PagL)	-	-	-	-	-	-	-	-	-	-	-	-	PagL
HKD2_k127_5475965_62	1449065.JMLL01000010_gene555	4.009e-56	204.0	29CWT@1|root,2ZZUX@2|Bacteria,1REF2@1224|Proteobacteria,2U7K7@28211|Alphaproteobacteria,43J2Y@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	S	UPF0314 protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2585
HKD2_k127_5475965_35	1123267.JONN01000001_gene2382	5.725e-108	360.0	COG0598@1|root,COG0598@2|Bacteria,1MWMP@1224|Proteobacteria,2TQQD@28211|Alphaproteobacteria,2K4ZK@204457|Sphingomonadales	204457|Sphingomonadales	P	CorA-like Mg2+ transporter protein	-	-	-	ko:K03284	-	-	-	-	ko00000,ko02000	1.A.35.1,1.A.35.3	-	-	CorA
HKD2_k127_5475965_66	1131814.JAFO01000001_gene2137	2.322e-43	170.0	COG2819@1|root,COG2819@2|Bacteria,1RB1X@1224|Proteobacteria,2TUQ2@28211|Alphaproteobacteria,3EZ3W@335928|Xanthobacteraceae	28211|Alphaproteobacteria	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
HKD2_k127_5475965_0	1123267.JONN01000001_gene2385	0.0	1516.0	COG1048@1|root,COG1048@2|Bacteria,1MU9T@1224|Proteobacteria,2TT3T@28211|Alphaproteobacteria,2K0CP@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate	acnA	-	4.2.1.3	ko:K01681	ko00020,ko00630,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00173,M00740	R01324,R01325,R01900	RC00497,RC00498,RC00618	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Aconitase,Aconitase_C
HKD2_k127_5475965_69	1280949.HAD_01410	1.319e-21	98.0	2EFVT@1|root,339N0@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Imp-YgjV
HKD2_k127_5475965_43	1144307.PMI04_02379	3.889e-88	301.0	COG1878@1|root,COG1878@2|Bacteria,1R8IH@1224|Proteobacteria,2U9RH@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Cyclase
HKD2_k127_5475965_51	1123267.JONN01000001_gene1705	1.699e-71	269.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1NCCW@1224|Proteobacteria,2UGC8@28211|Alphaproteobacteria,2K3I7@204457|Sphingomonadales	204457|Sphingomonadales	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HKD2_k127_5475965_32	1123267.JONN01000001_gene2387	2.126e-113	369.0	COG0354@1|root,COG0354@2|Bacteria,1N852@1224|Proteobacteria,2TR8J@28211|Alphaproteobacteria,2K18B@204457|Sphingomonadales	204457|Sphingomonadales	S	Aminomethyltransferase	-	-	-	ko:K06980	-	-	-	-	ko00000,ko03016	-	-	-	GCV_T
HKD2_k127_5475965_17	1123267.JONN01000001_gene2388	1.511e-154	494.0	COG0418@1|root,COG0418@2|Bacteria,1MUYP@1224|Proteobacteria,2TT2U@28211|Alphaproteobacteria,2K057@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate	pyrC	-	3.5.2.3	ko:K01465	ko00240,ko01100,map00240,map01100	M00051	R01993	RC00632	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1
HKD2_k127_5475965_44	1123267.JONN01000001_gene2389	2.348e-87	295.0	COG0664@1|root,COG0664@2|Bacteria,1NEQM@1224|Proteobacteria,2TQXG@28211|Alphaproteobacteria,2K1GD@204457|Sphingomonadales	204457|Sphingomonadales	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2
HKD2_k127_5475965_28	1123267.JONN01000001_gene512	4.729e-121	402.0	COG0673@1|root,COG0673@2|Bacteria,1MW0Q@1224|Proteobacteria,2TQR0@28211|Alphaproteobacteria,2K0NU@204457|Sphingomonadales	204457|Sphingomonadales	S	Galactose 1-dehydrogenase	-	-	1.1.1.48	ko:K00035	ko00052,ko01100,map00052,map01100	-	R01094,R01097	RC00161	ko00000,ko00001,ko01000	-	-	-	GFO_IDH_MocA
HKD2_k127_5475965_48	1123267.JONN01000001_gene513	3.305e-78	266.0	COG0800@1|root,COG0800@2|Bacteria,1RD0T@1224|Proteobacteria,2U7AQ@28211|Alphaproteobacteria,2K1WJ@204457|Sphingomonadales	204457|Sphingomonadales	G	Aldolase	-	-	4.1.2.21	ko:K01631	ko00052,ko01100,map00052,map01100	M00552	R01064	RC00307,RC00435	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldolase
HKD2_k127_5475965_42	1123267.JONN01000001_gene514	6.279e-89	302.0	COG3734@1|root,COG3734@2|Bacteria,1MWGX@1224|Proteobacteria,2TTG8@28211|Alphaproteobacteria,2K1K8@204457|Sphingomonadales	204457|Sphingomonadales	G	2-keto-3-deoxy-galactonokinase	dgoK	-	2.7.1.58	ko:K00883	ko00052,ko01100,map00052,map01100	M00552	R03387	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	DGOK
HKD2_k127_5475965_36	1123267.JONN01000001_gene515	7.666e-108	356.0	COG3386@1|root,COG3386@2|Bacteria,1MWTR@1224|Proteobacteria,2TV5X@28211|Alphaproteobacteria,2K16R@204457|Sphingomonadales	204457|Sphingomonadales	G	Gluconolactonase	-	-	-	ko:K14274	ko00040,map00040	-	R02427	RC00713	ko00000,ko00001,ko01000	-	-	-	SGL
HKD2_k127_5475965_7	1123267.JONN01000001_gene516	6.547e-232	724.0	COG2723@1|root,COG2723@2|Bacteria,1MWU7@1224|Proteobacteria,2TT4I@28211|Alphaproteobacteria,2K354@204457|Sphingomonadales	204457|Sphingomonadales	G	Glycosyl hydrolase family 1	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_hydro_1
HKD2_k127_5475965_12	1123267.JONN01000001_gene517	2.127e-198	623.0	COG4948@1|root,COG4948@2|Bacteria,1MURK@1224|Proteobacteria,2TRS9@28211|Alphaproteobacteria,2KCTY@204457|Sphingomonadales	204457|Sphingomonadales	M	mandelate racemase muconate lactonizing	-	-	4.2.1.6,4.2.1.8,5.1.2.2	ko:K01684,ko:K01781,ko:K08323	ko00040,ko00052,ko00627,ko01100,ko01120,map00040,map00052,map00627,map01100,map01120	M00061,M00552	R03033,R03791,R04161,R05606	RC00543,RC00998	ko00000,ko00001,ko00002,ko01000	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_5475965_65	1048339.KB913029_gene879	6.194e-44	161.0	COG3813@1|root,COG3813@2|Bacteria,2I06T@201174|Actinobacteria,4ESZX@85013|Frankiales	201174|Actinobacteria	S	Protein of unknown function (DUF1272)	-	-	-	ko:K09984	-	-	-	-	ko00000	-	-	-	DUF1272
HKD2_k127_5475965_60	1090320.KB900605_gene3037	4.242e-59	210.0	COG2151@1|root,COG2151@2|Bacteria,1RF3S@1224|Proteobacteria,2TRQW@28211|Alphaproteobacteria,2K4PD@204457|Sphingomonadales	204457|Sphingomonadales	L	Iron-sulfur cluster assembly protein	-	-	-	ko:K02612	ko00360,ko01120,map00360,map01120	-	R09838	RC02690	ko00000,ko00001	-	-	-	FeS_assembly_P
HKD2_k127_5475965_11	1123267.JONN01000001_gene2369	1.775e-198	628.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K04I@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the thiolase family	-	-	-	-	-	-	-	-	-	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_5475965_16	1380394.JADL01000012_gene1023	4.146e-155	497.0	COG3185@1|root,COG3185@2|Bacteria,1MUVZ@1224|Proteobacteria,2TRCC@28211|Alphaproteobacteria,2JQJ4@204441|Rhodospirillales	204441|Rhodospirillales	E	Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal	-	-	1.13.11.27	ko:K00457	ko00130,ko00350,ko00360,ko01100,map00130,map00350,map00360,map01100	M00044	R01372,R02521	RC00505,RC00738	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase,Glyoxalase_5
HKD2_k127_5475965_67	1123267.JONN01000001_gene2371	1.002e-27	115.0	COG2154@1|root,COG2154@2|Bacteria,1MZ5Q@1224|Proteobacteria,2UBWN@28211|Alphaproteobacteria,2K5VW@204457|Sphingomonadales	204457|Sphingomonadales	H	pterin-4-alpha-carbinolamine dehydratase	phhB	-	4.2.1.96	ko:K01724	ko00790,map00790	-	R04734	RC01208	ko00000,ko00001,ko01000,ko04147	-	-	-	Pterin_4a
HKD2_k127_5475965_53	1219035.NT2_07_00590	7.071e-66	234.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_5475965_49	1123267.JONN01000001_gene2373	2.701e-77	267.0	COG3186@1|root,COG3186@2|Bacteria,1MU29@1224|Proteobacteria,2TU1E@28211|Alphaproteobacteria,2K01F@204457|Sphingomonadales	204457|Sphingomonadales	E	Phenylalanine-4-hydroxylase	phhA	-	1.14.16.1	ko:K00500	ko00360,ko00400,ko00790,ko01100,ko01230,map00360,map00400,map00790,map01100,map01230	-	R01795,R07211	RC00490	ko00000,ko00001,ko01000	-	-	-	Biopterin_H
HKD2_k127_5475965_2	685778.AORL01000021_gene958	0.0	1058.0	COG1505@1|root,COG1505@2|Bacteria,1NZ7N@1224|Proteobacteria,2TTAX@28211|Alphaproteobacteria,2KDD3@204457|Sphingomonadales	204457|Sphingomonadales	E	COG1505 Serine proteases of the peptidase family S9A	-	-	3.4.21.26	ko:K01322	ko04614,map04614	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD2_k127_5475965_57	228405.HNE_1809	1.336e-64	228.0	COG1853@1|root,COG1853@2|Bacteria,1RGYM@1224|Proteobacteria,2UCHI@28211|Alphaproteobacteria,43YGP@69657|Hyphomonadaceae	28211|Alphaproteobacteria	K	COG1853 Conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Flavin_Reduct,Hydrolase_4
HKD2_k127_5475965_39	194867.ALBQ01000014_gene539	1.433e-100	336.0	COG2354@1|root,COG2354@2|Bacteria,1MVYU@1224|Proteobacteria,2TU43@28211|Alphaproteobacteria,2K0C1@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09781	-	-	-	-	ko00000	-	-	-	DUF808
HKD2_k127_5475965_8	1123267.JONN01000001_gene2376	5.305e-210	660.0	COG0172@1|root,COG0172@2|Bacteria,1MUJF@1224|Proteobacteria,2TR4T@28211|Alphaproteobacteria,2K0IX@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)	serS	-	6.1.1.11	ko:K01875	ko00970,map00970	M00359,M00360	R03662,R08218	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Seryl_tRNA_N,tRNA-synt_2b
HKD2_k127_5475965_56	1123267.JONN01000001_gene2375	8.044e-65	229.0	COG1075@1|root,COG1075@2|Bacteria,1NJNA@1224|Proteobacteria,2TSQC@28211|Alphaproteobacteria,2K4XJ@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD2_k127_5479237_2	644282.Deba_2565	1.019e-33	136.0	COG0603@1|root,COG0603@2|Bacteria,1MXFU@1224|Proteobacteria,42T68@68525|delta/epsilon subdivisions,2WS4G@28221|Deltaproteobacteria	28221|Deltaproteobacteria	F	PP-loop superfamily ATPase	-	-	-	-	-	-	-	-	-	-	-	-	QueC
HKD2_k127_5479237_3	1267005.KB911264_gene3110	5.875e-21	96.0	COG0535@1|root,COG0535@2|Bacteria,1MUQP@1224|Proteobacteria,2TTS5@28211|Alphaproteobacteria,3N63X@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	biosynthesis protein E	pqqE	-	-	ko:K06139	-	-	-	-	ko00000	-	-	-	Fer4_12,PqqD,Radical_SAM,SPASM
HKD2_k127_5479237_1	1380394.JADL01000001_gene2315	2.17e-58	212.0	COG3751@1|root,COG3751@2|Bacteria,1R4BC@1224|Proteobacteria,2U2Q5@28211|Alphaproteobacteria,2JYT8@204441|Rhodospirillales	204441|Rhodospirillales	O	2OG-Fe(II) oxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_3
HKD2_k127_5479237_0	670307.HYPDE_32348	1.793e-121	409.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,3N7R3@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	T	Diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GAF,GGDEF,PAS_3,PAS_4,PAS_9
HKD2_k127_56066_3	1123367.C666_00225	2.637e-47	171.0	COG0726@1|root,COG0726@2|Bacteria,1MWMZ@1224|Proteobacteria,2VIB9@28216|Betaproteobacteria,2KU7E@206389|Rhodocyclales	206389|Rhodocyclales	G	polysaccharide deactylase family protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF3473,Polysacc_deac_1
HKD2_k127_56066_0	497321.C664_09430	1.93e-146	477.0	COG2348@1|root,COG2348@2|Bacteria,1MXFY@1224|Proteobacteria,2VNEW@28216|Betaproteobacteria,2KVBP@206389|Rhodocyclales	206389|Rhodocyclales	V	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_6
HKD2_k127_56066_1	1288494.EBAPG3_28770	4.891e-124	416.0	COG1269@1|root,COG1269@2|Bacteria,1MXZG@1224|Proteobacteria,2VMAH@28216|Betaproteobacteria,371Y3@32003|Nitrosomonadales	28216|Betaproteobacteria	C	Protein of unknown function (DUF3485)	epsH	-	-	-	-	-	-	-	-	-	-	-	DUF3485,Exosortase_EpsH
HKD2_k127_56066_2	1304883.KI912532_gene2914	3.793e-85	290.0	COG0438@1|root,COG0438@2|Bacteria,1MU9C@1224|Proteobacteria,2VIBU@28216|Betaproteobacteria,2KUXN@206389|Rhodocyclales	206389|Rhodocyclales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_5617525_83	1123487.KB892848_gene735	1.172e-17	82.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2VI0E@28216|Betaproteobacteria,2KVNH@206389|Rhodocyclales	206389|Rhodocyclales	L	PFAM Integrase core domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
HKD2_k127_5617525_37	670307.HYPDE_26288	9.125e-117	393.0	COG0654@1|root,COG0654@2|Bacteria,1R7KI@1224|Proteobacteria,2TV6E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	CH	FAD binding domain	-	-	-	-	-	-	-	-	-	-	-	-	FAD_binding_3
HKD2_k127_5617525_45	1120705.FG95_01801	6.272e-85	289.0	COG0625@1|root,COG0625@2|Bacteria	2|Bacteria	O	glutathione transferase activity	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C_2,GST_C_5,GST_N_2,GST_N_3
HKD2_k127_5617525_69	1120705.FG95_01800	4.072e-38	146.0	COG1733@1|root,COG1733@2|Bacteria,1N0WG@1224|Proteobacteria,2U9MA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_5617525_62	419610.Mext_0751	2.421e-49	180.0	COG3837@1|root,COG3837@2|Bacteria,1PR0E@1224|Proteobacteria,2VARQ@28211|Alphaproteobacteria,1JYIE@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_64	1550073.JROH01000007_gene1877	1.805e-47	187.0	COG3175@1|root,COG3175@2|Bacteria,1RDTU@1224|Proteobacteria,2U6ZT@28211|Alphaproteobacteria,2K3WU@204457|Sphingomonadales	204457|Sphingomonadales	O	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I	ctaG	-	-	ko:K02258	ko00190,ko01100,ko04714,map00190,map01100,map04714	M00154	-	-	ko00000,ko00001,ko00002,ko03029	3.D.4.8	-	-	CtaG_Cox11
HKD2_k127_5617525_85	1316936.K678_12127	9.091e-15	84.0	COG0664@1|root,COG0664@2|Bacteria,1R5P7@1224|Proteobacteria,2TV0F@28211|Alphaproteobacteria,2JT6E@204441|Rhodospirillales	204441|Rhodospirillales	K	COG0664 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases	-	-	-	ko:K21563	-	-	-	-	ko00000,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_5617525_16	1040989.AWZU01000014_gene4513	1.237e-184	587.0	COG0038@1|root,COG0038@2|Bacteria,1MV4K@1224|Proteobacteria,2TT6V@28211|Alphaproteobacteria,3JX9K@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Voltage gated chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	Voltage_CLC
HKD2_k127_5617525_30	1030157.AFMP01000016_gene2389	2.324e-134	444.0	COG1808@1|root,COG2885@1|root,COG1808@2|Bacteria,COG2885@2|Bacteria,1NMS3@1224|Proteobacteria,2U1ZY@28211|Alphaproteobacteria,2K04U@204457|Sphingomonadales	204457|Sphingomonadales	PT	Domain of unknown function (DUF389)	-	-	-	-	-	-	-	-	-	-	-	-	DUF389
HKD2_k127_5617525_78	1449076.JOOE01000002_gene993	2.996e-22	99.0	2C12A@1|root,33B7C@2|Bacteria,1NMUW@1224|Proteobacteria,2UKV3@28211|Alphaproteobacteria,2KC7F@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_79	1449076.JOOE01000002_gene992	2.873e-20	95.0	2E40T@1|root,32YXK@2|Bacteria,1N95U@1224|Proteobacteria,2UK20@28211|Alphaproteobacteria,2KBD2@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_84	279238.Saro_3495	2.78e-15	81.0	2AEQ4@1|root,314KE@2|Bacteria,1P2CX@1224|Proteobacteria,2UUQX@28211|Alphaproteobacteria,2KBHE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_74	391600.ABRU01000021_gene865	6.562e-28	119.0	COG5573@1|root,COG5573@2|Bacteria,1RKHC@1224|Proteobacteria,2UHIW@28211|Alphaproteobacteria,2KHIE@204458|Caulobacterales	204458|Caulobacterales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5617525_86	1162668.LFE_1358	3.729e-08	57.0	COG4118@1|root,COG4118@2|Bacteria	2|Bacteria	D	positive regulation of growth	-	-	-	-	-	-	-	-	-	-	-	-	PhdYeFM_antitox
HKD2_k127_5617525_82	1110502.TMO_0670	1.04e-17	83.0	COG4374@1|root,COG4374@2|Bacteria,1N7EF@1224|Proteobacteria,2UFJV@28211|Alphaproteobacteria,2JY65@204441|Rhodospirillales	204441|Rhodospirillales	S	PIN domain	-	-	-	-	-	-	-	-	-	-	-	-	PIN
HKD2_k127_5617525_42	1449049.JONW01000010_gene3729	1.345e-99	336.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	ErfK YbiS YcfS YnhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_5617525_72	13690.CP98_00125	1.36e-29	124.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD2_k127_5617525_1	685778.AORL01000022_gene1304	0.0	1181.0	COG1185@1|root,COG1185@2|Bacteria,1MVB9@1224|Proteobacteria,2TRH3@28211|Alphaproteobacteria,2K0IJ@204457|Sphingomonadales	204457|Sphingomonadales	J	Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction	pnp	-	2.7.7.8	ko:K00962	ko00230,ko00240,ko03018,map00230,map00240,map03018	M00394	R00437,R00438,R00439,R00440	RC02795	ko00000,ko00001,ko00002,ko01000,ko03016,ko03019	-	-	-	KH_1,PNPase,RNase_PH,RNase_PH_C,S1
HKD2_k127_5617525_68	1331060.RLDS_16650	2.141e-41	153.0	COG0184@1|root,COG0184@2|Bacteria,1MZ2W@1224|Proteobacteria,2UBRZ@28211|Alphaproteobacteria,2K622@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome	rpsO	-	-	ko:K02956	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S15
HKD2_k127_5617525_40	1090319.KE386571_gene1301	4.885e-112	370.0	COG0130@1|root,COG0130@2|Bacteria,1MV0N@1224|Proteobacteria,2TSJK@28211|Alphaproteobacteria,2K00T@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs	truB	-	5.4.99.25	ko:K03177	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	TruB_C_2,TruB_N
HKD2_k127_5617525_47	1090319.KE386571_gene1300	5.247e-73	252.0	COG1994@1|root,COG1994@2|Bacteria,1NSFF@1224|Proteobacteria,2TRIF@28211|Alphaproteobacteria,2K3J2@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M50	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M50
HKD2_k127_5617525_57	1123267.JONN01000001_gene790	1.345e-59	216.0	COG1670@1|root,COG1670@2|Bacteria,1MXEE@1224|Proteobacteria,2U62V@28211|Alphaproteobacteria,2K4J7@204457|Sphingomonadales	204457|Sphingomonadales	J	Acetyltransferase (GNAT) domain	-	-	-	ko:K22479	-	-	-	-	ko00000	-	-	-	Acetyltransf_3
HKD2_k127_5617525_59	1174684.EBMC1_06940	4.14e-58	207.0	COG0858@1|root,COG0858@2|Bacteria,1MZPE@1224|Proteobacteria,2UCJF@28211|Alphaproteobacteria,2K4FV@204457|Sphingomonadales	204457|Sphingomonadales	J	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA	rbfA	-	-	ko:K02834	-	-	-	-	ko00000,ko03009	-	-	-	RBFA
HKD2_k127_5617525_0	1123267.JONN01000001_gene792	0.0	1210.0	COG0532@1|root,COG0532@2|Bacteria,1MV26@1224|Proteobacteria,2TQMY@28211|Alphaproteobacteria,2K1X7@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex	infB	-	-	ko:K02519	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	GTP_EFTU,IF-2,IF2_N,IF2_assoc
HKD2_k127_5617525_51	1112216.JH594425_gene555	6.797e-68	239.0	COG2740@1|root,COG2740@2|Bacteria,1RHPR@1224|Proteobacteria,2U9RY@28211|Alphaproteobacteria,2K2B7@204457|Sphingomonadales	204457|Sphingomonadales	K	Nucleic-acid-binding protein	-	-	-	ko:K07742	-	-	-	-	ko00000	-	-	-	DUF448
HKD2_k127_5617525_6	194867.ALBQ01000022_gene3474	4.618e-280	867.0	COG0195@1|root,COG0195@2|Bacteria,1MWT7@1224|Proteobacteria,2TRQN@28211|Alphaproteobacteria,2K1KF@204457|Sphingomonadales	204457|Sphingomonadales	K	Participates in both transcription termination and antitermination	nusA	-	-	ko:K02600	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	HHH_5,KH_5,NusA_N,S1
HKD2_k127_5617525_52	1030157.AFMP01000040_gene1494	2.738e-66	235.0	COG0779@1|root,COG0779@2|Bacteria,1RDP2@1224|Proteobacteria,2TS4E@28211|Alphaproteobacteria,2K45N@204457|Sphingomonadales	204457|Sphingomonadales	S	Required for maturation of 30S ribosomal subunits	rimP	-	-	ko:K09748	-	-	-	-	ko00000,ko03009	-	-	-	DUF150,DUF150_C
HKD2_k127_5617525_61	426117.M446_5653	2.324e-52	193.0	COG1755@1|root,COG1755@2|Bacteria,1RERZ@1224|Proteobacteria,2U77M@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Isoprenylcysteine carboxyl methyltransferase	-	-	-	ko:K16168	-	-	-	-	ko00000,ko01008	-	-	-	ICMT
HKD2_k127_5617525_28	1123267.JONN01000001_gene801	3.071e-137	445.0	COG3424@1|root,COG3424@2|Bacteria,1MUDX@1224|Proteobacteria,2TRTX@28211|Alphaproteobacteria,2K1FI@204457|Sphingomonadales	204457|Sphingomonadales	Q	Chalcone and stilbene synthases, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	Chal_sti_synt_C,Chal_sti_synt_N
HKD2_k127_5617525_26	194867.ALBQ01000022_gene3472	1.262e-138	456.0	COG2133@1|root,COG2133@2|Bacteria,1MV2E@1224|Proteobacteria,2TR47@28211|Alphaproteobacteria,2K0QG@204457|Sphingomonadales	204457|Sphingomonadales	G	glucose sorbosone	-	-	-	-	-	-	-	-	-	-	-	-	GSDH
HKD2_k127_5617525_36	1123267.JONN01000001_gene804	3.929e-117	380.0	COG0220@1|root,COG0220@2|Bacteria,1MUWJ@1224|Proteobacteria,2TUU9@28211|Alphaproteobacteria,2K0BM@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA	trmB	-	2.1.1.33	ko:K03439	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Methyltransf_4
HKD2_k127_5617525_8	1449076.JOOE01000003_gene3239	9.314e-222	692.0	COG0192@1|root,COG0192@2|Bacteria,1MUFQ@1224|Proteobacteria,2TR4P@28211|Alphaproteobacteria,2K02E@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme	metK	-	2.5.1.6	ko:K00789	ko00270,ko01100,ko01110,ko01230,map00270,map01100,map01110,map01230	M00034,M00035,M00368,M00609	R00177,R04771	RC00021,RC01211	ko00000,ko00001,ko00002,ko01000	-	-	-	S-AdoMet_synt_C,S-AdoMet_synt_M,S-AdoMet_synt_N
HKD2_k127_5617525_20	1123267.JONN01000001_gene808	1.833e-161	522.0	COG0815@1|root,COG0815@2|Bacteria,1MUBU@1224|Proteobacteria,2TQRC@28211|Alphaproteobacteria,2K1Y8@204457|Sphingomonadales	204457|Sphingomonadales	M	Transfers the fatty acyl group on membrane lipoproteins	lnt	-	-	ko:K03820	-	-	-	-	ko00000,ko01000	-	GT2	-	CN_hydrolase
HKD2_k127_5617525_55	383381.EH30_11555	1.691e-61	215.0	COG3565@1|root,COG3565@2|Bacteria,1RD7C@1224|Proteobacteria,2U78G@28211|Alphaproteobacteria,2K4FM@204457|Sphingomonadales	204457|Sphingomonadales	S	dioxygenase of extradiol dioxygenase family	-	-	-	ko:K06991	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_5617525_35	1123267.JONN01000001_gene809	3.07e-119	391.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TVFA@28211|Alphaproteobacteria,2K03F@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	-	-	-	-	-	-	-	-	-	CBS,CorC_HlyC
HKD2_k127_5617525_58	1123267.JONN01000001_gene810	6.201e-59	208.0	COG0319@1|root,COG0319@2|Bacteria,1MZ67@1224|Proteobacteria,2UBXV@28211|Alphaproteobacteria,2K4EE@204457|Sphingomonadales	204457|Sphingomonadales	J	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA	ybeY	-	-	ko:K07042	-	-	-	-	ko00000,ko03009	-	-	-	UPF0054
HKD2_k127_5617525_21	1335760.ASTG01000020_gene2598	2.526e-159	511.0	COG1702@1|root,COG1702@2|Bacteria,1MVDV@1224|Proteobacteria,2TRV3@28211|Alphaproteobacteria,2K21F@204457|Sphingomonadales	204457|Sphingomonadales	T	Phosphate starvation-inducible protein PhoH	-	-	-	ko:K06217	-	-	-	-	ko00000	-	-	-	PhoH
HKD2_k127_5617525_13	383381.EH30_08350	2.079e-201	634.0	COG0621@1|root,COG0621@2|Bacteria,1MURS@1224|Proteobacteria,2TQN6@28211|Alphaproteobacteria,2K1NH@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine	miaB	-	2.8.4.3	ko:K06168	-	-	R10645,R10646,R10647	RC00003,RC00980,RC03221,RC03222	ko00000,ko01000,ko03016	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_5617525_65	1030157.AFMP01000011_gene3751	3.469e-47	180.0	COG0204@1|root,COG0204@2|Bacteria,1N2DG@1224|Proteobacteria,2TT8Q@28211|Alphaproteobacteria,2K221@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyltransferase	-	-	2.3.1.51	ko:K00655	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R02241,R09381	RC00004,RC00037,RC00039	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Acyltransferase
HKD2_k127_5617525_48	627192.SLG_29410	1.418e-71	243.0	COG0735@1|root,COG0735@2|Bacteria,1RDWJ@1224|Proteobacteria,2U6ZS@28211|Alphaproteobacteria,2K3Z2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the Fur family	fur	-	-	ko:K03711	-	-	-	-	ko00000,ko03000	-	-	-	FUR
HKD2_k127_5617525_49	1123267.JONN01000001_gene815	7.732e-70	239.0	COG4957@1|root,COG4957@2|Bacteria,1RGUW@1224|Proteobacteria,2U99M@28211|Alphaproteobacteria,2K4EY@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	ROS_MUCR
HKD2_k127_5617525_70	1123267.JONN01000001_gene816	4.824e-38	155.0	COG0454@1|root,COG0456@2|Bacteria,1RIE6@1224|Proteobacteria,2UF5C@28211|Alphaproteobacteria,2K616@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase	rimI	-	2.3.1.128	ko:K03789	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_5617525_63	1123267.JONN01000001_gene817	2.924e-49	184.0	COG1214@1|root,COG1214@2|Bacteria,1MXPH@1224|Proteobacteria,2TTM2@28211|Alphaproteobacteria,2K59A@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M22	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M22
HKD2_k127_5617525_46	1123267.JONN01000001_gene866	5.331e-84	284.0	COG0694@1|root,COG0694@2|Bacteria,1MVQ1@1224|Proteobacteria,2TUD1@28211|Alphaproteobacteria,2K0IN@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0694 Thioredoxin-like proteins and domains	-	-	-	-	-	-	-	-	-	-	-	-	Nfu_N,NifU
HKD2_k127_5617525_50	1123267.JONN01000001_gene1312	2.703e-68	242.0	COG3658@1|root,COG3658@2|Bacteria,1RIG7@1224|Proteobacteria,2U9DR@28211|Alphaproteobacteria,2K5R6@204457|Sphingomonadales	204457|Sphingomonadales	C	Prokaryotic cytochrome b561	-	-	-	-	-	-	-	-	-	-	-	-	Ni_hydr_CYTB
HKD2_k127_5617525_76	1123267.JONN01000001_gene1311	1.344e-24	111.0	COG3909@1|root,COG3909@2|Bacteria,1Q594@1224|Proteobacteria,2UG98@28211|Alphaproteobacteria,2K6Z1@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C'	-	-	-	-	-	-	-	-	-	-	-	-	Cytochrom_C_2
HKD2_k127_5617525_34	1123267.JONN01000001_gene1310	5.994e-125	411.0	COG2084@1|root,COG2084@2|Bacteria,1RA7F@1224|Proteobacteria,2UVAZ@28211|Alphaproteobacteria,2K1F0@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the 3-hydroxyisobutyrate dehydrogenase family	mmsB	-	1.1.1.31	ko:K00020	ko00280,ko01100,map00280,map01100	-	R05066	RC00099	ko00000,ko00001,ko01000	-	-	-	NAD_binding_11,NAD_binding_2
HKD2_k127_5617525_31	1123267.JONN01000001_gene1309	2.355e-132	430.0	COG1024@1|root,COG1024@2|Bacteria,1MWZC@1224|Proteobacteria,2TRYS@28211|Alphaproteobacteria,2K12I@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_1
HKD2_k127_5617525_27	1502850.FG91_01011	7.782e-138	450.0	COG1024@1|root,COG1024@2|Bacteria,1MU0B@1224|Proteobacteria,2TQW3@28211|Alphaproteobacteria,2K1J0@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	4.2.1.17	ko:K01692	ko00071,ko00280,ko00281,ko00310,ko00360,ko00362,ko00380,ko00410,ko00627,ko00640,ko00650,ko00903,ko00930,ko01100,ko01110,ko01120,ko01130,ko01212,map00071,map00280,map00281,map00310,map00360,map00362,map00380,map00410,map00627,map00640,map00650,map00903,map00930,map01100,map01110,map01120,map01130,map01212	M00032,M00087	R03026,R03045,R04137,R04170,R04204,R04224,R04738,R04740,R04744,R04746,R04749,R05595,R06411,R06412,R06942,R08093	RC00831,RC00834,RC01086,RC01095,RC01098,RC01103,RC01217,RC02115	ko00000,ko00001,ko00002,ko01000	-	-	-	ECH_2
HKD2_k127_5617525_10	1123267.JONN01000001_gene1307	6.037e-216	673.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JZVG@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_5617525_60	196490.AUEZ01000034_gene2604	1.389e-55	201.0	COG0625@1|root,COG0625@2|Bacteria,1MY47@1224|Proteobacteria,2TVGA@28211|Alphaproteobacteria,3JR7D@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, C-terminal domain	attY	GO:0000302,GO:0003674,GO:0003824,GO:0004364,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0006950,GO:0006979,GO:0008150,GO:0009636,GO:0010035,GO:0016740,GO:0016765,GO:0042221,GO:0042493,GO:0042542,GO:0044424,GO:0044464,GO:0046677,GO:0050896,GO:1901700	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_3,GST_N,GST_N_2,GST_N_3
HKD2_k127_5617525_77	1219035.NT2_05_02360	3.687e-24	109.0	2EKD7@1|root,33E3H@2|Bacteria,1NBMH@1224|Proteobacteria,2UG3V@28211|Alphaproteobacteria,2K4NR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_5	1123267.JONN01000001_gene1301	6.506e-294	906.0	COG1012@1|root,COG1012@2|Bacteria,1MUHV@1224|Proteobacteria,2TSMD@28211|Alphaproteobacteria,2K04G@204457|Sphingomonadales	204457|Sphingomonadales	C	Methylmalonate-semialdehyde dehydrogenase	-	-	1.2.1.18,1.2.1.27	ko:K00140	ko00280,ko00410,ko00562,ko00640,ko01100,ko01200,map00280,map00410,map00562,map00640,map01100,map01200	M00013	R00705,R00706,R00922,R00935	RC00004,RC02723,RC02817	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_5617525_18	1123267.JONN01000001_gene1300	2.47e-175	568.0	COG2234@1|root,COG2234@2|Bacteria,1MWBX@1224|Proteobacteria,2U2RE@28211|Alphaproteobacteria,2JZWX@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD2_k127_5617525_71	627192.SLG_27380	2.146e-36	139.0	COG1734@1|root,COG1734@2|Bacteria,1MZIB@1224|Proteobacteria,2UCQA@28211|Alphaproteobacteria,2K69Z@204457|Sphingomonadales	204457|Sphingomonadales	T	Prokaryotic dksA/traR C4-type zinc finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-dskA_traR
HKD2_k127_5617525_2	1123267.JONN01000001_gene849	0.0	1054.0	COG0557@1|root,COG0557@2|Bacteria,1MUS6@1224|Proteobacteria,2TRC1@28211|Alphaproteobacteria,2K0KI@204457|Sphingomonadales	204457|Sphingomonadales	J	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs	rnr	-	-	ko:K12573	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03016,ko03019	-	-	-	RNB,S1
HKD2_k127_5617525_53	1123267.JONN01000001_gene850	4.483e-65	235.0	COG2010@1|root,COG2010@2|Bacteria,1MXXQ@1224|Proteobacteria,2U38E@28211|Alphaproteobacteria,2KCD6@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome C oxidase, cbb3-type, subunit III	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_56	1437882.AZRU01000057_gene4190	3.398e-60	216.0	COG0431@1|root,COG0431@2|Bacteria,1RAFI@1224|Proteobacteria,1S3MG@1236|Gammaproteobacteria,1YKT8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	NADPH-dependent FMN reductase	yieF	-	-	ko:K19784	-	-	-	-	ko00000	-	-	-	FMN_red
HKD2_k127_5617525_67	366602.Caul_2754	1.054e-43	163.0	COG2259@1|root,COG2259@2|Bacteria,1N072@1224|Proteobacteria,2UCXT@28211|Alphaproteobacteria,2KJ9S@204458|Caulobacterales	204458|Caulobacterales	S	PFAM DoxX family protein	-	-	-	ko:K15977	-	-	-	-	ko00000	-	-	-	DoxX
HKD2_k127_5617525_24	1123269.NX02_10205	1.475e-150	486.0	COG3844@1|root,COG3844@2|Bacteria,1MUKN@1224|Proteobacteria,2TR62@28211|Alphaproteobacteria,2K1KR@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively	kynU	-	3.7.1.3	ko:K01556	ko00380,ko01100,map00380,map01100	M00038	R00987,R02668,R03936	RC00284,RC00415	ko00000,ko00001,ko00002,ko01000	-	-	-	Aminotran_5
HKD2_k127_5617525_39	1470591.BW41_01876	1.12e-112	366.0	COG0717@1|root,COG0717@2|Bacteria,1MV2J@1224|Proteobacteria,2TSDM@28211|Alphaproteobacteria,2JZVF@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the dCTP deaminase family	dcd	-	3.5.4.13	ko:K01494	ko00240,ko01100,map00240,map01100	M00053	R00568,R02325	RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	dUTPase
HKD2_k127_5617525_9	685778.AORL01000001_gene165	6.358e-217	684.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2K1TQ@204457|Sphingomonadales	204457|Sphingomonadales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_5617525_33	1219049.SP5_069_00620	5.013e-127	425.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K13N@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative peptidoglycan binding domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_5617525_7	1123267.JONN01000001_gene857	7.422e-241	752.0	COG1012@1|root,COG1012@2|Bacteria,1MV2I@1224|Proteobacteria,2TU8S@28211|Alphaproteobacteria,2K13M@204457|Sphingomonadales	204457|Sphingomonadales	C	Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate	astD	-	1.2.1.71	ko:K06447	ko00330,ko01100,map00330,map01100	-	R05049	RC00080	ko00000,ko00001,ko01000	-	-	-	Aldedh
HKD2_k127_5617525_15	1123267.JONN01000001_gene858	1.106e-191	608.0	COG0397@1|root,COG0397@2|Bacteria,1MVK3@1224|Proteobacteria,2TT84@28211|Alphaproteobacteria,2JZUT@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, YdiU/UPF0061 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0061
HKD2_k127_5617525_66	1123267.JONN01000001_gene860	1.323e-45	173.0	COG1999@1|root,COG1999@2|Bacteria,1RHJ8@1224|Proteobacteria,2U0Q3@28211|Alphaproteobacteria,2KD2A@204457|Sphingomonadales	204457|Sphingomonadales	S	SCO1/SenC	-	-	-	ko:K07152	-	-	-	-	ko00000,ko03029	-	-	-	SCO1-SenC
HKD2_k127_5617525_43	685778.AORL01000010_gene2855	4.981e-93	321.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2U6NR@28211|Alphaproteobacteria,2K2XA@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase-like ATPases	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,PAS_8
HKD2_k127_5617525_19	627192.SLG_27150	6.89e-173	554.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2KCJR@204457|Sphingomonadales	204457|Sphingomonadales	T	Sigma-54 interaction domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_5617525_25	745310.G432_10385	1.193e-147	480.0	COG0845@1|root,COG0845@2|Bacteria,1NGI2@1224|Proteobacteria,2U1S9@28211|Alphaproteobacteria,2K0MG@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K02005	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3
HKD2_k127_5617525_38	1449076.JOOE01000001_gene2749	2.048e-115	374.0	COG1136@1|root,COG1136@2|Bacteria,1MU45@1224|Proteobacteria,2VEU2@28211|Alphaproteobacteria,2K027@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC transporter	-	-	-	ko:K02003	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC_tran
HKD2_k127_5617525_4	745310.G432_10375	1.349e-315	987.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,2U1KH@28211|Alphaproteobacteria,2K128@204457|Sphingomonadales	204457|Sphingomonadales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_5617525_3	745310.G432_10375	5.268e-320	999.0	COG0577@1|root,COG0577@2|Bacteria,1NREW@1224|Proteobacteria,2U1KH@28211|Alphaproteobacteria,2K128@204457|Sphingomonadales	204457|Sphingomonadales	V	MacB-like periplasmic core domain	-	-	-	ko:K02004	-	M00258	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	FtsX,MacB_PCD
HKD2_k127_5617525_41	1442599.JAAN01000042_gene3060	4.801e-100	331.0	COG1396@1|root,COG1396@2|Bacteria,1R6PS@1224|Proteobacteria,1T24B@1236|Gammaproteobacteria,1X5S2@135614|Xanthomonadales	135614|Xanthomonadales	K	Cro/C1-type HTH DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2,HTH_31
HKD2_k127_5617525_14	1123073.KB899241_gene2159	5.241e-201	646.0	COG1680@1|root,COG1680@2|Bacteria,1PQ2Z@1224|Proteobacteria,1SYR1@1236|Gammaproteobacteria,1XCSI@135614|Xanthomonadales	135614|Xanthomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_5617525_29	1123073.KB899241_gene2160	4.68e-135	445.0	COG4948@1|root,COG4948@2|Bacteria,1MW76@1224|Proteobacteria,1RMKS@1236|Gammaproteobacteria,1XCGI@135614|Xanthomonadales	135614|Xanthomonadales	M	Mandelate racemase / muconate lactonizing enzyme, C-terminal domain	-	-	-	-	-	-	-	-	-	-	-	-	MR_MLE_C,MR_MLE_N
HKD2_k127_5617525_17	1123073.KB899241_gene2161	9.858e-178	567.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,1RM8P@1236|Gammaproteobacteria,1X5T0@135614|Xanthomonadales	135614|Xanthomonadales	E	POT family	-	-	-	-	-	-	-	-	-	-	-	-	PTR2
HKD2_k127_5617525_22	1174684.EBMC1_15187	9.37e-157	504.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2K6CQ@204457|Sphingomonadales	204457|Sphingomonadales	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_5617525_12	1144305.PMI02_02324	3.774e-205	666.0	COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U2KS@28211|Alphaproteobacteria,2KDKA@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB-dependent receptor plug	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_5617525_23	1502850.FG91_00618	8.56e-155	498.0	COG3367@1|root,COG3367@2|Bacteria,1MVEX@1224|Proteobacteria,2TS0Y@28211|Alphaproteobacteria,2K06Y@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1611_N) Rossmann-like domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF1611,DUF1611_N
HKD2_k127_5617525_44	1161401.ASJA01000005_gene2472	5.483e-91	313.0	COG2367@1|root,COG2367@2|Bacteria,1NMW4@1224|Proteobacteria,2VEG4@28211|Alphaproteobacteria,440J3@69657|Hyphomonadaceae	28211|Alphaproteobacteria	V	Beta-lactamase enzyme family	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase2
HKD2_k127_5617525_32	1120705.FG95_00723	5.727e-130	426.0	COG3949@1|root,COG3949@2|Bacteria,1QAYU@1224|Proteobacteria,2U6DV@28211|Alphaproteobacteria,2K0X7@204457|Sphingomonadales	204457|Sphingomonadales	S	Membrane	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5617525_11	1122137.AQXF01000002_gene664	2.34e-215	680.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria	1224|Proteobacteria	V	COG1680 Beta-lactamase class C and other penicillin binding proteins	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HKD2_k127_5617525_73	1549858.MC45_06855	5.844e-28	116.0	COG4456@1|root,COG4456@2|Bacteria,1N7E4@1224|Proteobacteria,2UFX5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antidote-toxin recognition MazE, bacterial antitoxin	-	-	-	ko:K18829	-	-	-	-	ko00000,ko02048	-	-	-	MazE_antitoxin
HKD2_k127_5617525_54	1549858.MC45_06850	6.401e-62	215.0	COG1487@1|root,COG1487@2|Bacteria,1MZB6@1224|Proteobacteria,2U9C1@28211|Alphaproteobacteria,2K4ME@204457|Sphingomonadales	204457|Sphingomonadales	S	Toxic component of a toxin-antitoxin (TA) module. An RNase	vapC_2	-	-	ko:K18828	-	-	-	-	ko00000,ko01000,ko02048,ko03016	-	-	-	PIN
HKD2_k127_5617525_75	983920.Y88_1620	5.878e-25	104.0	2D16E@1|root,32TA0@2|Bacteria,1MZ7W@1224|Proteobacteria,2TVWX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Motility quorum-sensing regulator, toxin of MqsA	-	-	-	ko:K13651	-	-	-	-	ko00000,ko02048	-	-	-	MqsR_toxin
HKD2_k127_5617525_81	983920.Y88_1621	2.529e-18	88.0	COG2944@1|root,COG2944@2|Bacteria,1QV9M@1224|Proteobacteria,2USEH@28211|Alphaproteobacteria,2KBCJ@204457|Sphingomonadales	204457|Sphingomonadales	K	Antitoxin component of bacterial toxin-antitoxin system, MqsA	-	-	-	ko:K13655	-	-	-	-	ko00000,ko02048,ko03000	-	-	-	MqsA_antitoxin
HKD2_k127_5617525_80	983920.Y88_3854	6.187e-20	91.0	COG2944@1|root,COG2944@2|Bacteria,1QV9M@1224|Proteobacteria,2USEH@28211|Alphaproteobacteria,2KA8X@204457|Sphingomonadales	204457|Sphingomonadales	K	Antitoxin component of bacterial toxin-antitoxin system, MqsA	-	-	-	-	-	-	-	-	-	-	-	-	MqsA_antitoxin
HKD2_k127_5745577_6	1123267.JONN01000001_gene2288	1.233e-38	152.0	COG2987@1|root,COG2987@2|Bacteria,1MU4W@1224|Proteobacteria,2TSJR@28211|Alphaproteobacteria,2K2BT@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate	hutU	-	4.2.1.49	ko:K01712	ko00340,ko01100,map00340,map01100	M00045	R02914	RC00804	ko00000,ko00001,ko00002,ko01000	-	-	-	Urocanase,Urocanase_C,Urocanase_N
HKD2_k127_5745577_12	1124983.PFLCHA0_c48910	5.465e-05	50.0	COG2141@1|root,COG2141@2|Bacteria,1RGXC@1224|Proteobacteria,1SHMT@1236|Gammaproteobacteria,1YPQB@136843|Pseudomonas fluorescens group	1236|Gammaproteobacteria	C	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5745577_2	1502851.FG93_00408	6.618e-129	423.0	COG1228@1|root,COG1228@2|Bacteria,1MUYR@1224|Proteobacteria,2TSA1@28211|Alphaproteobacteria,3JVJX@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	Q	imidazolonepropionase activity	hutI	-	3.5.2.7	ko:K01468	ko00340,ko01100,map00340,map01100	M00045	R02288	RC00683	ko00000,ko00001,ko00002,ko01000	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_5745577_4	1123267.JONN01000001_gene2285	9.808e-116	383.0	COG0010@1|root,COG0010@2|Bacteria,1MVFH@1224|Proteobacteria,2TQSZ@28211|Alphaproteobacteria,2K3CB@204457|Sphingomonadales	204457|Sphingomonadales	E	Arginase family	-	-	3.5.3.11	ko:K01480	ko00330,ko01100,map00330,map01100	M00133	R01157	RC00024,RC00329	ko00000,ko00001,ko00002,ko01000	-	-	-	Arginase
HKD2_k127_5745577_5	395965.Msil_0869	1.757e-65	229.0	COG3145@1|root,COG3145@2|Bacteria,1RDBK@1224|Proteobacteria,2U808@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Alkylated DNA repair protein	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_2
HKD2_k127_5745577_1	1449076.JOOE01000004_gene70	1.634e-140	454.0	COG1793@1|root,COG1793@2|Bacteria,1R4SI@1224|Proteobacteria,2U213@28211|Alphaproteobacteria,2K3AE@204457|Sphingomonadales	204457|Sphingomonadales	L	ATP dependent DNA ligase C terminal region	-	-	-	-	-	-	-	-	-	-	-	-	DNA_ligase_A_C,DNA_ligase_A_M
HKD2_k127_5745577_0	1174684.EBMC1_15679	4.457e-151	486.0	COG0501@1|root,COG0501@2|Bacteria,1MUXT@1224|Proteobacteria,2TVI9@28211|Alphaproteobacteria,2K2GU@204457|Sphingomonadales	204457|Sphingomonadales	O	CAAX prenyl protease N-terminal, five membrane helices	-	-	3.4.24.84	ko:K06013	ko00900,ko01130,map00900,map01130	-	R09845	RC00141	ko00000,ko00001,ko01000,ko01002,ko04147	-	-	-	Peptidase_M48,Peptidase_M48_N
HKD2_k127_5745577_3	1379701.JPJC01000112_gene500	4.275e-125	415.0	COG0840@1|root,COG0840@2|Bacteria,1MU9B@1224|Proteobacteria,2TQR7@28211|Alphaproteobacteria,2K1AE@204457|Sphingomonadales	204457|Sphingomonadales	NT	chemotaxis	-	-	-	ko:K03406	ko02020,ko02030,map02020,map02030	-	-	-	ko00000,ko00001,ko02035	-	-	-	MCPsignal
HKD2_k127_5745577_7	766499.C357_14541	2.467e-29	120.0	COG3177@1|root,COG3177@2|Bacteria,1MVW0@1224|Proteobacteria,2TU9A@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Filamentation induced by cAMP protein fic	-	-	-	-	-	-	-	-	-	-	-	-	Fic
HKD2_k127_5745577_9	598659.NAMH_1184	1.234e-10	66.0	2AY0S@1|root,31Q2B@2|Bacteria,1QMQY@1224|Proteobacteria,42SY0@68525|delta/epsilon subdivisions,2YPGA@29547|Epsilonproteobacteria	29547|Epsilonproteobacteria	S	Bacteriophage replication gene A protein (GPA)	-	-	-	-	-	-	-	-	-	-	-	-	Phage_GPA
HKD2_k127_5745577_10	1150469.RSPPHO_02107	4.314e-08	55.0	COG2352@1|root,COG2352@2|Bacteria,1MUD5@1224|Proteobacteria,2TR6F@28211|Alphaproteobacteria,2JR6A@204441|Rhodospirillales	204441|Rhodospirillales	C	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle	ppc	-	4.1.1.31	ko:K01595	ko00620,ko00680,ko00710,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00710,map00720,map01100,map01120,map01200	M00168,M00170,M00171,M00172,M00173,M00346,M00374	R00345	RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPcase
HKD2_k127_5745577_8	1121129.KB903364_gene2954	4.175e-14	73.0	2AHEJ@1|root,317RR@2|Bacteria,4P93N@976|Bacteroidetes,2FZC5@200643|Bacteroidia	976|Bacteroidetes	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5745577_11	926692.AZYG01000050_gene174	1.719e-05	46.0	arCOG05874@1|root,2ZJ01@2|Bacteria,1V450@1239|Firmicutes,24NM6@186801|Clostridia	186801|Clostridia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5753705_42	1123267.JONN01000002_gene146	2.368e-11	63.0	COG2919@1|root,COG2919@2|Bacteria,1NGSW@1224|Proteobacteria,2UJYE@28211|Alphaproteobacteria,2K7B8@204457|Sphingomonadales	204457|Sphingomonadales	D	Septum formation initiator	-	-	-	-	-	-	-	-	-	-	-	-	DivIC
HKD2_k127_5753705_39	1214101.BN159_0538	1.332e-19	93.0	COG2329@1|root,COG2329@2|Bacteria,2I6PF@201174|Actinobacteria	201174|Actinobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5753705_11	1123267.JONN01000002_gene147	4.525e-182	574.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRSS@28211|Alphaproteobacteria,2K0VG@204457|Sphingomonadales	204457|Sphingomonadales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhA	-	1.2.4.1	ko:K00161	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_5753705_6	194867.ALBQ01000004_gene3524	7.961e-223	703.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRMR@28211|Alphaproteobacteria,2JZYC@204457|Sphingomonadales	204457|Sphingomonadales	C	The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)	pdhB	-	1.2.4.1	ko:K00162	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_lipoyl,Transket_pyr,Transketolase_C
HKD2_k127_5753705_38	745310.G432_13795	7.415e-24	109.0	COG1562@1|root,COG1562@2|Bacteria,1N5V2@1224|Proteobacteria,2UBZJ@28211|Alphaproteobacteria,2K4II@204457|Sphingomonadales	204457|Sphingomonadales	I	ergosterol biosynthetic process	-	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_5753705_3	1123267.JONN01000001_gene968	3.916e-230	719.0	COG1206@1|root,COG1206@2|Bacteria,1MWNQ@1224|Proteobacteria,2TR6M@28211|Alphaproteobacteria,2K17V@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs	trmFO	-	2.1.1.74	ko:K04094	-	-	-	-	ko00000,ko01000,ko03016,ko03036	-	-	-	GIDA
HKD2_k127_5753705_37	1525715.IX54_04705	7.92e-27	115.0	COG0346@1|root,COG0346@2|Bacteria,1RH79@1224|Proteobacteria,2UAPG@28211|Alphaproteobacteria,2PX1V@265|Paracoccus	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Glyoxalase
HKD2_k127_5753705_27	1090319.KE386571_gene1039	2.97e-55	197.0	COG5483@1|root,COG5483@2|Bacteria,1N3XQ@1224|Proteobacteria,2UCV7@28211|Alphaproteobacteria,2K4V4@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function, DUF488	-	-	-	-	-	-	-	-	-	-	-	-	DUF488
HKD2_k127_5753705_36	194867.ALBQ01000040_gene3154	3.706e-27	121.0	COG3652@1|root,COG3652@2|Bacteria,1N6QU@1224|Proteobacteria,2UF70@28211|Alphaproteobacteria,2K4I4@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_5753705_26	1123267.JONN01000002_gene337	6.488e-59	207.0	COG5622@1|root,COG5622@2|Bacteria,1RIEJ@1224|Proteobacteria,2U7UE@28211|Alphaproteobacteria,2K400@204457|Sphingomonadales	204457|Sphingomonadales	N	Protein required for attachment to host cells	-	-	-	-	-	-	-	-	-	-	-	-	Host_attach
HKD2_k127_5753705_0	1123267.JONN01000002_gene338	0.0	1423.0	COG0188@1|root,COG0188@2|Bacteria,1MUGG@1224|Proteobacteria,2TSPQ@28211|Alphaproteobacteria,2K02J@204457|Sphingomonadales	204457|Sphingomonadales	L	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner	gyrA	-	5.99.1.3	ko:K02469	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_5753705_30	685778.AORL01000021_gene1019	7.391e-45	179.0	COG0457@1|root,COG0457@2|Bacteria,1Q7UR@1224|Proteobacteria,2U8BX@28211|Alphaproteobacteria,2K0N1@204457|Sphingomonadales	204457|Sphingomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16
HKD2_k127_5753705_22	1123267.JONN01000001_gene1078	7.119e-90	316.0	COG0642@1|root,COG5330@1|root,COG2205@2|Bacteria,COG5330@2|Bacteria,1R692@1224|Proteobacteria,2U480@28211|Alphaproteobacteria,2K18H@204457|Sphingomonadales	204457|Sphingomonadales	T	His Kinase A (phosphoacceptor) domain	-	-	-	-	-	-	-	-	-	-	-	-	HisKA
HKD2_k127_5753705_7	1123267.JONN01000001_gene1082	1.762e-214	674.0	COG2234@1|root,COG2234@2|Bacteria,1NE83@1224|Proteobacteria,2TSF8@28211|Alphaproteobacteria,2K0KQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M28	-	-	-	-	-	-	-	-	-	-	-	-	PA,Peptidase_M28
HKD2_k127_5753705_10	1123267.JONN01000001_gene1083	3.671e-184	580.0	COG1533@1|root,COG1533@2|Bacteria,1MW0H@1224|Proteobacteria,2TQQB@28211|Alphaproteobacteria,2K118@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA repair photolyase	-	-	-	-	-	-	-	-	-	-	-	-	Radical_SAM
HKD2_k127_5753705_29	1123267.JONN01000001_gene1703	4.512e-53	198.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria,2K90M@204457|Sphingomonadales	204457|Sphingomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_5753705_15	194867.ALBQ01000018_gene2591	4.9e-133	445.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2U35U@28211|Alphaproteobacteria,2K136@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD2_k127_5753705_28	1123267.JONN01000001_gene1087	2.186e-54	199.0	COG1573@1|root,COG1573@2|Bacteria,1NC19@1224|Proteobacteria,2UFEQ@28211|Alphaproteobacteria,2K5KQ@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase	-	-	3.2.2.27	ko:K21929	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UDG
HKD2_k127_5753705_2	1030157.AFMP01000041_gene1242	3.484e-288	891.0	COG0644@1|root,COG2440@1|root,COG0644@2|Bacteria,COG2440@2|Bacteria,1MVU6@1224|Proteobacteria,2TS0R@28211|Alphaproteobacteria,2K0PG@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein-ubiquinone oxidoreductase	-	-	1.5.5.1	ko:K00311	-	-	-	-	ko00000,ko01000	-	-	-	ETF_QO,FAD_binding_2,NAD_binding_8
HKD2_k127_5753705_20	1123267.JONN01000001_gene1089	5.151e-119	405.0	COG0457@1|root,COG0457@2|Bacteria,1MYB8@1224|Proteobacteria,2TQV5@28211|Alphaproteobacteria,2K0KS@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_14,TPR_16,TPR_19
HKD2_k127_5753705_21	1123267.JONN01000001_gene1090	3.165e-90	304.0	COG1947@1|root,COG1947@2|Bacteria,1MVU3@1224|Proteobacteria,2TUFV@28211|Alphaproteobacteria,2K1QE@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol	ispE	-	2.7.1.148	ko:K00919	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05634	RC00002,RC01439	ko00000,ko00001,ko00002,ko01000	-	-	-	GHMP_kinases_C,GHMP_kinases_N
HKD2_k127_5753705_12	1123267.JONN01000001_gene1091	2.504e-180	580.0	COG0062@1|root,COG0063@1|root,COG0062@2|Bacteria,COG0063@2|Bacteria,1MU1Q@1224|Proteobacteria,2TT58@28211|Alphaproteobacteria,2K1P3@204457|Sphingomonadales	204457|Sphingomonadales	G	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	-	-	-	-	-	-	-	-	-	-	Carb_kinase,YjeF_N
HKD2_k127_5753705_13	1123267.JONN01000001_gene1092	9.026e-166	531.0	COG2265@1|root,COG2265@2|Bacteria,1MV3A@1224|Proteobacteria,2TR40@28211|Alphaproteobacteria,2K0YT@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family	-	-	2.1.1.190	ko:K03215	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	tRNA_U5-meth_tr
HKD2_k127_5753705_35	1123267.JONN01000001_gene1093	1.691e-36	144.0	COG5331@1|root,COG5331@2|Bacteria,1N0MD@1224|Proteobacteria,2U9ZR@28211|Alphaproteobacteria,2K571@204457|Sphingomonadales	204457|Sphingomonadales	S	MAPEG family	-	-	-	-	-	-	-	-	-	-	-	-	MAPEG
HKD2_k127_5753705_19	1234364.AMSF01000082_gene2993	7.394e-120	402.0	COG0477@1|root,COG2814@2|Bacteria,1QTW0@1224|Proteobacteria,1T2CZ@1236|Gammaproteobacteria	1236|Gammaproteobacteria	EGP	Major Facilitator	proP	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	iJN746.PP_2703	MFS_1,Sugar_tr
HKD2_k127_5753705_9	1123267.JONN01000001_gene1095	2.636e-197	619.0	COG1899@1|root,COG1899@2|Bacteria,1MVC6@1224|Proteobacteria,2TTRW@28211|Alphaproteobacteria,2K1R2@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the deoxyhypusine synthase family	-	-	2.5.1.46	ko:K00809	-	-	-	-	ko00000,ko01000	-	-	-	DS
HKD2_k127_5753705_8	1123267.JONN01000001_gene1096	2.382e-208	656.0	COG0019@1|root,COG0019@2|Bacteria,1MZ7Y@1224|Proteobacteria,2TSKB@28211|Alphaproteobacteria,2K02Y@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the Orn Lys Arg decarboxylase class-II family	speF	-	4.1.1.17	ko:K01581	ko00330,ko00480,ko01100,ko01110,ko01130,map00330,map00480,map01100,map01110,map01130	M00134	R00670	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_5753705_24	1463936.JOJI01000030_gene4538	1.054e-84	287.0	COG1794@1|root,COG1794@2|Bacteria,2H7J9@201174|Actinobacteria	201174|Actinobacteria	M	aspartate racemase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Glu_race
HKD2_k127_5753705_18	1123267.JONN01000001_gene1097	2.72e-123	403.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K27R@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_5753705_16	1123267.JONN01000001_gene1100	4.592e-131	419.0	COG2945@1|root,COG2945@2|Bacteria,1MUDY@1224|Proteobacteria,2TRMI@28211|Alphaproteobacteria,2JZVR@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha Beta	-	-	-	ko:K07018	-	-	-	-	ko00000	-	-	-	Hydrolase_4,Peptidase_S15
HKD2_k127_5753705_17	1123267.JONN01000001_gene1101	9.667e-131	428.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2JZZX@204457|Sphingomonadales	204457|Sphingomonadales	E	overlaps another CDS with the same product name	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_5753705_14	1123267.JONN01000001_gene1102	2.1e-139	456.0	COG1104@1|root,COG1104@2|Bacteria,1MU1C@1224|Proteobacteria,2TSQE@28211|Alphaproteobacteria,2K05P@204457|Sphingomonadales	204457|Sphingomonadales	E	overlaps another CDS with the same product name	-	-	2.8.1.7	ko:K04487	ko00730,ko01100,ko04122,map00730,map01100,map04122	-	R07460,R11528,R11529	RC01789,RC02313	ko00000,ko00001,ko01000,ko02048,ko03016,ko03029	-	-	-	Aminotran_5
HKD2_k127_5753705_32	685778.AORL01000021_gene386	1.785e-40	152.0	COG0633@1|root,COG0633@2|Bacteria,1RHDC@1224|Proteobacteria,2U97J@28211|Alphaproteobacteria,2K5X1@204457|Sphingomonadales	204457|Sphingomonadales	C	Ferredoxin	-	-	-	ko:K04755	-	-	-	-	ko00000	-	-	-	Fer2
HKD2_k127_5753705_31	1470591.BW41_02646	2.972e-42	165.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UJHN@28211|Alphaproteobacteria,2KDA1@204457|Sphingomonadales	204457|Sphingomonadales	DTZ	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD2_k127_5753705_34	392499.Swit_2148	1.425e-36	147.0	2E5AF@1|root,3302M@2|Bacteria,1NEU4@1224|Proteobacteria,2UI3N@28211|Alphaproteobacteria,2K5G5@204457|Sphingomonadales	204457|Sphingomonadales	S	EF hand	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD2_k127_5753705_4	1123267.JONN01000001_gene1104	2.59e-227	715.0	COG2812@1|root,COG2812@2|Bacteria,1MVCK@1224|Proteobacteria,2TRPB@28211|Alphaproteobacteria,2K0MV@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity	dnaX	-	2.7.7.7	ko:K02343	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2,DNA_pol3_gamma3,DUF3646
HKD2_k127_5753705_33	1123267.JONN01000001_gene1105	1.811e-40	153.0	COG0718@1|root,COG0718@2|Bacteria,1RGZD@1224|Proteobacteria,2UBQB@28211|Alphaproteobacteria,2K5JW@204457|Sphingomonadales	204457|Sphingomonadales	S	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection	-	-	-	ko:K09747	-	-	-	-	ko00000	-	-	-	YbaB_DNA_bd
HKD2_k127_5753705_5	1123267.JONN01000001_gene1106	2.279e-225	711.0	COG0318@1|root,COG0318@2|Bacteria,1MUMC@1224|Proteobacteria,2TR96@28211|Alphaproteobacteria,2K0TE@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	6.2.1.44	ko:K00666,ko:K20034	ko00920,map00920	-	R10820	RC00004,RC00014	ko00000,ko00001,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_5753705_1	194867.ALBQ01000023_gene3222	0.0	1024.0	COG0488@1|root,COG0488@2|Bacteria,1MU37@1224|Proteobacteria,2TS7G@28211|Alphaproteobacteria,2K0YK@204457|Sphingomonadales	204457|Sphingomonadales	S	ABC transporter	-	-	-	-	-	-	-	-	-	-	-	-	ABC_tran,ABC_tran_Xtn
HKD2_k127_5753705_23	1030157.AFMP01000042_gene1297	1.627e-86	297.0	COG0697@1|root,COG0697@2|Bacteria,1MZXM@1224|Proteobacteria,2TSZM@28211|Alphaproteobacteria,2K256@204457|Sphingomonadales	204457|Sphingomonadales	EG	of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_5753705_40	392499.Swit_2479	1.585e-18	92.0	2E3QV@1|root,32YNP@2|Bacteria,1N938@1224|Proteobacteria,2UFTE@28211|Alphaproteobacteria,2K7BQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1905)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1905
HKD2_k127_5753705_25	1122612.AUBA01000008_gene2305	8.805e-76	269.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K26Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16
HKD2_k127_5877932_0	1088721.NSU_0627	5.246e-154	495.0	COG0305@1|root,COG0305@2|Bacteria,1MUG9@1224|Proteobacteria,2TSF9@28211|Alphaproteobacteria,2K1TQ@204457|Sphingomonadales	204457|Sphingomonadales	L	it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins	dnaB	-	3.6.4.12	ko:K02314	ko03030,ko04112,map03030,map04112	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	DnaB,DnaB_C
HKD2_k127_5877932_1	279238.Saro_0143	8.938e-85	285.0	COG5328@1|root,COG5328@2|Bacteria,1RA93@1224|Proteobacteria,2U741@28211|Alphaproteobacteria,2K40E@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0262 family	-	-	-	-	-	-	-	-	-	-	-	-	UPF0262
HKD2_k127_5877932_2	158500.BV97_00182	2.448e-33	131.0	COG3757@1|root,COG3757@2|Bacteria,1N792@1224|Proteobacteria,2TVI6@28211|Alphaproteobacteria,2K58D@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl hydrolases family 25	-	-	-	ko:K07273	-	-	-	-	ko00000	-	-	-	Glyco_hydro_25
HKD2_k127_5921091_18	1123267.JONN01000001_gene451	1.615e-189	599.0	COG0849@1|root,COG0849@2|Bacteria,1MUSR@1224|Proteobacteria,2TQZB@28211|Alphaproteobacteria,2K082@204457|Sphingomonadales	204457|Sphingomonadales	D	Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring	ftsA	-	-	ko:K03590	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036,ko04812	-	-	-	FtsA,SHS2_FTSA
HKD2_k127_5921091_49	1123267.JONN01000001_gene450	2.022e-102	343.0	COG1589@1|root,COG1589@2|Bacteria,1MY1Q@1224|Proteobacteria,2TQPU@28211|Alphaproteobacteria,2K1JE@204457|Sphingomonadales	204457|Sphingomonadales	D	Cell division protein FtsQ	ftsQ	-	-	ko:K03589	ko04112,map04112	-	-	-	ko00000,ko00001,ko03036	-	-	-	FtsQ,POTRA_1
HKD2_k127_5921091_26	1123267.JONN01000001_gene449	2.742e-161	512.0	COG1181@1|root,COG1181@2|Bacteria,1MUTB@1224|Proteobacteria,2TREC@28211|Alphaproteobacteria,2K0W3@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation	ddl	-	6.3.2.4	ko:K01921	ko00473,ko00550,ko01100,ko01502,map00473,map00550,map01100,map01502	-	R01150	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Dala_Dala_lig_C,Dala_Dala_lig_N
HKD2_k127_5921091_36	1549858.MC45_09230	9.997e-143	457.0	COG0812@1|root,COG0812@2|Bacteria,1MXDH@1224|Proteobacteria,2TRQR@28211|Alphaproteobacteria,2K0QA@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation	murB	-	1.3.1.98	ko:K00075	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R03191,R03192	RC02639	ko00000,ko00001,ko01000,ko01011	-	-	-	FAD_binding_4,MurB_C
HKD2_k127_5921091_10	1123267.JONN01000001_gene447	5.573e-235	735.0	COG0773@1|root,COG0773@2|Bacteria,1MV68@1224|Proteobacteria,2TRT0@28211|Alphaproteobacteria,2K03S@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the MurCDEF family	murC	-	6.3.2.8	ko:K01924	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R03193	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_5921091_22	1123267.JONN01000001_gene446	2.976e-168	539.0	COG0707@1|root,COG0707@2|Bacteria,1MVIB@1224|Proteobacteria,2TSEY@28211|Alphaproteobacteria,2K0YF@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)	murG	-	2.4.1.227	ko:K02563	ko00550,ko01100,ko01502,ko04112,map00550,map01100,map01502,map04112	-	R05032,R05662	RC00005,RC00049	ko00000,ko00001,ko01000,ko01011	-	GT28	-	Glyco_tran_28_C,Glyco_transf_28
HKD2_k127_5921091_17	1123267.JONN01000001_gene445	2.523e-190	602.0	COG0772@1|root,COG0772@2|Bacteria,1MVDB@1224|Proteobacteria,2TQSA@28211|Alphaproteobacteria,2K0IS@204457|Sphingomonadales	204457|Sphingomonadales	D	Belongs to the SEDS family	ftsW	-	-	ko:K03588	ko04112,map04112	-	-	-	ko00000,ko00001,ko02000,ko03036	2.A.103.1	-	-	FTSW_RODA_SPOVE
HKD2_k127_5921091_24	452662.SJA_C1-27950	2.281e-165	533.0	COG0771@1|root,COG0771@2|Bacteria,1MVYD@1224|Proteobacteria,2TTE8@28211|Alphaproteobacteria,2K1GM@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)	murD	-	6.3.2.9	ko:K01925	ko00471,ko00550,ko01100,map00471,map00550,map01100	-	R02783	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase_C,Mur_ligase_M
HKD2_k127_5921091_32	517722.AEUE01000004_gene794	4.486e-147	475.0	COG0472@1|root,COG0472@2|Bacteria,1MUTK@1224|Proteobacteria,2TRUG@28211|Alphaproteobacteria,2K18Y@204457|Sphingomonadales	204457|Sphingomonadales	M	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan	mraY	-	2.7.8.13	ko:K01000	ko00550,ko01100,ko01502,map00550,map01100,map01502	-	R05629,R05630	RC00002,RC02753	ko00000,ko00001,ko01000,ko01011	9.B.146	-	-	Glycos_transf_4,MraY_sig1
HKD2_k127_5921091_15	1123267.JONN01000001_gene442	1.474e-195	620.0	COG0770@1|root,COG0770@2|Bacteria,1QTSF@1224|Proteobacteria,2TR0Q@28211|Alphaproteobacteria,2K1N2@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein	murF	-	6.3.2.10	ko:K01929	ko00300,ko00550,ko01100,ko01502,map00300,map00550,map01100,map01502	-	R04573,R04617	RC00064,RC00141	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_5921091_14	1123267.JONN01000001_gene441	1.491e-213	674.0	COG0769@1|root,COG0769@2|Bacteria,1MU6P@1224|Proteobacteria,2TVXI@28211|Alphaproteobacteria,2K12F@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan	murE	-	6.3.2.13	ko:K01928	ko00300,ko00550,map00300,map00550	-	R02788	RC00064,RC00090	ko00000,ko00001,ko01000,ko01011	-	-	-	Mur_ligase,Mur_ligase_C,Mur_ligase_M
HKD2_k127_5921091_8	1123267.JONN01000001_gene440	4.349e-244	767.0	COG0768@1|root,COG0768@2|Bacteria,1MUNY@1224|Proteobacteria,2TSHQ@28211|Alphaproteobacteria,2K0Y2@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell division protein FtsI penicillin-binding protein	ftsI	-	3.4.16.4	ko:K03587	ko00550,ko01501,map00550,map01501	-	-	-	ko00000,ko00001,ko01000,ko01011,ko03036	-	-	-	PBP_dimer,Transpeptidase
HKD2_k127_5921091_82	1123267.JONN01000001_gene439	5.757e-34	142.0	2AK00@1|root,31APD@2|Bacteria,1NHHT@1224|Proteobacteria,2UM7C@28211|Alphaproteobacteria,2K3BJ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_44	392499.Swit_3955	7.483e-121	396.0	COG0275@1|root,COG0275@2|Bacteria,1MUT4@1224|Proteobacteria,2TRQA@28211|Alphaproteobacteria,2K178@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA	rsmH	-	2.1.1.199	ko:K03438	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltransf_5
HKD2_k127_5921091_62	1123267.JONN01000001_gene437	9.125e-74	251.0	COG2001@1|root,COG2001@2|Bacteria,1RC62@1224|Proteobacteria,2U8RU@28211|Alphaproteobacteria,2K3M2@204457|Sphingomonadales	204457|Sphingomonadales	K	Belongs to the MraZ family	-	-	-	ko:K03925	-	-	-	-	ko00000	-	-	-	MraZ
HKD2_k127_5921091_79	1123267.JONN01000001_gene436	7.352e-45	171.0	COG3225@1|root,COG3225@2|Bacteria,1NC9C@1224|Proteobacteria,2UH50@28211|Alphaproteobacteria,2K6BU@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	ABC_transp_aux
HKD2_k127_5921091_94	1123267.JONN01000001_gene434	7.853e-20	93.0	2AKTW@1|root,31BKY@2|Bacteria,1NYMF@1224|Proteobacteria,2UTU9@28211|Alphaproteobacteria,2K5IB@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_50	1123240.ATVO01000003_gene241	8.913e-96	334.0	COG1680@1|root,COG1680@2|Bacteria,1R8N7@1224|Proteobacteria,2UCNR@28211|Alphaproteobacteria,2K0VY@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_5921091_2	1123267.JONN01000001_gene433	0.0	1200.0	COG0046@1|root,COG0046@2|Bacteria,1MYN4@1224|Proteobacteria,2TRGM@28211|Alphaproteobacteria,2K25A@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purL	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_5921091_86	1449049.JONW01000002_gene2562	1.14e-27	120.0	COG0537@1|root,COG1073@1|root,COG0537@2|Bacteria,COG1073@2|Bacteria,1RC0W@1224|Proteobacteria,2U6C5@28211|Alphaproteobacteria	28211|Alphaproteobacteria	FG	alpha, beta	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_3,Abhydrolase_6,HIT,Hydrolase_4
HKD2_k127_5921091_83	938709.AUSH02000016_gene707	1.868e-33	137.0	COG1266@1|root,COG1266@2|Bacteria,4NTIG@976|Bacteroidetes	976|Bacteroidetes	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_5921091_96	627192.SLG_23210	8.126e-12	69.0	COG2906@1|root,COG2906@2|Bacteria,1NI9P@1224|Proteobacteria,2UKEU@28211|Alphaproteobacteria,2KDRJ@204457|Sphingomonadales	204457|Sphingomonadales	P	BFD-like [2Fe-2S] binding domain	-	-	-	ko:K02192	-	-	-	-	ko00000	-	-	-	Fer2_BFD
HKD2_k127_5921091_61	1112212.JH584235_gene464	9.581e-75	254.0	COG2193@1|root,COG2193@2|Bacteria,1RCW7@1224|Proteobacteria,2U70I@28211|Alphaproteobacteria,2K3XA@204457|Sphingomonadales	204457|Sphingomonadales	P	Iron-storage protein, whose ferroxidase center binds Fe(2 ) ions, oxidizes them by dioxygen to Fe(3 ), and participates in the subsequent Fe(3 ) oxide mineral core formation within the central cavity of the protein complex	bfr	-	1.16.3.1	ko:K03594	ko00860,map00860	-	R00078	RC02758	ko00000,ko00001,ko01000	-	-	-	Ferritin
HKD2_k127_5921091_67	1123267.JONN01000001_gene1723	7.305e-65	226.0	COG2198@1|root,COG2198@2|Bacteria,1NMJT@1224|Proteobacteria,2UQPF@28211|Alphaproteobacteria,2K588@204457|Sphingomonadales	204457|Sphingomonadales	T	Hpt domain	-	-	-	ko:K20976	ko02020,ko02025,map02020,map02025	M00820	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Hpt
HKD2_k127_5921091_11	1123267.JONN01000001_gene1722	1.536e-226	708.0	COG1160@1|root,COG1160@2|Bacteria,1MU9S@1224|Proteobacteria,2TT38@28211|Alphaproteobacteria,2K0SQ@204457|Sphingomonadales	204457|Sphingomonadales	S	GTPase that plays an essential role in the late steps of ribosome biogenesis	der	-	-	ko:K03977	-	-	-	-	ko00000,ko03009	-	-	-	KH_dom-like,MMR_HSR1
HKD2_k127_5921091_20	1123267.JONN01000001_gene1721	3.539e-174	556.0	COG1520@1|root,COG1520@2|Bacteria,1MXIJ@1224|Proteobacteria,2TUAD@28211|Alphaproteobacteria,2K0GW@204457|Sphingomonadales	204457|Sphingomonadales	S	Pyrrolo-quinoline quinone	-	-	-	-	-	-	-	-	-	-	-	-	PQQ_2,PQQ_3
HKD2_k127_5921091_70	1114964.L485_15780	1.83e-55	201.0	COG4649@1|root,COG4649@2|Bacteria,1P2GI@1224|Proteobacteria,2UCFZ@28211|Alphaproteobacteria,2K40C@204457|Sphingomonadales	204457|Sphingomonadales	S	Tetratricopeptide repeat-like domain	-	-	-	-	-	-	-	-	-	-	-	-	TPR_21
HKD2_k127_5921091_31	1123267.JONN01000001_gene1719	3.203e-147	470.0	COG0413@1|root,COG0413@2|Bacteria,1MU3B@1224|Proteobacteria,2TQT1@28211|Alphaproteobacteria,2K1CJ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate	panB	-	2.1.2.11	ko:K00606	ko00770,ko01100,ko01110,map00770,map01100,map01110	M00119	R01226	RC00022,RC00200	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_transf
HKD2_k127_5921091_74	1123269.NX02_21010	3.823e-50	182.0	COG1959@1|root,COG1959@2|Bacteria,1RDA4@1224|Proteobacteria,2U9GW@28211|Alphaproteobacteria,2K4I1@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_5921091_54	1219049.SP5_013_00030	2.458e-88	296.0	COG0745@1|root,COG0745@2|Bacteria,1MU67@1224|Proteobacteria,2TRTZ@28211|Alphaproteobacteria,2K1RM@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K02483	-	-	-	-	ko00000,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_5921091_51	1219049.SP5_037_00060	3.779e-95	329.0	COG0642@1|root,COG2205@2|Bacteria,1MW8M@1224|Proteobacteria,2TUSJ@28211|Alphaproteobacteria,2K1K2@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_5921091_101	1123267.JONN01000001_gene771	7.811e-06	56.0	COG3798@1|root,COG3798@2|Bacteria,1N0BJ@1224|Proteobacteria,2UDJF@28211|Alphaproteobacteria,2KE5H@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HKD2_k127_5921091_75	1123267.JONN01000001_gene1736	7.693e-50	185.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,YkuD
HKD2_k127_5921091_3	1123267.JONN01000001_gene1738	1.374e-304	938.0	COG0519@1|root,COG0519@2|Bacteria,1MU2A@1224|Proteobacteria,2TRN0@28211|Alphaproteobacteria,2JZZK@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the synthesis of GMP from XMP	guaA	-	6.3.5.2	ko:K01951	ko00230,ko00983,ko01100,map00230,map00983,map01100	M00050	R01230,R01231,R08244	RC00010,RC00204	ko00000,ko00001,ko00002,ko01000,ko01002	-	-	-	GATase,GMP_synt_C,NAD_synthase
HKD2_k127_5921091_95	1502850.FG91_04124	1.04e-16	91.0	2ADKP@1|root,313BC@2|Bacteria,1PS56@1224|Proteobacteria,2V4C7@28211|Alphaproteobacteria,2K7RA@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_69	1144305.PMI02_01495	2.849e-56	213.0	COG3063@1|root,COG3063@2|Bacteria,1QYDI@1224|Proteobacteria,2TXPG@28211|Alphaproteobacteria,2KEIF@204457|Sphingomonadales	204457|Sphingomonadales	NU	Protein of unknown function (DUF560)	-	-	-	-	-	-	-	-	-	-	-	-	DUF560
HKD2_k127_5921091_66	1123267.JONN01000001_gene1755	1.748e-69	238.0	COG0203@1|root,COG0203@2|Bacteria,1RCWN@1224|Proteobacteria,2U749@28211|Alphaproteobacteria,2K4J0@204457|Sphingomonadales	204457|Sphingomonadales	J	Ribosomal protein L17	rplQ	-	-	ko:K02879	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L17
HKD2_k127_5921091_38	1248760.ANFZ01000008_gene1579	2.184e-132	433.0	COG3239@1|root,COG3239@2|Bacteria,1MVY5@1224|Proteobacteria,2U156@28211|Alphaproteobacteria,2K0CR@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_desaturase
HKD2_k127_5921091_58	682795.AciX8_1494	1.149e-84	289.0	COG0500@1|root,COG2226@2|Bacteria	2|Bacteria	Q	methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25,Methyltransf_31
HKD2_k127_5921091_21	1123267.JONN01000001_gene411	1.039e-169	540.0	COG0454@1|root,COG0456@2|Bacteria,1PMA3@1224|Proteobacteria,2TUU2@28211|Alphaproteobacteria,2K0BS@204457|Sphingomonadales	204457|Sphingomonadales	K	acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_92	67352.JODS01000024_gene3065	1.933e-21	104.0	29SM0@1|root,30DSB@2|Bacteria,2GN13@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD2_k127_5921091_30	1123267.JONN01000001_gene410	1.752e-147	469.0	COG0708@1|root,COG0708@2|Bacteria,1MVII@1224|Proteobacteria,2TR5J@28211|Alphaproteobacteria,2K0HF@204457|Sphingomonadales	204457|Sphingomonadales	L	exodeoxyribonuclease III	xth	-	3.1.11.2	ko:K01142	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exo_endo_phos
HKD2_k127_5921091_64	383381.EH30_01255	1.889e-72	252.0	COG1813@1|root,COG1813@2|Bacteria,1MXA5@1224|Proteobacteria,2TU2N@28211|Alphaproteobacteria,2K8PS@204457|Sphingomonadales	204457|Sphingomonadales	K	Xre family transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_3,HTH_31
HKD2_k127_5921091_78	383381.EH30_14965	3.428e-45	168.0	COG0316@1|root,COG0316@2|Bacteria,1RHCW@1224|Proteobacteria,2UBR8@28211|Alphaproteobacteria,2K54P@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the HesB IscA family	erpA	-	-	-	-	-	-	-	-	-	-	-	Fe-S_biosyn
HKD2_k127_5921091_46	1123267.JONN01000001_gene408	1.582e-114	381.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TQZE@28211|Alphaproteobacteria,2K148@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0739 Membrane proteins related to metalloendopeptidases	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_5921091_25	398580.Dshi_3317	8.718e-163	522.0	COG1932@1|root,COG1932@2|Bacteria,1MUB5@1224|Proteobacteria,2TSHT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	EH	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine	serC	-	2.6.1.52	ko:K00831	ko00260,ko00680,ko00750,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map00750,map01100,map01120,map01130,map01200,map01230	M00020,M00124	R04173,R05085	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_5
HKD2_k127_5921091_6	1123267.JONN01000001_gene406	3.295e-256	799.0	COG0111@1|root,COG0111@2|Bacteria,1MU5Z@1224|Proteobacteria,2TR0F@28211|Alphaproteobacteria,2K0J0@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family	serA	-	1.1.1.399,1.1.1.95	ko:K00058	ko00260,ko00680,ko01100,ko01120,ko01130,ko01200,ko01230,map00260,map00680,map01100,map01120,map01130,map01200,map01230	M00020	R01513	RC00031	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	2-Hacid_dh,2-Hacid_dh_C,ACT
HKD2_k127_5921091_98	1549858.MC45_17960	1.228e-07	61.0	2AF79@1|root,3156A@2|Bacteria,1P9ZW@1224|Proteobacteria,2UWA2@28211|Alphaproteobacteria,2K5Y5@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_9	1219049.SP5_094_00070	5.444e-237	737.0	COG0104@1|root,COG0104@2|Bacteria,1MU5B@1224|Proteobacteria,2TRKY@28211|Alphaproteobacteria,2K0T7@204457|Sphingomonadales	204457|Sphingomonadales	F	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP	purA	-	6.3.4.4	ko:K01939	ko00230,ko00250,ko01100,map00230,map00250,map01100	M00049	R01135	RC00458,RC00459	ko00000,ko00001,ko00002,ko01000	-	-	-	Adenylsucc_synt
HKD2_k127_5921091_90	685035.ADAE01000018_gene807	1.528e-22	99.0	COG1254@1|root,COG1254@2|Bacteria,1PU46@1224|Proteobacteria,2UF7Z@28211|Alphaproteobacteria,2K720@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the acylphosphatase family	acyP	-	3.6.1.7	ko:K01512	ko00620,ko00627,ko01120,map00620,map00627,map01120	-	R00317,R01421,R01515	RC00043	ko00000,ko00001,ko01000	-	-	-	Acylphosphatase
HKD2_k127_5921091_33	1123267.JONN01000001_gene399	9.287e-146	465.0	COG0623@1|root,COG0623@2|Bacteria,1MV05@1224|Proteobacteria,2TSU4@28211|Alphaproteobacteria,2K0BH@204457|Sphingomonadales	204457|Sphingomonadales	I	Enoyl- acyl-carrier-protein reductase NADH	fabI	-	1.3.1.10,1.3.1.9	ko:K00208	ko00061,ko00333,ko00780,ko01100,ko01130,ko01212,map00061,map00333,map00780,map01100,map01130,map01212	M00083,M00572	R01404,R04429,R04430,R04724,R04725,R04955,R04956,R04958,R04959,R04961,R04962,R04966,R04967,R04969,R04970,R07765,R10118,R10122,R11671	RC00052,RC00076,RC00120	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	adh_short_C2
HKD2_k127_5921091_41	1123267.JONN01000001_gene398	8.121e-129	419.0	COG1295@1|root,COG1295@2|Bacteria,1MXQA@1224|Proteobacteria,2TTN5@28211|Alphaproteobacteria,2K0UY@204457|Sphingomonadales	204457|Sphingomonadales	S	ribonuclease BN	-	-	-	ko:K07058	-	-	-	-	ko00000	-	-	-	Virul_fac_BrkB
HKD2_k127_5921091_42	1123267.JONN01000001_gene397	5.195e-125	415.0	COG0484@1|root,COG0484@2|Bacteria,1MUZ4@1224|Proteobacteria,2TR01@28211|Alphaproteobacteria,2K1JP@204457|Sphingomonadales	204457|Sphingomonadales	O	molecular chaperone	dnaJ_2	-	-	-	-	-	-	-	-	-	-	-	DnaJ,DnaJ_C
HKD2_k127_5921091_52	1090320.KB900605_gene1609	2.412e-94	312.0	COG0259@1|root,COG0259@2|Bacteria,1NZUU@1224|Proteobacteria,2TT1U@28211|Alphaproteobacteria,2K0J3@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)	pdxH	-	1.4.3.5	ko:K00275	ko00750,ko01100,ko01120,map00750,map01100,map01120	M00124	R00277,R00278,R01710,R01711	RC00048,RC00116	ko00000,ko00001,ko00002,ko01000	-	-	-	PNP_phzG_C,Putative_PNPOx
HKD2_k127_5921091_45	1123267.JONN01000001_gene395	3.752e-118	388.0	COG0053@1|root,COG0053@2|Bacteria,1MUDS@1224|Proteobacteria,2TT78@28211|Alphaproteobacteria,2K09U@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family	fieF	-	-	ko:K13283	-	-	-	-	ko00000,ko02000	2.A.4.7.1	-	-	Cation_efflux,ZT_dimer
HKD2_k127_5921091_76	450851.PHZ_c2640	8.709e-49	180.0	COG4319@1|root,COG4319@2|Bacteria,1MZRB@1224|Proteobacteria,2UK7M@28211|Alphaproteobacteria,2KHHC@204458|Caulobacterales	204458|Caulobacterales	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_5921091_23	1112216.JH594425_gene1190	5.991e-168	534.0	COG2021@1|root,COG2021@2|Bacteria,1MVJV@1224|Proteobacteria,2TTTV@28211|Alphaproteobacteria,2K296@204457|Sphingomonadales	204457|Sphingomonadales	E	alpha/beta hydrolase fold	-	-	2.3.1.31	ko:K00641	ko00270,ko01100,ko01130,map00270,map01100,map01130	-	R01776	RC00004,RC00041	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_5921091_73	13689.BV96_01501	6.355e-51	191.0	COG4119@1|root,COG4119@2|Bacteria,1RHCE@1224|Proteobacteria,2U8N1@28211|Alphaproteobacteria,2K5NT@204457|Sphingomonadales	204457|Sphingomonadales	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_5921091_19	1123267.JONN01000001_gene392	8.814e-181	572.0	COG0482@1|root,COG0482@2|Bacteria,1MUT1@1224|Proteobacteria,2TQU7@28211|Alphaproteobacteria,2K1HV@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34	mnmA	-	2.8.1.13	ko:K00566	ko04122,map04122	-	R08700	RC02313,RC02315	ko00000,ko00001,ko01000,ko03016	-	-	-	tRNA_Me_trans
HKD2_k127_5921091_77	1174684.EBMC1_00345	1.265e-48	175.0	2AMHV@1|root,31CDG@2|Bacteria,1RGVA@1224|Proteobacteria,2U98Q@28211|Alphaproteobacteria,2K54G@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1153)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1153
HKD2_k127_5921091_84	1114964.L485_07765	5.035e-32	127.0	COG2261@1|root,COG2261@2|Bacteria,1N8B3@1224|Proteobacteria,2UKNY@28211|Alphaproteobacteria,2K64H@204457|Sphingomonadales	204457|Sphingomonadales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_5921091_65	745310.G432_10495	2.503e-70	245.0	COG2968@1|root,COG2968@2|Bacteria,1RH7T@1224|Proteobacteria,2U981@28211|Alphaproteobacteria,2K40S@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09807	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_5921091_87	1121033.AUCF01000046_gene551	1.162e-26	115.0	COG2261@1|root,COG2261@2|Bacteria,1N72W@1224|Proteobacteria,2UBU4@28211|Alphaproteobacteria,2JTUG@204441|Rhodospirillales	204441|Rhodospirillales	S	Transglycosylase associated protein	-	-	-	-	-	-	-	-	-	-	-	-	Transgly_assoc
HKD2_k127_5921091_29	1123267.JONN01000001_gene387	4.365e-148	479.0	COG0845@1|root,COG0845@2|Bacteria,1MXGH@1224|Proteobacteria,2U18A@28211|Alphaproteobacteria,2K0EM@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	-	-	-	-	-	-	-	-	-	HlyD_D23
HKD2_k127_5921091_1	1123267.JONN01000001_gene386	0.0	1300.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K0BI@204457|Sphingomonadales	204457|Sphingomonadales	V	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_5921091_16	1123267.JONN01000001_gene385	1.653e-191	605.0	COG2733@1|root,COG2733@2|Bacteria,1MX3G@1224|Proteobacteria,2U15J@28211|Alphaproteobacteria,2K0FY@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF445
HKD2_k127_5921091_91	1217720.ALOX01000008_gene1796	1.696e-21	106.0	COG0454@1|root,COG0456@2|Bacteria,1N2EC@1224|Proteobacteria	1224|Proteobacteria	K	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases	-	-	2.3.1.57	ko:K22441	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_5921091_12	1123267.JONN01000001_gene377	9.588e-225	701.0	COG0766@1|root,COG0766@2|Bacteria,1MUH7@1224|Proteobacteria,2TRPH@28211|Alphaproteobacteria,2K1H1@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine	murA	-	2.5.1.7	ko:K00790	ko00520,ko00550,ko01100,map00520,map00550,map01100	-	R00660	RC00350	ko00000,ko00001,ko01000,ko01011	-	-	-	EPSP_synthase
HKD2_k127_5921091_68	1123267.JONN01000001_gene378	3.868e-57	200.0	COG2127@1|root,COG2127@2|Bacteria,1MZU8@1224|Proteobacteria,2U982@28211|Alphaproteobacteria,2K5BT@204457|Sphingomonadales	204457|Sphingomonadales	S	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation	clpS	-	-	ko:K06891	-	-	-	-	ko00000	-	-	-	ClpS
HKD2_k127_5921091_81	1123267.JONN01000001_gene379	5.667e-35	147.0	COG5490@1|root,COG5490@2|Bacteria,1N3RI@1224|Proteobacteria,2UDTZ@28211|Alphaproteobacteria,2K476@204457|Sphingomonadales	204457|Sphingomonadales	S	Phasin protein	-	-	-	-	-	-	-	-	-	-	-	-	Phasin_2
HKD2_k127_5921091_56	1123267.JONN01000001_gene380	1.393e-86	292.0	COG0194@1|root,COG0194@2|Bacteria,1MW92@1224|Proteobacteria,2TSCQ@28211|Alphaproteobacteria,2K16A@204457|Sphingomonadales	204457|Sphingomonadales	F	Essential for recycling GMP and indirectly, cGMP	gmk	-	2.7.4.8	ko:K00942	ko00230,ko01100,map00230,map01100	M00050	R00332,R02090	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Guanylate_kin
HKD2_k127_5921091_57	1123267.JONN01000001_gene381	2.094e-85	288.0	COG5387@1|root,COG5387@2|Bacteria,1Q3B5@1224|Proteobacteria,2TVK1@28211|Alphaproteobacteria,2K1FD@204457|Sphingomonadales	204457|Sphingomonadales	O	Chaperone required for the assembly of the mitochondrial F1-ATPase	-	-	-	-	-	-	-	-	-	-	-	-	ATP12
HKD2_k127_5921091_63	1123267.JONN01000001_gene383	2.914e-73	255.0	COG0546@1|root,COG0546@2|Bacteria,1RDA7@1224|Proteobacteria,2U703@28211|Alphaproteobacteria,2K3XQ@204457|Sphingomonadales	204457|Sphingomonadales	S	Hydrolase	-	-	3.1.3.18	ko:K01091	ko00630,ko01100,ko01110,ko01130,map00630,map01100,map01110,map01130	-	R01334	RC00017	ko00000,ko00001,ko01000	-	-	-	HAD_2
HKD2_k127_5921091_28	1030157.AFMP01000044_gene1752	3.712e-156	500.0	COG0564@1|root,COG0564@2|Bacteria,1MVDX@1224|Proteobacteria,2TTQC@28211|Alphaproteobacteria,2K1YR@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for synthesis of pseudouridine from uracil	-	-	5.4.99.24	ko:K06179	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2
HKD2_k127_5921091_80	1380391.JIAS01000012_gene4533	2.315e-36	144.0	2E4C3@1|root,32Z7N@2|Bacteria,1N1SM@1224|Proteobacteria,2UEBN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_60	1123267.JONN01000001_gene375	1.766e-78	269.0	2E21J@1|root,32X9B@2|Bacteria,1NEYU@1224|Proteobacteria,2UJ33@28211|Alphaproteobacteria,2K6I0@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4893)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4893
HKD2_k127_5921091_47	1123267.JONN01000001_gene374	2.113e-106	354.0	COG2962@1|root,COG2962@2|Bacteria,1MX5G@1224|Proteobacteria,2TV8D@28211|Alphaproteobacteria,2K1SV@204457|Sphingomonadales	204457|Sphingomonadales	S	RarD protein	-	-	-	ko:K05786	-	-	-	-	ko00000,ko02000	2.A.7.7	-	-	EamA
HKD2_k127_5921091_72	1300345.LF41_1001	9.356e-52	192.0	COG4430@1|root,COG4430@2|Bacteria,1RG2R@1224|Proteobacteria,1T0AD@1236|Gammaproteobacteria,1X6JK@135614|Xanthomonadales	135614|Xanthomonadales	S	Bacteriocin-protection, YdeI or OmpD-Associated	-	-	-	-	-	-	-	-	-	-	-	-	DUF1801,OmdA
HKD2_k127_5921091_88	1320556.AVBP01000009_gene2469	2.904e-26	113.0	COG0454@1|root,COG0454@2|Bacteria	2|Bacteria	K	-acetyltransferase	yrkN	-	2.3.1.82	ko:K03826,ko:K03827,ko:K18816	-	-	-	-	br01600,ko00000,ko01000,ko01504	-	-	-	Acetyltransf_1,Acetyltransf_10,Acetyltransf_7
HKD2_k127_5921091_4	1123267.JONN01000001_gene372	1.046e-274	855.0	COG3243@1|root,COG3243@2|Bacteria,1MU68@1224|Proteobacteria,2TR7S@28211|Alphaproteobacteria,2K0U9@204457|Sphingomonadales	204457|Sphingomonadales	I	poly(R)-hydroxyalkanoic acid synthase	phaC	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_1,PhaC_N
HKD2_k127_5921091_59	1123267.JONN01000001_gene371	5.744e-79	268.0	COG2860@1|root,COG2860@2|Bacteria,1RHQN@1224|Proteobacteria,2U6B7@28211|Alphaproteobacteria,2KD4Q@204457|Sphingomonadales	204457|Sphingomonadales	S	UPF0126 domain	-	-	-	-	-	-	-	-	-	-	-	-	UPF0126
HKD2_k127_5921091_35	1123267.JONN01000001_gene1962	1.609e-143	465.0	COG1680@1|root,COG1680@2|Bacteria,1RB35@1224|Proteobacteria,2U2A3@28211|Alphaproteobacteria,2K36P@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase
HKD2_k127_5921091_85	1267533.KB906741_gene652	1.543e-31	129.0	COG0346@1|root,COG0346@2|Bacteria	2|Bacteria	E	lactoylglutathione lyase activity	ysfE	-	2.7.1.49,2.7.4.7,4.2.1.96,4.4.1.5	ko:K00941,ko:K01724,ko:K01759,ko:K07032,ko:K08234	ko00620,ko00730,ko00790,ko01100,map00620,map00730,map00790,map01100	M00127	R02530,R03471,R04509,R04734	RC00002,RC00004,RC00017,RC00740,RC01208	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Glyoxalase
HKD2_k127_5921091_13	1123267.JONN01000001_gene1881	2.042e-218	687.0	COG0626@1|root,COG0626@2|Bacteria,1MU57@1224|Proteobacteria,2TW14@28211|Alphaproteobacteria,2K1W3@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the formation of methanethiol and 2-ocobutanoate from L-methionine	-	-	4.4.1.11	ko:K01761	ko00270,ko00450,map00270,map00450	-	R00654,R04770	RC00196,RC00348,RC01209,RC01210	ko00000,ko00001,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_5921091_48	1090320.KB900605_gene1242	4.763e-104	345.0	COG1496@1|root,COG1496@2|Bacteria,1MW2H@1224|Proteobacteria,2TTXU@28211|Alphaproteobacteria,2K13X@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the multicopper oxidase YfiH RL5 family	-	-	-	ko:K05810	-	-	-	-	ko00000,ko01000	-	-	-	Cu-oxidase_4
HKD2_k127_5921091_71	1550073.JROH01000006_gene1499	8.542e-52	190.0	COG0454@1|root,COG0456@2|Bacteria,1MZA6@1224|Proteobacteria,2UCC0@28211|Alphaproteobacteria,2K4CY@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1,Acetyltransf_10
HKD2_k127_5921091_43	1123267.JONN01000001_gene1942	1.253e-121	398.0	COG1565@1|root,COG1565@2|Bacteria,1N3CJ@1224|Proteobacteria,2TRHW@28211|Alphaproteobacteria,2K21E@204457|Sphingomonadales	204457|Sphingomonadales	M	Putative S-adenosyl-L-methionine-dependent methyltransferase	-	-	-	ko:K18164	ko04714,map04714	-	-	-	ko00000,ko00001,ko03029	-	-	-	Methyltransf_28
HKD2_k127_5921091_37	1123267.JONN01000001_gene1941	1.462e-139	448.0	COG0682@1|root,COG0682@2|Bacteria,1MVE3@1224|Proteobacteria,2TTNS@28211|Alphaproteobacteria,2K1JZ@204457|Sphingomonadales	204457|Sphingomonadales	M	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins	lgt	-	-	ko:K13292	-	-	-	-	ko00000,ko01000	-	-	-	LGT
HKD2_k127_5921091_7	1123267.JONN01000001_gene1940	2.481e-251	785.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TR2W@28211|Alphaproteobacteria,2JZZB@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	-	-	-	-	-	-	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_5921091_27	1123267.JONN01000001_gene1939	3.463e-157	524.0	COG1529@1|root,COG1529@2|Bacteria,1QTTJ@1224|Proteobacteria,2TQVK@28211|Alphaproteobacteria,2K25R@204457|Sphingomonadales	204457|Sphingomonadales	C	aerobic-type carbon monoxide dehydrogenase, large subunit CoxL	-	-	1.3.99.16	ko:K07303	-	-	-	-	ko00000,ko01000	-	-	-	Ald_Xan_dh_C,Ald_Xan_dh_C2
HKD2_k127_5921091_34	1123267.JONN01000001_gene1938	2.614e-145	467.0	COG0276@1|root,COG0276@2|Bacteria,1MVR1@1224|Proteobacteria,2TSMS@28211|Alphaproteobacteria,2K0NQ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ferrous insertion into protoporphyrin IX	hemH	-	4.99.1.1,4.99.1.9	ko:K01772	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R00310,R11329	RC01012	ko00000,ko00001,ko00002,ko01000	-	-	-	Ferrochelatase
HKD2_k127_5921091_39	1123267.JONN01000001_gene1937	9.785e-132	422.0	COG1028@1|root,COG1028@2|Bacteria,1MUEV@1224|Proteobacteria,2TRCF@28211|Alphaproteobacteria,2K0A2@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Acetoacetyl-CoA reductase	phbB	-	1.1.1.36	ko:K00023	ko00630,ko00650,ko01120,ko01200,map00630,map00650,map01120,map01200	M00373	R01779,R01977	RC00103,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	adh_short_C2
HKD2_k127_5921091_89	1120705.FG95_00495	5.144e-24	104.0	COG4321@1|root,COG4321@2|Bacteria,1PSCA@1224|Proteobacteria,2VA8Q@28211|Alphaproteobacteria,2K6W1@204457|Sphingomonadales	204457|Sphingomonadales	S	protein related to arylsulfate sulfotransferase involved in siderophore biosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	RHH_4
HKD2_k127_5921091_53	1123267.JONN01000001_gene1935	3.349e-92	312.0	COG0189@1|root,COG0189@2|Bacteria,1MV29@1224|Proteobacteria,2U88X@28211|Alphaproteobacteria,2K3W3@204457|Sphingomonadales	204457|Sphingomonadales	HJ	COG0189 Glutathione synthase Ribosomal protein S6 modification enzyme (glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	GSH-S_ATP
HKD2_k127_5921091_0	685778.AORL01000009_gene3208	0.0	1771.0	COG2902@1|root,COG2902@2|Bacteria,1MXNV@1224|Proteobacteria,2TS89@28211|Alphaproteobacteria,2K0WP@204457|Sphingomonadales	204457|Sphingomonadales	E	glutamate dehydrogenase	-	-	1.4.1.2	ko:K15371	ko00220,ko00250,ko00430,ko00910,ko01100,map00220,map00250,map00430,map00910,map01100	-	R00243	RC00006,RC02799	ko00000,ko00001,ko01000	-	-	-	Bac_GDH
HKD2_k127_5921091_40	1123267.JONN01000001_gene1933	1.732e-131	436.0	COG5388@1|root,COG5388@2|Bacteria,1R74W@1224|Proteobacteria,2TUTW@28211|Alphaproteobacteria,2K1EC@204457|Sphingomonadales	204457|Sphingomonadales	S	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_5921091_97	391595.RLO149_c017560	1.097e-07	53.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria,2P2YR@2433|Roseobacter	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	ko:K07482	-	-	-	-	ko00000	-	-	-	HTH_38,rve
HKD2_k127_5921091_55	1500301.JQMF01000008_gene982	4.946e-88	307.0	COG3637@1|root,COG3637@2|Bacteria,1R3Z1@1224|Proteobacteria,2U1SQ@28211|Alphaproteobacteria,4BAX2@82115|Rhizobiaceae	28211|Alphaproteobacteria	M	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_5921091_5	1500257.JQNM01000011_gene5592	8.191e-272	852.0	28HMZ@1|root,2Z7WD@2|Bacteria,1MU3Q@1224|Proteobacteria,2TSGX@28211|Alphaproteobacteria,4BCDP@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3604)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3604
HKD2_k127_604892_70	1123267.JONN01000001_gene1145	1.566e-54	194.0	2E4J2@1|root,32ZE4@2|Bacteria,1RHJR@1224|Proteobacteria,2V5X3@28211|Alphaproteobacteria,2K5FN@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF3775)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3775
HKD2_k127_604892_69	1123267.JONN01000001_gene1144	8.125e-56	203.0	COG1514@1|root,COG1514@2|Bacteria,1RIHA@1224|Proteobacteria,2UAUZ@28211|Alphaproteobacteria,2K46A@204457|Sphingomonadales	204457|Sphingomonadales	J	2'-5' RNA ligase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	2_5_RNA_ligase2
HKD2_k127_604892_73	1123267.JONN01000001_gene1143	3.532e-53	196.0	COG1873@1|root,COG1873@2|Bacteria	2|Bacteria	S	PRC-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	PRC
HKD2_k127_604892_5	1123267.JONN01000001_gene1142	1.372e-296	922.0	COG3158@1|root,COG3158@2|Bacteria,1MUVH@1224|Proteobacteria,2TRVJ@28211|Alphaproteobacteria,2JZUZ@204457|Sphingomonadales	204457|Sphingomonadales	P	Transport of potassium into the cell	kup	-	-	ko:K03549	-	-	-	-	ko00000,ko02000	2.A.72	-	-	K_trans
HKD2_k127_604892_21	1123267.JONN01000001_gene1141	5.531e-201	629.0	COG0686@1|root,COG0686@2|Bacteria,1QTX1@1224|Proteobacteria,2TQQC@28211|Alphaproteobacteria,2K0C2@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the AlaDH PNT family	ald	-	1.4.1.1	ko:K00259	ko00250,ko00430,ko01100,map00250,map00430,map01100	-	R00396	RC00008	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_604892_57	509190.Cseg_3573	8.201e-83	292.0	COG0793@1|root,COG0793@2|Bacteria,1R0PD@1224|Proteobacteria,2TYSP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Peptidase family S41	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41
HKD2_k127_604892_85	1123269.NX02_13240	1.247e-38	156.0	COG4235@1|root,COG4235@2|Bacteria,1RB0I@1224|Proteobacteria,2U69S@28211|Alphaproteobacteria,2K4DU@204457|Sphingomonadales	204457|Sphingomonadales	O	Cytochrome c biogenesis factor	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	TPR_14,TPR_16,TPR_19
HKD2_k127_604892_80	745310.G432_00830	1.39e-46	172.0	COG3088@1|root,COG3088@2|Bacteria,1MZZ5@1224|Proteobacteria,2U96P@28211|Alphaproteobacteria,2K57D@204457|Sphingomonadales	204457|Sphingomonadales	O	subunit of a heme lyase	-	-	-	ko:K02200	-	-	-	-	ko00000	-	-	-	CcmH
HKD2_k127_604892_71	392499.Swit_3991	3.617e-54	195.0	COG0526@1|root,COG0526@2|Bacteria,1RI3N@1224|Proteobacteria,2TSEW@28211|Alphaproteobacteria,2K4IY@204457|Sphingomonadales	204457|Sphingomonadales	CO	Alkyl hydroperoxide reductase	ccmG	-	-	ko:K02199	-	-	-	-	ko00000,ko03110	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_604892_8	1030157.AFMP01000042_gene1293	1.165e-260	817.0	COG1138@1|root,COG1138@2|Bacteria,1MUQS@1224|Proteobacteria,2TRNG@28211|Alphaproteobacteria,2K1MA@204457|Sphingomonadales	204457|Sphingomonadales	O	cytochrome C	ccmF	-	-	ko:K02198	-	-	-	-	ko00000,ko02000	9.B.14.1	-	-	CcmF_C,Cytochrom_C_asm
HKD2_k127_604892_75	1123267.JONN01000001_gene1135	8.6e-51	186.0	COG2332@1|root,COG2332@2|Bacteria,1RHN5@1224|Proteobacteria,2U99J@28211|Alphaproteobacteria,2K56Y@204457|Sphingomonadales	204457|Sphingomonadales	O	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH	ccmE	-	-	ko:K02197	-	-	-	-	ko00000	-	-	-	CcmE
HKD2_k127_604892_48	1123267.JONN01000001_gene1133	2.85e-115	376.0	COG0755@1|root,COG0755@2|Bacteria,1MU61@1224|Proteobacteria,2TSW8@28211|Alphaproteobacteria,2K13J@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes	ccmC	-	-	ko:K02195	ko02010,map02010	M00259	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.107	-	-	Cytochrom_C_asm
HKD2_k127_604892_29	1123267.JONN01000001_gene1132	1.663e-160	511.0	COG0334@1|root,COG0334@2|Bacteria,1MUXS@1224|Proteobacteria,2VGKD@28211|Alphaproteobacteria,2K0AY@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the Glu Leu Phe Val dehydrogenases family	-	-	1.4.1.9	ko:K00263	ko00280,ko00290,ko01100,ko01110,ko01130,map00280,map00290,map01100,map01110,map01130	-	R01088,R01434,R02196	RC00006,RC00036	ko00000,ko00001,ko01000	-	-	-	ELFV_dehydrog,ELFV_dehydrog_N
HKD2_k127_604892_81	702113.PP1Y_AT1142	5.397e-46	170.0	COG0537@1|root,COG0537@2|Bacteria,1N49J@1224|Proteobacteria,2U85A@28211|Alphaproteobacteria,2K4UB@204457|Sphingomonadales	204457|Sphingomonadales	FG	Histidine triad (HIT) protein	-	-	-	-	-	-	-	-	-	-	-	-	HIT
HKD2_k127_604892_53	1123267.JONN01000001_gene1130	1.709e-91	307.0	COG0664@1|root,COG0664@2|Bacteria	2|Bacteria	T	cyclic nucleotide binding	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_604892_90	1081640.AGFU01000005_gene1089	6.974e-35	136.0	COG0776@1|root,COG0776@2|Bacteria,1MZ5B@1224|Proteobacteria,2UC5G@28211|Alphaproteobacteria,2K5WD@204457|Sphingomonadales	204457|Sphingomonadales	L	Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions	-	-	-	ko:K03530	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_604892_0	1123267.JONN01000001_gene1128	0.0	1337.0	COG0466@1|root,COG0466@2|Bacteria,1MUV2@1224|Proteobacteria,2TR4E@28211|Alphaproteobacteria,2K15B@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner	lon	-	3.4.21.53	ko:K01338	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	AAA,LON_substr_bdg,Lon_C
HKD2_k127_604892_51	1346791.M529_10865	1.004e-102	350.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K19X@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_604892_92	1123267.JONN01000001_gene1126	2.969e-32	136.0	2CHH8@1|root,2ZF3B@2|Bacteria,1P6GI@1224|Proteobacteria,2UY3S@28211|Alphaproteobacteria,2K4M3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_604892_11	1123267.JONN01000002_gene308	8.234e-249	771.0	COG1219@1|root,COG1219@2|Bacteria,1MVQK@1224|Proteobacteria,2TS3R@28211|Alphaproteobacteria,2JZWY@204457|Sphingomonadales	204457|Sphingomonadales	O	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP	clpX	-	-	ko:K03544	ko04112,map04112	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA_2,ClpB_D2-small,zf-C4_ClpX
HKD2_k127_604892_64	420324.KI911956_gene3445	3.716e-66	234.0	COG1073@1|root,COG1073@2|Bacteria,1RIWI@1224|Proteobacteria	1224|Proteobacteria	S	COG1073 hydrolases of the alpha beta superfamily	-	-	-	ko:K06889	-	-	-	-	ko00000	-	-	-	Abhydrolase_1,Hydrolase_4
HKD2_k127_604892_83	1123267.JONN01000001_gene881	3.401e-42	157.0	COG0784@1|root,COG0784@2|Bacteria,1N70P@1224|Proteobacteria,2UF5P@28211|Alphaproteobacteria,2K639@204457|Sphingomonadales	204457|Sphingomonadales	T	cheY-homologous receiver domain	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_604892_7	1030157.AFMP01000031_gene2952	1.344e-267	845.0	COG2204@1|root,COG4191@1|root,COG2204@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,2K0WG@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	2.7.13.3	ko:K13587	ko02020,ko04112,map02020,map04112	M00512	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HATPase_c,HisKA,PAS_4,PAS_8,Response_reg
HKD2_k127_604892_2	1449076.JOOE01000001_gene1987	7.969e-305	948.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2K02W@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidase M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD2_k127_604892_89	1112212.JH584235_gene892	5.295e-35	142.0	COG3216@1|root,COG3216@2|Bacteria,1RGV6@1224|Proteobacteria,2UB7Z@28211|Alphaproteobacteria,2K4SW@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09928	-	-	-	-	ko00000	-	-	-	DUF2062
HKD2_k127_604892_60	13689.BV96_01006	4.161e-73	248.0	COG0691@1|root,COG0691@2|Bacteria,1RDFP@1224|Proteobacteria,2U71I@28211|Alphaproteobacteria,2K3YM@204457|Sphingomonadales	204457|Sphingomonadales	O	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene	smpB	-	-	ko:K03664	-	-	-	-	ko00000	-	-	-	SmpB
HKD2_k127_604892_39	1123267.JONN01000001_gene954	6.674e-125	407.0	COG0329@1|root,COG0329@2|Bacteria,1MUCM@1224|Proteobacteria,2TR5W@28211|Alphaproteobacteria,2K09B@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)	dapA	-	4.3.3.7	ko:K01714	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R10147	RC03062,RC03063	ko00000,ko00001,ko00002,ko01000	-	-	-	DHDPS
HKD2_k127_604892_17	1123267.JONN01000001_gene953	1.876e-212	679.0	COG0741@1|root,COG0741@2|Bacteria,1MV3F@1224|Proteobacteria,2TRDB@28211|Alphaproteobacteria,2K0PK@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0741 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM invasin domains)	-	-	-	ko:K08309	-	-	-	-	ko00000,ko01000,ko01011	-	GH23	-	SLT
HKD2_k127_604892_63	1123267.JONN01000001_gene952	6.907e-72	247.0	COG0782@1|root,COG0782@2|Bacteria,1RAP0@1224|Proteobacteria,2U75V@28211|Alphaproteobacteria,2K3X2@204457|Sphingomonadales	204457|Sphingomonadales	K	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreB releases sequences of up to 9 nucleotides in length	greB	-	-	ko:K04760	-	-	-	-	ko00000,ko03021	-	-	-	GreA_GreB,GreA_GreB_N
HKD2_k127_604892_76	745310.G432_18010	5.453e-49	183.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2K0KF@204457|Sphingomonadales	204457|Sphingomonadales	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	-	-	-	-	-	-	-	-	-	-	PPK2
HKD2_k127_604892_1	317655.Sala_1751	0.0	999.0	COG0173@1|root,COG0173@2|Bacteria,1MUXB@1224|Proteobacteria,2TR9U@28211|Alphaproteobacteria,2K0PT@204457|Sphingomonadales	204457|Sphingomonadales	J	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)	aspS	-	6.1.1.12	ko:K01876	ko00970,map00970	M00359,M00360	R05577	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016,ko03029	-	-	-	GAD,tRNA-synt_2,tRNA_anti-codon
HKD2_k127_604892_18	1123267.JONN01000001_gene947	4.034e-209	655.0	COG0349@1|root,COG0349@2|Bacteria,1MURV@1224|Proteobacteria,2TSQM@28211|Alphaproteobacteria,2K0ID@204457|Sphingomonadales	204457|Sphingomonadales	J	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides	rnd	-	3.1.13.5	ko:K03684	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	DNA_pol_A_exo1,HRDC
HKD2_k127_604892_56	1123267.JONN01000001_gene943	2.008e-83	290.0	COG0593@1|root,COG0593@2|Bacteria,1N4PG@1224|Proteobacteria,2U96K@28211|Alphaproteobacteria,2K4AT@204457|Sphingomonadales	204457|Sphingomonadales	L	ATPase involved in DNA replication	-	-	-	-	-	-	-	-	-	-	-	-	Bac_DnaA
HKD2_k127_604892_46	1123267.JONN01000001_gene942	2.24e-116	389.0	COG3249@1|root,COG3249@2|Bacteria,1R81G@1224|Proteobacteria,2U1EP@28211|Alphaproteobacteria,2K0TT@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_604892_28	1007104.SUS17_292	1.56e-161	516.0	COG0150@1|root,COG0150@2|Bacteria,1MURG@1224|Proteobacteria,2TR6G@28211|Alphaproteobacteria,2K07H@204457|Sphingomonadales	204457|Sphingomonadales	F	Phosphoribosylformylglycinamidine cyclo-ligase	purM	-	6.3.3.1	ko:K01933	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04208	RC01100	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_604892_62	1112212.JH584235_gene534	2.359e-72	250.0	COG0299@1|root,COG0299@2|Bacteria,1MWN1@1224|Proteobacteria,2TRY6@28211|Alphaproteobacteria,2K28Q@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	purN	-	2.1.2.2	ko:K11175	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	Formyl_trans_N,YjbR
HKD2_k127_604892_82	1449076.JOOE01000001_gene1820	1.52e-44	164.0	COG3801@1|root,COG3801@2|Bacteria,1PTCF@1224|Proteobacteria,2V58I@28211|Alphaproteobacteria,2K60B@204457|Sphingomonadales	204457|Sphingomonadales	S	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD2_k127_604892_25	1174684.EBMC1_13366	6.921e-187	596.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2TUW3@28211|Alphaproteobacteria,2K25Z@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2,PLDc_N
HKD2_k127_604892_61	702113.PP1Y_AT20481	5.915e-73	248.0	COG0105@1|root,COG0105@2|Bacteria,1R9ZA@1224|Proteobacteria,2U5CS@28211|Alphaproteobacteria,2K3WY@204457|Sphingomonadales	204457|Sphingomonadales	F	Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate	ndk	-	2.7.4.6	ko:K00940	ko00230,ko00240,ko00983,ko01100,ko01110,ko01130,ko04016,map00230,map00240,map00983,map01100,map01110,map01130,map04016	M00049,M00050,M00052,M00053	R00124,R00139,R00156,R00330,R00570,R00722,R01137,R01857,R02093,R02326,R02331,R03530,R11894,R11895	RC00002	ko00000,ko00001,ko00002,ko01000,ko04131	-	-	-	NDK
HKD2_k127_604892_67	1123267.JONN01000001_gene933	3.573e-58	205.0	COG2927@1|root,COG2927@2|Bacteria,1RGVC@1224|Proteobacteria,2U94V@28211|Alphaproteobacteria,2K5Y0@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase III	holC	-	2.7.7.7	ko:K02339	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_chi
HKD2_k127_604892_19	1123267.JONN01000001_gene932	1.146e-202	641.0	COG0260@1|root,COG0260@2|Bacteria,1MUF9@1224|Proteobacteria,2TQU9@28211|Alphaproteobacteria,2K04B@204457|Sphingomonadales	204457|Sphingomonadales	E	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides	pepA	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17,Peptidase_M17_N
HKD2_k127_604892_6	1123267.JONN01000001_gene931	2.154e-286	897.0	COG1452@1|root,COG1452@2|Bacteria,1MUJC@1224|Proteobacteria,2TR3B@28211|Alphaproteobacteria,2K1GQ@204457|Sphingomonadales	204457|Sphingomonadales	M	Involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane	lptD	-	-	ko:K04744	-	-	-	-	ko00000,ko02000	1.B.42.1	-	-	OstA,OstA_C
HKD2_k127_604892_26	1123267.JONN01000001_gene930	3.384e-180	576.0	COG0760@1|root,COG0760@2|Bacteria,1MVB3@1224|Proteobacteria,2TSJ3@28211|Alphaproteobacteria,2K0UR@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidylprolyl isomerase	surA	-	5.2.1.8	ko:K03771	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,SurA_N,SurA_N_3
HKD2_k127_604892_31	1123267.JONN01000001_gene929	8.971e-150	485.0	COG1995@1|root,COG1995@2|Bacteria,1MX5W@1224|Proteobacteria,2TSKF@28211|Alphaproteobacteria,2K0HZ@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)	pdxA	-	1.1.1.262	ko:K00097	ko00750,ko01100,map00750,map01100	M00124	R05681,R05837,R07406	RC00089,RC00675,RC01475	ko00000,ko00001,ko00002,ko01000	-	-	-	PdxA
HKD2_k127_604892_41	1123267.JONN01000001_gene928	2.151e-120	394.0	COG0030@1|root,COG0030@2|Bacteria,1MVNU@1224|Proteobacteria,2TRD9@28211|Alphaproteobacteria,2K042@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits	ksgA	-	2.1.1.182	ko:K02528	-	-	R10716	RC00003,RC03257	ko00000,ko01000,ko03009	-	-	-	RrnaAD
HKD2_k127_604892_87	1123267.JONN01000001_gene927	3.524e-37	147.0	COG3063@1|root,COG3063@2|Bacteria,1R17W@1224|Proteobacteria,2TYY0@28211|Alphaproteobacteria,2KEPF@204457|Sphingomonadales	204457|Sphingomonadales	NU	Type IV pilus biogenesis stability protein PilW	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_8
HKD2_k127_604892_33	1123267.JONN01000001_gene926	2.607e-147	475.0	COG0144@1|root,COG0144@2|Bacteria,1MV2Q@1224|Proteobacteria,2TS6U@28211|Alphaproteobacteria,2K17G@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB NOP family	-	-	2.1.1.176	ko:K03500	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Methyltr_RsmB-F
HKD2_k127_604892_10	1123267.JONN01000001_gene925	5.593e-254	791.0	COG0516@1|root,COG0517@1|root,COG0516@2|Bacteria,COG0517@2|Bacteria,1MUJM@1224|Proteobacteria,2TQXC@28211|Alphaproteobacteria,2K0CG@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth	guaB	-	1.1.1.205	ko:K00088	ko00230,ko00983,ko01100,ko01110,map00230,map00983,map01100,map01110	M00050	R01130,R08240	RC00143,RC02207	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	CBS,IMPDH,NMO
HKD2_k127_604892_58	1123267.JONN01000001_gene924	2.406e-81	279.0	COG2301@1|root,COG2301@2|Bacteria,1MW0A@1224|Proteobacteria,2TTC0@28211|Alphaproteobacteria,2K2U8@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the HpcH HpaI aldolase family	-	-	4.1.3.34	ko:K01644	ko02020,map02020	-	R00362	RC00067,RC01118	ko00000,ko00001,ko01000	-	-	-	HpcH_HpaI
HKD2_k127_604892_36	1123267.JONN01000001_gene923	4.599e-145	469.0	COG0330@1|root,COG0330@2|Bacteria,1MUM8@1224|Proteobacteria,2TRUY@28211|Alphaproteobacteria,2K2F3@204457|Sphingomonadales	204457|Sphingomonadales	O	COG0330 Membrane protease subunits, stomatin prohibitin homologs	qmcA	-	-	-	-	-	-	-	-	-	-	-	Band_7,Band_7_C
HKD2_k127_604892_88	1123267.JONN01000001_gene922	4.34e-36	147.0	COG1585@1|root,COG1585@2|Bacteria,1N241@1224|Proteobacteria,2UC8X@28211|Alphaproteobacteria,2K5WQ@204457|Sphingomonadales	204457|Sphingomonadales	OU	Membrane protein implicated in regulation of membrane protease activity	-	-	-	ko:K07340	-	-	-	-	ko00000	-	-	-	NfeD
HKD2_k127_604892_9	1502850.FG91_01416	5.268e-255	806.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0TH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_604892_35	999541.bgla_1g30870	2.464e-145	475.0	COG0477@1|root,COG0477@2|Bacteria,1MWUR@1224|Proteobacteria,2VMD4@28216|Betaproteobacteria,1K2DY@119060|Burkholderiaceae	28216|Betaproteobacteria	EGP	PFAM major facilitator superfamily MFS_1	-	-	-	ko:K08169	-	-	-	-	ko00000,ko02000	2.A.1.3.17	-	-	MFS_1
HKD2_k127_604892_84	13690.CP98_00125	7.145e-41	159.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD2_k127_604892_14	1247963.JPHU01000001_gene1893	3.714e-235	741.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSQN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_604892_68	1449076.JOOE01000001_gene1961	1.809e-57	208.0	2CKCH@1|root,331PP@2|Bacteria,1QYXW@1224|Proteobacteria,2TY15@28211|Alphaproteobacteria,2KEKB@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_604892_4	1123267.JONN01000001_gene919	3.504e-298	920.0	COG1866@1|root,COG1866@2|Bacteria,1MWXN@1224|Proteobacteria,2TRC4@28211|Alphaproteobacteria,2JZZG@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA	pckA	-	4.1.1.49	ko:K01610	ko00010,ko00020,ko00620,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00170	R00341	RC00002,RC02741	ko00000,ko00001,ko00002,ko01000	-	-	-	PEPCK_ATP
HKD2_k127_604892_49	1550073.JROH01000004_gene2158	6.192e-111	364.0	COG0745@1|root,COG0745@2|Bacteria,1MVCB@1224|Proteobacteria,2TR43@28211|Alphaproteobacteria,2JZVH@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	-	-	-	ko:K14981	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_604892_23	1123267.JONN01000001_gene917	1.124e-194	622.0	COG0642@1|root,COG2205@2|Bacteria,1N17V@1224|Proteobacteria,2TS69@28211|Alphaproteobacteria,2K1JA@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	2.7.13.3	ko:K14980	ko02020,map02020	M00520	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,Sensor_TM1,Stimulus_sens_1
HKD2_k127_604892_72	1123267.JONN01000001_gene916	8.253e-54	194.0	COG1493@1|root,COG1493@2|Bacteria,1NNN5@1224|Proteobacteria,2UFPB@28211|Alphaproteobacteria,2K65M@204457|Sphingomonadales	204457|Sphingomonadales	T	Serine kinase of the HPr protein, regulates carbohydrate metabolism	-	-	-	-	-	-	-	-	-	-	-	-	Hpr_kinase_C
HKD2_k127_604892_45	1123267.JONN01000001_gene915	1.808e-117	386.0	COG1660@1|root,COG1660@2|Bacteria,1MVX6@1224|Proteobacteria,2TTI4@28211|Alphaproteobacteria,2K01M@204457|Sphingomonadales	204457|Sphingomonadales	T	Displays ATPase and GTPase activities	-	-	-	ko:K06958	-	-	-	-	ko00000,ko03019	-	-	-	ATP_bind_2
HKD2_k127_604892_65	1030157.AFMP01000019_gene613	4.014e-63	220.0	COG2893@1|root,COG2893@2|Bacteria,1RHH7@1224|Proteobacteria,2U9E5@28211|Alphaproteobacteria,2K4MZ@204457|Sphingomonadales	204457|Sphingomonadales	G	PTS fructose transporter subunit IIA	-	-	2.7.1.191	ko:K02793	ko00051,ko00520,ko01100,ko02060,map00051,map00520,map01100,map02060	M00276	R02630	RC00017,RC03206	ko00000,ko00001,ko00002,ko01000,ko02000	4.A.6.1	-	-	EIIA-man
HKD2_k127_604892_94	1123267.JONN01000001_gene913	4.233e-30	123.0	COG1925@1|root,COG1925@2|Bacteria,1N6RM@1224|Proteobacteria,2UC0H@28211|Alphaproteobacteria,2K638@204457|Sphingomonadales	204457|Sphingomonadales	G	COG1925 Phosphotransferase system, HPr-related proteins	ptsH	-	-	ko:K11189	-	-	-	-	ko00000,ko02000	4.A.2.1	-	-	PTS-HPr
HKD2_k127_604892_42	745310.G432_02965	2.565e-119	388.0	COG0566@1|root,COG0566@2|Bacteria,1MWBE@1224|Proteobacteria,2TT4Y@28211|Alphaproteobacteria,2K16F@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family	-	-	-	ko:K03437	-	-	-	-	ko00000,ko03016	-	-	-	SpoU_methylase,SpoU_sub_bind
HKD2_k127_604892_91	1123267.JONN01000001_gene910	2.777e-34	136.0	COG3187@1|root,COG3650@1|root,COG3187@2|Bacteria,COG3650@2|Bacteria,1MXIV@1224|Proteobacteria,2U2HT@28211|Alphaproteobacteria,2K6CZ@204457|Sphingomonadales	204457|Sphingomonadales	O	META domain	-	-	-	-	-	-	-	-	-	-	-	-	META
HKD2_k127_604892_32	1123267.JONN01000001_gene909	3.345e-148	481.0	COG1322@1|root,COG1322@2|Bacteria,1MWHV@1224|Proteobacteria,2TTX6@28211|Alphaproteobacteria,2K0B3@204457|Sphingomonadales	204457|Sphingomonadales	S	DNA recombination protein	rmuC	-	-	ko:K09760	-	-	-	-	ko00000	-	-	-	RmuC
HKD2_k127_604892_74	1096930.L284_20960	2.68e-52	188.0	COG1145@1|root,32SB1@2|Bacteria,1N096@1224|Proteobacteria,2U9JE@28211|Alphaproteobacteria,2K59E@204457|Sphingomonadales	204457|Sphingomonadales	C	Ferredoxin	-	-	-	-	-	-	-	-	-	-	-	-	DUF326
HKD2_k127_604892_77	1174684.EBMC1_13873	3.032e-48	176.0	COG3805@1|root,COG3805@2|Bacteria	2|Bacteria	Q	Dopa 4,5-dioxygenase family	-	-	-	ko:K10253	-	-	-	-	ko00000,ko01000	-	-	-	DOPA_dioxygen
HKD2_k127_604892_59	1123267.JONN01000002_gene149	1.124e-78	266.0	COG0242@1|root,COG0242@2|Bacteria,1RA2P@1224|Proteobacteria,2U797@28211|Alphaproteobacteria,2K3Y2@204457|Sphingomonadales	204457|Sphingomonadales	J	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions	def	-	3.5.1.88	ko:K01462	-	-	-	-	ko00000,ko01000	-	-	-	Pep_deformylase
HKD2_k127_604892_50	1123267.JONN01000001_gene964	7.746e-106	346.0	COG0353@1|root,COG0353@2|Bacteria,1MV9Q@1224|Proteobacteria,2TRZM@28211|Alphaproteobacteria,2K15N@204457|Sphingomonadales	204457|Sphingomonadales	L	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO	recR	-	-	ko:K06187	ko03440,map03440	-	-	-	ko00000,ko00001,ko03400	-	-	-	RecR,Toprim_4
HKD2_k127_604892_44	1123267.JONN01000001_gene963	6.416e-119	389.0	COG0223@1|root,COG0223@2|Bacteria,1MU4Q@1224|Proteobacteria,2TSWX@28211|Alphaproteobacteria,2K0ZM@204457|Sphingomonadales	204457|Sphingomonadales	J	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus	fmt	-	2.1.2.9	ko:K00604	ko00670,ko00970,map00670,map00970	-	R03940	RC00026,RC00165	ko00000,ko00001,ko01000	-	-	-	Formyl_trans_C,Formyl_trans_N
HKD2_k127_604892_47	1123267.JONN01000001_gene962	2.215e-115	378.0	COG0101@1|root,COG0101@2|Bacteria,1MUYI@1224|Proteobacteria,2TR57@28211|Alphaproteobacteria,2K0ZD@204457|Sphingomonadales	204457|Sphingomonadales	J	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs	truA	-	5.4.99.12	ko:K06173	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	PseudoU_synth_1
HKD2_k127_604892_37	1123269.NX02_13295	7.306e-133	435.0	COG0019@1|root,COG0019@2|Bacteria,1MUA6@1224|Proteobacteria,2TUK2@28211|Alphaproteobacteria,2K0RW@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the Orn Lys Arg decarboxylase class-II family	-	-	4.1.1.20	ko:K01586	ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R00451	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	Orn_Arg_deC_N,Orn_DAP_Arg_deC
HKD2_k127_604892_27	1123267.JONN01000001_gene1276	3.223e-170	538.0	COG0492@1|root,COG0492@2|Bacteria,1MV15@1224|Proteobacteria,2TRBW@28211|Alphaproteobacteria,2K0I2@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family	trxB	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_604892_100	1088721.NSU_3708	3.338e-06	58.0	2EFZF@1|root,339RM@2|Bacteria,1Q79X@1224|Proteobacteria,2UWHC@28211|Alphaproteobacteria,2K7QX@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_604892_3	1123267.JONN01000001_gene1282	4.461e-300	925.0	COG0504@1|root,COG0504@2|Bacteria,1MUIT@1224|Proteobacteria,2TS4Y@28211|Alphaproteobacteria,2K005@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates	pyrG	-	6.3.4.2	ko:K01937	ko00240,ko01100,map00240,map01100	M00052	R00571,R00573	RC00010,RC00074	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_synth_N,GATase
HKD2_k127_604892_96	46429.BV95_01673	9.205e-28	117.0	COG1314@1|root,COG1314@2|Bacteria,1N8MF@1224|Proteobacteria,2UCIP@28211|Alphaproteobacteria,2K5YU@204457|Sphingomonadales	204457|Sphingomonadales	U	Preprotein translocase subunit SecG	secG	-	-	ko:K03075	ko02024,ko03060,ko03070,map02024,map03060,map03070	M00335	-	-	ko00000,ko00001,ko00002,ko02044	3.A.5.1,3.A.5.2	-	-	SecG
HKD2_k127_604892_55	1123267.JONN01000001_gene1284	1.285e-89	301.0	COG0149@1|root,COG0149@2|Bacteria,1MWK5@1224|Proteobacteria,2TS6I@28211|Alphaproteobacteria,2K1PI@204457|Sphingomonadales	204457|Sphingomonadales	G	Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P)	tpiA	-	5.3.1.1	ko:K01803	ko00010,ko00051,ko00562,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00010,map00051,map00562,map00710,map01100,map01110,map01120,map01130,map01200,map01230	M00001,M00002,M00003	R01015	RC00423	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	TIM
HKD2_k127_604892_38	1123267.JONN01000001_gene1285	1.865e-132	446.0	COG0760@1|root,COG0760@2|Bacteria,1MWV0@1224|Proteobacteria,2TRYU@28211|Alphaproteobacteria,2K0KV@204457|Sphingomonadales	204457|Sphingomonadales	O	peptidylprolyl isomerase	-	-	5.2.1.8	ko:K01802,ko:K03770	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase_2,SurA_N_3
HKD2_k127_604892_93	35754.JNYJ01000033_gene2635	1.185e-31	126.0	COG5470@1|root,COG5470@2|Bacteria,2IMSF@201174|Actinobacteria,4DJ3V@85008|Micromonosporales	201174|Actinobacteria	S	NIPSNAP	-	-	-	-	-	-	-	-	-	-	-	-	NIPSNAP
HKD2_k127_604892_52	1123267.JONN01000001_gene1287	4.564e-100	329.0	COG1974@1|root,COG1974@2|Bacteria,1MW80@1224|Proteobacteria,2TT7W@28211|Alphaproteobacteria,2K1AX@204457|Sphingomonadales	204457|Sphingomonadales	K	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair	lexA	-	3.4.21.88	ko:K01356	-	M00729	-	-	ko00000,ko00002,ko01000,ko01002,ko03400	-	-	-	LexA_DNA_bind,Peptidase_S24
HKD2_k127_604892_79	1123267.JONN01000001_gene1313	1.093e-46	170.0	COG3324@1|root,COG3324@2|Bacteria,1N0AD@1224|Proteobacteria,2UD6F@28211|Alphaproteobacteria,2KDBW@204457|Sphingomonadales	204457|Sphingomonadales	S	glyoxalase bleomycin resistance protein dioxygenase	-	-	-	ko:K06996	-	-	-	-	ko00000	-	-	-	Glyoxalase
HKD2_k127_604892_16	1007104.SUS17_835	6.315e-217	682.0	COG0008@1|root,COG0008@2|Bacteria,1MUCR@1224|Proteobacteria,2TRSU@28211|Alphaproteobacteria,2K09A@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)	gltX1	-	6.1.1.17	ko:K01885	ko00860,ko00970,ko01100,ko01110,ko01120,map00860,map00970,map01100,map01110,map01120	M00121,M00359,M00360	R05578	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko02048,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_604892_13	1123267.JONN01000001_gene1317	4.572e-244	757.0	COG0372@1|root,COG0372@2|Bacteria,1MUKX@1224|Proteobacteria,2TS63@28211|Alphaproteobacteria,2K0JS@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the citrate synthase family	gltA	-	2.3.3.1	ko:K01647	ko00020,ko00630,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,map00020,map00630,map01100,map01110,map01120,map01130,map01200,map01210,map01230	M00009,M00010,M00012,M00740	R00351	RC00004,RC00067	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Citrate_synt
HKD2_k127_604892_54	1123267.JONN01000001_gene1318	7.421e-91	316.0	COG0642@1|root,COG2205@2|Bacteria,1NRP8@1224|Proteobacteria,2U3HG@28211|Alphaproteobacteria,2K0AE@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA
HKD2_k127_604892_78	1123267.JONN01000001_gene1319	9.573e-47	182.0	COG5330@1|root,COG5330@2|Bacteria	2|Bacteria	K	Evidence 4 Homologs of previously reported genes of	-	-	-	-	-	-	-	-	-	-	-	-	DUF2336,LRV,PSCyt2,PSD1,SHD1
HKD2_k127_604892_43	1123267.JONN01000001_gene1320	3.148e-119	395.0	2AKKZ@1|root,31BDD@2|Bacteria,1NNE3@1224|Proteobacteria,2UMPR@28211|Alphaproteobacteria,2K4ZT@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_604892_24	1123267.JONN01000001_gene1321	2.524e-192	625.0	COG1511@1|root,COG1511@2|Bacteria,1QVM2@1224|Proteobacteria,2TWI1@28211|Alphaproteobacteria,2KEGK@204457|Sphingomonadales	204457|Sphingomonadales	S	domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_604892_95	1123267.JONN01000001_gene1322	5.283e-30	121.0	COG5454@1|root,COG5454@2|Bacteria,1N8U9@1224|Proteobacteria,2UGCD@28211|Alphaproteobacteria,2K711@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1467)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1467
HKD2_k127_604892_12	1123267.JONN01000001_gene1323	8.898e-246	769.0	COG0595@1|root,COG0595@2|Bacteria,1MUGV@1224|Proteobacteria,2TQTR@28211|Alphaproteobacteria,2K04C@204457|Sphingomonadales	204457|Sphingomonadales	S	metallo-beta-lactamase	-	-	-	ko:K12574	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	Lactamase_B,Lactamase_B_2,RMMBL
HKD2_k127_604892_40	1123267.JONN01000001_gene1324	5.158e-122	396.0	COG1521@1|root,COG1521@2|Bacteria,1MUYA@1224|Proteobacteria,2TS5A@28211|Alphaproteobacteria,2K0SW@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis	coaX	-	2.7.1.33	ko:K03525	ko00770,ko01100,map00770,map01100	M00120	R02971,R03018,R04391	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Pan_kinase
HKD2_k127_604892_20	1292034.OR37_01224	4.297e-201	646.0	COG0492@1|root,COG2905@1|root,COG0492@2|Bacteria,COG2905@2|Bacteria,1MVX2@1224|Proteobacteria,2TQN3@28211|Alphaproteobacteria,2KI0S@204458|Caulobacterales	204458|Caulobacterales	C	Pyridine nucleotide-disulphide oxidoreductase	-	-	1.8.1.9	ko:K00384	ko00450,map00450	-	R02016,R03596,R09372	RC00013,RC02518,RC02873	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,cNMP_binding
HKD2_k127_604892_30	1449076.JOOE01000002_gene1243	3.133e-150	481.0	COG0596@1|root,COG0596@2|Bacteria,1MUVB@1224|Proteobacteria,2TREP@28211|Alphaproteobacteria,2JZYH@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha/beta hydrolase family	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_6
HKD2_k127_604892_34	864069.MicloDRAFT_00051970	2.059e-145	468.0	COG2267@1|root,COG2267@2|Bacteria,1MUG8@1224|Proteobacteria,2TRUA@28211|Alphaproteobacteria,1JQU4@119045|Methylobacteriaceae	28211|Alphaproteobacteria	I	PFAM alpha beta hydrolase fold	-	-	1.11.1.10	ko:K00433	-	-	-	-	ko00000,ko01000	-	-	-	Abhydrolase_1,Hydrolase_4
HKD2_k127_604892_66	1219049.SP5_007_00220	2.33e-59	215.0	COG0340@1|root,COG0340@2|Bacteria,1MWCC@1224|Proteobacteria,2TS82@28211|Alphaproteobacteria,2JZZZ@204457|Sphingomonadales	204457|Sphingomonadales	H	biotin lipoate A B protein ligase	birA	-	6.3.4.15	ko:K03524	ko00780,ko01100,map00780,map01100	-	R01074,R05145	RC00043,RC00070,RC00096,RC02896	ko00000,ko00001,ko01000,ko03000	-	-	-	BPL_C,BPL_LplA_LipB,BPL_LplA_LipB_2
HKD2_k127_604892_22	1123267.JONN01000001_gene1326	1.969e-195	627.0	COG1007@1|root,COG1007@2|Bacteria,1MV56@1224|Proteobacteria,2TQMX@28211|Alphaproteobacteria,2K08E@204457|Sphingomonadales	204457|Sphingomonadales	C	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient	nuoN	-	1.6.5.3	ko:K00343	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Proton_antipo_M
HKD2_k127_604892_15	1123267.JONN01000001_gene1327	2.417e-231	728.0	COG1008@1|root,COG1008@2|Bacteria,1MV7V@1224|Proteobacteria,2TSNK@28211|Alphaproteobacteria,2K0EQ@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH ubiquinone oxidoreductase subunit	nuoM	-	1.6.5.3	ko:K00342	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	Oxidored_q5_N,Proton_antipo_M
HKD2_k127_604892_86	1123267.JONN01000001_gene1328	1.258e-38	145.0	COG1009@1|root,COG1009@2|Bacteria,1MW2M@1224|Proteobacteria,2TQSS@28211|Alphaproteobacteria,2K1DM@204457|Sphingomonadales	204457|Sphingomonadales	CP	NADH ubiquinone oxidoreductase subunit	nuoL	-	1.6.5.3	ko:K00341	ko00190,ko01100,map00190,map01100	M00144	R11945	RC00061	ko00000,ko00001,ko00002,ko01000	3.D.1	-	-	NADH5_C,Proton_antipo_M,Proton_antipo_N
HKD2_k127_6253610_14	1123267.JONN01000001_gene1985	5.845e-11	66.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_6253610_9	69395.JQLZ01000001_gene3037	2.985e-32	132.0	2DTSK@1|root,32UVT@2|Bacteria,1N20S@1224|Proteobacteria,2UCXK@28211|Alphaproteobacteria,2KH1K@204458|Caulobacterales	204458|Caulobacterales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6253610_10	1123267.JONN01000001_gene1988	2.551e-24	103.0	COG3908@1|root,COG3908@2|Bacteria,1N7PA@1224|Proteobacteria,2UFTN@28211|Alphaproteobacteria,2K6ZC@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2093)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2093
HKD2_k127_6253610_3	1123267.JONN01000001_gene1989	2.154e-187	601.0	COG1570@1|root,COG1570@2|Bacteria,1MUA4@1224|Proteobacteria,2TR1R@28211|Alphaproteobacteria,2K05G@204457|Sphingomonadales	204457|Sphingomonadales	L	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides	xseA	-	3.1.11.6	ko:K03601	ko03430,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Exonuc_VII_L,tRNA_anti_2
HKD2_k127_6253610_2	1123267.JONN01000001_gene1990	5.811e-189	601.0	COG0151@1|root,COG0151@2|Bacteria,1MUAH@1224|Proteobacteria,2TQR5@28211|Alphaproteobacteria,2K0GD@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the GARS family	purD	-	6.3.4.13	ko:K01945	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04144	RC00090,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	GARS_A,GARS_C,GARS_N
HKD2_k127_6253610_8	1123267.JONN01000001_gene1993	3.417e-33	135.0	COG3743@1|root,COG3743@2|Bacteria,1N76A@1224|Proteobacteria,2U93Q@28211|Alphaproteobacteria,2KD7J@204457|Sphingomonadales	204457|Sphingomonadales	S	NADH ubiquinone oxidoreductase 41 kD complex I subunit	-	-	-	-	-	-	-	-	-	-	-	-	HHH_5
HKD2_k127_6253610_1	1123267.JONN01000001_gene2020	4.092e-203	640.0	COG1253@1|root,COG1253@2|Bacteria,1MV3P@1224|Proteobacteria,2TS80@28211|Alphaproteobacteria,2K087@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1253 Hemolysins and related proteins containing CBS domains	-	-	-	ko:K03699	-	-	-	-	ko00000,ko02042	-	-	-	CBS,CorC_HlyC,DUF21
HKD2_k127_6253610_7	1123267.JONN01000001_gene2019	1.896e-40	160.0	COG2885@1|root,COG2885@2|Bacteria,1MYBP@1224|Proteobacteria,2U787@28211|Alphaproteobacteria,2K074@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp,OmpA
HKD2_k127_6253610_5	1123267.JONN01000001_gene2018	1.078e-63	221.0	COG0590@1|root,COG0590@2|Bacteria,1RGU0@1224|Proteobacteria,2U77Q@28211|Alphaproteobacteria,2K4E6@204457|Sphingomonadales	204457|Sphingomonadales	FJ	Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2)	tadA	-	3.5.4.33	ko:K11991	-	-	R10223	RC00477	ko00000,ko01000,ko03016	-	-	-	MafB19-deam
HKD2_k127_6253610_6	317655.Sala_2750	6.033e-46	168.0	COG0227@1|root,COG0227@2|Bacteria,1MZ57@1224|Proteobacteria,2UBQU@28211|Alphaproteobacteria,2K561@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL28 family	rpmB	-	-	ko:K02902	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L28
HKD2_k127_6253610_4	745310.G432_14745	2.432e-64	225.0	COG2135@1|root,COG2135@2|Bacteria,1MY65@1224|Proteobacteria,2U39X@28211|Alphaproteobacteria,2K2FI@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the SOS response-associated peptidase family	-	-	-	-	-	-	-	-	-	-	-	-	SRAP
HKD2_k127_6253610_0	1123267.JONN01000001_gene2014	7.16e-274	853.0	COG4547@1|root,COG4547@2|Bacteria,1MX11@1224|Proteobacteria,2TS4N@28211|Alphaproteobacteria,2JZUK@204457|Sphingomonadales	204457|Sphingomonadales	H	Cobalamin biosynthesis protein CobT (nicotinate-mononucleotide 5, 6-dimethylbenzimidazole phosphoribosyltransferase)	-	-	6.6.1.2	ko:K09883	ko00860,ko01100,map00860,map01100	-	R05227	RC02000	ko00000,ko00001,ko01000	-	-	-	CobT,CobT_C
HKD2_k127_6253610_13	414684.RC1_3143	1.917e-15	81.0	COG2931@1|root,COG2931@2|Bacteria,1MU7T@1224|Proteobacteria,2TRVY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	COG2931 RTX toxins and related Ca2 -binding proteins	-	-	3.4.24.40	ko:K01406	ko01503,map01503	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	HCBP_related,HemolysinCabind,P_proprotein,Peptidase_M10,Peptidase_M10_C,Peptidase_S8,Reprolysin_4
HKD2_k127_6413617_0	1123060.JONP01000118_gene4238	3.958e-122	402.0	COG2801@1|root,COG2801@2|Bacteria,1MY62@1224|Proteobacteria,2U0GY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2801 Transposase and inactivated derivatives	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD2_k127_6413617_1	13689.BV96_03985	2.321e-49	179.0	COG2963@1|root,COG2963@2|Bacteria,1N0V0@1224|Proteobacteria,2VG35@28211|Alphaproteobacteria,2K5F5@204457|Sphingomonadales	204457|Sphingomonadales	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Tnp_1
HKD2_k127_6413617_2	316055.RPE_2435	1.463e-32	132.0	COG2963@1|root,COG2963@2|Bacteria,1RKI9@1224|Proteobacteria,2UDYB@28211|Alphaproteobacteria,3JZTB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	PFAM transposase IS3 IS911 family protein	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD2_k127_6413617_3	288000.BBta_6362	4.622e-12	69.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,3JZ4X@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	IS66 Orf2	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
HKD2_k127_6462295_5	863365.XHC_3767	6.253e-18	93.0	COG0367@1|root,COG0367@2|Bacteria,1Q8JT@1224|Proteobacteria,1T7TB@1236|Gammaproteobacteria,1X9PR@135614|Xanthomonadales	135614|Xanthomonadales	E	Asparagine synthase	-	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase
HKD2_k127_6462295_4	863365.XHC_3766	1.18e-23	109.0	2ENRK@1|root,33GCR@2|Bacteria,1Q819@1224|Proteobacteria,1T8IG@1236|Gammaproteobacteria,1XASJ@135614|Xanthomonadales	135614|Xanthomonadales	S	Transglutaminase-like superfamily	-	-	-	-	-	-	-	-	-	-	-	-	Transglut_core3
HKD2_k127_6462295_3	627192.SLG_26270	1.737e-40	156.0	COG1802@1|root,COG1802@2|Bacteria,1NFCK@1224|Proteobacteria,2UJ0B@28211|Alphaproteobacteria,2K5DR@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory proteins, gntR family	-	-	-	-	-	-	-	-	-	-	-	-	GntR
HKD2_k127_6462295_0	627192.SLG_26260	5.353e-129	419.0	COG5285@1|root,COG5285@2|Bacteria,1MXBX@1224|Proteobacteria,2TUI8@28211|Alphaproteobacteria,2K2FN@204457|Sphingomonadales	204457|Sphingomonadales	Q	Protein involved in biosynthesis of mitomycin antibiotics polyketide fumonisin	-	-	-	-	-	-	-	-	-	-	-	-	PhyH
HKD2_k127_6462295_2	1192759.AKIB01000015_gene1896	3.537e-67	236.0	COG3916@1|root,COG3916@2|Bacteria,1MXFA@1224|Proteobacteria,2U30F@28211|Alphaproteobacteria,2K2G7@204457|Sphingomonadales	204457|Sphingomonadales	H	Acyl-homoserine-lactone synthase	-	-	2.3.1.228,2.3.1.229	ko:K18096	ko02024,map02024	-	-	-	ko00000,ko00001,ko01000	-	-	-	Autoind_synth
HKD2_k127_6462295_1	1550073.JROH01000087_gene1939	2.412e-81	278.0	COG2771@1|root,COG2771@2|Bacteria,1R8XT@1224|Proteobacteria,2TW6C@28211|Alphaproteobacteria,2KEBZ@204457|Sphingomonadales	204457|Sphingomonadales	K	Autoinducer binding domain	-	-	-	ko:K19731	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	Autoind_bind,GerE
HKD2_k127_6462295_6	1174684.EBMC1_01955	5.155e-11	66.0	COG2197@1|root,COG2197@2|Bacteria,1PF54@1224|Proteobacteria,2V8KP@28211|Alphaproteobacteria,2K7EI@204457|Sphingomonadales	204457|Sphingomonadales	K	Bacterial regulatory proteins, luxR family	-	-	-	-	-	-	-	-	-	-	-	-	Autoind_bind,GerE
HKD2_k127_6463612_10	1123239.KB898630_gene2582	9.787e-05	45.0	2ED1A@1|root,336Y8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6463612_4	1123267.JONN01000001_gene716	2.54e-130	422.0	2CF7S@1|root,2ZB6P@2|Bacteria,1RF1X@1224|Proteobacteria,2TW2Z@28211|Alphaproteobacteria,2KE9J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6463612_9	745310.G432_18135	4.442e-32	128.0	COG3801@1|root,COG3801@2|Bacteria,1ND42@1224|Proteobacteria,2UMXK@28211|Alphaproteobacteria,2KDNW@204457|Sphingomonadales	204457|Sphingomonadales	S	YjbR	-	-	-	-	-	-	-	-	-	-	-	-	YjbR
HKD2_k127_6463612_2	1123267.JONN01000001_gene717	6.79e-163	524.0	2DBMQ@1|root,2Z9ZP@2|Bacteria,1QVZU@1224|Proteobacteria,2U5JS@28211|Alphaproteobacteria,2K406@204457|Sphingomonadales	204457|Sphingomonadales	S	Conserved TM helix	-	-	-	-	-	-	-	-	-	-	-	-	TM_helix
HKD2_k127_6463612_0	1449076.JOOE01000002_gene1052	4.609e-218	688.0	COG2256@1|root,COG2256@2|Bacteria,1MUVS@1224|Proteobacteria,2TQVF@28211|Alphaproteobacteria,2K1Z2@204457|Sphingomonadales	204457|Sphingomonadales	L	ATPase related to the helicase subunit of the Holliday junction resolvase	-	-	-	ko:K07478	-	-	-	-	ko00000	-	-	-	AAA,AAA_assoc_2,MgsA_C,RuvB_N
HKD2_k127_6463612_6	1545915.JROG01000004_gene2469	2.234e-56	203.0	COG1695@1|root,COG1695@2|Bacteria,1RHSE@1224|Proteobacteria,2U1HF@28211|Alphaproteobacteria,2K4SR@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_6463612_1	1123267.JONN01000001_gene720	5.781e-172	548.0	COG0438@1|root,COG0438@2|Bacteria,1MUB7@1224|Proteobacteria,2TQQ0@28211|Alphaproteobacteria,2K14F@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4,Glycos_transf_1
HKD2_k127_6463612_7	392499.Swit_3959	1.251e-45	169.0	COG3663@1|root,COG3663@2|Bacteria,1REPV@1224|Proteobacteria,2UE8H@28211|Alphaproteobacteria,2K6DA@204457|Sphingomonadales	204457|Sphingomonadales	L	Uracil-DNA glycosylase superfamily	-	-	-	-	-	-	-	-	-	-	-	-	UDG
HKD2_k127_6463612_5	935557.ATYB01000014_gene2624	5.474e-107	352.0	COG0695@1|root,COG0695@2|Bacteria,1MXQW@1224|Proteobacteria,2TT7R@28211|Alphaproteobacteria,4BB6T@82115|Rhizobiaceae	28211|Alphaproteobacteria	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin,MauE
HKD2_k127_6463612_3	1123267.JONN01000001_gene1278	6.347e-160	517.0	COG3667@1|root,COG3667@2|Bacteria,1R6TA@1224|Proteobacteria,2U52R@28211|Alphaproteobacteria,2K3M1@204457|Sphingomonadales	204457|Sphingomonadales	P	copper resistance	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6468136_15	5147.XP_003343440.1	1.962e-07	52.0	COG0093@1|root,KOG0901@2759|Eukaryota	2759|Eukaryota	J	large ribosomal subunit rRNA binding	-	-	-	-	-	-	-	-	-	-	-	-	Ribosomal_L14
HKD2_k127_6468136_13	1123267.JONN01000001_gene1548	2.476e-37	143.0	COG0186@1|root,COG0186@2|Bacteria,1MZIK@1224|Proteobacteria,2UBRF@28211|Alphaproteobacteria,2K5VH@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA	rpsQ	-	-	ko:K02961	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S17
HKD2_k127_6468136_14	745310.G432_08095	5.354e-23	102.0	COG0255@1|root,COG0255@2|Bacteria,1N6PR@1224|Proteobacteria,2UF59@28211|Alphaproteobacteria,2K6RZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the universal ribosomal protein uL29 family	rpmC	-	-	ko:K02904	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L29
HKD2_k127_6468136_7	1123267.JONN01000001_gene1550	2.867e-81	271.0	COG0197@1|root,COG0197@2|Bacteria,1RA0Z@1224|Proteobacteria,2U710@28211|Alphaproteobacteria,2K3Z0@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs	rplP	-	-	ko:K02878	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L16
HKD2_k127_6468136_3	1123267.JONN01000001_gene1551	1.314e-137	442.0	COG0092@1|root,COG0092@2|Bacteria,1MUAI@1224|Proteobacteria,2TRZ2@28211|Alphaproteobacteria,2K04S@204457|Sphingomonadales	204457|Sphingomonadales	J	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation	rpsC	-	-	ko:K02982	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	KH_2,Ribosomal_S3_C
HKD2_k127_6468136_9	1123267.JONN01000001_gene1552	5.735e-64	222.0	COG0091@1|root,COG0091@2|Bacteria,1RH0W@1224|Proteobacteria,2U96X@28211|Alphaproteobacteria,2K4K0@204457|Sphingomonadales	204457|Sphingomonadales	J	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome	rplV	-	-	ko:K02890	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L22
HKD2_k127_6468136_11	1470591.BW41_02088	1.007e-49	177.0	COG0185@1|root,COG0185@2|Bacteria,1RGYX@1224|Proteobacteria,2U95S@28211|Alphaproteobacteria,2K53B@204457|Sphingomonadales	204457|Sphingomonadales	J	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA	rpsS	-	-	ko:K02965	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S19
HKD2_k127_6468136_2	1090319.KE386571_gene1854	2.05e-164	518.0	COG0090@1|root,COG0090@2|Bacteria,1MVTD@1224|Proteobacteria,2TTKD@28211|Alphaproteobacteria,2JZZY@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity	rplB	-	-	ko:K02886	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L2,Ribosomal_L2_C
HKD2_k127_6468136_5	1123267.JONN01000001_gene1556	2.078e-106	347.0	COG0088@1|root,COG0088@2|Bacteria,1MXPF@1224|Proteobacteria,2TRUT@28211|Alphaproteobacteria,2K0RD@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the polypeptide exit tunnel	rplD	-	-	ko:K02926	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L4
HKD2_k127_6468136_4	1502850.FG91_02638	8.317e-115	377.0	COG0087@1|root,COG0087@2|Bacteria,1MUST@1224|Proteobacteria,2TRHB@28211|Alphaproteobacteria,2K0IE@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit	rplC	-	-	ko:K02906	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L3
HKD2_k127_6468136_10	264203.ZMO2003	9.73e-60	208.0	COG0051@1|root,COG0051@2|Bacteria,1RGWF@1224|Proteobacteria,2U95D@28211|Alphaproteobacteria,2K4QE@204457|Sphingomonadales	204457|Sphingomonadales	J	Involved in the binding of tRNA to the ribosomes	rpsJ	-	-	ko:K02946	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S10
HKD2_k127_6468136_1	1123267.JONN01000001_gene1562	4.846e-232	721.0	COG0050@1|root,COG0050@2|Bacteria,1MVC0@1224|Proteobacteria,2TQP8@28211|Alphaproteobacteria,2K177@204457|Sphingomonadales	204457|Sphingomonadales	J	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis	tuf	-	-	ko:K02358	-	-	-	-	ko00000,ko03012,ko03029,ko04147	-	-	-	GTP_EFTU,GTP_EFTU_D2,GTP_EFTU_D3
HKD2_k127_6468136_0	1123267.JONN01000001_gene1563	0.0	1250.0	COG0480@1|root,COG0480@2|Bacteria,1MUCV@1224|Proteobacteria,2TQVI@28211|Alphaproteobacteria,2K04N@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome	fusA	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_6468136_6	629773.AORY01000004_gene510	2.111e-86	287.0	COG0049@1|root,COG0049@2|Bacteria,1MXC8@1224|Proteobacteria,2TSI8@28211|Alphaproteobacteria,2K0I9@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA	rpsG	-	-	ko:K02992	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S7
HKD2_k127_6468136_8	1030157.AFMP01000051_gene343	8.2e-75	253.0	COG0048@1|root,COG0048@2|Bacteria,1RCWY@1224|Proteobacteria,2U70K@28211|Alphaproteobacteria,2K3W8@204457|Sphingomonadales	204457|Sphingomonadales	J	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit	rpsL	-	-	ko:K02950	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosom_S12_S23
HKD2_k127_6471135_1	317655.Sala_2288	7.471e-163	514.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2K03H@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_6471135_3	1123267.JONN01000002_gene7	1.557e-30	124.0	COG0355@1|root,COG0355@2|Bacteria,1RHE4@1224|Proteobacteria,2UBXX@28211|Alphaproteobacteria,2K5WN@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane	atpC	-	-	ko:K02113,ko:K02114	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt_DE_N
HKD2_k127_6471135_2	685778.AORL01000010_gene3149	3.827e-140	468.0	28NF3@1|root,2ZBHG@2|Bacteria,1N046@1224|Proteobacteria,2U3EA@28211|Alphaproteobacteria,2KDNV@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6471135_4	685778.AORL01000010_gene3148	7.832e-24	113.0	2D5UT@1|root,32R54@2|Bacteria,1MYAG@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6471135_0	1123267.JONN01000002_gene5	9.321e-269	834.0	COG4962@1|root,COG4962@2|Bacteria,1R7EN@1224|Proteobacteria,2TRNT@28211|Alphaproteobacteria,2K008@204457|Sphingomonadales	204457|Sphingomonadales	U	Flp pilus assembly protein, ATPase CpaF	-	-	-	ko:K02283	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	T2SSE
HKD2_k127_6471135_5	84531.JMTZ01000033_gene260	1.243e-12	70.0	2C5JX@1|root,32WNU@2|Bacteria,1NUC9@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6551499_6	991905.SL003B_1984	5.894e-44	165.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,4BR2P@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	K	Cold shock protein domain	cspB	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_6551499_1	1230476.C207_01425	2.625e-116	379.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,3JTG8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form	MA20_30275	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD2_k127_6551499_5	1187851.A33M_0888	9.22e-73	247.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,3FD78@34008|Rhodovulum	28211|Alphaproteobacteria	E	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily	gloA	GO:0003674,GO:0003824,GO:0004462,GO:0006518,GO:0006575,GO:0006749,GO:0006790,GO:0006807,GO:0008150,GO:0008152,GO:0009987,GO:0016829,GO:0016846,GO:0034641,GO:0043603,GO:0044237,GO:0051186,GO:0071704,GO:1901564	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_6551499_8	202952.BBLI01000008_gene828	4.389e-05	46.0	2DTNT@1|root,33M3P@2|Bacteria,1NH3S@1224|Proteobacteria,1SGZB@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6551499_7	1123229.AUBC01000028_gene2263	1.088e-13	74.0	2E09K@1|root,32VX5@2|Bacteria,1N5Z5@1224|Proteobacteria,2UCIG@28211|Alphaproteobacteria,3JZVS@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6551499_2	460265.Mnod_2124	6.478e-91	309.0	COG0760@1|root,COG0760@2|Bacteria,1RDD3@1224|Proteobacteria,2U3I3@28211|Alphaproteobacteria,1JTJR@119045|Methylobacteriaceae	28211|Alphaproteobacteria	G	PFAM PpiC-type peptidyl-prolyl cis-trans isomerase	-	-	5.2.1.8	ko:K03769	-	-	-	-	ko00000,ko01000,ko03110	-	-	-	Rotamase,Rotamase_3
HKD2_k127_6551499_0	1267005.KB911266_gene1224	8.489e-126	409.0	COG2181@1|root,COG2181@2|Bacteria,1MXGZ@1224|Proteobacteria,2TTDB@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	nitrate reductase, gamma subunit	narI	-	1.7.5.1	ko:K00374	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Nitrate_red_gam
HKD2_k127_6551499_4	883080.HMPREF9697_03521	5.301e-76	263.0	COG2180@1|root,COG2180@2|Bacteria,1MY4E@1224|Proteobacteria,2U19T@28211|Alphaproteobacteria,3JWFB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Nitrate reductase delta subunit	narJ	-	-	ko:K00373	ko02020,map02020	-	-	-	ko00000,ko00001	-	-	-	Nitrate_red_del
HKD2_k127_6551499_3	1267005.KB911266_gene1222	5.241e-80	268.0	COG1140@1|root,COG1140@2|Bacteria,1MW9Q@1224|Proteobacteria,2TYWX@28211|Alphaproteobacteria,3N9D2@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	C	Nitrate reductase beta subunit	narH	-	1.7.5.1	ko:K00371	ko00910,ko01120,ko02020,map00910,map01120,map02020	M00529,M00530,M00804	R00798,R01106,R09497	RC02812	ko00000,ko00001,ko00002,ko01000	5.A.3.1	-	-	Fer4_11,Nitr_red_bet_C
HKD2_k127_6627667_11	1041142.ATTP01000007_gene6103	7.757e-95	321.0	COG1226@1|root,COG1226@2|Bacteria,1MV0T@1224|Proteobacteria,2UB9U@28211|Alphaproteobacteria,4BCC9@82115|Rhizobiaceae	28211|Alphaproteobacteria	P	Castor and Pollux, part of voltage-gated ion channel	dMI1	-	-	-	-	-	-	-	-	-	-	-	Castor_Poll_mid
HKD2_k127_6627667_21	1229205.BUPH_08223	1.283e-10	66.0	2E5SP@1|root,330H2@2|Bacteria,1NDBY@1224|Proteobacteria,2VXDV@28216|Betaproteobacteria,1K76Z@119060|Burkholderiaceae	28216|Betaproteobacteria	S	YMGG-like Gly-zipper	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_YMGG
HKD2_k127_6627667_15	1027273.GZ77_08910	4.175e-17	84.0	2EC8I@1|root,33670@2|Bacteria,1NH09@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6627667_4	1163407.UU7_08503	1.221e-179	576.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,1RN9J@1236|Gammaproteobacteria,1X3AX@135614|Xanthomonadales	135614|Xanthomonadales	M	outer membrane efflux protein	-	-	-	-	-	-	-	-	-	-	-	-	OEP
HKD2_k127_6627667_9	666685.R2APBS1_3419	9.712e-105	351.0	COG0845@1|root,COG0845@2|Bacteria,1MVAS@1224|Proteobacteria,1RWJY@1236|Gammaproteobacteria,1X3Z5@135614|Xanthomonadales	135614|Xanthomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K15727	-	-	-	-	ko00000,ko02000	8.A.1.2.1	-	-	HlyD_D23
HKD2_k127_6627667_0	1163407.UU7_08493	0.0	1527.0	COG3696@1|root,COG3696@2|Bacteria,1NUIV@1224|Proteobacteria,1RNST@1236|Gammaproteobacteria,1XCEU@135614|Xanthomonadales	135614|Xanthomonadales	P	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family	-	-	-	ko:K15726	-	-	-	-	ko00000,ko02000	2.A.6.1.2	-	-	ACR_tran
HKD2_k127_6627667_10	1161401.ASJA01000005_gene2430	5.776e-99	333.0	COG1446@1|root,COG4242@1|root,COG1446@2|Bacteria,COG4242@2|Bacteria,1MWFC@1224|Proteobacteria,2TU8K@28211|Alphaproteobacteria,43WRE@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	asparaginase	iaaA	-	3.4.19.5,3.5.1.1	ko:K01424,ko:K13051	ko00250,ko00460,ko01100,ko01110,map00250,map00460,map01100,map01110	-	R00485	RC00010,RC02798	ko00000,ko00001,ko01000,ko01002	-	-	-	Asparaginase_2,Peptidase_S51
HKD2_k127_6627667_1	1123267.JONN01000001_gene2297	0.0	1127.0	COG0612@1|root,COG0612@2|Bacteria,1MVST@1224|Proteobacteria,2TRFB@28211|Alphaproteobacteria,2K05M@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase, M16	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M16,Peptidase_M16_C
HKD2_k127_6627667_19	1267533.KB906734_gene3979	1.079e-13	78.0	2A09E@1|root,30NCR@2|Bacteria,3Y8XP@57723|Acidobacteria,2JNU4@204432|Acidobacteriia	204432|Acidobacteriia	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6627667_22	419610.Mext_0790	0.0004873	46.0	2DFRH@1|root,2ZST4@2|Bacteria,1P4MA@1224|Proteobacteria,2UXAZ@28211|Alphaproteobacteria,1JWPJ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6627667_6	1123267.JONN01000001_gene2299	2.337e-143	463.0	COG0026@1|root,COG0026@2|Bacteria,1MU70@1224|Proteobacteria,2TRSV@28211|Alphaproteobacteria,2K0ZI@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)	purK	-	6.3.4.18	ko:K01589	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07404	RC01927	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD2_k127_6627667_12	745310.G432_10005	1.651e-74	254.0	COG0041@1|root,COG0041@2|Bacteria,1RCWJ@1224|Proteobacteria,2U58D@28211|Alphaproteobacteria,2K3Z8@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)	purE	-	5.4.99.18	ko:K01588	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R07405	RC01947	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRC
HKD2_k127_6627667_13	1123267.JONN01000001_gene2301	1.515e-57	207.0	COG2199@1|root,COG2199@2|Bacteria,1Q7FU@1224|Proteobacteria,2TRE7@28211|Alphaproteobacteria,2K6NS@204457|Sphingomonadales	204457|Sphingomonadales	T	diguanylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	GGDEF
HKD2_k127_6627667_8	627192.SLG_05370	4.25e-109	356.0	COG0588@1|root,COG0588@2|Bacteria,1MUVE@1224|Proteobacteria,2TSQ0@28211|Alphaproteobacteria,2K06W@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily	gpmA	-	5.4.2.11	ko:K01834	ko00010,ko00260,ko00680,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko05230,map00010,map00260,map00680,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map05230	M00001,M00002,M00003	R01518	RC00536	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	His_Phos_1
HKD2_k127_6627667_3	1123267.JONN01000001_gene2293	1.47e-182	577.0	COG2866@1|root,COG2866@2|Bacteria,1MUMN@1224|Proteobacteria,2TREN@28211|Alphaproteobacteria,2K01Q@204457|Sphingomonadales	204457|Sphingomonadales	E	Carboxypeptidase	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M14
HKD2_k127_6627667_7	1123267.JONN01000001_gene2316	5.21e-142	457.0	COG1087@1|root,COG1087@2|Bacteria,1MUHI@1224|Proteobacteria,2TTC7@28211|Alphaproteobacteria,2K1G3@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the NAD(P)-dependent epimerase dehydratase family	galE	-	5.1.3.2	ko:K01784	ko00052,ko00520,ko01100,map00052,map00520,map01100	M00361,M00362,M00632	R00291,R02984	RC00289	ko00000,ko00001,ko00002,ko01000	-	-	-	Epimerase
HKD2_k127_6627667_14	1123267.JONN01000001_gene2265	1.2e-23	107.0	COG3577@1|root,COG3577@2|Bacteria,1MZCI@1224|Proteobacteria,2U9K2@28211|Alphaproteobacteria,2K6WM@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HKD2_k127_6627667_2	1281779.H009_13216	6.534e-234	752.0	COG0784@1|root,COG2461@1|root,COG4191@1|root,COG0784@2|Bacteria,COG2461@2|Bacteria,COG4191@2|Bacteria,1RCM9@1224|Proteobacteria,2TQQ9@28211|Alphaproteobacteria,4B880@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA,PAS_4,PAS_9,Response_reg
HKD2_k127_6627667_17	161528.ED21_22698	1.089e-15	78.0	COG0257@1|root,COG0257@2|Bacteria,1NGBJ@1224|Proteobacteria,2UJAG@28211|Alphaproteobacteria,2K7QY@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL36 family	rpmJ	-	-	ko:K02919	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L36
HKD2_k127_6627667_20	555217.Zmob_1234	3.694e-12	73.0	2ANHM@1|root,31DGD@2|Bacteria,1PBN5@1224|Proteobacteria,2UX1C@28211|Alphaproteobacteria,2K77Q@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6627667_5	1123267.JONN01000001_gene2322	4.991e-163	520.0	COG0027@1|root,COG0027@2|Bacteria,1N3KA@1224|Proteobacteria,2TVIF@28211|Alphaproteobacteria,2K0X5@204457|Sphingomonadales	204457|Sphingomonadales	F	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate	purT	-	2.1.2.2	ko:K08289	ko00230,ko00670,ko01100,ko01110,ko01130,map00230,map00670,map01100,map01110,map01130	M00048	R04325,R04326	RC00026,RC00197,RC01128	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp
HKD2_k127_6781253_5	28444.JODQ01000013_gene2871	9.016e-09	66.0	COG3247@1|root,COG3247@2|Bacteria,2I119@201174|Actinobacteria,4EJMN@85012|Streptosporangiales	201174|Actinobacteria	S	Short repeat of unknown function (DUF308)	-	-	-	-	-	-	-	-	-	-	-	-	DUF308
HKD2_k127_6781253_3	1128421.JAGA01000003_gene2786	1.547e-43	166.0	COG1881@1|root,COG1881@2|Bacteria,2NPMM@2323|unclassified Bacteria	2|Bacteria	S	Phosphatidylethanolamine-binding protein	-	-	-	ko:K06910	-	-	-	-	ko00000	-	-	-	PBP
HKD2_k127_6781253_1	1248916.ANFY01000007_gene2589	1.2e-90	305.0	2C3PP@1|root,2Z954@2|Bacteria,1MXGR@1224|Proteobacteria,2TS01@28211|Alphaproteobacteria,2K2TC@204457|Sphingomonadales	204457|Sphingomonadales	S	Branched-chain amino acid aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_6781253_0	1044.EH31_01905	1.203e-143	461.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TQR9@28211|Alphaproteobacteria,2K6X7@204457|Sphingomonadales	204457|Sphingomonadales	EH	Amino-transferase class IV	-	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_6781253_2	1123267.JONN01000001_gene1569	1.574e-55	198.0	COG0662@1|root,COG0662@2|Bacteria,1RJ7D@1224|Proteobacteria,2UAG4@28211|Alphaproteobacteria,2K4M6@204457|Sphingomonadales	204457|Sphingomonadales	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_6781253_4	1194165.CAJF01000021_gene3028	3.498e-39	150.0	2CGGQ@1|root,32S3Z@2|Bacteria,2IQ59@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF3140)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3140
HKD2_k127_6826463_2	1123267.JONN01000002_gene246	1.193e-87	293.0	COG5385@1|root,COG5385@2|Bacteria,1MVEY@1224|Proteobacteria,2TSE6@28211|Alphaproteobacteria,2K0H0@204457|Sphingomonadales	204457|Sphingomonadales	S	Histidine phosphotransferase C-terminal domain	-	-	-	ko:K13588	ko02020,ko04112,map02020,map04112	-	-	-	ko00000,ko00001	-	-	-	HPTransfase
HKD2_k127_6826463_1	1123267.JONN01000002_gene245	6.564e-152	484.0	COG0564@1|root,COG0564@2|Bacteria,1MUBN@1224|Proteobacteria,2TSBK@28211|Alphaproteobacteria,2K1VU@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for synthesis of pseudouridine from uracil	rluD	-	5.4.99.23	ko:K06180	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_6826463_0	1123267.JONN01000002_gene244	2.003e-167	529.0	COG0568@1|root,COG0568@2|Bacteria,1MVWR@1224|Proteobacteria,2TR9Q@28211|Alphaproteobacteria,2K1G6@204457|Sphingomonadales	204457|Sphingomonadales	K	RNA polymerase sigma	rpoH	-	-	ko:K03089	-	-	-	-	ko00000,ko03021	-	-	-	Sigma70_r1_2,Sigma70_r2,Sigma70_r4
HKD2_k127_6826463_3	1123267.JONN01000002_gene242	3.518e-54	193.0	COG0480@1|root,COG0480@2|Bacteria,1MU2W@1224|Proteobacteria,2TYVK@28211|Alphaproteobacteria,2K1XU@204457|Sphingomonadales	204457|Sphingomonadales	J	Elongation factor G, domain IV	-	-	-	ko:K02355	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EFG_C,EFG_II,EFG_IV,GTP_EFTU
HKD2_k127_6930297_4	864069.MicloDRAFT_00004370	7.588e-33	131.0	COG2963@1|root,COG2963@2|Bacteria,1N7V0@1224|Proteobacteria,2UFGY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07483	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD2_k127_6930297_3	693986.MOC_5438	6.99e-67	228.0	COG3436@1|root,COG3436@2|Bacteria,1RHDW@1224|Proteobacteria,2U7TH@28211|Alphaproteobacteria,1JXXB@119045|Methylobacteriaceae	28211|Alphaproteobacteria	L	IS66 Orf2 like protein	-	-	-	ko:K07484	-	-	-	-	ko00000	-	-	-	TnpB_IS66
HKD2_k127_6930297_0	648757.Rvan_2671	4.664e-268	833.0	COG4372@1|root,COG4372@2|Bacteria,1MUCX@1224|Proteobacteria,2TR59@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_IS66,DDE_Tnp_IS66_C,LZ_Tnp_IS66,zf-IS66
HKD2_k127_6930297_1	323097.Nham_2989	4.717e-92	305.0	COG4974@1|root,COG4974@2|Bacteria,1MZES@1224|Proteobacteria,2TVGW@28211|Alphaproteobacteria,3JTJW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Plasmid pRiA4b ORF-3-like protein	-	-	-	-	-	-	-	-	-	-	-	-	PRiA4_ORF3
HKD2_k127_6930297_5	330214.NIDE1789	1.56e-28	115.0	COG3293@1|root,COG3293@2|Bacteria	2|Bacteria	L	Transposase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4096,Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_6930297_2	1037409.BJ6T_83010	1.049e-90	299.0	COG3293@1|root,COG3293@2|Bacteria,1NCPP@1224|Proteobacteria	1224|Proteobacteria	L	Transposase proposed to express due to -1 translational frameshift at the sequence 5'-AAAAAC-3'	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1,DUF4096
HKD2_k127_7386290_4	1038859.AXAU01000001_gene2875	2.785e-09	61.0	COG0457@1|root,COG3710@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3710@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,3JR8W@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	TPR_8,Trans_reg_C
HKD2_k127_7386290_0	2074.JNYD01000015_gene4604	4.616e-129	430.0	COG3848@1|root,COG3848@2|Bacteria,2H2J1@201174|Actinobacteria	201174|Actinobacteria	T	PEP-utilising enzyme, mobile domain	-	-	2.7.9.2	ko:K01007	ko00620,ko00680,ko00720,ko01100,ko01120,ko01200,map00620,map00680,map00720,map01100,map01120,map01200	M00173,M00374	R00199	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000	-	-	-	PEP-utilizers
HKD2_k127_7386290_1	1192034.CAP_2543	1.959e-69	251.0	COG0574@1|root,COG0574@2|Bacteria,1Q9MN@1224|Proteobacteria,434GW@68525|delta/epsilon subdivisions,2WYU9@28221|Deltaproteobacteria,2Z0MI@29|Myxococcales	28221|Deltaproteobacteria	G	Pyruvate phosphate dikinase, PEP/pyruvate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	PPDK_N
HKD2_k127_7386290_2	1229780.BN381_90008	2.75e-16	91.0	COG0664@1|root,COG0664@2|Bacteria,2GYD2@201174|Actinobacteria	201174|Actinobacteria	T	Cyclic nucleotide-monophosphate binding domain	-	-	-	-	-	-	-	-	-	-	-	-	cNMP_binding
HKD2_k127_7386290_3	318996.AXAZ01000117_gene770	3.981e-10	65.0	29I16@1|root,304Y9@2|Bacteria,1RJH5@1224|Proteobacteria,2UA93@28211|Alphaproteobacteria,3JZYB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_6	1123267.JONN01000001_gene1985	1.553e-245	775.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_7682088_59	1449076.JOOE01000003_gene3575	1.985e-69	249.0	COG2972@1|root,COG2972@2|Bacteria,1MXVQ@1224|Proteobacteria,2U103@28211|Alphaproteobacteria,2K0W4@204457|Sphingomonadales	204457|Sphingomonadales	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	His_kinase
HKD2_k127_7682088_60	1449076.JOOE01000003_gene3574	6.332e-68	239.0	COG3279@1|root,COG3279@2|Bacteria,1MUE8@1224|Proteobacteria,2U0M2@28211|Alphaproteobacteria,2K2B0@204457|Sphingomonadales	204457|Sphingomonadales	KT	Response regulator of the LytR AlgR family	-	-	-	-	-	-	-	-	-	-	-	-	LytTR,Response_reg
HKD2_k127_7682088_49	216596.RL0486	1.953e-83	285.0	COG0457@1|root,COG0457@2|Bacteria,1RJ8H@1224|Proteobacteria,2UANA@28211|Alphaproteobacteria,4BBGS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_85	452662.SJA_C1-11010	2.397e-05	49.0	2DTVP@1|root,33MV8@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_46	948106.AWZT01000015_gene690	8.4e-90	301.0	COG0546@1|root,COG0546@2|Bacteria,1QTZ0@1224|Proteobacteria,2VMZN@28216|Betaproteobacteria,1K0BV@119060|Burkholderiaceae	28216|Betaproteobacteria	S	TIGRFAM HAD-superfamily hydrolase, subfamily IA, variant 3	-	-	-	-	-	-	-	-	-	-	-	-	HAD_2
HKD2_k127_7682088_16	633149.Bresu_1163	1.18e-185	588.0	COG0477@1|root,COG0477@2|Bacteria,1MU46@1224|Proteobacteria,2TQVP@28211|Alphaproteobacteria,2KIDT@204458|Caulobacterales	204458|Caulobacterales	EGP	Sugar (and other) transporter	-	-	-	ko:K03762	-	-	-	-	ko00000,ko02000	2.A.1.6.4	-	-	MFS_1,Sugar_tr
HKD2_k127_7682088_20	1123267.JONN01000001_gene970	4.128e-155	501.0	COG2148@1|root,COG2148@2|Bacteria,1MV6W@1224|Proteobacteria,2U148@28211|Alphaproteobacteria,2KD5X@204457|Sphingomonadales	204457|Sphingomonadales	M	Bacterial sugar transferase	-	-	2.7.8.40	ko:K21303	-	-	-	-	ko00000,ko01000,ko01003,ko01005	-	-	-	Bac_transf
HKD2_k127_7682088_17	392499.Swit_1201	4.106e-179	569.0	COG0677@1|root,COG0677@2|Bacteria,1MUC6@1224|Proteobacteria,2TR5F@28211|Alphaproteobacteria,2K04J@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.136	ko:K02474,ko:K13015	ko00520,map00520	-	R00421,R06894	RC00291	ko00000,ko00001,ko01000,ko01005	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_7682088_10	1123267.JONN01000002_gene68	1.058e-197	624.0	COG1004@1|root,COG1004@2|Bacteria,1MW5U@1224|Proteobacteria,2TREV@28211|Alphaproteobacteria,2K1AN@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the UDP-glucose GDP-mannose dehydrogenase family	-	-	1.1.1.22	ko:K00012	ko00040,ko00053,ko00520,ko01100,map00040,map00053,map00520,map01100	M00014,M00129,M00361,M00362	R00286	RC00291	ko00000,ko00001,ko00002,ko01000	-	-	-	UDPG_MGDP_dh,UDPG_MGDP_dh_C,UDPG_MGDP_dh_N
HKD2_k127_7682088_9	1123269.NX02_11060	1.801e-224	702.0	COG0621@1|root,COG0621@2|Bacteria,1MU7N@1224|Proteobacteria,2TQUS@28211|Alphaproteobacteria,2K1QA@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12	rimO	-	2.8.4.4	ko:K14441	-	-	R10652	RC00003,RC03217	ko00000,ko01000,ko03009	-	-	-	Radical_SAM,TRAM,UPF0004
HKD2_k127_7682088_57	366602.Caul_1957	3.397e-73	259.0	COG0628@1|root,COG0628@2|Bacteria,1MXXU@1224|Proteobacteria,2TQJJ@28211|Alphaproteobacteria,2KF24@204458|Caulobacterales	204458|Caulobacterales	S	AI-2E family transporter	-	-	-	-	-	-	-	-	-	-	-	-	AI-2E_transport
HKD2_k127_7682088_14	1123267.JONN01000001_gene669	2.383e-188	598.0	COG0260@1|root,COG0260@2|Bacteria,1MUIN@1224|Proteobacteria,2TSI6@28211|Alphaproteobacteria,2JZV7@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the peptidase M17 family	-	-	3.4.11.1	ko:K01255	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_M17
HKD2_k127_7682088_67	1123267.JONN01000001_gene668	1.019e-58	207.0	COG1846@1|root,COG1846@2|Bacteria,1RJNN@1224|Proteobacteria,2U9SQ@28211|Alphaproteobacteria,2KDEK@204457|Sphingomonadales	204457|Sphingomonadales	K	Winged helix DNA-binding domain	-	-	-	-	-	-	-	-	-	-	-	-	MarR,MarR_2
HKD2_k127_7682088_82	392499.Swit_0096	9.459e-18	89.0	COG0791@1|root,COG0791@2|Bacteria,1MW03@1224|Proteobacteria,2TSFG@28211|Alphaproteobacteria,2K27W@204457|Sphingomonadales	204457|Sphingomonadales	M	NlpC/P60 family	-	-	-	-	-	-	-	-	-	-	-	-	NLPC_P60
HKD2_k127_7682088_36	1234595.C725_0885	3.824e-113	374.0	COG1559@1|root,COG1559@2|Bacteria,1MUQF@1224|Proteobacteria,2TR89@28211|Alphaproteobacteria,4BPJD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	S	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation	mltG	-	-	ko:K07082	-	-	-	-	ko00000	-	-	-	YceG
HKD2_k127_7682088_7	1219049.SP5_005_00330	1.609e-241	751.0	COG0304@1|root,COG0304@2|Bacteria,1MU1X@1224|Proteobacteria,2TR32@28211|Alphaproteobacteria,2JZXI@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP	fabF	-	2.3.1.179	ko:K09458	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04355,R04726,R04952,R04957,R04960,R04963,R04968,R07762,R10115,R10119	RC00039,RC02728,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	Ketoacyl-synt_C,ketoacyl-synt
HKD2_k127_7682088_78	1549858.MC45_04350	5.975e-37	141.0	COG0236@1|root,COG0236@2|Bacteria,1MZ4P@1224|Proteobacteria,2UBWW@28211|Alphaproteobacteria,2K5X6@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Carrier of the growing fatty acid chain in fatty acid biosynthesis	acpP	-	-	ko:K02078	-	-	-	-	ko00000,ko00001	-	-	-	PP-binding
HKD2_k127_7682088_70	1346791.M529_12505	8.547e-53	191.0	COG4253@1|root,COG4253@2|Bacteria,1RFXU@1224|Proteobacteria,2US4C@28211|Alphaproteobacteria,2KDWZ@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_3	1123267.JONN01000001_gene662	1.263e-309	973.0	COG1629@1|root,COG4771@2|Bacteria,1MVFB@1224|Proteobacteria,2U1V9@28211|Alphaproteobacteria,2KEE4@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_7682088_19	1123267.JONN01000001_gene661	4.595e-165	528.0	COG0665@1|root,COG0665@2|Bacteria,1MU7M@1224|Proteobacteria,2U3N5@28211|Alphaproteobacteria,2K4RF@204457|Sphingomonadales	204457|Sphingomonadales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD2_k127_7682088_66	1123267.JONN01000001_gene660	1.385e-60	214.0	COG0576@1|root,COG0576@2|Bacteria,1RH8T@1224|Proteobacteria,2U5V2@28211|Alphaproteobacteria,2K3XC@204457|Sphingomonadales	204457|Sphingomonadales	O	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ	grpE	-	-	ko:K03687	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	GrpE
HKD2_k127_7682088_24	1123267.JONN01000001_gene659	1.213e-146	471.0	COG1420@1|root,COG1420@2|Bacteria,1MVX4@1224|Proteobacteria,2TRUF@28211|Alphaproteobacteria,2K03N@204457|Sphingomonadales	204457|Sphingomonadales	K	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons	hrcA	-	-	ko:K03705	-	-	-	-	ko00000,ko03000	-	-	-	HrcA,HrcA_DNA-bdg
HKD2_k127_7682088_33	452662.SJA_C1-10660	1.202e-121	393.0	COG0689@1|root,COG0689@2|Bacteria,1MVFZ@1224|Proteobacteria,2TRMC@28211|Alphaproteobacteria,2K0PW@204457|Sphingomonadales	204457|Sphingomonadales	J	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates	rph	-	2.7.7.56	ko:K00989	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	RNase_PH,RNase_PH_C
HKD2_k127_7682088_51	1123267.JONN01000001_gene657	2.694e-80	275.0	COG0127@1|root,COG0127@2|Bacteria,1MUK5@1224|Proteobacteria,2TV4B@28211|Alphaproteobacteria,2K1NS@204457|Sphingomonadales	204457|Sphingomonadales	F	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions	rdgB	-	3.6.1.66	ko:K02428	ko00230,map00230	-	R00426,R00720,R01855,R02100,R02720,R03531	RC00002	ko00000,ko00001,ko01000	-	-	-	Ham1p_like
HKD2_k127_7682088_18	1123267.JONN01000001_gene656	1.017e-177	564.0	COG0635@1|root,COG0635@2|Bacteria,1MU76@1224|Proteobacteria,2TT63@28211|Alphaproteobacteria,2K09I@204457|Sphingomonadales	204457|Sphingomonadales	H	Involved in the biosynthesis of porphyrin-containing compound	-	-	-	-	-	-	-	-	-	-	-	-	HemN_C,Radical_SAM
HKD2_k127_7682088_42	1123267.JONN01000001_gene653	2.433e-101	337.0	COG0313@1|root,COG0313@2|Bacteria,1MU0E@1224|Proteobacteria,2TR14@28211|Alphaproteobacteria,2K0AW@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA	rsmI	-	2.1.1.198	ko:K07056	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	TP_methylase
HKD2_k127_7682088_22	1379701.JPJC01000252_gene1899	3.57e-149	477.0	COG0189@1|root,COG0189@2|Bacteria,1MVUA@1224|Proteobacteria,2TQNE@28211|Alphaproteobacteria,2K0JQ@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the prokaryotic GSH synthase family	gshB	-	6.3.2.3	ko:K01920	ko00270,ko00480,ko01100,map00270,map00480,map01100	M00118	R00497,R10994	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	GSH-S_ATP,GSH-S_N
HKD2_k127_7682088_35	1123267.JONN01000001_gene648	7.653e-114	376.0	COG4974@1|root,COG4974@2|Bacteria,1QU6A@1224|Proteobacteria,2TS7W@28211|Alphaproteobacteria,2K1R3@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the 'phage' integrase family	xerC_2	-	-	ko:K03733	-	-	-	-	ko00000,ko03036	-	-	-	Phage_int_SAM_1,Phage_integrase
HKD2_k127_7682088_65	685778.AORL01000010_gene3162	6.539e-64	224.0	COG3159@1|root,COG3159@2|Bacteria,1Q6ZX@1224|Proteobacteria,2VD3T@28211|Alphaproteobacteria,2K427@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function, DUF484	-	-	-	ko:K09921	-	-	-	-	ko00000	-	-	-	DUF484
HKD2_k127_7682088_83	1081640.AGFU01000009_gene1461	3.281e-15	76.0	COG3847@1|root,COG3847@2|Bacteria,1Q1G3@1224|Proteobacteria,2V11R@28211|Alphaproteobacteria,2K7TI@204457|Sphingomonadales	204457|Sphingomonadales	U	Flp pilus assembly protein, pilin Flp	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HKD2_k127_7682088_38	1123267.JONN01000001_gene646	2.632e-111	363.0	COG0176@1|root,COG0176@2|Bacteria,1MWQ8@1224|Proteobacteria,2TQJB@28211|Alphaproteobacteria,2K0F2@204457|Sphingomonadales	204457|Sphingomonadales	G	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway	tal	-	2.2.1.2	ko:K00616	ko00030,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,map00030,map01100,map01110,map01120,map01130,map01200,map01230	M00004,M00007	R01827	RC00439,RC00604	ko00000,ko00001,ko00002,ko01000	-	-	-	TAL_FSA
HKD2_k127_7682088_44	1123267.JONN01000001_gene645	2.095e-90	304.0	COG1024@1|root,COG1024@2|Bacteria,1Q67Q@1224|Proteobacteria,2U2T5@28211|Alphaproteobacteria,2K0VU@204457|Sphingomonadales	204457|Sphingomonadales	I	enoyl-CoA hydratase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_7682088_80	1123267.JONN01000001_gene644	9.863e-33	139.0	COG4961@1|root,COG4961@2|Bacteria,1NI9M@1224|Proteobacteria,2UM62@28211|Alphaproteobacteria,2K7R9@204457|Sphingomonadales	204457|Sphingomonadales	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_7682088_81	1123267.JONN01000001_gene643	3.905e-23	106.0	COG4961@1|root,COG4961@2|Bacteria,1NJI2@1224|Proteobacteria,2UKY3@28211|Alphaproteobacteria,2K8BZ@204457|Sphingomonadales	204457|Sphingomonadales	U	TadE-like protein	-	-	-	-	-	-	-	-	-	-	-	-	TadE
HKD2_k127_7682088_52	1123267.JONN01000001_gene642	5.285e-78	278.0	COG4961@1|root,COG4961@2|Bacteria,1QV5Z@1224|Proteobacteria,2TWAQ@28211|Alphaproteobacteria,2K52P@204457|Sphingomonadales	204457|Sphingomonadales	U	Putative Flp pilus-assembly TadE/G-like	-	-	-	-	-	-	-	-	-	-	-	-	Tad
HKD2_k127_7682088_15	1123267.JONN01000001_gene641	2.3e-187	592.0	COG3853@1|root,COG3853@2|Bacteria,1MY18@1224|Proteobacteria,2TU4T@28211|Alphaproteobacteria,2K07G@204457|Sphingomonadales	204457|Sphingomonadales	P	Toxic anion resistance	-	-	-	-	-	-	-	-	-	-	-	-	TelA
HKD2_k127_7682088_63	1123267.JONN01000001_gene640	1.56e-67	237.0	2F69V@1|root,33YTJ@2|Bacteria,1MYST@1224|Proteobacteria,2UA2M@28211|Alphaproteobacteria,2K4MC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_84	485913.Krac_10552	5.895e-07	63.0	COG4585@1|root,COG4585@2|Bacteria	2|Bacteria	T	Histidine kinase	-	-	-	-	-	-	-	-	-	-	-	-	HATPase_c,HisKA_3
HKD2_k127_7682088_77	392499.Swit_0230	2.723e-41	160.0	2ENSP@1|root,33GDV@2|Bacteria,1N3J8@1224|Proteobacteria,2UBZE@28211|Alphaproteobacteria,2K5KK@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_25	1238182.C882_1850	6.324e-142	466.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	2.8.3.16	ko:K07749	-	-	-	-	ko00000,ko01000	-	-	-	CoA_transf_3
HKD2_k127_7682088_5	1123267.JONN01000001_gene636	5.318e-272	845.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2JZXX@204457|Sphingomonadales	204457|Sphingomonadales	Q	Oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_7682088_8	1123267.JONN01000001_gene635	5.65e-226	707.0	COG1249@1|root,COG1249@2|Bacteria,1MU2Z@1224|Proteobacteria,2TQS7@28211|Alphaproteobacteria,2K11W@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family	gor	-	1.8.1.7	ko:K00383	ko00480,ko04918,map00480,map04918	-	R00094,R00115	RC00011	ko00000,ko00001,ko01000	-	-	-	Pyr_redox_2,Pyr_redox_dim
HKD2_k127_7682088_71	228405.HNE_0628	1.447e-49	190.0	COG3577@1|root,COG3577@2|Bacteria	2|Bacteria	S	aspartic-type endopeptidase activity	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,PDZ_2,gag-asp_proteas
HKD2_k127_7682088_13	1123269.NX02_13330	1.353e-192	618.0	COG0166@1|root,COG0166@2|Bacteria,1MUFP@1224|Proteobacteria,2TQKP@28211|Alphaproteobacteria,2K0KU@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the GPI family	pgi	GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0044424,GO:0044464	5.3.1.9	ko:K01810	ko00010,ko00030,ko00500,ko00520,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00500,map00520,map01100,map01110,map01120,map01130,map01200	M00001,M00004,M00114	R02739,R02740,R03321	RC00376,RC00563	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	PGI
HKD2_k127_7682088_43	1123267.JONN01000001_gene633	6.059e-99	331.0	COG0681@1|root,COG0681@2|Bacteria,1MXUF@1224|Proteobacteria,2TR9N@28211|Alphaproteobacteria,2K1QM@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the peptidase S26 family	-	-	3.4.21.89	ko:K03100	ko02024,ko03060,map02024,map03060	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S24
HKD2_k127_7682088_50	1123267.JONN01000001_gene632	3.824e-81	278.0	COG0571@1|root,COG0571@2|Bacteria,1MUQ6@1224|Proteobacteria,2TTIA@28211|Alphaproteobacteria,2K1G1@204457|Sphingomonadales	204457|Sphingomonadales	J	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre- crRNA and tracrRNA of type II CRISPR loci if present in the organism	rnc	-	3.1.26.3	ko:K03685	ko03008,ko05205,map03008,map05205	-	-	-	ko00000,ko00001,ko01000,ko03009,ko03019,ko03036	-	-	-	Ribonucleas_3_3,dsrm
HKD2_k127_7682088_31	1123267.JONN01000001_gene631	4.146e-126	410.0	COG1159@1|root,COG1159@2|Bacteria,1MUKT@1224|Proteobacteria,2TSHM@28211|Alphaproteobacteria,2K01W@204457|Sphingomonadales	204457|Sphingomonadales	S	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism	era	-	-	ko:K03595	-	-	-	-	ko00000,ko03009,ko03029	-	-	-	KH_2,MMR_HSR1
HKD2_k127_7682088_37	1123267.JONN01000001_gene630	8.248e-113	368.0	COG0846@1|root,COG0846@2|Bacteria,1MUK1@1224|Proteobacteria,2TV1Q@28211|Alphaproteobacteria,2K1HB@204457|Sphingomonadales	204457|Sphingomonadales	K	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form	cobB	-	-	ko:K12410	-	-	-	-	ko00000,ko01000	-	-	-	SIR2
HKD2_k127_7682088_48	555793.WSK_3209	2.907e-84	286.0	COG1801@1|root,COG1801@2|Bacteria,1MU7F@1224|Proteobacteria,2TT1D@28211|Alphaproteobacteria,2K0SX@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function DUF72	-	-	-	-	-	-	-	-	-	-	-	-	DUF72
HKD2_k127_7682088_47	1123267.JONN01000001_gene628	9.413e-88	295.0	COG0289@1|root,COG0289@2|Bacteria,1MUCT@1224|Proteobacteria,2TSFJ@28211|Alphaproteobacteria,2K2CC@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate	dapB	-	1.17.1.8	ko:K00215	ko00261,ko00300,ko01100,ko01110,ko01120,ko01130,ko01230,map00261,map00300,map01100,map01110,map01120,map01130,map01230	M00016,M00525,M00526,M00527	R04198,R04199	RC00478	ko00000,ko00001,ko00002,ko01000	-	-	-	DapB_C,DapB_N
HKD2_k127_7682088_23	204669.Acid345_1474	1.763e-148	484.0	COG1113@1|root,COG1113@2|Bacteria	2|Bacteria	E	amino acid transport	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_7682088_45	204669.Acid345_1475	4.149e-90	311.0	COG0436@1|root,COG0436@2|Bacteria,3Y5AV@57723|Acidobacteria,2JJXH@204432|Acidobacteriia	204432|Acidobacteriia	E	Cys/Met metabolism PLP-dependent enzyme	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_7682088_41	1030157.AFMP01000052_gene268	5.655e-102	340.0	COG0177@1|root,COG0177@2|Bacteria,1MUYQ@1224|Proteobacteria,2TRI2@28211|Alphaproteobacteria,2K0EP@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate	nth	-	4.2.99.18	ko:K10773	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	EndIII_4Fe-2S,HhH-GPD
HKD2_k127_7682088_30	685778.AORL01000016_gene2284	3.549e-127	417.0	COG0787@1|root,COG0787@2|Bacteria,1MV0Q@1224|Proteobacteria,2TQKD@28211|Alphaproteobacteria,2K0BU@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids	alr	-	5.1.1.1	ko:K01775	ko00473,ko01100,ko01502,map00473,map01100,map01502	-	R00401	RC00285	ko00000,ko00001,ko01000,ko01011	-	-	-	Ala_racemase_C,Ala_racemase_N
HKD2_k127_7682088_72	1248760.ANFZ01000004_gene1994	1.461e-49	181.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2UBRG@28211|Alphaproteobacteria,2K5NY@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_7682088_40	1041142.ATTP01000002_gene3849	5.124e-109	373.0	COG1231@1|root,COG1231@2|Bacteria,1MUPQ@1224|Proteobacteria,2TRVT@28211|Alphaproteobacteria,4B8MR@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Flavin containing amine oxidoreductase	-	-	1.4.3.4	ko:K00274	ko00260,ko00330,ko00340,ko00350,ko00360,ko00380,ko00950,ko00982,ko01100,ko01110,ko04726,ko04728,ko05030,ko05031,ko05034,map00260,map00330,map00340,map00350,map00360,map00380,map00950,map00982,map01100,map01110,map04726,map04728,map05030,map05031,map05034	M00135	R02173,R02382,R02529,R02532,R02613,R02908,R02919,R04025,R04300,R04674,R04890,R04893,R04894,R04907,R04908,R08346,R08347,R08348,R11354	RC00062,RC00160,RC00225,RC00676,RC00807,RC00808,RC01808,RC02226,RC02713	ko00000,ko00001,ko00002,ko01000	-	-	-	Amino_oxidase
HKD2_k127_7682088_2	1123267.JONN01000002_gene52	1e-323	997.0	COG0449@1|root,COG0449@2|Bacteria,1MW4K@1224|Proteobacteria,2TQPM@28211|Alphaproteobacteria,2K017@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source	glmS	-	2.6.1.16	ko:K00820	ko00250,ko00520,ko01100,ko01130,ko04931,map00250,map00520,map01100,map01130,map04931	-	R00768	RC00010,RC00163,RC02752	ko00000,ko00001,ko01000,ko01002	-	-	-	GATase_6,SIS
HKD2_k127_7682088_12	1123267.JONN01000002_gene49	3.338e-196	622.0	COG1207@1|root,COG1207@2|Bacteria,1MUPH@1224|Proteobacteria,2TQPS@28211|Alphaproteobacteria,2K246@204457|Sphingomonadales	204457|Sphingomonadales	M	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain	glmU	-	2.3.1.157,2.7.7.23	ko:K04042	ko00520,ko01100,ko01130,map00520,map01100,map01130	M00362	R00416,R05332	RC00002,RC00004,RC00166	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,NTP_transf_3
HKD2_k127_7682088_68	392499.Swit_0120	1.797e-54	194.0	COG0848@1|root,COG0848@2|Bacteria,1RHDF@1224|Proteobacteria,2UEA0@28211|Alphaproteobacteria,2K55Z@204457|Sphingomonadales	204457|Sphingomonadales	U	Biopolymer transport protein	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_7682088_69	1112212.JH584235_gene3585	5.546e-54	194.0	COG0848@1|root,COG0848@2|Bacteria,1RH4U@1224|Proteobacteria,2UAMQ@28211|Alphaproteobacteria,2K4K9@204457|Sphingomonadales	204457|Sphingomonadales	U	Biopolymer	-	-	-	ko:K03559	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	ExbD
HKD2_k127_7682088_39	1123267.JONN01000001_gene891	6.632e-111	367.0	COG0811@1|root,COG0811@2|Bacteria,1NMPB@1224|Proteobacteria,2TS4F@28211|Alphaproteobacteria,2K1P2@204457|Sphingomonadales	204457|Sphingomonadales	U	MotA TolQ ExbB proton channel	exbB	-	-	ko:K03561	-	-	-	-	ko00000,ko02000	1.A.30.2.1	-	-	MotA_ExbB
HKD2_k127_7682088_75	1123267.JONN01000001_gene890	3.924e-44	168.0	COG0810@1|root,COG0810@2|Bacteria,1RCAG@1224|Proteobacteria,2U664@28211|Alphaproteobacteria,2K187@204457|Sphingomonadales	204457|Sphingomonadales	M	Periplasmic protein TonB, links inner and outer membranes	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_7682088_76	1123267.JONN01000001_gene889	2.48e-43	166.0	COG1539@1|root,COG1539@2|Bacteria,1PSIE@1224|Proteobacteria,2UD0R@28211|Alphaproteobacteria,2K4H4@204457|Sphingomonadales	204457|Sphingomonadales	H	dihydroneopterin aldolase	-	-	1.13.11.81,4.1.2.25,5.1.99.8	ko:K01633	ko00790,ko01100,map00790,map01100	M00126,M00840	R03504,R11037,R11073	RC00721,RC00943,RC01479,RC03333,RC03334	ko00000,ko00001,ko00002,ko01000	-	-	-	FolB
HKD2_k127_7682088_54	1123267.JONN01000001_gene888	9.853e-76	263.0	COG1028@1|root,COG1028@2|Bacteria,1MUUV@1224|Proteobacteria,2TR0A@28211|Alphaproteobacteria,2K33T@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)	-	-	-	-	-	-	-	-	-	-	-	-	adh_short_C2
HKD2_k127_7682088_56	745310.G432_15250	7.86e-74	260.0	COG3816@1|root,COG3816@2|Bacteria,1RD5Q@1224|Proteobacteria,2U7DA@28211|Alphaproteobacteria,2K0YC@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09986	-	-	-	-	ko00000	-	-	-	DUF1285
HKD2_k127_7682088_64	1081640.AGFU01000011_gene1284	6.193e-65	228.0	COG0494@1|root,COG0494@2|Bacteria,1RD2C@1224|Proteobacteria,2TV3Q@28211|Alphaproteobacteria,2K3ZW@204457|Sphingomonadales	204457|Sphingomonadales	L	Nudix hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_7682088_26	1335760.ASTG01000013_gene2562	5.127e-141	462.0	COG0617@1|root,COG0617@2|Bacteria,1MVCS@1224|Proteobacteria,2TRPZ@28211|Alphaproteobacteria,2K1SR@204457|Sphingomonadales	204457|Sphingomonadales	J	Polynucleotide adenylyltransferase	cca	-	2.7.7.19	ko:K00970	ko03018,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PolyA_pol,PolyA_pol_RNAbd
HKD2_k127_7682088_62	1123267.JONN01000001_gene884	1.016e-67	241.0	COG4566@1|root,COG4566@2|Bacteria,1QYNR@1224|Proteobacteria,2TXT5@28211|Alphaproteobacteria,2K3P9@204457|Sphingomonadales	204457|Sphingomonadales	T	helix_turn_helix, Lux Regulon	-	-	-	-	-	-	-	-	-	-	-	-	GerE,PAS_9
HKD2_k127_7682088_58	1122612.AUBA01000002_gene1847	6.749e-71	250.0	COG0395@1|root,COG0395@2|Bacteria,1REG1@1224|Proteobacteria,2U2QS@28211|Alphaproteobacteria,2K6HY@204457|Sphingomonadales	204457|Sphingomonadales	G	Inward rectifier potassium channel	-	-	-	-	-	-	-	-	-	-	-	-	IRK
HKD2_k127_7682088_28	1081640.AGFU01000075_gene3330	2.682e-134	439.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,2U2M4@28211|Alphaproteobacteria,2K040@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase Family 4	-	-	-	ko:K14335	-	-	-	-	ko00000,ko01000,ko01003	-	GT4	-	Glyco_transf_4,Glycos_transf_1
HKD2_k127_7682088_53	685778.AORL01000010_gene2573	5.098e-77	265.0	COG3233@1|root,COG3233@2|Bacteria,1RIED@1224|Proteobacteria,2VERK@28211|Alphaproteobacteria,2KDTE@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2334)	-	-	-	ko:K06986	-	-	-	-	ko00000	-	-	-	DUF2334
HKD2_k127_7682088_11	1030157.AFMP01000025_gene968	6.098e-197	629.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2KEG2@204457|Sphingomonadales	204457|Sphingomonadales	T	GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_4
HKD2_k127_7682088_1	1123267.JONN01000002_gene104	0.0	1098.0	COG0188@1|root,COG0188@2|Bacteria,1MURI@1224|Proteobacteria,2TQRQ@28211|Alphaproteobacteria,2K0IA@204457|Sphingomonadales	204457|Sphingomonadales	L	Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule	parC	-	-	ko:K02621	-	-	-	-	ko00000,ko01000,ko02048,ko03032,ko03036	-	-	-	DNA_gyraseA_C,DNA_topoisoIV
HKD2_k127_7682088_34	1123267.JONN01000002_gene106	2.664e-119	391.0	COG0583@1|root,COG0583@2|Bacteria,1MWY0@1224|Proteobacteria,2TU4E@28211|Alphaproteobacteria,2K07U@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_1,LysR_substrate
HKD2_k127_7682088_21	1123267.JONN01000002_gene109	1.356e-150	478.0	COG0152@1|root,COG0152@2|Bacteria,1MUR9@1224|Proteobacteria,2TR8D@28211|Alphaproteobacteria,2K0D0@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the SAICAR synthetase family	purC	-	6.3.2.6	ko:K01923	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04591	RC00064,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	SAICAR_synt
HKD2_k127_7682088_79	1449049.JONW01000011_gene2248	6.291e-34	132.0	COG2329@1|root,COG2329@2|Bacteria,1RHK9@1224|Proteobacteria,2TZMK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Antibiotic biosynthesis monooxygenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7682088_0	1123267.JONN01000002_gene21	0.0	1183.0	COG1198@1|root,COG1198@2|Bacteria,1MUUZ@1224|Proteobacteria,2TQTQ@28211|Alphaproteobacteria,2K0DV@204457|Sphingomonadales	204457|Sphingomonadales	L	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA	priA	-	-	ko:K04066	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DEAD,Helicase_C
HKD2_k127_7682088_55	1248917.ANFX01000032_gene904	1.935e-74	263.0	COG1266@1|root,COG1266@2|Bacteria,1RJQW@1224|Proteobacteria,2UB06@28211|Alphaproteobacteria,2K5HR@204457|Sphingomonadales	204457|Sphingomonadales	S	CAAX protease self-immunity	-	-	-	ko:K07052	-	-	-	-	ko00000	-	-	-	Abi
HKD2_k127_7682088_29	1449076.JOOE01000004_gene559	1.677e-133	434.0	COG0350@1|root,COG2169@1|root,COG0350@2|Bacteria,COG2169@2|Bacteria,1N2YQ@1224|Proteobacteria,2TQRX@28211|Alphaproteobacteria,2K165@204457|Sphingomonadales	204457|Sphingomonadales	FL	Metal binding domain of Ada	ada	-	2.1.1.63	ko:K10778	-	-	-	-	ko00000,ko01000,ko03000,ko03400	-	-	-	Ada_Zn_binding,DNA_binding_1,HTH_18,Methyltransf_1N
HKD2_k127_7682088_73	1537715.JQFJ01000002_gene2239	5.932e-49	179.0	2CVTP@1|root,32SY9@2|Bacteria,1N209@1224|Proteobacteria,2UC8J@28211|Alphaproteobacteria,2K5PS@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1203)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1203
HKD2_k127_7682088_74	1123267.JONN01000002_gene14	3.279e-46	171.0	COG0454@1|root,COG0456@2|Bacteria,1RHB3@1224|Proteobacteria,2UD6D@28211|Alphaproteobacteria,2KEH9@204457|Sphingomonadales	204457|Sphingomonadales	K	Acetyltransferase (GNAT) domain	-	-	-	ko:K03829	-	-	-	-	ko00000,ko01000	-	-	-	Acetyltransf_1
HKD2_k127_7682088_61	1123267.JONN01000002_gene11	6.681e-68	236.0	COG0712@1|root,COG0712@2|Bacteria,1MVRH@1224|Proteobacteria,2U5IC@28211|Alphaproteobacteria,2K4UU@204457|Sphingomonadales	204457|Sphingomonadales	C	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation	atpH	-	-	ko:K02113	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	OSCP
HKD2_k127_7682088_4	1123267.JONN01000002_gene10	1.568e-291	899.0	COG0056@1|root,COG0056@2|Bacteria,1MUG7@1224|Proteobacteria,2TQYK@28211|Alphaproteobacteria,2K08A@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit	atpA	-	3.6.3.14	ko:K02111	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_C,ATP-synt_ab_N
HKD2_k127_7682088_32	1123267.JONN01000002_gene9	6.939e-126	408.0	COG0224@1|root,COG0224@2|Bacteria,1MU28@1224|Proteobacteria,2TR11@28211|Alphaproteobacteria,2K0A5@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex	atpG	-	-	ko:K02115	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194	3.A.2.1	-	-	ATP-synt
HKD2_k127_7682088_27	1123267.JONN01000002_gene8	3.598e-140	449.0	COG0055@1|root,COG0055@2|Bacteria,1MUFU@1224|Proteobacteria,2TRGP@28211|Alphaproteobacteria,2K03H@204457|Sphingomonadales	204457|Sphingomonadales	C	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits	atpD	-	3.6.3.14	ko:K02112	ko00190,ko00195,ko01100,map00190,map00195,map01100	M00157	-	-	ko00000,ko00001,ko00002,ko00194,ko01000	3.A.2.1	-	-	ATP-synt_ab,ATP-synt_ab_N
HKD2_k127_7727281_6	1537715.JQFJ01000002_gene1044	6.663e-35	136.0	COG1846@1|root,COG1846@2|Bacteria,1MZE9@1224|Proteobacteria,2TSUB@28211|Alphaproteobacteria,2K50Q@204457|Sphingomonadales	204457|Sphingomonadales	K	helix_turn_helix multiple antibiotic resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MarR_2
HKD2_k127_7727281_1	1537715.JQFJ01000002_gene1045	2.848e-136	443.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria,2K3PS@204457|Sphingomonadales	204457|Sphingomonadales	I	Enoyl-CoA hydratase/isomerase	-	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_7727281_0	1537715.JQFJ01000002_gene1046	1.295e-174	559.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,2K3J7@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_7727281_7	1415755.JQLV01000001_gene1790	1.173e-23	110.0	COG0824@1|root,COG0824@2|Bacteria,1MZPN@1224|Proteobacteria	1224|Proteobacteria	S	Thioesterase	-	-	3.1.2.23	ko:K01075	ko00130,ko00362,ko01100,ko01110,ko01120,map00130,map00362,map01100,map01110,map01120	-	R01301	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_7727281_4	864069.MicloDRAFT_00053120	9.247e-84	288.0	COG2423@1|root,COG2423@2|Bacteria,1MWH6@1224|Proteobacteria,2TSR9@28211|Alphaproteobacteria,1JZ4K@119045|Methylobacteriaceae	28211|Alphaproteobacteria	E	Ornithine cyclodeaminase/mu-crystallin family	-	-	1.4.1.1,1.5.1.1,4.3.1.12	ko:K01750,ko:K19244,ko:K19743	ko00250,ko00310,ko00330,ko00430,ko00960,ko01100,ko01110,ko01130,ko01230,map00250,map00310,map00330,map00430,map00960,map01100,map01110,map01130,map01230	-	R00396,R00671,R01246,R01249,R02201,R02203	RC00008,RC00135,RC00354	ko00000,ko00001,ko01000	-	-	-	OCD_Mu_crystall
HKD2_k127_7727281_3	1030157.AFMP01000040_gene1526	3.386e-118	391.0	COG0520@1|root,COG0520@2|Bacteria,1QU0N@1224|Proteobacteria,2VFZ5@28211|Alphaproteobacteria,2K363@204457|Sphingomonadales	204457|Sphingomonadales	E	Aminotransferase class-V	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_7727281_5	392499.Swit_0503	7.549e-75	263.0	COG1171@1|root,COG1171@2|Bacteria,1MVWJ@1224|Proteobacteria,2TQN9@28211|Alphaproteobacteria,2K130@204457|Sphingomonadales	28211|Alphaproteobacteria	E	Threonine dehydratase	-	-	4.3.1.19	ko:K01754	ko00260,ko00290,ko01100,ko01110,ko01130,ko01200,ko01230,map00260,map00290,map01100,map01110,map01130,map01200,map01230	M00570	R00220,R00996	RC00418,RC02600	ko00000,ko00001,ko00002,ko01000	-	-	-	PALP
HKD2_k127_7727281_2	159450.NH14_15235	3.721e-128	416.0	COG1113@1|root,COG1113@2|Bacteria,1MUPS@1224|Proteobacteria,2W9H2@28216|Betaproteobacteria,1KBZG@119060|Burkholderiaceae	28216|Betaproteobacteria	E	Amino acid permease	-	-	-	-	-	-	-	-	-	-	-	-	AA_permease
HKD2_k127_7766546_5	1267005.KB911259_gene4073	2.574e-32	128.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	protein involved in response to NO	-	-	-	ko:K07234	-	-	-	-	ko00000	-	-	-	NnrS
HKD2_k127_7766546_3	670307.HYPDE_29173	3.992e-101	341.0	COG1477@1|root,COG1477@2|Bacteria,1MW6K@1224|Proteobacteria,2TRUU@28211|Alphaproteobacteria,3N8CJ@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	H	Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein	nosX	-	2.7.1.180	ko:K03734	-	-	-	-	ko00000,ko01000	-	-	-	ApbE
HKD2_k127_7766546_4	1411123.JQNH01000001_gene2735	2.02e-70	248.0	COG4314@1|root,COG4314@2|Bacteria,1RE78@1224|Proteobacteria,2U7BU@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	lipoprotein involved in nitrous oxide reduction	nosL	-	-	ko:K19342	-	-	-	-	ko00000	-	-	-	NosL
HKD2_k127_7766546_2	1411123.JQNH01000001_gene2734	5.364e-113	374.0	COG1277@1|root,COG1277@2|Bacteria,1MWUZ@1224|Proteobacteria,2U10D@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	COG1277 ABC-type transport system involved in multi-copper enzyme maturation, permease component	nosY	-	-	ko:K01992,ko:K19341	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC2_membrane_2
HKD2_k127_7766546_1	1304878.AUGD01000002_gene1551	3.225e-118	390.0	COG1131@1|root,COG1131@2|Bacteria,1MUX3@1224|Proteobacteria,2TSI2@28211|Alphaproteobacteria,3JQY0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	V	AAA domain, putative AbiEii toxin, Type IV TA system	nosF	-	-	ko:K01990,ko:K19340	ko02010,map02010	M00254,M00762	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1,3.A.1.132.2	-	-	ABC_tran
HKD2_k127_7766546_0	670307.HYPDE_29153	8.549e-131	420.0	COG3420@1|root,COG3420@2|Bacteria,1MVCD@1224|Proteobacteria,2TQTC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG3420 Nitrous oxidase accessory protein	nosD	-	-	ko:K07218	-	-	-	-	ko00000	-	-	-	NosD
HKD2_k127_7824308_38	1549858.MC45_11450	2.818e-12	69.0	2E42X@1|root,30095@2|Bacteria,1PQG3@1224|Proteobacteria,2V2V1@28211|Alphaproteobacteria,2KB7X@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7824308_17	398527.Bphyt_5641	2.286e-125	411.0	28IG1@1|root,2Z8HJ@2|Bacteria,1N0Z9@1224|Proteobacteria,2WB57@28216|Betaproteobacteria,1K49U@119060|Burkholderiaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7824308_21	1123269.NX02_12550	1.714e-92	311.0	COG0702@1|root,COG0702@2|Bacteria,1MYVU@1224|Proteobacteria,2TTHA@28211|Alphaproteobacteria,2K317@204457|Sphingomonadales	204457|Sphingomonadales	GM	NAD(P)H-binding	-	-	-	-	-	-	-	-	-	-	-	-	NmrA
HKD2_k127_7824308_26	317655.Sala_0595	2.693e-67	236.0	COG1309@1|root,COG1309@2|Bacteria,1RBV0@1224|Proteobacteria,2U7VY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	COG1309 Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	TetR_N
HKD2_k127_7824308_32	745310.G432_06135	2.698e-44	167.0	COG3169@1|root,COG3169@2|Bacteria,1RHBQ@1224|Proteobacteria,2U9M1@28211|Alphaproteobacteria,2K5R2@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative member of DMT superfamily (DUF486)	-	-	-	ko:K09922	-	-	-	-	ko00000	-	-	-	DMT_6
HKD2_k127_7824308_5	1123267.JONN01000002_gene82	5.857e-213	670.0	COG0165@1|root,COG0165@2|Bacteria,1MUTU@1224|Proteobacteria,2TR4H@28211|Alphaproteobacteria,2K185@204457|Sphingomonadales	204457|Sphingomonadales	E	argininosuccinate lyase	argH	-	4.3.2.1	ko:K01755	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,map00220,map00250,map01100,map01110,map01130,map01230	M00029,M00844,M00845	R01086	RC00445,RC00447	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	ASL_C2,Lyase_1
HKD2_k127_7824308_3	1123267.JONN01000002_gene83	1.376e-231	720.0	COG0137@1|root,COG0137@2|Bacteria,1MV0Y@1224|Proteobacteria,2TTGS@28211|Alphaproteobacteria,2K0AN@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the argininosuccinate synthase family. Type 1 subfamily	argG	-	6.3.4.5	ko:K01940	ko00220,ko00250,ko01100,ko01110,ko01130,ko01230,ko05418,map00220,map00250,map01100,map01110,map01130,map01230,map05418	M00029,M00844,M00845	R01954	RC00380,RC00629	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Arginosuc_synth
HKD2_k127_7824308_18	1123267.JONN01000002_gene84	3.325e-111	368.0	COG0078@1|root,COG0078@2|Bacteria,1MUFM@1224|Proteobacteria,2TR81@28211|Alphaproteobacteria,2K0CM@204457|Sphingomonadales	204457|Sphingomonadales	E	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline	argF	-	2.1.3.3	ko:K00611	ko00220,ko01100,ko01110,ko01130,ko01230,map00220,map01100,map01110,map01130,map01230	M00029,M00844	R01398	RC00096	ko00000,ko00001,ko00002,ko01000	-	-	-	OTCace,OTCace_N
HKD2_k127_7824308_22	1161401.ASJA01000022_gene124	2.147e-85	293.0	COG0548@1|root,COG0548@2|Bacteria,1MU17@1224|Proteobacteria,2TQQS@28211|Alphaproteobacteria,43W4H@69657|Hyphomonadaceae	28211|Alphaproteobacteria	E	Belongs to the acetylglutamate kinase family. ArgB subfamily	argB	-	2.3.1.1,2.7.2.8	ko:K00930,ko:K22478	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R00259,R02649	RC00002,RC00004,RC00043,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	AA_kinase,NAT
HKD2_k127_7824308_9	1123267.JONN01000002_gene86	7.694e-168	535.0	COG1364@1|root,COG1364@2|Bacteria,1MU0T@1224|Proteobacteria,2TS98@28211|Alphaproteobacteria,2K035@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate	argJ	-	2.3.1.1,2.3.1.35	ko:K00620	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028	R00259,R02282	RC00004,RC00064	ko00000,ko00001,ko00002,ko01000	-	-	-	ArgJ
HKD2_k127_7824308_13	1123267.JONN01000002_gene87	1.722e-140	453.0	COG0002@1|root,COG0002@2|Bacteria,1MVJ6@1224|Proteobacteria,2TRMT@28211|Alphaproteobacteria,2K2G3@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde	argC	-	1.2.1.38	ko:K00145	ko00220,ko01100,ko01110,ko01130,ko01210,ko01230,map00220,map01100,map01110,map01130,map01210,map01230	M00028,M00845	R03443	RC00684	ko00000,ko00001,ko00002,ko01000	-	-	-	Semialdhyde_dh
HKD2_k127_7824308_33	1123267.JONN01000002_gene88	1.599e-41	158.0	COG1438@1|root,COG1438@2|Bacteria,1NKFW@1224|Proteobacteria,2UMPP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Arginine repressor, DNA binding domain	argR	-	-	ko:K03402	-	-	-	-	ko00000,ko03000	-	-	-	Arg_repressor,Arg_repressor_C
HKD2_k127_7824308_27	1502850.FG91_03201	1.33e-65	226.0	2DEWU@1|root,2ZPJP@2|Bacteria,1NBPN@1224|Proteobacteria,2VGJK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7824308_19	314266.SKA58_04080	2.369e-104	345.0	COG0491@1|root,COG0491@2|Bacteria,1MURA@1224|Proteobacteria,2TR1F@28211|Alphaproteobacteria,2K3NJ@204457|Sphingomonadales	204457|Sphingomonadales	P	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B,Rhodanese
HKD2_k127_7824308_7	1123267.JONN01000001_gene1930	4.306e-185	587.0	COG0179@1|root,COG0179@2|Bacteria,1MW82@1224|Proteobacteria,2TRKH@28211|Alphaproteobacteria,2K0SS@204457|Sphingomonadales	204457|Sphingomonadales	Q	Fumarylacetoacetase	-	-	3.7.1.2	ko:K01555	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R01364	RC00326,RC00446	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	FAA_hydrolase,FAA_hydrolase_N
HKD2_k127_7824308_4	1007104.SUS17_1311	8.311e-219	684.0	COG3508@1|root,COG3508@2|Bacteria,1MV9G@1224|Proteobacteria,2TRFI@28211|Alphaproteobacteria,2K0UM@204457|Sphingomonadales	204457|Sphingomonadales	Q	Involved in the catabolism of homogentisate (2,5- dihydroxyphenylacetate or 2,5-OH-PhAc), a central intermediate in the degradation of phenylalanine and tyrosine. Catalyzes the oxidative ring cleavage of the aromatic ring of homogentisate to yield maleylacetoacetate	hmgA	-	1.13.11.5	ko:K00451	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R02519	RC00737	ko00000,ko00001,ko00002,ko01000	-	-	-	HgmA
HKD2_k127_7824308_36	1522072.IL54_0346	1.244e-20	100.0	COG3895@1|root,COG3895@2|Bacteria,1N8G9@1224|Proteobacteria,2UQIF@28211|Alphaproteobacteria,2K4MY@204457|Sphingomonadales	204457|Sphingomonadales	S	Periplasmic Protein	-	-	-	-	-	-	-	-	-	-	-	-	MliC
HKD2_k127_7824308_37	1304878.AUGD01000009_gene6263	1.426e-16	81.0	2EGHB@1|root,33A9F@2|Bacteria,1N1DH@1224|Proteobacteria,2UEKD@28211|Alphaproteobacteria,3K0Q5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	KTSC domain	-	-	-	-	-	-	-	-	-	-	-	-	KTSC
HKD2_k127_7824308_20	1123267.JONN01000001_gene1869	5.135e-100	335.0	COG0697@1|root,COG0697@2|Bacteria,1MXJY@1224|Proteobacteria,2TVBG@28211|Alphaproteobacteria,2K0J7@204457|Sphingomonadales	204457|Sphingomonadales	EG	Permeases of the drug metabolite transporter (DMT) superfamily	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_7824308_12	1123267.JONN01000001_gene1868	1.699e-142	458.0	COG2008@1|root,COG2008@2|Bacteria,1MWCR@1224|Proteobacteria,2TSUA@28211|Alphaproteobacteria,2K0EJ@204457|Sphingomonadales	204457|Sphingomonadales	E	Threonine aldolase	ltaA	-	4.1.2.48	ko:K01620	ko00260,ko01100,ko01110,ko01120,ko01130,ko01230,map00260,map01100,map01110,map01120,map01130,map01230	-	R00751,R06171	RC00312,RC00372	ko00000,ko00001,ko01000	-	-	-	Beta_elim_lyase
HKD2_k127_7824308_31	291985.CCSI01000002_gene1706	2.426e-45	170.0	COG1917@1|root,COG1917@2|Bacteria,1RHWW@1224|Proteobacteria,2U97R@28211|Alphaproteobacteria,2KE5X@204457|Sphingomonadales	204457|Sphingomonadales	S	Cupin 2, conserved barrel domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_7824308_2	1123267.JONN01000001_gene1864	1.027e-295	918.0	COG0006@1|root,COG0006@2|Bacteria,1MUZS@1224|Proteobacteria,2TQXN@28211|Alphaproteobacteria,2K0TU@204457|Sphingomonadales	204457|Sphingomonadales	E	aminopeptidase	-	-	3.4.11.9	ko:K01262	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Creatinase_N,Creatinase_N_2,Peptidase_M24,Peptidase_M24_C
HKD2_k127_7824308_1	1123267.JONN01000001_gene1863	0.0	1009.0	COG1770@1|root,COG1770@2|Bacteria,1MUED@1224|Proteobacteria,2TTR0@28211|Alphaproteobacteria,2K19E@204457|Sphingomonadales	204457|Sphingomonadales	E	peptidase S9	ptrB	-	3.4.21.83	ko:K01354	ko05142,ko05143,map05142,map05143	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	Peptidase_S9,Peptidase_S9_N
HKD2_k127_7824308_28	1123267.JONN01000001_gene1861	4.425e-54	193.0	COG0824@1|root,COG0824@2|Bacteria,1N06V@1224|Proteobacteria,2UCAQ@28211|Alphaproteobacteria,2K5A4@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	Acyl-ACP_TE
HKD2_k127_7824308_24	1123267.JONN01000001_gene1860	1.361e-75	259.0	COG0625@1|root,COG0625@2|Bacteria,1RA4Y@1224|Proteobacteria,2U5B6@28211|Alphaproteobacteria,2K49D@204457|Sphingomonadales	204457|Sphingomonadales	O	maleylacetoacetate isomerase	-	-	5.2.1.2,5.2.1.4	ko:K01800,ko:K01801	ko00350,ko00643,ko01100,ko01120,map00350,map00643,map01100,map01120	M00044	R03181,R03868	RC00867	ko00000,ko00001,ko00002,ko01000	-	-	-	GST_C_2,GST_N,GST_N_3
HKD2_k127_7824308_14	1123267.JONN01000001_gene1859	2.863e-139	448.0	COG0235@1|root,COG0235@2|Bacteria,1MWP9@1224|Proteobacteria,2TRMV@28211|Alphaproteobacteria,2K1HY@204457|Sphingomonadales	204457|Sphingomonadales	G	Aldolase	-	-	-	-	-	-	-	-	-	-	-	-	Aldolase_II
HKD2_k127_7824308_34	1120919.AUBI01000011_gene2334	2.091e-36	143.0	COG2128@1|root,COG2128@2|Bacteria,1RD1K@1224|Proteobacteria,2U6ZZ@28211|Alphaproteobacteria,2JU9D@204441|Rhodospirillales	204441|Rhodospirillales	S	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity	-	-	-	-	-	-	-	-	-	-	-	-	CMD
HKD2_k127_7824308_15	582402.Hbal_2679	1.911e-136	444.0	COG1304@1|root,COG1304@2|Bacteria,1MUEZ@1224|Proteobacteria,2TQNW@28211|Alphaproteobacteria,43Z5M@69657|Hyphomonadaceae	28211|Alphaproteobacteria	C	FMN-dependent dehydrogenase	lldD	-	1.1.2.3	ko:K00101	ko00620,ko01100,map00620,map01100	-	R00196	RC00044	ko00000,ko00001,ko01000	-	-	-	FMN_dh
HKD2_k127_7824308_6	1112216.JH594425_gene2643	1.749e-203	658.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2K0SK@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,HAMP,dCache_3
HKD2_k127_7824308_30	1382303.JPOM01000001_gene2380	4.052e-50	187.0	COG3794@1|root,COG3794@2|Bacteria,1RHQU@1224|Proteobacteria,2UBHY@28211|Alphaproteobacteria,2KGRB@204458|Caulobacterales	204458|Caulobacterales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7824308_23	1449076.JOOE01000001_gene3026	1.425e-78	278.0	2C8CD@1|root,2Z9AD@2|Bacteria,1N17D@1224|Proteobacteria,2URI7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7824308_42	891974.E05_32090	0.0003443	44.0	28Z00@1|root,2ZKSP@2|Bacteria,1P60B@1224|Proteobacteria,1SVSK@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7824308_8	1123267.JONN01000001_gene1978	1.998e-182	580.0	COG0493@1|root,COG0493@2|Bacteria,1P58U@1224|Proteobacteria,2TUCG@28211|Alphaproteobacteria,2K06F@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases	-	-	1.18.1.2,1.19.1.1	ko:K00528	-	-	R10159	-	ko00000,ko01000	-	-	-	Pyr_redox_2
HKD2_k127_7824308_35	1123267.JONN01000001_gene1979	1.983e-26	113.0	2E9WT@1|root,3342I@2|Bacteria,1NBEH@1224|Proteobacteria,2UFGC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn)	MA20_00895	-	-	-	-	-	-	-	-	-	-	-	PHA_gran_rgn
HKD2_k127_7824308_25	1123267.JONN01000001_gene1980	1.111e-72	253.0	COG3108@1|root,COG3108@2|Bacteria,1N3XU@1224|Proteobacteria,2V6WT@28211|Alphaproteobacteria,2KAR6@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase M15	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M15_3
HKD2_k127_7824308_0	1123267.JONN01000001_gene1981	0.0	1446.0	COG0542@1|root,COG0542@2|Bacteria,1MURH@1224|Proteobacteria,2TRKI@28211|Alphaproteobacteria,2K00X@204457|Sphingomonadales	204457|Sphingomonadales	O	Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE	clpB	-	-	ko:K03695	ko04213,map04213	-	-	-	ko00000,ko00001,ko03110	-	-	-	AAA,AAA_2,ClpB_D2-small,Clp_N
HKD2_k127_7824308_16	392499.Swit_3142	4.433e-132	439.0	COG0457@1|root,COG0457@2|Bacteria,1RHFI@1224|Proteobacteria,2TXPR@28211|Alphaproteobacteria,2KEIN@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative 2OG-Fe(II) oxygenase	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy_5
HKD2_k127_7824308_11	1123267.JONN01000001_gene1983	2.285e-146	472.0	COG3555@1|root,COG3555@2|Bacteria,1MXZE@1224|Proteobacteria,2UQPG@28211|Alphaproteobacteria,2KD8E@204457|Sphingomonadales	204457|Sphingomonadales	O	Aspartyl/Asparaginyl beta-hydroxylase	-	-	-	-	-	-	-	-	-	-	-	-	Asp_Arg_Hydrox
HKD2_k127_7824308_10	194867.ALBQ01000009_gene2338	2.85e-160	527.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K26Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_8
HKD2_k127_7824308_29	1123267.JONN01000001_gene1984	4.574e-51	184.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K26Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_1,TPR_16,TPR_19,TPR_8
HKD2_k127_78620_6	443598.AUFA01000001_gene1531	2.542e-11	65.0	COG0616@1|root,COG0616@2|Bacteria,1MUXE@1224|Proteobacteria,2TSXA@28211|Alphaproteobacteria,3JSKK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	OU	signal peptide peptidase SppA	sppA	-	-	ko:K04773	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_S49
HKD2_k127_78620_0	1187851.A33M_1236	1.143e-314	974.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,3FCS0@34008|Rhodovulum	28211|Alphaproteobacteria	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_78620_2	709797.CSIRO_0839	2.054e-84	286.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,3JRP0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	GO:0003674,GO:0003824,GO:0004127,GO:0004592,GO:0005575,GO:0005622,GO:0005623,GO:0005737,GO:0005829,GO:0006082,GO:0006139,GO:0006520,GO:0006573,GO:0006575,GO:0006725,GO:0006732,GO:0006753,GO:0006766,GO:0006767,GO:0006793,GO:0006796,GO:0006807,GO:0008150,GO:0008152,GO:0009058,GO:0009081,GO:0009108,GO:0009110,GO:0009117,GO:0009123,GO:0009165,GO:0009987,GO:0015939,GO:0015940,GO:0016053,GO:0016301,GO:0016310,GO:0016740,GO:0016772,GO:0016776,GO:0016874,GO:0016879,GO:0016881,GO:0018130,GO:0019205,GO:0019438,GO:0019637,GO:0019752,GO:0032787,GO:0033317,GO:0034641,GO:0034654,GO:0042364,GO:0042398,GO:0043436,GO:0043603,GO:0043604,GO:0044237,GO:0044238,GO:0044249,GO:0044271,GO:0044281,GO:0044283,GO:0044424,GO:0044444,GO:0044464,GO:0046394,GO:0046483,GO:0046939,GO:0046940,GO:0050145,GO:0051186,GO:0051188,GO:0055086,GO:0071704,GO:0072330,GO:0090407,GO:1901293,GO:1901360,GO:1901362,GO:1901564,GO:1901566,GO:1901576,GO:1901605	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_78620_1	335659.S23_00950	1.162e-202	638.0	COG0128@1|root,COG0128@2|Bacteria,1MWMK@1224|Proteobacteria,2TR6W@28211|Alphaproteobacteria,3JTQ0@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3- phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate	aroA	GO:0003674,GO:0003824,GO:0003866,GO:0006082,GO:0008150,GO:0008152,GO:0009058,GO:0009423,GO:0009987,GO:0016053,GO:0016740,GO:0016765,GO:0019752,GO:0043436,GO:0043648,GO:0043650,GO:0044237,GO:0044249,GO:0044281,GO:0044283,GO:0046394,GO:0046417,GO:0071704,GO:1901576	2.5.1.19	ko:K00800	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03460	RC00350	ko00000,ko00001,ko00002,ko01000	-	-	-	EPSP_synthase
HKD2_k127_78620_4	316058.RPB_0644	5.881e-28	118.0	COG4530@1|root,COG4530@2|Bacteria,1N85Z@1224|Proteobacteria,2UF7V@28211|Alphaproteobacteria,3JYU7@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function (FYDLN_acid)	MA20_24185	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
HKD2_k127_78620_5	189753.AXAS01000026_gene8314	2.307e-14	75.0	COG2827@1|root,COG2827@2|Bacteria,1N04N@1224|Proteobacteria,2UCN4@28211|Alphaproteobacteria,3K0D8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	GIY-YIG catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	GIY-YIG
HKD2_k127_78620_3	1415756.JQMY01000001_gene735	1.488e-51	186.0	COG2159@1|root,COG2159@2|Bacteria,1MXI7@1224|Proteobacteria,2U15G@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	metal-dependent hydrolase of the TIM-barrel fold	-	-	4.1.1.103,4.1.1.46	ko:K07045,ko:K14333,ko:K15063,ko:K20941	ko00362,ko00627,ko01120,map00362,map00627,map01120	-	R00821,R09278,R11353	RC00390,RC00569	ko00000,ko00001,ko01000	-	-	-	Amidohydro_2
HKD2_k127_7883842_0	717785.HYPMC_3257	1.853e-195	617.0	COG3039@1|root,COG3039@2|Bacteria,1MUVI@1224|Proteobacteria,2TSA7@28211|Alphaproteobacteria,3N8ZI@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	L	Transposase DDE domain	-	-	-	-	-	-	-	-	-	-	-	-	DDE_Tnp_1_6,DUF772
HKD2_k127_7883842_1	420324.KI912061_gene6270	6.042e-27	115.0	COG5002@1|root,COG5002@2|Bacteria,1RI2X@1224|Proteobacteria,2TWRF@28211|Alphaproteobacteria	28211|Alphaproteobacteria	T	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)	-	-	-	-	-	-	-	-	-	-	-	-	PAS,PAS_4
HKD2_k127_7951765_4	13689.BV96_04645	2.22e-130	428.0	COG3213@1|root,COG3213@2|Bacteria,1MUJK@1224|Proteobacteria,2TSQ2@28211|Alphaproteobacteria,2K1GY@204457|Sphingomonadales	204457|Sphingomonadales	P	NnrS protein	-	-	-	-	-	-	-	-	-	-	-	-	NnrS
HKD2_k127_7951765_22	1112212.JH584235_gene1551	2.196e-19	91.0	2EJQP@1|root,33DFH@2|Bacteria,1NI6C@1224|Proteobacteria,2UMF9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	C	Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria	-	-	-	-	-	-	-	-	-	-	-	-	HIPIP
HKD2_k127_7951765_3	1449076.JOOE01000001_gene2160	5.561e-137	447.0	COG2132@1|root,COG2132@2|Bacteria,1MV74@1224|Proteobacteria,2U1BK@28211|Alphaproteobacteria,2KAXU@204457|Sphingomonadales	204457|Sphingomonadales	Q	Nitrite reductase	-	-	-	-	-	-	-	-	-	-	-	-	Cu-oxidase
HKD2_k127_7951765_26	1120966.AUBU01000010_gene2857	6.961e-08	61.0	COG4319@1|root,COG4319@2|Bacteria,4NT0G@976|Bacteroidetes,47T3M@768503|Cytophagia	976|Bacteroidetes	S	Domain of unknown function (DUF4440)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
HKD2_k127_7951765_2	571166.KI421509_gene586	3.504e-158	509.0	COG0659@1|root,COG0659@2|Bacteria,1MVWV@1224|Proteobacteria,2TUH6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	P	COG0659 Sulfate permease and related transporters (MFS superfamily	-	-	-	ko:K03321	-	-	-	-	ko00000,ko02000	2.A.53.3	-	-	STAS,Sulfate_transp
HKD2_k127_7951765_6	1090320.KB900605_gene1578	1.662e-108	359.0	COG0142@1|root,COG0142@2|Bacteria,1MWNG@1224|Proteobacteria,2TR79@28211|Alphaproteobacteria,2K19H@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the FPP GGPP synthase family	ispA	-	2.5.1.1,2.5.1.10	ko:K00795	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00364	R01658,R02003	RC00279	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	polyprenyl_synt
HKD2_k127_7951765_9	622637.KE124774_gene2001	7.398e-86	297.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,36X3C@31993|Methylocystaceae	28211|Alphaproteobacteria	IM	LytB protein	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD2_k127_7951765_17	627192.SLG_31690	5.406e-41	156.0	COG4704@1|root,COG4704@2|Bacteria,1N6RE@1224|Proteobacteria,2UEB7@28211|Alphaproteobacteria,2K5WY@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2141
HKD2_k127_7951765_7	1090319.KE386571_gene2780	3.255e-108	364.0	COG0654@1|root,COG0654@2|Bacteria,1N8DE@1224|Proteobacteria,2TU88@28211|Alphaproteobacteria,2K0B6@204457|Sphingomonadales	204457|Sphingomonadales	CH	Lycopene cyclase protein	crtY	-	5.5.1.19	ko:K06443	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00097	R03824,R04801,R05341,R06962,R07856	RC01004,RC01964	ko00000,ko00001,ko00002,ko01000	-	-	-	Lycopene_cycl
HKD2_k127_7951765_0	1123269.NX02_00970	2.888e-224	717.0	COG1233@1|root,COG1233@2|Bacteria,1MV2R@1224|Proteobacteria,2TSR0@28211|Alphaproteobacteria,2K17H@204457|Sphingomonadales	204457|Sphingomonadales	Q	Phytoene dehydrogenase	crtI	-	1.3.99.26,1.3.99.28,1.3.99.29,1.3.99.31	ko:K10027	ko00906,ko01100,ko01110,map00906,map01100,map01110	-	R04787,R04798,R04800,R09691,R09692	RC01214,RC02088,RC02605	ko00000,ko00001,ko01000	-	-	-	Amino_oxidase
HKD2_k127_7951765_8	1123270.ATUR01000004_gene1561	7.093e-87	297.0	COG1562@1|root,COG1562@2|Bacteria,1MX4W@1224|Proteobacteria,2TTI0@28211|Alphaproteobacteria,2K2BH@204457|Sphingomonadales	204457|Sphingomonadales	I	Phytoene synthase	crtB	-	2.5.1.32,2.5.1.99	ko:K02291	ko00906,ko01062,ko01100,ko01110,map00906,map01062,map01100,map01110	M00097	R02065,R04218,R07270,R10177	RC00362,RC01101,RC02869	ko00000,ko00001,ko00002,ko01000,ko01006	-	-	-	SQS_PSY
HKD2_k127_7951765_5	1346791.M529_19415	1.005e-114	374.0	COG3000@1|root,COG3000@2|Bacteria,1NXAF@1224|Proteobacteria,2TRF0@28211|Alphaproteobacteria,2K0X1@204457|Sphingomonadales	204457|Sphingomonadales	I	sterol desaturase	-	-	-	-	-	-	-	-	-	-	-	-	FA_hydroxylase
HKD2_k127_7951765_10	1123269.NX02_21750	1.467e-70	241.0	COG3000@1|root,COG3000@2|Bacteria,1MYGK@1224|Proteobacteria,2UAP4@28211|Alphaproteobacteria,2KCDZ@204457|Sphingomonadales	204457|Sphingomonadales	I	Fatty acid hydroxylase superfamily	crtZ	-	1.14.15.24	ko:K15746	ko00906,ko01100,ko01110,map00906,map01100,map01110	M00372	R07530,R07558,R07559,R07561,R07562,R07568,R07569,R07570,R07572,R07851,R09747	RC00478,RC00704,RC02629	ko00000,ko00001,ko00002,ko01000	-	-	-	FA_hydroxylase
HKD2_k127_7951765_12	1550073.JROH01000054_gene3282	3.845e-54	201.0	COG3449@1|root,COG3449@2|Bacteria,1RF2U@1224|Proteobacteria,2UBIJ@28211|Alphaproteobacteria,2K5PR@204457|Sphingomonadales	204457|Sphingomonadales	L	SOUL heme-binding protein	-	-	-	-	-	-	-	-	-	-	-	-	SOUL
HKD2_k127_7951765_25	622637.KE124774_gene2881	3.617e-10	63.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,36XJX@31993|Methylocystaceae	28211|Alphaproteobacteria	V	AcrB/AcrD/AcrF family	-	-	-	-	-	-	-	-	-	-	-	-	ACR_tran
HKD2_k127_7951765_18	1200792.AKYF01000006_gene1477	5.251e-38	147.0	COG0662@1|root,COG0662@2|Bacteria,1V9DQ@1239|Firmicutes,4HJK4@91061|Bacilli,26YM0@186822|Paenibacillaceae	91061|Bacilli	G	Cupin domain	algA	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_7951765_13	1245469.S58_65480	1.752e-48	176.0	COG1917@1|root,COG1917@2|Bacteria,1RGXQ@1224|Proteobacteria,2U7IF@28211|Alphaproteobacteria,3JYR5@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Cupin 2, conserved barrel domain protein	MA20_27600	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7951765_24	1237149.C900_01128	1.038e-14	78.0	COG0693@1|root,COG0693@2|Bacteria	2|Bacteria	S	protein deglycation	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_7951765_23	762376.AXYL_04753	9.542e-15	82.0	COG0693@1|root,COG0693@2|Bacteria,1MYS4@1224|Proteobacteria,2VHFV@28216|Betaproteobacteria,3T6RK@506|Alcaligenaceae	28216|Betaproteobacteria	S	DJ-1/PfpI family	-	-	-	-	-	-	-	-	-	-	-	-	DJ-1_PfpI
HKD2_k127_7951765_16	1192759.AKIB01000052_gene902	8.855e-45	165.0	COG5489@1|root,COG5489@2|Bacteria,1RHTI@1224|Proteobacteria,2UAD0@28211|Alphaproteobacteria,2K5F8@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF736)	-	-	-	-	-	-	-	-	-	-	-	-	DUF736
HKD2_k127_7951765_1	1331060.RLDS_11560	1.459e-213	681.0	COG3843@1|root,COG3843@2|Bacteria,1MU0S@1224|Proteobacteria,2TSP8@28211|Alphaproteobacteria,2K23N@204457|Sphingomonadales	204457|Sphingomonadales	U	Type IV secretory pathway VirD2	traI	-	-	-	-	-	-	-	-	-	-	-	DUF3363
HKD2_k127_7951765_14	555793.WSK_3459	2.5e-46	171.0	COG4962@1|root,COG4962@2|Bacteria,1MYR0@1224|Proteobacteria,2U9YR@28211|Alphaproteobacteria,2K4U2@204457|Sphingomonadales	204457|Sphingomonadales	U	Type ii secretion system protein e	-	-	-	-	-	-	-	-	-	-	-	-	RHH_1
HKD2_k127_7951765_20	1267533.KB906738_gene2207	1.262e-27	121.0	COG2885@1|root,COG2885@2|Bacteria,3Y7Y8@57723|Acidobacteria,2JMX3@204432|Acidobacteriia	204432|Acidobacteriia	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_7951765_15	1234595.C725_0982	5.751e-46	179.0	COG3137@1|root,COG3137@2|Bacteria,1MWI4@1224|Proteobacteria,2UBFT@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	salt-induced outer membrane protein	-	-	-	ko:K07283	-	-	-	-	ko00000	-	-	-	DUF481
HKD2_k127_7951765_11	1449049.JONW01000005_gene1177	2.461e-65	233.0	COG3900@1|root,COG3900@2|Bacteria,1RKQP@1224|Proteobacteria,2VEWI@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	periplasmic protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF2092
HKD2_k127_7951765_19	1300345.LF41_2916	6.293e-30	129.0	2C3WA@1|root,2Z8P1@2|Bacteria,1R8VC@1224|Proteobacteria,1S5UD@1236|Gammaproteobacteria	1236|Gammaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_7952196_8	1123267.JONN01000001_gene1597	7.158e-92	303.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,2K0HU@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2
HKD2_k127_7952196_17	661478.OP10G_0131	1.164e-06	53.0	COG1961@1|root,COG1961@2|Bacteria	2|Bacteria	L	recombinase activity	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_7952196_1	1382303.JPOM01000001_gene814	4.969e-263	833.0	COG2936@1|root,COG2936@2|Bacteria,1MVA8@1224|Proteobacteria,2U29S@28211|Alphaproteobacteria,2KFGJ@204458|Caulobacterales	204458|Caulobacterales	S	X-Pro dipeptidyl-peptidase domain protein	-	-	-	-	-	-	-	-	-	-	-	-	PepX_C,Peptidase_S15
HKD2_k127_7952196_11	1458357.BG58_30865	1.503e-51	193.0	COG3038@1|root,COG3038@2|Bacteria,1RDR3@1224|Proteobacteria,2W38S@28216|Betaproteobacteria	28216|Betaproteobacteria	C	Cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HKD2_k127_7952196_16	273526.SMDB11_3588	1.441e-13	82.0	COG0265@1|root,COG0265@2|Bacteria,1MU63@1224|Proteobacteria,1RN9T@1236|Gammaproteobacteria,40060@613|Serratia	1236|Gammaproteobacteria	M	Belongs to the peptidase S1C family	degQ	GO:0003674,GO:0003824,GO:0004175,GO:0004252,GO:0005488,GO:0005515,GO:0005575,GO:0005623,GO:0005886,GO:0005887,GO:0006508,GO:0006807,GO:0008150,GO:0008152,GO:0008233,GO:0008236,GO:0009056,GO:0009057,GO:0009897,GO:0009986,GO:0009987,GO:0016020,GO:0016021,GO:0016787,GO:0017171,GO:0019538,GO:0030163,GO:0031224,GO:0031226,GO:0031233,GO:0042597,GO:0042802,GO:0043170,GO:0044237,GO:0044238,GO:0044248,GO:0044257,GO:0044260,GO:0044265,GO:0044267,GO:0044425,GO:0044459,GO:0044464,GO:0051603,GO:0070011,GO:0071575,GO:0071704,GO:0071944,GO:0098552,GO:0140096,GO:1901564,GO:1901565,GO:1901575	1.3.1.74,3.4.21.107	ko:K04771,ko:K04772,ko:K08070	ko01503,ko02020,map01503,map02020	M00728	-	-	ko00000,ko00001,ko00002,ko01000,ko01002,ko03110	-	-	-	PDZ,PDZ_2,Trypsin_2
HKD2_k127_7952196_2	392499.Swit_3739	7.457e-193	617.0	COG0038@1|root,COG0517@1|root,COG0038@2|Bacteria,COG0517@2|Bacteria,1MV4K@1224|Proteobacteria,2TTBG@28211|Alphaproteobacteria,2K15J@204457|Sphingomonadales	204457|Sphingomonadales	P	Chloride channel	-	-	-	ko:K03281	-	-	-	-	ko00000	2.A.49	-	-	CBS,Voltage_CLC
HKD2_k127_7952196_7	685778.AORL01000025_gene53	5.199e-98	330.0	COG1118@1|root,COG1118@2|Bacteria,1QTTT@1224|Proteobacteria,2TVZ3@28211|Alphaproteobacteria,2KENV@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system	cysA	-	3.6.3.25	ko:K02045	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	ABC_tran
HKD2_k127_7952196_5	1219049.SP5_005_00530	1.51e-116	381.0	COG4208@1|root,COG4208@2|Bacteria,1MV8X@1224|Proteobacteria,2TQR8@28211|Alphaproteobacteria,2K2FM@204457|Sphingomonadales	204457|Sphingomonadales	P	ABC transporter	cysW	-	-	ko:K02047	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD2_k127_7952196_6	1219035.NT2_01_02070	1.889e-102	346.0	COG0555@1|root,COG0555@2|Bacteria,1QTTU@1224|Proteobacteria,2TTET@28211|Alphaproteobacteria,2K3QK@204457|Sphingomonadales	204457|Sphingomonadales	O	Binding-protein-dependent transport system inner membrane component	cysT	-	-	ko:K02046	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	BPD_transp_1
HKD2_k127_7952196_3	1366050.N234_13080	6.155e-141	456.0	COG1613@1|root,COG1613@2|Bacteria,1MUAU@1224|Proteobacteria,2VIQZ@28216|Betaproteobacteria,1K1GN@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfate ABC transporter, periplasmic sulfate-binding protein	sbp	-	-	ko:K02048	ko00920,ko02010,map00920,map02010	M00185	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.6.1,3.A.1.6.3	-	-	SBP_bac_11
HKD2_k127_7952196_13	1449076.JOOE01000001_gene3023	1.446e-38	155.0	2FDTI@1|root,345U8@2|Bacteria,1NJ6F@1224|Proteobacteria,2V4SS@28211|Alphaproteobacteria,2K6Q3@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial protein of unknown function (Gcw_chp)	-	-	-	-	-	-	-	-	-	-	-	-	Gcw_chp
HKD2_k127_7952196_4	685778.AORL01000021_gene923	2.313e-130	428.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2TT0E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	Peptidase S8 and S53 subtilisin kexin sedolisin	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_7952196_14	685778.AORL01000021_gene922	3.155e-38	151.0	2ES5B@1|root,33JQ4@2|Bacteria,1NHPR@1224|Proteobacteria,2UN83@28211|Alphaproteobacteria,2K67H@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative zinc-finger	-	-	-	-	-	-	-	-	-	-	-	-	zf-HC2
HKD2_k127_7952196_10	685778.AORL01000021_gene921	2.417e-62	220.0	COG1595@1|root,COG1595@2|Bacteria,1MVPD@1224|Proteobacteria,2TVKC@28211|Alphaproteobacteria,2K4M1@204457|Sphingomonadales	204457|Sphingomonadales	K	Sigma-70, region 4	-	-	-	-	-	-	-	-	-	-	-	-	Sigma70_r2,Sigma70_r4_2
HKD2_k127_7952196_0	1123267.JONN01000001_gene1597	1.033e-295	917.0	COG0318@1|root,COG0318@2|Bacteria,1MU6G@1224|Proteobacteria,2TW3C@28211|Alphaproteobacteria,2K0HU@204457|Sphingomonadales	204457|Sphingomonadales	IQ	COG0318 Acyl-CoA synthetases (AMP-forming) AMP-acid ligases II	-	-	-	ko:K00666	-	-	-	-	ko00000,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C_2
HKD2_k127_7952196_12	1248760.ANFZ01000002_gene3085	6.759e-39	159.0	COG2137@1|root,COG2137@2|Bacteria,1N2EE@1224|Proteobacteria,2U96W@28211|Alphaproteobacteria,2K59F@204457|Sphingomonadales	204457|Sphingomonadales	S	Regulatory protein RecX	recX	-	-	ko:K03565	-	-	-	-	ko00000,ko03400	-	-	-	RecX
HKD2_k127_7952196_9	1123267.JONN01000001_gene1595	3.76e-63	222.0	COG1278@1|root,COG1278@2|Bacteria,1RAUE@1224|Proteobacteria,2U0S7@28211|Alphaproteobacteria,2K4T8@204457|Sphingomonadales	204457|Sphingomonadales	K	Cold shock protein domain	-	-	-	ko:K03704	-	-	-	-	ko00000,ko03000	-	-	-	CSD
HKD2_k127_7952196_15	1219035.NT2_12_00180	1.708e-31	135.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,2K5JY@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_8206479_1	402881.Plav_1948	3.471e-66	233.0	COG0625@1|root,COG0625@2|Bacteria,1RD7K@1224|Proteobacteria,2TVIB@28211|Alphaproteobacteria,1JNWS@119043|Rhodobiaceae	28211|Alphaproteobacteria	O	Glutathione S-transferase, N-terminal domain	ligE	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_C_2,GST_N_3
HKD2_k127_8206479_0	1112212.JH584235_gene628	0.0	1047.0	COG1629@1|root,COG4206@1|root,COG1629@2|Bacteria,COG4206@2|Bacteria,1QU0Y@1224|Proteobacteria,2TW37@28211|Alphaproteobacteria,2KE9Q@204457|Sphingomonadales	204457|Sphingomonadales	HP	TonB dependent receptor	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_8206479_2	113395.AXAI01000036_gene338	2.816e-64	223.0	COG3059@1|root,COG3059@2|Bacteria,1RBVI@1224|Proteobacteria,2U6V1@28211|Alphaproteobacteria,3JXC2@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Protein of unknown function, DUF417	-	-	-	-	-	-	-	-	-	-	-	-	DUF417
HKD2_k127_8206479_4	1479239.JQMU01000001_gene2654	4.275e-09	66.0	COG1846@1|root,COG1846@2|Bacteria,1NYW3@1224|Proteobacteria,2UTVX@28211|Alphaproteobacteria,2K6HH@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
HKD2_k127_8206479_3	1007104.SUS17_3997	7.866e-23	103.0	COG1846@1|root,COG1846@2|Bacteria,1N2Q4@1224|Proteobacteria,2UC5A@28211|Alphaproteobacteria,2K54U@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27,MarR
HKD2_k127_8228572_0	1123487.KB892841_gene4301	4.071e-104	351.0	28JQB@1|root,2Z9G8@2|Bacteria,1QCH9@1224|Proteobacteria,2VJJF@28216|Betaproteobacteria,2KW13@206389|Rhodocyclales	206389|Rhodocyclales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8228572_2	1317118.ATO8_14162	2.678e-22	104.0	COG3474@1|root,COG3474@2|Bacteria,1MZGS@1224|Proteobacteria,2UCUT@28211|Alphaproteobacteria,4KMQE@93682|Roseivivax	28211|Alphaproteobacteria	C	Cytochrome c	cycA	-	-	ko:K08738	ko00920,ko01100,ko01120,ko01524,ko02020,ko04115,ko04210,ko04214,ko04215,ko04932,ko05010,ko05012,ko05014,ko05016,ko05134,ko05145,ko05152,ko05161,ko05164,ko05167,ko05168,ko05200,ko05210,ko05222,ko05416,map00920,map01100,map01120,map01524,map02020,map04115,map04210,map04214,map04215,map04932,map05010,map05012,map05014,map05016,map05134,map05145,map05152,map05161,map05164,map05167,map05168,map05200,map05210,map05222,map05416	M00595	R10151	RC03151,RC03152	ko00000,ko00001,ko00002	3.D.4.6	-	-	Cytochrom_C
HKD2_k127_8228572_1	1463920.JOGB01000036_gene6805	7.546e-100	338.0	COG0520@1|root,COG0520@2|Bacteria,2GJA4@201174|Actinobacteria	201174|Actinobacteria	E	Aminotransferase class v	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_5
HKD2_k127_8242600_0	323097.Nham_3076	2.037e-220	692.0	COG5659@1|root,COG5659@2|Bacteria,1MXSV@1224|Proteobacteria,2TRKD@28211|Alphaproteobacteria,3JTXJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	DDE superfamily endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	DDE_5
HKD2_k127_8293165_17	243233.MCA2283	5.633e-10	67.0	COG0439@1|root,COG0439@2|Bacteria,1NHC0@1224|Proteobacteria	1224|Proteobacteria	I	Biotin carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8293165_8	1463909.KL585959_gene1013	2.652e-114	375.0	COG0121@1|root,COG0121@2|Bacteria,2GXCD@201174|Actinobacteria	201174|Actinobacteria	S	Catalyzes the hydrolysis of the gamma-glutamyl amide bond of hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide to produce hercynylcysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine	-	-	-	-	-	-	-	-	-	-	-	-	GATase_4,GATase_6
HKD2_k127_8293165_9	1449049.JONW01000007_gene3910	3.302e-102	341.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2KFZA@204458|Caulobacterales	28211|Alphaproteobacteria	S	Polyphosphate kinase 2 (PPK2)	-	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_8293165_5	172088.AUGA01000019_gene1981	4.933e-232	732.0	COG0659@1|root,COG0659@2|Bacteria,1MWDF@1224|Proteobacteria,2TT0G@28211|Alphaproteobacteria,3JVT8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Sulfate permease family	-	-	-	-	-	-	-	-	-	-	-	-	STAS,Sulfate_transp
HKD2_k127_8293165_13	78245.Xaut_4916	2.286e-83	291.0	COG0845@1|root,COG0845@2|Bacteria,1MUG6@1224|Proteobacteria,2TTRG@28211|Alphaproteobacteria,3EZBK@335928|Xanthobacteraceae	28211|Alphaproteobacteria	M	PFAM secretion protein HlyD family protein	-	-	-	ko:K01993	-	-	-	-	ko00000	-	-	-	Biotin_lipoyl_2,HlyD_3,HlyD_D23
HKD2_k127_8293165_0	1449049.JONW01000005_gene1189	0.0	1361.0	COG0842@1|root,COG1129@1|root,COG0842@2|Bacteria,COG1129@2|Bacteria,1QTT9@1224|Proteobacteria,2TW58@28211|Alphaproteobacteria,2KICR@204458|Caulobacterales	204458|Caulobacterales	V	ABC-2 family transporter protein	-	-	-	ko:K13926	-	-	-	-	ko00000	-	-	-	ABC2_membrane_3,ABC_tran
HKD2_k127_8293165_6	1449049.JONW01000005_gene1188	4.319e-172	546.0	COG0842@1|root,COG0842@2|Bacteria,1MUIA@1224|Proteobacteria,2TU4P@28211|Alphaproteobacteria,2KJ21@204458|Caulobacterales	204458|Caulobacterales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_8293165_7	1449049.JONW01000005_gene1187	2.566e-152	495.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TSN8@28211|Alphaproteobacteria	28211|Alphaproteobacteria	MU	RND efflux system, outer membrane lipoprotein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_8293165_15	1219045.BV98_002583	1.117e-57	211.0	COG0642@1|root,COG0745@1|root,COG0745@2|Bacteria,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,2K2BZ@204457|Sphingomonadales	204457|Sphingomonadales	KT	Domain of unknown function (DUF4118)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4118,Trans_reg_C
HKD2_k127_8293165_11	380394.Lferr_0203	7.134e-99	338.0	2BZPA@1|root,2ZA2G@2|Bacteria,1NUVQ@1224|Proteobacteria,1SK2E@1236|Gammaproteobacteria,2NDQ1@225057|Acidithiobacillales	225057|Acidithiobacillales	S	Putative beta-barrel porin-2, OmpL-like. bbp2	-	-	-	-	-	-	-	-	-	-	-	-	BBP2
HKD2_k127_8293165_3	1379701.JPJC01000120_gene2117	5.225e-257	803.0	COG2060@1|root,COG2060@2|Bacteria,1MV1K@1224|Proteobacteria,2TSIJ@28211|Alphaproteobacteria,2K0P6@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane	kdpA	-	3.6.3.12	ko:K01546	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpA
HKD2_k127_8293165_2	314266.SKA58_01475	1.063e-317	984.0	COG2216@1|root,COG2216@2|Bacteria,1MU7D@1224|Proteobacteria,2TREM@28211|Alphaproteobacteria,2K0K4@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system	kdpB	-	3.6.3.12	ko:K01547	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	E1-E2_ATPase,Hydrolase
HKD2_k127_8293165_14	1123267.JONN01000001_gene1257	3.113e-66	232.0	COG2156@1|root,COG2156@2|Bacteria,1RABG@1224|Proteobacteria,2TSQ7@28211|Alphaproteobacteria,2K2ZB@204457|Sphingomonadales	204457|Sphingomonadales	P	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex	kdpC	-	3.6.3.12	ko:K01548	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	3.A.3.7	-	-	KdpC
HKD2_k127_8293165_1	627192.SLG_31030	0.0	1077.0	COG0642@1|root,COG2205@2|Bacteria,1MUZQ@1224|Proteobacteria,2TSS7@28211|Alphaproteobacteria,2K1GW@204457|Sphingomonadales	204457|Sphingomonadales	T	Osmosensitive K channel	kdpD	-	2.7.13.3	ko:K07646	ko02020,map02020	M00454	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	DUF4118,GAF_3,HATPase_c,HisKA,KdpD,Usp
HKD2_k127_8293165_12	627192.SLG_31020	7.969e-91	304.0	COG0745@1|root,COG0745@2|Bacteria,1MWZ5@1224|Proteobacteria,2TV3A@28211|Alphaproteobacteria,2K0MT@204457|Sphingomonadales	204457|Sphingomonadales	T	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain	kdpE	-	-	ko:K07667	ko02020,ko02024,map02020,map02024	M00454	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	Response_reg,Trans_reg_C
HKD2_k127_8293165_10	1449076.JOOE01000001_gene2200	1.176e-101	341.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_8293165_16	1346791.M529_13945	2.216e-49	187.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,2K4W9@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_8293165_4	420324.KI912025_gene67	1.896e-247	786.0	COG0474@1|root,COG0474@2|Bacteria,1MUU5@1224|Proteobacteria,2TRZD@28211|Alphaproteobacteria,1JSCQ@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	TIGRFAM ATPase, P-type (transporting), HAD superfamily, subfamily IC	-	-	3.6.3.8	ko:K01537	-	-	-	-	ko00000,ko01000	3.A.3.2	-	-	Cation_ATPase_C,Cation_ATPase_N,E1-E2_ATPase,Hydrolase,Hydrolase_3
HKD2_k127_847467_4	1219045.BV98_002774	1.185e-23	112.0	COG5419@1|root,COG5419@2|Bacteria	2|Bacteria	S	Uncharacterized conserved protein (DUF2285)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2285
HKD2_k127_847467_0	161528.ED21_25617	1.835e-96	342.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TS9V@28211|Alphaproteobacteria,2K1VI@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_847467_5	1150469.RSPPHO_01969	1.592e-22	100.0	COG3311@1|root,COG3311@2|Bacteria,1N77F@1224|Proteobacteria,2UFZC@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Helix-turn-helix domain	msi109	-	-	-	-	-	-	-	-	-	-	-	HTH_17
HKD2_k127_847467_2	555793.WSK_3463	1.596e-40	162.0	COG4959@1|root,COG4959@2|Bacteria,1MV1E@1224|Proteobacteria,2UA6F@28211|Alphaproteobacteria,2K42N@204457|Sphingomonadales	204457|Sphingomonadales	OU	Signal peptidase, peptidase S26	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S26
HKD2_k127_847467_1	1123269.NX02_19635	5.757e-49	184.0	COG0741@1|root,COG0741@2|Bacteria,1RHHP@1224|Proteobacteria,2UABC@28211|Alphaproteobacteria,2K4I0@204457|Sphingomonadales	204457|Sphingomonadales	M	Transglycosylase SLT domain	-	-	-	-	-	-	-	-	-	-	-	-	SLT
HKD2_k127_847467_3	331869.BAL199_02244	2.709e-25	113.0	COG0454@1|root,COG0456@2|Bacteria,1RIBM@1224|Proteobacteria,2UBNA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Acetyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_1
HKD2_k127_847467_6	1122970.AUHC01000001_gene434	9.022e-14	79.0	COG1846@1|root,COG1846@2|Bacteria,1NYW3@1224|Proteobacteria,2UTVX@28211|Alphaproteobacteria,2K6HH@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	HTH_27
HKD2_k127_8539882_1	330214.NIDE2123	5.05e-28	118.0	COG2801@1|root,COG2801@2|Bacteria	2|Bacteria	L	transposition	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_29,rve,rve_3
HKD2_k127_8539882_3	1424334.W822_05880	2.04e-10	63.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2VNA0@28216|Betaproteobacteria,3T61V@506|Alcaligenaceae	28216|Betaproteobacteria	L	Winged helix-turn helix	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve
HKD2_k127_8539882_0	1057002.KB905371_gene182	6.703e-186	585.0	COG3547@1|root,COG3547@2|Bacteria,1MUER@1224|Proteobacteria,2TSGZ@28211|Alphaproteobacteria,4BA6V@82115|Rhizobiaceae	28211|Alphaproteobacteria	L	Transposase (IS116 IS110 IS902 family)	-	-	-	-	-	-	-	-	-	-	-	-	DEDD_Tnp_IS110,Transposase_20
HKD2_k127_8539882_2	1121106.JQKB01000064_gene5382	9.273e-20	92.0	COG2801@1|root,COG2801@2|Bacteria,1MZ45@1224|Proteobacteria,2TTG7@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	InterPro IPR001584 COGs COG2801	-	-	-	-	-	-	-	-	-	-	-	-	HTH_29,rve,rve_3
HKD2_k127_8577346_11	1123267.JONN01000001_gene2399	3.866e-114	372.0	COG2274@1|root,COG2274@2|Bacteria,1R2T0@1224|Proteobacteria,2USBQ@28211|Alphaproteobacteria,2K0KD@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type bacteriocin lantibiotic exporters, contain an N-terminal double-glycine peptidase domain	-	-	-	ko:K12541	ko02010,map02010	M00330	-	-	ko00000,ko00001,ko00002,ko02000,ko02044	3.A.1.109.3,3.A.1.109.4	-	-	ABC_membrane,ABC_tran
HKD2_k127_8577346_13	1123267.JONN01000001_gene2400	8.749e-97	335.0	COG3773@1|root,COG3773@2|Bacteria,1MWX3@1224|Proteobacteria,2TT15@28211|Alphaproteobacteria,2K40Z@204457|Sphingomonadales	204457|Sphingomonadales	M	Cell Wall Hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Hydrolase_2
HKD2_k127_8577346_7	1123267.JONN01000001_gene2401	7.884e-170	542.0	COG0845@1|root,COG0845@2|Bacteria,1MUI8@1224|Proteobacteria,2TSP0@28211|Alphaproteobacteria,2K021@204457|Sphingomonadales	204457|Sphingomonadales	M	type I secretion membrane fusion protein	-	-	-	ko:K12542	-	M00330	-	-	ko00000,ko00002,ko02000,ko02044	3.A.1.109.4,8.A.1	-	-	Biotin_lipoyl_2,HlyD,HlyD_3,OEP
HKD2_k127_8577346_18	1219045.BV98_001042	8.273e-48	183.0	COG3672@1|root,COG3672@2|Bacteria,1RDQS@1224|Proteobacteria,2UDI9@28211|Alphaproteobacteria,2K5Q6@204457|Sphingomonadales	204457|Sphingomonadales	S	Bacterial transglutaminase-like cysteine proteinase BTLCP	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HKD2_k127_8577346_26	194867.ALBQ01000040_gene3154	1.321e-20	98.0	COG3652@1|root,COG3652@2|Bacteria,1N6QU@1224|Proteobacteria,2UF70@28211|Alphaproteobacteria,2K4I4@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4142)	-	-	-	ko:K08995	-	-	-	-	ko00000	-	-	-	DUF4142
HKD2_k127_8577346_24	1123267.JONN01000001_gene2127	1.121e-36	147.0	COG3672@1|root,COG3672@2|Bacteria	2|Bacteria	O	Periplasmic Protein	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_C93
HKD2_k127_8577346_27	1549858.MC45_09885	1.025e-19	102.0	COG0695@1|root,COG0695@2|Bacteria,1NZU3@1224|Proteobacteria,2UUCA@28211|Alphaproteobacteria,2K6F3@204457|Sphingomonadales	204457|Sphingomonadales	O	Glutaredoxin	-	-	-	-	-	-	-	-	-	-	-	-	Glutaredoxin
HKD2_k127_8577346_9	1123267.JONN01000001_gene1168	3.828e-135	440.0	COG0436@1|root,COG0436@2|Bacteria,1MW0Z@1224|Proteobacteria,2TTGJ@28211|Alphaproteobacteria,2K0KM@204457|Sphingomonadales	204457|Sphingomonadales	E	Aminotransferase	-	-	-	-	-	-	-	-	-	-	-	-	Aminotran_1_2
HKD2_k127_8577346_3	272943.RSP_1292	2.539e-204	647.0	COG1012@1|root,COG1012@2|Bacteria,1MW72@1224|Proteobacteria,2TUN4@28211|Alphaproteobacteria,1FB6E@1060|Rhodobacter	28211|Alphaproteobacteria	C	Belongs to the aldehyde dehydrogenase family	alh	GO:0003674,GO:0003824,GO:0004029,GO:0006081,GO:0008150,GO:0008152,GO:0009987,GO:0016491,GO:0016620,GO:0016903,GO:0044237,GO:0055114,GO:0071704	1.2.1.3	ko:K00128	ko00010,ko00053,ko00071,ko00280,ko00310,ko00330,ko00340,ko00380,ko00410,ko00561,ko00620,ko00625,ko00903,ko00981,ko01100,ko01110,ko01120,ko01130,map00010,map00053,map00071,map00280,map00310,map00330,map00340,map00380,map00410,map00561,map00620,map00625,map00903,map00981,map01100,map01110,map01120,map01130	M00135	R00264,R00631,R00710,R00904,R01752,R01986,R02549,R02678,R02940,R02957,R03283,R03869,R04065,R04506,R04903,R05050,R05237,R05238,R05286,R06366,R08146	RC00047,RC00071,RC00080,RC00186,RC00218,RC00242,RC00816,RC01500	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_8577346_12	1123267.JONN01000001_gene1169	1.529e-110	364.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TW2U@28211|Alphaproteobacteria,2KE9I@204457|Sphingomonadales	204457|Sphingomonadales	T	CHASE2	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,EAL
HKD2_k127_8577346_21	1123267.JONN01000001_gene1170	2.276e-42	159.0	COG0745@1|root,COG0745@2|Bacteria	1123267.JONN01000001_gene1170|-	T	phosphorelay signal transduction system	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8577346_16	1123267.JONN01000001_gene1172	2.247e-89	300.0	COG0225@1|root,COG0225@2|Bacteria,1MVUS@1224|Proteobacteria,2TSAM@28211|Alphaproteobacteria,2K0CZ@204457|Sphingomonadales	204457|Sphingomonadales	O	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine	msrA	-	1.8.4.11	ko:K07304	-	-	-	-	ko00000,ko01000	-	-	-	PMSR
HKD2_k127_8577346_10	1123267.JONN01000002_gene94	3.242e-127	413.0	COG0009@1|root,COG0009@2|Bacteria,1MVPM@1224|Proteobacteria,2TRIM@28211|Alphaproteobacteria,2K1JS@204457|Sphingomonadales	204457|Sphingomonadales	J	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine	-	-	2.7.7.87	ko:K07566	-	-	R10463	RC00745	ko00000,ko01000,ko03009,ko03016	-	-	-	SUA5,Sua5_yciO_yrdC
HKD2_k127_8577346_19	1123267.JONN01000002_gene96	2.499e-47	172.0	COG1725@1|root,COG1725@2|Bacteria,1MZG9@1224|Proteobacteria,2UBQ4@28211|Alphaproteobacteria,2K632@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K07979	-	-	-	-	ko00000,ko03000	-	-	-	GntR
HKD2_k127_8577346_17	1123267.JONN01000002_gene97	6.212e-62	219.0	COG0778@1|root,COG0778@2|Bacteria,1PKUV@1224|Proteobacteria,2U5MZ@28211|Alphaproteobacteria,2K422@204457|Sphingomonadales	204457|Sphingomonadales	C	nitroreductase	-	-	-	-	-	-	-	-	-	-	-	-	Nitroreductase
HKD2_k127_8577346_0	1112216.JH594425_gene1321	1.696e-280	874.0	COG3104@1|root,COG3104@2|Bacteria,1MW6W@1224|Proteobacteria,2U15C@28211|Alphaproteobacteria,2K05X@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid peptide transporter	-	-	-	ko:K03305	-	-	-	-	ko00000	2.A.17	-	-	PTR2
HKD2_k127_8577346_1	685778.AORL01000021_gene574	9.164e-234	733.0	COG1228@1|root,COG1228@2|Bacteria,1MXXR@1224|Proteobacteria,2TUMS@28211|Alphaproteobacteria,2K1BD@204457|Sphingomonadales	204457|Sphingomonadales	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_8577346_5	1123267.JONN01000002_gene100	9.379e-181	577.0	COG1228@1|root,COG1228@2|Bacteria,1MXQX@1224|Proteobacteria,2U1V8@28211|Alphaproteobacteria,2K2YY@204457|Sphingomonadales	204457|Sphingomonadales	Q	amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_1,Amidohydro_3
HKD2_k127_8577346_2	1123267.JONN01000002_gene102	5.858e-225	704.0	COG1109@1|root,COG1109@2|Bacteria,1MU24@1224|Proteobacteria,2TQWH@28211|Alphaproteobacteria,2JZV4@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate	glmM	-	5.4.2.10	ko:K03431	ko00520,ko01100,ko01130,map00520,map01100,map01130	-	R02060	RC00408	ko00000,ko00001,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_8577346_6	1123267.JONN01000002_gene103	5.023e-180	571.0	COG0346@1|root,COG0351@1|root,COG0346@2|Bacteria,COG0351@2|Bacteria,1MU9J@1224|Proteobacteria,2TUKR@28211|Alphaproteobacteria,2K24Q@204457|Sphingomonadales	204457|Sphingomonadales	H	Phosphomethylpyrimidine kinase	thiD	-	2.7.1.49,2.7.4.7	ko:K00941	ko00730,ko01100,map00730,map01100	M00127	R03471,R04509	RC00002,RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase,Phos_pyr_kin
HKD2_k127_8577346_15	1123267.JONN01000001_gene1173	3.934e-91	304.0	COG0164@1|root,COG0164@2|Bacteria,1RA65@1224|Proteobacteria,2U73X@28211|Alphaproteobacteria,2K1EB@204457|Sphingomonadales	204457|Sphingomonadales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhB	-	3.1.26.4	ko:K03470	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_HII
HKD2_k127_8577346_4	745310.G432_03240	1.228e-192	606.0	COG2189@1|root,COG2189@2|Bacteria,1MX9M@1224|Proteobacteria,2TSW9@28211|Alphaproteobacteria,2K0RE@204457|Sphingomonadales	204457|Sphingomonadales	L	Belongs to the N(4) N(6)-methyltransferase family	-	-	2.1.1.72	ko:K13581	ko04112,map04112	-	-	-	ko00000,ko00001,ko01000,ko02048	-	-	-	N6_N4_Mtase
HKD2_k127_8577346_8	745310.G432_03235	4.845e-137	444.0	COG0294@1|root,COG0294@2|Bacteria,1MUIR@1224|Proteobacteria,2TTMG@28211|Alphaproteobacteria,2K0EE@204457|Sphingomonadales	204457|Sphingomonadales	H	dihydropteroate synthase	folP	-	2.5.1.15	ko:K00796	ko00790,ko01100,map00790,map01100	M00126,M00841	R03066,R03067	RC00121,RC00842	ko00000,ko00001,ko00002,ko01000	-	-	-	Pterin_bind
HKD2_k127_8577346_23	392499.Swit_1233	5.207e-37	144.0	COG4254@1|root,COG4254@2|Bacteria,1N739@1224|Proteobacteria,2TY9V@28211|Alphaproteobacteria,2K5CY@204457|Sphingomonadales	204457|Sphingomonadales	S	FecR protein	-	-	-	-	-	-	-	-	-	-	-	-	FecR
HKD2_k127_8577346_20	392499.Swit_1234	7.631e-45	171.0	COG2885@1|root,COG2885@2|Bacteria,1MZKA@1224|Proteobacteria,2UG8A@28211|Alphaproteobacteria,2K64M@204457|Sphingomonadales	204457|Sphingomonadales	M	OmpA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_8577346_25	1297865.APJD01000062_gene3378	4.18e-25	117.0	COG0671@1|root,COG0671@2|Bacteria,1RKIU@1224|Proteobacteria,2UBF9@28211|Alphaproteobacteria,3JZM9@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	I	PAP2 superfamily	-	-	-	-	-	-	-	-	-	-	-	-	PAP2_3
HKD2_k127_8577346_22	1211777.BN77_0962	4.252e-37	143.0	COG5485@1|root,COG5485@2|Bacteria,1Q8EP@1224|Proteobacteria,2VEMA@28211|Alphaproteobacteria,4BEAS@82115|Rhizobiaceae	28211|Alphaproteobacteria	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HKD2_k127_8577346_28	1338011.BD94_2705	2.886e-10	63.0	COG4922@1|root,COG4922@2|Bacteria,4NNH5@976|Bacteroidetes,1I23M@117743|Flavobacteriia,34RF3@308865|Elizabethkingia	976|Bacteroidetes	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HKD2_k127_8706327_8	1267005.KB911263_gene1278	1.791e-06	50.0	COG0795@1|root,COG0795@2|Bacteria,1MVW3@1224|Proteobacteria,2TR76@28211|Alphaproteobacteria,3N79Z@45401|Hyphomicrobiaceae	28211|Alphaproteobacteria	S	permease YjgP YjgQ	lptG	-	-	ko:K11720	ko02010,map02010	M00320	-	-	ko00000,ko00001,ko00002,ko02000	1.B.42.1	-	-	YjgP_YjgQ
HKD2_k127_8706327_5	266835.14024709	2.982e-57	205.0	COG4635@1|root,COG4635@2|Bacteria,1RAH2@1224|Proteobacteria,2UB32@28211|Alphaproteobacteria,43QSH@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	CH	Flavodoxin domain	-	-	1.3.5.3	ko:K00230	ko00860,ko01100,ko01110,map00860,map01100,map01110	M00121	R09489	RC00885	ko00000,ko00001,ko00002,ko01000	-	-	-	Flavodoxin_5
HKD2_k127_8706327_3	1040989.AWZU01000004_gene7186	1.092e-132	429.0	COG1408@1|root,COG1408@2|Bacteria,1MUH5@1224|Proteobacteria,2U0JR@28211|Alphaproteobacteria,3JWTF@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Calcineurin-like phosphoesterase superfamily domain	-	-	-	ko:K07098	-	-	-	-	ko00000	-	-	-	Metallophos,Metallophos_2
HKD2_k127_8706327_6	663610.JQKO01000012_gene3096	1.938e-44	167.0	COG0575@1|root,COG0575@2|Bacteria,1N4I3@1224|Proteobacteria,2U7WC@28211|Alphaproteobacteria,3NCGR@45404|Beijerinckiaceae	28211|Alphaproteobacteria	I	CDP-archaeol synthase	-	-	2.7.7.67	ko:K19664	ko00564,map00564	-	R08966	RC00002	ko00000,ko00001,ko01000	-	-	-	CarS-like
HKD2_k127_8706327_7	1120956.JHZK01000014_gene1733	5.427e-22	98.0	COG0236@1|root,COG0236@2|Bacteria,1Q6PQ@1224|Proteobacteria,2VCSY@28211|Alphaproteobacteria,1JQCX@119043|Rhodobiaceae	28211|Alphaproteobacteria	IQ	Phosphopantetheine attachment site	-	-	-	-	-	-	-	-	-	-	-	-	PP-binding
HKD2_k127_8706327_4	631454.N177_1759	1.97e-132	436.0	COG0508@1|root,COG0508@2|Bacteria,1MUGY@1224|Proteobacteria,2TUU4@28211|Alphaproteobacteria,1JPR8@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	e3 binding domain	-	-	2.3.1.12	ko:K00627	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200	M00307	R00209,R02569	RC00004,RC02742,RC02857	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	2-oxoacid_dh,Biotin_lipoyl,E3_binding
HKD2_k127_8706327_1	631454.N177_1758	4.079e-165	525.0	COG0022@1|root,COG0022@2|Bacteria,1R8KB@1224|Proteobacteria,2TRFK@28211|Alphaproteobacteria,1JPNX@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Transketolase, pyrimidine binding domain	-	-	1.2.4.1	ko:K00162,ko:K21417	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Transket_pyr,Transketolase_C
HKD2_k127_8706327_2	631454.N177_1757	3.005e-151	484.0	COG1071@1|root,COG1071@2|Bacteria,1MU5R@1224|Proteobacteria,2TRW0@28211|Alphaproteobacteria,1JPV1@119043|Rhodobiaceae	28211|Alphaproteobacteria	C	Dehydrogenase E1 component	acoA	-	1.2.4.1	ko:K00161,ko:K21416	ko00010,ko00020,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko04066,ko04922,ko05230,map00010,map00020,map00620,map01100,map01110,map01120,map01130,map01200,map04066,map04922,map05230	M00307	R00014,R00209,R01699,R03270	RC00004,RC00027,RC00627,RC02742,RC02744,RC02882	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	E1_dh
HKD2_k127_8706327_0	631454.N177_1756	3.441e-216	677.0	COG0365@1|root,COG0365@2|Bacteria,1MUF5@1224|Proteobacteria,2TRII@28211|Alphaproteobacteria,1JPTS@119043|Rhodobiaceae	28211|Alphaproteobacteria	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.1	ko:K01895	ko00010,ko00620,ko00640,ko00680,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00620,map00640,map00680,map00720,map01100,map01110,map01120,map01130,map01200	M00357	R00235,R00236,R00316,R00926,R01354	RC00004,RC00012,RC00043,RC00070,RC02746,RC02816	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_8791040_2	864069.MicloDRAFT_00016190	1.655e-25	108.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,1JSJ8@119045|Methylobacteriaceae	28211|Alphaproteobacteria	T	diguanylate cyclase (GGDEF domain)	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF,PAS_3,PAS_4,PAS_9
HKD2_k127_8791040_1	1173023.KE650771_gene5116	1.732e-43	177.0	COG0642@1|root,COG0784@1|root,COG2199@1|root,COG2202@1|root,COG0784@2|Bacteria,COG2202@2|Bacteria,COG2205@2|Bacteria,COG3706@2|Bacteria,1G09B@1117|Cyanobacteria	1117|Cyanobacteria	T	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase	-	-	-	-	-	-	-	-	-	-	-	-	GAF,HATPase_c,HisKA,PAS_3,PAS_4,PAS_9,Response_reg
HKD2_k127_8791040_0	983920.Y88_1427	4.164e-61	214.0	COG2215@1|root,COG2215@2|Bacteria,1QDA1@1224|Proteobacteria,2TUN7@28211|Alphaproteobacteria,2K35J@204457|Sphingomonadales	204457|Sphingomonadales	S	Cytochrome C biogenesis protein transmembrane region	-	-	-	ko:K08970	-	-	-	-	ko00000,ko02000	2.A.52.2	-	-	NicO
HKD2_k127_8962104_44	1331060.RLDS_13120	3.987e-93	310.0	28KYY@1|root,2ZAEA@2|Bacteria,1RB7S@1224|Proteobacteria,2U6H6@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_35	314260.PB2503_12159	3.749e-128	419.0	COG2253@1|root,COG2253@2|Bacteria,1Q5VM@1224|Proteobacteria,2U2R3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD2_k127_8962104_55	765952.PUV_03410	1.637e-80	272.0	COG2818@1|root,COG2818@2|Bacteria,2JG0U@204428|Chlamydiae	204428|Chlamydiae	L	Methyladenine glycosylase	tag	-	3.2.2.20	ko:K01246	ko03410,map03410	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	Adenine_glyco
HKD2_k127_8962104_51	1007104.SUS17_446	1.887e-86	298.0	COG3243@1|root,COG3243@2|Bacteria,1Q6YK@1224|Proteobacteria,2TTVK@28211|Alphaproteobacteria,2K26F@204457|Sphingomonadales	204457|Sphingomonadales	I	COG3243 Poly(3-hydroxyalkanoate) synthetase	-	-	-	ko:K03821	ko00650,map00650	-	R04254	RC00004	ko00000,ko00001,ko01000	-	-	-	Abhydrolase_6
HKD2_k127_8962104_65	1123267.JONN01000002_gene46	9.118e-61	216.0	COG5394@1|root,COG5394@2|Bacteria,1RHRC@1224|Proteobacteria,2TQWQ@28211|Alphaproteobacteria,2K0W5@204457|Sphingomonadales	204457|Sphingomonadales	S	synthesis repressor PhaR	phaR	-	-	-	-	-	-	-	-	-	-	-	PHB_acc,PHB_acc_N
HKD2_k127_8962104_83	1081640.AGFU01000045_gene625	7.599e-20	94.0	2BR2H@1|root,3069A@2|Bacteria,1NG4W@1224|Proteobacteria,2UIK6@28211|Alphaproteobacteria,2KDMM@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_50	1502851.FG93_06075	1.493e-87	293.0	COG2095@1|root,COG2095@2|Bacteria,1MV1C@1224|Proteobacteria,2U89P@28211|Alphaproteobacteria,3K0K4@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	U	MarC family integral membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_8962104_8	1123269.NX02_03390	3.926e-249	781.0	COG1132@1|root,COG1132@2|Bacteria,1MUBM@1224|Proteobacteria,2TQMR@28211|Alphaproteobacteria,2K0VT@204457|Sphingomonadales	204457|Sphingomonadales	V	ABC-type multidrug transport system, ATPase and permease	-	-	-	ko:K06147	-	-	-	-	ko00000,ko02000	3.A.1.106,3.A.1.109,3.A.1.21	-	-	ABC_membrane,ABC_tran
HKD2_k127_8962104_24	394.NGR_c24320	2.194e-160	520.0	COG0076@1|root,COG0076@2|Bacteria,1MWUX@1224|Proteobacteria,2TTUK@28211|Alphaproteobacteria,4B92C@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	decarboxylase	rhbB	-	-	-	-	-	-	-	-	-	-	-	Pyridoxal_deC
HKD2_k127_8962104_14	1549858.MC45_06880	2e-201	633.0	COG4553@1|root,COG4553@2|Bacteria,1MVUH@1224|Proteobacteria,2TQXW@28211|Alphaproteobacteria,2K1W9@204457|Sphingomonadales	204457|Sphingomonadales	I	de-polymerase	phaZ	-	3.1.1.75	ko:K05973	ko00650,map00650	-	R05118	-	ko00000,ko00001,ko01000	-	-	-	PHB_depo_C
HKD2_k127_8962104_21	1123267.JONN01000001_gene1009	5.878e-166	534.0	COG0477@1|root,COG0477@2|Bacteria,1MWXZ@1224|Proteobacteria,2TT27@28211|Alphaproteobacteria,2K3H0@204457|Sphingomonadales	204457|Sphingomonadales	EGP	TIGRFAM drug resistance transporter, EmrB QacA subfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,MFS_3
HKD2_k127_8962104_82	1346791.M529_01110	1.141e-21	98.0	2BMCZ@1|root,32FX9@2|Bacteria,1Q6EX@1224|Proteobacteria,2VCK6@28211|Alphaproteobacteria,2K6Y7@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_75	1123267.JONN01000001_gene1010	7.066e-31	126.0	COG3631@1|root,COG3631@2|Bacteria,1RD0K@1224|Proteobacteria,2UGFJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	ko:K06893	-	-	-	-	ko00000	-	-	-	SnoaL_2
HKD2_k127_8962104_15	237727.NAP1_13983	9.145e-200	628.0	COG0183@1|root,COG0183@2|Bacteria,1MU5G@1224|Proteobacteria,2TQQ7@28211|Alphaproteobacteria,2K0V0@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the thiolase family	-	-	2.3.1.16,2.3.1.9	ko:K00626,ko:K00632	ko00071,ko00072,ko00280,ko00281,ko00310,ko00362,ko00380,ko00592,ko00620,ko00630,ko00640,ko00642,ko00650,ko00720,ko00900,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,ko02020,map00071,map00072,map00280,map00281,map00310,map00362,map00380,map00592,map00620,map00630,map00640,map00642,map00650,map00720,map00900,map01100,map01110,map01120,map01130,map01200,map01212,map02020	M00087,M00088,M00095,M00113,M00373,M00374,M00375	R00238,R00829,R00927,R01177,R03778,R03858,R03991,R04546,R04742,R04747,R05506,R05586,R07891,R07895,R07899,R08091,R08095	RC00004,RC00326,RC00405,RC01702,RC02728,RC02898,RC02955	ko00000,ko00001,ko00002,ko01000,ko04147	-	-	-	Thiolase_C,Thiolase_N
HKD2_k127_8962104_63	1123267.JONN01000001_gene1014	4.8e-62	217.0	COG2030@1|root,COG2030@2|Bacteria,1RHPH@1224|Proteobacteria,2U9GG@28211|Alphaproteobacteria,2K4IV@204457|Sphingomonadales	204457|Sphingomonadales	I	MaoC like domain	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_8962104_43	1123267.JONN01000001_gene1018	3.372e-97	329.0	COG0668@1|root,COG0668@2|Bacteria,1MXD2@1224|Proteobacteria,2TV9F@28211|Alphaproteobacteria,2K1C9@204457|Sphingomonadales	204457|Sphingomonadales	M	mechanosensitive ion channel	-	-	-	-	-	-	-	-	-	-	-	-	MS_channel
HKD2_k127_8962104_33	1123267.JONN01000001_gene1019	6.472e-137	444.0	COG3569@1|root,COG3569@2|Bacteria,1MVJ9@1224|Proteobacteria,2TUAH@28211|Alphaproteobacteria,2JZW2@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA topoisomerase	-	-	5.99.1.2	ko:K03168	-	-	-	-	ko00000,ko01000,ko03032,ko03400	-	-	-	Topoisom_I
HKD2_k127_8962104_61	1522072.IL54_1032	1.283e-63	223.0	COG0693@1|root,COG0693@2|Bacteria,1MY0C@1224|Proteobacteria,2U5BS@28211|Alphaproteobacteria,2K4S9@204457|Sphingomonadales	204457|Sphingomonadales	S	DJ-1/PfpI family	-	-	3.5.1.124	ko:K05520	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	DJ-1_PfpI
HKD2_k127_8962104_16	1007104.SUS17_2642	1.527e-199	643.0	COG0729@1|root,COG0729@2|Bacteria,1MUKM@1224|Proteobacteria,2TRWD@28211|Alphaproteobacteria,2JZVN@204457|Sphingomonadales	204457|Sphingomonadales	M	COG0729 Outer membrane protein	-	-	-	ko:K07278	-	-	-	-	ko00000,ko02000	1.B.33.2.4	-	-	Bac_surface_Ag,POTRA
HKD2_k127_8962104_2	1123269.NX02_08185	0.0	1356.0	COG2911@1|root,COG2911@2|Bacteria,1MUVD@1224|Proteobacteria,2TR45@28211|Alphaproteobacteria,2K0C4@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09800	-	-	-	-	ko00000,ko02000	-	-	-	TamB
HKD2_k127_8962104_85	1219049.SP5_060_00020	1.425e-18	88.0	29WB0@1|root,30HWH@2|Bacteria,1N3IB@1224|Proteobacteria,2UDM1@28211|Alphaproteobacteria,2K62V@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	ko:K06078	-	-	-	-	ko00000,ko01011	-	-	-	-
HKD2_k127_8962104_71	1470591.BW41_01974	1.35e-54	202.0	COG1376@1|root,COG1376@2|Bacteria,1R7VK@1224|Proteobacteria,2UPBM@28211|Alphaproteobacteria,2K2IN@204457|Sphingomonadales	204457|Sphingomonadales	S	ErfK ybiS ycfS ynhG family protein	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_18	1174684.EBMC1_14203	5.655e-190	603.0	COG0531@1|root,COG0531@2|Bacteria,1MXNJ@1224|Proteobacteria,2TRNX@28211|Alphaproteobacteria,2K03C@204457|Sphingomonadales	204457|Sphingomonadales	E	amino acid	-	-	-	ko:K03294	-	-	-	-	ko00000	2.A.3.2	-	-	AA_permease_2
HKD2_k127_8962104_47	1449076.JOOE01000002_gene801	8.55e-91	316.0	COG1287@1|root,COG1287@2|Bacteria	2|Bacteria	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	DUF2723
HKD2_k127_8962104_59	1123267.JONN01000001_gene1029	1.295e-67	240.0	2AM82@1|root,31C2W@2|Bacteria,1P3W8@1224|Proteobacteria,2UVCJ@28211|Alphaproteobacteria,2KB9A@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_8962104_4	1123267.JONN01000001_gene1030	4.023e-276	854.0	COG0174@1|root,COG0174@2|Bacteria,1MUGQ@1224|Proteobacteria,2TSCR@28211|Alphaproteobacteria,2K06N@204457|Sphingomonadales	204457|Sphingomonadales	E	highly regulated protein controlled by the addition removal of adenylyl groups by adenylyltransferase from specific tyrosine residues	glnA	-	6.3.1.2	ko:K01915	ko00220,ko00250,ko00630,ko00910,ko01100,ko01120,ko01230,ko02020,ko04217,ko04724,ko04727,map00220,map00250,map00630,map00910,map01100,map01120,map01230,map02020,map04217,map04724,map04727	-	R00253	RC00010,RC02798	ko00000,ko00001,ko01000,ko04147	-	-	-	Gln-synt_C,Gln-synt_N
HKD2_k127_8962104_46	1248916.ANFY01000004_gene1677	4.064e-91	308.0	COG0730@1|root,COG0730@2|Bacteria,1R6MR@1224|Proteobacteria,2URRK@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Sulfite exporter TauE/SafE	-	-	-	-	-	-	-	-	-	-	-	-	TauE
HKD2_k127_8962104_48	1219049.SP5_018_00910	2.996e-90	304.0	COG0723@1|root,COG0723@2|Bacteria,1RAA2@1224|Proteobacteria,2TTT2@28211|Alphaproteobacteria,2K1YX@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	petA	-	1.10.2.2	ko:K00411	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko01000	-	-	-	Rieske,UCR_Fe-S_N
HKD2_k127_8962104_11	194867.ALBQ01000059_gene3276	1.884e-221	702.0	COG1290@1|root,COG1290@2|Bacteria,1MV97@1224|Proteobacteria,2TSZ3@28211|Alphaproteobacteria,2K0CE@204457|Sphingomonadales	204457|Sphingomonadales	C	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis	-	-	-	ko:K00412	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002,ko03029	-	-	-	Cytochrom_B_C,Cytochrome_B
HKD2_k127_8962104_36	1123267.JONN01000001_gene544	5.98e-126	409.0	COG2857@1|root,COG2857@2|Bacteria,1QFU2@1224|Proteobacteria,2TUHX@28211|Alphaproteobacteria,2K07X@204457|Sphingomonadales	204457|Sphingomonadales	C	Cytochrome c1	petC	-	-	ko:K00413	ko00190,ko01100,ko02020,ko04260,ko04714,ko04932,ko05010,ko05012,ko05016,map00190,map01100,map02020,map04260,map04714,map04932,map05010,map05012,map05016	M00151,M00152	-	-	ko00000,ko00001,ko00002	-	-	-	Cytochrom_C1
HKD2_k127_8962104_13	1174684.EBMC1_10224	1.217e-212	673.0	COG2234@1|root,COG2234@2|Bacteria,1MWQ0@1224|Proteobacteria,2U1HX@28211|Alphaproteobacteria,2JZUX@204457|Sphingomonadales	204457|Sphingomonadales	S	Peptidase family M28	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M28
HKD2_k127_8962104_84	1123267.JONN01000002_gene123	1.512e-19	95.0	28RMB@1|root,2ZE02@2|Bacteria,1P04A@1224|Proteobacteria,2UV0Q@28211|Alphaproteobacteria,2K50J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_69	1112212.JH584235_gene1308	1.322e-56	203.0	COG2030@1|root,COG2030@2|Bacteria,1RIBV@1224|Proteobacteria,2U9QR@28211|Alphaproteobacteria,2K4JQ@204457|Sphingomonadales	204457|Sphingomonadales	I	dehydratase	-	-	-	-	-	-	-	-	-	-	-	-	MaoC_dehydratas
HKD2_k127_8962104_20	1449076.JOOE01000002_gene1028	1.124e-184	602.0	COG1680@1|root,COG1680@2|Bacteria,1MVZN@1224|Proteobacteria,2VF7X@28211|Alphaproteobacteria,2KDW0@204457|Sphingomonadales	204457|Sphingomonadales	V	Beta-lactamase class C	-	-	-	-	-	-	-	-	-	-	-	-	Beta-lactamase,DUF3471
HKD2_k127_8962104_12	1112212.JH584235_gene1438	3.235e-215	683.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K04M@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_19,TPR_8
HKD2_k127_8962104_5	1123267.JONN01000001_gene2395	5.646e-271	860.0	COG1629@1|root,COG1629@2|Bacteria,1QUTW@1224|Proteobacteria,2TW7F@28211|Alphaproteobacteria,2KECH@204457|Sphingomonadales	204457|Sphingomonadales	P	TonB-dependent Receptor Plug Domain	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_8962104_78	1121116.KB894777_gene1886	2.443e-26	117.0	COG0671@1|root,COG0671@2|Bacteria,1RDK3@1224|Proteobacteria,2WEGV@28216|Betaproteobacteria	28216|Betaproteobacteria	I	Acid phosphatase homologues	-	-	3.6.1.27	ko:K19302	ko00550,map00550	-	R05627	RC00002	ko00000,ko00001,ko01000,ko01011	-	-	-	PAP2
HKD2_k127_8962104_19	1090320.KB900605_gene626	6.916e-189	595.0	COG0012@1|root,COG0012@2|Bacteria,1MVM4@1224|Proteobacteria,2TRAD@28211|Alphaproteobacteria,2K213@204457|Sphingomonadales	204457|Sphingomonadales	J	ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner	ychF	-	-	ko:K06942	-	-	-	-	ko00000,ko03009	-	-	-	MMR_HSR1,YchF-GTPase_C
HKD2_k127_8962104_54	1123267.JONN01000001_gene553	3.87e-81	274.0	COG3063@1|root,COG3063@2|Bacteria	2|Bacteria	NU	photosynthesis	-	-	-	-	-	-	-	-	-	-	-	-	ANAPC5,Peptidase_C39_2,Rhomboid,TPR_16,TPR_19,TPR_8
HKD2_k127_8962104_6	1234595.C725_0633	1.463e-267	847.0	COG1913@1|root,COG1913@2|Bacteria,1MY52@1224|Proteobacteria,2TUDY@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF5117)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4953,DUF5117
HKD2_k127_8962104_77	1458357.BG58_17005	2.475e-29	120.0	COG0662@1|root,COG0662@2|Bacteria,1PXVV@1224|Proteobacteria,2WD6R@28216|Betaproteobacteria,1K9II@119060|Burkholderiaceae	28216|Betaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_8962104_41	1123267.JONN01000001_gene555	5.151e-102	334.0	COG0193@1|root,COG0193@2|Bacteria,1MX1P@1224|Proteobacteria,2TT6Q@28211|Alphaproteobacteria,2K0UK@204457|Sphingomonadales	204457|Sphingomonadales	J	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis	pth	-	3.1.1.29	ko:K01056	-	-	-	-	ko00000,ko01000,ko03012	-	-	-	Pept_tRNA_hydro
HKD2_k127_8962104_52	1123267.JONN01000001_gene556	2.67e-86	292.0	COG1825@1|root,COG1825@2|Bacteria,1RDH0@1224|Proteobacteria,2U5P0@28211|Alphaproteobacteria,2K122@204457|Sphingomonadales	204457|Sphingomonadales	J	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance	ctc	-	-	ko:K02897	ko03010,map03010	M00178	-	-	ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L25p,Ribosomal_TL5_C
HKD2_k127_8962104_72	1123267.JONN01000001_gene1457	8.246e-53	196.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD2_k127_8962104_45	1123267.JONN01000001_gene1456	2.08e-91	309.0	COG3735@1|root,COG3735@2|Bacteria,1MVCW@1224|Proteobacteria,2U5RA@28211|Alphaproteobacteria,2JZWN@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K09973	-	-	-	-	ko00000	-	-	-	TraB
HKD2_k127_8962104_22	685778.AORL01000014_gene2248	2.892e-163	517.0	COG0752@1|root,COG0752@2|Bacteria,1MVCJ@1224|Proteobacteria,2TS2N@28211|Alphaproteobacteria,2K1RK@204457|Sphingomonadales	204457|Sphingomonadales	J	glycyl-tRNA synthetase alpha subunit	glyQ	-	6.1.1.14	ko:K01878	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_2e
HKD2_k127_8962104_7	1090318.ATTI01000001_gene2277	2.448e-267	842.0	COG0751@1|root,COG0751@2|Bacteria,1MV2F@1224|Proteobacteria,2TQKJ@28211|Alphaproteobacteria,2K16M@204457|Sphingomonadales	204457|Sphingomonadales	J	Glycyl-tRNA synthetase beta subunit	glyS	-	6.1.1.14	ko:K01879	ko00970,map00970	M00360	R03654	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DALR_1,tRNA_synt_2f
HKD2_k127_8962104_23	1123267.JONN01000001_gene1452	2.932e-163	518.0	COG2064@1|root,COG2064@2|Bacteria,1MWAZ@1224|Proteobacteria,2TSFA@28211|Alphaproteobacteria,2K03P@204457|Sphingomonadales	204457|Sphingomonadales	NU	type II secretion system protein	-	-	-	ko:K12511	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_8962104_32	1123267.JONN01000001_gene1451	3.538e-138	445.0	COG4965@1|root,COG4965@2|Bacteria,1MUXK@1224|Proteobacteria,2TRBI@28211|Alphaproteobacteria,2K0B5@204457|Sphingomonadales	204457|Sphingomonadales	U	pilus assembly protein TadB	-	-	-	ko:K12510	-	-	-	-	ko00000,ko02044	-	-	-	T2SSF
HKD2_k127_8962104_9	1123267.JONN01000001_gene1450	8.973e-232	723.0	COG2204@1|root,COG4963@1|root,COG2204@2|Bacteria,COG4963@2|Bacteria,1MWNY@1224|Proteobacteria,2TUDS@28211|Alphaproteobacteria,2K0BT@204457|Sphingomonadales	204457|Sphingomonadales	TU	Flp pilus assembly protein, ATPase CpaE	cpaE	-	-	ko:K02282	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	CbiA,ParA
HKD2_k127_8962104_62	1123267.JONN01000001_gene1449	9.177e-63	227.0	COG5461@1|root,COG5461@2|Bacteria,1REYP@1224|Proteobacteria,2U8J3@28211|Alphaproteobacteria,2K5AY@204457|Sphingomonadales	204457|Sphingomonadales	N	Pilus assembly protein CpaD	cpaD	-	-	ko:K02281	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	Pilus_CpaD
HKD2_k127_8962104_17	1123267.JONN01000001_gene1448	1.333e-192	624.0	COG4964@1|root,COG4964@2|Bacteria,1MV8G@1224|Proteobacteria,2TRNN@28211|Alphaproteobacteria,2K0ZQ@204457|Sphingomonadales	204457|Sphingomonadales	U	Belongs to the GSP D family	cpaC	-	-	ko:K02280	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	BON,Secretin,T2SS-T3SS_pil_N
HKD2_k127_8962104_31	1123267.JONN01000001_gene1447	2.441e-144	465.0	COG3745@1|root,COG3745@2|Bacteria,1MW75@1224|Proteobacteria,2TTPE@28211|Alphaproteobacteria,2K08W@204457|Sphingomonadales	204457|Sphingomonadales	U	Pilus assembly protein CpaB	cpaB	-	-	ko:K02279	-	-	-	-	ko00000,ko02035,ko02044	-	-	-	RcpC,SAF
HKD2_k127_8962104_74	1207055.C100_05075	3.994e-37	152.0	COG4960@1|root,COG4960@2|Bacteria,1RAYG@1224|Proteobacteria,2UJT9@28211|Alphaproteobacteria,2K6EK@204457|Sphingomonadales	204457|Sphingomonadales	OU	peptidase	cpaA	-	3.4.23.43	ko:K02278	-	-	-	-	ko00000,ko01000,ko02035,ko02044	-	-	-	Peptidase_A24
HKD2_k127_8962104_38	1123269.NX02_04735	3.883e-119	399.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2JZYS@204457|Sphingomonadales	204457|Sphingomonadales	E	Oxidoreductase	-	-	1.4.99.6	ko:K19746	ko00472,ko01100,map00472,map01100	-	R11018	RC00006	ko00000,ko00001,ko01000	-	-	-	DAO
HKD2_k127_8962104_56	629773.AORY01000004_gene358	1.402e-71	244.0	COG0328@1|root,COG0328@2|Bacteria,1RCZ1@1224|Proteobacteria,2U7C4@28211|Alphaproteobacteria,2K3YC@204457|Sphingomonadales	204457|Sphingomonadales	L	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids	rnhA	-	3.1.26.4	ko:K03469	ko03030,map03030	-	-	-	ko00000,ko00001,ko01000,ko03032	-	-	-	RNase_H
HKD2_k127_8962104_30	1123267.JONN01000001_gene1444	2.191e-145	481.0	COG0761@1|root,COG0761@2|Bacteria,1MU7G@1224|Proteobacteria,2TRNR@28211|Alphaproteobacteria,2K1ES@204457|Sphingomonadales	204457|Sphingomonadales	IM	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis	ispH	-	1.17.7.4	ko:K03527	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05884,R08210	RC01137,RC01487	ko00000,ko00001,ko00002,ko01000	-	-	-	LYTB
HKD2_k127_8962104_60	1123267.JONN01000001_gene1443	5.537e-65	229.0	2B5IK@1|root,31YDD@2|Bacteria,1RAZF@1224|Proteobacteria,2U6F0@28211|Alphaproteobacteria,2K43H@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_25	1123267.JONN01000001_gene1440	3.602e-152	490.0	COG0404@1|root,COG0404@2|Bacteria,1MV96@1224|Proteobacteria,2TRN4@28211|Alphaproteobacteria,2K1GI@204457|Sphingomonadales	204457|Sphingomonadales	E	Glycine cleavage system T protein	gcvT	-	2.1.2.10	ko:K00605	ko00260,ko00630,ko00670,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map00670,map01100,map01110,map01130,map01200	M00532	R01221,R02300,R04125	RC00022,RC00069,RC00183,RC02834	ko00000,ko00001,ko00002,ko01000	-	-	-	GCV_T,GCV_T_C
HKD2_k127_8962104_64	1123267.JONN01000001_gene1439	1.538e-61	216.0	COG0509@1|root,COG0509@2|Bacteria,1RGV7@1224|Proteobacteria,2U9BY@28211|Alphaproteobacteria,2K5E0@204457|Sphingomonadales	204457|Sphingomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein	gcvH	-	-	ko:K02437	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	M00532	R01221	RC00022,RC02834	ko00000,ko00001,ko00002	-	-	-	GCV_H
HKD2_k127_8962104_42	1123267.JONN01000001_gene1438	1.382e-100	339.0	COG4106@1|root,COG4106@2|Bacteria,1R04W@1224|Proteobacteria,2U5VR@28211|Alphaproteobacteria,2K298@204457|Sphingomonadales	204457|Sphingomonadales	S	Methionine biosynthesis protein MetW	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_8962104_10	1112214.AHIS01000071_gene3179	1.382e-231	725.0	COG0403@1|root,COG0403@2|Bacteria,1MVC1@1224|Proteobacteria,2TR6C@28211|Alphaproteobacteria,2K0IW@204457|Sphingomonadales	204457|Sphingomonadales	E	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor	gcvPA	-	1.4.4.2	ko:K00282	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	GDC-P
HKD2_k127_8962104_3	1123267.JONN01000001_gene1436	3.707e-290	899.0	COG1003@1|root,COG1003@2|Bacteria,1MUDP@1224|Proteobacteria,2TSFF@28211|Alphaproteobacteria,2K1GP@204457|Sphingomonadales	204457|Sphingomonadales	E	Glycine dehydrogenase (aminomethyl-transferring)	gcvPB	-	1.4.4.2	ko:K00283	ko00260,ko00630,ko01100,ko01110,ko01130,ko01200,map00260,map00630,map01100,map01110,map01130,map01200	-	R01221,R03425	RC00022,RC00929,RC02834,RC02880	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD2_k127_8962104_58	1449076.JOOE01000001_gene2944	1.293e-67	237.0	COG0220@1|root,COG0220@2|Bacteria,1QTX5@1224|Proteobacteria,2TWA0@28211|Alphaproteobacteria,2KED9@204457|Sphingomonadales	204457|Sphingomonadales	J	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
HKD2_k127_8962104_80	1457393.AZ09_08105	2.154e-22	98.0	COG1724@1|root,COG1724@2|Bacteria,1N7S3@1224|Proteobacteria,2UGAG@28211|Alphaproteobacteria,2JUDI@204441|Rhodospirillales	204441|Rhodospirillales	N	HicA toxin of bacterial toxin-antitoxin,	-	-	-	-	-	-	-	-	-	-	-	-	HicA_toxin
HKD2_k127_8962104_76	1123269.NX02_23640	7.953e-30	123.0	COG1598@1|root,COG1598@2|Bacteria,1N2X7@1224|Proteobacteria,2UA2Y@28211|Alphaproteobacteria,2K5QZ@204457|Sphingomonadales	204457|Sphingomonadales	S	HicB_like antitoxin of bacterial toxin-antitoxin system	-	-	-	-	-	-	-	-	-	-	-	-	HicB_lk_antitox
HKD2_k127_8962104_92	1207055.C100_01105	5.33e-08	54.0	COG2813@1|root,COG2813@2|Bacteria,1RHAE@1224|Proteobacteria,2U5V5@28211|Alphaproteobacteria,2K42K@204457|Sphingomonadales	204457|Sphingomonadales	J	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
HKD2_k127_8962104_96	570952.ATVH01000014_gene2032	7.517e-06	48.0	COG0220@1|root,COG0220@2|Bacteria,1QTX5@1224|Proteobacteria,2TWA0@28211|Alphaproteobacteria,2JRPF@204441|Rhodospirillales	204441|Rhodospirillales	J	Protein of unknown function (DUF938)	-	-	-	-	-	-	-	-	-	-	-	-	DUF938
HKD2_k127_8962104_66	1123267.JONN01000001_gene1430	1.13e-59	213.0	2AKT1@1|root,31BK2@2|Bacteria,1NXBB@1224|Proteobacteria,2UTRK@28211|Alphaproteobacteria,2K5KP@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_8962104_57	1123267.JONN01000001_gene1429	1.926e-70	250.0	COG3577@1|root,COG3577@2|Bacteria,1MYAD@1224|Proteobacteria,2U9RE@28211|Alphaproteobacteria,2K4GD@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	-	-	-	-	-	-	-	-	-	Asp_protease_2,gag-asp_proteas
HKD2_k127_8962104_37	1123267.JONN01000002_gene72	1.673e-123	402.0	COG0496@1|root,COG0496@2|Bacteria,1MVHE@1224|Proteobacteria,2TQXZ@28211|Alphaproteobacteria,2K0F4@204457|Sphingomonadales	204457|Sphingomonadales	S	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates	surE	-	3.1.3.5	ko:K03787	ko00230,ko00240,ko00760,ko01100,ko01110,map00230,map00240,map00760,map01100,map01110	-	R00183,R00511,R00963,R01126,R01227,R01569,R01664,R01968,R02088,R02102,R02323,R02719,R03346	RC00017	ko00000,ko00001,ko01000	-	-	-	SurE
HKD2_k127_8962104_67	1123267.JONN01000002_gene73	1.374e-57	206.0	COG1734@1|root,COG1734@2|Bacteria,1RD08@1224|Proteobacteria,2U74V@28211|Alphaproteobacteria,2K4GE@204457|Sphingomonadales	204457|Sphingomonadales	T	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters	dksA	-	-	ko:K06204	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000,ko03009,ko03021	-	-	-	zf-dskA_traR
HKD2_k127_8962104_90	1123267.JONN01000002_gene74	3.183e-09	64.0	COG5570@1|root,COG5570@2|Bacteria,1NGRE@1224|Proteobacteria,2UJAX@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Small protein	-	-	-	-	-	-	-	-	-	-	-	-	DUF465
HKD2_k127_8962104_68	1123267.JONN01000002_gene76	5.596e-57	204.0	COG5317@1|root,COG5317@2|Bacteria,1RJIA@1224|Proteobacteria,2U9ID@28211|Alphaproteobacteria,2K5B1@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1465)	-	-	-	ko:K13592	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	DUF1465
HKD2_k127_8962104_26	1120705.FG95_01284	9.274e-152	486.0	COG2070@1|root,COG2070@2|Bacteria,1MU0U@1224|Proteobacteria,2TS5U@28211|Alphaproteobacteria,2K0V5@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD2_k127_8962104_27	1112216.JH594425_gene732	1.583e-151	486.0	COG0451@1|root,COG0451@2|Bacteria,1MU7J@1224|Proteobacteria,2TSIP@28211|Alphaproteobacteria,2K0VH@204457|Sphingomonadales	204457|Sphingomonadales	M	epimerase dehydratase	-	-	5.1.3.6	ko:K08679	ko00520,ko01100,map00520,map01100	-	R01385	RC00289	ko00000,ko00001,ko01000	-	-	-	Epimerase,GDP_Man_Dehyd
HKD2_k127_8962104_0	314225.ELI_09260	0.0	1662.0	COG0145@1|root,COG0146@1|root,COG0145@2|Bacteria,COG0146@2|Bacteria,1MU2Y@1224|Proteobacteria,2TQZ6@28211|Alphaproteobacteria,2K2G6@204457|Sphingomonadales	204457|Sphingomonadales	EQ	COG0145 N-methylhydantoinase A acetone carboxylase, beta subunit	-	-	3.5.2.9	ko:K01469	ko00480,map00480	-	R00251	RC00553	ko00000,ko00001,ko01000	-	-	-	Hydant_A_N,Hydantoinase_A,Hydantoinase_B
HKD2_k127_8962104_53	1044.EH31_00290	4.732e-84	285.0	COG3819@1|root,COG3819@2|Bacteria,1MWFM@1224|Proteobacteria,2U5DR@28211|Alphaproteobacteria,2K0TR@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF969
HKD2_k127_8962104_39	685035.ADAE01000008_gene2928	1.329e-109	374.0	COG3817@1|root,COG3817@2|Bacteria,1MXGD@1224|Proteobacteria,2TUDC@28211|Alphaproteobacteria,2K1SX@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	DUF979
HKD2_k127_8962104_34	629773.AORY01000005_gene2616	4.316e-135	438.0	2C57D@1|root,2Z7RS@2|Bacteria,1MX6G@1224|Proteobacteria,2TTDU@28211|Alphaproteobacteria,2K0FT@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2891)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2891
HKD2_k127_8962104_70	1110697.NCAST_08_00250	2.147e-56	215.0	COG3491@1|root,COG3491@2|Bacteria,2GT52@201174|Actinobacteria,4FXD4@85025|Nocardiaceae	201174|Actinobacteria	C	Belongs to the iron ascorbate-dependent oxidoreductase family	-	-	-	-	-	-	-	-	-	-	-	-	2OG-FeII_Oxy,DIOX_N
HKD2_k127_8962104_29	1090320.KB900605_gene518	1.18e-147	486.0	COG1538@1|root,COG1538@2|Bacteria,1MUA8@1224|Proteobacteria,2TUFK@28211|Alphaproteobacteria,2K0NW@204457|Sphingomonadales	204457|Sphingomonadales	M	RND efflux system, outer membrane lipoprotein	-	-	-	ko:K18139	ko01501,ko02024,map01501,map02024	M00642,M00643,M00647,M00718,M00768,M00822	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	1.B.17,2.A.6.2	-	-	OEP
HKD2_k127_8962104_1	194867.ALBQ01000012_gene711	0.0	1450.0	COG0841@1|root,COG0841@2|Bacteria,1MU48@1224|Proteobacteria,2TQT0@28211|Alphaproteobacteria,2K02H@204457|Sphingomonadales	204457|Sphingomonadales	V	Efflux pump membrane transporter	-	-	-	ko:K18138	ko01501,ko01503,map01501,map01503	M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000	2.A.6.2	-	-	ACR_tran
HKD2_k127_8962104_28	1081640.AGFU01000100_gene2035	2.664e-149	483.0	COG0845@1|root,COG0845@2|Bacteria,1MU78@1224|Proteobacteria,2TSW4@28211|Alphaproteobacteria,2K1BG@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family	-	-	-	ko:K03585	ko01501,ko01503,map01501,map01503	M00646,M00647,M00699,M00718	-	-	ko00000,ko00001,ko00002,ko01504,ko02000,ko03036	2.A.6.2,8.A.1.6	-	-	HlyD,HlyD_D23
HKD2_k127_8962104_49	1304275.C41B8_00915	2.701e-89	309.0	COG0189@1|root,COG0189@2|Bacteria	2|Bacteria	HJ	Glutathione synthase Ribosomal protein S6 modification enzyme (Glutaminyl transferase)	-	-	-	-	-	-	-	-	-	-	-	-	ATPgrasp_ST,RimK
HKD2_k127_8962104_40	1217720.ALOX01000033_gene137	1.112e-105	350.0	COG1442@1|root,COG1442@2|Bacteria,1R5NA@1224|Proteobacteria,2U2U3@28211|Alphaproteobacteria,2JS2F@204441|Rhodospirillales	204441|Rhodospirillales	M	glycosyl transferase family 8	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8962104_73	1336208.JADY01000010_gene3349	2.287e-51	194.0	COG3660@1|root,COG3660@2|Bacteria,1R70U@1224|Proteobacteria,2TQWV@28211|Alphaproteobacteria,2JTHZ@204441|Rhodospirillales	204441|Rhodospirillales	M	Mitochondrial fission ELM1	-	-	-	ko:K07276	-	-	-	-	ko00000	-	-	-	Mito_fiss_Elm1
HKD2_k127_8968728_7	69395.JQLZ01000004_gene783	6.412e-18	84.0	COG0842@1|root,COG0842@2|Bacteria,1MW5R@1224|Proteobacteria,2TU59@28211|Alphaproteobacteria,2KFZ9@204458|Caulobacterales	204458|Caulobacterales	V	ABC-2 family transporter protein	-	-	-	ko:K01992	-	M00254	-	-	ko00000,ko00002,ko02000	3.A.1	-	-	ABC2_membrane_3
HKD2_k127_8968728_4	1123267.JONN01000001_gene1735	4.474e-66	232.0	COG3038@1|root,COG3038@2|Bacteria,1MZ7X@1224|Proteobacteria,2UBYU@28211|Alphaproteobacteria,2K63Z@204457|Sphingomonadales	204457|Sphingomonadales	C	Prokaryotic cytochrome b561	-	-	-	ko:K12262	-	-	-	-	ko00000	-	-	-	Ni_hydr_CYTB
HKD2_k127_8968728_0	1123267.JONN01000001_gene1733	0.0	1050.0	COG1024@1|root,COG1250@1|root,COG1024@2|Bacteria,COG1250@2|Bacteria,1MU9P@1224|Proteobacteria,2TS8E@28211|Alphaproteobacteria,2K0RP@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the enoyl-CoA hydratase isomerase family	-	-	1.1.1.35	ko:K07516	ko00071,ko00362,ko00650,ko01100,ko01120,ko01200,ko01212,map00071,map00362,map00650,map01100,map01120,map01200,map01212	M00087	R01975,R04737,R04739,R04741,R04743,R04745,R04748,R05305	RC00029,RC00117	ko00000,ko00001,ko00002,ko01000	-	-	-	3HCDH,3HCDH_N,ECH_1
HKD2_k127_8968728_6	1346791.M529_16200	2.543e-35	141.0	COG2149@1|root,COG2149@2|Bacteria,1RJJ7@1224|Proteobacteria,2UA2E@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD2_k127_8968728_8	1545915.JROG01000004_gene2452	1.01e-08	65.0	2AE8J@1|root,3142J@2|Bacteria,1P7XY@1224|Proteobacteria,2UX9M@28211|Alphaproteobacteria,2K7W8@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_8968728_5	745310.G432_17765	4.529e-36	138.0	COG1828@1|root,COG1828@2|Bacteria,1N83G@1224|Proteobacteria,2UF7S@28211|Alphaproteobacteria,2K5YV@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purS	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	PurS
HKD2_k127_8968728_3	317655.Sala_0591	8.729e-115	373.0	COG0047@1|root,COG0047@2|Bacteria,1MU4Y@1224|Proteobacteria,2TS67@28211|Alphaproteobacteria,2K0NC@204457|Sphingomonadales	204457|Sphingomonadales	F	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL	purQ	-	6.3.5.3	ko:K01952	ko00230,ko01100,ko01110,ko01130,map00230,map01100,map01110,map01130	M00048	R04463	RC00010,RC01160	ko00000,ko00001,ko00002,ko01000	-	-	-	GATase_5
HKD2_k127_8968728_2	1112212.JH584235_gene3566	7.154e-125	403.0	COG1738@1|root,COG1738@2|Bacteria,1NIPE@1224|Proteobacteria,2TTZV@28211|Alphaproteobacteria,2K1FS@204457|Sphingomonadales	204457|Sphingomonadales	S	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage	-	-	-	ko:K09125	-	-	-	-	ko00000	-	-	-	Vut_1
HKD2_k127_8968728_1	1101189.AQUO01000002_gene728	1.171e-148	489.0	COG1961@1|root,COG1961@2|Bacteria,1PFVE@1224|Proteobacteria,2V7HD@28211|Alphaproteobacteria,2PYM2@265|Paracoccus	28211|Alphaproteobacteria	L	Recombinase zinc beta ribbon domain	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Zn_ribbon_recom
HKD2_k127_9020324_6	243233.MCA2283	1.353e-87	303.0	COG0439@1|root,COG0439@2|Bacteria,1NHC0@1224|Proteobacteria	1224|Proteobacteria	I	Biotin carboxylase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9020324_1	1449049.JONW01000005_gene1649	1.595e-215	689.0	COG3590@1|root,COG3590@2|Bacteria,1MVNQ@1224|Proteobacteria,2TRU4@28211|Alphaproteobacteria,2KEYS@204458|Caulobacterales	204458|Caulobacterales	O	peptidase M13	-	-	-	ko:K07386	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Peptidase_M13,Peptidase_M13_N
HKD2_k127_9020324_14	702113.PP1Y_AT8366	1.983e-40	153.0	COG3805@1|root,COG3805@2|Bacteria,1RIFS@1224|Proteobacteria,2VG1N@28211|Alphaproteobacteria	28211|Alphaproteobacteria	Q	Dopa 4,5-dioxygenase family	-	-	-	ko:K10253	-	-	-	-	ko00000,ko01000	-	-	-	DOPA_dioxygen
HKD2_k127_9020324_18	1122604.JONR01000039_gene3784	3.043e-27	115.0	28ZXZ@1|root,2ZMNF@2|Bacteria,1NM5Z@1224|Proteobacteria	1224|Proteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9020324_10	1122604.JONR01000039_gene3785	4.949e-69	239.0	COG1695@1|root,COG1695@2|Bacteria,1NKS4@1224|Proteobacteria	1224|Proteobacteria	K	Transcriptional regulator PadR-like family	-	-	-	-	-	-	-	-	-	-	-	-	PadR
HKD2_k127_9020324_2	1123267.JONN01000002_gene272	3.002e-150	479.0	COG0115@1|root,COG0115@2|Bacteria,1MVB0@1224|Proteobacteria,2TR1H@28211|Alphaproteobacteria,2K0G3@204457|Sphingomonadales	204457|Sphingomonadales	E	Branched-chain amino acid aminotransferase	ilvE	-	2.6.1.42	ko:K00826	ko00270,ko00280,ko00290,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00270,map00280,map00290,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00036,M00119,M00570	R01090,R01214,R02199,R10991	RC00006,RC00036	ko00000,ko00001,ko00002,ko01000,ko01007	-	-	-	Aminotran_4
HKD2_k127_9020324_12	1123267.JONN01000002_gene271	2.09e-64	235.0	COG0345@1|root,COG0345@2|Bacteria,1R5J1@1224|Proteobacteria,2TTY7@28211|Alphaproteobacteria,2K353@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline	proC	-	1.5.1.2	ko:K00286	ko00330,ko01100,ko01110,ko01130,ko01230,map00330,map01100,map01110,map01130,map01230	M00015	R01248,R01251,R03291,R03293	RC00054,RC00083	ko00000,ko00001,ko00002,ko01000	-	-	-	F420_oxidored,P5CR_dimer
HKD2_k127_9020324_8	1123267.JONN01000002_gene270	1.658e-82	278.0	COG5465@1|root,COG5465@2|Bacteria,1REC1@1224|Proteobacteria,2U7UP@28211|Alphaproteobacteria,2K1T3@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative bacterial sensory transduction regulator	-	-	-	-	-	-	-	-	-	-	-	-	YbjN
HKD2_k127_9020324_15	1550073.JROH01000012_gene2552	3.768e-31	126.0	COG2960@1|root,COG2960@2|Bacteria,1N725@1224|Proteobacteria,2UFEP@28211|Alphaproteobacteria,2K74V@204457|Sphingomonadales	204457|Sphingomonadales	S	Membrane fusogenic activity	-	-	-	ko:K09806	-	-	-	-	ko00000	-	-	-	BMFP
HKD2_k127_9020324_13	1219045.BV98_000237	1.753e-40	162.0	COG3476@1|root,COG3476@2|Bacteria,1MZC1@1224|Proteobacteria,2UBYB@28211|Alphaproteobacteria,2K4UV@204457|Sphingomonadales	204457|Sphingomonadales	T	Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)	bzrP	-	-	ko:K05770	ko04080,ko04214,ko04979,ko05166,map04080,map04214,map04979,map05166	-	-	-	ko00000,ko00001,ko02000	9.A.24	-	-	TspO_MBR
HKD2_k127_9020324_4	1248916.ANFY01000017_gene1543	3.773e-115	378.0	COG1189@1|root,COG1189@2|Bacteria,1MWP5@1224|Proteobacteria,2TRW9@28211|Alphaproteobacteria,2K0J2@204457|Sphingomonadales	204457|Sphingomonadales	J	Hemolysin	-	-	2.1.1.226,2.1.1.227	ko:K06442	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	FtsJ,S4
HKD2_k127_9020324_22	1121097.JCM15093_3046	1.691e-12	73.0	COG0818@1|root,COG0818@2|Bacteria,4NQ39@976|Bacteroidetes,2FSJ8@200643|Bacteroidia,4AQWN@815|Bacteroidaceae	976|Bacteroidetes	M	Psort location CytoplasmicMembrane, score	dgkA	-	2.7.1.107,2.7.1.66	ko:K00887,ko:K00901	ko00550,ko00561,ko00564,ko01100,ko01110,ko04070,ko04072,ko05231,map00550,map00561,map00564,map01100,map01110,map04070,map04072,map05231	-	R02240,R05626	RC00002,RC00017	ko00000,ko00001,ko01000	-	-	-	DAGK_prokar
HKD2_k127_9020324_0	1123267.JONN01000002_gene265	0.0	1030.0	COG1154@1|root,COG1154@2|Bacteria,1MUSJ@1224|Proteobacteria,2TRDD@28211|Alphaproteobacteria,2K0XY@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)	dxs	-	2.2.1.7	ko:K01662	ko00730,ko00900,ko01100,ko01110,ko01130,map00730,map00900,map01100,map01110,map01130	M00096	R05636	RC00032	ko00000,ko00001,ko00002,ko01000	-	-	-	DXP_synthase_N,Transket_pyr,Transketolase_C
HKD2_k127_9020324_11	1123267.JONN01000002_gene262	1.368e-66	232.0	COG0735@1|root,COG0735@2|Bacteria,1MZIW@1224|Proteobacteria,2U9G4@28211|Alphaproteobacteria,2K4GM@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the Fur family	-	-	-	ko:K09823	ko02024,map02024	-	-	-	ko00000,ko00001,ko03000	-	-	-	FUR
HKD2_k127_9020324_16	1123267.JONN01000002_gene260	1.774e-30	124.0	2E2R2@1|root,32XTN@2|Bacteria,1NHQU@1224|Proteobacteria,2TVUG@28211|Alphaproteobacteria,2KE8A@204457|Sphingomonadales	204457|Sphingomonadales	S	MerC mercury resistance protein	-	-	-	-	-	-	-	-	-	-	-	-	MerC
HKD2_k127_9020324_3	1123270.ATUR01000004_gene1710	6.311e-132	430.0	COG1612@1|root,COG1612@2|Bacteria,1MVJ4@1224|Proteobacteria,2TR0M@28211|Alphaproteobacteria,2K0QN@204457|Sphingomonadales	204457|Sphingomonadales	O	Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group	ctaA	-	-	ko:K02259	ko00190,ko00860,ko01100,ko01110,ko02020,ko04714,map00190,map00860,map01100,map01110,map02020,map04714	M00154	R07412	RC00769	ko00000,ko00001,ko00002,ko03029	3.D.4.4	-	-	COX15-CtaA
HKD2_k127_9020324_19	745310.G432_13995	2.49e-23	106.0	COG1324@1|root,COG1324@2|Bacteria,1N6TN@1224|Proteobacteria,2UF5Y@28211|Alphaproteobacteria,2K75D@204457|Sphingomonadales	204457|Sphingomonadales	P	CutA1 divalent ion tolerance protein	-	-	-	ko:K03926	-	-	-	-	ko00000	-	-	-	CutA1
HKD2_k127_9020324_9	1123267.JONN01000001_gene749	2.75e-78	268.0	COG0664@1|root,COG0664@2|Bacteria,1RA0S@1224|Proteobacteria,2U65I@28211|Alphaproteobacteria,2KCW3@204457|Sphingomonadales	204457|Sphingomonadales	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_9020324_7	426117.M446_2906	2.11e-84	297.0	COG3025@1|root,COG5607@1|root,COG3025@2|Bacteria,COG5607@2|Bacteria,1MY43@1224|Proteobacteria,2TQRV@28211|Alphaproteobacteria,1JTYK@119045|Methylobacteriaceae	28211|Alphaproteobacteria	S	PFAM CHAD domain containing protein	-	-	-	-	-	-	-	-	-	-	-	-	CHAD,CYTH
HKD2_k127_9020324_17	1122214.AQWH01000014_gene3562	1.336e-28	121.0	COG0494@1|root,COG0494@2|Bacteria,1MZ5D@1224|Proteobacteria,2UBX9@28211|Alphaproteobacteria,2PJZZ@255475|Aurantimonadaceae	28211|Alphaproteobacteria	L	NUDIX domain	-	-	-	-	-	-	-	-	-	-	-	-	NUDIX
HKD2_k127_9020324_21	1112214.AHIS01000098_gene1439	1.436e-14	82.0	2AGMS@1|root,316V2@2|Bacteria,1P0WN@1224|Proteobacteria,2UV7D@28211|Alphaproteobacteria,2K700@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9020324_5	1089551.KE386572_gene4603	9.258e-89	299.0	COG0664@1|root,COG0664@2|Bacteria,1PHAF@1224|Proteobacteria,2V8J8@28211|Alphaproteobacteria,4BSFV@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	T	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_9050156_0	1123267.JONN01000001_gene1626	0.0	1796.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD2_k127_9050156_3	1081640.AGFU01000021_gene1978	1.427e-81	281.0	COG0596@1|root,COG0596@2|Bacteria,1MVVX@1224|Proteobacteria,2TT0S@28211|Alphaproteobacteria,2K14Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6
HKD2_k127_9050156_1	717785.HYPMC_3977	2.573e-209	662.0	COG5361@1|root,COG5361@2|Bacteria,1MWTW@1224|Proteobacteria,2TUR1@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1254)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1214,DUF1254
HKD2_k127_9050156_6	234267.Acid_5415	1.945e-16	82.0	2ECC0@1|root,336AD@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9050156_4	1123267.JONN01000001_gene1623	2.488e-58	205.0	COG0222@1|root,COG0222@2|Bacteria,1RGU4@1224|Proteobacteria,2U9FX@28211|Alphaproteobacteria,2K4H8@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation	rplL	-	-	ko:K02935	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L12,Ribosomal_L12_N
HKD2_k127_9050156_2	1123267.JONN01000001_gene1622	5.303e-87	294.0	COG0244@1|root,COG0244@2|Bacteria,1RAN5@1224|Proteobacteria,2U592@28211|Alphaproteobacteria,2K3XB@204457|Sphingomonadales	204457|Sphingomonadales	J	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors	rplJ	-	-	ko:K02864	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_L10
HKD2_k127_9050156_5	1123267.JONN01000001_gene1703	1.329e-54	197.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria,2K90M@204457|Sphingomonadales	204457|Sphingomonadales	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_9081658_1	477641.MODMU_1794	2.405e-147	482.0	COG1073@1|root,COG2114@1|root,COG1073@2|Bacteria,COG2114@2|Bacteria,2IASU@201174|Actinobacteria	201174|Actinobacteria	IT	Pfam Adenylate and Guanylate cyclase catalytic domain	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Guanylate_cyc
HKD2_k127_9081658_2	365044.Pnap_4542	8.235e-38	150.0	2C6BU@1|root,32S87@2|Bacteria,1NIFE@1224|Proteobacteria,2VRGB@28216|Betaproteobacteria,4AGT5@80864|Comamonadaceae	28216|Betaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9081658_0	1380355.JNIJ01000037_gene5325	6.806e-174	555.0	COG0604@1|root,COG0604@2|Bacteria,1MXRA@1224|Proteobacteria,2U144@28211|Alphaproteobacteria,3JV4Z@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N,ADH_zinc_N_2
HKD2_k127_9081658_3	366602.Caul_3172	2.162e-37	144.0	COG3631@1|root,COG3631@2|Bacteria,1N487@1224|Proteobacteria,2UDWM@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	SnoaL-like domain	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL_2
HKD2_k127_9100247_2	743299.Acife_0127	7.313e-27	112.0	COG2944@1|root,COG2944@2|Bacteria,1MZGM@1224|Proteobacteria,1S97H@1236|Gammaproteobacteria,2NDWY@225057|Acidithiobacillales	225057|Acidithiobacillales	K	Helix-turn-helix XRE-family like proteins	-	-	-	ko:K07726	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HKD2_k127_9100247_1	1280954.HPO_03404	1.063e-58	216.0	COG5397@1|root,COG5397@2|Bacteria,1R4MR@1224|Proteobacteria,2U2XQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleotidyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_8
HKD2_k127_9100247_0	62928.azo1497	2.916e-101	335.0	COG1186@1|root,COG1186@2|Bacteria,1MUAW@1224|Proteobacteria,2VJ6C@28216|Betaproteobacteria,2KUA1@206389|Rhodocyclales	206389|Rhodocyclales	J	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA	prfB	-	-	ko:K02836	-	-	-	-	ko00000,ko03012	-	-	-	PCRF,RF-1
HKD2_k127_9105573_0	398525.KB900701_gene1229	3.816e-118	384.0	COG0410@1|root,COG0410@2|Bacteria,1MUR3@1224|Proteobacteria,2TSWQ@28211|Alphaproteobacteria,3JRHZ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	E	ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_9105573_1	883080.HMPREF9697_03401	3.372e-84	281.0	COG0411@1|root,COG4177@1|root,COG0411@2|Bacteria,COG4177@2|Bacteria,1MUTY@1224|Proteobacteria,2TQVU@28211|Alphaproteobacteria,3JRTU@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	P	Belongs to the binding-protein-dependent transport system permease family	-	-	-	ko:K01995,ko:K01998	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran,BCA_ABC_TP_C,BPD_transp_2
HKD2_k127_9151697_18	1219035.NT2_05_00020	2.832e-260	823.0	COG0457@1|root,COG0457@2|Bacteria,1MVMG@1224|Proteobacteria,2TSGE@28211|Alphaproteobacteria,2K04M@204457|Sphingomonadales	204457|Sphingomonadales	S	Sulfotransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Sulfotransfer_3,TPR_16,TPR_2,TPR_8
HKD2_k127_9151697_35	1408419.JHYG01000010_gene2422	1.528e-161	512.0	COG0175@1|root,COG0175@2|Bacteria,1MUCZ@1224|Proteobacteria,2TT2D@28211|Alphaproteobacteria,2JQKR@204441|Rhodospirillales	204441|Rhodospirillales	EH	COG0175 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase) FAD synthetase and related enzymes	cysD	-	2.7.7.4	ko:K00957	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00529,R04929	RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	PAPS_reduct
HKD2_k127_9151697_11	627192.SLG_22430	9.243e-310	961.0	COG0529@1|root,COG2895@1|root,COG0529@2|Bacteria,COG2895@2|Bacteria,1MUD9@1224|Proteobacteria,2TQNJ@28211|Alphaproteobacteria,2K22T@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN NodQ subfamily	cysC	-	2.7.1.25,2.7.7.4	ko:K00955,ko:K00956	ko00230,ko00261,ko00450,ko00920,ko01100,ko01120,ko01130,map00230,map00261,map00450,map00920,map01100,map01120,map01130	M00176,M00596	R00509,R00529,R04928,R04929	RC00002,RC00078,RC02809,RC02889	ko00000,ko00001,ko00002,ko01000	-	-	-	APS_kinase,GTP_EFTU,GTP_EFTU_D2
HKD2_k127_9151697_69	1123267.JONN01000001_gene2082	1.574e-89	302.0	COG3713@1|root,COG3713@2|Bacteria,1REKJ@1224|Proteobacteria,2U37S@28211|Alphaproteobacteria,2K45C@204457|Sphingomonadales	204457|Sphingomonadales	M	MltA-interacting protein MipA	-	-	-	-	-	-	-	-	-	-	-	-	MipA
HKD2_k127_9151697_89	745310.G432_14530	2.794e-66	226.0	COG1146@1|root,COG1146@2|Bacteria,1RH5I@1224|Proteobacteria,2U98K@28211|Alphaproteobacteria,2K4E8@204457|Sphingomonadales	204457|Sphingomonadales	C	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions	-	-	-	ko:K05524	-	-	-	-	ko00000	-	-	-	DUF3470,Fer4
HKD2_k127_9151697_115	1123267.JONN01000001_gene2080	1.796e-25	115.0	COG1188@1|root,COG1188@2|Bacteria,1MZR6@1224|Proteobacteria,2UBS3@28211|Alphaproteobacteria,2K6XI@204457|Sphingomonadales	204457|Sphingomonadales	J	COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog)	hslR	-	-	ko:K04762	-	-	-	-	ko00000,ko03110	-	-	-	S4
HKD2_k127_9151697_4	1123267.JONN01000001_gene2079	0.0	1196.0	COG4581@1|root,COG4581@2|Bacteria,1MVD6@1224|Proteobacteria,2TR7N@28211|Alphaproteobacteria,2JZXM@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	-	-	3.6.4.13	ko:K17675	-	-	-	-	ko00000,ko01000,ko03029	-	-	-	Helicase_C
HKD2_k127_9151697_76	1123267.JONN01000001_gene2078	5.337e-80	282.0	COG0739@1|root,COG0739@2|Bacteria,1MVTF@1224|Proteobacteria,2TT3Z@28211|Alphaproteobacteria,2K2A0@204457|Sphingomonadales	204457|Sphingomonadales	M	membrane	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M23
HKD2_k127_9151697_68	1449076.JOOE01000001_gene2200	7.487e-90	306.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	YkuD
HKD2_k127_9151697_125	794846.AJQU01000076_gene241	5.184e-14	76.0	2EEKZ@1|root,338ET@2|Bacteria,1NCM1@1224|Proteobacteria,2UFHE@28211|Alphaproteobacteria,4BF3M@82115|Rhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_12	1123267.JONN01000001_gene2075	1.07e-296	917.0	COG0433@1|root,COG0433@2|Bacteria,1MUSH@1224|Proteobacteria,2TUN9@28211|Alphaproteobacteria,2K091@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function DUF87	-	-	-	ko:K06915	-	-	-	-	ko00000	-	-	-	DUF853,DUF87
HKD2_k127_9151697_58	1123267.JONN01000001_gene2074	3.37e-106	365.0	2AFUA@1|root,315WQ@2|Bacteria,1NHGB@1224|Proteobacteria,2TQWW@28211|Alphaproteobacteria,2JZXR@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative transmembrane protein (Alph_Pro_TM)	-	-	-	-	-	-	-	-	-	-	-	-	Alph_Pro_TM
HKD2_k127_9151697_44	1123267.JONN01000001_gene2073	4.476e-133	430.0	COG0730@1|root,COG0730@2|Bacteria,1MWX2@1224|Proteobacteria,2TRIC@28211|Alphaproteobacteria,2K1QQ@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9151697_111	1123267.JONN01000001_gene1913	8.172e-30	124.0	COG5342@1|root,COG5342@2|Bacteria,1NVB8@1224|Proteobacteria,2UAQU@28211|Alphaproteobacteria,2K5ZJ@204457|Sphingomonadales	204457|Sphingomonadales	S	invasion associated locus B	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_24	1123267.JONN01000001_gene1912	2.077e-222	692.0	COG0820@1|root,COG0820@2|Bacteria,1MUYK@1224|Proteobacteria,2TQT3@28211|Alphaproteobacteria,2K0CT@204457|Sphingomonadales	204457|Sphingomonadales	J	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs	rlmN	-	2.1.1.192	ko:K06941	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	Radical_SAM
HKD2_k127_9151697_60	452662.SJA_C2-00390	2.724e-100	334.0	COG3662@1|root,COG3662@2|Bacteria,1R50Q@1224|Proteobacteria,2TSG5@28211|Alphaproteobacteria,2K0BR@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF2236
HKD2_k127_9151697_37	1123267.JONN01000001_gene1910	1.978e-154	498.0	COG2230@1|root,COG2230@2|Bacteria,1MX3U@1224|Proteobacteria,2TR8K@28211|Alphaproteobacteria,2K0PR@204457|Sphingomonadales	204457|Sphingomonadales	M	synthase	-	-	2.1.1.79	ko:K00574	-	-	-	-	ko00000,ko01000	-	-	-	CMAS
HKD2_k127_9151697_118	745310.G432_09575	5.33e-20	99.0	COG5126@1|root,COG5126@2|Bacteria,1NH5D@1224|Proteobacteria,2UJHN@28211|Alphaproteobacteria,2K61Q@204457|Sphingomonadales	204457|Sphingomonadales	DTZ	EF-hand, calcium binding motif	-	-	-	-	-	-	-	-	-	-	-	-	EF-hand_5
HKD2_k127_9151697_17	46429.BV95_02768	8.225e-270	837.0	COG1232@1|root,COG1232@2|Bacteria,1MX35@1224|Proteobacteria,2TU7I@28211|Alphaproteobacteria,2K14D@204457|Sphingomonadales	204457|Sphingomonadales	H	Thi4 family	-	-	-	-	-	-	-	-	-	-	-	-	Amino_oxidase,NAD_binding_8
HKD2_k127_9151697_112	1044.EH31_15755	5.496e-29	121.0	COG2246@1|root,COG2246@2|Bacteria,1N1WS@1224|Proteobacteria,2UDTY@28211|Alphaproteobacteria,2K662@204457|Sphingomonadales	204457|Sphingomonadales	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD2_k127_9151697_52	1090318.ATTI01000001_gene3296	3.631e-118	405.0	COG1287@1|root,COG1287@2|Bacteria,1RCIB@1224|Proteobacteria,2TV2J@28211|Alphaproteobacteria,2KDNP@204457|Sphingomonadales	204457|Sphingomonadales	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_31	1123267.JONN01000001_gene1908	1.076e-176	567.0	COG4993@1|root,COG4993@2|Bacteria,1N7DU@1224|Proteobacteria,2U6Z1@28211|Alphaproteobacteria,2K133@204457|Sphingomonadales	204457|Sphingomonadales	G	Dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_36	1123267.JONN01000001_gene1907	7.811e-157	501.0	COG0463@1|root,COG0463@2|Bacteria,1MWE5@1224|Proteobacteria,2TRRT@28211|Alphaproteobacteria,2K121@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyl transferase family 2	-	-	-	ko:K20534	-	-	-	-	ko00000,ko01000,ko01005,ko02000	4.D.2.1.9	GT2	-	Glycos_transf_2
HKD2_k127_9151697_110	696281.Desru_2828	2.783e-30	133.0	COG0500@1|root,COG0500@2|Bacteria,1VJS9@1239|Firmicutes,24TBM@186801|Clostridia	186801|Clostridia	Q	PFAM Methyltransferase type 11	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11
HKD2_k127_9151697_102	1081640.AGFU01000055_gene157	1.163e-44	166.0	COG2246@1|root,COG2246@2|Bacteria,1N67P@1224|Proteobacteria,2UDG8@28211|Alphaproteobacteria,2KE35@204457|Sphingomonadales	204457|Sphingomonadales	S	GtrA-like protein	-	-	-	-	-	-	-	-	-	-	-	-	GtrA
HKD2_k127_9151697_26	1123267.JONN01000001_gene1904	3.943e-212	676.0	COG1287@1|root,COG1287@2|Bacteria,1RCIB@1224|Proteobacteria,2U677@28211|Alphaproteobacteria,2K1YU@204457|Sphingomonadales	204457|Sphingomonadales	S	oligosaccharyl transferase activity	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_81	1123267.JONN01000001_gene1903	3.083e-75	262.0	COG2095@1|root,COG2095@2|Bacteria,1MX5T@1224|Proteobacteria,2U59A@28211|Alphaproteobacteria,2K0G8@204457|Sphingomonadales	204457|Sphingomonadales	U	UPF0056 membrane protein	-	-	-	ko:K05595	-	-	-	-	ko00000,ko02000	2.A.95.1	-	-	MarC
HKD2_k127_9151697_98	1123267.JONN01000001_gene1902	3.795e-49	182.0	2ANEF@1|root,31DD2@2|Bacteria,1RHST@1224|Proteobacteria,2UA6U@28211|Alphaproteobacteria,2K5G6@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_45	745310.G432_08255	8.511e-133	434.0	COG0190@1|root,COG0190@2|Bacteria,1MWU4@1224|Proteobacteria,2TRZZ@28211|Alphaproteobacteria,2K03K@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate	folD	-	1.5.1.5,3.5.4.9	ko:K01491	ko00670,ko00720,ko01100,ko01120,ko01200,map00670,map00720,map01100,map01120,map01200	M00140,M00377	R01220,R01655	RC00202,RC00578	ko00000,ko00001,ko00002,ko01000	-	-	-	THF_DHG_CYH,THF_DHG_CYH_C
HKD2_k127_9151697_116	1007104.SUS17_2028	1.814e-25	108.0	COG0762@1|root,COG0762@2|Bacteria,1N73Q@1224|Proteobacteria,2UFZR@28211|Alphaproteobacteria,2K6UW@204457|Sphingomonadales	204457|Sphingomonadales	S	integral membrane protein	-	-	-	ko:K02221	-	-	-	-	ko00000,ko02044	-	-	-	YGGT
HKD2_k127_9151697_49	1007104.SUS17_2371	9.515e-122	400.0	COG4301@1|root,COG4301@2|Bacteria,1MUCG@1224|Proteobacteria,2TRMH@28211|Alphaproteobacteria,2K0WW@204457|Sphingomonadales	204457|Sphingomonadales	S	Histidine-specific methyltransferase, SAM-dependent	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_33
HKD2_k127_9151697_32	1123267.JONN01000001_gene1898	3.474e-176	566.0	COG1262@1|root,COG1262@2|Bacteria,1MUNC@1224|Proteobacteria,2TQXE@28211|Alphaproteobacteria,2K0TI@204457|Sphingomonadales	204457|Sphingomonadales	S	DinB superfamily	-	-	-	-	-	-	-	-	-	-	-	-	DinB_2,FGE-sulfatase
HKD2_k127_9151697_88	1123267.JONN01000001_gene1896	4.506e-69	239.0	COG2096@1|root,COG2096@2|Bacteria,1RDUF@1224|Proteobacteria,2U5J1@28211|Alphaproteobacteria,2K3VX@204457|Sphingomonadales	204457|Sphingomonadales	S	adenosyltransferase	-	-	2.5.1.17	ko:K00798	ko00860,ko01100,map00860,map01100	M00122	R01492,R05220,R07268	RC00533	ko00000,ko00001,ko00002,ko01000	-	-	-	Cob_adeno_trans
HKD2_k127_9151697_59	1123267.JONN01000001_gene1894	3.372e-105	348.0	COG0008@1|root,COG0008@2|Bacteria,1MUN7@1224|Proteobacteria,2TR2V@28211|Alphaproteobacteria,2K0FZ@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	gluQ	-	-	ko:K01894	-	-	-	-	ko00000,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1c
HKD2_k127_9151697_56	1123267.JONN01000001_gene1893	2.62e-111	362.0	COG1403@1|root,COG1403@2|Bacteria,1MWEQ@1224|Proteobacteria,2TR3M@28211|Alphaproteobacteria,2K04Q@204457|Sphingomonadales	204457|Sphingomonadales	L	HNH endonuclease	-	-	-	-	-	-	-	-	-	-	-	-	HNH_5
HKD2_k127_9151697_46	1123267.JONN01000001_gene1891	2.257e-132	431.0	COG1210@1|root,COG1210@2|Bacteria,1MV5F@1224|Proteobacteria,2TRT6@28211|Alphaproteobacteria,2K1NI@204457|Sphingomonadales	204457|Sphingomonadales	M	UTP-glucose-1-phosphate uridylyltransferase	ugpG	-	2.7.7.9	ko:K00963	ko00040,ko00052,ko00500,ko00520,ko01100,ko01130,map00040,map00052,map00500,map00520,map01100,map01130	M00129,M00361,M00362,M00549	R00289	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	NTP_transferase
HKD2_k127_9151697_119	1123267.JONN01000001_gene1890	7.143e-20	92.0	293KA@1|root,2ZR29@2|Bacteria,1NKAC@1224|Proteobacteria,2UK1U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_107	161528.ED21_24081	3.417e-33	135.0	COG0526@1|root,COG0526@2|Bacteria,1MZ5J@1224|Proteobacteria,2TR0C@28211|Alphaproteobacteria,2K5QM@204457|Sphingomonadales	204457|Sphingomonadales	CO	Redoxin	-	-	-	-	-	-	-	-	-	-	-	-	AhpC-TSA,Redoxin
HKD2_k127_9151697_65	1123229.AUBC01000009_gene311	3.618e-92	313.0	COG0697@1|root,COG0697@2|Bacteria,1MZQM@1224|Proteobacteria,2TUPG@28211|Alphaproteobacteria,3JS7M@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	EG	EamA-like transporter family	-	-	-	-	-	-	-	-	-	-	-	-	EamA
HKD2_k127_9151697_0	1112216.JH594425_gene2026	0.0	1343.0	COG0726@1|root,COG1215@1|root,COG3858@1|root,COG0726@2|Bacteria,COG1215@2|Bacteria,COG3858@2|Bacteria,1MXG7@1224|Proteobacteria,2TVZ5@28211|Alphaproteobacteria,2K1ER@204457|Sphingomonadales	204457|Sphingomonadales	GM	Polysaccharide deacetylase	-	-	3.5.1.104	ko:K22278	-	-	-	-	ko00000,ko01000	-	-	-	Glyco_hydro_18,Glyco_tranf_2_3,Polysacc_deac_1
HKD2_k127_9151697_63	1112216.JH594425_gene3661	2.42e-94	326.0	2B90Y@1|root,322BP@2|Bacteria,1N0TB@1224|Proteobacteria,2UTZV@28211|Alphaproteobacteria,2K39H@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_42	1123267.JONN01000001_gene1886	9.448e-136	437.0	COG2171@1|root,COG2171@2|Bacteria,1MU0Y@1224|Proteobacteria,2TS3H@28211|Alphaproteobacteria,2K055@204457|Sphingomonadales	204457|Sphingomonadales	E	Belongs to the transferase hexapeptide repeat family	dapD	-	2.3.1.117	ko:K00674	ko00300,ko01100,ko01120,ko01230,map00300,map01100,map01120,map01230	M00016	R04365	RC00004,RC01136	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep,Hexapep_2,THDPS_N_2
HKD2_k127_9151697_61	1123267.JONN01000001_gene1885	4.59e-100	330.0	COG1011@1|root,COG1011@2|Bacteria,1PHPQ@1224|Proteobacteria,2TUDN@28211|Alphaproteobacteria,2KEBI@204457|Sphingomonadales	204457|Sphingomonadales	S	Hydrolase	-	-	-	ko:K07025	-	-	-	-	ko00000	-	-	-	HAD_2
HKD2_k127_9151697_21	1123267.JONN01000001_gene1884	1.592e-235	754.0	COG1404@1|root,COG1404@2|Bacteria,1MU3S@1224|Proteobacteria,2U0VY@28211|Alphaproteobacteria,2K0U8@204457|Sphingomonadales	204457|Sphingomonadales	O	Subtilase family	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S8
HKD2_k127_9151697_73	1120705.FG95_02690	6.387e-84	285.0	COG2020@1|root,COG2020@2|Bacteria,1MWU6@1224|Proteobacteria,2TU80@28211|Alphaproteobacteria	28211|Alphaproteobacteria	O	methyltransferase activity	-	-	2.1.1.334	ko:K21310	ko00920,map00920	-	R11546	RC02653	ko00000,ko00001,ko01000	-	-	-	NnrU,PEMT
HKD2_k127_9151697_90	1123267.JONN01000001_gene2063	6.598e-63	217.0	COG0316@1|root,COG0316@2|Bacteria,1RH6T@1224|Proteobacteria,2UBWJ@28211|Alphaproteobacteria,2K4FF@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the HesB IscA family	-	-	-	ko:K13628	-	-	-	-	ko00000,ko03016	-	-	-	Fe-S_biosyn
HKD2_k127_9151697_86	1123267.JONN01000001_gene2064	2.138e-69	241.0	COG2151@1|root,COG2151@2|Bacteria,1MZ9Y@1224|Proteobacteria,2U72U@28211|Alphaproteobacteria,2K4IC@204457|Sphingomonadales	204457|Sphingomonadales	S	FeS assembly SUF system protein	-	-	-	-	-	-	-	-	-	-	-	-	FeS_assembly_P
HKD2_k127_9151697_30	1123267.JONN01000001_gene2065	1.105e-186	590.0	COG0520@1|root,COG0520@2|Bacteria,1MUPD@1224|Proteobacteria,2TRNY@28211|Alphaproteobacteria,2JZVI@204457|Sphingomonadales	204457|Sphingomonadales	E	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine	sufS	-	2.8.1.7,4.4.1.16	ko:K11717	ko00450,ko01100,map00450,map01100	-	R03599,R11528	RC00961,RC01789,RC02313	ko00000,ko00001,ko01000	-	-	-	Aminotran_5
HKD2_k127_9151697_77	1123267.JONN01000001_gene2066	6.206e-80	273.0	COG0719@1|root,COG0719@2|Bacteria,1MVK0@1224|Proteobacteria,2TTK9@28211|Alphaproteobacteria,2K20T@204457|Sphingomonadales	204457|Sphingomonadales	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufD	-	-	ko:K09015	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_9151697_47	1123267.JONN01000001_gene2067	9.006e-126	409.0	COG0396@1|root,COG0396@2|Bacteria,1MUGK@1224|Proteobacteria,2TS8T@28211|Alphaproteobacteria,2K0E3@204457|Sphingomonadales	204457|Sphingomonadales	O	ABC-type transport system involved in Fe-S cluster assembly, ATPase component	sufC	-	-	ko:K09013	-	-	-	-	ko00000,ko02000	-	-	-	ABC_tran
HKD2_k127_9151697_14	1123267.JONN01000001_gene2069	9.605e-289	889.0	COG0719@1|root,COG0719@2|Bacteria,1MVKY@1224|Proteobacteria,2TRU6@28211|Alphaproteobacteria,2K196@204457|Sphingomonadales	204457|Sphingomonadales	O	ABC-type transport system involved in Fe-S cluster assembly, permease component	sufB	-	-	ko:K09014	-	-	-	-	ko00000	-	-	-	UPF0051
HKD2_k127_9151697_103	392499.Swit_2919	1.66e-42	159.0	COG1959@1|root,COG1959@2|Bacteria,1N0E2@1224|Proteobacteria,2UAVK@28211|Alphaproteobacteria,2K421@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	-	-	-	-	-	-	-	-	-	Rrf2
HKD2_k127_9151697_43	983920.Y88_2502	2.569e-135	441.0	COG0167@1|root,COG0167@2|Bacteria,1MU7C@1224|Proteobacteria,2TRF8@28211|Alphaproteobacteria,2K1QF@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor	pyrD	-	1.3.5.2	ko:K00254	ko00240,ko01100,map00240,map01100	M00051	R01868	RC00051	ko00000,ko00001,ko00002,ko01000	-	-	-	DHO_dh
HKD2_k127_9151697_20	627192.SLG_01570	1.189e-237	747.0	COG0405@1|root,COG0405@2|Bacteria,1MUV6@1224|Proteobacteria,2TR49@28211|Alphaproteobacteria,2K0PZ@204457|Sphingomonadales	204457|Sphingomonadales	E	gamma-glutamyltranspeptidase	-	-	2.3.2.2,3.4.19.13	ko:K00681	ko00430,ko00460,ko00480,ko01100,map00430,map00460,map00480,map01100	-	R00494,R01262,R01687,R03867,R03916,R03970,R03971,R04935	RC00064,RC00090,RC00096	ko00000,ko00001,ko01000,ko01002	-	-	-	G_glu_transpept
HKD2_k127_9151697_16	1123267.JONN01000001_gene1917	1.642e-276	861.0	COG1022@1|root,COG1022@2|Bacteria,1MU4D@1224|Proteobacteria,2TSSI@28211|Alphaproteobacteria,2K12J@204457|Sphingomonadales	204457|Sphingomonadales	I	synthetase	-	-	6.2.1.3	ko:K01897	ko00061,ko00071,ko01100,ko01212,ko02024,ko03320,ko04146,ko04216,ko04714,ko04920,map00061,map00071,map01100,map01212,map02024,map03320,map04146,map04216,map04714,map04920	M00086	R01280	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000,ko01004,ko04147	4.C.1.1	-	-	AMP-binding
HKD2_k127_9151697_126	1123267.JONN01000001_gene1918	3.619e-12	73.0	2FB68@1|root,30QV6@2|Bacteria,1NWWK@1224|Proteobacteria,2US5H@28211|Alphaproteobacteria,2K6YE@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_70	194867.ALBQ01000028_gene2373	1.085e-86	293.0	COG0491@1|root,COG0491@2|Bacteria,1MU8Q@1224|Proteobacteria,2TSVS@28211|Alphaproteobacteria,2K0DY@204457|Sphingomonadales	204457|Sphingomonadales	S	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	gloB	-	3.1.2.6	ko:K01069	ko00620,map00620	-	R01736	RC00004,RC00137	ko00000,ko00001,ko01000	-	-	-	HAGH_C,Lactamase_B
HKD2_k127_9151697_55	745310.G432_11245	7.733e-112	372.0	COG2070@1|root,COG2070@2|Bacteria,1MU2F@1224|Proteobacteria,2TUT7@28211|Alphaproteobacteria,2K14V@204457|Sphingomonadales	204457|Sphingomonadales	S	2-nitropropane dioxygenase	-	-	1.13.12.16	ko:K00459	ko00910,map00910	-	R00025	RC02541,RC02759	ko00000,ko00001,ko01000	-	-	-	NMO
HKD2_k127_9151697_83	1123267.JONN01000001_gene1920	5.23e-73	247.0	COG0346@1|root,COG0346@2|Bacteria,1RCYX@1224|Proteobacteria,2U7A8@28211|Alphaproteobacteria,2K4E9@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0346 Lactoylglutathione lyase and related lyases	gloA	-	4.4.1.5	ko:K01759	ko00620,map00620	-	R02530	RC00004,RC00740	ko00000,ko00001,ko01000	-	-	-	Glyoxalase
HKD2_k127_9151697_67	685035.ADAE01000018_gene694	6.059e-90	302.0	COG2859@1|root,COG2859@2|Bacteria,1QU0K@1224|Proteobacteria,2U5D2@28211|Alphaproteobacteria,2K0TS@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF541)	-	-	-	ko:K09797	-	-	-	-	ko00000	-	-	-	SIMPL
HKD2_k127_9151697_117	745310.G432_10595	2.127e-24	112.0	COG0457@1|root,COG0457@2|Bacteria,1MYZ1@1224|Proteobacteria,2UCPV@28211|Alphaproteobacteria,2K4IW@204457|Sphingomonadales	204457|Sphingomonadales	S	Tetratricopeptide repeat	-	-	-	-	-	-	-	-	-	-	-	-	TPR_16,TPR_19,TPR_8
HKD2_k127_9151697_80	13689.BV96_02173	1.219e-75	260.0	COG1073@1|root,COG1073@2|Bacteria,1MX88@1224|Proteobacteria,2TSRE@28211|Alphaproteobacteria,2K1F6@204457|Sphingomonadales	204457|Sphingomonadales	S	Alpha beta hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Abhydrolase_6,Hydrolase_4
HKD2_k127_9151697_39	1123267.JONN01000001_gene638	1.13e-147	474.0	COG0667@1|root,COG0667@2|Bacteria,1MV2Y@1224|Proteobacteria,2TS02@28211|Alphaproteobacteria,2K1KY@204457|Sphingomonadales	204457|Sphingomonadales	C	aldo keto reductase	-	-	-	-	-	-	-	-	-	-	-	-	Aldo_ket_red
HKD2_k127_9151697_93	492774.JQMB01000007_gene4151	7.097e-54	201.0	2DVR0@1|root,33WUQ@2|Bacteria,1N2BP@1224|Proteobacteria,2UF1S@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_114	1112212.JH584235_gene3156	9.897e-26	108.0	COG1476@1|root,COG1476@2|Bacteria,1N6SS@1224|Proteobacteria,2UFFG@28211|Alphaproteobacteria,2K6RT@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K07729	-	-	-	-	ko00000,ko03000	-	-	-	HTH_3
HKD2_k127_9151697_75	113395.AXAI01000002_gene5399	2.06e-82	279.0	COG2020@1|root,COG2020@2|Bacteria,1R7G6@1224|Proteobacteria,2VG1Y@28211|Alphaproteobacteria,3K6HR@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Isoprenylcysteine carboxyl methyltransferase (ICMT) family	-	-	-	-	-	-	-	-	-	-	-	-	ICMT,PEMT
HKD2_k127_9151697_7	1234595.C725_0911	0.0	1119.0	COG0441@1|root,COG0441@2|Bacteria,1MUP2@1224|Proteobacteria,2TQWI@28211|Alphaproteobacteria,4BPFD@82117|unclassified Alphaproteobacteria	28211|Alphaproteobacteria	J	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)	thrS	-	6.1.1.3	ko:K01868	ko00970,map00970	M00359,M00360	R03663	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,TGS,tRNA-synt_2b,tRNA_SAD
HKD2_k127_9151697_66	1123267.JONN01000001_gene2054	2.281e-90	301.0	COG0290@1|root,COG0290@2|Bacteria,1RDD2@1224|Proteobacteria,2U58Z@28211|Alphaproteobacteria,2K0EN@204457|Sphingomonadales	204457|Sphingomonadales	J	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins	infC	-	-	ko:K02520	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	IF3_C,IF3_N
HKD2_k127_9151697_9	1123267.JONN01000001_gene2053	0.0	1035.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MWKN@1224|Proteobacteria,2TTI2@28211|Alphaproteobacteria,2K0SD@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_9151697_8	1123267.JONN01000001_gene2052	0.0	1073.0	COG2844@1|root,COG2844@2|Bacteria,1MV54@1224|Proteobacteria,2TSV0@28211|Alphaproteobacteria,2K0BN@204457|Sphingomonadales	204457|Sphingomonadales	O	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen	glnD	-	2.7.7.59	ko:K00990	ko02020,map02020	-	-	-	ko00000,ko00001,ko01000	-	-	-	DUF294,GlnD_UR_UTase,HD
HKD2_k127_9151697_2	1123267.JONN01000001_gene2051	0.0	1212.0	COG0249@1|root,COG0249@2|Bacteria,1MUGX@1224|Proteobacteria,2TQRR@28211|Alphaproteobacteria,2K09S@204457|Sphingomonadales	204457|Sphingomonadales	L	that it carries out the mismatch recognition step. This protein has a weak ATPase activity	mutS	-	-	ko:K03555	ko03430,map03430	-	-	-	ko00000,ko00001,ko03400	-	-	-	MutS_I,MutS_II,MutS_III,MutS_IV,MutS_V
HKD2_k127_9151697_5	1123267.JONN01000001_gene2050	0.0	1191.0	COG0280@1|root,COG0281@1|root,COG0280@2|Bacteria,COG0281@2|Bacteria,1MU0A@1224|Proteobacteria,2TQJT@28211|Alphaproteobacteria,2JZY4@204457|Sphingomonadales	204457|Sphingomonadales	C	Malic enzyme	maeB	-	1.1.1.40	ko:K00029	ko00620,ko00710,ko01100,ko01120,ko01200,map00620,map00710,map01100,map01120,map01200	M00169,M00172	R00216	RC00105	ko00000,ko00001,ko00002,ko01000	-	-	-	Malic_M,PTA_PTB,malic
HKD2_k127_9151697_3	1123267.JONN01000001_gene2049	0.0	1209.0	COG0317@1|root,COG0317@2|Bacteria,1MU44@1224|Proteobacteria,2TQNY@28211|Alphaproteobacteria,2K15Q@204457|Sphingomonadales	204457|Sphingomonadales	KT	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance	-	-	2.7.6.5,3.1.7.2	ko:K00951,ko:K01139	ko00230,map00230	-	R00336,R00429	RC00002,RC00078	ko00000,ko00001,ko01000,ko03009	-	-	-	ACT_4,HD_4,RelA_SpoT,TGS
HKD2_k127_9151697_127	1120705.FG95_00138	5.037e-12	70.0	2EG1C@1|root,339TC@2|Bacteria,1NGB5@1224|Proteobacteria,2UK68@28211|Alphaproteobacteria,2K7K2@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_97	1123267.JONN01000001_gene2048	2.4e-50	185.0	COG1733@1|root,COG1733@2|Bacteria,1RIZT@1224|Proteobacteria,2U7SS@28211|Alphaproteobacteria,2K4MD@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	HxlR
HKD2_k127_9151697_101	392499.Swit_2129	1.745e-45	168.0	2EBAW@1|root,335BJ@2|Bacteria,1N90V@1224|Proteobacteria,2UIYS@28211|Alphaproteobacteria,2K4JF@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF5051
HKD2_k127_9151697_27	1123267.JONN01000001_gene2426	2.324e-199	633.0	COG0624@1|root,COG0624@2|Bacteria,1MW20@1224|Proteobacteria,2TQY4@28211|Alphaproteobacteria,2K117@204457|Sphingomonadales	204457|Sphingomonadales	E	Peptidase dimerisation domain	-	-	-	-	-	-	-	-	-	-	-	-	M20_dimer,Peptidase_M20
HKD2_k127_9151697_121	1123267.JONN01000001_gene2427	2.792e-18	87.0	2DCTG@1|root,2ZF9T@2|Bacteria,1N82Z@1224|Proteobacteria,2UGXI@28211|Alphaproteobacteria,2K6Y3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_1	1123267.JONN01000001_gene2428	0.0	1212.0	COG1201@1|root,COG1201@2|Bacteria,1MUSW@1224|Proteobacteria,2TR7V@28211|Alphaproteobacteria,2K0I6@204457|Sphingomonadales	204457|Sphingomonadales	L	helicase	lhr	-	-	ko:K03724	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	DEAD,DEAD_assoc,Helicase_C
HKD2_k127_9151697_33	1219049.SP5_051_00080	9.991e-170	537.0	COG1236@1|root,COG1236@2|Bacteria,1MV7U@1224|Proteobacteria,2TQU5@28211|Alphaproteobacteria,2K1G9@204457|Sphingomonadales	204457|Sphingomonadales	J	exonuclease of the beta-lactamase fold involved in RNA processing	-	-	-	ko:K07577	-	-	-	-	ko00000	-	-	-	Lactamase_B
HKD2_k127_9151697_91	235985.BBPN01000026_gene1460	1.292e-58	215.0	COG2203@1|root,COG2208@1|root,COG2203@2|Bacteria,COG2208@2|Bacteria,2I9ID@201174|Actinobacteria,2NGFK@228398|Streptacidiphilus	201174|Actinobacteria	T	PAS fold	-	-	-	-	-	-	-	-	-	-	-	-	GAF_2,PAS_4,SpoIIE
HKD2_k127_9151697_106	1144307.PMI04_02257	2.878e-38	153.0	2C38E@1|root,33Z2K@2|Bacteria,1MY9G@1224|Proteobacteria,2U9BB@28211|Alphaproteobacteria,2K4JR@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_129	745310.G432_03760	6.666e-06	57.0	COG2885@1|root,COG2885@2|Bacteria,1R5IS@1224|Proteobacteria,2U2V8@28211|Alphaproteobacteria,2K1H8@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	-	-	-	-	-	-	-	-	-	-	-	-	OmpA
HKD2_k127_9151697_22	1123267.JONN01000001_gene2459	3.158e-231	722.0	COG1109@1|root,COG1109@2|Bacteria,1MUA5@1224|Proteobacteria,2TRIJ@28211|Alphaproteobacteria,2K0Q1@204457|Sphingomonadales	204457|Sphingomonadales	G	phosphomannomutase	-	-	5.4.2.8	ko:K01840	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01818	RC00408	ko00000,ko00001,ko00002,ko01000	-	-	-	PGM_PMM_I,PGM_PMM_II,PGM_PMM_III,PGM_PMM_IV
HKD2_k127_9151697_50	1123267.JONN01000001_gene2458	1.116e-121	405.0	COG1192@1|root,COG1192@2|Bacteria,1MVKR@1224|Proteobacteria,2TRZY@28211|Alphaproteobacteria,2K06A@204457|Sphingomonadales	204457|Sphingomonadales	D	involved in chromosome partitioning	-	-	-	ko:K03496	-	-	-	-	ko00000,ko03036,ko04812	-	-	-	MipZ
HKD2_k127_9151697_64	745310.G432_11140	1.14e-92	325.0	COG0414@1|root,COG0414@2|Bacteria,1MV1S@1224|Proteobacteria,2TS2D@28211|Alphaproteobacteria,2K0S2@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate	panC	-	6.3.2.1	ko:K01918	ko00410,ko00770,ko01100,ko01110,map00410,map00770,map01100,map01110	M00119	R02473	RC00096,RC00141	ko00000,ko00001,ko00002,ko01000	-	-	-	Pantoate_ligase
HKD2_k127_9151697_105	1123267.JONN01000001_gene2456	1.164e-38	146.0	COG0790@1|root,COG0790@2|Bacteria,1N8SR@1224|Proteobacteria,2UFFQ@28211|Alphaproteobacteria,2K5VX@204457|Sphingomonadales	204457|Sphingomonadales	S	FOG TPR repeat, SEL1 subfamily	-	-	-	ko:K07126	-	-	-	-	ko00000	-	-	-	Sel1
HKD2_k127_9151697_120	685778.AORL01000025_gene115	1.402e-18	91.0	COG2885@1|root,COG2885@2|Bacteria,1MZTV@1224|Proteobacteria,2U758@28211|Alphaproteobacteria,2K49Y@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the ompA family	pal	-	-	ko:K03640	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	OmpA
HKD2_k127_9151697_51	1550073.JROH01000001_gene571	1.245e-118	398.0	COG0823@1|root,COG0823@2|Bacteria,1MV09@1224|Proteobacteria,2TR03@28211|Alphaproteobacteria,2K1NT@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in the TonB-independent uptake of proteins	tolB	-	-	ko:K03641	-	-	-	-	ko00000,ko02000	2.C.1.2	-	-	PD40,TolB_N
HKD2_k127_9151697_96	1123267.JONN01000001_gene2450	9.215e-51	189.0	COG0824@1|root,COG0824@2|Bacteria,1MZH6@1224|Proteobacteria,2UBYM@28211|Alphaproteobacteria,2K4JS@204457|Sphingomonadales	204457|Sphingomonadales	S	thioesterase	-	-	-	ko:K07107	-	-	-	-	ko00000,ko01000	-	-	-	4HBT,4HBT_2
HKD2_k127_9151697_40	1123267.JONN01000001_gene2447	7.21e-143	466.0	COG2267@1|root,COG2267@2|Bacteria,1QDFI@1224|Proteobacteria,2U244@28211|Alphaproteobacteria,2K3CZ@204457|Sphingomonadales	204457|Sphingomonadales	I	Protein of unknown function (DUF3089)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3089
HKD2_k127_9151697_28	1123267.JONN01000001_gene2446	3.522e-189	596.0	COG2255@1|root,COG2255@2|Bacteria,1MU38@1224|Proteobacteria,2TQNG@28211|Alphaproteobacteria,2K0Y3@204457|Sphingomonadales	204457|Sphingomonadales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing	ruvB	-	3.6.4.12	ko:K03551	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvB_C,RuvB_N
HKD2_k127_9151697_53	745310.G432_11970	2.499e-114	380.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2K0GT@204457|Sphingomonadales	204457|Sphingomonadales	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_9151697_100	1123267.JONN01000001_gene2445	7.781e-48	175.0	COG3791@1|root,COG3791@2|Bacteria,1N023@1224|Proteobacteria,2UC7M@28211|Alphaproteobacteria,2K6R3@204457|Sphingomonadales	204457|Sphingomonadales	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_9151697_79	1545915.JROG01000004_gene2354	4.877e-76	261.0	COG1192@1|root,COG1192@2|Bacteria,1R62T@1224|Proteobacteria,2TUDH@28211|Alphaproteobacteria,2JZW4@204457|Sphingomonadales	204457|Sphingomonadales	D	Chromosome partitioning	-	-	-	-	-	-	-	-	-	-	-	-	AAA_31
HKD2_k127_9151697_82	392499.Swit_2140	3.377e-73	251.0	COG0632@1|root,COG0632@2|Bacteria,1MWJR@1224|Proteobacteria,2TSKM@28211|Alphaproteobacteria,2K2JA@204457|Sphingomonadales	204457|Sphingomonadales	L	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB	ruvA	-	3.6.4.12	ko:K03550	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	HHH_5,RuvA_C,RuvA_N
HKD2_k127_9151697_85	1449076.JOOE01000004_gene442	5.464e-70	241.0	COG0817@1|root,COG0817@2|Bacteria,1MUJI@1224|Proteobacteria,2U70Z@28211|Alphaproteobacteria,2K4Q1@204457|Sphingomonadales	204457|Sphingomonadales	L	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group	ruvC	-	3.1.22.4	ko:K01159	ko03440,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	RuvC
HKD2_k127_9151697_48	1550073.JROH01000026_gene970	1.45e-122	396.0	COG0217@1|root,COG0217@2|Bacteria,1MW3X@1224|Proteobacteria,2TRSK@28211|Alphaproteobacteria,2K0KW@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional regulatory protein	-	-	-	-	-	-	-	-	-	-	-	-	Transcrip_reg
HKD2_k127_9151697_109	1346791.M529_13315	1.695e-30	122.0	COG3750@1|root,COG3750@2|Bacteria,1N77J@1224|Proteobacteria,2UFX6@28211|Alphaproteobacteria,2K5Z1@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the UPF0335 family	-	-	-	-	-	-	-	-	-	-	-	-	DUF2312
HKD2_k127_9151697_25	1123267.JONN01000001_gene2437	2.246e-213	672.0	COG0469@1|root,COG0469@2|Bacteria,1MU21@1224|Proteobacteria,2TRFV@28211|Alphaproteobacteria,2K07D@204457|Sphingomonadales	204457|Sphingomonadales	G	Belongs to the pyruvate kinase family	pyk	-	2.7.1.40	ko:K00873	ko00010,ko00230,ko00620,ko01100,ko01110,ko01120,ko01130,ko01200,ko01230,ko04922,ko04930,ko05165,ko05203,ko05230,map00010,map00230,map00620,map01100,map01110,map01120,map01130,map01200,map01230,map04922,map04930,map05165,map05203,map05230	M00001,M00002,M00049,M00050	R00200,R00430,R01138,R01858,R02320	RC00002,RC00015	ko00000,ko00001,ko00002,ko01000,ko04131,ko04147	-	-	-	PK,PK_C
HKD2_k127_9151697_71	1123267.JONN01000001_gene2436	1.895e-85	291.0	COG0063@1|root,COG0063@2|Bacteria,1RDYQ@1224|Proteobacteria,2U7VX@28211|Alphaproteobacteria,2K40P@204457|Sphingomonadales	204457|Sphingomonadales	G	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration	nnrD	-	4.2.1.136	ko:K17758	-	-	-	-	ko00000,ko01000	-	-	-	Carb_kinase
HKD2_k127_9151697_57	1123267.JONN01000001_gene2435	1.02e-110	362.0	COG0406@1|root,COG0406@2|Bacteria,1RAPQ@1224|Proteobacteria,2U0U1@28211|Alphaproteobacteria,2K12D@204457|Sphingomonadales	204457|Sphingomonadales	G	Phosphoglycerate mutase family	-	-	-	-	-	-	-	-	-	-	-	-	His_Phos_1
HKD2_k127_9151697_29	1123267.JONN01000001_gene2433	2.036e-187	608.0	COG0438@1|root,COG0562@1|root,COG0438@2|Bacteria,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,2TTP4@28211|Alphaproteobacteria,2K2QF@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
HKD2_k127_9151697_38	1123267.JONN01000001_gene2433	1.389e-153	494.0	COG0438@1|root,COG0562@1|root,COG0438@2|Bacteria,COG0562@2|Bacteria,1MV4H@1224|Proteobacteria,2TTP4@28211|Alphaproteobacteria,2K2QF@204457|Sphingomonadales	204457|Sphingomonadales	M	UDP-galactopyranose mutase	-	-	5.4.99.9	ko:K01854	ko00052,ko00520,map00052,map00520	-	R00505,R09009	RC00317,RC02396	ko00000,ko00001,ko01000	-	-	-	GLF,Glyco_trans_1_4,NAD_binding_8
HKD2_k127_9151697_13	1449076.JOOE01000001_gene2272	2.023e-294	907.0	COG4799@1|root,COG4799@2|Bacteria,1MVAX@1224|Proteobacteria,2TRI1@28211|Alphaproteobacteria,2K0V7@204457|Sphingomonadales	204457|Sphingomonadales	I	acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)	pccB	-	2.1.3.15,6.4.1.3	ko:K01966	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_9151697_95	1117647.M5M_05120	1.909e-52	190.0	COG1764@1|root,COG1764@2|Bacteria,1RI5C@1224|Proteobacteria,1S4EM@1236|Gammaproteobacteria,1JAEX@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	O	Redox protein regulator of disulfide bond formation	-	-	-	-	-	-	-	-	-	-	-	-	OsmC
HKD2_k127_9151697_123	1174684.EBMC1_11390	1.282e-17	91.0	2BIRS@1|root,32CZA@2|Bacteria,1NENV@1224|Proteobacteria,2UHYW@28211|Alphaproteobacteria,2K7P3@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_87	1123267.JONN01000001_gene2431	4.302e-69	235.0	COG0346@1|root,COG0346@2|Bacteria,1RCYU@1224|Proteobacteria,2U728@28211|Alphaproteobacteria,2K46C@204457|Sphingomonadales	204457|Sphingomonadales	E	methylmalonyl-CoA epimerase	mce	-	5.1.99.1	ko:K05606	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00375,M00376,M00741	R02765,R09979	RC00780,RC02739	ko00000,ko00001,ko00002,ko01000	-	-	-	Glyoxalase_4
HKD2_k127_9151697_6	1123267.JONN01000001_gene2460	0.0	1176.0	COG1884@1|root,COG2185@1|root,COG1884@2|Bacteria,COG2185@2|Bacteria,1MUXX@1224|Proteobacteria,2TQYC@28211|Alphaproteobacteria,2K0E7@204457|Sphingomonadales	204457|Sphingomonadales	I	Methylmalonyl-CoA mutase	-	-	5.4.99.2	ko:K01847	ko00280,ko00630,ko00640,ko00720,ko01100,ko01120,ko01200,map00280,map00630,map00640,map00720,map01100,map01120,map01200	M00373,M00376,M00741	R00833	RC00395	ko00000,ko00001,ko00002,ko01000	-	-	-	B12-binding,MM_CoA_mutase
HKD2_k127_9151697_94	1121124.JNIX01000008_gene2447	1.213e-52	200.0	COG2819@1|root,COG2819@2|Bacteria,1R9SG@1224|Proteobacteria,2U7D0@28211|Alphaproteobacteria,2KGN8@204458|Caulobacterales	204458|Caulobacterales	S	Putative esterase	-	-	-	ko:K07017	-	-	-	-	ko00000	-	-	-	Esterase
HKD2_k127_9151697_10	1123267.JONN01000001_gene2461	2.452e-310	965.0	COG4770@1|root,COG4770@2|Bacteria,1P6RE@1224|Proteobacteria,2TRC2@28211|Alphaproteobacteria,2K050@204457|Sphingomonadales	204457|Sphingomonadales	I	acetyl propionyl-CoA carboxylase, alpha subunit	pccA	-	6.4.1.3	ko:K01965	ko00280,ko00630,ko00640,ko01100,ko01120,ko01130,ko01200,map00280,map00630,map00640,map01100,map01120,map01130,map01200	M00373,M00741	R01859	RC00097,RC00609	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,Biotin_lipoyl,CPSase_L_D2
HKD2_k127_9151697_54	1122137.AQXF01000004_gene1641	2.645e-113	373.0	COG1024@1|root,COG1024@2|Bacteria,1MXHV@1224|Proteobacteria,2TTEG@28211|Alphaproteobacteria	28211|Alphaproteobacteria	I	Belongs to the enoyl-CoA hydratase isomerase family	MA20_38145	-	-	-	-	-	-	-	-	-	-	-	ECH_1
HKD2_k127_9151697_84	1123267.JONN01000001_gene2462	8.758e-71	248.0	COG1028@1|root,COG1028@2|Bacteria,1MUS7@1224|Proteobacteria,2TTYG@28211|Alphaproteobacteria,2K4G4@204457|Sphingomonadales	204457|Sphingomonadales	IQ	KR domain	-	-	-	-	-	-	-	-	-	-	-	-	adh_short
HKD2_k127_9151697_78	509190.Cseg_0385	7.812e-79	270.0	COG0518@1|root,COG0518@2|Bacteria,1MV9U@1224|Proteobacteria,2TUIN@28211|Alphaproteobacteria,2KGIT@204458|Caulobacterales	204458|Caulobacterales	F	glutamine amidotransferase	-	-	-	-	-	-	-	-	-	-	-	-	GATase
HKD2_k127_9151697_23	1123267.JONN01000001_gene2463	2.746e-227	705.0	COG1062@1|root,COG1062@2|Bacteria,1MUK4@1224|Proteobacteria,2TT67@28211|Alphaproteobacteria,2K04T@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily	-	-	1.1.1.1,1.1.1.284	ko:K00121	ko00010,ko00071,ko00350,ko00625,ko00626,ko00680,ko00830,ko00980,ko00982,ko01100,ko01110,ko01120,ko01130,ko01200,ko01220,ko05204,map00010,map00071,map00350,map00625,map00626,map00680,map00830,map00980,map00982,map01100,map01110,map01120,map01130,map01200,map01220,map05204	-	R00623,R00754,R02124,R04880,R05233,R05234,R06917,R06927,R06983,R07105,R08281,R08306,R08310	RC00050,RC00087,RC00088,RC00099,RC00116,RC00649,RC01715,RC01734,RC02273	ko00000,ko00001,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_9151697_99	237727.NAP1_14988	1.013e-48	176.0	COG0662@1|root,COG0662@2|Bacteria,1RHWU@1224|Proteobacteria,2UA4V@28211|Alphaproteobacteria,2K5VQ@204457|Sphingomonadales	204457|Sphingomonadales	G	Mannose-6-phosphate isomerase	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_9151697_92	1207055.C100_10825	4.567e-54	192.0	COG0346@1|root,COG0346@2|Bacteria,1RH8G@1224|Proteobacteria,2U9BR@28211|Alphaproteobacteria,2KA2N@204457|Sphingomonadales	204457|Sphingomonadales	E	COG0346 Lactoylglutathione lyase and related lyases	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_41	1245469.S58_22470	2.337e-138	447.0	COG0627@1|root,COG0627@2|Bacteria,1MUID@1224|Proteobacteria,2TQSM@28211|Alphaproteobacteria,3JUQA@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Serine hydrolase involved in the detoxification of formaldehyde	fghA	-	3.1.2.12	ko:K01070	ko00680,ko01120,ko01200,map00680,map01120,map01200	-	R00527	RC00167,RC00320	ko00000,ko00001,ko01000	-	CE1	-	Esterase
HKD2_k127_9151697_15	204669.Acid345_3950	8.991e-277	866.0	COG3540@1|root,COG3540@2|Bacteria,3Y3WC@57723|Acidobacteria,2JKM8@204432|Acidobacteriia	204432|Acidobacteriia	P	PhoD-like phosphatase, N-terminal domain	-	-	3.1.3.1	ko:K01113	ko00790,ko01100,ko02020,map00790,map01100,map02020	M00126	R04620	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	PhoD,PhoD_N
HKD2_k127_9151697_74	1088721.NSU_4744	4.543e-83	291.0	COG3174@1|root,COG3174@2|Bacteria,1NDBI@1224|Proteobacteria,2U0C9@28211|Alphaproteobacteria,2K374@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4010)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4010,MgtC
HKD2_k127_9151697_124	391626.OAN307_c18840	2.406e-14	76.0	COG2826@1|root,COG2826@2|Bacteria,1PP49@1224|Proteobacteria,2TRVA@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	COG2826 Transposase and inactivated derivatives, IS30 family	-	-	-	-	-	-	-	-	-	-	-	-	HTH_38,rve
HKD2_k127_9151697_62	1288298.rosmuc_03900	6.221e-97	325.0	COG5340@1|root,COG5340@2|Bacteria,1RD3T@1224|Proteobacteria,2U83V@28211|Alphaproteobacteria	28211|Alphaproteobacteria	K	Psort location Cytoplasmic, score	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_122	1207063.P24_14529	3.317e-18	86.0	28IJ7@1|root,2Z8K5@2|Bacteria,1R5WT@1224|Proteobacteria,2U2ST@28211|Alphaproteobacteria,2JV1H@204441|Rhodospirillales	204441|Rhodospirillales	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD2_k127_9151697_72	412597.AEPN01000052_gene3746	1.436e-84	286.0	28IJ7@1|root,2Z8K5@2|Bacteria,1R5WT@1224|Proteobacteria,2U2ST@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Nucleotidyl transferase AbiEii toxin, Type IV TA system	-	-	-	-	-	-	-	-	-	-	-	-	AbiEii
HKD2_k127_9151697_19	1030157.AFMP01000016_gene2436	1.072e-245	771.0	COG0608@1|root,COG0608@2|Bacteria,1MU1M@1224|Proteobacteria,2TRZQ@28211|Alphaproteobacteria,2K0VW@204457|Sphingomonadales	204457|Sphingomonadales	L	single-stranded-DNA-specific exonuclease RecJ	recJ	-	-	ko:K07462	ko03410,ko03430,ko03440,map03410,map03430,map03440	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	DHH,DHHA1
HKD2_k127_9151697_34	1123267.JONN01000001_gene2471	5.219e-162	515.0	COG1494@1|root,COG1494@2|Bacteria,1MUB1@1224|Proteobacteria,2TSPE@28211|Alphaproteobacteria,2JZUH@204457|Sphingomonadales	204457|Sphingomonadales	G	in Escherichia coli this protein forms a dimer and binds manganese	glpX	-	3.1.3.11,3.1.3.37	ko:K11532	ko00010,ko00030,ko00051,ko00680,ko00710,ko01100,ko01110,ko01120,ko01130,ko01200,map00010,map00030,map00051,map00680,map00710,map01100,map01110,map01120,map01130,map01200	M00003,M00165,M00167	R00762,R01845,R04780	RC00017	ko00000,ko00001,ko00002,ko01000	-	-	-	FBPase_glpX
HKD2_k127_9151697_104	1123267.JONN01000001_gene2473	2.095e-40	159.0	2E3B5@1|root,32YAP@2|Bacteria,1N7KQ@1224|Proteobacteria,2UHG1@28211|Alphaproteobacteria,2K43M@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD2_k127_9151697_113	1123267.JONN01000001_gene482	2.603e-27	118.0	2BSC6@1|root,32ME1@2|Bacteria,1PPBT@1224|Proteobacteria,2V1U9@28211|Alphaproteobacteria,2KC1J@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9151697_108	29581.BW37_05125	1.651e-32	132.0	COG1597@1|root,COG1597@2|Bacteria,1MY37@1224|Proteobacteria,2VZ36@28216|Betaproteobacteria,472UX@75682|Oxalobacteraceae	28216|Betaproteobacteria	G	Diacylglycerol kinase	-	-	-	-	-	-	-	-	-	-	-	-	DAGK_cat
HKD2_k127_9172197_3	1057002.KB905370_gene2611	6.945e-112	382.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
HKD2_k127_9172197_6	1096930.L284_12630	4.87e-45	173.0	COG0664@1|root,COG0664@2|Bacteria,1PIN3@1224|Proteobacteria,2TSA8@28211|Alphaproteobacteria,2K3KX@204457|Sphingomonadales	204457|Sphingomonadales	K	Crp-like helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_9172197_0	1123267.JONN01000001_gene1177	1.414e-201	640.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQPG@28211|Alphaproteobacteria,2K0T8@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	-	-	-	-	-	-	-	-	-	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9172197_1	1030157.AFMP01000036_gene2681	2.096e-166	534.0	COG3288@1|root,COG3288@2|Bacteria,1MVXU@1224|Proteobacteria,2TSZN@28211|Alphaproteobacteria,2K062@204457|Sphingomonadales	204457|Sphingomonadales	C	NAD(P) transhydrogenase subunit alpha	pntAA	-	1.6.1.2	ko:K00324	ko00760,ko01100,map00760,map01100	-	R00112	RC00001	ko00000,ko00001,ko01000	-	-	-	AlaDh_PNT_C,AlaDh_PNT_N
HKD2_k127_9172197_4	237727.NAP1_04025	2.869e-93	319.0	COG0665@1|root,COG0665@2|Bacteria,1MY0G@1224|Proteobacteria,2TRM2@28211|Alphaproteobacteria,2K9SG@204457|Sphingomonadales	204457|Sphingomonadales	E	FAD dependent oxidoreductase	-	-	-	-	-	-	-	-	-	-	-	-	DAO
HKD2_k127_9172197_5	1437882.AZRU01000040_gene4689	4.513e-51	186.0	COG2606@1|root,COG2606@2|Bacteria,1RD82@1224|Proteobacteria,1S235@1236|Gammaproteobacteria,1YFX8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Aminoacyl-tRNA editing domain	-	-	-	-	-	-	-	-	-	-	-	-	tRNA_edit
HKD2_k127_9172197_2	1123267.JONN01000002_gene325	9.654e-156	506.0	COG2200@1|root,COG4252@1|root,COG2200@2|Bacteria,COG4252@2|Bacteria,1N299@1224|Proteobacteria,2U5C8@28211|Alphaproteobacteria,2K2WP@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	CHASE2,EAL
HKD2_k127_9270401_46	1123267.JONN01000001_gene1999	4.72e-50	180.0	COG0596@1|root,COG0596@2|Bacteria,1N5ZI@1224|Proteobacteria,2TS7X@28211|Alphaproteobacteria,2KEG6@204457|Sphingomonadales	204457|Sphingomonadales	S	hydrolases or acyltransferases (alpha beta hydrolase superfamily)	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1
HKD2_k127_9270401_41	627192.SLG_35190	7.781e-69	238.0	COG0781@1|root,COG0781@2|Bacteria,1RHFZ@1224|Proteobacteria,2UBQA@28211|Alphaproteobacteria,2K4I2@204457|Sphingomonadales	204457|Sphingomonadales	K	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons	nusB	-	-	ko:K03625	-	-	-	-	ko00000,ko03009,ko03021	-	-	-	NusB
HKD2_k127_9270401_31	745310.G432_05730	7.311e-94	319.0	COG0611@1|root,COG0611@2|Bacteria,1MU9X@1224|Proteobacteria,2TTI6@28211|Alphaproteobacteria,2K0EU@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1	thiL	-	2.7.4.16	ko:K00946	ko00730,ko01100,map00730,map01100	M00127	R00617	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	AIRS,AIRS_C
HKD2_k127_9270401_3	1219045.BV98_000890	0.0	1035.0	COG3808@1|root,COG3808@2|Bacteria,1MUQ3@1224|Proteobacteria,2TR9G@28211|Alphaproteobacteria,2K0XA@204457|Sphingomonadales	204457|Sphingomonadales	C	Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force	hppA	-	3.6.1.1	ko:K15987	ko00190,map00190	-	-	-	ko00000,ko00001,ko01000	3.A.10.1	-	-	H_PPase
HKD2_k127_9270401_21	583345.Mmol_0121	1.28e-138	448.0	COG0604@1|root,COG0604@2|Bacteria,1MWBD@1224|Proteobacteria,2VH3Z@28216|Betaproteobacteria	28216|Betaproteobacteria	C	PFAM Alcohol dehydrogenase zinc-binding domain protein	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_9270401_51	1123267.JONN01000001_gene2022	2.164e-45	164.0	COG0361@1|root,COG0361@2|Bacteria,1MZFU@1224|Proteobacteria,2UBRU@28211|Alphaproteobacteria,2K5VJ@204457|Sphingomonadales	204457|Sphingomonadales	J	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex	infA	-	-	ko:K02518	-	-	-	-	ko00000,ko03012	-	-	-	eIF-1a
HKD2_k127_9270401_34	1123267.JONN01000001_gene2023	9.2e-90	299.0	COG0424@1|root,COG0424@2|Bacteria,1RH6H@1224|Proteobacteria,2TSS5@28211|Alphaproteobacteria,2K3WJ@204457|Sphingomonadales	204457|Sphingomonadales	D	Maf-like protein	maf	-	-	ko:K06287	-	-	-	-	ko00000	-	-	-	Maf
HKD2_k127_9270401_42	392499.Swit_4112	1.878e-62	226.0	COG1530@1|root,COG1530@2|Bacteria,1RC15@1224|Proteobacteria,2U5PB@28211|Alphaproteobacteria,2K2AZ@204457|Sphingomonadales	204457|Sphingomonadales	J	ribonuclease E activity	-	-	-	-	-	-	-	-	-	-	-	-	RNase_E_G
HKD2_k127_9270401_71	629773.AORY01000004_gene5	1.139e-17	85.0	COG3024@1|root,COG3024@2|Bacteria,1NGJ8@1224|Proteobacteria,2VEGK@28211|Alphaproteobacteria,2K7UE@204457|Sphingomonadales	204457|Sphingomonadales	S	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase	yacG	-	-	ko:K09862	-	-	-	-	ko00000	-	-	-	YacG
HKD2_k127_9270401_74	1197906.CAJQ02000003_gene3219	1.587e-07	55.0	COG1961@1|root,COG1961@2|Bacteria,1MWCZ@1224|Proteobacteria,2TRIY@28211|Alphaproteobacteria,3JUGV@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Resolvase	-	-	-	-	-	-	-	-	-	-	-	-	Recombinase,Resolvase,Zn_ribbon_recom
HKD2_k127_9270401_11	504728.K649_11955	9.423e-178	571.0	COG0365@1|root,COG0365@2|Bacteria,1WNGH@1297|Deinococcus-Thermus	1297|Deinococcus-Thermus	I	AMP-binding enzyme C-terminal domain	-	-	6.2.1.32	ko:K08295	ko00627,ko01120,map00627,map01120	-	R00982	RC00004,RC00174	ko00000,ko00001,ko01000	-	-	-	AMP-binding,AMP-binding_C
HKD2_k127_9270401_48	394221.Mmar10_2689	2.498e-47	174.0	COG0251@1|root,COG0251@2|Bacteria,1RHSP@1224|Proteobacteria,2U9A9@28211|Alphaproteobacteria	28211|Alphaproteobacteria	J	endoribonuclease L-PSP	-	-	3.5.99.10	ko:K09022	-	-	R11098,R11099	RC03275,RC03354	ko00000,ko01000	-	-	-	Ribonuc_L-PSP
HKD2_k127_9270401_25	412597.AEPN01000021_gene884	2.747e-133	436.0	COG1960@1|root,COG1960@2|Bacteria,1MVQH@1224|Proteobacteria,2TTX8@28211|Alphaproteobacteria,2PWA2@265|Paracoccus	28211|Alphaproteobacteria	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	1.3.8.7	ko:K00249	ko00071,ko00280,ko00410,ko00640,ko01100,ko01110,ko01130,ko01200,ko01212,ko03320,map00071,map00280,map00410,map00640,map01100,map01110,map01130,map01200,map01212,map03320	M00013,M00036,M00087	R00924,R01175,R01279,R02661,R03172,R03777,R03857,R03990,R04095,R04432,R04751,R04754	RC00052,RC00068,RC00076,RC00095,RC00148,RC00246	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9270401_2	1537715.JQFJ01000002_gene1042	0.0	1245.0	COG0654@1|root,COG1902@1|root,COG0654@2|Bacteria,COG1902@2|Bacteria,1MVE0@1224|Proteobacteria,2TQPY@28211|Alphaproteobacteria,2K127@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH flavin oxidoreductase NADH oxidase	-	-	1.14.13.40	ko:K09461	ko00627,ko01120,map00627,map01120	-	R03998,R03999	RC00244	ko00000,ko00001,ko01000	-	-	-	FAD_binding_3,Oxidored_FMN
HKD2_k127_9270401_13	1123267.JONN01000001_gene2029	2.065e-164	527.0	COG4805@1|root,COG4805@2|Bacteria,1MZDR@1224|Proteobacteria,2TTBI@28211|Alphaproteobacteria,2K1T6@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9270401_22	1545915.JROG01000003_gene1682	3.373e-138	450.0	COG0123@1|root,COG0123@2|Bacteria,1MU7P@1224|Proteobacteria,2TRRH@28211|Alphaproteobacteria,2K0SH@204457|Sphingomonadales	204457|Sphingomonadales	BQ	Histone deacetylase domain	-	-	-	-	-	-	-	-	-	-	-	-	Hist_deacetyl
HKD2_k127_9270401_20	1379701.JPJC01000128_gene2580	1.229e-140	452.0	COG2025@1|root,COG2025@2|Bacteria,1MUFI@1224|Proteobacteria,2TR10@28211|Alphaproteobacteria,2K1AU@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein	etfA	-	-	ko:K03522	-	-	-	-	ko00000,ko04147	-	-	-	ETF,ETF_alpha
HKD2_k127_9270401_27	1331060.RLDS_25385	7.832e-124	402.0	COG2086@1|root,COG2086@2|Bacteria,1MVH6@1224|Proteobacteria,2TR4J@28211|Alphaproteobacteria,2K0GH@204457|Sphingomonadales	204457|Sphingomonadales	C	Electron transfer flavoprotein	-	-	-	ko:K03521	-	-	-	-	ko00000	-	-	-	ETF
HKD2_k127_9270401_73	1223410.KN050846_gene2564	4.213e-09	67.0	COG4319@1|root,COG4319@2|Bacteria,4PAB3@976|Bacteroidetes,1I6M9@117743|Flavobacteriia	976|Bacteroidetes	S	ketosteroid isomerase	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440
HKD2_k127_9270401_8	1123267.JONN01000001_gene2034	2.118e-217	680.0	COG0045@1|root,COG0045@2|Bacteria,1MVCE@1224|Proteobacteria,2TRXK@28211|Alphaproteobacteria,2K12N@204457|Sphingomonadales	204457|Sphingomonadales	C	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit	sucC	-	6.2.1.5	ko:K01903	ko00020,ko00640,ko00660,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,map00020,map00640,map00660,map00720,map01100,map01110,map01120,map01130,map01200	M00009,M00011,M00173,M00374,M00620	R00405,R02404	RC00004,RC00014	ko00000,ko00001,ko00002,ko01000	-	-	-	ATP-grasp_2,Ligase_CoA
HKD2_k127_9270401_15	1123267.JONN01000001_gene2035	5.78e-159	507.0	COG0389@1|root,COG0389@2|Bacteria,1MUUH@1224|Proteobacteria,2TSJN@28211|Alphaproteobacteria,2K1Q4@204457|Sphingomonadales	204457|Sphingomonadales	L	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII	dinB	-	2.7.7.7	ko:K02346	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	IMS,IMS_C,IMS_HHH
HKD2_k127_9270401_32	1123267.JONN01000001_gene2036	2.438e-93	310.0	COG1329@1|root,COG1329@2|Bacteria,1MWI2@1224|Proteobacteria,2TTVP@28211|Alphaproteobacteria,2K0TA@204457|Sphingomonadales	204457|Sphingomonadales	K	CarD family transcriptional regulator	-	-	-	ko:K07736	-	-	-	-	ko00000,ko03000	-	-	-	CarD_CdnL_TRCF
HKD2_k127_9270401_55	1112212.JH584235_gene2173	3.562e-42	164.0	COG3595@1|root,COG3595@2|Bacteria,1N374@1224|Proteobacteria,2UDAB@28211|Alphaproteobacteria,2K1A2@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HKD2_k127_9270401_58	1123267.JONN01000001_gene2038	7.388e-34	139.0	2DR57@1|root,33A7H@2|Bacteria,1Q5GH@1224|Proteobacteria,2UQ0P@28211|Alphaproteobacteria,2KCHF@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative auto-transporter adhesin, head GIN domain	-	-	-	-	-	-	-	-	-	-	-	-	DUF2807
HKD2_k127_9270401_43	59196.RICGR_0029	3.956e-60	214.0	COG5424@1|root,COG5424@2|Bacteria	2|Bacteria	H	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ	CP_1111	GO:0005575,GO:0005576	1.3.3.11	ko:K06137	-	-	-	-	ko00000,ko01000	-	-	-	Haem_oxygenas_2,TENA_THI-4
HKD2_k127_9270401_52	1123267.JONN01000001_gene2039	8.081e-44	163.0	COG5458@1|root,COG5458@2|Bacteria,1N054@1224|Proteobacteria,2UBY1@28211|Alphaproteobacteria,2K5VN@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF1489)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1489
HKD2_k127_9270401_9	1123267.JONN01000001_gene2040	1.512e-211	667.0	COG2239@1|root,COG2239@2|Bacteria,1MW24@1224|Proteobacteria,2TRWK@28211|Alphaproteobacteria,2K0AK@204457|Sphingomonadales	204457|Sphingomonadales	P	Acts as a magnesium transporter	mgtE	-	-	ko:K06213	-	-	-	-	ko00000,ko02000	1.A.26.1	-	-	CBS,MgtE,MgtE_N
HKD2_k127_9270401_37	13689.BV96_00461	2.219e-76	267.0	COG0652@1|root,COG0652@2|Bacteria,1R9ZQ@1224|Proteobacteria,2U591@28211|Alphaproteobacteria,2K3YQ@204457|Sphingomonadales	204457|Sphingomonadales	O	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides	-	-	5.2.1.8	ko:K01802	-	-	-	-	ko00000,ko01000	-	-	-	Pro_isomerase
HKD2_k127_9270401_36	1123267.JONN01000001_gene2042	6.66e-85	288.0	COG0300@1|root,COG0300@2|Bacteria,1RG9T@1224|Proteobacteria,2TW0V@28211|Alphaproteobacteria,2KCP4@204457|Sphingomonadales	204457|Sphingomonadales	S	KR domain	-	-	-	ko:K07124	-	-	-	-	ko00000	-	-	-	adh_short
HKD2_k127_9270401_1	1123267.JONN01000001_gene2043	0.0	1280.0	COG1222@1|root,COG1222@2|Bacteria,1QTV4@1224|Proteobacteria,2U0Q7@28211|Alphaproteobacteria,2K0N9@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the AAA ATPase family	-	-	-	ko:K13525	ko04141,ko05134,map04141,map05134	M00400,M00403	-	-	ko00000,ko00001,ko00002,ko03019,ko04131,ko04147	3.A.16.1	-	-	AAA,CDC48_2,CDC48_N
HKD2_k127_9270401_33	1123267.JONN01000001_gene2045	2.488e-91	306.0	COG3963@1|root,COG3963@2|Bacteria,1R81B@1224|Proteobacteria,2U46R@28211|Alphaproteobacteria,2K2HK@204457|Sphingomonadales	204457|Sphingomonadales	I	Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_25
HKD2_k127_9270401_23	1123267.JONN01000001_gene2046	1.946e-137	452.0	COG1502@1|root,COG1502@2|Bacteria,1MWUW@1224|Proteobacteria,2U2TG@28211|Alphaproteobacteria,2K02V@204457|Sphingomonadales	204457|Sphingomonadales	I	COG1502 Phosphatidylserine phosphatidylglycerophosphate cardiolipi n synthases and related enzymes	-	-	-	ko:K06131	ko00564,ko01100,map00564,map01100	-	R07390	RC00017	ko00000,ko00001,ko01000	-	-	-	PLDc_2
HKD2_k127_9270401_45	1123267.JONN01000001_gene2047	3.873e-54	193.0	COG1758@1|root,COG1758@2|Bacteria,1N6TX@1224|Proteobacteria,2U9BQ@28211|Alphaproteobacteria,2K5I6@204457|Sphingomonadales	204457|Sphingomonadales	K	Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits	rpoZ	-	2.7.7.6	ko:K03060	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb6
HKD2_k127_9270401_30	1123267.JONN01000001_gene2424	6.049e-101	332.0	COG1407@1|root,COG1407@2|Bacteria,1RC5G@1224|Proteobacteria,2TU2T@28211|Alphaproteobacteria,2K25E@204457|Sphingomonadales	204457|Sphingomonadales	S	ICC-like phosphoesterases	-	-	-	ko:K06953	-	-	-	-	ko00000	-	-	-	Metallophos
HKD2_k127_9270401_68	1123267.JONN01000001_gene2423	2.328e-22	98.0	COG0115@1|root,COG0147@1|root,COG0115@2|Bacteria,COG0147@2|Bacteria,1MVBJ@1224|Proteobacteria,2TUBY@28211|Alphaproteobacteria,2K1FB@204457|Sphingomonadales	204457|Sphingomonadales	EH	component I	pabB	-	2.6.1.85,4.1.3.38	ko:K01665,ko:K03342	ko00790,map00790	-	R01716,R05553	RC00010,RC01418,RC01843,RC02148	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_4,Anth_synt_I_N,Chorismate_bind
HKD2_k127_9270401_12	1123267.JONN01000001_gene2422	2.332e-169	541.0	COG2355@1|root,COG2355@2|Bacteria,1MWEW@1224|Proteobacteria,2TR5C@28211|Alphaproteobacteria,2K0GT@204457|Sphingomonadales	204457|Sphingomonadales	E	Zn-dependent dipeptidase, microsomal dipeptidase	-	-	3.4.13.19	ko:K01273	-	-	-	-	ko00000,ko00537,ko01000,ko01002,ko04147	-	-	-	Peptidase_M19
HKD2_k127_9270401_29	745310.G432_11885	1.762e-107	354.0	COG0491@1|root,COG0491@2|Bacteria,1MUDN@1224|Proteobacteria,2TQJ9@28211|Alphaproteobacteria,2K19S@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_9270401_61	1123267.JONN01000001_gene2419	1.221e-32	126.0	COG0333@1|root,COG0333@2|Bacteria,1PU3Y@1224|Proteobacteria,2UF54@28211|Alphaproteobacteria,2K6RY@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the bacterial ribosomal protein bL32 family	rpmF	-	-	ko:K02911	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011,ko03029	-	-	-	Ribosomal_L32p
HKD2_k127_9270401_16	1123267.JONN01000001_gene2418	2.97e-151	485.0	COG0416@1|root,COG0416@2|Bacteria,1MVM3@1224|Proteobacteria,2TR53@28211|Alphaproteobacteria,2K0QU@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA	plsX	-	2.3.1.15	ko:K03621	ko00561,ko00564,ko01100,ko01110,map00561,map00564,map01100,map01110	M00089	R00851,R09380	RC00004,RC00039,RC00041	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FA_synthesis
HKD2_k127_9270401_14	1030157.AFMP01000043_gene1696	2.751e-161	514.0	COG0332@1|root,COG0332@2|Bacteria,1MU9N@1224|Proteobacteria,2TR60@28211|Alphaproteobacteria,2K1XQ@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids	fabH	-	2.3.1.180	ko:K00648	ko00061,ko01100,ko01212,map00061,map01100,map01212	M00082,M00083	R10707	RC00004,RC02729,RC02888	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	ACP_syn_III,ACP_syn_III_C
HKD2_k127_9270401_49	1123267.JONN01000001_gene2416	2.882e-46	170.0	COG0776@1|root,COG0776@2|Bacteria,1RH5Z@1224|Proteobacteria,2UCDG@28211|Alphaproteobacteria,2K62D@204457|Sphingomonadales	204457|Sphingomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	himA	-	-	ko:K04764	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_9270401_57	13689.BV96_00963	7.235e-34	134.0	COG0789@1|root,COG0789@2|Bacteria,1RGYB@1224|Proteobacteria,2U9A5@28211|Alphaproteobacteria,2K5Y3@204457|Sphingomonadales	204457|Sphingomonadales	K	transcriptional	-	-	-	-	-	-	-	-	-	-	-	-	MerR_1
HKD2_k127_9270401_50	1346791.M529_07960	1.161e-45	171.0	COG2062@1|root,COG2062@2|Bacteria,1N0FX@1224|Proteobacteria,2UBYD@28211|Alphaproteobacteria,2K4JB@204457|Sphingomonadales	204457|Sphingomonadales	T	phosphohistidine phosphatase	sixA	-	-	ko:K08296	-	-	-	-	ko00000,ko01000	-	-	-	His_Phos_1
HKD2_k127_9270401_0	1123267.JONN01000001_gene2414	0.0	1297.0	COG1199@1|root,COG1199@2|Bacteria,1MVCU@1224|Proteobacteria,2TUKS@28211|Alphaproteobacteria,2K15X@204457|Sphingomonadales	204457|Sphingomonadales	KL	Helicase	dinG	-	3.6.4.12	ko:K03722	-	-	-	-	ko00000,ko01000,ko03400	-	-	-	Helicase_C_2
HKD2_k127_9270401_56	94624.Bpet2959	8.373e-37	142.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,2VSQ1@28216|Betaproteobacteria,3T4VH@506|Alcaligenaceae	28216|Betaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_9270401_6	1248760.ANFZ01000021_gene391	1.32e-246	771.0	COG1384@1|root,COG1384@2|Bacteria,1MV32@1224|Proteobacteria,2TQYH@28211|Alphaproteobacteria,2K1S0@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the class-I aminoacyl-tRNA synthetase family	lysS	-	6.1.1.6	ko:K04566	ko00970,map00970	M00360	R03658	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	tRNA-synt_1f
HKD2_k127_9270401_17	1123267.JONN01000001_gene2410	1.321e-150	486.0	COG0793@1|root,COG0793@2|Bacteria,1RGID@1224|Proteobacteria,2U9TM@28211|Alphaproteobacteria,2KD0M@204457|Sphingomonadales	204457|Sphingomonadales	M	tail specific protease	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_S41,Peptidase_S41_N
HKD2_k127_9270401_47	1123267.JONN01000001_gene2409	3.091e-49	181.0	COG1522@1|root,COG1522@2|Bacteria,1NESY@1224|Proteobacteria,2UGP7@28211|Alphaproteobacteria,2K76T@204457|Sphingomonadales	204457|Sphingomonadales	K	AsnC-type helix-turn-helix domain	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_AsnC-type
HKD2_k127_9270401_10	1123269.NX02_04845	4.651e-190	598.0	COG2267@1|root,COG2267@2|Bacteria,1PB1R@1224|Proteobacteria,2TVHB@28211|Alphaproteobacteria,2K25C@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	-	-	-	-	-	-	-	-	-	-	Abhydrolase_1,Hydrolase_4
HKD2_k127_9270401_4	1123267.JONN01000001_gene2406	8.284e-270	844.0	COG4805@1|root,COG4805@2|Bacteria,1MUBX@1224|Proteobacteria,2TSUQ@28211|Alphaproteobacteria,2K0GU@204457|Sphingomonadales	204457|Sphingomonadales	O	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	DUF885
HKD2_k127_9270401_64	1123267.JONN01000001_gene2405	8.05e-29	129.0	COG5455@1|root,COG5455@2|Bacteria,1RJVB@1224|Proteobacteria,2U9H6@28211|Alphaproteobacteria,2K5B9@204457|Sphingomonadales	204457|Sphingomonadales	S	Nickel/cobalt transporter regulator	-	-	-	-	-	-	-	-	-	-	-	-	RcnB
HKD2_k127_9270401_44	745310.G432_08690	3.413e-56	199.0	COG2080@1|root,COG2080@2|Bacteria,1RD8C@1224|Proteobacteria,2U6Z6@28211|Alphaproteobacteria,2KCVI@204457|Sphingomonadales	204457|Sphingomonadales	C	[2Fe-2S] binding domain	-	-	1.3.99.16	ko:K07302	-	-	-	-	ko00000,ko01000	-	-	-	Fer2,Fer2_2
HKD2_k127_9270401_38	1123267.JONN01000001_gene2403	4.054e-75	262.0	COG2267@1|root,COG2267@2|Bacteria,1P7JV@1224|Proteobacteria,2TUWY@28211|Alphaproteobacteria,2K70A@204457|Sphingomonadales	204457|Sphingomonadales	I	Serine aminopeptidase, S33	-	-	3.1.1.24	ko:K01055	ko00362,ko01100,ko01120,ko01220,map00362,map01100,map01120,map01220	M00568	R02991	RC00825	ko00000,ko00001,ko00002,ko01000	-	-	-	Abhydrolase_1
HKD2_k127_9270401_62	1114964.L485_09185	1.841e-30	129.0	COG1226@1|root,32YV7@2|Bacteria,1N7MV@1224|Proteobacteria,2UMMN@28211|Alphaproteobacteria,2KDAI@204457|Sphingomonadales	204457|Sphingomonadales	P	Ion channel	-	-	-	-	-	-	-	-	-	-	-	-	Ion_trans_2
HKD2_k127_9270401_70	13690.CP98_00125	2.627e-18	92.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD2_k127_9270401_67	13690.CP98_00125	3.402e-23	106.0	2C852@1|root,32YB2@2|Bacteria,1RH28@1224|Proteobacteria,2UG74@28211|Alphaproteobacteria,2K7DU@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4136)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4136
HKD2_k127_9270401_54	1144305.PMI02_00732	2.804e-42	164.0	28PW7@1|root,2ZCGM@2|Bacteria,1R7U8@1224|Proteobacteria,2TSV3@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
HKD2_k127_9270401_66	398525.KB900701_gene5678	1.01e-23	108.0	2E06S@1|root,32VUR@2|Bacteria,1N3ZV@1224|Proteobacteria,2UEPV@28211|Alphaproteobacteria,3JZKC@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9270401_53	237609.PSAKL28_25300	1.65e-43	164.0	2E3B5@1|root,32YAP@2|Bacteria,1N7KQ@1224|Proteobacteria,1SF5B@1236|Gammaproteobacteria	1236|Gammaproteobacteria	S	Protein of unknown function (DUF2721)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2721
HKD2_k127_9270401_39	1408418.JNJH01000010_gene3490	8.129e-75	258.0	2DM5C@1|root,31SFK@2|Bacteria,1RHYU@1224|Proteobacteria,2UIDQ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9270401_28	1123267.JONN01000001_gene519	1.816e-118	387.0	COG2017@1|root,COG2017@2|Bacteria,1RGXX@1224|Proteobacteria,2U93Z@28211|Alphaproteobacteria,2K56V@204457|Sphingomonadales	204457|Sphingomonadales	G	Aldose 1-epimerase	-	-	5.1.3.3	ko:K01785	ko00010,ko00052,ko01100,ko01110,ko01120,ko01130,map00010,map00052,map01100,map01110,map01120,map01130	M00632	R01602,R10619	RC00563	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldose_epim
HKD2_k127_9270401_35	1545915.JROG01000008_gene3482	3.489e-85	289.0	COG1482@1|root,COG1482@2|Bacteria,1P6JR@1224|Proteobacteria,2U30V@28211|Alphaproteobacteria,2K0Y1@204457|Sphingomonadales	204457|Sphingomonadales	G	isomerase	-	-	5.3.1.8	ko:K01809	ko00051,ko00520,ko01100,ko01110,ko01130,map00051,map00520,map01100,map01110,map01130	M00114	R01819	RC00376	ko00000,ko00001,ko00002,ko01000	-	-	-	-
HKD2_k127_9270401_69	316057.RPD_2515	9.503e-22	104.0	COG0664@1|root,COG0664@2|Bacteria,1Q70G@1224|Proteobacteria,2UC77@28211|Alphaproteobacteria,3K4MK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Cyclic nucleotide-monophosphate binding domain	-	-	-	ko:K10914	ko02020,ko02024,ko02025,ko02026,ko05111,map02020,map02024,map02025,map02026,map05111	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_Crp_2,cNMP_binding
HKD2_k127_9270401_18	1205680.CAKO01000042_gene5366	7.186e-148	475.0	COG1262@1|root,COG1262@2|Bacteria,1MZ25@1224|Proteobacteria,2TRJH@28211|Alphaproteobacteria,2JZAC@204441|Rhodospirillales	204441|Rhodospirillales	S	Sulfatase-modifying factor enzyme 1	-	-	-	ko:K20333	ko02024,map02024	-	-	-	ko00000,ko00001	-	-	-	FGE-sulfatase
HKD2_k127_9270401_7	1336243.JAEA01000001_gene1975	1.423e-245	768.0	COG3119@1|root,COG3119@2|Bacteria,1MUJH@1224|Proteobacteria,2TSB8@28211|Alphaproteobacteria,1JWUA@119045|Methylobacteriaceae	28211|Alphaproteobacteria	P	PFAM sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	DUF4994,Sulfatase,Sulfatase_C
HKD2_k127_9270401_5	264198.Reut_B4712	5.971e-262	816.0	COG3119@1|root,COG3119@2|Bacteria,1MV0B@1224|Proteobacteria,2VNB8@28216|Betaproteobacteria,1KGH9@119060|Burkholderiaceae	28216|Betaproteobacteria	P	Sulfatase	-	-	3.1.6.1	ko:K01130	ko00140,ko00600,map00140,map00600	-	R03980,R04856	RC00128,RC00231	ko00000,ko00001,ko01000	-	-	-	Sulfatase
HKD2_k127_9270401_63	1144305.PMI02_04502	4.357e-29	121.0	COG4828@1|root,COG4828@2|Bacteria,1N79M@1224|Proteobacteria,2UT86@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Protein of unknown function (DUF1622)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1622
HKD2_k127_9270401_59	1144305.PMI02_00731	5.583e-33	141.0	COG0385@1|root,COG0385@2|Bacteria,1N9IH@1224|Proteobacteria	1224|Proteobacteria	S	Bile acid	-	-	-	ko:K03453	-	-	-	-	ko00000	2.A.28	-	-	SBF
HKD2_k127_9270401_60	745310.G432_12915	9.924e-33	133.0	COG2149@1|root,COG2149@2|Bacteria,1RKB3@1224|Proteobacteria,2UEIP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Domain of unknown function (DUF202)	-	-	-	ko:K00389	-	-	-	-	ko00000	-	-	-	DUF202
HKD2_k127_9270401_19	1144305.PMI02_04518	1.007e-145	481.0	COG3515@1|root,COG3515@2|Bacteria,1NRMK@1224|Proteobacteria	1224|Proteobacteria	S	Protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9270401_24	1305737.JAFX01000001_gene2691	1.069e-135	442.0	COG2159@1|root,COG2159@2|Bacteria,4P1VU@976|Bacteroidetes	976|Bacteroidetes	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD2_k127_9270401_26	1449049.JONW01000005_gene1170	4.663e-128	423.0	COG2066@1|root,COG2066@2|Bacteria,1MWB5@1224|Proteobacteria,2TS8X@28211|Alphaproteobacteria,2KIYB@204458|Caulobacterales	204458|Caulobacterales	E	Glutaminase	-	-	3.5.1.2	ko:K01425	ko00220,ko00250,ko00471,ko01100,ko04724,ko04727,ko04964,ko05206,ko05230,map00220,map00250,map00471,map01100,map04724,map04727,map04964,map05206,map05230	-	R00256,R01579	RC00010,RC02798	ko00000,ko00001,ko01000	-	-	-	Glutaminase
HKD2_k127_9270401_40	1449049.JONW01000005_gene1171	7.992e-74	256.0	COG2911@1|root,COG2911@2|Bacteria,1NHQB@1224|Proteobacteria,2TZ4U@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane	-	-	-	-	-	-	-	-	-	-	-	-	Porin_2
HKD2_k127_9310446_23	1144307.PMI04_02305	4.428e-55	197.0	COG0764@1|root,COG0764@2|Bacteria,1RH2T@1224|Proteobacteria,2U7G4@28211|Alphaproteobacteria,2K4JA@204457|Sphingomonadales	204457|Sphingomonadales	I	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs	fabZ	-	4.2.1.59	ko:K02372	ko00061,ko00780,ko01100,ko01212,map00061,map00780,map01100,map01212	M00083,M00572	R04428,R04535,R04537,R04544,R04568,R04954,R04965,R07764,R10117,R10121	RC00831,RC01095	ko00000,ko00001,ko00002,ko01000,ko01004	-	-	-	FabA
HKD2_k127_9310446_26	1096930.L284_19455	3.24e-43	164.0	COG2825@1|root,COG2825@2|Bacteria,1NNT2@1224|Proteobacteria,2UM5J@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Outer membrane protein (OmpH-like)	-	-	-	-	-	-	-	-	-	-	-	-	OmpH
HKD2_k127_9310446_2	1123267.JONN01000001_gene1154	0.0	1116.0	COG4775@1|root,COG4775@2|Bacteria,1MU0D@1224|Proteobacteria,2TR7W@28211|Alphaproteobacteria,2K0GI@204457|Sphingomonadales	204457|Sphingomonadales	M	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane	bamA	-	-	ko:K07277	-	-	-	-	ko00000,ko02000,ko03029	1.B.33	-	-	Bac_surface_Ag,POTRA
HKD2_k127_9310446_12	1123267.JONN01000001_gene1153	3.148e-134	437.0	COG0750@1|root,COG0750@2|Bacteria,1MU91@1224|Proteobacteria,2TQXJ@28211|Alphaproteobacteria,2K0AZ@204457|Sphingomonadales	204457|Sphingomonadales	M	zinc metalloprotease	rseP	-	-	ko:K11749	ko02024,ko04112,map02024,map04112	-	-	-	ko00000,ko00001,ko01000,ko01002	-	-	-	PDZ,PDZ_2,Peptidase_M50
HKD2_k127_9310446_8	1335760.ASTG01000001_gene3032	5.446e-143	464.0	COG0743@1|root,COG0743@2|Bacteria,1MU4G@1224|Proteobacteria,2TSD1@28211|Alphaproteobacteria,2K0YA@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)	dxr	-	1.1.1.267	ko:K00099	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05688	RC01452	ko00000,ko00001,ko00002,ko01000	-	-	-	DXPR_C,DXP_redisom_C,DXP_reductoisom
HKD2_k127_9310446_20	1123267.JONN01000001_gene1151	1.504e-74	259.0	COG0575@1|root,COG0575@2|Bacteria,1MWSV@1224|Proteobacteria,2U9ED@28211|Alphaproteobacteria,2K1ET@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDS family	cdsA	-	2.7.7.41	ko:K00981	ko00564,ko01100,ko01110,ko04070,map00564,map01100,map01110,map04070	M00093	R01799	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	CTP_transf_1
HKD2_k127_9310446_18	1123267.JONN01000001_gene1150	3.386e-94	323.0	COG0020@1|root,COG0020@2|Bacteria,1MVP1@1224|Proteobacteria,2TTVJ@28211|Alphaproteobacteria,2K0JM@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids	uppS	-	2.5.1.31	ko:K00806	ko00900,ko01110,map00900,map01110	-	R06447	RC00279,RC02839	ko00000,ko00001,ko01000,ko01006	-	-	-	Prenyltransf
HKD2_k127_9310446_19	1120705.FG95_01548	2.631e-86	288.0	COG0233@1|root,COG0233@2|Bacteria,1N66T@1224|Proteobacteria,2U5B2@28211|Alphaproteobacteria,2K00Z@204457|Sphingomonadales	204457|Sphingomonadales	J	Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another	frr	-	-	ko:K02838	-	-	-	-	ko00000,ko03012	-	-	-	RRF
HKD2_k127_9310446_14	745310.G432_04280	3.026e-117	382.0	COG0528@1|root,COG0528@2|Bacteria,1MV3N@1224|Proteobacteria,2TQYN@28211|Alphaproteobacteria,2K1B1@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reversible phosphorylation of UMP to UDP	pyrH	-	2.7.4.22	ko:K09903	ko00240,ko01100,map00240,map01100	-	R00158	RC00002	ko00000,ko00001,ko01000	-	-	-	AA_kinase
HKD2_k127_9310446_27	1248916.ANFY01000006_gene1961	9.943e-38	162.0	COG0457@1|root,COG5616@1|root,COG0457@2|Bacteria,COG5616@2|Bacteria,1N7YB@1224|Proteobacteria,2V7CZ@28211|Alphaproteobacteria,2K2SU@204457|Sphingomonadales	204457|Sphingomonadales	S	TIR domain	-	-	-	-	-	-	-	-	-	-	-	-	TIR_2
HKD2_k127_9310446_21	1545915.JROG01000004_gene1710	4.232e-71	254.0	COG2159@1|root,COG2159@2|Bacteria,1Q704@1224|Proteobacteria,2VD3Z@28211|Alphaproteobacteria,2K7IV@204457|Sphingomonadales	204457|Sphingomonadales	S	Amidohydrolase	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_2
HKD2_k127_9310446_11	1123269.NX02_14370	2.22e-138	447.0	COG0264@1|root,COG0264@2|Bacteria,1MUS2@1224|Proteobacteria,2TQM0@28211|Alphaproteobacteria,2JZY1@204457|Sphingomonadales	204457|Sphingomonadales	J	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome	tsf	-	-	ko:K02357	-	-	-	-	ko00000,ko03012,ko03029	-	-	-	EF_TS
HKD2_k127_9310446_9	1123267.JONN01000001_gene1146	1.661e-142	454.0	COG0052@1|root,COG0052@2|Bacteria,1MU33@1224|Proteobacteria,2TRXE@28211|Alphaproteobacteria,2K0DP@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the universal ribosomal protein uS2 family	rpsB	-	-	ko:K02967	ko03010,map03010	M00178,M00179	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	Ribosomal_S2
HKD2_k127_9310446_15	1502850.FG91_03472	5.628e-111	366.0	COG1183@1|root,COG1183@2|Bacteria,1MWD9@1224|Proteobacteria,2TUF7@28211|Alphaproteobacteria,2K1B9@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pssA	-	2.7.8.8	ko:K17103	ko00260,ko00564,ko01100,ko01110,map00260,map00564,map01100,map01110	M00093	R01800	RC00002,RC00017,RC02795	ko00000,ko00001,ko00002,ko01000	-	-	-	CDP-OH_P_tran_2,CDP-OH_P_transf
HKD2_k127_9310446_16	1123267.JONN01000001_gene1184	1.385e-109	359.0	COG0688@1|root,COG0688@2|Bacteria,1MW45@1224|Proteobacteria,2TRMG@28211|Alphaproteobacteria,2K019@204457|Sphingomonadales	204457|Sphingomonadales	I	Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer)	psd	-	4.1.1.65	ko:K01613	ko00564,ko01100,ko01110,map00564,map01100,map01110	M00093	R02055	RC00299	ko00000,ko00001,ko00002,ko01000	-	-	-	PS_Dcarbxylase
HKD2_k127_9310446_3	1123267.JONN01000001_gene1183	1.407e-238	741.0	COG0538@1|root,COG0538@2|Bacteria,1MUIB@1224|Proteobacteria,2TQWD@28211|Alphaproteobacteria,2K05F@204457|Sphingomonadales	204457|Sphingomonadales	C	Belongs to the isocitrate and isopropylmalate dehydrogenases family	icd	-	1.1.1.42	ko:K00031	ko00020,ko00480,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01210,ko01230,ko04146,map00020,map00480,map00720,map01100,map01110,map01120,map01130,map01200,map01210,map01230,map04146	M00009,M00010,M00173,M00740	R00267,R00268,R01899	RC00001,RC00084,RC00114,RC00626,RC02801	br01601,ko00000,ko00001,ko00002,ko01000	-	-	-	Iso_dh
HKD2_k127_9310446_5	1112214.AHIS01000095_gene734	1.802e-201	644.0	COG0475@1|root,COG1226@1|root,COG0475@2|Bacteria,COG1226@2|Bacteria,1MV34@1224|Proteobacteria,2TRC5@28211|Alphaproteobacteria,2K061@204457|Sphingomonadales	204457|Sphingomonadales	P	Belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family	-	-	-	ko:K03455	-	-	-	-	ko00000	2.A.37	-	-	Na_H_Exchanger,TrkA_N
HKD2_k127_9310446_24	1001585.MDS_4840	1.761e-53	195.0	COG3791@1|root,COG3791@2|Bacteria,1RHWZ@1224|Proteobacteria,1S4HQ@1236|Gammaproteobacteria,1YGU8@136841|Pseudomonas aeruginosa group	1236|Gammaproteobacteria	S	Glutathione-dependent formaldehyde-activating enzyme	-	-	-	-	-	-	-	-	-	-	-	-	GFA
HKD2_k127_9310446_0	1123267.JONN01000002_gene322	0.0	1380.0	COG0013@1|root,COG0013@2|Bacteria,1MU9A@1224|Proteobacteria,2TQV4@28211|Alphaproteobacteria,2K28K@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain	alaS	-	6.1.1.7	ko:K01872	ko00970,map00970	M00359,M00360	R03038	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	DHHA1,tRNA-synt_2c,tRNA_SAD
HKD2_k127_9310446_13	1123267.JONN01000001_gene1202	4.26e-124	404.0	COG0744@1|root,COG0744@2|Bacteria,1RDAQ@1224|Proteobacteria,2U0NP@28211|Alphaproteobacteria,2K0ZN@204457|Sphingomonadales	204457|Sphingomonadales	M	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors	mtgA	-	2.4.1.129	ko:K03814	ko00550,map00550	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly
HKD2_k127_9310446_25	1123267.JONN01000001_gene1201	8.749e-52	190.0	COG5592@1|root,COG5592@2|Bacteria,1N6KG@1224|Proteobacteria,2UCBE@28211|Alphaproteobacteria,2K1MZ@204457|Sphingomonadales	204457|Sphingomonadales	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_9310446_1	1219035.NT2_02_00920	0.0	1341.0	COG0587@1|root,COG0587@2|Bacteria,1MUIF@1224|Proteobacteria,2TSCN@28211|Alphaproteobacteria,2K1R8@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase	dnaE	-	2.7.7.7	ko:K02337	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_alpha,HHH_6,PHP
HKD2_k127_9310446_17	1522072.IL54_1780	1.888e-108	355.0	COG1136@1|root,COG1136@2|Bacteria,1MVSQ@1224|Proteobacteria,2TSBE@28211|Alphaproteobacteria,2K04P@204457|Sphingomonadales	204457|Sphingomonadales	V	Part of the ABC transporter complex LolCDE involved in the translocation of lipoproteins, in an ATP-dependent manner	lolD	-	-	ko:K09810	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko01000,ko02000	3.A.1.125	-	-	ABC_tran
HKD2_k127_9310446_6	1331060.RLDS_09770	9.737e-193	608.0	COG4591@1|root,COG4591@2|Bacteria,1MVV7@1224|Proteobacteria,2TRBX@28211|Alphaproteobacteria,2K03V@204457|Sphingomonadales	204457|Sphingomonadales	M	ABC-type transport system, involved in lipoprotein release, permease component	-	-	-	ko:K09808	ko02010,map02010	M00255	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.125	-	-	FtsX,MacB_PCD
HKD2_k127_9310446_4	1123267.JONN01000001_gene1196	1.184e-237	739.0	COG0442@1|root,COG0442@2|Bacteria,1MU7E@1224|Proteobacteria,2TQQ4@28211|Alphaproteobacteria,2K181@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro)	proS	-	6.1.1.15	ko:K01881	ko00970,map00970	M00359,M00360	R03661	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	HGTP_anticodon,tRNA-synt_2b
HKD2_k127_9310446_10	1112212.JH584235_gene1643	4.116e-140	454.0	COG0626@1|root,COG0626@2|Bacteria,1MU9E@1224|Proteobacteria,2TS8Z@28211|Alphaproteobacteria,2K0WB@204457|Sphingomonadales	204457|Sphingomonadales	E	cystathionine beta-lyase	metC	-	4.4.1.8	ko:K01760	ko00270,ko00450,ko01100,ko01110,ko01230,map00270,map00450,map01100,map01110,map01230	M00017	R00782,R01286,R02408,R04941	RC00056,RC00069,RC00382,RC00488,RC00710,RC01245,RC02303	ko00000,ko00001,ko00002,ko01000	-	-	-	Cys_Met_Meta_PP
HKD2_k127_9310446_31	158500.BV97_04307	1.536e-06	51.0	COG0823@1|root,COG0823@2|Bacteria,1NJ2A@1224|Proteobacteria,2UNDP@28211|Alphaproteobacteria,2K832@204457|Sphingomonadales	204457|Sphingomonadales	U	Involved in the tonB-independent uptake of proteins	-	-	-	-	-	-	-	-	-	-	-	-	PD40
HKD2_k127_9310446_7	685778.AORL01000010_gene3051	2.195e-156	497.0	COG0604@1|root,COG0604@2|Bacteria,1MX8A@1224|Proteobacteria,2TYVX@28211|Alphaproteobacteria,2K2ZI@204457|Sphingomonadales	204457|Sphingomonadales	C	Zinc-binding dehydrogenase	-	-	-	-	-	-	-	-	-	-	-	-	ADH_N,ADH_zinc_N_2
HKD2_k127_9310446_30	378806.STAUR_6173	1.252e-09	70.0	COG1404@1|root,COG3291@1|root,COG1404@2|Bacteria,COG3291@2|Bacteria,1MU3S@1224|Proteobacteria,42SPI@68525|delta/epsilon subdivisions,2X5HM@28221|Deltaproteobacteria	68525|delta/epsilon subdivisions	O	Peptidase inhibitor I9	-	-	3.4.21.111	ko:K20754	-	-	-	-	ko00000,ko01000,ko01002	-	-	-	Inhibitor_I9,Peptidase_S8
HKD2_k127_9310446_28	1502851.FG93_04886	9.784e-30	122.0	COG3093@1|root,COG3093@2|Bacteria,1N6H7@1224|Proteobacteria,2UBSK@28211|Alphaproteobacteria,3K0TW@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	K	Helix-turn-helix	-	-	-	ko:K21498	-	-	-	-	ko00000,ko02048	-	-	-	HTH_3
HKD2_k127_9310446_29	1248760.ANFZ01000002_gene3214	4.539e-16	78.0	COG3549@1|root,COG3549@2|Bacteria,1MZ4I@1224|Proteobacteria,2UD9W@28211|Alphaproteobacteria,2K621@204457|Sphingomonadales	204457|Sphingomonadales	S	RelE-like toxin of type II toxin-antitoxin system HigB	-	-	-	-	-	-	-	-	-	-	-	-	HigB-like_toxin
HKD2_k127_9331086_1	1430440.MGMSRv2_3776	3.242e-36	138.0	COG2963@1|root,COG2963@2|Bacteria,1MZ3D@1224|Proteobacteria,2UBSS@28211|Alphaproteobacteria,2JZNB@204441|Rhodospirillales	28211|Alphaproteobacteria	L	Transposase	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_Tnp_1
HKD2_k127_9331086_0	288000.BBta_7691	1.438e-164	522.0	COG2801@1|root,COG2801@2|Bacteria,1MVN5@1224|Proteobacteria,2TQK0@28211|Alphaproteobacteria,3JURJ@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	L	Integrase core domain	-	-	-	ko:K07497	-	-	-	-	ko00000	-	-	-	HTH_21,rve,rve_3
HKD2_k127_9342622_10	1219049.SP5_035_00510	1.477e-20	92.0	COG1514@1|root,COG1514@2|Bacteria,1RDB2@1224|Proteobacteria,2U7FV@28211|Alphaproteobacteria,2K3F8@204457|Sphingomonadales	204457|Sphingomonadales	J	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester	-	-	3.1.4.58	ko:K01975	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	LigT_PEase
HKD2_k127_9342622_9	1123237.Salmuc_02630	3.023e-22	113.0	COG0210@1|root,COG4916@1|root,COG0210@2|Bacteria,COG4916@2|Bacteria,1MXSI@1224|Proteobacteria,2UB5P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD
HKD2_k127_9342622_5	1123267.JONN01000001_gene1705	1.15e-77	287.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1NCCW@1224|Proteobacteria,2UGC8@28211|Alphaproteobacteria,2K3I7@204457|Sphingomonadales	204457|Sphingomonadales	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HKD2_k127_9342622_1	392499.Swit_3144	3.768e-263	856.0	COG1629@1|root,COG1629@2|Bacteria,COG4771@2|Bacteria,1MU9K@1224|Proteobacteria,2TTJG@28211|Alphaproteobacteria,2JZUI@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_9342622_8	1123237.Salmuc_02630	1.82e-22	114.0	COG0210@1|root,COG4916@1|root,COG0210@2|Bacteria,COG4916@2|Bacteria,1MXSI@1224|Proteobacteria,2UB5P@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	DNA helicase	-	-	-	-	-	-	-	-	-	-	-	-	AAA_19,NERD
HKD2_k127_9342622_6	1123267.JONN01000001_gene1705	6.292e-68	258.0	COG0457@1|root,COG3629@1|root,COG5616@1|root,COG0457@2|Bacteria,COG3629@2|Bacteria,COG5616@2|Bacteria,1NCCW@1224|Proteobacteria,2UGC8@28211|Alphaproteobacteria,2K3I7@204457|Sphingomonadales	204457|Sphingomonadales	T	Bacterial transcriptional activator domain	-	-	-	-	-	-	-	-	-	-	-	-	BTAD
HKD2_k127_9342622_4	158500.BV97_02672	3.185e-114	374.0	COG2326@1|root,COG2326@2|Bacteria,1MVE2@1224|Proteobacteria,2TSU8@28211|Alphaproteobacteria,2K0KF@204457|Sphingomonadales	204457|Sphingomonadales	S	Polyphosphate kinase 2 (PPK2)	ppk2	-	2.7.4.1	ko:K22468	ko00190,ko03018,map00190,map03018	-	-	-	ko00000,ko00001,ko01000,ko03019	-	-	-	PPK2
HKD2_k127_9342622_7	161528.ED21_20779	9.911e-59	212.0	2FGC9@1|root,3488G@2|Bacteria	2|Bacteria	S	Domain of unknown function (DUF4956)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4956
HKD2_k127_9342622_3	1123267.JONN01000001_gene466	1.05e-146	467.0	COG0207@1|root,COG0207@2|Bacteria,1MUBD@1224|Proteobacteria,2TQSB@28211|Alphaproteobacteria,2K0PF@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis	thyA	-	2.1.1.45	ko:K00560	ko00240,ko00670,ko01100,ko01523,map00240,map00670,map01100,map01523	M00053	R02101	RC00219,RC00332	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylat_synt
HKD2_k127_9342622_0	1123267.JONN01000001_gene1627	0.0	2557.0	COG0086@1|root,COG0086@2|Bacteria,1MU3M@1224|Proteobacteria,2TRHV@28211|Alphaproteobacteria,2K1CM@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoC	-	2.7.7.6	ko:K03046	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb1_1,RNA_pol_Rpb1_2,RNA_pol_Rpb1_3,RNA_pol_Rpb1_4,RNA_pol_Rpb1_5
HKD2_k127_9342622_2	1123267.JONN01000001_gene1626	2.556e-252	783.0	COG0085@1|root,COG0085@2|Bacteria,1MUC4@1224|Proteobacteria,2TS7S@28211|Alphaproteobacteria,2JZWE@204457|Sphingomonadales	204457|Sphingomonadales	K	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates	rpoB	-	2.7.7.6	ko:K03043	ko00230,ko00240,ko01100,ko03020,map00230,map00240,map01100,map03020	M00183	R00435,R00441,R00442,R00443	RC02795	br01611,ko00000,ko00001,ko00002,ko01000,ko03021,ko03400	-	-	-	RNA_pol_Rpb2_1,RNA_pol_Rpb2_2,RNA_pol_Rpb2_3,RNA_pol_Rpb2_45,RNA_pol_Rpb2_6,RNA_pol_Rpb2_7
HKD2_k127_9655635_1	1057002.KB905370_gene2611	2.383e-96	326.0	COG0457@1|root,COG2114@1|root,COG5616@1|root,COG0457@2|Bacteria,COG2114@2|Bacteria,COG5616@2|Bacteria,1MUMZ@1224|Proteobacteria,2TRUI@28211|Alphaproteobacteria,4B9BA@82115|Rhizobiaceae	28211|Alphaproteobacteria	T	Adenylate cyclase	-	-	-	-	-	-	-	-	-	-	-	-	Guanylate_cyc,TPR_8
HKD2_k127_9655635_3	1247963.JPHU01000025_gene1553	4.93e-29	121.0	COG4319@1|root,COG4319@2|Bacteria	2|Bacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	DUF4440,SnoaL_3
HKD2_k127_9655635_0	765911.Thivi_3555	6.527e-144	470.0	COG4664@1|root,COG4664@2|Bacteria,1R4MZ@1224|Proteobacteria,1RMR6@1236|Gammaproteobacteria,1WWHM@135613|Chromatiales	135613|Chromatiales	Q	TRAP C4-dicarboxylate transport system permease DctM subunit	-	-	-	-	-	-	-	-	-	-	-	-	DctM
HKD2_k127_9655635_2	1122963.AUHB01000014_gene4216	4.892e-34	138.0	COG4665@1|root,COG4665@2|Bacteria,1RHBW@1224|Proteobacteria,2TT9A@28211|Alphaproteobacteria,370BI@31993|Methylocystaceae	28211|Alphaproteobacteria	Q	Tripartite ATP-independent periplasmic transporters, DctQ component	-	-	-	-	-	-	-	-	-	-	-	-	DctQ
HKD2_k127_9788736_32	1304878.AUGD01000002_gene1614	0.0001198	51.0	COG0457@1|root,COG3914@1|root,COG0457@2|Bacteria,COG3914@2|Bacteria,1MVMG@1224|Proteobacteria,2TRVB@28211|Alphaproteobacteria,3JTIK@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Glycosyl transferase family 41	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_transf_41,TPR_1,TPR_16,TPR_19,TPR_2,TPR_8
HKD2_k127_9788736_27	765698.Mesci_2722	4.816e-45	169.0	COG3829@1|root,COG3920@1|root,COG3829@2|Bacteria,COG3920@2|Bacteria,1NU8D@1224|Proteobacteria,2V7EJ@28211|Alphaproteobacteria,43JVA@69277|Phyllobacteriaceae	28211|Alphaproteobacteria	T	PAS domain	-	-	-	-	-	-	-	-	-	-	-	-	HWE_HK,PAS,PAS_4,PAS_9
HKD2_k127_9788736_15	1123267.JONN01000001_gene1206	1.849e-103	343.0	COG1432@1|root,COG1432@2|Bacteria,1MX5C@1224|Proteobacteria,2TRE6@28211|Alphaproteobacteria,2K1CX@204457|Sphingomonadales	204457|Sphingomonadales	S	OST-HTH/LOTUS domain	-	-	-	-	-	-	-	-	-	-	-	-	NYN,OST-HTH
HKD2_k127_9788736_30	1123267.JONN01000001_gene1208	2.893e-26	112.0	2DTUP@1|root,33MQD@2|Bacteria,1NPP7@1224|Proteobacteria,2UX90@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	Gly-zipper_Omp
HKD2_k127_9788736_19	745310.G432_01120	1.572e-81	276.0	COG0288@1|root,COG0288@2|Bacteria,1NGFN@1224|Proteobacteria,2TRPD@28211|Alphaproteobacteria,2K1U7@204457|Sphingomonadales	204457|Sphingomonadales	P	Reversible hydration of carbon dioxide	-	-	4.2.1.1	ko:K01673	ko00910,map00910	-	R00132,R10092	RC02807	ko00000,ko00001,ko01000	-	-	-	Pro_CA
HKD2_k127_9788736_8	1123269.NX02_10350	4.533e-167	534.0	COG0320@1|root,COG0320@2|Bacteria,1MVRD@1224|Proteobacteria,2TRP3@28211|Alphaproteobacteria,2K1H4@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives	lipA	-	2.8.1.8	ko:K03644	ko00785,ko01100,map00785,map01100	-	R07767,R07768	RC01978	ko00000,ko00001,ko01000	-	-	-	LIAS_N,Radical_SAM
HKD2_k127_9788736_29	1537715.JQFJ01000002_gene561	4.503e-40	157.0	COG2867@1|root,COG2867@2|Bacteria,1RGUH@1224|Proteobacteria,2U7D8@28211|Alphaproteobacteria,2K41W@204457|Sphingomonadales	204457|Sphingomonadales	I	Oligoketide cyclase lipid transport protein	-	-	-	ko:K18588	-	-	-	-	ko00000	-	-	-	Polyketide_cyc
HKD2_k127_9788736_21	1090319.KE386571_gene2385	3.168e-67	237.0	COG1546@1|root,COG1546@2|Bacteria,1RH2Y@1224|Proteobacteria,2U94H@28211|Alphaproteobacteria,2K40Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Belongs to the CinA family	-	-	3.5.1.42	ko:K03743	ko00760,map00760	-	R02322	RC00100	ko00000,ko00001,ko01000	-	-	-	CinA
HKD2_k127_9788736_10	1123267.JONN01000001_gene1212	1.12e-139	453.0	COG0245@1|root,COG1211@1|root,COG0245@2|Bacteria,COG1211@2|Bacteria,1MVHA@1224|Proteobacteria,2TRQC@28211|Alphaproteobacteria,2K0Y0@204457|Sphingomonadales	204457|Sphingomonadales	I	Bifunctional enzyme that catalyzes the formation of 4- diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl- D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2- phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4- cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF)	ispDF	-	2.7.7.60,4.6.1.12	ko:K12506	ko00900,ko01100,ko01110,ko01130,map00900,map01100,map01110,map01130	M00096	R05633,R05637	RC00002,RC01440	ko00000,ko00001,ko00002,ko01000	-	-	-	IspD,YgbB
HKD2_k127_9788736_9	1123267.JONN01000001_gene1213	1.663e-166	544.0	COG0042@1|root,COG0042@2|Bacteria,1MV5V@1224|Proteobacteria,2TRC8@28211|Alphaproteobacteria,2K0QH@204457|Sphingomonadales	204457|Sphingomonadales	J	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines	-	-	-	ko:K05540	-	-	-	-	ko00000,ko01000,ko03016	-	-	-	Dus
HKD2_k127_9788736_0	1123267.JONN01000001_gene1214	1.822e-299	935.0	COG5000@1|root,COG5000@2|Bacteria,1MWKZ@1224|Proteobacteria,2TQTB@28211|Alphaproteobacteria,2K01N@204457|Sphingomonadales	204457|Sphingomonadales	T	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation	ntrY	-	2.7.13.3	ko:K13598	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko01000,ko01001,ko02022	-	-	-	HAMP,HATPase_c,HisKA,PAS,PAS_4
HKD2_k127_9788736_2	1123267.JONN01000001_gene1215	1.568e-233	728.0	COG2204@1|root,COG2204@2|Bacteria,1MU0N@1224|Proteobacteria,2TQW2@28211|Alphaproteobacteria,2K1KM@204457|Sphingomonadales	204457|Sphingomonadales	T	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains	ntrX	-	-	ko:K13599	ko02020,map02020	M00498	-	-	ko00000,ko00001,ko00002,ko02022	-	-	-	HTH_8,Response_reg,Sigma54_activat
HKD2_k127_9788736_23	1123267.JONN01000001_gene1216	2.302e-59	209.0	COG1923@1|root,COG1923@2|Bacteria,1MZM1@1224|Proteobacteria,2UBTW@28211|Alphaproteobacteria,2K2YT@204457|Sphingomonadales	204457|Sphingomonadales	J	RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs	hfq	-	-	ko:K03666	ko02024,ko03018,ko05111,map02024,map03018,map05111	-	-	-	ko00000,ko00001,ko03019,ko03036	-	-	-	Hfq
HKD2_k127_9788736_5	1123267.JONN01000001_gene1217	7.737e-189	598.0	COG2262@1|root,COG2262@2|Bacteria,1MUA0@1224|Proteobacteria,2TUXJ@28211|Alphaproteobacteria,2K0SI@204457|Sphingomonadales	204457|Sphingomonadales	S	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis	hflX	-	-	ko:K03665	-	-	-	-	ko00000,ko03009	-	-	-	GTP-bdg_M,GTP-bdg_N,MMR_HSR1
HKD2_k127_9788736_16	1123267.JONN01000002_gene365	5.109e-98	326.0	COG1694@1|root,COG3956@2|Bacteria,1MVKM@1224|Proteobacteria,2TRC9@28211|Alphaproteobacteria,2K0DA@204457|Sphingomonadales	204457|Sphingomonadales	S	MazG family	mazG	-	3.6.1.9	ko:K04765	ko00230,ko00240,ko00760,ko00770,ko01100,map00230,map00240,map00760,map00770,map01100	-	R00086,R00087,R00103,R00287,R00426,R00515,R00662,R00720,R03004,R03036,R11323	RC00002	ko00000,ko00001,ko01000	-	-	-	MazG
HKD2_k127_9788736_20	1123267.JONN01000002_gene364	1.212e-68	238.0	COG3577@1|root,COG3577@2|Bacteria,1R74B@1224|Proteobacteria,2UBEE@28211|Alphaproteobacteria,2K1P8@204457|Sphingomonadales	204457|Sphingomonadales	S	gag-polyprotein putative aspartyl protease	-	-	-	ko:K06985	ko04112,map04112	-	-	-	ko00000,ko00001	-	-	-	gag-asp_proteas
HKD2_k127_9788736_17	1123267.JONN01000002_gene362	8.264e-98	326.0	COG1235@1|root,COG1235@2|Bacteria,1MVJH@1224|Proteobacteria,2TQQN@28211|Alphaproteobacteria,2K1KQ@204457|Sphingomonadales	204457|Sphingomonadales	S	COG1235 Metal-dependent hydrolases of the beta-lactamase superfamily I	-	-	3.1.4.55	ko:K06167	ko00440,map00440	-	R10205	RC00296	ko00000,ko00001,ko01000	-	-	-	Lactamase_B_2
HKD2_k127_9788736_12	1123267.JONN01000002_gene361	6.679e-118	386.0	COG0084@1|root,COG0084@2|Bacteria,1MUC0@1224|Proteobacteria,2TS88@28211|Alphaproteobacteria,2K0X6@204457|Sphingomonadales	204457|Sphingomonadales	L	LuxR family transcriptional regulator	-	-	-	ko:K03424	-	-	-	-	ko00000,ko01000	-	-	-	TatD_DNase
HKD2_k127_9788736_1	1123267.JONN01000002_gene360	6.563e-256	796.0	COG0143@1|root,COG0143@2|Bacteria,1MUBY@1224|Proteobacteria,2TQKA@28211|Alphaproteobacteria,2K0VF@204457|Sphingomonadales	204457|Sphingomonadales	J	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation	metG	-	6.1.1.10	ko:K01874	ko00450,ko00970,map00450,map00970	M00359,M00360	R03659,R04773	RC00055,RC00523	ko00000,ko00001,ko00002,ko01000,ko01007,ko03016	-	-	-	Anticodon_1,tRNA-synt_1g
HKD2_k127_9788736_14	1123267.JONN01000002_gene359	3.849e-105	351.0	COG0470@1|root,COG0470@2|Bacteria,1MY1W@1224|Proteobacteria,2TV3E@28211|Alphaproteobacteria,2JZZA@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA polymerase	holB	-	2.7.7.7	ko:K02341	ko00230,ko00240,ko01100,ko03030,ko03430,ko03440,map00230,map00240,map01100,map03030,map03430,map03440	M00260	R00375,R00376,R00377,R00378	RC02795	ko00000,ko00001,ko00002,ko01000,ko03032,ko03400	-	-	-	DNA_pol3_delta2
HKD2_k127_9788736_18	1123267.JONN01000002_gene358	4.18e-86	289.0	COG0125@1|root,COG0125@2|Bacteria,1MV9C@1224|Proteobacteria,2U72D@28211|Alphaproteobacteria,2K3VU@204457|Sphingomonadales	204457|Sphingomonadales	F	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis	tmk	-	2.7.4.9	ko:K00943	ko00240,ko01100,map00240,map01100	M00053	R02094,R02098	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Thymidylate_kin
HKD2_k127_9788736_6	1123267.JONN01000002_gene357	1.368e-175	557.0	COG1686@1|root,COG1686@2|Bacteria,1MUU7@1224|Proteobacteria,2TS1P@28211|Alphaproteobacteria,2K17Y@204457|Sphingomonadales	204457|Sphingomonadales	M	Belongs to the peptidase S11 family	dac	-	3.4.16.4	ko:K07258	ko00550,ko01100,map00550,map01100	-	-	-	ko00000,ko00001,ko01000,ko01002,ko01011	-	-	-	PBP5_C,Peptidase_S11
HKD2_k127_9788736_11	1123267.JONN01000002_gene356	2.025e-121	399.0	COG2951@1|root,COG2951@2|Bacteria,1MUZ3@1224|Proteobacteria,2TRP0@28211|Alphaproteobacteria,2K0TV@204457|Sphingomonadales	204457|Sphingomonadales	M	Lytic murein transglycosylase	mltB	-	-	-	-	-	-	-	-	-	-	-	SLT_2
HKD2_k127_9788736_25	1144307.PMI04_02525	2.12e-49	186.0	2DNBN@1|root,32WN2@2|Bacteria,1N5BF@1224|Proteobacteria	1224|Proteobacteria	S	Protein of unknown function (DUF3313)	-	-	-	-	-	-	-	-	-	-	-	-	DUF3313
HKD2_k127_9788736_26	1123267.JONN01000001_gene730	4.488e-47	171.0	COG3682@1|root,COG3682@2|Bacteria,1N95N@1224|Proteobacteria,2UISP@28211|Alphaproteobacteria,2K5C7@204457|Sphingomonadales	204457|Sphingomonadales	K	Penicillinase repressor	-	-	-	-	-	-	-	-	-	-	-	-	Penicillinase_R
HKD2_k127_9788736_13	1123267.JONN01000001_gene729	8.936e-118	402.0	COG4219@1|root,COG4219@2|Bacteria,1N96C@1224|Proteobacteria,2UI6V@28211|Alphaproteobacteria,2K34J@204457|Sphingomonadales	204457|Sphingomonadales	KT	BlaR1 peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	Peptidase_M56
HKD2_k127_9788736_24	1123267.JONN01000001_gene728	2.177e-54	201.0	COG4219@1|root,COG4219@2|Bacteria,1P0K4@1224|Proteobacteria,2UVBF@28211|Alphaproteobacteria,2K7R8@204457|Sphingomonadales	204457|Sphingomonadales	KT	Peptidase M56	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9788736_3	1123267.JONN01000002_gene355	7.594e-221	708.0	COG1629@1|root,COG4771@2|Bacteria,1R0WC@1224|Proteobacteria,2U1A6@28211|Alphaproteobacteria,2KE9F@204457|Sphingomonadales	204457|Sphingomonadales	P	COG1629 Outer membrane receptor proteins, mostly Fe transport	-	-	-	-	-	-	-	-	-	-	-	-	Plug,TonB_dep_Rec
HKD2_k127_9788736_4	1123267.JONN01000002_gene354	2.522e-217	681.0	COG1960@1|root,COG1960@2|Bacteria,1MUK0@1224|Proteobacteria,2TSAC@28211|Alphaproteobacteria,2K030@204457|Sphingomonadales	204457|Sphingomonadales	I	acyl-CoA dehydrogenase	-	-	1.3.8.6	ko:K00252	ko00071,ko00310,ko00362,ko00380,ko01100,ko01120,ko01130,map00071,map00310,map00362,map00380,map01100,map01120,map01130	M00032	R02487,R02488,R10074	RC00052,RC00156	ko00000,ko00001,ko00002,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9788736_22	392499.Swit_4520	4.086e-66	231.0	COG1704@1|root,COG1704@2|Bacteria,1MVH0@1224|Proteobacteria,2U6EM@28211|Alphaproteobacteria,2K6NB@204457|Sphingomonadales	204457|Sphingomonadales	S	LemA family	-	-	-	ko:K03744	-	-	-	-	ko00000	-	-	-	LemA
HKD2_k127_9788736_7	392499.Swit_4521	5.989e-168	548.0	COG4907@1|root,COG4907@2|Bacteria,1MXPY@1224|Proteobacteria,2TUBP@28211|Alphaproteobacteria	28211|Alphaproteobacteria	S	Predicted membrane protein (DUF2207)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2207
HKD2_k127_9788736_28	1229485.AMYV01000013_gene385	4.528e-41	158.0	COG1670@1|root,COG1670@2|Bacteria,1RCX2@1224|Proteobacteria,1S42B@1236|Gammaproteobacteria,1J7E3@118884|unclassified Gammaproteobacteria	1236|Gammaproteobacteria	J	Acetyltransferase (GNAT) domain	-	-	-	-	-	-	-	-	-	-	-	-	Acetyltransf_3
HKD2_k127_9815420_10	1081640.AGFU01000042_gene3195	1.163e-48	184.0	2C130@1|root,32R80@2|Bacteria,1RDSY@1224|Proteobacteria,2U84Y@28211|Alphaproteobacteria,2KEWC@204457|Sphingomonadales	204457|Sphingomonadales	S	Putative MetA-pathway of phenol degradation	-	-	-	-	-	-	-	-	-	-	-	-	Phenol_MetA_deg
HKD2_k127_9815420_0	1123267.JONN01000001_gene1960	0.0	1138.0	COG0209@1|root,COG0209@2|Bacteria,1MUJ8@1224|Proteobacteria,2TS19@28211|Alphaproteobacteria,2K0F8@204457|Sphingomonadales	204457|Sphingomonadales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdA	-	1.17.4.1	ko:K00525	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_lgC,Ribonuc_red_lgN
HKD2_k127_9815420_12	1449076.JOOE01000003_gene3316	1.3e-33	132.0	2EG8Z@1|root,33A0S@2|Bacteria,1NKBI@1224|Proteobacteria,2UN0S@28211|Alphaproteobacteria,2K67X@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9815420_2	685778.AORL01000009_gene3265	1.503e-213	665.0	COG0208@1|root,COG0208@2|Bacteria,1MWUS@1224|Proteobacteria,2TS3X@28211|Alphaproteobacteria,2K1H7@204457|Sphingomonadales	204457|Sphingomonadales	F	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides	nrdB	-	1.17.4.1	ko:K00526	ko00230,ko00240,ko01100,map00230,map00240,map01100	M00053	R02017,R02018,R02019,R02024	RC00613	ko00000,ko00001,ko00002,ko01000,ko03400	-	-	-	Ribonuc_red_sm
HKD2_k127_9815420_11	279238.Saro_3152	3.582e-43	161.0	2D8VC@1|root,32TS1@2|Bacteria,1MZWT@1224|Proteobacteria,2UEVN@28211|Alphaproteobacteria	28211|Alphaproteobacteria	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9815420_18	1082931.KKY_2741	3.142e-09	65.0	COG1525@1|root,COG1525@2|Bacteria,1MZNP@1224|Proteobacteria,2UCTJ@28211|Alphaproteobacteria	28211|Alphaproteobacteria	L	nuclease	-	-	-	-	-	-	-	-	-	-	-	-	SNase
HKD2_k127_9815420_13	1123267.JONN01000001_gene1946	7.671e-31	126.0	COG3798@1|root,COG3798@2|Bacteria,1N2FJ@1224|Proteobacteria,2UC84@28211|Alphaproteobacteria,2K6QA@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized protein conserved in bacteria (DUF2171)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2171
HKD2_k127_9815420_1	1123269.NX02_26025	0.0	1104.0	COG0308@1|root,COG0308@2|Bacteria,1MUCI@1224|Proteobacteria,2TRUM@28211|Alphaproteobacteria,2K072@204457|Sphingomonadales	204457|Sphingomonadales	E	aminopeptidase N	pepN	-	3.4.11.2	ko:K01256	ko00480,ko01100,map00480,map01100	-	R00899,R04951	RC00096,RC00141	ko00000,ko00001,ko01000,ko01002	-	-	-	DUF3458,DUF3458_C,Peptidase_M1
HKD2_k127_9815420_14	983545.Glaag_2950	2.564e-29	123.0	COG0662@1|root,COG0662@2|Bacteria,1QX05@1224|Proteobacteria,1T31V@1236|Gammaproteobacteria,46D37@72275|Alteromonadaceae	1236|Gammaproteobacteria	G	Cupin domain	-	-	-	-	-	-	-	-	-	-	-	-	Cupin_2
HKD2_k127_9815420_9	1123267.JONN01000001_gene1871	9.132e-51	189.0	COG3218@1|root,COG3218@2|Bacteria,1RKTW@1224|Proteobacteria,2UAXY@28211|Alphaproteobacteria,2K5KR@204457|Sphingomonadales	204457|Sphingomonadales	S	transport system auxiliary component	linN	-	-	ko:K18480	-	M00669	-	-	ko00000,ko00002,ko02000	3.A.1.27.1	-	-	ABC_trans_aux
HKD2_k127_9815420_5	1123267.JONN01000001_gene1872	7.335e-134	433.0	COG1463@1|root,COG1463@2|Bacteria,1MU4B@1224|Proteobacteria,2U1JN@28211|Alphaproteobacteria,2K12E@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, periplasmic component	-	-	-	ko:K02067	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaD
HKD2_k127_9815420_6	392499.Swit_2743	1.625e-123	411.0	COG1127@1|root,COG1127@2|Bacteria,1MUSD@1224|Proteobacteria,2TR2I@28211|Alphaproteobacteria,2K11G@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, ATPase component	-	-	-	ko:K02065	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	ABC_tran
HKD2_k127_9815420_3	1123267.JONN01000001_gene1874	3.22e-161	515.0	COG0767@1|root,COG0767@2|Bacteria,1MVPN@1224|Proteobacteria,2TSGS@28211|Alphaproteobacteria,2K10W@204457|Sphingomonadales	204457|Sphingomonadales	Q	ABC-type transport system involved in resistance to organic solvents, permease component	-	-	-	ko:K02066	ko02010,map02010	M00210,M00669,M00670	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.27	-	-	MlaE
HKD2_k127_9815420_4	1123267.JONN01000001_gene1875	2.951e-138	449.0	COG0558@1|root,COG0558@2|Bacteria,1MYE7@1224|Proteobacteria,2TSMC@28211|Alphaproteobacteria,2K2MN@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	-	-	-	-	-	-	-	-	-	-	-	-	CDP-OH_P_transf
HKD2_k127_9815420_8	1123267.JONN01000001_gene1876	2.087e-74	268.0	COG0746@1|root,COG0746@2|Bacteria,1QWF1@1224|Proteobacteria,2TXF5@28211|Alphaproteobacteria,2KEHV@204457|Sphingomonadales	204457|Sphingomonadales	H	MobA-like NTP transferase domain	-	-	-	-	-	-	-	-	-	-	-	-	NTP_transf_3
HKD2_k127_9815420_7	1123267.JONN01000001_gene1877	1.387e-104	345.0	COG0560@1|root,COG0560@2|Bacteria,1P4TB@1224|Proteobacteria,2UHTZ@28211|Alphaproteobacteria,2K3BN@204457|Sphingomonadales	204457|Sphingomonadales	E	haloacid dehalogenase-like hydrolase	-	-	-	-	-	-	-	-	-	-	-	-	HAD
HKD2_k127_9815420_16	1216967.L100_10999	3.7e-13	76.0	COG4922@1|root,COG4922@2|Bacteria,4NNH5@976|Bacteroidetes,1I23M@117743|Flavobacteriia,34RF3@308865|Elizabethkingia	976|Bacteroidetes	S	SnoaL-like polyketide cyclase	-	-	-	-	-	-	-	-	-	-	-	-	SnoaL,SnoaL_2
HKD2_k127_9853109_0	1205680.CAKO01000002_gene2169	4.706e-113	371.0	COG1804@1|root,COG1804@2|Bacteria,1MU2K@1224|Proteobacteria,2TR7Q@28211|Alphaproteobacteria,2JQKF@204441|Rhodospirillales	204441|Rhodospirillales	C	III protein, CoA-transferase family	-	-	-	-	-	-	-	-	-	-	-	-	CoA_transf_3
HKD2_k127_9853109_1	1205680.CAKO01000002_gene2168	4.353e-49	179.0	COG1960@1|root,COG1960@2|Bacteria,1MUDR@1224|Proteobacteria,2TQKE@28211|Alphaproteobacteria,2JR65@204441|Rhodospirillales	204441|Rhodospirillales	I	Acyl-CoA dehydrogenase, C-terminal domain	-	-	-	ko:K06446	ko00930,ko01100,ko01120,map00930,map01100,map01120	-	R06943	RC00052	ko00000,ko00001,ko01000	-	-	-	Acyl-CoA_dh_1,Acyl-CoA_dh_M,Acyl-CoA_dh_N
HKD2_k127_9853109_2	646529.Desaci_2712	1.722e-36	141.0	COG0410@1|root,COG0410@2|Bacteria,1TPW4@1239|Firmicutes,247PN@186801|Clostridia,260MZ@186807|Peptococcaceae	186801|Clostridia	E	PFAM ABC transporter	-	-	-	ko:K01996	ko02010,ko02024,map02010,map02024	M00237	-	-	ko00000,ko00001,ko00002,ko02000	3.A.1.4	-	-	ABC_tran
HKD2_k127_9937444_86	1123269.NX02_01525	3.947e-13	70.0	COG1430@1|root,COG1430@2|Bacteria,1MZBJ@1224|Proteobacteria,2UBSI@28211|Alphaproteobacteria,2K5JY@204457|Sphingomonadales	204457|Sphingomonadales	S	Uncharacterized ACR, COG1430	-	-	-	ko:K09005	-	-	-	-	ko00000	-	-	-	DUF192
HKD2_k127_9937444_54	1123270.ATUR01000002_gene2260	4.334e-46	171.0	COG3761@1|root,COG3761@2|Bacteria,1RHS3@1224|Proteobacteria,2U95G@28211|Alphaproteobacteria,2K5FH@204457|Sphingomonadales	204457|Sphingomonadales	C	NADH ubiquinone oxidoreductase 17.2 kD subunit	-	-	-	-	-	-	-	-	-	-	-	-	NDUFA12
HKD2_k127_9937444_85	629773.AORY01000004_gene607	6.507e-14	81.0	2ADXS@1|root,313PZ@2|Bacteria,1QD3C@1224|Proteobacteria,2VEKA@28211|Alphaproteobacteria,2K81Z@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9937444_39	1123267.JONN01000001_gene1592	5.781e-87	294.0	COG2360@1|root,COG2360@2|Bacteria,1R9W8@1224|Proteobacteria,2U59K@28211|Alphaproteobacteria,2K180@204457|Sphingomonadales	204457|Sphingomonadales	O	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine	aat	-	2.3.2.6	ko:K00684	-	-	R03813,R11443,R11444	RC00055,RC00064	ko00000,ko01000	-	-	-	Leu_Phe_trans
HKD2_k127_9937444_65	123899.JPQP01000017_gene2343	1.719e-37	143.0	COG1393@1|root,COG1393@2|Bacteria,1MZ4Z@1224|Proteobacteria,2VU05@28216|Betaproteobacteria,3T4I3@506|Alcaligenaceae	28216|Betaproteobacteria	P	ArsC family	arsC	-	1.20.4.1	ko:K00537	-	-	-	-	ko00000,ko01000	-	-	-	ArsC
HKD2_k127_9937444_30	1123267.JONN01000001_gene2393	5.075e-117	391.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K19X@204457|Sphingomonadales	204457|Sphingomonadales	S	L,D-transpeptidase catalytic domain	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_9937444_73	1123270.ATUR01000008_gene325	2.34e-24	111.0	COG0810@1|root,COG0810@2|Bacteria,1NB5F@1224|Proteobacteria,2USI1@28211|Alphaproteobacteria,2K2ZM@204457|Sphingomonadales	204457|Sphingomonadales	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_9937444_9	1112214.AHIS01000101_gene1620	2.278e-197	623.0	COG0477@1|root,COG2814@2|Bacteria,1MWKH@1224|Proteobacteria,2U0GU@28211|Alphaproteobacteria,2K459@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Sugar (and other) transporter	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1,Sugar_tr
HKD2_k127_9937444_11	1122962.AULH01000006_gene3230	6.681e-183	582.0	COG0161@1|root,COG0161@2|Bacteria,1MU2N@1224|Proteobacteria,2TQND@28211|Alphaproteobacteria,36XSE@31993|Methylocystaceae	28211|Alphaproteobacteria	H	Aminotransferase class-III	-	-	2.6.1.18	ko:K00822	ko00280,ko00410,ko00640,ko01100,map00280,map00410,map00640,map01100	-	R00907,R04187	RC00008,RC00062,RC00160	ko00000,ko00001,ko01000,ko01007	-	-	-	Aminotran_3
HKD2_k127_9937444_6	861299.J421_0633	2.22e-236	743.0	COG1574@1|root,COG1574@2|Bacteria	2|Bacteria	G	metal-dependent hydrolase with the TIM-barrel fold	-	-	-	-	-	-	-	-	-	-	-	-	Amidohydro_3
HKD2_k127_9937444_31	1419583.V466_08800	1.569e-113	390.0	COG0367@1|root,COG0367@2|Bacteria,1MW4E@1224|Proteobacteria,1RQ7D@1236|Gammaproteobacteria	1236|Gammaproteobacteria	E	asparagine synthase, glutamine-hydrolyzing	asnB	-	6.3.5.4	ko:K01953	ko00250,ko01100,ko01110,map00250,map01100,map01110	-	R00578	RC00010	ko00000,ko00001,ko01000,ko01002	-	-	-	Asn_synthase,GATase_7
HKD2_k127_9937444_5	13689.BV96_02527	1.481e-247	768.0	COG0439@1|root,COG0439@2|Bacteria,1MU4H@1224|Proteobacteria,2U25Z@28211|Alphaproteobacteria,2K11Z@204457|Sphingomonadales	204457|Sphingomonadales	I	An AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism	accC	-	6.3.4.14,6.4.1.2	ko:K01961	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04385	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Biotin_carb_C,Biotin_carb_N,CPSase_L_D2
HKD2_k127_9937444_59	1123267.JONN01000001_gene1590	1.753e-43	164.0	COG0511@1|root,COG0511@2|Bacteria,1RCXA@1224|Proteobacteria,2U93Y@28211|Alphaproteobacteria,2K5JX@204457|Sphingomonadales	204457|Sphingomonadales	I	first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA	accB	-	-	ko:K02160	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742	RC00040,RC00367	ko00000,ko00001,ko00002	-	-	-	Biotin_lipoyl
HKD2_k127_9937444_52	1041146.ATZB01000003_gene7012	1.26e-47	175.0	COG0757@1|root,COG0757@2|Bacteria,1RDDT@1224|Proteobacteria,2U9BV@28211|Alphaproteobacteria,4BE03@82115|Rhizobiaceae	28211|Alphaproteobacteria	E	Catalyzes a trans-dehydration via an enolate intermediate	aroQ	-	4.2.1.10	ko:K03786	ko00400,ko01100,ko01110,ko01130,ko01230,map00400,map01100,map01110,map01130,map01230	M00022	R03084	RC00848	ko00000,ko00001,ko00002,ko01000	-	-	-	DHquinase_II
HKD2_k127_9937444_75	314266.SKA58_05520	1.424e-23	107.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HKD2_k127_9937444_23	1090319.KE386571_gene2157	1.394e-135	434.0	COG2022@1|root,COG2022@2|Bacteria,1N0N5@1224|Proteobacteria,2TSXS@28211|Alphaproteobacteria,2K0MM@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S	thiG	-	2.8.1.10	ko:K03149	ko00730,ko01100,map00730,map01100	-	R10247	RC03096,RC03097,RC03461	ko00000,ko00001,ko01000	-	-	-	ThiG,ThiS
HKD2_k127_9937444_44	1336243.JAEA01000005_gene1559	2.903e-68	243.0	COG0500@1|root,COG2226@2|Bacteria,1NWX3@1224|Proteobacteria,2TURQ@28211|Alphaproteobacteria,1JX36@119045|Methylobacteriaceae	28211|Alphaproteobacteria	Q	ubiE/COQ5 methyltransferase family	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_9937444_43	1502851.FG93_03466	2.956e-70	245.0	COG2518@1|root,COG2518@2|Bacteria,1MXQC@1224|Proteobacteria,2TVCY@28211|Alphaproteobacteria,3K6HB@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)	pcm	-	2.1.1.77	ko:K00573	-	-	-	-	ko00000,ko01000	-	-	-	PCMT
HKD2_k127_9937444_12	450851.PHZ_c3225	1.754e-182	580.0	COG2312@1|root,COG2312@2|Bacteria,1MU2S@1224|Proteobacteria,2TY7R@28211|Alphaproteobacteria,2KHES@204458|Caulobacterales	204458|Caulobacterales	S	Erythromycin esterase	-	-	-	-	-	-	-	-	-	-	-	-	DLH,Erythro_esteras,Pribosyltran
HKD2_k127_9937444_70	237727.NAP1_00590	1.99e-27	123.0	COG0500@1|root,COG2226@2|Bacteria,1N7M1@1224|Proteobacteria	1224|Proteobacteria	Q	Pfam Methyltransferase	-	-	-	-	-	-	-	-	-	-	-	-	Methyltransf_11,Methyltransf_25
HKD2_k127_9937444_81	1437448.AZRT01000181_gene2344	2.095e-16	86.0	COG1522@1|root,COG1522@2|Bacteria,1RH53@1224|Proteobacteria,2U9NS@28211|Alphaproteobacteria,1J3TY@118882|Brucellaceae	28211|Alphaproteobacteria	K	helix_turn_helix ASNC type	-	-	-	-	-	-	-	-	-	-	-	-	AsnC_trans_reg,HTH_24,HTH_AsnC-type
HKD2_k127_9937444_3	1123267.JONN01000001_gene1585	6.064e-308	949.0	COG0028@1|root,COG0028@2|Bacteria,1MU6U@1224|Proteobacteria,2TSB1@28211|Alphaproteobacteria,2K0EY@204457|Sphingomonadales	204457|Sphingomonadales	EH	Belongs to the TPP enzyme family	-	-	2.2.1.6	ko:K01652	ko00290,ko00650,ko00660,ko00770,ko01100,ko01110,ko01130,ko01210,ko01230,map00290,map00650,map00660,map00770,map01100,map01110,map01130,map01210,map01230	M00019,M00570	R00006,R00014,R00226,R03050,R04672,R04673,R08648	RC00027,RC00106,RC01192,RC02744,RC02893	ko00000,ko00001,ko00002,ko01000	-	-	-	TPP_enzyme_C,TPP_enzyme_M,TPP_enzyme_N
HKD2_k127_9937444_7	1123267.JONN01000001_gene1668	4.97e-223	699.0	COG1012@1|root,COG1012@2|Bacteria,1MU1V@1224|Proteobacteria,2TQR1@28211|Alphaproteobacteria,2JZVD@204457|Sphingomonadales	204457|Sphingomonadales	C	belongs to the aldehyde dehydrogenase family	-	-	1.2.1.16,1.2.1.20,1.2.1.79	ko:K00135	ko00250,ko00310,ko00350,ko00650,ko00760,ko01100,ko01120,map00250,map00310,map00350,map00650,map00760,map01100,map01120	M00027	R00713,R00714,R02401	RC00080	ko00000,ko00001,ko00002,ko01000	-	-	-	Aldedh
HKD2_k127_9937444_63	1123267.JONN01000001_gene1635	6.843e-38	144.0	COG3255@1|root,COG3255@2|Bacteria,1Q4V4@1224|Proteobacteria,2VB9X@28211|Alphaproteobacteria,2K6UF@204457|Sphingomonadales	204457|Sphingomonadales	I	PFAM Sterol-binding domain protein	-	-	-	-	-	-	-	-	-	-	-	-	SCP2
HKD2_k127_9937444_78	1248917.ANFX01000029_gene2637	2.057e-21	97.0	COG3602@1|root,COG3602@2|Bacteria,1MZKQ@1224|Proteobacteria,2U85U@28211|Alphaproteobacteria,2KDC5@204457|Sphingomonadales	204457|Sphingomonadales	S	ACT domain	-	-	-	-	-	-	-	-	-	-	-	-	ACT_3,ACT_7
HKD2_k127_9937444_56	460265.Mnod_2859	2.724e-45	171.0	COG0625@1|root,COG0625@2|Bacteria,1MWUG@1224|Proteobacteria,2TTZ6@28211|Alphaproteobacteria,1JSP3@119045|Methylobacteriaceae	28211|Alphaproteobacteria	O	PFAM Glutathione S-transferase domain	-	-	2.5.1.18	ko:K00799	ko00480,ko00980,ko00982,ko00983,ko01524,ko05200,ko05204,ko05225,ko05418,map00480,map00980,map00982,map00983,map01524,map05200,map05204,map05225,map05418	-	R03522,R07002,R07003,R07004,R07023,R07024,R07025,R07026,R07069,R07070,R07083,R07084,R07091,R07092,R07093,R07094,R07100,R07113,R07116,R08280,R09409,R11905	RC00004,RC00069,RC00840,RC00948,RC01704,RC01705,RC01706,RC01758,RC01759,RC01765,RC01767,RC01769,RC02243,RC02527,RC02939,RC02940,RC02942,RC02943,RC02944	ko00000,ko00001,ko01000,ko02000	1.A.12.2.2,1.A.12.3.2	-	-	GST_C,GST_N,GST_N_3
HKD2_k127_9937444_25	1030157.AFMP01000065_gene1164	2.228e-133	427.0	COG1788@1|root,COG1788@2|Bacteria,1MVEI@1224|Proteobacteria,2TTE6@28211|Alphaproteobacteria,2K0EF@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit	scoA	-	2.8.3.5	ko:K01028	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_9937444_29	279238.Saro_0566	3.726e-120	395.0	COG2057@1|root,COG2057@2|Bacteria,1RA4V@1224|Proteobacteria,2TQS5@28211|Alphaproteobacteria,2JZXA@204457|Sphingomonadales	204457|Sphingomonadales	I	Acyl CoA acetate 3-ketoacid CoA transferase, beta subunit	scoB	-	2.8.3.5	ko:K01029	ko00072,ko00280,ko00650,map00072,map00280,map00650	-	R00410	RC00014	ko00000,ko00001,ko01000	-	-	-	CoA_trans
HKD2_k127_9937444_18	1123267.JONN01000001_gene1643	6.048e-144	463.0	COG0604@1|root,COG0604@2|Bacteria,1MWRK@1224|Proteobacteria,2TQMF@28211|Alphaproteobacteria,2K1HA@204457|Sphingomonadales	204457|Sphingomonadales	C	COG0604 NADPH quinone reductase and related Zn-dependent oxidoreductases	-	-	1.6.5.5	ko:K00344	-	-	-	-	ko00000,ko01000	-	-	-	ADH_N,ADH_zinc_N
HKD2_k127_9937444_77	1449076.JOOE01000003_gene3366	1.585e-21	108.0	2DRS8@1|root,33CUB@2|Bacteria,1QV1W@1224|Proteobacteria,2UJDK@28211|Alphaproteobacteria,2KERH@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9937444_66	1123269.NX02_05830	5.86e-36	141.0	COG5467@1|root,COG5467@2|Bacteria,1MZRN@1224|Proteobacteria,2UC1G@28211|Alphaproteobacteria,2K533@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF1476)	-	-	-	-	-	-	-	-	-	-	-	-	DUF1476
HKD2_k127_9937444_68	1550073.JROH01000027_gene941	5.55e-31	124.0	COG0271@1|root,COG0271@2|Bacteria,1R3MM@1224|Proteobacteria,2UBUW@28211|Alphaproteobacteria,2K5YQ@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the BolA IbaG family	-	-	-	-	-	-	-	-	-	-	-	-	BolA
HKD2_k127_9937444_51	1123267.JONN01000001_gene1647	1.383e-49	177.0	COG0278@1|root,COG0278@2|Bacteria,1MZ4V@1224|Proteobacteria,2U9QB@28211|Alphaproteobacteria,2K55Y@204457|Sphingomonadales	204457|Sphingomonadales	O	Belongs to the glutaredoxin family. Monothiol subfamily	grxD	-	-	ko:K07390	-	-	-	-	ko00000,ko03029,ko03110	-	-	-	Glutaredoxin
HKD2_k127_9937444_16	1123267.JONN01000001_gene1648	1.178e-149	484.0	COG0438@1|root,COG0438@2|Bacteria,1NU0D@1224|Proteobacteria,2U2M4@28211|Alphaproteobacteria,2K040@204457|Sphingomonadales	204457|Sphingomonadales	M	Glycosyltransferase Family 4	-	-	-	-	-	-	-	-	-	-	-	-	Glyco_trans_1_4,Glyco_transf_4
HKD2_k127_9937444_33	1449076.JOOE01000002_gene1289	2.431e-107	358.0	COG0491@1|root,COG0491@2|Bacteria,1MVC3@1224|Proteobacteria,2TUAZ@28211|Alphaproteobacteria,2K18T@204457|Sphingomonadales	204457|Sphingomonadales	S	COG0491 Zn-dependent hydrolases, including glyoxylases	-	-	-	-	-	-	-	-	-	-	-	-	Lactamase_B
HKD2_k127_9937444_50	1007104.SUS17_2615	4.262e-54	198.0	2BX8M@1|root,31H0R@2|Bacteria,1MYMI@1224|Proteobacteria,2UB1B@28211|Alphaproteobacteria,2K27Q@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF4230)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4230
HKD2_k127_9937444_10	1123267.JONN01000001_gene1653	2.715e-197	618.0	COG0379@1|root,COG0379@2|Bacteria,1MWQU@1224|Proteobacteria,2TRPG@28211|Alphaproteobacteria,2K13Q@204457|Sphingomonadales	204457|Sphingomonadales	H	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate	nadA	-	2.5.1.72	ko:K03517	ko00760,ko01100,map00760,map01100	M00115	R04292	RC01119	ko00000,ko00001,ko00002,ko01000	-	-	-	NadA
HKD2_k127_9937444_60	1090319.KE386571_gene1772	1.445e-42	164.0	COG2340@1|root,COG2340@2|Bacteria,1N02F@1224|Proteobacteria,2UENR@28211|Alphaproteobacteria,2K51M@204457|Sphingomonadales	204457|Sphingomonadales	S	SCP / Tpx-1 / Ag5 / PR-1 / Sc7 family of extracellular domains.	-	-	-	-	-	-	-	-	-	-	-	-	CAP
HKD2_k127_9937444_84	1549858.MC45_13515	2.755e-14	76.0	2AN25@1|root,31CZQ@2|Bacteria,1R3N2@1224|Proteobacteria,2U049@28211|Alphaproteobacteria,2K6MC@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9937444_71	1449076.JOOE01000003_gene3338	2.316e-26	117.0	COG0810@1|root,COG0810@2|Bacteria,1NB5F@1224|Proteobacteria,2USI1@28211|Alphaproteobacteria,2K2ZM@204457|Sphingomonadales	204457|Sphingomonadales	M	Gram-negative bacterial TonB protein C-terminal	-	-	-	ko:K03832	-	-	-	-	ko00000,ko02000	2.C.1.1	-	-	TonB_C
HKD2_k127_9937444_83	1090320.KB900605_gene1114	3.016e-15	79.0	COG3134@1|root,COG3134@2|Bacteria	2|Bacteria	I	Outer membrane lipoprotein	-	-	-	-	-	-	-	-	-	-	-	-	Rick_17kDa_Anti
HKD2_k127_9937444_57	1081640.AGFU01000082_gene3433	2.597e-44	165.0	2DMJE@1|root,32RYR@2|Bacteria,1N7PS@1224|Proteobacteria,2UFEW@28211|Alphaproteobacteria,2K57K@204457|Sphingomonadales	204457|Sphingomonadales	S	Domain of unknown function (DUF4112)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4112
HKD2_k127_9937444_26	1123267.JONN01000001_gene1578	2.132e-129	429.0	COG0747@1|root,COG0747@2|Bacteria,1MUZH@1224|Proteobacteria,2TWWQ@28211|Alphaproteobacteria,2KEK8@204457|Sphingomonadales	204457|Sphingomonadales	E	Bacterial extracellular solute-binding proteins, family 5 Middle	-	-	-	-	-	-	-	-	-	-	-	-	SBP_bac_5
HKD2_k127_9937444_4	1123267.JONN01000001_gene1579	3.15e-280	875.0	COG0744@1|root,COG0744@2|Bacteria,1QTST@1224|Proteobacteria,2TQQ8@28211|Alphaproteobacteria,2K0XK@204457|Sphingomonadales	204457|Sphingomonadales	M	Penicillin-binding Protein	-	-	2.4.1.129,3.4.16.4	ko:K05366	ko00550,ko01100,ko01501,map00550,map01100,map01501	-	-	-	ko00000,ko00001,ko01000,ko01003,ko01011	-	GT51	-	Transgly,Transpeptidase
HKD2_k127_9937444_82	1549858.MC45_02295	2.961e-15	77.0	COG3847@1|root,COG3847@2|Bacteria,1Q1G3@1224|Proteobacteria,2V11R@28211|Alphaproteobacteria,2K7TI@204457|Sphingomonadales	204457|Sphingomonadales	U	Flp pilus assembly protein, pilin Flp	-	-	-	ko:K02651	ko04112,map04112	-	-	-	ko00000,ko00001,ko02035,ko02044	-	-	-	Flp_Fap
HKD2_k127_9937444_36	1219035.NT2_07_00590	1.558e-90	314.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_9937444_28	1030157.AFMP01000042_gene1286	1.046e-124	418.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2U05U@28211|Alphaproteobacteria,2K1IQ@204457|Sphingomonadales	204457|Sphingomonadales	T	signal transduction protein containing a membrane domain, an EAL and a GGDEF domain	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_9937444_41	1123267.JONN01000001_gene1584	9.521e-77	263.0	COG0283@1|root,COG0283@2|Bacteria,1MUUD@1224|Proteobacteria,2U71H@28211|Alphaproteobacteria,2K3ZM@204457|Sphingomonadales	204457|Sphingomonadales	F	Belongs to the cytidylate kinase family. Type 1 subfamily	cmk	-	2.7.4.25	ko:K00945	ko00240,ko01100,map00240,map01100	M00052	R00158,R00512,R01665	RC00002	ko00000,ko00001,ko00002,ko01000	-	-	-	Cytidylate_kin
HKD2_k127_9937444_64	1123267.JONN01000001_gene1583	7.935e-38	146.0	COG4530@1|root,COG4530@2|Bacteria,1N42Z@1224|Proteobacteria,2UDI6@28211|Alphaproteobacteria,2K62H@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (FYDLN_acid)	-	-	-	-	-	-	-	-	-	-	-	-	FYDLN_acid
HKD2_k127_9937444_2	1123267.JONN01000001_gene463	1.412e-320	987.0	COG0539@1|root,COG0539@2|Bacteria,1MVAV@1224|Proteobacteria,2TQPV@28211|Alphaproteobacteria,2K0KT@204457|Sphingomonadales	204457|Sphingomonadales	J	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence	rpsA	-	-	ko:K02945	ko03010,map03010	M00178	-	-	br01610,ko00000,ko00001,ko00002,ko03011	-	-	-	S1
HKD2_k127_9937444_58	1123267.JONN01000001_gene464	1.011e-43	162.0	COG0776@1|root,COG0776@2|Bacteria,1MZ7M@1224|Proteobacteria,2UBR5@28211|Alphaproteobacteria,2K633@204457|Sphingomonadales	204457|Sphingomonadales	K	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control	ihfB	-	-	ko:K05788	-	-	-	-	ko00000,ko03032,ko03036,ko03400	-	-	-	Bac_DNA_binding
HKD2_k127_9937444_17	745310.G432_00860	7.411e-149	488.0	COG5001@1|root,COG5001@2|Bacteria,1MU2C@1224|Proteobacteria,2TQS3@28211|Alphaproteobacteria,2KCM1@204457|Sphingomonadales	204457|Sphingomonadales	T	Putative diguanylate phosphodiesterase	-	-	-	-	-	-	-	-	-	-	-	-	EAL,GGDEF
HKD2_k127_9937444_15	1030157.AFMP01000019_gene709	1.842e-165	531.0	COG0477@1|root,COG2814@2|Bacteria,1QTWR@1224|Proteobacteria,2TW1S@28211|Alphaproteobacteria,2K09D@204457|Sphingomonadales	204457|Sphingomonadales	EGP	Major facilitator superfamily	-	-	-	-	-	-	-	-	-	-	-	-	MFS_1
HKD2_k127_9937444_38	1123267.JONN01000001_gene1634	3.993e-87	291.0	COG0558@1|root,COG0558@2|Bacteria,1RCZ7@1224|Proteobacteria,2TUI7@28211|Alphaproteobacteria,2K47C@204457|Sphingomonadales	204457|Sphingomonadales	I	Belongs to the CDP-alcohol phosphatidyltransferase class-I family	pgsA	-	2.7.8.41,2.7.8.5	ko:K00995,ko:K08744	ko00564,ko01100,map00564,map01100	-	R01801,R02030	RC00002,RC00017,RC02795	ko00000,ko00001,ko01000	-	-	-	CDP-OH_P_transf
HKD2_k127_9937444_1	1123270.ATUR01000002_gene2401	0.0	1193.0	COG0376@1|root,COG0376@2|Bacteria,1MUBF@1224|Proteobacteria,2TQJ7@28211|Alphaproteobacteria,2K0B7@204457|Sphingomonadales	204457|Sphingomonadales	P	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity	katG	-	1.11.1.21	ko:K03782	ko00360,ko00380,ko00940,ko00983,ko01100,ko01110,map00360,map00380,map00940,map00983,map01100,map01110	-	R00602,R00698,R02596,R02670,R03919,R04007,R07443,R11906	RC00034,RC00213,RC00767,RC02141	ko00000,ko00001,ko01000	-	-	-	peroxidase
HKD2_k127_9937444_24	1030157.AFMP01000028_gene2285	2.963e-134	434.0	COG0583@1|root,COG0583@2|Bacteria,1MVA1@1224|Proteobacteria,2TSUS@28211|Alphaproteobacteria,2K012@204457|Sphingomonadales	204457|Sphingomonadales	K	Transcriptional regulator	-	-	-	ko:K04761	ko02026,map02026	-	-	-	ko00000,ko00001,ko03000	-	-	-	HTH_1,LysR_substrate
HKD2_k127_9937444_37	1470591.BW41_00610	1.766e-90	306.0	COG0730@1|root,COG0730@2|Bacteria,1RCVI@1224|Proteobacteria,2U5XM@28211|Alphaproteobacteria,2K04W@204457|Sphingomonadales	204457|Sphingomonadales	S	membrane transporter protein	-	-	-	ko:K07090	-	-	-	-	ko00000	-	-	-	TauE
HKD2_k127_9937444_34	1123267.JONN01000001_gene1469	5.475e-106	347.0	COG1045@1|root,COG1045@2|Bacteria,1MVFX@1224|Proteobacteria,2TQQ5@28211|Alphaproteobacteria,2K2GH@204457|Sphingomonadales	204457|Sphingomonadales	E	serine acetyltransferase	cysE	-	2.3.1.30	ko:K00640	ko00270,ko00920,ko01100,ko01110,ko01120,ko01200,ko01230,ko05111,map00270,map00920,map01100,map01110,map01120,map01200,map01230,map05111	M00021	R00586	RC00004,RC00041	ko00000,ko00001,ko00002,ko01000	-	-	-	Hexapep
HKD2_k127_9937444_55	1123267.JONN01000001_gene1468	1.652e-45	167.0	2CCMQ@1|root,32RW3@2|Bacteria,1MZHB@1224|Proteobacteria,2UCC9@28211|Alphaproteobacteria,2K53Z@204457|Sphingomonadales	204457|Sphingomonadales	S	Protein of unknown function (DUF2794)	-	-	-	-	-	-	-	-	-	-	-	-	DUF2794
HKD2_k127_9937444_20	1123267.JONN01000001_gene1467	2.756e-139	452.0	2BXMY@1|root,2Z8Y9@2|Bacteria,1Q2YR@1224|Proteobacteria,2U06T@28211|Alphaproteobacteria,2K32G@204457|Sphingomonadales	204457|Sphingomonadales	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9937444_46	1123267.JONN01000001_gene1463	7.782e-63	221.0	COG0742@1|root,COG0742@2|Bacteria,1MXKW@1224|Proteobacteria,2U70Y@28211|Alphaproteobacteria,2K3X3@204457|Sphingomonadales	204457|Sphingomonadales	L	Methyltransferase	-	-	2.1.1.171	ko:K08316	-	-	R07234	RC00003	ko00000,ko01000,ko03009	-	-	-	Cons_hypoth95
HKD2_k127_9937444_35	1335760.ASTG01000020_gene2594	6.328e-105	347.0	COG1187@1|root,COG1187@2|Bacteria,1MUCE@1224|Proteobacteria,2TQP2@28211|Alphaproteobacteria,2K0YS@204457|Sphingomonadales	204457|Sphingomonadales	J	Belongs to the pseudouridine synthase RsuA family	rluB	-	5.4.99.22	ko:K06178	-	-	-	-	ko00000,ko01000,ko03009	-	-	-	PseudoU_synth_2,S4
HKD2_k127_9937444_62	13689.BV96_01857	1.084e-38	149.0	COG0745@1|root,COG0745@2|Bacteria,1N2D5@1224|Proteobacteria,2UUU2@28211|Alphaproteobacteria,2K55K@204457|Sphingomonadales	204457|Sphingomonadales	T	response regulator	-	-	-	-	-	-	-	-	-	-	-	-	Response_reg
HKD2_k127_9937444_8	1112212.JH584235_gene3703	6.816e-220	695.0	COG4114@1|root,COG4114@2|Bacteria,1QZYT@1224|Proteobacteria,2TYSW@28211|Alphaproteobacteria,2KEN7@204457|Sphingomonadales	204457|Sphingomonadales	S	Acetyl-coenzyme A transporter 1	-	-	-	ko:K08218	ko01501,map01501	M00628	-	-	ko00000,ko00001,ko00002,ko02000	2.A.1.25	-	-	Acatn
HKD2_k127_9937444_22	1123267.JONN01000001_gene561	5.158e-136	447.0	COG0285@1|root,COG0285@2|Bacteria,1MVCH@1224|Proteobacteria,2TR64@28211|Alphaproteobacteria,2K1S3@204457|Sphingomonadales	204457|Sphingomonadales	H	Belongs to the folylpolyglutamate synthase family	folC	-	6.3.2.12,6.3.2.17	ko:K11754	ko00790,ko01100,map00790,map01100	M00126,M00841	R00942,R02237,R04241	RC00064,RC00090,RC00162	ko00000,ko00001,ko00002,ko01000	-	-	-	Mur_ligase_M
HKD2_k127_9937444_19	1123267.JONN01000001_gene562	1.313e-140	460.0	COG0777@1|root,COG0777@2|Bacteria,1MW8G@1224|Proteobacteria,2TRSH@28211|Alphaproteobacteria,2K159@204457|Sphingomonadales	204457|Sphingomonadales	I	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA	accD	-	2.1.3.15,6.4.1.2	ko:K01963	ko00061,ko00620,ko00640,ko00720,ko01100,ko01110,ko01120,ko01130,ko01200,ko01212,map00061,map00620,map00640,map00720,map01100,map01110,map01120,map01130,map01200,map01212	M00082,M00376	R00742,R04386	RC00040,RC00253,RC00367	ko00000,ko00001,ko00002,ko01000	-	-	-	Carboxyl_trans
HKD2_k127_9937444_40	1123267.JONN01000001_gene563	1.181e-84	287.0	COG0284@1|root,COG0284@2|Bacteria,1MW2C@1224|Proteobacteria,2TTB3@28211|Alphaproteobacteria,2K06D@204457|Sphingomonadales	204457|Sphingomonadales	F	Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP)	pyrF	-	4.1.1.23	ko:K01591	ko00240,ko01100,map00240,map01100	M00051	R00965	RC00409	ko00000,ko00001,ko00002,ko01000	-	-	-	OMPdecase
HKD2_k127_9937444_72	745310.G432_07010	5.211e-26	111.0	COG5416@1|root,COG5416@2|Bacteria,1NFVX@1224|Proteobacteria,2UHIC@28211|Alphaproteobacteria,2K759@204457|Sphingomonadales	204457|Sphingomonadales	S	Pfam:DUF1049	-	-	-	ko:K08992	-	-	-	-	ko00000	-	-	-	LapA_dom
HKD2_k127_9937444_14	1123267.JONN01000001_gene565	1.812e-171	547.0	COG1680@1|root,COG1680@2|Bacteria,1MY01@1224|Proteobacteria,2U2AI@28211|Alphaproteobacteria,2K0Z4@204457|Sphingomonadales	204457|Sphingomonadales	V	beta-lactamase	-	-	3.5.2.6	ko:K01467	ko01501,ko02020,map01501,map02020	M00628	R06363	RC01499	ko00000,ko00001,ko00002,ko01000	-	-	-	Beta-lactamase
HKD2_k127_9937444_49	366602.Caul_4302	2.593e-56	201.0	COG5592@1|root,COG5592@2|Bacteria,1RI8J@1224|Proteobacteria,2U7JS@28211|Alphaproteobacteria,2KH99@204458|Caulobacterales	204458|Caulobacterales	S	Hemerythrin HHE cation binding domain	-	-	-	-	-	-	-	-	-	-	-	-	Hemerythrin
HKD2_k127_9937444_32	1219035.NT2_07_00590	5.218e-113	379.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_9937444_53	1123267.JONN01000001_gene1740	1.493e-46	175.0	COG1376@1|root,COG1376@2|Bacteria,1Q823@1224|Proteobacteria,2TV64@28211|Alphaproteobacteria,2K2JH@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	-	-	-	-	-	-	-	-	-	SPOR,YkuD
HKD2_k127_9937444_45	29306.JOBE01000067_gene3691	6.121e-66	241.0	COG1814@1|root,COG1814@2|Bacteria,2GIZ3@201174|Actinobacteria	201174|Actinobacteria	S	membrane	-	-	-	-	-	-	-	-	-	-	-	-	VIT1
HKD2_k127_9937444_74	543728.Vapar_5465	3.755e-24	104.0	COG2388@1|root,COG2388@2|Bacteria,1N8AQ@1224|Proteobacteria,2VW02@28216|Betaproteobacteria	28216|Betaproteobacteria	S	acetyltransferase	-	-	-	ko:K06975	-	-	-	-	ko00000	-	-	-	Acetyltransf_CG
HKD2_k127_9937444_13	1144275.COCOR_05913	6.291e-172	556.0	COG0457@1|root,COG0457@2|Bacteria,1N0A9@1224|Proteobacteria,42YQ0@68525|delta/epsilon subdivisions,2WTRV@28221|Deltaproteobacteria,2YUFX@29|Myxococcales	28221|Deltaproteobacteria	S	COG0457 FOG TPR repeat	-	-	-	-	-	-	-	-	-	-	-	-	-
HKD2_k127_9937444_88	194867.ALBQ01000004_gene3602	0.000184	51.0	2AKT3@1|root,31BK4@2|Bacteria,1P4RX@1224|Proteobacteria,2UXC3@28211|Alphaproteobacteria,2K5G1@204457|Sphingomonadales	204457|Sphingomonadales	S	PilZ domain	-	-	-	-	-	-	-	-	-	-	-	-	PilZ
HKD2_k127_9937444_79	68199.JNZO01000028_gene7377	5.645e-20	100.0	29SM0@1|root,30DSB@2|Bacteria,2GN13@201174|Actinobacteria	201174|Actinobacteria	S	Protein of unknown function (DUF4239)	-	-	-	-	-	-	-	-	-	-	-	-	DUF4239
HKD2_k127_9937444_0	1123267.JONN01000001_gene570	0.0	1227.0	COG0210@1|root,COG0210@2|Bacteria,1MU0G@1224|Proteobacteria,2TS2B@28211|Alphaproteobacteria,2K04E@204457|Sphingomonadales	204457|Sphingomonadales	L	DNA helicase	uvrD	-	3.6.4.12	ko:K03657	ko03420,ko03430,map03420,map03430	-	-	-	ko00000,ko00001,ko01000,ko03400	-	-	-	UvrD-helicase,UvrD_C
HKD2_k127_9937444_80	1030157.AFMP01000013_gene3328	3.711e-19	92.0	COG3794@1|root,COG3794@2|Bacteria,1N2CZ@1224|Proteobacteria,2UEDD@28211|Alphaproteobacteria,2K66I@204457|Sphingomonadales	204457|Sphingomonadales	C	PFAM blue (type 1) copper domain protein	-	-	-	-	-	-	-	-	-	-	-	-	Cupredoxin_1
HKD2_k127_9937444_76	1123267.JONN01000001_gene2384	5.52e-23	104.0	2AM5D@1|root,31BZP@2|Bacteria,1Q7Y4@1224|Proteobacteria,2VE3K@28211|Alphaproteobacteria,2K6UE@204457|Sphingomonadales	204457|Sphingomonadales	S	Low affinity iron permease	-	-	-	-	-	-	-	-	-	-	-	-	Iron_permease
HKD2_k127_9937444_67	335659.S23_17570	3.343e-32	132.0	COG0071@1|root,COG0071@2|Bacteria,1N7C7@1224|Proteobacteria,2UFRX@28211|Alphaproteobacteria,3JYE3@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	O	Hsp20/alpha crystallin family	hspC2	-	-	ko:K13993	ko04141,map04141	-	-	-	ko00000,ko00001,ko03110	-	-	-	HSP20
HKD2_k127_9937444_61	1123269.NX02_09315	1.906e-42	168.0	COG0589@1|root,COG0589@2|Bacteria,1QD8E@1224|Proteobacteria,2TRQ7@28211|Alphaproteobacteria,2K4W9@204457|Sphingomonadales	204457|Sphingomonadales	T	Belongs to the universal stress protein A family	-	-	-	-	-	-	-	-	-	-	-	-	Usp
HKD2_k127_9937444_69	443598.AUFA01000004_gene5431	1.298e-28	122.0	COG3467@1|root,COG3467@2|Bacteria,1RAZD@1224|Proteobacteria,2TXIF@28211|Alphaproteobacteria,3K6W8@41294|Bradyrhizobiaceae	28211|Alphaproteobacteria	S	Pfam:Pyridox_oxidase	-	-	-	-	-	-	-	-	-	-	-	-	Putative_PNPOx
HKD2_k127_9937444_48	1123267.JONN01000001_gene873	2.696e-59	215.0	COG3637@1|root,COG3637@2|Bacteria,1N7U7@1224|Proteobacteria,2TXS0@28211|Alphaproteobacteria	28211|Alphaproteobacteria	M	Outer membrane protein beta-barrel domain	-	-	-	-	-	-	-	-	-	-	-	-	OMP_b-brl
HKD2_k127_9937444_21	1219035.NT2_07_00590	4.673e-137	448.0	COG2989@1|root,COG2989@2|Bacteria,1MV14@1224|Proteobacteria,2TRJ9@28211|Alphaproteobacteria,2K0KA@204457|Sphingomonadales	204457|Sphingomonadales	S	protein conserved in bacteria	-	-	-	ko:K21470	-	-	-	-	ko00000,ko01002,ko01011	-	-	-	PG_binding_1,YkuD
HKD2_k127_9937444_27	1123267.JONN01000001_gene611	1.741e-127	412.0	COG1028@1|root,COG1028@2|Bacteria,1MUBQ@1224|Proteobacteria,2TRPN@28211|Alphaproteobacteria,2K13W@204457|Sphingomonadales	204457|Sphingomonadales	IQ	Belongs to the short-chain dehydrogenases reductases (SDR) family	-	-	-	-	-	-	-	-	-	-	-	-	adh_short,adh_short_C2
HKD2_k127_9937444_42	1123267.JONN01000001_gene612	1.172e-74	261.0	COG1218@1|root,COG1218@2|Bacteria,1QY18@1224|Proteobacteria,2TXFA@28211|Alphaproteobacteria,2KEHZ@204457|Sphingomonadales	204457|Sphingomonadales	P	PFAM inositol monophosphatase	-	-	3.1.3.7	ko:K01082	ko00920,ko01100,ko01120,ko01130,map00920,map01100,map01120,map01130	-	R00188,R00508	RC00078	ko00000,ko00001,ko01000,ko03016	-	-	-	Inositol_P
## 2794 queries scanned
## Total time (seconds): 118.27787113189697
## Rate: 23.62 q/s